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Sample records for therapeutic equivalency

  1. Therapeutic equivalence study of two formulations (innovator v ...

    African Journals Online (AJOL)

    Therapeutic equivalence study of two formulations (innovator v. generic) of beclomethasone dipropionate in adult asthmatic patients. Haylene Nell, Charlene M. Louw, Helen Cyster, Zelda Williams, Philip G. Bardin, James R. Joubert ...

  2. Demonstration of Therapeutic Equivalence of Fluconazole Generic Products in the Neutropenic Mouse Model of Disseminated Candidiasis

    National Research Council Canada - National Science Library

    Gonzalez, Javier M; Rodriguez, Carlos A; Zuluaga, Andres F; Agudelo, Maria; Vesga, Omar

    2015-01-01

    .... We used the neutropenic mice model of disseminated candidiasis to challenge the therapeutic equivalence of three generic products of fluconazole compared with the innovator in terms of concentration...

  3. Determination of Therapeutic Equivalence of Generic Products of Gentamicin in the Neutropenic Mouse Thigh Infection Model

    Science.gov (United States)

    Zuluaga, Andres F.; Agudelo, Maria; Cardeño, John J.; Rodriguez, Carlos A.; Vesga, Omar

    2010-01-01

    Background Drug regulatory agencies (DRA) support prescription of generic products of intravenous antibiotics assuming therapeutic equivalence from pharmaceutical equivalence. Recent reports of deaths associated with generic heparin and metoprolol have raised concerns about the efficacy and safety of DRA-approved drugs. Methodology/Principal Findings To challenge the assumption that pharmaceutical equivalence predicts therapeutic equivalence, we determined in vitro and in vivo the efficacy of the innovator product and 20 pharmaceutically equivalent generics of gentamicin. The data showed that, while only 1 generic product failed in vitro (MIC = 45.3 vs. 0.7 mg/L, Pproducts (including gentamicin reference powder) failed in vivo against E. coli due to significantly inferior efficacy (Emax = 4.81 to 5.32 vs. 5.99 log10 CFU/g, P≤0.043). Although the design lacked power to detect differences in survival after thigh infection with P. aeruginosa, dissemination to vital organs was significantly higher in animals treated with generic gentamicin despite 4 days of maximally effective treatment. Conclusion Pharmaceutical equivalence does not predict therapeutic equivalence of generic gentamicin. Stricter criteria based on solid experimental evidence should be required before approval for human use. PMID:20505762

  4. Determination of therapeutic equivalence of generic products of gentamicin in the neutropenic mouse thigh infection model.

    Directory of Open Access Journals (Sweden)

    Andres F Zuluaga

    Full Text Available BACKGROUND: Drug regulatory agencies (DRA support prescription of generic products of intravenous antibiotics assuming therapeutic equivalence from pharmaceutical equivalence. Recent reports of deaths associated with generic heparin and metoprolol have raised concerns about the efficacy and safety of DRA-approved drugs. METHODOLOGY/PRINCIPAL FINDINGS: To challenge the assumption that pharmaceutical equivalence predicts therapeutic equivalence, we determined in vitro and in vivo the efficacy of the innovator product and 20 pharmaceutically equivalent generics of gentamicin. The data showed that, while only 1 generic product failed in vitro (MIC = 45.3 vs. 0.7 mg/L, P<0.05, 10 products (including gentamicin reference powder failed in vivo against E. coli due to significantly inferior efficacy (E(max = 4.81 to 5.32 vs. 5.99 log(10 CFU/g, Pequivalence does not predict therapeutic equivalence of generic gentamicin. Stricter criteria based on solid experimental evidence should be required before approval for human use.

  5. WHAT IS THERAPEUTIC EQUIVALENCE OF GENERIC DRUG AND HOW TO PROVE IT

    Directory of Open Access Journals (Sweden)

    N. P. Kutishenko

    2011-01-01

    Full Text Available The problem of generic drugs use in clinical practice and confirmation of their therapeutic equivalence is discussed. The significance of studies on generic drugs bioequivalence, as well as details of international practice and regulations in this area is explained.

  6. Generics and cost-effective prescribing in Belgium: does bioequivalence always translate in therapeutic equivalence?

    Science.gov (United States)

    Dupont, A G; Heller, F

    2009-01-01

    As many other countries, Belgium has a policy to promote the use of generic pharmaceutical products. In order to protect consumers, these generic products must be demonstrated to be essentially similar to the previously approved product, typically an innovator product. The therapeutic equivalence of a generic and an innovator product is most commonly based on the demonstration of bioequivalence, i.e. clinically insignificant differences in the rate and extent of drug absorption usually assessed from pharmacokinetic measurements, in a normal and healthy population. This article reviews the bioequivalence requirements for generic products and examines whether bioequivalence always adequately substantiates therapeutic equivalence and interchangeability. Clinical practice has identified a number of drug classes for which generic substitution should be approached with caution. Current bioequivalence requirements are based on a measure of average bioequivalence. There are fears that use of this measure may be inappropriate in the case of a drug with a narrow therapeutic range or high intrasubject or intersubject variability. Under these circumstances, measures of individual and population bioequivalence are proposed to be more accurate than measures of average bioequivalence. Bioequivalence issues are discussed together more general concerns about generic drug substitution, such as differences in product and packaging appearance and differences in excipients.

  7. VALUE OF THERAPEUTIC EQUIVALENCE IN SUBSTITUTION OF ORIGINAL DRUG WITH GENERIC BY EXAMPLE OF FOSINIPRIL

    Directory of Open Access Journals (Sweden)

    N. P. Kutishenko

    2011-01-01

    Full Text Available Aim. To study the therapeutic equivalence of original and generic fosinopril in patients with arterial hypertension (HT of 1-2 degrees, and to evaluate the cost effectiveness of original drug substitution with generic. Material and methods. Patients (n=36 with HT of 1-2 degree aged 41-82 years and disease duration up 3 to 22 years included in an open, crossover , randomized trial. All patients had two courses of treatment: with generic (Fosicard and the original drug (Monopril; sequence of courses was determined by randomization. Wash-out period (10-14 days preceded each course. Treatment duration was 6 weeks; drugs were administered QD; initial dose - 10 mg/day. Blood pressure (BP and heart rate (HR were evaluated at the end of the wash-out period, and in 2, 4 and 6 weeks of therapy. In case of ineffective BP control (>140/90 mm Hg hydrochlorothiazide 12.5 mg was added initially and dose fosinopril was increased up to 20 mg/day next. Results. Patients in groups were comparable by basic clinical parameters. Both fosinopril based drugs have comparable antihypertensive effect. Differences between their effect on systolic and diastolic BP as well as HR at all steps of treatment were not significant. The individual analysis revealed a tendency to more pronounced Monopril antihypertensive effect compared with Fosicard, but the differences were not significant. An average dose of Monopril was 11.8±3.9 mg/day , and Fosicard — 13.2±4.7 mg/day (p=0.13; the rate of monotherapy with both drugs of fosinopril at dose of 10 mg/day was similar (in 41% and 44% of patients, respectively; the rate of combined therapies with various composition differed insignificantly. Reduction in BP <140/90 mmHg was recorded at the end of the study in 29 (85.3% patients treated with Monorpil and in 27 (79.4% — Fosicard (p=0.52. Both drugs showed a good safety profile. Conclusion. Fosicard or its combination with hydrochlorothiazide is therapeutically equivalent to

  8. Is the time in therapeutic range using the ratio of tests equivalent to the Rosendaal method?

    Science.gov (United States)

    Caldeira, Daniel; Cruz, Inês; Morgado, Gonçalo; Stuart, Bruno; Gomes, Ana Catarina; Martins, Cristina; João, Isabel; Pereira, Hélder

    2015-12-01

    The percentage of time in therapeutic range (TTR) is a measure of anticoagulation quality with vitamin K antagonists (VKAs). The method most commonly used in clinical trials is the Rosendaal TTR. However, the application of this method in daily practice for clinical decision lacks appropriate instruments. We aimed to evaluate the percentage of tests within the target international normalized ratio (INR) (tests ratio) as a surrogate of Rosendaal TTR. We performed an observational and retrospective study to evaluate the TTR according to the Rosendaal method and tests ratio. We included all outpatients who attended the cardiology anticoagulation clinic of a Portuguese hospital (2011-2013), whose target INR was 2.0-3.0. Three hundred and seventy-seven VKA-treated patients followed for a mean 1.3 years were evaluated. Rosendaal methold and tests ratio significantly correlated (Rho Spearman 0.88, P < 0.001), but the Bland-Altman plot evaluation showed a clinically relevant data dispersion [95% confidence interval (95% CI) -12.9 to 23.1] around a mean difference in TTR -5.1% using the tests ratio method. The linear regression Passing-Bablok confirmed the existence of significant data dispersion and systematic differences. The tests ratio less than 60% had a sensitivity of 91.6%, specificity of 72.3%, positive predictive value (PPV) of 72.2% and negative predictive value (NPV) of 91.6%, for the diagnosis of patients inadequately anticoagulated (Rosendaal TTR <60%). Tests ratio had a c-statistics of 0.94 (95% CI 0.91-0.96). Number of tests in 6 months had a c-statistics of 0.70 (95% CI 0.65-0.75). Tests ratio underestimated TTR in 5% and was not considered equivalent to Rosendaal TTR due to the high variability between methods. Nevertheless, the use of tests ratio less than 60% may be a reasonable option to detect inadequate anticoagulation, as it is a sensitive method and excluded most of the patients with adequate control.

  9. Clinical case reports raise doubts about the therapeutic equivalence of an iron sucrose similar preparation compared with iron sucrose originator.

    Science.gov (United States)

    Stein, Jürgen; Dignass, Axel; Chow, Kai Uwe

    2012-02-01

    Intravenous iron sucrose has been used to treat iron deficiency and iron deficiency anaemia associated with different chronic diseases for several decades. Despite the complex structure of iron sucrose, copies called iron sucrose similars (ISSs) have been approved according to the generic approach and therefore, therapeutic equivalence is taken for granted. In February 2011, three patients who previously tolerated well the prescribed iron sucrose originator experienced urticaria, oedema and headache within 1 hour after infusion of an ISS that had been substituted for the originator at the pharmacy level. One patient collapsed due to severe hypovolaemic dysregulation and required hospitalisation. Due to emerging evidence that ISSs differ from the iron sucrose originator in safety and efficacy profiles, it seems prudent for physicians as well as patients who require intravenous (i.v.) iron to have available data on therapeutic equivalence of new ISS preparations versus the originator. This may be especially important in patients who are chronically ill and need iron supplementation on a regular, long-term basis.

  10. Relevance of various animal models of human infections to establish therapeutic equivalence of a generic product of piperacillin/tazobactam.

    Science.gov (United States)

    Agudelo, Maria; Rodriguez, Carlos A; Zuluaga, Andres F; Vesga, Omar

    2015-02-01

    After demonstrating with diverse intravenous antibacterials that pharmaceutical equivalence (PE) does not predict therapeutic equivalence, we tested a single generic product of piperacillin/tazobactam (TZP) in terms of PE, pharmacokinetics and in vitro/vivo pharmacodynamics against several pathogens in neutropenic mouse thigh, lung and brain infection models. A generic product was compared head-to-head against the innovator. PE was evaluated by microbiological assay. Single-dose serum pharmacokinetics were determined in infected mice, and the MIC/MBC were determined by broth microdilution. In vivo experiments were done in a blind fashion. Reproducibility was tested on different days using different infecting organisms and animal models. Neutropenic MPF mice were infected in the thighs with Staphylococcus aureus GRP-0057 or Pseudomonas aeruginosa PA01 and in the lungs or brain with Klebsiella pneumoniae ATCC 10031. Treatment started 2h (thigh and brain) or 14 h (lung) after infection and was administered every 3h over 24h (thigh and lung) or 48 h (brain). Both products exhibited the same MIC/MBC against each strain, yielded overlaid curves in the microbiological assay (P>0.21) and were bioequivalent (IC90 83-117% for AUC test/reference ratio). In vivo, the generic product and innovator were again undistinguishable in all models and against the different bacterial pathogens involved. The relevance of these neutropenic murine models of infection was established by demonstrating their accuracy to predict the biological response following simultaneous treatment with a generic product or the innovator of TZP. Therapeutic equivalence of the generic product was proved in every model and against different pathogens. Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

  11. THERAPEUTIC EQUIVALENCE OF ORIGINAL CLOPIDOGREL (PLAVIX AND ITS GENERIC (EGITROMB. RESULTS OF COMPARATIVE RANDOMIZED CROSS-OVER BLIND STUDY

    Directory of Open Access Journals (Sweden)

    V. V. Yakusevich

    2011-01-01

    Full Text Available Aim. To study therapeutic equivalence (efficacy, safety and tolerability of original clopidogrel (Plavix and its generic (Egitromb in patients of high cardiovascular risk. Material and methods. Thirty one patients with coronary heart disease and indications for clopidogrel therapy were involved into the randomized cross-over blind study. Half of the patients received original clopidogrel (75 mg daily during the first 2 weeks and then they received generic clopidogrel in the same dose during next 2 weeks. Another half of the patients received the drugs in reverse order. Antiplatelet activity of Plavix and Egitromb was estimated by effects on ADP-induced platelet aggregation initially and after 2 weeks of treatment with each drug. Study blinding was provided by the following approach: doctors of cardiology clinic performed clinical monitoring and drug distribution; coded blood samples for platelet aggregation assessment were studied in independent laboratory of thrombosis; statistical data analysis was performed by biostatistics expert in other research center. Results. 2-week therapy with each drug led to a significant decrease of ADP-induced platelet aggregation which remained low after switching from original drug to generic and vice versa. Aggregation dynamics did not depend on the first administered drug. There were no significant differences between aggregation changes as a result of treatment with original or generic drug. No one adverse event was observed in association with both drugs therapy. Conclusion. Generic drug Egitromb (Egis, Hungary and original clopidogrel Plavix (Sanofi-Aventis, France have equivalent antiplatelet effect.

  12. Therapeutic equivalence requires pharmaceutical, pharmacokinetic, and pharmacodynamic identities: true bioequivalence of a generic product of intravenous metronidazole.

    Science.gov (United States)

    Agudelo, M; Vesga, O

    2012-05-01

    allow a thorough demonstration of the therapeutic equivalence of generic antimicrobials.

  13. Three different chromogenic methods do not give equivalent anti-Xa levels for patients on therapeutic low molecular weight heparin (dalteparin) or unfractionated heparin.

    Science.gov (United States)

    Kovacs, M J; Keeney, M; MacKinnon, K; Boyle, E

    1999-02-01

    In this study we compare three chromogenic methods (IL-Heparin, Stachrom Heparin and Heparin Sigma) on two different instruments (ACL300+ and AMAX CS190) for patients on dalteparin (n = 41), a low molecular weight heparin or unfractionated heparin (n = 50). For dalteparin the mean anti-Xa levels for IL-Heparin, Stachrom Heparin and Heparin Sigma were 0.27, 0.30 and 0.21 U/ml, respectively, while for heparin they were 0.52, 0.55 and 0.41 U/ml, respectively. To test for instrument specific effects, IL-Heparin and Stachrom Heparin were repeated on both instruments on 42 patients receiving unfractionated heparin. For IL-Heparin the mean anti-Xa levels on the AMAX CS190 and ACL300+ were 0.51 and 0.59 U/ml, respectively, while for Stachrom Heparin they were 0.55 and 0.67 anti-Xa U/ml. We conclude that different chromogenic anti-Xa methods do not give equivalent anti-Xa levels for the same samples. Moreover, the differences are clinically significant. This is not explained entirely by instrumentation effects. Recommended therapeutic ranges may need to be method and instrument specific.

  14. Equivalent brain SPECT perfusion changes underlying therapeutic efficiency in pharmacoresistant depression using either high-frequency left or low-frequency right prefrontal rTMS.

    Science.gov (United States)

    Richieri, Raphaëlle; Boyer, Laurent; Padovani, Romain; Adida, Marc; Colavolpe, Cécile; Mundler, Olivier; Lançon, Christophe; Guedj, Eric

    2012-12-03

    Functional neuroimaging studies have suggested similar mechanisms underlying antidepressant effects of distinct therapeutics. This study aimed to determine and compare functional brain patterns underlying the antidepressant response of 2 distinct protocols of repetitive transcranial magnetic stimulation (rTMS). 99mTc-ECD SPECT was performed before and after rTMS of dorsolateral prefrontal cortex in 61 drug-resistant right-handed patients with major depression, using high frequency (10Hz) left-side stimulation in 33 patients, and low frequency (1Hz) right-side stimulation in 28 patients. Efficiency of rTMS response was defined as at least 50% reduction of the baseline Beck Depression Inventory score. We compared the whole-brain voxel-based brain SPECT changes in perfusion after rTMS, between responders and non-responders in the whole sample (pleft- and right-stimulation. Before rTMS, the left- and right-prefrontal stimulation groups did not differ from clinical data and brain SPECT perfusion. rTMS efficiency (evaluated on % of responders) was statistically equivalent in the two groups of patients. In the whole-group of responder patients, a perfusion decrease was found after rTMS, in comparison to non-responders, within the left perirhinal cortex (BA35, BA36). This result was secondarily confirmed separately in the two subgroups, i.e. after either left stimulation (p=0.017) or right stimulation (pbrain functional changes associated to antidepressive efficiency, consisting to a remote brain limbic activity decrease within the left perirhinal cortex. However, these results will have to be confirmed in a double-blind randomized trial using a sham control group. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Critical quality attributes, in vitro release and correlated in vitro skin permeation-in vivo tape stripping collective data for demonstrating therapeutic (non)equivalence of topical semisolids: A case study of "ready-to-use" vehicles.

    Science.gov (United States)

    Ilić, Tanja; Pantelić, Ivana; Lunter, Dominique; Đorđević, Sanela; Marković, Bojan; Ranković, Dragana; Daniels, Rolf; Savić, Snežana

    2017-08-07

    This work aimed to prove the ability of "ready-to-use" topical vehicles based on alkyl polyglucoside-mixed emulsifier (with/without co-solvent modifications) to replace the conventionally used pharmacopoeial bases (e.g., non-ionic hydrophilic cream) in compounding practice. For this purpose, considering the regulatory efforts to establish alternative, scientifically valid methods for evaluating therapeutic equivalence of topical semisolids, we performed a comparative assessment of microstructure, selected critical quality attributes (CQAs) and in vitro/in vivo product performances, by utilizing aceclofenac as a model drug. The differences in composition between investigated samples have imposed remarkable variances in monitored CQAs (particularly in the amount of aceclofenac dissolved, rheological properties and water distribution mode), reflecting the distinct differences in microstructure formed, as partially observed by polarization microscopy and confocal Raman spectral imaging. Although not fully indicative of the in vivo performances, in vitro release data (vertical diffusion vs. immersion cells) proved the microstructure peculiarities, asserting the rheological properties as decisive factor for obtained liberation profiles. Contrary, in vitro permeation results obtained using pig ear epidermis correlated well with in vivo dermatopharmacokinetic data and distinguished unequivocally between tested formulations, emphasizing the importance of skin/vehicle interactions. In summary, suggested multi-faceted approach can provide adequate proof on topical semisolids therapeutic equivalence or lack thereof. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Therapeutic equivalence of diclofenac sustained-released 75 mg tablets and diclofenac enteric-coated 50 mg tablets in the treatment of painful osteoarthritis.

    Science.gov (United States)

    Le Loët, X; Dreiser, R L; Le Gros, V; Febvre, N

    1997-09-01

    Efficacy and tolerability of diclofenac sustained-released (SR) 75 mg tablets taken b.i.d. were compared with that of enteric-coated diclofenac sodium 50 mg tablets given t.i.d. in a seven-day, randomised, double-blind, double-dummy, parallel groups study in 294 outpatients suffering from painful femorotibial or hip osteoarthritis. Primary efficacy criteria were spontaneous joint pain assessed on serial visual analogue scales during the first 36 hours and after 48 hours of treatment. The two treatments had equivalent efficacy since all the 90% confidence intervals of differences between means for pain intensity between the two groups were included within the interval (-10 mm; +10 mm). Rates of overall efficacy judged good to excellent ranged from 74.3-78.5% in both groups. One or more drug-related adverse events, mainly gastrointestinal, was reported by 24.5% and 27.2% of patients in diclofenac SR 75 mg and diclofenac 50 mg groups, respectively. Percentage of good compliance (i.e. > 90%) was higher with diclofenac SR 75 mg (p < 0.001).

  17. Politico-economic equivalence

    DEFF Research Database (Denmark)

    Gonzalez Eiras, Martin; Niepelt, Dirk

    2015-01-01

    and a state are equivalent to another such pair if both pairs give rise to the same allocation in politico-economic equilibrium. The equivalence conditions help to identify factors that render institutional change non-neutral and to construct politico-economic equilibria in new policy regimes. We exemplify......Traditional "economic equivalence'' results, like the Ricardian equivalence proposition, define equivalence classes over exogenous policies. We derive "politico-economic equivalence" conditions that apply in environments where policy is endogenous and chosen sequentially. A policy regime...

  18. Comparison of the effectiveness of a milk-free soy-maize-sorghum-based ready-to-use therapeutic food to standard ready-to-use therapeutic food with 25% milk in nutrition management of severely acutely malnourished Zambian children: an equivalence non-blinded cluster randomised controlled trial.

    Science.gov (United States)

    Irena, Abel H; Bahwere, Paluku; Owino, Victor O; Diop, ElHadji I; Bachmann, Max O; Mbwili-Muleya, Clara; Dibari, Filippo; Sadler, Kate; Collins, Steve

    2015-12-01

    Community-based Management of Acute Malnutrition using ready-to-use therapeutic food (RUTF) has revolutionised the treatment of severe acute malnutrition (SAM). However, 25% milk content in standard peanut-based RUTF (P-RUTF) makes it too expensive. The effectiveness of milk-free RUTF has not been reported hitherto. This non-blinded, parallel group, cluster randomised, controlled, equivalence trial that compares the effectiveness of a milk-free soy-maize-sorghum-based RUTF (SMS-RUTF) with P-RUTF in treatment of children with SAM, closes the gap. A statistician randomly assigned health centres (HC) either to the SMS-RUTF (n = 12; 824 enrolled) or P-RUTF (n = 12; 1103 enrolled) arms. All SAM children admitted at the participating HCs were enrolled. All the outcomes were measured at individual level. Recovery rate was the primary outcome. The recovery rates for SMS-RUTF and P-RUTF were 53.3% and 60.8% for the intention-to-treat (ITT) analysis and 77.9% and 81.8% for per protocol (PP) analyses, respectively. The corresponding adjusted risk difference (ARD) and 95% confidence interval, were -7.6% (-14.9, 0.6%) and -3.5% (-9,6., 2.7%) for ITT (P = 0.034) and PP analyses (P = 0.257), respectively. An unanticipated interaction (interaction P < 0.001 for ITT analyses and 0.0683 for PP analyses) between the study arm and age group was observed. The ARDs were -10.0 (-17.7 to -2.3)% for ITT (P = 0.013) and -4.7 (-10.0 to 0.7) for PP (P = 0.083) analyses for the <24 months age group and 2.1 (-10.3,14.6)% for ITT (P = 0.726) and -0.6 (-16.1, 14.5) for PP (P = 0.939) for the ≥24 months age group. In conclusion, the study did not confirm our hypothesis of equivalence between SMS-RUTF and P-RUTF in SAM management. © 2013 John Wiley & Sons Ltd.

  19. Chemical equivalence assessment of three brands of ...

    African Journals Online (AJOL)

    Assay for content of active ingredients is a critical test of drug quality; failure to meet up the standard for content of active ingredients will result to sub therapeutic quantities. Three brands (A, B and C) of carbamazepine were assayed to determine their chemical equivalence as well as their anticonvulsant activities. This was ...

  20. Design and rationale for the WARFA trial: a randomized controlled cross-over trial testing the therapeutic equivalence of branded and generic warfarin in atrial fibrillation patients in Brazil.

    Science.gov (United States)

    Freitas, Carolina Gomes; Walsh, Michael; Atallah, Álvaro Nagib

    2017-06-07

    Warfarin is a commonly used anticoagulant. Whether a given dose of the different formulations of Brazilian warfarin will result in the same effect on the international normalized ratio (INR) is uncertain. The aim of the WARFA trial is to determine whether the branded and two generic warfarins available in Brazil differ in their effect on the INR. WARFA is a cross-over RCT comparing three warfarins. The formulations tested are the branded Marevan® (Uniao Quimica/Farmoquimica) and two generic warfarin (manufactured respectively by Uniao Quimica Farmaceutica Nacional and Laboratorio Teuto Brasileiro). All of them were manufactured in Brazil, are available in all settings of the Brazilian healthcare system and were purchased from retail drugstores. Eligible participants had atrial fibrillation or flutter, had been using warfarin for at least 2 months with a therapeutic range of 2.0-3.0 and had low variability in INR results during the 1st period of the trial. Our primary outcome, for which we have an equality hypothesis, is the difference between warfarins in the mean absolute difference between two INR results, obtained after three and 4 weeks with each drug. Our secondary outcomes, that will be tested for inequality (except for the mean INR, which will be tested for equality), include the difference in the warfarin dose, and time in therapeutic range. Clinical events and adherence were also recorded and will be reported. To our knowledge, WARFA will be the first comparison of the more readily applicable INR results between branded and generic warfarins in Brazil. WARFA is important because warfarins are commonly switched between in the course of a chronic treatment in Brazil. Final results of WARFA are expected in May 2017. ClinicalTrials.gov NCT02017197 . Registered 11 December 2013.

  1. Generic Vancomycin Products Fail In Vivo despite Being Pharmaceutical Equivalents of the Innovator ▿

    OpenAIRE

    Vesga, Omar; Agudelo, Maria; Beatriz E. Salazar; Rodriguez, Carlos A.; Zuluaga, Andres F

    2010-01-01

    Generic versions of intravenous antibiotics are not required to demonstrate therapeutic equivalence with the innovator because therapeutic equivalence is assumed from pharmaceutical equivalence. To test such assumptions, we studied three generic versions of vancomycin in simultaneous experiments with the innovator and determined the concentration and potency of the active pharmaceutical ingredient by microbiological assay, single-dose pharmacokinetics in infected mice, antibacterial effect by...

  2. Approved Drug Products with Therapuetic Equivalence Evaluations (Orange Book)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The publication Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book) identifies drug products approved on...

  3. System equivalent model mixing

    NARCIS (Netherlands)

    Klaassen, Steven W.B.; van der Seijs, M.V.; de Klerk, D.

    2017-01-01

    This paper introduces SEMM: a method based on Frequency Based Substructuring (FBS) techniques that enables the construction of hybrid dynamic models. With System Equivalent Model Mixing (SEMM) frequency based models, either of numerical or experimental nature, can be mixed to form a hybrid model.

  4. Equivalent Quantum Circuits

    OpenAIRE

    Garcia-Escartin, Juan Carlos; Chamorro-Posada, Pedro

    2011-01-01

    Quantum algorithms and protocols are often presented as quantum circuits for a better understanding. We give a list of equivalence rules which can help in the analysis and design of quantum circuits. As example applications we study quantum teleportation and dense coding protocols in terms of a simple XOR swapping circuit and give an intuitive picture of a basic gate teleportation circuit.

  5. Establishing Substantial Equivalence: Metabolomics

    Science.gov (United States)

    Beale, Michael H.; Ward, Jane L.; Baker, John M.

    Modern ‘metabolomic’ methods allow us to compare levels of many structurally diverse compounds in an automated fashion across a large number of samples. This technology is ideally suited to screening of populations of plants, including trials where the aim is the determination of unintended effects introduced by GM. A number of metabolomic methods have been devised for the determination of substantial equivalence. We have developed a methodology, using [1H]-NMR fingerprinting, for metabolomic screening of plants and have applied it to the study of substantial equivalence of field-grown GM wheat. We describe here the principles and detail of that protocol as applied to the analysis of flour generated from field plots of wheat. Particular emphasis is given to the downstream data processing and comparison of spectra by multivariate analysis, from which conclusions regarding metabolome changes due to the GM can be assessed against the background of natural variation due to environment.

  6. From equivalence to adaptation

    Directory of Open Access Journals (Sweden)

    Paulina Borowczyk

    2009-01-01

    Full Text Available The aim of this paper is to illustrate in which cases the translators use the adaptation when they are confronted with a term related to sociocultural aspects. We will discuss the notions of equivalence and adaptation and their limits in the translation. Some samples from Arte TV news and from the American film Shrek translated into Polish, German and French will be provided as a support for this article.

  7. Comments on TNT Equivalence

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, P.W.

    1994-07-01

    The term ``TNT Equivalence`` is used throughout the explosives and related industries to compare the effects of the output of a given explosive to that of TNT. This is done for technical design reasons in scaling calculation such as for the prediction of blast waves, craters, and structural response, and is also used as a basis for government regulations controlling the shipping, handling and storage of explosive materials, as well as for the siting and design of explosive facilities. TNT equivalence is determined experimentally by several different types of tests, the most common of which include: plate dent, ballistic mortar, trauzl, sand crush, and air blast. All of these tests do not necessarily measure the same output property of the sample explosive. As examples of this, some tests depend simply upon the CJ pressure, some depend upon the PV work in the CJ zone and in the Taylor wave behind the CJ plane, some are functions of the total work which includes that from secondary combustion in the air mixing region of the fireball and are acutely effected by the shape of the pressure-time profile of the wave. Some of the tests incorporate systematic errors which are not readily apparent, and which have a profound effect upon skewing the resultant data. Further, some of the tests produce different TNT Equivalents for the same explosive which are a function of the conditions at which the test is run. This paper describes the various tests used, discusses the results of each test and makes detailed commentary on what the test is actually measuring, how the results may be interpreted, and if and how these results can be predicted by first principals based calculations. Extensive data bases are referred to throughout the paper and used in examples for each point in the commentaries.

  8. Equivalence, commensurability, value

    DEFF Research Database (Denmark)

    Albertsen, Niels

    2017-01-01

    Deriving value in Capital Marx uses three commensurability arguments (CA1-3). CA1 establishes equivalence in exchange as exchangeability with the same third commodity. CA2 establishes value as common denominator in commodities: embodied abstract labour. CA3 establishes value substance...... as commonality of labour: physiological labour. Tensions between these logics have permeated Marxist interpretations of value. Some have supported value as embodied labour (CA2, 3), others a monetary theory of value and value as ‘pure’ societal abstraction (ultimately CA1). They all are grounded in Marx....

  9. Establishing Substantial Equivalence: Proteomics

    Science.gov (United States)

    Lovegrove, Alison; Salt, Louise; Shewry, Peter R.

    Wheat is a major crop in world agriculture and is consumed after processing into a range of food products. It is therefore of great importance to determine the consequences (intended and unintended) of transgenesis in wheat and whether genetically modified lines are substantially equivalent to those produced by conventional plant breeding. Proteomic analysis is one of several approaches which can be used to address these questions. Two-dimensional PAGE (2D PAGE) remains the most widely available method for proteomic analysis, but is notoriously difficult to reproduce between laboratories. We therefore describe methods which have been developed as standard operating procedures in our laboratory to ensure the reproducibility of proteomic analyses of wheat using 2D PAGE analysis of grain proteins.

  10. Biomonitoring Equivalents for selenium.

    Science.gov (United States)

    Hays, Sean M; Macey, Kristin; Nong, Andy; Aylward, Lesa L

    2014-10-01

    Selenium is an essential nutrient for human health with a narrow range between essentiality and toxicity. Selenium is incorporated into several proteins that perform important functions in the body. With insufficient selenium intake, the most notable effect is Keshan disease, an endemic cardiomyopathy in children. Conversely, excessive selenium intake can result in selenosis, manifested as brittle nails and hair and gastro-intestinal disorders. As such, guidance values have been established to protect against both insufficient and excessive selenium exposures. Dietary Reference Intakes (DRIs) have been established as standard reference values for nutritional adequacy in North America. To protect against selenosis resulting from exposure to excessive amounts of selenium, several government and non-governmental agencies have established a range of guidance values. Exposure to selenium is primarily through the diet, but monitoring selenium intake is difficult. Biomonitoring is a useful means of assessing and monitoring selenium status for both insufficient and excessive exposures. However, to be able to interpret selenium biomonitoring data, levels associated with both DRIs and toxicity guidance values are required. Biomonitoring Equivalents (BEs) were developed for selenium in whole blood, plasma and urine. The BEs associated with assuring adequate selenium intake (Estimated Average Requirements - EAR) are 100, 80 and 10μg/L in whole blood, plasma and urine, respectively. The BEs associated with protection against selenosis range from 400 to 480μg/L in whole blood, 180-230μg/L in plasma, and 90-110μg/L in urine. These BE values can be used by both regulatory agencies and public health officials to interpret selenium biomonitoring data in a health risk context. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. Equivalence principle and gravitational redshift.

    Science.gov (United States)

    Hohensee, Michael A; Chu, Steven; Peters, Achim; Müller, Holger

    2011-04-15

    We investigate leading order deviations from general relativity that violate the Einstein equivalence principle in the gravitational standard model extension. We show that redshift experiments based on matter waves and clock comparisons are equivalent to one another. Consideration of torsion balance tests, along with matter-wave, microwave, optical, and Mössbauer clock tests, yields comprehensive limits on spin-independent Einstein equivalence principle-violating standard model extension terms at the 10(-6) level.

  12. Testing statistical hypotheses of equivalence

    CERN Document Server

    Wellek, Stefan

    2010-01-01

    Equivalence testing has grown significantly in importance over the last two decades, especially as its relevance to a variety of applications has become understood. Yet published work on the general methodology remains scattered in specialists' journals, and for the most part, it focuses on the relatively narrow topic of bioequivalence assessment.With a far broader perspective, Testing Statistical Hypotheses of Equivalence provides the first comprehensive treatment of statistical equivalence testing. The author addresses a spectrum of specific, two-sided equivalence testing problems, from the

  13. Estimating equivalence with quantile regression

    Science.gov (United States)

    Cade, B.S.

    2011-01-01

    Equivalence testing and corresponding confidence interval estimates are used to provide more enlightened statistical statements about parameter estimates by relating them to intervals of effect sizes deemed to be of scientific or practical importance rather than just to an effect size of zero. Equivalence tests and confidence interval estimates are based on a null hypothesis that a parameter estimate is either outside (inequivalence hypothesis) or inside (equivalence hypothesis) an equivalence region, depending on the question of interest and assignment of risk. The former approach, often referred to as bioequivalence testing, is often used in regulatory settings because it reverses the burden of proof compared to a standard test of significance, following a precautionary principle for environmental protection. Unfortunately, many applications of equivalence testing focus on establishing average equivalence by estimating differences in means of distributions that do not have homogeneous variances. I discuss how to compare equivalence across quantiles of distributions using confidence intervals on quantile regression estimates that detect differences in heterogeneous distributions missed by focusing on means. I used one-tailed confidence intervals based on inequivalence hypotheses in a two-group treatment-control design for estimating bioequivalence of arsenic concentrations in soils at an old ammunition testing site and bioequivalence of vegetation biomass at a reclaimed mining site. Two-tailed confidence intervals based both on inequivalence and equivalence hypotheses were used to examine quantile equivalence for negligible trends over time for a continuous exponential model of amphibian abundance. ?? 2011 by the Ecological Society of America.

  14. Full Static Output Feedback Equivalence

    Directory of Open Access Journals (Sweden)

    Aristotle G. Yannakoudakis

    2013-01-01

    Full Text Available We present a constructive solution to the problem of full output feedback equivalence, of linear, minimal, time-invariant systems. The equivalence relation on the set of systems is transformed to another on the set of invertible block Bezout/Hankel matrices using the isotropy subgroups of the full state feedback group and the full output injection group. The transformation achieving equivalence is calculated solving linear systems of equations. We give a polynomial version of the results proving that two systems are full output feedback equivalent, if and only if they have the same family of generalized Bezoutians. We present a new set of output feedback invariant polynomials that generalize the breakaway polynomial of scalar systems.

  15. The paradox of energy equivalence

    OpenAIRE

    Isaac, Nick J. B.; Storch, David; Carbone, Chris

    2013-01-01

    Energy equivalence, the notion that population energy flux is independent of body mass, has become a key concept in ecology. We argue that energy equivalence is not an ecological ‘rule’, as claimed, but a flawed concept beset by circular reasoning. In fact, the independence of mass and energy flux is a null hypothesis. We show that our mechanistic understanding of size–density relationships (SDRs) follows directly from this null model and the assumption that energy limits abundance. Paradoxic...

  16. Matching of equivalent field regions

    DEFF Research Database (Denmark)

    Appel-Hansen, Jørgen; Rengarajan, S.B.

    2005-01-01

    screen, having the same homogeneous medium on both sides and an impressed current on one aide, an alternative procedure is relevant. We make use of the fact that in the aperture the tangential component of the magnetic field due to the induced currents in the screen is zero. The use of such a procedure......In aperture problems, integral equations for equivalent currents are often found by enforcing matching of equivalent fields. The enforcement is made in the aperture surface region adjoining the two volumes on each side of the aperture. In the case of an aperture in a planar perfectly conducting...... shows that equivalent currents can be found by a consideration of only one of the two volumes into which the aperture plane divides the space. Furthermore, from a consideration of an automatic matching at the aperture, additional information about tangential as well as normal field components...

  17. Equivalent linearization of nonlinear forces

    Science.gov (United States)

    Meng, Guang; Xue, Zhongqing

    1987-07-01

    A method used for equivalent linearization of the two orthogonal squeeze-film forces is extended here to the general case of n degrees of freedom and n components of nonlinear forces, and the expressions for equivalent linear coefficients are derived. Nonlinear forces can be linearized by the methods of Fourier expansion, active and reactive powers, or mean-square error. The n components of nonlinear forces can all be expressed formally as the sum of an average force, a linear spring force, and a linear damping force. This paper also gives a flow chart for calculating the steady-state responses of a nonlinear system with many degrees of freedom, using the method of equivalent linearization. The resulting saving in computation time is demonstrated by a numerical example of a flexible rotor-bearing system with a noncentralized squeeze-film damper.

  18. TNT Equivalency of Bulk Nitrocellulose

    Science.gov (United States)

    1981-03-01

    Whien Dato Enlotod) &,1W SUMMARY Nitrocellulose, 13.157 nitrogen MIL-N-244A Grade C (Lot number RAD78F0015027) was detonated in configurations...weight factored out, the calculated TNT equivalencies were tabularized and plotted as functions of sample scaled distance. TEST RESULTS Data sheets for

  19. Comments on field equivalence principles

    DEFF Research Database (Denmark)

    Appel-Hansen, Jørgen

    1987-01-01

    It is pointed Out that often-used arguments based on a short-circuit concept in presentations of field equivalence principles are not correct. An alternative presentation based on the uniqueness theorem is given. It does not contradict the results obtained by using the short-circuit concept...

  20. EQUIVALENCE VERSUS NON-EQUIVALENCE IN ECONOMIC TRANSLATION

    Directory of Open Access Journals (Sweden)

    Cristina, Chifane

    2012-01-01

    Full Text Available This paper aims at highlighting the fact that “equivalence” represents a concept worth revisiting and detailing upon when tackling the translation process of economic texts both from English into Romanian and from Romanian into English. Far from being exhaustive, our analysis will focus upon the problems arising from the lack of equivalence at the word level. Consequently, relevant examples from the economic field will be provided to account for the following types of non-equivalence at word level: culturespecific concepts; the source language concept is not lexicalised in the target language; the source language word is semantically complex; differences in physical and interpersonal perspective; differences in expressive meaning; differences in form; differences in frequency and purpose of using specific forms and the use of loan words in the source text. Likewise, we shall illustrate a number of translation strategies necessary to deal with the afore-mentioned cases of non-equivalence: translation by a more general word (superordinate; translation by a more neutral/less expressive word; translation by cultural substitution; translation using a loan word or loan word plus explanation; translation by paraphrase using a related word; translation by paraphrase using unrelated words; translation by omission and translation by illustration.

  1. Equivalent statistics and data interpretation.

    Science.gov (United States)

    Francis, Gregory

    2017-08-01

    Recent reform efforts in psychological science have led to a plethora of choices for scientists to analyze their data. A scientist making an inference about their data must now decide whether to report a p value, summarize the data with a standardized effect size and its confidence interval, report a Bayes Factor, or use other model comparison methods. To make good choices among these options, it is necessary for researchers to understand the characteristics of the various statistics used by the different analysis frameworks. Toward that end, this paper makes two contributions. First, it shows that for the case of a two-sample t test with known sample sizes, many different summary statistics are mathematically equivalent in the sense that they are based on the very same information in the data set. When the sample sizes are known, the p value provides as much information about a data set as the confidence interval of Cohen's d or a JZS Bayes factor. Second, this equivalence means that different analysis methods differ only in their interpretation of the empirical data. At first glance, it might seem that mathematical equivalence of the statistics suggests that it does not matter much which statistic is reported, but the opposite is true because the appropriateness of a reported statistic is relative to the inference it promotes. Accordingly, scientists should choose an analysis method appropriate for their scientific investigation. A direct comparison of the different inferential frameworks provides some guidance for scientists to make good choices and improve scientific practice.

  2. Equivalence relations of AF-algebra extensions

    Indian Academy of Sciences (India)

    In this paper, we consider equivalence relations of *-algebra extensions and describe the relationship between the isomorphism equivalence and the unitary equivalence. We also show that a certain group homomorphism is the obstruction for these equivalence relations to be the same.

  3. Therapeutic Nanodevices

    Science.gov (United States)

    Lee, Stephen; Ruegsegger, Mark; Barnes, Philip; Smith, Bryan; Ferrari, Mauro

    Therapeutic nanotechnology offers minimally invasive therapies with high densities of function concentrated in small volumes, features that may reduce patient morbidity and mortality. Unlike other areas of nanotechnology, novel physical properties associated with nanoscale dimensionality are not the raison d'être of therapeutic nanotechnology, whereas the aggregation of multiple biochemical (or comparably precise) functions into controlled nanoarchitectures is. Multifunctionality is a hallmark of emerging nanotherapeutic devices, and multifunctionality can allow nanotherapeutic devices to perform multistep work processes, with each functional component contributing to one or more nanodevice subroutine such that, in aggregate, subroutines sum to a cogent work process. Cannonical nanotherapeutic subroutines include tethering (targeting) to sites of disease, dispensing measured doses of drug (or bioactive compound), detection of residual disease after therapy and communication with an external clinician/operator. Emerging nanotherapeutics thus blur the boundaries between medical devices and traditional pharmaceuticals. Assembly of therapeutic nanodevices generally exploits either (bio)material self-assembly properties or chemoselective bioconjugation techniques, or both. Given the complexity, composition, and the necessity for their tight chemical and structural definition inherent in the nature of nanotherapeutics, their cost of goods (COGs) might exceed that of (already expensive) biologics. Early therapeutic nanodevices will likely be applied to disease states which exhibit significant unmet patient need (cancer and cardiovascular disease), while application to other disease states well-served by conventional therapy may await perfection of nanotherapeutic design and assembly protocols.

  4. Carbon Equivalent and Maximum Hardness

    OpenAIRE

    Haruyoshi, Suzuki; Head Office, Nippon Steel Corporation

    1984-01-01

    The accuracy of formulae for estimating the maximum hardness values of the HAZ from chemical composition and cooling time for welds in high strength steel is discussed and a new formula. NSC-S, is proposed which uses only C%, Pcm% and cooling time for the purpose of satisfactory accuracy. IIW CE and Ito-Bessyo Pcm carbon equivalent alone are not satisfactory in establishing Hmax values. The former is good only for slow cooling, t8/5 longer than 10 seconds, while the latter is good only for fa...

  5. [Lscr]0-equivalence of maps

    Science.gov (United States)

    Gaffney, Terence

    2000-05-01

    We use the theory of the integral closure of an ideal to study the equivalence of map-germs under C0 coordinate changes in the target. We also derive a formula for the number of double points of a map germ from Cn [rightward arrow] C2n in terms of the Segre number of dimension 0 of an ideal associated to the double point locus of f, and the number of Whitney umbrellas of the composition of f with a generic projection to C2n[minus sign]1.

  6. ROMANIC EQUIVALENTS FOR LATIN IDIOMS

    Directory of Open Access Journals (Sweden)

    Dr. Stefan DUMITRU

    2010-11-01

    Full Text Available In this study we set forth to present several of the most important aspects regarding the contrastive analysis of a well-defined number of Latin idioms in parallel with their Romanic counterparts (in French, Italian, Spanish and Romanian. Our intent was not to discover, in the Romanic space, all the equivalents of the phrases that form the corpus we work with, for reasons pertaining to material restrictions, but to discuss, based on a certain number of units, the different types of issues they may point to. The most important is to establish the relation between the idiomatic expressions in Latin and their correspondents in the above mentioned languages, regarding their inner form, their meaning and their structure.

  7. Expanding the Interaction Equivalency Theorem

    Directory of Open Access Journals (Sweden)

    Brenda Cecilia Padilla Rodriguez

    2015-06-01

    Full Text Available Although interaction is recognised as a key element for learning, its incorporation in online courses can be challenging. The interaction equivalency theorem provides guidelines: Meaningful learning can be supported as long as one of three types of interactions (learner-content, learner-teacher and learner-learner is present at a high level. This study sought to apply this theorem to the corporate sector, and to expand it to include other indicators of course effectiveness: satisfaction, knowledge transfer, business results and return on expectations. A large Mexican organisation participated in this research, with 146 learners, 30 teachers and 3 academic assistants. Three versions of an online course were designed, each emphasising a different type of interaction. Data were collected through surveys, exams, observations, activity logs, think aloud protocols and sales records. All course versions yielded high levels of effectiveness, in terms of satisfaction, learning and return on expectations. Yet, course design did not dictate the types of interactions in which students engaged within the courses. Findings suggest that the interaction equivalency theorem can be reformulated as follows: In corporate settings, an online course can be effective in terms of satisfaction, learning, knowledge transfer, business results and return on expectations, as long as (a at least one of three types of interaction (learner-content, learner-teacher or learner-learner features prominently in the design of the course, and (b course delivery is consistent with the chosen type of interaction. Focusing on only one type of interaction carries a high risk of confusion, disengagement or missed learning opportunities, which can be managed by incorporating other forms of interactions.

  8. Equivalence of recursive specifications in process algebra

    NARCIS (Netherlands)

    A.J. van der Poorten (Alf); Y.S. Usenko (Yaroslav)

    2001-01-01

    textabstractWe define an equivalence relation on recursive specifications in process algebra that is model-independent and does not involve an explicit notion of solution. Then we extend this equivalence to the specification language $mu$CRL.

  9. Equivalent damage of loads on pavements

    CSIR Research Space (South Africa)

    Prozzi, JA

    2009-05-26

    Full Text Available This report describes a new methodology for the determination of Equivalent Damage Factors (EDFs) of vehicles with multiple axle and wheel configurations on pavements. The basic premise of this new procedure is that "equivalent pavement response...

  10. Behavioural equivalence for infinite systems - Partially decidable!

    DEFF Research Database (Denmark)

    Sunesen, Kim; Nielsen, Mogens

    1996-01-01

    languages with two generalizations based on traditional approaches capturing non-interleaving behaviour, pomsets representing global causal dependency, and locality representing spatial distribution of events. We first study equivalences on Basic Parallel Processes, BPP, a process calculus equivalent...

  11. Discovering Classes of Strongly Equivalent Logic Programs

    OpenAIRE

    Chen, Y.; Lin, F.

    2011-01-01

    In this paper we apply computer-aided theorem discovery technique to discover theorems about strongly equivalent logic programs under the answer set semantics. Our discovered theorems capture new classes of strongly equivalent logic programs that can lead to new program simplification rules that preserve strong equivalence. Specifically, with the help of computers, we discovered exact conditions that capture the strong equivalence between a rule and the empty set, between two rules, between t...

  12. An Equivalent Fracture Modeling Method

    Science.gov (United States)

    Li, Shaohua; Zhang, Shujuan; Yu, Gaoming; Xu, Aiyun

    2017-12-01

    3D fracture network model is built based on discrete fracture surfaces, which are simulated based on fracture length, dip, aperture, height and so on. The interesting area of Wumishan Formation of Renqiu buried hill reservoir is about 57 square kilometer and the thickness of target strata is more than 2000 meters. In addition with great fracture density, the fracture simulation and upscaling of discrete fracture network model of Wumishan Formation are very intense computing. In order to solve this problem, a method of equivalent fracture modeling is proposed. First of all, taking the fracture interpretation data obtained from imaging logging and conventional logging as the basic data, establish the reservoir level model, and then under the constraint of reservoir level model, take fault distance analysis model as the second variable, establish fracture density model by Sequential Gaussian Simulation method. Increasing the width, height and length of fracture, at the same time decreasing its density in order to keep the similar porosity and permeability after upscaling discrete fracture network model. In this way, the fracture model of whole interesting area can be built within an accepted time.

  13. The effective theory of Borel equivalence relations

    DEFF Research Database (Denmark)

    Fokina, E.B.; Friedman, S.-D.; Törnquist, Asger Dag

    2010-01-01

    equality on ω is above equality on P (ω), the power set of ω, and any Borel equivalence relation strictly above equality on the reals is above equality modulo finite on P (ω). In this article we examine the effective content of these and related results by studying effectively Borel equivalence relations......The study of Borel equivalence relations under Borel reducibility has developed into an important area of descriptive set theory. The dichotomies of Silver [20] and Harrington, Kechris and Louveau [6] show that with respect to Borel reducibility, any Borel equivalence relation strictly above...... under effectively Borel reducibility. The resulting structure is complex, even for equivalence relations with finitely many equivalence classes. However use of Kleene's O as a parameter is sufficient to restore the picture from the noneffective setting. A key lemma is that of the existence of two...

  14. The Complexity of Identifying Large Equivalence Classes

    DEFF Research Database (Denmark)

    Skyum, Sven; Frandsen, Gudmund Skovbjerg; Miltersen, Peter Bro

    1999-01-01

    We prove that at least 3k−4/k(2k−3)(n/2) – O(k)equivalence tests and no more than 2/k (n/2) + O(n) equivalence tests are needed in the worst case to identify the equivalence classes with at least k members in set of n elements. The upper bound is an improvement by a factor 2 compared to known res...

  15. 21 CFR 26.9 - Equivalence determination.

    Science.gov (United States)

    2010-04-01

    ... RECOGNITION OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS... Specific Sector Provisions for Pharmaceutical Good Manufacturing Practices § 26.9 Equivalence determination...

  16. 21 CFR 26.6 - Equivalence assessment.

    Science.gov (United States)

    2010-04-01

    ... OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS... Specific Sector Provisions for Pharmaceutical Good Manufacturing Practices § 26.6 Equivalence assessment...

  17. Novel bioequivalence approach for narrow therapeutic index drugs.

    Science.gov (United States)

    Yu, L X; Jiang, W; Zhang, X; Lionberger, R; Makhlouf, F; Schuirmann, D J; Muldowney, L; Chen, M-L; Davit, B; Conner, D; Woodcock, J

    2015-03-01

    Narrow therapeutic index drugs are defined as those drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity. The US Food and Drug Administration proposes that the bioequivalence of narrow therapeutic index drugs be determined using a scaling approach with a four-way, fully replicated, crossover design study in healthy subjects that permits the simultaneous equivalence comparison of the mean and within-subject variability of the test and reference products. The proposed bioequivalence limits for narrow therapeutic index drugs of 90.00%-111.11% would be scaled based on the within-subject variability of the reference product. The proposed study design and data analysis should provide greater assurance of therapeutic equivalence of narrow therapeutic index drug products. © 2014 American Society for Clinical Pharmacology and Therapeutics.

  18. Therapeutic misadventure.

    Science.gov (United States)

    Langford, N J

    2010-10-01

    Therapeutic misadventure can be defined as an injury or an adverse event caused by medical management rather than by an underlying disease. Within the National Health Service there were over 86,000 reported adverse incidents in 2007. In the USA medication errors have been rated as the fourth highest cause of death. Unfortunately one of the greatest contributors to iatrogenic injury is human error. The potential types of misadventure are infinite. Medication errors are a major part of this, being responsible for over 70% of cases that cause serious harm. However, many medication errors caused by slips, lapses, technical errors and mistakes are preventable; intentional violations of safe operating procedures are not. While medication errors were tolerated by society in the past, the readiness to institute criminal proceedings against health-care professionals has increased greatly in the UK over the last decade. The medication process consists of writing prescriptions, dispensing the product, administering it and monitoring its effects. Prescription errors arise owing to incomplete information, lack of appropriate labelling, environmental factors and human blunders. Even with a perfect prescription the right medication must be dispensed and appropriately labelled. Dispensing errors are not uncommon and may be compounded by non-clinical considerations. Administration of a drug by injection is one of the most dangerous aspects of the medication process, especially in inexperienced hands. The final component of medication supply is monitoring the effect of the medication. With short courses of medication such monitoring is easy, but with long-term medication, particularly with potent drugs where the margin between efficacy and toxicity is small, active procedures may be required to ensure toxicity does not ensue. Despite the endeavour of health-care professions to stick to the rule of 'first, do no harm', in reality this is difficult to achieve all of the time. When

  19. [Nine Equivalents of Nursing Manpower Use Score (NEMS): a study of its historical process].

