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Sample records for tf tuning curves

  1. Computation of undulator tuning curves

    International Nuclear Information System (INIS)

    Dejus, Roger J.

    1997-01-01

    Computer codes for fast computation of on-axis brilliance tuning curves and flux tuning curves have been developed. They are valid for an ideal device (regular planar device or a helical device) using the Bessel function formalism. The effects of the particle beam emittance and the beam energy spread on the spectrum are taken into account. The applicability of the codes and the importance of magnetic field errors of real insertion devices are addressed. The validity of the codes has been experimentally verified at the APS and observed discrepancies are in agreement with predicted reduction of intensities due to magnetic field errors. The codes are distributed as part of the graphical user interface XOP (X-ray OPtics utilities), which simplifies execution and viewing of the results

  2. Maximally Informative Stimuli and Tuning Curves for Sigmoidal Rate-Coding Neurons and Populations

    Science.gov (United States)

    McDonnell, Mark D.; Stocks, Nigel G.

    2008-08-01

    A general method for deriving maximally informative sigmoidal tuning curves for neural systems with small normalized variability is presented. The optimal tuning curve is a nonlinear function of the cumulative distribution function of the stimulus and depends on the mean-variance relationship of the neural system. The derivation is based on a known relationship between Shannon’s mutual information and Fisher information, and the optimality of Jeffrey’s prior. It relies on the existence of closed-form solutions to the converse problem of optimizing the stimulus distribution for a given tuning curve. It is shown that maximum mutual information corresponds to constant Fisher information only if the stimulus is uniformly distributed. As an example, the case of sub-Poisson binomial firing statistics is analyzed in detail.

  3. The effect of the inner-hair-cell mediated transduction on the shape of neural tuning curves

    Science.gov (United States)

    Altoè, Alessandro; Pulkki, Ville; Verhulst, Sarah

    2018-05-01

    The inner hair cells of the mammalian cochlea transform the vibrations of their stereocilia into releases of neurotransmitter at the ribbon synapses, thereby controlling the activity of the afferent auditory fibers. The mechanical-to-neural transduction is a highly nonlinear process and it introduces differences between the frequency-tuning of the stereocilia and that of the afferent fibers. Using a computational model of the inner hair cell that is based on in vitro data, we estimated that smaller vibrations of the stereocilia are necessary to drive the afferent fibers above threshold at low (≤0.5 kHz) than at high (≥4 kHz) driving frequencies. In the base of the cochlea, the transduction process affects the low-frequency tails of neural tuning curves. In particular, it introduces differences between the frequency-tuning of the stereocilia and that of the auditory fibers resembling those between basilar membrane velocity and auditory fibers tuning curves in the chinchilla base. For units with a characteristic frequency between 1 and 4 kHz, the transduction process yields shallower neural than stereocilia tuning curves as the characteristic frequency decreases. This study proposes that transduction contributes to the progressive broadening of neural tuning curves from the base to the apex.

  4. On Usage of Pareto curves to Select Wind Turbine Controller Tunings to the Wind Turbulence Level

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh

    2015-01-01

    Model predictive control has in recently publications shown its potential for lowering of cost of energy of modern wind turbines. Pareto curves can be used to evaluate performance of these controllers with multiple conflicting objectives of power and fatigue loads. In this paper an approach...... to update an model predictive wind turbine controller tuning as the wind turbulence increases, as increased turbulence levels results in higher loads for the same controller tuning. In this paper the Pareto curves are computed using an industrial high fidelity aero-elastic model. Simulations show...

  5. Directional Tuning Curves, Elementary Movement Detectors, and the Estimation of the Direction of Visual Movement

    NARCIS (Netherlands)

    Hateren, J.H. van

    1990-01-01

    Both the insect brain and the vertebrate retina detect visual movement with neurons having broad, cosine-shaped directional tuning curves oriented in either of two perpendicular directions. This article shows that this arrangement can lead to isotropic estimates of the direction of movement: for any

  6. Lamb wave tuning curve calibration for surface-bonded piezoelectric transducers

    International Nuclear Information System (INIS)

    Sohn, Hoon; Lee, Sang Jun

    2010-01-01

    Surface-bonded lead zirconate titanate (PZT) transducers have been widely used for guided wave generation and measurement. For selective actuation and sensing of Lamb wave modes, the sizes of the transducers and the driving frequency of the input waveform should be tuned. For this purpose, a theoretical Lamb wave tuning curve (LWTC) of a specific transducer size is generally obtained. Here, the LWTC plots each Lamb wave mode' amplitude as a function of the driving frequency. However, a discrepancy between experimental and existing theoretical LWTCs has been observed due to little consideration of the bonding layer and the energy distribution between Lamb wave modes. In this study, calibration techniques for theoretical LWTCs are proposed. First, a theoretical LWTC is developed when circular PZT transducers are used for both Lamb wave excitation and sensing. Then, the LWTC is calibrated by estimating the effective PZT size with PZT admittance measurement. Finally, the energy distributions among symmetric and antisymmetric modes are taken into account for better prediction of the relative amplitudes between Lamb wave modes. The effectiveness of the proposed calibration techniques is examined through numerical simulations and experimental estimation of the LWTC using the circular PZT transducers instrumented on an aluminum plate

  7. Fabrication of new joints for SST-1 TF coil winding packs

    International Nuclear Information System (INIS)

    Prasad, Upendra; Sharma, A.N.; Patel, Dipak; Doshi, Kalpesh; Khristi, Yohan; Varmora, Pankaj; Chauhan, Pradeep; Jadeja, S.J.; Gupta, Pratibha; Pradhan, S.

    2013-01-01

    Highlights: • We have carried out work related with sub-nanoohm joints for superconducting Tokamak winding packs. • We have established fine tune QA/QC procedures for sub-nanoohm joints fabrication. • We have optimised welding parameters for cable in conduit conductors for fusion relevant magnets. • We have established precised measurement data acquisition system for low resistance measurements at cryogenic temperature. -- Abstract: The Toroidal Field (TF) magnet system of SST-1 has sixteen NbTi/Cu based coils with about one hundred Inter-Pancake (IP) and Inter-Coil (IC) joints. New box type helium leak tight, low DC resistance joints have been designed, fabricated and tested at 5 K temperature and 10 kA DC transport current. The prototype of this joint has been validated in laboratory as well as on spare TF coil winding pack. Moreover, the performance of these joints has been realised and validated on actual sixteen TF winding packs, the joint resistance of ∼0.5 nΩ repeatedly measured on hundreds of IP joints. The quality of terminations and joints was ensured at various stages of fabrication. The quality of joint box material was ensured by visual inspection, chemical analysis, radiography test, ultrasonic test, eddy current test, etc. This paper describes joint design drivers, joint design detail, prototype joint fabrication processes, quality assurance (QA)/quality control (QC) adopted during prototype and actual joint fabrication process, joint resistance measurement on actual TF coils and analysis of measured joint resistance in detail

  8. Comparing spatial tuning curves, spectral ripple resolution, and speech perception in cochlear implant users.

    Science.gov (United States)

    Anderson, Elizabeth S; Nelson, David A; Kreft, Heather; Nelson, Peggy B; Oxenham, Andrew J

    2011-07-01

    Spectral ripple discrimination thresholds were measured in 15 cochlear-implant users with broadband (350-5600 Hz) and octave-band noise stimuli. The results were compared with spatial tuning curve (STC) bandwidths previously obtained from the same subjects. Spatial tuning curve bandwidths did not correlate significantly with broadband spectral ripple discrimination thresholds but did correlate significantly with ripple discrimination thresholds when the rippled noise was confined to an octave-wide passband, centered on the STC's probe electrode frequency allocation. Ripple discrimination thresholds were also measured for octave-band stimuli in four contiguous octaves, with center frequencies from 500 Hz to 4000 Hz. Substantial variations in thresholds with center frequency were found in individuals, but no general trends of increasing or decreasing resolution from apex to base were observed in the pooled data. Neither ripple nor STC measures correlated consistently with speech measures in noise and quiet in the sample of subjects in this study. Overall, the results suggest that spectral ripple discrimination measures provide a reasonable measure of spectral resolution that correlates well with more direct, but more time-consuming, measures of spectral resolution, but that such measures do not always provide a clear and robust predictor of performance in speech perception tasks. © 2011 Acoustical Society of America

  9. Cue Reliability Represented in the Shape of Tuning Curves in the Owl's Sound Localization System.

    Science.gov (United States)

    Cazettes, Fanny; Fischer, Brian J; Peña, Jose L

    2016-02-17

    Optimal use of sensory information requires that the brain estimates the reliability of sensory cues, but the neural correlate of cue reliability relevant for behavior is not well defined. Here, we addressed this issue by examining how the reliability of spatial cue influences neuronal responses and behavior in the owl's auditory system. We show that the firing rate and spatial selectivity changed with cue reliability due to the mechanisms generating the tuning to the sound localization cue. We found that the correlated variability among neurons strongly depended on the shape of the tuning curves. Finally, we demonstrated that the change in the neurons' selectivity was necessary and sufficient for a network of stochastic neurons to predict behavior when sensory cues were corrupted with noise. This study demonstrates that the shape of tuning curves can stand alone as a coding dimension of environmental statistics. In natural environments, sensory cues are often corrupted by noise and are therefore unreliable. To make the best decisions, the brain must estimate the degree to which a cue can be trusted. The behaviorally relevant neural correlates of cue reliability are debated. In this study, we used the barn owl's sound localization system to address this question. We demonstrated that the mechanisms that account for spatial selectivity also explained how neural responses changed with degraded signals. This allowed for the neurons' selectivity to capture cue reliability, influencing the population readout commanding the owl's sound-orienting behavior. Copyright © 2016 the authors 0270-6474/16/362101-10$15.00/0.

  10. Fatigue assessment of the ITER TF coil case based on JJ1 fatigue tests

    International Nuclear Information System (INIS)

    Hamada, K.; Nakajima, H.; Takano, K.; Kudo, Y.; Tsutsumi, F.; Okuno, K.; Jong, C.

    2005-01-01

    The material of the TF coil case in the ITER requires to withstand cyclic electromagnetic forces applied up to 3 x 10 4 cycles at 4.2 K. A cryogenic stainless steel, JJ1, is used in high stress region of TF coil case. The fatigue characteristics (S-N curve) of JJ1 base metal and welded joint at 4.2 K has been measured. The fatigue strength of base metal and welded joint at 3 x 10 4 cycles are measured as 1032 and 848 MPa, respectively. The design S-N curve is derived from the measured data taking account of the safety factor of 20 for cycle-to-failure and 2 for fatigue strength, and it indicates that an equivalent alternating stress of the case should be kept less than 516 MPa for the base metal and 424 MPa for the welded joint at 3 x 10 4 cycles. It is demonstrated that the TF coil case has enough margins for the cyclic operation. It is also shown the welded joint should be located in low cyclic stress region because a residual stress affects the fatigue life

  11. Dynamic behavior of tuning fork shear-force structures in a SNOM system

    Energy Technology Data Exchange (ETDEWEB)

    Gao, Fengli [Department of Engineering Mechanics, AML, CNMM, Tsinghua University, Beijing 100084 (China); Li, Xide, E-mail: lixide@tsinghua.edu.cn [Department of Engineering Mechanics, AML, CNMM, Tsinghua University, Beijing 100084 (China); Wang, Jia [State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instruments, Tsinghua University, Beijing 100084 (China); Fu, Yu [Temasek Laboratories, Nanyang Technological University, 50 Nanyang Drive, 637553 (Singapore)

    2014-07-01

    Piezoelectric tuning fork shear-force structures are widely used as a distance control unit in a scanning near-field optical microscopy. However, the complex dynamic behavior among the micro-tuning forks (TFs), optical fiber probes, and the probe–surface interactions is still a crucial issue to achieve high-resolution imaging or near-field interaction inspections. Based on nonlinear beam tension-bending vibration theory, vibration equations in both longitudinal and lateral directions have been established when the TF structure and the optical fiber are treated as deformable structures. The relationship of the probe–surface interaction induced by Van der Waals force has been analyzed and the corresponding numerical results used to describe the vibrational behavior of the probe approaching the sample surface are obtained. Meanwhile, the viscous resistance of the liquid film on the sample surface has also been investigated using linear beam-bending vibration theory. Experiments testing the interaction between the probe and the water film on a single crystal silicon wafer have been carried out and the viscous resistance of the water film was estimated using the established equations. Finally, to use the TF-probe structure as a force sensor, the relation between the dynamic response of the TF-probe system and an external force on the probe tip was obtained. - Highlights: • Nonlinear vibration equation is established for a deformable tuning fork probe assembly. • Probe–sample interactions induced by Van der Waals force and viscous resistance are investigated. • The viscous resistance between the probe and the water film is estimated using testing results.

  12. Redesigning pH optimum of Geobacillus sp. TF16 endoxylanase through in silico designed DNA swapping strategy.

    Science.gov (United States)

    Uzuner, Ugur; Canakci, Sabriye; Bektas, Kadriye Inan; Sapmaz, Merve Tuncel; Belduz, Ali Osman

    2017-06-01

    Thermoalkaliphilic xylanases are highly desired and of great importance due to their vast potential in paper pulp and bleaching processes. Here, we report rapid, cost-effective, and result-oriented combinatorial potential of in silico DNA swapping strategy to engineer the pH optimum of industrially crucial enzymes, particularly engineering of Geobacillus sp. TF16 endoxylanase for alkaline environments. The 3D structures of Geobacillus sp. TF16 and donor Bacillus halodurans C-125 endoxylanases were firstly predicted, analyzed, and compared for their similarities before any in silico design of mutants. Reasonably, to improve its alkaline pH tolerance, the corresponding regions in Geobacillus sp.TF16 endoxylanase were further engineered by swapping with negatively-charged amino acid-rich regions from B. halodurans C-125 endoxylanase. Through only two of four in silico-designed mutants, the optimum pH of GeoTF16 endoxylanase was improved from 8.5 to 10.0. Moreover, as compared to GeoTF16 parental enzyme, both GeoInt3 and GeoInt4 mutants revealed (i) enhanced biobleaching performance, (ii) improved adaptability to alkaline conditions, and (iii) better activity for broader pH range. Unlike GeoTF16 losing activity at pH 11.0 completely, GeoInt4 retained 60% and 40% of its activity at pH 11.0 and 12.0, respectively. Thus, GeoInt4 stands out as a more competent biocatalyst that is suitable for alkaline environments of diverse industrial applications. The current study represents an efficient protein engineering strategy to adapt industrial catalysts to diverse processing conditions. Further comprehensive and fine-tuned research efforts may result in biotechnologically more promising outcomes. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  13. Identifying cochlear implant channels with poor electrode-neuron interface: partial tripolar, single-channel thresholds and psychophysical tuning curves.

    Science.gov (United States)

    Bierer, Julie Arenberg; Faulkner, Kathleen F

    2010-04-01

    The goal of this study was to evaluate the ability of a threshold measure, made with a restricted electrode configuration, to identify channels exhibiting relatively poor spatial selectivity. With a restricted electrode configuration, channel-to-channel variability in threshold may reflect variations in the interface between the electrodes and auditory neurons (i.e., nerve survival, electrode placement, and tissue impedance). These variations in the electrode-neuron interface should also be reflected in psychophysical tuning curve (PTC) measurements. Specifically, it is hypothesized that high single-channel thresholds obtained with the spatially focused partial tripolar (pTP) electrode configuration are predictive of wide or tip-shifted PTCs. Data were collected from five cochlear implant listeners implanted with the HiRes90k cochlear implant (Advanced Bionics Corp., Sylmar, CA). Single-channel thresholds and most comfortable listening levels were obtained for stimuli that varied in presumed electrical field size by using the pTP configuration for which a fraction of current (sigma) from a center-active electrode returns through two neighboring electrodes and the remainder through a distant indifferent electrode. Forward-masked PTCs were obtained for channels with the highest, lowest, and median tripolar (sigma = 1 or 0.9) thresholds. The probe channel and level were fixed and presented with either the monopolar (sigma = 0) or a more focused pTP (sigma > or = 0.55) configuration. The masker channel and level were varied, whereas the configuration was fixed to sigma = 0.5. A standard, three-interval, two-alternative forced choice procedure was used for thresholds and masked levels. Single-channel threshold and variability in threshold across channels systematically increased as the compensating current, sigma, increased and the presumed electrical field became more focused. Across subjects, channels with the highest single-channel thresholds, when measured with a

  14. Two-finger (TF) SPUDT cells.

    Science.gov (United States)

    Martin, Guenter; Biryukov, Sergey V; Schmidt, Hagen; Steiner, Bernd; Wall, Bert

    2011-03-01

    SPUDT cells including two fingers are only known thus far for so-called NSPUDT directions. In that case, usual solid-finger cells are used. The purpose of the present paper is to find SPUDT cell types consisting of two fingers only for pure mode directions. Two-finger (TF) cells for pure mode directions on substrates like 128°YX LiNbO(3) and YZ LiNbO(3) were found by means of an optimization procedure. The forward direction of a TF-cell SPUDT on 128°YX LiNbO(3) was determined experimentally. The properties of the new cells are compared with those of conventional SPUDT cells. The reflectivity of TF cells on 128°YX LiNbO(3) turns out to be two to three times larger than that of distributed acoustic reflection transducer (DART) and Hanma-Hunsinger cells at the same metal layer thickness.

  15. TfR Binding Peptide Screened by Phage Display Technology ...

    African Journals Online (AJOL)

    Purpose: To screen an hTfR affinity peptide and investigate its activity in vitro. Methods: hTfR ... Keywords: Peptide, hTfR, Transferrin receptor, Phage display technology, Enhanced green ..... mediated uptake of peptides that bind the human.

  16. Oracle SQL tuning with Oracle SQLTXPLAIN

    CERN Document Server

    Charalambides, Stelios

    2013-01-01

    Oracle SQL Tuning with SQLTXPLAIN is a practical guide to SQL tuning the way Oracle's own experts do it, using a freely downloadable tool called SQLTXPLAIN. Using this simple tool you'll learn how to tune even the most complex SQL, and you'll learn to do it quickly, without the huge learning curve usually associated with tuning as a whole.  Firmly based in real world problems, this book helps you reclaim system resources and avoid the most common bottleneck in overall performance, badly tuned SQL.  You'll learn how the optimizer works, how to take advantage of its latest features, and when it'

  17. [Laser Tuning Performance Testing and Optimization in TDLAS Oxygen Measuring Systems].

    Science.gov (United States)

    He, Jun-feng; Hu, Jun; Kan, Rui-feng; Xu, Zhen-yu; Wang, Tao

    2015-03-01

    TDLAS (tunable diode laser absorption spectroscopy) technology, with its unmatched advantages such as high selectivity molecular spectra, fast response, high sensitivity, non-contact measuring, become the preferred scheme for combustion process diagnosis, and can be effectively used for oxygen measuring. DFB (distributed feedback) laser diode with its small size, low power consumption, long service life, narrow linewidth, tunable wavelength has become the main choice of the TDLAS system. Performance of laser tuning characteristics is a key factor restricting TDLAS's measuring performance. According to TDLAS oxygen measuring system's working requirements, a simple experimental method was used to test and analyze tuning characteristics such as wavelength current, power current and wavelength temperature of a 764 nm DFB laser diode in the system. Nonlinear distortion of tuning curves was obvious, which affects oxygen measuring accuracy. The laser spectra's characteristics such as narrow linewidth, high side mode suppression ratio and wide wavelength tuning range are obvious, while its wavelength-current tuning curve with a tuning rate of about 0.023 nm x mA(-1) is not strictly linear. The higher the temperature the greater the threshold current, the PI curve is not strictly linear either. Temperature tuning curve is of good linearity, temperature-wave-length tuning rate keeps constant of about 0.056 nm/DEG C. Temperature tuning nonlinearity can be improved by high temperature control accuracy, and current power nonlinearity can be improved by setting the reference light path. In order to solve the wavelength current tuning nonlinear problems, the method of DA controlling injection current was considered to compensate for non-linear wavelength current tuning according to DFB laser diode tuning mechanism and polynomial fitting of test results. In view of different type of lasers, this method needs only one polynomial fitting process before the system's initial work. The

  18. Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index.

    Science.gov (United States)

    Skikne, Barry S; Punnonen, Kari; Caldron, Paul H; Bennett, Michael T; Rehu, Mari; Gasior, Gail H; Chamberlin, Janna S; Sullivan, Linda A; Bray, Kurtis R; Southwick, Paula C

    2011-11-01

    Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the most prevalent forms of anemia and often occur concurrently. Standard tests of iron status used in differential diagnosis are affected by inflammation, hindering clinical interpretation. In contrast, soluble transferrin receptor (sTfR) indicates iron deficiency and is unaffected by inflammation. Objectives of this prospective multicenter clinical trial were to evaluate and compare the diagnostic accuracy of sTfR and the sTfR/log ferritin index (sTfR Index) for differential diagnosis using the automated Access(®) sTfR assay (Beckman Coulter) and sTfR Index. We consecutively enrolled 145 anemic patients with common disorders associated with IDA and ACD. Subjects with IDA or ACD + IDA had significantly higher sTfR and sTfR Index values than subjects with ACD (P < 0.0001). ROC curves produced the following cutoffs for sTfR: 21 nmol/L (or 1.55 mg/L), and the sTfR Index: 14 (using nmol/L) (or 1.03 using mg/L). The sTfR Index was superior to sTfR (AUC 0.87 vs. 0.74, P < 0.0001). Use of all three parameters in combination more than doubled the detection of IDA, from 41% (ferritin alone) to 92% (ferritin, sTfR, sTfR Index). Use of sTfR and the sTfR Index improves detection of IDA, particularly in situations where routine markers provide equivocal results. Findings demonstrate a significant advantage in the simultaneous determination of ferritin, sTfR and sTfR Index. Obtaining a ferritin level alone may delay diagnosis of combined IDA and ACD. Copyright © 2011 Wiley-Liss, Inc.

  19. Thermo hydraulic and quench propagation characteristics of SST-1 TF coil

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, A.N., E-mail: ansharma@ipr.res.in [Institute for Plasma Research, Gandhinagar (India); Pradhan, S. [Institute for Plasma Research, Gandhinagar (India); Duchateau, J.L. [CEA Cadarache, 13108 St Paul lez Durance Cedex (France); Khristi, Y.; Prasad, U.; Doshi, K.; Varmora, P.; Patel, D.; Tanna, V.L. [Institute for Plasma Research, Gandhinagar (India)

    2014-02-15

    Highlights: • Details of SST-1 TF coils, CICC. • Details of SST-1 TF coil cold test. • Quench analysis of TF magnet. • Flow changes following quench. • Predictive analysis of assembled magnet system. - Abstract: SST-1 toroidal field (TF) magnet system is comprising of sixteen superconducting modified ‘D’ shaped TF coils. During single coil test campaigns spanning from June 10, 2010 till January 24, 2011; the electromagnetic, thermal hydraulic and mechanical performances of each TF magnet have been qualified at its respective nominal operating current of 10,000 A in either two-phase or supercritical helium cooling conditions. During the current charging experiments, few quenches have initiated either as a consequence of irrecoverable normal zones or being induced in some of the TF magnets. Quench evolution in the TF coils have been analyzed in detail in order to understand the thermal hydraulic and quench propagation characteristics of the SST-1 TF magnets. The same were also simulated using 1D code Gandalf. This paper elaborates the details of the analyses and the quench simulation results. A predictive quench propagation analysis of 16 assembled TF magnets system has also been reported in this paper.

  20. Operation of SST-1 TF power supply during SST-1 campaigns

    International Nuclear Information System (INIS)

    Sharma, Dinesh Kumar; Vora, Murtuza M.; Ojha, Amit; Singh, Akhilesh Kumar; Bhavsar, Chirag

    2015-01-01

    Highlights: • SST-1 TF power supply is 12 pulse SCR converter circuit. • TF power supply protection, measurement and control scheme are explained. • Quench, emergency and normal shot process is explained and results of SST-1 campaigns are shown. • Dynamic control of TF current. • The paper shows the results of last ten SST-1 campaigns. - Abstract: SST-1 TF power supply provides the direct current for the required magnetic field of TF coil. TF power supply includes transformer, 12-pulse converter, bus bar, water-cooled cable, protection and measuring equipments, and isolator, VME DAC system and GUI software. TF power supply is operated through GUI software built in TCL/Tk. VME DAC system monitors the parameters, provides On/Off commands, voltage and current references and initiates predefined reference to emergency shutdown. The emergency shutdown is hardwired to TF power supply from central control. During quench power supply converter opens DCCB and dump resistor is connected in the circuit and VME DAC system acquires bus bar voltage, dump voltage and dump current. Operation of TF power supply also requires monitoring of SCR and transformer temperature and water flow rate of water-cooled cable during high current long pulse shot. Before start up of TF power supply a quench simulation is performed to check the readiness of protection. This paper describes pre startup operation, normal shot operation, emergency and quench process, dynamic control and complete shutdown operation of TF power supply.

  1. Operation of SST-1 TF power supply during SST-1 campaigns

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Dinesh Kumar, E-mail: dinesh@ipr.res.in; Vora, Murtuza M.; Ojha, Amit; Singh, Akhilesh Kumar; Bhavsar, Chirag

    2015-10-15

    Highlights: • SST-1 TF power supply is 12 pulse SCR converter circuit. • TF power supply protection, measurement and control scheme are explained. • Quench, emergency and normal shot process is explained and results of SST-1 campaigns are shown. • Dynamic control of TF current. • The paper shows the results of last ten SST-1 campaigns. - Abstract: SST-1 TF power supply provides the direct current for the required magnetic field of TF coil. TF power supply includes transformer, 12-pulse converter, bus bar, water-cooled cable, protection and measuring equipments, and isolator, VME DAC system and GUI software. TF power supply is operated through GUI software built in TCL/Tk. VME DAC system monitors the parameters, provides On/Off commands, voltage and current references and initiates predefined reference to emergency shutdown. The emergency shutdown is hardwired to TF power supply from central control. During quench power supply converter opens DCCB and dump resistor is connected in the circuit and VME DAC system acquires bus bar voltage, dump voltage and dump current. Operation of TF power supply also requires monitoring of SCR and transformer temperature and water flow rate of water-cooled cable during high current long pulse shot. Before start up of TF power supply a quench simulation is performed to check the readiness of protection. This paper describes pre startup operation, normal shot operation, emergency and quench process, dynamic control and complete shutdown operation of TF power supply.

  2. Extending TF1: Argument parsing, function composition, and vectorization

    CERN Document Server

    Tsang Mang Kin, Arthur Leonard

    2017-01-01

    In this project, we extend the functionality of the TF1 function class in root. We add argument parsing, making it possible to freely pass variables and parameters into pre-defined and user-defined functions. We also introduce a syntax to use certain compositions of functions, namely normalized sums and convolutions, directly in TF1. Finally, we introduce some simple vectorization functionality to TF1 and demonstrate the potential to speed up parallelizable computations.

  3. Clustering of malaria treatment failure (TF) in Daraweesh: hints for host genetic susceptibility to TF with emphasis on immune-modulating SNPs

    DEFF Research Database (Denmark)

    Giha, Hayder A; ElGhazali, Gehad; Nasr, Amre

    2010-01-01

    In malaria, drug resistance and treatment failure (TF) are not synonymous, although are escalating together. Over 9 years of surveillances for malaria morbidity and TF in Daraweesh village in eastern Sudan (1991-2004), 136 donors (15-78 years) from 43 households, treated for 278 malaria episodes ...

  4. Quench characterization and thermo hydraulic analysis of SST-1 TF magnet busbar

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, A.N., E-mail: ansharma@ipr.res.in [Institute for Plasma Research, Gandhinagar (India); Pradhan, S. [Institute for Plasma Research, Gandhinagar (India); Duchateau, J.L. [CEA Cadarache, 13108 St Paul lez Durance Cedex (France); Khristi, Y.; Prasad, U.; Doshi, K.; Varmora, P.; Tanna, V.L.; Patel, D.; Panchal, A. [Institute for Plasma Research, Gandhinagar (India)

    2015-01-15

    Highlights: • Details of SST-1 TF busbar quench detection. • Simulation of slow propagating normal zone. • Thermo hydraulic analyses of TF busbar in current feeder system. - Abstract: Toroidal field (TF) magnet system of steady-state superconducting tokamak-1 (SST-1) has 16 superconducting coils. TF coils are cooled with forced flow supercritical helium at 0.4 MPa, at 4.5 K and operate at nominal current of 10,000 A. Prior to TF magnet system assembly in SST-1 tokamak, each TF coil was tested individually in a test cryostat. During these tests, TF coil was connected to a pair of conventional helium vapor cooled current leads. The connecting busbar was made from the same base cable-in-conduit-conductor (CICC) of SST-1 superconducting magnet system. Quenches experimentally observed in the busbar sections of the single coil test setups have been analyzed in this paper. A steady state thermo hydraulic analysis of TF magnet busbar in actual SST-1 tokamak assembly has been done. The experimental observations of quench and results of relevant thermo hydraulic analyses have been used to predict the safe operation regime of TF magnet system busbar during actual SST-1 tokamak operational scenarios.

  5. Shaping ability of several nickel–titanium systems in double-curved simulated canals

    Directory of Open Access Journals (Sweden)

    Mothanna Alrahabi

    2017-06-01

    Conclusion: The iRaCe, ProTaper Next, Wave One, and TF systems preserved the original shape of the double-curved (S-shaped canal with minimum root canal transportation. These systems produced satisfactory root canal instrumentation in S-shaped canals.

  6. Status of GENIUS-TF-II and TF-III-The long-term stability of naked detectors in liquid nitrogen

    Energy Technology Data Exchange (ETDEWEB)

    Klapdor-Kleingrothaus, H.V. [Max-Planck-Institut fuer Kernphysik, P.O. Box 10 39 80, D-69029 Heidelberg (Germany)]. E-mail: H.Klapdor@mpi-hd.mpg.de; Krivosheina, I.V. [Max-Planck-Institut fuer Kernphysik, P.O. Box 10 39 80, D-69029 Heidelberg (Germany)

    2006-10-15

    GENIUS-TF-II is a setup of six naked high purity Ge detectors (15kg) in liquid nitrogen in Gran Sasso. It has been installed in October, 2004-after the first four naked Ge detectors had been installed on May 5, 2003 (GENIUS-TF-I). The GENIUS-Test-Facility (GENIUS-TF) is the first and up to now only setup ever testing the novel technique aiming at extreme background reduction in search for rare decays in particular underground. The goal of GENIUS-TF was to test some key operational parameters of the full GENIUS project proposal in 1997 [H.V. Klapdor-Kleingrothaus, Int. J. Mod. Phys. A 13 (1998) 3953; H.V. Klapdor-Kleingrothaus, J. Hellmig, M. Hirsch, GENIUS-Proposal, 20 November 1997; J. Hellmig and H.V. Klapdor-Kleingrothaus, Z. Phys. A 359 ( 1997) 351 and nucl-ex/9801004; H.V. Klapdor-Kleingrothaus, M. Hirsch, Z. Phys. A 359 (1997) 361; H.V. Klapdor-Kleingrothaus, J. Hellmig, M. Hirsch, J. Phys. G 24 (1998) 483; H.V. Klapdor-Kleingrothaus, CERN Courier, November 1997, pp. 16-18]. Simultaneous physical goal is to search for the annual modulation of the Dark Matter signal [H.V. Klapdor-Kleingrothaus, et al., Nucl. Instr. and Meth. A 481 (2002) 149; C. Tomei, A. Dietz, I. Krivosheina, H.V. Klapdor-Kleingrothaus, Nucl. Instr. and Meth. 508 (2003) 343]. After operation of GENIUS-TF over three years with finally six naked Ge detectors (15kg) in liquid nitrogen in Gran Sasso we realize serious problems for realization of a full-size GENIUS-like experiment: (1) Background from Rn222 diffusing into the setup, on a level far beyond the expectation. (2) Limited long-term stability of naked detectors in liquid nitrogen as result of increasing leakage current. None of the six detectors is running after three years with the nominal leakage current. Three of the six detectors do not work any more at all. The results of our three years of investigation of the long-term stability may cast doubt on the possibility to perform full GENIUS-like projects.

  7. Status of GENIUS-TF-II and TF-III-The long-term stability of naked detectors in liquid nitrogen

    International Nuclear Information System (INIS)

    Klapdor-Kleingrothaus, H.V.; Krivosheina, I.V.

    2006-01-01

    GENIUS-TF-II is a setup of six naked high purity Ge detectors (15kg) in liquid nitrogen in Gran Sasso. It has been installed in October, 2004-after the first four naked Ge detectors had been installed on May 5, 2003 (GENIUS-TF-I). The GENIUS-Test-Facility (GENIUS-TF) is the first and up to now only setup ever testing the novel technique aiming at extreme background reduction in search for rare decays in particular underground. The goal of GENIUS-TF was to test some key operational parameters of the full GENIUS project proposal in 1997 [H.V. Klapdor-Kleingrothaus, Int. J. Mod. Phys. A 13 (1998) 3953; H.V. Klapdor-Kleingrothaus, J. Hellmig, M. Hirsch, GENIUS-Proposal, 20 November 1997; J. Hellmig and H.V. Klapdor-Kleingrothaus, Z. Phys. A 359 ( 1997) 351 and nucl-ex/9801004; H.V. Klapdor-Kleingrothaus, M. Hirsch, Z. Phys. A 359 (1997) 361; H.V. Klapdor-Kleingrothaus, J. Hellmig, M. Hirsch, J. Phys. G 24 (1998) 483; H.V. Klapdor-Kleingrothaus, CERN Courier, November 1997, pp. 16-18]. Simultaneous physical goal is to search for the annual modulation of the Dark Matter signal [H.V. Klapdor-Kleingrothaus, et al., Nucl. Instr. and Meth. A 481 (2002) 149; C. Tomei, A. Dietz, I. Krivosheina, H.V. Klapdor-Kleingrothaus, Nucl. Instr. and Meth. 508 (2003) 343]. After operation of GENIUS-TF over three years with finally six naked Ge detectors (15kg) in liquid nitrogen in Gran Sasso we realize serious problems for realization of a full-size GENIUS-like experiment: (1) Background from Rn222 diffusing into the setup, on a level far beyond the expectation. (2) Limited long-term stability of naked detectors in liquid nitrogen as result of increasing leakage current. None of the six detectors is running after three years with the nominal leakage current. Three of the six detectors do not work any more at all. The results of our three years of investigation of the long-term stability may cast doubt on the possibility to perform full GENIUS-like projects

  8. Broader visual orientation tuning in patients with schizophrenia

    Directory of Open Access Journals (Sweden)

    Ariel eRokem

    2011-11-01

    Full Text Available Reduced gamma-aminobutyric acid (GABA levels in cerebral cortex are thought to contribute to information processing deficits in patients with schizophrenia (SZ, and we have previously reported lower in vivo GABA levels in the visual cortex of patients with SZ. GABA-mediated inhibition plays a role in sharpening orientation tuning of visual cortical neurons. Therefore, we predicted that tuning for visual stimulus orientation would be wider in SZ. We measured orientation tuning with a psychophysical procedure in which subjects performed a target detection task of a low-contrast oriented grating, following adaptation to a high-contrast grating. Contrast detection thresholds were determined for a range of adapter-target orientation offsets. For both SZ and healthy controls, contrast thresholds decreased as orientation offset increased, suggesting that this tuning curve reflects the selectivity of visual cortical neurons for stimulus orientation. After accounting for generalized deficits in task performance in SZ, there was no difference between patients and controls for detection of target stimuli having either the same orientation as the adapter or orientations far from the adapter. However, patients’ thresholds were significantly higher for intermediate adapter-target offsets. In addition, the mean width parameter of a Gaussian fit to the psychophysical orientation tuning curves was significantly larger for the patient group. We also present preliminary data relating visual cortical GABA levels, as measured with magnetic resonance spectroscopy, and orientation tuning width. These results suggest that our finding of broader orientation tuning in SZ may be due to diminished visual cortical GABA levels.

  9. In-Session Caregiver Behavior Predicts Symptom Change in Youth Receiving Trauma-Focused Cognitive Behavioral Therapy (TF-CBT)

    Science.gov (United States)

    Yasinski, Carly; Hayes, Adele; Ready, C. Beth; Cummings, Jorden A.; Berman, Ilana S.; McCauley, Thomas; Webb, Charles; Deblinger, Esther

    2016-01-01

    Objective Involving caregivers in trauma-focused treatments for youth has been shown to result in better outcomes, but it is not clear which in-session caregiver behaviors enhance or inhibit this effect. The current study examined the associations between caregiver behaviors during Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) and youth cognitive processes and symptoms. Method Participants were a racially diverse sample of Medicaid-eligible youth (ages 7–17) and their non-offending caregivers (N= 71 pairs) who received TF-CBT through an effectiveness study in a community setting. Caregiver and youth processes were coded from audio-recorded sessions, and outcomes were measured using the Child Behavior Checklist (CBCL) and UCLA PTSD Reaction Index for DSM-IV (UPID) at 3, 6, 9, and 12 months post-intake. Results Piecewise linear growth curve modeling revealed that during the trauma narrative phase of TF-CBT, caregivers’ cognitive-emotional processing of their own and their child's trauma-related reactions predicted decreases in youth internalizing and externalizing symptoms over treatment. Caregiver support predicted lower internalizing symptoms over follow-up. In contrast, caregiver avoidance and blame of the child predicted worsening of youth internalizing and externalizing symptoms over follow-up. Caregiver avoidance early in treatment also predicted worsening of externalizing symptoms over follow-up. During the narrative phase, caregiver blame and avoidance were correlated with more child overgeneralization of trauma beliefs, and blame was also associated with less child accommodation of balanced beliefs. Conclusions The association between in-session caregiver behaviors and youth symptomatology during and after TF-CBT highlights the importance of assessing and targeting these behaviors to improve clinical outcomes. PMID:27618641

  10. Structural analysis of TFTR TF coils and support structure for 6 Tesla operation

    International Nuclear Information System (INIS)

    Zatz, I.J.; Cargulia, G.; Lontai, L.

    1995-01-01

    The Tokamak Fusion Test Reactor (TFTR), which has been on line since December 1982, has successfully operated at its design Toroidal Field (TF) of 5.2 Tesla. Analysis of test data has indicated that the measured peak D-D neutron power in supershots may be scaled to the fourth power of TF field. Increasing the TF field to 6 Tesla provides the opportunity to explore the possibility of improving the D-T fusion yield, with the use of tritium. This increase in TF field from 5.2 to 6.0 Tesla increases the centering force by 33% and the out-of-plane force by 15% over previous peak operating levels. To examine the impact of the increase in loads on the TF coil, case and supporting structure, finite element analyses (FEA) were performed with and without the presence of loose bolts in the TF case. Note that the loose bolts comprise a fraction of the total number of bolts fastening the TF case sidewalls to the inner and outer rings of the case. Extensive analysis was performed using the FEA results in conjunction with supplementary calculations. Results are presented for the TF case, bolts, copper conductors, insulation, and supporting structure which indicate that the TF coils can successfully operate at 6 Tesla for a reasonable number of pulses

  11. SU-E-T-488: An Iso-Dose Curve Based Interactive IMRT Optimization System for Physician-Driven Plan Tuning

    International Nuclear Information System (INIS)

    Shi, F; Tian, Z; Jia, X; Jiang, S; Zarepisheh, M; Cervino, L

    2014-01-01

    Purpose: In treatment plan optimization for Intensity Modulated Radiation Therapy (IMRT), after a plan is initially developed by a dosimetrist, the attending physician evaluates its quality and often would like to improve it. As opposed to having the dosimetrist implement the improvements, it is desirable to have the physician directly and efficiently modify the plan for a more streamlined and effective workflow. In this project, we developed an interactive optimization system for physicians to conveniently and efficiently fine-tune iso-dose curves. Methods: An interactive interface is developed under C++/Qt. The physician first examines iso-dose lines. S/he then picks an iso-dose curve to be improved and drags it to a more desired configuration using a computer mouse or touchpad. Once the mouse is released, a voxel-based optimization engine is launched. The weighting factors corresponding to voxels between the iso-dose lines before and after the dragging are modified. The underlying algorithm then takes these factors as input to re-optimize the plan in near real-time on a GPU platform, yielding a new plan best matching the physician's desire. The re-optimized DVHs and iso-dose curves are then updated for the next iteration of modifications. This process is repeated until a physician satisfactory plan is achieved. Results: We have tested this system for a series of IMRT plans. Results indicate that our system provides the physicians an intuitive and efficient tool to edit the iso-dose curves according to their preference. The input information is used to guide plan re-optimization, which is achieved in near real-time using our GPU-based optimization engine. Typically, a satisfactory plan can be developed by a physician in a few minutes using this tool. Conclusion: With our system, physicians are able to manipulate iso-dose curves according to their preferences. Preliminary results demonstrate the feasibility and effectiveness of this tool

  12. A-10/TF34 Turbine Engine Monitoring System (TEMS)

    Science.gov (United States)

    Christopher, R. G.

    1981-01-01

    The hardware and software development of the A-10/TF34 turbine engine monitoring system (TEMS) is described. The operation and interfaces of the A-10/TF34 TEMS hardware are discussed with particular emphasis on function, capabilities, and limitations. The TEMS data types are defined and the various data acquisition modes are explained. Potential data products are also discussed.

  13. Transient Abnormalities in Masking Tuning Curve in Early Progressive Hearing Loss Mouse Model

    Directory of Open Access Journals (Sweden)

    Marion Souchal

    2018-01-01

    Full Text Available Damage to cochlear outer hair cells (OHCs usually affects frequency selectivity in proportion to hearing threshold increase. However, the current clinical heuristics that attributes poor hearing performance despite near-normal auditory sensitivity to auditory neuropathy or “hidden” synaptopathy overlooks possible underlying OHC impairment. Here, we document the part played by OHCs in influencing suprathreshold auditory performance in the presence of noise in a mouse model of progressive hair cell degeneration, the CD1 strain, at postnatal day 18–30 stages when high-frequency auditory thresholds remained near-normal. Nonetheless, total loss of high-frequency distortion product otoacoustic emissions pointed to nonfunctioning basal OHCs. This “discordant profile” came with a huge low-frequency shift of masking tuning curves that plot the level of interfering sound necessary to mask the response to a probe tone, against interfering frequency. Histology revealed intense OHC hair bundle abnormalities in the basal cochlea uncharacteristically associated with OHC survival and preserved coupling with the tectorial membrane. This pattern dismisses the superficial diagnosis of “hidden” neuropathy while underpinning a disorganization of cochlear frequency mapping with optimistic high-frequency auditory thresholds perhaps because responses to high frequencies are apically shifted. The audiometric advantage of frequency transposition is offset by enhanced masking by low-frequency sounds, a finding essential for guiding rehabilitation.

  14. In-session caregiver behavior predicts symptom change in youth receiving trauma-focused cognitive behavioral therapy (TF-CBT).

    Science.gov (United States)

    Yasinski, Carly; Hayes, Adele M; Ready, C Beth; Cummings, Jorden A; Berman, Ilana S; McCauley, Thomas; Webb, Charles; Deblinger, Esther

    2016-12-01

    Involving caregivers in trauma-focused treatments for youth has been shown to result in better outcomes, but it is not clear which in-session caregiver behaviors enhance or inhibit this effect. The current study examined the associations between caregiver behaviors during Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) and youth cognitive processes and symptoms. Participants were a racially diverse sample of Medicaid-eligible youth (ages 7-17) and their nonoffending caregivers (N = 71 pairs) who received TF-CBT through an effectiveness study in a community setting. Caregiver and youth processes were coded from audio-recorded sessions, and outcomes were measured using the Child Behavior Checklist (CBCL) and UCLA PTSD Reaction Index for Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition (DSM-IV; UPID) at 3, 6, 9, and 12 months postintake. Piecewise linear growth curve modeling revealed that during the trauma narrative phase of TF-CBT, caregivers' cognitive-emotional processing of their own and their child's trauma-related reactions predicted decreases in youth internalizing and externalizing symptoms over treatment. Caregiver support predicted lower internalizing symptoms over follow-up. In contrast, caregiver avoidance and blame of the child predicted worsening of youth internalizing and externalizing symptoms over follow-up. Caregiver avoidance early in treatment also predicted worsening of externalizing symptoms over follow-up. During the narrative phase, caregiver blame and avoidance were correlated with more child overgeneralization of trauma beliefs, and blame was also associated with less child accommodation of balanced beliefs. The association between in-session caregiver behaviors and youth symptomatology during and after TF-CBT highlights the importance of assessing and targeting these behaviors to improve clinical outcomes. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  15. Selective enhancement of orientation tuning before saccades.

    Science.gov (United States)

    Ohl, Sven; Kuper, Clara; Rolfs, Martin

    2017-11-01

    Saccadic eye movements cause a rapid sweep of the visual image across the retina and bring the saccade's target into high-acuity foveal vision. Even before saccade onset, visual processing is selectively prioritized at the saccade target. To determine how this presaccadic attention shift exerts its influence on visual selection, we compare the dynamics of perceptual tuning curves before movement onset at the saccade target and in the opposite hemifield. Participants monitored a 30-Hz sequence of randomly oriented gratings for a target orientation. Combining a reverse correlation technique previously used to study orientation tuning in neurons and general additive mixed modeling, we found that perceptual reports were tuned to the target orientation. The gain of orientation tuning increased markedly within the last 100 ms before saccade onset. In addition, we observed finer orientation tuning right before saccade onset. This increase in gain and tuning occurred at the saccade target location and was not observed at the incongruent location in the opposite hemifield. The present findings suggest, therefore, that presaccadic attention exerts its influence on vision in a spatially and feature-selective manner, enhancing performance and sharpening feature tuning at the future gaze location before the eyes start moving.

  16. Palmitoylation of Sindbis Virus TF Protein Regulates Its Plasma Membrane Localization and Subsequent Incorporation into Virions.

    Science.gov (United States)

    Ramsey, Jolene; Renzi, Emily C; Arnold, Randy J; Trinidad, Jonathan C; Mukhopadhyay, Suchetana

    2017-02-01

    Palmitoylation is a reversible, posttranslational modification that helps target proteins to cellular membranes. The alphavirus small membrane proteins 6K and TF have been reported to be palmitoylated and to positively regulate budding. 6K and TF are isoforms that are identical in their N termini but unique in their C termini due to a -1 ribosomal frameshift during translation. In this study, we used cysteine (Cys) mutants to test differential palmitoylation of the Sindbis virus 6K and TF proteins. We modularly mutated the five Cys residues in the identical N termini of 6K and TF, the four additional Cys residues in TF's unique C terminus, or all nine Cys residues in TF. Using these mutants, we determined that TF palmitoylation occurs primarily in the N terminus. In contrast, 6K is not palmitoylated, even on these shared residues. In the C-terminal Cys mutant, TF protein levels increase both in the cell and in the released virion compared to the wild type. In viruses with the N-terminal Cys residues mutated, TF is much less efficiently localized to the plasma membrane, and it is not incorporated into the virion. The three Cys mutants have minor defects in cell culture growth but a high incidence of abnormal particle morphologies compared to the wild-type virus as determined by transmission electron microscopy. We propose a model where the C terminus of TF modulates the palmitoylation of TF at the N terminus, and palmitoylated TF is preferentially trafficked to the plasma membrane for virus budding. Alphaviruses are a reemerging viral cause of arthritogenic disease. Recently, the small 6K and TF proteins of alphaviruses were shown to contribute to virulence in vivo Nevertheless, a clear understanding of the molecular mechanisms by which either protein acts to promote virus infection is missing. The TF protein is a component of budded virions, and optimal levels of TF correlate positively with wild-type-like particle morphology. In this study, we show that the

  17. Special remote tooling developed and utilized to tighten TFTR TF coil casing bolts

    International Nuclear Information System (INIS)

    Burgess, T.W.; Walton, G.R.; Meighan, T.G.; Paul, B.L.

    1993-01-01

    Special tooling has been developed and used to tighten toroidal field (TF) coil casing bolts that have loosened from years of Tokamak Fusion Test Reactor (TFTR) operation. Due to their location, many of the TF casing bolts cannot be directly accessed or viewed; their condition was first discovered during unrelated inspections in 1988. Engineering solutions were, sought until 1992, when a remotely operated wrench concept was successfully demonstrated on a TF coil mockup. The concept was developed into several working tools that have successfully been applied to tighten several thousand TF casing bolts during recent scheduled outages. This effort has improved the integrity and reliability of the TF coil system in preparing for the final experimental phase of the TFTR. This paper discusses the design and application of this tooling

  18. The solar kettle-thermos flask (SK-TF) and solar vacuum tube oven

    Energy Technology Data Exchange (ETDEWEB)

    Yak, Alex Kee Koo [AkayConsult Enterprise, Johor Bahru (Malaysia)

    2008-07-01

    The Solar Kettle-Thermos Flask (SK-TF) and Solar Vacuum Tube Oven (SaVeTao): A Cost Effective, Sustainable and Renewable Water Pasteurization and Food Processing System For The Developing World. Based on the perfect solar thermal energy harvesting paradigm of maximum solar radiation absorption and minimum loss of stored converted solar thermal energy, Solar Vacuum Glass Tubes (SVGT) indefinitely delivers solar pasteurized safe drinking water, powered solely by free solar energy. The SVGT is the heart of the SK-TF. Being vacuum insulated, the SK-TF doubles up as a vacuum flask, delivering stored solar heated water in the morning before the Sun is up. With a high stagnation temperature of more than 200 C, the SK-TF can also be used for other heating purposes e.g. an oven or autoclave. Powered solely by free solar energy, the SK-TF and SaVeTaO could very well be the answer in providing safe solar pasteurized drinking water and cooking to the global poor and needy in a sustainable and renewable way. (orig.)

  19. The emerging role of neutrophils in thrombosis – The journey of TF through NETs

    Directory of Open Access Journals (Sweden)

    Konstantinos eKambas

    2012-12-01

    Full Text Available The production of TF by neutrophils and their contribution in thrombosis was until recently a matter of scientific debate. Experimental data suggested the de novo TF production by neutrophils under inflammatory stimuli, while others proposed that these cells acquired microparticle-derived TF. Recent experimental evidence revealed the critical role of neutrophils in thrombotic events. Neutrophil derived TF has been implicated in this process in several human and animal models. Additionally, neutrophil extracellular trap (NET release has emerged as a major contributor in neutrophil-driven thrombogenicity in disease models including sepsis, deep venous thrombosis and malignancy. It is suggested that NETs provide the scaffold for fibrin deposition and platelet entrapment and subsequent activation. The recently reported autophagy-dependent extracellular delivery of TF in NETs further supports the involvement of neutrophils in thrombosis. Herein, we seek to review novel data regarding the role of neutrophils in thrombosis, emphasizing the implication of TF and NETs.

  20. Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

    Science.gov (United States)

    Couch, Jessica A; Yu, Y Joy; Zhang, Yin; Tarrant, Jacqueline M; Fuji, Reina N; Meilandt, William J; Solanoy, Hilda; Tong, Raymond K; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Gadkar, Kapil; Prabhu, Saileta; Ordonia, Benjamin A; Nguyen, Quyen; Lin, Yuwen; Lin, Zhonghua; Balazs, Mercedesz; Scearce-Levie, Kimberly; Ernst, James A; Dennis, Mark S; Watts, Ryan J

    2013-05-01

    Bispecific antibodies using the transferrin receptor (TfR) have shown promise for boosting antibody uptake in brain. Nevertheless, there are limited data on the therapeutic properties including safety liabilities that will enable successful development of TfR-based therapeutics. We evaluate TfR/BACE1 bispecific antibody variants in mouse and show that reducing TfR binding affinity improves not only brain uptake but also peripheral exposure and the safety profile of these antibodies. We identify and seek to address liabilities of targeting TfR with antibodies, namely, acute clinical signs and decreased circulating reticulocytes observed after dosing. By eliminating Fc effector function, we ameliorated the acute clinical signs and partially rescued a reduction in reticulocytes. Furthermore, we show that complement mediates a residual decrease in reticulocytes observed after Fc effector function is eliminated. These data raise important safety concerns and potential mitigation strategies for the development of TfR-based therapies that are designed to cross the blood-brain barrier.

  1. Expression of antigen tf and galectin-3 in fibroadenoma.

    Science.gov (United States)

    Gallegos, Itandehui Belem; Pérez-Campos, Eduardo; Martinez, Margarito; Mayoral, Miguel Ángel; Pérez, Laura; Aguilar, Sergio; Zenteno, Edgar; Pina, Maria del Socorro; Hernández, Pedro

    2012-12-24

    Fibroadenomas are benign human breast tumors, characterized by proliferation of epithelial and stromal components of the terminal ductal unit. They may grow, regress or remain unchanged, as the hormonal environment of the patient changes. Expression of antigen TF in mucin or mucin-type glycoproteins and of galectin-3 seems to contribute to proliferation and transformations events; their expression has been reported in ductal breast cancer and in aggressive tumors. Lectin histochemistry, immunohistochemistry, and immunofluorescence were used to examine the expression and distribution of antigen TF and galectin-3. We used lectins from Arachis hypogaea, Artocarpus integrifolia, and Amaranthus lecuocarpus to evaluate TF expression and a monoclonal antibody to evaluate galectin-3 expression. We used paraffin-embedded blocks from 10 breast tissues diagnosed with fibroadenoma and as control 10 healthy tissue samples. Histochemical and immunofluorescence analysis showed positive expression of galectin-3 in fibroadenoma tissue, mainly in stroma, weak interaction in ducts was observed; whereas, in healthy tissue samples the staining was also weak in ducts. Lectins from A. leucocarpus and A. integrifolia specificaly recognized ducts in healthy breast samples, whereas the lectin from A. hypogaea recognized ducts and stroma. In fibroadenoma tissue, the lectins from A. integrifolia, A. Hypogaea, and A. leucocarpus recognized mainly ducts. Our results suggest that expression of antigen TF and galectin-3 seems to participate in fibroadenoma development.

  2. Expression of antigen tf and galectin-3 in fibroadenoma

    Directory of Open Access Journals (Sweden)

    Gallegos Itandehui Belem

    2012-12-01

    Full Text Available Abstract Background Fibroadenomas are benign human breast tumors, characterized by proliferation of epithelial and stromal components of the terminal ductal unit. They may grow, regress or remain unchanged, as the hormonal environment of the patient changes. Expression of antigen TF in mucin or mucin-type glycoproteins and of galectin-3 seems to contribute to proliferation and transformations events; their expression has been reported in ductal breast cancer and in aggressive tumors. Findings Lectin histochemistry, immunohistochemistry, and immunofluorescence were used to examine the expression and distribution of antigen TF and galectin-3. We used lectins from Arachis hypogaea, Artocarpus integrifolia, and Amaranthus lecuocarpus to evaluate TF expression and a monoclonal antibody to evaluate galectin-3 expression. We used paraffin-embedded blocks from 10 breast tissues diagnosed with fibroadenoma and as control 10 healthy tissue samples. Histochemical and immunofluorescence analysis showed positive expression of galectin-3 in fibroadenoma tissue, mainly in stroma, weak interaction in ducts was observed; whereas, in healthy tissue samples the staining was also weak in ducts. Lectins from A. leucocarpus and A. integrifolia specificaly recognized ducts in healthy breast samples, whereas the lectin from A. hypogaea recognized ducts and stroma. In fibroadenoma tissue, the lectins from A. integrifolia, A. Hypogaea, and A. leucocarpus recognized mainly ducts. Conclusions Our results suggest that expression of antigen TF and galectin-3 seems to participate in fibroadenoma development.

  3. LCC: Light Curves Classifier

    Science.gov (United States)

    Vo, Martin

    2017-08-01

    Light Curves Classifier uses data mining and machine learning to obtain and classify desired objects. This task can be accomplished by attributes of light curves or any time series, including shapes, histograms, or variograms, or by other available information about the inspected objects, such as color indices, temperatures, and abundances. After specifying features which describe the objects to be searched, the software trains on a given training sample, and can then be used for unsupervised clustering for visualizing the natural separation of the sample. The package can be also used for automatic tuning parameters of used methods (for example, number of hidden neurons or binning ratio). Trained classifiers can be used for filtering outputs from astronomical databases or data stored locally. The Light Curve Classifier can also be used for simple downloading of light curves and all available information of queried stars. It natively can connect to OgleII, OgleIII, ASAS, CoRoT, Kepler, Catalina and MACHO, and new connectors or descriptors can be implemented. In addition to direct usage of the package and command line UI, the program can be used through a web interface. Users can create jobs for ”training” methods on given objects, querying databases and filtering outputs by trained filters. Preimplemented descriptors, classifier and connectors can be picked by simple clicks and their parameters can be tuned by giving ranges of these values. All combinations are then calculated and the best one is used for creating the filter. Natural separation of the data can be visualized by unsupervised clustering.

  4. A new sample treatment for asialo-Tf determination with capillary electrophoresis: an added value to the analysis of CDT.

    Science.gov (United States)

    Porpiglia, Nadia Maria; De Palo, Elio Franco; Savchuk, Sergey Alexandrovich; Appolonova, Svetlana Alexandrovna; Bortolotti, Federica; Tagliaro, Franco

    2018-05-10

    The non-glycosylated glycoform of transferrin (Tf), known as asialo-Tf, was not selected (in favor of disialo-Tf) as the measurand for the standardization of carbohydrate deficient transferrin (CDT) determination because of a lower diagnostic sensitivity provided with the currently available analytical procedures for sera. However, asialo-Tf could provide an additional value to disialo-Tf in the CDT analysis employed in forensic toxicology contexts. The present work aimed at developing an easy sample preparation based on PEG precipitation in order to improve the detectability of asialo-Tf in capillary electrophoresis (CE). Equal volumes (35 μL) of serum and of 30% PEG-8000 were mixed and briefly vortexed. After centrifugation, the supernatant was iron saturated with a ferric solution (1:1, v/v). The mixture was analyzed in CE for asialo-Tf and disialo-Tf determination. PEG-8000 precipitation allowed the improvement of the baseline in the electropherograms in terms of interferences reduction particularly in the asialo-Tf migration region. The detection of asialo-Tf was possible in 89% of samples with disialo-Tf above the cut-off limit, whereas only 16% of them showed asialo-Tf by employing the traditional sample preteatment. Asialo-Tf represents an additional value to disialo-Tf as a biomarker of alcohol abuse in forensic toxicology. Copyright © 2018. Published by Elsevier B.V.

  5. TF insert experiment log book. 2nd Experiment of CS model coil

    International Nuclear Information System (INIS)

    Sugimoto, Makoto; Isono, Takaaki; Matsui, Kunihiro

    2001-12-01

    The cool down of CS model coil and TF insert was started on August 20, 2001. It took almost one month and immediately started coil charge since September 17, 2001. The charge test of TF insert and CS model coil was completed on October 19, 2001. In this campaign, total shot numbers were 88 and the size of the data file in the DAS (Data Acquisition System) was about 4 GB. This report is a database that consists of the log list and the log sheets of every shot. This is an experiment logbook for 2nd experiment of CS model coil and TF insert for charge test. (author)

  6. Pyrolytic graphite as an efficient second-order neutron filter at tuned positions of boundary crossing

    International Nuclear Information System (INIS)

    Adib, M.; Abdel Kawy, A.; Habib, N.; El Mesiry, M.

    2010-01-01

    An investigation of pyrolytic graphite (PG) crystal as an efficient second order neutron filter at tuned boundary crossings has been carried out. The neutron transmission through PG crystal at these tuned crossing points as a function of first- and second-order wavelengths were calculated in terms of PG mosaic spread and thickness. The filtering features of PG crystals at these tuned boundary crossings were deduced. It was shown that, there are a large number of tuned positions at double and triple boundary crossings of the curves (hkl) are very promising as tuned filter positions. However, only fourteen of them are found to be most promising ones. These tuned positions are found to be within the neutron wavelengths from 0.133 up to 0.4050 nm. A computer package GRAPHITE has been used in order to provide the required calculations in the whole neutron wavelength range in terms of PG mosaic spread and its orientation with respect to incident neutron beam direction. It was shown that 0.5 cm thick PG crystal with angular mosaic spread of 2 0 is sufficient to remove 2nd-order neutrons at the wavelengths corresponding to the positions of the intersection boundaries curves (hkl).

  7. FVIIa-sTF and Thrombin Inhibitory Activities of Compounds Isolated from Microcystis aeruginosa K-139

    Directory of Open Access Journals (Sweden)

    Andrea Roxanne J. Anas

    2017-08-01

    Full Text Available The rise of bleeding and bleeding complications caused by oral anticoagulant use are serious problems nowadays. Strategies that block the initiation step in blood coagulation involving activated factor VII-tissue factor (fVIIa-TF have been considered. This study explores toxic Microcystis aeruginosa K-139, from Lake Kasumigaura, Ibaraki, Japan, as a promising cyanobacterium for isolation of fVIIa-sTF inhibitors. M. aeruginosa K-139 underwent reversed-phase solid-phase extraction (ODS-SPE from 20% MeOH to MeOH elution with 40%-MeOH increments, which afforded aeruginosin K-139 in the 60% MeOH fraction; micropeptin K-139 and microviridin B in the MeOH fraction. Aeruginosin K-139 displayed an fVIIa-sTF inhibitory activity of ~166 µM, within a 95% confidence interval. Micropeptin K-139 inhibited fVIIa-sTF with EC50 10.62 µM, which was more efficient than thrombin inhibition of EC50 26.94 µM. The thrombin/fVIIa-sTF ratio of 2.54 in micropeptin K-139 is higher than those in 4-amidinophenylmethane sulfonyl fluoride (APMSF and leupeptin, when used as positive controls. This study proves that M. aeruginosa K-139 is a new source of fVIIa-sTF inhibitors. It also opens a new avenue for micropeptin K-139 and related depsipeptides as fVIIa-sTF inhibitors.

  8. A restructuring of TF package for MIDAS computer code

    International Nuclear Information System (INIS)

    Park, S. H.; Song, Y. M.; Kim, D. H.

    2002-01-01

    TF package which defines some interpolation and extrapolation condition through user defined table has been restructured in MIDAS computer code. To do this, data transferring methods of current MELCOR code are modified and adopted into TF package. The data structure of the current MELCOR code using FORTRAN77 causes a difficult grasping of the meaning of the variables as well as waste of memory. New features of FORTRAN90 make it possible to allocate the storage dynamically and to use the user-defined data type, which lead to an efficient memory treatment and an easy understanding of the code. Restructuring of TF package addressed in this paper does module development and subroutine modification, and treats MELGEN which is making restart file as well as MELCOR which is processing calculation. The validation has been done by comparing the results of the modified code with those from the existing code, and it is confirmed that the results are the same. It hints that the similar approach could be extended to the entire code package. It is expected that code restructuring will accelerate the code domestication thanks to direct understanding of each variable and easy implementation of modified or newly developed models

  9. A Follow-Up Study from a Multisite, Randomized Controlled Trial for Traumatized Children Receiving TF-CBT.

    Science.gov (United States)

    Jensen, Tine K; Holt, Tonje; Ormhaug, Silje M

    2017-11-01

    Trauma-focused cognitive behavioral therapy (TF-CBT) is the treatment of choice for traumatized youth, however, follow-up studies are scarce, and treatment effects for co-occurring depression show mixed findings. The aims of this study were to examine whether treatment effects of TF-CBT are maintained at 18 month follow-up and whether degree of co-occurring depression influences treatment effects. As rapid improvement in psychological functioning is warranted for youth, we also investigated whether the symptom trajectory was different for TF-CBT compared to therapy as usual (TAU). The sample consisted of 156 youth (M age = 15.05, 79.50% girls) randomly assigned to TF-CBT or TAU. The youth were assessed for posttraumatic stress symptoms (PTSS), depression, anxiety and general mental health symptoms. Mixed effects analyses followed the symptom courses over 5 time points. Youth receiving TF-CBT maintained their symptom improvement at 18 months follow-up with scores below clinical cut-of on all symptom measures. The most depressed youth had also a significant decline in symptoms that were maintained at follow-up. Symptom trajectories differed as the TF-CBT group reported a more rapid symptom reduction compared to the TAU condition. In the TAU condition, participants received 1.5 times the number of treatment sessions compared to the TF-CBT participants. After 18 months the groups were significantly different on general mental health symptoms only. In conclusion, youth receiving TF-CBT experienced more efficient improvement in trauma related symptoms than youth receiving TAU and these improvements were maintained after 18 months. Also youth experiencing serious co-occurring depression benefitted from TF-CBT.

  10. From data repositories to submission portals: rethinking the role of domain-specific databases in CollecTF.

    Science.gov (United States)

    Kılıç, Sefa; Sagitova, Dinara M; Wolfish, Shoshannah; Bely, Benoit; Courtot, Mélanie; Ciufo, Stacy; Tatusova, Tatiana; O'Donovan, Claire; Chibucos, Marcus C; Martin, Maria J; Erill, Ivan

    2016-01-01

    Domain-specific databases are essential resources for the biomedical community, leveraging expert knowledge to curate published literature and provide access to referenced data and knowledge. The limited scope of these databases, however, poses important challenges on their infrastructure, visibility, funding and usefulness to the broader scientific community. CollecTF is a community-oriented database documenting experimentally validated transcription factor (TF)-binding sites in the Bacteria domain. In its quest to become a community resource for the annotation of transcriptional regulatory elements in bacterial genomes, CollecTF aims to move away from the conventional data-repository paradigm of domain-specific databases. Through the adoption of well-established ontologies, identifiers and collaborations, CollecTF has progressively become also a portal for the annotation and submission of information on transcriptional regulatory elements to major biological sequence resources (RefSeq, UniProtKB and the Gene Ontology Consortium). This fundamental change in database conception capitalizes on the domain-specific knowledge of contributing communities to provide high-quality annotations, while leveraging the availability of stable information hubs to promote long-term access and provide high-visibility to the data. As a submission portal, CollecTF generates TF-binding site information through direct annotation of RefSeq genome records, definition of TF-based regulatory networks in UniProtKB entries and submission of functional annotations to the Gene Ontology. As a database, CollecTF provides enhanced search and browsing, targeted data exports, binding motif analysis tools and integration with motif discovery and search platforms. This innovative approach will allow CollecTF to focus its limited resources on the generation of high-quality information and the provision of specialized access to the data.Database URL: http://www.collectf.org/. © The Author(s) 2016

  11. TF.Learn: TensorFlow's High-level Module for Distributed Machine Learning

    OpenAIRE

    Tang, Yuan

    2016-01-01

    TF.Learn is a high-level Python module for distributed machine learning inside TensorFlow. It provides an easy-to-use Scikit-learn style interface to simplify the process of creating, configuring, training, evaluating, and experimenting a machine learning model. TF.Learn integrates a wide range of state-of-art machine learning algorithms built on top of TensorFlow's low level APIs for small to large-scale supervised and unsupervised problems. This module focuses on bringing machine learning t...

