Drawing disability in Japanese manga: visual politics, embodied masculinity, and wheelchair basketball in Inoue Takehiko's REAL.

Science.gov (United States)

Wood, Andrea

2013-12-01

This work explores disability in the cultural context of contemporary Japanese comics. In contrast to Western comics, Japanese manga have permeated the social fabric of Japan to the extent that vast numbers of people read manga on a daily basis. It has, in fact, become such a popular medium for visual communication that the Japanese government and education systems utilize manga as a social acculturation and teaching tool. This multibillion dollar industry is incredibly diverse, and one particularly popular genre is sports manga. However, Inoue Takehiko's award-winning manga series REAL departs from more conventional sports manga, which typically focus on able-bodied characters with sometimes exaggerated superhuman physical abilities, by adopting a more realistic approach to the world of wheelchair basketball and the people who play it. At the same time REAL explores cultural attitudes toward disability in Japanese culture-where disability is at times rendered "invisible" either through accessibility problems or lingering associations of disability and shame. It is therefore extremely significant that manga, a visual medium, is rendering disability visible-the ultimate movement from margin to center. REAL devotes considerable attention to realistically illustrating the lived experiences of its characters both on and off the court. Consequently, the series not only educates readers about wheelchair basketball but also provides compelling insight into Japanese cultural notions about masculinity, family, responsibility, and identity. The basketball players-at first marginalized by their disability-join together in the unity of a sport typically characterized by its "abledness."

Balão único versus balão de Inoue na valvoplastia mitral percutânea por balão. Resultados imediatos e complicações Single balloon versus Inoue balloon in percutaneous mitral balloon valvuloplasty. Short-term results and complications

Directory of Open Access Journals (Sweden)

Edison C. Sandoval Peixoto

1998-07-01

Full Text Available OBJETIVO: Avaliar os resultados imediatos e complicações da valvoplastia mitral percutânea por balão (VMPB, com o balão de Inoue (BI e com o balão único (BU. MÉTODOS: Dentre 390 procedimentos utilizaram-se o BI em 29 procedimentos e o BU de baixo perfil em 337. Não houve diferença na idade e sexo nos 2 grupos. O grupo BI era menos sintomático (p=0,0015. Não houve diferença na distribuição do escore ecocardiográfico e da área valvar mitral (AVM pré-VMPB. RESULTADOS: Quando compararam-se os 2 grupos entre si, os resultados nos grupos BI e BU foram, respectivamente: pré-VMPB para pressão pulmonar média (PPM 36±15 e 39±14mmHg, p=0,2033, para gradiente (GRAD mitral médio 17±6 e 20±7mmHg, p=0,0396 e AVM 0,9±0,2 e 0,9��9,2cm², p=0,8043, enquanto os valores pós-VMPB foram PPM 25±8 e 28±10mmHg, p=0,2881, GRAD 5±3 e 5±4mmHg, p=0,2778 e AVM 2,2±0,2 e 2,0±0,4cm², p=0,0362. Pré-VMPB a válvula mitral era competente em 26 procedimentos com o BI e 280 dos com o BU e havia regurgitação mitral de +/4 em 3 do grupo BI e em 57 do BU, p=0,3591 e pós-VMPB tivemos, no grupo BI a valva mitral (VM competente em 18, +/4 em 7 e 2+/4 em 4 e no grupo BU, a VM era competente em 218, +/4 em 80, 2+/4 em 25, 3+/4 em 5 e 4+/4 em 2, p=0,7439. Só houve complicações no grupo BU. CONCLUSÃO: As duas técnicas foram eficientes. Os resultados hemodinâmicos foram semelhantes, embora a AVM pós-VMPB do grupo do BI foi maior.PURPOSE: To assess short-term results and complications of percutaneous mitral balloon valvuloplasty (PMBV performed with Inoue balloon (IB and single low profile balloon (SB. METHODS: We performed 390 PMBV procedures, 29 with IB and 337 with SB . There were no differences in age, sex, echocardiographic score distribution and echocardiographic mitral valve area (MVA. RESULTS: We performed 29 complete procedures with IB and 330 of 337 in SB group. Comparing IB and pre and pos-PMBV data we obtained: mean pulmonary artery

Aplicações da tomografia de ressonância magnética nuclear como método não-destrutivo para avaliar os efeitos de injúrias mecânicas em goiabas 'Paluma' e 'Pedro Sato' Applications of the nuclear magnetic resonance tomography as a non-destructive method to evaluate the effects of mechanical injuries in 'Paluma' and 'Pedro Sato' guavas

Directory of Open Access Journals (Sweden)

Ben-Hur Mattiuz

2002-12-01

Full Text Available Objetivou-se determinar o potencial do uso da tomografia de ressonância magnética, como método não-destrutivo, para avaliar os efeitos das injúrias mecânicas em goiabas. Foram utilizados frutos no estádio de maturação "de vez" das cultivares Paluma e Pedro Sato. Na injúria por impacto, os frutos foram deixados cair, em queda livre, de uma altura de 1,20 m, sofrendo dois impactos, em lados opostos de sua porção equatorial. Na injúria por compressão, os frutos foram submetidos a um peso de 29,4 N, por 15 minutos. Para a injúria por corte, foram efetuados dois cortes, no sentido longitudinal dos frutos, de exatamente 30 mm de comprimento por 2 mm de profundidade. Os frutos injuriados foram armazenados sob condições de ambiente (22 ± 2 °C e 40 %UR. Foram realizadas análises com tomógrafo de ressonância magnética Varian Inova de 2 Tesla. As imagens foram obtidas a partir da detecção dos prótons de hidrogênio (¹H. Para cada fruto, foram obtidos tomogramas simétricos a partir do centro do fruto. A tomografia de ressonância magnética nuclear mostrou-se uma ferramenta eficaz na detecção de injúrias internas de frutos. O estresse físico causado pelo impacto produziu um colapso interno nos lóculos desses frutos (internal bruising, levando à perda da integridade celular e a conseqüente liquefação dos tecidos placentários. A cultivar Pedro Sato mostrou uma suscetibilidade maior à injúria por impacto que a 'Paluma'. A injúria por compressão tornou-se mais evidente no pericarpo externo do fruto, de ambas as cultivares. A injúria por corte levou a lignificação dos tecidos no local injuriado e deformações superficiais devido à perda acentuada de matéria fresca no local da lesão, evidentes no sexto dia de avaliação.The present study reports on the potential of the use of the tomography of magnetic resonance, as a non-destructive method, to evaluate the effects of the mechanical injuries in guava fruits

EFEITO DE INJÚRIAS MECÂNICAS NO PROCESSO RESPIRATÓRIO E NOS PARÂMETROS QUÍMICOS DE GOIABAS 'PALUMA' E 'PEDRO SATO'

Directory of Open Access Journals (Sweden)

MATTIUZ BEN-HUR

2001-01-01

Full Text Available O objetivo deste trabalho foi avaliar o efeito das injúrias mecânicas por impacto, compressão ou corte na atividade respiratória e na composição química de goiabas 'Paluma' e 'Pedro Sato' colhidas no estádio de maturação "de vez" e armazenadas a 23,4±1 °C e 62±6 % UR (condições de ambiente. Na injúria por impacto, os frutos foram deixados cair, por duas vezes e em queda livre, de uma altura de 1,20 m, sofrendo os impactos em lados opostos de sua porção equatorial. Na injúria por compressão, os frutos foram submetidos a um peso de 3 kg, por 15 minutos. Para a injúria por corte foram efetuados 2 cortes no sentido longitudinal dos frutos, de 30 mm de comprimento por 2 mm de profundidade. Os frutos injuriados foram colocados em bandejas de isopor e armazenados sob as condições de ambiente, com a atividade respiratória avaliada diariamente e seus conteúdos de sólidos solúveis totais, açúcares redutores, acidez total titulável e ácido ascórbico, determinados a cada 2 dias. Houve um incremento na evolução da atividade respiratória dos frutos em todos os tratamentos durante o armazenamento, com os injuriados produzindo maior quantidade de CO2 (184,12 mg de CO2.kg-1.h-1 que os do controle (164,23 mg de CO2.kg-1.h-1. Os frutos da 'Paluma' apresentaram essa atividade mais intensa (178,39 mg de CO2.kg-1.h-1 que os da 'Pedro Sato' (169,35 mg de CO2.kg-1.h-1, e não se detectou durante o período de armazenamento a ocorrência de pico respiratório. Os teores de sólidos solúveis totais (9,39 °Brix, açúcares redutores (2,24 g de glicose.100 g-1, acidez total titulável (706,25 mg de ácido cítrico.100 g-1 e ácido ascórbico (65,33 mg.100 g-1 dos frutos injuriados apresentaram-se com valores menores que os do controle, ao longo do período de armazenamento.

Transformações químicas, físicas e enzimáticas de goiabas 'PEDRO SATO' tratadas na pós-colheita com cloreto de cálcio e 1-metilciclopropeno e armazenadas sob refrigeração Chemical, physical and enzymatic transformations of guavas 'PEDRO SATO' treated at post-harvest with calcium chlorite and 1-methylciclopropone and stored under refrigeration

Directory of Open Access Journals (Sweden)

Lucilia Alves Linhares

2007-06-01

Full Text Available Com o objetivo de estudar o efeito dos tratamentos com cloreto de cálcio e com 1-MCP associando-se a refrigeração, na conservação e qualidade de goiabas 'Pedro Sato', conduziu-se o experimento em que frutos dessa cultivar foram tratados com solução de CaCl2 a 2% por 5 minutos e com 1-MCP na concentração de 150 nL/L por 12 horas em câmara hermeticamente fechada. Após os tratamentos, os frutos foram armazenados em câmara refrigerada a 10ºC e 90 ± 2% de umidade relativa, por um período de 25 dias. Os resultados indicaram que os tratamentos foram efetivos em manter a qualidade da fruta, salientando-se os frutos tratados com 1-MCP, que mantiveram uma melhor aparência interna e externa, apresentaram menor perda de massa, maior firmeza, menor síntese de vitamina C, menor solubilização de pectinas e menor atividade enzimática, aumentando desta forma a vida pós-colheita das goiabas.With the purpose of investigating the effect of the treatments with calcium chlorite and with 1-methylcyclopropene, associated with refrigeration, on the conservation and quality of guavas 'Pedro Sato', the experiment was carried out in which the fruit of thiscultivar was treated with a solution of 2% CaCl2 for 5 minutes and with 1-MCP at the concentration of 150 nL/L for 12 hours in a tightly sealed chamber. After the treatments, the fruit was stored in a refrigerated chamber at 10ºC and 90 ± 2% of relative humidity for a 25-days period. The results pointed out that the treatments were effective in maintaining fruit quality, stressing the 1-MCP-treated fruit, which kept a better internal and external appearance, presented less loss of mass, greater firmness, less synthesis of vitamin C, less pectin and less activity enzymatic activity, increasing in this way the post-harvest life of guavas.

Notes on the Plagiochilaceae, IX. A Review of the Genus Plagiochila (Dum.) Dum. (Hepaticae) in the Galapagos Islands

NARCIS (Netherlands)

Inoue, Hiroshi; Gradstein, S. Rob

1980-01-01

El género Plagiochila (hepatica) esta representada en las Islas Galapagos por ocho (8) especies diferentes: P. bursata (Desv.) Lindenbg., P. galapagona Inoue, P gradsteinii Inoue, P. guilleminiana Mont., P. inouei Grolle, P. scabrifolia Inoue, P. spinifera Ångstr. y P. subplana Lindenbg. El

On a class of reductions of the Manakov-Santini hierarchy connected with the interpolating system

International Nuclear Information System (INIS)

Bogdanov, L V

2010-01-01

Using the Lax-Sato formulation of the Manakov-Santini hierarchy, we introduce a class of reductions such that the zero-order reduction of this class corresponds to the dKP hierarchy, and the first-order reduction gives the hierarchy associated with the interpolating system introduced by Dunajski. We present the Lax-Sato form of a reduced hierarchy for the interpolating system and also for the reduction of arbitrary order. Similar to the dKP hierarchy, the Lax-Sato equations for L (the Lax function) split from the Lax-Sato equations for M (the Orlov function) due to the reduction, and the reduced hierarchy for an arbitrary order of reduction is defined by Lax-Sato equations for L only. A characterization of the class of reductions in terms of the dressing data is given. We also consider a waterbag reduction of the interpolating system hierarchy, which defines (1+1)-dimensional systems of hydrodynamic type.

Topical steroid addiction in atopic dermatitis

OpenAIRE

Fukaya, Mototsugu; Sato, Kenji; Sato, Mitsuko; Kimata, Hajime; Fujisawa, Shigeki; Dozono, Haruhiko; Yoshizawa, Jun; Minaguchi, Satoko

2014-01-01

Mototsugu Fukaya,1 Kenji Sato,2 Mitsuko Sato,3 Hajime Kimata,4 Shigeki Fujisawa,5 Haruhiko Dozono,6 Jun Yoshizawa,7 Satoko Minaguchi8 1Tsurumai Kouen Clinic, Nagoya, 2Department of Dermatology, Hannan Chuo Hospital, Osaka, 3Sato Pediatric Clinic, Osaka, 4Kimata Hajime Clinic, Osaka, 5Fujisawa Dermatology Clinic, Tokyo, 6Dozono Medical House, Kagoshima, 7Yoshizawa Dermatology Clinic, Yokohama, 8Department of Dermatology, Kounosu Kyousei Hospital, Saitama, Japan Abstract: The American Academy ...

Non-self-adjoint Hamiltonians defined by generalized Riesz bases

Energy Technology Data Exchange (ETDEWEB)

Inoue, H., E-mail: h-inoue@math.kyushu-u.ac.jp [Graduate School of Mathematics, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan); Takakura, M., E-mail: mayumi@fukuoka-u.ac.jp [Department of Applied Mathematics, Fukuoka University, Fukuoka 814-0180 (Japan)

2016-08-15

Bagarello, Inoue, and Trapani [J. Math. Phys. 55, 033501 (2014)] investigated some operators defined by the Riesz bases. These operators connect with quasi-Hermitian quantum mechanics, and its relatives. In this paper, we introduce a notion of generalized Riesz bases which is a generalization of Riesz bases and investigate some operators defined by the generalized Riesz bases by changing the frameworks of the operators defined in the work of Bagarello, Inoue, and Trapani.

Sato Processes in Default Modeling

DEFF Research Database (Denmark)

Kokholm, Thomas; Nicolato, Elisa

In reduced form default models, the instantaneous default intensity is classically the modeling object. Survival probabilities are then given by the Laplace transform of the cumulative hazard defined as the integrated intensity process. Instead, recent literature has shown a tendency towards...

Sato Processes in Default Modeling

DEFF Research Database (Denmark)

Kokholm, Thomas; Nicolato, Elisa

2010-01-01

In reduced form default models, the instantaneous default intensity is the classical modeling object. Survival probabilities are then given by the Laplace transform of the cumulative hazard defined as the integrated intensity process. Instead, recent literature tends to specify the cumulative haz...

Metric solution of a spinning mass

International Nuclear Information System (INIS)

Sato, H.

1982-01-01

Studies on a particular class of asymptotically flat and stationary metric solutions called the Kerr-Tomimatsu-Sato class are reviewed about its derivation and properties. For a further study, an almost complete list of the papers worked on the Tomimatsu-Sato metrics is given. (Auth.)

Influence of impulsivity-reflexivity when testing dynamic spatial ability: sex and g differences.

Science.gov (United States)

Quiroga, M Angeles; Hernández, José Manuel; Rubio, Victor; Shih, Pei Chun; Santacreu, José

2007-11-01

This work analyzes the possibility that the differences in the performance of men and women in dynamic spatial tasks such as the Spatial Orientation Dynamic Test-Revised (SODT-R; Santacreu & Rubio, 1998), obtained in previous works, are due to cognitive style (Reflexivity-Impulsivity) or to the speed-accuracy tradeoff (SATO) that the participants implement. If these differences are due to cognitive style, they would be independent of intelligence, whereas if they are due to SATO, they may be associated with intelligence. In this work, 1652 participants, 984 men and 668 women, ages between 18 and 55 years, were assessed. In addition to the SODT-R, the "Test de Razonamiento Analitico, Secuencial e Inductivo" (TRASI [Analytical, Sequential, and Inductive Reasoning Test]; Rubio & Santacreu, 2003) was administered as a measure of general intelligence. Impulsivity scores (Zi) of Salkind and Wright (1977) were used to analyze reflexivity-impulsivity and SATO. The results obtained indicate that (a) four performance groups can be identified: Fast-accurate, Slow-inaccurate, Impulsive, and Reflexive. The first two groups solve the task as a function of a competence variable and the last two as a function of a personality variable; (b) performance differences should be attributed to SATO; (c) SATO differs depending on sex and intelligence level.

Ukiyo-e Adamson-Ericus

Index Scriptorium Estoniae

2003-01-01

Näitus "300 aastat jaapani puulõike traditsiooni. Ukiyo-e puulõiked meister Keizo Sato töökojast". Esitletakse faksiimiletõmmiseid Hokusai, Hiroshige, Utamaru, Sharaku jt. kunstnike töödest. Näituse koostasid Keizo Sato (sünd. 1940) ja Tuula Moilanen. 14.-16. VII Jaapani-teemaline kunstilaager 8-12aastastele lastele

Ripening pattern of guava cv. Pedro Sato Padrão de amadurecimento de goiaba cv. Pedro Sato

Directory of Open Access Journals (Sweden)

José Renato de Abreu

2012-06-01

Full Text Available Guava is a fruit with high respiration rates and a very short shelf life. Since information on its respiration pattern is contradictory, the objective was to study the changes occurring in the fruit during ripening and to relate them to the respiration behavior of this fruit. Guavas were picked at the half-ripe stage and stored for 8 days at 22 ± 1 ºC and 78 ± 1% relative humidity. The analyses conducted were: peel and pulp coloration, firmness, total soluble solids (TSS, total titratable acidity (TTA, and ethylene production. According to the results, it was verified that the parameters analyzed apparently do not coincide and are ethylene-independent. There was an accentuated ethylene production during ripening, starting from the 4th day. The ethylene synthesis continued increasing up to the 8th day, when the fruits were already decomposing. It was observed that the firmness decreased sharply in the first three days of ripening, and the skin and pulp color changed during ripening. The TSS, total soluble solids, and the TTA, total titratable acidity, practically did not change during the ripening, even with the increased ethylene production. It can be concluded that guava is a fruit that presents characteristics of climacteric and non-climacteric fruits.A goiaba apresenta altas taxas de respiração e uma vida útil muito curta, e como as informações sobre o padrão respiratório são contraditórias, objetivou-se estudar mudanças ocorridas no fruto durante o amadurecimento e relacioná-las ao comportamento respiratório desses frutos. Foram colhidas goiabas no estádio "de vez" e armazenadas por 8 dias à temperatura ambiente (22 ± 1 ºC e umidade relativa de 78 ± 1%. As análises realizadas foram: coloração da casca e polpa, firmeza, sólidos solúveis totais (SST, acidez total titulável (ATT e produção de etileno. Pelos resultados, verificou-se que todas as variáveis analisadas aparentemente não coincidem e independem da síntese de etileno. A produção de etileno durante o amadurecimento teve aumento acentuado a partir do 4º dia. Até o 8º dia, com os frutos já em fase de decomposição, a síntese do etileno continuava aumentando. Observou-se que a firmeza diminuiu acentuadamente nos três primeiros dias de amadurecimento e a cor da casca e da polpa alteraram com o amadurecimento. Os SST e a ATT dos frutos praticamente não variaram durante o amadurecimento, mesmo com o aumento da produção de etileno. Conclui-se que a goiaba é um fruto que apresenta características de frutos climatéricos e também de frutos não climatéricos.

Second International Conference on Snow Engineering.