    Science.gov (United States)

    Canabarro, Simone Travi; Velozo, Kelly Dayane Stochero; Eidt, Olga Rosária; Piva, Jefferson Pedro; Garcia, Pedro Celiny Ramos

    2010-09-01

    This study aims to describe, through an integrative review of literature, the historical trajectory of therapeutic intervention scores with emphasis on Nine Equivalents of Nursing Manpower Use Score in Intensive Care Units. The descriptors "Intensive care units" and "scales" were looked up in publications issued between 2000 and 2009. The terms selected were: "Nine Equivalents of Nursing Manpower Use Score" or "NEMS", "Unidade de Terapia Intensiva", "Therapeutic Intervention Scoring System-76", "Therapeutic Intervention Scoring System-28 or "TISS-28". As to the publications, "Medical Literature Analysis and Retrieval System Online" (MEDLINE) and "Literatura Latino-Americana e do Caribe em Ciências da Saúde" (LILACS) were selected Among the 295 papers reviewed, 18 were chosen, of which 55,5% were in English. The studies deal with NEMS (33,3%), Therapeutic Intervention Scoring System-76 (11,1%), TISS-28 (33,3%), among others. Research emphasized that NEMS has been a useful, operational and succinct tool.

  20. 46 CFR 176.930 - Equivalents.

    Science.gov (United States)

    2010-10-01

    ...) INSPECTION AND CERTIFICATION International Convention for Safety of Life at Sea, 1974, as Amended (SOLAS) § 176.930 Equivalents. As outlined in Chapter I (General Provisions) Regulation 5, of SOLAS, the... required by SOLAS regulations if satisfied that such equivalent is at least as effective as that required...

  1. 46 CFR 115.930 - Equivalents.

    Science.gov (United States)

    2010-10-01

    ... International Convention for Safety of Life at Sea, 1974, as Amended (SOLAS) § 115.930 Equivalents. In accordance with Chapter I (General Provisions) Regulation 5, of SOLAS, the Commandant may accept an... the SOLAS regulations if satisfied that such equivalent is at least as effective as that required by...

  2. Flow equivalence and isotopy for subshifts

    DEFF Research Database (Denmark)

    Boyle, Mike; Carlsen, Toke Meier; Eilers, Søren

    2017-01-01

    We study basic properties of flow equivalence on one-dimensional compact metric spaces with a particular emphasis on isotopy in the group of (self-) flow equivalences on such a space. In particular, we show that such an orbit-preserving map is not always an isotopy, but that this always is the case...

  3. What is Metaphysical Equivalence? | Miller | Philosophical Papers

    African Journals Online (AJOL)

    In this paper I argue that if we are judiciously to resolve disputes about whether theories are equivalent or not, we need to develop testable criteria that will give us epistemic access to the obtaining of the relation of metaphysical equivalence holding between those theories. I develop such 'diagnostic' criteria. I argue that ...

  4. What is Metaphysical Equivalence? | Miller | Philosophical Papers

    African Journals Online (AJOL)

    Theories are metaphysically equivalent just if there is no fact of the matter that could render one theory true and the other false. In this paper I argue that if we are judiciously to resolve disputes about whether theories are equivalent or not, we need to develop testable criteria that will give us epistemic access to the obtaining ...

  5. 49 CFR 38.2 - Equivalent facilitation.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Equivalent facilitation. 38.2 Section 38.2 Transportation Office of the Secretary of Transportation AMERICANS WITH DISABILITIES ACT (ADA) ACCESSIBILITY SPECIFICATIONS FOR TRANSPORTATION VEHICLES General § 38.2 Equivalent facilitation. Departures from particular...

  6. Bioengineering lantibiotics for therapeutic success

    Directory of Open Access Journals (Sweden)

    Des eField

    2015-11-01

    Full Text Available Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to alter, and even enhance, the antimicrobial activity, antibacterial spectrum and physico-chemical properties, including heat stability, solubility, diffusion and protease resistance, of these compounds. Additionally, we discuss the potential applications of these lantibiotics for use as therapeutics.

  7. Beyond Language Equivalence on Visibly Pushdown Automata

    DEFF Research Database (Denmark)

    Srba, Jiri

    2009-01-01

    We study (bi)simulation-like preorder/equivalence checking on the class of visibly pushdown automata and its natural subclasses visibly BPA (Basic Process Algebra) and visibly one-counter automata. We describe generic methods for proving complexity upper and lower bounds for a number of studied...... preorders and equivalences like simulation, completed simulation, ready simulation, 2-nested simulation preorders/equivalences and bisimulation equivalence. Our main results are that all the mentioned equivalences and preorders are EXPTIME-complete on visibly pushdown automata, PSPACE-complete on visibly...... one-counter automata and P-complete on visibly BPA. Our PSPACE lower bound for visibly one-counter automata improves also the previously known DP-hardness results for ordinary one-counter automata and one-counter nets. Finally, we study regularity checking problems for visibly pushdown automata...

  8. Equivalence in Ventilation and Indoor Air Quality

    Energy Technology Data Exchange (ETDEWEB)

    Sherman, Max; Walker, Iain; Logue, Jennifer

    2011-08-01

    We ventilate buildings to provide acceptable indoor air quality (IAQ). Ventilation standards (such as American Society of Heating, Refrigerating, and Air-Conditioning Enginners [ASHRAE] Standard 62) specify minimum ventilation rates without taking into account the impact of those rates on IAQ. Innovative ventilation management is often a desirable element of reducing energy consumption or improving IAQ or comfort. Variable ventilation is one innovative strategy. To use variable ventilation in a way that meets standards, it is necessary to have a method for determining equivalence in terms of either ventilation or indoor air quality. This study develops methods to calculate either equivalent ventilation or equivalent IAQ. We demonstrate that equivalent ventilation can be used as the basis for dynamic ventilation control, reducing peak load and infiltration of outdoor contaminants. We also show that equivalent IAQ could allow some contaminants to exceed current standards if other contaminants are more stringently controlled.

  9. Studies on the Neutron Radiation Damage Equivalence

    Directory of Open Access Journals (Sweden)

    ZOU De-hui

    2015-01-01

    Full Text Available To establish a unified standard of the evaluation of different sources of radiation damage, the neutron radiation damage equivalent standard source was determined both at home and abroad, and a lot of equivalence research work was done for making weapons anti neutron radiation performance examination and acceptance basis. The theoretical research progress was combed according to the relationship between the displacement damage function and the radiation source spectra ,and the experimental research progress was combed from the basic experimental methods, the controlling trend of effect parameters and field parameters. The experiment method to reduce the uncertainty was discussed, and present the research directions of radiation damage equivalence.

  10. Distinguishing Provenance Equivalence of Earth Science Data

    Science.gov (United States)

    Tilmes, Curt; Yesha, Ye; Halem, M.

    2010-01-01

    Reproducibility of scientific research relies on accurate and precise citation of data and the provenance of that data. Earth science data are often the result of applying complex data transformation and analysis workflows to vast quantities of data. Provenance information of data processing is used for a variety of purposes, including understanding the process and auditing as well as reproducibility. Certain provenance information is essential for producing scientifically equivalent data. Capturing and representing that provenance information and assigning identifiers suitable for precisely distinguishing data granules and datasets is needed for accurate comparisons. This paper discusses scientific equivalence and essential provenance for scientific reproducibility. We use the example of an operational earth science data processing system to illustrate the application of the technique of cascading digital signatures or hash chains to precisely identify sets of granules and as provenance equivalence identifiers to distinguish data made in an an equivalent manner.

  11. Nuclear Regulatory Commission equivalency evaluation report

    Energy Technology Data Exchange (ETDEWEB)

    Garvin, L.J.

    1995-10-01

    This paper provides the basis for concluding that using the seismic design criteria, defined in DOE order 4580.28, Natural Phenomena Hazards Mitigation, and its implementing standards provides safety equivalent to NRC criteria.

  12. Equivalence Principle, Higgs Boson and Cosmology

    Directory of Open Access Journals (Sweden)

    Mauro Francaviglia

    2013-05-01

    Full Text Available We discuss here possible tests for Palatini f(R-theories together with their implications for different formulations of the Equivalence Principle. We shall show that Palatini f(R-theories obey the Weak Equivalence Principle and violate the Strong Equivalence Principle. The violations of the Strong Equivalence Principle vanish in vacuum (and purely electromagnetic solutions as well as on short time scales with respect to the age of the universe. However, we suggest that a framework based on Palatini f(R-theories is more general than standard General Relativity (GR and it sheds light on the interpretation of data and results in a way which is more model independent than standard GR itself.

  13. Equivalence principle and bound kinetic energy.

    Science.gov (United States)

    Hohensee, Michael A; Müller, Holger; Wiringa, R B

    2013-10-11

    We consider the role of the internal kinetic energy of bound systems of matter in tests of the Einstein equivalence principle. Using the gravitational sector of the standard model extension, we show that stringent limits on equivalence principle violations in antimatter can be indirectly obtained from tests using bound systems of normal matter. We estimate the bound kinetic energy of nucleons in a range of light atomic species using Green's function Monte Carlo calculations, and for heavier species using a Woods-Saxon model. We survey the sensitivities of existing and planned experimental tests of the equivalence principle, and report new constraints at the level of between a few parts in 10(6) and parts in 10(8) on violations of the equivalence principle for matter and antimatter.

  14. REFractions: The Representing Equivalent Fractions Game

    Science.gov (United States)

    Tucker, Stephen I.

    2014-01-01

    Stephen Tucker presents a fractions game that addresses a range of fraction concepts including equivalence and computation. The REFractions game also improves students' fluency with representing, comparing and adding fractions.

  15. Dark matter and the equivalence principle

    Science.gov (United States)

    Frieman, Joshua A.; Gradwohl, Ben-Ami

    1993-01-01

    A survey is presented of the current understanding of dark matter invoked by astrophysical theory and cosmology. Einstein's equivalence principle asserts that local measurements cannot distinguish a system at rest in a gravitational field from one that is in uniform acceleration in empty space. Recent test-methods for the equivalence principle are presently discussed as bases for testing of dark matter scenarios involving the long-range forces between either baryonic or nonbaryonic dark matter and ordinary matter.

  16. The principle of equivalence reconsidered: assessing the relevance of the principle of equivalence in prison medicine.

    Science.gov (United States)

    Jotterand, Fabrice; Wangmo, Tenzin

    2014-01-01

    In this article we critically examine the principle of equivalence of care in prison medicine. First, we provide an overview of how the principle of equivalence is utilized in various national and international guidelines on health care provision to prisoners. Second, we outline some of the problems associated with its applications, and argue that the principle of equivalence should go beyond equivalence to access and include equivalence of outcomes. However, because of the particular context of the prison environment, third, we contend that the concept of "health" in equivalence of health outcomes needs conceptual clarity; otherwise, it fails to provide a threshold for healthy states among inmates. We accomplish this by examining common understandings of the concepts of health and disease. We conclude our article by showing why the conceptualization of diseases as clinical problems provides a helpful approach in the delivery of health care in prison.

  17. Conotoxins that Confer Therapeutic Possibilities

    Directory of Open Access Journals (Sweden)

    John A. C. Archer

    2012-06-01

    Full Text Available Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and diseased states, as well as being a collection of compounds of potential pharmacological use in their own right. Examples include the United States Food and Drug Administration (FDA approved pharmaceutical drug, Ziconotide (Prialt®; Elan Pharmaceuticals, Inc. that is the synthetic equivalent of the naturally occurring ω-conotoxin MVIIA, whilst several other conotoxins are currently being used as standard research tools and screened as potential therapeutic drugs in pre-clinical or clinical trials. These developments highlight the importance of driving conotoxin-related research. A PubMed query from 1 January 2007 to 31 August 2011 combined with hand-curation of the retrieved articles allowed for the collation of 98 recently identified conotoxins with therapeutic potential which are selectively discussed in this review. Protein sequence similarity analysis tentatively assigned uncharacterized conotoxins to predicted functional classes. Furthermore, conotoxin therapeutic potential for neurodegenerative disorders (NDD was also inferred.

  18. Conotoxins that confer therapeutic possibilities

    KAUST Repository

    Essack, Magbubah

    2012-06-04

    Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and diseased states, as well as being a collection of compounds of potential pharmacological use in their own right. Examples include the United States Food and Drug Administration (FDA) approved pharmaceutical drug, Ziconotide (Prialt; Elan Pharmaceuticals, Inc.) that is the synthetic equivalent of the naturally occurring ?-conotoxin MVIIA, whilst several other conotoxins are currently being used as standard research tools and screened as potential therapeutic drugs in pre-clinical or clinical trials. These developments highlight the importance of driving conotoxin-related research. A PubMed query from 1 January 2007 to 31 August 2011 combined with hand-curation of the retrieved articles allowed for the collation of 98 recently identified conotoxins with therapeutic potential which are selectively discussed in this review. Protein sequence similarity analysis tentatively assigned uncharacterized conotoxins to predicted functional classes. Furthermore, conotoxin therapeutic potential for neurodegenerative disorders (NDD) was also inferred. 2012 by the authors; licensee MDPI.

  19. Orientifold Planar Equivalence: The Chiral Condensate

    DEFF Research Database (Denmark)

    Armoni, Adi; Lucini, Biagio; Patella, Agostino

    2008-01-01

    in SU($N$) Yang-Mills in the large $N$ limit. Then, we compute numerically those quenched condensates for $N$ up to 8. After separating the even from the odd corrections in $1/N$, we are able to show that our data support the equivalence; however, unlike other quenched observables, subleading terms......The recently introduced orientifold planar equivalence is a promising tool for solving non-perturbative problems in QCD. One of the predictions of orientifold planar equivalence is that the chiral condensates of a theory with $N_f$ flavours of Dirac fermions in the symmetric (or antisymmetric......) representation and $N_f$ flavours of Majorana fermions in the adjoint representation have the same large $N$ value for any value of the mass of the (degenerate) fermions. Assuming the invariance of the theory under charge conjugation, we prove this statement on the lattice for staggered quenched condensates...

  20. Equivalent circuit analysis of terahertz metamaterial filters

    KAUST Repository

    Zhang, Xueqian

    2011-01-01

    An equivalent circuit model for the analysis and design of terahertz (THz) metamaterial filters is presented. The proposed model, derived based on LMC equivalent circuits, takes into account the detailed geometrical parameters and the presence of a dielectric substrate with the existing analytic expressions for self-inductance, mutual inductance, and capacitance. The model is in good agreement with the experimental measurements and full-wave simulations. Exploiting the circuit model has made it possible to predict accurately the resonance frequency of the proposed structures and thus, quick and accurate process of designing THz device from artificial metamaterials is offered. ©2011 Chinese Optics Letters.

  1. Fiscal adjustments in Europe and Ricardian equivalence

    Directory of Open Access Journals (Sweden)

    V. DE BONIS

    1998-09-01

    Full Text Available According to the ‘Ricardian’ equivalence hypothesis, consumption is dependent on permanent disposable income and current deficits are equivalent to future tax payments. This hypothesis is tested on 14 European countries in the 1990s. The relationships between private sector savings and general government deficit, and the GDP growth rate and the unemployment rate are determined. The results show the change in consumers' behaviour with respect to government deficit, and that expectations of an increase in future wealth are no longer associated with a decrease in deficit.

  2. TRANSLATION EQUIVALENCE AND CONTEXT CONSIDERATION IN GOOGLE

    Directory of Open Access Journals (Sweden)

    I Made Sena Darmasetiyawan

    2014-05-01

    Full Text Available This article aims at describing the translation methods of this tool through equivalence and context consideration which also suggest the account of language database within. The data was taken from Google Translate because it is one of the most reliable tools of translation through internet service. Results showed that there are three basic reference methods of frequency, graphology, and contextual matching database in the translation. Context in discourse and equivalence in translation are used in order to analyze the extent of this consideration.

  3. A Logical Characterisation of Static Equivalence

    DEFF Research Database (Denmark)

    Hüttel, Hans; Pedersen, Michael D.

    2007-01-01

    The work of Abadi and Fournet introduces the notion of a frame to describe the knowledge of the environment of a cryptographic protocol. Frames are lists of terms; two frames are indistinguishable under the notion of static equivalence if they satisfy the same equations on terms. We present a first......-order logic for frames with quantification over environment knowledge which, under certain general conditions, characterizes static equivalence and is amenable to construction of characteristic formulae. The logic can be used to reason about environment knowledge and can be adapted to a particular application...

  4. High School Equivalency Testing in Arizona. Forum: Responding to Changes in High School Equivalency Testing

    Science.gov (United States)

    Hart, Sheryl

    2015-01-01

    For decades, the state of Arizona has used the General Educational Development (GED) Test to award the Arizona High School Equivalency (HSE) Diploma, as the GED Test was the only test available, recognized and accepted in the United States as the measure by which adults could demonstrate the educational attainment equivalent to high school…

  5. Fuel Cell Equivalent Electric Circuit Parameter Mapping

    DEFF Research Database (Denmark)

    Jeppesen, Christian; Zhou, Fan; Andreasen, Søren Juhl

    In this work a simple model for a fuel cell is investigated for diagnostic purpose. The fuel cell is characterized, with respect to the electrical impedance of the fuel cell at non-faulty conditions and under variations in load current. Based on this the equivalent electrical circuit parameters can...

  6. Identifiability and Equivalence of GLLIRM Models

    Science.gov (United States)

    Revuelta, Javier

    2009-01-01

    The generalized logit-linear item response model (GLLIRM) is a linearly constrained nominal categories model (NCM) that computes the scale and intercept parameters for categories as a weighted sum of basic parameters. This paper addresses the problems of the identifiability of the basic parameters and the equivalence between different GLLIRM…

  7. Confluence Modulo Equivalence in Constraint Handling Rules

    DEFF Research Database (Denmark)

    Christiansen, Henning; Kirkeby, Maja Hanne

    2014-01-01

    Previous results on confluence for Constraint Handling Rules, CHR, are generalized to take into account user-defined state equivalence relations. This allows a much larger class of programs to enjoy the ad- vantages of confluence, which include various optimization techniques and simplified corre...

  8. interpratation: of equivalences and cultural untranslatability

    African Journals Online (AJOL)

    jgmweri

    interpretation?; How does lack of equivalences affect interpretation? Key words: Sign Language, Interpretation, Translation, linguistics, context ... World Federation of the Deaf (WFD's) vision 2020 in which it envisions that by the year ... sign 1b) can mean MANY or A LOT: 1c) can have three meaning i.e. FOR EXAMPLE,.

  9. An Equivalent Circuit for Landau Damping

    DEFF Research Database (Denmark)

    Pécseli, Hans

    1976-01-01

    An equivalent circuit simulating the effect of Landau damping in a stable plasma‐loaded parallel‐plate capacitor is presented. The circuit contains a double infinity of LC components. The transition from stable to unstable plasmas is simulated by the introduction of active elements into the circuit....

  10. On Behavioral Equivalence of Rational Representations

    NARCIS (Netherlands)

    Trentelman, Harry L.; Willems, JC; Hara, S; Ohta, Y; Fujioka, H

    2010-01-01

    This article deals with the equivalence of representations of behaviors of linear differential systems In general. the behavior of a given linear differential system has many different representations. In this paper we restrict ourselves to kernel representations and image representations Two kernel

  11. Equivalence domination in graphs | Arumugam | Quaestiones ...

    African Journals Online (AJOL)

    Click on the link to view the abstract. Keywords: Equivalence domination, total domination, P3-forming set. Quaestiones Mathematicae 36(2013), 331-340. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.2989/16073606.2013.779959 · AJOL African ...

  12. A Criticism of Healthy-years Equivalents

    NARCIS (Netherlands)

    P.P. Wakker (Peter)

    1996-01-01

    textabstractThe following questions describe the scope of this paper. When decision trees are used to analyze optimal decisions, should end nodes be evaluated on the basis of QALYs or on the basis of healthy-years equivalents? Which measures should be used in communications with others, e.g.,

  13. A criticism of healthy-years equivalents

    NARCIS (Netherlands)

    Wakker, P.P.

    1996-01-01

    The following questions describe the scope of this paper. When decision trees are used to analyze optimal decisions, should end nodes be evaluated on the basis of QALYs or on the basis of healthy-years equivalents? Which measures should be used in communication with others, e.g., patients? Which of

  14. Conservation Laws, Equivalence Principle and Forbidden Radiation ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 3. Conservation Laws, Equivalence Principle and Forbidden Radiation Modes. Cihan Saçlioğlu. General ... Author Affiliations. Cihan Saçlioğlu1. Faculty of Engineering and Natural Sciences, Sabanci University, 81474 Tuzla, Istanbul, Turkey.

  15. Conservation Laws, Equivalence Principle and Forbidden Radiation ...

    Indian Academy of Sciences (India)

    There are standard proofs showing there can be no monopole electromagnetic radiation and no dipole gravitational radiation. We supplement these with a global topological argument for the former, and a local argument based directly on the principle of equivalence for the latter. 1. Introduction: Wave and Particle Pictures ...

  16. Bilingual Dictionaries and Communicative Equivalence for a ...

    African Journals Online (AJOL)

    Speakers in a multilingual society often employ a bilingual dictionary as the only instrument to meet their lexicographic needs. This implies that a bilingual dictionary becomes a poly functional instrument, presenting more information than just translation equivalents. This article focuses on the contents and the presentation ...

  17. Stimulus Equivalence in Rudimentary Reading and Spelling.

    Science.gov (United States)

    Mackay, Harry A.

    1985-01-01

    Programs were designed to teach three severely retarded adolescents to use individual anagram letters to construct the appropriate color words when shown color patches. After learning visual equivalences between colors and printed words, Ss demonstrated auditory reading-comprehension (matching printed words to dictated words) and oral reading…

  18. 21 CFR 26.39 - Equivalence assessment.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Equivalence assessment. 26.39 Section 26.39 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL MUTUAL RECOGNITION OF PHARMACEUTICAL GOOD MANUFACTURING PRACTICE REPORTS, MEDICAL DEVICE QUALITY SYSTEM AUDIT REPORTS, AND CERTAIN MEDICAL DEVICE PRODUCT...

  19. CP Violation, Neutral Currents, and Weak Equivalence

    Science.gov (United States)

    Fitch, V. L.

    1972-03-23

    Within the past few months two excellent summaries of the state of our knowledge of the weak interactions have been presented. Correspondingly, we will not attempt a comprehensive review but instead concentrate this discussion on the status of CP violation, the question of the neutral currents, and the weak equivalence principle.

  20. Confluence Modulo Equivalence in Constraint Handling Rules

    DEFF Research Database (Denmark)

    Christiansen, Henning; Kirkeby, Maja Hanne

    2015-01-01

    Previous results on confluence for Constraint Handling Rules, CHR, are generalized to take into account user-defined state equivalence relations. This allows a much larger class of programs to enjoy the advantages of confluence, which include various optimization techniques and simplified...

  1. interpratation: of equivalences and cultural untranslatability

    African Journals Online (AJOL)

    jgmweri

    communicative situation – this involves not only linguistic and cultural competence but ... Diversity in language use – how does it affect interpretation? ; Does direct and indirect use of language, social customs and relationships, how people express emotions have any ..... 1.3.3 Grammatical- Syntactical Equivalences.

  2. Four equivalent lot-sizing models

    NARCIS (Netherlands)

    W. van den Heuvel (Wilco); A.P.M. Wagelmans (Albert)

    2007-01-01

    textabstractWe study the following lot-sizing models that recently appeared in the literature: a lot-sizing model with a remanufacturing option, a lot-sizing model with production time windows, and a lot-sizing model with cumulative capacities. We show the equivalence of these models with a

  3. Contextual dependencies in a stimulus equivalence paradigm

    NARCIS (Netherlands)

    Dibbets, P.; Maes, J.H.R.; Vossen, J.M.H.

    2002-01-01

    Two experiments with human subjects assessed contextual dependencies in a stimulus equivalence paradigm. Subjects learned to form two sets of stimuli in a matching-to-sample training procedure. Each set was presented against one of two different background colours, the contextual cues. At test, the

  4. Equivalent configurations of optical transformation media.

    Science.gov (United States)

    Chen, Tungyang; Cheng, Shen-Wen; Weng, Chung-Ning

    2009-11-09

    We demonstrate that a medium consisting of two adjoining distinct layers of transformation materials, corresponding respectively to two linear coordinate transformations, can behave effectively as that of the same region transformed by another linear transformation. The equivalence means that, irrespective of the direction of incident wave, the fields of the medium exterior to the transformed regions of the two configurations are exactly the same. This property can also apply to a domain that is transformed by a piecewise linear transformation function, and to a medium that is mapped by a general curved function. This proof is shown analytically based on a rigorous Fourier-Bessel analysis. The equivalence suggests that, for a given transformed domain, one can find an infinite number of complementary media that altogether can give a desired effective response of certain transformation path.

  5. Orientifold Planar Equivalence: The Quenched Meson Spectrum

    CERN Document Server

    Lucini, Biagio; Patella, Agostino; Rago, Antonio

    2010-01-01

    A numerical study of Orientifold Planar Equivalence is performed in SU(N) Yang-Mills theories for N=2,3,4,6. Quenched meson masses are extracted in the antisymmetric, symmetric and adjoint representations for the pseudoscalar and vector channels. An extrapolation of the vector mass as a function of the pseudoscalar mass to the large-N limit shows that the numerical results agree within errors for the three theories, as predicted by Orientifold Planar Equivalence. As a byproduct of the extrapolation, the size of the corrections up to O(1/N^3) are evaluated. A crucial prerequisite for the extrapolation is the determination of an analytical relationship between the corrections in the symmetric and in the antisymmetric representations, order by order in a 1/N expansion.

  6. Thevenin Equivalent Method for Dynamic Contingency Assessment

    DEFF Research Database (Denmark)

    Møller, Jakob Glarbo; Jóhannsson, Hjörtur; Østergaard, Jacob

    2015-01-01

    A method that exploits Thevenin equivalent representation for obtaining post-contingency steady-state nodal voltages is integrated with a method of detecting post-contingency aperiodic small-signal instability. The task of integrating stability assessment with contingency assessment is challenged...... by the cases of unstable post-contingency conditions. For unstable postcontingency conditions there exists no credible steady-state which can be used for basis of a stability assessment. This paper demonstrates how Thevenin Equivalent methods can be applied in algebraic representation of such bifurcation...... points which may be used in assessment of post-contingency aperiodic small-signal stability. The assessment method is introduced with a numeric example....

  7. Underlining some aspects of the equivalence principle

    Science.gov (United States)

    Benedetto, E.; Feoli, A.

    2017-09-01

    We want to shed light on some discussed aspects of the principle of equivalence. We consider two different phases in the evolution of the principle. We pay attention to the fact that some textbooks do not dwell on the mathematical meaning of ‘locally flat spacetime’, which can confuse students and, occasionally, can also lead to misinterpretations. For example, the non-eliminability of tidal forces, not even locally, may suggest that the equivalence principle is wrong. By contrast, we want to show that this is in perfect agreement with the Einstein geometrical interpretation of spacetime. Finally, in order to check the approximations used in the Gedankenexperiment of an elevator, we estimate explicitly the magnitude of the deflection of light and the effects of tidal forces in a ‘real lift’.

  8. On equivalent resistance of electrical circuits

    Science.gov (United States)

    Kagan, Mikhail

    2015-01-01

    While the standard (introductory physics) way of computing the equivalent resistance of nontrivial electrical circuits is based on Kirchhoff's rules, there is a mathematically and conceptually simpler approach, called the method of nodal potentials, whose basic variables are the values of the electric potential at the circuit's nodes. In this paper, we review the method of nodal potentials and illustrate it using the Wheatstone bridge as an example. We then derive a closed-form expression for the equivalent resistance of a generic circuit, which we apply to a few sample circuits. The result unveils a curious interplay between electrical circuits, matrix algebra, and graph theory and its applications to computer science. The paper is written at a level accessible by undergraduate students who are familiar with matrix arithmetic. Additional proofs and technical details are provided in appendices.

  9. Testing the Equivalence of Regular Languages

    Directory of Open Access Journals (Sweden)

    Marco Almeida

    2009-07-01

    Full Text Available The minimal deterministic finite automaton is generally used to determine regular languages equality. Antimirov and Mosses proposed a rewrite system for deciding regular expressions equivalence of which Almeida et al. presented an improved variant. Hopcroft and Karp proposed an almost linear algorithm for testing the equivalence of two deterministic finite automata that avoids minimisation. In this paper we improve the best-case running time, present an extension of this algorithm to non-deterministic finite automata, and establish a relationship between this algorithm and the one proposed in Almeida et al. We also present some experimental comparative results. All these algorithms are closely related with the recent coalgebraic approach to automata proposed by Rutten.

  10. Quantum mechanics from an equivalence principle

    Energy Technology Data Exchange (ETDEWEB)

    Faraggi, A.E. [Univ. of Florida, Gainesville, FL (United States). Inst. for Fundamental Theory; Matone, M. [Univ. of Padova (Italy)

    1997-05-15

    The authors show that requiring diffeomorphic equivalence for one-dimensional stationary states implies that the reduced action S{sub 0} satisfies the quantum Hamilton-Jacobi equation with the Planck constant playing the role of a covariantizing parameter. The construction shows the existence of a fundamental initial condition which is strictly related to the Moebius symmetry of the Legendre transform and to its involutive character. The universal nature of the initial condition implies the Schroedinger equation in any dimension.

  11. Derived equivalences induced by good silting complexes

    OpenAIRE

    Breaz, Simion; Modoi, George Ciprian

    2017-01-01

    Consider a (possibly big) silting object $U$ in a derived category over a (dg-)algebra $A$. Under some fairly general appropriate hypotheses, we show that it induces derived equivalences between the derived category over $A$ and a localization of the derived category of dg-endomorphism algebra $B$ of $U$. If, in addition, $U$ is small then this localization is the whole derived category over $B$.

  12. Global equivalent magnetization of the oceanic lithosphere

    Science.gov (United States)

    Dyment, J.; Choi, Y.; Hamoudi, M.; Lesur, V.; Thebault, E.

    2015-11-01

    As a by-product of the construction of a new World Digital Magnetic Anomaly Map over oceanic areas, we use an original approach based on the global forward modeling of seafloor spreading magnetic anomalies and their comparison to the available marine magnetic data to derive the first map of the equivalent magnetization over the World's ocean. This map reveals consistent patterns related to the age of the oceanic lithosphere, the spreading rate at which it was formed, and the presence of mantle thermal anomalies which affects seafloor spreading and the resulting lithosphere. As for the age, the equivalent magnetization decreases significantly during the first 10-15 Myr after its formation, probably due to the alteration of crustal magnetic minerals under pervasive hydrothermal alteration, then increases regularly between 20 and 70 Ma, reflecting variations in the field strength or source effects such as the acquisition of a secondary magnetization. As for the spreading rate, the equivalent magnetization is twice as strong in areas formed at fast rate than in those formed at slow rate, with a threshold at ∼40 km/Myr, in agreement with an independent global analysis of the amplitude of Anomaly 25. This result, combined with those from the study of the anomalous skewness of marine magnetic anomalies, allows building a unified model for the magnetic structure of normal oceanic lithosphere as a function of spreading rate. Finally, specific areas affected by thermal mantle anomalies at the time of their formation exhibit peculiar equivalent magnetization signatures, such as the cold Australian-Antarctic Discordance, marked by a lower magnetization, and several hotspots, marked by a high magnetization.

  13. APTE: An Algorithm for Proving Trace Equivalence

    OpenAIRE

    Cheval, Vincent

    2014-01-01

    This paper presents APTE, a new tool for automatically proving the security of cryptographic protocols. It focuses on proving trace equivalence between processes, which is crucial for specifying privacy type properties such as anonymity and unlinkability.\\ud \\ud The tool can handle protocols expressed in a calculus similar to the applied-pi calculus, which allows us to capture most existing protocols that rely on classical cryptographic primitives. In particular, APTE handles private channels...

  14. Two Tests for the Equivalence Principle

    Science.gov (United States)

    Harpaz, Amos

    2011-06-01

    The question: "Is the equivalence principle (EP) a general principle" is examined by analyzing solutions to two cases: 1. The Twin Paradox, and 2. Does a static charge located in a gravitational field radiate? The solutions to these two cases are given first by using EP, and then by physical analysis of the system involved. The fact that the two methods yield the same solutions, may be considered as test cases for the validity of the EP.

  15. Equivalent Lagrangians: Generalization, Transformation Maps, and Applications

    Directory of Open Access Journals (Sweden)

    N. Wilson

    2012-01-01

    Full Text Available Equivalent Lagrangians are used to find, via transformations, solutions and conservation laws of a given differential equation by exploiting the possible existence of an isomorphic algebra of Lie point symmetries and, more particularly, an isomorphic Noether point symmetry algebra. Applications include ordinary differential equations such as the Kummer equation and the combined gravity-inertial-Rossbywave equation and certain classes of partial differential equations related to multidimensional wave equations.

  16. Capacitors with low equivalent series resistance

    Science.gov (United States)

    Fleig, Patrick Franz (Inventor); Lakeman, Charles D. E. (Inventor); Fuge, Mark (Inventor)

    2011-01-01

    An electric double layer capacitor (EDLC) in a coin or button cell configuration having low equivalent series resistance (ESR). The capacitor comprises mesh or other porous metal that is attached via conducting adhesive to one or both the current collectors. The mesh is embedded into the surface of the adjacent electrode, thereby reducing the interfacial resistance between the electrode and the current collector, thus reducing the ESR of the capacitor.

  17. Determining sample size when assessing mean equivalence.

    Science.gov (United States)

    Asberg, Arne; Solem, Kristine B; Mikkelsen, Gustav

    2014-11-01

    When we want to assess whether two analytical methods are equivalent, we could test if the difference between the mean results is within the specification limits of 0 ± an acceptance criterion. Testing the null hypothesis of zero difference is less interesting, and so is the sample size estimation based on testing that hypothesis. Power function curves for equivalence testing experiments are not widely available. In this paper we present power function curves to help decide on the number of measurements when testing equivalence between the means of two analytical methods. Computer simulation was used to calculate the probability that the 90% confidence interval for the difference between the means of two analytical methods would exceed the specification limits of 0 ± 1, 0 ± 2 or 0 ± 3 analytical standard deviations (SDa), respectively. The probability of getting a nonequivalence alarm increases with increasing difference between the means when the difference is well within the specification limits. The probability increases with decreasing sample size and with smaller acceptance criteria. We may need at least 40-50 measurements with each analytical method when the specification limits are 0 ± 1 SDa, and 10-15 and 5-10 when the specification limits are 0 ± 2 and 0 ± 3 SDa, respectively. The power function curves provide information of the probability of false alarm, so that we can decide on the sample size under less uncertainty.

  18. Generic vancomycin products fail in vivo despite being pharmaceutical equivalents of the innovator.

    Science.gov (United States)

    Vesga, Omar; Agudelo, Maria; Salazar, Beatriz E; Rodriguez, Carlos A; Zuluaga, Andres F

    2010-08-01

    Generic versions of intravenous antibiotics are not required to demonstrate therapeutic equivalence with the innovator because therapeutic equivalence is assumed from pharmaceutical equivalence. To test such assumptions, we studied three generic versions of vancomycin in simultaneous experiments with the innovator and determined the concentration and potency of the active pharmaceutical ingredient by microbiological assay, single-dose pharmacokinetics in infected mice, antibacterial effect by broth microdilution and time-kill curves (TKC), and pharmacodynamics against two wild-type strains of Staphylococcus aureus by using the neutropenic mouse thigh infection model. The main outcome measure was the comparison of magnitudes and patterns of in vivo efficacy between generic products and the innovator. Except for one product exhibiting slightly greater concentration, vancomycin generics were undistinguishable from the innovator based on concentration and potency, protein binding, in vitro antibacterial effect determined by minimal inhibitory or bactericidal concentrations and TKC, and serum pharmacokinetics. Despite such similarities, all generic products failed in vivo to kill S. aureus, while the innovator displayed the expected bactericidal efficacy: maximum antibacterial effect (Emax) (95% confidence interval [CI]) was 2.04 (1.89 to 2.19), 2.59 (2.21 to 2.98), and 3.48 (2.92 to 4.04) versus 5.65 (5.52 to 5.78) log10 CFU/g for three generics and the innovator product, respectively (P<0.0001, any comparison). Nonlinear regression analysis suggests that generic versions of vancomycin contain inhibitory and stimulatory principles within their formulations that cause agonistic-antagonistic actions responsible for in vivo failure. In conclusion, pharmaceutical equivalence does not imply therapeutic equivalence for vancomycin.

  19. Generic Vancomycin Products Fail In Vivo despite Being Pharmaceutical Equivalents of the Innovator ▿

    Science.gov (United States)

    Vesga, Omar; Agudelo, Maria; Salazar, Beatriz E.; Rodriguez, Carlos A.; Zuluaga, Andres F.

    2010-01-01

    Generic versions of intravenous antibiotics are not required to demonstrate therapeutic equivalence with the innovator because therapeutic equivalence is assumed from pharmaceutical equivalence. To test such assumptions, we studied three generic versions of vancomycin in simultaneous experiments with the innovator and determined the concentration and potency of the active pharmaceutical ingredient by microbiological assay, single-dose pharmacokinetics in infected mice, antibacterial effect by broth microdilution and time-kill curves (TKC), and pharmacodynamics against two wild-type strains of Staphylococcus aureus by using the neutropenic mouse thigh infection model. The main outcome measure was the comparison of magnitudes and patterns of in vivo efficacy between generic products and the innovator. Except for one product exhibiting slightly greater concentration, vancomycin generics were undistinguishable from the innovator based on concentration and potency, protein binding, in vitro antibacterial effect determined by minimal inhibitory or bactericidal concentrations and TKC, and serum pharmacokinetics. Despite such similarities, all generic products failed in vivo to kill S. aureus, while the innovator displayed the expected bactericidal efficacy: maximum antibacterial effect (Emax) (95% confidence interval [CI]) was 2.04 (1.89 to 2.19), 2.59 (2.21 to 2.98), and 3.48 (2.92 to 4.04) versus 5.65 (5.52 to 5.78) log10 CFU/g for three generics and the innovator product, respectively (P < 0.0001, any comparison). Nonlinear regression analysis suggests that generic versions of vancomycin contain inhibitory and stimulatory principles within their formulations that cause agonistic-antagonistic actions responsible for in vivo failure. In conclusion, pharmaceutical equivalence does not imply therapeutic equivalence for vancomycin. PMID:20547818

  20. [Therapeutic possibilities after traumatic experiences].

    Science.gov (United States)

    Kapfhammer, Hans-Peter

    2008-12-01

    Acute stress disorder (ASD) and posttraumatic stress disorder (PTSD) are frequent, but not obligatory psychological sequelae following trauma. A major subgroup of patients face a chronic course of illness associated with an increased psychiatric comorbidity and significant impairments in psychosocial adaptation. The typical psychopathological symptoms of ASD and PTSD are best described within a multifactorial model integrating both neurobiological and psychosocial influences. The complex etiopathogenesis of acute and posttraumatic stress disorder favours multimodal approaches in the treatment. Differential psychotherapeutic and pharmacological strategies are available. In a critical survey on empirical studies, psychological debriefing cannot be considered as a positive approach to be recommended as general preventive measure during the immediate posttraumatic phase. Positive effects of cognitive-behavioral interventions can be established for ASD. Psychodynamic psychotherapy, cognitive-behavioral therapy and EMDR show promising results in the treatment of PTSD. Major clinical restrictions of patient sampling within special research facilities, however, do not allow an unconditional generalization of these data to psychiatric routine care. In an empirical analysis the SSRIs are the most and best studied medications for ASD and PTSD. In comparison to tricyclic antidepressants SSRIs demonstrate a broader spectrum of therapeutic effects and are better tolerated. The substance classes of SSNRI, DAS, SARI and NaSSA are to be considered as drugs of second choice. They promise a therapeutic efficacy equivalent to the SSRIs, being investigated so far only in open studies. MAO-inhibitors may dispose of a positive therapeutic potential, their profile of side effects must be respected, however. Mood stabilizers and atypical neuroleptics may be used first and foremost in add-on strategies. Benzodiazepines should be used only with increased caution for a short time in states of

  1. Therapeutic Climate Within a Treatment Program for Categorical Deniers.

    Science.gov (United States)

    Ware, Jayson

    2017-07-01

    The purpose of this study was to examine whether the therapeutic climate within a sex offender "deniers" program, where denial was not challenged, would be equivalent to the therapeutic climate within a conventional program where sex offenders were admitting responsibility. Using a sample of 77 sex offenders, therapeutic alliance and group climate were measured early and late in treatment. As expected, therapeutic alliance was more difficult to attain with deniers early in treatment, particularly therapeutic bond; however, by the end of the treatment, there were no significant differences in therapeutic alliance. There did not appear to be significant differences in group climate early or late in treatment except for the deniers reporting significantly lower levels of open expression of anger and disagreement within the group and, in contrast to the admitters, making significant improvements in group climate over time. Implications for the treatment of categorical deniers and further research suggestions are discussed.

  2. Equivalent Circuit Modeling of Hysteresis Motors

    Energy Technology Data Exchange (ETDEWEB)

    Nitao, J J; Scharlemann, E T; Kirkendall, B A

    2009-08-31

    We performed a literature review and found that many equivalent circuit models of hysteresis motors in use today are incorrect. The model by Miyairi and Kataoka (1965) is the correct one. We extended the model by transforming it to quadrature coordinates, amenable to circuit or digital simulation. 'Hunting' is an oscillatory phenomenon often observed in hysteresis motors. While several works have attempted to model the phenomenon with some partial success, we present a new complete model that predicts hunting from first principles.

  3. Real Options Valuation Based on Certainty Equivalents

    Directory of Open Access Journals (Sweden)

    Cecilia Maya Ochoa

    2014-12-01

    Full Text Available This purpose of this research is to identify appropriate rates to discount the flows from real options in situations in which the risk-free rate does not apply, in particular, in incomplete markets.  A methodology is proposed for valuing real options based on certainty equivalence, which requires as a principal condition the consideration of preferences represented with utility functions.  A constant relative risk aversion (CRRA utility function is used to represent these preferences. The results indicate that this methodology adequately reflects how the value of a real option changes in accordance with an investor´s preferences.

  4. Applicability constraints of the equivalence theorem

    Energy Technology Data Exchange (ETDEWEB)

    Dobado, A.; Pelaez, J.R. [Departamento de Fisica Teorica, Universidad Complutense, 28040 Madrid (Spain); Urdiales, M.T. [Departamento de Fisica Teorica, Universidad Autonoma, 28049 Madrid (Spain)

    1997-12-01

    In this work we study the applicability of the equivalence theorem, either for unitary models or within an effective Lagrangian approach. There are two types of limitations: the existence of a validity energy window and the use of the lowest order in the electroweak constants. For the first kind, we consider some methods, based on dispersion theory or the large N limit, that allow us to extend the applicability. For the second, we obtain numerical estimates of the effect of neglecting higher orders in the perturbative expansion. {copyright} {ital 1997} {ital The American Physical Society}

  5. Open maps, behavioural equivalences, and congruences

    DEFF Research Database (Denmark)

    Cheng, Allan; Nielsen, Mogens

    1996-01-01

    Spans of open maps have been proposed by Joyal, Nielsen, and Winskel as a way of adjoining an abstract equivalence, P-bisimilarity, to a category of models of computation M, where P is an arbitrary sub-category of observations. Part of the motivation was to recast and generalise Milner's well...... viewed as functors preserve P-bisimilarity? We define the notion of functors being P -factorisable, show how this ensures that P-bisimilarity is a congruence with respect to such functors. Guided by the definition of P-factorisability we show how it is possible to parametrise proofs of functors being P...

  6. Galilean equivalence for galactic dark matter.

    Science.gov (United States)

    Kesden, Michael; Kamionkowski, Marc

    2006-09-29

    Satellite galaxies are tidally disrupted as they orbit the Milky Way. If dark matter (DM) experiences a stronger self-attraction than baryons, stars will preferentially gain rather than lose energy during tidal disruption, leading to an enhancement in the trailing compared to the leading tidal stream. The Sgr dwarf galaxy is seen to have roughly equal streams, challenging models in which DM and baryons accelerate differently by more than 10%. Future observations and a better understanding of DM distribution should allow detection of equivalence violation at the percent level.

  7. Equivalent Circuit for Magnetoelectric Read and Write

    OpenAIRE

    Camsari, Kerem Y.; Faria, Rafatul; Hassan, Orchi; Sutton, Brian M.; Datta, Supriyo

    2017-01-01

    We describe an equivalent circuit model applicable to a wide variety of magnetoelectric phenomena and use SPICE simulations to benchmark this model against experimental data. We use this model to suggest a different mode of operation where the "1" and "0'" states are not represented by states with net magnetization (like $m_x$, $m_y$ or $m_z$) but by different easy axes, quantitatively described by ($m_x^2 - m_y^2$) which switches from "0" to "1" through the write voltage. This change is dire...

  8. European Equivalencies in Legal Interpreting and Translation

    DEFF Research Database (Denmark)

    Corsellis, Ann; Hertog, Erik; Martinsen, Bodil

    2002-01-01

    Within Europe there is increasing freedom of movement between countries and increasing inward migration. As a result, equivalent standards of legl interpreting and translation are required to allow reliable communication for judicial cooperation between member states, for criminal and civil matters...... which cross national borders and for the needs of multilingual populations. The European Convention of Human Rights (article 6, paragrph 3) is one of the main planks of relevant legislation. This international, two year project has been funded by the EU Grotius programme to set out what is required...

  9. Therapeutic use exemption

    Science.gov (United States)

    Dvorak, J; Kirkendall, D; Vouillamoz, M

    2006-01-01

    Football players who have either physical symptoms or disease after injury may need to be treated with specific medicines that are on the list of prohibited substances. Therapeutic use exemption may be granted to such players, in accordance with strictly defined criteria—these are presented in this article. Procedures of how to request for an abbreviated or a standard therapeutic use exemption are explained, and data on therapeutic use exemptions (UEFA and FIFA, 2004 and 2005) are also presented. PMID:16799102

  10. Integrable topological billiards and equivalent dynamical systems

    Science.gov (United States)

    Vedyushkina, V. V.; Fomenko, A. T.

    2017-08-01

    We consider several topological integrable billiards and prove that they are Liouville equivalent to many systems of rigid body dynamics. The proof uses the Fomenko-Zieschang theory of invariants of integrable systems. We study billiards bounded by arcs of confocal quadrics and their generalizations, generalized billiards, where the motion occurs on a locally planar surface obtained by gluing several planar domains isometrically along their boundaries, which are arcs of confocal quadrics. We describe two new classes of integrable billiards bounded by arcs of confocal quadrics, namely, non-compact billiards and generalized billiards obtained by gluing planar billiards along non-convex parts of their boundaries. We completely classify non-compact billiards bounded by arcs of confocal quadrics and study their topology using the Fomenko invariants that describe the bifurcations of singular leaves of the additional integral. We study the topology of isoenergy surfaces for some non-convex generalized billiards. It turns out that they possess exotic Liouville foliations: the integral trajectories of the billiard that lie on some singular leaves admit no continuous extension. Such billiards appear to be leafwise equivalent to billiards bounded by arcs of confocal quadrics in the Minkowski metric.

  11. Equivalent Relaxations of Optimal Power Flow

    Energy Technology Data Exchange (ETDEWEB)

    Bose, S; Low, SH; Teeraratkul, T; Hassibi, B

    2015-03-01

    Several convex relaxations of the optimal power flow (OPF) problem have recently been developed using both bus injection models and branch flow models. In this paper, we prove relations among three convex relaxations: a semidefinite relaxation that computes a full matrix, a chordal relaxation based on a chordal extension of the network graph, and a second-order cone relaxation that computes the smallest partial matrix. We prove a bijection between the feasible sets of the OPF in the bus injection model and the branch flow model, establishing the equivalence of these two models and their second-order cone relaxations. Our results imply that, for radial networks, all these relaxations are equivalent and one should always solve the second-order cone relaxation. For mesh networks, the semidefinite relaxation and the chordal relaxation are equally tight and both are strictly tighter than the second-order cone relaxation. Therefore, for mesh networks, one should either solve the chordal relaxation or the SOCP relaxation, trading off tightness and the required computational effort. Simulations are used to illustrate these results.

  12. Free fall and the equivalence principle revisited

    Science.gov (United States)

    Pendrill, Ann-Marie

    2017-11-01

    Free fall is commonly discussed as an example of the equivalence principle, in the context of a homogeneous gravitational field, which is a reasonable approximation for small test masses falling moderate distances. Newton’s law of gravity provides a generalisation to larger distances, and also brings in an inhomogeneity in the gravitational field. In addition, Newton’s third law of action and reaction causes the Earth to accelerate towards the falling object, bringing in a mass dependence in the time required for an object to reach ground—in spite of the equivalence between inertial and gravitational mass. These aspects are rarely discussed in textbooks when the motion of everyday objects are discussed. Although these effects are extremely small, it may still be important for teachers to make assumptions and approximations explicit, to be aware of small corrections, and also to be prepared to estimate their size. Even if the corrections are not part of regular teaching, some students may reflect on them, and their questions deserve to be taken seriously.

  13. Fiber-coupled Luminescence Dosimetry in Therapeutic and Diagnostic Radiology

    DEFF Research Database (Denmark)

    Andersen, Claus Erik

    2011-01-01

    Fiber-coupled luminescence dosimetry is an emerging technology with several potentially attractive features of relevance for uses in therapeutic and diagnostic radiology: direct water equivalence (i.e. no significant perturbation of the radiation field in a water phantom or a patient), sub...

  14. Chicanoizing the Therapeutic Community

    Science.gov (United States)

    Aron, William S.; And Others

    1974-01-01

    Focusing on the drug addiction problem and its antecedent conditions in a Chicano population, the article examines several therapeutic interventions suggested by these conditions and indicates how they might be incorporated into a drug addiction Therapeutic Community treatment program designed to meet the needs of Chicano drug addicts. (Author/NQ)

  15. Therapeutic Crisis Intervention.

    Science.gov (United States)

    Holden, Martha J.; Powers, Jane Levine

    1993-01-01

    Describes Therapeutic Crisis Intervention (TCI) program as providing staff with skills, knowledge, and confidence to manage child in crisis to bring about a "maximum amount of lasting response." Contends that, by applying principles of TCI training, direct care worker can attain therapeutic control and maintain dignity of both adult and child…

  16. Trends in Therapeutic Recreation.

    Science.gov (United States)

    Smith, Ralph W.

    1995-01-01

    Discusses the implications of the rapid, dramatic changes taking place in therapeutic recreation for individuals with physical disabilities. The article notes the impact of changes in managed care, examines programming trends in therapeutic recreation (adventure/outdoor education, competitive sports, handcycling, health enhancement activities, and…

  17. Premetric equivalent of general relativity: Teleparallelism

    Science.gov (United States)

    Itin, Yakov; Hehl, Friedrich W.; Obukhov, Yuri N.

    2017-04-01

    In general relativity (GR), the metric tensor of spacetime is essential since it represents the gravitational potential. In other gauge theories (such as electromagnetism), the so-called premetric approach succeeds in separating the purely topological field equation from the metric-dependent constitutive law. We show here that GR allows for a premetric formulation, too. For this purpose, we apply the teleparallel approach of gravity, which represents GR as a gauge theory based on the translation group. We formulate the metric-free topological field equation and a general linear constitutive law between the basic field variables. The requirement of local Lorentz invariance turns the model into a full equivalent of GR. Our approach opens a way for a natural extension of GR to diverse geometrical structures of spacetime.

  18. Characterization of Destrins with Different Dextrose Equivalents

    Directory of Open Access Journals (Sweden)

    Guanglei Li

    2010-07-01

    Full Text Available Dextrins are widely used for their functional properties and prepared by partial hydrolysis of starch using acid, enzymes, or combinations of both. The physiochemical properties of dextrins are dependent on their molecular distribution and oligosaccharide profiles. In this study, scanning electron microscopy (SEM, X-ray diffractometry (XRD, rapid viscoanalysis (RVA, high-performance Liquid Chromatography (HPLC and gel permeation chromatography (GPC were used to characterize dextrins prepared by common neutral and thermostable α-amylase hydrolysis. The dextrin granules displayed irregular surfaces and were badly damaged by the enzyme treatment. They displayed A-type X-ray diffraction patterns with a decrease of intensity of the characteristic diffraction peaks. The RVA profiles showed that the viscosity of dextrin decreased with the increase of its Dextrose Equivalent (DE value. According to HPLC analysis, the molecular weight, degree of polymerization and the composition of oligosaccharides in dextrins were different.