  12. Gain and frequency tuning within the mouse cochlear apex

    Energy Technology Data Exchange (ETDEWEB)

    Oghalai, John S.; Raphael, Patrick D. [Department of Otolaryngology, Stanford University School of Medicine, Stanford, California (United States); Gao, Simon [Department of Otolaryngology, Stanford University School of Medicine, Stanford, California (United States); Department of Bioengineering, Rice University, Houston, Texas (United States); Lee, Hee Yoon [Department of Otolaryngology, Stanford University School of Medicine, Stanford, California (United States); Department of Electrical Engineering, Stanford University, Stanford, California (United States); Groves, Andrew K. [Department of Neuroscience, Department of Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, Texas (United States); Zuo, Jian [Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee (United States); Applegate, Brian E. [Department of Biomedical Engineering, Texas A& M University, College Station, Texas (United States)

    2015-12-31

    Normal mammalian hearing requires cochlear outer hair cell active processes that amplify the traveling wave with high gain and sharp tuning, termed cochlear amplification. We have used optical coherence tomography to study cochlear amplification within the apical turn of the mouse cochlea. We measured not only classical basilar membrane vibratory tuning curves but also vibratory responses from the rest of the tissues that compose the organ of Corti. Basilar membrane tuning was sharp in live mice and broad in dead mice, whereas other regions of the organ of Corti demonstrated phase shifts consistent with additional filtering beyond that provided by basilar membrane mechanics. We use these experimental data to support a conceptual framework of how cochlear amplification is tuned within the mouse cochlear apex. We will also study transgenic mice with targeted mutations that affect different biomechanical aspects of the organ of Corti in an effort to localize the underlying processes that produce this additional filtering.

  13. Gain and frequency tuning within the mouse cochlear apex

    International Nuclear Information System (INIS)

    Oghalai, John S.; Raphael, Patrick D.; Gao, Simon; Lee, Hee Yoon; Groves, Andrew K.; Zuo, Jian; Applegate, Brian E.

    2015-01-01

    Normal mammalian hearing requires cochlear outer hair cell active processes that amplify the traveling wave with high gain and sharp tuning, termed cochlear amplification. We have used optical coherence tomography to study cochlear amplification within the apical turn of the mouse cochlea. We measured not only classical basilar membrane vibratory tuning curves but also vibratory responses from the rest of the tissues that compose the organ of Corti. Basilar membrane tuning was sharp in live mice and broad in dead mice, whereas other regions of the organ of Corti demonstrated phase shifts consistent with additional filtering beyond that provided by basilar membrane mechanics. We use these experimental data to support a conceptual framework of how cochlear amplification is tuned within the mouse cochlear apex. We will also study transgenic mice with targeted mutations that affect different biomechanical aspects of the organ of Corti in an effort to localize the underlying processes that produce this additional filtering

  14. Mutation in Torenia fournieri Lind. UFO homolog confers loss of TfLFY interaction and results in a petal to sepal transformation.

    Science.gov (United States)

    Sasaki, Katsutomo; Yamaguchi, Hiroyasu; Aida, Ryutaro; Shikata, Masahito; Abe, Tomoko; Ohtsubo, Norihiro

    2012-09-01

    We identified a Torenia fournieri Lind. mutant (no. 252) that exhibited a sepaloid phenotype in which the second whorls were changed to sepal-like organs. This mutant had no stamens, and the floral organs consisted of sepals and carpels. Although the expression of a torenia class B MADS-box gene, GLOBOSA (TfGLO), was abolished in the 252 mutant, no mutation of TfGLO was found. Among torenia homologs such as APETALA1 (AP1), LEAFY (LFY), and UNUSUAL FLORAL ORGANS (UFO), which regulate expression of class B genes in Arabidopsis, only accumulation of the TfUFO transcript was diminished in the 252 mutant. Furthermore, a missense mutation was found in the coding region of the mutant TfUFO. Intact TfUFO complemented the mutant phenotype whereas mutated TfUFO did not; in addition, the transgenic phenotype of TfUFO-knockdown torenias coincided with the mutant phenotype. Yeast two-hybrid analysis revealed that the mutated TfUFO lost its ability to interact with TfLFY protein. In situ hybridization analysis indicated that the transcripts of TfUFO and TfLFY were partially accumulated in the same region. These results clearly demonstrate that the defect in TfUFO caused the sepaloid phenotype in the 252 mutant due to the loss of interaction with TfLFY. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.

  15. The Art and Skill of Delivering Culturally Responsive TF-CBT in Tanzania and Kenya

    Science.gov (United States)

    Kava, Christine M.; Akiba, Christopher F.; Lucid, Leah; Dorsey, Shannon

    2016-01-01

    Objective This study explored the facilitators, barriers, and strategies used to deliver a child mental health evidence-based treatment (EBT), trauma-focused cognitive behavioral therapy (TF-CBT), in a culturally responsive manner. In low- and middle-income countries most individuals with mental health problems do not receive treatment due to a shortage of mental health professionals. One approach to addressing this problem is task-sharing, in which lay counselors are trained to deliver mental health treatment. Combining this approach with a focus on EBT provides a strategy for bridging the mental health treatment gap. However, little is known how about western-developed EBTs are delivered in a culturally responsive manner. Method Semistructured qualitative interviews were conducted with 12 TF-CBT lay counselors involved in a large randomized controlled trial of TF-CBT in Kenya and Tanzania. An inductive approach was used to analyze the data. Results Lay counselors described the importance of being responsive to TF-CBT participants’ customs, beliefs, and socioeconomic conditions and highlighted the value of TF-CBT for their community. They also discussed the importance of partnering with other organizations to address unmet socioeconomic needs. Conclusion The findings from this study provide support for the acceptability and appropriateness of TF-CBT as a treatment approach for improving child mental health. Having a better understanding of the strategies used by lay counselors to ensure that treatment is relevant to the cultural and socioeconomic context of participants can help to inform the implementation of future EBTs. PMID:27414470

  16. Tight aspect ratio tokamak power reactor with superconducting TF coils

    International Nuclear Information System (INIS)

    Nishio, S.; Tobita, K.; Konishi, S.; Ando, T.; Hiroki, S.; Kuroda, T.; Yamauchi, M.; Azumi, M.; Nagata, M.

    2003-01-01

    Tight aspect ratio tokamak power reactor with super-conducting toroidal field (TF) coils has been proposed. A center solenoid coil system and an inboard blanket were discarded. The key point was how to find the engineering design solution of the TF coil system with the high field and high current density. The coil system with the center post radius of less than 1 m can generate the maximum field of ∼ 20 T. This coil system causes a compact reactor concept, where the plasma major and minor radii of 3.75 m and 1.9 m, respectively and the fusion power of 1.8 GW. (author)

  17. Possible dendritic contribution to unimodal numerosity tuning and Weber-Fechner law-dependent numerical cognition

    Directory of Open Access Journals (Sweden)

    Kenji Morita

    2009-08-01

    Full Text Available Humans and animals are known to share an ability to estimate or compare the numerosity of visual stimuli, and this ability is considered to be supported by the cortical neurons that have unimodal tuning for numerosity, referred to as the numerosity detector neurons. How such unimodal numerosity tuning is shaped through plasticity mechanisms is unknown. Here I propose a testable hypothetical mechanism based on recently revealed features of the neuronal dendrite, namely, cooperative plasticity induction and nonlinear input integration at nearby dendritic sites, on the basis of the existing proposal that individual visual stimuli are represented as similar localized activities regardless of the size or the shape in a cortical region in the dorsal visual pathway. Intriguingly, the proposed mechanism naturally explains a prominent feature of the numerosity detector neurons, namely, the broadening of the tuning curve in proportion to the preferred numerosity, which is considered to underlie the known Weber-Fechner law-dependent accuracy of numerosity estimation and comparison. The simulated tuning curves are less sharp than reality, however, and together with the evidence from human imaging studies that numerical representation is a distributed phenomenon, it may not be likely that the proposed mechanism operates by itself. Rather, the proposed mechanism might facilitate the formation of hierarchical circuitry proposed in the previous studies, which includes neurons with monotonic numerosity tuning as well as those with sharp unimodal tuning, by serving as an efficient initial condition.

  18. Peringkasan Sentimen Esktraktif di Twitter Menggunakan Hybrid TF-IDF dan Cosine Similarity

    Directory of Open Access Journals (Sweden)

    Devid Haryalesmana Wahid

    2016-07-01

    Full Text Available The using of Twitter by selebrities has become a new trend of impression management strategy. Mining public reaction in social media is a good strategy to obtain feedbacks, but extracting it are not trivial matter. Reads hundred of tweets while determine their sentiment polarity are time consuming. Extractive sentiment summarization machine are needed to address this issue. Previous research generally do not include sentiment information contained in a tweet as weight factor, as a results only general topics of discussion are extracted. This research aimed to do an extractive sentiment summarization on both positive and negative sentiment mentioning Indonesian selebrity, Agnes Monica, by combining SentiStrength, Hybrid TF-IDF, and Cosine Similarity. SentiStrength is used to obtain sentiment strength score and classify tweet as a positive, negative or neutral. The summarization of posisitve and negative sentiment can be done by rank tweets using Hybrid TF-IDF summarization and sentiment strength score as additional weight then removing similar tweet by using Cosine Similarity. The test results showed that the combination of SentiStrength, Hybrid TF-IDF, and Cosine Similarity perform better than using Hybrid TF-IDF only, given an average 60% accuracy and 62% f-measure. This is due to the addition of sentiment score as a weight factor in sentiment summ­ari­zation.

  19. WISE TF: A MID-INFRARED, 3.4 {mu}m EXTENSION OF THE TULLY-FISHER RELATION USING WISE PHOTOMETRY

    Energy Technology Data Exchange (ETDEWEB)

    Lagattuta, David J.; Mould, Jeremy R. [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, P.O. Box 218, Hawthorn, VIC 3122 (Australia); Staveley-Smith, Lister; Hong Tao; Springob, Christopher M. [ARC Centre of Excellence for All-sky Astrophysics (CAASTRO), Redfern, NSW (Australia); Masters, Karen L. [Institute for Cosmology and Gravitation, University of Portsmouth, Dennis Sciama Building, Burnaby Road, Portsmouth, PO1 3FX (United Kingdom); Koribalski, Baerbel S. [CSIRO Astronomy and Space Science, Australia Telescope National Facility (ATNF) P.O. Box 76, Epping, NSW 1710 (Australia); Jones, D. Heath, E-mail: dlagattu@astro.swin.edu.au [School of Physics, Monash University, Clayton, VIC 3800 (Australia)

    2013-07-10

    We present a mid-infrared Tully-Fisher (TF) relation using photometry from the 3.4 {mu}m W1 band of the Wide-field Infrared Survey Explorer (WISE) satellite. The WISE TF relation is formed from 568 galaxies taken from the all-sky 2MASS Tully-Fisher (2MTF) galaxy catalog, spanning a range of environments including field, group, and cluster galaxies. This constitutes the largest mid-infrared TF relation constructed to date. After applying a number of corrections to galaxy magnitudes and line widths, we measure a master TF relation given by M{sub corr} = -22.24 - 10.05[log (W{sub corr}) - 2.5], with an average dispersion of {sigma}{sub WISE} = 0.686 mag. There is some tension between WISE TF and a preliminary 3.6 {mu}m relation, which has a shallower slope and almost no intrinsic dispersion. However, our results agree well with a more recent relation constructed from a large sample of cluster galaxies. We additionally compare WISE TF to the near-infrared 2MTF template relations, finding a good agreement between the TF parameters and total dispersions of WISE TF and the 2MTF K-band template. This fact, coupled with typical galaxy colors of (K - W1) {approx} 0, suggests that these two bands are tracing similar stellar populations, including the older, centrally-located stars in the galactic bulge which can (for galaxies with a prominent bulge) dominate the light profile.

  20. WISE TF: A MID-INFRARED, 3.4 μm EXTENSION OF THE TULLY-FISHER RELATION USING WISE PHOTOMETRY

    International Nuclear Information System (INIS)

    Lagattuta, David J.; Mould, Jeremy R.; Staveley-Smith, Lister; Hong Tao; Springob, Christopher M.; Masters, Karen L.; Koribalski, Bärbel S.; Jones, D. Heath

    2013-01-01

    We present a mid-infrared Tully-Fisher (TF) relation using photometry from the 3.4 μm W1 band of the Wide-field Infrared Survey Explorer (WISE) satellite. The WISE TF relation is formed from 568 galaxies taken from the all-sky 2MASS Tully-Fisher (2MTF) galaxy catalog, spanning a range of environments including field, group, and cluster galaxies. This constitutes the largest mid-infrared TF relation constructed to date. After applying a number of corrections to galaxy magnitudes and line widths, we measure a master TF relation given by M corr = –22.24 – 10.05[log (W corr ) – 2.5], with an average dispersion of σ WISE = 0.686 mag. There is some tension between WISE TF and a preliminary 3.6 μm relation, which has a shallower slope and almost no intrinsic dispersion. However, our results agree well with a more recent relation constructed from a large sample of cluster galaxies. We additionally compare WISE TF to the near-infrared 2MTF template relations, finding a good agreement between the TF parameters and total dispersions of WISE TF and the 2MTF K-band template. This fact, coupled with typical galaxy colors of (K – W1) ∼ 0, suggests that these two bands are tracing similar stellar populations, including the older, centrally-located stars in the galactic bulge which can (for galaxies with a prominent bulge) dominate the light profile.

  1. Application of [HMim][NTf2], [HMim][TfO] and [BMim][TfO] ionic liquids on the extraction of toluene from alkanes: Effect of the anion and the alkyl chain length of the cation on the LLE

    International Nuclear Information System (INIS)

    Corderí, Sandra; González, Emilio J.; Calvar, Noelia; Domínguez, Ángeles

    2012-01-01

    Highlights: ► Several ionic liquids were studied as solvent to extract toluene from heptane and cyclohexane. ► (Liquid + liquid) equilibrium data were measured at 298.15 K and atmospheric pressure. ► Selectivity and solute distribution ratio were calculated and compared with those found in literature for sulfolane. ► Experimental data were correlated using NRTL and UNIQUAC thermodynamic models. - Abstract: In this paper, the separation of toluene from the aliphatic hydrocarbons heptane and cyclohexane employing the ionic liquids 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, [HMim][NTf 2 ], 1-hexyl-3-methylimidazolium trifluoromethanesulfonate, [HMim][TfO] and 1-butyl-3-methylimidazolium trifluoromethanesulfonate, [BMim][TfO], as solvents was studied and discussed. Liquid–liquid equilibrium data for the ternary systems {heptane, or cyclohexane + toluene + [HMim][NTf 2 ], or [HMim][TfO], or [BMim][TfO]} and {heptane + cyclohexane + [HMim][NTf 2 ], or [HMim][TfO], or [BMim][TfO]} were measured at T = 298.15 K and atmospheric pressure. The degree of consistency of the tie-lines was tested using the Othmer–Tobias equation. The solute distribution ratio and selectivity, derived from the experimental tie-lines, were used to determine if these ionic liquids can be used as potential solvents on the extraction of toluene from aliphatic hydrocarbons; a comparison with literature data where sulfolane is used as solvent was also included. Finally, the experimental data were correlated with the NRTL and UNIQUAC thermodynamic models.

  2. Spontaneous otoacoustic emissions, threshold microstructure, and psychophysical tuning over a wide frequency range in humansa

    Science.gov (United States)

    Baiduc, Rachael R.; Lee, Jungmee; Dhar, Sumitrajit

    2014-01-01

    Hearing thresholds have been shown to exhibit periodic minima and maxima, a pattern known as threshold microstructure. Microstructure has previously been linked to spontaneous otoacoustic emissions (SOAEs) and normal cochlear function. However, SOAEs at high frequencies (>4 kHz) have been associated with hearing loss or cochlear pathology in some reports. Microstructure would not be expected near these high-frequency SOAEs. Psychophysical tuning curves (PTCs), the expression of frequency selectivity, may also be altered by SOAEs. Prior comparisons of tuning between ears with and without SOAEs demonstrated sharper tuning in ears with emissions. Here, threshold microstructure and PTCs were compared at SOAE frequencies ranging between 1.2 and 13.9 kHz using subjects without SOAEs as controls. Results indicate: (1) Threshold microstructure is observable in the vicinity of SOAEs of all frequencies; (2) PTCs are influenced by SOAEs, resulting in shifted tuning curve tips, multiple tips, or inversion. High frequency SOAEs show a greater effect on PTC morphology. The influence of most SOAEs at high frequencies on threshold microstructure and PTCs is consistent with those at lower frequencies, suggesting that high-frequency SOAEs reflect the same cochlear processes that lead to SOAEs at lower frequencies. PMID:24437770

  3. A Method to Predict Compressor Stall in the TF34-100 Turbofan Engine Utilizing Real-Time Performance Data

    Science.gov (United States)

    2015-06-01

    A METHOD TO PREDICT COMPRESSOR STALL IN THE TF34-100 TURBOFAN ENGINE UTILIZING REAL-TIME PERFORMANCE...THE TF34-100 TURBOFAN ENGINE UTILIZING REAL-TIME PERFORMANCE DATA THESIS Presented to the Faculty Department of Systems Engineering and...036 A METHOD TO PREDICT COMPRESSOR STALL IN THE TF34-100 TURBOFAN ENGINE UTILIZING REAL-TIME PERFORMANCE DATA Shuxiang ‘Albert’ Li, BS

  4. Cobra-TF simulation of BWR bundle dry out experiments

    Energy Technology Data Exchange (ETDEWEB)

    Frepoli, C.; Ireland, A.; Hochreiter, L.; Ivanov, K. [Penn State Univ., Dept. of Mechanical and Nuclear Engineering, University Park, PA (United States); Velten, R. [Siemens Nuclear Power GmbH, Erlangen (Germany)

    2001-07-01

    The COBRA-TF computer code uses a two-fluid, three-field and three-dimensional formulation to model a two-phase flow field in a specific geometry. The liquid phase is divided in a continuous liquid field and a separate dispersed field, which is used to describe the entrained liquid drops. For each space dimension, the code solves three momentum equations, three mass conservation equations and two energy conservation equations. Entrainment and depositions models are implemented into the code to model the mass transfer between the two liquid fields. This study presents the results obtained with COBRA-TF for the simulation of the Siemens 9-9Q BWR Bundle Dryout experiments. The model includes 20 channels and 34 axial nodes in the heated section. The predicted critical power and dryout location is compared with the measured values. An assessment of the code entrainment and de-entrainment models is presented. (authors)

  5. An efficient automated parameter tuning framework for spiking neural networks.

    Science.gov (United States)

    Carlson, Kristofor D; Nageswaran, Jayram Moorkanikara; Dutt, Nikil; Krichmar, Jeffrey L

    2014-01-01

    As the desire for biologically realistic spiking neural networks (SNNs) increases, tuning the enormous number of open parameters in these models becomes a difficult challenge. SNNs have been used to successfully model complex neural circuits that explore various neural phenomena such as neural plasticity, vision systems, auditory systems, neural oscillations, and many other important topics of neural function. Additionally, SNNs are particularly well-adapted to run on neuromorphic hardware that will support biological brain-scale architectures. Although the inclusion of realistic plasticity equations, neural dynamics, and recurrent topologies has increased the descriptive power of SNNs, it has also made the task of tuning these biologically realistic SNNs difficult. To meet this challenge, we present an automated parameter tuning framework capable of tuning SNNs quickly and efficiently using evolutionary algorithms (EA) and inexpensive, readily accessible graphics processing units (GPUs). A sample SNN with 4104 neurons was tuned to give V1 simple cell-like tuning curve responses and produce self-organizing receptive fields (SORFs) when presented with a random sequence of counterphase sinusoidal grating stimuli. A performance analysis comparing the GPU-accelerated implementation to a single-threaded central processing unit (CPU) implementation was carried out and showed a speedup of 65× of the GPU implementation over the CPU implementation, or 0.35 h per generation for GPU vs. 23.5 h per generation for CPU. Additionally, the parameter value solutions found in the tuned SNN were studied and found to be stable and repeatable. The automated parameter tuning framework presented here will be of use to both the computational neuroscience and neuromorphic engineering communities, making the process of constructing and tuning large-scale SNNs much quicker and easier.

  6. BOREAS TF-02 SSA-OA Tethersonde Meteorological and Ozone Data

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: The BOREAS TF-02 team collected various trace gas and energy flux data along with meteorological parameters at the SSA-OA site. This data set contains...

  7. BOREAS TF-02 SSA-OA Tethersonde Meteorological and Ozone Data

    Data.gov (United States)

    National Aeronautics and Space Administration — The BOREAS TF-02 team collected various trace gas and energy flux data along with meteorological parameters at the SSA-OA site. This data set contains meteorological...

  8. Magnetic field shielding effect for CFETR TF coil-case

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Weiwei; Liu, Xufeng, E-mail: Lxf@ipp.ac.cn; Du, Shuangsong; Zheng, Jinxing

    2017-05-15

    Highlights: • The eddy current of CFETR vacuum vessel can be calculated by using a series of ideal current loops. • The shielding effect with different eddy current is studied by decomposing the exciting magnetic field as two orthogonal components. • The shielding effect can be determined from the rate of eddy current magnetic field to the external magnetic field. - Abstract: The operation of superconducting magnet for fusion device is under the complex magnetic field condition, which affect the stabilization of superconductor. The coil-case of TF coil can shield the magnetic field to some extent. The shielding effect is related to the eddy current of coil-case. The shielding effect with different eddy current is studied by decomposing the exciting magnetic field as two orthogonal components, respectively. The results indicate that the shielding effect of CFETR TF coil-case has obvious different with the different directional magnetic field, and it’s larger for tangential magnetic compared with that for normal field.

  9. Cis-regulatory control of the nuclear receptor Coup-TF gene in the sea urchin Paracentrotus lividus embryo.

    Directory of Open Access Journals (Sweden)

    Lamprini G Kalampoki

    Full Text Available Coup-TF, an orphan member of the nuclear receptor super family, has a fundamental role in the development of metazoan embryos. The study of the gene's regulatory circuit in the sea urchin embryo will facilitate the placement of this transcription factor in the well-studied embryonic Gene Regulatory Network (GRN. The Paracentrotus lividus Coup-TF gene (PlCoup-TF is expressed throughout embryonic development preferentially in the oral ectoderm of the gastrula and the ciliary band of the pluteus stage. Two overlapping λ genomic clones, containing three exons and upstream sequences of PlCoup-TF, were isolated from a genomic library. The transcription initiation site was determined and 5' deletions and individual segments of a 1930 bp upstream region were placed ahead of a GFP reporter cassette and injected into fertilized P.lividus eggs. Module a (-532 to -232, was necessary and sufficient to confer ciliary band expression to the reporter. Comparison of P.lividus and Strongylocentrotus purpuratus upstream Coup-TF sequences, revealed considerable conservation, but none within module a. 5' and internal deletions into module a, defined a smaller region that confers ciliary band specific expression. Putative regulatory cis-acting elements (RE1, RE2 and RE3 within module a, were specifically bound by proteins in sea urchin embryonic nuclear extracts. Site-specific mutagenesis of these elements resulted in loss of reporter activity (RE1 or ectopic expression (RE2, RE3. It is proposed that sea urchin transcription factors, which bind these three regulatory sites, are necessary for spatial and quantitative regulation of the PlCoup-TF gene at pluteus stage sea urchin embryos. These findings lead to the future identification of these factors and to the hierarchical positioning of PlCoup-TF within the embryonic GRN.

  10. Parallelized preconditioned BiCGStab solution of sparse linear system equations in F-COBRA-TF

    International Nuclear Information System (INIS)

    Geemert, Rene van; Glück, Markus; Riedmann, Michael; Gabriel, Harry

    2011-01-01

    Recently, the in-house development of a preconditioned and parallelized BiCGStab solver has been pursued successfully in AREVA’s advanced sub-channel code F-COBRA-TF. This solver can be run either in a sequential computation mode on a single CPU, or in a parallel computation mode on multiple parallel CPUs. The developed procedure enables the computation of several thousands of successive sparse linear system solutions in F-COBRA-TF with acceptable wall clock run times. The current paper provides general information about F-COBRA-TF in terms of modeling capabilities and application areas, and points out where the relevance arises for the efficient iterative solution of sparse linear systems. Furthermore, the preconditioning and parallelization strategies in the developed BiCGStab iterative solution approach are discussed. The paper is concluded with a number of verification examples. (author)

  11. Estimation of Theaflavins (TF) and Thearubigins (TR) Ratio in Black Tea Liquor Using Electronic Vision System

    Science.gov (United States)

    Akuli, Amitava; Pal, Abhra; Ghosh, Arunangshu; Bhattacharyya, Nabarun; Bandhopadhyya, Rajib; Tamuly, Pradip; Gogoi, Nagen

    2011-09-01

    Quality of black tea is generally assessed using organoleptic tests by professional tea tasters. They determine the quality of black tea based on its appearance (in dry condition and during liquor formation), aroma and taste. Variation in the above parameters is actually contributed by a number of chemical compounds like, Theaflavins (TF), Thearubigins (TR), Caffeine, Linalool, Geraniol etc. Among the above, TF and TR are the most important chemical compounds, which actually contribute to the formation of taste, colour and brightness in tea liquor. Estimation of TF and TR in black tea is generally done using a spectrophotometer instrument. But, the analysis technique undergoes a rigorous and time consuming effort for sample preparation; also the operation of costly spectrophotometer requires expert manpower. To overcome above problems an Electronic Vision System based on digital image processing technique has been developed. The system is faster, low cost, repeatable and can estimate the amount of TF and TR ratio for black tea liquor with accuracy. The data analysis is done using Principal Component Analysis (PCA), Multiple Linear Regression (MLR) and Multiple Discriminate Analysis (MDA). A correlation has been established between colour of tea liquor images and TF, TR ratio. This paper describes the newly developed E-Vision system, experimental methods, data analysis algorithms and finally, the performance of the E-Vision System as compared to the results of traditional spectrophotometer.

  12. Beam tuning parameters for the Kolkata superconducting cyclotron

    International Nuclear Information System (INIS)

    Debnath, J.; Dey, M.K.; Paul, S.; Pradhan, J.; Bhunia, U.; Dutta, A.; Agrawal, A.; Naser, Md. Z.A.; Rashid, M.H.; Mallik, C.; Bhandari, R.K.

    2009-01-01

    The internal beam tuning in the Superconducting cyclotron at VECC will be started very soon. The magnetic field data has been used to explore the beam dynamical issues. There are two main coils and fourteen no. of trim coils. The optimised main coil and trim coil current settings for producing the required near-isochronous field fitting suitable phase-energy curve to accelerate different ion species in the operating region with minimum trim coil power as well as minimum error in the energy-phase curve have been calculated and reported here. The equilibrium orbit properties i.e., the radial and axial focusing frequencies, frequency error, integrated phase shift etc. have been studied. The important issues related to beam deliverables are explored. (author)

  13. Design and implementation of quench detection instrumentation for TF magnet system of SST-1

    International Nuclear Information System (INIS)

    Khristi, Y.; Sharma, A.N.; Doshi, K.; Banaudha, M.; Prasad, U.; Varmora, P.; Patel, D.; Pradhan, S.

    2014-01-01

    Steady State Superconducting Tokamak-1 (SST-1) at Institute for Plasma Research (IPR), India is now in engineering validation phase. The assembled Toroidal Field (TF) magnet system of SST-1 will be operated at 10 kA of nominal current at helium cooled condition of 4.5 K. A reliable and fail proof quench detection (QD) system is essential for the safety and the investment protection requirements of the magnets. This QD system needs to continuously monitor all the superconducting coils, which include 16 TF magnets, return-loop, bus bars and current leads. In case of any event initiating the normal resistive zone and reaching thermal run-away, the QD system needs to trigger the magnet protection circuits. Precision instrumentation and control system with 204 signal channels had been developed for detection of quench anywhere in the entire TF magnet system. In the present configuration of quench detection scheme, the voltage drop across each double pancake (DP) of each TF coil are compared with its two adjacent DPs for the detection of normal zone and cancelation of inductive couples. Two identical redundant systems with one out of two configurations are successfully commissioned and tested at IPR. This paper describes the design and implementation of the QD system, Installation experience, validation test and initial results from the recent SST-1 magnet system charging

  14. Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway in Vitro and in a Rodent Model

    Directory of Open Access Journals (Sweden)

    Hongchen Ji

    2015-05-01

    Full Text Available Background: The activation of tissue factor (TF is one of the major reasons for coagulation dysregulation after pig-to-primate xenotransplantation. Tissue factor pathway inhibitor (TFPI is the most important inhibitor of TF. Studies have demonstrated species incompatibility between pig TFPI and human TF. Methods: A pig-to-macaque heterotopic auxiliary liver transplantation model was established to determine the origin of activated TF. Chimeric proteins of human and pig TFPI were constructed to assess the role of Kunitz domains in species incompatibility. Immortalised pig bone marrow mesenchymal stem cells transfected with human TFPI were tested for their ability to inhibit clotting in vitro. Results: TF from recipient was activated early after liver xenotransplantation. Pig TFPI Kunitz domain 2 bound human FXa, but Kunitz domain 1 did not effectively inhibit human TF/FVIIa. Immortalised pig bone marrow mesenchymal cells (BMSCs transfected with human TFPI showed a prolonged recalcification time in vitro and in a rodent model. Conclusion: Recipient TF is relevant to dysregulated coagulation after xenotransplantation. Kunitz domain 1 plays the most important role in species incompatibility between pig TFPI and human TF, and clotting can be inhibited by human TFPI-transfected pig BMSCs. Our study shows a possible way to resolve the incompatibility of pig TFPI.

  15. Neural Tuning Functions Underlie Both Generalization and Interference.

    Directory of Open Access Journals (Sweden)

    Ian S Howard

    Full Text Available In sports, the role of backswing is considered critical for generating a good shot, even though it plays no direct role in hitting the ball. We recently demonstrated the scientific basis of this phenomenon by showing that immediate past movement affects the learning and recall of motor memories. This effect occurred regardless of whether the past contextual movement was performed actively, passively, or shown visually. In force field studies, it has been shown that motor memories generalize locally and that the level of compensation decays as a function of movement angle away from the trained movement. Here we examine if the contextual effect of past movement exhibits similar patterns of generalization and whether it can explain behavior seen in interference studies. Using a single force-field learning task, the directional tuning curves of both the prior contextual movement and the subsequent force field adaptive movements were measured. The adaptation movement direction showed strong directional tuning, decaying to zero by 90° relative to the training direction. The contextual movement direction exhibited a similar directional tuning, although the effect was always above 60%. We then investigated the directional tuning of the passive contextual movement using interference tasks, where the contextual movements that uniquely specified the force field direction were separated by ±15° or ±45°. Both groups showed a pronounced tuning effect, which could be well explained by the directional tuning functions for single force fields. Our results show that contextual effect of past movement influences predictive force compensation, even when adaptation does not require contextual information. However, when such past movement contextual information is crucial to the task, such as in an interference study, it plays a strong role in motor memory learning and recall. This work demonstrates that similar tuning responses underlie both generalization of

  16. Spontaneous regression of curve in immature idiopathic scoliosis - does spinal column play a role to balance? An observation with literature review

    Directory of Open Access Journals (Sweden)

    Modi Hitesh N

    2010-11-01

    Full Text Available Abstract Background Child with mild scoliosis is always a subject of interest for most orthopaedic surgeons regarding progression. Literature described Hueter-Volkmann theory regarding disc and vertebral wedging, and muscular imbalance for the progression of adolescent idiopathic scoliosis. However, many authors reported spontaneous resolution of curves also without any reason for that and the rate of resolution reported is almost 25%. Purpose of this study was to question the role of paraspinal muscle tuning/balancing mechanism, especially in patients with idiopathic scoliosis with early mild curve, for spontaneous regression or progression as well as changing pattern of curves. Methods An observational study of serial radiograms in 169 idiopathic scoliosis children (with minimum follow-up one year was carried. All children with Cobb angle Results Average age was 9.2 years at first visit and 10.11 years at final follow-up with an average follow-up of 21 months. 32.5% (55/169, 41.4% (70/169 and 26% (44/169 children exhibited regression, no change and progression in their curves, respectively. 46.1% of children (78/169 showed changing pattern of their curves during the follow-up visits before it settled down to final curve. Comparing final fate of curve with side of curve and number of curves it did not show any relationship (p > 0.05 in our study population. Conclusion Possible reason for changing patterns could be better explained by the tuning/balancing mechanism of spinal column that makes an effort to balance the spine and result into spontaneous regression or prevent further progression of curve. If this which we called as "tuning/balancing mechanism" fails, curve will ultimately progress.

  17. Spontaneous regression of curve in immature idiopathic scoliosis - does spinal column play a role to balance? An observation with literature review.

    Science.gov (United States)

    Modi, Hitesh N; Suh, Seung-Woo; Yang, Jae-Hyuk; Hong, Jae-Young; Venkatesh, Kp; Muzaffar, Nasir

    2010-11-04

    Child with mild scoliosis is always a subject of interest for most orthopaedic surgeons regarding progression. Literature described Hueter-Volkmann theory regarding disc and vertebral wedging, and muscular imbalance for the progression of adolescent idiopathic scoliosis. However, many authors reported spontaneous resolution of curves also without any reason for that and the rate of resolution reported is almost 25%. Purpose of this study was to question the role of paraspinal muscle tuning/balancing mechanism, especially in patients with idiopathic scoliosis with early mild curve, for spontaneous regression or progression as well as changing pattern of curves. An observational study of serial radiograms in 169 idiopathic scoliosis children (with minimum follow-up one year) was carried. All children with Cobb angle change and progression of their curves, respectively. Additionally changes in the pattern of curve were also noted. Average age was 9.2 years at first visit and 10.11 years at final follow-up with an average follow-up of 21 months. 32.5% (55/169), 41.4% (70/169) and 26% (44/169) children exhibited regression, no change and progression in their curves, respectively. 46.1% of children (78/169) showed changing pattern of their curves during the follow-up visits before it settled down to final curve. Comparing final fate of curve with side of curve and number of curves it did not show any relationship (p > 0.05) in our study population. Possible reason for changing patterns could be better explained by the tuning/balancing mechanism of spinal column that makes an effort to balance the spine and result into spontaneous regression or prevent further progression of curve. If this which we called as "tuning/balancing mechanism" fails, curve will ultimately progress.

  18. Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice

    Energy Technology Data Exchange (ETDEWEB)

    Sur, Subhayan, E-mail: subhayansur18@gmail.com [Dept. of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, West Bengal (India); Pal, Debolina; Roy, Rituparna; Barua, Atish [Dept. of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, West Bengal (India); Roy, Anup [North Bengal Medical College and Hospital, West Bengal (India); Saha, Prosenjit [Dept. of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, West Bengal (India); Panda, Chinmay Kumar, E-mail: ckpanda.cnci@gmail.com [Dept. of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, West Bengal (India)

    2016-06-01

    The aim of this study is to understand the molecular mechanisms of N-nitrosodiethylamine (NDEA) induced multi-organ carcinogenesis in tongue and liver of the same mouse and restriction of carcinogenesis by Epigallocatechin gallate (EGCG) and Theaflavin (TF), if any. For that purpose, cellular proliferation/apoptosis, prevalence of CD44 positive stem cell population and expressions of some key regulatory genes of self renewal Wnt and Hedgehog (Hh) pathways and some of their associated genes were analyzed in the NDEA induced tongue and liver lesions in absence or presence of EGCG/TF. Chronic NDEA exposure in oral cavity could decrease mice body weights and induce tongue and liver carcinogenesis with similar histological stages (severe dysplasia up to 30th weeks of NDEA administration). Increasing mice body weights were seen in continuous and post EGCG/TF treated groups. EGCG/TF treatment could restrict both the carcinogenesis at similar histological stages showing potential chemopreventive effect in continuous treated groups (mild dysplasia) followed by pre treatment (moderate dysplasia) and therapeutic efficacy in post treated groups (mild dysplasia) up to 30th week. The mechanism of carcinogenesis by NDEA and restriction by the EGCG/TF in both tongue and liver were similar and found to be associated with modulation in cellular proliferation/apoptosis and prevalence of CD44 positive population. The up-regulation of self renewal Wnt/β-catenin, Hh/Gli1 pathways and their associated genes Cyclin D1, cMyc and EGFR along with down regulation of E-cadherin seen during the carcinogenesis processes were found to be modulated during the restriction processes by EGCG/TF. - Highlights: • Simultaneous tongue and liver carcinogenesis in mice by oral NDEA administration • Restriction of both carcinogenesis by EGCG and TF at early pre-malignant stages • The mechanisms of carcinogenesis and restriction were similar in both the organs. • Changes in proliferation

  19. Tea polyphenols EGCG and TF restrict tongue and liver carcinogenesis simultaneously induced by N-nitrosodiethylamine in mice

    International Nuclear Information System (INIS)

    Sur, Subhayan; Pal, Debolina; Roy, Rituparna; Barua, Atish; Roy, Anup; Saha, Prosenjit; Panda, Chinmay Kumar

    2016-01-01

    The aim of this study is to understand the molecular mechanisms of N-nitrosodiethylamine (NDEA) induced multi-organ carcinogenesis in tongue and liver of the same mouse and restriction of carcinogenesis by Epigallocatechin gallate (EGCG) and Theaflavin (TF), if any. For that purpose, cellular proliferation/apoptosis, prevalence of CD44 positive stem cell population and expressions of some key regulatory genes of self renewal Wnt and Hedgehog (Hh) pathways and some of their associated genes were analyzed in the NDEA induced tongue and liver lesions in absence or presence of EGCG/TF. Chronic NDEA exposure in oral cavity could decrease mice body weights and induce tongue and liver carcinogenesis with similar histological stages (severe dysplasia up to 30th weeks of NDEA administration). Increasing mice body weights were seen in continuous and post EGCG/TF treated groups. EGCG/TF treatment could restrict both the carcinogenesis at similar histological stages showing potential chemopreventive effect in continuous treated groups (mild dysplasia) followed by pre treatment (moderate dysplasia) and therapeutic efficacy in post treated groups (mild dysplasia) up to 30th week. The mechanism of carcinogenesis by NDEA and restriction by the EGCG/TF in both tongue and liver were similar and found to be associated with modulation in cellular proliferation/apoptosis and prevalence of CD44 positive population. The up-regulation of self renewal Wnt/β-catenin, Hh/Gli1 pathways and their associated genes Cyclin D1, cMyc and EGFR along with down regulation of E-cadherin seen during the carcinogenesis processes were found to be modulated during the restriction processes by EGCG/TF. - Highlights: • Simultaneous tongue and liver carcinogenesis in mice by oral NDEA administration • Restriction of both carcinogenesis by EGCG and TF at early pre-malignant stages • The mechanisms of carcinogenesis and restriction were similar in both the organs. • Changes in proliferation

  20. BOREAS TF-06 SSA-YA Surface Energy Flux and Meteorological Data

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: Contains meteorology data collected at the SSA-YA tower flux site by the TF6 group. These data were reported at 10 minute intervals. The flux and ancillary...

  1. Cryogenic analysis of forced-cooled, superconducting TF magnets for compact tokamak reactors

    International Nuclear Information System (INIS)

    Kerns, J.A.; Slack, D.S.; Miller, J.R.

    1988-01-01

    Current designs for compact tokamak reactors require the toroidal- field (TF) superconducting magnets to produce fields from 10 to 15 T at the winding pack, using high-current densities to high nuclear heat loads (greater than 1 kW/coil in some instances), which are significantly greater than the conduction and radiation heat loads for which cryogenic systems are usually designed. A cryogenic system for the TF winding pack for two such tokamak designs has been verified by performing a detailed, steady-state heat-removal analysis. Helium properties along the forced-cooled conductor flow path for a range of nuclear heat loads have been calculated. The results and implications of this analysis are presented. 12 refs., 6 figs

  2. Comparative Evaluation of Tubex TF (Inhibition Magnetic Binding Immunoassay) for Typhoid Fever in Endemic Area.

    Science.gov (United States)

    Khanna, Ashish; Khanna, Menka; Gill, Karamjit Singh

    2015-11-01

    Typhoid fever remains a significant health problem in endemic countries like India. Various serological tests for the diagnosis of typhoid fever are available commercially. We assessed the usefulness of rapid test based on magnetic particle separation to detect Immunoglobulin against Salmonella typhi O9 lipopolysaccharide. Aim of this study was to compare the sensitivity and specificity of widal test, typhidot and tubex TF test for the diagnosis of typhoid fever in an endemic country like India. Serum samples collected from 50 patients of typhoid fever, 50 patients of non typhoid fever and 100 normal healthy individuals residing in Amritsar were subjected to widal test, typhidot test and tubex TF test as per manufacturer's instructions. Data collected was assessed to find sensitivity and specificity of these tests in an endemic area. Significant widal test results were found positive in 68% of patients of typhoid fever and only 4% of non typhoid fever patients. Typhidot (IgM or IgG) was positive in 72% of typhoid fever patients and 10% and 6% in non typhoid fever and normal healthy individuals respectively. Tubex TF showed higher sensitivity of 76% and specificity of 96-99% which was higher than typhidot and comparable to widal test. This was the first evaluation of rapid tubex TF test in northern India. In countries which can afford high cost of test, tubex TF should be recommended for the diagnosis in acute stage of the disease in clinical setting. However, there is urgent need for a highly specific and sensitive test for the diagnosis of typhoid fever in clinical settings in endemic areas.

  3. Differences between mechanical and neural tuning at the apex of the intact guinea pig cochlea

    Science.gov (United States)

    Recio-Spinoso, Alberto; Oghalai, John S.

    2018-05-01

    While most of human speech information is contained within frequencies guinea pig cochlea using volumetric optical coherence tomography vibrometry (VOCTV). We found that vibrations within apical cochlear regions, with neural tuning below 2 kHz, demonstrate low-pass filter characteristics. There was evidence of a low-level of broad-band cochlear amplification that did not sharpen frequency selectivity. We compared the vibratory responses we measured to previously-measured single-unit auditory nerve tuning curves in the same frequency range, and found that mechanical responses do not match neural responses. These data suggest that, for low frequency cochlear regions, inner hair cells not only transduce vibrations of the organ of Corti but also sharpen frequency tuning.

  4. FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cells.

    Science.gov (United States)

    Bourseguin, Julie; Bonet, Caroline; Renaud, Emilie; Pandiani, Charlotte; Boncompagni, Marina; Giuliano, Sandy; Pawlikowska, Patrycja; Karmous-Benailly, Houda; Ballotti, Robert; Rosselli, Filippo; Bertolotto, Corine

    2016-11-09

    Proteins involved in genetic stability maintenance and safeguarding DNA replication act not only against cancer initiation but could also play a major role in sustaining cancer progression. Here, we report that the FANC pathway is highly expressed in metastatic melanoma harboring the oncogenic microphthalmia-associated transcription factor (MiTF). We show that MiTF downregulation in melanoma cells lowers the expression of several FANC genes and proteins. Moreover, we observe that, similarly to the consequence of MiTF downregulation, FANC pathway silencing alters proliferation, migration and senescence of human melanoma cells. We demonstrate that the FANC pathway acts downstream MiTF and establish the existence of an epistatic relationship between MiTF and the FANC pathway. Our findings point to a central role of the FANC pathway in cellular and chromosomal resistance to both DNA damage and targeted therapies in melanoma cells. Thus, the FANC pathway is a promising new therapeutic target in melanoma treatment.

  5. Searching for the annual modulation of dark matter signal with the GENIUS-TF experiment

    International Nuclear Information System (INIS)

    Tomei, C.; Dietz, A.; Krivosheina, I.; Klapdor-Kleingrothaus, H.V.

    2003-01-01

    The annual modulation of the recoil spectrum observed in an underground detector is well known as the main signature of a possible WIMP signal. The GENIUS-TF experiment, under construction in the Gran Sasso National Laboratory, can search for the annual modulation of the Dark Matter signal using 40 kg of naked-Ge detectors in liquid nitrogen. Starting from a set of data simulated under the hypothesis of modulation and using different methods, we show the potential of GENIUS-TF for extracting the modulated signal and the expected WIMP mass and WIMP cross-section

  6. Identifying TF-MiRNA Regulatory Relationships Using Multiple Features.

    Directory of Open Access Journals (Sweden)

    Mingyu Shao

    Full Text Available MicroRNAs are known to play important roles in the transcriptional and post-transcriptional regulation of gene expression. While intensive research has been conducted to identify miRNAs and their target genes in various genomes, there is only limited knowledge about how microRNAs are regulated. In this study, we construct a pipeline that can infer the regulatory relationships between transcription factors and microRNAs from ChIP-Seq data with high confidence. In particular, after identifying candidate peaks from ChIP-Seq data, we formulate the inference as a PU learning (learning from only positive and unlabeled examples problem. Multiple features including the statistical significance of the peaks, the location of the peaks, the transcription factor binding site motifs, and the evolutionary conservation are derived from peaks for training and prediction. To further improve the accuracy of our inference, we also apply a mean reciprocal rank (MRR-based method to the candidate peaks. We apply our pipeline to infer TF-miRNA regulatory relationships in mouse embryonic stem cells. The experimental results show that our approach provides very specific findings of TF-miRNA regulatory relationships.

  7. Tuning of automatic exposure control strength in lumbar spine CT.

    Science.gov (United States)

    D'Hondt, A; Cornil, A; Bohy, P; De Maertelaer, V; Gevenois, P A; Tack, D

    2014-05-01

    To investigate the impact of tuning the automatic exposure control (AEC) strength curve (specific to Care Dose 4D®; Siemens Healthcare, Forchheim, Germany) from "average" to "strong" on image quality, radiation dose and operator dependency during lumbar spine CT examinations. Two hospitals (H1, H2), both using the same scanners, were considered for two time periods (P1 and P2). During P1, the AEC curve was "average" and radiographers had to select one of two protocols according to the body mass index (BMI): "standard" if BMI 30.0 kg m(-2) (140 kV-280 mAs). During P2, the AEC curve was changed to "strong", and all acquisitions were obtained with one protocol (120 kV and 270 mAs). Image quality was scored and patients' diameters calculated for both periods. 497 examinations were analysed. There was no significant difference in mean diameters according to hospitals and periods (p > 0.801) and in quality scores between periods (p > 0.172). There was a significant difference between hospitals regarding how often the "large" protocol was assigned [13 (10%)/132 patients in H1 vs 37 (28%)/133 in H2] (p < 0.001). During P1, volume CT dose index (CTDIvol) was higher in H2 (+13%; p = 0.050). In both hospitals, CTDIvol was reduced between periods (-19.2% in H1 and -29.4% in H2; p < 0.001). An operator dependency in protocol selection, unexplained by patient diameters or highlighted by image quality scores, has been observed. Tuning the AEC curve from average to strong enables suppression of the operator dependency in protocol selection and related dose increase, while preserving image quality. CT acquisition protocols based on weight are responsible for biases in protocol selection. Using an appropriate AEC strength curve reduces the number of protocols to one. Operator dependency of protocol selection is thereby eliminated.

  8. Re-tuning tuned mass dampers using ambient vibration measurements

    International Nuclear Information System (INIS)

    Hazra, B; Sadhu, A; Narasimhan, S; Lourenco, R

    2010-01-01

    Deterioration, accidental changes in the operating conditions, or incorrect estimates of the structure modal properties lead to de-tuning in tuned mass dampers (TMDs). To restore optimal performance, it is necessary to estimate the modal properties of the system, and re-tune the TMD to its optimal state. The presence of closely spaced modes and a relatively large amount of damping in the dominant modes renders the process of identification difficult. Furthermore, the process of estimating the modal properties of the bare structure using ambient vibration measurements of the structure with the TMD is challenging. In order to overcome these challenges, a novel identification and re-tuning algorithm is proposed. The process of identification consists of empirical mode decomposition to separate the closely spaced modes, followed by the blind identification of the remaining modes. Algorithms for estimating the fundamental frequency and the mode shape of the primary structure necessary for re-tuning the TMD are proposed. Experimental results from the application of the proposed algorithms to identify and re-tune a laboratory structure TMD system are presented

  9. Nonlinear dynamics of a pulse-coupled neural oscillator model of orientation tuning in the visual cortex

    International Nuclear Information System (INIS)

    Bressloff, P.C.; Bressloff, N.W.

    2000-01-01

    Orientation tuning in a ring of pulse-coupled integrate-and-fire (IF) neurons is analyzed in terms of spontaneous pattern formation. It is shown how the ring bifurcates from a synchronous state to a non-phase-locked state whose spike trains are characterized by quasiperiodic variations of the inter-spike intervals (ISIs) on closed invariant circles. The separation of these invariant circles in phase space results in a localized peak of activity as measured by the time-averaged firing rate of the neurons. This generates a sharp orientation tuning curve that can lock to a slowly rotating, weakly tuned external stimulus. For fast synapses, breakup of the quasiperiodic orbits occurs leading to high spike time variability suggestive of chaos

  10. Nonlinear dynamics of a pulse-coupled neural oscillator model of orientation tuning in the visual cortex

    Science.gov (United States)

    Bressloff, P. C.; Bressloff, N. W.

    2000-02-01

    Orientation tuning in a ring of pulse-coupled integrate-and-fire (IF) neurons is analyzed in terms of spontaneous pattern formation. It is shown how the ring bifurcates from a synchronous state to a non-phase-locked state whose spike trains are characterized by quasiperiodic variations of the inter-spike intervals (ISIs) on closed invariant circles. The separation of these invariant circles in phase space results in a localized peak of activity as measured by the time-averaged firing rate of the neurons. This generates a sharp orientation tuning curve that can lock to a slowly rotating, weakly tuned external stimulus. For fast synapses, breakup of the quasiperiodic orbits occurs leading to high spike time variability suggestive of chaos.

  11. Extracting 3D parametric curves from 2D images of helical objects.

    OpenAIRE

    Willcocks, Chris; Jackson, Philip T.G.; Nelson, Carl J.; Obara, Boguslaw

    2016-01-01

    Helical objects occur in medicine, biology, cosmetics, nanotechnology, and engineering. Extracting a 3D parametric curve from a 2D image of a helical object has many practical applications, in particular being able to extract metrics such as tortuosity, frequency, and pitch. We present a method that is able to straighten the image object and derive a robust 3D helical curve from peaks in the object boundary. The algorithm has a small number of stable parameters that require little tuning, and...

  12. GENIUS-TF: a test facility for the GENIUS project

    OpenAIRE

    Baudis, L.; Dietz, A.; Heusser, G.; Majorovits, B.; Strecker, H.; Klapdor--Kleingrothaus, H. V.

    2000-01-01

    GENIUS is a proposal for a large scale detector of rare events. As a first step of the experiment, a small test version, the GENIUS test facility, will be build up at the Laboratorio Nazionale del Gran Sasso (LNGS). With about 40 kg of natural Ge detectors operated in liquid nitrogen, GENIUS-TF could exclude (or directly confirm) the DAMA annual modulation signature within about two years of measurement.

  13. Impact of maximum TF magnetic field on performance and cost of an advanced physics tokamak

    International Nuclear Information System (INIS)

    Reid, R.L.

    1983-01-01

    Parametric studies were conducted using the Fusion Engineering Design Center (FEDC) Tokamak Systems Code to investigate the impact of variation in the maximum value of the field at the toroidal field (TF) coils on the performance and cost of a low q/sub psi/, quasi-steady-state tokamak. Marginal ignition, inductive current startup plus 100 s of inductive burn, and a constant value of epsilon (inverse aspect ratio) times beta poloidal were global conditions imposed on this study. A maximum TF field of approximately 10 T was found to be appropriate for this device

  14. Theoretical model and optimization of a novel temperature sensor based on quartz tuning fork resonators

    International Nuclear Information System (INIS)

    Xu Jun; You Bo; Li Xin; Cui Juan

    2007-01-01

    To accurately measure temperatures, a novel temperature sensor based on a quartz tuning fork resonator has been designed. The principle of the quartz tuning fork temperature sensor is that the resonant frequency of the quartz resonator changes with the variation in temperature. This type of tuning fork resonator has been designed with a new doubly rotated cut work at flexural vibration mode as temperature sensor. The characteristics of the temperature sensor were evaluated and the results sufficiently met the target of development for temperature sensor. The theoretical model for temperature sensing has been developed and built. The sensor structure was analysed by finite element method (FEM) and optimized, including tuning fork geometry, tine electrode pattern and the sensor's elements size. The performance curve of output versus measured temperature is given. The results from theoretical analysis and experiments indicate that the sensor's sensitivity can reach 60 ppm 0 C -1 with the measured temperature range varying from 0 to 100 0 C

  15. Comparison of tuning methods for design of PID controller as an A VR

    International Nuclear Information System (INIS)

    Sheikh, S.A.; Ahmed, I.; Unar, M.A.

    2009-01-01

    The primary means of generator reactive power control is the generator-excitation Control, using Automatic Voltage Regulator (A VR). The role of A VR is to hold the terminal voltage magnitude of Synchronous generator at a specified level. This paper presents the design of a proportional integral-derivative (PID) controller as an A VR. The PID controller has been tuned by various tuning methods. From all methods, PID parameters are computed through various techniques i.e. Process-reaction curve, Closed-loop system, open-loop system gain margin and phase-margin specifications. From these methods, it has been found that Zhaung- Atherton method and Ho, Hang and Cao method are much superior to the conventional Ziegler-Nichols rules. The performance of the controller has been evaluated through Simulation Studies in MATLAB environment. It has been demonstrated that the PID controller, tuned with the said methods, yields highly satisfactory closed-loop performance. (author)

  16. Analysis of NSTX TF Joint Voltage Measurements

    International Nuclear Information System (INIS)

    Woolley R

    2005-01-01

    This report presents findings of analyses of recorded current and voltage data associated with 72 electrical joints operating at high current and high mechanical stress. The analysis goal was to characterize the mechanical behavior of each joint and thus evaluate its mechanical supports. The joints are part of the toroidal field (TF) magnet system of the National Spherical Torus Experiment (NSTX) pulsed plasma device operating at the Princeton Plasma Physics Laboratory (PPPL). Since there is not sufficient space near the joints for much traditional mechanical instrumentation, small voltage probes were installed on each joint and their voltage monitoring waveforms have been recorded on sampling digitizers during each NSTX ''shot''

  17. Tune-Based Halo Diagnostics

    International Nuclear Information System (INIS)

    Cameron, Peter

    2003-01-01

    Tune-based halo diagnostics can be divided into two categories -- diagnostics for halo prevention, and diagnostics for halo measurement. Diagnostics for halo prevention are standard fare in accumulators, synchrotrons, and storage rings, and again can be divided into two categories -- diagnostics to measure the tune distribution (primarily to avoid resonances), and diagnostics to identify instabilities (which will not be discussed here). These diagnostic systems include kicked (coherent) tune measurement, phase-locked loop (PLL) tune measurement, Schottky tune measurement, beam transfer function (BTF) measurements, and measurement of transverse quadrupole mode envelope oscillations. We refer briefly to tune diagnostics used at RHIC and intended for the SNS, and then present experimental results. Tune-based diagnostics for halo measurement (as opposed to prevention) are considerably more difficult. We present one brief example of tune-based halo measurement

  18. Non Nuclear Testing of Reactor Systems In The Early Flight Fission Test Facilities (EFF-TF)

    International Nuclear Information System (INIS)

    Van Dyke, Melissa; Martin, James

    2004-01-01

    The Early Flight Fission-Test Facility (EFF-TF) can assist in the design and development of systems through highly effective non-nuclear testing of nuclear systems when technical issues associated with near-term space fission systems are 'non-nuclear' in nature (e.g. system's nuclear operations are understood). For many systems, thermal simulators can be used to closely mimic fission heat deposition. Axial power profile, radial power profile, and fuel pin thermal conductivity can be matched. In addition to component and subsystem testing, operational and lifetime issues associated with the steady state and transient performance of the integrated reactor module can be investigated. Instrumentation at the EFF-TF allows accurate measurement of temperature, pressure, strain, and bulk core deformation (useful for accurately simulating nuclear behavior). Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE laboratories, industry, universities, and other Nasa centers. This paper describes the current efforts for the latter portion of 2003 and beginning of 2004. (authors)

  19. BOREAS TF-8 NSA-OJP Tower Flux, Meteorological, and Soil Temperature Data

    Science.gov (United States)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Moore, Kathleen E.; Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team collected energy, CO2, and water vapor flux data at the BOREAS NSA-OJP site during the growing season of 1994 and most of the year for 1996. The data are available in tabular ASCII files.

  20. The value of Ret-Hb and sTfR in the diagnosis of iron depletion in healthy, young children

    NARCIS (Netherlands)

    Uijterschout, L.; Domellöf, M.; Vloemans, J.; Vos, R.; Hudig, C.; Bubbers, S.; Verbruggen, S.; Veldhorst, M.; de Leeuw, T.; Teunisse, P. P.; van Goudoever, J. B.; Brus, F.

    2014-01-01

    Reticulocyte hemoglobin (Ret-Hb) content and soluble transferrin receptor (sTfR) are described as promising biomarkers in the analysis of iron status. However, the value of Ret-Hb and sTfR in the early detection of iron depletion, as frequently observed in children in high-income countries, is

  1. Fine-tuning with brane-localized flux in 6D supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Niedermann, Florian; Schneider, Robert [Arnold Sommerfeld Center for Theoretical Physics, Ludwig-Maximilians-Universität,Theresienstraße 37, 80333 Munich (Germany); Excellence Cluster Universe,Boltzmannstraße 2, 85748 Garching (Germany)

    2016-02-03

    There are claims in the literature that the cosmological constant problem could be solved in a braneworld model with two large (micron-sized) supersymmetric extra dimensions. The mechanism relies on two basic ingredients: first, the cosmological constant only curves the compact bulk geometry into a rugby shape while the 4D curvature stays flat. Second, a brane-localized flux term is introduced in order to circumvent Weinberg’s fine-tuning argument, which otherwise enters here through a backdoor via the flux quantization condition. In this paper, we show that the latter mechanism does not work in the way it was designed: the only localized flux coupling that guarantees a flat on-brane geometry is one which preserves the scale invariance of the bulk theory. Consequently, Weinberg’s argument applies, making a fine-tuning necessary again. The only remaining window of opportunity lies within scale invariance breaking brane couplings, for which the tuning could be avoided. Whether the corresponding 4D curvature could be kept under control and in agreement with the observed value will be answered in our companion paper http://arxiv.org/abs/1512.03800.

  2. Fine-tuning with brane-localized flux in 6D supergravity

    International Nuclear Information System (INIS)

    Niedermann, Florian; Schneider, Robert

    2016-01-01

    There are claims in the literature that the cosmological constant problem could be solved in a braneworld model with two large (micron-sized) supersymmetric extra dimensions. The mechanism relies on two basic ingredients: first, the cosmological constant only curves the compact bulk geometry into a rugby shape while the 4D curvature stays flat. Second, a brane-localized flux term is introduced in order to circumvent Weinberg’s fine-tuning argument, which otherwise enters here through a backdoor via the flux quantization condition. In this paper, we show that the latter mechanism does not work in the way it was designed: the only localized flux coupling that guarantees a flat on-brane geometry is one which preserves the scale invariance of the bulk theory. Consequently, Weinberg’s argument applies, making a fine-tuning necessary again. The only remaining window of opportunity lies within scale invariance breaking brane couplings, for which the tuning could be avoided. Whether the corresponding 4D curvature could be kept under control and in agreement with the observed value will be answered in our companion paper http://arxiv.org/abs/1512.03800.

  3. Test facility for PLT TF coils

    International Nuclear Information System (INIS)

    Hearney, J.; File, J.; Dreskin, S.

    1975-01-01

    Past experience with the model C stellerator and other toroidal field devices indicates that mechanical and electrical tests of a toroidal field coil prior to maximum field operation of the device is prudent and desirable. This paper describes a test program for the PLT-TF coils. The test stand consists of one test coil, two background coils and a steel supporting structure. The three coil configuration produces a 67.5 kG field at the inner conductor (38 kG at the bore center) and simulates a 1/R field distribution in the bore of the test coil. The resolution of the field force system and resultant stresses within the test structure are discussed. A test procedure is described which maximizes the information obtained from a 100,000 pulse program

  4. Quantitative comparison of MiTF, Melan-A, HMB-45 and Mel-5 in solar lentigines and melanoma in situ.

    Science.gov (United States)

    Kim, Jinah; Taube, Janis M; McCalmont, Timothy H; Glusac, Earl J

    2011-10-01

    It is often challenging to reliably assess the number of lesional melanocytes in intraepidermal melanocytic proliferations involving sun-damaged skin. Therefore, dermatopathologists routinely use immunostains to help differentiate melanocytes from surrounding keratinocytes. Forty-three cases of solar lentigo or melanoma in situ (of the lentigo maligna type) were retrospectively chosen (20 melanomas in situ and 23 solar lentigo). Microphthalmia transcription factor (MiTF), HMB-45, Melan-A and Mel-5 immunostains were performed with an Azure blue counterstain, and the mean melanocyte counts were calculated within a 1-mm segment of epidermis. In solar lentigines, the mean melanocyte counts were 27 (MiTF), 23 (HMB-45 and Mel-5) and 41 (Melan-A), as compared to hematoxylin and eosin (H&E) (25). In melanoma in situ, the mean melanocyte counts were 112 (MiTF), 149 (Melan-A), 111 (HMB-45) and 80 (Mel-5), as compared to H&E (109). These results show that Melan-A significantly overestimates the density of melanocytes within dermatoheliotic skin. Compared to other tested stains, nuclear staining MiTF allowed greater distinction of melanocytes from keratinocytes with melanized cytoplasm. These findings indicate that MiTF is a superior marker for quantification of melanocytes in the evaluation of subtle intraepidermal melanocytic proliferations and in the differential diagnosis of solar lentigo. Copyright © 2011 John Wiley & Sons A/S.

  5. Short initial length quench on CICC of ITER TF coils

    Energy Technology Data Exchange (ETDEWEB)

    Nicollet, S.; Ciazynski, D.; Duchateau, J.-L.; Lacroix, B. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Bessette, D.; Rodriguez-Mateos, F. [ITER Organization, Route de Vinon sur Verdon, 13115 Saint Paul Lez Durance (France); Coatanea-Gouachet, M. [ELC Engineering, 350 chemin du Verladet, F-13290 Les Milles (France); Gauthier, F. [Soditech Ingenierie, 4 bis allée des Gabians, ZI La Frayère, 06150 Cannes (France)

    2014-01-29

    Previous quench studies performed for the International Thermonuclear Experimental Reactor (ITER) Toroidal Field (TF) Coils have led to identify two extreme families of quench: first 'severe' quenches over long initial lengths in high magnetic field, and second smooth quenches over short initial lengths in low field region. Detailed analyses and results on smooth quench propagation and detectability on one TF Cable In Conduit Conductor (CICC) with a lower propagation velocity are presented here. The influence of the initial quench energy is shown and results of computations with either a Fast Discharge (FD) of the magnet or without (failure of the voltage quench detection system) are reported. The influence of the central spiral of the conductor on the propagation velocity is also detailed. In the cases of a regularly triggered FD, the hot spot temperature criterion of 150 K (with helium and jacket) is fulfilled for an initial quench length of 1 m, whereas this criterion is exceed (Tmax ≈ 200 K) for an extremely short length of 5 cm. These analyses were carried out using both the Supermagnet(trade mark, serif) and Venecia codes and the comparisons of the results are also discussed.

  6. Short initial length quench on CICC of ITER TF coils

    International Nuclear Information System (INIS)

    Nicollet, S.; Ciazynski, D.; Duchateau, J.-L.; Lacroix, B.; Bessette, D.; Rodriguez-Mateos, F.; Coatanea-Gouachet, M.; Gauthier, F.

    2014-01-01

    Previous quench studies performed for the International Thermonuclear Experimental Reactor (ITER) Toroidal Field (TF) Coils have led to identify two extreme families of quench: first 'severe' quenches over long initial lengths in high magnetic field, and second smooth quenches over short initial lengths in low field region. Detailed analyses and results on smooth quench propagation and detectability on one TF Cable In Conduit Conductor (CICC) with a lower propagation velocity are presented here. The influence of the initial quench energy is shown and results of computations with either a Fast Discharge (FD) of the magnet or without (failure of the voltage quench detection system) are reported. The influence of the central spiral of the conductor on the propagation velocity is also detailed. In the cases of a regularly triggered FD, the hot spot temperature criterion of 150 K (with helium and jacket) is fulfilled for an initial quench length of 1 m, whereas this criterion is exceed (Tmax ≈ 200 K) for an extremely short length of 5 cm. These analyses were carried out using both the Supermagnet(trade mark, serif) and Venecia codes and the comparisons of the results are also discussed

  7. Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.

    Science.gov (United States)

    Xie, Yuran; Kim, Na Hyung; Nadithe, Venkatareddy; Schalk, Dana; Thakur, Archana; Kılıç, Ayşe; Lum, Lawrence G; Bassett, David J P; Merkel, Olivia M

    2016-05-10

    Asthma is a worldwide health problem. Activated T cells (ATCs) in the lung, particularly T helper 2 cells (Th2), are strongly associated with inducing airway inflammatory responses and chemoattraction of inflammatory cells in asthma. Small interfering RNA (siRNA) as a promising anti-sense molecule can specifically silence inflammation related genes in ATCs, however, lack of safe and efficient siRNA delivery systems limits the application of siRNA as a therapeutic molecule in asthma. Here, we designed a novel pulmonary delivery system of siRNA, transferrin-polyethylenimine (Tf-PEI), to selectively deliver siRNA to ATCs in the lung. Tf-PEI polyplexes demonstrated optimal physicochemical properties such as size, distribution, zeta-potential, and siRNA condensation efficiency. Moreover, in vitro studies showed significantly enhanced cellular uptake and gene knockdown mediated by Tf-PEI polyplexes in human primary ATCs. Biodistribution of polyplexes in a murine asthmatic model confirmed that Tf-PEI polyplexes can efficiently and selectively deliver siRNA to ATCs. In conclusion, the present work proves the feasibility to target ATCs in asthma via Tf receptor. This strategy could potentially be used to design an efficient siRNA delivery system for asthma therapy. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Treatment processes and demographic variables as predictors of dropout from trauma-focused cognitive behavioral therapy (TF-CBT) for youth.