Science.gov (United States)

1992-12-01

for Scientific Research on Priority Areas 1991(03201137), Representative: Mikio Sasaki, Hachinohe Institute of Technology]. REFERENCES Sato T. and N...Technology Prof. Mikio Sasaki USACRREL 35-1 Kasumicho Yagiyama Hachinohe Inst. of Technology 72 Lyme Road Taihakuku, Sendai 982 Japan Department of Civil...Ebara Co. Ltd, Sato Engineering Co. Ltd., Maruiso Construction Co. Ltd. and Argos Co. Ltd. Also they have been supported by a Grant-in-Aid of

ONR (Office of Naval Research) Far East Scientific Bulletin. Volume 10, Number 1, January to March 1985.

Science.gov (United States)

1985-03-01

Katsuhiko Sakaue and Mikio Takagi at ETL for the separation of particles, in complex pictures of overlapping K units. The algorithm uses both parallel...Director Itaru TODORIKI Deputy Director Kohei SATO ? Research Planning Office Fundamental Science Division Computer Science Division Energy Division...attendance. Until last year it had been held on the Komaba campus of the University of Tokyo, with Professor Hiroshi Sato as the chief organizer and

The Shock and Vibration Digest. Volume 18, Number 12

Science.gov (United States)

1986-12-01

Sfstem Subjected to Random Excitation K. Sato , S. Yamamoto, O. Kamada, N. Takatsu Utsuncmiya Univ., Utsunomiya, Japan Bull. JSME, 22 (251), pp... Sato Tokyo Institute of Technology, Yokohama, Japan Bull. JSME, IS! (251), pp 1605-1611 (May 1986) 15 figs, 2 tables, 18 refs KEY WORDS...Matiunaga, T Mattuahita, Mikio Matiuuchi, Kazuo Matteucci, M Matyiiak, S.J Matzen, V.C May, R.A Mayct , M.J Maye» , R.L 1340, Maye», W.H

Japan’s Search for Strategic Vision: The Contemporary Debate

Science.gov (United States)

1993-02-25

American relations break down: "they want to go with the winning horse," as he put it.59 Similarly, Mr. Mikio Haruna, deputy editor on the foreign desk...76 The unusually harsh words bore the stamp of the study’s principal author, noted Tokyo University political scientist Seizaburo Sato . On another...occasion, Sato told an interviewer that there have always been ups and downs in the image of the United States in Japan. But there is a growing concern

Japanese Studies on Manchuria. Volume 11. Part 3. Book C. Small Wars and Border Problems, The Nomonhan Incident

Science.gov (United States)

1956-11-05

toward our left flank area: Right wing: 72d Inf Regt (00, Col. Mikio Sakai), under Maj. Gen. Kobayashi Left wing; Three bna, 7th Div, under toaj...appeared bewildered. A« When UaJ. Gen. Kotoku Sato , the former commander of the 2d Sector Unit, 8th BGD, arrived from Hailar to replace the critically...34ounded Gen. Kobayashi, he was impressed by the "atmosphere of death" prevailing at 23d Division Headquarters. Sato Interview, Tokyo, 3 Jul 56

Jaapani graafika Tallinnas

Index Scriptorium Estoniae

2003-01-01

Ku galeriis jaapani kaasaegse graafika näitus "Living Faces in Tallinn". Kouichi Kitamura kujundatud väljapanek tutvustab rühmituse Printsaurus kunstnike töid. Adamson-Ericu muuseumis näitus "300 aastat Jaapani puulõike traditsiooni. Ukiyo-e puulõiked meister Keizo Sato töökojast". 12. ja 13 IX esinevad näitusel Keizo Sato, tema assistent Makoto Nakayama, puulõikemeister Hiroshi Fujizawa ja ukiyo-e uurija kunstnik Tuula Moilanen. 12. IX loengud "Ukiyo-e puulõike maailm", 13. IX esitletakse ukiyo-e puulõiketehnikat

Stemcell Information: SKIP001151 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available ayu Yamazaki-Inoue,Takumi Miura,Mohan C. Vemuri,Mahendra S. Rao,Kenji Miyado,Akihiro Umezawa Regenerative Therapy 2015 1 June 18-29 http://dx.doi.org/10.1016/j.reth.2014.12.004 ...

A reagentless amperometric immunosensor based on nano-au and ...

African Journals Online (AJOL)

Jane

2011-08-01

Aug 1, 2011 ... which was then mixed with AU nanoparticles (nano-Au) and multi-walled carbon nanotubes (MWCNTs) ..... Kaminishi D, Ozaki H, Ohno Y, Maehashi K, Inoue K, Matsumoto K, Seri ... nanoparticle doped chitosan film. Anal.

Interpersonal sensitivity mediates the effects of child abuse and affective temperaments on depressive symptoms in the general adult population

Directory of Open Access Journals (Sweden)

Otsuka A

2017-10-01

Full Text Available Ayano Otsuka,1 Yoshikazu Takaesu,1 Mitsuhiko Sato,1 Jiro Masuya,1 Masahiko Ichiki,1 Ichiro Kusumi,2 Takeshi Inoue1 1Department of Psychiatry, Tokyo Medical University, Tokyo, 2Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan Background: Recent studies have suggested that multiple factors interact with the onset and prognosis of major depressive disorders. In this study, we investigated how child abuse, affective temperaments, and interpersonal sensitivity are interrelated, and how they affect depressive symptoms in the general adult population. Subjects and methods: A total of 415 volunteers from the general adult population completed the Patient Health Questionnaire-9, the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire version, the Child Abuse and Trauma Scale, and the Interpersonal Sensitivity Measure, which are all self-administered questionnaires. Data were subjected to structural equation modeling (Mplus, and single and multiple regression analyses. Results: The effect of child abuse on depressive symptoms was mediated by interpersonal sensitivity and 4 affective temperaments, including depressive, cyclothymic, anxious, and irritable temperaments. In addition, the effect of these temperaments on depressive symptoms was mediated by interpersonal sensitivity, indicating the indirect enhancement of depressive symptoms. In contrast to these 4 temperaments, the hyperthymic temperament did not mediate the effect of child abuse on depressive symptoms; its effect was not mediated by interpersonal sensitivity. However, a greater hyperthymic temperament predicted decreased depressive symptoms and interpersonal sensitivity, independent of any mediation effect. Limitations: Because this is a cross-sectional study, long-term prospective studies are necessary to confirm its findings. Therefore, recall bias should be considered when interpreting the results. As the subjects were

Palatal rugae as a tool for human identification

African Journals Online (AJOL)

2014-03-10

Mar 10, 2014 ... conducted to assess the accuracy of rugoscopy as a tool for ... assessment than dental interns (P = 0.001; confidence ... dentist following mass disaster. ... Utsuno H, Kanoh T, Tadokoro O, Inoue K. Preliminary study of post‑ ...

Irreducible mass for the Tomimatsu-Sato space-time

Energy Technology Data Exchange (ETDEWEB)

Calvani, M [Padua Univ. (Italy). Ist. di Astronomia; Salmistraro, F; Catenacci, R

1979-01-01

A global definition of irreducible mass for the odd delta T-S metrics is investigated. It is found that its expression in terms of the source parameters is the same for all the members of the family and reduces to the formula that holds in the Kerr case (delta = 1). As a consequence, it is shown that processes with msub(ir) = const no longer imply zero variations of the horizon's area for delta > 1.

Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implications in Fracture Repair and Wound Healing in Humans

Science.gov (United States)

2006-04-01

used for future diagnosis of patients who are susceptible to osteoporosis. Furthermore, the identity of candidate gene could lead to future...growth hormone gene causes semidominant dwarfism , hyperghrelinemia, and obesity. Endocrinology 145(5):2531-41. 8. Inoue M, Sakuraba Y, Motegi H, Kubota

Stemcell Information: SKIP000355 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available rius Aquarius ... 20-29 Female ... -- No PL-iPS-11|PAE551-derived iPS cells PAE551由来iPS細胞 human ES-li...amics in human induced pluripotent stem cells over time. Nishino K, Toyoda M, Yamazaki-Inoue M, Fukawatase Y

Fixed point of the parabolic renormalization operator

CERN Document Server

Lanford III, Oscar E

2014-01-01

This monograph grew out of the authors' efforts to provide a natural geometric description for the class of maps invariant under parabolic renormalization and for the Inou-Shishikura fixed point itself as well as to carry out a computer-assisted study of the parabolic renormalization operator. It introduces a renormalization-invariant class of analytic maps with a maximal domain of analyticity and rigid covering properties and presents a numerical scheme for computing parabolic renormalization of a germ, which is used to compute the Inou-Shishikura renormalization fixed point.   Inside, readers will find a detailed introduction into the theory of parabolic bifurcation,  Fatou coordinates, Écalle-Voronin conjugacy invariants of parabolic germs, and the definition and basic properties of parabolic renormalization.   The systematic view of parabolic renormalization developed in the book and the numerical approach to its study will be interesting to both experts in the field as well as graduate students wishi...

Homogeneity of common cosmopolitan inversion frequencies in ...

Indian Academy of Sciences (India)

Unknown

notypic variation have so far not been conducted. We performed a chromosomal analysis using five natural population samples from Thailand, Malaysia, and the ..... mass cultures over time in D. melanogaster populations, and may even be eliminated altogether (Inoue 1979;. Singh and Das 1992b). However, this effect was ...

Singularities in the delta = 3 Tomimatsu-Sato space-time

Energy Technology Data Exchange (ETDEWEB)

Calvani, M [Padua Univ. (Italy). Ist. di Astronomia; Turolla, R [International School for Advanced Studies, Trieste (Italy)

1980-08-02

The existence of singularities outside the equatorial plane is investigated. We show that when the specific angular momentum a exceeds the mass m of the source, there are six ring singularities, while when a

Trans-Catheter Therapy of Lutembacher Syndrome: A Case Report

Directory of Open Access Journals (Sweden)

Hossein Nough

2011-05-01

Full Text Available Lutembacher syndrome refers to the rare combination of a congenital atrial septal defect and acquired mitral stenosis. Traditionally, Lutembacher syndrome has been corrected by surgical treatment. We describe two patients treated percutaneouly with a combined Inoue balloon valvuloplasty and septal defect closure using the Amplatzer septal occlusion device.

Japanese Ground Forces Order of Battle Bulletins (7 April - 2 June 1945) Part 1

Science.gov (United States)

1945-01-01

Narumi (49) ISHII Mas’ayoshi (121) . ( ISHII Shiro (99) ISHIKAWA Megumu (—). 10/41 8/59 INAMURA Toyojiro (60) 12/40 INOUE Fumio (100) 8/48 8/41...MGHITA Ncrimasa (~) ,• MORXTAMA Tokuaitsu (131) MQTOlzttel Kaoru {116) MOTOYOSHI* KeisiSr6iilbb)3 a’ MUKAI Xinjiro (95)-^\\s) :- HURAJI Toshio 144

Personalized Medicine in Veterans with Traumatic Brain Injuries

Science.gov (United States)

2014-07-01

Inoue K, Ishii J, et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science 2007;317:1220–4. 9. Elder GA, Cristian A. Blast-related mild...alternative splicing of the serotonin 2c receptor [38], and that patients with autism and Prader-Willi-like characteristics are found to have reduced

井上靖文学における「川」

OpenAIRE

趙, 秀娟; Tyo, Shuken,

2014-01-01

In Yasushi Inoue's literary works, rivers always appears as representative images. It has rich symbolic meanings, through which the author expressed his outlook on life and the development of history. The rivers are symbols of infinity and eternal nature, through the contrast between the infinity of river and the finity of human beings.

ISSN 2073 ISSN 2073-9990 East Cent. Afr. J. surg. (Online) 9990 ...

African Journals Online (AJOL)

DELL

Bolger WE, Butzin CA, Parsons DS. Paranasal sinus bony anatomic variations and mucosal abnormalities: CT analysis for endoscopic sinus surgery. Laryngoscope 1991; 101(1 Pt 1):. 56-64. 23. Wang J, Bidari S, Inoue K, Yang H, Rhoton A Jr. Extensions of the sphenoid sinus: a new classification. Neurosurgery 2010; 66: ...

8 CFR 286.4 - Fee collection responsibility.

Science.gov (United States)

2010-01-01

..., travel agents, tour wholesalers, or other parties, which issue tickets or documents for transportation on... Agents Handbook, the SATO Ticketing Handbook, or compatible procedures set forth in the operations manual...

Outcomes of microincision vitrectomy surgery with internal limiting membrane peeling for macular edema secondary to branch retinal vein occlusion

Directory of Open Access Journals (Sweden)

Sato S

2015-03-01

Full Text Available Shimpei Sato,1 Maiko Inoue,2 Shin Yamane,2 Akira Arakawa,2 Mikiro Mori,1 Kazuaki Kadonosono2 1Department of Opthalmology, Toranomon Hospital, Tokyo, Japan; 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan Purpose: To evaluate the anatomic and functional effect of microincision vitrectomy surgery (MIVS with internal limiting membrane (ILM peeling for macular edema secondary to branch retinal vein occlusion (BRVO.Methods: The medical records of 101 eyes of 101 patients who had undergone MIVS with ILM peeling for macular edema secondary to BRVO were studied. Patients were classified into ischemic and non-ischemic BRVO based on angiograph. The best-corrected visual acuity (BCVA and central foveal thickness (CFT, determined by spectral domain optical coherence tomography, were evaluated at baseline and at 1, 3, 6, and 12 months postoperatively.Results: Preoperative mean logarithm of the minimum angle of resolution (logMAR BCVA ± standard deviation (SD was 0.52±0.43 and mean CFT ± SD was 489.4±224.9 µm. Postoperative mean BCVA ± SD values were 0.41±0.35, 0.35±0.41, 0.29±0.36, and 0.25±0.41, and mean CFT values were 370.1±148.9, 327.5±157.5, 310.9±154.9, and 274.4±135.3 µm at 1, 3, 6, 12 months, respectively. The mean BCVA was significantly improved at 3, 6, and 12 months postoperatively (all P<0.05, and the mean CFT was significantly decreased at all postoperative follow-up time points (all P<0.05. At the 12-month postoperative evaluation, BCVA had improved by 0.2 logMAR units in 50 eyes (60.0% with ischemic BRVO and in nine eyes (50.0% with non-ischemic BRVO. Six eyes (6.0% experienced recurrence or persistence of macular edema at 12 months postoperatively.Conclusion: MIVS with ILM peeling for macular edema secondary to BRVO is effective in improving visual acuity and foveal morphology with low recurrence of macular edema. Keywords: MIVS, ILM, BRVO, central foveal thickness, CFT

Topical steroid addiction in atopic dermatitis

Directory of Open Access Journals (Sweden)

Fukaya M

2014-10-01

Full Text Available Mototsugu Fukaya,1 Kenji Sato,2 Mitsuko Sato,3 Hajime Kimata,4 Shigeki Fujisawa,5 Haruhiko Dozono,6 Jun Yoshizawa,7 Satoko Minaguchi8 1Tsurumai Kouen Clinic, Nagoya, 2Department of Dermatology, Hannan Chuo Hospital, Osaka, 3Sato Pediatric Clinic, Osaka, 4Kimata Hajime Clinic, Osaka, 5Fujisawa Dermatology Clinic, Tokyo, 6Dozono Medical House, Kagoshima, 7Yoshizawa Dermatology Clinic, Yokohama, 8Department of Dermatology, Kounosu Kyousei Hospital, Saitama, Japan Abstract: The American Academy of Dermatology published a new guideline regarding topical therapy in atopic dermatitis in May 2014. Although topical steroid addiction or red burning skin syndrome had been mentioned as possible side effects of topical steroids in a 2006 review article in the Journal of the American Academy of Dermatology, no statement was made regarding this illness in the new guidelines. This suggests that there are still controversies regarding this illness. Here, we describe the clinical features of topical steroid addiction or red burning skin syndrome, based on the treatment of many cases of the illness. Because there have been few articles in the medical literature regarding this illness, the description in this article will be of some benefit to better understand the illness and to spur discussion regarding topical steroid addiction or red burning skin syndrome. Keywords: topical steroid addiction, atopic dermatitis, red burning skin syndrome, rebound, corticosteroid, eczema

Main: 1WEW [RPSD[Archive

Lifescience Database Archive (English)

Full Text Available 60420. Name=At5g60420; Arabidopsis Thaliana Molecule: Dna-Binding Family Protein; Chain: A; Fragment: Phd Domai...F.He, Y.Muto, M.Inoue, T.Kigawa, M.Shirouzu, T.Terada, S.Yokoyama Solution Structure Of Phd Domai...n In Dna-Binding Family Protein Aam98074 To Be Published Nmr, Structural Genomics, Phd Domai

Dissecting the Molecular Mechanism of RhoC GTPase Expression in the Normal and Malignant Breast

Science.gov (United States)

2010-09-01

validated via qRT-PCR (Fig. S6) and FISH (Fig. 3D ). Interestingly, this fusion has previously been reported in an independent sample found by a...Ohta, H. Inoue, M.G. Cotticelli, K. Kastury, R. Baffa, J. Palazzo, Z. Siprashvili, M. Mori, P. McCue, T. Druck , C.M. Croce, K. Huebner, The FHIT gene

Emerging Donors Study | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

20 oct. 2010 ... The four country studies were coordinated and authored by: Alcides: Costa Vaz and Cristina Yumie Aoki Inoue, University of Brazilia China: Gregory T. Chin ... Lorsque les liens communautaires mènent aux crimes violents. Exploration de la cohésion sociale et de la méfiance envers l'État à titre de facteurs ...

Úplatek v obchodě

OpenAIRE

Koudelka Zdeněk

2013-01-01

Úplatky v obchodních vztazích jsou na okraji zájmu boje proti korupci, kdy se většinou věnuje pozornost veřejnému sektoru. Nejde však o věc novou. The article Bribe in Commerce desribes bribe in private sector in the Czech Republic.

Stemcell Information: SKIP000859 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available Progenitors Ameliorates Acute Kidney Injury in Mice.--Cell Therapy Using Human Induced Pluripotent Stem Cel...l-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice. Okita K, Yamakawa T, Matsumura Y, Sato

Resting Serum Concentration of High-Sensitivity C-Reactive Protein ...

African Journals Online (AJOL)

olayemitoyin

stress which may be more prevalent in sportsmen has also been shown to initiate an increase in ..... Sato, K. (1999) 'Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage', J Appl ...

Stemcell Information: SKIP000860 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available l Progenitors Ameliorates Acute Kidney Injury in Mice.--Cell Therapy Using Human Induced Pluripotent Stem Ce...ll-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice. Okita K, Yamakawa T, Matsumura Y, Sato

Reversible and irreversible transformations in the Tomimatsu-Sato space-times

Energy Technology Data Exchange (ETDEWEB)

Calvani, M [Padua Univ. (Italy). Ist. di Astronomia; Catenacci, R; Salmistraro, F [Pavia Univ. (Italy)

1978-10-14

The transformations which leave constant the area of the horizons are taken into account; it is show that for delta>1 they do not coincide with reversible transformations. The concepts of irreducible mass and unincreasable angular momentum are extended to the odd members of the T-S family.

Effects of U.S. Navy Diver Training on Physiological Parameters, Time of Useful Consciousness and Cognitive Performance During Periods of Normobaric Hypoxia

Science.gov (United States)

2014-04-01

TRAINING ON PHYSIOLOGICAL PARAMETERS, TIME OF USEFULL CONSCIOUSNESS, AND COGNITIVE PERFORMANCE DURING PERIODS OF NORMOBARIC HYPOXIA...Sato, Y. Watanabe, "Time of Usefull Consciousness Determination in Aircrew Members with Rerference to Prior Altitude Chamber Experience and Age

Geometric Structure of the Classical Lagrange-d’Alambert Principle and Its Application to Integrable Nonlinear Dynamical Systems

Directory of Open Access Journals (Sweden)

Anatolij K. Prykarpatski

2017-12-01

Full Text Available The classical Lagrange-d’Alembert principle had a decisive influence on formation of modern analytical mechanics which culminated in modern Hamilton and Poisson mechanics. Being mainly interested in the geometric interpretation of this principle, we devoted our review to its deep relationships to modern Lie-algebraic aspects of the integrability theory of nonlinear heavenly type dynamical systems and its so called Lax-Sato counterpart. We have also analyzed old and recent investigations of the classical M. A. Buhl problem of describing compatible linear vector field equations, its general M.G. Pfeiffer and modern Lax-Sato type special solutions. Especially we analyzed the related Lie-algebraic structures and integrability properties of a very interesting class of nonlinear dynamical systems called the dispersionless heavenly type equations, which were initiated by Plebański and later analyzed in a series of articles. As effective tools the AKS-algebraic and related R -structure schemes are used to study the orbits of the corresponding co-adjoint actions, which are intimately related to the classical Lie-Poisson structures on them. It is demonstrated that their compatibility condition coincides with the corresponding heavenly type equations under consideration. It is also shown that all these equations originate in this way and can be represented as a Lax-Sato compatibility condition for specially constructed loop vector fields on the torus. Typical examples of such heavenly type equations, demonstrating in detail their integrability via the scheme devised herein, are presented.