  19. Expressivism, Relativism and the analytic equivalence test

    Directory of Open Access Journals (Sweden)

    Maria J. Frapolli

    2015-11-01

    Full Text Available The purpose of this paper is to show that, pace (Field 2009, 252, MacFarlane’s assessment relativism and expressivism should be sharply distinguished. We do so by arguing that relativism and expressivism exemplify two very different approaches to context-dependence. Relativism, on the one hand, shares with other contemporary approaches a bottom-up, building block, model, while expressivism is part of a different tradition, one that might include Lewis’ epistemic contextualism and Frege’s content individuation, with which it shares an organic model to deal with context-dependence. The building-block model and the organic model, and thus relativism and expressivism, are set apart with the aid of a particular test: only the building-block model is compatible with the idea that there might be analytically equivalent, and yet different, propositions.

  20. Expressivism, Relativism, and the Analytic Equivalence Test.

    Science.gov (United States)

    Frápolli, Maria J; Villanueva, Neftalí

    2015-01-01

    The purpose of this paper is to show that, pace (Field, 2009), MacFarlane's assessment relativism and expressivism should be sharply distinguished. We do so by arguing that relativism and expressivism exemplify two very different approaches to context-dependence. Relativism, on the one hand, shares with other contemporary approaches a bottom-up, building block, model, while expressivism is part of a different tradition, one that might include Lewis' epistemic contextualism and Frege's content individuation, with which it shares an organic model to deal with context-dependence. The building-block model and the organic model, and thus relativism and expressivism, are set apart with the aid of a particular test: only the building-block model is compatible with the idea that there might be analytically equivalent, and yet different, propositions.

  1. Theoretical Aspects of the Equivalence Principle

    CERN Document Server

    Damour, Thibault

    2012-01-01

    We review several theoretical aspects of the Equivalence Principle (EP). We emphasize the unsatisfactory fact that the EP maintains the absolute character of the coupling constants of physics while General Relativity, and its generalizations (Kaluza-Klein,..., String Theory), suggest that all absolute structures should be replaced by dynamical entities. We discuss the EP-violation phenomenology of dilaton-like models, which is likely to be dominated by the linear superposition of two effects: a signal proportional to the nuclear Coulomb energy, related to the variation of the fine-structure constant, and a signal proportional to the surface nuclear binding energy, related to the variation of the light quark masses. We recall the various theoretical arguments (including a recently proposed anthropic argument) suggesting that the EP be violated at a small, but not unmeasurably small level. This motivates the need for improved tests of the EP. These tests are probing new territories in physics that are related t...

  2. Framework for Application of the Toxicity Equivalence ...

    Science.gov (United States)

    Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) are persistent contaminants found widely in the environment. Several of these compounds bioaccumulate in the tissues of fish, birds, and mammals and have been shown to cause mortality and adverse effects on reproduction, development, and the immune system. EPA has developed a framework intended to assist Agency scientists in using a method known as the toxicity equivalence methodology to evaluate the ecological risks of these chemicals. The methodology offers a means to derive a single exposure estimate from multiple chemical concentrations found in environmental mixtures so that risk assessors can consider their cumulative impacts. This framework helps to clarify this methodology’s strengths, limitations, and role within the broader context of ecological risk assessment.

  3. Reporting therapeutic discourse in a therapeutic community.

    Science.gov (United States)

    Chapman, G E

    1988-03-01

    Research in nurses' communications has concentrated on nurse to patient interactions. Those few studies which focus on nurse to nurse communications seem to be generated by a pragmatic and normative concern with effective information sharing. In this paper, which describes one aspect of a larger case study of a hospital-based therapeutic community, the description and analysis of nurses' reports flows not from a normative model of professional practice, but rather an exploration of how professional practice is articulated as discourse in nurses' written accounts. Foucault's ideas about therapeutic discourse inform the theoretical framework of the research. Ethnomethodological concerns with the importance of documentary analysis provide the methodological rationale for examining nurses' 24-hour report documents, as official discourse, reflecting therapeutic practice in this setting. A content analysis of nurses' reports, collected over a period of 4 months, demonstrated the importance of domesticity and ordinary everyday activities in nurses' accounts of hospital life. Disruption to the 'life as usual' domesticity in the community seemed to be associated with admission to and discharge from the hospital when interpersonal and interactional changes between patients occur. It is suggested that nurses in general hospital wards and more orthodox psychiatric settings might usefully consider the impact of admissions and discharges on the group of patients they manage, and make this a discursive focus of their work.

  4. Auditory Stimulus Equivalence and Non-Arbitrary Relations

    National Research Council Canada - National Science Library

    Stewart, Ian; Lavelle, Niamh

    2013-01-01

    This study extended previous research on stimulus equivalence with all auditory stimuli by using a methodology more similar to conventional match-to-sample training and testing for three 3-member equivalence relations...

  5. 49 CFR 391.33 - Equivalent of road test.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Equivalent of road test. 391.33 Section 391.33... AND LONGER COMBINATION VEHICLE (LCV) DRIVER INSTRUCTORS Tests § 391.33 Equivalent of road test. (a) In place of, and as equivalent to, the road test required by § 391.31, a person who seeks to drive a...

  6. Approaches to the treatment of zero equivalence in a bilingual ...

    African Journals Online (AJOL)

    The absence of equivalents in the TL is marked by two symbols: Ø (a complete absence of any equivalent) and # (equivalence at the level of the entire message rather than at word level). Sixty-five lemmata in the ESD contain a slashed zero, a hash or both, but one and the same entry can contain more than one symbol.

  7. Development of a tissue-engineered human oral mucosa equivalent based on an acellular allogeneic dermal matrix: a preliminary report of clinical application to burn wounds.

    Science.gov (United States)

    Iida, Takuya; Takami, Yoshihiro; Yamaguchi, Ryo; Shimazaki, Shuji; Harii, Kiyonori

    2005-01-01

    Tissue-engineered skin equivalents composed of epidermal and dermal components have been widely investigated for coverage of full-thickness skin defects. We developed a tissue-engineered oral mucosa equivalent based on an acellular allogeneic dermal matrix and investigated its characteristics. We also tried and assessed its preliminary clinical application. Human oral mucosal keratinocytes were separated from a piece of oral mucosa and cultured in a chemically-defined medium. The keratinocytes were seeded on to the acellular allogeneic dermal matrix and cultured. Histologically, the mucosa equivalent had a well-stratified epithelial layer. Immunohistochemical study showed that it was similar to normal oral mucosa. We applied this equivalent in one case with an extensive burn wound. The equivalent was transplanted three weeks after the harvest of the patient's oral mucosa and about 30% of the graft finally survived. We conclude that this new oral mucosa equivalent could become a therapeutic option for the treatment of extensive burns.

  8. Tests of the weak equivalence principle

    Science.gov (United States)

    Speake, C. C.; Will, C. M.

    2012-09-01

    The Einstein equivalence principle is the foundation for general relativity and all metric theories of gravity. Of its three tenets—the equality of acceleration of test bodies, or weak equivalence principle; the validity of Lorentz invariance in local freely falling frames; and the position invariance of local physical laws—the weak equivalence principle has played the most important role historically, and continues to be a focus of intense theoretical and experimental investigation. From the probably apocryphal 16th century demonstrations by Galileo at Pisa's leaning tower to the sensitive torsion-balance measurements of today (both pictured on the cover of this issue), this principle, dubbed WEP, has been crucial to the development of gravitation theory. The universality of the rate of acceleration of all types of matter in a gravitational field can be taken as evidence that gravitation is fundamentally determined by the geometry, or metric, of spacetime. Newton began his magnum opus 'The Principia' with a discussion of WEP and his experiments to verify it, while Einstein took WEP for granted in his construction of general relativity, never once referring to the epochal experiments by Baron Eötvös. The classic 1964 experiment of Roll, Krotkov and Dicke ushered in the modern era of high-precision tests, and the search for a 'fifth force' during the late 1980s (instigated, ironically, by purported anomalies in Eötvös's old data) caused the enterprise to pivot from pure tests of the foundation of GR to searches for new physics beyond the standard model of the non-gravitational interactions. Today, the next generation of experimental tests of WEP are being prepared for launch or are being developed, with the goal of reaching unprecedented levels of sensitivity, in search of signatures of interactions inspired by string theory, extra dimensions and other concepts from the world of high-energy physics. At the same time observations continue using lunar laser

  9. [PLURAL THERAPEUTIC ITINERARIES].

    Science.gov (United States)

    Iorio, Silvia

    2015-01-01

    This article addresses the strategies employed by Nahua community of Mexixo to deal with health problems. Drawing on qualitative research, it discusses the choice of plural therapeutic itineraries, including the use of informal and formal healthcare.

  10. Notes on The Energy Equivalence of Information.

    Science.gov (United States)

    Matta, Chérif F; Massa, Lou

    2017-11-30

    Maxwell's demon makes observations and thereby collects information. As Brillouin points out such information is the negative of entropy (negentropy) and is the equivalent of a cost in energy. The energy cost of information can be quantified in the relationship E = kT ln 2, where k is the Boltzmann constant, T is the absolute temperature, and the factor ln 2 arises from the existence of two possibilities for a "yes/no" circumstance, as, for example, in the passage of a proton through a barrier controlled by a Maxwell's demon. This paper considers further conclusions that follow from the quantification of the energy cost of information. First, consideration of the minimum uncertainty in the measurement of energy cost of information leads to an expression for the uncertainty in the corresponding time of the measurement, which depends inversely upon temperature at which the measurements occur. Second, because of the universal connection between energy and mass, an almost imperceptible mass accompanies the accumulation of information. And third, to account for the total free energy change that describes the action of adenosine triphosphate (ATP) synthase, an additional term is suggested to be appended to the Mitchell chemiosmotic equation, which describes this process. The additional term accounts for the energy cost of sorting away from background ions those protons allowed to enter the ATP synthase.

  11. Testing the equivalence principle on a trampoline

    Science.gov (United States)

    Reasenberg, Robert D.; Phillips, James D.

    2001-07-01

    We are developing a Galilean test of the equivalence principle in which two pairs of test mass assemblies (TMA) are in free fall in a comoving vacuum chamber for about 0.9 s. The TMA are tossed upward, and the process repeats at 1.2 s intervals. Each TMA carries a solid quartz retroreflector and a payload mass of about one-third of the total TMA mass. The relative vertical motion of the TMA of each pair is monitored by a laser gauge working in an optical cavity formed by the retroreflectors. Single-toss precision of the relative acceleration of a single pair of TMA is 3.5×10-12 g. The project goal of Δg/g = 10-13 can be reached in a single night's run, but repetition with altered configurations will be required to ensure the correction of systematic error to the nominal accuracy level. Because the measurements can be made quickly, we plan to study several pairs of materials.

  12. Challenging a culture of racial equivalence.

    Science.gov (United States)

    Song, Miri

    2014-03-01

    We live at a time when our understandings and conceptualizations of 'racism' are often highly imprecise, broad, and used to describe a wide range of racialized phenomena. In this article, I raise some important questions about how the term racism is used and understood in contemporary British society by drawing on some recent cases of alleged racism in football and politics, many of which have been played out via new media technologies. A broader understanding of racism, through the use of the term 'racialization', has been helpful in articulating a more nuanced and complex understanding of racial incidents, especially of people's (often ambivalent) beliefs and behaviours. However, the growing emphasis upon 'racialization' has led to a conceptualization of racism which increasingly involves multiple perpetrators, victims, and practices without enough consideration of how and why particular interactions and practices constitute racism as such. The trend toward a growing culture of racial equivalence is worrying, as it denudes the idea of racism of its historical basis, severity and power. These frequent and commonplace assertions of racism in the public sphere paradoxically end up trivializing and homogenizing quite different forms of racialized interactions. I conclude that we need to retain the term 'racism', but we need to differentiate more clearly between 'racism' (as an historical and structured system of domination) from the broader notion of 'racialization'. © London School of Economics and Political Science 2014.

  13. Mathematical Equivalence of Evolution and Design

    Directory of Open Access Journals (Sweden)

    Leonid Perlovsky

    2010-12-01

    Full Text Available "Every one who is seriously involved in the pursuit of science becomes convinced that a spirit is manifest in the laws of the Universe." This Einsteinian statement remains outside of science. Our current understanding of the mind mechanisms have come close to explaining spirituality from the scientific point of view. In this paper a theory is presented which is a mathematical breakthrough, overcoming decades of limitations in AI, pattern recognition, neural networks, and other attempts to model the brain-mind. Solutions to engineering problems are presented that have overcome previous difficulties in terms of computational complexity. These solutions result in orders of magnitude improvement in detection, prediction, tracking, fusion, and learning situations. The theory is also extended to higher cognitive functions. It models the knowledge instinct operating in the hierarchy of the human brain-mind. At the top are concepts unifying our entire knowledge; we perceive them as concepts of the meaning and purpose of our existence. This theory is formulated mathematically as dynamic and equivalently as teleological. Experimental results supporting the theory are discussed. The theory overcomes various difficulties, including reductionism, which, in the past, interfered with the acceptance of scientific explanations of the spiritual.

  14. On the Equivalence of HLLE and LTSA.

    Science.gov (United States)

    Zhang, Sumin; Ma, Zhengming; Tan, Hengliang

    2018-02-01

    Among the representative algorithms of manifold learning, Hessian locally linear embedding (HLLE) and local tangent space alignment (LTSA) algorithms haven been regarded as two different algorithms. However, in practice, the effects of these two algorithms are very similar and LTSA performs better than HLLE in some applications. This paper tries to account for this phenomenon from a mathematical point of view. There are only two differences between HLLE and LTSA. First, LTSA includes a data point into its neighborhood, while HLLE does not. Second, HLLE and LTSA use different methods to align the local coordinates of manifold. In this paper, we show that, the first difference between HLLE and LTSA is not essential. However, from the viewpoint of data utilization, LTSA does better than HLLE in the neighborhood construction. This may account for why LTSA can perform better than HLLE in some applications. As for the second difference between HLLE and LTSA, we first prove that, the alignment equations used by HLLE and LTSA are exactly the same. Second, we prove that, although HLLE and LTSA uses different methods to solve the alignment equation, their solutions are exactly the same, provided that HLLE adopts the same method as LTSA to construct the neighborhoods. Based on these arguments, we claim that HLLE and LTSA are equivalent to each other. This conclusion can also be verified experimentally by using manifold learning MATLAB demo (MANI), a widely-used experimental platform of manifold learning. When testing HLLE on MANI, if HLLE adopts the same method as LTSA to construct the neighborhoods, the experimental results presented by MANI will be the same as those of LTSA.

  15. General Dynamic Equivalent Modeling of Microgrid Based on Physical Background

    Directory of Open Access Journals (Sweden)

    Changchun Cai

    2015-11-01

    Full Text Available Microgrid is a new power system concept consisting of small-scale distributed energy resources; storage devices and loads. It is necessary to employ a simplified model of microgrid in the simulation of a distribution network integrating large-scale microgrids. Based on the detailed model of the components, an equivalent model of microgrid is proposed in this paper. The equivalent model comprises two parts: namely, equivalent machine component and equivalent static component. Equivalent machine component describes the dynamics of synchronous generator, asynchronous wind turbine and induction motor, equivalent static component describes the dynamics of photovoltaic, storage and static load. The trajectory sensitivities of the equivalent model parameters with respect to the output variables are analyzed. The key parameters that play important roles in the dynamics of the output variables of the equivalent model are identified and included in further parameter estimation. Particle Swarm Optimization (PSO is improved for the parameter estimation of the equivalent model. Simulations are performed in different microgrid operation conditions to evaluate the effectiveness of the equivalent model of microgrid.

  16. Kant and therapeutic privilege.

    Science.gov (United States)

    Brown, Chris

    2008-08-01

    Given Kant's exceptionless moral prohibition on lying, one might suspect that he is committed to a similar prohibition on withholding diagnostic and prognostic information from patients. I confirm this suspicion by adapting arguments against therapeutic privilege from his arguments against lying. However, I show that all these arguments are importantly flawed and submit that they should be rejected. A more compelling Kantian take on informed consent and therapeutic privilege is achievable, I argue, by focusing on Kant's duty of beneficence, which requires us to aim at furthering others' ends. But I show that there are some cases in which furthering a patient's ends requires withholding material medical information from her. Although I concede that these cases are probably quite rare, I conclude that the best Kantian thinking agrees with that of therapeutic privilege's advocates.

  17. Lymphedema and Therapeutic Lymphangiogenesis

    Directory of Open Access Journals (Sweden)

    Yukihiro Saito

    2013-01-01

    Full Text Available Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are limited. Although rarely lethal, lymphedema is a disfiguring and disabling condition with an associated decrease in the quality of life. The recent impressive expansion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities for the treatment of lymphedema. This review highlights the lymphatic biology, the pathophysiology of lymphedema, and the therapeutic lymphangiogenesis using hepatocyte growth factor.

  18. Therapeutic development in psoriasis.

    Science.gov (United States)

    Sobell, Jeffrey M; Leonardi, Craig L

    2014-06-01

    Advances in molecular biology have provided the basis for development of new therapeutic approaches to psoriasis. New, more effective therapies target specific molecules in the inflammatory cascade involved in the pathogenesis of psoriasis.The biologic era of psoriasis therapy began with inhibitors of T-cell activation, tumor necrosis factor-α, and interleukin (IL)-12/23. Continued investigation has led to therapies and therapeutic candidates that target IL-17, IL-23, phosphodiesterase-4, and isomers of Janus kinase. 2014 by Frontline Medical Communications Inc.

  19. Therapeutic HIV Peptide Vaccine

    DEFF Research Database (Denmark)

    Fomsgaard, Anders

    2015-01-01

    Therapeutic vaccines aim to control chronic HIV infection and eliminate the need for lifelong antiretroviral therapy (ART). Therapeutic HIV vaccine is being pursued as part of a functional cure for HIV/AIDS. We have outlined a basic protocol for inducing new T cell immunity during chronic HIV-1...... infection directed to subdominant conserved HIV-1 epitopes restricted to frequent HLA supertypes. The rationale for selecting HIV peptides and adjuvants are provided. Peptide subunit vaccines are regarded as safe due to the simplicity, quality, purity, and low toxicity. The caveat is reduced immunogenicity...

  20. Dynamic equivalence relation on the fuzzy measure algebras

    Directory of Open Access Journals (Sweden)

    Roya Ghasemkhani

    2017-04-01

    Full Text Available The main goal of the present paper is to extend classical results from the measure theory and dynamical systems to the fuzzy subset setting. In this paper, the notion of  dynamic equivalence relation is introduced and then it is proved that this relation is an equivalence relation. Also, a new metric on the collection of all equivalence classes is introduced and it is proved that this metric is complete.

  1. Equivalent Viscous Damping Models in Displacement Based Seismic Design

    Directory of Open Access Journals (Sweden)

    Raul Zaharia

    2005-01-01

    Full Text Available The paper reviews some equivalent viscous damping models used in the displacement based seismic design considering the equivalent linearization. The limits of application of the models are highlighted, based on comparison existing in the literature. The study is part of research developed by author, aimed to determine the equivalent linear parameters in order to predict the maximum displacement response for earthquakes compatible with given response spectra.

  2. Equivalence of Deterministic Nested Word to Word Transducers

    Science.gov (United States)

    Staworko, Sławomir; Laurence, Grégoire; Lemay, Aurélien; Niehren, Joachim

    We study the equivalence problem of deterministic nested word to word transducers and show it to be surprisingly robust. Modulo polynomial time reductions, it can be identified with 4 equivalence problems for diverse classes of deterministic non-copying order-preserving transducers. In particular, we present polynomial time back and fourth reductions to the morphism equivalence problem on context free languages, which is known to be solvable in polynomial time.

  3. Approximate Testing Equivalence Based on Time, Probability, and Observed Behavior

    Directory of Open Access Journals (Sweden)

    Alessandro Aldini

    2010-06-01

    Full Text Available Several application domains require formal but flexible approaches to the comparison problem. Different process models that cannot be related by behavioral equivalences should be compared via a quantitative notion of similarity, which is usually achieved through approximation of some equivalence. While in the literature the classical equivalence subject to approximation is bisimulation, in this paper we propose a novel approach based on testing equivalence. As a step towards flexibility and usability, we study different relaxations taking into account orthogonal aspects of the process observations: execution time, event probability, and observed behavior. In this unifying framework, both interpretation of the measures and decidability of the verification algorithms are discussed.

  4. Therapeutic Recombinant Monoclonal Antibodies

    Science.gov (United States)

    Bakhtiar, Ray

    2012-01-01

    During the last two decades, the rapid growth of biotechnology-derived techniques has led to a myriad of therapeutic recombinant monoclonal antibodies with significant clinical benefits. Recombinant monoclonal antibodies can be obtained from a number of natural sources such as animal cell cultures using recombinant DNA engineering. In contrast to…

  5. Therapeutic HPV DNA vaccines

    Science.gov (United States)

    Lin, Ken; Roosinovich, Elena; Ma, Barbara; Hung, Chien-Fu

    2010-01-01

    It is now well established that most cervical cancers are causally associated with HPV infection. This realization has led to efforts to control HPV-associated malignancy through prevention or treatment of HPV infection. Currently, commercially available HPV vaccines are not designed to control established HPV infection and associated premalignant and malignant lesions. To treat and eradicate pre-existing HPV infections and associated lesions which remain prevalent in the U.S. and worldwide, effective therapeutic HPV vaccines are needed. DNA vaccination has emerged as a particularly promising form of therapeutic HPV vaccines due to its safety, stability and ability to induce antigen-specific immunity. This review focuses on improving the potency of therapeutic HPV vaccines through modification of dendritic cells (DCs) by [1] increasing the number of antigen-expressing/antigen-loaded DCs, [2] improving HPV antigen expression, processing and presentation in DCs, and [3] enhancing DC and T cell interaction. Continued improvement in therapeutic HPV DNA vaccines may ultimately lead to an effective DNA vaccine for the treatment of HPV-associated malignancies. PMID:20066511

  6. Methodological questions of creating tissue-equivalent phantoms

    Science.gov (United States)

    Kolodkin, A. V.; Popov, V. I.; Sychkov, M. A.; Nikl, I.; Erdei, M.; Eyben, O.

    1974-01-01

    On the basis of analysis and generalization of literature data, the composition of tissue equivalent plastic was justified, parameters of a standard man were determined, plaster and metal forms were created for casting dummies, and an experimental model was produced from tissue equivalent material.

  7. On the equivalence of brushlet and wavelet bases

    DEFF Research Database (Denmark)

    Nielsen, Morten; Borup, Lasse

    2005-01-01

    We prove that the Meyer wavelet basis and a class of brushlet systems associated with exponential type partitions of the frequency axis form a family of equivalent (unconditional) bases for the Besov and Triebel-Lizorkin function spaces. This equivalence is then used to obtain new results...

  8. On the equivalence of brushlet and wavelet bases

    DEFF Research Database (Denmark)

    Borup, Lasse; Nielsen, Morten

    We prove that the Meyer wavelet basis and a class of brushlet systems associated with exponential type partitions of the frequency axis form a family of equivalent (unconditional) bases for the Besov and Triebel-Lizorkin function spaces. This equivalence is then used to obtain new results...

  9. 40 CFR 133.105 - Treatment equivalent to secondary treatment.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Treatment equivalent to secondary treatment. 133.105 Section 133.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS SECONDARY TREATMENT REGULATION § 133.105 Treatment equivalent to secondary treatment...

  10. When is a background equivalent? Sparse chromatic context revisited

    NARCIS (Netherlands)

    Brenner, E; Cornelissen, FW

    Jenness and Shevell (Vision Res 1995,35:797-805) reported that a red background with white dots scattered on it has a different influence on a target's apparent colour than an equivalent uniform background. We show that this finding depends on what one considers an equivalent background. Jenness and

  11. Students' Conceptions of Models of Fractions and Equivalence

    Science.gov (United States)

    Jigyel, Karma; Afamasaga-Fuata'i, Karoline

    2007-01-01

    A solid understanding of equivalent fractions is considered a steppingstone towards a better understanding of operations with fractions. In this article, 55 rural Australian students' conceptions of equivalent fractions are presented. Data collected included students' responses to a short written test and follow-up interviews with three students…

  12. An equivalent problem to the Twin Prime Conjecture

    OpenAIRE

    Balestrieri, F.

    2011-01-01

    In this short paper we will show, via elementary arguments, the equivalence of the Twin Prime Conjecture to a problem which might be simpler to prove. Some conclusions are drawn, and it is shown that proving the Twin Prime Conjecture is equivalent to proving that there cannot be an infinite string of consecutive natural numbers satisfying some specified equations.

  13. Unitary equivalence classes of one-dimensional quantum walks II

    Science.gov (United States)

    Ohno, Hiromichi

    2017-12-01

    This study investigated the unitary equivalence classes of one-dimensional quantum walks with and without initial states. We determined the unitary equivalence classes of one-dimensional quantum walks, two-phase quantum walks with one defect, complete two-phase quantum walks, one-dimensional quantum walks with one defect and translation-invariant one-dimensional quantum walks.

  14. Theoretical equivalence in classical mechanics and its relationship to duality

    Science.gov (United States)

    Teh, Nicholas J.; Tsementzis, Dimitris

    2017-08-01

    As a prolegomenon to understanding the sense in which dualities are theoretical equivalences, we investigate the intuitive 'equivalence' of hyper-regular Lagrangian and Hamiltonian classical mechanics. We show that the symplectification of these theories (via Tulczyjew's Triple) provides a sense in which they are (1) isomorphic, and (2) mutually and canonically definable through an analog of 'common definitional extension'.

  15. Assessment Battery for Communication: Development of Two Equivalent Forms

    Science.gov (United States)

    Bosco, Francesca M.; Angeleri, Romina; Zuffranieri, Marco; Bara, Bruno G.; Sacco, Katiuscia

    2012-01-01

    The aim of this paper was to develop and test two equivalent forms of the Assessment Battery for Communication (ABaCo), a tool for evaluating pragmatic abilities in patients with neuropsychological and psychiatric disorders. The equivalent forms were created using the data from a sample of 390 children, then tested in a sample of 30 patients with…

  16. Basis for equivalent fluence concept in space solar cells

    Science.gov (United States)

    Meulenberg, A.

    1982-01-01

    The equivalent fluence concept is defined, and its use and potential problems are noted. Silicon and GaAs solar cells are compared in a radiation environment. The analysis indicates that valid equivalent fluence values may be easier to obtain in GaAs than in silicon.

  17. 49 CFR 538.8 - Gallon Equivalents for Gaseous Fuels.

    Science.gov (United States)

    2010-10-01

    ... VEHICLES § 538.8 Gallon Equivalents for Gaseous Fuels. The gallon equivalent of gaseous fuels, for purposes... Natural Gas 0.823 Liquefied Natural Gas 0.823 Liquefied Petroleum Gas (Grade HD-5)* 0.726 Hydrogen 0.259...

  18. Physicochemical equivalence of some brands of Nifedipine retard ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-02-22

    Feb 22, 2010 ... Full Length Research Paper. Physicochemical equivalence of some brands of ... Nigeria. Accepted 9 November, 2009. This research evaluated the physicochemical equivalence of some samples of Nifedipine 20 mg Retard ... Tel: +23408052742521. dicarboxylate. It is light sensitive and its photo-reaction.

  19. On the equivalence of two fundamental theta identities

    NARCIS (Netherlands)

    Koornwinder, T.H.

    2014-01-01

    Two fundamental theta identities, a three-term identity due to Weierstrass and a five-term identity due to Jacobi, both with products of four theta functions as terms, are shown to be equivalent. One half of the equivalence was already proved by R. J. Chapman in 1996. The history and usage of the

  20. Estimation of U.S. Timber Harvest Using Roundwood Equivalents

    Science.gov (United States)

    James Howard

    2006-01-01

    This report details the procedure used to estimate the roundwood products portion of U.S. annual timber harvest levels by using roundwood equivalents. National-level U.S. forest products data published by trade associations and State and Federal Government organizations were used to estimate the roundwood equivalent of national roundwood products production. The...

  1. Mechanical Equivalent of Heat--Software for a Thermistor

    Science.gov (United States)

    Boleman, Michael

    2008-01-01

    The Mechanical Equivalent of Heat Apparatus from PASCO scientific provides the means for doing a simple experiment to determine the mechanical equivalent of heat, "J." A necessary step of this experiment is to determine the temperature of an aluminum cylinder. By measuring the resistance of a thermistor embedded in the cylinder, one is able to…

  2. Inter Digital Transducer Modelling through Mason Equivalent Circuit Model

    DEFF Research Database (Denmark)

    Mishra, Dipti; Singh, Abhishek; Hussain, Dil muhammed Akbar

    2016-01-01

    The frequency reliance of inter-digital transducer is analyzed with the help of MASON’s Equivalent circuit which is based on Smith’s Equivalent circuit which is further based on Foster’sNetwork. An inter-digital transducer has been demonstratedas a RLC network. The circuit is simulated by Simulat......The frequency reliance of inter-digital transducer is analyzed with the help of MASON’s Equivalent circuit which is based on Smith’s Equivalent circuit which is further based on Foster’sNetwork. An inter-digital transducer has been demonstratedas a RLC network. The circuit is simulated...... by Simulation program with Integrated Circuit Emphasis (HSPICE), a well-liked electronic path simulator. The acoustic wave devices are not suitable to simulation through circuit simulator.In this paper, an electrical model of Mason’s Equivalent electricalcircuit for an inter-digital transducer (IDT...

  3. Inter digital transducer modelling through Mason equivalent circuit model

    DEFF Research Database (Denmark)

    Mishra, Dipti; Singh, Abhishek; Hussain, Dil muhammed Akbar

    2016-01-01

    The frequency reliance of inter-digital transducer is analyzed with the help of MASON's Equivalent circuit which is based on Smith's Equivalent circuit which is further based on Foster's Network. An inter-digital transducer has been demonstrated as a RLC network. The circuit is simulated by Simul......The frequency reliance of inter-digital transducer is analyzed with the help of MASON's Equivalent circuit which is based on Smith's Equivalent circuit which is further based on Foster's Network. An inter-digital transducer has been demonstrated as a RLC network. The circuit is simulated...... by Simulation program with Integrated Circuit Emphasis (HSPICE), a well-liked electronic path simulator. The acoustic wave devices are not suitable to simulation through circuit simulator. In this paper, an electrical model of Mason's Equivalent electrical circuit for an inter-digital transducer (IDT...

  4. Multistage vector (MSV) therapeutics

    Science.gov (United States)

    Wolfram, Joy; Shen, Haifa; Ferrari, Mauro

    2015-01-01

    One of the greatest challenges in the field of medicine is obtaining controlled distribution of systemically administered therapeutic agents within the body. Indeed, biological barriers such as physical compartmentalization, pressure gradients, and excretion pathways adversely affect localized delivery of drugs to pathological tissue. The diverse nature of these barriers requires the use of multifunctional drug delivery vehicles that can overcome a wide range of sequential obstacles. In this review, we explore the role of multifunctionality in nanomedicine by primarily focusing on multistage vectors (MSVs). The MSV is an example of a promising therapeutic platform that incorporates several components, including a microparticle, nanoparticles, and small molecules. In particular, these components are activated in a sequential manner in order to successively address transport barriers. PMID:26264836

  5. Acylation of Therapeutic Peptides

    DEFF Research Database (Denmark)

    Trier, Sofie; Henriksen, Jonas Rosager; Jensen, Simon Bjerregaard

    Oral administration of therapeutic peptides could benefit millions of chronically ill people worldwide, through easier and less stigmatized therapy, and likely improve the long-term effects of currently widespread disease mismanagement. However, oral peptide delivery is a formidable task due......, but it is not widely studied in an oral context. As acylation furthermore increases interactions with the lipid membranes of mammalian cells, it offers several potential benefits for oral delivery of therapeutic peptides, and we hypothesize that tailoring the acylation may be used to optimize intestinal translocation...... to the harsh and selective gastrointestinal system, and development has lacked far behind injection therapy. Peptide acylation is a powerful tool to alter the pharmacokinetics, biophysical properties and chemical stability of injectable peptide drugs, primarily used to prolong blood circulation...

  6. Therapeutic use of cannabis.

    Science.gov (United States)

    de Vries, Kay; Green, Anita J

    Therapeutic cannabis use raises a number of dilemmas for nurses. This article examines the legal, political and ethical challenges raised by the use of cannabis by people with life-limiting or terminal illnesses in their own homes. (Throughout this paper, the term cannabis refers to illegal cannabis unless specified.) A literature review of databases from 1996 was conducted and internet material was also examined. Evidence on the therapeutic use of cannabis suggests it may produce improvements in quality of life, which has led to increased use among people with life-limiting illnesses. The cannabis used is usually obtained illegally, which can have consequences for both those who use it and nurses who provide treatment in the community.

  7. On identifying name equivalences in digital libraries. Name equivalence, Surname matching, Author identification, Databases

    Directory of Open Access Journals (Sweden)

    Dror G. Feitelson

    2004-01-01

    Full Text Available The services provided by digital libraries can be much improved by correctly identifying variants of the same name. For example, this will allow for better retrieval of all the works by a certain author. We focus on variants caused by abbreviations of first names, and show that significant achievements are possible by simple lexical analysis and comparison of names. This is done in two steps: first a pairwise matching of names is performed, and then these are used to find cliques of equivalent names. However, these steps can each be performed in a variety of ways. We therefore conduct an experimental analysis using two real datasets to find which approaches actually work well in practice. Interestingly, this depends on the size of the repository, as larger repositories may have many more similar names.

  8. Leech Therapeutic Applications

    OpenAIRE

    Abdualkader, A. M.; A M Ghawi; Alaama, M.; M. Awang; A Merzouk

    2013-01-01

    Hematophagous animals including leeches have been known to possess biologically active compounds in their secretions, especially in their saliva. The blood-sucking annelids, leeches have been used for therapeutic purposes since the beginning of civilization. Ancient Egyptian, Indian, Greek and Arab physicians used leeches for a wide range of diseases starting from the conventional use for bleeding to systemic ailments, such as skin diseases, nervous system abnormalities, urinary and reproduct...

  9. Therapeutic communication in nursing students: A Walker & Avant concept analysis.

    Science.gov (United States)

    Abdolrahimi, Mahbobeh; Ghiyasvandian, Shahrzad; Zakerimoghadam, Masoumeh; Ebadi, Abbas

    2017-08-01

    Therapeutic communication, the fundamental component of nursing, is a complex concept. Furthermore, the poor encounters between nursing student and patient demonstrate the necessity of instruction regarding therapeutic communication. The aim of this study was to define and clarify this important concept for including this subject in the nursing curriculum with more emphasis. A literature search was conducted using keywords such as "nursing student", "patient" and "therapeutic communication" and Persian-equivalent words in Persian databases (including Magiran and Medlib) and English databases (including PubMed, ScienceDirect, Scopus and ProQuest) without time limitation. After extracting concept definitions and determining characteristic features, therapeutic communication in nursing students was defined. Then, sample cases, antecedents, consequences and empirical referents of concept were determined. After assessing 30 articles, therapeutic communication defining attributes were as follows: "an important means in building interpersonal relationships", "a process of information transmission", "an important clinical competency", "a structure with two different sections" and "a significant tool in patient centered care". Furthermore, theoretical and clinical education and receiving educators' feedback regarding therapeutic communication were considered as antecedents of the concept. Improving physical and psychological health status of patient as well as professional development of nursing students were identified as consequences of the concept. Nursing instructors can use these results in order to teach and evaluate therapeutic communication in nursing students and train qualified nurses. Also, nursing students may apply the results to improve the quality of their interactions with patients, perform their various duties and meet patients' diverse needs.

  10. Nine Equivalents of Nursing Manpower Use Score (NEMS: um estudo de seu processo histórico Nine Equivalents of Nursing Manpower Use Score (NEMS: un estudio de su proceso histórico Nine Equivalents of Nursing Manpower Use Score (NEMS: a study of its historical process

    Directory of Open Access Journals (Sweden)

    Simone Travi Canabarro

    2010-09-01

    Full Text Available Este estudo visa, por meio de uma revisão integrativa da literatura, descrever o percurso histórico dos escores de intervenções terapêuticas com ênfase no Nine Equivalents of Nursing Manpower Use Score (NEMS em Unidade de Terapia Intensiva. Foram utilizados os descritores "Unidades de terapia intensiva" e "escalas" para publicações entre 2000 e 2009. Foram selecionados "Nine Equivalents of Nursing Manpower Use Score" ou "NEMS", "Unidade de Terapia Intensiva", "Therapeutic Intervention Scoring System-76", "Therapeutic Intervention Scoring System-28 ou "TISS-28". Selecionaram-se publicações das bases Medical Literature Analysis and Retrieval System Online (MEDLINE e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS. Dos 295 artigos capturados, 18 foram incluídos, sendo 55,5% em inglês. Os estudos abordam o NEMS (33,3%, Therapeutic Intervention Scoring System-76 (11,1%, TISS-28 (33,3%, entre outros. Pesquisas destacaram que o NEMS vem demonstrando ser uma ferramenta útil, operacional e sucinta.Este estudio tiene el objetivo de, através de una revisión integradora de la literatura, describir el recorrido histórico de los puntajes de intervenciones terapéuticas con énfasis en el Nine Equivalents of Nursing Manpower Use Score (NEMS, en Unidades de Cuidados Intensivos. Se utilizaron los descriptores "Unidades de terapia intensiva" y escalas" para publicaciones entre 2000 y 2009. Han sido seleccionados "Nine Equivalents of Nursing Manpower Use Score" o "NEMS", "Unidade de Terapia Intensiva", "Therapeutic Intervention Scoring System-76", "Therapeutic Intervention Scoring System-28 o "TISS-28". Se seleccionaron publicaciones de las bases Medical Literature Analysis and Retrieval System Online (MEDLINE y Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS. De los 295 artículos elegidos se incluyeron 18, entre los cuales 55,5% en inglés. Los estudios enfocaron el NEMS (33,3%, Therapeutic

  11. Spaces of homotopy self-equivalences a survey

    CERN Document Server

    Rutter, John W

    1997-01-01

    This survey covers groups of homotopy self-equivalence classes of topological spaces, and the homotopy type of spaces of homotopy self-equivalences. For manifolds, the full group of equivalences and the mapping class group are compared, as are the corresponding spaces. Included are methods of calculation, numerous calculations, finite generation results, Whitehead torsion and other areas. Some 330 references are given. The book assumes familiarity with cell complexes, homology and homotopy. Graduate students and established researchers can use it for learning, for reference, and to determine the current state of knowledge.

  12. Theory of Covariance Equivalent ARMAV Models of Civil Engineering Structures

    DEFF Research Database (Denmark)

    Andersen, P.; Brincker, Rune; Kirkegaard, Poul Henning

    1996-01-01

    In this paper the theoretical background for using covariance equivalent ARMAV models in modal analysis is discussed. It is shown how to obtain a covariance equivalent ARMA model for a univariate linear second order continous-time system excited by Gaussian white noise. This result is generalized...... for multi-variate systems to an ARMAV model. The covariance equivalent model structure is also considered when the number of channels are different from the number of degrees offreedom to be modelled. Finally, it is reviewed how to estimate an ARMAV model from sampled data....

  13. Theory of Covariance Equivalent ARMAV Models of Civil Engineering Structures

    DEFF Research Database (Denmark)

    Andersen, P.; Brincker, Rune; Kirkegaard, Poul Henning

    In this paper the theoretical background for using covariance equivalent ARMAV models in modal analysis is discussed. It is shown how to obtain a covariance equivalent ARMA model for a univariate linear second order continuous-time system excited by Gaussian white noise. This result is generalized...... for multivariate systems to an ARMAV model. The covariance equivalent model structure is also considered when the number of channels are different from the number of degrees of freedom to be modelled. Finally, it is reviewed how to estimate an ARMAV model from sampled data....

  14. Frankincense--therapeutic properties.

    Science.gov (United States)

    Al-Yasiry, Ali Ridha Mustafa; Kiczorowska, Bożena

    2016-01-04

    Recently, increasing interest in natural dietary and therapeutic preparations used as dietary supplements has been observed. One of them is frankincense. This traditional medicine of the East is believed to have anti-inflammatory, expectorant, antiseptic, and even anxiolytic and anti-neurotic effects. The present study aims to verify the reported therapeutic properties of Boswellia resin and describe its chemical composition based on available scientific studies. The main component of frankincense is oil (60%). It contains mono- (13%) and diterpenes (40%) as well as ethyl acetate (21.4%), octyl acetate (13.4%) and methylanisole (7.6%). The highest biological activity among terpenes is characteristic of 11-keto-ß-acetyl-beta-boswellic acid, acetyl-11-keto-ß-boswellic acid and acetyl-α-boswellic acid. Contemporary studies have shown that resin indeed has an analgesic, tranquilising and anti-bacterial effects. From the point of view of therapeutic properties, extracts from Boswellia serrata and Boswellia carterii are reported to be particularly useful. They reduce inflammatory conditions in the course of rheumatism by inhibiting leukocyte elastase and degrading glycosaminoglycans. Boswellia preparations inhibit 5-lipoxygenase and prevent the release of leukotrienes, thus having an anti-inflammatory effect in ulcerative colitis, irritable bowel syndrome, bronchitis and sinusitis. Inhalation and consumption of Boswellia olibanum reduces the risk of asthma. In addition, boswellic acids have an antiproliferative effect on tumours. They inhibit proliferation of tumour cells of the leukaemia and glioblastoma subset. They have an anti-tumour effect since they inhibit topoisomerase I and II-alpha and stimulate programmed cell death (apoptosis).

  15. Frankincense – therapeutic properties

    Directory of Open Access Journals (Sweden)

    Ali Ridha Mustafa Al-Yasiry

    2016-01-01

    Full Text Available Recently, increasing interest in natural dietary and therapeutic preparations used as dietary supplements has been observed. One of them is frankincense. This traditional medicine of the East is believed to have anti-inflammatory, expectorant, antiseptic, and even anxiolytic and anti-neurotic effects. The present study aims to verify the reported therapeutic properties of Boswellia resin and describe its chemical composition based on available scientific studies. The main component of frankincense is oil (60%. It contains mono- (13% and diterpenes (40% as well as ethyl acetate (21.4%, octyl acetate (13.4% and methylanisole (7.6%. The highest biological activity among terpenes is characteristic of 11-keto-ß-acetyl-beta-boswellic acid, acetyl-11-keto-ß-boswellic acid and acetyl-α-boswellic acid. Contemporary studies have shown that resin indeed has an analgesic, tranquilising and anti-bacterial effects. From the point of view of therapeutic properties, extracts from Boswellia serrata and Boswellia carterii are reported to be particularly useful. They reduce inflammatory conditions in the course of rheumatism by inhibiting leukocyte elastase and degrading glycosaminoglycans. Boswellia preparations inhibit 5-lipoxygenase and prevent the release of leukotrienes, thus having an anti-inflammatory effect in ulcerative colitis, irritable bowel syndrome, bronchitis and sinusitis. Inhalation and consumption of Boswellia olibanum reduces the risk of asthma. In addition, boswellic acids have an antiproliferative effect on tumours. They inhibit proliferation of tumour cells of the leukaemia and glioblastoma subset. They have an anti-tumour effect since they inhibit topoisomerase I and II-alpha and stimulate programmed cell death (apoptosis.

  16. [Therapeutic applications of digestive endoscopy].

    Science.gov (United States)

    Ortega, J A; Pérez, L; Madureri, V

    1976-01-01

    Endoscopy has proven useful as a diagnostic tool and recently many useful therapeutic possibilities have been proposed. The authors discuss their experience with therapeutic endoscopic procedures and present new ones for treatment of Acalasia and small sliding hiatal hernia.

  17. Therapeutic approaches to cellulite.

    Science.gov (United States)

    Green, Jeremy B; Cohen, Joel L; Kaufman, Joely; Metelitsa, Andrei I; Kaminer, Michael S

    2015-09-01

    Cellulite is a condition that affects the vast majority of women. Although it is of no danger to one's overall health, cellulite can be psychosocially debilitating. Consequently, much research has been devoted to understanding cellulite and its etiopathogenesis. With additional insights into the underlying causes of its clinical presentation, therapeutic modalities have been developed that offer hope to cellulite sufferers. This review examines evidence for topical treatments, noninvasive energy-based devices, and recently developed minimally invasive interventions that may finally provide a solution. ©2015 Frontline Medical Communications.

  18. [Achievement of therapeutic objectives].

    Science.gov (United States)

    Mantilla, Teresa

    2014-07-01

    Therapeutic objectives for patients with atherogenic dyslipidemia are achieved by improving patient compliance and adherence. Clinical practice guidelines address the importance of treatment compliance for achieving objectives. The combination of a fixed dose of pravastatin and fenofibrate increases the adherence by simplifying the drug regimen and reducing the number of daily doses. The good tolerance, the cost of the combination and the possibility of adjusting the administration to the patient's lifestyle helps achieve the objectives for these patients with high cardiovascular risk. Copyright © 2014 Sociedad Española de Arteriosclerosis y Elsevier España, S.L. All rights reserved.

  19. [Is therapeutic deadlock inevitable?].

    Science.gov (United States)

    Vignat, Jean-Pierre

    2016-01-01

    Many long-term treatments appear to be an expression of therapeutic deadlock. The situation leads to a questioning of the concept of chronicity and the identification of the determining factors of situations which are apparently blocked, marked by the search for solutions taking a back seat to the taking of action. The interaction between patients' mental apparatus and the care apparatus lies at the heart of the question, interpreted from an institutional, collective and individual perspective, supported by the clinical and psychopathological approach, and the return to the prioritisation of the thought. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  20. Guidelines for the communication of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop.

    Science.gov (United States)

    LaKind, Judy S; Aylward, Lesa L; Brunk, Conrad; DiZio, Stephen; Dourson, Michael; Goldstein, Daniel A; Kilpatrick, Michael E; Krewski, Daniel; Bartels, Michael J; Barton, Hugh A; Boogaard, Peter J; Lipscomb, John; Krishnan, Kannan; Nordberg, Monica; Okino, Miles; Tan, Yu-Mei; Viau, Claude; Yager, Janice W; Hays, Sean M

    2008-08-01

    Biomonitoring Equivalents (BEs) are screening tools for interpreting biomonitoring data. However, the development of BEs brings to the public a relatively novel concept in the field of health risk assessment and presents new challenges for environmental risk communication. This paper provides guidance on methods for conveying information to the general public, the health care community, regulators and other interested parties regarding how chemical-specific BEs are derived, what they mean in terms of health, and the challenges and questions related to interpretation and communication of biomonitoring data. Key communication issues include: (i) developing a definition of the BE that accurately captures the BE concept in lay terms, (ii) how to compare population biomonitoring data to BEs, (iii) interpreting biomonitoring data that exceed BEs for a specific chemical, (iv) how to best describe the confidence in chemical-specific BEs, and (v) key requirements for effective communication with health care professionals. While the risk communication literature specific to biomonitoring is sparse, many of the concepts developed for traditional risk assessments apply, including transparency and discussions of confidence and uncertainty. Communication of BEs will require outreach, education, and development of communication materials specific to several audiences including the lay public and health care providers.

  1. Mechanisms of Plasma Therapeutics

    Science.gov (United States)

    Graves, David

    2015-09-01

    In this talk, I address research directed towards biomedical applications of atmospheric pressure plasma such as sterilization, surgery, wound healing and anti-cancer therapy. The field has seen remarkable growth in the last 3-5 years, but the mechanisms responsible for the biomedical effects have remained mysterious. It is known that plasmas readily create reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS (or RONS), in addition to a suite of other radical and non-radical reactive species, are essential actors in an important sub-field of aerobic biology termed ``redox'' (or oxidation-reduction) biology. It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue in part by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated RONS. RONS-exposed surface layers of cells communicate to the deeper levels of tissue via a form of the ``bystander effect,'' similar to responses to other forms of cell stress. In this proposed model of CAP therapeutics, the plasma stimulates a cellular survival mechanism through which aerobic organisms shield themselves from infection and other challenges.

  2. Therapeutic Uses of Exosomes

    Directory of Open Access Journals (Sweden)

    Zacharias E. Suntres

    2013-01-01

    Full Text Available Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many cell types into the extracellular milieu. Exosomes are found in cell culture supernatants and in different biological fluids and are known to be secreted by most cell types under normal and pathological conditions. Considerable research is focusing on the exploitation of exosomes in biological fluids for biomarkers in the diagnosis of disease. More recently, exosomes are being exploited for their therapeutic potential. Exosomes derived from dendritic cells, tumor cells, and malignant effusions demonstrate immunomodulatory functions and are able to present antigens to T-cells and stimulate antigen-specific T-cell responses. Exosomes have also been examined for their therapeutic potential in the treatment of infections such as toxoplasmosis, diphtheria, tuberculosis and atypical severe acute respiratory syndrome as well as autoimmune diseases. Attempts to find practical applications for exosomes continue to expand with the role of exosomes as a drug delivery system for the treatment of autoimmune/inflammatory diseases and cancers.

  3. Engineering therapeutic protein disaggregases.

    Science.gov (United States)

    Shorter, James

    2016-05-15

    Therapeutic agents are urgently required to cure several common and fatal neurodegenerative disorders caused by protein misfolding and aggregation, including amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD). Protein disaggregases that reverse protein misfolding and restore proteins to native structure, function, and localization could mitigate neurodegeneration by simultaneously reversing 1) any toxic gain of function of the misfolded form and 2) any loss of function due to misfolding. Potentiated variants of Hsp104, a hexameric AAA+ ATPase and protein disaggregase from yeast, have been engineered to robustly disaggregate misfolded proteins connected with ALS (e.g., TDP-43 and FUS) and PD (e.g., α-synuclein). However, Hsp104 has no metazoan homologue. Metazoa possess protein disaggregase systems distinct from Hsp104, including Hsp110, Hsp70, and Hsp40, as well as HtrA1, which might be harnessed to reverse deleterious protein misfolding. Nevertheless, vicissitudes of aging, environment, or genetics conspire to negate these disaggregase systems in neurodegenerative disease. Thus, engineering potentiated human protein disaggregases or isolating small-molecule enhancers of their activity could yield transformative therapeutics for ALS, PD, and AD. © 2016 Shorter. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  4. Affine equivalence of cubic homogeneous rotation symmetric Boolean functions

    CERN Document Server

    Cusick, Thomas W

    2010-01-01

    Homogeneous rotation symmetric Boolean functions have been extensively studied in recent years because of their applications in cryptography. Little is known about the basic question of when two such functions are affine equivalent. The simplest case of quadratic rotation symmetric functions which are generated by cyclic permutations of the variables in a single monomial was only settled in 2009. This paper studies the much more complicated cubic case for such functions. A new concept of \\emph{patterns} is introduced, by means of which the structure of the smallest group G_n, whose action on the set of all such cubic functions in $n$ variables gives the affine equivalence classes for these functions under permutation of the variables, is determined. We conjecture that the equivalence classes are the same if all nonsingular affine transformations, not just permutations, are allowed. This conjecture is verified if n < 22. Our method gives much more information about the equivalence classes; for example, in t...

  5. Analysis of equivalent antenna based on FDTD method

    Directory of Open Access Journals (Sweden)

    Yun-xing Yang

    2014-09-01

    Full Text Available An equivalent microstrip antenna used in radio proximity fuse is presented. The design of this antenna is based on multilayer multi-permittivity dielectric substrate which is analyzed by finite difference time domain (FDTD method. Equivalent iterative formula is modified in the condition of cylindrical coordinate system. The mixed substrate which contains two kinds of media (one of them is airtakes the place of original single substrate. The results of equivalent antenna simulation show that the resonant frequency of equivalent antenna is similar to that of the original antenna. The validity of analysis can be validated by means of antenna resonant frequency formula. Two antennas have same radiation pattern and similar gain. This method can be used to reduce the weight of antenna, which is significant to the design of missile-borne antenna.

  6. Equivalence principle and quantum mechanics: quantum simulation with entangled photons

    Science.gov (United States)

    Longhi, S.