    Science.gov (United States)

    Yasinski, Carly; Hayes, Adele M; Alpert, Elizabeth; McCauley, Thomas; Ready, C Beth; Webb, Charles; Deblinger, Esther

    2018-05-22

    Premature dropout is a significant concern in trauma-focused psychotherapy for youth. Previous studies have primarily examined pre-treatment demographic and symptom-related predictors of dropout, but few consistent findings have been reported. The current study examined demographic, symptom, and in-session process variables as predictors of dropout from Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for youth. Participants were a diverse sample of Medicaid-eligible youth (ages 7-17; n = 108) and their nonoffending caregivers (n = 86), who received TF-CBT through an effectiveness study in a community setting. In-session process variables were coded from audio-recorded sessions, and these and pre-treatment demographic variables and symptom levels were examined as predictors of dropout prior to receiving an adequate dose of TF-CBT (parents or relatives. No other demographic or symptom-related factors predicted dropout. These findings highlight the importance of addressing avoidance and therapeutic relationship difficulties in early sessions of TF-CBT to help reduce dropout, and they have implications for improving efforts to disseminate evidence-based trauma-focused treatments. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. The twenty-four/four hour ratio (T/F ratio) of Tc-99m MDP uptake in patients with bone metastases and degenerative changes

    International Nuclear Information System (INIS)

    Israel, O.; Kleinhaus, U.; Keren, R.; Frankel, A.; Front, D.

    1984-01-01

    Normal and metastatic bone differ in their histological structure. Normal bone is mainly lamellar while metastatic bone formation is made in a large part out of new woven bone. The woven bone has a much larger surface area than the more stable lamellar bone and it is lined with metabolically active osteoblasts. The crystalline structures in the woven bone are smaller and have a larger surface area available for absorption. Uptake of bone seeking radiopharmaceuticals continues in new woven bone longer than in the lamellar bone. Bone scintigraphy was performed in 89 patients at four hours and 24 hours using a digital camera. The lesion to non lesion (L/N) ratio was determined using the camera computer. The T/F ratio was calculated: T/F=((L/N)-24)/((L/N)-4). Three groups were investigated. In 15 patients with metastatic bone carcinoma, T/F ratio was 1.46 +- 0.4. In 47 patients with degenerative joint disease the T/F ratio was 1.05 +- 0.06. In 27 patients with treated metastatic bone carcinoma the T/F ratio was 1.12 +- 0.13. The T/F ratio is significantly (p<0.001) different in patients with metastases compared to patients with benign degenerative disease. Chemotherapeutic and hormonal treatment cause significant (p<0.001) reduction in the T/F ratio. The T/F ratio may have a potential in differentiating degenerative from neoplastic diseases and in the evaluation of patients with bone metastases undergoing treatment

  10. Preliminary power supply design for the TF coil system of CIT

    International Nuclear Information System (INIS)

    Neumeyer, C.; Bronner, G.; Huttar, D.

    1989-01-01

    Initial operation of the Compact Ignition Tokamak (CIT) is planned with a Toroidal Field (TF) of 8 Tesla and a flat top duration of 5 seconds. Ultimately, operation will be extended beyond 8 Tesla. The power supply to be used for the initial phase of operation has been modeled using the parameters of the thyristor rectifier power supplies which are now in service for the Tokamak Fusion Test Reactor (TFTR). A subset of these existing units, or perhaps new units with similar ratings, are envisioned to be connected to the existing 138kV transmission line serving PPPL so as to take advantage of this power source for CIT. For the extended operation phase the equipment used for the initial phase of TF operation will be augmented with new equipment to permit operation up to 11 Tesla. This paper describes the preliminary design for the 8 Tesla power supply and presents results from simulation studies. In addition, issues concerning transient behavior and fault modes are discussed. 4 refs., 12 figs

  11. Detailed design studies at CEA for JT-60SA TF coils

    International Nuclear Information System (INIS)

    Decool, P.; Marechal, J.L.; Portafaix, C.; Lacroix, B.; Gros, G.; Verger, J.M.

    2011-01-01

    Following a first conceptual design activity in which the general design of the JT-60SA TF system was defined and frozen in agreement with all the participants in the project (CEA, ENEA, F4E), a second phase had to be launched to deal with the detailed design. In this paper, we present the work performed at CEA on the TF coil design during this second phase. Part of this work, concerns the determination of conductor hydraulic performances during operation as well as in factory. The thermohydraulic of the conductor was also assessed to confirm the need of helium inlets and a specific design was developed and qualified to be compatible with the available hydraulic performance of the cryoplant. The mechanical behavior is still to be assessed and qualified. Last but not least, the inner electrical joints of the coil have been modified with respect to the original twin-box design developed by CEA for the ITER coils in order to simplify the fabrication process. A dedicated qualification program for their manufacture is ongoing.

  12. AC loss, interstrand resistance and mechanical properties of prototype EU DEMO TF conductors up to 30 000 load cycles

    Science.gov (United States)

    Yagotintsev, K.; Nijhuis, A.

    2018-07-01

    Two prototype Nb3Sn cable-in-conduit conductors conductors were designed and manufactured for the toroidal field (TF) magnet system of the envisaged European DEMO fusion reactor. The AC loss, contact resistance and mechanical properties of two sample conductors were tested in the Twente Cryogenic Cable Press under cyclic load up to 30 000 cycles. Though both conductors were designed to operate at 82 kA in a background magnetic field of 13.6 T, they reflect different approaches with respect to the magnet winding pack assembly. The first approach is based on react and wind technology while the second is the more common wind and react technology. Each conductor was tested first for AC loss in virgin condition without handling. The impact of Lorentz load during magnet operation was simulated using the cable press. In the press each conductor specimen was subjected to transverse cyclic load up to 30 000 cycles in liquid helium bath at 4.2 K. Here a summary of results for AC loss, contact resistance, conductor deformation, mechanical heat production and conductor stiffness evolution during cycling of the load is presented. Both conductors showed similar mechanical behaviour but quite different AC loss. In comparison with previously tested ITER TF conductors, both DEMO TF conductors possess very low contact resistance resulting in high coupling loss. At the same time, load cycling has limited impact on properties of DEMO TF conductors in comparison with ITER TF conductors.

  13. Extracting 3D Parametric Curves from 2D Images of Helical Objects.

    Science.gov (United States)

    Willcocks, Chris G; Jackson, Philip T G; Nelson, Carl J; Obara, Boguslaw

    2017-09-01

    Helical objects occur in medicine, biology, cosmetics, nanotechnology, and engineering. Extracting a 3D parametric curve from a 2D image of a helical object has many practical applications, in particular being able to extract metrics such as tortuosity, frequency, and pitch. We present a method that is able to straighten the image object and derive a robust 3D helical curve from peaks in the object boundary. The algorithm has a small number of stable parameters that require little tuning, and the curve is validated against both synthetic and real-world data. The results show that the extracted 3D curve comes within close Hausdorff distance to the ground truth, and has near identical tortuosity for helical objects with a circular profile. Parameter insensitivity and robustness against high levels of image noise are demonstrated thoroughly and quantitatively.

  14. Full scale trials for qualification of the manufacture of the ITER TF coils in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Matsui, Kunihiro, E-mail: matsui.kunihiro@jaea.go.jp; Hemmi, Tsutomu; Kajitani, Hideki; Yamane, Minoru; Mizutani, Takumi; Nakano, Toshihide; Takano, Katsutoshi; Ando, Shinji; Koizumi, Norikiyo

    2016-11-01

    Highlights: • High accuracy conductor winding of 0.1% was achieved in TF coil fabrication. • Conductor elongation due to heat treatment satisfied with the expected value of 0.06% ± 0.02%. • Commissioning of a transfer tooling without adding strain to conductor was completed. • Commissioning of a conductor insulation and CP welding was successfully completed. - Abstract: JAEA performed full-scale trials to qualify and optimize manufacturing procedure of TF coil fabrication prior to series production. In the full-scale trials, conductor winding, heat treatment, conductor transfer, conductor insulation and cover plate (CP) welding trials were performed to resolve some technical issues and to demonstrate the fabrication procedure. The followings are major achievement. (1) High accuracy conductor winding of 0.01%, (2) the evaluation of 0.06% conductor elongation due to heat treatment, (3) conductor transfer in a radial plate (RP) groove with addition strain under 0.1%, (4) conductor insulation without breakage of the insulation tape and (5) flatness of 2 mm of the double pancake (DP) by CP welding. Then JAEA started the 1st TF coil fabrication from March 2014, and has already completed ten conductor windings and heat treatment of nine windings.

  15. PERI auto-tuning

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, D H; Williams, S [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Chame, J; Chen, C; Hall, M [USC/ISI, Marina del Rey, CA 90292 (United States); Dongarra, J; Moore, S; Seymour, K; You, H [University of Tennessee, Knoxville, TN 37996 (United States); Hollingsworth, J K; Tiwari, A [University of Maryland, College Park, MD 20742 (United States); Hovland, P; Shin, J [Argonne National Laboratory, Argonne, IL 60439 (United States)], E-mail: mhall@isi.edu

    2008-07-15

    The enormous and growing complexity of today's high-end systems has increased the already significant challenges of obtaining high performance on equally complex scientific applications. Application scientists are faced with a daunting challenge in tuning their codes to exploit performance-enhancing architectural features. The Performance Engineering Research Institute (PERI) is working toward the goal of automating portions of the performance tuning process. This paper describes PERI's overall strategy for auto-tuning tools and recent progress in both building auto-tuning tools and demonstrating their success on kernels, some taken from large-scale applications.

  16. GENIUS and the Genius TF: A New Observatory for WIMP Dark Matter and Neutrinoless Double Beta Decay

    OpenAIRE

    Klapdor-Kleingrothaus, H. V.; Majorovits, B.

    2001-01-01

    The GENIUS proposal is described and some of it's physics potential is outlined. Also in the light of the contradictive results from the DAMA and CDMS experiments the Genius TF, a new experimental setup is proposed. The Genius TF could probe the DAMA evidence region using the WIMP nucleus recoil signal and WIMP annual modulation signature simultaneously. Besides that it can prove the long term feasibility of the detector technique to be implemented into the GENIUS setup and will in this sense...

  17. Practical tuning for Oracle

    International Nuclear Information System (INIS)

    Kwon, Sun Yong

    2005-02-01

    This book deals with tuning for oracle application, which consists of twenty two chapters. These are the contents of this book : what is tuning?, procedure of tuning, collection of performance data using stats pack, collection of performance data in real time, disk IO dispersion, architecture on Index, partition and IOT, optimization of cluster Factor, optimizer, analysis on plan of operation, selection of Index, tuning of Index, parallel processing architecture, DML, analytic function join method, join type, analysis of application, Lock architecture, SGA architecture and wait event and segment tuning.

  18. BOREAS TF-3 NSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    Science.gov (United States)

    Wofsy, Steven; Sutton, Doug; Goulden, Mike; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-3) team collected tower flux, surface meteorological, and soil temperature data at the BOREAS Northern Study Area-Old Black Spruce (NSA-OBS) site continuously from the March 1994 through October 1996. The data are available in tabular ASCII files.

  19. CardioTF, a database of deconstructing transcriptional circuits in the heart system.

    Science.gov (United States)

    Zhen, Yisong

    2016-01-01

    Information on cardiovascular gene transcription is fragmented and far behind the present requirements of the systems biology field. To create a comprehensive source of data for cardiovascular gene regulation and to facilitate a deeper understanding of genomic data, the CardioTF database was constructed. The purpose of this database is to collate information on cardiovascular transcription factors (TFs), position weight matrices (PWMs), and enhancer sequences discovered using the ChIP-seq method. The Naïve-Bayes algorithm was used to classify literature and identify all PubMed abstracts on cardiovascular development. The natural language learning tool GNAT was then used to identify corresponding gene names embedded within these abstracts. Local Perl scripts were used to integrate and dump data from public databases into the MariaDB management system (MySQL). In-house R scripts were written to analyze and visualize the results. Known cardiovascular TFs from humans and human homologs from fly, Ciona, zebrafish, frog, chicken, and mouse were identified and deposited in the database. PWMs from Jaspar, hPDI, and UniPROBE databases were deposited in the database and can be retrieved using their corresponding TF names. Gene enhancer regions from various sources of ChIP-seq data were deposited into the database and were able to be visualized by graphical output. Besides biocuration, mouse homologs of the 81 core cardiac TFs were selected using a Naïve-Bayes approach and then by intersecting four independent data sources: RNA profiling, expert annotation, PubMed abstracts and phenotype. The CardioTF database can be used as a portal to construct transcriptional network of cardiac development. Database URL: http://www.cardiosignal.org/database/cardiotf.html.

  20. Preceding weak noise sharpens the frequency tuning and elevates the response threshold of the mouse inferior collicular neurons through GABAergic inhibition.

    Science.gov (United States)

    Wang, Xin; Jen, Philip H-S; Wu, Fei-Jian; Chen, Qi-Cai

    2007-09-05

    In acoustic communication, animals must extract biologically relevant signals that are embedded in noisy environment. The present study examines how weak noise may affect the auditory sensitivity of neurons in the central nucleus of the mouse inferior colliculus (IC) which receives convergent excitatory and inhibitory inputs from both lower and higher auditory centers. Specifically, we studied the frequency sensitivity and minimum threshold of IC neurons using a pure tone probe and a weak white noise masker under forward masking paradigm. For most IC neurons, probe-elicited response was decreased by a weak white noise that was presented at a specific gap (i.e. time window). When presented within this time window, weak noise masking sharpened the frequency tuning curve and increased the minimum threshold of IC neurons. The degree of weak noise masking of these two measurements increased with noise duration. Sharpening of the frequency tuning curve and increasing of the minimum threshold of IC neurons during weak noise masking were mostly mediated through GABAergic inhibition. In addition, sharpening of frequency tuning curve by the weak noise masker was more effective at the high than at low frequency limb. These data indicate that in the real world the ambient noise may improve frequency sensitivity of IC neurons through GABAergic inhibition while inevitably decrease the frequency response range and sensitivity of IC neurons.

  1. On the frontier of boiling curve and beyond design of its origin

    International Nuclear Information System (INIS)

    Stosic, Z.V.

    2005-01-01

    An advanced approach of Extended Design of the Boiling Curve beyond its origin is proposed. It is developed from the fact that both CHF (Critical Heat Flux) and rewetting affect the Boiling Curve on the heating surface through two simultaneous processes taking place on both sides of the heating surface. The first is two-phase flow thermal-hydraulics with resultant heat transferred from the heating surface to the coolant. The second one is the heat conduction through material itself, allied with the balance of generated and accumulated energy. Both of these processes are triggered by the change in HTC (Heat Transfer Coefficient) on the heating surface, which accordingly influences the Boiling Curve. Depending on direction of the Transition - from nucleate to film boiling or vice versa - these processes act differently and direct the Boiling Curve to diverse paths. The proposed physically based concept recognises this fact and introduces HTC as the triggering parameter with instant effect. It is implemented in the subchannel code COBRA 3-CP providing stable rewetting which has been deficient in COBRA since its origin. Results of validation and obtained agreements with transient measured data prove legality of the advanced concept of Boiling Curve. This approach is being used for transient analyses of PWR (Pressurised Water Reactor) gaining benefits from properly predicting the rewetting. The method is well-qualified to be applied also in other thermal-hydraulic codes like COBRA/TRAC, COBRA-TF, TRAC and/or RELAP, where the classical steady-state and poolboiling approach has been originally implemented. (author)

  2. Discrete mKdV and discrete sine-Gordon flows on discrete space curves

    International Nuclear Information System (INIS)

    Inoguchi, Jun-ichi; Kajiwara, Kenji; Matsuura, Nozomu; Ohta, Yasuhiro

    2014-01-01

    In this paper, we consider the discrete deformation of the discrete space curves with constant torsion described by the discrete mKdV or the discrete sine-Gordon equations, and show that it is formulated as the torsion-preserving equidistant deformation on the osculating plane which satisfies the isoperimetric condition. The curve is reconstructed from the deformation data by using the Sym–Tafel formula. The isoperimetric equidistant deformation of the space curves does not preserve the torsion in general. However, it is possible to construct the torsion-preserving deformation by tuning the deformation parameters. Further, it is also possible to make an arbitrary choice of the deformation described by the discrete mKdV equation or by the discrete sine-Gordon equation at each step. We finally show that the discrete deformation of discrete space curves yields the discrete K-surfaces. (paper)

  3. SQL Tuning

    CERN Document Server

    Tow, Dan

    2003-01-01

    A poorly performing database application not only costs users time, but also has an impact on other applications running on the same computer or the same network. SQL Tuning provides an essential next step for SQL developers and database administrators who want to extend their SQL tuning expertise and get the most from their database applications.There are two basic issues to focus on when tuning SQL: how to find and interpret the execution plan of an SQL statement and how to change SQL to get a specific alternate execution plan. SQL Tuning provides answers to these questions and addresses a third issue that's even more important: how to find the optimal execution plan for the query to use.Author Dan Tow outlines a timesaving method he's developed for finding the optimum execution plan--rapidly and systematically--regardless of the complexity of the SQL or the database platform being used. You'll learn how to understand and control SQL execution plans and how to diagram SQL queries to deduce the best executio...

  4. A new meshless approach to map electromagnetic loads for FEM analysis on DEMO TF coil system

    International Nuclear Information System (INIS)

    Biancolini, Marco Evangelos; Brutti, Carlo; Giorgetti, Francesco; Muzzi, Luigi; Turtù, Simonetta; Anemona, Alessandro

    2015-01-01

    Graphical abstract: - Highlights: • Generation and mapping of magnetic load on DEMO using radial basis function. • Good agreement between RBF interpolation and EM TOSCA computations. • Resultant forces are stable with respect to the target mesh used. • Stress results are robust and accurate even if a coarse cloud is used for RBF interpolation. - Abstract: Demonstration fusion reactors (DEMO) are being envisaged to be able to produce commercial electrical power. The design of the DEMO magnets and of the constituting conductors is a crucial issue in the overall engineering design of such a large fusion machine. In the frame of the EU roadmap of the so-called fast track approach, mechanical studies of preliminary DEMO toroidal field (TF) coil system conceptual designs are being enforced. The magnetic field load acting on the DEMO TF coil conductor has to be evaluated as input in the FEM model mesh, in order to evaluate the stresses on the mechanical structure. To gain flexibility, a novel approach based on the meshless method of radial basis functions (RBF) has been implemented. The present paper describes this original and flexible approach for the generation and mapping of magnetic load on DEMO TF coil system.

  5. Stability of [MeBu3N][Tf2N] under gamma irradiation

    International Nuclear Information System (INIS)

    Bosse, Emilie; Berthon, Laurence; Zorz, Nicole; Monget, Julie; Berthon, Claude; Bisel, Isabelle; Legand, Solene; Moisy, Philippe

    2008-01-01

    The stability of the ionic liquid [MeBu 3 N][Tf 2 N], dry or after contact with water (where [MeBu 3 N] + is the methyl-tributyl-ammonium cation and [Tf 2 N] - is the bistriflimide anion), was studied under 137 Cs gamma irradiation in argon and in air. In a quantitative study with an absorbed dose of 2 MGy this ionic liquid was highly stable regardless of the radiolysis conditions. The radiolytic disappearance yields determined by ESI-MS were -0.38 and -0.25 μmol*J -1 for the cation and anion, respectively. ESI-MS, NMR, and liquid chromatography coupled with ESI-MS identified a large number of degradation products in very small quantities for the same dose. The cation radicals were formed by the loss of a Bu . group, the Me . group, or two H . atoms to form a double bond with the butyl chain. Radiolysis of the anion produced mainly F . and CF 3 . radicals. The anion radicals recombined with the cation to form a wide range of secondary degradation products regardless of the radiolysis conditions. (authors)

  6. Diphenylphosphino Styrene-Containing Homopolymers: Influence of Alkylation and Mobile Anions on Physical Properties.

    Science.gov (United States)

    Jangu, Chainika; Schultz, Alison R; Wall, Candace E; Esker, Alan R; Long, Timothy E

    2016-07-01

    Conventional free radical polymerization and post-alkylation of 4-diphenylphosphino styrene (DPPS) generate a new class of high-molecular-weight phosphonium-containing homopolymers with tunable thermal, viscoelastic, and wetting properties. Post-alkylation and subsequent anion exchange provide an effective method for tuning Tg values and thermal stability as a function of alkyl chain length and counteranion selection (X(-) , BF4 (-) , TfO(-) , and Tf2 N(-) ). Rheological characterization facilitates the generation of time-temperature-superposition (TTS) pseudomaster curves and subsequent analysis of frequency sweeps at various temperatures reveals two relaxation modes corresponding to long-range segmental motion and the onset of viscous flow. Contact angle measurements reveal the influence of counteranion selection on wetting properties, revealing increased contact angles for homopolymers containing nucleophilic counteranions. These investigations provide fundamental insight into phosphonium-containing polymers, aiming to guide future research and applications involving electro-active polymeric devices. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Fungal Endophytes as a Metabolic Fine-Tuning Regulator for Wine Grape.

    Directory of Open Access Journals (Sweden)

    Ming-Zhi Yang

    Full Text Available Endophytes proved to exert multiple effects on host plants, including growth promotion, stress resistance. However, whether endophytes have a role in metabolites shaping of grape has not been fully understood. Eight endophytic fungal strains which originally isolated from grapevines were re-inoculated to field-grown grapevines in this study, and their effects on both leaves and berries of grapevines at maturity stage were assessed, with special focused on secondary metabolites and antioxidant activities. High-density inoculation of all these endophytic fungal strains modified the physio-chemical status of grapevine to different degrees. Fungal inoculations promoted the content of reducing sugar (RS, total flavonoids (TF, total phenols (TPh, trans-resveratrol (Res and activities of phenylalanine ammonia-lyase (PAL, in both leaves and berries of grapevine. Inoculation of endophytic fungal strains, CXB-11 (Nigrospora sp. and CXC-13 (Fusarium sp. conferred greater promotion effects in grape metabolic re-shaping, compared to other used fungal strains. Additionally, inoculation of different strains of fungal endophytes led to establish different metabolites patterns of wine grape. The work implies the possibility of using endophytic fungi as fine-tuning regulator to shape the quality and character of wine grape.

  8. Design considerations for the TF center conductor post for the Ignition Spherical Torus (IST)

    International Nuclear Information System (INIS)

    Dalton, G.R.; Haines, J.R.

    1986-01-01

    A trade-off study has been carried out to compare the differential costs of using high-strength alloy copper versus oxygen-free, high-conductivity (OFHC) copper for the center legs of the toroidal field (TF) coils of an Ignition Spherical Torus (IST). The electrical heating, temperatures, stresses, cooling requirements, material costs, pump costs, and power to drive the TF coils and pumps are all assessed for both materials for a range of compact tokamak reactors. The alloy copper material is found to result in a more compact reactor and to allow use of current densities of up to 170 MA/m 2 versus 40 MA/m 2 for the OFHC copper. The OFHC conductor system with high current density is $24 million less expensive than more conventional copper systems with 30 MA/m 2 . The alloy copper system costs $32 million less than conventional systems. Therefore, the alloy system offers a net savings of $8 million compared to the 50% cold-worked OFHC copper system. Although the savings are a significant fraction of the center conductor post cost, they are relatively insignificant in terms of the total device cost. It is concluded that the use of alloy copper contributes very little to the economic or technical viability of the compact IST. It is recommended that a similar systematic approach be applied to evaluating coil material and current density trade-offs for other compact copper-TF-coil tokamak designs. 9 refs., 13 figs., 13 tabs

  9. iTunes music

    CERN Document Server

    Katz, Bob

    2013-01-01

    Apple's exciting new Mastered for iTunes (MFiT) initiative, introduced in early 2012, introduces new possibilities for delivering high-quality audio. For the first time, record labels and program producers are encouraged to deliver audio materials to iTunes in a high resolution format, which can produce better-sounding masters. In iTunes Music, author and world-class mastering engineer Bob Katz starts out with the basics, surveys the recent past, and brings you quickly up to the present-where the current state of digital audio is bleak. Katz explains the evolution of

  10. A Novel Demountable TF Joint Design for Low Aspect Ratio Spherical Torus Tokamaks

    International Nuclear Information System (INIS)

    Woolley, R.D.

    2009-01-01

    A novel shaped design for the radial conductors and demountable electrical joints connecting inner and outer legs of copper TF system conductors in low aspect ratio tokamaks is described and analysis results are presented. Specially shaped designs can optimize profiles of electrical current density, magnetic force, heating, and mechanical stress

  11. A Novel Demountable TF Joint Design for Low Aspect Ratio Spherical Torus Tokamaks

    International Nuclear Information System (INIS)

    Woolley, Robert D.

    2009-01-01

    A novel shaped design for the radial conductors and demountable electrical joints connecting inner and outer legs of copper TF system conductors in low aspect ratio tokamaks is described and analysis results are presented. Specially shaped designs can optimize profiles of electrical current density, magnetic force, heating, and mechanical stress.

  12. Qualification of the US Made Conductors for ITER TF Magnet System

    International Nuclear Information System (INIS)

    Martovetsky, Nicolai N.; Hatfield, Daniel R.; Miller, John R.; Bruzzone, P.; Stepanov, B.; Seber, B.

    2010-01-01

    The US Domestic Agency (USDA) is one of the six suppliers of the Toroidal Field (TF) conductor for the International Thermonuclear Experimental Reactor (ITER). In order to qualify conductors according to ITER requirements we prepared several lengths of the CICC and short samples for testing in the SULTAN facility in CRPP, Switzerland. We also fully characterized the strands that were used in these SULTAN samples. Fabrication experience and test results are presented and discussed.

  13. Java performance tuning

    CERN Document Server

    Shirazi, Jack

    2003-01-01

    Performance has been an important issue for Java developers ever since the first version hit the streets. Over the years, Java performance has improved dramatically, but tuning is essential to get the best results, especially for J2EE applications. You can never have code that runs too fast. Java Peformance Tuning, 2nd edition provides a comprehensive and indispensable guide to eliminating all types of performance problems. Using many real-life examples to work through the tuning process in detail, JPT shows how tricks such as minimizing object creation and replacing strings with arrays can

  14. Stability of [MeBu3N][Tf2N] under gamma irradiation

    International Nuclear Information System (INIS)

    Bosse, E.; Berthon, L.; Zorz, N.; Monget, J.; Berthon, C.; Bisel, I.; Legand, S.; Moisy, P.

    2008-01-01

    The stability of the ionic liquid [MeBu 3 N][Tf 2 N], dry or after contact with water (where [MeBu 3 N] + is the methyl-tributyl-ammonium cation and [Tf 2 N] - is the bistriflimide anion), was studied under 137 Cs gamma irradiation in argon and in air. In a quantitative study with an absorbed dose of 2 MGy this ionic liquid was highly stable regardless of the radiolysis conditions. The radiolytic disappearance yields determined by ESI-MS were -0.38 and -0.25 μmolJ -1 for the cation and anion, respectively. ESI-MS, NMR, and liquid chromatography coupled with ESI-MS identified a large number of degradation products in very small quantities for the same dose. The cation radicals were formed by the loss of a Bu-radical group, the Me-radical group, or two H-radical atoms to form a double bond with the butyl chain. Radiolysis of the anion produced mainly F-radical and CF 3 -radicals. The anion radicals recombined with the cation to form a wide range of secondary degradation products regardless of the radiolysis conditions. (authors)

  15. FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cells

    OpenAIRE

    Julie Bourseguin; Caroline Bonet; Emilie Renaud; Charlotte Pandiani; Marina Boncompagni; Sandy Giuliano; Patrycja Pawlikowska; Houda Karmous-Benailly; Robert Ballotti; Filippo Rosselli; Corine Bertolotto

    2016-01-01

    Proteins involved in genetic stability maintenance and safeguarding DNA replication act not only against cancer initiation but could also play a major role in sustaining cancer progression. Here, we report that the FANC pathway is highly expressed in metastatic melanoma harboring the oncogenic microphthalmia-associated transcription factor (MiTF). We show that MiTF downregulation in melanoma cells lowers the expression of several FANC genes and proteins. Moreover, we observe that, similarly t...

  16. Remote tuning of NMR probe circuits.

    Science.gov (United States)

    Kodibagkar, V D; Conradi, M S

    2000-05-01

    There are many circumstances in which the probe tuning adjustments cannot be located near the rf NMR coil. These may occur in high-temperature NMR, low-temperature NMR, and in the use of magnets with small diameter access bores. We address here circuitry for connecting a fixed-tuned probe circuit by a transmission line to a remotely located tuning network. In particular, the bandwidth over which the probe may be remotely tuned while keeping the losses in the transmission line acceptably low is considered. The results show that for all resonant circuit geometries (series, parallel, series-parallel), overcoupling of the line to the tuned circuit is key to obtaining a large tuning bandwidth. At equivalent extents of overcoupling, all resonant circuit geometries have nearly equal remote tuning bandwidths. Particularly for the case of low-loss transmission line, the tuning bandwidth can be many times the tuned circuit's bandwidth, f(o)/Q. Copyright 2000 Academic Press.

  17. BOREAS TF-8 NSA-OJP and SSA-OBS Ceilometer Data

    Science.gov (United States)

    Moore, Kathleen E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team used ceilometers to collect data on the fraction of the sky covered with clouds and the cloud height. Included with these data is the surface-based lifting condensation level, derived from temperature and humidity values acquired at the flux tower at the NSA-OJP site. Ceilo-meter data were collected at the NSA-OJP site in 1994 and at the NSA-OJP and SSA-OBS sites in 1996. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884).

  18. High-Pressure Phase Equilibria in Systems Containing CO2 and Ionic Liquid of the [Cnmim][Tf2N] Type

    OpenAIRE

    Sedláková, Z. (Zuzana); Wagner, Z. (Zdeněk)

    2012-01-01

    In this review, we present a comparison of the high-pressure phase behaviour of binary systems constituted of CO2 and ionic liquids of the [Cn(m)mim][Tf2N] type. The comparative study shows that the solubility of CO2 in ionic liquids of the [Cnmim][Tf2N] type generally increases with increasing pressure and decreasing temperature, but some peculiarities have been observed. The solubility of CO2 in ionic liquid solvents was correlated using the Soave–Redlich–Kwong equation of state. The result...

  19. TF-finder: A software package for identifying transcription factors involved in biological processes using microarray data and existing knowledge base

    Directory of Open Access Journals (Sweden)

    Cui Xiaoqi

    2010-08-01

    Full Text Available Abstract Background Identification of transcription factors (TFs involved in a biological process is the first step towards a better understanding of the underlying regulatory mechanisms. However, due to the involvement of a large number of genes and complicated interactions in a gene regulatory network (GRN, identification of the TFs involved in a biology process remains to be very challenging. In reality, the recognition of TFs for a given a biological process can be further complicated by the fact that most eukaryotic genomes encode thousands of TFs, which are organized in gene families of various sizes and in many cases with poor sequence conservation except for small conserved domains. This poses a significant challenge for identification of the exact TFs involved or ranking the importance of a set of TFs to a process of interest. Therefore, new methods for recognizing novel TFs are desperately needed. Although a plethora of methods have been developed to infer regulatory genes using microarray data, it is still rare to find the methods that use existing knowledge base in particular the validated genes known to be involved in a process to bait/guide discovery of novel TFs. Such methods can replace the sometimes-arbitrary process of selection of candidate genes for experimental validation and significantly advance our knowledge and understanding of the regulation of a process. Results We developed an automated software package called TF-finder for recognizing TFs involved in a biological process using microarray data and existing knowledge base. TF-finder contains two components, adaptive sparse canonical correlation analysis (ASCCA and enrichment test, for TF recognition. ASCCA uses positive target genes to bait TFS from gene expression data while enrichment test examines the presence of positive TFs in the outcomes from ASCCA. Using microarray data from salt and water stress experiments, we showed TF-finder is very efficient in recognizing

  20. GENIUS-TF: a test facility for the GENIUS project

    International Nuclear Information System (INIS)

    Klapdor-Kleingrothaus, H.V.; Baudis, L.; Dietz, A.; Heusser, G.; Krivosheina, I.; Majorovits, B.; Strecker, H.

    2002-01-01

    GENIUS is a proposal for a large scale detector of rare events. As a first step of the experiment, a small test version, the Genius Test-Facility will be built at the Laboratori Nazionali del Gran Sasso. With about 40 kg of natural Ge detectors operated in liquid nitrogen, GENIUS-TF could exclude (or directly confirm) the DAMA annual modulation seasonal modulation signature within about 2 yr of measurement using both, signal and signature of the claimed WIMP Dark Matter. The construction of the experiment has already been started, and four 2.5 kg germanium detectors with an extreme low threshold of 500 eV have been produced

  1. Shear strength of the ASDEX upgrade TF coil insulation: Rupture, fatigue and creep behaviour

    International Nuclear Information System (INIS)

    Streibl, B.; Maier, E.A.; Perchermeier, J.; Cimbrico, P.L.; Varni, G.; Pisani, D.; Deska, R.; Endreat, J.

    1987-03-01

    This report is concerned with the interlaminar shear strength of the insulation system for the 16 toroidal field (TF) coils of ASDEX upgrade. The interlaminar shear properties of the glass-epoxy insulation are primarily determined by the resin system (ARALDIT-F, HT 907, DZ 40) and its curing procedure. The pure resin was therefore tested first in tension. The results were taken into account for setting up the method of curing the TF coils. Shear tests of the complete glass-epopxy system were then conducted with tubular torque specimens providing a nearly homogeneous stress distribution. In particular, the influence of the amount of flexibilizer (5, 10, 15 parts of resin weight = PoW) on the rupture and fatigue strengths was assessed at a temperature T=60 C, as also was the temperature dependence of the creep rate (40 C, 60 C, 80 C). The results obtained are not based on safe statistics. Nevertheless, they show clear trends. (orig.)

  2. Simultaneous gains tuning in boiler/turbine PID-based controller clusters using iterative feedback tuning methodology.

    Science.gov (United States)

    Zhang, Shu; Taft, Cyrus W; Bentsman, Joseph; Hussey, Aaron; Petrus, Bryan

    2012-09-01

    Tuning a complex multi-loop PID based control system requires considerable experience. In today's power industry the number of available qualified tuners is dwindling and there is a great need for better tuning tools to maintain and improve the performance of complex multivariable processes. Multi-loop PID tuning is the procedure for the online tuning of a cluster of PID controllers operating in a closed loop with a multivariable process. This paper presents the first application of the simultaneous tuning technique to the multi-input-multi-output (MIMO) PID based nonlinear controller in the power plant control context, with the closed-loop system consisting of a MIMO nonlinear boiler/turbine model and a nonlinear cluster of six PID-type controllers. Although simplified, the dynamics and cross-coupling of the process and the PID cluster are similar to those used in a real power plant. The particular technique selected, iterative feedback tuning (IFT), utilizes the linearized version of the PID cluster for signal conditioning, but the data collection and tuning is carried out on the full nonlinear closed-loop system. Based on the figure of merit for the control system performance, the IFT is shown to deliver performance favorably comparable to that attained through the empirical tuning carried out by an experienced control engineer. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

  3. Tuning rules for robust FOPID controllers based on multi-objective optimization with FOPDT models.

    Science.gov (United States)

    Sánchez, Helem Sabina; Padula, Fabrizio; Visioli, Antonio; Vilanova, Ramon

    2017-01-01

    In this paper a set of optimally balanced tuning rules for fractional-order proportional-integral-derivative controllers is proposed. The control problem of minimizing at once the integrated absolute error for both the set-point and the load disturbance responses is addressed. The control problem is stated as a multi-objective optimization problem where a first-order-plus-dead-time process model subject to a robustness, maximum sensitivity based, constraint has been considered. A set of Pareto optimal solutions is obtained for different normalized dead times and then the optimal balance between the competing objectives is obtained by choosing the Nash solution among the Pareto-optimal ones. A curve fitting procedure has then been applied in order to generate suitable tuning rules. Several simulation results show the effectiveness of the proposed approach. Copyright © 2016. Published by Elsevier Ltd.

  4. Study for Manufacturing of ITER TF Coil Radial Plates

    International Nuclear Information System (INIS)

    Fietz, W.H.; Muetzel, W.

    2006-01-01

    During the previous design phase of ITER the ITER Toroidal Field Model Coil (TFMC) has been built to verify the TF coil concept of ITER and to proof the feasibility of an industrial fabrication of such a coil. In April 2004, Forschungszentrum and BNG, started a Manufacturing Study for the full scale Radial Plates (RP) of the TF Coils in the frame of an EFDA task. The main part of the Study was to develop feasible concepts of the technology for the manufacturing of the Full Scale Radial Plates starting with the raw material until final testing. The Feasibility Study has covered all manufacturing steps that are necessary for production of the RP. It has included as well a basic layout for the manufacturing process. During the work several proposals for the single manufacturing work steps have been developed. After that an evaluation of the found proposals has taken place. The most feasible proposals have been combined to manufacturing concepts. Finally two main Concepts were elaborated and evaluated: Concept 1 includes the premachining of segments with grooves, the welding of the segments and the final machining of the RP. Concept 2 includes the welding of not machined small segments to the D-shape of the RP and the following machining of the surface and grooves. Both Concepts will be described in detail with a comparison of tooling and manufacturing details, achievement of technological requirements as well as with the requirements coming from the overall time schedule. Based on the results of the assessment of the different concepts and manufacturing techniques Concept 1 shows some advantages compared to Concept 2. These will be described in the paper. In addition a proposal about additional R(and)D in front of the later manufacturing will be made. (author)

  5. Development of manufacturing technology for ITER TF Coil Structure

    Energy Technology Data Exchange (ETDEWEB)

    Sakurai, Takeru, E-mail: sakurai.takeru@jaea.go.jp; Iguchi, Masahide; Nakahira, Masataka; Inagaki, Takashi; Matsui, Kunihiro; Koizumi, Norikiyo

    2016-11-01

    Highlights: • Heavy thick welding (Max. 287 mm) was performed by balance welding. • Figured out Attachment welding deformation including heavy thick welding. • The deformation of Segments welding was suppressed to 1/3 of previous method. • Based on this study, JAEA started actual ITER TF coil structure manufacturing. - Abstract: Japan Atomic Energy Agency (JAEA) performed a trial of A1 Segment manufacturing of Toroidal Field (TF) coil structure, which is a piece with a radius of curvature 3 m with square channel for coil. Even though both-side welding (balance welding) was preferred to one-side welding considering the welding deformation, it could not be applied to the previous trial due to the difficulty of overhead or horizontal welding by machine. Hence, one-side welding with strong restriction jig was applied in the previous trials. In the latest trial, JAEA adopted a manual balance welding with a development of manufacturing technology. As the result of A1 Segment Mainbody welding trial, welding deformation of the Outer Plate and the Side Plate could have been controlled closer to the target value. JAEA also tried Attachments welding, in which Pre-Compression Flange (PCF) and Extension are welded to A1 Segment Mainbody, and a Segments welding trial, which is a weld between A1 Segment and a part of A2 Segment. A2 Segment is a 3 m straight part with square channel for coil. The inclination of A1 Segment and A2 Segment due to the welding was 2.7 mm. By applying balance welding, the deformation by Segments welding was suppressed to about 1/3 of the one-side welding. The views and opinions expressed herein do not necessarily reflect those of the ITER Organization.

  6. Structural modelling and molecular dynamics of a multi-stress responsive WRKY TF-DNA complex towards elucidating its role in stress signalling mechanisms in chickpea.

    Science.gov (United States)

    Konda, Aravind Kumar; Farmer, Rohit; Soren, Khela Ram; P S, Shanmugavadivel; Setti, Aravind

    2017-07-28

    Chickpea is a premier food legume crop with high nutritional quality and attains prime importance in the current era of 795 million people being undernourished worldwide. Chickpea production encounters setbacks due to various stresses and understanding the role of key transcription factors (TFs) involved in multiple stresses becomes inevitable. We have recently identified a multi-stress responsive WRKY TF in chickpea. The present study was conducted to predict the structure of WRKY TF to identify the DNA-interacting residues and decipher DNA-protein interactions. Comparative modelling approach produced 3D model of the WRKY TF with good stereochemistry, local/global quality and further revealed W19, R20, K21, and Y22 motifs within a vicinity of 5 Å to the DNA amongst R18, G23, Q24, K25, Y36, Y37, R38 and K47 and these positions were equivalent to the 2LEX WRKY domain of Arabidopsis. Molecular simulations analysis of reference protein -PDB ID 2LEX, along with Car-WRKY TF modelled structure with the DNA coordinates derived from PDB ID 2LEX and docked using HADDOCK were executed. Root Mean Square (RMS) Deviation and RMS Fluctuation values yielded consistently stable trajectories over 50 ns simulation. Strengthening the obtained results, neither radius of gyration, distance and total energy showed any signs of DNA-WRKY complex falling apart nor any significant dissociation event over 50 ns run. Therefore, the study provides first insights into the structural properties of multi-stress responsive WRKY TF-DNA complex in chickpea, enabling genome wide identification of TF binding sites and thereby deciphers their gene regulatory networks.

  7. Adaptive Self-Tuning Networks

    Science.gov (United States)

    Knox, H. A.; Draelos, T.; Young, C. J.; Lawry, B.; Chael, E. P.; Faust, A.; Peterson, M. G.

    2015-12-01

    The quality of automatic detections from seismic sensor networks depends on a large number of data processing parameters that interact in complex ways. The largely manual process of identifying effective parameters is painstaking and does not guarantee that the resulting controls are the optimal configuration settings. Yet, achieving superior automatic detection of seismic events is closely related to these parameters. We present an automated sensor tuning (AST) system that learns near-optimal parameter settings for each event type using neuro-dynamic programming (reinforcement learning) trained with historic data. AST learns to test the raw signal against all event-settings and automatically self-tunes to an emerging event in real-time. The overall goal is to reduce the number of missed legitimate event detections and the number of false event detections. Reducing false alarms early in the seismic pipeline processing will have a significant impact on this goal. Applicable both for existing sensor performance boosting and new sensor deployment, this system provides an important new method to automatically tune complex remote sensing systems. Systems tuned in this way will achieve better performance than is currently possible by manual tuning, and with much less time and effort devoted to the tuning process. With ground truth on detections in seismic waveforms from a network of stations, we show that AST increases the probability of detection while decreasing false alarms.

  8. The ATLAS Monte Carlo tuning system

    CERN Document Server

    Wahrmund, S

    2012-01-01

    The ATLAS experiment moved the tuning of the underlying event and minimum bias event shape modeling, previously done in a manual fashion, to the automated Professor tuning tool, employed in connection with the Rivet analysis framework, when the first corresponding experimental analysis from LHC became available. The tuning effort for the Pythia 8 generator, which includes improved models for diffraction, has been started in this automated way in ATLAS, with the aim of getting a good description of the pile-up generated by multiple minimum bias interactions. The first results for these Pythia 8 tunes, as well as Pythia 6 shower tunes are presented, including a study of tunes for various PDFs.

  9. BRIEF COMMUNICATION: Electrothermal bistability tuning in a large displacement micro actuator

    Science.gov (United States)

    Gerson, Y.; Krylov, S.; Ilic, B.

    2010-11-01

    We report on an approach allowing simple yet efficient tuning of the bistability properties in large displacement micro actuators. The devices fabricated from silicon on insulator (SOI) wafers using a deep reactive ion etching (DRIE)-based process incorporate elastic suspension realized as a pair of beams initially curved in-plane and are operated electrostatically by a comb-drive transducer. The curvature of beam and therefore the stability characteristics of the suspension are controlled by passing a current through the suspension and resistive heating the beam material. Experimental results, which are in good agreement with the finite elements model predictions, demonstrate the feasibility of the suggested approach and show that the application of a small tuning current increases the device deflection from 42 to 56 µm, allows adjustment of the critical snap-through and snap-back voltages and makes it possible the control of latching without an additional electrode. The approach can be efficiently implemented in electrical and optical switches and threshold inertial and mass sensors where the use of long displacement actuators with an adjustable bistability range is beneficial.

  10. Uji Unjuk Kerja Traktor Yanmar Tipe TF 85 pada Lahan Basah dan Lahan Kering di Desa Dolok Hataran, Kabupaten Simalungun

    OpenAIRE

    Tobing, Toman Harry Duga L.

    2010-01-01

    TOMAN H D L. TOBING: Performance of Yanmar TF 85 Tractor on Wet land and Dry land at Desa Dolok Hataran Kabupaten Simalungun. Under the supervision of TAUFIK RIZALDI and AINUN ROHANAH. The performance test of tractor is its ability to prepare land using implements to know the work capacity, efficiency, work velocity, and wheel skid. The objective of this research is to know the capacity of Yanmar TF 85 tractor on wet land and dry land at Desa Dolok Hataran Kabupaten Simalungun. This rese...

  11. tf_unet: Generic convolutional neural network U-Net implementation in Tensorflow

    Science.gov (United States)

    Akeret, Joel; Chang, Chihway; Lucchi, Aurelien; Refregier, Alexandre

    2016-11-01

    tf_unet mitigates radio frequency interference (RFI) signals in radio data using a special type of Convolutional Neural Network, the U-Net, that enables the classification of clean signal and RFI signatures in 2D time-ordered data acquired from a radio telescope. The code is not tied to a specific segmentation and can be used, for example, to detect radio frequency interference (RFI) in radio astronomy or galaxies and stars in widefield imaging data. This U-Net implementation can outperform classical RFI mitigation algorithms.

  12. Comparison of different tube-of-response (TOR) models for resolution recovery in PET image reconstruction for the Philips Ingenuity TF PET/MR

    International Nuclear Information System (INIS)

    Lougovski, Alexandr; Hofheinz, Frank; Van Den Hoff, Jorg

    2015-01-01

    Recently, we have proposed a method for on-the-fly system matrix computation where the tube-of-response (TOR) is approximated as a cylinder with constant density (TORCD) and the cubic voxels are replaced by spheres. We could show that with this model the PET image quality can be notably improved compared to the vendor provided image reconstruction of our Philips Ingenuity-TF PET/MR. In this work we address the question whether image quality can be further improved by using a variable density TOR (TOR-VD). The radial variability of TOR-VD was modelled by a Kaiser-Bessel function. Free parameters of this density model were used to optimize image properties regarding resolution, noise, and Gibbs artifacts. Additional, a TOR-VD model accounting for position dependent effects along the TOR caused by the finite solid angles of the detectors is under investigation. Phantom measurement were performed with a Philips Ingenuity-TF PET/MR scanner. Listmode data were reconstructed using TOR-CD and TORVD, respectively on two different grids with cubic voxel size of 2 mm and 4 mm. Image quality was assessed with resolution-noise curves and investigation of the radial position dependence of the spatial resolution. For 2 mm voxels, TOR-VD consistently yields a slight improvement of the investigated image quality measures compared to TOR-CD. For 4 mm voxels both models lead essentially to the same results. These findings can be understood as a consequence of the relative size of voxel and TOR. For typical whole body studies (4 mm voxel size) a variable TOR does not improve image quality beyond what is achievable with a constant density TOR. For smaller voxel size the image quality can indeed be somewhat improved with a variable TOR but at the expense of drastically increased computation time.

  13. Comparison of different tube-of-response (TOR) models for resolution recovery in PET image reconstruction for the Philips Ingenuity TF PET/MR

    Energy Technology Data Exchange (ETDEWEB)

    Lougovski, Alexandr; Hofheinz, Frank; Van Den Hoff, Jorg [Helmholtz-Center Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, PET Center, Dresden (Germany)

    2015-05-18

    Recently, we have proposed a method for on-the-fly system matrix computation where the tube-of-response (TOR) is approximated as a cylinder with constant density (TORCD) and the cubic voxels are replaced by spheres. We could show that with this model the PET image quality can be notably improved compared to the vendor provided image reconstruction of our Philips Ingenuity-TF PET/MR. In this work we address the question whether image quality can be further improved by using a variable density TOR (TOR-VD). The radial variability of TOR-VD was modelled by a Kaiser-Bessel function. Free parameters of this density model were used to optimize image properties regarding resolution, noise, and Gibbs artifacts. Additional, a TOR-VD model accounting for position dependent effects along the TOR caused by the finite solid angles of the detectors is under investigation. Phantom measurement were performed with a Philips Ingenuity-TF PET/MR scanner. Listmode data were reconstructed using TOR-CD and TORVD, respectively on two different grids with cubic voxel size of 2 mm and 4 mm. Image quality was assessed with resolution-noise curves and investigation of the radial position dependence of the spatial resolution. For 2 mm voxels, TOR-VD consistently yields a slight improvement of the investigated image quality measures compared to TOR-CD. For 4 mm voxels both models lead essentially to the same results. These findings can be understood as a consequence of the relative size of voxel and TOR. For typical whole body studies (4 mm voxel size) a variable TOR does not improve image quality beyond what is achievable with a constant density TOR. For smaller voxel size the image quality can indeed be somewhat improved with a variable TOR but at the expense of drastically increased computation time.

  14. SC tuning fork

    CERN Document Server

    The tuning fork used to modulate the radiofrequency system of the synchro cyclotron (SC) from 1957 to 1973. This piece is an unused spare part. The SC was the 1st accelerator built at CERN. It operated from August 1957 until it was closed down at the end of 1990. In the SC the magnetic field did not change with time, and the particles were accelerated in successive pulses by a radiofrequency voltage of some 20kV which varied in frequency as they spiraled outwards towards the extraction radius. The frequency varied from 30MHz to about 17Mz in each pulse. The tuning fork vibrated at 55MHz in vacuum in an enclosure which formed a variable capacitor in the tuning circuit of the RF system, allowing the RF to vary over the appropriate range to accelerate protons from the centre of the macine up to 600Mev at extraction radius. In operation the tips of the tuning fork blade had an amplitude of movement of over 1 cm. The SC accelerator underwent extensive improvements from 1973 to 1975, including the installation of a...

  15. TIBER-II TF [toroidal-field] winding pack design

    International Nuclear Information System (INIS)

    Kerns, J.A.; Miller, J.R.; Slack, D.S.; Summers, L.T.

    1987-01-01

    The superconducting, toroidal-field (TF) coils in the Tokamak Ignition/Burn Engineering Reactor (TIBER II) are designed with cable-in-conduit conductor (CICC) using Nb 3 Sn composite strands. To design the CICC winding pack, we used an optimization technique that maximizes the conductor stability without violating the constraints imposed by the structure, electrical insulation, quench protection, and fabrication technique. Detailed helium-properties codes calculate the heat removal along a flow path, and detailed field calculations determine the temperature, current, and stability margins. The conductor sheath is designed as distributed structure to partially support the combined in-plane and out-of-plane loads generated within the winding pack. Pancakes of the coil are wound, reacted, and insulated before being potted in the case. This design is aggressive but fully consistent with good engineering practice. 5 refs., 4 figs., 2 tabs

  16. TFTR D and D Project: Final Examination and Testing of the TFTR TF-Coils

    International Nuclear Information System (INIS)

    Zatz, Irving J.

    2003-01-01

    In operation for nearly 15 years, TFTR (Tokamak Fusion Test Reactor) was not only a fusion science milestone, but a milestone of achievement in engineering as well. The TFTR DandD (Decommissioning and Decontamination) program provided a rare opportunity to examine machine components that had been exposed to a unique performance environment of greater than 100,000 mechanical and thermal load cycles. In particular, the possible examination of the TFTR toroidal-field (TF) coils, which met, then exceeded, the 5.2 Tesla magnetic field machine specification, could supply the answers to many questions that have been asked and debated since the coils were originally designed and built. A test program conducted in parallel with the DandD effort was the chance to look inside and examine, in detail, the TFTR TF coils for the first time since they were delivered encased to PPPL (Princeton Plasma Physics Laboratory). The results from such a program would provide data and insight that would not only be nefit PPPL and the fusion community, but the broader scientific community as well

  17. Preliminary LOCA analysis of the westinghouse small modular reactor using the WCOBRA/TRAC-TF2 thermal-hydraulics code

    Energy Technology Data Exchange (ETDEWEB)

    Liao, J.; Kucukboyaci, V. N.; Nguyen, L.; Frepoli, C. [Westinghouse Electric Company, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

    2012-07-01

    The Westinghouse Small Modular Reactor (SMR) is an 800 MWt (> 225 MWe) integral pressurized water reactor (iPWR) with all primary components, including the steam generator and the pressurizer located inside the reactor vessel. The reactor core is based on a partial-height 17x17 fuel assembly design used in the AP1000{sup R} reactor core. The Westinghouse SMR utilizes passive safety systems and proven components from the AP1000 plant design with a compact containment that houses the integral reactor vessel and the passive safety systems. A preliminary loss of coolant accident (LOCA) analysis of the Westinghouse SMR has been performed using the WCOBRA/TRAC-TF2 code, simulating a transient caused by a double ended guillotine (DEG) break in the direct vessel injection (DVI) line. WCOBRA/TRAC-TF2 is a new generation Westinghouse LOCA thermal-hydraulics code evolving from the US NRC licensed WCOBRA/TRAC code. It is designed to simulate PWR LOCA events from the smallest break size to the largest break size (DEG cold leg). A significant number of fluid dynamics models and heat transfer models were developed or improved in WCOBRA/TRAC-TF2. A large number of separate effects and integral effects tests were performed for a rigorous code assessment and validation. WCOBRA/TRAC-TF2 was introduced into the Westinghouse SMR design phase to assist a quick and robust passive cooling system design and to identify thermal-hydraulic phenomena for the development of the SMR Phenomena Identification Ranking Table (PIRT). The LOCA analysis of the Westinghouse SMR demonstrates that the DEG DVI break LOCA is mitigated by the injection and venting from the Westinghouse SMR passive safety systems without core heat up, achieving long term core cooling. (authors)

  18. Two-phase interfacial area and flow regime modeling in FLOWTRAN-TF code

    International Nuclear Information System (INIS)

    Smith, F.G. III; Lee, S.Y.; Flach, G.P.; Hamm, L.L.

    1992-01-01

    FLOWTRAN-TF is a new two-component, two-phase thermal-hydraulics code to capture the detailed assembly behavior associated with loss-of-coolant accident analyses in multichannel assemblies of the SRS reactors. The local interfacial area of the two-phase mixture is computed by summing the interfacial areas contributed by each of three flow regimes. For smooth flow regime transitions, the code uses an interpolation technique in terms of component void fraction for each basic flow regime

  19. Long adaptation reveals mostly attractive shifts of orientation tuning in cat primary visual cortex.

    Science.gov (United States)

    Ghisovan, N; Nemri, A; Shumikhina, S; Molotchnikoff, S

    2009-12-15

    In the adult brain, sensory cortical neurons undergo transient changes of their response properties following prolonged exposure to an appropriate stimulus (adaptation). In cat V1, orientation-selective cells shift their preferred orientation after being adapted to a non-preferred orientation. There are conflicting reports as to the direction of those shifts, towards (attractive) or away (repulsive) from the adapter. Moreover, the mechanisms underlying attractive shifts remain unexplained. In the present investigation we show that attractive shifts are the most frequent outcome of a 12 min adaptation. Overall, cells displaying selectivity for oblique orientations exhibit significantly larger shifts than cells tuned to cardinal orientations. In addition, cells selective to cardinal orientations had larger shift amplitudes when the absolute difference between the original preferred orientation and the adapting orientation increased. Conversely, cells tuned to oblique orientations exhibited larger shift amplitudes when this absolute orientation difference was narrower. Hence, neurons tuned to oblique contours appear to show more plasticity in response to small perturbations. Two different mechanisms appear to produce attractive and repulsive orientation shifts. Attractive shifts result from concurrent response depression on the non-adapted flank and selective response facilitation on the adapted flank of the orientation tuning curve. In contrast, repulsive shifts are caused solely by response depression on the adapted flank. We suggest that an early mechanism leads to repulsive shifts while attractive shifts engage a subsequent late facilitation. A potential role for attractive shifts may be improved stimulus discrimination around the adapting orientation.

  20. Data Driven Tuning of Inventory Controllers

    DEFF Research Database (Denmark)

    Huusom, Jakob Kjøbsted; Santacoloma, Paloma Andrade; Poulsen, Niels Kjølstad

    2007-01-01

    A systematic method for criterion based tuning of inventory controllers based on data-driven iterative feedback tuning is presented. This tuning method circumvent problems with modeling bias. The process model used for the design of the inventory control is utilized in the tuning...... as an approximation to reduce time required on experiments. The method is illustrated in an application with a multivariable inventory control implementation on a four tank system....

  1. Magnetically tuned mass dampers for optimal vibration damping of large structures

    International Nuclear Information System (INIS)

    Bourquin, Frederic; Siegert, Dominique; Caruso, Giovanni; Peigney, Michael

    2014-01-01

    This paper deals with the theoretical and experimental analysis of magnetically tuned mass dampers, applied to the vibration damping of large structures of civil engineering interest. Two devices are analysed, for which both the frequency tuning ratio and the damping coefficient can be easily and finely calibrated. They are applied for the damping of the vibrations along two natural modes of a mock-up of a bridge under construction. An original analysis, based on the Maxwell receding image method, is developed for estimating the drag force arising inside the damping devices. It also takes into account self-inductance effects, yielding a complex nonlinear dependence of the drag force on the velocity. The analysis highlights the range of velocities for which the drag force can be assumed of viscous type, and shows its dependence on the involved geometrical parameters of the dampers. The model outcomes are then compared to the corresponding experimental calibration curves. A dynamic model of the controlled structure equipped with the two damping devices is presented, and used for the development of original optimization expressions and for determining the corresponding maximum achievable damping. Finally, several experimental results are presented, concerning both the free and harmonically forced vibration damping of the bridge mock-up, and compared to the corresponding theoretical predictions. The experimental results reveal that the maximum theoretical damping performance can be achieved, when both the tuning frequencies and damping coefficients of each device are finely calibrated according to the optimization expressions. (paper)

  2. Transverse betatron tune measurements

    International Nuclear Information System (INIS)

    Serio, M.

    1989-01-01

    In this paper the concept of the betatron tune and the techniques to measure it are discussed. The smooth approximation is introduced along with the terminology of betatron oscillations, phase advance and tune. Single particle and beam spectra in the presence of synchro-betatron oscillations are treated with emphasis on the consequences of sampling the beam position. After a general presentation of various kinds of beam position monitors and transverse kickers, the time domain and frequency domain analysis of the beam response to a transverse excitation are discussed and several methods and applications of the tune measurements are listed

  3. The ATLAS Monte Carlo tuning system

    CERN Document Server

    Wahrmund, S; The ATLAS collaboration

    2011-01-01

    The ATLAS experiment moved the tuning of the underlying event and minimum bias event shape modeling, previously done in a manual fashion, to the automated Professor tuning tool, employed in connection with the Rivet analysis framework, when the first corresponding experimental analysis from LHC became available. The tuning effort for the Pythia 8 generator, which includes improved models for diffraction, has been started in this automated way in ATLAS, with the aim of getting a good description of the pile-up generated by multiple minimum bias interactions. The first results for these Pythia 8 tunes are presented, including a study of tunes for various PDFs.

  4. Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted).

    Science.gov (United States)

    Ark, B; Gummere, G; Bennett, D; Artzt, K

    1991-06-01

    Pim-1 is an oncogene activated in mouse T-cell lymphomas induced by Moloney and AKR mink cell focus (MCF) viruses. Pim-1 was previously mapped to chromosome 17 by somatic cell hybrids, and subsequently to the region between the hemoglobin alpha-chain pseudogene 4 (Hba-4ps) and the alpha-crystalline gene (Crya-1) by Southern blot analysis of DNA obtained from panels of recombinant inbred strains. We have now mapped Pim-1 more accurately in t-haplotypes by analysis of recombinant t-chromosomes. The recombinants were derived from Tts6tf/t12 parents backcrossed to + tf/ + tf, and scored for recombination between the loci of T and tf. For simplicity all t-complex lethal genes properly named tcl-tx are shortened to tx. The Pim-1 gene was localized 0.6 cM proximal to the tw12 lethal gene, thus placing the Pim-1 gene 5.2 cM distal to the H-2 region in t-haplotypes. Once mapped, the Pim-1 gene was used as a marker for further genetic analysis of t-haplotypes. tw12 is so close to tf that even with a large number of recombinants it was not possible to determine whether it is proximal or distal to tf. Southern blot analysis of DNA from T-tf recombinants with a separation of tw12 and tf indicated that tw12 is proximal to tf. The mapping of two allelic t-lethals, t0 and t6 with respect to tw12 and tf has also been a problem.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Tuning magnet power supply

    International Nuclear Information System (INIS)

    Han, B.M.; Karady, G.G.; Thiessen, H.A.

    1989-01-01

    The particles in a Rapid Cycling Accelerator are accelerated by rf cavities, which are tuned by dc biased ferrite cores. The tuning is achieved by the regulation of bias current, which is produced by a power supply. The tuning magnet power supply utilizes a bridge circuit, supplied by a three phase rectifier. During the rise of the current, when the particles are accelerated, the current is controlled with precision by the bridge which operates a power amplifier. During the fall of the current, the bridge operates in a switching mode and recovers the energy stored in the ferrites. The recovered energy is stored in a capacitor bank. The bridge circuit is built with 150 power transistors. The drive, protection and control circuit were designed and built from commercial component. The system will be used for a rf cavity experiment in Los Alamos and will serve as a prototype tuning power supply for future accelerators. 1 ref., 7 figs

  6. Curved Piezoelectric Actuators for Stretching Optical Fibers

    Science.gov (United States)

    Allison, Sidney G.; Shams, Qamar A.; Fox, Robert L.

    2008-01-01

    Assemblies containing curved piezoceramic fiber composite actuators have been invented as means of stretching optical fibers by amounts that depend on applied drive voltages. Piezoceramic fiber composite actuators are conventionally manufactured as sheets or ribbons that are flat and flexible, but can be made curved to obtain load-carrying ability and displacement greater than those obtainable from the flat versions. In the primary embodiment of this invention, piezoceramic fibers are oriented parallel to the direction of longitudinal displacement of the actuators so that application of drive voltage causes the actuator to flatten, producing maximum motion. Actuator motion can be transmitted to the optical fiber by use of hinges and clamp blocks. In the original application of this invention, the optical fiber contains a Bragg grating and the purpose of the controlled stretching of the fiber is to tune the grating as part of a small, lightweight, mode-hop-free, rapidly tunable laser for demodulating strain in Bragg-grating strain-measurement optical fibers attached to structures. The invention could also be used to apply controllable tensile force or displacement to an object other than an optical fiber.

  7. Avaliação do kit "TF-Test" para o diagnóstico das infecções por parasitas gastrintestinais em ovinos

    Directory of Open Access Journals (Sweden)

    Giuliano Lumina

    2006-08-01

    Full Text Available Este estudo teve como objetivos padronizar o kit TF-Test para a quantificação de ovos de parasitas gastrintestinais de ovinos e compará-lo ao método de Gordon & Whitlock modificado (G&W. Vinte quatro cordeiros confinados foram infectados artificialmente com Haemonchus contortus, durante 12 semanas, até o abate, quando foram colhidas amostras fecais e realizada a identificação e contagem dos parasitas abomasais. Nestes animais, ovos de H. contortus foram detectados em 95,8% das amostras fecais por ambos os testes (P>;0,05. Os coeficientes de correlação (r entre a carga parasitária (CP e os valores de OPG obtidos pelos métodos de G&W e TF-Test foram, respectivamente, de r=0,52 e r=0,51 (dados não transformados e r=0,85 e r=0,87 (dados transformados em log. Outras 100 amostras fecais foram colhidas de ovinos naturalmente infectados. Nas amostras destes animais, os testes G&W e TF-Test propiciaram o diagnóstico de ovos de estrongilídeos em 85% e 86% das amostras, respectivamente (P>;0,05. Pelo TF-Test e pelo G&W, oocistos de Eimeria foram detectados em 33% e em 12% das amostras (P<0,001 e ovos de Strongyloides spp. em 15% e 5% das amostras, respectivamente (P<0,05. Ambos os testes foram precisos para o diagnóstico de estrongilídeos gastrintestinais, porém, o TF-Test foi superior para o diagnóstico de oocistos de Eimeria spp. e de ovos de Strongyloides spp., mas, por outro lado, subestimou o número de ovos de estrongilídeos presente nas amostras.

  8. ATLAS Run 1 Pythia8 tunes

    CERN Document Server

    The ATLAS collaboration

    2014-01-01

    We present tunes of the Pythia8 Monte~Carlo event generator's parton shower and multiple parton interaction parameters to a range of data observables from ATLAS Run 1. Four new tunes have been constructed, corresponding to the four leading-order parton density functions, CTEQ6L1, MSTW2008LO, NNPDF23LO, and HERAPDF15LO, each simultaneously tuning ten generator parameters. A set of systematic variations is provided for the NNPDF tune, based on the eigentune method. These tunes improve the modeling of observables that can be described by leading-order + parton shower simulation, and are primarily intended for use in situations where next-to-leading-order and/or multileg parton-showered simulations are unavailable or impractical.