ONR (Office of Naval Research) Far East Scientific Bulletin. Volume 9, Number 4, October-December 1984,

Science.gov (United States)

1984-12-01

Faculty of Engineering Science Toyonaka, Osaka 560 . Professor Susumu Namba Associate Professor Kenji Gamo Dr. Mikio Takai Research Activities...hydrographic measurements. K. Sato , M. Ooe, International Latitude Observatory of Mizusawa, and T. Teramoto, University of Tokyo, Japan, provided ye

Security of quantum key distribution with a laser reference coherent state, resistant to loss in the communication channel

International Nuclear Information System (INIS)

Molotkov, S N; Potapova, T A

2015-01-01

The problem of quantum key distribution security in channels with large losses is still open. Quasi-single-photon sources of quantum states with losses in the quantum communication channel open up the possibility of attacking with unambiguous state discrimination (USD) measurements, resulting in a loss of privacy. In this letter, the problem is solved by counting the classic reference pulses. Conservation of the number of counts of intense coherent pulses makes it impossible to conduct USD measurements. Moreover, the losses in the communication channel are considered to be unknown in advance and are subject to change throughout the series parcels. Unlike other protocols, differential phase shift (Inoue et al 2002 Phys. Rev. Lett. 89 037902, Inoue et al 2003 Phys. Rev. A 68 022317, Takesue et al 2007 Nat. Photon. 1 343, Wen et al 2009 Phys. Rev. Lett. 103 170503) and coherent one way (Stucki et al 2005 Appl. Phys. Lett. 87 194108, Branciard et al 2005 Appl. Phys. Lett. 87 194108, Branciard et al 2008 New J. Phys. 10 013031, Stucki et al 2008 Opt. Express 17 13326), the simplicity of the protocol makes it possible to carry out a complete analysis of its security. (letter)

Non-isospectral flows of noncommutative differential-difference KP equation

International Nuclear Information System (INIS)

Huang, Lin; Ilangovane, R.; Tamizhmani, K.M.; Zhang, Da-jun

2013-01-01

We present master symmetries of noncommutative differential-difference KP equation by considering Sato approach, where the field variables are defined over associative algebras. The Lie algebraic structures of generalized and master symmetries are given. They form a Virasoro Lie algebraic structure

chronic dehydration affects hydroelectrolytic equilibrium and adrenal

African Journals Online (AJOL)

A. Dekar-Madoui

2017-05-01

May 1, 2017 ... response but rather an index of metabolic strategy probably for metabolic ... [11] Dai WJ, Yao T. Effects of dehydration and salt-loading on ... [12] Kondo N, Arima H, Banno R, Kuwahara S, Sato I, Oiso Y. Osmoregulation of.

Dynamic Modeling of Natural Convection Solar Energy Collector

African Journals Online (AJOL)

NIJOTECH

ovens, and low temperature and industrial process heat generation systems. ..... Benedict, R.P. fundamental of Temperature. ... Sato, M. Electrochemical Measurements and Control of Oxygen fugacity and other ... Wilson, R.E., Temperature, in Condine, M. and Ross, S. D., (Eds.), Handbook of Applied Instrumentation.

NGS Reveals Molecular Pathways Affected by Obesity and Weight Loss-Related Changes in miRNA Levels in Adipose Tissue

Directory of Open Access Journals (Sweden)

Alina Kuryłowicz

2017-12-01

Full Text Available Both obesity and weight loss may cause molecular changes in adipose tissue. This study aimed to characterize changes in adipose tissue miRNome in order to identify molecular pathways affected by obesity and weight changes. Next generation sequencing (NGS was applied to identify microRNAs (miRNAs differentially expressed in 47 samples of visceral (VAT and subcutaneous (SAT adipose tissues from normal-weight (N, obese (O and obese after surgery-induced weight loss (PO individuals. Subsequently miRNA expression was validated by real-time PCR in 197 adipose tissues and bioinformatics analysis performed to identify molecular pathways affected by obesity-related changes in miRNA expression. NGS identified 344 miRNAs expressed in adipose tissues with ≥5 reads per million. Using >2 and <−2 fold change as cut-offs we showed that the expression of 54 miRNAs differed significantly between VAT-O and SAT-O. Equally, between SAT-O and SAT-N, the expression of 20 miRNAs differed significantly, between SAT-PO and SAT-N the expression of 79 miRNAs differed significantly, and between SAT-PO and SAT-O, the expression of 61 miRNAs differed significantly. Ontological analyses disclosed several molecular pathways regulated by these miRNAs in adipose tissue. NGS-based miRNome analysis characterized changes of the miRNA profile of adipose tissue, which are associated with changes of weight possibly responsible for a differential regulation of molecular pathways in adipose tissue when the individual is obese and after the individual has lost weight.

On the ILW hierarchy

International Nuclear Information System (INIS)

Tutiya, Y.; Satsuma, J.

2003-01-01

In this Letter, we present a new hierarchy which includes the intermediate long wave (ILW) equation at the lowest order. This hierarchy is thought to be a novel reduction of the 1st modified KP type hierarchy. The framework of our investigation is Sato theory

Understanding metal–insulator transition in sodium tungsten bronze

Indian Academy of Sciences (India)

, A Chakraborty, D D Sarma, P Mahadevan, S. Oishi, W H McCarroll and M Greenblatt, Phys. Rev. B 75, 155116 (2007). [17] S Raj, A Chakraborty, D Choudhury, T Sato, T Takahashi, P Mahadevan, J Fujii, I Vobornik and D D Sarma, Phys. Rev.

Primary biliary cirrhosis and scleroderma complicated by Barrett's ...

African Journals Online (AJOL)

1991-04-06

Apr 6, 1991 ... primary biliary cirrhosis, CREST syndrome, and chronic pancreatitis. Thorax. 1983; 38: 316-317. 9. Okano Y, Nisbikai M, Sato A. Scleroderma, primary biliary cirrhosis, and. Sjogren's syndrome after cosmetic breast augmentation with silicone injec- tion: a case reporfof possible human adjuvant disease.

Altered gene-expression profile in rat plasma and promoted body ...

African Journals Online (AJOL)

jane

RT-PCR validation. Six genes (Irf7 ... filtered to validate with RT-PCR according to the set, the .... Fold change .... activate ERK, but not of Ras, after B cell receptor cross- .... Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada.

Fiber Optic Chemical Sensors

Science.gov (United States)

1993-10-01

31, 1980. Koyama, Masao and Sato , Yuichi, "Improved Enzyme Sensor for Glucose with an Ultra-Filtration Membrane and Immobilized Glucose Oxidase...ion Process," American Laboratory, AVO, AIS, 54-59, 1989. Kaihara, Mikio ; Mametsuka, Hiroaki; Gunji, Naoki; Iwata, Hideo and Gohshi,, "New Dilution

Afrique : ressources minières, environnement et gouvernance ...

International Development Research Centre (IDRC) Digital Library (Canada)

25 janv. 2011 ... ils regorgent de richesses inouïes », assure Bonnie Campbell, directrice du Groupe de recherche sur les activités minières en Afrique (GRAMA) et titulaire de la Chaire C.-A. Poissant de recherche sur la gouvernance et l'aide au développement, faisant référence aux ressources minières et pétrolières dont ...

Current Status of Peroral Endoscopic Myotomy

OpenAIRE

Cho, Young Kwan; Kim, Seong Hwan

2018-01-01

Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic ...

Twenty-Fifth Annual Conference on the Physics and Chemistry of Semiconductor Interfaces. Volume 16, Number 4

Science.gov (United States)

1998-08-01

atomic level structure and Fermi level pinning on GaAs(110) surfaces grown by molecular beam epitaxy Yasuhiko Ishikawa, Naohiro Tsurumi, Takashi Fukui...molecular beam epitaxy Yasuhiko lshikawa,a) Naohiro Tsurumi, Takashi Fukui, and Hideki Hasegawa Research Center for Interface Quantum Electronics and...Inoue, K.-(2) 895 Iriguchi, T.-(2) 790 Isakozawa, S.-(4) 2532 Ishikawa, J.-(2) 829, 833, 895 Ishikawa, Junzo-(4) 2515 Ishikawa, Yasuhiko -(4) 2387

Organization of Workshop on Emerging Technologies for In-Situ Processing

Science.gov (United States)

1992-08-31

scale Structures Kengi Gamo Low Energy Fused Ion Beam System and In Situ Processing Mikio Takai Nanofabrication Using STM Tip (Discussion: Melngailis...Jon Orloff & Mitsugu Sato 1 Oregon Graduate Institute 19600 von Neumann Drive Beaverton, OR 97006, USA A high resolution focused ion beam (FIB) is an

Perbedaan Kelas Sosial sebagai Penyebab Ijime dalam Novel Grotesque

Directory of Open Access Journals (Sweden)

Linda Unsriana

2012-10-01

Full Text Available Ijime or bullying is a common problem in Japanese schools, and even, ijime actions sometimes result in the victims or the victims commit to suicide. Ijime is also depicted in the Grotesqe novel on a character, Kazue Sato. Kazue Sato is a girl who desperately wants to enroll an elite girl school, Q school. The school is for students from high social class. Nevertheless, by passing the strict exams, intelligent students from different social classes can go to this school. Article  elaborates the relationship between social class differences in the actions of ijime, using a corpus of works Natsuo Kirino’s novel, Grotesque. After analyzing the data with descriptive method of analysis, it is found that there is a relationship between social class differences and ijime actions. Students from different social classes, although they are cleverer, cannot mingle with students from higher social classes. In fact, students from lower social classes experience ijime actions from other students.  

Effective potential for equatorial motion in the Tomimatsu-Sato space-times

Energy Technology Data Exchange (ETDEWEB)

Calvani, M [Padua Univ. (Italy). Ist. di Astronomia

1978-01-28

We give general rules to draw the effective potential curves for equatorial motion in the T-S space-times either with am. Some general properties of the potentials are pointed out and few examples shown.

Quantum Bio-Informatics II From Quantum Information to Bio-Informatics

Science.gov (United States)

Accardi, L.; Freudenberg, Wolfgang; Ohya, Masanori

2009-02-01

The problem of quantum-like representation in economy cognitive science, and genetics / L. Accardi, A. Khrennikov and M. Ohya -- Chaotic behavior observed in linea dynamics / M. Asano, T. Yamamoto and Y. Togawa -- Complete m-level quantum teleportation based on Kossakowski-Ohya scheme / M. Asano, M. Ohya and Y. Tanaka -- Towards quantum cybernetics: optimal feedback control in quantum bio informatics / V. P. Belavkin -- Quantum entanglement and circulant states / D. Chruściński -- The compound Fock space and its application in brain models / K. -H. Fichtner and W. Freudenberg -- Characterisation of beam splitters / L. Fichtner and M. Gäbler -- Application of entropic chaos degree to a combined quantum baker's map / K. Inoue, M. Ohya and I. V. Volovich -- On quantum algorithm for multiple alignment of amino acid sequences / S. Iriyama and M. Ohya --Quantum-like models for decision making in psychology and cognitive science / A. Khrennikov -- On completely positive non-Markovian evolution of a d-level system / A. Kossakowski and R. Rebolledo -- Measures of entanglement - a Hilbert space approach / W. A. Majewski -- Some characterizations of PPT states and their relation / T. Matsuoka -- On the dynamics of entanglement and characterization ofentangling properties of quantum evolutions / M. Michalski -- Perspective from micro-macro duality - towards non-perturbative renormalization scheme / I. Ojima -- A simple symmetric algorithm using a likeness with Introns behavior in RNA sequences / M. Regoli -- Some aspects of quadratic generalized white noise functionals / Si Si and T. Hida -- Analysis of several social mobility data using measure of departure from symmetry / K. Tahata ... [et al.] -- Time in physics and life science / I. V. Volovich -- Note on entropies in quantum processes / N. Watanabe -- Basics of molecular simulation and its application to biomolecules / T. Ando and I. Yamato -- Theory of proton-induced superionic conduction in hydrogen-bonded systems

Numerical simulation of the dynamic flow behaviour in a bubble column: comparison of the bubble-induced turbulence models in K-epsilon model

NARCIS (Netherlands)

Zhang, D.; Deen, N.G.; Kuipers, J.A.M.

2005-01-01

Numerical simulations of the gas-liquid bubbly flow in a bubble column were conducted with the commercial CFD package CFX-4.4 to investigate the performance of three models (Pfleger and Becker, 2001; Sato and Sekoguchi, 1975; Troshko and Hassan, 2001) to account for the bubble-induced turbulence in

Koreans in Japan: Their Influence on Korean-Japanese Relations.

Science.gov (United States)

1979-09-01

1963. 31. The Republic of Korea National Red Cross, The Dispersed Families in Korea, Seoul, 1977. 32. Sato , Shoki, Koreans in Japan - The...1975. 34. Sumiya, Mikio , Kankoku no Keizai (The Korean Economy), Iwanami Shoten, Tokyo, Japan, 1974. 35. U.S. Government Printing Office, U.S. Army Area

Surfacing Authentic Leadership: Inspiration from "After Life"

Science.gov (United States)

Billsberry, Jon; North-Samardzic, Andrea

2016-01-01

This paper advocates an innovative approach to help leadership students analyze, capture, and remember the nature of their authentic leadership. This developmental activity was inspired by the Japanese film, "Wandâfuru raifu" ("After Life") (Kore-Eda, Sato, & Shigenobu, 1998), in which the recently deceased are asked to…

International Free Electron Laser Conference (15th) Held in The Hague, Netherland on August 23-27, 1993. Book of Abstracts

Science.gov (United States)

1993-08-27

missioning and service for: nology, extending from research and development, design, c( nstruction and El Synchrotron radiation facilities...Experiment Using the Coherent Synchrotron Radiation Emitted From Electron Bunches M. AsaKawa, N. Sakamoto, N. Inoue, T. Yamamoto, K. Mima, S. Nakai, J...Netherlands 12:30 Lunch Session Poster I 14:00 Th3-01 Magnetic Bunching Experiments on ELSA S. Joly, D.H. Dowell, ELSA -FEL Team CEN/SPTN, France Th3-03

Drydocking Facilities Characteristics. Design Manual 29.3.

Science.gov (United States)

1981-11-01

BEAM -7’ I07 PRECAST COLUMN j! ’~ FULLY RELIEVED ’ 6 EeDGE OF...SUBMARINE LONGITUDINAL SECTION (VIEW LOOKING WEST) 715𔄀" TO INNER FACE OF CAISSON INOUE SA CRANE TRACKS- PLAN VIEW COPING EL +20.0- 3’ 42’ BEAM ..f... connections west side. Chilled water ..... 6" supply and return mains, 600 gpm at 65 psi, one 6" supply and one 6" return connections west side. Low

Underachievement in Gifted Students: A Case Study of Three College Physics Students in Taiwan

Science.gov (United States)

Tsai, Kuei-Fang; Fu, Guopeng

2016-01-01

This case study provides an explanatory account on the underachievement of three gifted students studying physics in a Taiwanese university. The students' physics underachievement was diagnosed by Sato's student-problem analysis chart. These students were invited to complete a questionnaire and a follow-up interview in order to (1) understand the…

Increasing Compatibility Between Educational Practices and the Educational Needs of Pupils Who are Asian With Emphasis on Their Language and Cultural Needs.

Science.gov (United States)

Castillo, Lydia R.; Ponce, Corazon A.

The contents of this document are organized in eight parts, as follows. Part One, "Speech of Dr. Esther M. T. Sato," the consultant, Associate Professor at the College of Education, University of Hawaii, discusses the following topics: in the background of Filipinos in Hawaii, their social problems, Filipino cultural values, guidelines…

An Appetite for Creative Destruction: Should the Role of Senior Academic Technology Officer Be Modeled on a CIO or a CTO?

Science.gov (United States)

Shurville, Simon; Browne, Tom; Whitaker, Marian

2010-01-01

Purpose: This paper seeks to examine the emerging role of the Senior Academic Technology Officer (SATO) in higher education. It aims to consider two existing templates for this professional role derived from mainstream information management and information technology: the Chief Information Officer (CIO) and the Chief Technology Officer (CTO).…

Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress

OpenAIRE

Akiyoshi, Jotaro; Tsuru,Jusen; Tanaka,Yoshihiro; Ishitobi,Yoshinobu; Maruyama,Yoshihiro; Inoue,Ayako; Kawano,Aimi; Ikeda,Rie; Ando,Tomoko; Oshita,Harumi; Aizawa,Saeko; Masuda,Koji; Higuma,Haruka; Kanehisa,Masayuki; Ninomiya,Taiga

2014-01-01

Jusen Tsuru,1 Yoshihiro Tanaka,1 Yoshinobu Ishitobi,1 Yoshihiro Maruyama,1 Ayako Inoue,1 Aimi Kawano,1 Rie Ikeda,1 Tomoko Ando,1 Harumi Oshita,2 Saeko Aizawa,1 Koji Masuda,1 Haruka Higuma,1 Masayuki Kanehisa,1 Taiga Ninomiya,1 Jotaro Akiyoshi1 1Department of Neuropsychiatry, 2Department of Applied Linguistics, Faculty of Medicine, Oita University, Oita, Japan Background: Decreased expression of brain-derived neurotrophic factor (BDNF) is implicated in enhanced stress responses. The BDNF Val...

The association between suicide risk and self-esteem in Japanese university students with major depressive episodes of major depressive disorder

OpenAIRE

Mitsui, Nobuyuki; Asakura,Satoshi; Shimizu,Yusuke; Fujii,Yutaka; Toyomaki,Atsuhito; Kako,Yuki; Tanaka,Teruaki; Kitagawa,Nobuki; Inoue,Takeshi; Kusumi,Ichiro

2014-01-01

Nobuyuki Mitsui,1 Satoshi Asakura,1,2 Yusuke Shimizu,1 Yutaka Fujii,1 Atsuhito Toyomaki,1 Yuki Kako,1 Teruaki Tanaka,1 Nobuki Kitagawa,3 Takeshi Inoue,1 Ichiro Kusumi1 1Department of Psychiatry, Hokkaido University Graduate School of Medicine, 2Health care center of Hokkaido University, Kita-ku, Sapporo, 3Department of Clinical Social Work, Health Sciences University of Hokkaido School of Nursing and Social Services, Tobetsu, Ishikari, Japan Background: The suicide risk among young adults is...

The Battle for Leyte Gulf. October 1944. Strategical and Tactical Analysis. Volume II. Operations from 0719 October 17th until October 20th (D- Day)

Science.gov (United States)

1955-01-01

DESDIV’s 41, 61 Rear Admiral Kimura , Susumu CL YA{AGI (F) Captain Yoshimura, Matake DESDIV 4 Captain Takahashi, Kameshiro DD’s MICHISHIO (F),** NOWAKI...Captain Miura, Hayao DESRON 1 Rear Admiral Kimura , Masatomi CL ABUKUMA (FF) Captain Hanada, Takuo DESDIV 7 Commander Iwagami, Jiichi DD’s AKEBONO (F...USHIO DESDIV 18 Captain Inoue, Yoshio DD’s KASUMI, SHIRANUHI (F) DESDIV 21 Commander I~hii, Hisashi DD’s WAKABA (F), HATSUSHIMO, HATSUHARU CRUDIV -76

A new subgenus of Heterotrigona from New Guinea (Hymenoptera: Apidae)

DEFF Research Database (Denmark)

Engel, Michael S.; Rasmussen, Claus

2017-01-01

A new subgenus is established within the Indomalayan stingless bee genus Heterotrigona Schwarz (Meliponini). Sahulotrigona Engel & Rasmussen, new subgenus, is distinguished from amongst other Heterotrigona, particularly the subgenus Platytrigona Moure, within which one of the two included species...... in the following new combinations: Heterotrigona (Platytrigona) flaviventris (Friese), H. (P.) hobbyi (Schwarz), H. (P.) keyensis (Friese), H. (P.) lamingtonia (Cockerell), H. (P.) planifrons (Smith), H. (Sundatrigona) lieftincki (Sakagami & Inoue), and H. (Su.) moorei (Schwarz). The stingless bees of Papuasia...