    2018-01-01

    Einstein`s equivalence principle states the complete physical equivalence of a gravitational field and corresponding inertial field in an accelerated reference frame. However, to what extent the equivalence principle remains valid in non-relativistic quantum mechanics is a controversial issue. To avoid violation of the equivalence principle, Bargmann`s superselection rule forbids a coherent superposition of states with different masses. Here we suggest a quantum simulation of non-relativistic Schr\\"odinger particle dynamics in non-inertial reference frames, which is based on propagation of polarization-entangled photon pairs in curved and birefringent optical waveguides and Hong-Ou-Mandel quantum interference measurement. The photonic simulator can emulate superposition of mass states, which would lead to violation of the EP.

  7. Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

    Science.gov (United States)

    Wang, Haining; Dai, Xi-Jie; Li, Chao-Jun

    2017-04-01

    Nucleophilic addition reactions of organometallic reagents to carbonyl compounds for carbon-carbon bond construction have played a pivotal role in modern chemistry. However, this reaction's reliance on petroleum-derived chemical feedstocks and a stoichiometric quantity of metal have prompted the development of many carbanion equivalents and catalytic metal alternatives. Here, we show that naturally occurring carbonyls can be used as latent alkyl carbanion equivalents for additions to carbonyl compounds, via reductive polarity reversal. Such 'umpolung' reactivity is facilitated by a ruthenium catalyst and diphosphine ligand under mild conditions, delivering synthetically valuable secondary and tertiary alcohols in up to 98% yield. The unique chemoselectivity exhibited by carbonyl-derived carbanion equivalents is demonstrated by their tolerance to protic reaction media and good functional group compatibility. Enantioenriched tertiary alcohols can also be accessed with the aid of chiral ligands, albeit with moderate stereocontrol. Such carbonyl-derived carbanion equivalents are anticipated to find broad utility in chemical bond formation.

  8. ESA GlobSnow Snow Water Equivalent (SWE)

    Data.gov (United States)

    National Aeronautics and Space Administration — The European Space Agency (ESA) Global Snow Monitoring for Climate Research (GlobSnow) snow water equivalent (SWE) v2.0 data record contains snow information derived...

  9. Problems of Equivalence in Shona- English Bilingual Dictionaries

    African Journals Online (AJOL)

    rbr

    translation equivalents in Shona-English dictionaries where lexicographers will be dealing with divergent languages and cultures, traditional practices of lexicography and the absence of reliable corpora. Keywords: BILINGUAL LEXICOGRAPHY, CORPUS, CULTURE, CULTURE-BOUND,. CULTURAL GAP, DICTIONARY ...

  10. On conjugate points and the Leitmann equivalent problem approach

    NARCIS (Netherlands)

    Wagener, F.O.O.

    2010-01-01

    This article extends the Leitmann equivalence method to a class of problems featuring conjugate points. The class is characterised by the requirement that the set of indifference points of a given problem forms a finite stratification.

  11. Influence of Gravitation on Mass-Energy Equivalence Relation

    OpenAIRE

    Pandya, R. V. R.

    2005-01-01

    We study influence of gravitational field on the mass-energy equivalence relation by incorporating gravitation in the physical situation considered by Einstein (Ann. Physik, 17, 1905, English translation in ref. [1]) for his first derivation of mass-energy equivalence. In doing so, we also refine Einstein's expression (Ann. Physik, 35, 1911, English translation in ref. [3]) for increase in gravitational mass of the body when it absorbs E amount of radiation energy.

  12. Human skin equivalent as an alternative to animal testing

    OpenAIRE

    Mertsching, Heike; Weimer, Michaela; Kersen, Silke; Brunner, Herwig

    2008-01-01

    The 3-D skin equivalent can be viewed as physiologically comparable to the natural skin and therefore is a suitable alternative for animal testing. This highly differentiated in vitro human skin equivalent is used to assess the efficacy and mode of action of novel agents. This model is generated from primary human keratinocytes on a collagen substrate containing human dermal fibroblasts. It is grown at the air-liquid interface which allows full epidermal stratification and epidermal-dermal in...

  13. Equivalence Between Out-of-Sample Forecast Comparisons and Wald

    DEFF Research Database (Denmark)

    Hansen, Peter Reinhard; Timmermann, Allan

    We establish the equivalence between a commonly used out-of-sample test of equal predictive accuracy and the difference between two Wald statistics. This equivalence greatly simplifies the computational burden of calculating recursive out-of-sample tests and evaluating their critical values. Our r...... results shed new light on many aspects of the test and establishes certain weaknesses associated with using out-of-sample forecast comparison tests to conduct inference about nested regression models....

  14. Noise equivalent circuit of a semiconductor laser diode

    OpenAIRE

    Harder, Christoph; Katz, Joseph; Margalit, S.; Shacham, J.; Yariv, A.

    1982-01-01

    The noise equivalent circuit of a semiconductor laser diode is derived from the rate equations including Langevin noise sources. This equivalent circuit allows a straightforward calculation of the noise and modulation characteristics of a laser diode combined with electronic components. The intrinsic junction voltage noise spectrum and the light intensity fluctuation of a current driven laser diode are calculated as a function of bias current and frequency.

  15. Equivalence of Quantum Resource Measures for X States

    Science.gov (United States)

    Huang, Zhiming; Zhang, Cai; Zhang, Wei; Zhao, Lianghui

    2017-11-01

    In this paper, we investigate some X states, quantum resource measures of which are equivalent. We find that for a class of X states, trace norm geometric quantum discord (TGQD), trace norm measurement-induced nonlocality (TMIN) and l 1 norm quantum coherence (L1QC) are all equal, and for some special states, therein two measures are equal. We also exemplify relative application of the equivalent relations.

  16. Dose Equivalents for Antipsychotic Drugs: The DDD Method.

    Science.gov (United States)

    Leucht, Stefan; Samara, Myrto; Heres, Stephan; Davis, John M

    2016-07-01

    Dose equivalents of antipsychotics are an important but difficult to define concept, because all methods have weaknesses and strongholds. We calculated dose equivalents based on defined daily doses (DDDs) presented by the World Health Organisation's Collaborative Center for Drug Statistics Methodology. Doses equivalent to 1mg olanzapine, 1mg risperidone, 1mg haloperidol, and 100mg chlorpromazine were presented and compared with the results of 3 other methods to define dose equivalence (the "minimum effective dose method," the "classical mean dose method," and an international consensus statement). We presented dose equivalents for 57 first-generation and second-generation antipsychotic drugs, available as oral, parenteral, or depot formulations. Overall, the identified equivalent doses were comparable with those of the other methods, but there were also outliers. The major strength of this method to define dose response is that DDDs are available for most drugs, including old antipsychotics, that they are based on a variety of sources, and that DDDs are an internationally accepted measure. The major limitations are that the information used to estimate DDDS is likely to differ between the drugs. Moreover, this information is not publicly available, so that it cannot be reviewed. The WHO stresses that DDDs are mainly a standardized measure of drug consumption, and their use as a measure of dose equivalence can therefore be misleading. We, therefore, recommend that if alternative, more "scientific" dose equivalence methods are available for a drug they should be preferred to DDDs. Moreover, our summary can be a useful resource for pharmacovigilance studies. © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  17. Steganographic Capacity of Images, based on Image Equivalence Classes

    DEFF Research Database (Denmark)

    Hansen, Klaus; Hammer, Christian; Andersen, Jens Damgaard

    2001-01-01

    The problem of hiding information imperceptibly can be formulated as the problem of determining if a given image is a member of a sufficiently large equivalence class of images which to the Human Visual System appears to be the same image. This makes it possible to replace the given image...... with a modified image similar in appearance but carrying imperceptibly coded information. This paper presents a framework and an experimental algorithm to estimate upper bounds for the size of an equivalence class....

  18. On the Equivalence of Euler-Lagrange and Noether Equations

    Energy Technology Data Exchange (ETDEWEB)

    Faliagas, A. C., E-mail: apostol.faliagas@gmail.com [University of Athens, Department of Mathematics (Greece)

    2016-03-15

    We prove that, under the condition of nontriviality, the Euler-Lagrange and Noether equations are equivalent for a general class of scalar variational problems. Examples are position independent Lagrangians, Lagrangians of p-Laplacian type, and Lagrangians leading to nonlinear Poisson equations. As applications we prove certain propositions concerning the nonlinear Poisson equation and its generalisations, and the equivalence of admissible and inner variations for the systems under consideration.

  19. Neutral theory and the evolution of ecological equivalence.

    Science.gov (United States)

    Hubbell, Stephen P

    2006-06-01

    Since the publication of the unified neutral theory in 2001, there has been much discussion of the theory, pro and con. The hypothesis of ecological equivalence is the fundamental yet controversial idea behind neutral theory. Assuming trophically similar species are demographically alike (symmetric) on a per capita basis is only an approximation, but it is equivalent to asking: How many of the patterns of ecological communities are the result of species similarities, rather than of species differences? The strategy behind neutral theory is to see how far one can get with the simplification of assuming ecological equivalence before introducing more complexity. In another paper, I review the empirical evidence that led me to hypothesize ecological equivalence among many of the tree species in the species-rich tropical forest on Barro Colorado Island (BCI). In this paper, I develop a simple model for the evolution of ecological equivalence or niche convergence, using as an example evolution of the suite of life history traits characteristic of shade tolerant tropical tree species. Although the model is simple, the conclusions from it seem likely to be robust. I conclude that ecological equivalence for resource use are likely to evolve easily and often, especially in species-rich communities that are dispersal and recruitment limited. In the case of the BCI forest, tree species are strongly dispersal- and recruitment-limited, not only because of restricted seed dispersal, but also because of low recruitment success due to heavy losses of the seedling stages to predators and pathogens and other abiotic stresses such as drought. These factors and the high species richness of the community strongly reduce the potential for competitive exclusion of functionally equivalent or nearly equivalent species.

  20. Mesoscale symmetries explain dynamical equivalence of food webs

    OpenAIRE

    Aufderheide, Helge; Rudolf, Lars; Gross, Thilo

    2012-01-01

    A present challenge in complex systems is to identify mesoscale structures that have distinct dynamical implications. In this paper we present a detailed investigation of a previously observed dynamical equivalence of certian ecological food webs. We show that this equivalence is rooted in mesoscale symmetries that exist in these webs. Certain eigenvectors of the Jacobian describing dynamical modes of the system, such as specific instabilities or responses to perturbations, localize on these ...

  1. Feedback equivalence of convolutional codes over finite rings

    Directory of Open Access Journals (Sweden)

    DeCastro-García Noemí

    2017-12-01

    Full Text Available The approach to convolutional codes from the linear systems point of view provides us with effective tools in order to construct convolutional codes with adequate properties that let us use them in many applications. In this work, we have generalized feedback equivalence between families of convolutional codes and linear systems over certain rings, and we show that every locally Brunovsky linear system may be considered as a representation of a code under feedback convolutional equivalence.

  2. Biological equivalence between LDR and PDR in cervical cancer: multifactor analysis using the linear-quadratic model

    Directory of Open Access Journals (Sweden)

    José Guilherme Couto

    2011-09-01

    Full Text Available Purpose: The purpose of this work was the biological comparison between Low Dose Rate (LDR and Pulsed DoseRate (PDR in cervical cancer regarding the discontinuation of the afterloading system used for the LDR treatments atour Institution since December 2009. Material and methods: In the first phase we studied the influence of the pulse dose and the pulse time in the biologicalequivalence between LDR and PDR treatments using the Linear Quadratic Model (LQM. In the second phase,the equivalent dose in 2 Gy/fraction (EQD2 for the tumor, rectum and bladder in treatments performed with both techniqueswas evaluated and statistically compared. All evaluated patients had stage IIB cervical cancer and were treatedwith External Beam Radiotherapy (EBRT plus two Brachytherapy (BT applications. Data were collected from 48 patients(26 patients treated with LDR and 22 patients with PDR. Results: In the analyses of the influence of PDR parameters in the biological equivalence between LDR and PDRtreatments (Phase 1, it was calculated that if the pulse dose in PDR was kept equal to the LDR dose rate, a small therapeuticloss was expected. If the pulse dose was decreased, the therapeutic window became larger, but a correction inthe prescribed dose was necessary. In PDR schemes with 1 hour interval between pulses, the pulse time did not influencesignificantly the equivalent dose. In the comparison between the groups treated with LDR and PDR (Phase 2 weconcluded that they were not equivalent, because in the PDR group the total EQD2 for the tumor, rectum and bladderwas smaller than in the LDR group; the LQM estimated that a correction in the prescribed dose of 6% to 10% was ne -cessary to avoid therapeutic loss. Conclusions: A correction in the prescribed dose was necessary; this correction should be achieved by calculatingthe PDR dose equivalent to the desired LDR total dose.

  3. Therapeutic and diagnostic nanomaterials

    CERN Document Server

    Devasena T

    2017-01-01

    This brief highlights nanoparticles used in the diagnosis and treatment of prominent diseases and toxic conditions. Ecofriendly methods which are ideal for the synthesis of medicinally valued nanoparticles are explained and the characteristic features of these particles projected. The role of these particles in the therapeutic field, and the induced biological changes in some diseases are discussed. The main focus is on inflammation, oxidative stress and cellular membrane integrity alterations. The effect of nanoparticles on these changes produced by various agents are highlighted using in vitro and in vivo models. The mechanism of nanoparticles in ameliorating the biological changes is supported by relevant images and data. Finally, the brief demonstrates recent developments on the use of nanoparticles in diagnosis or sensing of some biological materials and biologically hazardous environmental materials.

  4. Antibody Engineering and Therapeutics

    Science.gov (United States)

    Almagro, Juan Carlos; Gilliland, Gary L; Breden, Felix; Scott, Jamie K; Sok, Devin; Pauthner, Matthias; Reichert, Janice M; Helguera, Gustavo; Andrabi, Raiees; Mabry, Robert; Bléry, Mathieu; Voss, James E; Laurén, Juha; Abuqayyas, Lubna; Barghorn, Stefan; Ben-Jacob, Eshel; Crowe, James E; Huston, James S; Johnston, Stephen Albert; Krauland, Eric; Lund-Johansen, Fridtjof; Marasco, Wayne A; Parren, Paul WHI; Xu, Kai Y

    2014-01-01

    The 24th Antibody Engineering & Therapeutics meeting brought together a broad range of participants who were updated on the latest advances in antibody research and development. Organized by IBC Life Sciences, the gathering is the annual meeting of The Antibody Society, which serves as the scientific sponsor. Preconference workshops on 3D modeling and delineation of clonal lineages were featured, and the conference included sessions on a wide variety of topics relevant to researchers, including systems biology; antibody deep sequencing and repertoires; the effects of antibody gene variation and usage on antibody response; directed evolution; knowledge-based design; antibodies in a complex environment; polyreactive antibodies and polyspecificity; the interface between antibody therapy and cellular immunity in cancer; antibodies in cardiometabolic medicine; antibody pharmacokinetics, distribution and off-target toxicity; optimizing antibody formats for immunotherapy; polyclonals, oligoclonals and bispecifics; antibody discovery platforms; and antibody-drug conjugates. PMID:24589717

  5. Therapeutic applications of melatonin

    Science.gov (United States)

    2013-01-01

    Melatonin is a methoxyindole synthesized within the pineal gland. The hormone is secreted during the night and appears to play multiple roles within the human organism. The hormone contributes to the regulation of biological rhythms, may induce sleep, has strong antioxidant action and appears to contribute to the protection of the organism from carcinogenesis and neurodegenerative disorders. At a therapeutic level as well as in prevention, melatonin is used for the management of sleep disorders and jet lag, for the resynchronization of circadian rhythms in situations such as blindness and shift work, for its preventive action in the development of cancer, as additive therapy in cancer and as therapy for preventing the progression of Alzheimer’s disease and other neurodegenerative disorders. PMID:23515203

  6. Microfabricated therapeutic actuators

    Science.gov (United States)

    Lee, Abraham P.; Northrup, M. Allen; Ciarlo, Dino R.; Krulevitch, Peter A.; Benett, William J.

    1999-01-01

    Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a release actuator for the delivery of embolic coils through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use.

  7. Therapeutic effects of reading

    Directory of Open Access Journals (Sweden)

    Agustín HIDALGO

    2017-06-01

    Full Text Available Reading is an act that requires isolation and loneliness, which allows rewriting the narratives through the identification between the reader and the character, the involvement in the fact narrated and singular recreation by every single reader. The act of reading allows stepping aside from reality. The reading as well as the writing perform the therapeutic effect of helping to understand the illness and to know experiences of others patients that can be useful for the accompaniment, overcoming and/or making decisions. There is not a concrete literary that could be universally recommend to every patient, but all the genre can be useful to some patient. However, poetry, novel and autobiographies are frequently referred as the manuscripts that provide help and consolation.

  8. Antiviral Polymer Therapeutics

    DEFF Research Database (Denmark)

    Smith, Anton Allen Abbotsford

    2014-01-01

    polymerized in a controlled manner with carrier monomers of historically proven biocompatible polymers. The carrier polymers, the loading of ribavirin as well as the size of the polymer were varied systematically with the aid of an automated synthesis platform. These polymers were tested in a cellular assay...... of reversible-addition-fragmentation chain transfer polymerization, which not only controls the size of polymer, but also allows the introduction of a terminal amine on the polymer which can be used for further conjugation. This has allowed for not only fluorescent labeling of the polymer, but also protein......The field of drug delivery is in essence an exercise in engineered pharmacokinetics. Methods of doing so have been developed through the introduction of a vehicle carrying the drug, either by encapsulation or covalent attachment. The emergence of polymer therapeutics in anticancer therapy has...

  9. Therapeutic Approaches in CLIPPERS.

    Science.gov (United States)

    Taieb, Guillaume; Allou, Thibaut; Labauge, Pierre

    2017-05-01

    CLIPPERS for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, is a steroid-sensitive and steroid-dependent brainstem inflammatory disease of unknown origin. Since its first description in 2010, about 60 cases have been reported throughout the world. The mean age at onset is 50 years and men seem to be more frequently affected. In patients without chronic corticosteroid therapy or immunosuppressive agents, the disease had a relapsing remitting course, and the mean annualized relapse rate was 0.5. During attacks, although clinical and radiological improvement after high doses of corticosteroids was systematically observed, patients could display subsequent disability and hindbrain atrophy. Since no progressive course was observed, clinical and radiological sequelae were correlated with previous severe attacks. Therefore, maintaining the disease in remission may prevent the accumulation of disability. In the literature, no relapse occurred when chronic corticosteroid therapy was maintained above 20 mg per day. However, steroids side effects led to propose corticosteroid-sparing therapies. Unfortunately, no controlled therapy studies for CLIPPERS have been performed yet, and no therapeutic recommendations exist. Using the PubMed database, all articles having the following keywords "chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids" and "CLIPPERS" have been analysed. Considering that the mean annual relapse rate was 0.5, and that no relapse occurred when corticosteroid therapy was maintained above 20 mg per day, the therapeutic efficiency of corticosteroid-sparing agents was considered as "probable" when patients had a relapse-free period ≥24 months, in the absence of concomitant corticosteroid therapy. Corticosteroid-sparing agents whose efficiency is "probable" are methotrexate in two cases, cyclophosphamide in one case and hydroxychloroquine in one case. Considering the

  10. ASCERTAINMENT OF THE EQUIVALENT CIRCUIT PARAMETERS OF THE ASYNCHRONOUS MACHINE

    Directory of Open Access Journals (Sweden)

    V. S. Safaryan

    2015-01-01

    Full Text Available The article considers experimental and analytical determination of the asynchronous machine equivalent-circuit parameters with application of the reference data. Transient processes investigation of the asynchronous machines necessitates the equivalent circuit parameters (resistance impedance, inductances and coefficient of the stator-rotor contours mutual inductance that help form the transitory-process mathematical simulation model. The reference books do not provide those parameters; they instead give the rated ones (active power, voltage, slide, coefficient of performance and capacity coefficient as well as the ratio of starting and nominal currents and torques. The noted studies on the asynchronous machine equivalent-circuits parametrization fail to solve the problems ad finem or solve them with admissions. The paper presents experimental and analytical determinations of the asynchronous machine equivalent-circuit parameters: the experimental one based on the results of two measurements and the analytical one where the problem boils down to solving a system of nonlineal algebraic equations. The authors investigate the equivalent asynchronous machine input-resistance properties and adduce the dependence curvatures of the input-resistances on the slide. They present a symbolic model for analytical parameterization of the asynchronous machine equivalent-circuit that represents a system of nonlineal equations and requires one of the rotor-parameters arbitrary assignment. The article demonstrates that for the asynchronous machine equivalent-circuit experimental parameterization the measures are to be conducted of the stator-circuit voltage, current and active power with two different slides and arbitrary assignment of one of the rotor parameters. The paper substantiates the fact that additional measurement does not discard the rotor-parameter choice arbitrariness. The authors establish that in motoring mode there is a critical slide by which the

  11. Validity of the Aluminum Equivalent Approximation in Space Radiation Shielding

    Science.gov (United States)

    Badavi, Francis F.; Adams, Daniel O.; Wilson, John W.

    2009-01-01

    The origin of the aluminum equivalent shield approximation in space radiation analysis can be traced back to its roots in the early years of the NASA space programs (Mercury, Gemini and Apollo) wherein the primary radiobiological concern was the intense sources of ionizing radiation causing short term effects which was thought to jeopardize the safety of the crew and hence the mission. Herein, it is shown that the aluminum equivalent shield approximation, although reasonably well suited for that time period and to the application for which it was developed, is of questionable usefulness to the radiobiological concerns of routine space operations of the 21 st century which will include long stays onboard the International Space Station (ISS) and perhaps the moon. This is especially true for a risk based protection system, as appears imminent for deep space exploration where the long-term effects of Galactic Cosmic Ray (GCR) exposure is of primary concern. The present analysis demonstrates that sufficiently large errors in the interior particle environment of a spacecraft result from the use of the aluminum equivalent approximation, and such approximations should be avoided in future astronaut risk estimates. In this study, the aluminum equivalent approximation is evaluated as a means for estimating the particle environment within a spacecraft structure induced by the GCR radiation field. For comparison, the two extremes of the GCR environment, the 1977 solar minimum and the 2001 solar maximum, are considered. These environments are coupled to the Langley Research Center (LaRC) deterministic ionized particle transport code High charge (Z) and Energy TRaNsport (HZETRN), which propagates the GCR spectra for elements with charges (Z) in the range I aluminum equivalent approximation for a good polymeric shield material such as genetic polyethylene (PE). The shield thickness is represented by a 25 g/cm spherical shell. Although one could imagine the progression to greater

  12. (In)validity of large N orientifold equivalence

    Science.gov (United States)

    Ünsal, Mithat; Yaffe, Laurence G.

    2006-11-01

    It has been argued that the bosonic sectors of supersymmetric SU(N) Yang-Mills theory, and of QCD with a single fermion in the antisymmetric (or symmetric) tensor representation, are equivalent in the N→∞ limit. If true, this correspondence can provide useful insight into properties of real QCD (with fundamental representation fermions), such as predictions [with O(1/N) corrections] for the nonperturbative vacuum energy, the chiral condensate, and a variety of other observables. Several papers asserting to have proven this large N “orientifold equivalence” have appeared. By considering theories compactified on R3×S1, we show explicitly that this large N equivalence fails for sufficiently small radius, where our analysis is reliable, due to spontaneous symmetry breaking of charge-conjugation symmetry in QCD with an antisymmetric (or symmetric) tensor representation fermion. This theory is also chirally symmetric for small radius, unlike super-Yang-Mills theory. The situation is completely analogous to large-N equivalences based on orbifold projections: simple symmetry realization conditions are both necessary and sufficient for the validity of the large N equivalence. Whether these symmetry realization conditions are satisfied depends on the specific nonperturbative dynamics of the theory under consideration. Unbroken charge-conjugation symmetry is necessary for validity of the large N orientifold equivalence. Whether or not this condition is satisfied on R4 (or R3×S1 for sufficiently large radius) is not currently known.

  13. Diminished acquired equivalence yet good discrimination performance in older participants

    Directory of Open Access Journals (Sweden)

    Jasper eRobinson

    2013-10-01

    Full Text Available We asked younger and older human participants to perform computer-based configural discriminations that were designed to detect acquired equivalence. Both groups solved the discriminations but only the younger participants demonstrated acquired equivalence. The discriminations involved learning the preferences (‘like’ [+] or ‘dislike’ [-] for sports (e.g., tennis [t] and hockey [h] of four fictitious people (e.g., Alice [A], Beth [B], Charlotte [C] & Dorothy [D]. In one experiment, the discrimination had the form: At+, Bt-, Ct+, Dt-, Ah-, Bh+, Ch-, Dh+. Notice that, e.g., Alice and Charlotte are ‘equivalent’ in liking tennis but disliking hockey. Acquired equivalence was assessed in ancillary components of the discrimination (e.g., by looking at the subsequent rate of ‘whole’ versus ‘partial’ reversal learning. Acquired equivalence is anticipated by a network whose hidden units are shared when inputs (e.g., A and C signal the same outcome (e.g., + when accompanied by the same input (t. One interpretation of these results is that there are age-related differences in the mechanisms of configural acquired equivalence.

  14. Sequential time interleaved random equivalent sampling for repetitive signal

    Science.gov (United States)

    Zhao, Yijiu; Liu, Jingjing

    2016-12-01

    Compressed sensing (CS) based sampling techniques exhibit many advantages over other existing approaches for sparse signal spectrum sensing; they are also incorporated into non-uniform sampling signal reconstruction to improve the efficiency, such as random equivalent sampling (RES). However, in CS based RES, only one sample of each acquisition is considered in the signal reconstruction stage, and it will result in more acquisition runs and longer sampling time. In this paper, a sampling sequence is taken in each RES acquisition run, and the corresponding block measurement matrix is constructed using a Whittaker-Shannon interpolation formula. All the block matrices are combined into an equivalent measurement matrix with respect to all sampling sequences. We implemented the proposed approach with a multi-cores analog-to-digital converter (ADC), whose ADC cores are time interleaved. A prototype realization of this proposed CS based sequential random equivalent sampling method has been developed. It is able to capture an analog waveform at an equivalent sampling rate of 40 GHz while sampled at 1 GHz physically. Experiments indicate that, for a sparse signal, the proposed CS based sequential random equivalent sampling exhibits high efficiency.

  15. A Cp-theory problem book functional equivalencies

    CERN Document Server

    Tkachuk, Vladimir V

    2016-01-01

    This fourth volume in Vladimir Tkachuk's series on Cp-theory gives reasonably complete coverage of the theory of functional equivalencies through 500 carefully selected problems and exercises. By systematically introducing each of the major topics of Cp-theory, the book is intended to bring a dedicated reader from basic topological principles to the frontiers of modern research. The book presents complete and up-to-date information on the preservation of topological properties by homeomorphisms of function spaces.  An exhaustive theory of t-equivalent, u-equivalent and l-equivalent spaces is developed from scratch.   The reader will also find introductions to the theory of uniform spaces, the theory of locally convex spaces, as well as  the theory of inverse systems and dimension theory. Moreover, the inclusion of Kolmogorov's solution of Hilbert's Problem 13 is included as it is needed for the presentation of the theory of l-equivalent spaces. This volume contains the most important classical re...

  16. Higher-order gravity and the classical equivalence principle

    Science.gov (United States)

    Accioly, Antonio; Herdy, Wallace

    2017-11-01

    As is well known, the deflection of any particle by a gravitational field within the context of Einstein’s general relativity — which is a geometrical theory — is, of course, nondispersive. Nevertheless, as we shall show in this paper, the mentioned result will change totally if the bending is analyzed — at the tree level — in the framework of higher-order gravity. Indeed, to first order, the deflection angle corresponding to the scattering of different quantum particles by the gravitational field mentioned above is not only spin dependent, it is also dispersive (energy-dependent). Consequently, it violates the classical equivalence principle (universality of free fall, or equality of inertial and gravitational masses) which is a nonlocal principle. However, contrary to popular belief, it is in agreement with the weak equivalence principle which is nothing but a statement about purely local effects. It is worthy of note that the weak equivalence principle encompasses the classical equivalence principle locally. We also show that the claim that there exists an incompatibility between quantum mechanics and the weak equivalence principle, is incorrect.

  17. Equivalent-Continuum Modeling With Application to Carbon Nanotubes

    Science.gov (United States)

    Odegard, Gregory M.; Gates, Thomas S.; Nicholson, Lee M.; Wise, Kristopher E.

    2002-01-01

    A method has been proposed for developing structure-property relationships of nano-structured materials. This method serves as a link between computational chemistry and solid mechanics by substituting discrete molecular structures with equivalent-continuum models. It has been shown that this substitution may be accomplished by equating the vibrational potential energy of a nano-structured material with the strain energy of representative truss and continuum models. As important examples with direct application to the development and characterization of single-walled carbon nanotubes and the design of nanotube-based devices, the modeling technique has been applied to determine the effective-continuum geometry and bending rigidity of a graphene sheet. A representative volume element of the chemical structure of graphene has been substituted with equivalent-truss and equivalent continuum models. As a result, an effective thickness of the continuum model has been determined. This effective thickness has been shown to be significantly larger than the interatomic spacing of graphite. The effective thickness has been shown to be significantly larger than the inter-planar spacing of graphite. The effective bending rigidity of the equivalent-continuum model of a graphene sheet was determined by equating the vibrational potential energy of the molecular model of a graphene sheet subjected to cylindrical bending with the strain energy of an equivalent continuum plate subjected to cylindrical bending.

  18. Inertia and Double Bending of Light from Equivalence

    Science.gov (United States)

    Shuler, Robert L., Jr.

    2010-01-01

    Careful examination of light paths in an accelerated reference frame, with use of Special Relativity, can account fully for the observed bending of light in a gravitational field, not just half of it as reported in 1911. This analysis also leads to a Machian formulation of inertia similar to the one proposed by Einstein in 1912 and later derived from gravitational field equations in Minkowsky Space by Sciama in 1953. There is a clear inference from equivalence that there is some type of inertial mass increase in a gravitational field. It is the purpose of the current paper to suggest that equivalence provides a more complete picture of gravitational effects than previously thought, correctly predicting full light bending, and that since the theory of inertia is derivable from equivalence, any theory based on equivalence must take account of it. Einstein himself clearly was not satisfied with the status of inertia in GRT, as our quotes have shown. Many have tried to account for inertia and met with less than success, for example Davidson s integration of Sciama s inertia into GRT but only for a steady state cosmology [10], and the Machian gravity theory of Brans and Dicke [11]. Yet Mach s idea hasn t gone away, and now it seems that it cannot go away without also disposing of equivalence.

  19. Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics.

    Science.gov (United States)

    Rocco, C J; Davey, M E; Bakaletz, L O; Goodman, S D

    2017-04-01

    Bacteria that persist in the oral cavity exist within complex biofilm communities. A hallmark of biofilms is the presence of an extracellular polymeric substance (EPS), which consists of polysaccharides, extracellular DNA (eDNA), and proteins, including the DNABII family of proteins. The removal of DNABII proteins from a biofilm results in the loss of structural integrity of the eDNA and the collapse of the biofilm structure. We examined the role of DNABII proteins in the biofilm structure of the periodontal pathogen Porphyromonas gingivalis and the oral commensal Streptococcus gordonii. Co-aggregation with oral streptococci is thought to facilitate the establishment of P. gingivalis within the biofilm community. We demonstrate that DNABII proteins are present in the EPS of both S. gordonii and P. gingivalis biofilms, and that these biofilms can be disrupted through the addition of antisera derived against their respective DNABII proteins. We provide evidence that both eDNA and DNABII proteins are limiting in S. gordonii but not in P. gingivalis biofilms. In addition, these proteins are capable of complementing one another functionally. We also found that whereas antisera derived against most DNABII proteins are capable of binding a wide variety of DNABII proteins, the P. gingivalis DNABII proteins are antigenically distinct. The presence of DNABII proteins in the EPS of these biofilms and the antigenic uniqueness of the P. gingivalis proteins provide an opportunity to develop therapies that are targeted to remove P. gingivalis and biofilms that contain P. gingivalis from the oral cavity. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. [Nuclear transfer and therapeutic cloning].

    Science.gov (United States)

    Xu, Xiao-Ming; Lei, An-Min; Hua, Jin-Lian; Dou, Zhong-Ying

    2005-03-01

    Nuclear transfer and therapeutic cloning have widespread and attractive prospects in animal agriculture and biomedical applications. We reviewed that the quality of oocytes and nuclear reprogramming of somatic donor cells were the main reasons of the common abnormalities in cloned animals and the low efficiency of cloning and showed the problems and outlets in therapeutic cloning, such as some basic problems in nuclear transfer affected clinical applications of therapeutic cloning. Study on isolation and culture of nuclear transfer embryonic stem (ntES) cells and specific differentiation of ntES cells into important functional cells should be emphasized and could enhance the efficiency. Adult stem cells could help to cure some great diseases, but could not replace therapeutic cloning. Ethics also impeded the development of therapeutic cloning. It is necessary to improve many techniques and reinforce the research of some basic theories, then somatic nuclear transfer and therapeutic cloning may apply to agriculture reproduction and benefit to human life better.

  1. Therapeutic vaccines for leishmaniasis.

    Science.gov (United States)

    Khamesipour, Ali

    2014-11-01

    Numerous therapeutic strategies are used to treat leishmaniasis. The treatment of cutaneous leishmaniasis (CL) is solely depends on antimonate derivatives with safety issues and questionable efficacy and there is no fully effective modality to treat CL caused by Leishmania tropica and Leishmania braziliensis. There is no prophylactic vaccine available against any form of leishmaniasis. Immunotherapy for CL has a long history; immunotherapy trials of first and second generation vaccines showed promising results. The current article briefly covers the prophylactic vaccines and explains different immunotherapy strategies that have been used to treat leishmaniasis. This paper does not include experimental vaccines and only lays emphasis on human trials and those vaccines which reached human trials. Immunotherapy is currently used to successfully treat several disorders; Low cost, limited side effects and no possibility to develop resistance make immunotherapy a valuable choice especially for infectious disease with chemotherapy problems. Efforts are needed to explore the immunological surrogate marker(s) of cure and protection in leishmaniasis and overcome the difficulties in standardization of crude Leishmania vaccines. One of the reasons for anti-leishmaniasis vaccine failure is lack of an appropriate adjuvant. So far, not enough attention has been paid to develop vaccines for immunotherapy of leishmaniasis.

  2. Kinetoplastida: new therapeutic strategies

    Directory of Open Access Journals (Sweden)

    Croft S.L.

    2008-09-01

    Full Text Available New formulations and therapeutic switching of the established drugs, amphotericin B and paromomycin, together with the discovery of miltefosine, have significantly improved the opportunities for treatment of visceral leishmaniasis (VL chemotherapy. However, for human African trypanosomiasis (HAT, Chagas disease and cutaneous leishmaniases there has been limited progress. For HAT, a novel diamidine, parfuramidine, is in phase III clinical trial for early-stage disease, but for the treatment of late-stage disease there are no new drugs and combinations of eflornithine with melarsoprol or nifurtimox have been the focus of clinical studies. For Chagas disease, different classes of compounds that have validated biochemical targets, sterol biosynthesis methylases and cysteine proteases, are in various stages of development. The genome sequences that are now available for the pathogens that cause the leishmaniases and trypanosomiases, and new methods for rapid validation of targets, are part of the solution to discover new drugs. The integration of medicinal chemistry, pharmacokinetics, project planning and interaction with the pharma/biotech sector are essential if progress is to be made. Although there are financial constraints, the appearance of new funding sources and not-for-profit product development partnerships offers hope for drug development.

  3. Therapeutic uses of magnesium.

    Science.gov (United States)

    Guerrera, Mary P; Volpe, Stella Lucia; Mao, Jun James

    2009-07-15

    Magnesium is an essential mineral for optimal metabolic function. Research has shown that the mineral content of magnesium in food sources is declining, and that magnesium depletion has been detected in persons with some chronic diseases. This has led to an increased awareness of proper magnesium intake and its potential therapeutic role in a number of medical conditions. Studies have shown the effectiveness of magnesium in eclampsia and preeclampsia, arrhythmia, severe asthma, and migraine. Other areas that have shown promising results include lowering the risk of metabolic syndrome, improving glucose and insulin metabolism, relieving symptoms of dysmenorrhea, and alleviating leg cramps in women who are pregnant. The use of magnesium for constipation and dyspepsia are accepted as standard care despite limited evidence. Although it is safe in selected patients at appropriate dosages, magnesium may cause adverse effects or death at high dosages. Because magnesium is excreted renally, it should be used with caution in patients with kidney disease. Food sources of magnesium include green leafy vegetables, nuts, legumes, and whole grains.

  4. Leech Therapeutic Applications

    Science.gov (United States)

    Abdualkader, A. M.; Ghawi, A. M.; Alaama, M.; Awang, M.; Merzouk, A.

    2013-01-01

    Hematophagous animals including leeches have been known to possess biologically active compounds in their secretions, especially in their saliva. The blood-sucking annelids, leeches have been used for therapeutic purposes since the beginning of civilization. Ancient Egyptian, Indian, Greek and Arab physicians used leeches for a wide range of diseases starting from the conventional use for bleeding to systemic ailments, such as skin diseases, nervous system abnormalities, urinary and reproductive system problems, inflammation, and dental problems. Recently, extensive researches on leech saliva unveiled the presence of a variety of bioactive peptides and proteins involving antithrombin (hirudin, bufrudin), antiplatelet (calin, saratin), factor Xa inhibitors (lefaxin), antibacterial (theromacin, theromyzin) and others. Consequently, leech has made a comeback as a new remedy for many chronic and life-threatening abnormalities, such as cardiovascular problems, cancer, metastasis, and infectious diseases. In the 20th century, leech therapy has established itself in plastic and microsurgery as a protective tool against venous congestion and served to salvage the replanted digits and flaps. Many clinics for plastic surgery all over the world started to use leeches for cosmetic purposes. Despite the efficacious properties of leech therapy, the safety, and complications of leeching are still controversial. PMID:24019559

  5. Wave propagation in equivalent continuums representing truss lattice materials

    Energy Technology Data Exchange (ETDEWEB)

    Messner, Mark C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Barham, Matthew I. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kumar, Mukul [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Barton, Nathan R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-07-29

    Stiffness scales linearly with density in stretch-dominated lattice meta-materials offering the possibility of very light yet very stiff structures. Current additive manufacturing techniques can assemble structures consisting of these lattice materials, but the design of such structures will require accurate, efficient simulation techniques. Equivalent continuum models have several advantages over discrete truss models of stretch dominated lattices, including computational efficiency and ease of model construction. However, the development an equivalent model suitable for representing the dynamic response of a periodic truss is complicated by microinertial effects. This paper derives a dynamic equivalent continuum model for periodic truss structures and verifies it against detailed finite element simulations. The model must incorporate microinertial effects to accurately reproduce long-wavelength characteristics of the response such as anisotropic elastic soundspeeds. The formulation presented here also improves upon previous work by preserving equilibrium at truss joints for affine lattice deformation and by improving numerical stability by eliminating vertices in the effective yield surface.

  6. Equivalent medium theory of layered sphere particle with anisotropic shells

    Science.gov (United States)

    Li, Xingcai; Wang, Minzhong; Zhang, Beidou

    2016-08-01

    Researches on the optical properties of small particle have been widely concerned in the atmospheric science, astronomy, astrophysics, biology and medical science. This paper provides an equivalent dielectric theory for the functional graded particle with anisotropic shells, in which inhomogeneous and anisotropic particle was equivalently transformed into a new kind of homogeneous, continuous and isotropic sphere with same size but different permittivity, and then greatly simplify the calculation process of particle's optical property. Meanwhile, the paper also discusses whether the charge on the particle can change the expression of its equivalent permittivity or not. These results proposed in this paper can be used to simulate the electrical, optical properties of layered sphere, it also meet the research requirement in the design of functional graded particles in different subjects.

  7. Functional explanation and the problem of functional equivalence.

    Science.gov (United States)

    DiFrisco, James

    2017-10-01

    The legitimacy of functional explanations in biology is threatened by a problem first identified by Hempel: the problem of functional equivalence. In order for the prevalence of a trait to be explained by its function, the function would have to explain why that very trait is prevalent and not some other functionally equivalent trait. But functions alone cannot meet this explanatory demand. I argue that this is a problem not only for Nagelian deductive-nomological models but also for etiological models of functional explanation. I contrast these models with a dual model of adaptive explanation and design explanation. This dual model largely circumvents the problem of functional equivalence, but divests functions of much explanatory power. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Reduction of Linear Functional Systems using Fuhrmann's Equivalence

    Directory of Open Access Journals (Sweden)

    Mohamed S. Boudellioua

    2016-11-01

    Full Text Available Functional systems arise in the treatment of systems of partial differential equations, delay-differential equations, multidimensional equations, etc. The problem of reducing a linear functional system to a system containing fewer equations and unknowns was first studied by Serre. Finding an equivalent presentation of a linear functional system containing fewer equations and fewer unknowns can generally simplify both the study of the structural properties of the linear functional system and of different numerical analysis issues, and it can sometimes help in solving the linear functional system. In this paper, Fuhrmann's equivalence is used to present a constructive result on the reduction of under-determined linear functional systems to a single equation involving a single unknown. This equivalence transformation has been studied by a number of authors and has been shown to play an important role in the theory of linear functional systems.

  9. Equivalence Principles, Spacetime Structure and the Cosmic Connection

    CERN Document Server

    Ni, Wei-Tou

    2015-01-01

    After reviewing the meaning of various equivalence principles and the structure of electrodynamics, we give a fairly detailed account of the construction of the light cone and a core metric from the equivalence principle for the photon (no birefringence, no polarization rotation and no amplification/attenuation in propagation) in the framework of linear electrodynamics using cosmic connections/observations as empirical support. The cosmic nonbirefringent propagation of photons independent of energy and polarization verifies the Galileo Equivalence Principle [Universality of Propagation] for photons/electromagnetic wave packets in spacetime. This nonbirefringence constrains the spacetime constitutive tensor to high precision to a core metric form with an axion degree and a dilaton degree of freedom. Thus comes the metric with axion and dilation. Constraints on axion and dilaton from astrophysical/cosmic propagation are reviewed. E\\"otv\\"os-type experiments, Hughes-Drever-type experiments, redshift experiments ...

  10. Mesoscale symmetries explain dynamical equivalence of food webs

    CERN Document Server

    Aufderheide, Helge; Gross, Thilo

    2012-01-01

    A present challenge in complex systems is to identify mesoscale structures that have distinct dynamical implications. In this paper we present a detailed investigation of a previously observed dynamical equivalence of certian ecological food webs. We show that this equivalence is rooted in mesoscale symmetries that exist in these webs. Certain eigenvectors of the Jacobian describing dynamical modes of the system, such as specific instabilities or responses to perturbations, localize on these symmetric motifs. On the one hand this means that by removing a symmetry from the network one obtains a system which has identical dynamics except for the removal of the localized mode. This explains the previously observed equivalence. On the other hand it means that we can identify dynamical modes that only depend on the symmetric motif. Symmetric structures thus provide an example for mesoscale network motifs having distinct and exact implications for the dynamics.

  11. Some new results on Borel irreducibility of equivalence relations

    Science.gov (United States)

    Kanovei, Vladimir G.; Reeken, M.

    2003-02-01

    We prove that orbit equivalence relations (ERs, for brevity) of generically turbulent Polish actions are not Borel reducible to ERs of a family which includes Polish actions of S_\\infty (the group of all permutations of \\mathbb N and is closed under the Fubini product modulo the ideal Fin of all finite sets and under some other operations. We show that \\mathsf T_2 (an equivalence relation called the equality of countable sets of reals is not Borel reducible to another family of ERs which includes continuous actions of Polish CLI groups, Borel equivalence relations with \\mathbf G_{\\delta\\sigma} classes and some ideals, and is closed under the Fubini product modulo Fin. These results and their corollaries extend some earlier irreducibility theorems of Hjorth and Kechris.

  12. Therapeutic cloning in the mouse

    Science.gov (United States)

    Mombaerts, Peter

    2003-01-01

    Nuclear transfer technology can be applied to produce autologous differentiated cells for therapeutic purposes, a concept termed therapeutic cloning. Countless articles have been published on the ethics and politics of human therapeutic cloning, reflecting the high expectations from this new opportunity for rejuvenation of the aging or diseased body. Yet the research literature on therapeutic cloning, strictly speaking, is comprised of only four articles, all in the mouse. The efficiency of derivation of embryonic stem cell lines via nuclear transfer is remarkably consistent among these reports. However, the efficiency is so low that, in its present form, the concept is unlikely to become widespread in clinical practice. PMID:12949262

  13. The equivalence myth of quantum mechanics-part II

    Science.gov (United States)

    Muller, F. A.

    The author endeavours to show two things: first, that Schrödingers (and Eckarts) demonstration in March (September) 1926 of the equivalence of matrix mechanics, as created by Heisenberg, Born, Jordan and Dirac in 1925, and wave mechanics, as created by Schrödinger in 1926, is not foolproof; and second, that it could not have been foolproof, because at the time matrix mechanics and wave mechanics were neither mathematically nor empirically equivalent. That they were is the Equivalence Myth. In order to make the theories equivalent and to prove this, one has to leave the historical scene of 1926 and wait until 1932, when von Neumann finished his magisterial edifice. During the period 1926-1932 the original families of mathematical structures of matrix mechanics and of wave mechanics were stretched, parts were chopped off and novel structures were added. To Procrustean places we go, where we can demonstrate the mathematical, empirical and ontological equivalence of 'the final versions of' matrix mechanics and wave mechanics. The present paper claims to be a comprehensive analysis of one of the pivotal papers in the history of quantum mechanics: Schrödingers equivalence paper. Since the analysis is performed from the perspective of Suppes structural view ('semantic view') of physical theories, the present paper can be regarded not only as a morsel of the internal history of quantum mechanics, but also as a morsel of applied philosophy of science. The paper is self-contained and presupposes only basic knowledge of quantum mechanics. For reasons of length, the paper is published in two parts; Part I appeared in the previous issue of this journal. Section 1 contains, besides an introduction, also the papers five claims and a preview of the arguments supporting these claims; so Part I, Section 1 may serve as a summary of the paper for those readers who are not interested in the detailed arguments.

  14. The European Person Equivalent: Measuring the personal environmental space

    DEFF Research Database (Denmark)

    Hauschild, Michael Zwicky; Wenzel, Henrik

    2001-01-01

    European person equivalent is a quantification of the average person’s environmental impact in a near future according to the current politically set environmental targets. In addition to expressing the current societal priorities in pollution reduction, the targeted PE expresses the environmental space...... and interpretation of environmental impacts from all kinds of man-made activities, technologies and systems. The paper presents the determination of the person equivalents for different impact categories and consumption of resources. Its relation to the sustainability-based ecological space and its use as a common...... yardstick for industry in the presentation and comparison of environmental impact are discussed....

  15. Categorical Equivalence Between Orthomodular Dynamic Algebras and Complete Orthomodular Lattices

    Science.gov (United States)

    Kishida, Kohei; Rafiee Rad, Soroush; Sack, Joshua; Zhong, Shengyang

    2017-12-01

    This paper provides a categorical equivalence between two types of quantum structures. One is a complete orthomodular lattice, which is used for reasoning about testable properties of a quantum system. The other is an orthomodular dynamic algebra, which is a quantale used for reasoning about quantum actions. The result extends to more restrictive lattices than orthomodular lattices, and includes Hilbert lattices of closed subspaces of a Hilbert space. These other lattice structures have connections to a wide range of different quantum structures; hence our equivalence establishes a categorical connection between quantales and a great variety of quantum structures.

  16. Equivalent Lagrangian densities and invariant collective coordinates equations

    Energy Technology Data Exchange (ETDEWEB)

    Zamora-Sillero, ElIas [Department of Biochemistry, University of Zurich, Building 27 Winterthurerstrasse 190 CH-8057, Zurich (Switzerland); Shapovalov, Alexander V, E-mail: e.zamora@bioc.uzh.ch, E-mail: shpv@phys.tsu.ru [Laboratory of Mathematical Physics, Tomsk Polytechnical University, Tomsk (Russian Federation)

    2011-02-11

    In the framework of the Lagrangian formalism the partial differential equation under study does not define univocally the Lagrangian density. In this paper we obtain a necessary and sufficient consistency condition over the ansatz that assures the invariance of the collective coordinates (CCs) equations under the change of equivalent Lagrangian densities. When this condition is not fulfilled we show explicitly that different equations of CCs may emerge from equivalent Lagrangian densities and a good agreement between the CCs and the partial differential equations is not expected.

  17. Electric circuit networks equivalent to chaotic quantum billiards.

    Science.gov (United States)

    Bulgakov, Evgeny N; Maksimov, Dmitrii N; Sadreev, Almas F

    2005-04-01

    We consider two electric RLC resonance networks that are equivalent to quantum billiards. In a network of inductors grounded by capacitors, the eigenvalues of the quantum billiard correspond to the squared resonant frequencies. In a network of capacitors grounded by inductors, the eigenvalues of the billiard are given by the inverse of the squared resonant frequencies. In both cases, the local voltages play the role of the wave function of the quantum billiard. However, unlike for quantum billiards, there is a heat power because of the resistance of the inductors. In the equivalent chaotic billiards, we derive a distribution of the heat power which describes well the numerical statistics.

  18. A weak equivalence principle test on a suborbital rocket

    Energy Technology Data Exchange (ETDEWEB)

    Reasenberg, Robert D; Phillips, James D, E-mail: reasenberg@cfa.harvard.ed [Smithsonian Astrophysical Observatory, Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

    2010-05-07

    We describe a Galilean test of the weak equivalence principle, to be conducted during the free fall portion of a sounding rocket flight. The test of a single pair of substances is aimed at a measurement uncertainty of sigma(eta) < 10{sup -16} after averaging the results of eight separate drops. The weak equivalence principle measurement is made with a set of four laser gauges that are expected to achieve 0.1 pm Hz{sup -1/2}. The discovery of a violation (eta not = 0) would have profound implications for physics, astrophysics and cosmology.

  19. A weak equivalence principle test on a suborbital rocket

    CERN Document Server

    Reasenberg, Robert D

    2010-01-01

    We describe a Galilean test of the weak equivalence principle, to be conducted during the free fall portion of a sounding rocket flight. The test of a single pair of substances is aimed at a measurement uncertainty of sigma(eta) < 10^-16 after averaging the results of eight separate drops. The weak equivalence principle measurement is made with a set of four laser gauges that are expected to achieve 0.1 pm Hz^-1/2. The discovery of a violation (eta not equal to 0) would have profound implications for physics, astrophysics, and cosmology.

  20. Idiomaticity of English Business Terms and Their Equivalents in Lithuanian

    Directory of Open Access Journals (Sweden)

    Pavel Skorupa

    2011-04-01

    Full Text Available The paper presents the survey of idiomatic English business terms and their Lithuanian equivalents. The study was based on the theory of idioms and idiomaticity, highlighting the idea that idiomaticity can affect single words, word combinations, and longer text passages. Idiomatic business terms were taken from different English and Lithuanian general and special dictionaries, course books, as well as business texts. The analyzed terms were classified into distinct groups according to their meaning. The key problem encountered was the lack of Lithuanian translation equivalents to certain idiomatic English business terms. Possible Lithuanian translation was provided.

  1. Graphene-based THz modulator analyzed by equivalent circuit model

    DEFF Research Database (Denmark)

    Xiao, Binggang; Chen, Jing; Xie, Zhiyi

    2016-01-01

    A terahertz (THz) modulator based on graphene is proposed and analysed by use of equivalent transmission line of a homogeneous mediumand the local anisotropic model of the graphene conductivity. The result calculated by the equivalent circuit is consistent with that obtained byFresnel transfer...... matrices. For the modulator proposed here, when the frequency of carrier wave is 0.6 THz, the theoretical analysis indicatesthat the modulation bandwidth is 55.5 kHz and the modulation depth is 81.3% for voltage change from 0 to 50 V...

  2. Design of bent waveguide semiconductor lasers using nonlinear equivalent chirp

    Science.gov (United States)

    Li, Lianyan; Shi, Yuechun; Zhang, Yunshan; Chen, Xiangfei

    2018-01-01

    Reconstruction equivalent chirp (REC) technique is widely used in the design and fabrication of semiconductor laser arrays and tunable lasers with low cost and high wavelength accuracy. Bent waveguide is a promising method to suppress the zeroth order resonance, which is an intrinsic problem in REC technique. However, it may introduce basic grating chirp and deteriorate the single longitudinal mode (SLM) property of the laser. A nonlinear equivalent chirp pattern is proposed in this paper to compensate the grating chirp and improve the SLM property. It will benefit the realization of low-cost Distributed feedback (DFB) semiconductor laser arrays with accurate lasing wavelength.