  9. Assessing apical transportation in curved canals: comparison between cross-sections and micro-computed tomography

    Directory of Open Access Journals (Sweden)

    Laila Gonzales Freire

    2012-06-01

    Full Text Available The aim of this study was to compare two methods of assessing apical transportation in curved canals after rotary instrumentation, namely, cross-sections and micro-computed tomography (µCT. Thirty mandibular molars were divided into two groups and prepared according to the requirements of each method. In G1 (cross-sections, teeth were embedded in resin blocks and sectioned at 2.0, 3.5, and 5.0 mm from the anatomic apex. Pre- and postoperative sections were photographed and analyzed. In G2 (µCT, teeth were embedded in a rubber-base impression material and scanned before and after instrumentation. Mesiobuccal canals were instrumented with the Twisted File (TF system (SybronEndo, Orange, USA, and mesiolingual canals, with the EndoSequence (ES system (Brasseler, Savannah, USA. Images were reconstructed, and sections corresponding to distances 2.0, 3.5, and 5.0 mm from the anatomic apex were selected for comparison. Data were analyzed using Mann-Whitney's test at a 5% significance level. The TF and ES instruments produced little deviation from the root canal center, with no statistical difference between them (P > 0.05. The canal transportation results were significantly lower (0.056 mm in G2 than in G1 (0.089 mm (p = 0.0012. The µCT method was superior to the cross-section method, especially in view of its ability to preserve specimens and provide results that are more closely related to clinical situations.

  10. Robust Self Tuning Controllers

    DEFF Research Database (Denmark)

    Poulsen, Niels Kjølstad

    1985-01-01

    The present thesis concerns robustness properties of adaptive controllers. It is addressed to methods for robustifying self tuning controllers with respect to abrupt changes in the plant parameters. In the thesis an algorithm for estimating abruptly changing parameters is presented. The estimator...... has several operation modes and a detector for controlling the mode. A special self tuning controller has been developed to regulate plant with changing time delay.......The present thesis concerns robustness properties of adaptive controllers. It is addressed to methods for robustifying self tuning controllers with respect to abrupt changes in the plant parameters. In the thesis an algorithm for estimating abruptly changing parameters is presented. The estimator...

  11. Improvements to the COBRA-TF (EPRI) computer code for steam generator analysis. Final report

    International Nuclear Information System (INIS)

    Stewart, C.W.; Barnhart, J.S.; Koontz, A.S.

    1980-09-01

    The COBRA-TF (EPRI) code has been improved and extended for pressurized water reactor steam generator analysis. New features and models have been added in the areas of subcooled boiling and heat transfer, turbulence, numerics, and global steam generator modeling. The code's new capabilities are qualified against selected experimental data and demonstrated for typical global and microscale steam generator analysis

  12. Pre-tuning of TRISTAN superconducting RF cavities

    International Nuclear Information System (INIS)

    Tajima, Tsuyoshi; Furuya, Takaaki; Suzuki, Toshiji; Iino, Yohsuke.

    1990-01-01

    Pre-tuning of thirty-two TRISTAN superconducting cavities has been done. In this paper are described the pre-tuning system and the results of all the cavities. The average field flatness was 1.4 % after pre-tuning. From our experience, the followings are important, 1) to evacuate the cavity during the process of the pre-tuning to avoid the uncertainty in evacuation, 2) pre-tuning is needed after annealing because it causes changes of the cell length and the field profile and 3) field flatness sometimes changes when expanded and 4) cells should not be expanded more than 1.5 mm after pre-tuning since inelastic deformation occurs. (author)

  13. How safe is tuning a radio?: using the radio tuning task as a benchmark for distracted driving.

    Science.gov (United States)

    Lee, Ja Young; Lee, John D; Bärgman, Jonas; Lee, Joonbum; Reimer, Bryan

    2018-01-01

    Drivers engage in non-driving tasks while driving, such as interactions entertainment systems. Studies have identified glance patterns related to such interactions, and manual radio tuning has been used as a reference task to set an upper bound on the acceptable demand of interactions. Consequently, some view the risk associated with radio tuning as defining the upper limit of glance measures associated with visual-manual in-vehicle activities. However, we have little knowledge about the actual degree of crash risk that radio tuning poses and, by extension, the risk of tasks that have similar glance patterns as the radio tuning task. In the current study, we use counterfactual simulation to take the glance patterns for manual radio tuning tasks from an on-road experiment and apply these patterns to lead-vehicle events observed in naturalistic driving studies. We then quantify how often the glance patterns from radio tuning are associated with rear-end crashes, compared to driving only situations. We used the pre-crash kinematics from 34 crash events from the SHRP2 naturalistic driving study to investigate the effect of radio tuning in crash-imminent situations, and we also investigated the effect of radio tuning on 2,475 routine braking events from the Safety Pilot project. The counterfactual simulation showed that off-road glances transform some near-crashes that could have been avoided into crashes, and glance patterns observed in on-road radio tuning experiment produced 2.85-5.00 times more crashes than baseline driving. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Dynamic force microscopy with quartz tuning forks at high oscillation amplitudes

    International Nuclear Information System (INIS)

    Labardi, M

    2007-01-01

    Dynamic force microscopy (DFM) with the self-oscillator (SO) method allows reasonably high scanning rates even with high Q-factors of the resonant force sensor, typical of cantilevers in ultra-high vacuum and of quartz tuning forks. However, due to simpler interpretation of force spectroscopy measurements, small oscillation amplitudes (sub-nm level) are generally preferred. In applications like 'apertureless' scanning near-field optical microscopy (SNOM), oscillation amplitudes of the order of 5-10 nm are needed to increase optical sensitivity and to apply standard optical artefact suppression methods. This motivates the study of the behaviour of tuning forks driven at such high amplitudes, as compared to usual air-operated cantilevers. Both constant-excitation-amplitude (CE) and constant-oscillation-amplitude (CA) modes of SO-DFM are analysed, since the CA mode is more convenient for SNOM applications, denoting remarkable differences. In particular, possible instability effects, previously found in CE mode, are not anticipated for CA mode. It is shown how resonance and approach ('isophase') curves in both modes can be conveniently described in terms of the usual 'normalized frequency shift' γ and of a 'normalized gain' η, defined as a measurement of surface dissipation

  15. Stability of [MeBu{sub 3}N][Tf{sub 2}N] under gamma irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Bosse, Emilie; Berthon, Laurence; Zorz, Nicole; Monget, Julie; Berthon, Claude; Bisel, Isabelle; Legand, Solene; Moisy, Philippe [CEA Marcoule, DCRP/SCPS, BP 17171, 30207 Bagnols sur Ceze Cedex (France)

    2008-07-01

    The stability of the ionic liquid [MeBu{sub 3}N][Tf{sub 2}N], dry or after contact with water (where [MeBu{sub 3}N]{sup +} is the methyl-tributyl-ammonium cation and [Tf{sub 2}N]{sup -} is the bistriflimide anion), was studied under {sup 137}Cs gamma irradiation in argon and in air. In a quantitative study with an absorbed dose of 2 MGy this ionic liquid was highly stable regardless of the radiolysis conditions. The radiolytic disappearance yields determined by ESI-MS were -0.38 and -0.25 {mu}mol*J{sup -1} for the cation and anion, respectively. ESI-MS, NMR, and liquid chromatography coupled with ESI-MS identified a large number of degradation products in very small quantities for the same dose. The cation radicals were formed by the loss of a Bu{sup .} group, the Me{sup .} group, or two H{sup .} atoms to form a double bond with the butyl chain. Radiolysis of the anion produced mainly F{sup .} and CF{sub 3}{sup .} radicals. The anion radicals recombined with the cation to form a wide range of secondary degradation products regardless of the radiolysis conditions. (authors)

  16. Engineering, Manufacture and Preliminary Testing of the ITER Toroidal Field (TF) Magnet Helium Cold Circulator

    Science.gov (United States)

    Rista, P. E. C.; Shull, J.; Sargent, S.

    2015-12-01

    The ITER cryodistribution system provides the supercritical Helium (SHe) forced flow cooling to the magnet system using cold circulators. The cold circulators are located in each of five separate auxiliary cold boxes planned for use in the facility. Barber-Nichols Inc. has been awarded a contract from ITER-India for engineering, manufacture and testing of the Toroidal Field (TF) Magnet Helium Cold Circulator. The cold circulator will be extensively tested at Barber-Nichols’ facility prior to delivery for qualification testing at the Japan Atomic Energy Agency's (JAEA) test facility at Naka, Japan. The TF Cold Circulator integrates features and technical requirements which Barber-Nichols has utilized when supplying helium cold circulators worldwide over a period of 35 years. Features include a vacuum-jacketed hermetically sealed design with a very low helium leak rate, a heat shield for use with both nitrogen & helium cold sources, a broad operating range with a guaranteed isentropic efficiency over 70%, and impeller design features for high efficiency. The cold circulator will be designed to meet MTBM of 17,500 hours and MTBF of 36,000 hours. Vibration and speed monitoring are integrated into a compact package on the rotating assembly with operation and health monitoring in a multi-drop PROFIBUS communication environment using an electrical cabinet with critical features and full local and network PLC interface and control. For the testing in Japan and eventual installation in Europe, the cold circulator must be certified to the Japanese High Pressure Gas Safety Act (JHPGSA) and CE marked in compliance with the European Pressure Equipment Directive (PED) including Essential Safety Requirements (ESR). The test methodology utilized at Barber-Nichols’ facility and the resulting test data, validating the high efficiency of the TF Cold Circulator across a broad operating range, are important features of this paper.

  17. Engineering, Manufacture and Preliminary Testing of the ITER Toroidal Field (TF) Magnet Helium Cold Circulator

    International Nuclear Information System (INIS)

    C Rista, P E; Shull, J; Sargent, S

    2015-01-01

    The ITER cryodistribution system provides the supercritical Helium (SHe) forced flow cooling to the magnet system using cold circulators. The cold circulators are located in each of five separate auxiliary cold boxes planned for use in the facility. Barber-Nichols Inc. has been awarded a contract from ITER-India for engineering, manufacture and testing of the Toroidal Field (TF) Magnet Helium Cold Circulator. The cold circulator will be extensively tested at Barber-Nichols’ facility prior to delivery for qualification testing at the Japan Atomic Energy Agency's (JAEA) test facility at Naka, Japan. The TF Cold Circulator integrates features and technical requirements which Barber-Nichols has utilized when supplying helium cold circulators worldwide over a period of 35 years. Features include a vacuum-jacketed hermetically sealed design with a very low helium leak rate, a heat shield for use with both nitrogen and helium cold sources, a broad operating range with a guaranteed isentropic efficiency over 70%, and impeller design features for high efficiency. The cold circulator will be designed to meet MTBM of 17,500 hours and MTBF of 36,000 hours. Vibration and speed monitoring are integrated into a compact package on the rotating assembly with operation and health monitoring in a multi-drop PROFIBUS communication environment using an electrical cabinet with critical features and full local and network PLC interface and control. For the testing in Japan and eventual installation in Europe, the cold circulator must be certified to the Japanese High Pressure Gas Safety Act (JHPGSA) and CE marked in compliance with the European Pressure Equipment Directive (PED) including Essential Safety Requirements (ESR). The test methodology utilized at Barber-Nichols’ facility and the resulting test data, validating the high efficiency of the TF Cold Circulator across a broad operating range, are important features of this paper. (paper)

  18. Betatron tune measurement

    International Nuclear Information System (INIS)

    Dinev, D.

    2001-01-01

    On the basis of the comparative review of the methods for the betatron tune measurement in cyclic accelerators of synchrotrons type, the research of these methods is carried out from the point of view of their applicability to Nuclotron. Both methods using measurement of the statistical fluctuations of the beam current (Schottky noise) and methods using coherent beam excitation have been discussed. The emphasis is on the final results of importance for the tune measurement practice. Signal processing is briefly discussed too

  19. Upgrades to PEP-II Tune Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Alan S.

    2002-07-30

    The tune monitors for the two-ring PEP-II collider convert signals from one set of four BPM-type pickup buttons per ring into horizontal and vertical differences, which are then downconverted from 952 MHz (twice the RF) to baseband. Two-channel 10-MHz FFT spectrum analyzers show spectra in X-window displays in the Control Room, to assist PEP operators. When operating with the original system near the beam-beam limit, collisions broadened and flattened the tune peaks, often bringing them near the noise floor. We recently installed new downconverters that increase the signal-to-noise ratio by about 5 dB. In addition, we went from one to two sets of pickups per ring, near focusing and defocusing quadrupoles, so that signals for both planes originate at locations with large amplitudes. We also have just installed a tune tracker, based on a digital lock-in amplifier (one per tune plane) that is controlled by an EPICS software feedback loop. The tracker monitors the phase of the beam's response to a sinusoidal excitation, and adjusts the drive frequency to track the middle of the 1 go-degree phase transition across the tune resonance. We plan next to test an outer loop controlling the tune quadrupoles based on this tune measurement.

  20. Upgrades to PEP-II Tune Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Alan S.

    2002-07-30

    The tune monitors for the two-ring PEP-II collider convert signals from one set of four BPM-type pickup buttons per ring into horizontal and vertical differences, which are then downconverted from 952 MHz (twice the RF) to baseband. Two-channel l0-MHz FFT spectrum analyzers show spectra in X-window displays in the Control Room, to assist PEP operators. When operating with the original system near the beam-beam limit, collisions broadened and flattened the tune peaks, often bringing them near the noise floor. We recently installed new downconverters that increase the signal-to-noise ratio by about 5 dB. In addition, we went from one to two sets of pickups per ring, near focusing and defocusing quadrupoles, so that signals for both planes originate at locations with large amplitudes. We also have just installed a tune tracker, based on a digital lock-in amplifier (one per tune plane) that is controlled by an EPICS software feedback loop. The tracker monitors the phase of the beam's response to a sinusoidal excitation, and adjusts the drive frequency to track the middle of the 180-degree phase transition across the tune resonance. We plan next to test an outer loop controlling the tune quadrupoles based on this tune measurement.

  1. Upgrades to PEP-II tune measurements

    International Nuclear Information System (INIS)

    Fisher, Alan S.; Petree, Mark; Wienands, Uli; Allison, Stephanie; Laznovsky, Michael; Seeman, Michael; Robin, Jolene

    2002-01-01

    The tune monitors for the two-ring PEP-II collider convert signals from one set of four BPM-type pickup buttons per ring into horizontal and vertical differences, which are then downconverted from 952 MHz (twice the RF) to baseband. Two-channel 10-MHz FFT spectrum analyzers show spectra in X-window displays in the Control Room, to assist PEP operators. When operating with the original system near the beam-beam limit, collisions broadened and flattened the tune peaks, often bringing them near the noise floor. We recently installed new downconverters that increase the signal-to-noise ratio by about 5 dB. In addition, we went from one to two sets of pickups per ring, near focusing and defocusing quadrupoles, so that signals for both planes originate at locations with large amplitudes. We also have just installed a tune tracker, based on a digital lock-in amplifier (one per tune plane) that is controlled by an EPICS software feedback loop. The tracker monitors the phase of the beam's response to a sinusoidal excitation, and adjusts the drive frequency to track the middle of the 180-degree phase transition across the tune resonance. We plan next to test an outer loop controlling the tune quadrupoles based on this tune measurement

  2. Parametric system studies of candidate TF coil system options for the Tokamak Fusion Core Experiment (TFCX)

    International Nuclear Information System (INIS)

    Reiersen, W.T.; Flanagan, C.A.; Miller, J.B.

    1983-01-01

    System studies were performed to determine the sensitivity of hybrid and superconducting toroidal field (TF) coil system options to maximum field at the TF coil and to field enhancement due to resistive insert coils. The studies were performed using Tokamak Fusion Core Experiment (TFCX) design assumptions, guidelines, and criteria and involved iterative execution of the Fusion Engineering Design Center (FEDC) systems code, magnetohydrodynamics (MHD) equilibrium code, and EFFI (a code to evaluate magnetic field strength). The results indicate that for TFCX with no minimum wall loading specified, a design point chosen solely on the basis of cost would likely be in the low-field region of design space where the cost advantage of hybrids is least apparent. However, as the desired neutron wall loading increases, the hybrid option suggests an increasing cost advantage over the all-superconducting option; this cost advantage is countered by increased complexity in design -- particularly in assembly and maintenance

  3. Parametric system studies of candidate TF coil system options for the Tokamak Fusion Core Experiment (TFCX)

    International Nuclear Information System (INIS)

    Reiersen, W.T.; Flanagan, C.A.; Miller, J.B.

    1983-01-01

    System studies were performed to determine the sensitivity of hybrid and superconducting toroidal field (TF) coil system options to maximum field at the TF coil and to field enhancement due to resistive insert coils. The studies were performed using Tokamak Fusion Core Experiment (TFCX) design assumptions, guidelines, and criteria and involved iterative execution of the Fusion Engineering Design Center (FEDC) systems code, magnetohydrodynamics (MHD) equilibrium code, and EFFI (a code to evaluate magnetic field strength). The results indicate that for TFCX with no minimum wall loading specified, a design point chosen solely on the basis of cost would likely be in the low-field region of design space where the cost advantage of hybrids is least apparent. However, as the desired neutron wall loading increases, the hybrid option suggests an increasing cost advantage over the all-superconducting option; this cost advantage is countered by increased complexity in design - particularly in assembly and maintenance

  4. Analysis and tests of TF magnet insulation samples for the JET upgrade to 4 tesla

    CERN Document Server

    Miele, P; Bettinali, L; Kaye, A; Last, J; Papastergiou, S; Riccardo, V; Visca, E

    2000-01-01

    The JET Toroidal Field (TF) coils were originally designed for operation at 3.4 tesla. In order to upgrade the field to 4 tesla and thus improve the performance of the JET machine, new mechanical tests and analysis were carried out on the insulation of TF coil samples. They are aimed at investigating the mechanical properties and the status of the insulation in order to set allowable stresses and force limits. In particular since the shear stress in the insulation is strongly affected by the shear modulus of elasticity G, it is important to measure this parameter. A method for the measurement of G in glass-resin fibres, the V-notched beam method (Iosipescu method) , was applied. The particular shape of the rectangular Iosipescu V- notched sample and the particular modality of force application produce pure shear stress for a reliable measurement of the G value and of the shear strength of the insulation. The effect of temperature on these mechanical properties was also investigated. Results show higher averag...

  5. Enlargement of Tuning Range in a Ferrite-Tuned Cavity Through Superposed Orthogonal and Parallel Magnetic Bias

    CERN Document Server

    Vollinger, C

    2013-01-01

    Conventional ferrite-tuned cavities operate either with bias fields that are orthogonal or parallel to the magnetic RF-field. For a cavity that tunes rapidly over an overall frequency range around 100-400 MHz with high Q, we use ferrite garnets exposed to an innovative new biasing method consisting of a superposition of perpendicular and parallel magnetic fields. This method leads to a significant enlargement of the high-Q cavity tuning range by defining an operation point close to the magnetic saturation and thus improving ferrite material behaviour. A further advantage of this technique is the fast tuning speed resulting from the fact that tuning is carried out either with pure parallel biasing, or together with a very small change of operating point from perpendicular bias. In this paper, several scaled test models of ferrite-filled resonators are shown; measurements on the set-ups are compared and discussed.

  6. Automatic tuning of free electron lasers

    Energy Technology Data Exchange (ETDEWEB)

    Agapov, Ilya; Zagorodnov, Igor [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Geloni, Gianluca [European XFEL, Schenefeld (Germany); Tomin, Sergey [European XFEL, Schenefeld (Germany); NRC Kurchatov Institute, Moscow (Russian Federation)

    2017-04-07

    Existing FEL facilities often suffer from stability issues: so electron orbit, transverse electron optics, electron bunch compression and other parameters have to be readjusted often to account for drifts in performance of various components. The tuning procedures typically employed in operation are often manual and lengthy. We have been developing a combination of model-free and model-based automatic tuning methods to meet the needs of present and upcoming XFEL facilities. Our approach has been implemented at FLASH to achieve automatic SASE tuning using empirical control of orbit, electron optics and bunch compression. In this paper we describe our approach to empirical tuning, the software which implements it, and the results of using it at FLASH.We also discuss the potential of using machine learning and model-based techniques in tuning methods.

  7. Automatic tuning of free electron lasers

    International Nuclear Information System (INIS)

    Agapov, Ilya; Zagorodnov, Igor; Geloni, Gianluca; Tomin, Sergey

    2017-01-01

    Existing FEL facilities often suffer from stability issues: so electron orbit, transverse electron optics, electron bunch compression and other parameters have to be readjusted often to account for drifts in performance of various components. The tuning procedures typically employed in operation are often manual and lengthy. We have been developing a combination of model-free and model-based automatic tuning methods to meet the needs of present and upcoming XFEL facilities. Our approach has been implemented at FLASH to achieve automatic SASE tuning using empirical control of orbit, electron optics and bunch compression. In this paper we describe our approach to empirical tuning, the software which implements it, and the results of using it at FLASH.We also discuss the potential of using machine learning and model-based techniques in tuning methods.

  8. W-curve alignments for HIV-1 genomic comparisons.

    Directory of Open Access Journals (Sweden)

    Douglas J Cork

    2010-06-01

    Full Text Available The W-curve was originally developed as a graphical visualization technique for viewing DNA and RNA sequences. Its ability to render features of DNA also makes it suitable for computational studies. Its main advantage in this area is utilizing a single-pass algorithm for comparing the sequences. Avoiding recursion during sequence alignments offers advantages for speed and in-process resources. The graphical technique also allows for multiple models of comparison to be used depending on the nucleotide patterns embedded in similar whole genomic sequences. The W-curve approach allows us to compare large numbers of samples quickly.We are currently tuning the algorithm to accommodate quirks specific to HIV-1 genomic sequences so that it can be used to aid in diagnostic and vaccine efforts. Tracking the molecular evolution of the virus has been greatly hampered by gap associated problems predominantly embedded within the envelope gene of the virus. Gaps and hypermutation of the virus slow conventional string based alignments of the whole genome. This paper describes the W-curve algorithm itself, and how we have adapted it for comparison of similar HIV-1 genomes. A treebuilding method is developed with the W-curve that utilizes a novel Cylindrical Coordinate distance method and gap analysis method. HIV-1 C2-V5 env sequence regions from a Mother/Infant cohort study are used in the comparison.The output distance matrix and neighbor results produced by the W-curve are functionally equivalent to those from Clustal for C2-V5 sequences in the mother/infant pairs infected with CRF01_AE.Significant potential exists for utilizing this method in place of conventional string based alignment of HIV-1 genomes, such as Clustal X. With W-curve heuristic alignment, it may be possible to obtain clinically useful results in a short time-short enough to affect clinical choices for acute treatment. A description of the W-curve generation process, including a comparison

  9. W-curve alignments for HIV-1 genomic comparisons.

    Science.gov (United States)

    Cork, Douglas J; Lembark, Steven; Tovanabutra, Sodsai; Robb, Merlin L; Kim, Jerome H

    2010-06-01

    The W-curve was originally developed as a graphical visualization technique for viewing DNA and RNA sequences. Its ability to render features of DNA also makes it suitable for computational studies. Its main advantage in this area is utilizing a single-pass algorithm for comparing the sequences. Avoiding recursion during sequence alignments offers advantages for speed and in-process resources. The graphical technique also allows for multiple models of comparison to be used depending on the nucleotide patterns embedded in similar whole genomic sequences. The W-curve approach allows us to compare large numbers of samples quickly. We are currently tuning the algorithm to accommodate quirks specific to HIV-1 genomic sequences so that it can be used to aid in diagnostic and vaccine efforts. Tracking the molecular evolution of the virus has been greatly hampered by gap associated problems predominantly embedded within the envelope gene of the virus. Gaps and hypermutation of the virus slow conventional string based alignments of the whole genome. This paper describes the W-curve algorithm itself, and how we have adapted it for comparison of similar HIV-1 genomes. A treebuilding method is developed with the W-curve that utilizes a novel Cylindrical Coordinate distance method and gap analysis method. HIV-1 C2-V5 env sequence regions from a Mother/Infant cohort study are used in the comparison. The output distance matrix and neighbor results produced by the W-curve are functionally equivalent to those from Clustal for C2-V5 sequences in the mother/infant pairs infected with CRF01_AE. Significant potential exists for utilizing this method in place of conventional string based alignment of HIV-1 genomes, such as Clustal X. With W-curve heuristic alignment, it may be possible to obtain clinically useful results in a short time-short enough to affect clinical choices for acute treatment. A description of the W-curve generation process, including a comparison technique of

  10. Electromagnetic and structural global model of the TF magnet system in ASDEX Upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Zammuto, I., E-mail: irene.zammuto@ipp.mpg.de [Max-Planck-Institut für Plasmaphysik, EURATOM Association, D-85740 Garching (Germany); Streibl, B.; Giannone, L.; Herrmann, A.; Kallenbach, A.; Mertens, V. [Max-Planck-Institut für Plasmaphysik, EURATOM Association, D-85740 Garching (Germany)

    2013-10-15

    Highlights: ► An electromagnetic and structural FE 3D model is set up for ASDEX Upgrade. ► The model is benchmarked against the old design results, present displacement measurements. ► The benchmarked model is applied to the present plasma configurations, which have a different poloidal field distribution with respect to the design case. ► The different poloidal field influences the out-of-plane force distribution, thus requiring an update of the TF safety system. -- Abstract: The enhancements carried out in the tokamak ASDEX Upgrade (AUG) are oriented toward the preparation of the future physics-related activities of ITER and DEMO. To address the main ITER issues, plasma configurations with a wider operational limit (e.g. higher triangularity) are planned for the future experimental campaigns in AUG. To evaluate the mechanical impact on the toroidal field (TF) magnet system a combined electromagnetic and structural finite element model was set up. At first extensive benchmarks of the models are carried out against the AUG reference design configurations with respect to stress [1–3], lateral displacement measurements and poloidal flux pattern. The numerical model was then applied to a set of actual high triangularity (HT) configurations generated by a more favorable poloidal field (PF) current distribution made possible by an extension of the power supply system. The resulting change of the poloidal flux pattern and the lateral force distribution has consequences for the coil shear stress and vault stability. Both aspects are monitored by a safety system measuring the PF flux placed on top and bottom of the outer surface of two TF coils (TFCs) between vault and the TFC supporting structure, so called Turn Over Structure (TOS). The range of the new HT configurations has induced a modification of the flux pattern, so that an adaptation of safety system is required to protect the TFCs system. Following the same criteria of the old safety system [4,5], a new

  11. Association study between four polymorphisms in the HFE, TF and TFR genes and Parkinson's disease in southern Italy.

    Science.gov (United States)

    Greco, Valentina; De Marco, Elvira Valeria; Rocca, Francesca Emanuela; Annesi, Ferdinanda; Civitelli, Donatella; Provenzano, Giovanni; Tarantino, Patrizia; Scornaienchi, Vittorio; Pucci, Franco; Salsone, Maria; Novellino, Fabiana; Morelli, Maurizio; Paglionico, Sandra; Gambardella, Antonio; Quattrone, Aldo; Annesi, Grazia

    2011-06-01

    Iron overload may lead to neurodegenerative disorders such as Parkinson's disease (PD) and alterations of iron-related genes might be involved in the pathogenesis of this disease. The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF). We examined four known polymorphisms, C282Y and H63D in the HFE gene, G258S in the TF gene and S82G in the TFR gene, in 181 sporadic PD patients and 180 controls from Southern Italy to investigate their possible role in susceptibility to PD. No significant differences were found in genotype and allele frequencies between PD and controls for all the polymorphisms studied, suggesting that these variants do not contribute significantly to the risk of PD.

  12. Model-independent particle accelerator tuning

    Directory of Open Access Journals (Sweden)

    Alexander Scheinker

    2013-10-01

    Full Text Available We present a new model-independent dynamic feedback technique, rotation rate tuning, for automatically and simultaneously tuning coupled components of uncertain, complex systems. The main advantages of the method are: (1 it has the ability to handle unknown, time-varying systems, (2 it gives known bounds on parameter update rates, (3 we give an analytic proof of its convergence and its stability, and (4 it has a simple digital implementation through a control system such as the experimental physics and industrial control system (EPICS. Because this technique is model independent it may be useful as a real-time, in-hardware, feedback-based optimization scheme for uncertain and time-varying systems. In particular, it is robust enough to handle uncertainty due to coupling, thermal cycling, misalignments, and manufacturing imperfections. As a result, it may be used as a fine-tuning supplement for existing accelerator tuning/control schemes. We present multiparticle simulation results demonstrating the scheme’s ability to simultaneously adaptively adjust the set points of 22 quadrupole magnets and two rf buncher cavities in the Los Alamos Neutron Science Center (LANSCE Linear Accelerator’s transport region, while the beam properties and rf phase shift are continuously varying. The tuning is based only on beam current readings, without knowledge of particle dynamics. We also present an outline of how to implement this general scheme in software for optimization, and in hardware for feedback-based control/tuning, for a wide range of systems.

  13. Conference on heat mass transfer and properties of liquid metals TF-2002

    International Nuclear Information System (INIS)

    Efanov, A.D.; Kozlov, F.A.

    2003-01-01

    Results of the conference TF-2002 devoted to the combined approach to problems of harnessing liquid metals as coolants for NPU are presented. The conference takes place in Obninsk, 29 - 31 October, 2002. Papers of the conference involve items on thermal hydraulics, mass transfer and safety of NPU with liquid metal coolants, structure, physical and chemical properties of liquid metal and liquid metal solutions, decommissioning of units and ecology, application of liquid metals divorced with NPU. Most of the papers of the conference are devoted to the investigation into lead and lead-bismuth coolants [ru

  14. GENIUS-TF - a test facility for the GENIUS project. Proposal

    International Nuclear Information System (INIS)

    Klapdor-Kleingrothaus, H.V.; Dietz, A.; Heusser, G.

    2001-02-01

    GENIUS is a proposal for a large scale detector of rare events. As a first step of the experiment, a small test version, the Genius Test-Facility is proposed to be built up at the Laboratori Nazionali del Gran Sasso (LNGS). With about 40 kg of natural Ge detectors operated in liquid nitrogen, Genius-TF could exclude (or directly confirm) the DAMA annual modulation signature within about two years of measurement using both, signal and signature of the claimed WIMP Dark matter. The funding of the experiment has already been approved and four 2.5 kg germanium detectors with an extreme low treshold of 500 eV have been produced. The installation can be started immediately. No additional space in the Underground Laboratory is required. (orig.)

  15. Control of Fermilab Booster tunes

    International Nuclear Information System (INIS)

    Johnson, R.P; Meisner, K.; Sandberg, B.

    1977-01-01

    Control of the radial and vertical tunes of the booster is implemented using ramped correction quadrupoles. Minor modifications to the power supply cards for the 48 (previously) dc correction quadrupoles allow ''the tunes'' to be continuously programmed or held constant throughout the 33 ms acceleration cycle. This capability is in addition to the usual use of these quadrupoles to be independently varied to correct for harmonic distortions in the lattice. An automatic computer program measures and displays the tunes vs. time in the cycle to monitor performance and to allow the ramps to be adjusted by the machine operator

  16. Implementation of non-condensable gases condensation suppression model into the WCOBRA/TRAC-TF2 LOCA safety evaluation code

    Energy Technology Data Exchange (ETDEWEB)

    Liao, J.; Cao, L.; Ohkawa, K.; Frepoli, C. [LOCA Integrated Services I, Westinghouse Electric Company, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

    2012-07-01

    The non-condensable gases condensation suppression model is important for a realistic LOCA safety analysis code. A condensation suppression model for direct contact condensation was previously developed by Westinghouse using first principles. The model is believed to be an accurate description of the direct contact condensation process in the presence of non-condensable gases. The Westinghouse condensation suppression model is further revised by applying a more physical model. The revised condensation suppression model is thus implemented into the WCOBRA/TRAC-TF2 LOCA safety evaluation code for both 3-D module (COBRA-TF) and 1-D module (TRAC-PF1). Parametric study using the revised Westinghouse condensation suppression model is conducted. Additionally, the performance of non-condensable gases condensation suppression model is examined in the ACHILLES (ISP-25) separate effects test and LOFT L2-5 (ISP-13) integral effects test. (authors)

  17. Fusion of Potentiometric & Voltammetric Electronic Tongue for Classification of Black Tea Taste based on Theaflavins (TF) Content

    Science.gov (United States)

    Bhattacharyya, Nabarun; Legin, Andrey; Papieva, Irina; Sarkar, Subrata; Kirsanov, Dmitry; Kartsova, Anna; Ghosh, Arunangshu; Bandyopadhyay, Rajib

    2011-09-01

    Black tea is an extensively consumed beverage worldwide with an expanding market. The final quality of black tea depends upon number of chemical compounds present in the tea. Out of these compounds, theaflavins (TF), which is responsible for astringency in black tea, plays an important role in determining the final taste of the finished black tea. The present paper reports our effort to correlate the theaflavins contents with the voltammetric and potentiometric electronic tongue (e-tongue) data. Noble metal-based electrode array has been used for collecting data though voltammetric electronic tongue where as liquid filled membrane based electrodes have been used for potentiometric electronic tongue. Black tea samples with tea taster score and biochemical results have been collected from Tea Research Association, Tocklai, India for the analysis purpose. In this paper, voltammetric and potentiometric e-tongue responses are combined to demonstrate improvement of cluster formation among tea samples with different ranges of TF values.

  18. Widespread auditory deficits in tune deafness.

    Science.gov (United States)

    Jones, Jennifer L; Zalewski, Christopher; Brewer, Carmen; Lucker, Jay; Drayna, Dennis

    2009-02-01

    The goal of this study was to investigate auditory function in individuals with deficits in musical pitch perception. We hypothesized that such individuals have deficits in nonspeech areas of auditory processing. We screened 865 randomly selected individuals to identify those who scored poorly on the Distorted Tunes test (DTT), a measure of musical pitch recognition ability. Those who scored poorly were given a comprehensive audiologic examination, and those with hearing loss or other confounding audiologic factors were excluded from further testing. Thirty-five individuals with tune deafness constituted the experimental group. Thirty-four individuals with normal hearing and normal DTT scores, matched for age, gender, handedness, and education, and without overt or reported psychiatric disorders made up the normal control group. Individual and group performance for pure-tone frequency discrimination at 1000 Hz was determined by measuring the difference limen for frequency (DLF). Auditory processing abilities were assessed using tests of pitch pattern recognition, duration pattern recognition, and auditory gap detection. In addition, we evaluated both attention and short- and long-term memory as variables that might influence performance on our experimental measures. Differences between groups were evaluated statistically using Wilcoxon nonparametric tests and t-tests as appropriate. The DLF at 1000 Hz in the group with tune deafness was significantly larger than that of the normal control group. However, approximately one-third of participants with tune deafness had DLFs within the range of performance observed in the control group. Many individuals with tune deafness also displayed a high degree of variability in their intertrial frequency discrimination performance that could not be explained by deficits in memory or attention. Pitch and duration pattern discrimination and auditory gap-detection ability were significantly poorer in the group with tune deafness

  19. Tune splitting in the presence of linear coupling

    International Nuclear Information System (INIS)

    Parzen, G.

    1991-01-01

    The presence of random skew quadrupole field errors will couple the x and y motions. The x and y motions are then each given by the sum of 2 normal modes with the tunes v 1 and v 2 , which may differ appreciably from v x and v y , the unperturbed tunes. This is often called tune splitting since |v 1 - v 2 | is usually larger than |v x - v y |. This tune splitting may be large in proton accelerators using superconducting magnets, because of the relatively large random skew quadrupole field errors that are expected in these magnets. This effect is also increased by the required insertions in proton colliders which generate large β-functions in the insertion region. This tune splitting has been studied in the RHIC accelerator. For RHIC, a tune splitting as large as 0.2 was found in one worse case. A correction system has been developed for correcting this large tune splitting which uses two families of skew quadrupole correctors. It has been found that this correction system corrects most of the large tune splitting, but a residual tune splitting remains that is still appreciable. This paper discusses the corrections to this residual time

  20. Qualification tests for ITER TF conductors in SULTAN

    International Nuclear Information System (INIS)

    Bruzzone, P.; Stepanov, B.; Wesche, R.

    2009-01-01

    From February 2007 to May 2008, 18 short length conductor sections have been tested in SULTAN for design verification and manufacturer qualification of the ITER Toroidal Field (TF) conductor. The test program is focussed on the current sharing temperature, T cs , at the nominal operating conditions, 68 kA current and 11.15 T effective field, which can be fully reproduced in the SULTAN test facility. A broad range of results was observed, with over 2 K difference among the T cs of the conductors. In average, the results are poorer compared to the potential performance estimated from the strand scaling law. The key parameters to mitigate the degradation are not yet clearly identified. The experimental challenges to test conductors with performance degradation are highlighted, including enhanced instrumentation sets, the application of gas flow calorimetry to sense the current sharing power and the post-processing of voltage data to cancel the transverse potential across the cable. The updated schedule of the tests in SULTAN is presented with the short-term action plan for conductor test.

  1. APT Blanket Detailed Bin Model Based on Initial Plate-Type Design -3D FLOWTRAN-TF Model

    International Nuclear Information System (INIS)

    Hamm, L.L.

    1998-01-01

    This report provides background information for a series of reports documenting accident scenario simulations for the Accelerator Production of Tritium (APT) blanket heat removal systems. The simulations were performed in support of the Preliminary Safety Analysis Report for the APT. This report gives a brief description of the FLOWTRAN-TF code which was used for detailed blanket bin modeling

  2. Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR)

    DEFF Research Database (Denmark)

    Christensen, Anders; Kiss, Katalin; Lelkaitis, Giedrius

    2017-01-01

    Background: Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhib...... with a reduced survival. uPAR seems to be a prognostic biomarker in oral cancer....

  3. Optimal Self-Tuning PID Controller Based on Low Power Consumption for a Server Fan Cooling System.

    Science.gov (United States)

    Lee, Chengming; Chen, Rongshun

    2015-05-20

    Recently, saving the cooling power in servers by controlling the fan speed has attracted considerable attention because of the increasing demand for high-density servers. This paper presents an optimal self-tuning proportional-integral-derivative (PID) controller, combining a PID neural network (PIDNN) with fan-power-based optimization in the transient-state temperature response in the time domain, for a server fan cooling system. Because the thermal model of the cooling system is nonlinear and complex, a server mockup system simulating a 1U rack server was constructed and a fan power model was created using a third-order nonlinear curve fit to determine the cooling power consumption by the fan speed control. PIDNN with a time domain criterion is used to tune all online and optimized PID gains. The proposed controller was validated through experiments of step response when the server operated from the low to high power state. The results show that up to 14% of a server's fan cooling power can be saved if the fan control permits a slight temperature response overshoot in the electronic components, which may provide a time-saving strategy for tuning the PID controller to control the server fan speed during low fan power consumption.

  4. Optimal Self-Tuning PID Controller Based on Low Power Consumption for a Server Fan Cooling System

    Directory of Open Access Journals (Sweden)

    Chengming Lee

    2015-05-01

    Full Text Available Recently, saving the cooling power in servers by controlling the fan speed has attracted considerable attention because of the increasing demand for high-density servers. This paper presents an optimal self-tuning proportional-integral-derivative (PID controller, combining a PID neural network (PIDNN with fan-power-based optimization in the transient-state temperature response in the time domain, for a server fan cooling system. Because the thermal model of the cooling system is nonlinear and complex, a server mockup system simulating a 1U rack server was constructed and a fan power model was created using a third-order nonlinear curve fit to determine the cooling power consumption by the fan speed control. PIDNN with a time domain criterion is used to tune all online and optimized PID gains. The proposed controller was validated through experiments of step response when the server operated from the low to high power state. The results show that up to 14% of a server’s fan cooling power can be saved if the fan control permits a slight temperature response overshoot in the electronic components, which may provide a time-saving strategy for tuning the PID controller to control the server fan speed during low fan power consumption.

  5. Telling in-tune from out-of-tune: widespread evidence for implicit absolute intonation.

    Science.gov (United States)

    Van Hedger, Stephen C; Heald, Shannon L M; Huang, Alex; Rutstein, Brooke; Nusbaum, Howard C

    2017-04-01

    Absolute pitch (AP) is the rare ability to name or produce an isolated musical note without the aid of a reference note. One skill thought to be unique to AP possessors is the ability to provide absolute intonation judgments (e.g., classifying an isolated note as "in-tune" or "out-of-tune"). Recent work has suggested that absolute intonation perception among AP possessors is not crystallized in a critical period of development, but is dynamically maintained by the listening environment, in which the vast majority of Western music is tuned to a specific cultural standard. Given that all listeners of Western music are constantly exposed to this specific cultural tuning standard, our experiments address whether absolute intonation perception extends beyond AP possessors. We demonstrate that non-AP listeners are able to accurately judge the intonation of completely isolated notes. Both musicians and nonmusicians showed evidence for absolute intonation recognition when listening to familiar timbres (piano and violin). When testing unfamiliar timbres (triangle and inverted sine waves), only musicians showed weak evidence of absolute intonation recognition (Experiment 2). Overall, these results highlight a previously unknown similarity between AP and non-AP possessors' long-term musical note representations, including evidence of sensitivity to frequency.

  6. Quickly Planning TF/TA2 Trajectory by Artificial Immune Algorithm

    Directory of Open Access Journals (Sweden)

    LIU Lifeng

    2015-04-01

    Full Text Available Flight path planning by artificial immune algorithm approach met the requirements of aircraft's flyability and operation is proposed for the problem of single and double TF/TA2 flight path planning. Punishment function (affinity function with comprehensive 3D threat information is designed. A comprehensive threat model is formed including dynamic and static threats and no-fly-zone. Accordingly, single and dual flight paths are planned by AIA, which have been compared with the paths by GA. The results show that, GA's planned a quick and longer path compared under simple threat environment; in complex environments, GA has high failure rate (greater than 95% for single aircraft, but it is failed for double aircrafts. For the single and double aircrafts, AIA can provides one optimal and more candidate optimal flight paths.

  7. EU ITER TF coil: Dimensional metrology, a key player in the Double Pancake integration

    International Nuclear Information System (INIS)

    Poncet, L.; Bellesia, B.; Oliva, A. Bonito; Boter Rebollo, E.; Cornelis, M.; Cornella Medrano, J.; Harrison, R.; Bue, A. Lo; Moreno, A.; Foussat, A.; Felipe, A.; Echeandia, A.; Barutti, A.; Caserza, B.; Barbero, P.; Stenca, S.; Da Re, A.; Silva Ribeiro, J.; Brocot, C.; Benaoun, S.

    2015-01-01

    Highlights: • Development and qualification of a dimensional metrology procedure on wound superconductor trajectory based on Laser scanning system. • Dimensional control of the conductor centreline during winding, before and after heat treatment. • Radial Plate groove centreline length controlled using Laser Trackers. • Full scale wound Double Pancake prototype transferred inside Radial Plate prototype without any issues. - Abstract: The ITER Toroidal Field (TF) magnet system consists of 18 “D” shaped coils. Fusion for Energy (F4E), the European Domestic Agency for ITER, is responsible for the supply of 10 out the 19 TF coils (18 installed plus one spare coil). Each TF coil, about 300 t in weight, is made of a stainless steel case containing a Winding Pack (WP). The European manufacturing of the Radial Plates (RPs) and WPs has been awarded to two different industrial partners, whose activities are strongly linked with each other. In order to manufacture a Double Pancake (DP), first, the conductor has to be bent onto a D-shaped double spiral trajectory, then heat treated and inserted in the grooves of the RP. This represents the most challenging manufacturing step: in order to fit inside the groove, the double spiral trajectory of the conductor must match almost perfectly the trajectory of the groove, over a length above 700 m. In order to achieve this, the conductor trajectory length must be controlled with an accuracy of 1 mm over a length of 350 m while the radial plate groove has to be machined with tolerances of ±0.2 mm over dimensions of more than 10 m. In order to succeed, it has been essential to develop a metrology process capable to control with high accuracy both the DP conductor and the RP groove trajectories. This paper reports on the work carried out on the development and qualification of the dimensional metrology to monitor the manufacturing of the conductor. Reference is made to the final dimensional check of the RP focusing on the

  8. Identifying Cancer Subtypes from miRNA-TF-mRNA Regulatory Networks and Expression Data.

    Directory of Open Access Journals (Sweden)

    Taosheng Xu

    Full Text Available Identifying cancer subtypes is an important component of the personalised medicine framework. An increasing number of computational methods have been developed to identify cancer subtypes. However, existing methods rarely use information from gene regulatory networks to facilitate the subtype identification. It is widely accepted that gene regulatory networks play crucial roles in understanding the mechanisms of diseases. Different cancer subtypes are likely caused by different regulatory mechanisms. Therefore, there are great opportunities for developing methods that can utilise network information in identifying cancer subtypes.In this paper, we propose a method, weighted similarity network fusion (WSNF, to utilise the information in the complex miRNA-TF-mRNA regulatory network in identifying cancer subtypes. We firstly build the regulatory network where the nodes represent the features, i.e. the microRNAs (miRNAs, transcription factors (TFs and messenger RNAs (mRNAs and the edges indicate the interactions between the features. The interactions are retrieved from various interatomic databases. We then use the network information and the expression data of the miRNAs, TFs and mRNAs to calculate the weight of the features, representing the level of importance of the features. The feature weight is then integrated into a network fusion approach to cluster the samples (patients and thus to identify cancer subtypes. We applied our method to the TCGA breast invasive carcinoma (BRCA and glioblastoma multiforme (GBM datasets. The experimental results show that WSNF performs better than the other commonly used computational methods, and the information from miRNA-TF-mRNA regulatory network contributes to the performance improvement. The WSNF method successfully identified five breast cancer subtypes and three GBM subtypes which show significantly different survival patterns. We observed that the expression patterns of the features in some miRNA-TF

  9. Apple iTunes music store

    OpenAIRE

    Lenzi, R.; Schmucker, M.; Spadoni, F.

    2003-01-01

    This technical report analyses the Apple iTunes Music Store and its success factors. Besides the technical aspects, user and customer aspects as well as content aspects are considered. Furthermore, iTunes Music Store's impact to online music distribution services is analysed and a short outlook to future music online distribution is given.

  10. Lagrangian Curves on Spectral Curves of Monopoles

    International Nuclear Information System (INIS)

    Guilfoyle, Brendan; Khalid, Madeeha; Ramon Mari, Jose J.

    2010-01-01

    We study Lagrangian points on smooth holomorphic curves in TP 1 equipped with a natural neutral Kaehler structure, and prove that they must form real curves. By virtue of the identification of TP 1 with the space LE 3 of oriented affine lines in Euclidean 3-space, these Lagrangian curves give rise to ruled surfaces in E 3 , which we prove have zero Gauss curvature. Each ruled surface is shown to be the tangent lines to a curve in E 3 , called the edge of regression of the ruled surface. We give an alternative characterization of these curves as the points in E 3 where the number of oriented lines in the complex curve Σ that pass through the point is less than the degree of Σ. We then apply these results to the spectral curves of certain monopoles and construct the ruled surfaces and edges of regression generated by the Lagrangian curves.

  11. Small-angle neutron scattering from the reconstituted TF sub 1 of H sup + -ATPase from thermophilic bacterium PS3 with deuterated subunits

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Yuji [Univ. of Tokyo (Japan) Brookhaven National Lab., Upton, NY (United States); Harada, Mitsuo [Univ. of Tokyo (Japan); Ohta, Shigeo; Kagawa, Yasuo; Aono, Osamu [Jichi Medical School, Tochigi (Japan); Schefer, J; Schoenborn, B P [Brookhaven National Lab., Upton (United States)

    1990-01-01

    Subunits {alpha}, {beta} and {gamma} of adenosine triphosphatase (H{sup +}-ATPase) from the thermophilic bacterium PS3 (TF{sub 1}) have been over-expressed in Escherichia coli. {alpha} and {beta} subunits deuterated to the level of 90% were obtained by culturing E. coli in {sup 2}H{sub 2}O medium. Both the subunits and the reconstituted {alpha}{beta}{gamma} complex, TF{sub 1}, which contain the deuterated components in various combinations, were studied in solution by small-angle neutron scattering. The individual shapes of the subunits and their organization in the {alpha}{beta}{gamma}-TF{sub 1} complex were examined using the techniques of selective deuteration and contrast variation. The {alpha} and {beta} subunits are well approximated as ellipsoids of revolution having minor semi-axes of 20{center dot}4({plus minus}0{center dot}4) and 20{center dot}0({plus minus}0{center dot}2) {angstrom}, and major semi-axes of 53{center dot}0({plus minus}1{center dot}4) and 55{center dot}8({plus minus}0{center dot}9) {angstrom}, respectively. In the TF{sub 1} complex, three {beta} subunits are aligned to form an equilateral triangle, with their major axes tilted by 35{degree} with respect to the 3-fold axis of the complex. The {beta}-{beta} distance is about 53 {angstrom}. Three {alpha} subunits are similarly arranged, positioned between the {beta} subunits, and with their direction of tilt opposite to that of the {beta} subunits. The centers of the {alpha} and {beta} subunits lie in the same plane, forming a hexagon. Adjacent subunits overlap in this model, suggesting that they are not simple ellipsoids of revolution.

  12. The minimally tuned minimal supersymmetric standard model

    International Nuclear Information System (INIS)

    Essig, Rouven; Fortin, Jean-Francois

    2008-01-01

    The regions in the Minimal Supersymmetric Standard Model with the minimal amount of fine-tuning of electroweak symmetry breaking are presented for general messenger scale. No a priori relations among the soft supersymmetry breaking parameters are assumed and fine-tuning is minimized with respect to all the important parameters which affect electroweak symmetry breaking. The superpartner spectra in the minimally tuned region of parameter space are quite distinctive with large stop mixing at the low scale and negative squark soft masses at the high scale. The minimal amount of tuning increases enormously for a Higgs mass beyond roughly 120 GeV

  13. A conformal mapping based fractional order approach for sub-optimal tuning of PID controllers with guaranteed dominant pole placement

    Science.gov (United States)

    Saha, Suman; Das, Saptarshi; Das, Shantanu; Gupta, Amitava

    2012-09-01

    A novel conformal mapping based fractional order (FO) methodology is developed in this paper for tuning existing classical (Integer Order) Proportional Integral Derivative (PID) controllers especially for sluggish and oscillatory second order systems. The conventional pole placement tuning via Linear Quadratic Regulator (LQR) method is extended for open loop oscillatory systems as well. The locations of the open loop zeros of a fractional order PID (FOPID or PIλDμ) controller have been approximated in this paper vis-à-vis a LQR tuned conventional integer order PID controller, to achieve equivalent integer order PID control system. This approach eases the implementation of analog/digital realization of a FOPID controller with its integer order counterpart along with the advantages of fractional order controller preserved. It is shown here in the paper that decrease in the integro-differential operators of the FOPID/PIλDμ controller pushes the open loop zeros of the equivalent PID controller towards greater damping regions which gives a trajectory of the controller zeros and dominant closed loop poles. This trajectory is termed as "M-curve". This phenomena is used to design a two-stage tuning algorithm which reduces the existing PID controller's effort in a significant manner compared to that with a single stage LQR based pole placement method at a desired closed loop damping and frequency.

  14. Application of genetic algorithms to tuning fuzzy control systems

    Science.gov (United States)

    Espy, Todd; Vombrack, Endre; Aldridge, Jack

    1993-01-01

    Real number genetic algorithms (GA) were applied for tuning fuzzy membership functions of three controller applications. The first application is our 'Fuzzy Pong' demonstration, a controller that controls a very responsive system. The performance of the automatically tuned membership functions exceeded that of manually tuned membership functions both when the algorithm started with randomly generated functions and with the best manually-tuned functions. The second GA tunes input membership functions to achieve a specified control surface. The third application is a practical one, a motor controller for a printed circuit manufacturing system. The GA alters the positions and overlaps of the membership functions to accomplish the tuning. The applications, the real number GA approach, the fitness function and population parameters, and the performance improvements achieved are discussed. Directions for further research in tuning input and output membership functions and in tuning fuzzy rules are described.

  15. Revisiting fine-tuning in the MSSM

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Graham G. [Oxford Univ. (United Kingdom). Rudolf Peierls Centre for Theoretical Physics; Schmidt-Hoberg, Kai [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Staub, Florian [Karlsruher Institut fuer Technologie (KIT), Karlsruhe (Germany). Inst. fuer Theoretische Physik; Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Inst. fuer Experimentelle Kernphysik

    2017-03-15

    We evaluate the amount of fine-tuning in constrained versions of the minimal supersymmetric standard model (MSSM), with different boundary conditions at the GUT scale. Specifically we study the fully constrained version as well as the cases of non-universal Higgs and gaugino masses. We allow for the presence of additional non-holomorphic soft-terms which we show further relax the fine-tuning. Of particular importance is the possibility of a Higgsino mass term and we discuss possible origins for such a term in UV complete models. We point out that loop corrections typically lead to a reduction in the fine-tuning by a factor of about two compared to the estimate at tree-level, which has been overlooked in many recent works. Taking these loop corrections into account, we discuss the impact of current limits from SUSY searches and dark matter on the fine-tuning. Contrary to common lore, we find that the MSSM fine-tuning can be as small as 10 while remaining consistent with all experimental constraints. If, in addition, the dark matter abundance is fully explained by the neutralino LSP, the fine-tuning can still be as low as ∝20 in the presence of additional non-holomorphic soft-terms. We also discuss future prospects of these models and find that the MSSM will remain natural even in the case of a non-discovery in the foreseeable future.

  16. Revisiting fine-tuning in the MSSM

    Energy Technology Data Exchange (ETDEWEB)

    Ross, Graham G. [Rudolf Peierls Centre for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford OX1 3NP (United Kingdom); Schmidt-Hoberg, Kai [DESY, Notkestraße 85, D-22607 Hamburg (Germany); Staub, Florian [Institute for Theoretical Physics (ITP), Karlsruhe Institute of Technology, Engesserstraße 7, D-76128 Karlsruhe (Germany); Institute for Nuclear Physics (IKP), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)

    2017-03-06

    We evaluate the amount of fine-tuning in constrained versions of the minimal supersymmetric standard model (MSSM), with different boundary conditions at the GUT scale. Specifically we study the fully constrained version as well as the cases of non-universal Higgs and gaugino masses. We allow for the presence of additional non-holomorphic soft-terms which we show further relax the fine-tuning. Of particular importance is the possibility of a Higgsino mass term and we discuss possible origins for such a term in UV complete models. We point out that loop corrections typically lead to a reduction in the fine-tuning by a factor of about two compared to the estimate at tree-level, which has been overlooked in many recent works. Taking these loop corrections into account, we discuss the impact of current limits from SUSY searches and dark matter on the fine-tuning. Contrary to common lore, we find that the MSSM fine-tuning can be as small as 10 while remaining consistent with all experimental constraints. If, in addition, the dark matter abundance is fully explained by the neutralino LSP, the fine-tuning can still be as low as ∼20 in the presence of additional non-holomorphic soft-terms. We also discuss future prospects of these models and find that the MSSM will remain natural even in the case of a non-discovery in the foreseeable future.

  17. A mechanism for tuning 5 GHz HTS filters

    Energy Technology Data Exchange (ETDEWEB)

    Ohsaka, M.; Takeuchi, S.; Ono, S.; Lee, J.H.; Saito, A. [Department of Electrical Engineering, Yamagata University, 4-3-16 Johnan, Yonezawa 992-8510 (Japan); Akasegawa, A.; Yamanaka, K.; Kurihara, K. [Fujitsu LTD., 10-1 Wakamiya, Morinosato, Atsugi, Kanagawa 243-0197 (Japan); Ohshima, S. [Department of Electrical Engineering, Yamagata University, 4-3-16 Johnan, Yonezawa 992-8510 (Japan)], E-mail: ohshima@yz.yamagata-u.ac.jp

    2008-09-15

    We developed a tuning mechanism of HTS filter with a dielectric tuning plate, dielectric trimming rods, and conducting trimming rods. The tuning plate has windows through which the dielectric and conducting trimming rods pass. The tuning plate was designed for a 3-pole filter with 5 GHz center frequency (f{sub c}) and 100 MHz bandwidth (BW) using a 3-dimensional electromagnetic simulator. We were able to shift the f{sub c} to frequencies below 500 MHz using the tuning plate with a dielectric constant of 45. However, the insertion loss (IL) and the pass-band ripple of the filter became more severe and the BW of the filter was narrower after tuning. We tried to improve the filter properties after tuning using the dielectric and conducting trimming rods. We decreased the IL and the pass-band ripple by adjusting the height of the dielectric trimming rods to above the resonators. Also, the BW was improved by using copper (Cu) trimming rods above the spaces between the resonators. The tuning plate and the trimming rods did not affect the IL. So, we simulated 500 MHz tuning without the filter properties deteriorating at f{sub c} = 5 GHz. Also, we experimentally evaluated that the f{sub c} could be shifted to 340 MHz using the dielectric plate, the pass-band ripple could be decreased by ripple trimming using the dielectric rods, and the BW could be increased 31 MHz by BW trimming using the Cu rods.

  18. Summary of ATLAS Pythia 8 tunes

    CERN Document Server

    The ATLAS collaboration

    2012-01-01

    We summarize the latest ATLAS Pythia 8 minimum bias and underlying event tunes. The Pythia 8 MPI tunes in this note have been constructed for nine different PDFs, making use of a new x-dependent hadronic matter distribution model.

  19. Machine Learning Techniques for Stellar Light Curve Classification

    Science.gov (United States)

    Hinners, Trisha A.; Tat, Kevin; Thorp, Rachel

    2018-07-01

    We apply machine learning techniques in an attempt to predict and classify stellar properties from noisy and sparse time-series data. We preprocessed over 94 GB of Kepler light curves from the Mikulski Archive for Space Telescopes (MAST) to classify according to 10 distinct physical properties using both representation learning and feature engineering approaches. Studies using machine learning in the field have been primarily done on simulated data, making our study one of the first to use real light-curve data for machine learning approaches. We tuned our data using previous work with simulated data as a template and achieved mixed results between the two approaches. Representation learning using a long short-term memory recurrent neural network produced no successful predictions, but our work with feature engineering was successful for both classification and regression. In particular, we were able to achieve values for stellar density, stellar radius, and effective temperature with low error (∼2%–4%) and good accuracy (∼75%) for classifying the number of transits for a given star. The results show promise for improvement for both approaches upon using larger data sets with a larger minority class. This work has the potential to provide a foundation for future tools and techniques to aid in the analysis of astrophysical data.

  20. Impact of sodium butyrate and mild hypothermia on metabolic and physiological behaviour of CHO TF 70R cells

    Directory of Open Access Journals (Sweden)

    Veronica Avello

    2017-05-01

    Conclusions: The combination of NaBu addition and mild hypothermic condition causes an impact on physiological and metabolic state of CHO TF 70R cells, decreasing cell growth rate and improving glucose consumption efficiency. These results therefore provide a promising strategy to increase specific productivity of rh-tPA.

  1. Frequency Tuning of Vibration Absorber Using Topology Optimization

    Science.gov (United States)

    Harel, Swapnil Subhash

    A tuned mass absorber is a system for reducing the amplitude in one oscillator by coupling it to a second oscillator. If tuned correctly, the maximum amplitude of the first oscillator in response to a periodic driver will be lowered, and much of the vibration will be 'transferred' to the second oscillator. The tuned vibration absorber (TVA) has been utilized for vibration control purposes in many sectors of Civil/Automotive/Aerospace Engineering for many decades since its inception. Time and again we come across a situation in which a vibratory system is required to run near resonance. In the past, approaches have been made to design such auxiliary spring mass tuned absorbers for the safety of the structures. This research focuses on the development and optimization of continuously tuned mass absorbers as a substitute to the discretely tuned mass absorbers (spring- mass system). After conducting the study of structural behavior, the boundary condition and frequency to which the absorber is to be tuned are determined. The Modal analysis approach is used to determine mode shapes and frequencies. The absorber is designed and optimized using the topology optimization tool, which simultaneously designs, optimizes and tunes the absorber to the desired frequency. The tuned, optimized absorber, after post processing, is attached to the target structure. The number of the absorbers are increased to amplify bandwidth and thereby upgrade the safety of structure for a wide range of frequency. The frequency response analysis is carried out using various combinations of structure and number of absorber cell.

  2. Efficient tuning in supervised machine learning

    NARCIS (Netherlands)

    Koch, Patrick

    2013-01-01

    The tuning of learning algorithm parameters has become more and more important during the last years. With the fast growth of computational power and available memory databases have grown dramatically. This is very challenging for the tuning of parameters arising in machine learning, since the

  3. Dynamic Performance Tuning Supported by Program Specification

    Directory of Open Access Journals (Sweden)

    Eduardo César

    2002-01-01

    Full Text Available Performance analysis and tuning of parallel/distributed applications are very difficult tasks for non-expert programmers. It is necessary to provide tools that automatically carry out these tasks. These can be static tools that carry out the analysis on a post-mortem phase or can tune the application on the fly. Both kind of tools have their target applications. Static automatic analysis tools are suitable for stable application while dynamic tuning tools are more appropriate to applications with dynamic behaviour. In this paper, we describe KappaPi as an example of a static automatic performance analysis tool, and also a general environment based on parallel patterns for developing and dynamically tuning parallel/distributed applications.

  4. Solvent extraction of Pu(IV) with TODGA in C6mimTf2N

    International Nuclear Information System (INIS)

    Xiaohong Huang; Qiuyue Zhang; Jinping Liu; Hui He; Wenbin Zhu; Xiaorong Wang

    2013-01-01

    Studies on the solvent extraction of Plutonium(Pu(IV)) from aqueous nitric acid by N,N,N'N'tetraoctyl-diglycolamide (TODGA) in 1-hexyl-3-methylimidazolium-bis(trifluoromethylsulfonyl) imide (C 6 mimTf 2 N) room temperature ionic liquid (RTIL) were carried out. It was found that Pu(IV) is extracted into RTIL phase as [Pu(NO 3 )(TODGA)] 3+ through cation exchange mechanism. Extraction reaction equation is obtained by the influence of acidity and extractant concentration, and the parameters of thermodynamic equilibrium constant was calculated. (author)

  5. A tuning method for nonuniform traveling-wave accelerating structures

    International Nuclear Information System (INIS)

    Gong Cunkui; Zheng Shuxin; Shao Jiahang; Jia Xiaoyu; Chen Huaibi

    2013-01-01

    The tuning method of uniform traveling-wave structures based on non-resonant perturbation field distribution measurement has been widely used in tuning both constant-impedance and constant-gradient structures. In this paper, the method of tuning nonuniform structures is proposed on the basis of the above theory. The internal reflection coefficient of each cell is obtained from analyzing the normalized voltage distribution. A numerical simulation of tuning process according to the coupled cavity chain theory has been done and the result shows each cell is in right phase advance after tuning. The method will be used in the tuning of a disk-loaded traveling-wave structure being developed at the Accelerator Laboratory, Tsinghua University. (authors)

  6. An optimal tuning strategy for tidal turbines

    Science.gov (United States)

    2016-01-01

    Tuning wind and tidal turbines is critical to maximizing their power output. Adopting a wind turbine tuning strategy of maximizing the output at any given time is shown to be an extremely poor strategy for large arrays of tidal turbines in channels. This ‘impatient-tuning strategy’ results in far lower power output, much higher structural loads and greater environmental impacts due to flow reduction than an existing ‘patient-tuning strategy’ which maximizes the power output averaged over the tidal cycle. This paper presents a ‘smart patient tuning strategy’, which can increase array output by up to 35% over the existing strategy. This smart strategy forgoes some power generation early in the half tidal cycle in order to allow stronger flows to develop later in the cycle. It extracts enough power from these stronger flows to produce more power from the cycle as a whole than the existing strategy. Surprisingly, the smart strategy can often extract more power without increasing maximum structural loads on the turbines, while also maintaining stronger flows along the channel. This paper also shows that, counterintuitively, for some tuning strategies imposing a cap on turbine power output to limit loads can increase a turbine’s average power output. PMID:27956870

  7. An optimal tuning strategy for tidal turbines.

    Science.gov (United States)

    Vennell, Ross

    2016-11-01

    Tuning wind and tidal turbines is critical to maximizing their power output. Adopting a wind turbine tuning strategy of maximizing the output at any given time is shown to be an extremely poor strategy for large arrays of tidal turbines in channels. This 'impatient-tuning strategy' results in far lower power output, much higher structural loads and greater environmental impacts due to flow reduction than an existing 'patient-tuning strategy' which maximizes the power output averaged over the tidal cycle. This paper presents a 'smart patient tuning strategy', which can increase array output by up to 35% over the existing strategy. This smart strategy forgoes some power generation early in the half tidal cycle in order to allow stronger flows to develop later in the cycle. It extracts enough power from these stronger flows to produce more power from the cycle as a whole than the existing strategy. Surprisingly, the smart strategy can often extract more power without increasing maximum structural loads on the turbines, while also maintaining stronger flows along the channel. This paper also shows that, counterintuitively, for some tuning strategies imposing a cap on turbine power output to limit loads can increase a turbine's average power output.

  8. Cuckoo Search with Lévy Flights for Weighted Bayesian Energy Functional Optimization in Global-Support Curve Data Fitting

    Directory of Open Access Journals (Sweden)

    Akemi Gálvez

    2014-01-01

    for data fitting by using global-support approximating curves. By global-support curves we mean curves expressed as a linear combination of basis functions whose support is the whole domain of the problem, as opposed to other common approaches in CAD/CAM and computer graphics driven by piecewise functions (such as B-splines and NURBS that provide local control of the shape of the curve. Our method applies a powerful nature-inspired metaheuristic algorithm called cuckoo search, introduced recently to solve optimization problems. A major advantage of this method is its simplicity: cuckoo search requires only two parameters, many fewer than other metaheuristic approaches, so the parameter tuning becomes a very simple task. The paper shows that this new approach can be successfully used to solve our optimization problem. To check the performance of our approach, it has been applied to five illustrative examples of different types, including open and closed 2D and 3D curves that exhibit challenging features, such as cusps and self-intersections. Our results show that the method performs pretty well, being able to solve our minimization problem in an astonishingly straightforward way.