Proceedings of the Seventh Joint Magnetism and Magnetic Materials-Intermag Conference 6-9 January 1998 San Francisco, California Volume 83, Number 11, Part 2.

Science.gov (United States)

1998-06-01

Takayuki Ichihara, Shigeki Nakagawa C. Ouyang, T. W. Kim, R. J. Gambino, C. Jahnes G. Suran, E. Boumaiz R. Jansen, J. S. Moodera J. F. Bobo, F. B...4A. Makino, T. Hatanai, A. Inoue, and T. Masumoto, Mater. Sei. Eng., A 226-228, 594 (1997). 5Y. Yoshizawa, S. Oguma, A. Hiraki and K. Yamauchi...nanocrystalline Fe-Cu-Nb-Si-B alloy by facing targets sputtering Masahiko Naoe, Hiroaki Matsumiya, Takayuki Ichihara, and Shigeki Nakagawa

Universal moduli space and string theory

International Nuclear Information System (INIS)

Schwarz, A.S.

1989-09-01

The construction of the universal supermoduli space is given. The super-Mumford form (the holomorphic square root from the string measure) is extended to the universal supermoduli space and expressed through the superanalog of Sato's τ-function. The hidden N=2 superconformal symmetry in the string theory is considered. (author). 13 refs

Entropy as a new measure of mechanical pain sensitivity in the masseter muscle

DEFF Research Database (Denmark)

Castrillon, Eduardo; Sato, Hitoshi; Tanosoto, Tomohiro

ENTROPY AS A NEW MEASURE OF MECHANICAL PAIN SENSITIVITY IN THE MASSETER MUSCLE Author Block: E. E. Castrillon1, H. Sato2,3, T. Tanosoto4, T. Arima4, L. Baad-Hansen1, P. Svensson1, 1Clinical Oral Physiology, Århus Univ., Aarhus, Denmark, 2Dept. of Dentistry & Oral Physiology, Sch. of Med., Keio Un...... injections (Pmechanical pain sensitivity that captures new aspects of spatial characteristics and could therefore complement more classical assessments of TMD pain patients.......ENTROPY AS A NEW MEASURE OF MECHANICAL PAIN SENSITIVITY IN THE MASSETER MUSCLE Author Block: E. E. Castrillon1, H. Sato2,3, T. Tanosoto4, T. Arima4, L. Baad-Hansen1, P. Svensson1, 1Clinical Oral Physiology, Århus Univ., Aarhus, Denmark, 2Dept. of Dentistry & Oral Physiology, Sch. of Med., Keio Univ......., Tokyo, Japan, 3Japan Society for the Promotion of Sci., Tokyo, Japan, 4Dept. of Oral Rehabilitation, Graduate Sch. of Dental Med., Hokkaido Univ., Sapporo, Japan : Aim of Investigation: Manual palpation is a psychophysical technique to evaluate mechanical pain sensitivity in craniofacial muscles...

The Battle for Leyte Gulf. October 1944. Strategical and Tactical Analysis. Volume III. Operations from 0000 October 20th (D-day) until 1042 October 23rd

Science.gov (United States)

1957-01-01

Kimura ,, Suasiw M YAHIAGI Captain loshlimura, Matake DD’ea "(AVI, KIYOSHIMO WMSIV 17 Captain Tanli, Tamotsu DD’sa URA&AZE (F), HAMAKAZZ, TUKIKAZE...FFF) Captain Kanooka, Empei CA ASHIGARA Captai, Miura, Hayeo DESRON 1 Rear Admiral Kimura , Masatomi CL ABIL1MA (FF) Captain Hanada, Takuo DESDIV 7...Commander Iwagami, Jiichi DD’s AKEBONO (F), USHIO DESDIV 18 Captain Inoue, Yoshio DD’s KASUMI, SHIRANUiI (F) DESDIV 21 Commander Ishii, Hisashi DD’s

Deterioration of Synthetic Fiber Rope during Marine Usage. Appendix A.

Science.gov (United States)

1981-12-31

Vliolet 7ra44ateci Nvlon 66, J. App1. Polvrn. Sc:. 9, 16311-1639 R112 K c*- =s*- 4, A., Ohtani, N. and Sato , T., Phenomenological S _ cf Viscoelastic Crack...2 *, 411-415 (1970). R445 Yano, Shoichiro and Murayara, Mikio , Effect of Photo- degradation on Dynamic Mechanical Properties of Nylon 6, J. Appl

JPRS Report, Science & Technology, Japan, Powder Metallurgy Technology

Science.gov (United States)

1988-12-13

Katsuhiro Imada and Ken Sato , Materials Research Laboratory, Mitsubishi Electric Corp.; and Yasuyuki Kawagoe and Kenichiro Yamanishi, Applied...Tomomi Ishigaki and Osamu Yamamoto, Faculty of Technology, Mie University; and Mikio Takano, Hiromasa Mazaki, Zenji Hiroi and Toshichika Bando...Liberal Arts, Kyoto University; and Yasunori Ikeda, Mikio Takano and Yoshichika Bando, Institute of Chemical Research, Kyoto University

Supergrassmannians, super τ-functions and strings

International Nuclear Information System (INIS)

Dolgikh, S.N.; Schwarz, A.S.

1989-03-01

Recently, infinite-dimensional grassmannians and their supergeneralizations were used to study conformal two-dimensional fields and strings. In particular, the super Mumford form (holomorphic square root from the superstring measure on moduli space) was expressed through super analog of Sato τ-function. In this paper we present results of supergrassmannians and super τ-functions. 8 refs

Structure of high-Tc superconducting tetragonal Ba2YCu2.856Al0.04O6.76 at 298 and 120 K

International Nuclear Information System (INIS)

Sato, S.

1989-01-01

It was found by chemical analysis that a slight amount of aluminium existed as an impurity in the crystals of the Y-Ba-Cu-O system whose structure was determined by Sato, Nakada, Kohara and Oda. Occupancies of atoms in 1(a) [the Cu(1) site] were 0.856(5) Cu, 0.04 Al and 0.104 vacancy. (orig.)

East African Medical Journal - Vol 79, No 2 (2002)

African Journals Online (AJOL)

Obesity and lipid profiles in middle aged men and women in Tanzania · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. M. A. Njelekela, H. Negishi, Y. Nara, T. Sato, M. Tomohiro, S. Kuga, T. Noguchi, T. Kanda, M. Yamori, Y. Matshalla, L. Jian Liu, K. Ikeda, J. Mtabaji, ...

Getting older can be exhausting.

Science.gov (United States)

Mittal, Rohit; Ford, Mandy L; Coopersmith, Craig M

2014-07-29

Sepsis is a disease that affects primarily the aged. Although mortality is higher in both older septic patients and aged septic mice, the mechanisms underlying decreased survival in older hosts are incompletely understood. New work by Inoue and colleagues demonstrates persistent inflammation and T-cell exhaustion in older septic patients and aged septic mice. The clinical significance of these findings is manifested not only in increased mortality but also in a marked difference in secondary infections in older patients as long as a month following ICU admission.

Comprehensive and Critical Literature Review on Insitu Micro-Sensors for Application in Tribology

Science.gov (United States)

1994-04-01

Tsugai, Masahiro; Bessho, Mikio ; Araki, Toru; Onishi, Masayoshi; Sesekura, Takashi Source: SAE Technical Paper Series. Publ by SAE, Warrendale, PA, USA...MONITORING OF HYDROGEN ASSISTED CRACKING OF LOW ALLOY STEEL. Author. Hayashi, Yasuhisa; Takemoto, Mikio Source: Boshoku Gijutsu/Corrosion Engineering v...METALS AND ITS APPLICATION TO AE SENSOR. Author. Shimizu, Hiroshi; Watanabe, Hiroshi; Sato , Michio Source:. Japanese Journal of Applied Physics, Supplement

Japanese Studies on Manchuria. Volume 11. Part 3. Book B. Small Wars and Border Problems, The Nomonhan Incident

Science.gov (United States)

1956-09-05

ranks and posts as of the time of the Nomonhan Incident): UaJ. Gen. Yuzaburo Hata, CG, 3d Heavy Field Artillery Brigade MaJ. Gen. Kotoku Sato , CG...111.. 1 II ^72 Col Mikio Sakoi I {X 23 Lt Col Yoozo Azumo _L [j Co 11. . 1 23 Tokahide Ise I I II 23 Isamu Saito fHBCSüJ

Industrial excellence is rewarded by CMS : as part of the sixth annual ceremony to honour its top suppliers, the CMS collaboration presented awards to nine firms

CERN Multimedia

maximilien brice

2005-01-01

Photo 31 : the representatives of the firms that received the CMS best supplier awards displaying their awards on 5 April. From left to right: C. Fulvia (Plyform), K. Sato and K. Yamamura (Hamamatsu Photonics), G. Roveta (Criotec Impianti), M. Fornari (Telema), H. P. Reinhardt (Reinhardt Microtech), M. Sonninen (Planar Systems), E. Dyakov (Lutch), M. Mottier (NGK Instulators) and J. Vital (Chipidea Microelectronics).

Sugar fractionation and pectin content during the ripening of guava cv. Pedro Sato Fracionamento de açúcares e teor de pectina durante o amadurecimento de goiaba cv. Pedro Sato

Directory of Open Access Journals (Sweden)

José Renato de Abreu

2012-03-01

Full Text Available Guava is one of the most complete and balanced fruits in in terms of s nutritional value. Highly perishable, due to its intense metabolism during ripening, its shelf life can reach 3 to 5 days under room temperature. The firmness of the green and mature fruits is due mainly to the pectin polymers. The loss of firmness during the guava ripening is due to hydrolytic enzyme activity, which promotes intense solubilization of the cell wall pectins. Given the above, with the purpose of trying to explain the rapid firmness decrease, the centesimal composition and sugar fraction of the guava fruit were determined during ripening at room temperature. The guavas were picked at the half-mature stage and stored for 8 days at 22 ± 1 ºC and 78 ± 1% relative humidity. The analyses conducted were: centesimal composition, sugar fractionation, and infrared absorption spectrometry. The results showed that the guava sugars did not vary during ripening. The estimated pectin levels (5.7% were higher than those mentioned in the literature (2.4%, which can better explain the role of the pectin in the fruit firmness.A goiaba é uma das mais completas e equilibradas frutas no que diz respeito ao valor nutritivo. Altamente perecível, devido ao seu intenso metabolismo durante o amadurecimento, tem vida útil que pode chegar de 3 até 5 dias sob temperatura ambiente. A firmeza dos frutos verdes e maduros é devida principalmente aos polímeros de pectina. A perda de firmeza durante o amadurecimento da goiaba é devido à atividade de enzimas hidrolíticas, que promovem intensa solubilização das pectinas constituintes da parede celular. Diante do exposto, com a finalidade de tentar explicar a rápida diminuição da firmeza, determinou-se a composição centesimal dos frutos da goiaba e fez-se um fracionamento dos açúcares durante o amadurecimento em temperatura ambiente. Foram colhidas goiabas no estádio "de vez" e armazenadas por 8 dias à temperatura de 22 ± 1 ºC e umidade relativa de 78 ± 1%. As análises realizadas foram: composição centesimal, fracionamento dos açúcares e espectrometria de absorção na região do infravermelho. Pelos resultados, verificou-se que os açúcares de goiaba não variaram durante o amadurecimento. Os teores de pectina estimados (5,7% foram maiores que os teores citados na literatura (2,4%, o que pode explicar melhor o papel da pectina na firmeza do fruto.

Venous hemogasometry of equines finalists in 90 km endurance races

Directory of Open Access Journals (Sweden)

Cinthia B.S. Dumont

2014-06-01

Full Text Available Front of exercise, the organic systems may suffer water-electrolyte and acid-base imbalances, particularly in the case of blood gases, demonstrating variations from different causes, whether respiratory and/or metabolic. Understanding the physiological adaptations to exercise is essential in the search for the optimum performance. In this way, this study measured the venous blood gases (pO2, pCO2, as well as the oxygen saturation (SatO2 in healthy equines, Arabian horses finalists in 90km endurance races. A total of fourteen Arabian horses were evaluated, nine males and five females, between six and 12 years old, finalists in 90km endurance races. There was a significant reduction in pO2, pCO2 and SatO2 after the exercise, however, the values remained within the normality range, and did not change the athletic performance of the animals, indicating a temporary alteration, assuming thus a character of physiological response to the exercise performed. The equines, finalists in 90 Km endurance races, demonstrated efficient ventilatory process, without any alterations in the athletic performance, being adapted to the type of exercise imposed.

Determinants of oxygen and carbon dioxide transfer during extracorporeal membrane oxygenation in an experimental model of multiple organ dysfunction syndrome.

Science.gov (United States)

Park, Marcelo; Costa, Eduardo Leite Vieira; Maciel, Alexandre Toledo; Silva, Débora Prudêncio E; Friedrich, Natalia; Barbosa, Edzangela Vasconcelos Santos; Hirota, Adriana Sayuri; Schettino, Guilherme; Azevedo, Luciano Cesar Pontes

2013-01-01

Extracorporeal membrane oxygenation (ECMO) has gained renewed interest in the treatment of respiratory failure since the advent of the modern polymethylpentene membranes. Limited information exists, however, on the performance of these membranes in terms of gas transfers during multiple organ failure (MOF). We investigated determinants of oxygen and carbon dioxide transfer as well as biochemical alterations after the circulation of blood through the circuit in a pig model under ECMO support before and after induction of MOF. A predefined sequence of blood and sweep flows was tested before and after the induction of MOF with fecal peritonitis and saline lavage lung injury. In the multivariate analysis, oxygen transfer had a positive association with blood flow (slope = 66, Pmembrane PaCO(2) (slope = -0.96, P = 0.001) and SatO(2) (slope = -1.7, Ptransfer had a positive association with blood flow (slope = 17, Pmembrane PaCO(2) (slope = 1.2, Ptransfers were significantly determined by blood flow. Oxygen transfer was modulated by the pre-membrane SatO(2) and CO(2), while carbon dioxide transfer was affected by the gas flow, pre-membrane CO(2) and hemoglobin.

Optimization of culture media for lipid production by Nannochloropsis oculata for Biodiesel production

Directory of Open Access Journals (Sweden)

Mohammad Malakootian

2015-09-01

Full Text Available Background: This study quantified the effect of four popular culture media in a biodiesel production study on the qualitative and quantitative lipid content, dry biomass, and lipid productivity of Nannochloropsis oculata. Methods: Culture of microalgae was done separately in Walne, F/2, Sato, and TMRL media. In the logarithmic and stationary growth phases, biomass production and lipid accumulation of microalgae were measured and the constituents were identified by gas chromatography. Results: N. oculata exhibited the highest rate of cell growth and biomass productivity of 0.2616 day-1 and 2.652 gl-1 in the Walne medium. The highest level of biomass conversion into lipids in TMRL medium revealed a cell dry weight of 37.22%. Walne medium proved to have the most efficient lipid productivity which was 0.1057 gl-1 day-1. The highest amount of triacylglycerol (TAG was obtained in Sato medium in the stationary growth phase and was 75.25% of the fatty acids. Conclusion: The present study provides a practical benchmark, which allows the introduction of Walne as a suitable culture medium for N. oculata in biodiesel studies.

Composition of the essential oil from the leaves of tree domestic varieties and one wild variety of the guava plant (Psidium guajava L., Myrtaceae

Directory of Open Access Journals (Sweden)

Rafaela Karin de Lima

Full Text Available The compositions of the essential oils from the leaves of three domestic varieties of the guava tree Psidium guajava L. (Paluma, Século XXI and Pedro Sato and of one wild variety were compared. Essential oils were extracted by steam distillation, the components were identified by gas chromatography coupled to mass spectrometry GC-MS, and the apparent concentrations were determined by gas chromatography with a flame ionization detector. The results demonstrated that the three essential oils contained many common substances with a prevalence of 1,8-cineole, whereas the essential oil of the Paluma variety contained 1,8-cineole (42.68% as the major constituent, as well as α-terpineol (38.68%. The principal components of the essential oil of the Século XXI variety were 1,8-cineole (18.83%, trans-caryophyllene (12.08%, and selin-11-en-4-αol (20.98%, while those of the Pedro Sato variety and of the wild plant were 1,8-cineole (17.68% and (12.83%, caryophyllene oxide (9.34% and (9.09%, and selin-11-en-4-α-ol (21.46% and (22.19%, respectively.

Evaluation of masticatory function after maxillectomy using a colour-changing chewing gum.

Science.gov (United States)

Shibuya, Y; Ishida, S; Kobayashi, M; Hasegawa, T; Nibu, K; Komori, T

2013-03-01

The purpose of this study was to identify the risk factors associated with the masticatory dysfunction after maxillectomy using a colour-changing chewing gum. Thirty-nine patients who underwent maxillectomy between January 2002 and May 2010 in the Department of Kobe University Hospital were recruited for this study. There were 20 male and 19 female subjects, with a median age of 73·3 years (range of 44-90) at the time of surgery. The intra-oral conditions after maxillectomy were classified by HS classification, and the masticatory function was evaluated by a colour-changing chewing gum and the results of a modified Sato's questionnaire. The scores of the colour-changing gum were closely correlated with the scores of the modified Sato's questionnaire (r = 0·661, P gum test masticatory dysfunction were the number of anchor teeth ≤2 and a soft palate defect. A colour-changing gum was found to be useful for evaluating the post-operative masticatory function, and it was important to conserve the anchor teeth and the soft palate to avoid masticatory dysfunction. © 2012 Blackwell Publishing Ltd.

Multilayered elastic analysis formulation for surface moment loading

CSIR Research Space (South Africa)

Maina, JW

2006-01-01

Full Text Available Denki University Hatoyama-Cho, Hiki-Gun, Saitama 350-0394, JAPAN Tel.: +81-492-96-2911 Fax: +81-492-96-6501 fkiyo@g.dendai.ac.jp Kunihito Matsui Professor Dept. of Civil and Environmental Engineering, Tokyo Denki University Hatoyama-Cho, Hiki...-Gun, Saitama 350-0394, JAPAN Tel.: +81-492-96-2911 Fax: +81-492-96-6501 matsui@g.dendai.ac.jp Takemi Inoue Executive Managing Director NIPPO Corporation 19-11 Kyobashi 1-Chome. Chuo-Ku, Tokyo 104-8380, JAPAN Tel.: +81-3-3563-6760 Fax: +81...