  3. Radiobiological equivalent of low/high dose rate brachytherapy and evaluation of tumor and normal responses to the dose.

    Science.gov (United States)

    Manimaran, S

    2007-06-01

    The aim of this study was to compare the biological equivalent of low-dose-rate (LDR) and high-dose-rate (HDR) brachytherapy in terms of the more recent linear quadratic (LQ) model, which leads to theoretical estimation of biological equivalence. One of the key features of the LQ model is that it allows a more systematic radiobiological comparison between different types of treatment because the main parameters alpha/beta and micro are tissue-specific. Such comparisons also allow assessment of the likely change in the therapeutic ratio when switching between LDR and HDR treatments. The main application of LQ methodology, which focuses on by increasing the availability of remote afterloading units, has been to design fractionated HDR treatments that can replace existing LDR techniques. In this study, with LDR treatments (39 Gy in 48 h) equivalent to 11 fractions of HDR irradiation at the experimental level, there are increasing reports of reproducible animal models that may be used to investigate the biological basis of brachytherapy and to help confirm theoretical predictions. This is a timely development owing to the nonavailability of sufficient retrospective patient data analysis. It appears that HDR brachytherapy is likely to be a viable alternative to LDR only if it is delivered without a prohibitively large number of fractions (e.g., fewer than 11). With increased scientific understanding and technological capability, the prospect of a dose equivalent to HDR brachytherapy will allow greater utilization of the concepts discussed in this article.

  4. Bioactive equivalence of combinatorial components identified in screening of an herbal medicine.

    Science.gov (United States)

    Liu, Peng; Yang, Hua; Long, Fang; Hao, Hai-Ping; Xu, Xiaojun; Liu, Ying; Shi, Xiao-Wei; Zhang, Dan-Dan; Zheng, Hao-Chuan; Wen, Qian-Ying; Li, Wen-Wen; Ji, Hui; Jiang, Xi-Juan; Zhang, Bo-Li; Qi, Lian-Wen; Li, Ping

    2014-07-01

    To identify bioactive equivalent combinatorial components (BECCs) in herbal medicines. The exact composition of effective components in herbal medicines is often elusive due to the lack of adequate screening methodology. Herein, we propose a hypothesis that BECCs accounting for the whole efficacy of original herbal medicines could be discovered from a complex mixture of constituents. We developed a bioactive equivalence oriented feedback screening method and applied it to discover the BECCs from an herbal preparation Cardiotonic Pill (CP). The operations include chemical profiling of CP, followed by an iterative loop of determining, collecting and evaluating candidate BECCs. A combination of 18 compounds was identified as BECCs from CP, which accounts for 15.0% (w/w) of original CP. We have demonstrated that the BECCs were as effective as CP in cell models and in a rat model of myocardial infarction. This work answers the key question of which are real bioactive components for CP that have been used in clinic for many years, and provides a promising approach for discovering BECCs from herbal medicines. More importantly, the BECCs could be extended to improve quality control of herbal products and inspire an herbal medicines based discovery of combinatorial therapeutics.

  5. Purinergic Signalling: Therapeutic Developments

    Directory of Open Access Journals (Sweden)

    Geoffrey Burnstock

    2017-09-01

    Full Text Available Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and characterised, which includes four subtypes of the P1 (adenosine receptor, seven subtypes of P2X ion channel receptors and 8 subtypes of the P2Y G protein-coupled receptor. Early studies were largely concerned with the physiology, pharmacology and biochemistry of purinergic signalling. More recently, the focus has been on the pathophysiology and therapeutic potential. There was early recognition of the use of P1 receptor agonists for the treatment of supraventricular tachycardia and A2A receptor antagonists are promising for the treatment of Parkinson’s disease. Clopidogrel, a P2Y12 antagonist, is widely used for the treatment of thrombosis and stroke, blocking P2Y12 receptor-mediated platelet aggregation. Diquafosol, a long acting P2Y2 receptor agonist, is being used for the treatment of dry eye. P2X3 receptor antagonists have been developed that are orally bioavailable and stable in vivo and are currently in clinical trials for the treatment of chronic cough, bladder incontinence, visceral pain and hypertension. Antagonists to P2X7 receptors are being investigated for the treatment of inflammatory disorders, including neurodegenerative diseases. Other investigations are in progress for the use of purinergic agents for the treatment of osteoporosis, myocardial infarction, irritable bowel syndrome, epilepsy, atherosclerosis, depression, autism, diabetes, and cancer.

  6. Therapeutical aspect of trichomoniasis

    Directory of Open Access Journals (Sweden)

    Vukićević Jelica

    2003-01-01

    Full Text Available Trichomoniasis is frequent, parasitic and sexually transmitted infection of genitourinary tract. It is treated by metronidazole (5-nitroimidazole according to protocol recommended by Center for Disease Control (CDC formerly called: Communicable Disease Center [19]. The resistance of Trichomonas vaginalis (TV strains to metronidazole (MND was described in USA in 1960, and later on in many European countries [8, 9, 10, 11, 12, 13]. In these cases, due to persistent trichomonas infection, it is necessary to repeat MND treatment with moderate modification of dose and/or length of its application. Nevertheless, oncogenic and toxic effects of MND have to be taken into consideration. OBJECT The aim of this study was to investigate and analyze the incidence of TV in STD and lower susceptibility of certain TV strains to MND were analyzed. MATERIAL AND METHODS In three-year period (1999-2001 612 patients (244 females and 368 males suspected of STD were examined clinically and microbiologically at the Institute of Dermatovenereology in Belgrade. The patients detected for TV were treated according to CDC protocol. The affected were considered cured if there was no manifest clinical infection, and no TV verified by microbiological test. Results TV was isolated in 216 patients (35.29 % of all subjects. Trichomonas infection was found in 90 (36.88 % out of 244 tested females and in 126 (32.34 % of 368 males. Clinically manifested infection, with extensive urethral and vaginal secretion, was recorded in 161 patients, while the asymptomatic form was found in 55 subjects. This result indicates the predominance of manifested trichomonas infections (75.54 % of cases. The difference of distribution of clinical forms of trichomoniasis, in relation to sex, was not statistically significant (c2=0.854; p>0.05. The patients with verified trichomonas infection were treated by metronidazole according to CDC protocol. The recommended therapeutical scheme consisted of three

  7. READING PHILEMON AS THERAPEUTIC NARRATIVE

    African Journals Online (AJOL)

    2010-03-29

    Mar 29, 2010 ... Contrary to an initial impression, the narrative therapeutic approach does not emerge from a completely psychological ... Furthermore, a narrative therapeutic reading does not exist in a vacuum, therefore this investigation ..... converted to Christianity, Philemon supported other believers in various ways ...

  8. Evaluation of pharmaceutical and chemical equivalence of selected ...

    African Journals Online (AJOL)

    Personal

    brands of enteric coated slow release diclofenac sodium tablets. The brands were ... each other nor for the innovator brand to achieve the same therapeutic effects. Key words: Tablet .... validated by product regulatory body, the. National ...

  9. Placebo found equivalent to amoxicillin for treatment of acute bronchitis in Nairobi, Kenya: a triple blind, randomised, equivalence trial.

    Science.gov (United States)

    Nduba, V N; Mwachari, C W; Magaret, A S; Park, D R; Kigo, A; Hooton, T M; Cohen, C R

    2008-11-01

    Antibiotic treatment is not recommended for acute bronchitis in immunocompetent patients in industrialised countries. Whether these recommendations are relevant to the developing world and to immunocompromised patients is unknown. Randomised, triple blind, placebo controlled equivalence trial of amoxicillin compared with placebo in 660 adults presenting to two outpatient clinics in Nairobi, Kenya, with acute bronchitis but without evidence of chronic lung disease. The primary study end point was clinical cure, as defined by a >or=75% reduction in a validated Acute Bronchitis Severity Score by 14 days; analysis was by intention to treat with equivalence defined as acute bronchitis is unhelpful, even in populations with a high prevalence of HIV infection.

  10. Exact equivalent straight waveguide model for bent and twisted waveguides

    DEFF Research Database (Denmark)

    Shyroki, Dzmitry

    2008-01-01

    Exact equivalent straight waveguide representation is given for a waveguide of arbitrary curvature and torsion. No assumptions regarding refractive index contrast, isotropy of materials, or particular morphology in the waveguide cross section are made. This enables rigorous full-vector modeling o...

  11. Snow water equivalent modeling components in NewAge-JGrass

    Science.gov (United States)

    Formetta, G.; Kampf, S. K.; David, O.; Rigon, R.

    2014-05-01

    This paper presents a package of modified temperature-index-based snow water equivalent models as part of the hydrological modeling system NewAge-JGrass. Three temperature-based snow models are integrated into the NewAge-JGrass modeling system and use many of its components such as those for radiation balance (short wave radiation balance, SWRB), kriging (KRIGING), automatic calibration algorithms (particle swarm optimization) and tests of goodness of fit (NewAge-V), to build suitable modeling solutions (MS). Similarly to all the NewAge-JGrass components, the models can be executed both in raster and in vector mode. The simulation time step can be daily, hourly or sub-hourly, depending on user needs and availability of input data. The MS are applied on the Cache la Poudre River basin (CO, USA) using three test applications. First, daily snow water equivalent is simulated for three different measurement stations for two snow model formulations. Second, hourly snow water equivalent is simulated using all the three different snow model formulae. Finally, a raster mode application is performed to compute snow water equivalent maps for the whole Cache la Poudre Basin.

  12. On Borel equivalence relations related to self-adjoint operators

    DEFF Research Database (Denmark)

    Ando, Hiroshi; Matsuzawa, Yasumichi

    2015-01-01

    In a recent work, we initiated the study of Borel equivalence relations defined on the Polish space ${\\rm{SA}}(H)$ of self-adjoint operators on a Hilbert space $H$, focusing on the difference between bounded and unbounded operators. In this paper, we show how the difficulty of specifying...

  13. School Principals' Leadership Skills: Measurement Equivalence across Cultures

    Science.gov (United States)

    Da'as, Rima'a

    2017-01-01

    Despite substantial interest and research in measuring leader's skills, little is known about the measurement equivalence and mean differences in the scores measuring principals' skills (cognitive, interpersonal, strategic) across cultures (collectivism versus individualism). The aim of the present study was to assess measurement…

  14. 43 CFR 426.11 - Class 1 equivalency.

    Science.gov (United States)

    2010-10-01

    ... measured in terms of net income per acre (reflecting both productivity and costs of production). The... income will be determined by considering the disposable income accruing to the farm operator's labor... farm income will be the measure of productivity to establish equivalency factors reflecting the acreage...

  15. Equivalence properties for the Radon-Nikodym property types and ...

    African Journals Online (AJOL)

    We show that the types I- and II-Λ-Radon-Nikodym Property of Banach spaces on the one hand, and the I- and II-Λ-Complete Continuity Property on the other, are equivalent properties whenever Λ is an ordering subset of a discrete abelian group. Mathematics Subject Classification (2000): Primary 46E40, 46G10; ...

  16. STRICT CONVEXITY THROUGH EQUIVALENT NORMS IN SEPARABLES BANACH SPACES

    Directory of Open Access Journals (Sweden)

    Willy Zubiaga Vera

    2016-12-01

    Full Text Available Let E be a separable Banach space with norm || . ||. In the present work, the objective is to construct a norm || . ||1 that is equivalent to || . || in E, such that || . ||1 is strictly convex. In addition it is shown that its dual conjugate norm is also strictly convex.

  17. 46 CFR Appendix A to Part 154 - Equivalent Stress

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Equivalent Stress A Appendix A to Part 154 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES SAFETY STANDARDS FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Pt. 154, App. A Appendix A to Part 154...

  18. Modeling of multilayer piezoelectric transducers for echegraphic applications equivalent circuits

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, A.; Riera, E.; San Emeterio, J.L.; Sanz, P.T.

    1988-09-01

    In this paper, the main equivalent circuits of pulse-echo, single element, multilayer piezoelectric transducers, are analyzed. The analogy of matching layers with lossless transmission lines is described. Finally, using the KLM model, the effects of backing and matching layers on the bandwidth and impulse response is analyzed.

  19. Equivalent Circuit of a High Q Tunable PIFA

    DEFF Research Database (Denmark)

    Barrio, Samantha Caporal Del; Pelosi, Mauro; Franek, Ondrej

    2011-01-01

    This paper presents an Equivalent Circuit Model (ECM) for a high Quality factor (Q) tunable Planar Inverted F Antenna (PIFA). A PIFA is described and simulated with the Finite-Difference Time-Domain (FDTD) method. The resonance behavior of the proposed ECM is compared to the FDTD results and shows...

  20. Physicochemical equivalence of some brands of Nifedipine retard ...

    African Journals Online (AJOL)

    This research evaluated the physicochemical equivalence of some samples of Nifedipine 20 mg Retard Tablets available in Nigeria. Seven samples were randomly procured from various zones of the country and standard protocols applied to evaluate their tablet weight uniformity, dimensions, hardness, disintegration time, ...

  1. Synonymy in the translation equivalent paradigms of a standard ...

    African Journals Online (AJOL)

    The norm in current canonical translation dictionaries with Afrikaans and English as the treated language pair is an undiscriminated grouping of partially synonymous translation equivalents. These are separated by commas as sole markers of synonymy. Lexicographers should reject this practice and embrace the view that ...

  2. - Synonymy in the Translation Equivalent Paradigms of a Standard ...

    African Journals Online (AJOL)

    Synonymy in the Translation. Equivalent Paradigms of a. Standard Translation Dictionary*. Phillip Adriaan Louw, Department of Afrikaans and Dutch,. University of Stellenbosch, South Africa. Abstract: The norm in current canonical translation dictionaries with Afrikaans and English as the treated language pair is an ...

  3. Determination of Total Potency Equivalent Concentration (Tpec) of ...

    African Journals Online (AJOL)

    Determination of Total Potency Equivalent Concentration (Tpec) of Carcinogenic Polycyclic Aromatic Hydrocarbons (Cpahs) In Soils of Bodo-City. ... the application of Dispersion by Chemical Reaction Technology, should be deployed immediately in this area for total detoxification and decontamination of the area.

  4. Equivalent Circuit Modeling of a Rotary Piezoelectric Motor

    DEFF Research Database (Denmark)

    El, Ghouti N.; Helbo, Jan

    2000-01-01

    In this paper, an enhanced equivalent circuit model of a rotary traveling wave piezoelectric ultrasonic motor "shinsei type USR60" is derived. The modeling is performed on the basis of an empirical approach combined with the electrical network method and some simplification assumptions about...

  5. Chickadees fail standardized operant tests for octave equivalence.

    Science.gov (United States)

    Hoeschele, Marisa; Weisman, Ronald G; Guillette, Lauren M; Hahn, Allison H; Sturdy, Christopher B

    2013-07-01

    Octave equivalence occurs when an observer judges notes separated by a doubling in frequency perceptually similar. The octave appears to form the basis of pitch change in all human cultures and thus may be of biological origin. Previously, we developed a nonverbal operant conditioning test of octave generalization and transfer in humans. The results of this testing showed that humans with and without musical training perceive the octave relationship between pitches. Our goal in the current study was to determine whether black-capped chickadees, a North American songbird, perceive octave equivalence. We chose these chickadees because of their reliance on pitch in assessing conspecific vocalizations, our strong background knowledge on their pitch height perception (log-linear perception of frequency), and the phylogenetic disparity between them and humans. Compared to humans, songbirds are highly skilled at using pitch height perception to classify pitches into ranges, independent of the octave. Our results suggest that chickadees used that skill, rather than octave equivalence, to transfer the note-range discrimination from one octave to the next. In contrast, there is evidence that at least some mammals, including humans, do perceive octave equivalence.

  6. Equivalent Circuit Modeling of a Rotary Piezoelectric Motor

    DEFF Research Database (Denmark)

    El, Ghouti N.; Helbo, Jan

    2000-01-01

    In this paper, an enhanced equivalent circuit model of a rotary traveling wave piezoelectric ultrasonic motor "shinsei type USR60" is derived. The modeling is performed on the basis of an empirical approach combined with the electrical network method and some simplification assumptions about the ...

  7. Measurement model equivalence in web- and paper-based surveys ...

    African Journals Online (AJOL)

    The aim of this research is to investigate whether web-based and paper-based organisational climate surveys can be regarded as equivalent techniques of data collection. Due to the complex geographical placement of various units of the participating organisation and limited internet access, both paper-based and

  8. A simple proof of Bernstein-Lunts equivalence

    OpenAIRE

    Pandžić, Pavle

    2004-01-01

    We give an easy proof of the Bernstein-Lunts equivalence of ordinary and equivariant derived categories of Harish-Chandra modules. This proof requires no boundedness assumptions. In the appendix we collect some needed, but not completely standard facts from homological algebra.

  9. A computational theory for the learning of equivalence relations

    Directory of Open Access Journals (Sweden)

    Sergio E Lew

    2011-10-01

    Full Text Available Equivalence relations are logical entities that emerge concurrently with the development of language capabilities.In this work we propose a computational model that learns to build equivalence relations by learning simple conditional rules. The model includes visual areas, dopaminergic and noradrenergic structures as well as prefrontal and motor areas, each of them modeled as a group of continuous valued units that simulate clusters of real neurons. In the model, lateral interaction between neurons of visual structures and top-down modulation of prefrontal/premotor structures over the activity of neurons in visual structures are necessary conditions for learning the paradigm. In terms of the number of neurons and their interaction, we show that a minimal structural complexity is required for learning equivalence relations among conditioned stimuli. Paradoxically, the emergence of the equivalence relation drives a reduction in the number of neurons needed to maintain those previously specific stimulus-response learned rules, allowing an efficient use of neuronal resources.

  10. Equivalence of Symptom Dimensions in Females and Males with Autism

    Science.gov (United States)

    Frazier, Thomas W.; Hardan, Antonio Y.

    2017-01-01

    This study investigated equivalence of autism symptom domains in males and females with autism. Symptom data were obtained from 2643 children and adolescents with autism spectrum disorder (352 females, 2291 males; age range = 4-17 years) included in the Simons Simplex Collection. Items from the Social Responsiveness Scale and Autism Diagnostic…

  11. 21 CFR 558.315 - Levamisole hydrochloride (equivalent).

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Levamisole hydrochloride (equivalent). 558.315 Section 558.315 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES.... Treatment of the following gastrointestinal worms and lung worm infections; stomach worms (Haemonchus...

  12. Microcystin-LR equivalent concentrations in fish tissue during a ...

    African Journals Online (AJOL)

    The effects of a decomposing cyanobacteria bloom on water quality and the accumulation of microcystin-LR equivalent toxin in fish at Loskop Dam were studied in ... cells were observed, while the highest concentration (3.25 μg l−1), 3.25x higher than World Health Organization standard, was observed in the riverine zone.

  13. Typicality effects in contingency-shaped generalized equivalence classes.

    Science.gov (United States)

    Galizio, Mark; Stewart, Katherine L; Pilgrim, Carol

    2004-11-01

    Two experiments were conducted using match-to-sample methodologies in an effort to model lexical classes, which include both arbitrary and perceptual relations between class members. Training in both experiments used a one-to-many mapping procedure with nonsense syllables as samples and eight sets of abstract stimuli as comparisons. These abstract stimuli differed along a number of dimensions, four of which were critical to the experimenter-defined class membership. Stimuli in some comparison sets included only one of the class-defining features, but stimuli in other sets included two, three, or all four of the critical features. After mastery of the baseline training, three types of probe tests were conducted: symmetry, transitivity/equivalence, and novel probe tests in which the training nonsense syllables served as samples, and comparisons were novel abstract stimuli that included one or more of the class-defining features. Symmetry and transitivity/equivalence probe tests showed that the stimuli used in training became members of equivalence classes. The novel stimuli also became class members on the basis of inclusion of any of the critical features. Thus these probe tests revealed the formation of open-ended generalized equivalence classes. In addition, typicality effects were observed such that comparison sets with more critical features were learned with fewer errors, responded to more rapidly, and judged to be better exemplars of the class. Contingency-shaped stimulus classes established through a match-to-sample procedure thus show several important behavioral similarities to natural lexical categories.

  14. Probing Students' Ideas of the Principle of Equivalence

    Science.gov (United States)

    Bandyopadhyay, Atanu; Kumar, Arvind

    2011-01-01

    The principle of equivalence was the first vital clue to Einstein in his extension of special relativity to general relativity, the modern theory of gravitation. In this paper we investigate in some detail students' understanding of this principle in a variety of contexts, when they are undergoing an introductory course on general relativity. The…

  15. Problems of Equivalence in Shona- English Bilingual Dictionaries ...

    African Journals Online (AJOL)

    This article will discuss the problems of translation equivalents in Shona-English dictionaries where lexicographers will be dealing with divergent languages and cultures, traditional practices of lexicography and the absence of reliable corpora. Keywords: bilingual lexicography, corpus, culture, culture-bound, cultural gap, ...

  16. Equivalent Selection in Specialized e-Lexicography: A Case Study ...

    African Journals Online (AJOL)

    This paper follows suit and elaborates on the selection of Spanish equivalents in a particular dictionary project: the Diccionario Inglés–Español de Contabilidad, one of the Accounting dictionaries. This dictionary aims to satisfy the needs of translators (primary user group), accountants and financial experts (secondary user ...

  17. State space realizations and monomial equivalence for convolutional codes

    NARCIS (Netherlands)

    Gluesing-Luerssen, Heide; Schneider, Gert

    2007-01-01

    We will study convolutional codes with the help of state space realizations. It will be shown that two such minimal realizations belong to the same code if and only if they are equivalent under the full state feedback group. This result will be used in order to prove that two codes with positive

  18. On the Equivalence of Tank Trucks and General Purpose Trucks ...

    African Journals Online (AJOL)

    The purpose of this paper is to address the question of the equivalence of the three different kinds of articulated vehicles which are normally used in haulage as prelude to tackling the issue of representation in the various branches of road freight industry, and balance. The uses to which trucks are put, appear to be equal in ...

  19. Interaction Equivalency in an OER, MOOCs and Informal Learning Era

    Science.gov (United States)

    Miyazoe, Terumi; Anderson, Terry

    2013-01-01

    This theoretical paper attempts to clarify design issues that the field of education has encountered in the context of OER (Open Educational Resources), Massive Open Online Courses (MOOCs) and increased emphasis on informal learning, as examined through the lens of the Interaction Equivalency Theorem. An overview of the core concepts of the…

  20. functional equivalence and the new dutch translation project 1.

    African Journals Online (AJOL)

    In this article De Blois and Mewe demonstrate how functional-equivalent principles had been originally defined with regard to the Netherlands Bible Society's Nieuwe. Bijbelvertaling (New Bible Translation) and had to be redefined in light of the need for a better theoretical model. The model, outlined in the article, also ...

  1. Carbon footprint calculation model for the Mexican food equivalent system

    Directory of Open Access Journals (Sweden)

    Salvador Ruiz Cerrillo

    2017-06-01

    Full Text Available Introduction: the impact environment trough the anthropogenic action has been contributed to the fast production of greenhouse gases effect (GHG, a way to estimate the quantity of these substances is the carbon footprint (CF, nowadays it does not exist enough models for the calculation of food carbon footprint. Objective: the aim of this study was to design a calculation model for the measurement of the carbon footprint on the Mexican food equivalent system. Methods: it was about a retrospective study, a bibliographic review was made with original and review articles in different specialized researchers, there were included publications in English and Spanish, also published from 2000 to 2016. Results: a reference table was proposed for the food carbon footprint calculation on the Mexican food equivalent system trough the carbon intensity indicator, which is determined by the grams of emissions equivalents of carbon dioxide (CO2 in relation with the energetic contribution of each food equivalent. Conclusion: in a conclusion manner, estimating food carbon footprint is still a challenge, mean while the calculation models proposal is important to estimate the production of GHG trough a more sustainable food system.

  2. Crosscultural measurement equivalence of the Health Assessment Questionnaire II

    National Research Council Canada - National Science Library

    Oude Voshaar, Antonius H; Glas, Cornelis A.W; ten Klooster, Peter M; Taal, Erik; Wolfe, Frederick; van de Laar, Mart A F J

    2013-01-01

    ... established , nothing is currently known about its crosscultural measurement equivalence. However, PF scores are often pooled or compared across countries. It is important to verify that the observed score differences or similarities across cultures reflect true differences or similarities in PF levels rather than cultural bias. Traditionally, researche...

  3. On the Equivalent of "Kill" in Mandarin Chinese

    Science.gov (United States)

    Tai, James H-Y.; Chou, Jane Yang

    1975-01-01

    The purpose of this article is to show that "sha" and "sha-si" are not identical and that there is no perfect correspondence between either word in Chinese and "to kill" in English. It is suggested that the closest Chinese equivalent is "nong-si." (Author/RM)

  4. State-Dependent Implication and Equivalence in Quantum Logic

    Directory of Open Access Journals (Sweden)

    Fedor Herbut

    2012-01-01

    Full Text Available Ideal occurrence of an event (projector leads to the known change of a state (density operator into (the Lüders state. It is shown that two events and give the same Lüders state if and only if the equivalence relation is valid. This relation determines equivalence classes. The set of them and each class, are studied in detail. It is proved that the range projector of the Lüders state can be evaluated as , where denotes the greatest lower bound, and is the null projector of . State-dependent implication extends absolute implication (which, in turn, determines the entire structure of quantum logic. and are investigated in a closely related way to mutual benefit. Inherent in the preorder is the state-dependent equivalence , defining equivalence classes in a given Boolean subalgebra. The quotient set, in which the classes are the elements, has itself a partially ordered structure, and so has each class. In a complete Boolean subalgebra, both structures are complete lattices. Physical meanings are discussed.

  5. Reduced-load equivalence for queues with Gaussian input

    NARCIS (Netherlands)

    A.B. Dieker (Ton)

    2004-01-01

    textabstractIn this note, we consider a queue fed by a number of independent heterogeneous Gaussian sources. We study under what conditions a reduced load equivalence holds, i.e., when a subset of the sources becomes asymptotically dominant as the buffer size increases. For this, recent results on

  6. Equivalent refractive index of the human lens upon accommodative response

    NARCIS (Netherlands)

    Hermans, E.A.; Dubbelman, M.; van der Heijde, R.G.L.; Heethaar, R.M.

    2008-01-01

    PURPOSE.: To experimentally verify the suggestion of Gullstrand (1909), i.e., that the equivalent refractive index of the human lens increases with accommodation. METHODS.: The left eye of five subjects was focused on different accommodation stimuli, while the right eye was imaged with Scheimpflug

  7. Groups of Self-Equivalences and Related Topics

    CERN Document Server

    1990-01-01

    Since the subject of Groups of Self-Equivalences was first discussed in 1958 in a paper of Barcuss and Barratt, a good deal of progress has been achieved. This is reviewed in this volume, first by a long survey article and a presentation of 17 open problems together with a bibliography of the subject, and by a further 14 original research articles.

  8. Problems of Equivalence in Shona- English Bilingual Dictionaries

    African Journals Online (AJOL)

    rbr

    This article will discuss the problems of ... making and general problems encountered in the process of compiling mono- ..... boundness, this equivalence is not possible. The marimba is another instrument played by the Shona. This instrument is made of oblong blocks that are fitted onto a frame that has resonators such as.

  9. Clinical applications of therapeutic phlebotomy

    Directory of Open Access Journals (Sweden)

    Kim KH

    2016-07-01

    Full Text Available Kyung Hee Kim,1 Ki Young Oh,2 1Department of Laboratory Medicine, Gachon University Gil Medical Center, Incheon, 2Department of Physical Medicine and Rehabilitation, Soonchunhyang University, Cheonan Hospital, Cheonan, South Korea Abstract: Phlebotomy is the removal of blood from the body, and therapeutic phlebotomy is the preferred treatment for blood disorders in which the removal of red blood cells or serum iron is the most efficient method for managing the symptoms and complications. Therapeutic phlebotomy is currently indicated for the treatment of hemochromatosis, polycythemia vera, porphyria cutanea tarda, sickle cell disease, and nonalcoholic fatty liver disease with hyperferritinemia. This review discusses therapeutic phlebotomy and the related disorders and also offers guidelines for establishing a therapeutic phlebotomy program. Keywords: therapeutic phlebotomy, hemochromatosis, polycythemia vera, porphyria cutanea tarda, sickle cell disease, nonalcoholic fatty liver disease

  10. Rethinking Therapeutic Misconception in Biobanking

    DEFF Research Database (Denmark)

    Tupasela, Aaro; Snell, Karoliina; Cañada, Jose

    2017-01-01

    Some authors have noted that in biobank research participants may be guided by what is called therapeutic misconception, whereby participants attribute therapeutic intent to research procedures.This article argues that the notion of therapeutic misconception is increasingly less justified when...... evaluating biobanks. We present four examples taken from recent developments in biobanking to argue why the notion of therapeutic misconception is problematic in that biobanking practices are increasingly seeking to bridge research and treatment in diff erent ways. In this article we explore examples where...... underpinnings for the need to separate research and treatment, and thus the notion of therapeutic misconception in the fi rst place. We call this tension between research and treatment ambivalent research advancement to highlight the difficulties that various actors have in managing such shifts within...

  11. Equivalence principles, spacetime structure and the cosmic connection

    Science.gov (United States)

    Ni, Wei-Tou

    2016-03-01

    After reviewing the meaning of various equivalence principles and the structure of electrodynamics, we give a fairly detailed account of the construction of the light cone and a core metric from the equivalence principle for photons (no birefringence, no polarization rotation and no amplification/attenuation in propagation) in the framework of linear electrodynamics using cosmic connections/observations as empirical support. The cosmic nonbirefringent propagation of photons independent of energy and polarization verifies the Galileo Equivalence Principle (Universality of Propagation) for photons/electromagnetic wave packets in spacetime. This nonbirefringence constrains the spacetime constitutive tensor to high precision to a core metric form with an axion degree and a dilaton degree of freedom. Thus comes the metric with axion and dilation. Constraints on axion and dilaton from astrophysical/cosmic propagation are reviewed. Eötvös-type experiments, Hughes-Drever-type experiments, redshift experiments then constrain and tie this core metric to agree with the matter metric, and hence a unique physical metric and universality of metrology. We summarize these experiments and review how the Galileo equivalence principle constrains the Einstein Equivalence Principle (EEP) theoretically. In local physics this physical metric gives the Lorentz/Poincaré covariance. Understanding that the metric and EEP come from the vacuum as a medium of electrodynamics in the linear regime, efforts to actively look for potential effects beyond this linear scheme are warranted. We emphasize the importance of doing Eötvös-type experiments or other type experiments using polarized bodies/polarized particles. We review the theoretical progress on the issue of gyrogravitational ratio for fundamental particles and update the experimental progress on the measurements of possible long range/intermediate range spin-spin, spin-monopole and spin-cosmos interactions.

  12. Therapeutic hypothermia for acute stroke

    DEFF Research Database (Denmark)

    Olsen, Tom Skyhøj; Weber, Uno Jakob; Kammersgaard, Lars Peter

    2003-01-01

    Experimental evidence and clinical experience show that hypothermia protects the brain from damage during ischaemia. There is a growing hope that the prevention of fever in stroke will improve outcome and that hypothermia may be a therapeutic option for the treatment of stroke. Body temperature...... obvious therapeutic potential, hypothermia as a form of neuroprotection for stroke has been investigated in only a few very small studies. Therapeutic hypothermia is feasible in acute stroke but owing to serious side-effects--such as hypotension, cardiac arrhythmia, and pneumonia--it is still thought...

  13. Frontiers in nano-therapeutics

    CERN Document Server

    Tasnim, Nishat; Sai Krishna, Katla; Kalagara, Sudhakar; Narayan, Mahesh; Noveron, Juan C; Joddar, Binata

    2017-01-01

    This brief highlights recent research advances in the area of nano-therapeutics. Nanotechnology holds immense potential for application in a wide range of biological and engineering applications such as molecular sensors for disease diagnosis, therapeutic agents for the treatment of diseases, a vehicle for delivering therapeutics and imaging agents for theranostic applications, both in-vitro and in-vivo. The brief is grouped into the following sections namely, A) Discrete Nanosystems ; B) Anisotropic Nanoparticles; C) Nano-films/coated/layered and D) Nano-composites.

  14. [Therapeutic management of neurodermatitis atopica].

    Science.gov (United States)

    Kägi, M K

    1998-08-01

    The therapy of atopic dermatitis remains a challenge. The success of any therapeutic concept is based on a broad and early diagnostic approach which allows to rule out relevant provocation factors and allergens. During remission periods the regular use of a topical basic therapy consisting of drug-free emolients is recommended. Topical corticosteroids as well as systemic or local antimicrobial therapy and antihistamines are essential during periods of acute exacerbations. Although during the last years a great number of new therapeutic approaches have been published, data of most of these therapeutic modalities are not sufficient to allow an unrestricted use in all patients with atopic dermatitis.

  15. [Current Therapeutic Approaches to Sarcoidosis].

    Science.gov (United States)

    Pizarro, Carmen; Skowasch, Dirk; Grohé, Christian

    2017-01-01

    Sarcoidosis represents a non-caseating, granulomatous disorder of unknown aetiology whose clinical manifestation is heterogeneous and frequently multisystemic. The portion of patients needing systemic treatment varies: though many patients may undergo spontaneous remission, organ-threatening courses demand systemic therapy. Corticosteroids are the first-line treatment option; however, disease´s progression and/or major corticosteroid side effects may require second- and third-line therapeutics. A current stepwise therapeutic algorithm to sarcoidosis that characterizes additive and alternative therapeutic agents is given in the following review. © Georg Thieme Verlag KG Stuttgart · New York.

  16. Monte Carlo simulation of the neutron spectral fluence and dose equivalent for use in shielding a proton therapy vault

    Science.gov (United States)

    Zheng, Yuanshui; Newhauser, Wayne; Klein, Eric; Low, Daniel

    2014-01-01

    Neutron production is of principal concern when designing proton therapy vault shielding. Conventionally, neutron calculations are based on analytical methods, which do not accurately consider beam shaping components and nozzle shielding. The goal of this study was to calculate, using Monte Carlo modeling, the neutron spectral fluence and neutron dose equivalent generated by a realistic proton therapy nozzle and evaluate how these data could be used in shielding calculations. We modeled a contemporary passive scattering proton therapy nozzle in detail with the MCNPX simulation code. The neutron spectral fluence and dose equivalent at various locations in the treatment room were calculated and compared to those obtained from a thick iron target bombarded by parallel proton beams, the simplified geometry on which analytical methods are based. The neutron spectral fluence distributions were similar for both methods, with deeply penetrating high-energy neutrons (E > 10 MeV) being most prevalent along the beam central axis, and low-energy neutrons predominating the neutron spectral fluence in the lateral region. However, unlike the inverse square falloff used in conventional analytical methods, this study shows that the neutron dose equivalent per therapeutic dose in the treatment room decreased with distance approximately following a power law, with an exponent of about −1.63 in the lateral region and −1.73 in the downstream region. Based on the simulated data according to the detailed nozzle modeling, we developed an empirical equation to estimate the neutron dose equivalent at any location and distance in the treatment vault, e.g. for cases in which detailed Monte Carlo modeling is not feasible. We applied the simulated neutron spectral fluence and dose equivalent to a shielding calculation as an example. PMID:19887713

  17. Equivalence principle and quantum mechanics: quantum simulation with entangled photons.

    Science.gov (United States)

    Longhi, S

    2018-01-15

    Einstein's equivalence principle (EP) states the complete physical equivalence of a gravitational field and corresponding inertial field in an accelerated reference frame. However, to what extent the EP remains valid in non-relativistic quantum mechanics is a controversial issue. To avoid violation of the EP, Bargmann's superselection rule forbids a coherent superposition of states with different masses. Here we suggest a quantum simulation of non-relativistic Schrödinger particle dynamics in non-inertial reference frames, which is based on the propagation of polarization-entangled photon pairs in curved and birefringent optical waveguides and Hong-Ou-Mandel quantum interference measurement. The photonic simulator can emulate superposition of mass states, which would lead to violation of the EP.

  18. Markovian Testing Equivalence and Exponentially Timed Internal Actions

    Directory of Open Access Journals (Sweden)

    Marco Bernardo

    2009-12-01

    Full Text Available In the theory of testing for Markovian processes developed so far, exponentially timed internal actions are not admitted within processes. When present, these actions cannot be abstracted away, because their execution takes a nonzero amount of time and hence can be observed. On the other hand, they must be carefully taken into account, in order not to equate processes that are distinguishable from a timing viewpoint. In this paper, we recast the definition of Markovian testing equivalence in the framework of a Markovian process calculus including exponentially timed internal actions. Then, we show that the resulting behavioral equivalence is a congruence, has a sound and complete axiomatization, has a modal logic characterization, and can be decided in polynomial time.

  19. Global versus Local -- Mach's Principle versus the Equivalence Principle

    CERN Document Server

    Singleton, Douglas

    2016-01-01

    The equivalence principle is the conceptual basis for general relativity. In contrast Mach's principle, although said to have been influential on Einstein in his formulation of general relativity, has not been shown to be central to the structure of general relativity. In this essay we suggest that the quantum effects of Hawking and Unruh radiation are a manifestation of a {\\it thermal} Mach's principle, where the local thermodynamic properties of the system are determined by the non-local structure of the quantum fields which determine the vacuum of a given spacetime. By comparing Hawking and Unruh temperatures for the same local acceleration we find a violation of the Einstein elevator version of the equivalence principle, which vanishes in the limit that the horizon is approached.

  20. A new PK equivalence test for a bridging study.

    Science.gov (United States)

    Novick, Steven J; Zhang, Xiang; Yang, Harry

    2016-01-01

    In a bridging study, the plasma drug concentration-time curve is generally used to assess bioequivalence between the two formulations. Selected pharmacokinetic (PK) parameters including the area under the concentration-time curve, the maximum plasma concentration or peak exposure (Cmax), and drug half-life (T1/2) are compared to ensure comparable bioavailability of the two formulations. Comparability in these PK parameters, however, does not necessarily imply equivalence of the entire concentration-time profile. In this article, we propose an alternative metric of equivalence based on the maximum difference between PK profiles of the two formulations. A test procedure based on Bayesian analysis and accounting for uncertainties in model parameters is developed. Through both theoretical derivation and empirical simulation, it is shown that the new method provides better control over consumer's risk.

  1. Derivation of equivalent continuous dilution for cyclic, unsteady driving forces

    DEFF Research Database (Denmark)

    Sherman, Max H.; Mortensen, Dorthe Kragsig; Walker, Iain S.

    2011-01-01

    This article uses an analytical approach to determine the dilution of an unsteadily-generated solute in an unsteady solvent stream, under cyclic temporal boundary conditions. The goal is to find a simplified way of showing equivalence of such a process to a reference case where equivalent dilution...... is defined as a weighted average concentration. This derivation has direct applications to the ventilation of indoor spaces where indoor air quality and energy consumption cannot in general be simultaneously optimized. By solving the equation we can specify how much air we need to use in one ventilation...... pattern compared to another to obtain same indoor air quality. Because energy consumption is related to the amount of air exchanged by a ventilation system, the equation can be used as a first step to evaluate different ventilation patterns effect on the energy consumption. The use of the derived equation...

  2. Equivalent Pairs of Words and Points of Connection

    Directory of Open Access Journals (Sweden)

    Qaiser Mushtaq

    2014-01-01

    Full Text Available Higman has defined coset diagrams for PGL(2,Z. The coset diagrams are composed of fragments, and the fragments are further composed of two or more circuits. A condition for the existence of a certain fragment γ in a coset diagram is a polynomial f in Z[z], obtained by choosing a pair of words F[wi,wj] such that both wi and wj fix a vertex v in γ. Two pairs of words are equivalent if and only if they have the same polynomial. In this paper, we find distinct pairs of words that are equivalent. We also show there are certain fragments, which have the same orientations as those of their mirror images.

  3. Equivalent-Continuum Modeling of Nano-Structured Materials

    Science.gov (United States)

    Odegard, Gregory M.; Gates, Thomas S.; Nicholson, Lee M.; Wise, Kristopher E.

    2001-01-01

    A method has been developed for modeling structure-property relationships of nano-structured materials. This method serves as a link between computational chemistry and solid mechanics by substituting discrete molecular structures with an equivalent-continuum model. It has been shown that this substitution may be accomplished by equating the vibrational potential energy of a nano-structured material with the strain energy of representative truss and continuum models. As an important example with direct application to the development and characterization of single-walled carbon nanotubes, the model has been applied to determine the effective continuum geometry of a graphene sheet. A representative volume element of the equivalent-continuum model has been developed with an effective thickness. This effective thickness has been shown to be similar to, but slightly smaller than, the interatomic spacing of graphite.

  4. Negotiating for more: the multiple equivalent simultaneous offer.

    Science.gov (United States)

    Heller, Richard E

    2014-02-01

    Whether a doctor, professional baseball manager, or a politician, having successful negotiation skills is a critical part of being a leader. Building upon prior journal articles on negotiation strategy, the author presents the concept of the multiple equivalent simultaneous offer (MESO). The concept of a MESO is straightforward: as opposed to making a single offer, make multiple offers with several variables. Each offer alters the different variables, such that the end result of each offer is equivalent from the perspective of the party making the offer. Research has found several advantages to the use of MESOs. For example, using MESOs, an offer was more likely to be accepted, and the counterparty was more likely to be satisfied with the negotiated deal. Additional benefits have been documented as well, underscoring why a prepared radiology business leader should understand the theory and practice of MESO. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  5. Can quantum probes satisfy the weak equivalence principle?

    Energy Technology Data Exchange (ETDEWEB)

    Seveso, Luigi, E-mail: luigi.seveso@unimi.it [Quantum Technology Lab, Dipartimento di Fisica, Università degli Studi di Milano, I-20133 Milano (Italy); Paris, Matteo G.A. [Quantum Technology Lab, Dipartimento di Fisica, Università degli Studi di Milano, I-20133 Milano (Italy); INFN, Sezione di Milano, I-20133 Milano (Italy)

    2017-05-15

    We address the question whether quantum probes in a gravitational field can be considered as test particles obeying the weak equivalence principle (WEP). A formulation of the WEP is proposed which applies also in the quantum regime, while maintaining the physical content of its classical counterpart. Such formulation requires the introduction of a gravitational field not to modify the Fisher information about the mass of a freely-falling probe, extractable through measurements of its position. We discover that, while in a uniform field quantum probes satisfy our formulation of the WEP exactly, gravity gradients can encode nontrivial information about the particle’s mass in its wavefunction, leading to violations of the WEP. - Highlights: • Can quantum probes under gravity be approximated as test-bodies? • A formulation of the weak equivalence principle for quantum probes is proposed. • Quantum probes are found to violate it as a matter of principle.

  6. Matchgate and space-bounded quantum computations are equivalent

    OpenAIRE

    Jozsa, Richard; Kraus, Barbara; Miyake, Akimasa; Watrous, John

    2009-01-01

    Matchgates are an especially multiflorous class of two-qubit nearest neighbour quantum gates, defined by a set of algebraic constraints. They occur for example in the theory of perfect matchings of graphs, non-interacting fermions, and one-dimensional spin chains. We show that the computational power of circuits of matchgates is equivalent to that of space-bounded quantum computation with unitary gates, with space restricted to being logarithmic in the width of the matchgate circuit. In parti...

  7. Lack of energetic equivalence in forest soil invertebrates.

    Science.gov (United States)

    Ehnes, Roswitha B; Pollierer, Melanie M; Erdmann, Georgia; Klarner, Bernhard; Eitzinger, Bernhard; Digel, Christoph; Ott, David; Maraun, Mark; Scheu, Stefan; Brose, Ulrich

    2014-02-01

    Ecological communities consist of small abundant and large non-abundant species. The energetic equivalence rule is an often-observed pattern that could be explained by equal energy usage among abundant small organisms and non-abundant large organisms. To generate this pattern, metabolism (as an indicator of individual energy use) and abundance have to scale inversely with body mass, and cancel each other out. In contrast, the pattern referred to as biomass equivalence states that the biomass of all species in an area should be constant across the body-mass range. In this study, we investigated forest soil communities with respect to metabolism, abundance, population energy use, and biomass. We focused on four land-use types in three different landscape blocks (Biodiversity Exploratories). The soil samples contained 870 species across 12 phylogenetic groups. Our results indicated positive sublinear metabolic scaling and negative sublinear abundance scaling with species body mass. The relationships varied mainly due to differences among phylogenetic groups or feeding types, and only marginally due to land-use type. However, these scaling relationships were not exactly inverse to each other, resulting in increasing population energy use and biomass with increasing body mass for most combinations of phylogenetic group or feeding type with land-use type. Thus, our results are mostly inconsistent with the classic perception of energetic equivalence, and reject the biomass equivalence hypothesis while documenting a specific and nonrandom pattern of how abundance, energy use, and biomass are distributed across size classes. However, these patterns are consistent with two alternative predictions: the resource-thinning hypothesis, which states that abundance decreases with trophic level, and the allometric degree hypothesis, which states that population energy use should increase with population average body mass, due to correlations with the number of links of consumers and

  8. Dialogue on the Principle of Mass-Energy Equivalence

    OpenAIRE

    Ezzat G. Bakhoum

    2004-01-01

    This paper is directed to the readers who are familiar with the earlier papers by the author on the topic of mass-energy equivalence. A number of important questions about the total energy equation H=mv^2 and its implications are answered qualitatively. The relationship between the equation H=mv^2 and the 4-vector (Minkowski) representation of Special Relativity is discussed in detail. Other issues, such as de Broglie's original formulation of wave mechanics, are also discussed.

  9. Decentralized Pricing and the equivalence between Nash and Walrasian equilibrium

    OpenAIRE

    Mandel, Antoine; Gintis, Herbert

    2016-01-01

    International audience; We introduce, in the standard exchange economy model, market games in which agents use private prices as strategies. We give conditions on the game form that ensure that the only strict Nash equilibria of the game are the competitive equilibria of the underlying economy. This equivalence result has two main corollaries. First, it adds to the evidence that competitive equilibria can be strategically stable even in small economies. Second, it implies that competitive equ...

  10. Measurement model equivalence in web- and paper-based surveys

    African Journals Online (AJOL)

    Measurement model equivalence in web- and paper-based surveys. N. Martins. 4ABSTRACT. 8The aim of this research is to investigate whether web-based ... panels for survey research and found that the use of internet panels would continue to grow and that it would be ...... (q26–q29) and Teamwork (q93–q97). Items q17 ...

  11. Noise equivalent circuit of a semiconductor laser diode

    Science.gov (United States)

    Harder, C.; Margalit, S.; Yariv, A.; Katz, J.; Shacham, J.

    1982-01-01

    A small-signal model of a semiconductor laser is extended to include the effects of intrinsic noise by adding current and voltage noise sources. The current noise source represents the shot noise of carrier recombination, while the voltage noise source represents the random process of simulated emission. The usefulness of the noise equivalent circuit is demonstrated by calculating the modulation and noise characteristics of a current-driven diode as a function of bias current and frequency.

  12. Electric circuit networks equivalent to chaotic quantum billiards

    OpenAIRE

    Bulgakov, Evgeny N.; Maksimov, Dmitrii N.; Sadreev, Almas F.

    2004-01-01

    We formulate two types of electric RLC resonance network equivalent to quantum billiards. In the network of inductors grounded by capacitors squared resonant frequencies are eigenvalues of the quantum billiard. In the network of capacitors grounded by inductors squared resonant frequencies are given by inverse eigen values of the billiard. In both cases local voltages play role of the wave function of the quantum billiard. However as different from quantum billiards there is a heat power beca...

  13. Noise equivalent circuit of a semiconductor laser diode

    Science.gov (United States)

    Harder, C.; Margalit, S.; Yariv, A.; Katz, J.; Shacham, J.

    1982-03-01

    A small-signal model of a semiconductor laser is extended to include the effects of intrinsic noise by adding current and voltage noise sources. The current noise source represents the shot noise of carrier recombination, while the voltage noise source represents the random process of simulated emission. The usefulness of the noise equivalent circuit is demonstrated by calculating the modulation and noise characteristics of a current-driven diode as a function of bias current and frequency.

  14. Equivalence of Conventional and Modified Network of Generalized Neural Elements

    Directory of Open Access Journals (Sweden)

    E. V. Konovalov

    2016-01-01

    Full Text Available The article is devoted to the analysis of neural networks consisting of generalized neural elements. The first part of the article proposes a new neural network model — a modified network of generalized neural elements (MGNE-network. This network developes the model of generalized neural element, whose formal description contains some flaws. In the model of the MGNE-network these drawbacks are overcome. A neural network is introduced all at once, without preliminary description of the model of a single neural element and method of such elements interaction. The description of neural network mathematical model is simplified and makes it relatively easy to construct on its basis a simulation model to conduct numerical experiments. The model of the MGNE-network is universal, uniting properties of networks consisting of neurons-oscillators and neurons-detectors. In the second part of the article we prove the equivalence of the dynamics of the two considered neural networks: the network, consisting of classical generalized neural elements, and MGNE-network. We introduce the definition of equivalence in the functioning of the generalized neural element and the MGNE-network consisting of a single element. Then we introduce the definition of the equivalence of the dynamics of the two neural networks in general. It is determined the correlation of different parameters of the two considered neural network models. We discuss the issue of matching the initial conditions of the two considered neural network models. We prove the theorem about the equivalence of the dynamics of the two considered neural networks. This theorem allows us to apply all previously obtained results for the networks, consisting of classical generalized neural elements, to the MGNE-network.

  15. FORWARDER DEPRICIATION ANALYSIS APPLIED TO EQUIVALENT UNIFORM ANNUAL COST

    OpenAIRE

    DANILO SIMÕES; RICARDO GHANTOUS CERVI; PAULO TORRES FENNER

    2013-01-01

    Depreciation is considered a necessary fixed cost to replace a machinery or goods at the end of its useful life thus interfering directly on the Equivalent Annual Cost (EAC). This paper aimed at analyzing different methods used to calculate depreciation over the useful economic life of a Forwarder, a machine used in eucalyptus harvesting process, evaluating the influence of such methods in estimating EAC. Five depreciation methods were evaluated: Straight-line, Declining Balanc...

  16. The Equivalence of Two Constructions of Galton-Watson Processes

    CERN Document Server

    Kurata, K

    2004-01-01

    In most textbooks on branching processes, the Galton-Watson process is defined as an integer valued Markov chain with a special kind of transition probability, somtimes supplemented with an intuitive description of random family trees. A precise construction of the Galton-Watson process on the space of trees was first given by R. Otter in 1949, and later independently by J. Neveu in 1986. In this note, we show that these two constructions are actually equivalent.

  17. Modelling of Airship Flight Mechanics by the Projection Equivalent Method

    OpenAIRE

    Frantisek Jelenciak; Michael Gerke; Ulrich Borgolte

    2015-01-01

    This article describes the projection equivalent method (PEM) as a specific and relatively simple approach for the modelling of aircraft dynamics. By the PEM it is possible to obtain a mathematic al model of the aerodynamic forces and momentums acting on different kinds of aircraft during flight. For the PEM, it is a characteristic of it that - in principle - it provides an acceptable regression model of aerodynamic forces and momentums which exhibits reasonable and plausible behaviour from a...

  18. Nineteenth-Century Measurements of the Mechanical Equivalent of Heat

    Science.gov (United States)

    Greenslade, Thomas B.

    2002-04-01

    Today the measurement of the mechanical equivalent of heat is a laboratory exercise in which the student tries to come close to the accepted value. How different was the attitude of the 19th-century physicists and engineers, for which the value was a key link between mechanics and thermodynamics, two seemingly separate domains of physics. This article discusses some of the pioneering experiments, translating them into modern nomenclature and units.

  19. Water-equivalent fiber radiation dosimeter with two scintillating materials

    OpenAIRE

    Qin, Zhuang; Hu, Yaosheng; Ma, Yu; Lin, Wei; Luo, Xianping; Zhao, Wenhui; Sun, Weimin; Zhang, Daxin; Chen, Ziyin; Wang, Boran; Lewis, Elfed

    2016-01-01

    An inorganic scintillating material plastic optical fiber (POF) dosimeter for measuring ionizing radiation during radiotherapy applications is reported. It is necessary that an ideal dosimeter exhibits many desirable qualities, including water equivalence, energy independence, reproducibility, dose linearity. There has been much recent research concerning inorganic dosimeters. However, little reference has been made to date of the depth-dose characteristics of dosimeter materials. In the case...

  20. On equivalent expressions for the Faraday's law of induction

    OpenAIRE

    Rodrigues,Fabio G.