  9. Iterative Feedback Tuning in district heating systems; Iterative Feedback Tuning i vaermeproduktionsanlaeggningar

    Energy Technology Data Exchange (ETDEWEB)

    Raaberg, Martin; Velut, Stephane; Bari, Siavosh Amanat

    2010-10-15

    The project goal is to evaluate and describe how Iterative Feedback Tuning (IFT) can be used to tune controllers in the typical control loops in heat- and power plants. There are only a few practical studies carried out for IFT and they are not really relevant for power and heat processes. It is the practical problems in implementing the IFT and the result of trimming that is the focus of this project. The project will start with theoretical studies of the IFT-method, then realization and simple simulations in scilab. The IFT equations are then implemented in Freelance 2000, an ABB control system, for practical tests on a SISO- and a MIMO-process. By performing reproducible experiments on the process and analyze the results IFT can adjust the controller parameters to minimize a cost function that represents the control goal. The project selected for SISO experiments a pressure controller in an oil transportation system. By controlling the valve position of a control valve for the reversal to the supply tank, the pressure in the oil transport system is regulated. A disturbance in oil pressure can be achieved by changing the position of a valve that lets oil through to the day tank. The selected MIMO-process is a pre-heater in a degassing process. In this process, a valve on the secondary side is utilized to control the flow in the secondary system. A valve on the primary side is utilized to control the district heating water flow through the heat exchanger to control the temperature on the secondary side. An increased secondary flow increases the heat demand and thus requiring an increase in primary flow to maintain the secondary side outlet temperature. This is the cross-coupling responsible for why it is an advantage to consider the process as multi-variable. Using the IFT method, the two original PID-controllers and a feed-forward controller is tuned simultaneously. IFT-method was difficult to implement but worked well in both simulations and in real processes

  10. Small Commercial Building Re-tuning: A Primer

    Energy Technology Data Exchange (ETDEWEB)

    Cort, Katherine A.; Hostick, Donna J.; Underhill, Ronald M.; Fernandez, Nicholas; Katipamula, Srinivas

    2013-09-30

    To help building owners and managers address issues related to energy-efficient operation of small buildings, DOE has developed a Small Building Re-tuning training curriculum. This "primer" provides additional background information to understand some of the concepts presented in the Small Building Re-tuning training. The intent is that those who are less familiar with the buidling energy concepts will review this material before taking the building re-tuning training class.

  11. Oracle SQL Tuning pocket Reference

    CERN Document Server

    Gurry, Mark

    2002-01-01

    One of the most important challenges faced by Oracle database administrators and Oracle developers is the need to tune SQL statements so that they execute efficiently. Poorly tuned SQL statements are one of the leading causes of substandard database performance and poor response time. SQL statements that perform poorly result in frustration for users, and can even prevent a company from serving its customers in a timely manner

  12. Micromechanical Model for Deformation in Solids with Universal Predictions for Stress-Strain Curves and Slip Avalanches

    International Nuclear Information System (INIS)

    Dahmen, Karin A.; Ben-Zion, Yehuda; Uhl, Jonathan T.

    2009-01-01

    A basic micromechanical model for deformation of solids with only one tuning parameter (weakening ε) is introduced. The model can reproduce observed stress-strain curves, acoustic emissions and related power spectra, event statistics, and geometrical properties of slip, with a continuous phase transition from brittle to ductile behavior. Exact universal predictions are extracted using mean field theory and renormalization group tools. The results agree with recent experimental observations and simulations of related models for dislocation dynamics, material damage, and earthquake statistics.

  13. Stress-tuned conductor-polymer composite for use in sensors

    Science.gov (United States)

    Martin, James E; Read, Douglas H

    2013-10-22

    A method for making a composite polymeric material with electrical conductivity determined by stress-tuning of the conductor-polymer composite, and sensors made with the stress-tuned conductor-polymer composite made by this method. Stress tuning is achieved by mixing a miscible liquid into the polymer precursor solution or by absorbing into the precursor solution a soluble compound from vapor in contact with the polymer precursor solution. The conductor may or may not be ordered by application of a magnetic field. The composite is formed by polymerization with the stress-tuning agent in the polymer matrix. The stress-tuning agent is removed following polymerization to produce a conductor-polymer composite with a stress field that depends on the amount of stress-tuning agent employed.

  14. New ATLAS event generator tunes to 2010 data

    CERN Document Server

    The ATLAS collaboration

    2011-01-01

    This note describes the Monte Carlo event generator tunings for the Pythia 6 and Herwig/Jimmy generators in the ATLAS MC11 simulation production. New tunes have been produced for these generators, making maximal use of available published data from ATLAS and from the Tevatron and LEP experiments. Particular emphasis has been placed on improvement of the description of e+ e− event shape and jet rate data, and on description of hadron collider event shape observables in Pythia, as well as the established procedure of tuning the multiple parton interactions of both models to describe underlying event and minimum bias data. The tuning of Pythia is provided at this time for the MRST LO∗∗ PDF, while the purely MPI tune of Herwig/Jimmy is performed for ten different PDFs.

  15. Cosmological constant problem and renormalized vacuum energy density in curved background

    Energy Technology Data Exchange (ETDEWEB)

    Kohri, Kazunori [Theory Center, IPNS, KEK, Tsukuba 305-0801, Ibaraki (Japan); Matsui, Hiroki, E-mail: kohri@post.kek.jp, E-mail: matshiro@post.kek.jp [The Graduate University of Advanced Studies (Sokendai), Tsukuba 305-0801, Ibaraki (Japan)

    2017-06-01

    The current vacuum energy density observed as dark energy ρ{sub dark}≅ 2.5×10{sup −47} GeV{sup 4} is unacceptably small compared with any other scales. Therefore, we encounter serious fine-tuning problem and theoretical difficulty to derive the dark energy. However, the theoretically attractive scenario has been proposed and discussed in literature: in terms of the renormalization-group (RG) running of the cosmological constant, the vacuum energy density can be expressed as ρ{sub vacuum}≅ m {sup 2} H {sup 2} where m is the mass of the scalar field and rather dynamical in curved spacetime. However, there has been no rigorous proof to derive this expression and there are some criticisms about the physical interpretation of the RG running cosmological constant. In the present paper, we revisit the RG running effects of the cosmological constant and investigate the renormalized vacuum energy density in curved spacetime. We demonstrate that the vacuum energy density described by ρ{sub vacuum}≅ m {sup 2} H {sup 2} appears as quantum effects of the curved background rather than the running effects of cosmological constant. Comparing to cosmological observational data, we obtain an upper bound on the mass of the scalar fields to be smaller than the Planck mass, m ∼< M {sub Pl}.

  16. Parametric thermo-hydraulic analysis of the TF system of JT-60SA during fast discharge

    International Nuclear Information System (INIS)

    Polli, Gian Mario; Lacroix, Benoit; Zani, Louis; Besi Vetrella, Ugo; Cucchiaro, Antonio

    2013-01-01

    Highlights: • We modeled the central clock-wise pancake of JT-60SA TF magnet at the EOB. • We simulated a quench followed by a fast discharge. • We evaluated the temperature and pressure rises in the nominal configuration. • We evaluated the effect of several parameter changes on the thermal-hydraulic response of the system. -- Abstract: The evolution of the conductor temperature and of the helium pressure of the central pancake of the TF superconducting magnet of the JT-60SA tokamak in a quench scenario are here discussed. The quench is triggered by a heat disturbance applied at the end of burning and followed by a fast safety discharge. A parametric study aimed at assessing the robustness of the calculation is also addressed with special regard to the voltage threshold, used to define the occurrence of the quench, and to the time delay, that cover all the possible delays in the fast discharge after quench detection. Finally, due to sensitivity analyses the influences of different parameters were assessed: the material properties of the strands (RRR, copper fraction), the magnitude and the spatial length of the triggering disturbance and the magnetic field distribution. The numerical evaluations were performed in the framework of the Broader Approach Agreement in collaboration with CEA, ENEA and the JT-60SA European Home Team using the 1D code Gandalf [1

  17. Tuning and History: A Personal Overview

    Science.gov (United States)

    Isaacs, Ann Katherine

    2017-01-01

    The text places Tuning History in the context of the rapidly developing international collaboration among historians which began in Europe in 1989, with the ECTS Pilot project, and continued, from 2000 on, with the European History Networks (for research and for curriculum development) working in parallel and in collaboration with Tuning, in…

  18. Linear beam-beam tune shift calculations for the Tevatron Collider

    International Nuclear Information System (INIS)

    Johnson, D.

    1989-01-01

    A realistic estimate of the linear beam-beam tune shift is necessary for the selection of an optimum working point in the tune diagram. Estimates of the beam-beam tune shift using the ''Round Beam Approximation'' (RBA) have over estimated the tune shift for the Tevatron. For a hadron machine with unequal lattice functions and beam sizes, an explicit calculation using the beam size at the crossings is required. Calculations for various Tevatron lattices used in Collider operation are presented. Comparisons between the RBA and the explicit calculation, for elliptical beams, are presented. This paper discusses the calculation of the linear tune shift using the program SYNCH. Selection of a working point is discussed. The magnitude of the tune shift is influenced by the choice of crossing points in the lattice as determined by the pbar ''cogging effects''. Also discussed is current cogging procedures and presents results of calculations for tune shifts at various crossing points in the lattice. Finally, a comparison of early pbar tune measurements with the present linear tune shift calculations is presented. 17 refs., 13 figs., 3 tabs

  19. Tuning of Clic accelerating structure prototypes at CERN

    CERN Document Server

    Shi, J; Olyunin, A; Wuensch, W

    2010-01-01

    An RF measurement system has been set up at CERN for use in the X-band accelerating structure development program of the CLIC study. Using the system, S-parameters are measured and the field distribution is obtained automatically using a bead-pull technique. The corrections for tuning the structure are calculated from an initial measurement and cell-by-cell tuning is applied to obtain the correct phase advance and minimum reflection at the operation frequency. The detailed tuning procedure is presented and explained along with an example of measurement and tuning of CLIC accelerating structure prototypes.

  20. Separation of toluene from n-heptane by liquid–liquid extraction using binary mixtures of [bpy][BF4] and [4bmpy][Tf2N] ionic liquids as solvent

    International Nuclear Information System (INIS)

    García, Silvia; Larriba, Marcos; García, Julián; Torrecilla, José S.; Rodríguez, Francisco

    2012-01-01

    Highlights: ► Binary mixtures of ionic liquids as extraction solvents of aromatics. ► [4bmpy][Tf 2 N] shows higher capacity but lower selectivity than sulfolane. ► [bpy][BF 4 ] shows lower capacity but higher selectivity than sulfolane. ► Mixed {[4bmpy][Tf 2 N] + [bpy][BF 4 ]} improves both extractive properties. - Abstract: The use of binary mixture of ionic liquids N-butylpyridinium tetrafluoroborate ([bpy][BF 4 ]), and 1-butyl-4-methylpyridinium bis(trifluoromethylsulfonyl)imide ([4bmpy][Tf 2 N]) in the liquid–liquid extraction of toluene from n-heptane has been investigated at 313.2 K and atmospheric pressure. The experimental capacity of extraction and selectivity for this binary mixture has proved to be intermediate to those corresponding to the pure ionic liquids, and they can be predicted using a logarithmic–linear model of solubility. Furthermore, the results showed that the use of binary mixture of {[bpy][BF 4 ] + [4bmpy][Tf 2 N]} at a mole solvent composition around 0.7 for [bpy][BF 4 ] improves both the capacity of extraction of toluene and the selectivity with respect to those of sulfolane, the organic solvent taken as a benchmark. Thus, this mixed ionic liquid could be likely to be used in the extraction of aromatic from aliphatic in replacement to sulfolane.

  1. Spin tune dependence on closed orbit in RHIC

    International Nuclear Information System (INIS)

    Ptitsyn, V.; Bai, M.; Roser, T.

    2010-01-01

    Polarized proton beams are accelerated in RHIC to 250 GeV energy with the help of Siberian Snakes. The pair of Siberian Snakes in each RHIC ring holds the design spin tune at 1/2 to avoid polarization loss during acceleration. However, in the presence of closed orbit errors, the actual spin tune can be shifted away from the exact 1/2 value. It leads to a corresponding shift of locations of higher-order ('snake') resonances and limits the available betatron tune space. The largest closed orbit effect on the spin tune comes from the horizontal orbit angle between the two snakes. During RHIC Run in 2009 dedicated measurements with polarized proton beams were taken to verify the dependence of the spin tune on the local orbits at the Snakes. The experimental results are presented along with the comparison with analytical predictions.

  2. Integrated unaligned resonant modulator tuning

    Energy Technology Data Exchange (ETDEWEB)

    Zortman, William A.; Lentine, Anthony L.

    2017-10-03

    Methods and systems for tuning a resonant modulator are disclosed. One method includes receiving a carrier signal modulated by the resonant modulator with a stream of data having an approximately equal number of high and low bits, determining an average power of the modulated carrier signal, comparing the average power to a predetermined threshold, and operating a tuning device coupled to the resonant modulator based on the comparison of the average power and the predetermined threshold. One system includes an input structure, a plurality of processing elements, and a digital control element. The input structure is configured to receive, from the resonant modulator, a modulated carrier signal. The plurality of processing elements are configured to determine an average power of the modulated carrier signal. The digital control element is configured to operate a tuning device coupled to the resonant modulator based on the average power of the modulated carrier signal.

  3. Efficient Thermal Tuning Employing Metallic Microheater With Slow Light Effect

    DEFF Research Database (Denmark)

    Yan, Siqi; Chen, Hao; Gao, Shengqian

    2018-01-01

    Thermal tuning acts as one of the most fundamental roles in integrated silicon photonics since it can provide flexibility and reconfigurability. Low tuning power and fast tuning speed are long-term pursuing goals in terms of the performance of the thermal tuning. Here we propose and experimentall...

  4. Online control loop tuning in Pickering Nuclear Generating Stations

    International Nuclear Information System (INIS)

    Yu, K.X.; Harrington, S.

    2008-01-01

    Most analog controllers in the Pickering B Nuclear Generating Stations adopted PID control scheme. In replacing the analog controllers with digital controllers, the PID control strategies, including the original tuning parameters were retained. The replacement strategy resulted in minimum effort on control loop tuning. In a few cases, however, it was found during commissioning that control loop tuning was required as a result of poor control loop performance, typically due to slow response and controlled process oscillation. Several factors are accounted for the necessities of control loop re-tuning. Our experience in commissioning the digital controllers showed that online control tuning posted some challenges in nuclear power plant. (author)

  5. Heavy superpartners with less tuning from hidden sector renormalisation

    International Nuclear Information System (INIS)

    Hardy, Edward

    2014-01-01

    In supersymmetric extensions of the Standard Model, superpartner masses consistent with collider bounds typically introduce significant tuning of the electroweak scale. We show that hidden sector renormalisation can greatly reduce such a tuning if the supersymmetry breaking, or mediating, sector runs through a region of strong coupling not far from the weak scale. In the simplest models, only the tuning due to the gaugino masses is improved, and a weak scale gluino mass in the region of 5 TeV may be obtained with an associated tuning of only one part in ten. In models with more complex couplings between the visible and hidden sectors, the tuning with respect to sfermions can also be reduced. We give an example of a model, with low scale gauge mediation and superpartner masses allowed by current LHC bounds, that has an overall tuning of one part in twenty

  6. Mammalian odorant receptor tuning breadth persists across distinct odorant panels.

    Directory of Open Access Journals (Sweden)

    Devin Kepchia

    Full Text Available The molecular receptive range (MRR of a mammalian odorant receptor (OR is the set of odorant structures that activate the OR, while the distribution of these odorant structures across odor space is the tuning breadth of the OR. Variation in tuning breadth is thought to be an important property of ORs, with the MRRs of these receptors varying from narrowly to broadly tuned. However, defining the tuning breadth of an OR is a technical challenge. For practical reasons, a screening panel that broadly covers odor space must be limited to sparse coverage of the many potential structures in that space. When screened with such a panel, ORs with different odorant specificities, but equal tuning breadths, might appear to have different tuning breadths due to chance. We hypothesized that ORs would maintain their tuning breadths across distinct odorant panels. We constructed a new screening panel that was broadly distributed across an estimated odor space and contained compounds distinct from previous panels. We used this new screening panel to test several murine ORs that were previously characterized as having different tuning breadths. ORs were expressed in Xenopus laevis oocytes and assayed by two-electrode voltage clamp electrophysiology. MOR256-17, an OR previously characterized as broadly tuned, responded to nine novel compounds from our new screening panel that were structurally diverse and broadly dispersed across an estimated odor space. MOR256-22, an OR previously characterized as narrowly tuned, responded to a single novel compound that was structurally similar to a previously known ligand for this receptor. MOR174-9, a well-characterized receptor with a narrowly tuned MRR, did not respond to any novel compounds in our new panel. These results support the idea that variation in tuning breadth among these three ORs is not an artifact of the screening protocol, but is an intrinsic property of the receptors.

  7. Manufacturability of Wood Plastic Composite Sheets on the Basis of the Post-Processing Cooling Curve

    Directory of Open Access Journals (Sweden)

    Sami Matthews

    2015-10-01

    Full Text Available Extruded wood-plastic composites (WPCs are increasingly regarded as promising materials for future manufacturing industries. It is necessary to select and tune the post-processing methods to be able to utilize these materials fully. In this development, temperature-related material properties and the cooling rate are important indicators. This paper presents the results of natural cooling in a factory environment fit into a cooling curve function with temperature zones for forming, cutting, and packaging overlaid using a WPC material. This information is then used in the evaluation of manufacturability and productivity in terms of cost effectiveness and technical quality by comparing the curve to actual production time data derived from a prototype post-process forming line. Based on this information, speed limits for extrusion are presented. This paper also briefly analyzes techniques for controlling material cooling to counter the heat loss before post-processing.

  8. Trauma-Focused Early Intensive Cognitive Behavioral Intervention (TF-EICBI) in children and adolescent survivors of suicide bombing attacks (SBAs). A preliminary study.

    Science.gov (United States)

    Leor, Agnes; Dolberg, Orna T; Eshel, Shira Pagorek; Yagil, Yaron; Schreiber, Shaul

    2013-01-01

    To describe and evaluate the impact of an early intervention (Trauma-Focused Early Intensive Cognitive Behavioral Intervention, TF-EICBI) in children and adolescents who were victims of suicide bombing attacks (SBAs) in Israel. Description of an intervention and preliminary experience in its use. An acute trauma center of a Child and Adolescent Psychiatric Unit in a Department of Psychiatry of a university-affiliated medical center. Ten children and adolescents who were victims of SBAs and underwent early interventions (EIG) were compared to 11 adolescent victims who received no intervention (NEIG). The EIG included all the children and adolescent survivors of various SBAs that had occurred during 1 year who presented to our hospital after the TF-EICBI was implemented (June 2001). The NEIG comprised all adolescents girls children and adolescents after SBAs.

  9. Application of calorimetry to the assessment of the performance of ITER Nb3Sn TF conductor samples in SULTAN tests

    International Nuclear Information System (INIS)

    Richard, L Savoldi; Zanino, R

    2008-01-01

    In the frame of the International Thermonuclear Experimental Reactor (ITER), several short full-size Nb 3 Sn samples of candidate toroidal field (TF) conductors were tested in 2007 at the SULTAN facility, PSI Villigen, Switzerland, in conditions relevant to the ITER TF (background magnetic field of 10.78 T and transport current of 68 kA). The performance of a SULTAN sample is determined by the current sharing temperature T CS . This can be obtained in principle from voltage measurements along the conductor sample, but the procedure is not free of issues and ambiguities. Here a complementary approach, based on the calorimetric assessment of the Joule heating due to current sharing, is critically discussed. Suitable algorithms are defined and the respective error bars are estimated, also based on numerical thermal-hydraulic modeling. The calorimetric approach is then applied to assess the performance of the samples tested in 2007 and compared with the results of the standard (electrical) approach

  10. Sizing optimization of skeletal structures using teaching-learning based optimization

    Directory of Open Access Journals (Sweden)

    Vedat Toğan

    2017-03-01

    Full Text Available Teaching Learning Based Optimization (TLBO is one of the non-traditional techniques to simulate natural phenomena into a numerical algorithm. TLBO mimics teaching learning process occurring between a teacher and students in a classroom. A parameter named as teaching factor, TF, seems to be the only tuning parameter in TLBO. Although the value of the teaching factor, TF, is determined by an equation, the value of 1 or 2 has been used by the researchers for TF. This study intends to explore the effect of the variation of teaching factor TF on the performances of TLBO. This effect is demonstrated in solving structural optimization problems including truss and frame structures under the stress and displacement constraints. The results indicate that the variation of TF in the TLBO process does not change the results obtained at the end of the optimization procedure when the computational cost of TLBO is ignored.

  11. Emergence of curved light-cones in a class of inhomogeneous Luttinger liquids

    Directory of Open Access Journals (Sweden)

    Jérôme Dubail, Jean-Marie Stéphan, Pasquale Calabrese

    2017-09-01

    Full Text Available The light-cone spreading of entanglement and correlation is a fundamental and ubiquitous feature of homogeneous extended quantum systems. Here we point out that a class of inhomogenous Luttinger liquids (those with a uniform Luttinger parameter $K$ at low energy display the universal phenomenon of curved light cones: gapless excitations propagate along the geodesics of the metric $ds^2=dx^2+v(x^2 d\\tau^2$, with $v(x$ being the calculable spatial dependent velocity induced by the inhomogeneity. We confirm our findings with explicit analytic and numerical calculations both in- and out-of-equilibrium for a Tonks-Girardeau gas in a harmonic potential and in lattice systems with artificially tuned hamiltonian density.

  12. Astronomical tuning and carbon isotope stratigraphy of the Maastrichtian in Sopelana and Zumaia (Basque country, N-Spain)

    Science.gov (United States)

    Batenburg, S. J.; Gale, A. S.; Hilgen, F. J.; Hüsing, S. K.; Laskar, J.; Orue-Etxebarria, X.; Sprovieri, M.; Voigt, S.

    2012-04-01

    Astronomical tuning has led to significant refinement of the Geological Time Scale for the Cenozoic, however the Late Cretaceous time scale still has potential errors of ~0.5 Myr. The Basque sections of Sopelana and Zumaia (N-Spain) provide a high-resolution sedimentary archive encompassing the Maastrichtian up to the Cretaceous/Paleogene boundary. Rhythmic limestone-marl alternations, deposited in a hemipelagic setting, reflect the influence of the periodicities of eccentricity modulated precession. Starting from a K/Pg boundary age of 66.0 Ma, consecutive 405-kyr minima are tuned to the new astronomical solution La2011. This orbital tuning, together with the expression of individual precessional cycles, allows for unprecedented refinement of the Geologic Time Scale for the Maastrichtian with errors analysis of magnetic susceptibility and colour reflectance data. A cyclostratigraphic framework and orbital tuning of the Zumaia section has recently been obtained. This is extended further back in time by correlation to the Sopelana section by recognition of orbital patterns and marker beds. The total amount of time represented by the two sections is 5 Myr. The lower boundary falls within chron C32N1n, almost reaching the Campanian/Maastrichtian boundary. Magnetostratigraphic and biostratigraphic data allow for application of the cyclostratigraphic framework worldwide, and comparison to previously published Maastrichtian time scales. Additionally, we present an orbitally tuned bulk carbon isotope curve. The high resolution and large amplitude of shifts in δ13C on the 405-kyr and 1.2-Myr scales enables correlation to deep marine oceanic sites, several sections from the Boreal chalk sea and Italy and, importantly, the Campanian/Maastrichtian boundary GSSP at Tercis, France. This will provide a globally applicable cyclostratigraphic framework for the entire Maastrichtian. We will discuss the implications for the orbital pacing theory of the late Cretaceous climate

  13. 70 MeV injector auto tuning system handbook

    International Nuclear Information System (INIS)

    Ellis, J.E.; Munn, R.W.; Sandels, E.G.

    1976-06-01

    The handbook is in three sections: (1) description and location; (2) operating instructions; and (3) design notes on the tank and debuncher auto tuning systems for the 70 MeV injector. The purpose of the auto tuning system is to maintain the 'tune' of the four tanks and debuncher to within a few Hz, stabilizing against changes of temperature and other physical factors affecting the resonant frequency of the tanks. (U.K.)

  14. Quench propagation and quench detection in the TF system of JT-60SA

    International Nuclear Information System (INIS)

    Lacroix, Benoit; Duchateau, Jean-Luc; Meuris, Chantal; Ciazynski, Daniel; Nicollet, Sylvie; Zani, Louis; Polli, Gian-Mario

    2013-01-01

    Highlights: • The JT-60SA primary quench detection system will be based on voltage measurements. • The early quench propagation was studied in the JT-60SA TF conductor. • The impact of the conductor jacket on the hot spot criterion was quantified. • The detection parameters were investigated for different quench initiations. -- Abstract: In the framework of the JT-60SA project, France and Italy will provide to JAEA 18 Toroidal Field (TF) coils including NbTi cable-in-conduit conductors. During the tokamak operation, these coils could experience a quench, an incidental event corresponding to the irreversible transition from superconducting state to normal resistive state. Starting from a localized disturbance, the normal zone propagates along the conductor and dissipates a large energy due to Joule heating, which can cause irreversible damages. The detection has to be fast enough (a few seconds) to trigger the current discharge, so as to dump the stored magnetic energy into an external resistor. The JT-60SA primary quench detection system will be based on voltage measurements, which are the most rapid technology. The features of the detection system must be adjusted so as to detect the most probable quenches, while avoiding inopportune fast safety discharges. This requires a reliable simulation of the early quench propagation, performed in this study with the Gandalf code. The conductor temperature reached during the current discharge must be kept under a maximal value, according to the hot spot criterion. In the present study, a hot spot criterion temperature of 150 K was taken into account and the role of each conductor component (strands, helium and conduit) was analyzed. The detection parameters were then investigated for different hypotheses regarding the quench initiation

  15. ATLAS tunes of PYTHIA 6 and Pythia 8 for MC11

    CERN Document Server

    The ATLAS collaboration

    2011-01-01

    We present the latest developments of the ATLAS MC generator tuning project for the Pythia family of event generators, including the C++ Pythia 8 code for the first time. The PYTHIA 6 tunes presented here, titled AMBT2B and AUET2B and constructed for a variety of PDFs, constitute alternatives to the AMBT2/AUET2 tunes previously presented as a candidate for MC11 event simulation. They systematically differ from the AMBT2/AUET2 PYTHIA 6 tunes in the treatment of alpha_S, to address concerns with those tunes. Systematic tune variations are also presented. The Pythia 8 tunes have been constructed for two different PDFs, and are aimed at an optimal description of minimum bias, for use in pile-up simulation. PDF-sensitive effects are observed and discussed in the MPI tunings of both generators.

  16. Self-tuning control studies of the plasma vertical position problem

    International Nuclear Information System (INIS)

    Zheng, Guang Lin; Wellstead, P.E.; Browne, M.L.

    1993-01-01

    The plasma vertical position system in a tokamak device can be open-loop unstable with time-varying dynamics, such that the instability increases with system dynamical changes. Time-varying unstable dynamics makes the plasma vertical position a particularly difficult one to control with traditional fixed-coefficient controllers. A self-tuning technique offers a new solution of the plasma vertical position control problem by an adaptive control approach. Specifically, the self-tuning controller automatically tunes the controller parameters without an a priori knowledge of the system dynamics and continuously tracks dynamical changes within the system, thereby providing the system with auto-tuning and adaptive tuning capabilities. An overview of the self-tuning methods is given, and their applicability to a simulation of the Joint European Torus (JET) vertical plasma positions system is illustrated. Specifically, the applicability of pole-assignment and generalized predictive control self-tuning methods to the vertical plasma position system is demonstrated. 26 refs., 16 figs., 1 tab

  17. A frequency domain approach for MPC tuning

    NARCIS (Netherlands)

    Özkan, L.; Meijs, J.B.; Backx, A.C.P.M.; Karimi, I.A.; Srinivasan, R.

    2012-01-01

    This paper presents a frequency domain based approach to tune the penalty weights in the model predictive control (MPC) formulation. The two-step tuning method involves the design of a favourite controller taking into account the model-plant mismatch followed by the controller matching. We implement

  18. Natural tuning: towards a proof of concept

    Science.gov (United States)

    Dubovsky, Sergei; Gorbenko, Victor; Mirbabayi, Mehrdad

    2013-09-01

    The cosmological constant problem and the absence of new natural physics at the electroweak scale, if confirmed by the LHC, may either indicate that the nature is fine-tuned or that a refined notion of naturalness is required. We construct a family of toy UV complete quantum theories providing a proof of concept for the second possibility. Low energy physics is described by a tuned effective field theory, which exhibits relevant interactions not protected by any symmetries and separated by an arbitrary large mass gap from the new "gravitational" physics, represented by a set of irrelevant operators. Nevertheless, the only available language to describe dynamics at all energy scales does not require any fine-tuning. The interesting novel feature of this construction is that UV physics is not described by a fixed point, but rather exhibits asymptotic fragility. Observation of additional unprotected scalars at the LHC would be a smoking gun for this scenario. Natural tuning also favors TeV scale unification.

  19. Accurate guitar tuning by cochlear implant musicians.

    Directory of Open Access Journals (Sweden)

    Thomas Lu

    Full Text Available Modern cochlear implant (CI users understand speech but find difficulty in music appreciation due to poor pitch perception. Still, some deaf musicians continue to perform with their CI. Here we show unexpected results that CI musicians can reliably tune a guitar by CI alone and, under controlled conditions, match simultaneously presented tones to <0.5 Hz. One subject had normal contralateral hearing and produced more accurate tuning with CI than his normal ear. To understand these counterintuitive findings, we presented tones sequentially and found that tuning error was larger at ∼ 30 Hz for both subjects. A third subject, a non-musician CI user with normal contralateral hearing, showed similar trends in performance between CI and normal hearing ears but with less precision. This difference, along with electric analysis, showed that accurate tuning was achieved by listening to beats rather than discriminating pitch, effectively turning a spectral task into a temporal discrimination task.

  20. BOREAS TF-3 Automated Chamber CO2 Flux Data from the NSA-OBS

    Science.gov (United States)

    Goulden, Michael L.; Crill, Patrick M.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem Atmosphere Study Tower Flux (BOREAS TF-3) and Trace Gas Biogeochemistry (TGB-1) teams collected automated CO2 chamber flux data in their efforts to fully describe the CO2 flux at the Northern Study Area-Old Black Spruce (NSA-OBS) site. This data set contains fluxes of CO2 at the NSA-OBS site measured using automated chambers. In addition to reporting the CO2 flux, it reports chamber air temperature, moss temperature, and light levels during each measurement. The data set covers the period from 23-Sep-1995 through 26-Oct-1995 and from 28-May-1996 through 21-Oct-1996. The data are stored in tabular ASCII files.

  1. Further ATLAS tunes of PYTHIA6 and Pythia 8

    CERN Document Server

    The ATLAS collaboration

    2011-01-01

    We present the latest developments of the ATLAS MC generator tuning project for the Pythia family of event generators, including the C++ Pythia 8 code. The PYTHIA 6 tunes presented here complete the ``AUET2B'' set by addition of parton shower and multi-parton interaction model tunings with three next-to-leading order (NLO) PDFs in addition to the leading-order and MC-adapted PDFs previously presented. This note also presents systematic variation ``eigentunes'' for the parton shower configurations in the AMBT2B/AUET2B tune series. The Pythia 8 MPI tunes in this note have been constructed for six different PDFs, making use of a new $x$-dependent hadronic matter distribution model. MPI eigentunes are constructed for the PDFs intended for use in ATLAS bulk MC production.

  2. Predictive Performance Tuning of OpenACC Accelerated Applications

    KAUST Repository

    Siddiqui, Shahzeb

    2014-05-04

    Graphics Processing Units (GPUs) are gradually becoming mainstream in supercomputing as their capabilities to significantly accelerate a large spectrum of scientific applications have been clearly identified and proven. Moreover, with the introduction of high level programming models such as OpenACC [1] and OpenMP 4.0 [2], these devices are becoming more accessible and practical to use by a larger scientific community. However, performance optimization of OpenACC accelerated applications usually requires an in-depth knowledge of the hardware and software specifications. We suggest a prediction-based performance tuning mechanism [3] to quickly tune OpenACC parameters for a given application to dynamically adapt to the execution environment on a given system. This approach is applied to a finite difference kernel to tune the OpenACC gang and vector clauses for mapping the compute kernels into the underlying accelerator architecture. Our experiments show a significant performance improvement against the default compiler parameters and a faster tuning by an order of magnitude compared to the brute force search tuning.

  3. Improvements, enhancements, and optimizations of COBRA-TF

    International Nuclear Information System (INIS)

    Salko, R. K.; Avramova, M. N.; Hooper, R.; Palmtag, S.; Popov, E.; Turner, J.

    2013-01-01

    The Reactor Dynamics and Fuel Management Group (RDFMG) at The Pennsylvania State University (PSU) has become active in the Consortium for Advanced Simulation of Light Water Reactors (CASL) program by delivering, supporting, and further developing CTF, the PSU version of the Coolant Boiling in Rod Arrays - Two Fluids (COBRA-TF) Thermal/Hydraulic (T/H), sub-channel program. New development work on CTF was primarily geared towards decreasing the execution time of the code so that it may eventually be used for performing pin-by-pin, full-core simulations. Great gains have been made through targeting sections of source code for optimization. For example, wall clock time has been reduced for a one-assembly, three-dimensional model, containing ∼9,400 mesh cells, from 9.2 min to 1 min. A further improvement has been reduction in code memory usage, which was previously prohibitive for large models. In conjunction with the run time speedups, this has enabled the simulation of a refined quarter-core model (∼460,000 mesh cells), which saw a reduction in memory usage from over 130 GB to less than 3 GB. In addition to the optimization work, RDFMG has also created a preprocessor utility for the fast and less error-prone generation of CTF input decks. Furthermore, basic post-processing capabilities have been implemented by creating a CTF subroutine for producing Visualization Tool-Kit (VTK) files that output mesh data and associated simulation results. These VTK files can be opened with visualization software. (authors)

  4. Reducing the fine-tuning of gauge-mediated SUSY breaking

    Energy Technology Data Exchange (ETDEWEB)

    Casas, J.A.; Moreno, Jesus M. [Universidad Autonoma de Madrid, Instituto de Fisica Teorica, IFT-UAM/CSIC, Madrid (Spain); Robles, Sandra [Universidad Autonoma de Madrid, Instituto de Fisica Teorica, IFT-UAM/CSIC, Madrid (Spain); Universidad Autonoma de Madrid, Departamento de Fisica Teorica, Madrid (Spain); Rolbiecki, Krzysztof [Universidad Autonoma de Madrid, Instituto de Fisica Teorica, IFT-UAM/CSIC, Madrid (Spain); University of Warsaw, Faculty of Physics, Warsaw (Poland)

    2016-08-15

    Despite their appealing features, models with gauge-mediated supersymmetry breaking (GMSB) typically present a high degree of fine-tuning, due to the initial absence of the top trilinear scalar couplings, A{sub t} = 0. In this paper, we carefully evaluate such a tuning, showing that is worse than per mil in the minimal model. Then, we examine some existing proposals to generate A{sub t} ≠ 0 term in this context. We find that, although the stops can be made lighter, usually the tuning does not improve (it may be even worse), with some exceptions, which involve the generation of A{sub t} at one loop or tree level. We examine both possibilities and propose a conceptually simplified version of the latter; which is arguably the optimum GMSB setup (with minimal matter content), concerning the fine-tuning issue. The resulting fine-tuning is better than one per mil, still severe but similar to other minimal supersymmetric standard model constructions. We also explore the so-called ''little A{sub t}{sup 2}/m{sup 2} problem'', i.e. the fact that a large A{sub t}-term is normally accompanied by a similar or larger sfermion mass, which typically implies an increase in the fine-tuning. Finally, we find the version of GMSB for which this ratio is optimized, which, nevertheless, does not minimize the fine-tuning. (orig.)

  5. Distributed Tuning of Boundary Resources

    DEFF Research Database (Denmark)

    Eaton, Ben; Elaluf-Calderwood, Silvia; Sørensen, Carsten

    2015-01-01

    in the context of a paradoxical tension between the logic of generative and democratic innovations and the logic of infrastructural control. Boundary resources play a critical role in managing the tension as a firm that owns the infrastructure can secure its control over the service system while independent...... firms can participate in the service system. In this study, we explore the evolution of boundary resources. Drawing on Pickering’s (1993) and Barrett et al.’s (2012) conceptualizations of tuning, the paper seeks to forward our understanding of how heterogeneous actors engage in the tuning of boundary...

  6. Towards automatic parameter tuning of stream processing systems

    KAUST Repository

    Bilal, Muhammad; Canini, Marco

    2017-01-01

    for automating parameter tuning for stream-processing systems. Our framework supports standard black-box optimization algorithms as well as a novel gray-box optimization algorithm. We demonstrate the multiple benefits of automated parameter tuning in optimizing

  7. Tuning and backreaction in F-term axion monodromy inflation

    Directory of Open Access Journals (Sweden)

    Arthur Hebecker

    2015-05-01

    Full Text Available We continue the development of axion monodromy inflation, focusing in particular on the backreaction of complex structure moduli. In our setting, the shift symmetry comes from a partial large complex structure limit of the underlying type IIB orientifold or F-theory fourfold. The coefficient of the inflaton term in the superpotential has to be tuned small to avoid conflict with Kähler moduli stabilisation. To allow such a tuning, this coefficient necessarily depends on further complex structure moduli. At large values of the inflaton field, these moduli are then in danger of backreacting too strongly. To avoid this, further tunings are necessary. In weakly coupled type IIB theory at the orientifold point, implementing these tunings appears to be difficult if not impossible. However, fourfolds or models with mobile D7-branes provide enough structural freedom. We calculate the resulting inflaton potential and study the feasibility of the overall tuning given the limited freedom of the flux landscape. Our preliminary investigations suggest that, even imposing all tuning conditions, the remaining choice of flux vacua can still be large enough for such models to provide a promising path to large-field inflation in string theory.

  8. Self tuning fuzzy PID type load and frequency controller

    International Nuclear Information System (INIS)

    Yesil, E.; Guezelkaya, M.; Eksin, I.

    2004-01-01

    In this paper, a self tuning fuzzy PID type controller is proposed for solving the load frequency control (LFC) problem. The fuzzy PID type controller is constructed as a set of control rules, and the control signal is directly deduced from the knowledge base and the fuzzy inference. Moreover, there exists a self tuning mechanism that adjusts the input scaling factor corresponding to the derivative coefficient and the output scaling factor corresponding to the integral coefficient of the PID type fuzzy logic controller in an on-line manner. The self tuning mechanism depends on the peak observer idea, and this idea is modified and adapted to the LFC problem. A two area interconnected system is assumed for demonstrations. The proposed self tuning fuzzy PID type controller has been compared with the fuzzy PID type controller without a self tuning mechanism and the conventional integral controller through some performance indices

  9. Philips Gemini TF64 PET/CT Acceptance Testing

    International Nuclear Information System (INIS)

    González Gonzalez, Joaquín J.; Calderón Marin, Carlos F.; Varela Corona, Consuelo; Machado Tejeda, Adalberto; González Correa, Héctor J.

    2016-01-01

    The Philips Gemini TF64 is the first PET/CT scanner installed in Cuba at the Institute of Oncology and Radiobiology in 2014. It is a third generation fully tridimensional whole body PET scanner with time-of-flight (TOF) technology combined with a 64-slice Brilliance CT scanner. The CT detector module contains 672x64 solid state detector, incorporating GOS scintillators, optical diodes and electronic signal channels arranged in 64 side by side arcs, with 672 detectors in each arc. There are sixteen 0.75 mm individual detector elements around the center and four 1.5 mm elements at each end, resulting in a 24 mm total detection length. The PET detector consists of 28 pixelar modules of a 23x44 array of 4x4x22 mm3 of LYSO crystals arranged in an Anger-logic detector design. The hardware coincidence-timing window for this scanner is set at 4 ns and delayed coincidence window technique is used to estimate the random coincidences in collected data. In this study the performance characteristics of PET/CT scanner were measured as part of the program tests of acceptance for clinical use.Methodology. The performance characteristics of CT scanner were evaluated by manufacturer protocol using Philips system performance phantom. Some additional geometrical tests were performed by the user. The intrinsic measurements of energy resolution as well as timing resolution, which define the TOF performance of PET scanner, were performed following the recommendations of manufacturer using 18 F. Spatial resolution, sensitivity, scatter fraction, counting rate performance, image quality and accuracy were measured according to the NEMA NU-2 2007 procedures. Additionally, to characterize the effect of TOF reconstruction on lesion contrast and noise, the standard NEMA torso phantom was reconstructed with and without TOF capability. The accuracy of PET/CT image registration was tested according to the manufacturer protocol using an image alignment calibration holder with 6 point sources of 22

  10. Tuning Ce distribution for high performanced Nd-Ce-Fe-B sintered magnets

    Energy Technology Data Exchange (ETDEWEB)

    Fan, Xiaodong [School of Materials Science and Engineering, Xi’an University of Technology, Xi’an 710048 (China); Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Science, Ningbo 315201 (China); Guo, Shuai; Chen, Kan; Chen, Renjie; Lee, Don [Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Science, Ningbo 315201 (China); You, Caiyin, E-mail: caiyinyou@xaut.edu.cn [School of Materials Science and Engineering, Xi’an University of Technology, Xi’an 710048 (China); Yan, Aru, E-mail: aruyan@nimte.ac.cn [Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Science, Ningbo 315201 (China)

    2016-12-01

    A dual-alloy method was applied to tune the distribution of Ce for enhancing the performance of Nd-Ce-Fe-B sintered magnets with a nominal composition of (Nd{sub 0.75}Ce{sub 0.25}){sub 30.5}Fe{sub bal}Al{sub 0.1}Cu{sub 0.1}B. In comparison to the single alloy of (Nd{sub 0.75}Ce{sub 0.25}){sub 30.5}Fe{sub bal}Al{sub 0.1}Cu{sub 0.1}B, the coercivity was enhanced from 10.3 kOe to 12.1 kOe and the remanence was increased from 13.1 kG to 13.3 kG for the magnets with a dual-alloy method. In addition, the remanence temperature coefficient α and coercivity temperature coefficient β were also slightly improved for the magnet with the dual alloys. The results of microstructure characterizations show the uniform distribution of Ce for the magnet with a single alloy, and the coexistence of the Ce-rich and Ce-lean regions for the magnet with the dual alloys. In combinations with the nucleation of reversal domains and magnetic recoil curves, the property enhancement of magnets with a dual-alloy method was well explained. - Highlights: • Improved magnetic properties were obtained in dual-alloy magnet. • This is due to the tuning of Ce distribution and the change in microstructure. • The magnetic hardening effect can be observed in dual-alloy magnet.

  11. Cuckoo search with Lévy flights for weighted Bayesian energy functional optimization in global-support curve data fitting.

    Science.gov (United States)

    Gálvez, Akemi; Iglesias, Andrés; Cabellos, Luis

    2014-01-01

    The problem of data fitting is very important in many theoretical and applied fields. In this paper, we consider the problem of optimizing a weighted Bayesian energy functional for data fitting by using global-support approximating curves. By global-support curves we mean curves expressed as a linear combination of basis functions whose support is the whole domain of the problem, as opposed to other common approaches in CAD/CAM and computer graphics driven by piecewise functions (such as B-splines and NURBS) that provide local control of the shape of the curve. Our method applies a powerful nature-inspired metaheuristic algorithm called cuckoo search, introduced recently to solve optimization problems. A major advantage of this method is its simplicity: cuckoo search requires only two parameters, many fewer than other metaheuristic approaches, so the parameter tuning becomes a very simple task. The paper shows that this new approach can be successfully used to solve our optimization problem. To check the performance of our approach, it has been applied to five illustrative examples of different types, including open and closed 2D and 3D curves that exhibit challenging features, such as cusps and self-intersections. Our results show that the method performs pretty well, being able to solve our minimization problem in an astonishingly straightforward way.

  12. Non-parametric Tuning of PID Controllers A Modified Relay-Feedback-Test Approach

    CERN Document Server

    Boiko, Igor

    2013-01-01

    The relay feedback test (RFT) has become a popular and efficient  tool used in process identification and automatic controller tuning. Non-parametric Tuning of PID Controllers couples new modifications of classical RFT with application-specific optimal tuning rules to form a non-parametric method of test-and-tuning. Test and tuning are coordinated through a set of common parameters so that a PID controller can obtain the desired gain or phase margins in a system exactly, even with unknown process dynamics. The concept of process-specific optimal tuning rules in the nonparametric setup, with corresponding tuning rules for flow, level pressure, and temperature control loops is presented in the text.   Common problems of tuning accuracy based on parametric and non-parametric approaches are addressed. In addition, the text treats the parametric approach to tuning based on the modified RFT approach and the exact model of oscillations in the system under test using the locus of a perturbedrelay system (LPRS) meth...

  13. Lessons after 3 years of running GENIUS-TF in Gran Sasso

    Energy Technology Data Exchange (ETDEWEB)

    Krivosheina, I V; Klapdor-Kleingrothaus, H V [Max-Planck-Institut fuer Kernphysik, PO 10 39 80, D-69029 Heidelberg (Germany)

    2006-10-01

    After operation of GENIUS-TF over 3 years with finally six naked Ge detectors (15 kg) in liquid nitrogen in Gran Sasso, we realize serious problems for realization of a full-size GENIUS-like experiment: (i) background from {sup 222}Rn diffusing into the setup, on a level far beyond the expectation. (ii) Limited long-term stability of naked detectors in liquid nitrogen. None of the six detectors is running after 3 years with the nominal high voltage. Three of the six detectors do not work at all any more. The HDMS (Heidelberg Dark Matter Search) setup at LNGS, operates the first enriched {sup 73}Ge detector worldwide, and looks for spin-dependent WIMP-nucleon coupling at the Gran Sasso Underground Laboratory. The results (85.48 kg d) improve the best present existing limits on the WIMP-neutron spin-dependent cross-section (obtained from {sup 129}Xe) for low WIMP masses (Klapdor-Kleingrothaus et al 2005 Phys. Lett. B 609 226-31)

  14. Comparison of the Efficiency of Tuned Mass and Tuned Liquid Dampers at High-Rise Structures under Near and Far Fault Earthquakes

    Directory of Open Access Journals (Sweden)

    Hamed Rahman Shokrgozar

    2017-02-01

    Full Text Available Tuned mass and tuned liquid dampers are most common passive control systems that used for decrease of seismic responses of buildings. In this study, the performance of high-rise buildings with TM and TL dampers are evaluated under seven near-fault and seven far-fault earthquakes. For this purpose, a twenty-four stories steel moment frame building has been considered and the time history dynamic analyses are performed for both of controlled and uncontrolled states. Moreover, this building has been also modelled with five various mass, stiffness and damping ratios.The results have been shown that decreasing the structural responses at tall buildings against near-fault earthquakes are more than far-fault earthquakes due to the effect of higher modes. Furthermore, the tuned mass damper has better performance at decreasing of the responses in comparison of tuned liquid dampers.

  15. Broad electrical tuning of plasmonic nanoantennas at visible frequencies

    Energy Technology Data Exchange (ETDEWEB)

    Hoang, Thang B. [Department of Physics, Duke University, Durham, North Carolina 27708 (United States); Center for Metamaterials and Integrated Plasmonics, Duke University, Durham, North Carolina 27708 (United States); Mikkelsen, Maiken H., E-mail: m.mikkelsen@duke.edu [Department of Physics, Duke University, Durham, North Carolina 27708 (United States); Center for Metamaterials and Integrated Plasmonics, Duke University, Durham, North Carolina 27708 (United States); Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina 27708 (United States)

    2016-05-02

    We report an experimental demonstration of electrical tuning of plasmon resonances of optical nanopatch antennas over a wide wavelength range. The antennas consist of silver nanocubes separated from a gold film by a thin 8 nm polyelectrolyte spacer layer. By using ionic liquid and indium tin oxide coated glass as a top electrode, we demonstrate dynamic and reversible tuning of the plasmon resonance over 100 nm in the visible wavelength range using low applied voltages between −3.0 V and 2.8 V. The electrical potential is applied across the nanoscale gap causing changes in the gap thickness and dielectric environment which, in turn, modifies the plasmon resonance. The observed tuning range is greater than the full-width-at-half-maximum of the plasmon resonance, resulting in a tuning figure of merit of 1.05 and a tuning contrast greater than 50%. Our results provide an avenue to create active and reconfigurable integrated nanophotonic components for applications in optoelectronics and sensing.

  16. Measurement of Beam Tunes in the Tevatron Using the BBQ System

    Energy Technology Data Exchange (ETDEWEB)

    Edstrom, Dean R.; /Indiana U.

    2009-04-01

    Measuring the betatron tunes in any synchrotron is of critical importance to ensuring the stability of beam in the synchrotron. The Base Band Tune, or BBQ, measurement system was developed by Marek Gasior of CERN and has been installed at Brookhaven and Fermilab as a part of the LHC Accelerator Research Program, or LARP. The BBQ was installed in the Tevatron to evaluate its effectiveness at reading proton and antiproton tunes at its flattop energy of 980 GeV. The primary objectives of this thesis are to examine the methods used to measure the tune using the BBQ tune measurement system, to incorporate the system into the Fermilab accelerator controls system, ACNET, and to compare the BBQ to existing tune measurement systems in the Tevatron.

  17. Measurement of Beam Tunes in the Tevatron Using the BBQ System

    International Nuclear Information System (INIS)

    Edstrom, Dean R.

    2009-01-01

    Measuring the betatron tunes in any synchrotron is of critical importance to ensuring the stability of beam in the synchrotron. The Base Band Tune, or BBQ, measurement system was developed by Marek Gasior of CERN and has been installed at Brookhaven and Fermilab as a part of the LHC Accelerator Research Program, or LARP. The BBQ was installed in the Tevatron to evaluate its effectiveness at reading proton and antiproton tunes at its flattop energy of 980 GeV. The primary objectives of this thesis are to examine the methods used to measure the tune using the BBQ tune measurement system, to incorporate the system into the Fermilab accelerator controls system, ACNET, and to compare the BBQ to existing tune measurement systems in the Tevatron

  18. Application of Evolutionary Computation in Automotive Powertrain Mount Tuning

    Directory of Open Access Journals (Sweden)

    Anab Akanda

    2006-01-01

    Full Text Available Engine mount tuning is a multi-disciplinary exercise since it affects Idle-shake, Road-shake and power-train noise response. Engine inertia is often used as a tuned absorber for controlling suspension resonance related road-shake issues. Last but not least, vehicle ride and handling may also be affected by mount tuning. In this work, Torque-Roll-Axis (TRA decoupling of the rigid powertrain was used as a starting point for mount tuning. Nodal point of flexible powertrain bending was used to define the envelop for transmission mount locations. The frequency corresponding to the decoupled roll mode of the rigid powertrain was then adjusted for idle-shake and road-shake response management.

  19. Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3'-digallate (TF3

    Directory of Open Access Journals (Sweden)

    Chia-Nan Chen

    2005-01-01

    Full Text Available SARS-CoV is the causative agent of severe acute respiratory syndrome (SARS. The virally encoded 3C-like protease (3CLPro has been presumed critical for the viral replication of SARS-CoV in infected host cells. In this study, we screened a natural product library consisting of 720 compounds for inhibitory activity against 3CLPro. Two compounds in the library were found to be inhibitive: tannic acid (IC50 = 3 µM and 3-isotheaflavin-3-gallate (TF2B (IC50 = 7 µM. These two compounds belong to a group of natural polyphenols found in tea. We further investigated the 3CLPro-inhibitory activity of extracts from several different types of teas, including green tea, oolong tea, Puer tea and black tea. Our results indicated that extracts from Puer and black tea were more potent than that from green or oolong teas in their inhibitory activities against 3CLPro. Several other known compositions in teas were also evaluated for their activities in inhibiting 3CLPro. We found that caffeine, (—-epigallocatechin gallte (EGCg, epicatechin (EC, theophylline (TP, catechin (C, epicatechin gallate (ECg and epigallocatechin (EGC did not inhibit 3CLPro activity. Only theaflavin-3,3′-digallate (TF3 was found to be a 3CLPro inhibitor. This study has resulted in the identification of new compounds that are effective 3CLPro inhibitors.

  20. Proposals for cold testing of the ITER TF coils

    International Nuclear Information System (INIS)

    Libeyre, P.; Ciazynski, D.; Dolgetta, N.; Duchateau, J.L.; Lyraud, C.; Kircher, F.; Schild, T.; Fietz, W.H.; Zahn, G.

    2005-01-01

    The ITER Toroidal Field (TF) magnet system will be made of 18 coils using Nb 3 Sn as superconducting material. These coils will operate at a maximum field of 11.8 T for a nominal current of 68 kA carried by a dual channel cable-in-conduit conductor cooled by a forced flow of supercritical helium at 4.5 K. In each coil, seven 760 m conductor lengths wound in double pancakes will be connected to each other by low resistance joints. As a final step of the reception tests, it is proposed to perform cold tests of these coils at liquid helium temperature after completion of their manufacture. The testing shall include high voltage tests to check the quality of the insulation, leak tests and pressure drop measurements of the hydraulic circuits as well as measurement of the joint resistances. Testing the coils up to nominal current is a discussed option, addressing on one hand measurement of the electrical performances in self field and on the other hand the mechanical behaviour of the coils. To perform these tests, a dedicated test facility has to be built, allowing possible simultaneous testing of two coils, assembled together in a twin coil configuration, similarly to their assembly in the torus. (authors)

  1. Proposals for cold testing of the ITER TF coils

    Energy Technology Data Exchange (ETDEWEB)

    Libeyre, P.; Ciazynski, D.; Dolgetta, N.; Duchateau, J.L.; Lyraud, C. [Association Euratom/CEA Cadarache, Dept. de Recherches sur la Fusion Controlee (DRFC), 13 - Saint-Paul-lez-Durance (France); Kircher, F.; Schild, T. [CEA Saclay, Dept. d' Astrophysique, de Physique des Particules, de Physique Nucleaire et de l' Instrumentation Associee, 91- Gif sur Yvette (France); Fietz, W.H.; Zahn, G. [Association Euratom-Forschungszentrum Karlsruhe, Karlsruhe (Germany)

    2005-07-01

    The ITER Toroidal Field (TF) magnet system will be made of 18 coils using Nb{sub 3}Sn as superconducting material. These coils will operate at a maximum field of 11.8 T for a nominal current of 68 kA carried by a dual channel cable-in-conduit conductor cooled by a forced flow of supercritical helium at 4.5 K. In each coil, seven 760 m conductor lengths wound in double pancakes will be connected to each other by low resistance joints. As a final step of the reception tests, it is proposed to perform cold tests of these coils at liquid helium temperature after completion of their manufacture. The testing shall include high voltage tests to check the quality of the insulation, leak tests and pressure drop measurements of the hydraulic circuits as well as measurement of the joint resistances. Testing the coils up to nominal current is a discussed option, addressing on one hand measurement of the electrical performances in self field and on the other hand the mechanical behaviour of the coils. To perform these tests, a dedicated test facility has to be built, allowing possible simultaneous testing of two coils, assembled together in a twin coil configuration, similarly to their assembly in the torus. (authors)

  2. Fine-tuning and the stability of recurrent neural networks.

    Directory of Open Access Journals (Sweden)

    David MacNeil

    Full Text Available A central criticism of standard theoretical approaches to constructing stable, recurrent model networks is that the synaptic connection weights need to be finely-tuned. This criticism is severe because proposed rules for learning these weights have been shown to have various limitations to their biological plausibility. Hence it is unlikely that such rules are used to continuously fine-tune the network in vivo. We describe a learning rule that is able to tune synaptic weights in a biologically plausible manner. We demonstrate and test this rule in the context of the oculomotor integrator, showing that only known neural signals are needed to tune the weights. We demonstrate that the rule appropriately accounts for a wide variety of experimental results, and is robust under several kinds of perturbation. Furthermore, we show that the rule is able to achieve stability as good as or better than that provided by the linearly optimal weights often used in recurrent models of the integrator. Finally, we discuss how this rule can be generalized to tune a wide variety of recurrent attractor networks, such as those found in head direction and path integration systems, suggesting that it may be used to tune a wide variety of stable neural systems.

  3. Improving Convergence of Iterative Feedback Tuning using Optimal External Perturbations

    DEFF Research Database (Denmark)

    Huusom, Jakob Kjøbsted; Hjalmarsson, Håkon; Poulsen, Niels Kjølstad

    2008-01-01

    Iterative feedback tuning constitutes an attractive control loop tuning method for processes in the absence of sufficient process insight. It is a purely data driven approach to optimization of the loop performance. The standard formulation ensures an unbiased estimate of the loop performance cost...... function gradient, which is used in a search algorithm. A slow rate of convergence of the tuning method is often experienced when tuning for disturbance rejection. This is due to a poor signal to noise ratio in the process data. A method is proposed for increasing the information content in data...

  4. Evaluation of Controller Tuning Methods Applied to Distillation Column Control

    DEFF Research Database (Denmark)

    Nielsen, Kim; W. Andersen, Henrik; Kümmel, Professor Mogens

    A frequency domain approach is used to compare the nominal performance and robustness of dual composition distillation column control tuned according to Ziegler-Nichols (ZN) and Biggest Log Modulus Tuning (BLT) for three binary distillation columns, WOBE, LUVI and TOFA. The scope of this is to ex......A frequency domain approach is used to compare the nominal performance and robustness of dual composition distillation column control tuned according to Ziegler-Nichols (ZN) and Biggest Log Modulus Tuning (BLT) for three binary distillation columns, WOBE, LUVI and TOFA. The scope...

  5. Tuning of PID load frequency controller for power systems

    International Nuclear Information System (INIS)

    Tan Wen

    2009-01-01

    PID tuning of load frequency controllers for power systems is discussed in this paper. The tuning method is based on a two-degree-of-freedom internal model control (IMC) design method, and the performance of the resulting PID controller is related to two tuning parameters thus detuning is easy when necessary. Then an anti-GRC scheme is proposed to overcome the generation rate constraints. Finally, the method is extended to two-area cases.

  6. A Tuned Single Parameter for Representing Conjunction Risk

    Science.gov (United States)

    Plakaloic, D.; Hejduk, M. D.; Frigm, R. C.; Newman, L. K.

    2011-01-01

    Satellite conjunction assessment risk analysis is a subjective enterprise that can benefit from quantitative aids and, to this end, NASA/GSFC has developed a fuzzy logic construct - called the F-value - to attempt to provide a statement of conjunction risk that amalgamates multiple indices and yields a more stable intra-event assessment. This construct has now sustained an extended tuning procedure against heuristic analyst assessment of event risk. The tuning effort has resulted in modifications to the calculation procedure and the adjustment of tuning coefficients, producing a construct with both more predictive force and a better statement of its error.

  7. Utilization of Short-Simulations for Tuning High-Resolution Climate Model

    Science.gov (United States)

    Lin, W.; Xie, S.; Ma, P. L.; Rasch, P. J.; Qian, Y.; Wan, H.; Ma, H. Y.; Klein, S. A.

    2016-12-01

    Many physical parameterizations in atmospheric models are sensitive to resolution. Tuning the models that involve a multitude of parameters at high resolution is computationally expensive, particularly when relying primarily on multi-year simulations. This work describes a complementary set of strategies for tuning high-resolution atmospheric models, using ensembles of short simulations to reduce the computational cost and elapsed time. Specifically, we utilize the hindcast approach developed through the DOE Cloud Associated Parameterization Testbed (CAPT) project for high-resolution model tuning, which is guided by a combination of short (tests have been found to be effective in numerous previous studies in identifying model biases due to parameterized fast physics, and we demonstrate that it is also useful for tuning. After the most egregious errors are addressed through an initial "rough" tuning phase, longer simulations are performed to "hone in" on model features that evolve over longer timescales. We explore these strategies to tune the DOE ACME (Accelerated Climate Modeling for Energy) model. For the ACME model at 0.25° resolution, it is confirmed that, given the same parameters, major biases in global mean statistics and many spatial features are consistent between Atmospheric Model Intercomparison Project (AMIP)-type simulations and CAPT-type hindcasts, with just a small number of short-term simulations for the latter over the corresponding season. The use of CAPT hindcasts to find parameter choice for the reduction of large model biases dramatically improves the turnaround time for the tuning at high resolution. Improvement seen in CAPT hindcasts generally translates to improved AMIP-type simulations. An iterative CAPT-AMIP tuning approach is therefore adopted during each major tuning cycle, with the former to survey the likely responses and narrow the parameter space, and the latter to verify the results in climate context along with assessment in

  8. A precision study of the fine tuning in the DiracNMSSM

    International Nuclear Information System (INIS)

    Kaminska, Anna; Ross, Graham G.; Staub, Florian; Bonn Univ.

    2014-01-01

    Recently the DiracNMSSM has been proposed as a possible solution to reduce the fine tuning in supersymmetry. We determine the degree of fine tuning needed in the DiracNMSSM with and without non-universal gaugino masses and compare it with the fine tuning in the GNMSSM. To apply reasonable cuts on the allowed parameter regions we perform a precise calculation of the Higgs mass. In addition, we include the limits from direct SUSY searches and dark matter abundance. We find that both models are comparable in terms of fine tuning, with the minimal fine tuning in the GNMSSM slightly smaller.

  9. Tune space manipulations in jumping depolarizing resonances

    International Nuclear Information System (INIS)

    Ratner, L.G.; Ahrens, L.A.

    1987-01-01

    In February 1986, the AGS polarized beam reached a momentum of 22 GeV/c with a 45% polarization and an intensity of 1 to 2 x 10 10 polarized protons per pulse at a repetition rate of 2.1 seconds. In order to achieve this, one had to overcome the effect of some 40 depolarizing resonances. In our first commissioning run in 1984, we had reached 16.5 GeV/c using, with suitable modifications, the conventional techniques first used at the Argonne ZGS. This worked well, but we found that the fast tune shifts required to cross the intrinsic depolarizing resonances were causing an increase in beam emittance which led to the need for stronger corrections later in the cycle and to diminished extraction efficiency. For the 1986 run, we were prepared to minimize this emittance growth by the application of slow quadrupole pulses to change the region in tune space in which we operated the first tune quads. In this paper we give a brief description of the conventional corrections, but our main emphasis is on the descriptions of tune space manipulations

  10. A digital multi-channel spectroscopy system with 100 MHz flash ADC module for the GENIUS-TF and GENIUS projects

    International Nuclear Information System (INIS)

    Kihm, T.; Bobrakov, V.F.; Klapdor-Kleingrothaus, H.V.

    2003-01-01

    In this paper we present the first results of applying a digital processing technology in low-level gamma spectroscopy with HPGE detectors. An experimental gamma spectrometer using Flash ADC module is built and tested. The test system is now under development and shows major advantages over the traditional analog technologies. It will be installed for the GENIUS-TF and GENIUS projects in Gran-Sasso in early 2003

  11. Improving the computation efficiency of COBRA-TF for LWR safety analysis of large problems

    International Nuclear Information System (INIS)

    Cuervo, D.; Avramova, M. N.; Ivanov, K. N.

    2004-01-01

    A matrix solver is implemented in COBRA-TF in order to improve the computation efficiency of both numerical solution methods existing in the code, the Gauss elimination and the Gauss-Seidel iterative technique. Both methods are used to solve the system of pressure linear equations and relay on the solution of large sparse matrices. The introduced solver accelerates the solution of these matrices in cases of large number of cells. The execution time is reduced in half as compared to the execution time without using matrix solver for the cases with large matrices. The achieved improvement and the planned future work in this direction are important for performing efficient LWR safety analyses of large problems. (authors)

  12. A novel tuning approach for offset-free MPC

    DEFF Research Database (Denmark)

    Waschl, Harald; Jørgensen, John Bagterp; Huusom, Jakob Kjøbsted

    2015-01-01

    , if a nominal plant and overall objective are known, the tuning can become straightforward. However, as soon as disturbances have to be taken into account, the tuning effort increases and becomes less intuitive. Against this background, a novel strategy to address the issues with unknown disturbances...

  13. Accurate automatic tuning circuit for bipolar integrated filters

    NARCIS (Netherlands)

    de Heij, Wim J.A.; de Heij, W.J.A.; Hoen, Klaas; Hoen, Klaas; Seevinck, Evert; Seevinck, E.

    1990-01-01

    An accurate automatic tuning circuit for tuning the cutoff frequency and Q-factor of high-frequency bipolar filters is presented. The circuit is based on a voltage controlled quadrature oscillator (VCO). The frequency and the RMS (root mean square) amplitude of the oscillator output signal are

  14. Automatic Tuning of Control Parameters for Single Speed Engines

    OpenAIRE

    Olsson, Johan

    2004-01-01

    In Scania’s single speed engines for industrial and marine use, the engine speed is controlled by a PI-controller. This controller is tuned independent of engine type and application. This brings certain disadvantages since the engines are used in a wide range of applications where the dynamics may differ. In this thesis, the possibility to tune the controller automatically for a specific engine installation has been investigated. The work shows that automatic tuning is possible. By performin...

  15. Required accuracy of tune measurement and parametrization of chromaticity control

    International Nuclear Information System (INIS)

    Maas, R.

    1991-02-01

    The betatron tunes v x and v y will be measured by Fourier-analyzing a BPM signal generated by a beam which received a fast ( kick /f rev ) equals the fractional part of the tune, a beam blow-up can be observed. In this note the required accuracy of such a tune measurement is discussed. (author). 6 schemes

  16. Performance-based parameter tuning method of model-driven PID control systems.

    Science.gov (United States)

    Zhao, Y M; Xie, W F; Tu, X W

    2012-05-01

    In this paper, performance-based parameter tuning method of model-driven Two-Degree-of-Freedom PID (MD TDOF PID) control system has been proposed to enhance the control performances of a process. Known for its ability of stabilizing the unstable processes, fast tracking to the change of set points and rejecting disturbance, the MD TDOF PID has gained research interest recently. The tuning methods for the reported MD TDOF PID are based on internal model control (IMC) method instead of optimizing the performance indices. In this paper, an Integral of Time Absolute Error (ITAE) zero-position-error optimal tuning and noise effect minimizing method is proposed for tuning two parameters in MD TDOF PID control system to achieve the desired regulating and disturbance rejection performance. The comparison with Two-Degree-of-Freedom control scheme by modified smith predictor (TDOF CS MSP) and the designed MD TDOF PID tuned by the IMC tuning method demonstrates the effectiveness of the proposed tuning method. Copyright © 2012 ISA. Published by Elsevier Ltd. All rights reserved.