Metabolic effect of combined telmisartan and nifedipine CR therapy in patients with essential hypertension

Directory of Open Access Journals (Sweden)

Shimizu Y

2012-09-01

Full Text Available Yuji Shimizu,1,4 Fumiyasu Yamasaki,4 Takashi Furuno,1,4 Toru Kubo,1 Takayuki Sato,3,4 Yoshinori Doi,1 Tetsuro Sugiura21Medicine and Geriatrics, 2Clinical Laboratory, 3Cardiovascular Control, Kochi Medical, School, Nankoku, Japan; 4Section of Cardiology, Inoue Hospital, Takaoka, JapanBackground: In addition to exerting a blood pressure (BP-lowering effect, telmisartan produces favorable metabolic effects via peroxisome proliferator-activated receptor γ activation. While a combination of telmisartan and a calcium channel blocker is often used to achieve a target BP level, the metabolic effects of this drug combination remain unclear. Therefore, this study evaluated the metabolic effects of telmisartan plus nifedipine controlled release (CR therapy, in hypertensive patients without metabolic disease.Methods: Sixteen patients with essential hypertension, who had not undergone antihypertensive therapy in the previous 6 months, were studied. Patients were initiated on telmisartan (40 mg/day. If their office BP was not reduced to 140/90 mmHg after 6 weeks, nifedipine CR (20–40 mg per day was added for 18 weeks. The other patients whose BP had achieved the target of 140/90 mmHg, continued only telmisartan.Results: Telmisartan reduced BP (174 ± 13/92 ± 10 to 143 ± 22/78 ± 11 mmHg; P < 0.01 at 6 weeks in 16 patients, but eight patients did not achieve target BP levels and required addition of nifedipine. Telmisartan also resulted in a reduction in the homeostatic model assessment of insulin resistance (HOMA-IR (1.30 ± 0.65 to 1.10 ± 0.42; P < 0.05 at 6 weeks, but did not affect adiponectin or leptin levels. Addition of nifedipine (n = 8 resulted in a reduction in BP (158 ± 18/80 ± 13 to 131 ± 8/73 ± 13 mmHg; P < 0.01 at 18 weeks, but did not affect the HOMA-IR (1.10 ± 0.40 to 1.02 ± 0.56; ns. In patients who did not require addition of nifedipine (n = 8, BP levels remained nearly identical at 18 weeks (127 ± 13/73 ± 9 to 128 ± 13/68 ± 8

Kahekõne jaapani kunstiga / Anni Kagovere

Index Scriptorium Estoniae

Kagovere, Anni

2011-01-01

Jaapani kunstnike Jun Konishi, Shunichiro Nakashima ja Michihiro Sato ehtekunsti näitus "2011: mere ääres - metsa taga" Tallinnas A-Galeriis 12. sept.-ni, koostajad Adolfas Šaulys ja Mari Relo-Šaulys. Jaapani keraamiku Nanako Kaji näitus "Aja joon" Tallinnas galeriis Hop 20. sept.-ni. Näitus on Kumus 16. ja 17. septembril toimuvate Jaapani päevade osa

Agricultural Use of Burkholderia (Pseudomonas) Cepacia: A Threat to Human Health?

Science.gov (United States)

1998-06-01

against fungal diseases and has potential as a bioremediation agent for breaking down recalcitrant herbicides and pesticides. However, B. cepacia is...need for pesticides and its ability to degrade complex herbicides and pesticides is harnessed for bioremediation . Molecular Epidemiology of B... sunflower wilt fungus and role of antifungal compounds in controlling disease. Appl Environ Microbiol 1992;58:1760-3. 36. Homma Y, Sato Z, Hirayama F

Coupled LBM-DEM Three-phase Simulation on Seepage of CO2 Stored under the Seabed.

Science.gov (United States)

Kano, Y.; Sato, T.

2017-12-01

Concerning the seepage of CO2 stored in a subsea formation, CO2 bubble/droplet rises to the sea-surface dissolving into the seawater, and the acidification of local seawater will be a problem. Previous research indicated that seepage rate and bubble size significantly affect its behaviour (Kano et al., 2009; Dewar et al., 2013). On the other hand, Kawada's experiments (2014) indicated that grain size affects formation of gas channels and bubbles through granular media. CO2 seepage through marine sediments probably shows similar behaviour. Additionally, such mobilisation and displacement of sand grains by gas migration may also cause capillary fracturing of CO2 in the reservoir and seal. To predict these phenomena, it is necessary to reveal three-phase behaviour of gas-water-sediment grains. We built gas-liquid-solid three-phase flow 3D simulator by coupling LBM-DEM program, and simulation results showed that the mobilisation of sand grain forms gas channels and affects bubble formation compared with that through solid porous media (Kano and Sato, 2017). In this presentation, we will report simulation results on effects of porosity, grain size and gas flow rate on the formation of gas channels and bubble and their comparison with laboratory experimental data. The results indicate that porosity and grain size of sand gravels affect the width of formed gas channels and resulting formed bubble size on the order of supposed seepage rate in the CO2 storage and that in most of experiment's conditions. References: Abe, S., Place, D., Mora, P., 2004. Pure. Appl. Geophys., 161, 2265-2277. (accessed Aug 01, 2017). Dewar, M., Wei, W., McNeil, D., Chen, B., 2013. Marine Pollution Bulletin 73(2), 504-515. Kano, Y., Sato, T., Kita, J., Hirabayashi, S., Tabeta, S., 2009. Int. J. Greenhouse Gas Control, Vol. 3(5), 617-625. Kano, Y. and Sato, T., 2017. In Proceeding of GHGT-13, Lausanne, Switzerland, Nov. 14-18, 2016. Kawada, R. 2014. Graduation thesis. Faculty of Engineering, The

Produkční funkce v makroekonomii

OpenAIRE

Koláčková, Adéla

2015-01-01

Diploma thesis is concerned with production functions and their utilization in macroeconomics. Theoretical part describes and summaries general knowledge about production functions and their basics in macroeconomic theory. Produc-tions functions are described from the point of productivity measurement and estimation of potential product. In theoretical part, indicators of productivity and their alternatives are sum up. Practical part is based on estimation of Cobb-Douglas, CES and Sato produc...

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

... S Sato H Schlagheck H-R Schmidt G Shabratova I Sibiriak T Siemiarczuk B C Sinha N Slavine K Söderström N Solomey G Sood S P Sørensen P Stankus G Stefanek P Steinberg E Stenlund D Stüken M Sumbera T Svensson M D Trivedi A Tsvetkov C Twenhöfel L Tykarski J Urbahn N V Eijndhoven W H V Heeringen G J V ...

JPRS Report, Science & Technology, Japan, 89 Sairas Symposium

Science.gov (United States)

1990-08-21

Electric) B2-5 Region Segmentation Process for Visual Data Mikio Fukase, Tsugito Maruyama, Takashi Uchiyama (Fujitsu Labs.) Osamu Okamoto, Isao Yamaguchi (N...Shigeoki Hirai, Tomomasa Sato (ETL) Tadao Hiruma (Meiji Univ.) B2-12 A Teleoperating Assembly System Hajime Morikawa, Nobuaki Takanashi, Norio Tagawa...Processing for Space Robot Teleoperation 230 Eiichi Ogawa, Shigeki Kuzuoka (Mitsubrshi Electric) B32-5 Region Segmentation Process for Visual Data 234 Mikio

JPRS Report, Science & Technology, Japan. Goto Quantum Magneto-Flux Logic Project.

Science.gov (United States)

1992-04-23

established infrastruc- T. Kobayashi Professor, Physics Department, ture technology, such as the minimal signal measure-Faculty of Science, Tokyo Uni...5th Josephson Electronics, p 103 ence Proceedings, p 1215 (1989) (1988) M. Sato, N. Fukazawa, P. Spee and E. Goto J. Yuyama, M. Kasuya, S. Kobayashi , R...a speed similar to the real number inner product Nobuaki Yoshida computation. Because the single precision inner product computation can be composed

Visual Search for Feature and Conjunction Targets with an Attention Deficit

OpenAIRE

Arguin, Martin; Joanette, Yves; Cavanagh, Patrick

1993-01-01

Brain-damaged subjects who had previously been identified as suffering from a visual attention deficit for contralesional stimulation were tested on a series of visual search tasks. The experiments examined the hypothesis that the processing of single features is preattentive but that feature integration, necessary for the correct perception of conjunctions of features, requires attention (Treisman & Gelade, 1980 Treisman & Sato, 1990). Subjects searched for a feature target (orientation or c...

Investigation on the effects of guava (Psidium guajava L.) infusions on germination, root tips and meristematic cells of Latuca sativa.

Science.gov (United States)

Luber, Jaquelini; Palmieri, Marcel J; Botelho, Carolina M; Rinaldo, Daniel; Andrade-Vieira, Larissa F

2015-01-01

Guava (Psidium guajava L.) is a plant often employed in popular medicine. Recently several studies have alerted about the toxicity of substances present in medicinal plants, which can pose risks to the human health. In this sense, the present work aimed to investigate the phytotoxic, cytotoxic and genotoxic action of three guava varieties - Paluma, Pedro Sato and Roxa ("purple") - on the plant test system Lactuca sativa L. Thus, macro- and microscopic evaluations were carried out for five infusion concentrations (2.5, 5.0, 10.0, 20.0 and 40.0 g.L(-1)) prepared from each variety. Distilled water was used as negative control. Chromatographic and spectroscopic analysis by HPLC-PAD indicated that the chemical composition of the infusion of Roxa is different than that of the infusions of the varieties Paluma and Pedro Sato. It was observed that seed germination and root growth in L. sativa exposed to infusions decreased with increasing infusion concentration, regardless of the tested cultivar. For the mitotic index, no statistical differences were observed. On the other hand, a significant increase in the frequency of cell cycle alterations was verified, especially for the highest concentrations tested. The cytogenotoxic effect was significant. Therefore, guava should not be used indiscriminately in popular medicine.

Sutureless intrascleral intraocular lens fixation with lamellar dissection of scleral tunnel

Directory of Open Access Journals (Sweden)

Kawaji T

2016-01-01

Full Text Available Takahiro Kawaji,1,2 Tomoki Sato,2 Hidenobu Tanihara11Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Chuo-ku, 2Sato Eye & Internal Medicine Clinic, Kumamoto, JapanPurpose: To report the results of sutureless scleral fixation of a posterior chamber intraocular lens (IOL by using our developed simple technique.Methods: We retrospectively reviewed the medical records of 48 eyes of 47 patients who underwent sutureless intrascleral IOL fixation by using our modified technique. A 25-gauge microvitreoretinal knife was used to perform sclerotomies and create limbus-parallel scleral tunnels with lamellar dissection in which the haptics were fixed.Results: The IOLs were fixed and centered well. The mean follow-up period was 26.7 months. Postoperative complications included smooth vitreous hemorrhage in four eyes (8.3%, cystoid macular edema in two eyes (4.2%, and iris capture of the IOL in two eyes (4.2%. No other complications, such as breakage of the IOL, spontaneous IOL dislocation, or retinal detachment, were detected during the follow-up period.Conclusion: The lamellar dissection of the limbus-parallel scleral tunnel can simplify the forceps-assisted introduction of the haptics into the scleral tunnel, and this technique seemed to be safe.Keywords: intraocular lenses, ophthalmologic surgical procedures, intrascleral fixation, sutureless fixation

Investigation on the effects of guava (Psidium guajava L. infusions on germination, root tips and meristematic cells of Latuca sativa

Directory of Open Access Journals (Sweden)

Jaquelini Luber

2015-06-01

Full Text Available Guava (Psidium guajava L. is a plant often employed in popular medicine. Recently several studies have alerted about the toxicity of substances present in medicinal plants, which can pose risks to the human health. In this sense, the present work aimed to investigate the phytotoxic, cytotoxic and genotoxic action of three guava varieties - Paluma, Pedro Sato and Roxa ("purple" - on the plant test system Lactuca sativa L. Thus, macro- and microscopic evaluations were carried out for five infusion concentrations (2.5, 5.0, 10.0, 20.0 and 40.0 g.L-1 prepared from each variety. Distilled water was used as negative control. Chromatographic and spectroscopic analysis by HPLC-PAD indicated that the chemical composition of the infusion of Roxa is different than that of the infusions of the varieties Paluma and Pedro Sato. It was observed that seed germination and root growth in L. sativa exposed to infusions decreased with increasing infusion concentration, regardless of the tested cultivar. For the mitotic index, no statistical differences were observed. On the other hand, a significant increase in the frequency of cell cycle alterations was verified, especially for the highest concentrations tested. The cytogenotoxic effect was significant. Therefore, guava should not be used indiscriminately in popular medicine.

XXZ scalar products and KP

International Nuclear Information System (INIS)

Foda, O.; Wheeler, M.; Zuparic, M.

2009-01-01

Using a Jacobi-Trudi-type identity, we show that the scalar product of a general state and a Bethe eigenstate in a finite-length XXZ spin-1/2 chain is (a restriction of) a KP τ function. This leads to a correspondence between the eigenstates and points on Sato's Grassmannian. Each of these points is a function of the rapidities of the corresponding eigenstate, the inhomogeneity variables of the spin chain and the crossing parameter.

Geomorphic and Sedimentation Investigation of the 15 June 1991 Eruption of Mount Pinatubo, the Philippines

Science.gov (United States)

1994-05-01

IS45 TABIL WS A•.Wn Sato Tomw River sedia fd c in milion a ....... .- 50 TABLE 8 WACE a PHIVOLCUSGS mdia vtkams in millio c’...... B-54...process. For purposes of economic analysis, the potential deposition reaches were divided into inner and outer zones, and probabilities of being...natural variations in sediment yields that are useful in assessing the potential damages or economic benefits. The internal formulation of the model is

Single-leg squats can predict leg alignment in dancers performing ballet movements in “turnout”

OpenAIRE

Hopper,Luke S; Sato,Nahoko; Weidemann,Andries L

2016-01-01

Luke S Hopper,1 Nahoko Sato,2 Andries L Weidemann1 1Western Australian Academy of Performing Arts, Edith Cowan University, Mt Lawley, WA, Australia; 2Department of Physical Therapy, Nagoya Gakuin University, Seto, Japan Abstract: The physical assessments used in dance injury surveillance programs are often adapted from the sports and exercise domain. Bespoke physical assessments may be required for dance, particularly when ballet movements involve “turning out” or external...

JPRS Report Science & Technology Europe Twenty-Fourth Isata International Symposium on Automotive Technology and Automation.

Science.gov (United States)

1991-09-05

Hirayama, Association of Electronic Technology for Automobile Traffic and Driving and Y Ishii, Oki Electric Industry, Japan " Mazda Car Communication...System" Mazda Car Corporation, FRG IMPROVING TRAFFIC FLOW "Strategies for Integrating Dynamic Route Guidance and Traffic Control Systems" MGH Bell...Chemical Structure by Means of Exafs" N Sato, Honda R&D Co. Ltd and T Minami, Honda Motor Co. Ltd, Japan 155 910904 "Microstructural and Hardness

Dynamical coupled channel approach to omega meson production

Energy Technology Data Exchange (ETDEWEB)

Mark Paris

2007-09-10

The dynamical coupled channel approach of Matsuyama, Sato, and Lee is used to study the $\\omega$--meson production induced by pions and photons scattering from the proton. The parameters of the model are fixed in a two-channel (\\omega N,\\pi N) calculation for the non-resonant and resonant contributions to the $T$ matrix by fitting the available unpolarized differential cross section data. The polarized photon beam asymmetry is predicted and compared to existing data.

Cyanide- and phenoxo-bridged heterobimetallic Fe(III)-Mn(III ...

Indian Academy of Sciences (India)

134 5083. 6. Jeon I R, Calancea S, Panja A, Piñero Cruz D M,. Koumousi E S, Dechambenoit P, Coulon C, Wattiaux A,. Rosa P, Mathonière C and Clérac R 2013 Chem. Sci. 4. 2463. 7. (a) Liu C M, Xiong R G, Zhang D Q and Zhu D B 2010J. Am. Chem. Soc. 132 4044; (b) Zhang Y Z and Sato O. 2010 Inorg. Chem. 49 1271.

Neobvyklá žilná hornina ze štoly pod Matčinou horou u Zbiroha

Czech Academy of Sciences Publication Activity Database

Breiter, K.; Žák, Karel

2007-01-01

Roč. 2006, - (2007), s. 120-124 ISSN 0514-8057 Institutional research plan: CEZ:AV0Z30130516 Keywords : basic dyke rock * Teplá-Barrandian Unit * Bohemicum Subject RIV: DB - Geology ; Mineralogy http://www.geology.cz/zpravy/obsah/2006/2006-str.120-124.pdf

Some exact results for the two-point function of an integrable quantum field theory

International Nuclear Information System (INIS)

Creamer, D.B.; Thacker, H.B.; Wilkinson, D.

1981-01-01

The two-point correlation function for the quantum nonlinear Schroedinger (one-dimensional delta-function gas) model is studied. An infinite-series representation for this function is derived using the quantum inverse-scattering formalism. For the case of zero temperature, the infinite-coupling (c→infinity) result of Jimbo, Miwa, Mori, and Sato is extended to give an exact expression for the order-1/c correction to the two-point function in terms of a Painleve transcendent of the fifth kind

Sources of organic matter and microbial community structure in the sediments of the Visakhapatnam Harbour, east coat of India

Digital Repository Service at National Institute of Oceanography (India)

Harji, R.R; Bhosle, N.B.; Garg, A.; Sawant, S.S.; Venkat, K.

Trench at 11,000 m. Deep Sea Research Part I: Oceanographic Research Papers 47, 1173- 1182. Fang, J., Kato, C., Sato, T., Chan, O., McKay, D., 2004. Biosynthesis and dietary uptake of polyunsaturated fatty acids by peizophilic bacteria. Comparative... lipids and community structure in estuaries. Aquatic Microbial Ecology 42, 105-117. Hedges, J.I., Keil, R.G., 1995. Sedimentary organic matter preservation: an assessment and speculative synthesis. Marine Chemistry 49, 81-115. Hedges, J.I., Keil, R...

Genome-Wide Association Study of a Validated Case Definition of Gulf War Illness in a Population-Representative Sample

Science.gov (United States)

2013-09-01

neuropsychological [10, 11] , neurophysiological [10, 12] , auto- nomic [13] , brain imaging [7, 14–16] and functional status [17] measures, with...Craig Hill and Robert E. Mason. E. William Byrd Jr., Michael E. Murray, Helen Koo and a team of RTI staff contributed to the design of reproductive and...152: 992–1002. 19 Poblete PP, Araneta MRG, Sato PA, Hilio- poulos KM, Kamens DR, Morn CB, Zau AC, Gray GC: National study on reproductive outcomes

Opisthorchis viverrini: Detection by polymerase chain reaction (PCR) in human stool samples

Digital Repository Service at National Institute of Oceanography (India)

Umesha, K.R.; SanathKumar; Parvathi, A.; Duenngai, K.; Sithithaworn, P.; Karunasagar, Indrani; Karunasagar, Iddya

Journal of Tropical Medicine and Public Health 22 (Suppl.), 174–178. Duenngai, K., Sithithaworn, P., Rudrappa, U.K., Karunasagar, I., Laha, T., Stensvold, C.R., Strandgaard, H., Johansen, M.V., 2008. Improvement of PCR for detection of Opisthrochis... and lecithodendriid trematodes. Southeast Asian Journal of Tropical Medicine and Public Health 22, 623–630. Kobayashi, J., Vannachone, B., Sato, Y., Manivong, K., Nambanya, S., Inthakone, S., 2000. An epidemiological study on Opisthorchis viverrini infection in Lao...

XXZ scalar products and KP

Energy Technology Data Exchange (ETDEWEB)

Foda, O. [Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria 3010 (Australia)], E-mail: foda@ms.unimelb.edu.au; Wheeler, M. [Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria 3010 (Australia)], E-mail: mwheeler@ms.unimelb.edu.au; Zuparic, M. [Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria 3010 (Australia)], E-mail: mzup@ms.unimelb.edu.au

2009-10-21

Using a Jacobi-Trudi-type identity, we show that the scalar product of a general state and a Bethe eigenstate in a finite-length XXZ spin-1/2 chain is (a restriction of) a KP {tau} function. This leads to a correspondence between the eigenstates and points on Sato's Grassmannian. Each of these points is a function of the rapidities of the corresponding eigenstate, the inhomogeneity variables of the spin chain and the crossing parameter.

Some exact results for the two-point function of an integrable quantum field theory

International Nuclear Information System (INIS)

Creamer, D.B.; Thacker, H.B.; Wilkinson, D.