    2012-01-01

    In this paper we give a rigorous proof of the equivalence of some different forms of Faraday's law of induction clarifying some misconceptions on the subject and emphasizing that many derivations of this law appearing in textbooks and papers are only valid under very special circunstances, thus are not satisfactory under a mathematical point of view. We show also that Faraday's law of induction is a relativistic invariant law in a very precise mathematical sense.

  1. On Equivalent Expressions for the Faraday's Law of Induction

    OpenAIRE

    Rodrigues, Fabio G.

    2010-01-01

    In this paper we give a rigorous proof of the equivalence of some different forms of Faraday's law of induction clarifying some misconceptions on the subject and emphasizing that many derivations of this law appearing in textbooks and papers are only valid under very special circunstances, thus are not satisfactory under a mathematical point of view. We show also that Faraday's law of induction is a relativistic invariant law in a very precise mathematical sense. Neste trabalho e dada uma ...

  2. Codes over infinite family of rings : Equivalence and invariant ring

    Science.gov (United States)

    Irwansyah, Muchtadi-Alamsyah, Intan; Muchlis, Ahmad; Barra, Aleams; Suprijanto, Djoko

    2016-02-01

    In this paper, we study codes over the ring Bk=𝔽pr[v1,…,vk]/(vi2=vi,∀i =1 ,…,k ) . For instance, we focus on two topics, i.e. characterization of the equivalent condition between two codes over Bk using a Gray map into codes over finite field 𝔽pr, and finding generators for invariant ring of Hamming weight enumerator for Euclidean self-dual codes over Bk.

  3. Usage of attenuation coefficients of some tissue-equivalent materials

    OpenAIRE

    TANIR, Ayşe Güneş; KETENCİ, Fatma Serap; BÖLÜKDEMİR, Mustafa Hicabi

    2015-01-01

    The total attenuation coefficients of 11 biological targets against photon energies were plotted within the energy range 1-10 MeV. From these plots a possible equation describing the relationship between photon energy and the total attenuation coefficient was derived. The suggested equation is mu/ rho = 0.0696/ surd E. To test the validity of the equation and to compare the results of the total attenuation coefficients of 3 tissue-equivalent materials (bolus, rice grains, and boiled rice) th...

  4. [Therapeutic drug monitoring of antimicrobials

    NARCIS (Netherlands)

    Mouton, J.W.; Aarnoutse, R.E.

    2014-01-01

    The importance of dose adjustments of antimicrobials based on measured concentrations in an individual ('therapeutic drug monitoring', TDM) is increasingly recognized. There are several reasons for this. First, there is a better understanding of the relationships between doses administered,

  5. Equivalent plate modeling for conceptual design of aircraft wing structures

    Science.gov (United States)

    Giles, Gary L.

    1995-01-01

    This paper describes an analysis method that generates conceptual-level design data for aircraft wing structures. A key requirement is that this data must be produced in a timely manner so that is can be used effectively by multidisciplinary synthesis codes for performing systems studies. Such a capability is being developed by enhancing an equivalent plate structural analysis computer code to provide a more comprehensive, robust and user-friendly analysis tool. The paper focuses on recent enhancements to the Equivalent Laminated Plate Solution (ELAPS) analysis code that significantly expands the modeling capability and improves the accuracy of results. Modeling additions include use of out-of-plane plate segments for representing winglets and advanced wing concepts such as C-wings along with a new capability for modeling the internal rib and spar structure. The accuracy of calculated results is improved by including transverse shear effects in the formulation and by using multiple sets of assumed displacement functions in the analysis. Typical results are presented to demonstrate these new features. Example configurations include a C-wing transport aircraft, a representative fighter wing and a blended-wing-body transport. These applications are intended to demonstrate and quantify the benefits of using equivalent plate modeling of wing structures during conceptual design.

  6. Modeling Stochastic Route Choice Behaviors with Equivalent Impedance

    Directory of Open Access Journals (Sweden)

    Jun Li

    2015-01-01

    Full Text Available A Logit-based route choice model is proposed to address the overlapping and scaling problems in the traditional multinomial Logit model. The nonoverlapping links are defined as a subnetwork, and its equivalent impedance is explicitly calculated in order to simply network analyzing. The overlapping links are repeatedly merged into subnetworks with Logit-based equivalent travel costs. The choice set at each intersection comprises only the virtual equivalent route without overlapping. In order to capture heterogeneity in perception errors of different sizes of networks, different scale parameters are assigned to subnetworks and they are linked to the topological relationships to avoid estimation burden. The proposed model provides an alternative method to model the stochastic route choice behaviors without the overlapping and scaling problems, and it still maintains the simple and closed-form expression from the MNL model. A link-based loading algorithm based on Dial’s algorithm is proposed to obviate route enumeration and it is suitable to be applied on large-scale networks. Finally a comparison between the proposed model and other route choice models is given by numerical examples.

  7. The impact of sunlight on high-latitude equivalent currents

    CERN Document Server

    Laundal, K M; Østgaard, N; Reistad, J P; Haaland, S; Snekvik, K; Tenfjord, P; Ohtani, S; Milan, S E

    2016-01-01

    Ground magnetic field measurements can be mathematically related to an overhead ionospheric equivalent current. In this study we look in detail at how the global equivalent current, calculated using more than 30 years of SuperMAG magnetometer data, changes with sunlight conditions. The calculations are done using spherical harmonic analysis in quasi-dipole coordinates, a technique which leads to improved accuracy compared to previous studies. Sorting the data according to the location of the sunlight terminator and orientation of the interplanetary magnetic field (IMF), we find that the equivalent current resembles ionospheric convection patterns on the sunlit side of the terminator but not on the dark side. On the dark side, with southward IMF, the current is strongly dominated by a dawn cell and the current across the polar cap has a strong dawnward component. The contrast between the sunlit and dark side increases with increasing values of the $\\mathit{F}_{10.7}$ index, showing that increasing solar EUV fl...

  8. Functional equivalence of morphologies enables morphological and ecological diversity.

    Science.gov (United States)

    Young, Rebecca L; Haselkorn, Tamara S; Badyaev, Alexander V

    2007-11-01

    Diversity in organismal forms among taxa is thought to reflect distinct selection pressures across environments. The central assumption underlying this expectation is that taxa experiencing similar selection have similar response to that selection. However, because selection acts on trait function, taxa similarity in selection response depends crucially on the relationship between function and morphology. Further, when a trait consists of multiple parts, changes in function in response to selection can result from modification of different parts, and adaptation to the same environment might result in functional but not morphological similarity. Here, we address the extent to which functional and morphological diversity in masticatory apparatus of soricid shrews reflects a shared ecological characteristic of their diet type. We examine the factors limiting morphological variation across shrew species by assessing the relative contribution of trait function (biomechanics of the jaw), ecology, and phylogeny to species similarity in mandibular traits. We found that species that shared diet type were functionally but not morphologically similar. The presence of multiple semi-independently varying traits enabled functional equivalence of composite foraging morphologies and resulted in variable response to selection exerted by similar diet. We show that functional equivalence of multiple morphologies enabled persistence of differences in habitat use (e.g., habitat moisture and coverage) among species that specialize on the same diet. We discuss the importance of developmental and functional integration among traits for evolutionary diversification of morphological structures that generate equivalent functions.

  9. Therapeutic Vaccines for Chronic Infections

    Science.gov (United States)

    Autran, Brigitte; Carcelain, Guislaine; Combadiere, Béhazine; Debre, Patrice

    2004-07-01

    Therapeutic vaccines aim to prevent severe complications of a chronic infection by reinforcing host defenses when some immune control, albeit insufficient, can already be demonstrated and when a conventional antimicrobial therapy either is not available or has limited efficacy. We focus on the rationale and challenges behind this still controversial strategy and provide examples from three major chronic infectious diseases-human immunodeficiency virus, hepatitis B virus, and human papillomavirus-for which the efficacy of therapeutic vaccines is currently being evaluated.

  10. Investigation of radiological properties and water equivalency of PRESAGE dosimeters.

    Science.gov (United States)

    Gorjiara, Tina; Hill, Robin; Kuncic, Zdenka; Adamovics, John; Bosi, Stephen; Kim, Jung-Ha; Baldock, Clive

    2011-04-01

    PRESAGE is a dosimeter made of polyurethane, which is suitable for 3D dosimetry in modern radiation treatment techniques. Since an ideal dosimeter is radiologically water equivalent, the authors investigated water equivalency and the radiological properties of three different PRESAGE formulations that differ primarily in their elemental compositions. Two of the formulations are new and have lower halogen content than the original formulation. The radiological water equivalence was assessed by comparing the densities, interaction probabilities, and radiation dosimetry properties of the three different PRESAGE formulations to the corresponding values for water. The relative depth doses were calculated using Monte Carlo methods for 50, 100, 200, and 350 kVp and 6 MV x-ray beams. The mass densities of the three PRESAGE formulations varied from 5.3% higher than that of water to as much as 10% higher than that of water for the original formulation. The probability of photoelectric absorption in the three different PRESAGE formulations varied from 2.2 times greater than that of water for the new formulations to 3.5 times greater than that of water for the original formulation. The mass attenuation coefficient for the three formulations is 12%-50% higher than the value for water. These differences occur over an energy range (10-100 keV) in which the photoelectric effect is the dominant interaction. The collision mass stopping powers of the relatively lower halogen-containing PRESAGE formulations also exhibit marginally better water equivalency than the original higher halogen-containing PRESAGE formulation. Furthermore, the depth dose curves for the lower halogen-containing PRESAGE formulations are slightly closer to that of water for a 6 MV beam. In the kilovoltage energy range, the depth dose curves for the lower halogen-containing PRESAGE formulations are in better agreement with water than the original PRESAGE formulation. Based on the results of this study, the new

  11. Integrating hydraulic equivalent sections into a hydraulic geometry study

    Science.gov (United States)

    Jia, Yanhong; Yi, Yujun; Li, Zhiwei; Wang, Zhaoyin; Zheng, Xiangmin

    2017-09-01

    Hydraulic geometry (HG) is an important geomorphic concept that has played an indispensable role in hydrological analyses, physical studies of streams, ecosystem and aquatic habitat studies, and sedimentology research. More than 60 years after Leopold and Maddock (1953) first introduced the concept of HG, researchers have still not uncovered the physical principles underlying HG behavior. One impediment is the complexity of the natural river cross section. The current study presents a new way to simplify the cross section, namely, the hydraulic equivalent section, which is generalized from the cross section in the "gradually varied flow of an alluvial river" (GVFAR) and features hydrodynamic properties and bed-building laws similar to those of the GVFAR. Energy balance was used to derive the stage Z-discharge Q relationship in the GVFAR. The GVFAR in the Songhua River and the Yangtze River were selected as examples. The data, including measured discharge, river width, water stage, water depth, wet area, and cross section, were collected from the hydrological yearbooks of typical hydrological stations on the Songhua River and the Yangtze River from 1955 to 1987. The relationships between stage Z-discharge Q and cross-sectional area A-stage Z at various stations were analyzed, and "at-a-station hydraulic geometry" (AHG) relationships were obtained in power-law forms. Based on derived results and observational data analysis, the Z-Q and Z-A relationships of AHG were similar to rectangular weir flows, thus the cross section of the GVFAR was generalized as a compound rectangular, hydraulic equivalent cross section. As to bed-building characteristics, the bankfull discharge method and the stage-discharge-relation method were used to calculate the dominant variables of the alluvial river. This hydraulic equivalent section has the same Z-Q relation, Z-A relation, dominant discharge, dominant river width, and dominant water depth as the cross section in the GVFAR. With the

  12. Quantile equivalence to evaluate compliance with habitat management objectives

    Science.gov (United States)

    Cade, Brian S.; Johnson, Pamela R.

    2011-01-01

    Equivalence estimated with linear quantile regression was used to evaluate compliance with habitat management objectives at Arapaho National Wildlife Refuge based on monitoring data collected in upland (5,781 ha; n = 511 transects) and riparian and meadow (2,856 ha, n = 389 transects) habitats from 2005 to 2008. Quantiles were used because the management objectives specified proportions of the habitat area that needed to comply with vegetation criteria. The linear model was used to obtain estimates that were averaged across 4 y. The equivalence testing framework allowed us to interpret confidence intervals for estimated proportions with respect to intervals of vegetative criteria (equivalence regions) in either a liberal, benefit-of-doubt or conservative, fail-safe approach associated with minimizing alternative risks. Simple Boolean conditional arguments were used to combine the quantile equivalence results for individual vegetation components into a joint statement for the multivariable management objectives. For example, management objective 2A required at least 809 ha of upland habitat with a shrub composition ≥0.70 sagebrush (Artemisia spp.), 20–30% canopy cover of sagebrush ≥25 cm in height, ≥20% canopy cover of grasses, and ≥10% canopy cover of forbs on average over 4 y. Shrub composition and canopy cover of grass each were readily met on >3,000 ha under either conservative or liberal interpretations of sampling variability. However, there were only 809–1,214 ha (conservative to liberal) with ≥10% forb canopy cover and 405–1,098 ha with 20–30%canopy cover of sagebrush ≥25 cm in height. Only 91–180 ha of uplands simultaneously met criteria for all four components, primarily because canopy cover of sagebrush and forbs was inversely related when considered at the spatial scale (30 m) of a sample transect. We demonstrate how the quantile equivalence analyses also can help refine the numerical specification of habitat objectives and explore

  13. 10 CFR 474.3 - Petroleum-equivalent fuel economy calculation.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Petroleum-equivalent fuel economy calculation. 474.3..., DEVELOPMENT, AND DEMONSTRATION PROGRAM; PETROLEUM-EQUIVALENT FUEL ECONOMY CALCULATION § 474.3 Petroleum-equivalent fuel economy calculation. (a) The petroleum-equivalent fuel economy for an electric vehicle is...

  14. Equivalence of optical and electrical noise equivalent power of hybrid NbTiN-Al microwave kinetic inductance detectors

    Energy Technology Data Exchange (ETDEWEB)

    Janssen, R. M. J., E-mail: r.m.j.janssen@tudelft.nl [Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628CJ Delft (Netherlands); Endo, A. [Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628CJ Delft (Netherlands); Department of Microelectronics, Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), Delft University of Technology, Mekelweg 4, 2628 CD Delft (Netherlands); Visser, P. J. de [Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628CJ Delft (Netherlands); SRON Netherlands Institute for Space Research, Sorbonnelaan 2, 3584CA Utrecht (Netherlands); Klapwijk, T. M. [Kavli Institute of Nanoscience, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628CJ Delft (Netherlands); Physics Department, Moscow State Pedagogical University, Moscow 119991 (Russian Federation); Baselmans, J. J. A. [SRON Netherlands Institute for Space Research, Sorbonnelaan 2, 3584CA Utrecht (Netherlands)

    2014-11-10

    We have measured and compared the response of hybrid NbTiN-Al Microwave Kinetic Inductance Detectors (MKIDs) to changes in bath temperature and illumination by sub-mm radiation. We show that these two stimulants have an equivalent effect on the resonance feature of hybrid MKIDs. We determine an electrical noise equivalent power (NEP) from the measured temperature responsivity, quasiparticle recombination time, superconducting transition temperature, and noise spectrum, all of which can be measured in a dark environment. For the two hybrid NbTiN-Al MKIDs studied in detail, the electrical NEP is within a factor of two of the optical NEP, which is measured directly using a blackbody source.

  15. Nine equivalents of nursing manpower use score (NEMS)

    NARCIS (Netherlands)

    Miranda, DR; Moreno, R; Iapichino, G

    Objectives:To develop a simplified Therapeutic Intervention Scoring System (TISS) based on the TISS-28 items and to validate the new score in an independent dat abase. Design: Retrospective statistical analysis of a database and a prospective multicentre study. Setting: Development in the data base

  16. Impact on Bacterial Resistance of Therapeutically Nonequivalent Generics: The Case of Piperacillin-Tazobactam.

    Directory of Open Access Journals (Sweden)

    Carlos A Rodriguez

    Full Text Available Previous studies have demonstrated that pharmaceutical equivalence and pharmacokinetic equivalence of generic antibiotics are necessary but not sufficient conditions to guarantee therapeutic equivalence (better called pharmacodynamic equivalence. In addition, there is scientific evidence suggesting a direct link between pharmacodynamic nonequivalence of generic vancomycin and promotion of resistance in Staphylococcus aureus. To find out if even subtle deviations from the expected pharmacodynamic behavior with respect to the innovator could favor resistance, we studied a generic product of piperacillin-tazobactam characterized by pharmaceutical and pharmacokinetic equivalence but a faulty fit of Hill's Emax sigmoid model that could be interpreted as pharmacodynamic nonequivalence. We determined the impact in vivo of this generic product on the resistance of a mixed Escherichia coli population composed of ∼99% susceptible cells (ATCC 35218 strain and a ∼1% isogenic resistant subpopulation that overproduces TEM-1 β-lactamase. After only 24 hours of treatment in the neutropenic murine thigh infection model, the generic amplified the resistant subpopulation up to 20-times compared with the innovator, following an inverted-U dose-response relationship. These findings highlight the critical role of therapeutic nonequivalence of generic antibiotics as a key factor contributing to the global problem of bacterial resistance.

  17. Impact on Bacterial Resistance of Therapeutically Nonequivalent Generics: The Case of Piperacillin-Tazobactam.

    Science.gov (United States)

    Rodriguez, Carlos A; Agudelo, Maria; Aguilar, Yudy A; Zuluaga, Andres F; Vesga, Omar

    2016-01-01

    Previous studies have demonstrated that pharmaceutical equivalence and pharmacokinetic equivalence of generic antibiotics are necessary but not sufficient conditions to guarantee therapeutic equivalence (better called pharmacodynamic equivalence). In addition, there is scientific evidence suggesting a direct link between pharmacodynamic nonequivalence of generic vancomycin and promotion of resistance in Staphylococcus aureus. To find out if even subtle deviations from the expected pharmacodynamic behavior with respect to the innovator could favor resistance, we studied a generic product of piperacillin-tazobactam characterized by pharmaceutical and pharmacokinetic equivalence but a faulty fit of Hill's Emax sigmoid model that could be interpreted as pharmacodynamic nonequivalence. We determined the impact in vivo of this generic product on the resistance of a mixed Escherichia coli population composed of ∼99% susceptible cells (ATCC 35218 strain) and a ∼1% isogenic resistant subpopulation that overproduces TEM-1 β-lactamase. After only 24 hours of treatment in the neutropenic murine thigh infection model, the generic amplified the resistant subpopulation up to 20-times compared with the innovator, following an inverted-U dose-response relationship. These findings highlight the critical role of therapeutic nonequivalence of generic antibiotics as a key factor contributing to the global problem of bacterial resistance.

  18. Pharmaceutical equivalence of gabapentin tablets with various extragranular binders Pharmaceutical equivalence of gabapentin tablets with various extragranular binders

    Directory of Open Access Journals (Sweden)

    SWATI C. JAGDALE

    2010-06-01

    Full Text Available Gabapentin is a high-dose drug widely used as an oral anti-epilepticagent. Due to high crystalline and has poor compaction properties it is difficult to form tablets by direct compression. The aim of this study was to develop gabapentin tablets, pharmaceutically equivalent to the reference product Neurontin (marketed in USA. Gabapentin 800mg tablets were produced by wet granulation by keeping intragranular binder as well as its concentration constant and by changing with various extragranular binders with its concentration (A = PVPK 30, B = HPMC 15 cps, C = Kollidon VA 64, D =Klucel EXF.The tablet having no weight, thickness and hardness variation and having appropriate, friability as well as disintegration profile were coated with a 3% film coating solution .Seven formulations F1 (A in lower concentration F2 (A in higher concentration, F3 (B in lower concentration and F4 (B in higher concentration, F5 (C in lower concentration, F6 (C in higher concentration, F7 (D in lower concentration were formulated. Among them F6 demonstrated adequate hardness, friability, disintegration, uniformity of content, and total drug dissolution after 45minutes. The dissimilarity factor (f1 is 5.93 and the similarity factor (f2 is 67.85. So F6 was found to be equivalent to Neurontin.Gabapentin is widely used as an oral anti-epileptic agent. However, owing to its high crystallinity and poor compaction properties, it is difficult to form tablets of this drug by direct compression. The aim of this study was to develop gabapentin tablets, pharmaceutically equivalent to the brand-name pioneer product Neurontin® (marketed in USA. Gabapentin 800mg tablets were produced by wet granulation with a constant concentration of intragranular binder and a varying concentration of extragranular binders (A = polyvinylpyrrolidone K30, B = hydroxypropylmethylcellulose 15 cps, C = Kollidon VA64, D =Klucel EXF. The tablets that did not vary in weight, thickness or hardness and had

  19. Ecological equivalency as a tool for endangered species management.

    Science.gov (United States)

    Searcy, Christopher A; Rollins, Hilary B; Shaffer, H Bradley

    2016-01-01

    The use of taxon substitutes for extinct or endangered species is a controversial conservation measure. We use the example of the endangered California tiger salamander (Ambystoma californiense; CTS), which is being replaced by hybrids with the invasive barred tiger salamander (Ambystoma mavortium), to illustrate a strategy for evaluating taxon substitutes based on their position in a multivariate community space. Approximately one-quarter of CTS's range is currently occupied by "full hybrids" with 70% nonnative genes, while another one-quarter is occupied by "superinvasives" where a specific set of 3/68 genes comprising 4% of the surveyed genome is nonnative. Based on previous surveys of natural CTS breeding ponds, we stocked experimental mesocosms with field-verified, realistic densities of tiger salamander larvae and their prey, and used these mesocosms to evaluate ecological equivalency between pure CTS, full hybrids, and superinvasives in experimental pond communities. We also included a fourth treatment with no salamanders present to evaluate the community effects of eliminating Ambystoma larvae altogether. We found that pure CTS and superinvasive larvae were ecologically equivalent, because their positions in the multivariate community space were statistically indistinguishable and they did not differ significantly along any univariate community axes. Full hybrids were ecologically similar, but not equivalent, to the other two genotypes, and the no-Ambystoma treatment was by far the most divergent. We conclude that, at least for the larval stage, superinvasives are adequate taxon substitutes for pure CTS and should probably be afforded protection under the Endangered Species Act. The proper conservation status for full hybrids remains debatable.

  20. Pharmaceutical equivalence of metformin tablets with various binders

    Directory of Open Access Journals (Sweden)

    L. C. Block

    2009-01-01

    Full Text Available

    Metformin hydrochloride is a high-dose drug widely used as an oral anti-hyperglycemic agent. As it is highly crystalline and has poor compaction properties, it is difficult to form tablets by direct compression. The aim of this study was to develop adequate metformin tablets, pharmaceutically equivalent to the reference product, Glucophage® (marketed as Glifage® in Brazil. Metformin 500mg tablets were produced by wet granulation with various binders (A = starch, B = starch 1500®, C = PVP K30®, D = PVP K90®. The tablets were analyzed for their hardness, friability, disintegration, dissolution, content uniformity and dissolution profile (basket apparatus at 50 rpm, pH 6.8 phosphate buffer. The 4 formulations, F1 (5% A and 5% C, F2 (5% B and 5% C, F3 (10% C and F4 (5% D, demonstrated adequate uniformity of content, hardness, friability, disintegration and total drug dissolution after 30 minutes (F1, F2 and F4, and after 60 minutes (F3. The drug release time profiles fitted a Higuchi model (F1, F2 and F3, similarly to the pharmaceutical reference, or a zero order model (F4. The dissolution efficiency for all the formulations was 75%, except for F3 (45%. F1 and F2 were thus equivalent to Glifage®. Keywords: dissolution; metformin; tablet; binder; pharmaceutical equivalence

  1. Diversity, variation and fairness: Equivalence in national level language assessments

    Directory of Open Access Journals (Sweden)

    Albert Weideman

    2017-01-01

    Full Text Available The post-1994 South African constitution proudly affirms the language diversity of the country, as do subsequent laws, while ministerial policies, both at further and higher education level, similarly promote the use of all 11 official languages in education. However, such recognition of diversity presents several challenges to accommodate potential variation. In language education at secondary school, which is nationally assessed, the variety being promoted immediately raises issues of fairness and equivalence. The final high-stakes examination of learners’ ability in home language at the exit level of their pre-tertiary education is currently contentious in South Africa. It is known, for example, that in certain indigenous languages, the exit level assessments barely discriminate among learners with different abilities, while in other languages they do. For that reason, the Council for Quality Assurance in General and Further Education, Umalusi, has commissioned several reports to attempt to understand the nature of the problem. This article will deal with a discussion of a fourth attempt by Umalusi to solve the problem. That attempt, undertaken by a consortium of four universities, has already delivered six interim reports to this statutory body, and the article will consider some of their content and methodology. In their reconceptualisation of the problem, the applied linguists involved first sought to identify the theoretical roots of the current curriculum in order to articulate more sharply the construct being assessed. That provides the basis for a theoretical justification of the several solutions being proposed, as well as for the preliminary designs of modifications to current, and the introduction of new assessments. The impact of equivalence of measurement as a design requirement will be specifically discussed, with reference to the empirical analyses of results of a number of pilots of equivalent tests in different languages.

  2. A Bioequivalence Approach for Generic Narrow Therapeutic Index Drugs: Evaluation of the Reference-Scaled Approach and Variability Comparison Criterion

    OpenAIRE

    Jiang, Wenlei; Makhlouf, Fairouz; Schuirmann, Donald J.; Zhang, Xinyuan; Zheng, Nan; Conner, Dale; Yu, Lawrence X.; Lionberger, Robert

    2015-01-01

    Various health communities have expressed concerns regarding whether average bioequivalence (BE) limits (80.00–125.00%) for the 90% confidence interval of the test-to-reference geometric mean ratio are sufficient to ensure therapeutic equivalence between a generic narrow therapeutic index (NTI) drug and its reference listed drug (RLD). Simulations were conducted to investigate the impact of different BE approaches for NTI drugs on study power, including (1) direct tightening of average BE lim...

  3. Energy balance analysis in non linear dynamic equivalent systems.

    Directory of Open Access Journals (Sweden)

    Carlos Iturregui Arranz

    2018-01-01

    The powers, energies and works developed are analyzed, creating a precise balance since energy enters selectively. Hence, an equivalent damping containing a viscous and hysteretic part is predictable, accordingly to the variation of the building’s nonlinear properties. Evaluation of the adequateness and safety level are also obtainable. The controlled parameters contrasted with the balance predicts the structure’s MDOF situation, at any moment related with seismic events. This methodology can be used to stablish a systematic control of nonlinearities for other structural schemes.

  4. Mapping wordnets from the perspective of inter-lingual equivalence

    Directory of Open Access Journals (Sweden)

    Ewa Katarzyna Rudnicka

    2017-12-01

    Full Text Available Mapping wordnets from the perspective of inter-lingual equivalence This paper explores inter-lingual equivalence from the perspective of linking two large lexico-semantic databases, namely the Princeton WordNet of English and the plWordnet (pl. Słowosieć of Polish. Wordnets are built as networks of lexico-semantic relations between words and their meanings, and constitute a type of monolingual dictionary cum thesaurus. The development of wordnets for different languages has given rise to many wordnet linking projects (e.g. EuroWordNet, Vossen, 2002. Regardless of a linking method used, these projects require defining rules for establishing equivalence links between wordnet building blocks, known as synsets (sets of synonymous lexical units, i.e., lemma-sense pairs. In this paper an analysis is carried out of a set of inter-wordnet relations used in the mapping of the plWordNet onto the Princeton WordNet, and an attempt is made to relate them to equivalence taxonomies described in specialist literature on bilingual lexicography and translation.   Rzutowanie wordnetów w perspektywie ekwiwalencji międzyjęzykowej Artykuł przedstawia analizę zjawiska ekwiwalencji międzyjęzykowej z perspektywy powiązania dwóch wielkich wordnetów: polskiej Słowosieci i angielskiego WordNetu princetońskiego. Wordnety są relacyjnymi bazami danych leksykalno-semantycznych opisującymi sieć relacji leksykalno-semantycznych pomiędzy słowami i ich znaczeniami. Stanowią zatem rodzaj słownika jednojęzycznego połączonego z tezaurusem. Rozwój wordnetów dla wielu języków świata zaowocował następnie ich wzajemnymi powiązaniami. Wymagało to zdefiniowania metodologii dla ustalenia ekwiwalencji pomiędzy ich podstawowymi elementami tzn. synsetami, które są zbiorami synonimicznych jednostek leksykalnych tzn. par lemat numer znaczenia. W artykule analizujemy zbiór relacji międzywordnetowych używanych w rzutowaniu pomiędzy Słowosiecią a Word

  5. On proving confluence modulo equivalence for Constraint Handling Rules

    DEFF Research Database (Denmark)

    Christiansen, Henning; Kirkeby, Maja Hanne

    2017-01-01

    Previous results on proving confluence for Constraint Handling Rules are extended in two ways in order to allow a larger and more realistic class of CHR programs to be considered confluent. Firstly, we introduce the relaxed notion of confluence modulo equivalence into the context of CHR: while...... with meta-level restrictions that reflect the non-logical and incomplete predicates. This language represents subproofs as diagrams, which facilitates a systematic enumeration of proof cases, pointing forward to a mechanical support for such proofs. The Project is supported by The Danish...

  6. [Contrast vision-definitions, conversions, and equivalence tables].

    Science.gov (United States)

    Bach, M; Hoffmann, M B; Jägle, H; Heinrich, S P; Schiefer, U; Wesemann, W

    2017-04-01

    Human contrast vision and its quantitative assessment are gaining more attention. Publications on this topic can be confusing due to the overabundance of differing definitions and quantification of contrast vision. As a case in point, in Germany, contrast ratios as required for certain driving licenses and the DIN-defined contrast ratio are reciprocal. In this article, the five most important definitions of luminance contrast and contrast vision (Michelson, Weber, contrast ratios, logCS) are presented. We detail the specific domains for them, give formulae to convert between all of them and provide a table with equivalent values. We recommend the unit logCS wherever possible.

  7. Granger Causality and Transfer Entropy Are Equivalent for Gaussian Variables

    Science.gov (United States)

    Barnett, Lionel; Barrett, Adam B.; Seth, Anil K.

    2009-12-01

    Granger causality is a statistical notion of causal influence based on prediction via vector autoregression. Developed originally in the field of econometrics, it has since found application in a broader arena, particularly in neuroscience. More recently transfer entropy, an information-theoretic measure of time-directed information transfer between jointly dependent processes, has gained traction in a similarly wide field. While it has been recognized that the two concepts must be related, the exact relationship has until now not been formally described. Here we show that for Gaussian variables, Granger causality and transfer entropy are entirely equivalent, thus bridging autoregressive and information-theoretic approaches to data-driven causal inference.

  8. Equivalent Theory and Retrieval of Effective Metamaterials Parameters

    CERN Document Server

    Feng, Simin

    2010-01-01

    Currently widely used retrieval method often suffers from unreal resonant-antiresonant coupling in extracted permittivity and permeability of metamaterals; and the retrieved material parameters are length-dependent. Here, we apply equivalent theory to discuss a general unit-cell design criterion for length-independent retrieval of effective metamaterial parameters from a single layer of unit cells. We introduce a graphical method which directly retrieves the effective ordinary and extraordinary permittivities and permeabilities without computing refractive index and impedance as middle steps. Our method resolves the longstanding resonant-antiresonant mystery.

  9. On the Applicability of the Surface Equivalence Theorem Inside Enclosures

    DEFF Research Database (Denmark)

    Franek, Ondrej; Sørensen, Morten; Ebert, Hans

    2012-01-01

    A scenario of a generic printed circuit board (PCB) representing an electronic module inside a metallic enclosure is studied numerically. Following the surface equivalence theorem, the PCB is replaced with surface currents running on a Huygens box (HB) inside the enclosure and near-field errors...... with respect to the full model are observed. In concordance with previous work it is found that leaving the HB empty leads to significant errors. This time, however, countermeasures in the form of including the ground plane or substrate of the PCB inside the HB have the desired effect of reducing the errors...

  10. Polyhedral aspects of score equivalence in Bayesian network structure learning

    Czech Academy of Sciences Publication Activity Database

    Cussens, J.; Haws, D.; Studený, Milan

    2017-01-01

    Roč. 164, 1-2 (2017), s. 285-324 ISSN 0025-5610 R&D Projects: GA ČR GA13-20012S; GA ČR(CZ) GA16-12010S Institutional support: RVO:67985556 Keywords : family-variable polytope * characteristic-imset polytope * score equivalent face/facet * supermodular set function Subject RIV: BA - General Mathematics Impact factor: 2.446, year: 2016 http:// library .utia.cas.cz/separaty/2017/MTR/studeny-0475315.pdf

  11. Weak Equivalence Principle Test on a Sounding Rocket

    CERN Document Server

    Phillips, James D; Popescu, Eugeniu M; Rocco, Emanuele; Thapa, Rajesh; Reasenberg, Robert D; Lorenzini, Enrico C

    2010-01-01

    SR-POEM, our principle of equivalence measurement on a sounding rocket, will compare the free fall rate of two substances yielding an uncertainty of E-16 in the estimate of \\eta. During the past two years, the design concept has matured and we have been working on the required technology, including a laser gauge that is self aligning and able to reach 0.1 pm per root hertz for periods up to 40 s. We describe the status and plans for this project.

  12. Rethinking bioequivalence and equivalence requirements of orally inhaled drug products

    Directory of Open Access Journals (Sweden)

    Dina Al-Numani

    2015-12-01

    Full Text Available Orally inhaled drug products (OIPs, such as corticosteroids and bronchodilators, are at the forefront of asthma and chronic obstructive pulmonary disease treatments, two diseases that afflict worldwide populations. Introducing generics of these products is essential, as the pricing of these medications remain a barrier to adequate patient care. Currently, there is no consensus between regulatory bodies as to the bioequivalence and equivalence requirements of OIPs that are intended for local action in the lungs. This manuscript critically reviews these requirements and presents future directions for clinicians, scientists, and regulators to consider to optimize the development and approval of OIPs.

  13. Formalization, equivalence and generalization of basic resonance electrical circuits

    Science.gov (United States)

    Penev, Dimitar; Arnaudov, Dimitar; Hinov, Nikolay

    2017-12-01

    In the work are presented basic resonance circuits, which are used in resonance energy converters. The following resonant circuits are considered: serial, serial with parallel load parallel capacitor, parallel and parallel with serial loaded inductance. For the circuits under consideration, expressions are generated for the frequencies of own oscillations and for the equivalence of the active power emitted in the load. Mathematical expressions are graphically constructed and verified using computer simulations. The results obtained are used in the model based design of resonant energy converters with DC or AC output. This guaranteed the output indicators of power electronic devices.

  14. Equivalence of ELISpot assays demonstrated between major HIV network laboratories.

    Directory of Open Access Journals (Sweden)

    Dilbinder K Gill

    2010-12-01

    Full Text Available The Comprehensive T Cell Vaccine Immune Monitoring Consortium (CTC-VIMC was created to provide standardized immunogenicity monitoring services for HIV vaccine trials. The ex vivo interferon-gamma (IFN-γ ELISpot is used extensively as a primary immunogenicity assay to assess T cell-based vaccine candidates in trials for infectious diseases and cancer. Two independent, GCLP-accredited central laboratories of CTC-VIMC routinely use their own standard operating procedures (SOPs for ELISpot within two major networks of HIV vaccine trials. Studies are imperatively needed to assess the comparability of ELISpot measurements across laboratories to benefit optimal advancement of vaccine candidates.We describe an equivalence study of the two independently qualified IFN-g ELISpot SOPs. The study design, data collection and subsequent analysis were managed by independent statisticians to avoid subjectivity. The equivalence of both response rates and positivity calls to a given stimulus was assessed based on pre-specified acceptance criteria derived from a separate pilot study.Detection of positive responses was found to be equivalent between both laboratories. The 95% C.I. on the difference in response rates, for CMV (-1.5%, 1.5% and CEF (-0.4%, 7.8% responses, were both contained in the pre-specified equivalence margin of interval [-15%, 15%]. The lower bound of the 95% C.I. on the proportion of concordant positivity calls for CMV (97.2% and CEF (89.5% were both greater than the pre-specified margin of 70%. A third CTC-VIMC central laboratory already using one of the two SOPs also showed comparability when tested in a smaller sub-study.The described study procedure provides a prototypical example for the comparison of bioanalytical methods in HIV vaccine and other disease fields. This study also provides valuable and unprecedented information for future vaccine candidate evaluations on the comparison and pooling of ELISpot results generated by the CTC

  15. Equivalent and Alternative Forms for BF Gravity with Immirzi Parameter

    Directory of Open Access Journals (Sweden)

    Merced Montesinos

    2011-11-01

    Full Text Available A detailed analysis of the BF formulation for general relativity given by Capovilla, Montesinos, Prieto, and Rojas is performed. The action principle of this formulation is written in an equivalent form by doing a transformation of the fields of which the action depends functionally on. The transformed action principle involves two BF terms and the two Lorentz invariants that appear in the original action principle generically. As an application of this formalism, the action principle used by Engle, Pereira, and Rovelli in their spin foam model for gravity is recovered and the coupling of the cosmological constant in such a formulation is obtained.

  16. Tomographic quantum cryptography: equivalence of quantum and classical key distillation.

    Science.gov (United States)

    Bruss, Dagmar; Christandl, Matthias; Ekert, Artur; Englert, Berthold-Georg; Kaszlikowski, Dagomir; Macchiavello, Chiara

    2003-08-29

    The security of a cryptographic key that is generated by communication through a noisy quantum channel relies on the ability to distill a shorter secure key sequence from a longer insecure one. For an important class of protocols, which exploit tomographically complete measurements on entangled pairs of any dimension, we show that the noise threshold for classical advantage distillation is identical with the threshold for quantum entanglement distillation. As a consequence, the two distillation procedures are equivalent: neither offers a security advantage over the other.

  17. Dynamic determination of equivalent CT source models for personalized dosimetry

    Directory of Open Access Journals (Sweden)

    Rosendahl Stephan

    2017-09-01

    Full Text Available With improvements in CT technology, the need for reliable patient-specific dosimetry increased in the recent years. The accuracy of Monte-Carlo simulations for absolute dose estimation is related to scanner specific information on the X-ray spectra of the scanner as well as the form filter geometries and compositions. In this work a mobile measurement setup is developed, which allows both to determine the X-ray spectra and equivalent form filter of a specific scanner from just one helical scan in less than 2 minutes.

  18. Automatically extracting functionally equivalent proteins from SwissProt

    Directory of Open Access Journals (Sweden)

    Martin Andrew CR

    2008-10-01

    Full Text Available Abstract Background There is a frequent need to obtain sets of functionally equivalent homologous proteins (FEPs from different species. While it is usually the case that orthology implies functional equivalence, this is not always true; therefore datasets of orthologous proteins are not appropriate. The information relevant to extracting FEPs is contained in databanks such as UniProtKB/Swiss-Prot and a manual analysis of these data allow FEPs to be extracted on a one-off basis. However there has been no resource allowing the easy, automatic extraction of groups of FEPs – for example, all instances of protein C. We have developed FOSTA, an automatically generated database of FEPs annotated as having the same function in UniProtKB/Swiss-Prot which can be used for large-scale analysis. The method builds a candidate list of homologues and filters out functionally diverged proteins on the basis of functional annotations using a simple text mining approach. Results Large scale evaluation of our FEP extraction method is difficult as there is no gold-standard dataset against which the method can be benchmarked. However, a manual analysis of five protein families confirmed a high level of performance. A more extensive comparison with two manually verified functional equivalence datasets also demonstrated very good performance. Conclusion In summary, FOSTA provides an automated analysis of annotations in UniProtKB/Swiss-Prot to enable groups of proteins already annotated as functionally equivalent, to be extracted. Our results demonstrate that the vast majority of UniProtKB/Swiss-Prot functional annotations are of high quality, and that FOSTA can interpret annotations successfully. Where FOSTA is not successful, we are able to highlight inconsistencies in UniProtKB/Swiss-Prot annotation. Most of these would have presented equal difficulties for manual interpretation of annotations. We discuss limitations and possible future extensions to FOSTA, and

  19. Quartz red TL SAR equivalent dose overestimation for Chinese loess

    DEFF Research Database (Denmark)

    Lai, Z.P.; Murray, A.S.; Bailey, R.M.

    2006-01-01

    For the red TL of quartz extracted from Chinese loess, the single-aliquot regenerative-dose (SAR) procedure overestimates the known laboratory doses in dose recovery test. The overestimation is the result of the first heating during the measurement of natural TL signal causing a sensitivity...... reduction, which is not corrected for using a SAR protocol. The SARA procedure was used to measure the sensitivity change. Using this as a correction factor is tested by comparison with the quartz optically stimulated luminiscence (OSL) equivalent dose. SARA is also employed to determine the residual level...

  20. Equivalence Problem Solvability in Biparametric Gateway Program Models

    Directory of Open Access Journals (Sweden)

    A. E. Molchanov

    2014-01-01

    Full Text Available Algebraic program models with procedures are designed to analyze program semantic properties on their models called program schemes. Procedural liberisation problem and equivalence problem are stated for program models with procedures in which both defining parameters are chosen independently. Program models with procedures built over a given program model without procedures are investigated. Algorithms for both stated tasks are proposed for models where an additional restriction is applied: the intersection emptiness problem is solvable in the program model without procedures. Polynomial estimates for the complexity of the algorithms are shown. Some topics for further investigation are proposed.

  1. Equivalence Checking of Combinational Circuits using Boolean Expression Diagrams

    DEFF Research Database (Denmark)

    Hulgaard, Henrik; Williams, Poul Frederick; Andersen, Henrik Reif

    1999-01-01

    The combinational logic-level equivalence problem is to determine whether two given combinational circuits implement the same Boolean function. This problem arises in a number of CAD applications, for example when checking the correctness of incremental design changes (performed either manually...... or by a design automation tool).This paper introduces a data structure called Boolean Expression Diagrams (BEDs) and two algorithms for transforming a BED into a Reduced Ordered Binary Decision Diagram (OBDD). BEDs are capable of representing any Boolean circuit in linear space and can exploit structural...

  2. Global education implications of the foreign pharmacy graduate equivalency examination.

    Science.gov (United States)

    Alkhateeb, Fadi M; Clauson, Kevin A; Latif, David A; Al-Rousan, Rabaa M

    2010-06-15

    Although the Foreign Pharmacy Graduate Equivalency Examination (FPGEE) is not intended to measure educational outcomes or institutional effectiveness, it may be a reliable and valid criterion to assess the quality or success of international pharmacy programs. This comprehensive review describes the evolution and historical milestones of the FPGEE, along with trends in structure, administration, and passing rates, and the impact of country of origin on participant performance. Similarities between the FPGEE and the Pharmacy Curriculum Outcomes Assessment (PCOA) are also explored. This paper aims to provide a global prospective and insight for foreign academic institutions into parameters for evaluating their students' educational capabilities.

  3. Bone-seeking therapeutic radiopharmaceuticals

    Directory of Open Access Journals (Sweden)

    Srivastava Suresh C.

    2002-01-01

    Full Text Available Bone-seeking therapeutic radiopharmaceuticals are utilized on the basis of the radionuclide?s particulate emissions (primarily low to intermediate beta emission. The requirements therefore are different from those of bone imaging agents that consist mainly of short-lived single photon emitters. Lately, the therapeutic bone seeking radiopharmaceuticals have attained increasing importance due to their potential role in alleviating pain from osseous metastases in cancer patients, for the treatment of joint pain resulting from inflamed synovium (radiosynoviorthesis, or radiosynovectomy, or from various other forms of arthritic disease. There is, however, a paucity of published data on the bio-pharmacokinetics of these agents when used following intravenous administration for bone pain palliation. This paper will briefly review and summarize the presently available chemical and biopharmacokinetic information on the various clinically approved as well as experimental bone-localizing therapeutic radiopharmaceuticals, and make projections on their clinical application for the treatment of primary/metastatic cancer in bone.

  4. Therapeutic hypothermia for acute stroke

    DEFF Research Database (Denmark)

    Olsen, Tom Skyhøj; Weber, Uno Jakob; Kammersgaard, Lars Peter

    2003-01-01

    Experimental evidence and clinical experience show that hypothermia protects the brain from damage during ischaemia. There is a growing hope that the prevention of fever in stroke will improve outcome and that hypothermia may be a therapeutic option for the treatment of stroke. Body temperature...... is directly related to stroke severity and outcome, and fever after stroke is associated with substantial increases in morbidity and mortality. Normalisation of temperature in acute stroke by antipyretics is generally recommended, although there is no direct evidence to support this treatment. Despite its...... obvious therapeutic potential, hypothermia as a form of neuroprotection for stroke has been investigated in only a few very small studies. Therapeutic hypothermia is feasible in acute stroke but owing to serious side-effects--such as hypotension, cardiac arrhythmia, and pneumonia--it is still thought...

  5. Conflicts in the therapeutic field

    Directory of Open Access Journals (Sweden)

    Antonino Aprea

    2012-06-01

    Full Text Available How the analytical knowledge that compare human consciousness with that, even more disturbing, moving behind his fifth can be said to be “for peace”? It can be - and this will be the contribution of the proposal - the same tortuous and enigmatic of therapeutic practice, with its hesitations and his impulses, to outline a path crossing and overcoming the conflict? May, finally, peace, in the sense of feasibility of intra-and interpersonal dialectic instead of tearing and hostileconfrontation with oneself and with the other, to be a reference in some crucial pivot of ethical therapeutic work? To these questions the intervention seeks to answer retracing some of the highlights of almost three years of therapeutic work with a young woman and her family.

  6. Oligonucleotide conjugates for therapeutic applications.

    Science.gov (United States)

    Winkler, Johannes

    2013-07-01

    Insufficient pharmacokinetic properties and poor cellular uptake are the main hurdles for successful therapeutic development of oligonucleotide agents. The covalent attachment of various ligands designed to influence the biodistribution and cellular uptake or for targeting specific tissues is an attractive possibility to advance therapeutic applications and to expand development options. In contrast to advanced formulations, which often consist of multiple reagents and are sensitive to a variety of preparation conditions, oligonucleotide conjugates are defined molecules, enabling structure-based analytics and quality control techniques. This review gives an overview of current developments of oligonucleotide conjugates for therapeutic applications. Attached ligands comprise peptides, proteins, carbohydrates, aptamers and small molecules, including cholesterol, tocopherol and folic acid. Important linkage types and conjugation methods are summarized. The distinct ligands directly influence biochemical parameters, uptake mechanisms and pharmacokinetic properties.

  7. [Therapeutic touch and anorexia nervosa].

    Science.gov (United States)

    Satori, Nadine

    2016-01-01

    An innovative practice, therapeutic touch has been used for around ten years in the treatment of eating disorders. Delivered by nurse clinicians having received specific training, this approach is based on nursing diagnoses which identify the major symptoms of this pathology. The support is built around the body and its perceptions. Through the helping relationship, it mobilises the patient's resources to favour a relationship of trust, a letting-go, physical, psychological and emotional relaxation, and improves the therapeutic alliance. Copyright © 2016. Published by Elsevier Masson SAS.

  8. Therapeutic options for visceral leishmaniasis.

    Science.gov (United States)

    Monge-Maillo, Begoña; López-Vélez, Rogelio

    2013-11-01

    Visceral leishmaniasis (VL), also known as Kala-Azar, is a disseminated protozoal infection caused principally by Leishmania donovani and Leishmania infantum (known as Leishmania chagasi in South America). The therapeutic options for VL are diverse and depend on different factors, such as the geographical area of the infection, development of resistance to habitual treatments, HIV co-infection, malnourishment and other concomitant infections. This article provides an exhaustive review of the literature regarding studies published on the treatment of VL, and gives therapeutic recommendations stratified according to their level of evidence, the species of Leishmania implicated and the geographical location of the infection.

  9. Therapeutic Adherence in Smoking Therapy

    Directory of Open Access Journals (Sweden)

    María Salvador Manzano

    2010-02-01

    Full Text Available Therapeutic adherence is a complex and multidimensional concept. The percentage of adherence to treatments involving a change in lifestyle, such as quitting smoking, is lower than in other disorders, a fact which has relevant clinical, psychological and economic consequences. This paper aims to review the associated factors with adherence to therapy in smoking treatment. Strategies to enhance therapeutic adherence involve the adequate choice of treatment, to know the smoker´s characteristics, breaking down organizational barriers in health system and the training of health professionals in communication skills with patients.

  10. Therapeutics for Equine Endocrine Disorders.

    Science.gov (United States)

    Durham, Andy E

    2017-04-01

    Equine endocrine disease is commonly encountered by equine practitioners. Pituitary pars intermedia dysfunction (PPID) and equine metabolic syndrome (EMS) predominate. The most logical therapeutic approach in PPID uses dopamine agonists; pergolide mesylate is the most common. Bromocryptine and cabergoline are alternative drugs with similar actions. Drugs from other classes have a poor evidence basis, although cyproheptadine and trilostane might be considered. EMS requires management changes as the primary approach; reasonable justification for use of drugs such as levothyroxine and metformin may apply. Therapeutic options exist in rare cases of diabetes mellitus, diabetes insipidus, hyperthyroidism, and critical illness-related corticosteroid insufficiency. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Neural Net Gains Estimation Based on an Equivalent Model

    Directory of Open Access Journals (Sweden)

    Karen Alicia Aguilar Cruz

    2016-01-01

    Full Text Available A model of an Equivalent Artificial Neural Net (EANN describes the gains set, viewed as parameters in a layer, and this consideration is a reproducible process, applicable to a neuron in a neural net (NN. The EANN helps to estimate the NN gains or parameters, so we propose two methods to determine them. The first considers a fuzzy inference combined with the traditional Kalman filter, obtaining the equivalent model and estimating in a fuzzy sense the gains matrix A and the proper gain K into the traditional filter identification. The second develops a direct estimation in state space, describing an EANN using the expected value and the recursive description of the gains estimation. Finally, a comparison of both descriptions is performed; highlighting the analytical method describes the neural net coefficients in a direct form, whereas the other technique requires selecting into the Knowledge Base (KB the factors based on the functional error and the reference signal built with the past information of the system.

  12. Experimental Search for a Violation of Einstein's Equivalence Principle

    Science.gov (United States)

    Abercrombie, Michael; Archibald, Adam; Madziwa-Nussinov, Tsitsi; Wagoner, Kasey; Cowsik, Ramanath

    2015-04-01

    The Equivalence Principle (EP) states that a gravitational field is locally equivalent to a uniformly accelerated reference frame, and it is this idea that Einstein's Theory of General Relativity (GR) is largely based upon. A direct consequence of the EP is the universality of free fall; that is, all objects, regardless of their composition, fall at the same rate in a given gravitational field. Motivated by theoretical attempts to unify GR with the Standard Model that predict possible violations of the universality of free fall, we have developed an Eötvös-type torsion balance experiment capable of testing the EP at unprecedented sensitivities. Using a balance configured as a composition dipole with an azimuthally symmetric mass distribution, a violation of the EP would cause a diurnal modulation of the balance orientation in response to the gravitational field produced by the Sun. To monitor the torsion balance we use a multi-slit auto-collimating optical level capable of measuring angular displacements on the scale of nanoradians. The recent relocation of our experiment to an isolated bunker built into a hillside at the Tyson Research Facility reduces the seismic and thermal noise in our measurements.

  13. Is albuminuria a myocardial infarction risk equivalent for atherothrombotic events?

    Science.gov (United States)

    Rein, Philipp; Saely, Christoph H; Vonbank, Alexander; Fraunberger, Peter; Drexel, Heinz

    2015-05-01

    People with chronic kidney disease frequently experience cardiovascular events. This study sought to investigate whether the presence of albuminuria displays a vascular risk equivalent to that in patients with prior myocardial infarction. Albuminuria was defined as a urinary albumin to creatinine ratio of 30 μg/mg or greater in 852 consecutive patients undergoing coronary angiography. Prospectively, we recorded vascular events over 3.2±1.2 years. From our patients, 513 (60.2%) had neither albuminuria nor a history of MI, 126 (14.8%) had albuminuria without prior MI, 137 (16.1%) did not have albuminuria but had a history of MI, and 76 (8.9%) had both, albuminuria and prior MI. Compared with the incidence of the composite endpoint among normoalbuminuric patients with no prior MI (11.9%), event rates nearly doubled both in patients with albuminuria without prior MI (24.6%; p=0.003) and in normoalbuminuric patients with a history of prior MI (21.2%; p=0.004) and were highest in patients with both, albuminuria and prior MI (36.8%; palbuminuria and no prior history of MI and those with normoalbuminuria but prior MI (p=0.972). Moreover, the event rate in patients with both, albuminuria and history of MI, was significantly higher (palbuminuria is a CAD risk equivalent. Thus, cardiovascular risk factors in albuminuric patients should be treated as aggressively as in patients with prior MI. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. Equivalent Continuum Modeling for Shock Wave Propagation in Jointed Media

    Energy Technology Data Exchange (ETDEWEB)

    Vorobiev, O; Antoun, T

    2009-12-11

    This study presents discrete and continuum simulations of shock wave propagating through jointed media. The simulations were performed using the Lagrangian hydrocode GEODYN-L with joints treated explicitly using an advanced contact algorithm. They studied both isotropic and anisotropic joint representations. For an isotropically jointed geologic medium, the results show that the properties of the joints can be combined with the properties of the intact rock to develop an equivalent continuum model suitable for analyzing wave propagation through the jointed medium. For an anisotropically jointed geologic medium, they found it difficult to develop an equivalent continuum (EC) model that matches the response derived from mesoscopic simulation. They also performed simulations of wave propagation through jointed media. Two appraoches are suggested for modeling the rock mass. In one approach, jointed are modeled explicitly in a Lagrangian framework with appropriate contact algorithms used to track motion along the interfaces. In the other approach, the effect of joints is taken into account using a constitutive model derived from mesoscopic simulations.