  17. Tune measurements with high intensity ion beams at GSI SIS-18

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Rahul [GSI, Darmstadt (Germany); TEMF, TU Darmstadt (Germany); Forck, Peter; Kowina, Piotr; Kaufmann, Wolfgang [GSI, Darmstadt (Germany); Weiland, Thomas [TEMF, TU Darmstadt (Germany)

    2012-07-01

    A precise tune measurement during a full accelerating cycle is required to achieve stable high current operation. A new system has been commissioned at GSI for position, orbit and tune measurements. It consists of three distinct parts; an exciter which provides power to excite coherent betatron oscillations in the bunched beam; Fast ADCs to digitize the BPM signals at 125 MSa/s; the post processing electronics uses digitized BPM signals to acquire one position value per bunch. Subsequently the baseband tune is determined by Fourier transformation of the position data. Experiments were conducted to understand the effects of high beam intensity on tune at injection plateau (11.4 MeV/u) and during acceleration ramp (11.4-600 MeV/u). These experiments were performed with U{sup 73+} and Ar{sup 18+} ion beam at highest achievable intensities of 2.10{sup 9} and 2.5.10{sup 10} respectively. Tune shift with increased intensity was observed. The working principle of the tune measurement system and observed high intensity effects on tune will be reported in this contribution.

  18. Self-Tuning Speed Regulator for CVC Induction Motor Drive

    DEFF Research Database (Denmark)

    Bidstrup, N.; Rasmussen, Henrik; Knudsen, Torben

    1994-01-01

    A self-tuning speed regulator for a current vector controlled induction motor drive has been designed.......A self-tuning speed regulator for a current vector controlled induction motor drive has been designed....

  19. Tune modulation due to synchrotron oscillations and chromaticity, and the dynamic aperture

    International Nuclear Information System (INIS)

    Parzen, G.

    1995-01-01

    A tracking study was done of the effects of a tune modulations, due to synchrotron oscillations and the tune dependence on momentum (chromaticity), on the dynamic aperture. The studies were done using several RHIC lattices and tracking runs of about 1 x 10 6 turns. The dynamic aperture was found to decrease roughly linearly with the amplitude of the tune modulation. Lower order non-linear resonances, like the 1/3 and 1/4 resonance are not crossed because of the tune modulation. Three different cases were studied, corresponding to RHIC lattices with different β*, and with different synchrotron oscillation amplitudes. In each case, the tune modulation amplitude was varied by changing the chromaticity. In each case, roughly the same result, was found. The result found here for the effect of a tune modulation due to chromaticity may be compared with the result found for the effect of a tune modulation due to a gradient ripple in the quadrupoles. The effect of a tune modulation due to a gradient ripple appears to be about 4 times stronger than the effect of a tune modulation due to chromaticity and synchrotron oscillations

  20. Tuned sources of submillimetre radiation

    International Nuclear Information System (INIS)

    Berezhnyj, V.L.

    1981-01-01

    The main present directions of development of sources of frequency coherent tuned radiation of electromagnetic waves in the submillimeter range: nonlinear mixing of different frequencies; semiconductor lasers; molecular lasers with optical pumping; relativistic electron beams in a magnetic field as submillimeter radiation sources; submillimeter radiation sources on the basis of SHF classical electrovacuum devices - are considered. The designs of generator systems and their specifications are presented. The main parameters of electromagnetic radiation of different sources, such as: power, stability, frequency, tuning range - are presented. The methods of improving sources and electromagnetic radiation parameters are proposed. The examples of possible applications of submillimeter radiation in different spheres of science and technology are given [ru

  1. Driving the Power of AIX Performance Tuning on IBM Power

    CERN Document Server

    Milberg, Ken

    2009-01-01

    A concise reference for IT professionals, this book goes beyond the rules and contains the best practices and strategies for solid tuning methodology. Tips based on years of experience from an AIX tuning master show specific steps for monitoring and tuning CPU, virtual memory, disk I/O, and network components. Also offering techniques for tuning Oracle and Linux structures that run on an IBM power system-as well as for the new AIX 6.1-this manual discusses what tools are available, how to best use them to collect historical data, and when to analyze trends and results. The only comprehensive,

  2. Historic Learning Approach for Auto-tuning OpenACC Accelerated Scientific Applications

    KAUST Repository

    Siddiqui, Shahzeb

    2015-04-17

    The performance optimization of scientific applications usually requires an in-depth knowledge of the hardware and software. A performance tuning mechanism is suggested to automatically tune OpenACC parameters to adapt to the execution environment on a given system. A historic learning based methodology is suggested to prune the parameter search space for a more efficient auto-tuning process. This approach is applied to tune the OpenACC gang and vector clauses for a better mapping of the compute kernels onto the underlying architecture. Our experiments show a significant performance improvement against the default compiler parameters and drastic reduction in tuning time compared to a brute force search-based approach.

  3. A digital multi-channel spectroscopy system with 100 MHz flash ADC module for the GENIUS-TF and GENIUS projects

    OpenAIRE

    Kihm, T.; Bobrakov, V. F.; Klapdor-Kleingrothaus, H. V.

    2003-01-01

    In this paper we will present the first results of applying a digital processing technology in low-level gamma spectroscopy with HPGE detectors. An experimental gamma spectrometer using Flash ADC module is built and tested. The test system is now under development and shows major advantages over the traditional analog technologies. It will be installed for the GENIUS-TF and GENIUS projects in Gran-Sasso in early 2003.

  4. Tuning of gravity-dependent and gravity-independent vertical angular VOR gain changes by frequency of adaptation.

    Science.gov (United States)

    Yakushin, Sergei B

    2012-06-01

    The gain of the vertical angular vestibulo-ocular reflex (aVOR) was adaptively increased and decreased in a side-down head orientation for 4 h in two cynomolgus monkeys. Adaptation was performed at 0.25, 1, 2, or 4 Hz. The gravity-dependent and -independent gain changes were determined over a range of head orientations from left-side-down to right-side-down at frequencies from 0.25 to 10 Hz, before and after adaptation. Gain changes vs. frequency data were fit with a Gaussian to determine the frequency at which the peak gain change occurred, as well as the tuning width. The frequency at which the peak gravity-dependent gain change occurred was approximately equal to the frequency of adaptation, and the width increased monotonically with increases in the frequency of adaptation. The gravity-independent component was tuned to the adaptive frequency of 0.25 Hz but was uniformly distributed over all frequencies when the adaptation frequency was 1-4 Hz. The amplitude of the gravity-independent gain changes was larger after the aVOR gain decrease than after the gain increase across all tested frequencies. For the aVOR gain decrease, the phase lagged about 4° for frequencies below the adaptation frequency and led for frequencies above the adaptation frequency. For gain increases, the phase relationship as a function of frequency was inverted. This study demonstrates that the previously described dependence of aVOR gain adaptation on frequency is a property of the gravity-dependent component of the aVOR only. The gravity-independent component of the aVOR had a substantial tuning curve only at an adaptation frequency of 0.25 Hz.

  5. Demonstration of thin film pair distribution function analysis (tfPDF for the study of local structure in amorphous and crystalline thin films

    Directory of Open Access Journals (Sweden)

    Kirsten M. Ø. Jensen

    2015-09-01

    Full Text Available By means of normal-incidence, high-flux and high-energy X-rays, total scattering data for pair distribution function (PDF analysis have been obtained from thin films (tf, suitable for local structure analysis. By using amorphous substrates as support for the films, the standard Rapid Acquisition PDF setup can be applied and the scattering signal from the film can be isolated from the total scattering data through subtraction of an independently measured background signal. No angular corrections to the data are needed, as would be the case for grazing incidence measurements. The `tfPDF' method is illustrated through studies of as-deposited (i.e. amorphous and crystalline FeSb3 films, where the local structure analysis gives insight into the stabilization of the metastable skutterudite FeSb3 phase. The films were prepared by depositing ultra-thin alternating layers of Fe and Sb, which interdiffuse and after annealing crystallize to form the FeSb3 structure. The tfPDF data show that the amorphous precursor phase consists of corner-sharing FeSb6 octahedra with motifs highly resembling the local structure in crystalline FeSb3. Analysis of the amorphous structure allows the prediction of whether the final crystalline product will form the FeSb3 phase with or without excess Sb present. The study thus illustrates how analysis of the local structure in amorphous precursor films can help to understand crystallization processes of metastable phases and opens for a range of new local structure studies of thin films.

  6. Double-tuned radiofrequency coil for (19)F and (1)H imaging.

    Science.gov (United States)

    Otake, Yosuke; Soutome, Yoshihisa; Hirata, Koji; Ochi, Hisaaki; Bito, Yoshitaka

    2014-01-01

    We developed a double-tuned radiofrequency (RF) coil using a novel circuit method to double tune for fluorine-19 (19F) and 1H magnetic resonance imaging, whose frequencies are very close to each other. The RF coil consists of 3 parallel-connected series inductor capacitor circuits. A computer simulation for our double-tuned RF coil with a phantom demonstrated that the coil has tuned resonant frequency and high sensitivity for both 19F and 1H. Drug distribution was visualized at 7 tesla using this RF coil and a rat administered perfluoro 15-crown-5-ether emulsion. The double-tune RF coil we developed may be a powerful tool for 19F and 1H imaging.

  7. AUTOMOTIVE DIESEL MAINTENANCE 1. UNIT VII, ENGINE TUNE-UP--DETROIT DIESEL ENGINE.

    Science.gov (United States)

    Human Engineering Inst., Cleveland, OH.

    THIS MODULE OF A 30-MODULE COURSE IS DESIGNED TO DEVELOP AN UNDERSTANDING OF TUNE-UP PROCEDURES FOR DIESEL ENGINES. TOPICS ARE SCHEDULING TUNE-UPS, AND TUNE-UP PROCEDURES. THE MODULE CONSISTS OF A SELF-INSTRUCTIONAL BRANCH PROGRAMED TRAINING FILM "ENGINE TUNE-UP--DETROIT DIESEL ENGINE" AND OTHER MATERIALS. SEE VT 005 655 FOR FURTHER INFORMATION.…

  8. High-Q perpendicular-biased ferrite-tuned cavity

    International Nuclear Information System (INIS)

    Carlini, R.D.; Thiessen, H.A.; Potter, J.M.

    1983-01-01

    Rapid-cycling proton synchrotrons, such as the proposed LAMPF II accelerator, require approximately 10 MV per turn rf with 17% tuning range near 50 MHz. The traditional approach to ferrite-tuned cavities uses a ferrite which is longitudinally biased (rf magnetic field parallel to bias field). This method leads to unacceptably high losses in the ferrite. At Los Alamos, we are developing a cavity with transverse bias (rf magnetic field perpendicular to the bias field) that makes use of the tensor permeability of the ferrite. Modest power tests of a small (10-cm-dia) quarter-wave singly re-entrant cavity tuned by nickel-zinc ferrites and aluminum-doped garnets indicate that the losses in the ferrite can be made negligible compared with the losses due to the surface resistivity of the copper cavity at power levels from 2 to 200 watts

  9. Tune measurement in the NSLS booster synchrotron

    International Nuclear Information System (INIS)

    Blum, E.B.; Nawrocky, R.

    1993-01-01

    The NSLS booster synchrotron can accelerate an electron beam from approximately 80 to 750 MeV in 0.7 sec. The betatron tunes can change during acceleration by as much as 0.1 units, causing beam loss as they cross resonance lines. Precise measurements with a conventional swept spectrum analyzer have always been difficult because of the rapid variation of tune as the magnets are ramped. We are now using a system based on a Tektronix 3052 digital spectrum analyzer that can obtain a complete frequency spectrum over a 10 MHz bandwidth in 200 μsec. Betatron oscillations are stimulated for the measurements by applying white noise to the beam through stripline electrodes. We will describe the instrumentation, our measurements of tune as a function time during the acceleration cycle, and the resulting improvements to the booster operation

  10. Application of digital beam position processor Libera on tune measurement

    International Nuclear Information System (INIS)

    Zhang Chunhui; Sun Baogen; Cao Yong; Lu Ping; Li Jihao

    2006-01-01

    Digital signal processing (DSP) is widely used in the field of beam diagnostics. Especially, DSP achieves very good performance in beam position signal analysis and betatron tune measurement. In Hefei light source, when beam was excited by narrow-band Gaussian white nose, Libera, a digital beam position processor, was used to process the signals from beam position monitor (BPM), which contained betatron oscillation. Fast Fourier transform (FFT) was applied to finding out betatron resonance frequency, from which the decimal part of betatron oscillation tune was calculated. By this means, the measure of horizontal tune was 3.5352 and the measure of vertical tune is 2.6299. (authors)

  11. Minimization of spin tune spread by matching dispersion prime at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Liu, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Kewisch, J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Huang, H. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-08-31

    At RHIC, the spin polarization is preserved with a pair of Siberian snakes on the oppo- site sides in each ring. The polarized proton beam with finite spin tune spread might cross spin resonances multiple times in two cases, one is when beam going through strong spin intrinsic resonances during acceleration, the other is when sweeping spin flipper’ frequency across the spin tune to flip the direction of spin polarization. The consequence is loss of spin polarization in both cases. Therefore, a scheme of min- imizing the spin tune spread by matching the dispersion primes at the two snakes was introduced based on the fact that the spin tune spread is proportional to the difference of dispersion primes at the two snakes. The scheme was implemented at fixed energies for the spin flipper study and during beam acceleration for better spin polarization transmission efficiency. The effect of minimizing the spin tune spread by matching the dispersion primes was observed and confirmed experimentally. The principle of minimizing the spin tune spread by matching the dispersion primes, the impact on the beam optics, and the effect of a narrower spin tune spread are presented in this report.

  12. Auto-tuning systems for J-PARC LINAC RF cavities

    International Nuclear Information System (INIS)

    Fang, Z.; Kobayashi, T.; Fukui, Y.; Futatsukawa, K.; Michizono, S.; Yamaguchi, S.; Anami, S.; Suzuki, H.; Sato, F.; Shinozaki, S.; Chishiro, E.

    2014-01-01

    The 400-MeV proton linear accelerator (LINAC) at the Japan Proton Accelerator Research Complex (J-PARC) consists of 324-MHz low-β and 972-MHz high-β accelerator sections. From October 2006 to May 2013, only the 324-MHz low-β accelerator section was in operation. From the summer of 2013 the J-PARC LINAC was upgraded by installing the 972-MHz high-β accelerator section, and the proton beam was successfully accelerated to 400 MeV in January 2014. Auto-tuning systems for the J-PARC LINAC RF cavities have been successfully developed. A first generation design, an auto-tuning system using a mechanical tuner controller, was developed and operated for the first 3 years. Then the second-generation auto-tuning system was developed using a new approach to the RF cavity warm-up process, and this was applied to the accelerator operation for the subsequent 4 years. During the RF cavity warm-up process in this system, the mechanical tuner is constantly fixed and the input RF frequency is automatically tuned to the cavity resonance frequency using the FPGA (Field-Programmable Gate Array) of the digital feedback RF control system. After the input power level reaches the required value, input RF frequency tuning is stopped and it is switched to the operation frequency. Then, the mechanical tuner control begins operation. This second-generation auto-tuning system was extremely effective for the 324-MHz cavity operation. However, if we apply this approach to the 972-MHz RF cavities, an interlock due to the RF cavity reflection amplitude occasionally occurs at the end of the warm-up process. In order to solve this problem a third generation novel auto-tuning system was successfully developed in December 2013 and applied to the operation of the J-PARC LINAC, including the 972-MHz ACS RF cavities. During the warm-up process both the mechanical tuner controller and the input RF frequency tuning are in operation, and good matching between the input RF frequency and the RF cavity is

  13. Auto-tuning systems for J-PARC LINAC RF cavities

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Z., E-mail: fang@post.kek.jp [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Kobayashi, T.; Fukui, Y.; Futatsukawa, K.; Michizono, S.; Yamaguchi, S.; Anami, S. [High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Suzuki, H.; Sato, F.; Shinozaki, S.; Chishiro, E. [Japan Atomic Energy Agency (JAEA), 2-4 Shirane Shirakata, Tokai-mura, Naka-gun, Ibaraki 319-1195 (Japan)

    2014-12-11

    The 400-MeV proton linear accelerator (LINAC) at the Japan Proton Accelerator Research Complex (J-PARC) consists of 324-MHz low-β and 972-MHz high-β accelerator sections. From October 2006 to May 2013, only the 324-MHz low-β accelerator section was in operation. From the summer of 2013 the J-PARC LINAC was upgraded by installing the 972-MHz high-β accelerator section, and the proton beam was successfully accelerated to 400 MeV in January 2014. Auto-tuning systems for the J-PARC LINAC RF cavities have been successfully developed. A first generation design, an auto-tuning system using a mechanical tuner controller, was developed and operated for the first 3 years. Then the second-generation auto-tuning system was developed using a new approach to the RF cavity warm-up process, and this was applied to the accelerator operation for the subsequent 4 years. During the RF cavity warm-up process in this system, the mechanical tuner is constantly fixed and the input RF frequency is automatically tuned to the cavity resonance frequency using the FPGA (Field-Programmable Gate Array) of the digital feedback RF control system. After the input power level reaches the required value, input RF frequency tuning is stopped and it is switched to the operation frequency. Then, the mechanical tuner control begins operation. This second-generation auto-tuning system was extremely effective for the 324-MHz cavity operation. However, if we apply this approach to the 972-MHz RF cavities, an interlock due to the RF cavity reflection amplitude occasionally occurs at the end of the warm-up process. In order to solve this problem a third generation novel auto-tuning system was successfully developed in December 2013 and applied to the operation of the J-PARC LINAC, including the 972-MHz ACS RF cavities. During the warm-up process both the mechanical tuner controller and the input RF frequency tuning are in operation, and good matching between the input RF frequency and the RF cavity is

  14. Collective Mind: Towards Practical and Collaborative Auto-Tuning

    Directory of Open Access Journals (Sweden)

    Grigori Fursin

    2014-01-01

    Full Text Available Empirical auto-tuning and machine learning techniques have been showing high potential to improve execution time, power consumption, code size, reliability and other important metrics of various applications for more than two decades. However, they are still far from widespread production use due to lack of native support for auto-tuning in an ever changing and complex software and hardware stack, large and multi-dimensional optimization spaces, excessively long exploration times, and lack of unified mechanisms for preserving and sharing of optimization knowledge and research material. We present a possible collaborative approach to solve above problems using Collective Mind knowledge management system. In contrast with previous cTuning framework, this modular infrastructure allows to preserve and share through the Internet the whole auto-tuning setups with all related artifacts and their software and hardware dependencies besides just performance data. It also allows to gradually structure, systematize and describe all available research material including tools, benchmarks, data sets, search strategies and machine learning models. Researchers can take advantage of shared components and data with extensible meta-description to quickly and collaboratively validate and improve existing auto-tuning and benchmarking techniques or prototype new ones. The community can now gradually learn and improve complex behavior of all existing computer systems while exposing behavior anomalies or model mispredictions to an interdisciplinary community in a reproducible way for further analysis. We present several practical, collaborative and model-driven auto-tuning scenarios. We also decided to release all material at c-mind.org/repo to set up an example for a collaborative and reproducible research as well as our new publication model in computer engineering where experimental results are continuously shared and validated by the community.

  15. Tuning Properties in Silver Clusters

    KAUST Repository

    Joshi, Chakra Prasad

    2015-07-09

    The properties of Ag nanoclusters are not as well understood as those of their more precious Au cousins. However, a recent surge in the exploration of strategies to tune the physicochemical characteristics of Ag clusters addresses this imbalance, leading to new insights into their optical, luminescence, crystal habit, metal-core, ligand-shell and environmental properties. In this Perspective, we provide an overview of the latest strategies along with a brief introduction of the theoretical framework necessary to understand the properties of silver nanoclusters and the basis for their tuning. The advances in cluster research and the future prospects presented in this Perspective will eventually guide the next large systematic study of nanoclusters, resulting in a single collection of data similar to the periodic table of elements.

  16. Tuning Properties in Silver Clusters

    KAUST Repository

    Joshi, Chakra Prasad; Bootharaju, Megalamane Siddaramappa; Bakr, Osman

    2015-01-01

    The properties of Ag nanoclusters are not as well understood as those of their more precious Au cousins. However, a recent surge in the exploration of strategies to tune the physicochemical characteristics of Ag clusters addresses this imbalance, leading to new insights into their optical, luminescence, crystal habit, metal-core, ligand-shell and environmental properties. In this Perspective, we provide an overview of the latest strategies along with a brief introduction of the theoretical framework necessary to understand the properties of silver nanoclusters and the basis for their tuning. The advances in cluster research and the future prospects presented in this Perspective will eventually guide the next large systematic study of nanoclusters, resulting in a single collection of data similar to the periodic table of elements.

  17. Human face processing is tuned to sexual age preferences

    DEFF Research Database (Denmark)

    Ponseti, J; Granert, O; van Eimeren, T

    2014-01-01

    Human faces can motivate nurturing behaviour or sexual behaviour when adults see a child or an adult face, respectively. This suggests that face processing is tuned to detecting age cues of sexual maturity to stimulate the appropriate reproductive behaviour: either caretaking or mating....... In paedophilia, sexual attraction is directed to sexually immature children. Therefore, we hypothesized that brain networks that normally are tuned to mature faces of the preferred gender show an abnormal tuning to sexual immature faces in paedophilia. Here, we use functional magnetic resonance imaging (f......MRI) to test directly for the existence of a network which is tuned to face cues of sexual maturity. During fMRI, participants sexually attracted to either adults or children were exposed to various face images. In individuals attracted to adults, adult faces activated several brain regions significantly more...

  18. Recommendations for the tuning of rare event probability estimators

    International Nuclear Information System (INIS)

    Balesdent, Mathieu; Morio, Jérôme; Marzat, Julien

    2015-01-01

    Being able to accurately estimate rare event probabilities is a challenging issue in order to improve the reliability of complex systems. Several powerful methods such as importance sampling, importance splitting or extreme value theory have been proposed in order to reduce the computational cost and to improve the accuracy of extreme probability estimation. However, the performance of these methods is highly correlated with the choice of tuning parameters, which are very difficult to determine. In order to highlight recommended tunings for such methods, an empirical campaign of automatic tuning on a set of representative test cases is conducted for splitting methods. It allows to provide a reduced set of tuning parameters that may lead to the reliable estimation of rare event probability for various problems. The relevance of the obtained result is assessed on a series of real-world aerospace problems

  19. Towards automatic parameter tuning of stream processing systems

    KAUST Repository

    Bilal, Muhammad

    2017-09-27

    Optimizing the performance of big-data streaming applications has become a daunting and time-consuming task: parameters may be tuned from a space of hundreds or even thousands of possible configurations. In this paper, we present a framework for automating parameter tuning for stream-processing systems. Our framework supports standard black-box optimization algorithms as well as a novel gray-box optimization algorithm. We demonstrate the multiple benefits of automated parameter tuning in optimizing three benchmark applications in Apache Storm. Our results show that a hill-climbing algorithm that uses a new heuristic sampling approach based on Latin Hypercube provides the best results. Our gray-box algorithm provides comparable results while being two to five times faster.

  20. Tuning Stilbene Photochemistry by Fluorination: State Reordering Leads to Sudden Polarization near the Franck-Condon Region.

    Science.gov (United States)

    Ioffe, Ilya N; Quick, Martin; Quick, Michael T; Dobryakov, Alexander L; Richter, Celin; Granovsky, Alex A; Berndt, Falko; Mahrwald, Rainer; Ernsting, Nikolaus P; Kovalenko, Sergey A

    2017-10-25

    Spontaneous polarization of a nonpolar molecule upon photoexcitation (the sudden polarization effect) earlier discussed for 90°-twisted alkenes is observed and calculated for planar ring-fluorinated stilbenes, trans-2,3,5,6,2',3',5',6'-octofluorostilbene (tF2356) and trans-2,3,4,5,6,2',3',4',5',6'-decafluorostilbene (tF23456). Due to the fluorination, Franck-Condon states S 1 FC and S 2 FC are dominated by the quasi-degenerate HOMO-1 → LUMO and HOMO-2 → LUMO excitations, while their interaction gives rise to a symmetry-broken zwitterionic S 1 state. After optical excitation of tF2356, one observes an ultrafast (∼0.06 ps) evolution that reflects relaxation from initial nonpolar S 3 FC to long-lived (1.3 ns in n-hexane and 3.4 ns in acetonitrile) polar S 1 . The polarity of S 1 is evidenced by a solvatochromic shift of its fluorescence band. The experimental results provide a sensitive test for quantum-chemical calculations. In particular, our calculations agree with the experiment, and raise concerns about the applicability of the common TDDFT approach to relatively simple stilbenic systems.

  1. Tuning the DARHT Axis-II linear induction accelerator focusing

    Energy Technology Data Exchange (ETDEWEB)

    Ekdahl, Carl A. [Los Alamos National Laboratory

    2012-04-24

    Flash radiography of large hydrodynamic experiments driven by high explosives is a well-known diagnostic technique in use at many laboratories, and the Dual-Axis Radiography for Hydrodynamic Testing (DARHT) facility at Los Alamos produces flash radiographs of large hydrodynamic experiments. Two linear induction accelerators (LIAs) make the bremsstrahlung radiographic source spots for orthogonal views of each test. The 2-kA, 20-MeV Axis-I LIA creates a single 60-ns radiography pulse. The 1.7-kA, 16.5-MeV Axis-II LIA creates up to four radiography pulses by kicking them out of a longer pulse that has a 1.6-{mu}s flattop. The Axis-II injector, LIA, kicker, and downstream transport (DST) to the bremsstrahlung converter are described. Adjusting the magnetic focusing and steering elements to optimize the electron-beam transport through an LIA is often called 'tuning.' As in all high-current LIAs, the focusing field is designed to be as close to that of the ideal continuous solenoid as physically possible. In ideal continuous solenoidal transport a smoothly varying beam size can easily be found for which radial forces balance, and the beam is said to be 'matched' to the focusing field. A 'mismatched' beam exhibits unwanted oscillations in size, which are a source of free energy that contributes to emittance growth. This is undesirable, because in the absence of beam-target effects, the radiographic spot size is proportional to the emittance. Tuning the Axis-II LIA is done in two steps. First, the solenoidal focusing elements are set to values designed to provide a matched beam with little or no envelope oscillations, and little or no beam-breakup (BBU) instability growth. Then, steering elements are adjusted to minimize the motion of the centroid of a well-centered beam at the LIA exit. This article only describes the design of the tune for the focusing solenoids. The DARHT Axis-II LIA was required to be re-tuned after installing an

  2. Heavy vehicle pitch dynamics and suspension tuning

    OpenAIRE

    Cao, Dongpu; Rakheja, Subhash; Su, Chun-Yi

    2008-01-01

    The influence of suspension tuning of passenger cars on bounce and pitch ride performance has been explored in a number of studies, while only minimal efforts have been made for establishing similar rules for heavy vehicles. This study aims to explore pitch dynamics and suspension tunings of a two-axle heavy vehicle with unconnected suspension, which could also provide valuable information for heavy vehicles with coupled suspensions. Based on a generalised pitch-plane model of a two-axle heav...

  3. Implementation through Innovation: A Literature-Based Analysis of the Tuning Project

    Science.gov (United States)

    Pálvölgyi, Krisztián

    2017-01-01

    Tuning Educational Structures in Europe is perhaps the most important higher education innovation platform nowadays. The main objective of the Tuning Project is to develop a tangible approach to implement the action lines of the Bologna Process; thus, implementation and innovation are closely linked in Tuning. However, during its development,…

  4. Asymmetry of edge plasma turbulence in biasing experiments on tokamak TF-2

    International Nuclear Information System (INIS)

    Budaev, V.P.

    1994-01-01

    It was observed in tokamaks the suppression of edge turbulence causes by setting a radial electric field at the plasma edge. The poloidal plasma rotation governed by this electric field is likely to result in changes in edge convention and poloidal asymmetry, however there is no experimental evidence about that of the experimental database concerning the biasing and conditions of edge plasma electrostatic turbulence excitation is not still complete. Also a relation between macroscopic convection and small-scale electrostatic turbulence have not yet revealed both in biasing and non biasing plasmas. In this paper results from biasing experiments carried on on ohmically heated tokamak TF-2 are presented. Changes in both equilibrium and fluctuated edge plasma parameters also convection and turbulence driven particle flux were demonstrated in probe measurements with biasing of electrode immersed within Last Closed Flux Surface (LCFS). Poloidal edge plasma structure and charge in asymmetry have demonstrated in the biasing experiments. (author). 6 refs, 4 figs

  5. Thermal-hydraulic behaviour of the ITER TF system during a quench development

    International Nuclear Information System (INIS)

    Nicollet, S.; Lacroix, B.; Bessette, D.; Copetti, R.; Duchateau, J.L.; Coatanea-Gouachet, M.; Rodriguez-Mateos, F.

    2011-01-01

    In order to ensure the safety of the ITER TF magnets, a primary quench detection system has been foreseen, based on voltage detection. In addition, a secondary quench detection could rely on signals of thermo-hydraulic nature. As a matter of fact, the development of a quench in a CICC leads to significant variations of pressure and mass flow at the quenched pancake extremities. Analyses of the quench development have thus been performed using the coupled GANDALF and FLOWER codes. This tool allows to simulate the thermo-hydraulic behaviour of one CICC with a model of the external cryogenic circuit. The study has focused on the first seconds of the quench development, supposing that the quench has not been detected earlier by the primary detector. It is shown that signals regarding pressure, mass flow and temperature reach significant high values especially in the connecting feeder associated with the helium inlet. More detailed studies will be needed to select a secondary detector in this region.

  6. Realtime tune measurements in slow-cycling accelerators

    International Nuclear Information System (INIS)

    Herrup, D.

    1997-01-01

    Measurement and control of the tunes, coupling, and chromaticities in storage rings is essential to efficient operation of these accelerators. Yet it has been very difficult to make reliable realtime measurements of these quantities. We have built and commissioned the microprocessor-based Generic Finite State Data Acquisition (GFSDA) system. GFSDA provides turn-by-turn data acquisition and analysis of accelerator signals in a way that can be easily related to accelerator operations. The microprocessor is capable of calculating FFTs and correlations in real time. Both the Fermilab Main Ring and Tevatron use open loop tune, chromaticity, and coupling control, and the GFSDA measurements can easily be used to improve the open loop tables. We can add realtime feedback control with simple extensions of the system. We have used this system to make tune measurements closely spaced in time over an entire Tevatron ramp cycle

  7. Discrete PID Tuning Using Artificial Intelligence Techniques

    Directory of Open Access Journals (Sweden)

    Petr DOLEŽEL

    2009-06-01

    Full Text Available PID controllers are widely used in industry these days due to their useful properties such as simple tuning or robustness. While they are applicable to many control problems, they can perform poorly in some applications. Highly nonlinear system control with constrained manipulated variable can be mentioned as an example. The point of the paper is to string together convenient qualities of conventional PID control and progressive techniques based on Artificial Intelligence. Proposed control method should deal with even highly nonlinear systems. To be more specific, there is described new method of discrete PID controller tuning in this paper. This method tunes discrete PID controller parameters online through the use of genetic algorithm and neural model of controlled system in order to control successfully even highly nonlinear systems. After method description and some discussion, there is performed control simulation and comparison to one chosen conventional control method.

  8. Proportional–Integral–Derivative (PID Controller Tuning using Particle Swarm Optimization Algorithm

    Directory of Open Access Journals (Sweden)

    J. S. Bassi

    2012-08-01

    Full Text Available The proportional-integral-derivative (PID controllers are the most popular controllers used in industry because of their remarkable effectiveness, simplicity of implementation and broad applicability. However, manual tuning of these controllers is time consuming, tedious and generally lead to poor performance. This tuning which is application specific also deteriorates with time as a result of plant parameter changes. This paper presents an artificial intelligence (AI method of particle swarm optimization (PSO algorithm for tuning the optimal proportional-integral derivative (PID controller parameters for industrial processes. This approach has superior features, including easy implementation, stable convergence characteristic and good computational efficiency over the conventional methods. Ziegler- Nichols, tuning method was applied in the PID tuning and results were compared with the PSO-Based PID for optimum control. Simulation results are presented to show that the PSO-Based optimized PID controller is capable of providing an improved closed-loop performance over the Ziegler- Nichols tuned PID controller Parameters. Compared to the heuristic PID tuning method of Ziegler-Nichols, the proposed method was more efficient in improving the step response characteristics such as, reducing the steady-states error; rise time, settling time and maximum overshoot in speed control of DC motor.

  9. New design concepts for ferrite-tuned low-energy-booster cavities

    International Nuclear Information System (INIS)

    Schaffer, G.

    1991-05-01

    The design concepts for ferrite-tuned accelerating cavities discussed in this paper differ from conventional solutions using thick ferrite toroids for frequency tuning. Instead, tuners consisting of an array of ferrite-loaded striplines are investigated. These promise more efficient cooling and higher operational reliability. Layout examples for the SSC-LEB rf system are presented (tuning range 47.5 to 59.8 MHz, repetition frequency 10 Hz). 15 refs., 4 figs., 1 tab

  10. Application research of tune measurement system in Hefei light source

    International Nuclear Information System (INIS)

    Sun Baogen; He Duohui; Xu Hongliang; Lu Ping; Wang Junhua; Gao Yunfeng; Wang Lin; Liu Jinying

    2002-01-01

    The author introduces the measurement and research of some beam parameters using tune measurement system for Hefei Light Source (HLS), which include the betatron tune, beta function, natural chromaticity, corrected chromaticity, and central frequency. Additionally, it also describes the measurement of the influence of DC clearing electrodes on the betatron tune shift and gives some measurement results. The measurement results are compared with the theoretical values and they are in good agreement

  11. Efficient receiver tuning using differential evolution strategies

    Science.gov (United States)

    Wheeler, Caleb H.; Toland, Trevor G.

    2016-08-01

    Differential evolution (DE) is a powerful and computationally inexpensive optimization strategy that can be used to search an entire parameter space or to converge quickly on a solution. The Kilopixel Array Pathfinder Project (KAPPa) is a heterodyne receiver system delivering 5 GHz of instantaneous bandwidth in the tuning range of 645-695 GHz. The fully automated KAPPa receiver test system finds optimal receiver tuning using performance feedback and DE. We present an adaptation of DE for use in rapid receiver characterization. The KAPPa DE algorithm is written in Python 2.7 and is fully integrated with the KAPPa instrument control, data processing, and visualization code. KAPPa develops the technologies needed to realize heterodyne focal plane arrays containing 1000 pixels. Finding optimal receiver tuning by investigating large parameter spaces is one of many challenges facing the characterization phase of KAPPa. This is a difficult task via by-hand techniques. Characterizing or tuning in an automated fashion without need for human intervention is desirable for future large scale arrays. While many optimization strategies exist, DE is ideal for time and performance constraints because it can be set to converge to a solution rapidly with minimal computational overhead. We discuss how DE is utilized in the KAPPa system and discuss its performance and look toward the future of 1000 pixel array receivers and consider how the KAPPa DE system might be applied.

  12. Feedback and feedforward control of frequency tuning to naturalistic stimuli.

    Science.gov (United States)

    Chacron, Maurice J; Maler, Leonard; Bastian, Joseph

    2005-06-08

    Sensory neurons must respond to a wide variety of natural stimuli that can have very different spatiotemporal characteristics. Optimal responsiveness to subsets of these stimuli can be achieved by devoting specialized neural circuitry to different stimulus categories, or, alternatively, this circuitry can be modulated or tuned to optimize responsiveness to current stimulus conditions. This study explores the mechanisms that enable neurons within the initial processing station of the electrosensory system of weakly electric fish to shift their tuning properties based on the spatial extent of the stimulus. These neurons are tuned to low frequencies when the stimulus is restricted to a small region within the receptive field center but are tuned to higher frequencies when the stimulus impinges on large regions of the sensory epithelium. Through a combination of modeling and in vivo electrophysiology, we reveal the respective contributions of the filtering characteristics of extended dendritic structures and feedback circuitry to this shift in tuning. Our results show that low-frequency tuning can result from the cable properties of an extended dendrite that conveys receptor-afferent information to the cell body. The shift from low- to high-frequency tuning, seen in response to spatially extensive stimuli, results from increased wide-band input attributable to activation of larger populations of receptor afferents, as well as the activation of parallel fiber feedback from the cerebellum. This feedback provides a cancellation signal with low-pass characteristics that selectively attenuates low-frequency responsiveness. Thus, with spatially extensive stimuli, these cells preferentially respond to the higher-frequency components of the receptor-afferent input.

  13. Tune measurement at GSI SIS-18. Methods and applications

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Rahul

    2014-05-15

    Two parallel tune measurement systems are installed at GSI SIS-18 based on different principles. The first is called the Tune, Orbit and POSition measurement system TOPOS. Its working principle involves direct digitization of BPM signals at 125 MSa/s, which is used for online bunch-by-bunch position calculation in FPGAs. In the course of this work, position calculation algorithms were developed and studied for real time implementation in the TOPOS FPGAs. The regression fit algorithm is found to be more efficient and robust in comparison to previously used weighted mean algorithm with the baseline restoration procedure. The second system is the Baseband Tune measurement system referred to as BBQ system. The operational principle of this system was conceived at the CERN Beam Instrumentation group and is based on direct diode detection. In the framework of this work, this system was optimized and brought into operation at GSI SIS-18. Front-end data from both systems are used to calculate the tune spectrum every 250-5000 beam revolutions or turns within SIS-18 based on the resolution requirement and the mode of operation. Advanced non-parametric spectrum estimation method like amplitude Capon estimator is compared to the conventional DFT based methods in terms of resolving power and computational requirements for the calculated spectrum. Further the TOPOS and BBQ systems are compared and characterized in terms of sensitivity, reliability and operational usage. The results from both systems are found to be consistent with each other and have their favoured regimes of operation. The effects on tune spectra obtained from both systems were studied with different types of excitations with excitation power levels up to 6 mW/Hz. These systems in association with other beam diagnostic devices at SIS-18 were used to conduct extensive experiments to understand the effect of high intensity beams on the tune spectrum. These careful measurements recorded all the relevant beam

  14. Identification of novel mutations in HFE, HFE2, TfR2, and SLC40A1 genes in Chinese patients affected by hereditary hemochromatosis.

    Science.gov (United States)

    Wang, Yongwei; Du, Yali; Liu, Gang; Guo, Shanshan; Hou, Bo; Jiang, Xianyong; Han, Bing; Chang, Yanzhong; Nie, Guangjun

    2017-04-01

    Hereditary hemochromatosis (HH) is a group of inherited iron-overload disorders associated with pathogenic defects in the genes encoding hemochromatosis (HFE), hemojuvelin (HJV/HFE2), hepcidin (HAMP), transferrin receptor 2 (TfR2), and ferroportin (FPN1/SLC40A1) proteins, and the clinical features are well described. However, there have been only a few detailed reports of HH in Chinese populations. Thus, there is insufficient patient information for population-based analyses in Chinese populations or comparative studies among different ethical groups. In the current work, we describe eight Chinese cases of hereditary hemochromatosis. Gene sequencing results revealed eight mutations (five novel mutations) in HFE, HFE2, TfR2, and SLC40A1 genes in these Chinese HH patients. In addition, we used Polymorphism Phenotyping v2 (Polyphen), Sorting Intolerant From Tolerant (SIFT), and a sequence alignment program to predict the molecular consequences of missense mutations.

  15. Tuning of light-graphene interactions

    DEFF Research Database (Denmark)

    Xiao, Sanshui

    — Graphene opens up for novel optoelectronic applications thanks to its high carrier mobility, ultra-large absorption bandwidth, and extremely fast material response. In particular, the opportunity to control optoelectronic properties through Fermi-level tuning enables electrooptical modulation......, optical-optical switching, and other optoelectronics applications. Except for the statistic gating and chemical doping, the Fermi level of graphene can also be optically tuned. With the aid of external optical pumping, electrons can be excited in the substrate, then move to the graphene layer, leading...... to the electrical doping in graphene. In this talk, I will firstly discuss how the graphene property changes when applying the optical pumping with different incident power. Then I will discuss graphene-silicon microring devices with having a high modulation depth and with a relatively low bias voltage. Finally, I...

  16. Stenting for curved lesions using a novel curved balloon: Preliminary experimental study.

    Science.gov (United States)

    Tomita, Hideshi; Higaki, Takashi; Kobayashi, Toshiki; Fujii, Takanari; Fujimoto, Kazuto

    2015-08-01

    Stenting may be a compelling approach to dilating curved lesions in congenital heart diseases. However, balloon-expandable stents, which are commonly used for congenital heart diseases, are usually deployed in a straight orientation. In this study, we evaluated the effect of stenting with a novel curved balloon considered to provide better conformability to the curved-angled lesion. In vitro experiments: A Palmaz Genesis(®) stent (Johnson & Johnson, Cordis Co, Bridgewater, NJ, USA) mounted on the Goku(®) curve (Tokai Medical Co. Nagoya, Japan) was dilated in vitro to observe directly the behavior of the stent and balloon assembly during expansion. Animal experiment: A short Express(®) Vascular SD (Boston Scientific Co, Marlborough, MA, USA) stent and a long Express(®) Vascular LD stent (Boston Scientific) mounted on the curved balloon were deployed in the curved vessel of a pig to observe the effect of stenting in vivo. In vitro experiments: Although the stent was dilated in a curved fashion, stent and balloon assembly also rotated conjointly during expansion of its curved portion. In the primary stenting of the short stent, the stent was dilated with rotation of the curved portion. The excised stent conformed to the curved vessel. As the long stent could not be negotiated across the mid-portion with the balloon in expansion when it started curving, the mid-portion of the stent failed to expand fully. Furthermore, the balloon, which became entangled with the stent strut, could not be retrieved even after complete deflation. This novel curved balloon catheter might be used for implantation of the short stent in a curved lesion; however, it should not be used for primary stenting of the long stent. Post-dilation to conform the stent to the angled vessel would be safer than primary stenting irrespective of stent length. Copyright © 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

  17. Curve Boxplot: Generalization of Boxplot for Ensembles of Curves.

    Science.gov (United States)

    Mirzargar, Mahsa; Whitaker, Ross T; Kirby, Robert M

    2014-12-01

    In simulation science, computational scientists often study the behavior of their simulations by repeated solutions with variations in parameters and/or boundary values or initial conditions. Through such simulation ensembles, one can try to understand or quantify the variability or uncertainty in a solution as a function of the various inputs or model assumptions. In response to a growing interest in simulation ensembles, the visualization community has developed a suite of methods for allowing users to observe and understand the properties of these ensembles in an efficient and effective manner. An important aspect of visualizing simulations is the analysis of derived features, often represented as points, surfaces, or curves. In this paper, we present a novel, nonparametric method for summarizing ensembles of 2D and 3D curves. We propose an extension of a method from descriptive statistics, data depth, to curves. We also demonstrate a set of rendering and visualization strategies for showing rank statistics of an ensemble of curves, which is a generalization of traditional whisker plots or boxplots to multidimensional curves. Results are presented for applications in neuroimaging, hurricane forecasting and fluid dynamics.

  18. JUMPING THE CURVE

    Directory of Open Access Journals (Sweden)

    René Pellissier

    2012-01-01

    Full Text Available This paper explores the notion ofjump ing the curve,following from Handy 's S-curve onto a new curve with new rules policies and procedures. . It claims that the curve does not generally lie in wait but has to be invented by leadership. The focus of this paper is the identification (mathematically and inferentially ofthat point in time, known as the cusp in catastrophe theory, when it is time to change - pro-actively, pre-actively or reactively. These three scenarios are addressed separately and discussed in terms ofthe relevance ofeach.

  19. Monopoly provision of tune-ins

    Czech Academy of Sciences Publication Activity Database

    Celik, Levent

    -, č. 362 (2008), s. 1-31 ISSN 1211-3298 Institutional research plan: CEZ:MSM0021620846 Keywords : informative advertising * tune-ins * television station Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp362.pdf

  20. Evaluation and enhancement of COBRA-TF efficiency for LWR calculations

    International Nuclear Information System (INIS)

    Cuervo, Diana; Avramova, Maria; Ivanov, Kostadin; Miro, Rafael

    2006-01-01

    Detailed representations of the reactor core generate computational meshes with a high number of cells where the fluid dynamics equations must be solved. An exhaustive analysis of the CPU times needed by the thermal-hydraulic subchannel code COBRA-TF for different stages in the solution process has revealed that the solution of the linear system of pressure equations is the most time consuming process. To improve code efficiency two optimized matrix solvers, Super LU library and Krylov non-stationary iterative methods have been implemented in the code and their performance has been tested using a suite of five test cases. The results of performed comparative analyses have demonstrated that for large cases, the implementation of the Bi-Conjugate Gradient Stabilized (Bi-CGSTAB) Krylov method combined with the incomplete LU factorization with dual truncation strategy (ILUT) pre-conditioner reduced the time used by the code for the solution of the pressure matrix by a factor of 20. Both new solvers converge smoothly regardless of the nature of simulated cases and the mesh structures and improve the stability and accuracy of results compared to the classic Gauss-Seidel iterative method. The obtained results indicate that the direct inversion method is the best option for small cases

  1. JT-60SA TF magnet industrial manufacturing preparation and qualifications

    International Nuclear Information System (INIS)

    Decool, P.; Cloez, H.; Gros, G.; Marechal, J.L.; Torre, A.; Verger, J.M.; Nusbaum, M.; Billotte, G.; Crepel, B.; Bourquard, A.; Davis, S.; Phillips, G.

    2014-01-01

    The general design of the JT-60SA toroidal field system was defined in agreement with all the participants in the project (CEA, ENEA, F4E), the detailed design was issued by the Voluntary Contributors. For the French part including the procurement of 9 of the 18 TF winding packs and their integration in the casings, an industrial contract was signed mid-2011 with Alstom (France). After agreement on manufacturing drawings and QA documentation, the manufacturing process was defined giving the guidelines for the workshop organization and the definition of the required tooling. The critical manufacturing points were identified in the process and, regarding technical requirements, have led to the definition of a set of qualification mockups. They are related to helium inlets, conductor winding and insulation, local conductor bending, electrical joint and terminal areas for the winding pack (WP), as well as winding embedding, case welding, and impregnations for WP integration in the casing. The fabrication processes have been improved and shall be qualified thanks to the manufacture and testing of 12 corresponding mockups. The successful achievement of several key mock-ups gives confidence in the feasibility of the manufacture, and their completion will give the green light to the industrial coils manufacture. (authors)

  2. Dual Smarandache Curves of a Timelike Curve lying on Unit dual Lorentzian Sphere

    OpenAIRE

    Kahraman, Tanju; Hüseyin Ugurlu, Hasan

    2016-01-01

    In this paper, we give Darboux approximation for dual Smarandache curves of time like curve on unit dual Lorentzian sphere. Firstly, we define the four types of dual Smarandache curves of a timelike curve lying on dual Lorentzian sphere.

  3. ATLAS Monte Carlo tunes for MC09

    CERN Document Server

    The ATLAS collaboration

    2010-01-01

    This note describes the ATLAS tunes of underlying event and minimum bias description for the main Monte Carlo generators used in the MC09 production. For the main shower generators, pythia and herwig (with jimmy), the MRST LO* parton distribution functions (PDFs) were used for the first time in ATLAS. Special studies on the performance of these, conceptually new, PDFs for high pt physics processes at LHC energies are presented. In addition, a tune of jimmy for CTEQ6.6 is presented, for use with MC@NLO.

  4. Disorder-tuned charge transport in organic semiconductors

    Science.gov (United States)

    Xu, Feng; Qiu, Dong; Yan, Dadong

    2013-02-01

    We propose that the polaron transport in organic semiconductors is remarkably tuned by the fluctuation of polarization energy. The tuning effect of energetic fluctuation not only causes a continuous transition from non-Arrhenius to Arrhenius temperature activated charge transport with increasing moderate disorder strengths but also results in a band-like conduction in the low disorder regime which benefits from the enhanced mobilities in shallow trap states. As a result, a unified description of polaron transport is obtained for a set of typical organic semiconductors.

  5. Tuned and Balanced Redistributed Charge Scheme for Combined Quantum Mechanical and Molecular Mechanical (QM/MM) Methods and Fragment Methods: Tuning Based on the CM5 Charge Model.

    Science.gov (United States)

    Wang, Bo; Truhlar, Donald G

    2013-02-12

    Tuned and balanced redistributed charge schemes have been developed for modeling the electrostatic fields of bonds that are cut by a quantum mechanical-molecular mechanical boundary in combined quantum mechanical and molecular mechanical (QM/MM) methods. First, the charge is balanced by adjusting the charge on the MM boundary atom to conserve the total charge of the entire QM/MM system. In the balanced smeared redistributed charge (BSRC) scheme, the adjusted MM boundary charge is smeared with a smearing width of 1.0 Å and is distributed in equal portions to the midpoints of the bonds between the MM boundary atom and the MM atoms bonded to it; in the balanced redistributed charge-2 (BRC2) scheme, the adjusted MM boundary charge is distributed as point charges in equal portions to the MM atoms that are bonded to the MM boundary atom. The QM subsystem is capped by a fluorine atom that is tuned to reproduce the sum of partial atomic charges of the uncapped portion of the QM subsystem. The new aspect of the present study is a new way to carry out the tuning process; in particular, the CM5 charge model, rather than the Mulliken population analysis applied in previous studies, is used for tuning the capping atom that terminates the dangling bond of the QM region. The mean unsigned error (MUE) of the QM/MM deprotonation energy for a 15-system test suite of deprotonation reactions is 2.3 kcal/mol for the tuned BSRC scheme (TBSRC) and 2.4 kcal/mol for the tuned BRC2 scheme (TBRC2). As was the case for the original tuning method based on Mulliken charges, the new tuning method performs much better than using conventional hydrogen link atoms, which have an MUE on this test set of about 7 kcal/mol. However, the new scheme eliminates the need to use small basis sets, which can be problematic, and it allows one to be more consistent by tuning the parameters with whatever basis set is appropriate for applications. (Alternatively, since the tuning parameters and partial charges

  6. A microcontroller based tuning mechanism for the magnetron

    International Nuclear Information System (INIS)

    Khan, A.M.; Mahfooz, M.; Hanumaiah, B.; Ganesh; Siddappa, K.

    2006-01-01

    In this paper we report on a control system developed to tune the magnetron frequency to get the maximum beam pulse in the microtron (electron accelerator facility at Mangalore University). The control system so designed consists of a microcontroller, a phase locked loop (PLL) and a digital to analog converter (DAC) to control the magnetron frequency. The voltage value given by the microcontroller through the DAC decides the reference frequency. The PLL gives the error voltage whenever there is difference between the reference and the magnetron frequencies. The microcontroller unit tracks the error voltage and tunes the magnetron with the help of a tuner mechanism connected through a stepper motor. The microcontroller also monitors the beam current level and accordingly adjusts the reference frequency to successfully tune the magnetron. (author)

  7. ECM using Edwards curves

    DEFF Research Database (Denmark)

    Bernstein, Daniel J.; Birkner, Peter; Lange, Tanja

    2013-01-01

    -arithmetic level are as follows: (1) use Edwards curves instead of Montgomery curves; (2) use extended Edwards coordinates; (3) use signed-sliding-window addition-subtraction chains; (4) batch primes to increase the window size; (5) choose curves with small parameters and base points; (6) choose curves with large...

  8. Automatic Monte-Carlo tuning for minimum bias events at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Kama, Sami

    2010-06-22

    The Large Hadron Collider near Geneva Switzerland will ultimately collide protons at a center-of-mass energy of 14 TeV and 40 MHz bunch crossing rate with a luminosity of L=10{sup 34} cm{sup -2}s{sup -1}. At each bunch crossing about 20 soft proton-proton interactions are expected to happen. In order to study new phenomena and improve our current knowledge of the physics these events must be understood. However, the physics of soft interactions are not completely known at such high energies. Different phenomenological models, trying to explain these interactions, are implemented in several Monte-Carlo (MC) programs such as PYTHIA, PHOJET and EPOS. Some parameters in such MC programs can be tuned to improve the agreement with the data. In this thesis a new method for tuning the MC programs, based on Genetic Algorithms and distributed analysis techniques have been presented. This method represents the first and fully automated MC tuning technique that is based on true MC distributions. It is an alternative to parametrization-based automatic tuning. This new method is used in finding new tunes for PYTHIA 6 and 8. These tunes are compared to the tunes found by alternative methods, such as the PROFESSOR framework and manual tuning, and found to be equivalent or better. Charged particle multiplicity, dN{sub ch}/d{eta}, Lorentz-invariant yield, transverse momentum and mean transverse momentum distributions at various center-of-mass energies are generated using default tunes of EPOS, PHOJET and the Genetic Algorithm tunes of PYTHIA 6 and 8. These distributions are compared to measurements from UA5, CDF, CMS and ATLAS in order to investigate the best model available. Their predictions for the ATLAS detector at LHC energies have been investigated both with generator level and full detector simulation studies. Comparison with the data did not favor any model implemented in the generators, but EPOS is found to describe investigated distributions better. New data from ATLAS and

  9. Automatic Monte-Carlo tuning for minimum bias events at the LHC

    International Nuclear Information System (INIS)

    Kama, Sami

    2010-01-01

    The Large Hadron Collider near Geneva Switzerland will ultimately collide protons at a center-of-mass energy of 14 TeV and 40 MHz bunch crossing rate with a luminosity of L=10 34 cm -2 s -1 . At each bunch crossing about 20 soft proton-proton interactions are expected to happen. In order to study new phenomena and improve our current knowledge of the physics these events must be understood. However, the physics of soft interactions are not completely known at such high energies. Different phenomenological models, trying to explain these interactions, are implemented in several Monte-Carlo (MC) programs such as PYTHIA, PHOJET and EPOS. Some parameters in such MC programs can be tuned to improve the agreement with the data. In this thesis a new method for tuning the MC programs, based on Genetic Algorithms and distributed analysis techniques have been presented. This method represents the first and fully automated MC tuning technique that is based on true MC distributions. It is an alternative to parametrization-based automatic tuning. This new method is used in finding new tunes for PYTHIA 6 and 8. These tunes are compared to the tunes found by alternative methods, such as the PROFESSOR framework and manual tuning, and found to be equivalent or better. Charged particle multiplicity, dN ch /dη, Lorentz-invariant yield, transverse momentum and mean transverse momentum distributions at various center-of-mass energies are generated using default tunes of EPOS, PHOJET and the Genetic Algorithm tunes of PYTHIA 6 and 8. These distributions are compared to measurements from UA5, CDF, CMS and ATLAS in order to investigate the best model available. Their predictions for the ATLAS detector at LHC energies have been investigated both with generator level and full detector simulation studies. Comparison with the data did not favor any model implemented in the generators, but EPOS is found to describe investigated distributions better. New data from ATLAS and CMS show higher

  10. The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats

    International Nuclear Information System (INIS)

    Katayama, Seiichi; Ashizawa, Koji; Gohma, Hiroshi; Fukuhara, Tadahiro; Narumi, Kazunori; Tsuzuki, Yasuhiro; Tatemoto, Hideki; Nakada, Tadashi; Nagai, Kenji

    2006-01-01

    The objective of this study was to investigate the effects of estrogen receptor (ER) agonists and an ER antagonist on the expression of Hedgehog genes (Indian hedgehog: Ihh; Desert hedgehog: Dhh) and Hedgehog target genes (Patched 1: Ptc1; glioma-associated oncogene homolog 1: Gli1; chicken ovalbumin upstream promoter transcription factor II: Coup-TfII) in the rat uterus. Immature female rats were administered once with 17α-ethynyl estradiol (EE, an ER agonist), propyl pyrazole triole (PPT, an ERα-selective agonist), diarylpropionitrile (DPN, an ERβ-selective agonist), or ICI 182,780 (an ER antagonist). Expression of mRNA for Ihh, Dhh, and Ptc1 was dose-dependently downregulated by EE in the uterus of immature rats, mediated by ER as confirmed by coadministration of ICI 182,780. The mRNA expression levels of Ptc1, Gli1, and Coup-TfII were simultaneously downregulated during the period in which the mRNA expression levels of Ihh and Dhh were downregulated in the uterus after administration of EE. PPT downregulated the transcription of Ihh, Dhh, Ptc1, Gli1, and Coup-TfII, indicating that expression of these genes was regulated by the ERα-dependent pathway. DPN also downregulated the transcription of Ihh and Dhh, although the effect was weaker than that of PPT, indicating that the regulation of uterine Ihh and Dhh transcription was also affected by the ERβ-dependent pathway. These results suggest that the expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats

  11. The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats.

    Science.gov (United States)

    Katayama, Seiichi; Ashizawa, Koji; Gohma, Hiroshi; Fukuhara, Tadahiro; Narumi, Kazunori; Tsuzuki, Yasuhiro; Tatemoto, Hideki; Nakada, Tadashi; Nagai, Kenji

    2006-12-15

    The objective of this study was to investigate the effects of estrogen receptor (ER) agonists and an ER antagonist on the expression of Hedgehog genes (Indian hedgehog: Ihh; Desert hedgehog: Dhh) and Hedgehog target genes (Patched 1: Ptc1; glioma-associated oncogene homolog 1: Gli1; chicken ovalbumin upstream promoter transcription factor II: Coup-TfII) in the rat uterus. Immature female rats were administered once with 17alpha-ethynyl estradiol (EE, an ER agonist), propyl pyrazole triole (PPT, an ERalpha-selective agonist), diarylpropionitrile (DPN, an ERbeta-selective agonist), or ICI 182,780 (an ER antagonist). Expression of mRNA for Ihh, Dhh, and Ptc1 was dose-dependently downregulated by EE in the uterus of immature rats, mediated by ER as confirmed by coadministration of ICI 182,780. The mRNA expression levels of Ptc1, Gli1, and Coup-TfII were simultaneously downregulated during the period in which the mRNA expression levels of Ihh and Dhh were downregulated in the uterus after administration of EE. PPT downregulated the transcription of Ihh, Dhh, Ptc1, Gli1, and Coup-TfII, indicating that expression of these genes was regulated by the ERalpha-dependent pathway. DPN also downregulated the transcription of Ihh and Dhh, although the effect was weaker than that of PPT, indicating that the regulation of uterine Ihh and Dhh transcription was also affected by the ERbeta-dependent pathway. These results suggest that the expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats.

  12. The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body.

    Directory of Open Access Journals (Sweden)

    Christal A Worthen

    2014-03-01

    Full Text Available Fine tuning of body iron is required to prevent diseases such as iron-overload and anemia. The putative iron-sensor, transferrin receptor 2 (TfR2, is expressed in the liver and mutations in this protein result in the iron-overload disease Type III hereditary hemochromatosis (HH. With the loss of functional TfR2, the liver produces about two-fold less of the peptide hormone hepcidin, which is responsible for negatively regulating iron uptake from the diet. This reduction in hepcidin expression leads to the slow accumulation of iron in the liver, heart, joints, and pancreas and subsequent cirrhosis, heart disease, arthritis, and diabetes. TfR2 can bind iron-loaded transferrin in the bloodstream, and hepatocytes treated with transferrin respond with a two-fold increase in hepcidin expression through stimulation of the BMP-signaling pathway. Loss of functional TfR2 or its binding partner, the original HH protein (HFE, results in a loss of this transferrin-sensitivity. While much is known about the trafficking and regulation of TfR2, the mechanism of its transferrin-sensitivity through the BMP-signaling pathway is still not known.

  13. Iterative Controller Tuning for Process with Fold Bifurcations

    DEFF Research Database (Denmark)

    Huusom, Jakob Kjøbsted; Poulsen, Niels Kjølstad; Jørgensen, Sten Bay

    2007-01-01

    Processes involving fold bifurcation are notoriously difficult to control in the vicinity of the fold where most often optimal productivity is achieved . In cases with limited process insight a model based control synthesis is not possible. This paper uses a data driven approach with an improved...... version of iterative feedback tuning to optimizing a closed loop performance criterion, as a systematic tool for tuning process with fold bifurcations....

  14. Tuning and matching of the BPX ICH system

    International Nuclear Information System (INIS)

    Swain, D.W.

    1991-01-01

    Two methods of tuning and matching the ion cyclotron heating (ICH) antennas for the Burning Plasma Experiment (BPX) to the BPX plasma have been analyzed. Both appear to provide adequate tuning and matching capabilities. However, there are trade-offs between the frequency range that can be covered and the compactness of the high-voltage region of the transmission lines that makes up of the matching network. 4 refs., 5 figs

  15. Tuning controllers using the dual Youla parameterization

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Stoustrup, Jakob

    2000-01-01

    This paper describes the application of the Youla parameterization of all stabilizing controllers and the dual Youla parameterization of all systems stabilized by a given controller in connection with tuning of controllers. In the uncertain case, it is shown that the use of the Youla parameteriza......This paper describes the application of the Youla parameterization of all stabilizing controllers and the dual Youla parameterization of all systems stabilized by a given controller in connection with tuning of controllers. In the uncertain case, it is shown that the use of the Youla...

  16. Java EE 7 performance tuning and optimization

    CERN Document Server

    Oransa, Osama

    2014-01-01

    The book adopts a step-by-step approach, starting from building the basics and adding to it gradually by using different tools and examples. The book sequence is easy to follow and all topics are fully illustrated showing you how to make good use of different performance diagnostic tools. If you are an experienced Java developer, architect, team leader, consultant, support engineer, or anyone else who needs performance tuning in your Java applications, and in particular, Java enterprise applications, this book is for you. No prior experience of performance tuning is required.

  17. A 21st Century Imperative: integrating intercultural competence in Tuning

    Directory of Open Access Journals (Sweden)

    Darla K. Deardorff

    2015-12-01

    Full Text Available Given the increasing demand for interculturally competent graduates and employees, it is incumbent upon the Tuning community to incorporate intercultural competence into Tuning Frameworks. With the growing diversity in the world today, beyond national diversity, intercultural competence cuts across disciplines, subjects, and contexts. This essay highlights the first research-based definition and framework of intercultural competence which can be translated into any subject and context and makes the case for why intercultural competence must be embedded into Tuning Frameworks around the world.

  18. Technological change in energy systems. Learning curves, logistic curves and input-output coefficients

    International Nuclear Information System (INIS)

    Pan, Haoran; Koehler, Jonathan

    2007-01-01

    Learning curves have recently been widely adopted in climate-economy models to incorporate endogenous change of energy technologies, replacing the conventional assumption of an autonomous energy efficiency improvement. However, there has been little consideration of the credibility of the learning curve. The current trend that many important energy and climate change policy analyses rely on the learning curve means that it is of great importance to critically examine the basis for learning curves. Here, we analyse the use of learning curves in energy technology, usually implemented as a simple power function. We find that the learning curve cannot separate the effects of price and technological change, cannot reflect continuous and qualitative change of both conventional and emerging energy technologies, cannot help to determine the time paths of technological investment, and misses the central role of R and D activity in driving technological change. We argue that a logistic curve of improving performance modified to include R and D activity as a driving variable can better describe the cost reductions in energy technologies. Furthermore, we demonstrate that the top-down Leontief technology can incorporate the bottom-up technologies that improve along either the learning curve or the logistic curve, through changing input-output coefficients. An application to UK wind power illustrates that the logistic curve fits the observed data better and implies greater potential for cost reduction than the learning curve does. (author)

  19. The Magnetically-Tuned Transition-Edge Sensor

    Science.gov (United States)

    Sadleir, John E.; Lee, Sang-Jun; Smith, Stephen J.; Busch, Sarah E.; Bandler, Simon R.; Adams, Joseph S.; Eckart, Megan E.; Chevenak, James A.; Kelley, Richard L.; Kilbourne, Caroline A.; hide

    2014-01-01

    We present the first measurements on the proposed magnetically-tuned superconducting transition-edge sensor (MTES) and compare the modified resistive transition with the theoretical prediction. A TES's resistive transition is customarily characterized in terms of the unit less device parameters alpha and beta corresponding to the resistive response to changes in temperature and current respectively. We present a new relationship between measured IV quantities and the parameters alpha and beta and use these relations to confirm we have stably biased a TES with negative beta parameter with magnetic tuning. Motivated by access to this new unexplored parameter space, we investigate the conditions for bias stability of a TES taking into account both self and externally applied magnetic fields.

  20. Basic controller tuning for large offshore wind turbines

    Directory of Open Access Journals (Sweden)

    K. O. Merz

    2016-09-01

    Full Text Available When a wind turbine operates above the rated wind speed, the blade pitch may be governed by a basic single-input–single-output PI controller, with the shaft speed as input. The performance of the wind turbine depends upon the tuning of the gains and filters of this controller. Rules of thumb, based upon pole placement, with a rigid model of the rotor, are inadequate for tuning the controller of large, flexible, offshore wind turbines. It is shown that the appropriate controller tuning is highly dependent upon the characteristics of the aeroelastic model: no single reference controller can be defined for use with all models. As an example, the ubiquitous National Renewable Energy Laboratory (NREL 5 MW wind turbine controller is unstable when paired with a fully flexible aeroelastic model. A methodical search is conducted, in order to find models with a minimum number of degrees of freedom, which can be used to tune the controller for a fully flexible aeroelastic model; this can be accomplished with a model containing 16–20 states. Transient aerodynamic effects, representing rotor-average properties, account for five of these states. A simple method is proposed to reduce the full transient aerodynamic model, and the associated turbulent wind spectra, to the rotor average. Ocean waves are also an important source of loading; it is recommended that the shaft speed signal be filtered such that wave-driven tower side-to-side vibrations do not appear in the PI controller output. An updated tuning for the NREL 5 MW controller is developed using a Pareto front technique. This fixes the instability and gives good performance with fully flexible aeroelastic models.

  1. Technical fine-tuning problem in renormalized perturbation theory

    International Nuclear Information System (INIS)

    Foda, O.E.