1981-02-01

The two point correlation function for the quantum nonlinear Schroedinger (delta-function gas) model is studied. An infinite series representation for this function is derived using the quantum inverse scattering formalism. For the case of zero temperature, the infinite coupling (c → infinity) result of Jimbo, Miwa, Mori and Sato is extended to give an exact expression for the order 1/c correction to the two point function in terms of a Painleve transcendent of the fifth kind

Neuropilin 2: Novel Biomarker and Therapeutic Target for Aggressive Prostate Cancer

Science.gov (United States)

2016-11-01

Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer . J. Urol. 175, 1245–1252 (2006). 130. Sato, K. et al...Expression of vascular endothelial growth factor gene and its receptor (flt-1) gene in urinary bladder cancer . Tohoku J. Exp. Med. 185, 173–184 (1998). R...inhibition should improve the efficacy of these therapies significantly. 15. SUBJECT TERMS Prostate cancer , VEGF, Neuropilin, IGF-1 receptor , PTEN, stem

The Effect of Marginal Seal of Veneering DiCor (trade name) Substrates with DiCor Plus Porcelain

Science.gov (United States)

1991-05-01

require less surface colorant. This combined with the darkness of the oral cavity may lower the value and give a restoration a gray appearance. 6. Minimal...of oral microbiota by cast glass-ceramic restoration. Int. J. Periodontics Restorative Dent. 2:23-35. Schaerer, P., Sato, T., and Wohlwend, A. 1988...or alloys containing zinc. He noted that cavity preparation had to be altered by making non-bevelled "square margins." As for fit, he reported it

Online EM with weight-based forgetting

OpenAIRE

Celaya, Enric; Agostini, Alejandro

2015-01-01

In the on-line version of the EM algorithm introduced by Sato and Ishii (2000), a time-dependent discount factor is introduced for forgetting the effect of the old posterior values obtained with an earlier, inaccurate estimator. In their approach, forgetting is uniformly applied to the estimators of each mixture component depending exclusively on time, irrespective of the weight attributed to each unit for the observed sample. This causes an excessive forgetting in the less frequently sampled...

Stemcell Information: SKIP000474 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available Gideon ... Fetus Unknown ... -- No MRC-iPS-62|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like Res... SKIP000474 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-62 MRC-iPS-62 Gideon...459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.--D...NA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Itaku...med/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000494 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available eyes Snake eyes ... Fetus Unknown ... -- No MRC-iPS-83|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-... SKIP000494 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-83 MRC-iPS-83 Snake ....2010.01459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cell...s.--DNA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue ....gov/pubmed/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000498 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available y Diggity ... Fetus Unknown ... -- No MRC-iPS-86|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like R... SKIP000498 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-86 MRC-iPS-86 Diggit...01459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.-...-DNA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Ita...ubmed/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000433 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available pper Gobstopper ... Fetus Unknown ... -- No MRC-iPS-21|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-... SKIP000433 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-21 MRC-iPS-21 Gobsto....2010.01459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cell...s.--DNA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue ....gov/pubmed/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000478 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available g ... Fetus Unknown ... -- No MRC-iPS-66|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like Research ... SKIP000478 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-66 MRC-iPS-66 Tug Tu...-10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.--DNA met...hylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Itakura Y, ...155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000457 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available s Jimmies ... Fetus Unknown ... -- No MRC-iPS-45|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like R... SKIP000457 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-45 MRC-iPS-45 Jimmie...01459.x--10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.-...-DNA methylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Ita...ubmed/21155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000437 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available c ... Fetus Unknown ... -- No MRC-iPS-25|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like Research ... SKIP000437 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-25 MRC-iPS-25 Tic Ti...-10.1371/journal.pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.--DNA met...hylation dynamics in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Itakura Y, ...155951--http://www.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Stemcell Information: SKIP000444 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available b ... Fetus Unknown ... -- No MRC-iPS-32|MRC5-derived iPS cells| MRC5由来iPS細胞| human ES-like Research ... SKIP000444 ... fetal lung fibroblast 胎児肺線維芽細胞 Unknown MRC-iPS-32 MRC-iPS-32 Bob Bo....pgen.1002085 Lectin microarray analysis of pluripotent and multipotent stem cells.--DNA methylation dynamic...s in human induced pluripotent stem cells over time. Toyoda M, Yamazaki-Inoue M, Itakura Y, Kuno A, Ogawa T,...ww.ncbi.nlm.nih.gov/pubmed/21637780 -- Some of clones of the same original cells have been used in the papers.

Le Corps de l'ennemi. Pratiques et représentations autour des cadavres ennemis dans la Première Guerre mondiale

Directory of Open Access Journals (Sweden)

Michel Vallo

2010-05-01

Full Text Available Thèse soutenue le 15 juin 2009.Composition du juryStéphane Audoin - Rouzeau (directeur de thèse, Annette Becker (présidente du jury, Leonard  V. Smith, Carine Trevisan, Georges Vigarello.Mention : Très Honorable avec félicitations du jury à l’unanimité.RésuméLes cadavres des adversaires occupent une place majeure dans l’expérience combattante et dans l’imaginaire des sociétés belligérantes de la Première Guerre mondiale, qui connut une mortalité inouïe, une immobilisation des fronts, et la ...

[The Chinese nuclear test and 'atoms for peace' as a measure for preventing nuclear armament of Japan: the nuclear non-proliferation policy of the United States and the introduction of light water reactors into Japan, 1964-1968].

Science.gov (United States)

Yamazaki, Masakatsu

2014-07-01

Japan and the United States signed in 1968 a new atomic energy agreement through which US light-water nuclear reactors, including those of the Fukushima Daiichi Nuclear Power Plant of Tokyo Electric Power Company, were to be introduced into Japan. This paper studies the history of negotiations for the 1968 agreement using documents declassified in the 1990s in the US and Japan. After the success of the Chinese nuclear test in October 1964, the United States became seriously concerned about nuclear armament of other countries in Asia including Japan. Expecting that Japan would not have its own nuclear weapons, the US offered to help the country to demonstrate its superiority in some fields of science including peaceful nuclear energy to counter the psychological effect of the Chinese nuclear armament. Driven by his own political agenda, the newly appointed Prime Minister Eisaku Sato responded to the US expectation favorably. When he met in January 1965 with President Johnson, Sato made it clear that Japan would not pursue nuclear weapons. Although the US continued its support after this visit, it nevertheless gave priority to the control of nuclear technology in Japan through the bilateral peaceful nuclear agreement. This paper argues that the 1968 agreement implicitly meant a strategic measure to prevent Japan from going nuclear and also a tactic to persuade Japan to join the Nuclear Non -Proliferation Treaty.

The CIRP International Workshop on Concurrent Engineering for Product Realization (1st) Held in Tokyo, Japan on June 27 - 28, 1992

Science.gov (United States)

1992-11-01

7075 Dr. Samuel K.M.HO Dept. of Engineering Warwick University Coventry CV 47 AL UK 15 Tel.(44)203 524173 Fax.(44)203 524307 Mr. Mikio Inagaki...Nishi-8, Kita-ku Sapporo 060, JAPAN Tel. +81-11-716-211 ex.6447 Fax. +81-11-758-1619 Mr. Mikio Kitano 16 Motomachi Plant Toyota Moter Corporation 1...Hirosawa 2-1, Wako, Saitama 351-01 JAPAN Tel 81-484-65-6641 Fax 81-484-67-5942 Professor Hisayoshi Sato Director, Mechanical Engineering Laboratory

Molecular Cloning and Function of FAS/APO1 Associated Protein in Breast Cancer.

Science.gov (United States)

1996-06-01

Ariyama T, Abe T, Druck T, Ohta M, Huebner K, Yanagisawa J, Reed JC, Sato T: PTPN13, a Fas-associated protein tyrosine phosphatase, is located on...20. Yang, Q., and Tonks, N. K. (1991). Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology 7. Huebner, K., Druck , T...Acad. Sci. U.S.A. 91, 7477 (1994). Res. 53, 1945 (1993).(Fig. 3D ). In contrast to Jurkat cells which 13. The original description of PTP-BAS (12

Distribution and sources of aliphatic hydrocarbons and fatty acids in surface sediments of a tropical estuary south west coast of India (Cochin estuary)

Digital Repository Service at National Institute of Oceanography (India)

Gireeshkumar, T.R.; Deepulal, P.M.; Chandramohanakumar, N.

acid biomarkers and stable isotopes. Estuarine, Coastal and Shelf Science, 70, 271–286. Andrews, J. E., Greenaway, A. M., & Dennis, P. F. (1998). Combined carbon isotope and C/N ratios as indictors of source and fate of organic matter in a poorly.... (1997). Even n- alkane predominances on the Amazon Shelf and a Northeast Pacific Hydrothermal System. Naturwissenschaften, 84, 415–420. Fang, J., Kato, C., Sato, T., Chan, O., & McKay, D. (2004). Biosynthesis and dietary uptake of polyunsaturated fatty...

Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model

OpenAIRE

Sato, Toshimi; Alles, Neil; Khan, Masud; Nagano, Kenichi; Takahashi, Mariko; Tamura, Yukihiko; Shimoda, Asako; Ohya, Keiichi; Akiyoshi, Kazunari; Aoki, Kazuhiro

2015-01-01

Toshimi Sato,1 Neil Alles,1,2 Masud Khan,1,3 Kenichi Nagano,1,4 Mariko Takahashi,1 Yukihiko Tamura,1 Asako Shimoda,5,6 Keiichi Ohya,1 Kazunari Akiyoshi,5,6 Kazuhiro Aoki1 1Department of Bio-Matrix (Pharmacology), Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; 2Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka; 3Department of Dental Pharmacology, City Dental College and Hospital, Dhaka, Bangladesh; 4Department of Oral Medicin...

Therapeutic Targeting of Spliceosomal-Mutant Acquired Bone Marrow Failure Disorders

Science.gov (United States)

2017-05-01

spliceosomal mutant cells . This effort has also highlighted a requirement for innate immune signaling in SF3B1-mutant MDS and has implicated a few specific...relative to single-mutant cells (Figure 5A). As innate immune signaling has been implicated in MDS pathogenesis (Basiorka et al., 2016; Fang et al...Sato et al., 2005; Tang et al., 2008; Vink et al., 2013; Xin et al., 2017). Here, we observed that SF3B1K700E/+ human lymphoid leukemia cells (NALM-6

Dilemmas in Forward Basing: Understanding the Impact of the American Military Presence in Bahrain

Science.gov (United States)

2014-06-01

Brazil , or Peru.49 Of the 3218 settlers sent to Colonia Okinawa, from the 1950s to early 1960s only 806 remained by the year 2000. Those who remained...protest rally at a local high school that drew 10,000 people to the streets. A torch lit procession found its way to the hotel where Sato was...overnight rather than return to his off base hotel . This act of seeking refuge with the Americans did little to gain him favor with the left. Despite the

Microlocal study of S-matrix singularity structure

International Nuclear Information System (INIS)

Kawai, Takahiro; Kyoto Univ.; Stapp, H.P.

1975-01-01

Support is adduced for two related conjectures of simplicity of the analytic structure of the S-matrix and related function; namely, Sato's conjecture that the S-matrix is a solution of a maximally over-determined system of pseudo-differential equations, and our conjecture that the singularity spectrum of any bubble diagram function has the conormal structure with respect to a canonical decomposition of the solutions of the relevant Landau equations. This latter conjecture eliminates the open sets of allowed singularities that existing procedures permit. (orig.) [de

Legume and Lotus japonicus Databases

DEFF Research Database (Denmark)

Hirakawa, Hideki; Mun, Terry; Sato, Shusei

2014-01-01

Since the genome sequence of Lotus japonicus, a model plant of family Fabaceae, was determined in 2008 (Sato et al. 2008), the genomes of other members of the Fabaceae family, soybean (Glycine max) (Schmutz et al. 2010) and Medicago truncatula (Young et al. 2011), have been sequenced. In this sec....... In this section, we introduce representative, publicly accessible online resources related to plant materials, integrated databases containing legume genome information, and databases for genome sequence and derived marker information of legume species including L. japonicus...

New preparations of the elemental diet and the clinical application.

Science.gov (United States)

Ogoshi, S; Sato, H

1981-01-01

In 1978, we designed a new elemental diet, ED-AC, which modified after Vivonex-HN with the co-operation of Ajinomoto Co., Japan and Morton-Norwich Co., U.S.A.. ED-AC is now being used widely in Japan for enteral hyper-alimentation, even in case of pediatric surgery. We have new prepared another elemental diet, this time for infants, ED-P (pediatric). The ratio of amino acids in both ED was determined according the proposal of Professor Goro Inoue, Department of Nutrition, Tokushima University. The application of ED, particularly for surgical patients, has been most effective. the use of this diet for enteral hyperalimentation should find a wide application in surgical and medical practice.

Liquid -to-glass transition in bulk glass-forming Cu55-xZr45Agx alloys using molecular dynamic simulations

Directory of Open Access Journals (Sweden)

Celtek M.

2011-05-01

Full Text Available We report results from molecular dynamics (MD studies concerning the microscopic structure of the ternary, bulk metallic glass-forming Cu55-x Zr45Agx (x=0,10,20 alloys using tight-binding potentials. Understanding of the nature of Glass Forming Ability (GFA of studied alloys, GFA parameters, glass transition temperature (T-g, melting temperature (T-m, reduced glass transition temperature (T-g/T-m, the supercooled liquid region and other parameters were simulated and compared with experiments. The computed pair distribution functions reproduce well experimental x-ray data of Inoue and co-workers. Structure analysis of the Cu-Zr-Ag alloy based on MD simulation will be also presented

Pressure drop of magnetohydrodynamic two-phase annular flow in rectangular channel

International Nuclear Information System (INIS)

Kumamaru, Hiroshige; Fujiwara, Yoshiki; Ogita, Kenji

1999-01-01

Numerical calculations have been performed on magnetohydrodynamic (MHD) two-phase annular flow in a rectangular channel with a small aspect ratio, i.e.a small ratio of the channel side perpendicular to the applied magnetic field and the side parallel to the field. Results of the present calculation agree nearly with Inoue et al.'s experimental results in the region of large liquid Reynolds numbers and large Hartmann numbers. Calculation results also show that the pressure drop ratio, i.e. the ratio of pressure drop of two-phase flow to that of single-phase flow under the same liquid flow rate and applied magnetic field, becomes lower than ∼0.02 for conditions of a fusion reactor plant. (author)

Enhancement of the Enterocin CRL35 Activity by a Synthetic Peptide Derived from the NH2-Terminal Sequence

Science.gov (United States)

Saavedra, Lucila; Minahk, Carlos; de Ruiz Holgado, Aída P.; Sesma, Fernando

2004-01-01

The enterocin CRL35 biosynthetic gene cluster was cloned and sequenced. The sequence was revealed to be highly identical to that of the mundticin KS gene cluster (S. Kawamoto, J. Shima, R. Sato, T. Eguchi, S. Ohmomo, J. Shibato, N. Horikoshi, K. Takeshita, and T. Sameshima, Appl. Environ. Microbiol. 68:3830-3840, 2002). Short synthetic peptides were designed based on the bacteriocin sequence and were evaluated in antimicrobial competitive assays. The peptide KYYGNGVSCNKKGCS produced an enhancement of enterocin CRL35 antimicrobial activity in a buffer system. PMID:15215149

Preventing Factory Fires through Contracts: Case study of Garment Factories in Bangladesh

Directory of Open Access Journals (Sweden)

Sato Hideki

2015-04-01

Full Text Available Following a multi-decade history of lethal fires in the Bangladeshi garment industry, Sato (2012 proposed a contract framework that encourages manufacturers to adopt measures that reduce loss of life. Apart from the humanitarian imperative, the manufacturer has an incentive to sign the contract and adopt its preventative measures because an industrial disaster will cancel its relationship with its global retailer and end the related profits. This theoretical study specifies the optimal contract that incentivizes manufacturers and reduces the occurrence of garment industry fires.

A danger of induction of Brugada syndrome during pill-in-the-pocket therapy for paroxysmal atrial fibrillation

Directory of Open Access Journals (Sweden)

Yoshiyasu Aizawa

2010-08-01

Full Text Available Yoshiyasu Aizawa, Tomohiro Matsuhashi, Toshiaki Sato, Seiji Takatsuki, Keiichi FukudaDivision of Cardiology, Keio University School of Medicine, Tokyo, JapanAbstract: Rhythm control therapy by sodium channel blockers is widely performed for the ­treatment of paroxysmal atrial fibrillation. Here, we present a case of acquired Brugada ­syndrome by pill-in-the-pocket treatment using pilsicainide. It is important that this therapy should be applied only after confirming the drug safety to the patients.Keywords: syncope, sudden death, drug, rhythm control, pilsicainide, atrial flutter

Cobinding of bilirubin and laurate to human serum albumin: spectroscopic characterization of stoichiometric complexes

DEFF Research Database (Denmark)

Honoré, B; Sato, H; Brodersen, R

1988-01-01

Light absorption and CD spectra of bound bilirubin and albumin fluorescence spectra have been recorded from mixtures containing albumin, A, bilirubin, B, and laurate, L, in Tris-NaCl buffer at pH 8.2, 25 degrees C. Concentrations of the corresponding stoichiometric complexes, ABiLj, for i = 0....../3 and j = 0/3, have been calculated from previously determined stoichiometric cobinding constants (H. Sato et al. (1988) Arch. Biochem. Biophys. 260, 811-821). Spectral data of the complexes have finally been found by iterative computer fitting using the principle of several acceptable solutions (R...

LEPS potential for H3 from force field data

International Nuclear Information System (INIS)

Varandas, A.J.C.

1979-01-01

A new potential energy surface for H 3 of the London--Eyring--Polanyi--Sato type has been obtained which reproduces the best available estimates for the geometry, classical barrier height, and quadratic force constants of the D/sub infinityh/ saddle point. Other attributes of the surface, e.g., minimum energy profile for the exchange process, spherically averaged potential V 0 , and leading anisotropic potential V 2 , are also shown to be in good agreement with the best available estimates. The simplicity of its functional form further commends it for future dynamical studies

The Role of Fatty Acid Metabolism in Estrogen Receptor Negative Breast Cancer

Science.gov (United States)

2015-11-01

of a novel variant of isoform 6. Biochemistry 44 (5), 1635–1642. [31] Mashima T, Sato S, Okabe S, Miyata S, Matsuura M, Sugimoto Y, et al. (2009). Acyl... AMP and p38 mitogen-activated protein kinase.World J Gastroenterol 11, 2557–2563. [50] Sung KY, Hwang SY, Park MK, Bae HI, Kim WH, Kim JC, et al. (2003...Recombinant Long-Chain Rat Acyl-CoA Synthetase Isoforms 3 and 6: Identification of a Novel Variant of Isoform 6. Biochemistry 44: 1635-1642. doi:10.1021

A new approach to the self-dual Yang-Mills equations

International Nuclear Information System (INIS)

Takasaki, K.

1984-01-01

Inspired by Sato's new theory for soliton equations, we find a new approach to the self-dual Yang-Mills equations. We first establish a correspondence of solutions between the self-dual Yang-Mills equations and a new system of equations with infinitely many unknown functions. It then turns out that the latter equations can be easily solved by a simple explicit procedure. This leads to an explicit description of a very broad class of solutions to the self-dual Yang-Mills equations, and also to a construction of transformations acting on these solutions. (orig.)

A Machine Learning Approach to Test Data Generation

DEFF Research Database (Denmark)

Christiansen, Henning; Dahmcke, Christina Mackeprang

2007-01-01

been tested, and a more thorough statistical foundation is required. We propose to use logic-statistical modelling methods for machine-learning for analyzing existing and manually marked up data, integrated with the generation of new, artificial data. More specifically, we suggest to use the PRISM...... system developed by Sato and Kameya. Based on logic programming extended with random variables and parameter learning, PRISM appears as a powerful modelling environment, which subsumes HMMs and a wide range of other methods, all embedded in a declarative language. We illustrate these principles here...