  15. Data-Driven Method to Estimate Nonlinear Chemical Equivalence.

    Directory of Open Access Journals (Sweden)

    Michael Mayo

    Full Text Available There is great need to express the impacts of chemicals found in the environment in terms of effects from alternative chemicals of interest. Methods currently employed in fields such as life-cycle assessment, risk assessment, mixtures toxicology, and pharmacology rely mostly on heuristic arguments to justify the use of linear relationships in the construction of "equivalency factors," which aim to model these concentration-concentration correlations. However, the use of linear models, even at low concentrations, oversimplifies the nonlinear nature of the concentration-response curve, therefore introducing error into calculations involving these factors. We address this problem by reporting a method to determine a concentration-concentration relationship between two chemicals based on the full extent of experimentally derived concentration-response curves. Although this method can be easily generalized, we develop and illustrate it from the perspective of toxicology, in which we provide equations relating the sigmoid and non-monotone, or "biphasic," responses typical of the field. The resulting concentration-concentration relationships are manifestly nonlinear for nearly any chemical level, even at the very low concentrations common to environmental measurements. We demonstrate the method using real-world examples of toxicological data which may exhibit sigmoid and biphasic mortality curves. Finally, we use our models to calculate equivalency factors, and show that traditional results are recovered only when the concentration-response curves are "parallel," which has been noted before, but we make formal here by providing mathematical conditions on the validity of this approach.

  16. Data-Driven Method to Estimate Nonlinear Chemical Equivalence.

    Science.gov (United States)

    Mayo, Michael; Collier, Zachary A; Winton, Corey; Chappell, Mark A

    2015-01-01

    There is great need to express the impacts of chemicals found in the environment in terms of effects from alternative chemicals of interest. Methods currently employed in fields such as life-cycle assessment, risk assessment, mixtures toxicology, and pharmacology rely mostly on heuristic arguments to justify the use of linear relationships in the construction of "equivalency factors," which aim to model these concentration-concentration correlations. However, the use of linear models, even at low concentrations, oversimplifies the nonlinear nature of the concentration-response curve, therefore introducing error into calculations involving these factors. We address this problem by reporting a method to determine a concentration-concentration relationship between two chemicals based on the full extent of experimentally derived concentration-response curves. Although this method can be easily generalized, we develop and illustrate it from the perspective of toxicology, in which we provide equations relating the sigmoid and non-monotone, or "biphasic," responses typical of the field. The resulting concentration-concentration relationships are manifestly nonlinear for nearly any chemical level, even at the very low concentrations common to environmental measurements. We demonstrate the method using real-world examples of toxicological data which may exhibit sigmoid and biphasic mortality curves. Finally, we use our models to calculate equivalency factors, and show that traditional results are recovered only when the concentration-response curves are "parallel," which has been noted before, but we make formal here by providing mathematical conditions on the validity of this approach.

  17. Small vacuum energy from small equivalence violation in scalar gravity

    Science.gov (United States)

    Agrawal, Prateek; Sundrum, Raman

    2017-05-01

    The theory of scalar gravity proposed by Nordström, and refined by Einstein and Fokker, provides a striking analogy to general relativity. In its modern form, scalar gravity appears as the low-energy effective field theory of the spontaneous breaking of conformal symmetry within a CFT, and is AdS/CFT dual to the original Randall-Sundrum I model, but without a UV brane. Scalar gravity faithfully exhibits several qualitative features of the cosmological constant problem of standard gravity coupled to quantum matter, and the Weinberg no-go theorem can be extended to this case as well. Remarkably, a solution to the scalar gravity cosmological constant problem has been proposed, where the key is a very small violation of the scalar equivalence principle, which can be elegantly formulated as a particular type of deformation of the CFT. In the dual AdS picture this involves implementing Goldberger-Wise radion stabilization where the Goldberger-Wise field is a pseudo-Nambu Goldstone boson. In quantum gravity however, global symmetries protecting pNGBs are not expected to be fundamental. We provide a natural six-dimensional gauge theory origin for this global symmetry and show that the violation of the equivalence principle and the size of the vacuum energy seen by scalar gravity can naturally be exponentially small. Our solution may be of interest for study of non-supersymmetric CFTs in the spontaneously broken phase.

  18. Validation of artificial skin equivalents as in vitro testing systems

    Science.gov (United States)

    Schmitt, Robert; Marx, Ulrich; Walles, Heike; Schober, Lena

    2011-03-01

    With the increasing complexity of the chemical composition of pharmaceuticals, cosmetics and everyday substances, the awareness of potential health issues and long term damages for humanoid organs is shifting into focus. Artificial in vitro testing systems play an important role in providing reliable test conditions and replacing precarious animal testing. Especially artificial skin equivalents ASEs are used for a broad spectrum of studies like penetration, irritation and corrosion of substances. One major challenge in tissue engineering is the qualification of each individual ASE as in vitro testing system. Due to biological fluctuations, the stratum corneum hornified layer of some ASEs may not fully develop or other defects might occur. For monitoring these effects we developed an fully automated Optical Coherence Tomography device. Here, we present different methods to characterize and evaluate the quality of the ASEs based on image and data processing of OCT B-scans. By analysing the surface structure, defects, like cuts or tears, are detectable. A further indicator for the quality of the ASE is the morphology of the tissue. This allows to determine if the skin model has reached the final growth state. We found, that OCT is a well suited technology for automatically characterizing artificial skin equivalents and validating the application as testing system.

  19. Infrared lens thermal effect: equivalent focal shift and calculating model

    Science.gov (United States)

    Zhang, Cheng-shuo; Shi, Zelin; Feng, Bin; Xu, Bao-shu

    2014-11-01

    It's well-know that the focal shift of infrared lens is the major factor in degeneration of imaging quality when temperature change. In order to figure out the connection between temperature change and focal shift, partial differential equations of thermal effect on light path are obtained by raytrace method, to begin with. The approximately solution of the PDEs show that focal shift is proportional to temperature change. And a formula to compute the proportional factor is given. In order to understand infrared lens thermal effect deeply, we use defocus by image plane shift at constant temperature to equivalently represent thermal effect on infrared lens. So equivalent focal shift (EFS) is defined and its calculating model is proposed at last. In order to verify EFS and its calculating model, Physical experimental platform including a motorized linear stage with built-in controller, blackbody, target, collimator, IR detector, computer and other devices is developed. The experimental results indicate that EFS make the image plane shift at constant temperature have the same influence on infrared lens as thermal effect and its calculating model is correct.

  20. Learning unions of boxes with membership and equivalence queries

    Energy Technology Data Exchange (ETDEWEB)

    Goldberg, P.W. [Sandia National Laboratories, Albuquerque, NM (United States); Goldman, S.A.; Mathias, H.D. [Washington Univ., St. Louis, MO (United States)

    1994-07-01

    The authors present two algorithms that use membership and equivalence queries to exactly identify the concepts given by the union of s discretized axis-parallel boxes in d-dimensional discretized Euclidean space where there are n discrete values that each coordinate can have. The first algorithm receives at most sd counterexamples and uses time and membership queries polynomial in s and log n for d any constant. Further, all equivalence queries made can be formulated as the union of O(sd log(s)) axis-parallel boxes. Next, they introduce a new complexity measure that better captures the complexity of a union of boxes than simply the number of boxes and dimensions. Their new measure, {sigma}, is the number of segments in the target polyhedron where a segment is a maximum portion of one of the sides of the polyhedron that lies entirely inside or entirely outside each of the other halfspaces defining the polyhedron. They then present an improvement of their first algorithm that uses time and queries polynomial in {sigma} and log n. The hypothesis class used here is decision trees of height at most 2sd. Further they can show that the time and queries used by this algorithm are polynomial in d and log n for s any constant thus generalizing the exact learnability of DNF formulas with a constant number of terms. In fact, this single algorithm is efficient for either s or d constant.

  1. Neutron kerma factors, and water equivalence of some tissue substitutes

    Energy Technology Data Exchange (ETDEWEB)

    Singh, V. P.; Badiger, N. M. [Karnatak University, Department of Physics, Dharwad, 580003 (India); Vega C, H. R., E-mail: kudphyvps@rediffmail.com [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2014-08-15

    The kerma factors and kerma relative to air and water of 24 compounds used as tissue substitutes were calculated for neutron energy from 2.53 x 10{sup -8} up to 29 MeV. The kerma ratio of the tissue substitutes relative to air and water were calculated by the ratio of kerma factors of the tissue substitute to air and water respectively. The water equivalence of the selected tissue substitutes was observed above neutron energies 100 eV. Kerma ratio relative to the air for Poly-vinylidene fluoride and Teflon are found to be nearest to unity in very low energy (up to 1 eV) and above 63 eV respectively. It was found that the natural rubber as a water equivalent tissue substitute compound. The results of the kerma factors in our investigation shows a very good agreement with those published in ICRU-44. We found that at higher neutron energies, the kerma factors and kerma ratios of the selected tissue substitute compounds are approximately same, but differences are large for energies below 100 eV. (Author)

  2. Satellite Test of the Equivalence Principle Uncertainty Analysis

    Science.gov (United States)

    Worden, Paul; Mester, John

    2009-12-01

    STEP, the Satellite Test of the Equivalence Principle, is intended to test the apparent equivalence of gravitational and inertial mass to 1 part in 1018 (Worden et al. in Adv. Space Res. 25(6):1205-1208, 2000). This will be an increase of more than five orders of magnitude over ground-based experiments and lunar laser ranging observations (Su et al. in Phys. Rev. D 50:3614-3636, 1994; Williams et al. in Phys. Rev. D 53:6730-6739, 1996; Schlamminger et al. in Phys. Rev. Lett. 100:041101, 2008). It is essential to have a comprehensive and consistent model of the possible error sources in an experiment of this nature to be able to understand and set requirements, and to evaluate design trade-offs. In the following pages we describe existing software for such an error model and the application of this software to the STEP experiment. In particular we address several issues, including charge and patch effect forces, where our understanding has improved since the launch of GP-B owing to the availability of GP-B data and preliminary analysis results (Everitt et al. in Space Sci. Rev., 2009, this issue; Silbergleit et al. in Space Sci. Rev., 2009, this issue; Keiser et al. in Space Sci. Rev., 2009, this issue; Heifetz et al. in Space Sci. Rev., 2009, this issue; Muhlfelder et al. in Space Sci. Rev., 2009, this issue).

  3. RTL2RTL Formal Equivalence: Boosting the Design Confidence

    Directory of Open Access Journals (Sweden)

    M V Achutha Kiran Kumar

    2014-07-01

    Full Text Available Increasing design complexity driven by feature and performance requirements and the Time to Market (TTM constraints force a faster design and validation closure. This in turn enforces novel ways of identifying and debugging behavioral inconsistencies early in the design cycle. Addition of incremental features and timing fixes may alter the legacy design behavior and would inadvertently result in undesirable bugs. The most common method of verifying the correctness of the changed design is to run a dynamic regression test suite before and after the intended changes and compare the results, a method which is not exhaustive. Modern Formal Verification (FV techniques involving new methods of proving Sequential Hardware Equivalence enabled a new set of solutions for the given problem, with complete coverage guarantee. Formal Equivalence can be applied for proving functional integrity after design changes resulting from a wide variety of reasons, ranging from simple pipeline optimizations to complex logic redistributions. We present here our experience of successfully applying the RTL to RTL (RTL2RTL Formal Verification across a wide spectrum of problems on a Graphics design. The RTL2RTL FV enabled checking the design sanity in a very short time, thus enabling faster and safer design churn. The techniques presented in this paper are applicable to any complex hardware design.

  4. Crosscultural measurement equivalence of the Health Assessment Questionnaire II.

    Science.gov (United States)

    Oude Voshaar, Martijn A H; Glas, Cees A W; ten Klooster, Peter M; Taal, Erik; Wolfe, Frederick; van de Laar, Mart A F J

    2013-06-01

    To evaluate the crosscultural measurement equivalence of the US and Dutch Health Assessment Questionnaire II (HAQ-II) in rheumatoid arthritis (RA). Item response theory (IRT) analyses were performed on US (n = 18,747) and Dutch (n = 1,022) HAQ-II data to evaluate the equivalence of crosscultural item performance. The observed inconsistencies were modeled by assigning country-specific item parameters to biased items. The impact of crosscultural item bias on the comparability of the Dutch and US total scores was analyzed by evaluating the agreement between physical function levels estimated from an IRT model with country-specific item parameters for biased items and physical function levels estimated from the original model that did not account for cultural bias. Two items showed significant crosscultural bias. However, the agreement in physical function estimates between the respecified and original models was very high, with an intraclass correlation coefficient >0.99 and Bland-Altman limits of agreement ranging from -0.08 to -0.01 on a latent scale with a mean of 0 and an SD of 1. This study suggests that the Dutch and US HAQ-II produce total scores that can be interpreted interchangeably across countries in RA studies, despite some minor bias at the item level. Copyright © 2013 by the American College of Rheumatology.

  5. Competitive equivalence maintains persistent inter-clonal boundaries.

    Science.gov (United States)

    Ferrell, David L

    2005-01-01

    Clear boundaries often separate adjacent conspecific competitors. These boundaries may reflect bordering animal territories or regions of inter-organism contact in mobile and non-mobile organisms, respectively. Sessile, clonal organisms often form persistent inter-clonal boundaries despite great variation in competitive ability among genotypes within a population. I show that neighboring clones in the sea anemone Anthopleura elegantissima and three species of the marine hydroid genus Hydractinia are more evenly matched in terms of competitive ability than expected by chance. Hypotheses of genetic relatedness or similar environmental regime shared by neighboring clones are inconsistent with the observed similarities between adjacent competitors in one or both taxa. Instead, inter-clonal borders evidently persist as standoffs between evenly matched competitors. Large differences in competitive ability between bordering clones were rarely observed, suggesting that dominant clones quickly displace or eliminate others in competitive mismatches. This ecological parallel between taxa (i.e., competitive equivalence) exists despite several fundamental differences (e.g., geographical distribution, habitat, body size, longevity), suggesting that competitive equivalence may be a widespread determinant of boundary persistence between adjacent competitors.

  6. Temporal patterns of energy equivalence in temperate soil invertebrates.

    Science.gov (United States)

    Ulrich, Werner; Hoste-Danyłow, Alexia; Faleńczyk-Koziróg, Katarzyna; Hajdamowicz, Izabela; Ilieva-Makulec, Krassimira; Olejniczak, Izabella; Stańska, Marzena; Wytwer, Jolanta

    2015-09-01

    The question whether total population energy use is invariant to species body size (the energy equivalence hypothesis) is central to metabolic ecology and continues to be controversial. While recent comparative field work and meta-analyses pointed to systematic deviations of the underlying allometric scaling laws from predictions of metabolic theory none of these studies included the variability of metabolic scaling in ecological time. Here we used extensive data on the invertebrate soil fauna of Kampinos National Park (Poland) obtained from six consecutive quantitative sampling seasons to show that phylogenetically corrected species density-body weight and population energy use-body weight relationships across all soil fauna species and within trophic groups and body weight classes were highly variable in time. On average, population energy use tended to increase with species body weight in decomposers and phytophages, but not in predators. Despite these trends, our data do not exclude the possibility that energy equivalence marks the central tendency of energy use in the edaphon. Our results highlight the need for long-term studies on energy use to unequivocally assess predictions of metabolic theory.

  7. GAPDH Pseudogenes and the Quantification of Feline Genomic DNA Equivalents

    Directory of Open Access Journals (Sweden)

    A. Katrin Helfer-Hungerbuehler

    2013-01-01

    Full Text Available Quantitative real-time PCR (qPCR is broadly used to detect and quantify nucleic acid targets. In order to determine cell copy number and genome equivalents, a suitable reference gene that is present in a defined number in the genome is needed, preferably as a single copy gene. For most organisms, a variable number of glyceraldehyde-3-phosphate dehydrogenase (GAPDH pseudogenes have been reported. However, it has been suggested that a single-copy of the GAPDH pseudogene is present in the feline genome and that a GAPDH assay can therefore be used to quantify feline genomic DNA (gDNA. The aim of this study was to determine whether one or more GAPDH pseudogenes are present in the feline genome and to provide a suitable alternative qPCR system for the quantification of feline cell copy number and genome equivalents. Bioinformatics and sequencing results revealed that not just one but several closely related GAPDH-like sequences were present in the cat genome. We thus identified, developed, optimized, and validated an alternative reference gene assay using feline albumin (fALB. Our data emphasize the need for an alternative reference gene, apart from the GAPDH pseudogene, for the normalization of gDNA levels. We recommend using the fALB qPCR assay for future studies.

  8. Generic - equivalent drugs use in internal and general medicine patients: distrust, confusion, lack of certainties or of knowledge? Part 3. Clinical issues

    Directory of Open Access Journals (Sweden)

    Roberto Nardi

    2014-05-01

    Full Text Available There are several clinical areas or types of drugs that make prescribing branded drugs preferable, because of potential therapeutic inequivalence or confusion. Bioequivalence criteria may be fine for most drugs, but some conditions may require drug levels with modified variations, like in the case of narrow therapeutic index and critical dose drugs, highly variable drugs and modified-release formulations. Moreover, substitution with generics can be problematic in some patient subpopulations, such as elderly frail people, immunocompromised and transplant patients and patients with epilepsy. We include a list of branded drugs that are considered safer, more effective or with a lower risk of error. The therapeutic substitution is markedly different from therapeutic interchange. The replacement of a brand product with an equivalent has to occur under the control of the physician. At some point in their interaction with individual patients, physicians should let them know that generics are available as substitutes for the more expensive brand-name medications and are equivalent in terms of efficacy and safety. Finally, we hope that a tool like the American Orange book will be also implemented in Italy: it would serve as an accurate reference, that can be useful both to physicians for prescription appropriateness and to patients for their own informed consent.

  9. The renaissance of complement therapeutics.

    Science.gov (United States)

    Ricklin, Daniel; Mastellos, Dimitrios C; Reis, Edimara S; Lambris, John D

    2018-01-01

    The increasing number of clinical conditions that involve a pathological contribution from the complement system - many of which affect the kidneys - has spurred a regained interest in therapeutic options to modulate this host defence pathway. Molecular insight, technological advances, and the first decade of clinical experience with the complement-specific drug eculizumab, have contributed to a growing confidence in therapeutic complement inhibition. More than 20 candidate drugs that target various stages of the complement cascade are currently being evaluated in clinical trials, and additional agents are in preclinical development. Such diversity is clearly needed in view of the complex and distinct involvement of complement in a wide range of clinical conditions, including rare kidney disorders, transplant rejection and haemodialysis-induced inflammation. The existing drugs cannot be applied to all complement-driven diseases, and each indication has to be assessed individually. Alongside considerations concerning optimal points of intervention and economic factors, patient stratification will become essential to identify the best complement-specific therapy for each individual patient. This Review provides an overview of the therapeutic concepts, targets and candidate drugs, summarizes insights from clinical trials, and reflects on existing challenges for the development of complement therapeutics for kidney diseases and beyond.

  10. READING PHILEMON AS THERAPEUTIC NARRATIVE

    African Journals Online (AJOL)

    2010-03-29

    Mar 29, 2010 ... harsh treatment of slaves in the early Christian environment) and a challenging narrative (a more humane conduct of ... therapeutic, it has also proved to be a useful perspective from which to conduct a literary analysis, because it can ...... The Cambridge companion to postmodern theology, pp. 186−202,.

  11. Therapeutic approaches to genetic disorders

    African Journals Online (AJOL)

    salah

    Although prevention is the ideal goal for genetic disorders, various types of therapeutic management are available. Such management approaches depend on the nature of the defect, how well it is understood at the genetic and bio- chemical levels and the practical feasibility of correction. In some conditions.

  12. Therapeutic balloon-assisted enteroscopy

    NARCIS (Netherlands)

    H. Aktas (Huseyin); P.B.F. Mensink (Peter)

    2009-01-01

    textabstractSince the introduction of the first balloon-based enteroscopic technique in 2001, therapeutic balloon-assisted enteroscopy (BAE) using either the single or double balloon enteroscopy technique (respectively SBE and DBE) has evolved rapidly. Argon plasma coagulation (APC), polypectomy,

  13. The renaissance of complement therapeutics

    Science.gov (United States)

    Ricklin, Daniel; Mastellos, Dimitrios C.; Reis, Edimara S.; Lambris, John D.

    2018-01-01

    The increasing number of clinical conditions that involve a pathological contribution from the complement system — many of which affect the kidneys — has spurred a regained interest in therapeutic options to modulate this host defence pathway. Molecular insight, technological advances, and the first decade of clinical experience with the complement-specific drug eculizumab, have contributed to a growing confidence in therapeutic complement inhibition. More than 20 candidate drugs that target various stages of the complement cascade are currently being evaluated in clinical trials, and additional agents are in preclinical development. Such diversity is clearly needed in view of the complex and distinct involvement of complement in a wide range of clinical conditions, including rare kidney disorders, transplant rejection and haemodialysis-induced inflammation. The existing drugs cannot be applied to all complement-driven diseases, and each indication has to be assessed individually. Alongside considerations concerning optimal points of intervention and economic factors, patient stratification will become essential to identify the best complement-specific therapy for each individual patient. This Review provides an overview of the therapeutic concepts, targets and candidate drugs, summarizes insights from clinical trials, and reflects on existing challenges for the development of complement therapeutics for kidney diseases and beyond. PMID:29199277

  14. ELECTRICAL EQUIVALENT CIRCUIT OF BIOLOGICAL OBJECTS OF VEGETABLE

    Directory of Open Access Journals (Sweden)

    I. M. Golev

    2014-01-01

    Full Text Available Summary.The results of measurements of complex biological tissues electrical resistance of vegetable origin are presented. The measurements were performed at T=296 K in the frequency range from 5 to 500 kHz. As the electrodes were covered with tin (purity of 99.9% copper plates.. Experimentally investigated the following objects: samples parenchymal tissue of Apple in the form of cylinders with a diameter of 20 mm and a length of 20 mm; Apple juice, obtained by mechanical destruction of cells; pressed Apple pulp (juice content of not more than 20%obtained by the centrifugal separation, which destroyed the system of cells. For plant tissue with a holistic system of cells in the field 103 - 105 Hz is observed pronounced minimum angle of phase shift. In the absence of cells and its value is greatly reduced .The equivalent electrical circuit fabrics are considered. The calculation of all its elements is made. The equivalent capacitance of the electrical double layer at the interface of metal measuring electrode and extracellular fluid is element of C1 . The electrical resistance of this layer alternating current is characterized by the element R1 . Chain parallel connected resistance and capacitance describes the system of plant cells. The capacitance C2 is due to the electrical capacity of the cell membranes, and the resistance R2 is the electrical resistance of the membranes and intracellular space.The coincidence of experimental and calculated data in a frequency range of more than 103 Hz satisfactory. In the region of lower frequencies is observed differences. This may be due to the specific behavior of the electrical double layer. However, in the frequency region where the electrical properties of the cell structure of the investigated tissue match good, which proves the validity of the considered equivalent circuit. It is shown that the value of the complex electrical impedance of vegetable tissue in the frequency range from 103 Hz to 105

  15. Spatial estimates of snow water equivalent in the Sierra Nevada

    Science.gov (United States)

    Rittger, Karl Eric

    The spatial distribution of snow and its melt over large river basins cannot be directly observed, complicating decisions for competing priorities of flood protection and resource use. This work aims to advance our ability to estimate snow distribution through improvements in the satellite observation of snow-covered area (SCA) and the modeling of snow water equivalent (SWE). I analyze the accuracies of three methods to map SCA from MODIS, a binary and a fractional method (MOD10A1) based on the normalized difference snow index (NDSI), and another fractional method based on spectral mixture analyses, MODSCAG. I find that fractional SCA estimates from MODSCAG perform best over a range of snow and vegetation conditions and the model maintains its retrieval ability in the transitional periods during accumulation and melt. Forest obstructs viewable snow cover, and satellite-viewing geometry has a larger effect on the fractional NDSI-based approach than MODSCAG. Adjustments to SCA to account for forest canopies permit MODSCAG to perform very well in all but the densest canopies while MOD10A1 shows early melt out, when compared with ground sensors, in sparse to moderately dense canopy. Combining satellite observed SCA and albedo with an energy balance model, I estimate spatially distributed snow water equivalent for 12 years in the Sierra Nevada. The model shows that the relationship of SWE with elevation is significantly different for wet, mean and dry years, between drainages and at different latitudes. SWE and SCA become increasingly correlated from March 1st to July 1st, such that real time SCA observations may be sufficient for SWE prediction. I compare spatially integrated volumes of snow water equivalent from this model and two real-time models with full natural flow estimates in 18 Sierra Nevada basins covering 70% of the streamflow range in the last 80 years. Forecasting errors that are based on statistical relationships between point measurements of snow and

  16. An equivalent fluid/equivalent medium approach for the numerical simulation of coastal landslides propagation: theory and case studies

    Directory of Open Access Journals (Sweden)

    P. Mazzanti

    2009-11-01

    Full Text Available Coastal and subaqueous landslides can be very dangerous phenomena since they are characterised by the additional risk of induced tsunamis, unlike their completely-subaerial counterparts. Numerical modelling of landslides propagation is a key step in forecasting the consequences of landslides. In this paper, a novel approach named Equivalent Fluid/Equivalent Medium (EFEM has been developed. It adapts common numerical models and software that were originally designed for subaerial landslides in order to simulate the propagation of combined subaerial-subaqueous and completely-subaqueous landslides. Drag and buoyancy forces, the loss of energy at the landslide-water impact and peculiar mechanisms like hydroplaning can be suitably simulated by this approach; furthermore, the change in properties of the landslide's mass, which is encountered at the transition from the subaerial to the submerged environment, can be taken into account. The approach has been tested by modelling two documented coastal landslides (a debris flow and a rock slide at Lake Albano using the DAN-W code. The results, which were achieved from the back-analyses, demonstrate the efficacy of the approach to simulate the propagation of different types of coastal landslides.

  17. Monte Carlo study of neutron dose equivalent during passive scattering proton therapy

    Science.gov (United States)

    Zheng, Yuanshui; Newhauser, Wayne; Fontenot, Jonas; Taddei, Phil; Mohan, Radhe

    2007-08-01

    Stray radiation exposures are of concern for patients receiving proton radiotherapy and vary strongly with several treatment factors. The purposes of this study were to conservatively estimate neutron exposures for a contemporary passive scattering proton therapy system and to understand how they vary with treatment factors. We studied the neutron dose equivalent per therapeutic absorbed dose (H/D) as a function of treatment factors including proton energy, location in the treatment room, treatment field size, spread-out Bragg peak (SOBP) width and snout position using both Monte Carlo simulations and analytical modeling. The H/D value at the isocenter for a 250 MeV medium field size option was estimated to be 20 mSv Gy-1. H/D values generally increased with the energy or penetration range, fell off sharply with distance from the treatment unit, decreased modestly with the aperture size, increased with the SOBP width and decreased with the snout distance from the isocenter. The H/D values from Monte Carlo simulations agreed well with experimental results from the literature. The analytical model predicted H/D values within 28% of those obtained in simulations; this value is within typical neutron measurement uncertainties.

  18. Assessment of organ equivalent doses and effective doses from diagnostic X-ray examinations

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sang Hyun

    2003-02-15

    The MIRD-type adult male, female and age 10 phantoms were constructed to evaluate organ equivalent dose and effective dose of patient due to typical diagnostic X-ray examination. These phantoms were constructed with external and internal dimensions of Korean. The X-ray energy spectra were generated with SPEC78. MCNP4B ,the general-purposed Monte Carlo code, was used. Information of chest PA , chest LAT, and abdomen AP diagnostic X-ray procedures was collected on the protocol of domestic hospitals. The results showed that patients pick up approximate 0.02 to 0.18 mSv of effective dose from a single chest PA examination, and 0.01 to 0.19 mSv from a chest LAT examination depending on the ages. From an abdomen AP examination, patients pick up 0.17 to 1.40 mSv of effective dose. Exposure time, organ depth from the entrance surface and X-ray beam field coverage considerably affect the resulting doses. Deviation among medical institutions is somewhat high, and this indicated that medical institutions should interchange their information and the need of education for medical staff. The methodology and the established system can be applied, with some expansion, to dose assessment for other medical procedures accompanying radiation exposure of patients like nuclear medicine or therapeutic radiology.

  19. Telepsychotherapy and the Therapeutic Relationship: Principles, Advantages, and Case Examples.

    Science.gov (United States)

    Kocsis, Barbara J; Yellowlees, Peter

    2017-08-24

    As the use of technology continues to expand within our mental healthcare system, there has been an increasing interest in conducting psychotherapy online using videoconferencing. Literature pertaining to telepsychotherapy has explored possible drawbacks of this modality on the therapeutic relationship, although several studies have shown that the efficacy of online psychotherapy is equivalent to in-person approaches. Little is written about the potential advantages to the psychotherapeutic relationship when psychotherapy is carried out over videoconferencing. The available literature was reviewed, as were the general principles of telepsychotherapy and the therapeutic relationship, followed by a more in-depth consideration of patient populations for whom telepsychotherapy may offer distinct advantages. The current literature, as well as our own clinical experience, suggests that telepsychotherapy may be effective for a broad range of patients, and it may offer distinct advantages in the building of a trusting psychotherapeutic relationship. Telepsychotherapy offers a novel way to reach and form strong psychotherapeutic relationships with many different types of patients, and it may foster therapeutic intimacy in ways that in-person psychotherapy cannot. More research is needed to further explore this unique modality.

  20. The equivalency between logic Petri workflow nets and workflow nets.

    Science.gov (United States)

    Wang, Jing; Yu, ShuXia; Du, YuYue

    2015-01-01

    Logic Petri nets (LPNs) can describe and analyze batch processing functions and passing value indeterminacy in cooperative systems. Logic Petri workflow nets (LPWNs) are proposed based on LPNs in this paper. Process mining is regarded as an important bridge between modeling and analysis of data mining and business process. Workflow nets (WF-nets) are the extension to Petri nets (PNs), and have successfully been used to process mining. Some shortcomings cannot be avoided in process mining, such as duplicate tasks, invisible tasks, and the noise of logs. The online shop in electronic commerce in this paper is modeled to prove the equivalence between LPWNs and WF-nets, and advantages of LPWNs are presented.

  1. Equivalent dose rate by muons to the human body.

    Science.gov (United States)

    Băcioiu, I

    2011-11-01

    In this paper, the relative sensitivity from different human tissues of the human body, at a ground level, from muon cosmic radiation has been studied. The aim of this paper was to provide information on the equivalent dose rates received from atmospheric muons to human body, at the ground level. The calculated value of the effective dose rate by atmospheric muons plus the radiation levels of the natural annual background radiation dose, at the ground level, in the momentum interval of cosmic ray muon (0.2-120.0 GeV/c) is about 2.106±0.001 mSv/y, which is insignificant in comparison with the values of the doses from the top of the atmosphere.

  2. On Equivalence of Nonequilibrium Thermodynamic and Statistical Entropies

    Directory of Open Access Journals (Sweden)

    Purushottam D. Gujrati

    2015-02-01

    Full Text Available We review the concept of nonequilibrium thermodynamic entropy and observables and internal variables as state variables, introduced recently by us, and provide a simple first principle derivation of additive statistical entropy, applicable to all nonequilibrium states by treating thermodynamics as an experimental science. We establish their numerical equivalence in several cases, which includes the most important case when the thermodynamic entropy is a state function. We discuss various interesting aspects of the two entropies and show that the number of microstates in the Boltzmann entropy includes all possible microstates of non-zero probabilities even if the system is trapped in a disjoint component of the microstate space. We show that negative thermodynamic entropy can appear from nonnegative statistical entropy.

  3. The Thermodynamical Arrow and the Historical Arrow; Are They Equivalent?

    Directory of Open Access Journals (Sweden)

    Martin Tamm

    2017-08-01

    Full Text Available In this paper, the relationship between the thermodynamic and historical arrows of time is studied. In the context of a simple combinatorial model, their definitions are made more precise and in particular strong versions (which are not compatible with time symmetric microscopic laws and weak versions (which can be compatible with time symmetric microscopic laws are given. This is part of a larger project that aims to explain the arrows as consequences of a common time symmetric principle in the set of all possible universes. However, even if we accept that both arrows may have the same origin, this does not imply that they are equivalent, and it is argued that there can be situations where one arrow may be well-defined but the other is not.

  4. Design Of Load-klystron Equivalent For Jlc

    CERN Document Server

    Grishanov, B I

    2004-01-01

    In this paper a design of a resistive load - an equivalent of a klystron for the Japan Linear Collider JLC is described. The load should operate in a pulse mode at high voltage and high averege power. Different design variants were considered. The choice in favour of ceramic bulk resistor with longitudinal conductivity was done. A caloric and hydraulic calculation was executed. A mesurements of ceramics thermal conductivity of the bulk resistor and of a single radiator produced warmth remooval were done. Unfortunataly the last events on JLC forbad us to realys the project "in metall". But authours houp that this design experience could be usefull for another accelerating centers. The load can find an application as a absorbing resistor in high voltage schemes.

  5. Preparation of a Three-Dimensional Full Thickness Skin Equivalent.

    Science.gov (United States)

    Reuter, Christian; Walles, Heike; Groeber, Florian

    2017-01-01

    In vitro test systems are a promising alternative to animal models. Due to the use of human cells in a three-dimensional arrangement that allows cell-cell or cell-matrix interactions these models may be more predictive for the human situation compared to animal models or two-dimensional cell culture systems. Especially for dermatological research, skin models such as epidermal or full-thickness skin equivalents (FTSE) are used for different applications. Although epidermal models provide highly standardized conditions for risk assessment, FTSE facilitate a cellular crosstalk between the dermal and epidermal layer and thus can be used as more complex models for the investigation of processes such as wound healing, skin development, or infectious diseases. In this chapter, we describe the generation and culture of an FTSE, based on a collagen type I matrix and provide troubleshooting tips for commonly encountered technical problems.

  6. On the order equivalence relation of binary association measures

    Directory of Open Access Journals (Sweden)

    Paradowski Mariusz

    2015-09-01

    Full Text Available Over a century of research has resulted in a set of more than a hundred binary association measures. Many of them share similar properties. An overview of binary association measures is presented, focused on their order equivalences. Association measures are grouped according to their relations. Transformations between these measures are shown, both formally and visually. A generalization coefficient is proposed, based on joint probability and marginal probabilities. Combining association measures is one of recent trends in computer science. Measures are combined in linear and nonlinear discrimination models, automated feature selection or construction. Knowledge about their relations is particularly important to avoid problems of meaningless results, zeroed generalized variances, the curse of dimensionality, or simply to save time

  7. Strength Estimation of Die Cast Beams Considering Equivalent Porous Defects

    Energy Technology Data Exchange (ETDEWEB)

    Park, Moon Shik [Hannam Univ., Daejeon (Korea, Republic of)

    2017-05-15

    As a shop practice, a strength estimation method for die cast parts is suggested, in which various defects such as pores can be allowed. The equivalent porosity is evaluated by combining the stiffness data from a simple elastic test at the part level during the shop practice and the theoretical stiffness data, which are defect free. A porosity equation is derived from Eshelby's inclusion theory. Then, using the Mori-Tanaka method, the porosity value is used to draw a stress-strain curve for the porous material. In this paper, the Hollomon equation is used to capture the strain hardening effect. This stress-strain curve can be used to estimate the strength of a die cast part with porous defects. An elastoplastic theoretical solution is derived for the three-point bending of a die cast beam by using the plastic hinge method as a reference solution for a part with porous defects.

  8. Noise Equivalent Power of Graphene-Superconductor-Based Optical Sensor

    Science.gov (United States)

    Aghda, B. Afkhami; Moftakharzadeh, A.; Hosseini, M.

    In this paper, the noise equivalent power (NEP) of optical sensors based on graphene-superconductor junctions in the voltage bias operation mode has been calculated. The effects of device parameters such as temperature, magnetic field and device resistance on the NEP of these detectors have been thoroughly investigated. By solving the related equations, graphene specific heat, thermal conductivity, electron-phonon interaction and responsivity of the detector have been obtained. Using the calculated parameters, the NEP of the device was obtained. The results show that at constant magnetic field the NEP will increase linearly by increasing device temperature. On the other hand, at constant temperature the behavior of NEP versus magnetic field is first increasing and then decreasing. Our calculations show that the optimal resistance of the device has a direct relation with respect to the device temperature, while in the investigated operating range the optimal resistance of device is almost independent of the magnetic field.

  9. Equivalence of Quantum Heat Machines, and Quantum-Thermodynamic Signatures

    Directory of Open Access Journals (Sweden)

    Raam Uzdin

    2015-09-01

    Full Text Available Quantum heat engines (QHE are thermal machines where the working substance is a quantum object. In the extreme case, the working medium can be a single particle or a few-level quantum system. The study of QHE has shown a remarkable similarity with macroscopic thermodynamical results, thus raising the issue of what is quantum in quantum thermodynamics. Our main result is the thermodynamical equivalence of all engine types in the quantum regime of small action with respect to Planck’s constant. They have the same power, the same heat, and the same efficiency, and they even have the same relaxation rates and relaxation modes. Furthermore, it is shown that QHE have quantum-thermodynamic signature; i.e., thermodynamic measurements can confirm the presence of quantum effects in the device. We identify generic coherent and stochastic work extraction mechanisms and show that coherence enables power outputs that greatly exceed the power of stochastic (dephased engines.

  10. Microscope - A space mission to test the equivalence principle

    Science.gov (United States)

    List, Meike; Selig, Hanns; Bremer, Stefanie; Lämmerzahl, Claus

    2010-01-01

    MICROSCOPE is a ESA/CNES space mission for testing the validity of the weak equivalence principle. The mission's goal is to determine the Eötvös parameter η with an accuracy of 10-15. The French space agency CNES is responsible for designing the satellite which is developed and produced within the Myriade series. The satellite's payload T-SAGE (Twin Space Accelerometer for Gravitation Experimentation) consists of two high-precision capacitive differential accelerometers and is developed and built by the French institute ONERA. As a member of the MICROSCOPE performance team, the German department ZARM performs free fall tests of the MICROSCOPE differential accelerometers at the Bremen drop tower. The project's concepts and current results of the free fall tests are shortly presented.

  11. Space-Time Foam may Violate the Principle of Equivalence

    CERN Document Server

    Ellis, Jonathan Richard; Nanopoulos, Dimitri V; Sakharov, Alexander S; Ellis, John

    2004-01-01

    The interactions of different particle species with the foamy space-time fluctuations expected in quantum gravity theories may not be universal, in which case different types of energetic particles may violate Lorentz invariance by varying amounts, violating the equivalence principle. We illustrate this possibility in two different models of space-time foam based on D-particle fluctuations in either flat Minkowski space or a stack of intersecting D-branes. Both models suggest that Lorentz invariance could be violated for energetic particles that do not carry conserved charges, such as photons, whereas charged particles such electrons would propagate in a Lorentz-inavariant way. The D-brane model further suggests that gluon propagation might violate Lorentz invariance, but not neutrinos. We argue that these conclusions hold at both the tree (lowest-genus) and loop (higher-genus) levels, and discuss their implications for the phenomenology of quantum gravity.

  12. Equivalence-principle Analog of the Gravitational Redshift

    CERN Document Server

    Arms, K

    2016-01-01

    What happens when two synchronized clocks on a rigid beam are both given the exact same acceleration profile? Will they remain synchronized? What if we use a rigid-rod Rindler acceleration profile? The special relativity prediction surprises many people. This experimental setup is the special-relativity analog of the gravitational redshift. Just like two clocks higher and lower in a gravitational field lose synchronization, one sees a loss of synchronization in these clocks with `identical' acceleration profiles. To the best of our knowledge this equivalence principle analog has never been directly measured, and current experimental techniques are sensitive enough to measure it. We discuss the origin of the essential physics behind this synchronization loss, and some special conditions which simplify its experimental observation. We discuss the origin of the essential physics behind this synchronization loss, and some special conditions which simplify its experimental observation. If validated this effect wil...

  13. The short-circuit concept used in field equivalence principles

    DEFF Research Database (Denmark)

    Appel-Hansen, Jørgen

    1990-01-01

    In field equivalence principles, electric and magnetic surface currents are specified and considered as impressed currents. Often the currents are placed on perfect conductors. It is shown that these currents can be treated through two approaches. The first approach is decomposition of the total...... field into partial fields caused by the individual impressed currents. When this approach is used, it is shown that, on a perfect electric (magnetic) conductor, impressed electric (magnetic) surface currents are short-circuited. The second approach is to note that, since Maxwell's equations...... and the boundary conditions are satisfied, none of the impressed currents is short-circuited and no currents are induced on the perfect conductors. Since all currents and field quantities are considered at the same time, this approach is referred to as the total-field approach. The partial-field approach leads...

  14. Experimental Evaluation of Equivalent-Fluid Models for Melamine Foam

    Science.gov (United States)

    Allen, Albert R.; Schiller, Noah H.

    2016-01-01

    Melamine foam is a soft porous material commonly used in noise control applications. Many models exist to represent porous materials at various levels of fidelity. This work focuses on rigid frame equivalent fluid models, which represent the foam as a fluid with a complex speed of sound and density. There are several empirical models available to determine these frequency dependent parameters based on an estimate of the material flow resistivity. Alternatively, these properties can be experimentally educed using an impedance tube setup. Since vibroacoustic models are generally sensitive to these properties, this paper assesses the accuracy of several empirical models relative to impedance tube measurements collected with melamine foam samples. Diffuse field sound absorption measurements collected using large test articles in a laboratory are also compared with absorption predictions determined using model-based and measured foam properties. Melamine foam slabs of various thicknesses are considered.

  15. The concept of hemoglobin equivalency of perfluorochemical emulsions.

    Science.gov (United States)

    Faithfull, N Simon

    2003-01-01

    Perfluorochemical (PFC) emulsions have been in development as intravenous oxygen carriers for a number of years and many publications have dealt with their oxygen transport characteristics in both experimental models and in clinical trials. Though it has been stressed on numerous occasions that PFCs deliver oxygen to the tissues in very different ways to those by which Hemoglobin (Hb) releases oxygen (O2), no serious attempts have been made to correlate the oxygen delivery capacity of PFCs to those of Hb. This paper presents theoretical ways in which this can be done and demonstrates that a 2.7 g/kg dose of PFC is approximately equivalent to 4 g/dL [Hb]. Clinical trial planning is discussed.

  16. Testing Einstein's Equivalence Principle With Fast Radio Bursts.

    Science.gov (United States)

    Wei, Jun-Jie; Gao, He; Wu, Xue-Feng; Mészáros, Peter

    2015-12-31

    The accuracy of Einstein's equivalence principle (EEP) can be tested with the observed time delays between correlated particles or photons that are emitted from astronomical sources. Assuming as a lower limit that the time delays are caused mainly by the gravitational potential of the Milky Way, we prove that fast radio bursts (FRBs) of cosmological origin can be used to constrain the EEP with high accuracy. Taking FRB 110220 and two possible FRB/gamma-ray burst (GRB) association systems (FRB/GRB 101011A and FRB/GRB 100704A) as examples, we obtain a strict upper limit on the differences of the parametrized post-Newtonian parameter γ values as low as [γ(1.23  GHz)-γ(1.45  GHz)]GRBs.

  17. Equivalent Culture-Anchored Units Translation? The Phraseological Units Issue

    Directory of Open Access Journals (Sweden)

    Maciej Paweł Jaskot

    2016-12-01

    Full Text Available Equivalent Culture-Anchored Units Translation? The Phraseological Units Issue This article examines a question that has been of long-standing interest to linguists working in the fields of cross-linguistic phraseology and the translation of idiosyncratic language units, such as phraseological units (PUs. The challenge of translating PUs, which are understood as "patterns sanctioned by a given culture", involves the translation of culturemes. Therefore, a good translator must be able to assess the importance of the elements containing cultural references in the source language while "moving" them to the target language. When translating PUs, it is desirable that interlingual (cross-linguistic equivalence be achieved. The fact that translations of a PU can be very different (the translator can paraphrase the text, creatively change it, or simply eliminate the PU implies that the translational equivalence of PUs must be functional. While a cross-linguistic comparison (and the achievement of translational equivalence of PUs can be made by omitting the form parameter, it is desirable to preserve the extension and semantic structure, the connotative-pragmatic component, and the phrase combinatorics.   Ekwiwalencja jedostek "kulturowo zakotwiczonych"? Kwestia jednostek frazeologicznych Artykuł porusza zagadnienie, które od kilkudziesięciu lat cieszy się zainteresowaniem językoznawców zajmujących się konfrontacją językową frazeologii oraz tłumaczeniem idiosynkratycznych jednostek językowych, takich jak jednostki frazeologiczne (JF. Wyzwaniem podczas tłumaczenia JF, rozumianych jako "wzorce sankcjonowane przez daną kulturę", jawi się konieczność tłumaczenia kulturemów. Tłumacz zatem stoi w obliczu konieczności prawidłowej oceny danego elementu pod względem jego odniesień kulturowych w języku źródłowym podczas przekładania JF na język docelowy. Podczas tłumaczenia JF pożądane jest osiągnięcie międzyjęzykowej (cross

  18. Searching for cosmological signatures of the Einstein equivalence principle breaking

    Science.gov (United States)

    Holanda, R. F. L.; Barros, K. N. N. O.

    2016-07-01

    Modifications of gravity generated by a multiplicative coupling of a scalar field to the electromagnetic Lagrangian lead to a breaking of the Einstein equivalence principle (EEPB), as well as to variations of fundamental constants. In these theoretical frameworks, deviations of standard values of the fine structure constant, Δ α /α =ϕ , and of the cosmic distance duality relation, DL(1 +z )-2/DA=η =1 , where DL and DA are the luminosity and angular diameter distances, respectively, are unequivocally linked. In this paper, we search for cosmological signatures of the EEPB by using angular diameter distance from galaxy clusters, obtained via their Sunyaev-Zel'dovich effect (SZE) and x-ray observations, and distance modulus of type Ia supernovae (SNe Ia). The crucial point here is that we take into account the dependence of the SZE/x-ray technique with ϕ and η . Our new results show no indication of the EEPB.

  19. Equivalence of two contour prescriptions in superstring perturbation theory

    Energy Technology Data Exchange (ETDEWEB)

    Sen, Ashoke [Harish-Chandra Research Institute, Chhatnag Road, Jhusi, Allahabad 211019 (India); Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400085 (India); School of Physics, Korea Institute for Advanced Study,Seoul 130-722 (Korea, Republic of)

    2017-04-05

    Conventional superstring perturbation theory based on the world-sheet approach gives divergent results for the S-matrix whenever the total center of mass energy of the incoming particles exceeds the threshold of production of any final state consistent with conservation laws. Two systematic approaches have been suggested for dealing with this difficulty. The first one involves deforming the integration cycles over the moduli space of punctured Riemann surfaces into complexified moduli space. The second one treats the amplitude as a sum of superstring field theory Feynman diagrams and deforms the integration contours over loop energies of the Feynman diagram into the complex plane. In this paper we establish the equivalence of the two prescriptions to all orders in perturbation theory. Since the second approach is known to lead to unitary amplitudes, this establishes the consistency of the first prescription with unitarity.

  20. Equivalence of two contour prescriptions in superstring perturbation theory

    Science.gov (United States)

    Sen, Ashoke

    2017-04-01

    Conventional superstring perturbation theory based on the world-sheet approach gives divergent results for the S-matrix whenever the total center of mass energy of the incoming particles exceeds the threshold of production of any final state consistent with conservation laws. Two systematic approaches have been suggested for dealing with this difficulty. The first one involves deforming the integration cycles over the moduli space of punctured Riemann surfaces into complexified moduli space. The second one treats the amplitude as a sum of superstring field theory Feynman diagrams and deforms the integration contours over loop energies of the Feynman diagram into the complex plane. In this paper we establish the equivalence of the two prescriptions to all orders in perturbation theory. Since the second approach is known to lead to unitary amplitudes, this establishes the consistency of the first prescription with unitarity.

  1. Equivalent dose determination using a quartz isothermal TL signal

    DEFF Research Database (Denmark)

    Vandenberghe, D.A.G.; Jain, Mayank; Murray, A.S.

    2009-01-01

    We report on further developments in the use of an isothermal thermoluminescence (ITL) signal for determining the equivalent dose (De) in unheated sedimentary quartz. In order to minimise sensitivity change during the first measurement, the ITL signal is measured at 270 °C following a preheat...... agreement with the expected burial dose in samples from a variety of depositional environments and ages. Our results suggest that measurement of the ITL signal at 270 °C enables the quartz 325 °C TL peak to be used for accurate dose measurements on a single aliquot. The signal allows dating over at least...... the same age range as the OSL signal, and it appears especially advantageous for application to quartz samples for which the OSL signal saturates below 500 Gy....

  2. Thévenin equivalent based static contingency assessment

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a method for static security assessment of a power system and a real time static security assessment system for assessing a power system, the power system having a plurality of generators, the plurality of generators being represented in the network by a plurality...... of voltage controlled nodes, wherein the method for static security assessment of the power system comprises receiving information of a present state of the power system, determining a Thevenin equivalent for each voltage controlled node, determining for each voltage controlled node on basis......, and evaluating the voltage angles to determine whether the network having at least one contingency admit a steady state. Also a method of providing information on a real time static security assessment of a power system is disclosed....

  3. Sexual selection enables long-term coexistence despite ecological equivalence.

    Science.gov (United States)

    M'Gonigle, Leithen K; Mazzucco, Rupert; Otto, Sarah P; Dieckmann, Ulf

    2012-04-26

    Empirical data indicate that sexual preferences are critical for maintaining species boundaries, yet theoretical work has suggested that, on their own, they can have only a minimal role in maintaining biodiversity. This is because long-term coexistence within overlapping ranges is thought to be unlikely in the absence of ecological differentiation. Here we challenge this widely held view by generalizing a standard model of sexual selection to include two ubiquitous features of populations with sexual selection: spatial variation in local carrying capacity, and mate-search costs in females. We show that, when these two features are combined, sexual preferences can single-handedly maintain coexistence, even when spatial variation in local carrying capacity is so slight that it might go unnoticed empirically. This theoretical study demonstrates that sexual selection alone can promote the long-term coexistence of ecologically equivalent species with overlapping ranges, and it thus provides a novel explanation for the maintenance of species diversity.

  4. Time-metric equivalence and dimension change under time reparameterizations.

    Science.gov (United States)

    Motter, Adilson E; Gelfert, Katrin

    2009-06-01

    We study the behavior of dynamical systems under time reparameterizations, which is important not only to characterize chaos in relativistic systems but also to probe the invariance of dynamical quantities. We first show that time transformations are locally equivalent to metric transformations, a result that leads to a transformation rule for all Lyapunov exponents on arbitrary Riemannian phase spaces. We then show that time transformations preserve the spectrum of generalized dimensions D_{q} except for the information dimension D1 , which, interestingly, transforms in a nontrivial way despite previous assertions of invariance. The discontinuous behavior at q=1 can be used to constrain and extend the formulation of the Kaplan-Yorke conjecture.

  5. A new equivalent circuit model for micro electroporation systems

    KAUST Repository

    Shagoshtasbi, Hooman

    2011-02-01

    Electroporation (EP) is a unique biotechnique in which intense electric pulses are applied on the cell membrane to temporarily generate nanoscale electropores and to increase the membrane permeability for the delivery of exogenous biomolecules or drugs. We propose a new equivalent circuit model with 8 electric components to predict the electrodynamic response of a micro EP system. As the permeability of the cell membrane increases, the membrane resistance decreases. The numerical simulations of the transmembrane current responses to different applied voltages (1∼6V) are consistent with the experimental results using HeLa cells. Besides, the transmembrane voltage as a function of applied voltages is determined as well. These transmembrane current and voltage responses can be extremely useful for the design of new generation of micro EP systems for transfection of large DNA molecules in the future. © 2011 IEEE.