    1983-01-01

    The technical - as opposed to physical - fine tuning problem, i.e. the stability of tree-level gauge hierarchies at higher orders in renormalized perturbation theory, in a number of different models is studied. These include softly-broken supersymmetric models, and non-supersymmetric ones with a hierarchy of spontaneously-broken gauge symmetries. The models are renormalized using the BPHZ prescription, with momentum subtractions. Explicit calculations indicate that the tree-level hierarchy is not upset by the radiative corrections, and consequently no further fine-tuning is required to maintain it. Furthermore, this result is shown to run counter to that obtained via Dimensional Renormalization, (the only scheme used in previous literature on the subject). The discrepancy originates in the inherent local ambiguity in the finite parts of subtracted Feynman integrals. Within fully-renormalized perturbation theory the answer to the technical fine-tuning question (in the sense of whether the radiative corrections will ''readily'' respect the tree level gauge hierarchy or not) is contingent on the renormalization scheme used to define the model at the quantum level, rather than on the model itself. In other words, the need for fine-tuning, when it arises, is an artifact of the application of a certain class of renormalization schemes

  2. Technical fine-tuning problem in renormalized perturbation theory

    Energy Technology Data Exchange (ETDEWEB)

    Foda, O.E.

    1983-01-01

    The technical - as opposed to physical - fine tuning problem, i.e. the stability of tree-level gauge hierarchies at higher orders in renormalized perturbation theory, in a number of different models is studied. These include softly-broken supersymmetric models, and non-supersymmetric ones with a hierarchy of spontaneously-broken gauge symmetries. The models are renormalized using the BPHZ prescription, with momentum subtractions. Explicit calculations indicate that the tree-level hierarchy is not upset by the radiative corrections, and consequently no further fine-tuning is required to maintain it. Furthermore, this result is shown to run counter to that obtained via Dimensional Renormalization, (the only scheme used in previous literature on the subject). The discrepancy originates in the inherent local ambiguity in the finite parts of subtracted Feynman integrals. Within fully-renormalized perturbation theory the answer to the technical fine-tuning question (in the sense of whether the radiative corrections will ''readily'' respect the tree level gauge hierarchy or not) is contingent on the renormalization scheme used to define the model at the quantum level, rather than on the model itself. In other words, the need for fine-tuning, when it arises, is an artifact of the application of a certain class of renormalization schemes.

  3. Cyto-molecular Tuning of Quantum Dots

    Science.gov (United States)

    Lee, Bong; Suresh, Sindhuja; Ekpenyong, Andrew

    Quantum dots (QDs) are semiconductor nanoparticles composed of groups II-VI or III-V elements, with physical dimensions smaller than the exciton Bohr radius, and between 1-10 nm. Their applications and promising myriad applications in photovoltaic cells, biomedical imaging, targeted drug delivery, quantum computing, etc, have led to much research on their interactions with other systems. For biological systems, research has focused on biocompatibility and cytotoxicity of QDs in the context of imaging/therapy. However, there is a paucity of work on how biological systems might be used to tune QDs. Here, we hypothesize that the photo-electronic properties of QDs can be tuned by biological macromolecules following controlled changes in cellular activities. Using CdSe/ZnS core-shell QDs, we perform spectroscopic analysis of optically excited colloidal QDs with and without promyelocytic HL60 cells. Preliminary results show shifts in the emission spectra of the colloidal dispersions with and without cells. We will present results for activated HL60-derived cells where specific macromolecules produced by these cells perturb the electric dipole moments of the excited QDs and the associated electric fields, in ways that constitute what we describe as cyto-molecular tuning. Startup funds from the College of Arts and Sciences, Creighton University (to AEE).

  4. Social cognition in autism: Face tuning.

    Science.gov (United States)

    Pavlova, Marina A; Guerreschi, Michele; Tagliavento, Lucia; Gitti, Filippo; Sokolov, Alexander N; Fallgatter, Andreas J; Fazzi, Elisa

    2017-05-26

    Faces convey valuable information for social cognition, effective interpersonal interaction, and non-verbal communication. Face perception is believed to be atypical in autism, but the origin of this deficit is controversial. Dominant featural face encoding is suggested to be responsible for face tuning scarcity. Here we used a recently developed Face-n-Food paradigm for studying face tuning in individuals with autistic spectrum disorders (ASD). The key benefit of these images is that single components do not explicitly trigger face processing. In a spontaneous recognition task, adolescents with autism and typically developing matched controls were presented with a set of Face-n-Food images in different degree resembling a face (slightly bordering on the Giuseppe Arcimboldo style). The set of images was shown in a predetermined order from the least to most resembling a face. Thresholds for recognition of the Face-n-Food images as a face in ASD individuals were substantially higher than in typically developing controls: they did not report seeing a face on the images, which controls easily recognized as a face, and gave overall fewer face responses. This outcome not only lends support to atypical face tuning, but provides novel insights into the origin of face encoding deficits in autism.

  5. AGS tune jump power supply design and test

    International Nuclear Information System (INIS)

    Mi, J.; Glenn, J.W.; Huang, H.; Marneris, I.; Rosas, P.; Sandberg, J.; Tan, Y.; Zhang, W.

    2011-01-01

    A horizontal tune jump system has been installed to overcome the horizontal intrinsic spin resonances, which requires jumping the horizontal tune 0.04 units 82 times, 41 up and 41 down. Two quadruple magnets have been installed in AGS ring to perform this. The pulsed magnet current ranges from about 140A near injection to about 1400A later. The current pulse rise and fall time are around 100uS and flat tops time is around 4mS. These quadruples have separated supplies. This tune jump pulse power supply employees all semiconductor parts as well as the main switches. During dummy load and magnet testing, the test results showed that the power supply could meet the specification. This article will describe some details of power supply simulation, design and testing. Some test waveforms and pictures are presented in this paper.

  6. Distribución volumétrica, simetría del chorro y diámetro de gotas de las boquillas TF-VS2 Spraying distribution, symmetry of fan and droplet size to spray nozzles TF-VS2

    Directory of Open Access Journals (Sweden)

    R.A.A Román

    2010-12-01

    Full Text Available El conocimiento de las características de las diferentes boquillas de pulverización tiene una importancia imprescindible para la adecuada y correcta recomendación de su uso. El objetivo de este trabajo fue determinar el espaciamiento máximo en la barra horizontal de pulverización, la simetría del chorro y el diámetro de gotas en boquillas de pulverización TF-VS2. El trabajo fue realizado en mesa de deposición, en donde fueron utilizadas las presiones de 100, 200 y 300 kPa en las alturas de trabajo de 40 y 50 cm. La simetría del chorro fue determinada en función de dos metodologías (empírica y trigonométrica. También se determinó el tamaño de las gotas, utilizando el método de difracción de rayos laser, en función de dos caldos de pulverización constituidos por agua y por agua con adyuvante en las tres presiones de trabajo ya descritas. Los espaciamientos máximos entre las boquillas en la barra de pulverización no pueden rebasar los 70 y 82 cm, admitiéndose el CV de un 10% para las alturas de 40 y de 50 cm respectivamente. La mayor presión proporcionó el menor diámetro mediano volumétrico (DMV y la peor uniformidad de gotas, además del mayor porcentaje de gotas susceptibles a deriva, así como también aumentó la simetría entre los chorros.The knowledge of spray distribution pattern and analysis of droplets size of spray hydraulic nozzles turbo Floodjet TF-VS2 to adapt the spacing on spray boom are very important for a proper and correct use and recommendations. The aim of this study was to determine the maximum spacing on the horizontal spraying boom held on a patternator to the tips TF-VS2, under pressures of 100, 200 and 300 kPa in heights of work of 40 and 50 cm. Symmetry of spraying fan was determined due empirical and trigonometric methodology. It was also determined the droplets size by means of laser diffraction, with two spray liquids consisting of water and water plus adjuvant under three work pressures

  7. Effect of tune modulation on the transverse stability of storage ring

    International Nuclear Information System (INIS)

    Yang Jiancheng; Xia Jiawen; Wu Junxia; Xia Guoxing; Liu Wei; Yin Xuejun; Liu Yong; Zhou Xuemei; Mao Lijun

    2004-01-01

    The transverse stability is a critical issue in circular accelerator. In this paper, authors analysed the effect of tune modulation on a FODO lattice with sextupole nonlinear through estimating the dynamic aperture including the influence of the distortion along the phase. It turned out that the tune modulation decreases the stability of particle in storage ring, the extent of this decrease depends largely on the amplitude and tune of modulation. (author)

  8. Algorithms for a Precise Determination of the Betatron Tune

    CERN Document Server

    Bartolini, R; Giovannozzi, Massimo; Todesco, Ezio; Scandale, Walter

    1996-01-01

    In circular accelerators the precise knowledge of the betatron tune is of paramount importance both for routine operation and for theoretical investigations. The tune is measured by sampling the transverse position of the beam for N turns and by performing the FFT of the stored data. One can also evaluate it by computing the Average Phase Advance (APA) over N turns. These approaches have an intrinsic error proportional to 1/N. However, there are special cases where either a better precision or a faster measurement is desired. More efficient algorithms can be used, as those suggested by E.Asseo [1] and recently by J. Laskar [2]. They provide tune estimates by far more precise than those of a plain FFT, as discussed in Ref. [3]. Another important isssue is the effect of the finite resolution of the instrumentation used to measure the beam position. This introduces a noise and the frequency response of the beam is modified [4,5} thus reducing the precision by which the tune is determined. In Section 2 we recall ...

  9. Tune and Orbit feedbacks performance: a user perspective

    CERN Document Server

    Ponce, L

    2012-01-01

    The presentation will present the performance and issues of tune and orbit feedbacks seen from the user (operation) perspective. Some statistics on the beam dumps causes will be presented to emphasize the two main limitations of the system : the issue on the tune measurement and the triggering of the QPS system of RQTs circuits. The possible improvements for 2012 will then be discussed together with the foreseen software changes for the orbit reference management.

  10. Tuned Chamber Core Panel Acoustic Test Results

    Science.gov (United States)

    Schiller, Noah H.; Allen, Albert R.

    2016-01-01

    This report documents acoustic testing of tuned chamber core panels, which can be used to supplement the low-frequency performance of conventional acoustic treatment. The tuned chamber core concept incorporates low-frequency noise control directly within the primary structure and is applicable to sandwich constructions with a directional core, including corrugated-, truss-, and fluted-core designs. These types of sandwich structures have long, hollow channels (or chambers) in the core. By adding small holes through one of the facesheets, the hollow chambers can be utilized as an array of low-frequency acoustic resonators. These resonators can then be used to attenuate low-frequency noise (below 400 Hz) inside a vehicle compartment without increasing the weight or size of the structure. The results of this test program demonstrate that the tuned chamber core concept is effective when used in isolation or combined with acoustic foam treatments. Specifically, an array of acoustic resonators integrated within the core of the panels was shown to improve both the low-frequency absorption and transmission loss of the structure in targeted one-third octave bands.

  11. Utilization of genetic algorithm in on-line tuning of fluid power servos

    Energy Technology Data Exchange (ETDEWEB)

    Halme, J.

    1997-12-31

    This study describes a robust and plausible method based on genetic algorithms suitable for tuning a regulator. The main advantages of the method presented is its robustness and easy-to-use feature. In this thesis the method is demonstrated by searching for appropriate control parameters of a state-feedback controller in a fluid power environment. To corroborate the robustness of the tuning method, two earlier studies are also presented in the appendix, where the presented tuning method is used in different kinds of regulator tuning situations. (orig.) 33 refs.

  12. Utilization of genetic algorithm in on-line tuning of fluid power servos

    Energy Technology Data Exchange (ETDEWEB)

    Halme, J

    1998-12-31

    This study describes a robust and plausible method based on genetic algorithms suitable for tuning a regulator. The main advantages of the method presented is its robustness and easy-to-use feature. In this thesis the method is demonstrated by searching for appropriate control parameters of a state-feedback controller in a fluid power environment. To corroborate the robustness of the tuning method, two earlier studies are also presented in the appendix, where the presented tuning method is used in different kinds of regulator tuning situations. (orig.) 33 refs.

  13. Shallow Water Tuned Liquid Dampers

    DEFF Research Database (Denmark)

    Krabbenhøft, Jørgen

    that for realistic roughness parameters the bottom friction has very limited effect on the liquid sloshing behavior and can be neglected. Herby the postulate is verified. Based on the mathematical model three dimensionless parameters are derived showing that the response of the damper depends solely on ratio......The use of sloshing liquid as a passive means of suppressing the rolling motion of ships was proposed already in the late 19th century. Some hundred years later the use of liquid sloshing devices, often termed Tuned Liquid Dampers (TLD), began to find use in the civil engineering community....... The TLDs studied in this thesis essentially consist of a rectangular container partially filled with liquid in the form of plain tap water. The frequency of the liquid sloshing motion, which is adjusted by varying the length of the tank and the depth of the wa- ter, is tuned to the structural frequency...

  14. PSO algorithm enhanced with Lozi Chaotic Map - Tuning experiment

    Energy Technology Data Exchange (ETDEWEB)

    Pluhacek, Michal; Senkerik, Roman; Zelinka, Ivan [Tomas Bata University in Zlín, Faculty of Applied Informatics Department of Informatics and Artificial Intelligence nám. T.G. Masaryka 5555, 760 01 Zlín (Czech Republic)

    2015-03-10

    In this paper it is investigated the effect of tuning of control parameters of the Lozi Chaotic Map employed as a chaotic pseudo-random number generator for the particle swarm optimization algorithm. Three different benchmark functions are selected from the IEEE CEC 2013 competition benchmark set. The Lozi map is extensively tuned and the performance of PSO is evaluated.

  15. PSO algorithm enhanced with Lozi Chaotic Map - Tuning experiment

    International Nuclear Information System (INIS)

    Pluhacek, Michal; Senkerik, Roman; Zelinka, Ivan

    2015-01-01

    In this paper it is investigated the effect of tuning of control parameters of the Lozi Chaotic Map employed as a chaotic pseudo-random number generator for the particle swarm optimization algorithm. Three different benchmark functions are selected from the IEEE CEC 2013 competition benchmark set. The Lozi map is extensively tuned and the performance of PSO is evaluated

  16. Spatially tuned normalization explains attention modulation variance within neurons.

    Science.gov (United States)

    Ni, Amy M; Maunsell, John H R

    2017-09-01

    Spatial attention improves perception of attended parts of a scene, a behavioral enhancement accompanied by modulations of neuronal firing rates. These modulations vary in size across neurons in the same brain area. Models of normalization explain much of this variance in attention modulation with differences in tuned normalization across neurons (Lee J, Maunsell JHR. PLoS One 4: e4651, 2009; Ni AM, Ray S, Maunsell JHR. Neuron 73: 803-813, 2012). However, recent studies suggest that normalization tuning varies with spatial location both across and within neurons (Ruff DA, Alberts JJ, Cohen MR. J Neurophysiol 116: 1375-1386, 2016; Verhoef BE, Maunsell JHR. eLife 5: e17256, 2016). Here we show directly that attention modulation and normalization tuning do in fact covary within individual neurons, in addition to across neurons as previously demonstrated. We recorded the activity of isolated neurons in the middle temporal area of two rhesus monkeys as they performed a change-detection task that controlled the focus of spatial attention. Using the same two drifting Gabor stimuli and the same two receptive field locations for each neuron, we found that switching which stimulus was presented at which location affected both attention modulation and normalization in a correlated way within neurons. We present an equal-maximum-suppression spatially tuned normalization model that explains this covariance both across and within neurons: each stimulus generates equally strong suppression of its own excitatory drive, but its suppression of distant stimuli is typically less. This new model specifies how the tuned normalization associated with each stimulus location varies across space both within and across neurons, changing our understanding of the normalization mechanism and how attention modulations depend on this mechanism. NEW & NOTEWORTHY Tuned normalization studies have demonstrated that the variance in attention modulation size seen across neurons from the same cortical

  17. Closed-loop step response for tuning PID-fractional-order-filter controllers.

    Science.gov (United States)

    Amoura, Karima; Mansouri, Rachid; Bettayeb, Maâmar; Al-Saggaf, Ubaid M

    2016-09-01

    Analytical methods are usually applied for tuning fractional controllers. The present paper proposes an empirical method for tuning a new type of fractional controller known as PID-Fractional-Order-Filter (FOF-PID). Indeed, the setpoint overshoot method, initially introduced by Shamsuzzoha and Skogestad, has been adapted for tuning FOF-PID controller. Based on simulations for a range of first order with time delay processes, correlations have been derived to obtain PID-FOF controller parameters similar to those obtained by the Internal Model Control (IMC) tuning rule. The setpoint overshoot method requires only one closed-loop step response experiment using a proportional controller (P-controller). To highlight the potential of this method, simulation results have been compared with those obtained with the IMC method as well as other pertinent techniques. Various case studies have also been considered. The comparison has revealed that the proposed tuning method performs as good as the IMC. Moreover, it might offer a number of advantages over the IMC tuning rule. For instance, the parameters of the fractional controller are directly obtained from the setpoint closed-loop response data without the need of any model of the plant to be controlled. Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

  18. Computerised curve deconvolution of TL/OSL curves using a popular spreadsheet program.

    Science.gov (United States)

    Afouxenidis, D; Polymeris, G S; Tsirliganis, N C; Kitis, G

    2012-05-01

    This paper exploits the possibility of using commercial software for thermoluminescence and optically stimulated luminescence curve deconvolution analysis. The widely used software package Microsoft Excel, with the Solver utility has been used to perform deconvolution analysis to both experimental and reference glow curves resulted from the GLOw Curve ANalysis INtercomparison project. The simple interface of this programme combined with the powerful Solver utility, allows the analysis of complex stimulated luminescence curves into their components and the evaluation of the associated luminescence parameters.

  19. Computerised curve deconvolution of TL/OSL curves using a popular spreadsheet program

    International Nuclear Information System (INIS)

    Afouxenidis, D.; Polymeris, G. S.; Tsirliganis, N. C.; Kitis, G.

    2012-01-01

    This paper exploits the possibility of using commercial software for thermoluminescence and optically stimulated luminescence curve deconvolution analysis. The widely used software package Microsoft Excel, with the Solver utility has been used to perform deconvolution analysis to both experimental and reference glow curves resulted from the Glow Curve Analysis Intercomparison project. The simple interface of this programme combined with the powerful Solver utility, allows the analysis of complex stimulated luminescence curves into their components and the evaluation of the associated luminescence parameters. (authors)

  20. Light stops and fine-tuning in MSSM

    Energy Technology Data Exchange (ETDEWEB)

    Cici, Ali; Kirca, Zerrin; Uen, Cem Salih [Uludag Univ., Department of Physics, Bursa (Turkey)

    2018-01-15

    We discuss the fine-tuning issue within the MSSM framework. Following the idea that the fine-tuning can measure effects of some missing mechanism, we impose non-universal gaugino masses at the GUT scale, and explore the low scale implications. We realize that the fine-tuning parametrized with Δ{sub EW} can be as low as zero. We consider the stop mass with a special importance and focus on the mass scales as m{sub t} ≤ 700 GeV, which are excluded by the current experiments when the stop decays into a neutralino along with a top quark or a chargino along with a bottom quark. We find that the stop mass can be as low as about 250 GeV with Δ{sub EW} ∝ 50. We find that the solutions in this region can be excluded only up to 60% when stop decays into a neutralino-top quark, and 50% when it decays into a chargino-b quark. Setting 65% CL to be potential exclusion and 95% to be pure exclusion limit such solutions will be tested in near future experiments, which are conducted with higher luminosity. In addition to stop, the region with low fine-tuning and light stops predicts masses for the other supersymmetric particles such as m{sub b} >or similar 700 GeV, m{sub τ} >or similar 1 TeV, m{sub χ{sub 1}{sup {sub ±}}} >or similar 120 GeV. The details for the mass scales and decay rates are also provided by tables of benchmark points. (orig.)

  1. Light stops and fine-tuning in MSSM

    Science.gov (United States)

    Çiçi, Ali; Kırca, Zerrin; Ün, Cem Salih

    2018-01-01

    We discuss the fine-tuning issue within the MSSM framework. Following the idea that the fine-tuning can measure effects of some missing mechanism, we impose non-universal gaugino masses at the GUT scale, and explore the low scale implications. We realize that the fine-tuning parametrized with Δ _{EW} can be as low as zero. We consider the stop mass with a special importance and focus on the mass scales as m_{\\tilde{t}} ≤ 700 GeV, which are excluded by the current experiments when the stop decays into a neutralino along with a top quark or a chargino along with a bottom quark. We find that the stop mass can be as low as about 250 GeV with Δ _{EW} ˜ 50. We find that the solutions in this region can be exluded only up to 60% when stop decays into a neutralino-top quark, and 50% when it decays into a chargino-b quark. Setting 65% CL to be potential exclusion and 95% to be pure exclusion limit such solutions will be tested in near future experiments, which are conducted with higher luminosity. In addition to stop, the region with low fine-tuning and light stops predicts masses for the other supersymmetric particles such as m_{\\tilde{b}} ≳ 700 GeV, m_{\\tilde{τ }} ≳ 1 TeV, m_{\\tilde{χ }1^{± }} ≳ 120 GeV. The details for the mass scales and decay rates are also provided by tables of benchmark points.

  2. Implications for new physics from fine-tuning arguments: II. Little Higgs models

    International Nuclear Information System (INIS)

    Casas, J.A.; Espinosa, J.R.; Hidalgo, I.

    2005-01-01

    We examine the fine-tuning associated to electroweak breaking in Little Higgs scenarios and find it to be always substantial and, generically, much higher than suggested by the rough estimates usually made. This is due to implicit tunings between parameters that can be overlooked at first glance but show up in a more systematic analysis. Focusing on four popular and representative Little Higgs scenarios, we find that the fine-tuning is essentially comparable to that of the Little Hierarchy problem of the Standard Model (which these scenarios attempt to solve) and higher than in supersymmetric models. This does not demonstrate that all Little Higgs models are fine-tuned, but stresses the need of a careful analysis of this issue in model-building before claiming that a particular model is not fine-tuned. In this respect we identify the main sources of potential fine-tuning that should be watched out for, in order to construct a successful Little Higgs model, which seems to be a non-trivial goal. (author)

  3. From Single- to Multi-Objective Auto-Tuning of Programs: Advantages and Implications

    Directory of Open Access Journals (Sweden)

    Juan Durillo

    2014-01-01

    Full Text Available Automatic tuning (auto-tuning of software has emerged in recent years as a promising method that tries to automatically adapt the behaviour of a program to attain different performance objectives on a given computing system. This method is gaining momentum due to the increasing complexity of modern multicore-based hardware architectures. Many solutions to auto-tuning have been explored ranging from simple random search to more sophisticate methods like machine learning or evolutionary search. To this day, it is still unclear whether these approaches are general enough to encompass all the complexities of the problem (e.g. search space, parameters influencing the search space, input data sensitivity, etc., or which approach is best suited for a given problem. Furthermore, the growing interest in auto-tuning a program for several objectives is increasing this confusion even further. The goal of this paper is to formally describe the problem addressed by auto-tuning programs and review existing solutions highlighting the advantages and drawbacks of different techniques for single-objective as well as multi-objective auto-tuning approaches.

  4. A new two-step tuning procedure for a photocathode gun

    International Nuclear Information System (INIS)

    Lal, Shankar; Pant, K.K.; Krishnagopal, S.

    2008-01-01

    An important aspect of the development of multi-cell RF accelerating structures is tuning the resonant frequency f of the operating mode, field balance e b , and waveguide to cavity coupling coefficient β to the desired values. Earlier theoretical analyses have not been able to predict all three parameters simultaneously for a coupled-cavity system. We have developed a generalized circuit analysis to predict f, e b , and β of a coupled structure, based on the RF properties of the individual, uncoupled, cells. This has been used to develop a simplified two-step tuning procedure to tune a BNL/SLAC/UCLA type 1.6 cell S-band photocathode gun by varying RF properties of individual half and full cells, which are easily measurable. This procedure has been validated by tuning two true-to-scale prototypes made of aluminum and ETP copper to the desired values of the RF parameters

  5. Tuned Normalization Explains the Size of Attention Modulations

    OpenAIRE

    Ni, Amy M.; Ray, Supratim; Maunsell, John H.R.

    2012-01-01

    The effect of attention on firing rates varies considerably within a single cortical area. The firing rate of some neurons is greatly modulated by attention while others are hardly affected. The reason for this variability across neurons is unknown. We found that the variability in attention modulation across neurons in area MT of macaques can be well explained by variability in the strength of tuned normalization across neurons. The presence of tuned normalization also explains a striking as...

  6. A Caveat Note on Tuning in the Development of Coupled Climate Models

    Science.gov (United States)

    Dommenget, Dietmar; Rezny, Michael

    2018-01-01

    State-of-the-art coupled general circulation models (CGCMs) have substantial errors in their simulations of climate. In particular, these errors can lead to large uncertainties in the simulated climate response (both globally and regionally) to a doubling of CO2. Currently, tuning of the parameterization schemes in CGCMs is a significant part of the developed. It is not clear whether such tuning actually improves models. The tuning process is (in general) neither documented, nor reproducible. Alternative methods such as flux correcting are not used nor is it clear if such methods would perform better. In this study, ensembles of perturbed physics experiments are performed with the Globally Resolved Energy Balance (GREB) model to test the impact of tuning. The work illustrates that tuning has, in average, limited skill given the complexity of the system, the limited computing resources, and the limited observations to optimize parameters. While tuning may improve model performance (such as reproducing observed past climate), it will not get closer to the "true" physics nor will it significantly improve future climate change projections. Tuning will introduce artificial compensating error interactions between submodels that will hamper further model development. In turn, flux corrections do perform well in most, but not all aspects. A main advantage of flux correction is that it is much cheaper, simpler, more transparent, and it does not introduce artificial error interactions between submodels. These GREB model experiments should be considered as a pilot study to motivate further CGCM studies that address the issues of model tuning.

  7. Successful performances of the EU-AltTF sample, a large size Nb{sub 3}Sn cable-in-conduit conductor with rectangular geometry

    Energy Technology Data Exchange (ETDEWEB)

    Della Corte, A; Corato, V; Di Zenobio, A; Fiamozzi Zignani, C; Muzzi, L; Polli, G M; Reccia, L; Turtu, S [Associazione EURATOM-ENEA sulla Fusione, Via E Fermi 45, 00044 Frascati, Rome (Italy); Bruzzone, P [EPFL-CRPP, Fusion Technology, 5232 Villigen PSI (Switzerland); Salpietro, E [European Fusion Development Agreement, Close Support Unit, Boltzmannstrasse 2, 85748 Garching (Germany); Vostner, A, E-mail: antonio.dellacorte@enea.i [Fusion for Energy, c/ Josep Pla 2, Edificio B3, 08019 Barcelona (Spain)

    2010-04-15

    One of the design features which yet offers interesting margins for performance optimization of cable-in-conduit conductors (CICCs), is their geometry. For relatively small size Nb{sub 3}Sn CICCs, operating at high electromagnetic pressure, such as those for the EDIPO project, it has been experimentally shown that a design based on a rectangular layout with higher aspect ratio leads to the best performance, especially in terms of degradation with electromagnetic loads. To extend this analysis to larger size Nb{sub 3}Sn CICCs, we manufactured and tested, in the SULTAN facility, an ITER toroidal field (TF) cable, inserted into a thick stainless steel tube and then compacted to a high aspect ratio rectangular shape. Besides establishing a new record in Nb{sub 3}Sn CICC performances for ITER TF type cables, the very good test results confirmed that the conductor properties improve not only by lowering the void fraction and raising the cable twist pitch, as already shown during the ITER TFPRO and the EDIPO test campaigns, but also by the proper optimization of the conductor shape with respect to the electromagnetic force distribution. The sample manufacturing steps, along with the main test results, are presented here.

  8. BOREAS TF-10 NSA-Fen Tower Flux and Meteorological Data

    Science.gov (United States)

    McCaughey, J. Harry; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Jelinski, Dennis E.

    2000-01-01

    The BOREAS TF-10 team collected tower flux and meteorological data at two sites, a fen and a young jack pine forest, near Thompson, Manitoba, Canada, as part of BOREAS. A preliminary data set was assembled in August 1993 while field testing the instrument packages, and at both sites data were collected from 15-Aug to 31-Aug. The main experimental period was in 1994, when continuous data were collected from 08-Apr to 23-Sep at the fen site. A very limited experiment was run in the spring/ summer of 1995, when the fen site tower was operated from 08-Apr to 14-Jun in support of a hydrology experiment in an adjoining feeder basin. Upon examination of the 1994 data set, it became clear that the behavior of the heat, water, and carbon dioxide fluxes throughout the whole growing season was an important scientific question, and that the 1994 data record was not sufficiently long to capture the character of the seasonal behavior of the fluxes. Thus, the fen site was operated in 1996 in order to collect data from spring melt to autumn freeze-up. Data were collected from 29-Apr to 05-Nov at the fen site. All variables are presented as 30-minute averages. The data are stored in tabular ASCII files.

  9. PID motion control tuning rules in a damping injection framework

    NARCIS (Netherlands)

    Tadele, T.S.; de Vries, Theodorus J.A.; Stramigioli, Stefano

    2013-01-01

    This paper presents a general design approach for a performance based tuning of a damping injection framework impedance controller by using insights from PID motion control tuning rules. The damping injection framework impedance controller is suitable for human friendly robots as it enhances safety

  10. A PLL based automated magnetron tuning mechanism for electron accelerators

    International Nuclear Information System (INIS)

    Khan, A M; Mahfooz, Mohammed; Sanjeev, Ganesh

    2008-01-01

    In this paper we report on a control system developed to tune the magnetron frequency to get the maximum beam pulse in a Microtron (an electron accelerator facility at Mangalore University). The control system so designed consists of a Microcontroller Unit (MCU), a Phase Locked Loop (PLL) and a Digital to Analog Converter (DAC) to track and tune the magnetron frequency. A PLL is used to track the deviation of the magnetron output frequency, and by monitoring the reflected wave voltage level, the microcontroller unit tunes the magnetron with the help of a tuner mechanism connected through a stepper motor.

  11. A PLL based automated magnetron tuning mechanism for electron accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Khan, A M; Mahfooz, Mohammed [Dept. of Electronics, Mangalore University, Mangalagangotri, Karnataka State, India - 574 199 (India); Sanjeev, Ganesh [Microtron Centre, Mangalore University, Mangalagangotri, Karnataka State, India - 574 199 (India)], E-mail: mahfooz_81@yahoo.com

    2008-09-15

    In this paper we report on a control system developed to tune the magnetron frequency to get the maximum beam pulse in a Microtron (an electron accelerator facility at Mangalore University). The control system so designed consists of a Microcontroller Unit (MCU), a Phase Locked Loop (PLL) and a Digital to Analog Converter (DAC) to track and tune the magnetron frequency. A PLL is used to track the deviation of the magnetron output frequency, and by monitoring the reflected wave voltage level, the microcontroller unit tunes the magnetron with the help of a tuner mechanism connected through a stepper motor.

  12. A Design Algorithm using External Perturbation to Improve Iterative Feedback Tuning Convergence

    DEFF Research Database (Denmark)

    Huusom, Jakob Kjøbsted; Hjalmarsson, Håkan; Poulsen, Niels Kjølstad

    2011-01-01

    Iterative Feedback Tuning constitutes an attractive control loop tuning method for processes in the absence of process insight. It is a purely data driven approach for optimization of the loop performance. The standard formulation ensures an unbiased estimate of the loop performance cost function...... gradient, which is used in a search algorithm for minimizing the performance cost. A slow rate of convergence of the tuning method is often experienced when tuning for disturbance rejection. This is due to a poor signal to noise ratio in the process data. A method is proposed for increasing the data...

  13. Automatic performance tuning of parallel and accelerated seismic imaging kernels

    KAUST Repository

    Haberdar, Hakan

    2014-01-01

    With the increased complexity and diversity of mainstream high performance computing systems, significant effort is required to tune parallel applications in order to achieve the best possible performance for each particular platform. This task becomes more and more challenging and requiring a larger set of skills. Automatic performance tuning is becoming a must for optimizing applications such as Reverse Time Migration (RTM) widely used in seismic imaging for oil and gas exploration. An empirical search based auto-tuning approach is applied to the MPI communication operations of the parallel isotropic and tilted transverse isotropic kernels. The application of auto-tuning using the Abstract Data and Communication Library improved the performance of the MPI communications as well as developer productivity by providing a higher level of abstraction. Keeping productivity in mind, we opted toward pragma based programming for accelerated computation on latest accelerated architectures such as GPUs using the fairly new OpenACC standard. The same auto-tuning approach is also applied to the OpenACC accelerated seismic code for optimizing the compute intensive kernel of the Reverse Time Migration application. The application of such technique resulted in an improved performance of the original code and its ability to adapt to different execution environments.

  14. Enhanced gas absorption in the ionic liquid 1-n-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ([hmim][Tf2N]) confined in silica slit pores: a molecular simulation study.

    Science.gov (United States)

    Shi, Wei; Luebke, David R

    2013-05-07

    Two-dimensional NPxyT and isostress-osmotic (N2PxyTf1) Monte Carlo simulations were used to compute the density and gas absorption properties of the ionic liquid (IL) 1-n-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ([hmim][Tf2N]) confined in silica slit pores (25-45 Å). Self-diffusivity values for both gas and IL were calculated from NVE molecular dynamics simulations using both smooth and atomistic potential models for silica. The simulations showed that the molar volume of [hmim][Tf2N] confined in 25-45-Å silica slit pores is 12-31% larger than that of the bulk IL at 313-573 K and 1 bar. The amounts of CO2, H2, and N2 absorbed in the confined IL are 1.1-3 times larger than those in the bulk IL because of the larger molar volume of the confined IL compared to the bulk IL. The CO2, N2, and H2 molecules are generally absorbed close to the silica wall where the IL density is very low. This arrangement causes the self-diffusivities of these gases in the confined IL to be 2-8 times larger than those in the bulk IL at 298-573 K. The solubilities of water in the confined and bulk ILs are similar, which is likely due to strong water interactions with [hmim][Tf2N] through hydrogen bonding, so that the molar volume of the confined IL plays a less important role in determining the H2O solubility. Water molecules are largely absorbed in the IL-rich region rather than close to the silica wall. The self-diffusivities of water correlate with those of the confined IL. The confined IL exhibits self-diffusivities larger than those of the bulk IL at lower temperatures, but smaller than those of the bulk IL at higher temperatures. The findings from our simulations are consistent with available experimental data for similar confined IL systems.

  15. The Tully-Fisher relation for flat galaxies

    Science.gov (United States)

    Makarov, D. I.; Zaitseva, N. A.; Bizyaev, D. V.

    2018-06-01

    We construct a multiparametric Tully-Fisher (TF) relation for a large sample of edge-on galaxies from the Revised Flat Galaxy Catalog using H I data from the EDD database and parameters from the EGIS catalog. We incorporate a variety of additional parameters including structural parameters of edge-on galaxies in different bandpasses. Besides the rotation curve maximum, only the H I-to-optical luminosity ratio and optical colours play a statistically significant role in the multiparametric TF relation. We are able to decrease the standard deviation of the multiparametric TF relation down to 0.32 mag, which is at the level of best modern samples of galaxies used for studies of the matter motion in the Universe via the TF-relation.

  16. Fast betatron tune controller for circulating beam in a synchrotron

    International Nuclear Information System (INIS)

    Endo, Takuyuki; Hatanaka, Kichiji; Sato, Kenji

    1997-01-01

    When rf quadrupole (RFQ) electric field is applied to the circulating beam in a synchrotron, an equation of motion is reduced to Mathieu's Equation. A new analytical method to obtain an approximate solution has been developed, while a numerical computation was usually applied. Translating the behavior of approximate solution into terms of an RFQ electric field and betatron oscillation, a fast tune control can be achieved by rapid tuning of both amplitude and frequency of rf voltage. This process could be applied to suppress a tune shift caused by a space charge effect and to control a slow beam extraction with a low ripple. We have started another analytical computation using Hamiltonian with perturbation of RFQ and the results of this computation also suggest that it is applicable to slow beam extraction. The fast tune controller has been constructed and the beam test will be performed at HIMAC synchrotron in cooperation of RCNP and NIRS. (author)

  17. Tuning of active vibration controllers for ACTEX by genetic algorithm

    Science.gov (United States)

    Kwak, Moon K.; Denoyer, Keith K.

    1999-06-01

    This paper is concerned with the optimal tuning of digitally programmable analog controllers on the ACTEX-1 smart structures flight experiment. The programmable controllers for each channel include a third order Strain Rate Feedback (SRF) controller, a fifth order SRF controller, a second order Positive Position Feedback (PPF) controller, and a fourth order PPF controller. Optimal manual tuning of several control parameters can be a difficult task even though the closed-loop control characteristics of each controller are well known. Hence, the automatic tuning of individual control parameters using Genetic Algorithms is proposed in this paper. The optimal control parameters of each control law are obtained by imposing a constraint on the closed-loop frequency response functions using the ACTEX mathematical model. The tuned control parameters are then uploaded to the ACTEX electronic control electronics and experiments on the active vibration control are carried out in space. The experimental results on ACTEX will be presented.

  18. Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation.

    Science.gov (United States)

    Li, Congxin; Cesbron, François; Oehler, Michael; Brunner, Michael; Höfer, Thomas

    2018-04-25

    Gene regulation is a complex non-equilibrium process. Here, we show that quantitating the temporal regulation of key gene states (transcriptionally inactive, active, and refractory) provides a parsimonious framework for analyzing gene regulation. Our theory makes two non-intuitive predictions. First, for transcription factors (TFs) that regulate transcription burst frequency, as opposed to amplitude or duration, weak TF binding is sufficient to elicit strong transcriptional responses. Second, refractoriness of a gene after a transcription burst enables rapid responses to stimuli. We validate both predictions experimentally by exploiting the natural, optogenetic-like responsiveness of the Neurospora GATA-type TF White Collar Complex (WCC) to blue light. Further, we demonstrate that differential regulation of WCC target genes is caused by different gene activation rates, not different TF occupancy, and that these rates are tuned by both the core promoter and the distance between TF-binding site and core promoter. In total, our work demonstrates the relevance of a kinetic, non-equilibrium framework for understanding transcriptional regulation. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Hardware and software systems for the determination of charged particle parameters in low pressure plasmas using impedance-tuned Langmuir probes

    Science.gov (United States)

    Ye, Yuancai; Marcus, R. Kenneth

    1997-12-01

    A computer-controlled, impedance-tuned Langmuir probe data acquisition system and processing software package have been designed for the diagnostic study of low pressure plasmas. The combination of impedance-tuning and a wide range of applied potentials (± 100 V) provides a versatile system, applicable to a variety of analytical plasmas without significant modification. The automated probe system can be used to produce complete and undistorted current-voltage (i-V) curves with extremely low noise over the wide potential range. Based on these hardware and software systems, it is possible to determine all of the important charged particle parameters in a plasma; electron number density ( ne), ion number density ( ni), electron temperature ( Te), electron energy distribution function (EEDF), and average electron energy (). The complete data acquisition system and evaluation software are described in detail. A LabView (National Instruments Corporation, Austin, TX) application program has been developed for the Apple Macintosh line of microcomputers to control all of the operational aspects of the Langmuir probe experiments. The description here is mainly focused on the design aspects of the acquisition system with the targets of extremely low noise and reduction of the influence of measurement noise in the calculation procedures. This is particularly important in the case of electron energy distribution functions where multiple derivatives are calculated from the obtained i-V curves. A separate C-language data processing program has been developed and is included here to allow the reader to evaluate data obtained with the described hardware, or any i-V data imported in tab separated variable format. Both of the software systems are included on a Macintosh formatted disk for their use in other laboratories desiring these capabilities.

  20. Approximation by planar elastic curves

    DEFF Research Database (Denmark)

    Brander, David; Gravesen, Jens; Nørbjerg, Toke Bjerge

    2016-01-01

    We give an algorithm for approximating a given plane curve segment by a planar elastic curve. The method depends on an analytic representation of the space of elastic curve segments, together with a geometric method for obtaining a good initial guess for the approximating curve. A gradient......-driven optimization is then used to find the approximating elastic curve....

  1. Graphene Dirac point tuned by ferroelectric polarization field

    Science.gov (United States)

    Wang, Xudong; Chen, Yan; Wu, Guangjian; Wang, Jianlu; Tian, Bobo; Sun, Shuo; Shen, Hong; Lin, Tie; Hu, Weida; Kang, Tingting; Tang, Minghua; Xiao, Yongguang; Sun, Jinglan; Meng, Xiangjian; Chu, Junhao

    2018-04-01

    Graphene has received numerous attention for future nanoelectronics and optoelectronics. The Dirac point is a key parameter of graphene that provides information about its carrier properties. There are lots of methods to tune the Dirac point of graphene, such as chemical doping, impurities, defects, and disorder. In this study, we report a different approach to tune the Dirac point of graphene using a ferroelectric polarization field. The Dirac point can be adjusted to near the ferroelectric coercive voltage regardless its original position. We have ensured this phenomenon by temperature-dependent experiments, and analyzed its mechanism with the theory of impurity correlation in graphene. Additionally, with the modulation of ferroelectric polymer, the current on/off ratio and mobility of graphene transistor both have been improved. This work provides an effective method to tune the Dirac point of graphene, which can be readily used to configure functional devices such as p-n junctions and inverters.

  2. Tune-control improvements on the rapid-cycling synchrotron

    International Nuclear Information System (INIS)

    Potts, C.; Faber, M.; Gunderson, G.; Knott, M.; Voss, D.

    1981-01-01

    The as-built lattice of the Rapid-Cycling Synchrotron (RCS) had two sets of correction sextupoles and two sets of quadrupoles energized by dc power supplies to control the tune and the tune tilt. With this method of powering these magnets, adjustment of tune conditions during the accelerating cycle as needed was not possible. A set of dynamically programmable power supplies has been built and operated to provide the required chromaticity adjustment. The short accelerating time (16.7 ms) of the RCS and the inductance of the magnets dictated large transistor amplifier power supplies. The required time resolution and waveform flexibility indicated the desirability of computer control. Both the amplifiers and controls are described, along with resulting improvements in the beam performance. A set of octupole magnets and programmable power supplies with similar dynamic qualities have been constructed and installed to control the anticipated high-intensity transverse instability. This system will be operational in the spring of 1981

  3. Architecture of Automated Database Tuning Using SGA Parameters

    Directory of Open Access Journals (Sweden)

    Hitesh KUMAR SHARMA

    2012-05-01

    Full Text Available Business Data always growth from kilo byte, mega byte, giga byte, tera byte, peta byte, and so far. There is no way to avoid this increasing rate of data till business still running. Because of this issue, database tuning be critical part of a information system. Tuning a database in a cost-effective manner is a growing challenge. The total cost of ownership (TCO of information technology needs to be significantly reduced by minimizing people costs. In fact, mistakes in operations and administration of information systems are the single most reasons for system outage and unacceptable performance [3]. One way of addressing the challenge of total cost of ownership is by making information systems more self-managing. A particularly difficult piece of the ambitious vision of making database systems self-managing is the automation of database performance tuning. In this paper, we will explain the progress made thus far on this important problem. Specifically, we will propose the architecture and Algorithm for this problem.

  4. The Fine-Tuning of the Universe for Intelligent Life

    Science.gov (United States)

    Barnes, L. A.

    2012-06-01

    The fine-tuning of the universe for intelligent life has received a great deal of attention in recent years, both in the philosophical and scientific literature. The claim is that in the space of possible physical laws, parameters and initial conditions, the set that permits the evolution of intelligent life is very small. I present here a review of the scientific literature, outlining cases of fine-tuning in the classic works of Carter, Carr and Rees, and Barrow and Tipler, as well as more recent work. To sharpen the discussion, the role of the antagonist will be played by Victor Stenger's recent book The Fallacy of Fine-Tuning: Why the Universe is Not Designed for Us. Stenger claims that all known fine-tuning cases can be explained without the need for a multiverse. Many of Stenger's claims will be found to be highly problematic. We will touch on such issues as the logical necessity of the laws of nature; objectivity, invariance and symmetry; theoretical physics and possible universes; entropy in cosmology; cosmic inflation and initial conditions; galaxy formation; the cosmological constant; stars and their formation; the properties of elementary particles and their effect on chemistry and the macroscopic world; the origin of mass; grand unified theories; and the dimensionality of space and time. I also provide an assessment of the multiverse, noting the significant challenges that it must face. I do not attempt to defend any conclusion based on the fine-tuning of the universe for intelligent life. This paper can be viewed as a critique of Stenger's book, or read independently.

  5. Bragg Curve Spectroscopy

    International Nuclear Information System (INIS)

    Gruhn, C.R.

    1981-05-01

    An alternative utilization is presented for the gaseous ionization chamber in the detection of energetic heavy ions, which is called Bragg Curve Spectroscopy (BCS). Conceptually, BCS involves using the maximum data available from the Bragg curve of the stopping heavy ion (HI) for purposes of identifying the particle and measuring its energy. A detector has been designed that measures the Bragg curve with high precision. From the Bragg curve the range from the length of the track, the total energy from the integral of the specific ionization over the track, the dE/dx from the specific ionization at the beginning of the track, and the Bragg peak from the maximum of the specific ionization of the HI are determined. This last signal measures the atomic number, Z, of the HI unambiguously

  6. Frequency doubled dye laser with a servo-tuned crystal

    Energy Technology Data Exchange (ETDEWEB)

    Kuhl, J; Spitschan, H

    1975-01-01

    Spectral tuning of the uv output of a frequency doubled dye laser was successfully controlled by a servo motor system which tilts the nonlinear crystal appropriate for phase-matched second harmonic generation while the dye laser emission wavelength is tuned. The spatial direction of the generated uv beam was used as the regulating signal. The feasibility of this technique for spectroscopic applications was successfully tested.

  7. Au nanoparticles decorated SiO2 nanowires by dewetting on curved surfaces: facile synthesis and nanoparticles–nanowires sizes correlation

    International Nuclear Information System (INIS)

    Ruffino, F.; Grimaldi, M. G.

    2013-01-01

    We report a solid-state synthesis for SiO 2 nanowires (NWs) (up to 20 microns in length and from about 40 to about 150 nm in diameter) coated by Au nanoparticles (NPs) (from about 20 to about 80 nm in diameter). This protocol is based on three steps: (1) large area production of very long SiO 2 NWs on a Si surface exploiting a simple Au/Si solid-state reaction at high temperature; (2) coating of the SiO 2 NWs by a Au film of desired thickness using sputtering depositions; and (3) a thermal process to induce a dewetting process of the Au-film coating the SiO 2 NWs to obtain Au NPs on the curved surface of the NWs. The morphology evolution of the SiO 2 NWs was followed, in each step, by scanning electron microscopy analyses. They allowed to correlate the evolution of the NPs size with the NWs sizes for different thicknesses of the starting Au-film coating the NWs and different annealing temperatures of the dewetting process. Some theoretical concepts, related to the dewetting process of a film on a curved surface were used to describe the experimental data. The main advantages of the proposed protocols include: (i) simplicity and low-cost (it is based only on sputtering depositions and thermal processes), and (ii) versatility based on the possibility of tuning Au-film thickness and annealing temperature to tune the NPs–NWs sizes ratio. These advantages can make this technique suitable for the mass production of Au NPs-coated SiO 2 NWs toward applications in electronic devices, biosensors, and nanoscale optical devices

  8. Frustration tuning and perfect phase synchronization in the Kuramoto-Sakaguchi model.

    Science.gov (United States)

    Brede, Markus; Kalloniatis, Alexander C

    2016-06-01

    We present an analysis of conditions under which the dynamics of a frustrated Kuramoto-or Kuramoto-Sakaguchi-model on sparse networks can be tuned to enhance synchronization. Using numerical optimization techniques, linear stability, and dimensional reduction analysis, a simple tuning scheme for setting node-specific frustration parameters as functions of native frequencies and degrees is developed. Finite-size scaling analysis reveals that even partial application of the tuning rule can significantly reduce the critical coupling for the onset of synchronization. In the second part of the paper, a codynamics is proposed, which allows a dynamic tuning of frustration parameters simultaneously with the ordinary Kuramoto dynamics. We find that such codynamics enhance synchronization when operating on slow time scales, and impede synchronization when operating on fast time scales relative to the Kuramoto dynamics.

  9. Improve performance of scanning probe microscopy by balancing tuning fork prongs

    International Nuclear Information System (INIS)

    Ng, Boon Ping; Zhang Ying; Wei Kok, Shaw; Chai Soh, Yeng

    2009-01-01

    This paper presents an approach for improving the Q-factor of tuning fork probe used in scanning probe microscopes. The improvement is achieved by balancing the fork prongs with extra mass attachment. An analytical model is proposed to characterize the Q-factor of a tuning fork probe with respect to the attachment of extra mass on the tuning fork prongs, and based on the model, the Q-factors of the unbalanced and balanced tuning fork probes are derived and compared. Experimental results showed that the model fits well the experimental data and the approach can improve the Q-factor by more than a factor of three. The effectiveness of the approach is further demonstrated by applying the balanced probe on an atomic force microscope to obtain improved topographic images.

  10. Auto-tuning Non-blocking Collective Communication Operations

    KAUST Repository

    Barigou, Youcef; Venkatesan, Vishwanath; Gabriel, Edgar

    2015-01-01

    Collective operations are widely used in large scale scientific applications, and critical to the scalability of these applications for large process counts. It has also been demonstrated that collective operations have to be carefully tuned for a given platform and application scenario to maximize their performance. Non-blocking collective operations extend the concept of collective operations by offering the additional benefit of being able to overlap communication and computation. This paper presents the automatic run-time tuning of non-blocking collective communication operations, which allows the communication library to choose the best performing implementation for a non-blocking collective operation on a case by case basis. The paper demonstrates that libraries using a single algorithm or implementation for a non-blocking collective operation will inevitably lead to suboptimal performance in many scenarios, and thus validate the necessity for run-time tuning of these operations. The benefits of the approach are further demonstrated for an application kernel using a multi-dimensional Fast Fourier Transform. The results obtained for the application scenario indicate a performance improvement of up to 40% compared to the current state of the art.

  11. Auto-tuning Non-blocking Collective Communication Operations

    KAUST Repository

    Barigou, Youcef

    2015-05-01

    Collective operations are widely used in large scale scientific applications, and critical to the scalability of these applications for large process counts. It has also been demonstrated that collective operations have to be carefully tuned for a given platform and application scenario to maximize their performance. Non-blocking collective operations extend the concept of collective operations by offering the additional benefit of being able to overlap communication and computation. This paper presents the automatic run-time tuning of non-blocking collective communication operations, which allows the communication library to choose the best performing implementation for a non-blocking collective operation on a case by case basis. The paper demonstrates that libraries using a single algorithm or implementation for a non-blocking collective operation will inevitably lead to suboptimal performance in many scenarios, and thus validate the necessity for run-time tuning of these operations. The benefits of the approach are further demonstrated for an application kernel using a multi-dimensional Fast Fourier Transform. The results obtained for the application scenario indicate a performance improvement of up to 40% compared to the current state of the art.

  12. Control of a Quadrotor Using a Smart Self-Tuning Fuzzy PID Controller

    Directory of Open Access Journals (Sweden)

    Deepak Gautam

    2013-11-01

    Full Text Available This paper deals with the modelling, simulation-based controller design and path planning of a four rotor helicopter known as a quadrotor. All the drags, aerodynamic, coriolis and gyroscopic effect are neglected. A Newton-Euler formulation is used to derive the mathematical model. A smart self-tuning fuzzy PID controller based on an EKF algorithm is proposed for the attitude and position control of the quadrotor. The PID gains are tuned using a self-tuning fuzzy algorithm. The self-tuning of fuzzy parameters is achieved based on an EKF algorithm. A smart selection technique and exclusive tuning of active fuzzy parameters is proposed to reduce the computational time. Dijkstra's algorithm is used for path planning in a closed and known environment filled with obstacles and/or boundaries. The Dijkstra algorithm helps avoid obstacle and find the shortest route from a given initial position to the final position.

  13. The fine-tuning cost of the likelihood in SUSY models

    International Nuclear Information System (INIS)

    Ghilencea, D.M.; Ross, G.G.

    2013-01-01

    In SUSY models, the fine-tuning of the electroweak (EW) scale with respect to their parameters γ i ={m 0 ,m 1/2 ,μ 0 ,A 0 ,B 0 ,…} and the maximal likelihood L to fit the experimental data are usually regarded as two different problems. We show that, if one regards the EW minimum conditions as constraints that fix the EW scale, this commonly held view is not correct and that the likelihood contains all the information about fine-tuning. In this case we show that the corrected likelihood is equal to the ratio L/Δ of the usual likelihood L and the traditional fine-tuning measure Δ of the EW scale. A similar result is obtained for the integrated likelihood over the set {γ i }, that can be written as a surface integral of the ratio L/Δ, with the surface in γ i space determined by the EW minimum constraints. As a result, a large likelihood actually demands a large ratio L/Δ or equivalently, a small χ new 2 =χ old 2 +2lnΔ. This shows the fine-tuning cost to the likelihood (χ new 2 ) of the EW scale stability enforced by SUSY, that is ignored in data fits. A good χ new 2 /d.o.f.≈1 thus demands SUSY models have a fine-tuning amount Δ≪exp(d.o.f./2), which provides a model-independent criterion for acceptable fine-tuning. If this criterion is not met, one can thus rule out SUSY models without a further χ 2 /d.o.f. analysis. Numerical methods to fit the data can easily be adapted to account for this effect.

  14. Importance of beam-beam tune spread to collective beam-beam instability in hadron colliders

    International Nuclear Information System (INIS)

    Jin Lihui; Shi Jicong

    2004-01-01

    In hadron colliders, electron-beam compensation of beam-beam tune spread has been explored for a reduction of beam-beam effects. In this paper, effects of the tune-spread compensation on beam-beam instabilities were studied with a self-consistent beam-beam simulation in model lattices of Tevatron and Large Hodron Collider. It was found that the reduction of the tune spread with the electron-beam compensation could induce a coherent beam-beam instability. The merit of the compensation with different degrees of tune-spread reduction was evaluated based on beam-size growth. When two beams have a same betatron tune, the compensation could do more harm than good to the beams when only beam-beam effects are considered. If a tune split between two beams is large enough, the compensation with a small reduction of the tune spread could benefit beams as Landau damping suppresses the coherent beam-beam instability. The result indicates that nonlinear (nonintegrable) beam-beam effects could dominate beam dynamics and a reduction of beam-beam tune spread by introducing additional beam-beam interactions and reducing Landau damping may not improve the stability of beams

  15. Learning Curve? Which One?

    Directory of Open Access Journals (Sweden)

    Paulo Prochno

    2004-07-01

    Full Text Available Learning curves have been studied for a long time. These studies provided strong support to the hypothesis that, as organizations produce more of a product, unit costs of production decrease at a decreasing rate (see Argote, 1999 for a comprehensive review of learning curve studies. But the organizational mechanisms that lead to these results are still underexplored. We know some drivers of learning curves (ADLER; CLARK, 1991; LAPRE et al., 2000, but we still lack a more detailed view of the organizational processes behind those curves. Through an ethnographic study, I bring a comprehensive account of the first year of operations of a new automotive plant, describing what was taking place on in the assembly area during the most relevant shifts of the learning curve. The emphasis is then on how learning occurs in that setting. My analysis suggests that the overall learning curve is in fact the result of an integration process that puts together several individual ongoing learning curves in different areas throughout the organization. In the end, I propose a model to understand the evolution of these learning processes and their supporting organizational mechanisms.

  16. Neural Networks for Self-tuning Control Systems

    Directory of Open Access Journals (Sweden)

    A. Noriega Ponce

    2004-01-01

    Full Text Available In this paper, we presented a self-tuning control algorithm based on a three layers perceptron type neural network. The proposed algorithm is advantageous in the sense that practically a previous training of the net is not required and some changes in the set-point are generally enough to adjust the learning coefficient. Optionally, it is possible to introduce a self-tuning mechanism of the learning coefficient although by the moment it is not possible to give final conclusions about this possibility. The proposed algorithm has the special feature that the regulation error instead of the net output error is retropropagated for the weighting coefficients modifications. 

  17. Adaptive control for a PWR using a self-tuning reference model concept

    International Nuclear Information System (INIS)

    Miley, G.H.; Park, G.T.; Kim, B.S.

    1992-01-01

    Possible applications of an adaptive control method to a pressurized-water reactor nuclear power plant are investigated. The self-tuning technique with a reference model concept is employed. This control algorithm is developed by combining the self-tuning controller with the model reference adaptive control. This approach overcomes the difficulties in choosing the appropriate weighting polynomials in the cost function of the self-tuning control

  18. Contractibility of curves

    Directory of Open Access Journals (Sweden)

    Janusz Charatonik

    1991-11-01

    Full Text Available Results concerning contractibility of curves (equivalently: of dendroids are collected and discussed in the paper. Interrelations tetween various conditions which are either sufficient or necessary for a curve to be contractible are studied.

  19. Tuning the LEDA RFQ 6.7 MeV accelerator

    International Nuclear Information System (INIS)

    Young, L.M.; Rybarcyk, L.

    1998-01-01

    This paper presents the results of tuning the 8 meter long Radio Frequency Quadrupole (RFQ) built for the Low Energy Demonstration Accelerator (LEDA). This 350-MHz RFQ is split into four 2-meter-long-RFQs. Then they are joined with resonant coupling to form an 8-meter-long RFQ. This improves both the longitudinal stability and the transverse stability of this long RFQ. The frequencies of the modes near the RFQ mode are measured. The authors show the effect on the RF fields of an error in the temperature of each one of the 2-meter-long-RFQs. Slug tuners distributed along the outer walls tune the RFQ. The program RFQTUNE is used to determine the length of the tuners. The tuners are machined to length when the final tuning is complete

  20. Roc curves for continuous data

    CERN Document Server

    Krzanowski, Wojtek J

    2009-01-01

    Since ROC curves have become ubiquitous in many application areas, the various advances have been scattered across disparate articles and texts. ROC Curves for Continuous Data is the first book solely devoted to the subject, bringing together all the relevant material to provide a clear understanding of how to analyze ROC curves.The fundamental theory of ROC curvesThe book first discusses the relationship between the ROC curve and numerous performance measures and then extends the theory into practice by describing how ROC curves are estimated. Further building on the theory, the authors prese

  1. ZIF-8 gate tuning via terminal group modification: a computational study

    KAUST Repository

    Zheng, Bin; Wang, Lian Li; Du, Lifei; Huang, Kuo-Wei; Du, Huiling

    2016-01-01

    Tuning the pore structure of zeolitic imidazolate frameworks (ZIFs) enables unique control of their material properties. In this work, we used computational methods to examine the gate structure of ZIF-8 tuned by substitution terminal groups

  2. Thermal-hydraulic analysis of LTS cables for the DEMO TF coil using simplified models

    Directory of Open Access Journals (Sweden)

    Lewandowska Monika

    2017-03-01

    Full Text Available The conceptual design activities for the DEMOnstration reactor (DEMO – the prototype fusion power plant – are conducted in Europe by the EUROfusion Consortium. In 2015, three design concepts of the DEMO toroidal field (TF coil were proposed by Swiss Plasma Center (EPFL-SPC, PSI Villigen, Italian National Agency for New Technologies (ENEA Frascati, and Atomic Energy and Alternative Energies Commission (CEA Cadarache. The proposed conductor designs were subjected to complete mechanical, electromagnetic, and thermal-hydraulic analyses. The present study is focused on the thermal-hydraulic analysis of the candidate conductor designs using simplified models. It includes (a hydraulic analysis, (b heat removal analysis, and (c assessment of the maximum temperature and the maximum pressure in each conductor during quench. The performed analysis, aimed at verification whether the proposed design concepts fulfil the established acceptance criteria, provides the information for further improvements of the coil and conductors design.

  3. A tuning approach for offset-free MPC with conditional reference adaptation

    DEFF Research Database (Denmark)

    Waschl, Harald; Jørgensen, John Bagterp; Huusom, Jakob Kjøbsted

    2014-01-01

    Model predictive control has become a widely accepted strategy in industrial applications in the recent years. Often mentioned reasons for the success are the optimization based on a system model, consideration of constraints and an intuitive tuning process. However, as soon as unknown disturbances...... properties these controllers can be tuned separate and by known guidelines. To address conditions with active input constraints, additionally a conditional reference adaptation scheme is introduced. The tuning strategy is evaluated on a simulated linear Wood-Berry binary distillation column example....

  4. PID-Controller Tuning Optimization with Genetic Algorithms in Servo Systems

    Directory of Open Access Journals (Sweden)

    Arturo Y. Jaen-Cuellar

    2013-09-01

    Full Text Available Performance improvement is the main goal of the study of PID control and much research has been conducted for this purpose. The PID filter is implemented in almost all industrial processes because of its well-known beneficial features. In general, the whole system's performance strongly depends on the controller's efficiency and hence the tuning process plays a key role in the system's behaviour. In this work, the servo systems will be analysed, specifically the positioning control systems. Among the existent tuning methods, the Gain-Phase Margin method based on Frequency Response analysis is the most adequate for controller tuning in positioning control systems. Nevertheless, this method can be improved by integrating an optimization technique. The novelty of this work is the development of a new methodology for PID control tuning by coupling the Gain-Phase Margin method with the Genetic Algorithms in which the micro-population concept and adaptive mutation probability are applied. Simulations using a positioning system model in MATLAB and experimental tests in two CNC machines and an industrial robot are carried out in order to show the effectiveness of the proposal. The obtained results are compared with both the classical Gain-Phase Margin tuning and with a recent PID controller optimization using Genetic Algorithms based on real codification. The three methodologies are implemented using software.

  5. Quantum-Tuned Two-Junction Solar Cells

    KAUST Repository

    Wang, Xihua

    2011-01-01

    We report quantum-size-effect tuned tandem solar cells. Our two-junction photovoltaic devices employ light-absorbing material of a single composition and use two rationally-selected nanoparticle sizes to harvest the sun’s broad spectrum.

  6. Atlas of stress-strain curves

    CERN Document Server

    2002-01-01

    The Atlas of Stress-Strain Curves, Second Edition is substantially bigger in page dimensions, number of pages, and total number of curves than the previous edition. It contains over 1,400 curves, almost three times as many as in the 1987 edition. The curves are normalized in appearance to aid making comparisons among materials. All diagrams include metric (SI) units, and many also include U.S. customary units. All curves are captioned in a consistent format with valuable information including (as available) standard designation, the primary source of the curve, mechanical properties (including hardening exponent and strength coefficient), condition of sample, strain rate, test temperature, and alloy composition. Curve types include monotonic and cyclic stress-strain, isochronous stress-strain, and tangent modulus. Curves are logically arranged and indexed for fast retrieval of information. The book also includes an introduction that provides background information on methods of stress-strain determination, on...

  7. A novel technique for tuning of co-axial cavity of multi-beam klystron

    Energy Technology Data Exchange (ETDEWEB)

    Saha, Sukalyan, E-mail: sstechno18@gmail.com; Bandyopadhyay, Ayan Kumar; Pal, Debashis; Kant, Deepender; Joshi, Lalit Mohan; Kumar, Bijendra; Meena, Rakesh; Rawat, Vikram [Microwave Tubes Division, CSIR-CEERI, Pilani, Rajasthan-333031 (India)

    2016-03-09

    Multi-beam Klystrons (MBKs) have gained wide acceptances in the research sector for its inherent advantages. But developing a robust tuning technique for an MBK cavity of coaxial type has still remained a challenge as these designs are very prone to suffer from asymmetric field distribution with inductive tuning of the cavity. Such asymmetry leads to inhomogeneous beam-wave interaction, an undesirable phenomenon. Described herein is a new type of coaxial cavity that has the ability to suppress the asymmetry, thereby allowing tuning of the cavity with a single tuning post.

  8. ON-LINE NONLINEAR CHROMATICITY CORRECTION USING OFF-MOMENTUM TUNE RESPONSE MATRIX

    International Nuclear Information System (INIS)

    LUO, Y.; FISCHER, W.; MALISKY, N.; TEPIKIAN, S.; TROBJEVIC, D.

    2007-01-01

    In this article, we propose a method for the online nonlinear chromaticity correction at store in the Relativistic Heavy Ion Collider (RHIC). With 8 arc sextupole families in each RHIC ring, the nonlinear chromaticities can be minimized online by matching the off-momentum tunes onto the wanted tunes given by the linear chromaticities. The Newton method is used for this multi-dimensional nonlinear optimization, where the off-momentum tune response matrix with respect to sextupole strength changes is adopted. The off-momentum tune response matrix can be calculated with the online accelerator optics model or directly measured with the real beam. In this article, the correction algorithm for the RHIC is presented. Simulations are also carried out to verify the method. The preliminary results from the beam experiments taken place in the RHIC 2007 Au run are reviewed

  9. Tornado-Shaped Curves

    Science.gov (United States)

    Martínez, Sol Sáez; de la Rosa, Félix Martínez; Rojas, Sergio

    2017-01-01

    In Advanced Calculus, our students wonder if it is possible to graphically represent a tornado by means of a three-dimensional curve. In this paper, we show it is possible by providing the parametric equations of such tornado-shaped curves.

  10. Parametrization of Combined Quantum Mechanical and Molecular Mechanical Methods: Bond-Tuned Link Atoms

    Directory of Open Access Journals (Sweden)

    Xin-Ping Wu

    2018-05-01

    Full Text Available Combined quantum mechanical and molecular mechanical (QM/MM methods are the most powerful available methods for high-level treatments of subsystems of very large systems. The treatment of the QM−MM boundary strongly affects the accuracy of QM/MM calculations. For QM/MM calculations having covalent bonds cut by the QM−MM boundary, it has been proposed previously to use a scheme with system-specific tuned fluorine link atoms. Here, we propose a broadly parametrized scheme where the parameters of the tuned F link atoms depend only on the type of bond being cut. In the proposed new scheme, the F link atom is tuned for systems with a certain type of cut bond at the QM−MM boundary instead of for a specific target system, and the resulting link atoms are call bond-tuned link atoms. In principle, the bond-tuned link atoms can be as convenient as the popular H link atoms, and they are especially well adapted for high-throughput and accurate QM/MM calculations. Here, we present the parameters for several kinds of cut bonds along with a set of validation calculations that confirm that the proposed bond-tuned link-atom scheme can be as accurate as the system-specific tuned F link-atom scheme.