A new form of collaboration in cultural anthropology: Matsutake worlds

DEFF Research Database (Denmark)

T. K, Choy,; Tsing, Anna

2009-01-01

Experiments in collaboration open new investigative possibilities for cultural anthropologists. In this report, we use our research on matsutake mushrooms to show the promise of collaborative experiments for ethnographers of scale making, global connection, and human–nonhuman relations. Anna Tsing...... introduces. Mogu Mogu (Timothy Choy and Shiho Satsuka) argue that the mushroomic figure of mycorrhizal life illuminates workings of capital and power, nature and culture. Lieba Faier examines contingency—through the effect of weather and bugs on matsutake production—as a form of self-positioning that emerges...... from local understandings of connection. Michael Hathaway uses postcolonial science studies to examine the transnational production, flow, and transformation of scientific knowledge about matsutake. Miyako Inoue discusses the anthropological subject that emerges through the kind of collaboration...

Au-delà des big data

OpenAIRE

Ollion, Étienne; Boelaert, Julien

2015-01-01

Dans le débat public comme dans le monde académique, l’enthousiasme pour les big data n’a eu d’égal que les critiques que ce phénomène a suscité. « Opportunité empirique inouïe » vs « données pauvres » ; « révolution méthodologique » vs « fascination pour le nombre » ; « révolution scientifique » vs « dégradation du savoir produit » : les positions sont tranchées. À partir d’une lecture de ces débats et des travaux en sciences sociales souvent regroupés sous ce label, l’article soutient que c...

A new genus of Eastern Hemisphere stingless bees (Hymenoptera, Apidae), with a key to the supraspecific groups of Indomalayan and Australasian Meliponini

DEFF Research Database (Denmark)

Rasmussen, Claus; Thomas, Jennifer C.; Engel, Michael S.

2017-01-01

and is more closely related to Lepidotrigona Moure. The species is transferred to Wallacetrigona Engel and Rasmussen, new genus, and differentiated from Geniotrigona proper as well as all other meliponines occurring in Sundaland, Wallacea, and Sahul (Australinea). The new genus occurs east of the Wallace Line...... and separate from the distribution of Geniotrigona, which is otherwise restricted to Sundaland, but Wallacetrigona is presently not known beyond the Weber Line. A hierarchical classification of Indomalayan and Australasian stingless bees is tabulated and a revised key to the genera and subgenera provided......, as well as an appendix tabulating the species and synonyms. The following new combinations are established: Wallacetrigona incisa (Sakagami and Inoue), Homotrigona (Lophotrigona) canifrons (Smith), Homotrigona (Odontotrigona) haematoptera (Cockerell), Homotrigona (Tetrigona) apicalis (Smith), H. (T...

Simulating topographic controls on the abundance of larch forest in eastern Siberia, and its consequences under changing climate

Science.gov (United States)

Sato, H.; Kobayashi, H.

2017-12-01

In eastern Siberia, larches (Larix spp.) often exist in pure stands, constructing the world's largest coniferous forest, of which changes can significantly affect the earth's albedo and the global carbon balance. Our previous studies tried to reconstruct this vegetation, aiming to forecast its structures and functions under changing climate (1, 2). In previous studies of simulating vegetation at large geographical scales, the examining area is divided into coarse grid cells such as 0.5 × 0.5 degree resolution, and topographical heterogeneities within each grid cell are just ignored. However, in Siberian larch area, which is located on the environmental edge of existence of forest ecosystem, abundance of larch trees largely depends on topographic condition at the scale of tens to hundreds meters. In our preliminary analysis, we found a quantitative pattern that topographic properties controls the abundance of larch forest via both drought and flooding stresses in eastern Siberia. We, therefore, refined the hydrological sub-model of our dynamic vegetation model SEIB-DGVM, and validated whether the modified model can reconstruct the pattern, examined its impact on the estimation of biomass and vegetation productivity under the current and forecasted future climatic conditions. -- References --1. Sato, H., et al. (2010). "Simulation study of the vegetation structure and function in eastern Siberian larch forests using the individual-based vegetation model SEIB-DGVM." Forest Ecology and Management 259(3): 301-311. 2. Sato, H., et al. (2016). "Endurance of larch forest ecosystems in eastern Siberia under warming trends." Ecology and Evolution

Socio-technological impact analysis using an energy IO approach to GHG emissions issues in South Korea

International Nuclear Information System (INIS)

Chung, Whan-Sam; Tohno, Susumu; Choi, Ki-Hong

2011-01-01

Highlights: → Using the Sato-Vartia index for the three periods of 1985-1995, 1995-2000, and 2000-2005, the changes in three factors affecting GHG emissions in South Korea were analyzed. → A total emission matrix including both direct and indirect GHG emissions showed plain shape; however, ripple effects were observed in some sectors. → This process is useful in measuring national energy policies. → Several limitations of the Divisia decomposition analysis were pointed out. -- Abstract: Through energy input-output (E-IO) analyses from 1985 to 2005, the changes in three factors affecting GHG emissions in South Korea were analyzed. Based on the E-IO results, the changes in the direct and total (embodied) GHG emissions from the pertinent sectors were decomposed into three factors-the energy consumption effect, the social effect, and the technological effect-using the Sato-Vartia index for the three periods of 1985-1995, 1995-2000, and 2000-2005. The decomposition analysis demonstrated that a total emission matrix including both direct and indirect GHG emissions showed an evolution pattern that was very similar to the changes in direct GHG emissions; however, ripple effects were observed in the case of emissions from sector number -59 (Synthetic resins, synthetic rubber-p). The results showed that national energy policies such as those pertaining to the diversification of energy sources, shifts in the energy consumption structure (social effect), and the transformation to a low-carbon energy economy (technology effect) were effective. Finally, several limitations of the Divisia decomposition analysis were pointed out.

Polish-Bulgarian-Russian, Bulgarian-Polish-Russian or Russian-Bulgarian-Polish dictionary?

Directory of Open Access Journals (Sweden)

Violetta Koseska-Toszewa

2015-11-01

Full Text Available Polish-Bulgarian-Russian, Bulgarian-Polish-Russian or Russian-Bulgarian-Polish dictionary? The trilingual dictionary (M. Duszkin, V. Koseska, J. Satoła and A. Tzoneva is being elaborated based on a working Polish-Bulgarian-Russian electronic parallel corpus authored by Maksim Duszkin, Violetta Koseska-Toszewa and Joanna Satoła-Staśkowiak, and works by A. Tzoneva. It is the first corpus comparing languages belonging to three different Slavic language groups: western, southern and eastern. Works on the dictionary are based on Gramatyka konfrontatywna bułgarsko-polska (Bulgarian-Polish confrontative grammar and the proposed there semantic-oriented interlanguage. Two types of classifiers have been introduced into the dictionary: classic and semantic. The trilingual dictionary will present a consistent and homogeneous set of facts of grammar and semantics. The Authors point out that in a traditional dictionary it is not clear for example whether aspect should be understood as imperfective / perfective form of a verb or as its meaning. Therefore in the dictionary forms and meaning are separated in a regular way. Imperfective verb form has two meanings: state and configuration of states and events culminating in state. Also perfective verb form has two meanings: event and configuration of states and events culminating in event. These meanings are described by the semantic classifiers, respectively, state and event, state1 and event1. The way of describing language units, mentioned in the article, gives a possibility to present language material (Polish, Bulgarian, Russian in any required order, hence the article’s title.

The hydrotherapy in the treatment of patients with Chronic Obstructive Pulmonary Disease - doi:10.5020/18061230.2007.p221

Directory of Open Access Journals (Sweden)

Fernanda Gadelha Severino

2012-01-01

Full Text Available The Chronic Obstructive Pulmonary Disease (COPD is a serious, disabling disease, presenting the pulmonary function test with abnormalities in the expiratory flow. Under this denomination, it comprises the chronic bronchitis and pulmonary emphysema. The hydrotherapy involves the physical therapy with aquatic exercises and has being used because it is a pleasant activity with positive results. The aim of this exploratory study was to compare the performance of the patients with COPD treated with hydrotherapy associated to pulmonary rehabilitation with those treated only with pulmonary rehabilitation, being held in the cardiopulmonary rehabilitation center of Messejana Hospital, in Fortaleza - Ceará. The sample consisted of 10 patients, independently of sex and age, randomly divided into two groups. The evaluation instrument was the upper limbs incremental test observing the following parameters: the cardiac frequency (FC, the respiratory frequency (f, the degree of dyspnea, the tiredness of the upper limbs, the maximum burden reached and the oxygen saturation (SatO2. The parameters FC (p=0.04, f (p=0.046 e SatO2 (p=0.008 presented an average improvement of 33.33% above those of the patients that were just in the pulmonary rehabilitation. The other evaluated parameters also presented positive results, but with p>0.05. In conclusion, the results obtained with the pulmonary rehabilitation associated to the hydrotherapy overcome those found just with the pulmonary rehabilitation treatment, allowing an increase in the physical conditioning and improvement in the functional activities; although, due to the reduced number of cases, new researches should be held to confirm this exploratory study.

Modified Scoring, Traditional Item Analysis, and Sato's Caution Index Used To Investigate the Reading Recall Protocol.

Science.gov (United States)

Deville, Craig W.; Chalhoub-Deville, Micheline

A study demonstrated the utility of item analyses to investigate which items function well or poorly in a second language reading recall protocol instrument. Data were drawn from a larger study of 56 learners of German as a second language at various proficiency levels. Pausal units of scored recall protocols were analyzed using both classical…

The development of individual purposes: Creating actuality through novelty

DEFF Research Database (Denmark)

Valsiner, Jaan

2011-01-01

This chapter proposes a theoretical model to make sense of how any human being can face future challenges at the present through cultural signs: which particular forms the sign-construction takes, how deep (or shallow) the hierarchical structure of semiotic mediation is, and how temporary or quasi......-permanent it might be. The model is rooted in Vygotsky's focus on the dialectical nature of human development, and elaborated in life-course psychology by TEM (Trajectory Equifinality Model of Tatsuya Sato). The making of individual purposes is a process of anticipating the future relations with the changing context...

Effects of 3% diquafosol sodium ophthalmic solution on higher-order aberrations in patients diagnosed with dry eye after cataract surgery

Directory of Open Access Journals (Sweden)

Inoue Y

2016-12-01

Full Text Available Yasushi Inoue, Shintarou Ochi Inoue Eye Clinic, Tamano, Okayama, Japan Purpose: To evaluate the effects of diquafosol sodium ophthalmic solution 3% (DQS and artificial tears (AT on higher-order aberrations (HOAs in patients with dry eye after cataract surgery. Design: This was a post hoc analysis of a previously conducted randomized clinical study. Methods: Fifty-nine eyes from 42 patients (17 males and 25 females, aged 72.6±8.0 years with verified or suspected dry eye at 4 weeks after cataract surgery were evaluated. The dry eye patients were randomly assigned to receive DQS or AT for 4 weeks. Tear breakup time (BUT, corneal and conjunctival fluorescein staining scores, and HOAs were analyzed before and after instillation. HOAs were measured consecutively for 10 seconds with a wavefront analyzer. Average HOAs, HOA fluctuations (fluctuation index [FI] and changes in HOAs (stability index [SI] were compared within and between the two groups. Results: After 4 weeks of instillation, BUT significantly increased (P=0.001 compared with preinstillation values in the DQS group, but not in the AT group. This increase in BUT in the DQS group was significantly greater than in the AT group (P=0.014. Corneal and conjunctival fluorescein staining scores after instillation significantly improved compared with preinstillation values in the DQS group (P=0.018. In HOAs, the cornea aberration changed from an upward curve (a sawtooth pattern to an almost constant value (a stable pattern in the DQS group, but not in the AT group. In FI and SI, there were no significant changes in either group; however, FI and SI were significantly lower in the DQS group than in the AT group (both, P=0.004. Conclusion: The dry eye patients after cataract surgery had a visual dysfunction in HOAs. DQS is effective to treat dry eye disease after cataract surgery with improvement of visual function. Keywords: cataract surgery, dry eye, tear film breakup time, higher-order aberrations

ONLINE EDUCATION FOR LIFELONG LEARNING

Directory of Open Access Journals (Sweden)

Fatih Bayram

2007-07-01

Full Text Available This book was edited by, Yukiko Inoue, professor of educational research at the University of Guam, where she teaches online and face-to-face courses. It was published by Information Science Publishing in 2007. The authors of the chapters in this bookare selected from different universities from Guam,Australia, Turkey and Greece. Online education hasprovided considerable opportunities for all peoplein lifelong learning. People who use online learningmaterials has interactive medium for lifelonglearning. The aim of this book is to examine online environment in terms of development, implementation, theories, technology and case studies. It provides theoretical and practical information about online lifelong learning; consequently, it can appeal to researchers, practitioners, online learners and anyone interested in online lifelong learning. This book covers 14 chapters divided into fivesections.

A review of the genus Cephaloscyllium (Chondrichthyes: Carcharhiniformes: Scyliorhinidae) from Taiwanese waters.

Science.gov (United States)

Nakaya, Kazuhiro; Inoue, Shinsuke; Ho, Hsuan-Ching

2013-01-01

Sharks of the genus Cephaloscyllium from Taiwan were reviewed. After extensive survey of the specimens deposited in useums, universities and fisheries institutions in Taiwan and Japan, the following four species were recognized as valid n Taiwanese waters: C. umbratile Jordan & Fowler, 1903, C. fasciatum Chan, 1966, C. sarawakensis Yano, Ahmad & Gambang, 2005, and C. formosanum Teng, 1962. Cephaloscyllium formosanum is resurrected herein. Four species (C. circulopullum Yano, Ahmad & Gambang, 2005, C. parvum Inoue & Nakaya, 2006, C. pardelotum Schaaf-da Silva & Ebert, 2008, C. maculatum Schaaf-da Silva & Ebert, 2008) are concluded to be junior synonyms. The four valid species here recognized are fully described, and a key to Taiwanese species is provided. The original description of C. formosanum was translated into English from Japanese and is included as an Appendix.

Vietnamci a Česká republika. IV. část: Národnostní menšinou v ČR

Czech Academy of Sciences Publication Activity Database

Brouček, Stanislav

2015-01-01

Roč. 22, č. 12 (2015), s. 10-11 ISSN 1213-0249 Institutional support: RVO:68378076 Keywords : migration * diaspora * Vietnamese in the Czech Republic * migration policy Subject RIV: AC - Archeology, Anthropology, Ethnology

Magnetic resonance fingerprinting based on realistic vasculature in mice.

Science.gov (United States)

Pouliot, Philippe; Gagnon, Louis; Lam, Tina; Avti, Pramod K; Bowen, Chris; Desjardins, Michèle; Kakkar, Ashok K; Thorin, Eric; Sakadzic, Sava; Boas, David A; Lesage, Frédéric

2017-04-01

Magnetic resonance fingerprinting (MRF) was recently proposed as a novel strategy for MR data acquisition and analysis. A variant of MRF called vascular MRF (vMRF) followed, that extracted maps of three parameters of physiological importance: cerebral oxygen saturation (SatO 2 ), mean vessel radius and cerebral blood volume (CBV). However, this estimation was based on idealized 2-dimensional simulations of vascular networks using random cylinders and the empirical Bloch equations convolved with a diffusion kernel. Here we focus on studying the vascular MR fingerprint using real mouse angiograms and physiological values as the substrate for the MR simulations. The MR signal is calculated ab initio with a Monte Carlo approximation, by tracking the accumulated phase from a large number of protons diffusing within the angiogram. We first study the identifiability of parameters in simulations, showing that parameters are fully estimable at realistically high signal-to-noise ratios (SNR) when the same angiogram is used for dictionary generation and parameter estimation, but that large biases in the estimates persist when the angiograms are different. Despite these biases, simulations show that differences in parameters remain estimable. We then applied this methodology to data acquired using the GESFIDE sequence with SPIONs injected into 9 young wild type and 9 old atherosclerotic mice. Both the pre injection signal and the ratio of post-to-pre injection signals were modeled, using 5-dimensional dictionaries. The vMRF methodology extracted significant differences in SatO 2 , mean vessel radius and CBV between the two groups, consistent across brain regions and dictionaries. Further validation work is essential before vMRF can gain wider application. Copyright © 2017 Elsevier Inc. All rights reserved.

Shirataki obsidian exploitation and circulation in prehistoric northern Japan

Directory of Open Access Journals (Sweden)

Miyuki Yakushige

2014-03-01

Full Text Available Presently, the total number of archaeological obsidian sources in Japan is more than 80, and among them, 21 are in Hokkaido, northern part of the Japanese archipelago (Izuho and Sato 2007. Obsidian was the dominant of lithic raw material in the Upper Paleolithic Hokkaido (35-10 ka cal BP. Out of 21 archaeological obsidian sources in Hokkaido, 4 sources: Shirataki, Oketo, Tokachi, and Akaigawa are the major obsidian sources and the others are minor sources. Shirataki is one of the largest obsidian sources in Northeast Asia and it is well known that Shirataki obsidian was transported outside Hokkaido to Sakhalin and the Paleo-Honshu Island from the Late Upper Paleolithic period.We compiled data of obsidian source analyses conducted to artefacts from Paleolithic sites in Hokkaido, and it became clear that the ratio of Shirataki obsidian in all analyzed materials is more than half (Sato and Yakushige in press.We examined how far Shirataki obsidian was transported in each period: the Early Upper Paleolithic (35-25 ka cal BP and the Late Upper Paleolithic (25-10 ka cal BP. The Late Upper Paleolithic is divided into three stage, the early Early Microblade Industry (Stage 1: 25-21 ka cal BP, the late Early Microblade Industry (Stage 2: 19-16 ka cal BP, and the Late Microblade Industry (Stage 3: 16-10 ka cal BP. As a result, it is revealed that the distribution areas of Shirataki obsidian did not expand gradually over time, but are different in different lithic industries. In the background of this situation lay the difference of ecological adaptation strategies adopted by the prehistoric people of the time and their movement behavioral strategies.

Non-Hamiltonian generalizations of the dispersionless 2DTL hierarchy

International Nuclear Information System (INIS)

Bogdanov, L V

2010-01-01

We consider two-component integrable generalizations of the dispersionless two-dimensional Toda lattice (2DTL) hierarchy connected with non-Hamiltonian vector fields, similar to the Manakov-Santini hierarchy generalizing the dKP hierarchy. They form a one-parametric family connected by hodograph-type transformations. Generating equations and Lax-Sato equations are introduced, and a dressing scheme based on the vector nonlinear Riemann problem is formulated. The simplest two-component generalization of the dispersionless 2DTL equation is derived, and its differential reduction analogous to the Dunajski interpolating system is presented. A symmetric two-component generalization of the dispersionless elliptic 2DTL equation is also constructed.

More on boundary holographic Witten diagrams

Science.gov (United States)

Sato, Yoshiki

2018-01-01

In this paper we discuss geodesic Witten diagrams in general holographic conformal field theories with boundary or defect. In boundary or defect conformal field theory, two-point functions are nontrivial and can be decomposed into conformal blocks in two distinct ways; ambient channel decomposition and boundary channel decomposition. In our previous work [A. Karch and Y. Sato, J. High Energy Phys. 09 (2017) 121., 10.1007/JHEP09(2017)121] we only consider two-point functions of same operators. We generalize our previous work to a situation where operators in two-point functions are different. We obtain two distinct decomposition for two-point functions of different operators.