  6. In search of a germ theory equivalent for chronic disease.

    Science.gov (United States)

    Egger, Garry

    2012-01-01

    The fight against infectious disease advanced dramatically with the consolidation of the germ theory in the 19th century. This focus on a predominant cause of infections (ie, microbial pathogens) ultimately led to medical and public health advances (eg, immunization, pasteurization, antibiotics). However, the resulting declines in infections in the 20th century were matched by a rise in chronic, noncommunicable diseases, for which there is no single underlying etiology. The discovery of a form of low-grade systemic and chronic inflammation ("metaflammation"), linked to inducers (broadly termed "anthropogens") associated with modern man-made environments and lifestyles, suggests an underlying basis for chronic disease that could provide a 21st-century equivalent of the germ theory.

  7. Energy distribution of projectile fragment particles in heavy ion therapeutic beam

    Energy Technology Data Exchange (ETDEWEB)

    Matsufuji, Naruhiro; Tomura, Hiromi; Futami, Yasuyuki [National Inst. of Radiological Sciences, Chiba (Japan)] [and others

    1998-03-01

    Production of fragment particles in a patient`s body is one of important problems for heavy charged particle therapy. It is required to know the yield and the energy spectrum for each fragment element - so called `beam quality` to understand the effect of therapeutic beam precisely. In this study, fragment particles produced by practical therapeutic beam of HIMAC were investigated with using tissue-equivalent material and a detector complex. From the results, fragment particles were well identified by difference of their atomic numbers and the beam quality was derived. Responses of the detectors in this energy region were also researched. (author)

  8. Testing for measurement equivalence of individuals’ left-right orientation

    Directory of Open Access Journals (Sweden)

    Wiebke Weber

    2011-04-01

    Full Text Available Subjective variables such as opinions, attitudes or preferences cannot be measured directly. Researchers have to rely on the answers people give in surveys, and whenever those answers shall be compared it is required that people answer these questions in the same way. Only then a concept can be used in different contexts. This paper deals with the measurement of the left-right concept: it analyses whether people make a distinction between a scale labelled 0 left and 10 right to one which is labelled 0 extreme left and 10 extreme right and tests whether the instrument is equivalent across groups. Following the three steps of invariance testing, configural, metric and scalar invariance, we find that the left-right response scale is on average equivalent across groups with different levels of political interest and different levels of education. This finding holds also in 23 of the 25 European countries tested, with the exception of the eastern part of Germany, Finland and France. In order to estimate how serious the difference between these two groups of countries is, we compare the observed means (which are affected by the difference to the latent means (which are free of those effects, and the effect of the observed variable “attitude towards government’s intervention in the economy” on the observed variable “left-right self-placement” with the effect between these variables after correcting for scale difference. It was found that countries’ means can be compared but that the relationship with other variables might not be comparable among East Germany, Finland, France and the remaining countries.

  9. The equivalent thermal properties of a single fracture

    Science.gov (United States)

    Adler, P. M.; Sangare, D.; Thovert, J. F.

    2009-04-01

    The major objective of this communication is to determine in a steady state the equivalent thermal resistance of a fracture embedded in a conducting medium when a constant temperature gradient is imposed far away from the fracture. This gradient is either perpendicular or parallel to the fracture plane. In the first situation, the fracture corresponds roughly to a layer of conductivity lambdaf in between two blocks with the same conductivity lambda; it is equivalent to an additional resistance (which can be negative) in series with the two solid blocks. In the second situation, the fracture corresponds to an element in parallel with the two solid blocks; therefore, it is more straightforward to study the tangential conductivity rather than the tangential resistance. These two quantities are systematically addressed. Of course, the thermal resistance is the inverse of the thermal conductivity and these quantities can be easily derived one from another. It is important to notice that this work is not limited to thermal problems, but to problems which are governed by Laplace equations in the fracture and in the surrounding solid. For instance, consider a fracture filled by debris embedded in a porous medium; the flow on the Darcy scale in these two media are governed by elliptic equations with different coefficients. Therefore, all the methodology and results apply to this case as well. The normal resistance and the tangential conductivity of a single fracture with Gaussian or self affine surfaces are systematically studied as functions of the nature of the materials in contact and of the geometrical parameters. Analytical formulae are provided in the lubrication limit for fractures with sinusoidal apertures; these formulae are used to substantiate empirical formulae for resistance and conductivity. Other approximations based on the combination of series and parallel formulae are tested.

  10. SWEAT: Snow Water Equivalent with AlTimetry

    Science.gov (United States)

    Agten, Dries; Benninga, Harm-Jan; Diaz Schümmer, Carlos; Donnerer, Julia; Fischer, Georg; Henriksen, Marie; Hippert Ferrer, Alexandre; Jamali, Maryam; Marinaci, Stefano; Mould, Toby JD; Phelan, Liam; Rosker, Stephanie; Schrenker, Caroline; Schulze, Kerstin; Emanuel Telo Bordalo Monteiro, Jorge

    2017-04-01

    To study how the water cycle changes over time, satellite and airborne remote sensing missions are typically employed. Over the last 40 years of satellite missions, the measurement of true water inventories stored in sea and land ice within the cryosphere have been significantly hindered by uncertainties introduced by snow cover. Being able to determine the thickness of this snow cover would act to reduce such error, improving current estimations of hydrological and climate models, Earth's energy balance (albedo) calculations and flood predictions. Therefore, the target of the SWEAT (Snow Water Equivalent with AlTimetry) mission is to directly measure the surface Snow Water Equivalent (SWE) on sea and land ice within the polar regions above 60°and below -60° latitude. There are no other satellite missions currently capable of directly measuring SWE. In order to achieve this, the proposed mission will implement a novel combination of Ka- and Ku-band radioaltimeters (active microwave sensors), capable of penetrating into the snow microstructure. The Ka-band altimeter (λ ≈ 0.8 cm) provides a low maximum snow pack penetration depth of up to 20 cm for dry snow at 37 GHz, since the volume scattering of snow dominates over the scattering caused by the underlying ice surface. In contrast, the Ku-band altimeter (λ ≈ 2 cm) provides a high maximum snowpack penetration depth of up to 15 m in high latitudes regions with dry snow, as volume scattering is decreased by a factor of 55. The combined difference in Ka- and Ku-band signal penetration results will provide more accurate and direct determination of SWE. Therefore, the SWEAT mission aims to improve estimations of global SWE interpreted from passive microwave products, and improve the reliability of numerical snow and climate models.

  11. On Asymptotically Lacunary Statistical Equivalent Sequences of Order α in Probability

    Directory of Open Access Journals (Sweden)

    Işık Mahmut

    2017-01-01

    Full Text Available In this study, we introduce and examine the concepts of asymptotically lacunary statistical equivalent of order α in probability and strong asymptotically lacunary equivalent of order α in probability. We give some relations connected to these concepts.

  12. On Asymptotically Lacunary Statistical Equivalent Sequences of Order α in Probability

    OpenAIRE

    Işık Mahmut; Akbaş Kübra Elif

    2017-01-01

    In this study, we introduce and examine the concepts of asymptotically lacunary statistical equivalent of order α in probability and strong asymptotically lacunary equivalent of order α in probability. We give some relations connected to these concepts.

  13. High School Equivalency Assessment and Recognition in the United States: An Eyewitness Account

    Science.gov (United States)

    McLendon, Lennox

    2017-01-01

    This chapter on high school equivalency describes recent events involved in updating the adult education high school equivalency assessment services and the entrance of additional assessments into the field.

  14. [Utilization of the nine equivalents of nursing manpower use score (NEMS) in a pediatric intensive care unit].

    Science.gov (United States)

    Monroy, J C; Hurtado Pardos, B

    2002-01-01

    In 1994, sponsored by the European Communities Commission and the FRICE (Foundation for Research on Intensive Care in Europe), the EURICUS proyect was born, which, among other objectives, sets out to know objectively the work loads of the nursing staff in the intensive medicine services. As a consequence, the FRICE developed and validated a new therapeutic index, the nine equivalents of nursing manpower use score, NEMS. This scale (NEMS) can determine the therapeutic effort required by critically ill patients in a simple way and only using nine therapeutic variables. The objectives of this study are: to know if the NEMS scale reflects the therapeutic effort of the pediatric critical patients and validate if the NEMS scale measures the health care effect of the nursing staff in a pediatric intensive care unit (PICU). The study was performed in the Pediatrics Intensive Care Unit of the Hospital Sant Joan de Déu in Barcelona. The population studied was made up by the patients admitted to the PICU during a three week period (January 17 to February 6, 2001). Eight nurses from the unit having different shifts participated in the data collection. The NEMS scale was measured at 7 am.m. and 7 p.m. respectively in all the patients and then a qualitative assessment of the data obtained was performed. During this period, there were 50 admissions in the unit: 2.2 admissiions per day. The occupancy rate during the days of the study was 75%. A total of 389 measurements were performed, obtaining a mean value of 26.1 on the NEMS scale. Principal contributions of the nurses participating in the study were:They believe that use of the health care effort scales is useful in the intensive care units. The NEMS scale is easy to use and requires little time to be filled out. The NEMS scale reflects the therapeutic effort of the pediatric critically ill patients, but does not reflect the nursing staff cares. In a pediatric ICU, the age of the patient who is hospitalized influences the

  15. Therapeutic approaches for celiac disease

    Science.gov (United States)

    Plugis, Nicholas M.; Khosla, Chaitan

    2015-01-01

    Celiac disease is a common, lifelong autoimmune disorder for which dietary control is the only accepted form of therapy. A strict gluten-free diet is burdensome to patients and can be limited in efficacy, indicating there is an unmet need for novel therapeutic approaches to supplement or supplant dietary therapy. Many molecular events required for disease pathogenesis have been recently characterized and inspire most current and emerging drug-discovery efforts. Genome-wide association studies (GWAS) confirm the importance of human leukocyte antigen genes in our pathogenic model and identify a number of new risk loci in this complex disease. Here, we review the status of both emerging and potential therapeutic strategies in the context of disease pathophysiology. We conclude with a discussion of how genes identified during GWAS and follow-up studies that enhance susceptibility may offer insight into developing novel therapies. PMID:26060114

  16. Therapeutic Dancing for Parkinson's Disease

    Directory of Open Access Journals (Sweden)

    Lorenna Pryscia Carvalho Aguiar

    2016-06-01

    Full Text Available Therapeutic dancing has been advocated as an effective adjunct to conventional physical therapies for people living with Parkinson's disease (PD. This systematic review evaluates studies on the outcomes of different dance genres on mobility and quality of life in PD. We searched databases including CINHAL (1982–2015, Medline (1922–2015, Scopus (1996–2015, Web of Science (2002–2015, Embase (2007–2015, PEDro (1999–2015 and the Cochrane Library (1996–2015. The key words were: Parkinson's disease, Parkinson*, Parkinsonism, dance, dance therapy, dance genres, safety, feasibility, and quality of life. Two independent investigators reviewed the texts. Only randomized controlled trials, quasirandomized controlled trials, and case series studies were included. There was emerging evidence that therapeutic dance can be safe and feasible for people with mild to moderately severe PD, with beneficial effects on walking, freezing of gait, and health related quality of life.

  17. Therapeutic drug monitoring: antiarrhythmic drugs

    OpenAIRE

    Campbell, T. J.; Williams, K. M.(Virginia Polytechnic Institute and State University, 24061, Blacksburg, VA, USA)

    1998-01-01

    Antiarrhythmic agents are traditionally classified according to Vaughan Williams into four classes of action. Class I antiarrhythmic agents include most of the drugs traditionally thought of as antiarrhythmics, and have as a common action, blockade of the fast-inward sodium channel on myocardium. These agents have a very significant toxicity, and while they are being used less, therapeutic drug monitoring (TDM) does significantly increase the safety with which they can be administered. Class ...

  18. Potential Therapeutic Effects of Psilocybin.

    Science.gov (United States)

    Johnson, Matthew W; Griffiths, Roland R

    2017-07-01

    Psilocybin and other 5-hydroxytryptamine2A agonist classic psychedelics have been used for centuries as sacraments within indigenous cultures. In the mid-twentieth century they were a focus within psychiatry as both probes of brain function and experimental therapeutics. By the late 1960s and early 1970s these scientific inquires fell out of favor because classic psychedelics were being used outside of medical research and in association with the emerging counter culture. However, in the twenty-first century, scientific interest in classic psychedelics has returned and grown as a result of several promising studies, validating earlier research. Here, we review therapeutic research on psilocybin, the classic psychedelic that has been the focus of most recent research. For mood and anxiety disorders, three controlled trials have suggested that psilocybin may decrease symptoms of depression and anxiety in the context of cancer-related psychiatric distress for at least 6 months following a single acute administration. A small, open-label study in patients with treatment-resistant depression showed reductions in depression and anxiety symptoms 3 months after two acute doses. For addiction, small, open-label pilot studies have shown promising success rates for both tobacco and alcohol addiction. Safety data from these various trials, which involve careful screening, preparation, monitoring, and follow-up, indicate the absence of severe drug-related adverse reactions. Modest drug-related adverse effects at the time of medication administration are readily managed. US federal funding has yet to support therapeutic psilocybin research, although such support will be important to thoroughly investigate efficacy, safety, and therapeutic mechanisms.

  19. Thermodynamic aspects of therapeutic hypothermia.

    Science.gov (United States)

    Vanlandingham, Sean C; Kurz, Michael C; Wang, Henry E

    2015-01-01

    Therapeutic hypothermia (TH) is an important treatment for post-cardiac arrest syndrome. Despite its widespread practice, only limited data describe the thermodynamic aspects of heat transfer during TH. This paper reviews the principles of human body heat balance and provides a conceptual model for characterizing heat exchange during TH. The model may provide a framework for computer simulation for improving training in or clinical methods of TH. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  20. Therapeutic advances in muscular dystrophy

    OpenAIRE

    Leung, Doris G; Wagner, Kathryn R

    2013-01-01

    The muscular dystrophies comprise a heterogeneous group of genetic disorders that produce progressive skeletal muscle weakness and wasting. There has been rapid growth and change in our understanding of these disorders in recent years, and advances in basic science are being translated into increasing numbers of clinical trials. This review will discuss therapeutic developments in 3 of the most common forms of muscular dystrophy: Duchenne muscular dystrophy, facioscapulohumeral muscular dystr...

  1. Avian Diagnostic and Therapeutic Antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, David Sherman [UND SMHS

    2012-12-31

    A number of infectious agents have the potential of causing significant clinical symptomology and even death, but dispite this, the number of incidence remain below the level that supports producing a vaccine. Therapeutic antibodies provide a viable treatment option for many of these diseases. We proposed that antibodies derived from West Nile Virus (WNV) immunized geese would be able to treat WNV infection in mammals and potential humans. We demonstrated that WNV specific goose antibodies are indeed successful in treating WNV infection both prophylactically and therapeutically in a golden hamster model. We demonstrated that the goose derived antibodies are non-reactogenic, i.e. do not cause an inflammatory response with multiple exposures in mammals. We also developed both a specific pathogen free facility to house the geese during the antibody production phase and a patent-pending purification process to purify the antibodies to greater than 99% purity. Therefore, the success of these study will allow a cost effective rapidly producible therapeutic toward clinical testing with the necessary infrastructure and processes developed and in place.

  2. Therapeutic Applications of Carbon Monoxide

    Science.gov (United States)

    Knauert, Melissa; Vangala, Sandeep; Haslip, Maria; Lee, Patty J.

    2013-01-01

    Heme oxygenase-1 (HO-1) is a regulated enzyme induced in multiple stress states. Carbon monoxide (CO) is a product of HO catalysis of heme. In many circumstances, CO appears to functionally replace HO-1, and CO is known to have endogenous anti-inflammatory, anti-apoptotic, and antiproliferative effects. CO is well studied in anoxia-reoxygenation and ischemia-reperfusion models and has advanced to phase II trials for treatment of several clinical entities. In alternative injury models, laboratories have used sepsis, acute lung injury, and systemic inflammatory challenges to assess the ability of CO to rescue cells, organs, and organisms. Hopefully, the research supporting the protective effects of CO in animal models will translate into therapeutic benefits for patients. Preclinical studies of CO are now moving towards more complex damage models that reflect polymicrobial sepsis or two-step injuries, such as sepsis complicated by acute respiratory distress syndrome. Furthermore, co-treatment and post-treatment with CO are being explored in which the insult occurs before there is an opportunity to intervene therapeutically. The aim of this review is to discuss the potential therapeutic implications of CO with a focus on lung injury and sepsis-related models. PMID:24648866

  3. Conotoxins: Therapeutic Potential and Application

    Directory of Open Access Journals (Sweden)

    Richard T. Layer

    2006-04-01

    Full Text Available The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides. Most conotoxins characterized to date target receptors and ion channels of excitable tissues, such as ligandgated nicotinic acetylcholine, N-methyl-D-aspartate, and type 3 serotonin receptors, as well as voltage-gated calcium, sodium, and potassium channels, and G-protein-coupled receptors including α-adrenergic, neurotensin, and vasopressin receptors, and the norepinephrine transporter. Several conotoxins have shown promise in preclinical models of pain, convulsive disorders, stroke, neuromuscular block, and cardioprotection. The pharmacological selectivity of the conotoxins, coupled with the safety and efficacy demonstrated in preclinical models, has led to their investigation as human therapeutic agents. In the following review, we will survey the pharmacology and therapeutic rationale of those conotoxins with potential clinical application, and discuss the unique challenges that each will face in the course of their transition from venom component to human therapeutic.

  4. Equivalence after extension and matricial coupling coincide with Schur coupling, on separable Hilbert spaces.

    NARCIS (Netherlands)

    Ran, A.C.M.; ter Horst, S.

    2014-01-01

    It is known that two Banach space operators that are Schur coupled are also equivalent after extension, or equivalently, matricially coupled. The converse implication, that operators which are equivalent after extension or matricially coupled are also Schur coupled, was only known for Fredholm

  5. 20 CFR 416.926 - Medical equivalence for adults and children.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Medical equivalence for adults and children... INCOME FOR THE AGED, BLIND, AND DISABLED Determining Disability and Blindness Medical Considerations § 416.926 Medical equivalence for adults and children. (a) What is medical equivalence? Your impairment...

  6. 42 CFR 440.340 - Actuarial report for benchmark-equivalent coverage.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Actuarial report for benchmark-equivalent coverage... AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS SERVICES: GENERAL PROVISIONS Benchmark Benefit and Benchmark-Equivalent Coverage § 440.340 Actuarial report for benchmark-equivalent coverage. (a...

  7. 42 CFR 440.335 - Benchmark-equivalent health benefits coverage.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Benchmark-equivalent health benefits coverage. 440... HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS SERVICES: GENERAL PROVISIONS Benchmark Benefit and Benchmark-Equivalent Coverage § 440.335 Benchmark-equivalent health benefits coverage. (a...

  8. Assessment of the Relatedness of Equivalent Stimuli through a Semantic Differential

    Science.gov (United States)

    Bortoloti, Renato; de Rose, Julio C.

    2009-01-01

    If stimulus equivalence is a model of meaning, abstract stimuli should acquire the meaning of meaningful stimuli equivalent to them. In Experiment 1, college students matched faces expressing emotions to arbitrary pictures, forming three classes of equivalent stimuli, each comprising an emotional expression and three arbitrary pictures. Semantic…

  9. CERTAINTY EQUIVALENCE FOR DETERMINATION OF OPTIMAL FERTILIZER APPLICATION RATES WITH CARRY-OVER

    OpenAIRE

    Taylor, C. Robert

    1983-01-01

    This note demonstrates that a certain class of stochastic problems for determination of optimal fertilizer application rates in the presence of fertilizer carry-over can be simplified to static, certainly equivalent problems. Conditions required for certainty equivalence to hold are: (1) fertilizer carry-over is agronomically equivalent to applied fertilizer; and (2) some addition of fertilizer is optimal in every decision period.

  10. 10 CFR Appendix to Part 474 - Sample Petroleum-Equivalent Fuel Economy Calculations

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Sample Petroleum-Equivalent Fuel Economy Calculations..., DEVELOPMENT, AND DEMONSTRATION PROGRAM; PETROLEUM-EQUIVALENT FUEL ECONOMY CALCULATION Pt. 474, App. Appendix to Part 474—Sample Petroleum-Equivalent Fuel Economy Calculations Example 1: An electric vehicle is...

  11. 75 FR 22126 - Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods...

    Science.gov (United States)

    2010-04-27

    ... AGENCY Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods: Designation of One New Equivalent Method AGENCY: Environmental Protection Agency. ACTION: Notice of the designation of one new equivalent method for monitoring ambient air quality. SUMMARY: Notice is hereby given...

  12. 75 FR 9894 - Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods...

    Science.gov (United States)

    2010-03-04

    ... AGENCY Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods: Designation of One New Equivalent Method AGENCY: Environmental Protection Agency. ACTION: Notice of the designation of one new equivalent method for monitoring ambient air quality. SUMMARY: Notice is hereby given...

  13. 75 FR 30022 - Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods...

    Science.gov (United States)

    2010-05-28

    ... AGENCY Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods: Designation of One New Equivalent Method AGENCY: Environmental Protection Agency. ACTION: Notice of the designation of one new equivalent method for monitoring ambient air quality. SUMMARY: Notice is hereby given...

  14. 75 FR 45627 - Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods...

    Science.gov (United States)

    2010-08-03

    ... AGENCY Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods: Designation of One New Equivalent Method AGENCY: Environmental Protection Agency. ACTION: Notice of the designation of one new equivalent method for monitoring ambient air quality. SUMMARY: Notice is hereby given...

  15. 76 FR 62402 - Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods...

    Science.gov (United States)

    2011-10-07

    ... AGENCY Office of Research and Development; Ambient Air Monitoring Reference and Equivalent Methods; Designation of One New Equivalent Method AGENCY: Environmental Protection Agency. ACTION: Notice of the..., Research Triangle Park, North Carolina 27711. Designation of this new equivalent method is intended to...

  16. 45 CFR 162.1101 - Health care claims or equivalent encounter information transaction.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Health care claims or equivalent encounter... ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Health Care Claims or Equivalent Encounter Information § 162.1101 Health care claims or equivalent encounter information...

  17. 30 CFR 75.1101-12 - Equivalent dry-pipe system.

    Science.gov (United States)

    2010-07-01

    ... Equivalent dry-pipe system. Where water sprinkler systems are installed to protect main and secondary belt conveyor drives and freezing temperatures prevail, an equivalent dry-pipe system may be installed. ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Equivalent dry-pipe system. 75.1101-12 Section...

  18. Equivalent Dipole Vector Analysis for Detecting Pulmonary Hypertension

    Science.gov (United States)

    Harlander, Matevz; Salobir, Barbara; Toplisek, Janez; Schlegel, Todd T.; Starc, Vito

    2010-01-01

    Various 12-lead ECG criteria have been established to detect right ventricular hypertrophy as a marker of pulmonary hypertension (PH). While some criteria offer good specificity they lack sensitivity because of a low prevalence of positive findings in the PH population. We hypothesized that three-dimensional equivalent dipole (ED) model could serve as a better detection tool of PH. We enrolled: 1) 17 patients (12 female, 5 male, mean age 57 years, range 19-79 years) with echocardiographically detected PH (systolic pulmonary arterial pressure greater than 35 mmHg) and no significant left ventricular disease; and 2) 19 healthy controls (7 female, 12 male, mean age 44, range 31-53 years) with no known heart disease. In each subject we recorded a 5-minute high-resolution 12-lead conventional ECG and constructed principal signals using singular value decomposition. Assuming a standard thorax dimension of an adult person with homogenous and isotropic distribution of thorax conductance, we determined moving equivalent dipoles (ED), characterized by the 3D location in the thorax, dipolar strength and the spatial orientation, in time intervals of 5 ms. We used the sum of all ED vectors in the second half of the QRS complex to derive the amplitude of the right-sided ED vector (RV), if the orientation of ED was to the right side of the thorax, and in the first half the QRS to derive the amplitude of the left-sided vector (LV), if the orientation was leftward. Finally, the parameter RV/LV ratio was determined over an average of 256 complexes. The groups differed in age and gender to some extent. There was a non-significant trend toward higher RV in patients with PH (438 units 284) than in controls (280 plus or minus 140) (p = 0.066) but the overlap was such that RV alone was not a good predictor of PH. On the other hand, the RV/LV ratio was a better predictor of PH, with 11/17 (64.7%) of PH patients but only in 1/19 (5.3%) control subjects having RV/LV ratio greater than or

  19. MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure

    Energy Technology Data Exchange (ETDEWEB)

    Kosten, Ilona J.; Spiekstra, Sander W. [Department of Dermatology, VU University Medical Center, Amsterdam (Netherlands); Gruijl, Tanja D. de [Department of Dermatology Medical Oncology, VU University Medical Center, Amsterdam (Netherlands); Gibbs, Susan, E-mail: s.gibbs@acta.nl [Department of Dermatology, VU University Medical Center, Amsterdam (Netherlands); Department of Oral Cell Biology, Academic Center for Dentistry (ACTA), Amsterdam (Netherlands)

    2015-08-15

    After allergen or irritant exposure, Langerhans cells (LC) undergo phenotypic changes and exit the epidermis. In this study we describe the unique ability of MUTZ-3 derived Langerhans cells (MUTZ-LC) to display similar phenotypic plasticity as their primary counterparts when incorporated into a physiologically relevant full-thickness skin equivalent model (SE-LC). We describe differences and similarities in the mechanisms regulating LC migration and plasticity upon allergen or irritant exposure. The skin equivalent consisted of a reconstructed epidermis containing primary differentiated keratinocytes and CD1a{sup +} MUTZ-LC on a primary fibroblast-populated dermis. Skin equivalents were exposed to a panel of allergens and irritants. Topical exposure to sub-toxic concentrations of allergens (nickel sulfate, resorcinol, cinnamaldehyde) and irritants (Triton X-100, SDS, Tween 80) resulted in LC migration out of the epidermis and into the dermis. Neutralizing antibody to CXCL12 blocked allergen-induced migration, whereas anti-CCL5 blocked irritant-induced migration. In contrast to allergen exposure, irritant exposure resulted in cells within the dermis becoming CD1a{sup −}/CD14{sup +}/CD68{sup +} which is characteristic of a phenotypic switch of MUTZ-LC to a macrophage-like cell in the dermis. This phenotypic switch was blocked with anti-IL-10. Mechanisms previously identified as being involved in LC activation and migration in native human skin could thus be reproduced in the in vitro constructed skin equivalent model containing functional LC. This model therefore provides a unique and relevant research tool to study human LC biology in situ under controlled in vitro conditions, and will provide a powerful tool for hazard identification, testing novel therapeutics and identifying new drug targets. - Highlights: • MUTZ-3 derived Langerhans cells integrated into skin equivalents are fully functional. • Anti-CXCL12 blocks allergen-induced MUTZ-LC migration.

  20. Teacher ratings of ODD symptoms: measurement equivalence across Malaysian Malay, Chinese and Indian children.

    Science.gov (United States)

    Gomez, Rapson

    2014-04-01

    The study examined the measurement equivalence for teacher ratings across Malaysian Malay, Chinese and Indian children. Malaysian teachers completed ratings of the ODD symptoms for 574 Malay, 247 Chinese and 98 Indian children. The results supported the equivalences for the configural, metric, and error variances models, and the equivalences for ODD latent variances and mean scores. Together, these findings suggest good support for measurement and structural equivalences of the ODD symptoms across these ethnic groups. The theoretical and clinical implications of the findings for cross-cultural equivalence of the ODD symptoms are discussed. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Magnetic equivalent circuit model for unipolar hybrid excitation synchronous machine

    Directory of Open Access Journals (Sweden)

    Kupiec Emil

    2015-03-01

    Full Text Available Lately, there has been increased interest in hybrid excitation electrical machines. Hybrid excitation is a construction that combines permanent magnet excitation with wound field excitation. Within the general classification, these machines can be classified as modified synchronous machines or inductor machines. These machines may be applied as motors and generators. The complexity of electromagnetic phenomena which occur as a result of coupling of magnetic fluxes of separate excitation systems with perpendicular magnetic axis is a motivation to formulate various mathematical models of these machines. The presented paper discusses the construction of a unipolar hybrid excitation synchronous machine. The magnetic equivalent circuit model including nonlinear magnetization curves is presented. Based on this model, it is possible to determine the multi-parameter relationships between the induced voltage and magnetomotive force in the excitation winding. Particular attention has been paid to the analysis of the impact of additional stator and rotor yokes on above relationship. Induced voltage determines the remaining operating parameters of the machine, both in the motor and generator mode of operation. The analysis of chosen correlations results in an identification of the effective control range of electromotive force of the machine.

  2. Independent contrasts and PGLS regression estimators are equivalent.

    Science.gov (United States)

    Blomberg, Simon P; Lefevre, James G; Wells, Jessie A; Waterhouse, Mary

    2012-05-01

    We prove that the slope parameter of the ordinary least squares regression of phylogenetically independent contrasts (PICs) conducted through the origin is identical to the slope parameter of the method of generalized least squares (GLSs) regression under a Brownian motion model of evolution. This equivalence has several implications: 1. Understanding the structure of the linear model for GLS regression provides insight into when and why phylogeny is important in comparative studies. 2. The limitations of the PIC regression analysis are the same as the limitations of the GLS model. In particular, phylogenetic covariance applies only to the response variable in the regression and the explanatory variable should be regarded as fixed. Calculation of PICs for explanatory variables should be treated as a mathematical idiosyncrasy of the PIC regression algorithm. 3. Since the GLS estimator is the best linear unbiased estimator (BLUE), the slope parameter estimated using PICs is also BLUE. 4. If the slope is estimated using different branch lengths for the explanatory and response variables in the PIC algorithm, the estimator is no longer the BLUE, so this is not recommended. Finally, we discuss whether or not and how to accommodate phylogenetic covariance in regression analyses, particularly in relation to the problem of phylogenetic uncertainty. This discussion is from both frequentist and Bayesian perspectives.

  3. Mechanical equivalent of Bayesian inference from monitoring data

    Science.gov (United States)

    Cappello, Carlo; Bolognani, Denise; Zonta, Daniele

    2016-04-01

    Structural health monitoring requires engineers to understand the state of a structure from its observed response. When this information is uncertain, Bayesian probability theory provides a consistent framework for making inference. However, structural engineers are often unenthusiastic about Bayesian logic and prefer to make inference using heuristics. Herein we propose a quantitative method for logical inference based on a formal analogy between linear elastic mechanics and Bayesian inference with Gaussian variables. We start by discussing the estimation of a single parameter under the assumption that all of the uncertain quantities have a Gaussian distribution and that the relationship between the observations and the parameter is linear. With these assumptions, the analogy is stated as follows: the expected value of the considered parameter corresponds to the position of a bar with one degree of freedom and uncertain observations of the parameter are modelled as linear elastic springs placed in series or parallel. If we want to extend the analogy to multiple parameters, we simply have to express the potential energy of the mechanical system associated to the inference problem. The expected value of the parameters is then calculated by minimizing that potential energy. We conclude our contribution by presenting the application of mechanical equivalent to a real-life case study in which we seek the elongation trend of a cable belonging to Adige Bridge, a cable-stayed bridge located North of Trento, Italy.

  4. Metabolic equivalent determination in the cultural dance of hula.

    Science.gov (United States)

    Usagawa, T; Look, M; de Silva, M; Stickley, C; Kaholokula, J K; Seto, T; Mau, M

    2014-05-01

    Ethnic minorities share an unequal burden of cardiometabolic syndrome. Physical activity (PA) has been shown to be an important factor for improving the outcomes of these diseases. While metabolic equivalents (METs) have been calculated for diverse activities, most cultural activities have not been evaluated. Hula, the traditional dance of Native Hawaiians, is practiced by men and women of all ages but its MET value is unknown. To our knowledge, this is the first scientific evaluation of energy expenditure of hula. 19 competitive hula dancers performed 2 dance sets of low- and high-intensity hula. METs were measured with a portable indirect calorimetry device. Mean and standard deviations were calculated for all the variables. A 2-way ANOVA was conducted to identify differences for gender and intensity. The mean MET were 5.7 (range 3.17-9.77) and 7.55 (range 4.43-12.0) for low-intensity and high-intensity, respectively. There was a significant difference between intensities and no significant difference between genders. This study demonstrates that the energy expenditure of both low- and high-intensity hula met the recommended guidelines for moderate and vigorous intensity exercise, respectively, and that hula can be utilized as a prescribed PA. © Georg Thieme Verlag KG Stuttgart · New York.

  5. Proton scattering power of some tissue-equivalent plastics

    CERN Document Server

    Vasiliev, V N; Khaybullin, V G; Samarin, S I; Uglov, A S

    2010-01-01

    Proton scattering in some water and tissue equivalent phantom materials was measured to evaluate their simulation accuracy of water and respective human biological tissues. The measurements were performed on the medical facility of the ITEP synchrotron, proton energy was 219 MeV, a narrow beam was formed by a 3 mm collimator. A stack of plastic slabs was set closely to the collimator hole as a scatterer. Three types of Plastic Water (PW, PW LR and PW DT), lung, cortical bone, adipose and muscle plastics (CIRS Inc., USA) were used in the experiments as the substitutes under investigation and liquid water and PMMA slabs as reference materials. Dose (intensity) profiles were measured for each sample by two orthogonal strips of the Gafchromic EBT film. A total thickness of the plastic slab was from 4 to 16 cm depending on the material. The Gafchromic film response nonlinearity was taken into account by an additional calibration vs. absorbed dose in a wide proton beam, the temporal irradiation-to-scanning dependen...

  6. Dose equivalent to fingertips of nuclear medicine personnel

    Energy Technology Data Exchange (ETDEWEB)

    Olszewski, J.; Jankowski, J. [Institute of Occupational Medicine, Dept. of Radiation Protection Nofer (Poland); Jankowski, J.; Wrzesien, M. [Lodz Univ., Dept. of Nuclear Physics and Radiation Safety (Poland)

    2006-07-01

    One of the most frequently used diagnostic nuclear medicine procedures is done with 99 mTc radionuclides. Activities of radionuclides being administered may be even as high as 1 GBq. Medical personnel remain under constant dosimetric surveillance and are protected from radiation by using personal and permanent shields (like lead aprons, gloves or lead glass). Owing to this protection, effective doses are low, ranging within several per cent of the limit value. The situation is, however, quite different if one considers the exposure to hands of the personnel handling the radiopharmaceuticals. All isotope handling procedures, such as elution of technetium, preparation of radiopharmaceuticals or application of the latter to the patients are performed manually, with little use of manipulators. As a result, the dose to the hands during the handling of radioisotopes may be significant from the point of view of radiological protection. Our research leads to the following conclusions: 1. Fingertips of the middle finger, index and thumb are the most exposed to ionizing radiation parts of the hand. 2. The limit of the equivalent dose to the skin (500 mSv) may be exceeded, on the fingertips in particular. 3. The considerable dose reduction to hands exposed to ionizing radiation may be achieved by improving procedures through the work automation for example. (authors)

  7. Equivalence of cosmological observables in conformally related scalar tensor theories

    Science.gov (United States)

    Rondeau, François; Li, Baojiu

    2017-12-01

    Scalar tensor theories can be expressed in different frames, such as the commonly used Einstein and Jordan frames, and it is generally accepted that cosmological observables are the same in these frames. We revisit this by making a detailed side-by-side comparison of the quantities and equations in two conformally related frames, from the actions and fully covariant field equations to the linearized equations in both real and Fourier spaces. This confirms that the field and conservation equations are equivalent in the two frames, in the sense that we can always re-express equations in one frame using relevant transformations of variables to derive the corresponding equations in the other. We show, with both analytical derivation and a numerical example, that the line-of-sight integration to calculate CMB temperature anisotropies can be done using either Einstein frame or Jordan frame quantities, and the results are identical, provided the correct redshift is used in the Einstein frame (1 +z ≠1 /a ).

  8. Interdevice agreement of eight equivalent dental color measurement devices.

    Science.gov (United States)

    Weyhrauch, M; Igiel, C; Pabst, A M; Wentaschek, S; Scheller, H; Lehmann, K M

    2015-12-01

    The reproducibility of electronic color-measuring devices used in dentistry refers to the consistency of measurements of a single device and also that between identical devices. This in vitro study evaluated the short-term interdevice agreement of eight equivalent dental measurement devices. The short-term repeatability of eight identical VITA Easyshade Advance color measurement devices was evaluated. Each device was used to quantify the Commission Internationale de l'Eclairage (CIE) L*a*b* color coordinates of ceramic disks, designed in accordance with guidelines set by the VITA Toothguide 3D-Master shade tab organization. Statistical analysis involved calculating the intraclass correlation coefficients (ICCs) and color differences (ΔE*) for corresponding measurements taken by the devices. In addition, the mean color difference from the mean (MCDM) was calculated for each color. All devices showed high ICCs for the color coordinates (L = 0.996, a = 0.993, b = 0.999). The ΔE* by shade ranged from 0.62 to 1.67. The MCDM by color-measuring device ranged from 0.11 to 0.23. This in vitro study showed that the color-measuring devices used were suitable for determining shade with high repeatability. The high interdevice agreement of the VITA Easyshade Advance means that dental professionals can use this device independently, without compromising the consistency and quality of color measurements.

  9. Equivalence of interest rate models and lattice gases.

    Science.gov (United States)

    Pirjol, Dan

    2012-04-01

    We consider the class of short rate interest rate models for which the short rate is proportional to the exponential of a Gaussian Markov process x(t) in the terminal measure r(t)=a(t)exp[x(t)]. These models include the Black-Derman-Toy and Black-Karasinski models in the terminal measure. We show that such interest rate models are equivalent to lattice gases with attractive two-body interaction, V(t(1),t(2))=-Cov[x(t(1)),x(t(2))]. We consider in some detail the Black-Karasinski model with x(t) as an Ornstein-Uhlenbeck process, and show that it is similar to a lattice gas model considered by Kac and Helfand, with attractive long-range two-body interactions, V(x,y)=-α(e(-γ|x-y|)-e(-γ(x+y))). An explicit solution for the model is given as a sum over the states of the lattice gas, which is used to show that the model has a phase transition similar to that found previously in the Black-Derman-Toy model in the terminal measure.

  10. (Modular Effect Algebras are Equivalent to (Frobenius Antispecial Algebras

    Directory of Open Access Journals (Sweden)

    Dusko Pavlovic

    2017-01-01

    Full Text Available Effect algebras are one of the generalizations of Boolean algebras proposed in the quest for a quantum logic. Frobenius algebras are a tool of categorical quantum mechanics, used to present various families of observables in abstract, often nonstandard frameworks. Both effect algebras and Frobenius algebras capture their respective fragments of quantum mechanics by elegant and succinct axioms; and both come with their conceptual mysteries. A particularly elegant and mysterious constraint, imposed on Frobenius algebras to characterize a class of tripartite entangled states, is the antispecial law. A particularly contentious issue on the quantum logic side is the modularity law, proposed by von Neumann to mitigate the failure of distributivity of quantum logical connectives. We show that, if quantum logic and categorical quantum mechanics are formalized in the same framework, then the antispecial law of categorical quantum mechanics corresponds to the natural requirement of effect algebras that the units are each other's unique complements; and that the modularity law corresponds to the Frobenius condition. These correspondences lead to the equivalence announced in the title. Aligning the two formalisms, at the very least, sheds new light on the concepts that are more clearly displayed on one side than on the other (such as e.g. the orthogonality. Beyond that, it may also open up new approaches to deep and important problems of quantum mechanics (such as the classification of complementary observables.

  11. Evaluation of compositional equivalence for multitrait biotechnology crops.

    Science.gov (United States)

    Ridley, William P; Harrigan, George G; Breeze, Matthew L; Nemeth, Margaret A; Sidhu, Ravinder S; Glenn, Kevin C

    2011-06-08

    Compositional analysis is an important tool in the evaluation of the safety and nutritional status of biotechnology-derived crops. As part of the comparative assessment of a biotechnology-derived crop, its composition is evaluated by quantitative measurement of the levels of key nutrients, antinutrients, and secondary metabolites and compared to that of conventional crops. To evaluate the effect of combining multiple biotech traits through conventional breeding, the forage and grain compositions of the double combinations MON 810 × NK603, MON 863 × MON 810, and MON 863 × NK603 and the triple combination MON 863 × NK603 × MON 810 were compared to their respective near-isogenic, conventional control hybrids. Overall, a total of 241 statistical comparisons between the multitrait biotechnology crop and its corresponding conventional controls were conducted. Of these comparisons 192 (79.7%) were not statistically significantly different (p > 0.05), and all 49 of the differences were within the 99% tolerance interval for commercial hybrids grown in the same field or related field trials. These data on combined trait biotechnology-derived products demonstrated that the forage and grain were compositionally equivalent to their conventional comparators, indicating the absence of any influence of combining insect protection and herbicide tolerance traits by conventional breeding on compositional variation.

  12. Equivalent Electrical Circuits of Thermoelectric Generators under Different Operating Conditions

    Directory of Open Access Journals (Sweden)

    Saima Siouane

    2017-03-01

    Full Text Available Energy harvesting has become a promising and alternative solution to conventional energy generation patterns to overcome the problem of supplying autonomous electrical systems. More particularly, thermal energy harvesting technologies have drawn a major interest in both research and industry. Thermoelectric Generators (TEGs can be used in two different operating conditions, under constant temperature gradient or constant heat flow. The commonly used TEG electrical model, based on a voltage source in series with an electrical resistance, shows its limitations especially under constant heat flow conditions. Here, the analytical electrical modeling, taking into consideration the internal and contact thermal resistances of a TEG under constant temperature gradient and constant heat flow conditions, is first given. To give further insight into the electrical behavior of a TEG module in different operating conditions, we propose a new and original way of emulating the above analytical expressions with usual electronics components (voltage source, resistors, diode, whose values are determined with the TEG’s parameters. Note that such a TEG emulation is particularly suited when designing the electronic circuitry commonly associated to the TEG, to realize both Maximum Power Point Tracking and output voltage regulation. First, the proposed equivalent electrical circuits are validated through simulation with a SPICE environment in static operating conditions using only one value of either temperature gradient or heat flow. Then, they are also analyzed in dynamic operating conditions where both temperature gradient and heat flow are considered as time-varying functions.

  13. Modelling of Airship Flight Mechanics by the Projection Equivalent Method

    Directory of Open Access Journals (Sweden)

    Frantisek Jelenciak

    2015-12-01

    Full Text Available This article describes the projection equivalent method (PEM as a specific and relatively simple approach for the modelling of aircraft dynamics. By the PEM it is possible to obtain a mathematic al model of the aerodynamic forces and momentums acting on different kinds of aircraft during flight. For the PEM, it is a characteristic of it that -in principle - it provides an acceptable regression model of aerodynamic forces and momentums which exhibits reasonable and plausible behaviour from a dynamics viewpoint. The principle of this method is based on applying Newton's mechanics, which are then combined with a specific form of the finite element method to cover additional effects. The main advantage of the PEM is that it is not necessary to carry out measurements in a wind tunnel for the identification of the model's parameters. The plausible dynamical behaviour of the model can be achieved by specific correction parameters, which can be determined on the basis of experimental data obtained during the flight of the aircraft. In this article, we present the PEM as applied to an airship as well as a comparison of the data calculated by the PEM and experimental flight data.

  14. Individualised cancer therapeutics: dream or reality? Therapeutics construction.

    Science.gov (United States)

    Shen, Yuqiao; Senzer, Neil; Nemunaitis, John

    2005-11-01

    The analysis of DNA microarray and proteomic data, and the subsequent integration into functional expression sets, provides a circuit map of the hierarchical cellular networks responsible for sustaining the viability and environmental competitiveness of cancer cells, that is, their robust systematics. These technologies can be used to 'snapshot' the unique patterns of molecular derangements and modified interactions in cancer, and allow for strategic selection of therapeutics that best match the individual profile of the tumour. This review highlights technology that can be used to selectively disrupt critical molecular targets and describes possible vehicles to deliver the synthesised molecular therapeutics to the relevant cellular compartments of the malignant cells. RNA interference (RNAi) involves a group of evolutionarily conserved gene silencing mechanisms in which small sequences of double-stranded RNA or intrinsic antisense RNA trigger mRNA cleavage or translational repression, respectively. Although RNAi molecules can be synthesised to 'silence' virtually any gene, even if upregulated, a mechanism for selective delivery of RNAi effectors to sites of malignant disease remains challenging. The authors will discuss gene-modified conditionally replicating viruses as candidate vehicles for the delivery of RNAi.

  15. The impact of equivalence ratio oscillations on combustion dynamics in a backward-facing step combustor

    Energy Technology Data Exchange (ETDEWEB)

    Murat Altay, H.; Speth, Raymond L.; Hudgins, Duane E.; Ghoniem, Ahmed F. [Massachusetts Institute of Technology, Department of Mechanical Engineering, Cambridge, MA 02139 (United States)

    2009-11-15

    The combustion dynamics of propane-air flames are investigated in an atmospheric pressure, atmospheric inlet temperature, lean, premixed backward-facing step combustor. We modify the location of the fuel injector to examine the impact of equivalence ratio oscillations arriving at the flame on the combustion dynamics. Simultaneous pressure, velocity, heat-release rate and equivalence ratio measurements and high-speed video from the experiments are used to identify and characterize several distinct operating modes. When the fuel is injected far upstream from the step, the equivalence ratio arriving at the flame is steady and the combustion dynamics are controlled only by flame-vortex interactions. In this case, different dynamic regimes are observed depending on the operating parameters. When the fuel is injected close to the step, the equivalence ratio arriving at the flame exhibits oscillations. In the presence of equivalence ratio oscillations, the measured sound pressure level is significant across the entire range of lean mean equivalence ratios even if the equivalence ratio oscillations arriving at the flame are out-of-phase with the pressure oscillations. The combustion dynamics are governed primarily by the flame-vortex interactions, while the equivalence ratio oscillations have secondary effects. The equivalence ratio oscillations could generate variations in the combustion dynamics in each cycle under some operating conditions, destabilize the flame at the entire range of the lean equivalence ratios, and increase the value of the mean equivalence ratio at the lean blowout limit. (author)

  16. Enactments in Psychoanalysis: Therapeutic Benefits.

    Science.gov (United States)

    Stern, Stanley

    The therapeutic benefits of enactments are addressed. Relevant literature reveals disparate conceptions about the nature and use of enactments. Clarification of the term is discussed. This analyst's theoretical and technical evolution is addressed; it is inextricably related to using enactments. How can it not be? A taxonomy of enactments is presented. The article considers that enactments may be fundamental in the evolution from orthodox to contemporary analytic technique. Assumptions underlying enactments are explored, as are guidelines for using enactments. Finally, the article posits that enactments have widened the scope of analysis and contributed to its vitality.

  17. Imaging of prehospital stroke therapeutics

    Science.gov (United States)

    Lin, Michelle P; Sanossian, Nerses; Liebeskind, David S

    2016-01-01

    Despite significant quality improvement efforts to streamline in-hospital acute stroke care in the conventional model, there remain inherent layers of treatment delays, which could be eliminated with prehospital diagnostics and therapeutics administered in a mobile stroke unit. Early diagnosis using Telestroke and neuroimaging while in the ambulance may enable targeted routing to hospitals with specialized care, which will likely improve patient outcomes. Key clinical trials in Telestroke, mobile stroke units with prehospital neuroimaging capability, prehospital ultrasound and co-administration of various classes of neuroprotectives, antiplatelets and antithrombin agents with intravenous thrombolysis are discussed in this article. PMID:26308602

  18. Off-axis dose equivalent due to secondary neutrons from uniform scanning proton beams during proton radiotherapy.

    Science.gov (United States)

    Islam, M R; Collums, T L; Zheng, Y; Monson, J; Benton, E R

    2013-11-21

    The production of secondary neutrons is an undesirable byproduct of proton therapy and it is important to quantify the contribution from secondary neutrons to patient dose received outside the treatment volume. The purpose of this study is to investigate the off-axis dose equivalent from secondary neutrons experimentally using CR-39 plastic nuclear track detectors (PNTD) at ProCure Proton Therapy Center, Oklahoma City, OK. In this experiment, we placed several layers of CR-39 PNTD laterally outside the treatment volume inside a phantom and in air at various depths and angles with respect to the primary beam axis. Three different proton beams with max energies of 78, 162 and 226 MeV and 4 cm modulation width, a 5 cm diameter brass aperture, and a small snout located 38 cm from isocenter were used for the entire experiment. Monte Carlo simulations were also performed based on the experimental setup using a simplified snout configuration and the FLUKA Monte Carlo radiation transport code. The measured ratio of secondary neutron dose equivalent to therapeutic primary proton dose (H/D) ranged from 0.3 ± 0.08 mSv Gy−1 for 78 MeV proton beam to 37.4 ± 2.42 mSv Gy−1 for 226 MeV proton beam. Both experiment and simulation showed a similar decreasing trend in dose equivalent with distance to the central axis and the magnitude varied by a factor of about 2 in most locations. H/D was found to increase as the energy of the primary proton beam increased and higher H/D was observed at 135° compared to 45° and 90°. The overall higher H/D in air indicates the predominance of external neutrons produced in the nozzle rather than inside the body.

  19. Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

    Science.gov (United States)

    Black, Adrienne T; Hayden, Patrick J; Casillas, Robert P; Heck, Diane E; Gerecke, Donald R; Sinko, Patrick J; Laskin, Debra L; Laskin, Jeffrey D

    2010-12-01

    Sulfur mustard is a potent vesicant that induces inflammation, edema and blistering following dermal exposure. To assess molecular mechanisms mediating these responses, we analyzed the effects of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide, on EpiDerm-FT™, a commercially available full-thickness human skin equivalent. CEES (100-1000 μM) caused a concentration-dependent increase in pyknotic nuclei and vacuolization in basal keratinocytes; at high concentrations (300-1000 μM), CEES also disrupted keratin filament architecture in the stratum corneum. This was associated with time-dependent increases in expression of proliferating cell nuclear antigen, a marker of cell proliferation, and poly(ADP-ribose) polymerase (PARP) and phosphorylated histone H2AX, markers of DNA damage. Concentration- and time-dependent increases in mRNA and protein expression of eicosanoid biosynthetic enzymes including COX-2, 5-lipoxygenase, microsomal PGE₂ synthases, leukotriene (LT) A₄ hydrolase and LTC₄ synthase were observed in CEES-treated skin equivalents, as well as in antioxidant enzymes, glutathione S-transferases A1-2 (GSTA1-2), GSTA3 and GSTA4. These data demonstrate that CEES induces rapid cellular damage, cytotoxicity and inflammation in full-thickness skin equivalents. These effects are similar to human responses to vesicants in vivo and suggest that the full thickness skin equivalent is a useful in vitro model to characterize the biological effects of mustards and to develop potential therapeutics. Copyright © 2010 Elsevier Inc. All rights reserved.

  20. An Analytical Model of Leakage Neutron Equivalent Dose for Passively-Scattered Proton Radiotherapy and Validation with Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Christopher; Newhauser, Wayne, E-mail: newhauser@lsu.edu [Department of Physics and Astronomy, Louisiana State University and Agricultural and Mechanical College, 202 Nicholson Hall, Baton Rouge, LA 70803 (United States); Mary Bird Perkins Cancer Center, 4950 Essen Lane, Baton Rouge, LA 70809 (United States); Farah, Jad [Institut de Radioprotection et de Sûreté Nucléaire, Service de Dosimétrie Externe, BP-17, 92262 Fontenay-aux-Roses (France)

    2015-05-18

    Exposure to stray neutrons increases the risk of second cancer development after proton therapy. Previously reported analytical models of this exposure were difficult to configure and had not been investigated below 100 MeV proton energy. The purposes of this study were to test an analytical model of neutron equivalent dose per therapeutic absorbed dose (H/D) at 75 MeV and to improve the model by reducing the number of configuration parameters and making it continuous in proton energy from 100 to 250 MeV. To develop the analytical model, we used previously published H/D values in water from Monte Carlo simulations of a general-purpose beamline for proton energies from 100 to 250 MeV. We also configured and tested the model on in-air neutron equivalent doses measured for a 75 MeV ocular beamline. Predicted H/D values from the analytical model and Monte Carlo agreed well from 100 to 250 MeV (10% average difference). Predicted H/D values from the analytical model also agreed well with measurements at 75 MeV (15% average difference). The results indicate that analytical models can give fast, reliable calculations of neutron exposure after proton therapy. This ability is absent in treatment planning systems but vital to second cancer risk estimation.