  11. Parametrization of Combined Quantum Mechanical and Molecular Mechanical Methods: Bond-Tuned Link Atoms.

    Science.gov (United States)

    Wu, Xin-Ping; Gagliardi, Laura; Truhlar, Donald G

    2018-05-30

    Combined quantum mechanical and molecular mechanical (QM/MM) methods are the most powerful available methods for high-level treatments of subsystems of very large systems. The treatment of the QM-MM boundary strongly affects the accuracy of QM/MM calculations. For QM/MM calculations having covalent bonds cut by the QM-MM boundary, it has been proposed previously to use a scheme with system-specific tuned fluorine link atoms. Here, we propose a broadly parametrized scheme where the parameters of the tuned F link atoms depend only on the type of bond being cut. In the proposed new scheme, the F link atom is tuned for systems with a certain type of cut bond at the QM-MM boundary instead of for a specific target system, and the resulting link atoms are call bond-tuned link atoms. In principle, the bond-tuned link atoms can be as convenient as the popular H link atoms, and they are especially well adapted for high-throughput and accurate QM/MM calculations. Here, we present the parameters for several kinds of cut bonds along with a set of validation calculations that confirm that the proposed bond-tuned link-atom scheme can be as accurate as the system-specific tuned F link-atom scheme.

  12. Tune shift and betatron modulations due to insertion devices in SPEAR

    International Nuclear Information System (INIS)

    Corbett, W.J.

    1989-12-01

    SPEAR will soon operate as a dedicated synchrotron radiation source with up to 5 beamlines fed from insertion devices. These magnets introduce additional focusing forces into the storage ring lattice which increase the vertical betatron tune and modulate the beam envelope in the vertical plane. The lattice simulation code 'GEMINI' is used to evaluate the tune shifts and estimate the degree of betatron modulation as each magnetic insertion device is brought up to full power. A program is recommended to correct the tunes with the FODO cell quadrupoles. 4 refs., 8 figs., 1 tab

  13. Self-tuning regulator for an interacting CSTR process

    Science.gov (United States)

    Rajendra Mungale, Niraj; Upadhyay, Akshay; Jaganatha Pandian, B.

    2017-11-01

    In the paper we have laid emphasis on STR that is Self Tuning Regulator and its application for an interacting process. CSTR has a great importance in Chemical Process when we deal with controlling different parameters of a process using CSTR. Basically CSTR is used to maintain a constant liquid temperature in the process. The proposed method called self-tuning regulator, is a different scheme where process parameters are updated and the controller parameters are obtained from the solution of a design problem. The paper deals with STR and methods associated with it.

  14. PID controller tuning using the magnitude optimum criterion

    CERN Document Server

    Papadopoulos, Konstantinos

    2014-01-01

    An instructive reference that will help control researchers and engineers, interested in a variety of industrial processes, to take advantage of a powerful tuning method for the ever-popular PID control paradigm. This monograph presents explicit PID tuning rules for linear control loops regardless of process complexity. It shows the reader how such loops achieve zero steady-position, velocity, and acceleration errors and are thus able to track fast reference signals. The theoretical development takes place in the frequency domain by introducing a general-transfer-function-known process model

  15. Control System Design for Automatic Cavity Tuning Machines

    Energy Technology Data Exchange (ETDEWEB)

    Carcagno, R.; Khabiboulline, T.; Kotelnikov, S.; Makulski, A.; Nehring, R.; Nogiec, J.; Ross, M.; Schappert, W.; /Fermilab; Goessel, A.; Iversen, J.; Klinke, D.; /DESY

    2009-05-01

    A series of four automatic tuning machines for 9-cell TESLA-type cavities are being developed and fabricated in a collaborative effort among DESY, FNAL, and KEK. These machines are intended to support high-throughput cavity fabrication for construction of large SRF-based accelerator projects. Two of these machines will be delivered to cavity vendors for the tuning of XFEL cavities. The control system for these machines must support a high level of automation adequate for industrial use by non-experts operators. This paper describes the control system hardware and software design for these machines.

  16. Control System Design for Automatic Cavity Tuning Machines

    International Nuclear Information System (INIS)

    Carcagno, R.; Khabiboulline, T.; Kotelnikov, S.; Makulski, A.; Nehring, R.; Nogiec, J.; Ross, M.; Schappert, W.; Goessel, A.; Iversen, J.; Klinke, D.

    2009-01-01

    A series of four automatic tuning machines for 9-cell TESLA-type cavities are being developed and fabricated in a collaborative effort among DESY, FNAL, and KEK. These machines are intended to support high-throughput cavity fabrication for construction of large SRF-based accelerator projects. Two of these machines will be delivered to cavity vendors for the tuning of XFEL cavities. The control system for these machines must support a high level of automation adequate for industrial use by non-experts operators. This paper describes the control system hardware and software design for these machines.

  17. On the MSSM Higgsino mass and fine tuning

    CERN Document Server

    Ross, Graham G.

    2016-08-10

    It is often argued that low fine tuning in the MSSM necessarily requires a rather light Higgsino. In this note we show that this need not be the case when a more complete set of soft SUSY breaking mass terms are included. In particular an Higgsino mass term, that correlates the $\\mu-$term contribution with the soft SUSY-breaking Higgsino masses, significantly reduces the fine tuning even for Higgsinos in the TeV mass range where its relic abundance means it can make up all the dark matter.

  18. A resonant beam detector for TEVATRON tune monitoring

    International Nuclear Information System (INIS)

    Martin, D.; Fellenz, B.; Hood, C.; Johnson, M.; Shafer, R.; Siemann, R.; Zurawski, J.

    1989-03-01

    An inductively resonated, balanced stripline pickup has been constructed for observing tune spectra. The device is a sensitive betatron oscillation and Schottky noise pickup, providing 25 dB gain over untuned detectors of like geometry. The electrodes are motorized so the device center and aperture may be remotely adjusted. To tune the resonator onto the 21.4 MHz operating frequency, a motorized capacitor is employed. Quadrature signals from a pair of detectors has enabled observation of individual p and p coherent motions to nanometer levels. 8 refs., 5 figs

  19. A versatile curve-fit model for linear to deeply concave rank abundance curves

    NARCIS (Netherlands)

    Neuteboom, J.H.; Struik, P.C.

    2005-01-01

    A new, flexible curve-fit model for linear to concave rank abundance curves was conceptualized and validated using observational data. The model links the geometric-series model and log-series model and can also fit deeply concave rank abundance curves. The model is based ¿ in an unconventional way

  20. Neural network based approach for tuning of SNS feedback and feedforward controllers

    International Nuclear Information System (INIS)

    Kwon, Sung-Il; Prokop, Mark S.; Regan, Amy H.

    2002-01-01

    The primary controllers in the SNS low level RF system are proportional-integral (PI) feedback controllers. To obtain the best performance of the linac control systems, approximately 91 individual PI controller gains should be optimally tuned. Tuning is time consuming and requires automation. In this paper, a neural network is used for the controller gain tuning. A neural network can approximate any continuous mapping through learning. In a sense, the cavity loop PI controller is a continuous mapping of the tracking error and its one-sample-delay inputs to the controller output. Also, monotonic cavity output with respect to its input makes knowing the detailed parameters of the cavity unnecessary. Hence the PI controller is a prime candidate for approximation through a neural network. Using mean square error minimization to train the neural network along with a continuous mapping of appropriate weights, optimally tuned PI controller gains can be determined. The same neural network approximation property is also applied to enhance the adaptive feedforward controller performance. This is done by adjusting the feedforward controller gains, forgetting factor, and learning ratio. Lastly, the automation of the tuning procedure data measurement, neural network training, tuning and loading the controller gain to the DSP is addressed.

  1. Transcription-factor occupancy at HOT regions quantitatively predicts RNA polymerase recruitment in five human cell lines.

    KAUST Repository

    Foley, Joseph W; Sidow, Arend

    2013-01-01

    BACKGROUND: High-occupancy target (HOT) regions are compact genome loci occupied by many different transcription factors (TFs). HOT regions were initially defined in invertebrate model organisms, and we here show that they are a ubiquitous feature of the human gene-regulation landscape. RESULTS: We identified HOT regions by a comprehensive analysis of ChIP-seq data from 96 DNA-associated proteins in 5 human cell lines. Most HOT regions co-localize with RNA polymerase II binding sites, but many are not near the promoters of annotated genes. At HOT promoters, TF occupancy is strongly predictive of transcription preinitiation complex recruitment and moderately predictive of initiating Pol II recruitment, but only weakly predictive of elongating Pol II and RNA transcript abundance. TF occupancy varies quantitatively within human HOT regions; we used this variation to discover novel associations between TFs. The sequence motif associated with any given TF's direct DNA binding is somewhat predictive of its empirical occupancy, but a great deal of occupancy occurs at sites without the TF's motif, implying indirect recruitment by another TF whose motif is present. CONCLUSIONS: Mammalian HOT regions are regulatory hubs that integrate the signals from diverse regulatory pathways to quantitatively tune the promoter for RNA polymerase II recruitment.

  2. Transcription-factor occupancy at HOT regions quantitatively predicts RNA polymerase recruitment in five human cell lines.

    KAUST Repository

    Foley, Joseph W

    2013-10-20

    BACKGROUND: High-occupancy target (HOT) regions are compact genome loci occupied by many different transcription factors (TFs). HOT regions were initially defined in invertebrate model organisms, and we here show that they are a ubiquitous feature of the human gene-regulation landscape. RESULTS: We identified HOT regions by a comprehensive analysis of ChIP-seq data from 96 DNA-associated proteins in 5 human cell lines. Most HOT regions co-localize with RNA polymerase II binding sites, but many are not near the promoters of annotated genes. At HOT promoters, TF occupancy is strongly predictive of transcription preinitiation complex recruitment and moderately predictive of initiating Pol II recruitment, but only weakly predictive of elongating Pol II and RNA transcript abundance. TF occupancy varies quantitatively within human HOT regions; we used this variation to discover novel associations between TFs. The sequence motif associated with any given TF\\'s direct DNA binding is somewhat predictive of its empirical occupancy, but a great deal of occupancy occurs at sites without the TF\\'s motif, implying indirect recruitment by another TF whose motif is present. CONCLUSIONS: Mammalian HOT regions are regulatory hubs that integrate the signals from diverse regulatory pathways to quantitatively tune the promoter for RNA polymerase II recruitment.

  3. Orientation tuning of contrast masking caused by motion streaks.

    Science.gov (United States)

    Apthorp, Deborah; Cass, John; Alais, David

    2010-08-01

    We investigated whether the oriented trails of blur left by fast-moving dots (i.e., "motion streaks") effectively mask grating targets. Using a classic overlay masking paradigm, we varied mask contrast and target orientation to reveal underlying tuning. Fast-moving Gaussian blob arrays elevated thresholds for detection of static gratings, both monoptically and dichoptically. Monoptic masking at high mask (i.e., streak) contrasts is tuned for orientation and exhibits a similar bandwidth to masking functions obtained with grating stimuli (∼30 degrees). Dichoptic masking fails to show reliable orientation-tuned masking, but dichoptic masks at very low contrast produce a narrowly tuned facilitation (∼17 degrees). For iso-oriented streak masks and grating targets, we also explored masking as a function of mask contrast. Interestingly, dichoptic masking shows a classic "dipper"-like TVC function, whereas monoptic masking shows no dip and a steeper "handle". There is a very strong unoriented component to the masking, which we attribute to transiently biased temporal frequency masking. Fourier analysis of "motion streak" images shows interesting differences between dichoptic and monoptic functions and the information in the stimulus. Our data add weight to the growing body of evidence that the oriented blur of motion streaks contributes to the processing of fast motion signals.

  4. Genome-wide association study identifies TF as a significant modifier gene of iron metabolism in HFE hemochromatosis.

    Science.gov (United States)

    de Tayrac, Marie; Roth, Marie-Paule; Jouanolle, Anne-Marie; Coppin, Hélène; le Gac, Gérald; Piperno, Alberto; Férec, Claude; Pelucchi, Sara; Scotet, Virginie; Bardou-Jacquet, Edouard; Ropert, Martine; Bouvet, Régis; Génin, Emmanuelle; Mosser, Jean; Deugnier, Yves

    2015-03-01

    Hereditary hemochromatosis (HH) is the most common form of genetic iron loading disease. It is mainly related to the homozygous C282Y/C282Y mutation in the HFE gene that is, however, a necessary but not a sufficient condition to develop clinical and even biochemical HH. This suggests that modifier genes are likely involved in the expressivity of the disease. Our aim was to identify such modifier genes. We performed a genome-wide association study (GWAS) using DNA collected from 474 unrelated C282Y homozygotes. Associations were examined for both quantitative iron burden indices and clinical outcomes with 534,213 single nucleotide polymorphisms (SNP) genotypes, with replication analyses in an independent sample of 748 C282Y homozygotes from four different European centres. One SNP met genome-wide statistical significance for association with transferrin concentration (rs3811647, GWAS p value of 7×10(-9) and replication p value of 5×10(-13)). This SNP, located within intron 11 of the TF gene, had a pleiotropic effect on serum iron (GWAS p value of 4.9×10(-6) and replication p value of 3.2×10(-6)). Both serum transferrin and iron levels were associated with serum ferritin levels, amount of iron removed and global clinical stage (pHFE-associated HH (HFE-HH) patients, identified the rs3811647 polymorphism in the TF gene as the only SNP significantly associated with iron metabolism through serum transferrin and iron levels. Because these two outcomes were clearly associated with the biochemical and clinical expression of the disease, an indirect link between the rs3811647 polymorphism and the phenotypic presentation of HFE-HH is likely. Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  5. Beyond Fine Tuning: Adding capacity to leverage few labels

    Energy Technology Data Exchange (ETDEWEB)

    Hodas, Nathan O.; Shaffer, Kyle J.; Yankov, Artem; Corley, Courtney D.; Anderson, Aryk L.

    2017-12-09

    In this paper we present a technique to train neural network models on small amounts of data. Current methods for training neural networks on small amounts of rich data typically rely on strategies such as fine-tuning a pre-trained neural networks or the use of domain-specific hand-engineered features. Here we take the approach of treating network layers, or entire networks, as modules and combine pre-trained modules with untrained modules, to learn the shift in distributions between data sets. The central impact of using a modular approach comes from adding new representations to a network, as opposed to replacing representations via fine-tuning. Using this technique, we are able surpass results using standard fine-tuning transfer learning approaches, and we are also able to significantly increase performance over such approaches when using smaller amounts of data.

  6. Development and evaluation of a Gamma Camera tuning system

    International Nuclear Information System (INIS)

    Arista Romeu, E. J.; Diaz Garcia, A.; Osorio Deliz, J. F.

    2015-01-01

    Correct operation of conventional analogue Gamma Cameras implies a good conformation of the position signals that correspond to a specific photo-peak of the radionuclide of interest. In order to achieve this goal the energy spectrum from each photo multiplier tube (PMT) has to be set within the same energy window. For this reason a reliable tuning system is an important part of all gamma cameras processing systems. In this work is being tested and evaluated a new prototype of tuning card that was developed and setting up for this purpose. The hardware and software of the circuit allow the regulation if each PMT high voltage. By this means a proper gain control for each of them is accomplished. The Tuning Card prototype was simulated in a virtual model and its satisfactory operation was proven in a Siemens Orbiter Gamma Camera. (Author)

  7. Multimodal tuned dynamic absorber for split Stirling linear cryocooler

    Science.gov (United States)

    Veprik, A.; Tuito, A.

    2017-02-01

    Forthcoming low size, weight, power and price split Stirling linear cryocoolers may rely on electro-dynamically driven single-piston compressors and pneumatically driven expanders interconnected by the configurable transfer line. For compactness, compressor and expander units may be placed in a side-by-side manner, thus producing tonal vibration export comprising force and moment components. In vibration sensitive applications, this may result in excessive angular line of sight jitter and translational defocusing affecting the image quality. The authors present Multimodal Tuned Dynamic Absorber (MTDA), having one translational and two tilting modes essentially tuned to the driving frequency. The dynamic reactions (force and moment) produced by such a MTDA are simultaneously counterbalancing force and moment vibration export produced by the cryocooler. The authors reveal the design details, the method of fine modal tuning and outcomes of numerical simulation on attainable performance.

  8. Strings on a Violin: Location Dependence of Frequency Tuning in Active Dendrites.

    Science.gov (United States)

    Das, Anindita; Rathour, Rahul K; Narayanan, Rishikesh

    2017-01-01

    Strings on a violin are tuned to generate distinct sound frequencies in a manner that is firmly dependent on finger location along the fingerboard. Sound frequencies emerging from different violins could be very different based on their architecture, the nature of strings and their tuning. Analogously, active neuronal dendrites, dendrites endowed with active channel conductances, are tuned to distinct input frequencies in a manner that is dependent on the dendritic location of the synaptic inputs. Further, disparate channel expression profiles and differences in morphological characteristics could result in dendrites on different neurons of the same subtype tuned to distinct frequency ranges. Alternately, similar location-dependence along dendritic structures could be achieved through disparate combinations of channel profiles and morphological characteristics, leading to degeneracy in active dendritic spectral tuning. Akin to strings on a violin being tuned to different frequencies than those on a viola or a cello, different neuronal subtypes exhibit distinct channel profiles and disparate morphological characteristics endowing each neuronal subtype with unique location-dependent frequency selectivity. Finally, similar to the tunability of musical instruments to elicit distinct location-dependent sounds, neuronal frequency selectivity and its location-dependence are tunable through activity-dependent plasticity of ion channels and morphology. In this morceau, we explore the origins of neuronal frequency selectivity, and survey the literature on the mechanisms behind the emergence of location-dependence in distinct forms of frequency tuning. As a coda to this composition, we present some future directions for this exciting convergence of biophysical mechanisms that endow a neuron with frequency multiplexing capabilities.

  9. The nonlinear Maxwell-type model for viscoelastoplastic materials: simulation of temperature influence on creep, relaxation and strain-stress curves

    Directory of Open Access Journals (Sweden)

    Andrew V. Khokhlov

    2017-04-01

    Full Text Available The nonlinear Maxwell-type constitutive relation with two arbitrary material functions for viscoelastoplastic multi-modulus materials is studied analytically in uniaxial isothermic case to reveal the model abilities and applicability scope and to develop techniques of its identification, tuning and fitting. The constitutive equation is aimed at adequate modeling of the rheological phenomena set which is typical for reonomic materials exhibiting non-linear hereditary properties, strong strain rate sensitivity, secondary creep, yielding at constant stress, tension compression asymmetry and such temperature effects as increase of material compliance, strain rate sensitivity and rates of dissipation, relaxation, creep and plastic strain accumulation with temperature growth. The model is applicable for simulation of mechanical behaviour of various polymers, their solutions and melts, solid propellants, sand-asphalt concretes, composite materials, titanium and aluminum alloys, ceramics at high temperature and so on. To describe the influence of temperature on material mechanical behavior (under isothermic conditions, two scalar material parameters of the model (viscosity coefficient and “modulus of elasticity” are considered as a functions of temperature level. The general restrictions on their properties which are necessary and sufficient for adequate qualitative description of the basic thermomechanical phenomena related to typical temperature influence on creep and relaxation curves, creep recovery curves, creep curves under step-wise loading and quasi-static stress-strain curves of viscoelastoplastic materials are obtained. The restrictions are derived using systematic analytical study of general qualitative features of the theoretic creep and relaxation curves, creep curves under step-wise loading, long-term strength curves and stress-strain curves at constant strain or stress rates generated by the constitutive equation (under minimal

  10. Betatron tune correction schemes in nuclotron

    International Nuclear Information System (INIS)

    Shchepunov, V.A.

    1992-01-01

    Algorithms of the betatron tune corrections in Nuclotron with sextupolar and octupolar magnets are considered. Second order effects caused by chromaticity correctors are taken into account and sextupolar compensation schemes are proposed to suppress them. 6 refs.; 1 tab

  11. In-Vehicle Dynamic Curve-Speed Warnings at High-Risk Rural Curves

    Science.gov (United States)

    2018-03-01

    Lane-departure crashes at horizontal curves represent a significant portion of fatal crashes on rural Minnesota roads. Because of this, solutions are needed to aid drivers in identifying upcoming curves and inform them of a safe speed at which they s...

  12. Tuning History in Latin America

    Science.gov (United States)

    Velázquez Albo, Marco

    2017-01-01

    This article analyses the development and achievements of the area of History in the Tuning-Latin America Project from its launch in 2004 to its completion in 2013. Through two phases and nine general meetings, academics from Argentina, Brazil, Chile, Colombia, Costa Rica, Cuba, Guatemala, Mexico and Peru, along with academics from Spain, Portugal…

  13. Veterinary applications of ionising radiation HERCA Task Force on Veterinary Applications. Main results of the Questionnaire 'National regulatory requirements with regard to veterinary medical applications of ionising radiation' and conclusions of the TF

    International Nuclear Information System (INIS)

    Van Bladel, Lodewijk; Berlamont, Jolien; Michalczak, Herbert; Balogh, Lajos; Peremans, Kathelijne

    2013-11-01

    In the fall of 2012, the subject of radiation protection in veterinary medicine was raised during the meeting of the HERCA Board. Issues with regard to this subject had been brought to the attention of HERCA by the European College of Veterinary Diagnostic Imaging (ECVDI). In October 2012, the Board decided to charge a small Task Force (TF) to further explore the issues in this field. This TF drew up a questionnaire which looked at the general radiation protection regulatory requirements in veterinary medicine applications of ionizing radiation. The results of this study showed large differences in the requirements applicable in the HERCA member countries. The TF also noticed the increasing use of more complex imaging procedures and of different radio-therapeutic modalities, which may imply greater risks of exposure of humans to ionising radiation. These results were presented during the HERCA Board meeting in Berlin, Germany and on which the Board decided to establish a Working Group on veterinary applications of ionising radiations (WG Vet). The main results of the Questionnaire 'National regulatory requirements with regard to veterinary medicine applications of ionising radiation' is attached in Appendix

  14. Au nanoparticles decorated SiO{sub 2} nanowires by dewetting on curved surfaces: facile synthesis and nanoparticles-nanowires sizes correlation

    Energy Technology Data Exchange (ETDEWEB)

    Ruffino, F., E-mail: francesco.ruffino@ct.infn.it; Grimaldi, M. G. [Universita di Catania, Dipartimento di Fisica e Astronomia (Italy)

    2013-09-15

    We report a solid-state synthesis for SiO{sub 2} nanowires (NWs) (up to 20 microns in length and from about 40 to about 150 nm in diameter) coated by Au nanoparticles (NPs) (from about 20 to about 80 nm in diameter). This protocol is based on three steps: (1) large area production of very long SiO{sub 2} NWs on a Si surface exploiting a simple Au/Si solid-state reaction at high temperature; (2) coating of the SiO{sub 2} NWs by a Au film of desired thickness using sputtering depositions; and (3) a thermal process to induce a dewetting process of the Au-film coating the SiO{sub 2} NWs to obtain Au NPs on the curved surface of the NWs. The morphology evolution of the SiO{sub 2} NWs was followed, in each step, by scanning electron microscopy analyses. They allowed to correlate the evolution of the NPs size with the NWs sizes for different thicknesses of the starting Au-film coating the NWs and different annealing temperatures of the dewetting process. Some theoretical concepts, related to the dewetting process of a film on a curved surface were used to describe the experimental data. The main advantages of the proposed protocols include: (i) simplicity and low-cost (it is based only on sputtering depositions and thermal processes), and (ii) versatility based on the possibility of tuning Au-film thickness and annealing temperature to tune the NPs-NWs sizes ratio. These advantages can make this technique suitable for the mass production of Au NPs-coated SiO{sub 2} NWs toward applications in electronic devices, biosensors, and nanoscale optical devices.

  15. Improving the Fine-Tuning of Metaheuristics: An Approach Combining Design of Experiments and Racing Algorithms

    Directory of Open Access Journals (Sweden)

    Eduardo Batista de Moraes Barbosa

    2017-01-01

    Full Text Available Usually, metaheuristic algorithms are adapted to a large set of problems by applying few modifications on parameters for each specific case. However, this flexibility demands a huge effort to correctly tune such parameters. Therefore, the tuning of metaheuristics arises as one of the most important challenges in the context of research of these algorithms. Thus, this paper aims to present a methodology combining Statistical and Artificial Intelligence methods in the fine-tuning of metaheuristics. The key idea is a heuristic method, called Heuristic Oriented Racing Algorithm (HORA, which explores a search space of parameters looking for candidate configurations close to a promising alternative. To confirm the validity of this approach, we present a case study for fine-tuning two distinct metaheuristics: Simulated Annealing (SA and Genetic Algorithm (GA, in order to solve the classical traveling salesman problem. The results are compared considering the same metaheuristics tuned through a racing method. Broadly, the proposed approach proved to be effective in terms of the overall time of the tuning process. Our results reveal that metaheuristics tuned by means of HORA achieve, with much less computational effort, similar results compared to the case when they are tuned by the other fine-tuning approach.

  16. A coil test facility for the cryogenic tests of the JT-60SA TF coils

    International Nuclear Information System (INIS)

    Chantant, M.; Genini, L.; Bayetti, P.; Millet, F.; Wanner, M.; Massaut, V.; Corte, A. Della; Ardelier-Desage, F.; Catherine-Dumont, V.; Dael, A.; Decool, P.; Donati, A.; Duchateau, J.L.; Garibaldi, P.; Girard, S.; Hatchressian, J.C.; Fejoz, P.; Jamotton, P.; Jourdheuil, L.; Juster, F.P.

    2011-01-01

    In the framework of the Broader Approach Activities, the EU will deliver to Japan the 18 superconducting coils, which constitute the JT-60SA Toroidal field magnet. These 18 coils, manufactured by France and Italy, will be cold tested before shipping to Japan. For this purpose, the European Joint Undertaking for ITER, the Development of Fusion Energy ('Fusion for Energy', F4E) and the European Voluntary Contributors are collaborating to design and set-up a coil test facility (CTF) and to perform the acceptance test of the 18 JT-60SA Toroidal Field (TF) coils. The test facility is designed to test one coil at a time at nominal current and cryogenic temperature. The test of the first coil of each manufacturer includes a quench triggered by increasing the temperature. The project is presently in the detailed design phase.

  17. Parameters Tuning of Model Free Adaptive Control Based on Minimum Entropy

    Institute of Scientific and Technical Information of China (English)

    Chao Ji; Jing Wang; Liulin Cao; Qibing Jin

    2014-01-01

    Dynamic linearization based model free adaptive control(MFAC) algorithm has been widely used in practical systems, in which some parameters should be tuned before it is successfully applied to process industries. Considering the random noise existing in real processes, a parameter tuning method based on minimum entropy optimization is proposed,and the feature of entropy is used to accurately describe the system uncertainty. For cases of Gaussian stochastic noise and non-Gaussian stochastic noise, an entropy recursive optimization algorithm is derived based on approximate model or identified model. The extensive simulation results show the effectiveness of the minimum entropy optimization for the partial form dynamic linearization based MFAC. The parameters tuned by the minimum entropy optimization index shows stronger stability and more robustness than these tuned by other traditional index,such as integral of the squared error(ISE) or integral of timeweighted absolute error(ITAE), when the system stochastic noise exists.

  18. PERI - auto-tuning memory-intensive kernels for multicore

    International Nuclear Information System (INIS)

    Williams, S; Carter, J; Oliker, L; Shalf, J; Yelick, K; Bailey, D; Datta, K

    2008-01-01

    We present an auto-tuning approach to optimize application performance on emerging multicore architectures. The methodology extends the idea of search-based performance optimizations, popular in linear algebra and FFT libraries, to application-specific computational kernels. Our work applies this strategy to sparse matrix vector multiplication (SpMV), the explicit heat equation PDE on a regular grid (Stencil), and a lattice Boltzmann application (LBMHD). We explore one of the broadest sets of multicore architectures in the high-performance computing literature, including the Intel Xeon Clovertown, AMD Opteron Barcelona, Sun Victoria Falls, and the Sony-Toshiba-IBM (STI) Cell. Rather than hand-tuning each kernel for each system, we develop a code generator for each kernel that allows us identify a highly optimized version for each platform, while amortizing the human programming effort. Results show that our auto-tuned kernel applications often achieve a better than 4x improvement compared with the original code. Additionally, we analyze a Roofline performance model for each platform to reveal hardware bottlenecks and software challenges for future multicore systems and applications

  19. PERI - Auto-tuning Memory Intensive Kernels for Multicore

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H; Williams, Samuel; Datta, Kaushik; Carter, Jonathan; Oliker, Leonid; Shalf, John; Yelick, Katherine; Bailey, David H

    2008-06-24

    We present an auto-tuning approach to optimize application performance on emerging multicore architectures. The methodology extends the idea of search-based performance optimizations, popular in linear algebra and FFT libraries, to application-specific computational kernels. Our work applies this strategy to Sparse Matrix Vector Multiplication (SpMV), the explicit heat equation PDE on a regular grid (Stencil), and a lattice Boltzmann application (LBMHD). We explore one of the broadest sets of multicore architectures in the HPC literature, including the Intel Xeon Clovertown, AMD Opteron Barcelona, Sun Victoria Falls, and the Sony-Toshiba-IBM (STI) Cell. Rather than hand-tuning each kernel for each system, we develop a code generator for each kernel that allows us to identify a highly optimized version for each platform, while amortizing the human programming effort. Results show that our auto-tuned kernel applications often achieve a better than 4X improvement compared with the original code. Additionally, we analyze a Roofline performance model for each platform to reveal hardware bottlenecks and software challenges for future multicore systems and applications.

  20. Tuning Parameters in Heuristics by Using Design of Experiments Methods

    Science.gov (United States)

    Arin, Arif; Rabadi, Ghaith; Unal, Resit

    2010-01-01

    With the growing complexity of today's large scale problems, it has become more difficult to find optimal solutions by using exact mathematical methods. The need to find near-optimal solutions in an acceptable time frame requires heuristic approaches. In many cases, however, most heuristics have several parameters that need to be "tuned" before they can reach good results. The problem then turns into "finding best parameter setting" for the heuristics to solve the problems efficiently and timely. One-Factor-At-a-Time (OFAT) approach for parameter tuning neglects the interactions between parameters. Design of Experiments (DOE) tools can be instead employed to tune the parameters more effectively. In this paper, we seek the best parameter setting for a Genetic Algorithm (GA) to solve the single machine total weighted tardiness problem in which n jobs must be scheduled on a single machine without preemption, and the objective is to minimize the total weighted tardiness. Benchmark instances for the problem are available in the literature. To fine tune the GA parameters in the most efficient way, we compare multiple DOE models including 2-level (2k ) full factorial design, orthogonal array design, central composite design, D-optimal design and signal-to-noise (SIN) ratios. In each DOE method, a mathematical model is created using regression analysis, and solved to obtain the best parameter setting. After verification runs using the tuned parameter setting, the preliminary results for optimal solutions of multiple instances were found efficiently.

  1. Room Temperature Magnetic Determination of the Current Center Line for the ITER TF Coils

    CERN Document Server

    Lerch, Philippe; Buzio, Marco; Negrazus, Marco; Baynham, Elwyn; Sanfilippo, Stephane; Foussat, Arnaud

    2014-01-01

    The ITER tokamak includes 18 superconducting D-shaped toroidal field (IT) coils. Unavoidable shape deformations as well as assembly errors will lead to field errors, which can be modeled with the knowledge of the current center line (CCL). Accurate survey during the entire manufacturing and assembly process, including transfer of survey points, is complex. In order to increase the level of confidence, a room temperature magnetic measurement of the CCL on assembled and closed winding packs is foreseen, prior to insertion into their cold case. In this contribution, we discuss the principle of the CCL determination and present a low frequency ac measurement system under development at PSI, within an ITER framework contract. The largest current allowed to flow in the TF coil at room temperature and the precision requirements for the determination of the CCL loci of the coil are hard boundaries. Eddy currents in the radial plates, the winding pack enclosures, and possibly from iron in the reinforced concrete floor...

  2. Historic Learning Approach for Auto-tuning OpenACC Accelerated Scientific Applications

    KAUST Repository

    Siddiqui, Shahzeb; Alzayer, Fatemah; Feki, Saber

    2015-01-01

    on a given system. A historic learning based methodology is suggested to prune the parameter search space for a more efficient auto-tuning process. This approach is applied to tune the OpenACC gang and vector clauses for a better mapping of the compute

  3. High-pressure solubility of carbon dioxide in pyrrolidinium-based ionic liquids: [bmpyr][dca] and [bmpyr][Tf{sub 2}N

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung-Chul; Nam, Sang Gyu [Hannam University, Daejeon (Korea, Republic of)

    2015-03-15

    Solubility data of carbon dioxide (CO{sub 2}) in two pyrrolidinium-based ionic liquids: 1-butyl-1-methylpyrrolidinium dicyanamide ([bmpyr][dca]) and 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ([bmpyr] [Tf{sub 2}N]) are presented at pressures up to about 30MPa and temperatures from 303..2 K to 343.2 K. The solubility was determined by measuring bubble or cloud point pressures of mixtures of CO{sub 2} and ionic liquid using a high-pressure equilibrium apparatus equipped with a variable-volume view cell. The CO{sub 2} solubility in the ionic liquid in terms of the mole fraction or the molality increased with the increase of the equilibrium pressure at a given temperature, but decreased with the increase of temperature at a given pressure. At a given temperature, the mole fraction of CO{sub 2} dissolved in the ionic liquid increased rapidly as pressure increased. CO{sub 2} solubility in the mole fraction almost reached saturation around 0.65 for [bmpyr][dca] and around 0..8 for [bmpyr][Tf{sub 2}N], respectively. The experimental data for the CO{sub 2}+ionic liquid systems were correlated using the Peng-Robinson equation of state (PR-EoS). The mixing rules of the Wong-Sandler type rather than the classical mixing rules of the van der Waals type were coupled with the PR-EoS. The resulting modeling approach proved to be able to correlate the CO{sub 2} solubilities in aforementioned ionic liquids over the aforementioned range of temperature and pressure within 5% average deviations.

  4. ZIF-8 gate tuning via terminal group modification: a computational study

    KAUST Repository

    Zheng, Bin

    2016-06-24

    Tuning the pore structure of zeolitic imidazolate frameworks (ZIFs) enables unique control of their material properties. In this work, we used computational methods to examine the gate structure of ZIF-8 tuned by substitution terminal groups. The substitution position and electron affinity of the added groups were shown to be key factors in gate size. Electrostatic interactions are responsible for the variation in gate opening. These results suggest that the post-modification of terminal group in ZIFs can be used to finely tune the pore gate, opening up new strategies in the design of ZIFs with desired properties.

  5. Political Tunings of the Piano

    DEFF Research Database (Denmark)

    Højlund, Marie Koldkjær; Riis, Morten S.

    According to Timothy Morton the creation of ambient art posses an inherent critical potential similar to the ambiguity of the dialectical image found in the writings of Walter Benjamin. Subscribing to an object-oriented ontological understanding of how objects are riven between essence and appear......) as unfolding the ambiguity of various political tunings of the piano....

  6. Can an Eternal Life Start From the Minimal Fine-Tuning for Intelligence?

    Directory of Open Access Journals (Sweden)

    Ward Blondé

    2016-10-01

    Full Text Available Since modern physicists made more and more advances in precisely measuring the fundamental constants in nature, cosmologists have been confronted with this problem: how do we declare that nature’s constants are fine-tuned for the emergence of life? Many cosmologists assume nowadays that the big bang universe originates from a multiverse that consists of very many universes. Some of these must be fine-tuned for life. A fascinating question arises: Would there be any chance on a life after our death in this multiverse? In this paper, I show two things about the multiverse. First, universes in the multiverse acquire an unlimited amount of additional fine-tuning for intelligent life over the course of many universe generations. Such additional fine-tuning may consist of travelling between universes and an afterlife on a distant planet. Second, evolutionary conservation in the evolution of universes in the multiverse provides a declaration why we observe a universe that roughly has the minimal fine-tuning to support intelligent life.

  7. Tuned mass absorbers on damped structures under random load

    DEFF Research Database (Denmark)

    Krenk, Steen; Høgsberg, Jan Becker

    2008-01-01

    the mass ratio alone, and the damping can be determined subsequently. Only approximate results are available for the influence of damping in the original structure, typically in the form of series expansions. In the present paper it is demonstrated that for typical mass ratios in the order of a few percent......A substantial literature exists on the optimal choice of parameters of a tuned mass absorber on a structure excited by a force or by ground acceleration with random characteristics in the form of white noise. In the absence of structural damping the optimal frequency tuning is determined from...... for the response variance of a structure with initial damping in terms of the mass ratio and both damping ratios. Within this format the optimal tuning of the absorber turns out to be independent of the structural damping, and a simple explicit expression is obtained for the equivalent total damping....

  8. Phosphatase activity tunes two-component system sensor detection threshold.

    Science.gov (United States)

    Landry, Brian P; Palanki, Rohan; Dyulgyarov, Nikola; Hartsough, Lucas A; Tabor, Jeffrey J

    2018-04-12

    Two-component systems (TCSs) are the largest family of multi-step signal transduction pathways in biology, and a major source of sensors for biotechnology. However, the input concentrations to which biosensors respond are often mismatched with application requirements. Here, we utilize a mathematical model to show that TCS detection thresholds increase with the phosphatase activity of the sensor histidine kinase. We experimentally validate this result in engineered Bacillus subtilis nitrate and E. coli aspartate TCS sensors by tuning their detection threshold up to two orders of magnitude. We go on to apply our TCS tuning method to recently described tetrathionate and thiosulfate sensors by mutating a widely conserved residue previously shown to impact phosphatase activity. Finally, we apply TCS tuning to engineer B. subtilis to sense and report a wide range of fertilizer concentrations in soil. This work will enable the engineering of tailor-made biosensors for diverse synthetic biology applications.

  9. The curve shortening problem

    CERN Document Server

    Chou, Kai-Seng

    2001-01-01

    Although research in curve shortening flow has been very active for nearly 20 years, the results of those efforts have remained scattered throughout the literature. For the first time, The Curve Shortening Problem collects and illuminates those results in a comprehensive, rigorous, and self-contained account of the fundamental results.The authors present a complete treatment of the Gage-Hamilton theorem, a clear, detailed exposition of Grayson''s convexity theorem, a systematic discussion of invariant solutions, applications to the existence of simple closed geodesics on a surface, and a new, almost convexity theorem for the generalized curve shortening problem.Many questions regarding curve shortening remain outstanding. With its careful exposition and complete guide to the literature, The Curve Shortening Problem provides not only an outstanding starting point for graduate students and new investigations, but a superb reference that presents intriguing new results for those already active in the field.

  10. PID controller tuning using metaheuristic optimization algorithms for benchmark problems

    Science.gov (United States)

    Gholap, Vishal; Naik Dessai, Chaitali; Bagyaveereswaran, V.

    2017-11-01

    This paper contributes to find the optimal PID controller parameters using particle swarm optimization (PSO), Genetic Algorithm (GA) and Simulated Annealing (SA) algorithm. The algorithms were developed through simulation of chemical process and electrical system and the PID controller is tuned. Here, two different fitness functions such as Integral Time Absolute Error and Time domain Specifications were chosen and applied on PSO, GA and SA while tuning the controller. The proposed Algorithms are implemented on two benchmark problems of coupled tank system and DC motor. Finally, comparative study has been done with different algorithms based on best cost, number of iterations and different objective functions. The closed loop process response for each set of tuned parameters is plotted for each system with each fitness function.

  11. Tuning Ice Nucleation with Supercharged Polypeptides

    NARCIS (Netherlands)

    Yang, Huige; Ma, Chao; Li, Kaiyong; Liu, Kai; Loznik, Mark; Teeuwen, Rosalie; van Hest, Jan C. M.; Zhou, Xin; Herrmann, Andreas; Wang, Jianjun

    2016-01-01

    Supercharged unfolded polypeptides (SUPs) are exploited for controlling ice nucleation via tuning the nature of charge and charge density of SUPs. The results show that positively charged SUPs facilitate ice nucleation, while negatively charged ones suppress it. Moreover, the charge density of the

  12. Tilt-tuned etalon locking for tunable laser stabilization.

    Science.gov (United States)

    Gibson, Bradley M; McCall, Benjamin J

    2015-06-15

    Locking to a fringe of a tilt-tuned etalon provides a simple, inexpensive method for stabilizing tunable lasers. Here, we describe the use of such a system to stabilize an external-cavity quantum cascade laser; the locked laser has an Allan deviation of approximately 1 MHz over a one-second integration period, and has a single-scan tuning range of approximately 0.4  cm(-1). The system is robust, with minimal alignment requirements and automated lock acquisition, and can be easily adapted to different wavelength regions or more stringent stability requirements with minor alterations.

  13. RESONANT BPM FOR CONTINUOUS TUNE MEASUREMENT IN RHIC

    International Nuclear Information System (INIS)

    KESSELMAN, M.; CAMERON, P.; CUPOLO, J.

    2001-01-01

    A movable Beam Position Monitor (BPM) using shorted stripline Pick-Up Electrode (NE) elements has been resonated using matching stub techniques to achieve a relatively high Q resonance at about 230MHz. This PUE has been used in a feasibility study of phase-locked-loop tune measurement [1], using a lock-in amplifier and variable frequency generator to continuously track betatron tune in RHIC, as well as to observe Schottky signals of the Gold beam. The approach to providing a high Q PUE for difference mode signals, simulation studies, and the results of initial tests will be presented

  14. Active tuned mass damper for damping of offshore wind turbine vibrations

    DEFF Research Database (Denmark)

    Brodersen, Mark Laier; Bjørke, Ann-Sofie; Høgsberg, Jan Becker

    2017-01-01

    An active tuned mass damper (ATMD) is employed for damping of tower vibrations of fixed offshore wind turbines, where the additional actuator force is controlled using feedback from the tower displacement and the relative velocity of the damper mass. An optimum tuning procedure equivalent to the ...

  15. I Tune, You Tube, We Rule

    Science.gov (United States)

    Shida, R. Y.; Gater, W.

    2007-10-01

    The website YouTube was created in 2005 and has rapidly become one of the most popular entertainment websites on the internet. It is riding the online video wave today like few other online companies and is currently more popular than the video sections of either Yahoo or Google. iTunes, a digital media application created by Apple in 2001, where one can download and play music and videos, has had a similar success. There is little doubt that they both represent important communication channels in a world heavily influenced by online media, especially among teenagers and young adults. As science communicators we can use this direct route to a younger audience to our advantage. This article aims to give a taste of these applications with a few selected examples demonstrating that both YouTube and iTunes are excellent tools to teach and inspire the general public.

  16. I Tune, You Tube, We Rule

    Directory of Open Access Journals (Sweden)

    Shida, R. Y.

    2007-10-01

    Full Text Available The website YouTube was created in 2005 and has rapidly become one ofthe most popular entertainment websites on the internet. It is riding the online video wave today like few other online companies and is currently more popular than the video sections of either Yahoo or Google. iTunes, a digital media application created by Apple in 2001, where one can download and play music and videos, has had a similar success. There is little doubt that they both represent important communication channels in a world heavily influenced by online media, especially among teenagers and young adults. As science communicators we can use this direct route to a younger audience to our advantage. This article aims to give a taste of these applications with a fewselected examples demonstrating that both YouTube and iTunes are excellent tools to teach and inspire the general public.

  17. Developing reflection on competence-based learning: the Russian experience with the Tuning approach

    Directory of Open Access Journals (Sweden)

    Anna Serbati

    2014-07-01

    Full Text Available The paper focuses on the Tuning Russia project. It aims at providing an overview of the impact of the Tuning methodology and outcomes concerning University teaching, learning, and assessment activities. It identifies: the most relevant results and “lesson learnt” during the project; tools/concepts/experiences that involved teachers found most interesting; strengths and weaknesses; the usefulness of working with colleagues from different Russian universities; and the level of sharing of the Tuning methodology with other colleagues within participating Universities. The empirical data for the study were drawn from a qualitative questionnaire with open questions filled-in by the members of the subject area group “Social Work” involved in the Tuning Russia project. The respondents were six academic teachers from different Russian universities and two European Tuning experts. This reflection by academic teachers upon the initial implementation of the Tuning approach in Russia highlights the opportunities to explore methods of establishing and improving communities of practice in the field of competence-based higher education curriculum development. Results highlight the need to develop further work concerning both summative and formative evaluation in relation to competence-based curricula review in higher education

  18. Thermo-optically tuned photonic resonators with concurrent electrical connection and thermal isolation

    Science.gov (United States)

    Lentine, Anthony L.; Kekatpure, Rohan Deodatta; Zortman, William A.; Savignon, Daniel J.

    2016-06-14

    A photonic resonator system is designed to use thermal tuning to adjust the resonant wavelength of each resonator in the system, with a separate tuning circuit associated with each resonator so that individual adjustments may be made. The common electrical ground connection between the tuning circuits is particularly formed to provide thermal isolation between adjacent resonators by including a capacitor along each return path to ground, where the presence of the capacitor's dielectric material provides the thermal isolation. The use of capacitively coupling necessarily requires the use of an AC current as an input to the heater element (conductor/resistor) of each resonator, where the RMS value of the AC signal is indicative of the amount of heat that is generated along the element and the degree of wavelength tuning that is obtained.

  19. The fine-tuning cost of the likelihood in SUSY models

    CERN Document Server

    Ghilencea, D M

    2013-01-01

    In SUSY models, the fine tuning of the electroweak (EW) scale with respect to their parameters gamma_i={m_0, m_{1/2}, mu_0, A_0, B_0,...} and the maximal likelihood L to fit the experimental data are usually regarded as two different problems. We show that, if one regards the EW minimum conditions as constraints that fix the EW scale, this commonly held view is not correct and that the likelihood contains all the information about fine-tuning. In this case we show that the corrected likelihood is equal to the ratio L/Delta of the usual likelihood L and the traditional fine tuning measure Delta of the EW scale. A similar result is obtained for the integrated likelihood over the set {gamma_i}, that can be written as a surface integral of the ratio L/Delta, with the surface in gamma_i space determined by the EW minimum constraints. As a result, a large likelihood actually demands a large ratio L/Delta or equivalently, a small chi^2_{new}=chi^2_{old}+2*ln(Delta). This shows the fine-tuning cost to the likelihood ...

  20. A novel auto-tuning PID control mechanism for nonlinear systems.

    Science.gov (United States)

    Cetin, Meric; Iplikci, Serdar

    2015-09-01

    In this paper, a novel Runge-Kutta (RK) discretization-based model-predictive auto-tuning proportional-integral-derivative controller (RK-PID) is introduced for the control of continuous-time nonlinear systems. The parameters of the PID controller are tuned using RK model of the system through prediction error-square minimization where the predicted information of tracking error provides an enhanced tuning of the parameters. Based on the model-predictive control (MPC) approach, the proposed mechanism provides necessary PID parameter adaptations while generating additive correction terms to assist the initially inadequate PID controller. Efficiency of the proposed mechanism has been tested on two experimental real-time systems: an unstable single-input single-output (SISO) nonlinear magnetic-levitation system and a nonlinear multi-input multi-output (MIMO) liquid-level system. RK-PID has been compared to standard PID, standard nonlinear MPC (NMPC), RK-MPC and conventional sliding-mode control (SMC) methods in terms of control performance, robustness, computational complexity and design issue. The proposed mechanism exhibits acceptable tuning and control performance with very small steady-state tracking errors, and provides very short settling time for parameter convergence. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  1. Tuning Features of Chinese Folk Song Singing: A Case Study of Hua'er Music.

    Science.gov (United States)

    Yang, Yang; Welch, Graham; Sundberg, Johan; Himonides, Evangelos

    2015-07-01

    The learning and teaching of different singing styles, such as operatic and Chinese folk singing, was often found to be very challenging in professional music education because of the complexity of varied musical properties and vocalizations. By studying the acoustical and musical parameters of the singing voice, this study identified distinctive tuning characteristics of a particular folk music in China-Hua'er music-to inform the ineffective folk singing practices, which were hampered by the neglect of inherent tuning issues in music. Thirteen unaccompanied folk song examples from four folk singers were digitally audio recorded in a sound studio. Using an analyzing toolkit consisting of Praat, PeakFit, and MS Excel, the fundamental frequencies (F0) of these song examples were extracted into sets of "anchor pitches" mostly used, which were further divided into 253 F0 clusters. The interval structures of anchor pitches within each song were analyzed and then compared across 13 examples providing parameters that indicate the tuning preference of this particular singing style. The data analyses demonstrated that all singers used a tuning pattern consisting of five major anchor pitches suggesting a nonequal-tempered bias in singing. This partly verified the pentatonic scale proposed in previous empirical research but also argued a potential misunderstanding of the studied folk music scale that failed to take intrinsic tuning issues into consideration. This study suggests that, in professional music training, any tuning strategy should be considered in terms of the reference pitch and likely tuning systems. Any accompanying instruments would need to be tuned to match the underlying tuning bias. Copyright © 2015 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  2. BOREAS TF-10 NSA-YJP Tower Flux, Meteorological, and Porometry Data

    Science.gov (United States)

    McCaughey, J. Harry; Liblik, Laura; Hall, Forrest G. (Editor); Huemmrich, K. (Editor)

    2000-01-01

    The BOREAS TF-10 team collected tower flux and meteorological data at two sites, a fen and a young jack pine forest, near Thompson, Manitoba, Canada, as part of BOREAS. A preliminary data set was assembled in August 1993 while field testing the instrument packages, and at both sites data were collected from 15-Aug to 31-Aug. The main experimental period was in 1994, when continuous data were collected from the young jack pine site from 23-May to 20-Sep. Upon examination of the 1994 data set, it became clear that the behavior of the heat, water, and carbon dioxide fluxes throughout the whole growing season was an important scientific question, and that the 1994 data record was not sufficiently long to capture the character of the seasonal behavior of the fluxes. Thus, the young jack pine site was operated from 08-May to 07-Nov in 1996 in order to collect data from spring melt to autumn freeze-up. All variables are presented as 30-minute averages. Supporting data were also collected to describe the surface#s state and to provide the information, in association with the flux data, to build SVAT models. For the young jack pine site, these supporting data included stomatal conductance measurements. The data are stored in tabular ASCII files.

  3. Development of Tuning Fork Based Probes for Atomic Force Microscopy

    Science.gov (United States)

    Jalilian, Romaneh; Yazdanpanah, Mehdi M.; Torrez, Neil; Alizadeh, Amirali; Askari, Davood

    2014-03-01

    This article reports on the development of tuning fork-based AFM/STM probes in NaugaNeedles LLC for use in atomic force microscopy. These probes can be mounted on different carriers per customers' request. (e.g., RHK carrier, Omicron carrier, and tuning fork on a Sapphire disk). We are able to design and engineer tuning forks on any type of carrier used in the market. We can attach three types of tips on the edge of a tuning fork prong (i.e., growing Ag2Ga nanoneedles at any arbitrary angle, cantilever of AFM tip, and tungsten wire) with lengths from 100-500 μm. The nanoneedle is located vertical to the fork. Using a suitable insulation and metallic coating, we can make QPlus sensors that can detect tunneling current during the AFM scan. To make Qplus sensors, the entire quartz fork will be coated with an insulating material, before attaching the nanoneedle. Then, the top edge of one prong is coated with a thin layer of conductive metal and the nanoneedle is attached to the fork end of the metal coated prong. The metal coating provides electrical connection to the tip for tunneling current readout and to the electrodes and used to read the QPlus current. Since the amount of mass added to the fork is minimal, the resonance frequency spectrum does not change and still remains around 32.6 KHz and the Q factor is around 1,200 in ambient condition. These probes can enhance the performance of tuning fork based atomic microscopy.

  4. Towards an autonomous self-tuning vibration energy harvesting device for wireless sensor network applications

    International Nuclear Information System (INIS)

    Challa, Vinod R; Prasad, M G; Fisher, Frank T

    2011-01-01

    Future deployment of wireless sensor networks will ultimately require a self-sustainable local power source for each sensor, and vibration energy harvesting is a promising approach for such applications. A requirement for efficient vibration energy harvesting is to match the device and source frequencies. While techniques to tune the resonance frequency of an energy harvesting device have recently been described, in many applications optimization of such systems will require the energy harvesting device to be able to autonomously tune its resonance frequency. In this work a vibration energy harvesting device with autonomous resonance frequency tunability utilizing a magnetic stiffness technique is presented. Here a piezoelectric cantilever beam array is employed with magnets attached to the free ends of cantilever beams to enable magnetic force resonance frequency tuning. The device is successfully tuned from − 27% to + 22% of its untuned resonance frequency while outputting a peak power of approximately 1 mW. Since the magnetic force tuning technique is semi-active, energy is only consumed during the tuning process. The developed prototype consumed maximum energies of 3.3 and 3.9 J to tune to the farthest source frequencies with respect to the untuned resonance frequency of the device. The time necessary for this prototype device to harvest the energy expended during its most energy-intensive (largest resonant frequency adjustment) tuning operation is 88 min in a low amplitude 0.1g vibration environment, which could be further optimized using higher efficiency piezoelectric materials and system components

  5. Part 5: Receiver Operating Characteristic Curve and Area under the Curve

    Directory of Open Access Journals (Sweden)

    Saeed Safari

    2016-04-01

    Full Text Available Multiple diagnostic tools are used by emergency physicians,every day. In addition, new tools are evaluated to obtainmore accurate methods and reduce time or cost of conventionalones. In the previous parts of this educationalseries, we described diagnostic performance characteristicsof diagnostic tests including sensitivity, specificity, positiveand negative predictive values, and likelihood ratios. Thereceiver operating characteristics (ROC curve is a graphicalpresentation of screening characteristics. ROC curve is usedto determine the best cutoff point and compare two or moretests or observers by measuring the area under the curve(AUC. In this part of our educational series, we explain ROCcurve and two methods to determine the best cutoff value.

  6. Modified Hyperspheres Algorithm to Trace Homotopy Curves of Nonlinear Circuits Composed by Piecewise Linear Modelled Devices

    Directory of Open Access Journals (Sweden)

    H. Vazquez-Leal

    2014-01-01

    Full Text Available We present a homotopy continuation method (HCM for finding multiple operating points of nonlinear circuits composed of devices modelled by using piecewise linear (PWL representations. We propose an adaptation of the modified spheres path tracking algorithm to trace the homotopy trajectories of PWL circuits. In order to assess the benefits of this proposal, four nonlinear circuits composed of piecewise linear modelled devices are analysed to determine their multiple operating points. The results show that HCM can find multiple solutions within a single homotopy trajectory. Furthermore, we take advantage of the fact that homotopy trajectories are PWL curves meant to replace the multidimensional interpolation and fine tuning stages of the path tracking algorithm with a simple and highly accurate procedure based on the parametric straight line equation.

  7. Frequency-Splitting-Free Synchronous Tuning of Close-Coupling Self-Oscillating Wireless Power Transfer

    Directory of Open Access Journals (Sweden)

    Po Hu

    2016-06-01

    Full Text Available The synchronous tuning of the self-oscillating wireless power transfer (WPT in a close-coupling condition is studied in this paper. The Hamel locus is applied to predict the self-oscillating points in the WPT system. In order to make the system operate stably at the most efficient point, which is the middle resonant point when there are middle resonant and split frequency points caused by frequency-splitting, the receiver (RX rather than the transmitter (TX current is chosen as the self-oscillating feedback variable. The automatic delay compensation is put forward to eliminate the influence of the intrinsic delay on frequency tuning for changeable parameters. In addition, the automatic circuit parameter tuning based on the phase difference is proposed to realize the synchronous tuning of frequency and circuit parameters. The experiments verified that the synchronous tuning proposed in this paper is effective, fully automatic, and more robust than the previous self-oscillating WPT system which use the TX current as the feedback variable.

  8. Signature Curves Statistics of DNA Supercoils

    OpenAIRE

    Shakiban, Cheri; Lloyd, Peter

    2004-01-01

    In this paper we describe the Euclidean signature curves for two dimensional closed curves in the plane and their generalization to closed space curves. The focus will be on discrete numerical methods for approximating such curves. Further we will apply these numerical methods to plot the signature curves related to three-dimensional simulated DNA supercoils. Our primary focus will be on statistical analysis of the data generated for the signature curves of the supercoils. We will try to esta...

  9. Method of construction spatial transition curve

    Directory of Open Access Journals (Sweden)

    S.V. Didanov

    2013-04-01

    Full Text Available Purpose. The movement of rail transport (speed rolling stock, traffic safety, etc. is largely dependent on the quality of the track. In this case, a special role is the transition curve, which ensures smooth insertion of the transition from linear to circular section of road. The article deals with modeling of spatial transition curve based on the parabolic distribution of the curvature and torsion. This is a continuation of research conducted by the authors regarding the spatial modeling of curved contours. Methodology. Construction of the spatial transition curve is numerical methods for solving nonlinear integral equations, where the initial data are taken coordinate the starting and ending points of the curve of the future, and the inclination of the tangent and the deviation of the curve from the tangent plane at these points. System solutions for the numerical method are the partial derivatives of the equations of the unknown parameters of the law of change of torsion and length of the transition curve. Findings. The parametric equations of the spatial transition curve are calculated by finding the unknown coefficients of the parabolic distribution of the curvature and torsion, as well as the spatial length of the transition curve. Originality. A method for constructing the spatial transition curve is devised, and based on this software geometric modeling spatial transition curves of railway track with specified deviations of the curve from the tangent plane. Practical value. The resulting curve can be applied in any sector of the economy, where it is necessary to ensure a smooth transition from linear to circular section of the curved space bypass. An example is the transition curve in the construction of the railway line, road, pipe, profile, flat section of the working blades of the turbine and compressor, the ship, plane, car, etc.

  10. Active tuning of surface phonon polariton resonances via carrier photoinjection

    Science.gov (United States)

    Dunkelberger, Adam D.; Ellis, Chase T.; Ratchford, Daniel C.; Giles, Alexander J.; Kim, Mijin; Kim, Chul Soo; Spann, Bryan T.; Vurgaftman, Igor; Tischler, Joseph G.; Long, James P.; Glembocki, Orest J.; Owrutsky, Jeffrey C.; Caldwell, Joshua D.

    2018-01-01

    Surface phonon polaritons (SPhPs) are attractive alternatives to infrared plasmonics for subdiffractional confinement of infrared light. Localized SPhP resonances in semiconductor nanoresonators are narrow, but that linewidth and the limited extent of the Reststrahlen band limit spectral coverage. To address this limitation, we report active tuning of SPhP resonances in InP and 4H-SiC by photoinjecting free carriers into nanoresonators, taking advantage of the coupling between the carrier plasma and optic phonons to blueshift SPhP resonances. We demonstrate state-of-the-art tuning figures of merit upon continuous-wave excitation (in InP) or pulsed excitation (in 4H-SiC). Lifetime effects cause the tuning to saturate in InP, and carrier redistribution leads to rapid (electronic and phononic excitations.

  11. Compensating amplitude-dependent tune-shift without driving fourth-order resonances

    Science.gov (United States)

    Ögren, J.; Ziemann, V.

    2017-10-01

    If octupoles are used in a ring to correct the amplitude-dependent tune-shift one normally tries to avoid that the octupoles drive additional resonances. Here we consider the optimum placement of octupoles that only affects the amplitude-dependent tune-shift, but does not drive fourth-order resonances. The simplest way turns out to place three equally powered octupoles with 60 ° phase advance between adjacent magnets. Using two such octupole triplets separated by a suitable phase advance cancels all fourth-order resonance driving terms and forms a double triplet we call a six-pack. Using three six-packs at places with different ratios of the beta functions allows to independently control all amplitude-dependent tune-shift terms without exciting additional fourth-order resonances in first order of the octupole excitation.

  12. On the Tuning and the Mass of the Composite Higgs

    CERN Document Server

    Panico, Giuliano; Tesi, Andrea; Wulzer, Andrea

    2013-01-01

    We analyze quantitatively the tuning of composite Higgs models with partial compositeness and its interplay with the predicted Higgs mass. In this respect we identify three classes of models, characterized by different quantum numbers of the fermionic colored resonances associated with the top quark, the so-called top partners. The main result of this classification is that in all models with moderate tuning a light Higgs, of 125 GeV mass, requires the presence of light top partners, around 1 TeV. The minimal tuning is comparable to the one of the most attractive supersymmetric models in particular the ones realizing Natural SUSY. This gives further support to an extensive program of top partners searches at the LHC that can already probe the natural region of composite Higgs models.

  13. Thermal tuning On narrow linewidth fiber laser

    Science.gov (United States)

    Han, Peiqi; Liu, Tianshan; Gao, Xincun; Ren, Shiwei

    2010-10-01

    At present, people have been dedicated to high-speed and large-capacity optical fiber communication system. Studies have been shown that optical wavelength division multiplexing (WDM) technology is an effective means of communication to increase the channel capacity. Tunable lasers have very important applications in high-speed, largecapacity optical communications, and distributed sensing, it can provide narrow linewidth and tunable laser for highspeed optical communication. As the erbium-doped fiber amplifier has a large gain bandwidth, the erbium-doped fiber laser can be achieved lasing wavelength tunable by adding a tunable filter components, so tunable filter device is the key components in tunable fiber laser.At present, fiber laser wavelength is tuned by PZT, if thermal wavelength tuning is combined with PZT, a broader range of wavelength tuning is appearance . Erbium-doped fiber laser is used in the experiments,the main research is the physical characteristics of fiber grating temperature-dependent relationship and the fiber grating laser wavelength effects. It is found that the fiber laser wavelength changes continuously with temperature, tracking several temperature points observed the self-heterodyne spectrum and found that the changes in spectra of the 3dB bandwidth of less than 1kHz, and therefore the fiber laser with election-mode fiber Bragg grating shows excellent spectral properties and wavelength stability.

  14. Photoelectic BV Light Curves of Algol and the Interpretations of the Light Curves

    Directory of Open Access Journals (Sweden)

    Ho-Il Kim

    1985-06-01

    Full Text Available Standardized B and V photoelectric light curves of Algol are made with the observations obtained during 1982-84 with the 40-cm and the 61-cm reflectors of Yonsei University Observatory. These light curves show asymmetry between ascending and descending shoulders. The ascending shoulder is 0.02 mag brighter than descending shoulder in V light curve and 0.03 mag in B light curve. These asymmetric light curves are interpreted as the result of inhomogeneous energy distribution on the surface of one star of the eclipsing pair rather than the result of gaseous stream flowing from KOIV to B8V star. The 180-year periodicity, so called great inequality, are most likely the result proposed by Kim et al. (1983 that the abrupt and discrete mass losses of cooler component may be the cause of this orbital change. The amount of mass loss deduced from these discrete period changes turned out to be of the order of 10^(-6 - 10^(-5 Msolar.

  15. Dreams, mnemonics, and tuning for criticality.

    Science.gov (United States)

    Pearlmutter, Barak A; Houghton, Conor J

    2013-12-01

    According to the tuning-for-criticality theory, the essential role of sleep is to protect the brain from super-critical behaviour. Here we argue that this protective role determines the content of dreams and any apparent relationship to the art of memory is secondary to this.

  16. A Journey Between Two Curves

    Directory of Open Access Journals (Sweden)

    Sergey A. Cherkis

    2007-03-01

    Full Text Available A typical solution of an integrable system is described in terms of a holomorphic curve and a line bundle over it. The curve provides the action variables while the time evolution is a linear flow on the curve's Jacobian. Even though the system of Nahm equations is closely related to the Hitchin system, the curves appearing in these two cases have very different nature. The former can be described in terms of some classical scattering problem while the latter provides a solution to some Seiberg-Witten gauge theory. This note identifies the setup in which one can formulate the question of relating the two curves.

  17. Qualification and preparatory activities for the manufacturing of 9 TF coils of the JT-60SA magnet

    International Nuclear Information System (INIS)

    Cucchiaro, Antonio; Polli, Gian Mario; Cocilovo, Valter; Drago, Giovanni; Cuneo, Stefano; Terzi, Franco; Peyrot, Marc; Phillips, Guy; Tomarchio, Valerio

    2013-01-01

    In the framework of the Broader Approach Agreement for the construction of the JT-60SA tokamak, ENEA is in charge to provide 9 of the 18 Toroidal Field (TF) coils. The 9 coils are being manufactured by ASG superconductors in Genoa under the supervision of ENEA in collaboration with the JT-60SA European home team. Prior the manufacturing, a preparatory activity has been carried out aimed at designing, constructing and setting-up the relevant components to be realized. In order to get confidence of some special manufacturing process, several qualification activities have been performed. In this paper an overview of the principal milestones reached during the preparatory phase and a description of the qualification activities with relevant test results are presented

  18. Bond yield curve construction

    Directory of Open Access Journals (Sweden)

    Kožul Nataša

    2014-01-01

    Full Text Available In the broadest sense, yield curve indicates the market's view of the evolution of interest rates over time. However, given that cost of borrowing it closely linked to creditworthiness (ability to repay, different yield curves will apply to different currencies, market sectors, or even individual issuers. As government borrowing is indicative of interest rate levels available to other market players in a particular country, and considering that bond issuance still remains the dominant form of sovereign debt, this paper describes yield curve construction using bonds. The relationship between zero-coupon yield, par yield and yield to maturity is given and their usage in determining curve discount factors is described. Their usage in deriving forward rates and pricing related derivative instruments is also discussed.

  19. Curve Digitizer – A software for multiple curves digitizing

    Directory of Open Access Journals (Sweden)

    Florentin ŞPERLEA

    2010-06-01

    Full Text Available The Curve Digitizer is software that extracts data from an image file representing a graphicand returns them as pairs of numbers which can then be used for further analysis and applications.Numbers can be read on a computer screen stored in files or copied on paper. The final result is adata set that can be used with other tools such as MSEXCEL. Curve Digitizer provides a useful toolfor any researcher or engineer interested in quantifying the data displayed graphically. The image filecan be obtained by scanning a document

  20. QCD Monte-Carlo model tuning studies with CMS data at 13 TeV

    CERN Document Server

    Sunar Cerci, Deniz

    2018-01-01

    New CMS PYTHIA 8 event tunes are presented. The new tunes are obtained using minimum bias and underlying event observables using Monte Carlo configurations with consistent parton distribution functions and strong coupling constant values in the matrix element and the parton shower. Validation and performance studies are presented by comparing the predictions of the new tune to various soft- and hard-QCD measurements at 7, 8 and 13 TeV with CMS.