List of participants at SIDE IV meeting, Tokyo, 27 November--1 December 2000

Science.gov (United States)

2001-12-01

Mark J Ablowitz, Vsevolod Adler, Mark Alber, Said Belmehdi, Marco Boiti, Claude Brezinski, R Bullough, Y M Chiang, Theodore Chihara, Peter A Clarkson, Robert Conte, Adam Doliwa, Vladimir Dorodnitsyn, Mitsuaki Eguchi, Claire Gilson, Basil Grammaticos, Valeri Gromak, Rod Halburd, Koji Hasegawa, Jarmo Hietarinta, Ryogo Hirota, Xing Biao Hu, M Idzumi, J Inoguchi, Hiroya Ishikara, Mourad Ismail, Shin Isojima, Kenichi Ito, Yoshiaki Itoh, Masashi Iwasaki, Klara Janglajew, Michio Jimbo, Nalini Joshi, Kenji Kajiwara, Saburo Kakei, Masaru Kamata, Satoshi Kamei, Rinat Kashaev, Shingo Kawai, Taeko Kimijima, K Kimura, Anatol Kirillov, Koichi Kondo, Boris Konopelchenko, Martin Kruskal, Atsuo Kuniba, Wataru Kunishima, Franklin Lambert, Serguei Leble, Decio Levi, Shigeru Maeda, Manuel Manas, Ken-Ichi Maruno, Tetsu Masuda, J Matsukidaira, Atsushi Matsumiya, Shigeki Matsutani, Yukitaka Minesaki, Mikio Murata, Micheline Musette, Atsushi Nagai, Katsuya Nakagawa, Atsushi Nakamula, Akira Nakamura, Yoshimasa Nakamura, Frank Nijhoff, J J C Nimmo, Katsuhiro Nishinari, Michitomo Nishizawa, A Nobe, Masatoshi Noumi, Yaeko Ohsaki, Yasuhiro Ohta, Kazuo Okamoto, Alexandre Orlov, Naoki Osada, Flora Pempinelli, Spiro Pyrlis, Reinout Quispel, Orlando Ragnisco, Alfred Ramani, Jean-Pierre Ramis, Andreas Ruffing, Simon Ruijsenaars, Satoru Saito, Noriko Saitoh, Hidetaka Sakai, Paulo Santini, Narimasa Sasa, Ryu Sasaki, Yoshikatsu Sasaki, Junkichi Satsuma, Sergei Sergeev, Nobuhiko Shinzawa, Evgueni Sklyanin, Juris Suris, Norio Suzuki, Yukiko Tagami, Katsuaki Takahashi, Daisuke Takahashi, Tomoyuki Takenawa, Yoshiro Takeyama, K M Tamizhmani, T Tamizhmani, Kouichi Toda, Morikatsu Toda, Tetsuji Tokihiro, Takayuki Tsuchida, Yohei Tsuchiya, Teruhisa Tsuda, Satoru Tsujimoto, Walter Van Assche, Claude Viallet, Luc Vinet, Shinsuke Watanabe, Yoshihida Watanabe, Ralph Willox, Pavel Winternitz, Yasuhiko Yamada, Yuji Yamada, Jin Yoneda, Haruo Yoshida, Katsuhiko Yoshida, Daisuke Yoshihara, Fumitaka Yura, J

'Twenty-five years after Chernobyl accident: Safety for the future'. 2011 National report of Ukraine

International Nuclear Information System (INIS)

Imanaka, Tetsuji; Shindo, Mahito

2016-02-01

This is the Japanese translation of the Ukrainian National Report 'Twenty-five Years after Chernobyl Accident: Safety for the Future', published by the Ministry of Ukraine of Emergencies in 2011 (in Ukrainian and English). This Japanese translation is published as an outcome of the KAKENHI research project on liquidations of Nuclear Disasters in the World (headed by Tetsuji Imanaka), in which Shindo participates, and as a KUR report of the Research Reactor Institute at Kyoto University. The objective of publishing this Japanese translation is to provide basic information on how to overcome the consequences of a large-scale Nuclear Disaster for the wide range of public, including decision-makers and administrative staff. By doing so, this publication aims at invigorating discussions over measures to be applied for overcoming the consequences of the TEPCO Nuclear Disaster (started in 11th March 2011 at Fukushima), and at forming proper schemes to minimise the consequences on current and future generations. The original text of this translation tightly summarised the whole picture of the Chernobyl Nuclear Disaster, which had been the only large-scale Nuclear Disaster until 11th March 2011. More importantly, it describes all sorts of measures and schemes taken in Ukraine from 1986 to 2011 in order to overcome the consequences of the Chernobyl Nuclear Disaster, in a quite well structured manner. In other words, from the contents of this text, Japanese readers are able to learn a lot about the very problems currently facing with. Therefore, I wish many Japanese readers will read this text, and utilise the knowledge written here effectively to overcome the consequences of the TEPCO Nuclear Disaster. (J.P.N.)

Multimediální jazyková podpora DSP v němčině

OpenAIRE

Škůrek, Pavel

2008-01-01

Cílem práce je poskytnout německy hovořícímu studentovi jednoduchý a přehledný seznam pojmů, které se vyskytují v oblasti matematiky, fyziky a číslicového zpracování signálu. Jednotlivé pojmy nejsou nijak složitě vysvětlovány. Většinou je uvedena jen základní definice, co daný výraz znamená, popř. jeho funkce. To znamená, že tuto práci nemůžeme považovat za učebnici, jde pouze o takovou první pomoc pro tápajícího studenta. Práce je rozdělena na 3 databáze. První databáze Mathematik obsahuje v...

Chest physiotherapy in preterm infants with lung diseases

Directory of Open Access Journals (Sweden)

Cota Francesco

2010-09-01

Full Text Available Abstract Background In neonatology the role of chest physiotherapy is still uncertain because of the controversial outcomes. Methods The aim of this study was to test the applicability in preterm infants of 'reflex rolling', from the Vojta method, in preterm neonates with lung pathology, with particular attention to the effects on blood gases and oxygen saturation, on the spontaneous breathing, on the onset of stress or pain. The study included 34 preterm newborns with mean gestational age of 30.5 (1.6 weeks - mean (DS - and birth weight of 1430 (423 g - mean (DS -, who suffered from hyaline membrane disease, under treatment with nasal CPAP (continuous positive airways pressure, or from pneumonia, under treatment with oxygen-therapy. The neonates underwent phase 1 of 'reflex rolling' according to Vojta method three times daily. Respiratory rate, SatO2, transcutaneous PtcCO2 e PtcO2 were monitored; in order to evaluate the onset of stress or pain following the stimulations, the NIPS score and the PIPP score were recorded; cerebral ultrasound scans were performed on postnatal days 1-3-5-7, and then weekly. Results In this population the first phase of Vojta's 'reflex rolling' caused an increase of PtcO2 and SatO2 values. No negative effects on PtcCO2 and respiratory rate were observed, NIPS and PIPP stress scores remained unmodified during the treatment; in no patient the intraventricular haemorrhage worsened in time and none of the infants developed periventricular leucomalacia. Conclusions Our experience, using the Vojta method, allows to affirm that this method is safe for preterm neonates, but further investigations are necessary to confirm its positive effects and to evaluate long-term respiratory outcomes.

Marked hypercapnia during cardiopulmonary bypass for myocardial revascularization. Case report.

Science.gov (United States)

Nascimento, Maurício Serrano; Bernardes, Cassiano Franco; de Medeiros, Roberta Louro

2002-04-01

Bypassing heart blood and returning it oxygenated to systemic circulation is achieved at the expenses of major cardiopulmonary physiologic changes. The aim of this report was to present an anesthetic complication during CPB and to warn for the need of interaction of the whole anesthetic-surgical team to prevent adverse perioperative events. A brown female patient, 56 years old, 95 kg, height 1.65 m, physical status ASA IV, with chronic renal failure under hemodialysis was admitted for myocardial revascularization. Monitoring consisted of ECG, invasive blood pressure, pulse oximetry, capnography, esophageal temperature, central venous pressure and anesthetic gases analysis. Patient was premedicated with intravenous midazolam (0.05 mg kg(-1)). Anesthesia was induced with fentanyl (16 microg kg(-1)), etomidate (0.3 mg kg(-1)) and pancuronium (0.1 mg kg(-1)), and was maintained with O2, isoflurane (0.5 - 1 MAC) and fentanyl continuous infusion. Blood gas analysis after induction has shown: pH: 7.41; PaO2: 288 mmHg; PaCO2: 38 mmHg; HCO3: 24 mmol L(-1); BE: 0 mmol L(-1); SatO2 100%. A second blood gases analysis, sampled soon after CPB, returned in 30 minutes, showing: pH 7.15; PaO2: 86 mmHg; PaCO2 224 mmHg; HCO3: 29 mmol L(-1); BE: -3 mmol L(-1); SatO2 99%. Thorough and urgent checking of anesthetic and perfusion equipment was performed and revealed that the gas blender was connected to the O2 line and to a CO2 cylinder, when it should be connected to the compressed air cylinder. Bypass circuit mechanical problems may occur in the intraoperative period, and demand prompt repairs. Technological advances in anesthesia equipment, monitoring and safety standards will lessen the possibility of cases such as this to be repeated, but will never replace anesthesiologists surveillance.

IAEA, Fukushima Prefecture Sign Cooperation Memorandum

International Nuclear Information System (INIS)

2012-01-01

Full text: IAEA Director General Yukiya Amano and the Governor of Fukushima Prefecture, Yuhei Sato, today signed a Memorandum of Cooperation confirming their willingness to implement concrete projects to help alleviate the consequences of the accident at TEPCO's Fukushima Daiichi Nuclear Power Station. The Memorandum, signed on the sidelines of the three-day Fukushima Ministerial Conference on Nuclear Safety, includes arrangements to promote cooperation in two key areas: one on radiation monitoring and remediation between the IAEA and Fukushima Prefecture, and the other on human health between the IAEA and Fukushima Medical University. The Memorandum also highlights plans for a training centre in Fukushima Prefecture to help reinforce emergency preparedness and response activities, supported by the Government of Japan and Fukushima Prefecture. An IAEA Response and Assistance Network (RANET) Capacity Building Centre will be designated, with IAEA radiation monitoring equipment to be deployed in case of need, and to provide training in emergency preparedness and response in Japan and the Asia Pacific region. 'With this framework, the wisdom of the international community as well as the IAEA will be utilised in the process of reconstruction in Fukushima', said Japan's Minister of Foreign Affairs, Koichiro Gemba, who attended the signing ceremony. 'I'm very much encouraged by the conclusion of this Memorandum and I believe this will serve to promote reconstruction in Fukushima', said Governor Sato. 'We will also be able to disseminate to the rest of the world the knowledge and experience to be gained from the activities that we are conducting, and we hope this will be a symbol of Fukushima'. 'The IAEA has expertise in the areas of remediation and decontamination, as well as environmental monitoring and human health'. said Director General Amano. 'It is our hope that we will support Fukushima and at the same time serve as a bridge connecting the Prefecture and the world

Renkoho: Maintaining a Flexible Body for Health & Longevity

Directory of Open Access Journals (Sweden)

Katsumi Murakami

2012-07-01

Full Text Available For nearly sixty years Murakami Katsumi (b. 1927 has been a practitioner of Okinawa Karatedo and martial arts. He also studied Chinese martial arts under Sato Kinbei (b. 1926. Yet despite his advanced years, he still moves like a much younger man, a tribute to his diligence in pursuing martial arts as both a physical, mental, and spiritual discipline. This article is excerpted from his book Karate no Kokoro to Waza (The Spirit and Techniques of Karate and details the exercises he has created to prepare the body for martial art training and extending one’s life through the practice of good health. All the exercises demonstrated in this article are performed by the original author.

Improved Simulation of the Pre-equilibrium Triton Emission in Nuclear Reactions Induced by Nucleons

Science.gov (United States)

Konobeyev, A. Yu.; Fischer, U.; Pereslavtsev, P. E.; Blann, M.

2014-04-01

A new approach is proposed for the calculation of non-equilibrium triton energy distributions in nuclear reactions induced by nucleons of intermediate energies. It combines models describing the nucleon pick-up, the coalescence and the triton knock-out processes. Emission and absorption rates for excited particles are represented by the pre-equilibrium hybrid model. The model of Sato, Iwamoto, Harada is used to describe the nucleon pick-up and the coalescence of nucleons from exciton configurations starting from (2p,1h) states. The contribution of the direct nucleon pick-up is described phenomenologically. Multiple pre-equilibrium emission of tritons is accounted for. The calculated triton energy distributions are compared with available experimental data.

Eigenvalues of the Laplacian and of the Hecke operators for PSL(2,Z)

International Nuclear Information System (INIS)

Steil, G.

1994-03-01

A new method is described to compute with high accuracy a large number of eigenvalues and eigenfunctions (Maass wave forms) of the Laplacian and of the Hecke operators for the modular group. It relies essentially on the theory of Hecke operators. The results of the computations confirm some important conjectures from number theory, namely Ramanujan-Petersson, Sato-Tate, and the conjecture that the discrete spectrum of the Laplacian be simple. Examples of the numerical data are included as a reference. The algorithm can be generalized to other non-cocompact but cofinite arithmetic groups, like Picard group PSL(2, Z)[i]) and Hecke triangle groups Γ(√2) and Γ(√3). (orig.)

Electron capture in pseudo-two-electron systems: Ar8++He

International Nuclear Information System (INIS)

Kimura, M.; Olson, R.E.

1985-01-01

Molecular-structure calculations using the pseudopotential method have been performed on the (ArHe) 8+ system. The cross section for single-electron capture in Ar 8+ +He collisions was calculated for energies from 20 eV to 10 keV/amu. The perturbed-stationary-state method [M. Kimura, H. Sato, and R. E. Olson, Phys. Rev. A 28, 2085 (1983)], modified to include electron translation factors appropriate to two-electron systems, was used. The total cross section is relatively energy independent with a value of approximately 2.5 x 10 -15 cm 2 . The n = 4 level of Ar 7+ is found to be preferentially populated, with the 4f level being dominant

The 100th anniversary of Yukawa and Tomonaga's birth

International Nuclear Information System (INIS)

Sato, Fumitaka; Ukawa, Akira; Takasugi, Eiichi; Kuroda, Yoichiro; Kamefuchi, Susumu; Tanaka, Sho; Kinoshita, Toichiro

2006-01-01

The above feature articles contain seven papers such as 1) contribution of leading figures to innovate physics by Humitaka Sato, 2) half century of quantum field theory and renormalization theory by Akira Ukawa, 3) inheritance from Dr. Yukawa by Eiichi Takasugi, 4) Dr. Tomonaga and 'Science and Technology Square' by Yoichiro Kuroda, 5) a trial to Shin-ichiro Tomonaga theory by Susumu Kamefuchi, 6) Dr. Yukawa and Einstein living the century of war and science by Sho Tanaka, and 7) precision calculation of QED and Tomonaga theory by Toichiro Kinoshita. Extracts from Tomonaga's 'Future of the theory of elementary particles', Yukawa's 'Cost of science researches' and 'An age of theoretical physics' are reported. (S.Y.)

Boundary layer theory approach to the concentration layer adjacent to the ceiling wall of a hydrogen leakage: Axisymmetric impinging and far regions

Energy Technology Data Exchange (ETDEWEB)

El-Amin, M.F.; Kanayama, H. [Department of Mechanical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395 (Japan)

2009-02-15

As hydrogen leaks into a partially open space with a ceiling wall, a boundary layer of hydrogen can be constructed under that wall due to the impingement on the wall and the buoyancy force. The resulting boundary layer can be divided into two regions, namely the stagnation-point region and the far region. When the geometry of the source of the hydrogen leak is circular, such as a pinhole or an o-ring, the behavior of leakage flow will be axisymmetric due to the resulting radial jet. In contrast, when the geometry of the source of the hydrogen leak is planar, such as a crack, the behavior of leakage flow will be planar due to the resulting planar jet. Previously, we studied the planar case in the context of both the stagnation-point flow region [El-Amin MF, Kanayama H. Boundary layer theory approach to the concentration layer adjacent to a ceiling wall at impinging region of a hydrogen leakage. Int J Hydrogen Energy 2008; 33(21): 6393-00] and the far region [El-Amin MF, Inoue M, Kanayama H. Boundary layer theory approach to the concentration layer adjacent to a ceiling wall of a hydrogen leakage: far region. Int J Hydrogen Energy 2008; 33(24):7642-7]. This paper is concerned with both the stagnation-point flow region and the far region of the axisymmetric concentration boundary layer adjacent to a ceiling wall. Flow in the stagnation-point region is treated as Hiemenz flow, while it is treated as Blasius flow in the far region. The current results are compared with the planar cases [El-Amin MF, Kanayama H. Boundary layer theory approach to the concentration layer adjacent to a ceiling wall at impinging region of a hydrogen leakage. Int J Hydrogen Energy 2008; 33(21): 6393-00; El-Amin MF, Inoue M, Kanayama H. Boundary layer theory approach to the concentration layer adjacent to a ceiling wall of a hydrogen leakage: far region. Int J Hydrogen Energy 2008; 33(24):7642-7] for both stagnation-point flow and far regions. Both momentum and concentration boundary layer

The Security of the South Atlantic: Is It a Case for ’SATO’--South Atlantic Treaty Organization

Science.gov (United States)

1982-05-10

p. 704. 21Ibid. 2 2 Ibid. 2 3A.R.A. Nicolas Piccaluga, Control Del Trafico Maritimo en el Atlantic Sud. Politics para la Defensa v Seguridad de las...1981. Piccaluga, A. R. A, Nicolis. Control Del Trafico Maritimo En El Atlantico Sud. Politicar, Para La Defensa Y Seguridad De Las Rutas Maritimas En

Modulation of Spc1 stress-activated protein kinase activity by methylglyoxal through inhibition of protein phosphatase in the fission yeast Schizosaccharomyces pombe

International Nuclear Information System (INIS)

Takatsume, Yoshifumi; Izawa, Shingo; Inoue, Yoshiharu

2007-01-01

Methylglyoxal, a ubiquitous metabolite derived from glycolysis has diverse physiological functions in yeast cells. Previously, we have reported that extracellularly added methylglyoxal activates Spc1, a stress-activated protein kinase (SAPK), in the fission yeast Schizosaccharomyces pombe [Y. Takatsume, S. Izawa, Y. Inoue, J. Biol. Chem. 281 (2006) 9086-9092]. Phosphorylation of Spc1 by treatment with methylglyoxal in S. pombe cells defective in glyoxalase I, an enzyme crucial for the metabolism of methylglyoxal, continues for a longer period than in wild-type cells. Here we show that methylglyoxal inhibits the activity of the protein phosphatase responsible for the dephosphorylation of Spc1 in vitro. In addition, we found that methylglyoxal inhibits human protein tyrosine phosphatase 1B (PTP1B) also. We propose a model for the regulation of the activity of the Spc1-SAPK signaling pathway by methylglyoxal in S. pombe

Vliv obnovitelných zdrojů energie na cenovou volatilitu na evropských trzích s elektřinou

OpenAIRE

Líšková, Katarína

2017-01-01

Integration of renewable energy sources impacts electricity spot price and its variation. Remaining open question is, in which direction. Volatility fluctuations threaten secur- ity of electricity supply, influence trading strategies and create uncertainty in optimal installed capacity planning. In this thesis, drivers of price volatility in Czech and Ger- man day-ahead power market are analysed with an emphasis on penetration of renewable energy sources. To the best of our knowledge, this is...

Theoretical study of short pile effect in tunnel excavation

Science.gov (United States)

Tian, Xiao-yan; Liu, Jing; Gao, Xiao-mei; Li, Yuan

2017-09-01

The Misaki Sato Go ideal elastoplastic model is adopted and the two stage analysis theory is used to study the effect of tunnel excavation on short pile effect in this paper. In the first stage, the free field vertical displacement of the soil at the corresponding pile location is obtained by using empirical formula. In the second stage, the displacement is applied to the corresponding pile location. The equilibrium condition of micro physical differential equation settlement of piles. Then through logical deduction and the boundary condition expressions of the settlement calculation, obtain the pile side friction resistance and axial force of the week. Finally, an engineering example is used to analyze the influence of the change of main parameters on their effects.

Stemcell Information: SKIP000863 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available nese Japanese -- No hiPSC Generation from Peripheral Blood by using non-T medium. 末梢血由来iPS細胞。|T細胞の増殖には関与しない培...a 沖田　圭介 Center for iPS Cell Research and Application, Kyoto University 京都大学iPS細胞研究所 ... Information Only Cen...ter for iPS Cell Research and Application, Kyoto University 京都大学iPS細胞研究所 ... 231...93063 10.1002/stem.1293 An efficient nonviral method to generate integration-free human-induced pluripotent stem cell...s from cord blood and peripheral blood cells. Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Wa

Stemcell Information: SKIP000862 [SKIP Stemcell Database[Archive

Lifescience Database Archive (English)

Full Text Available nese Japanese -- No hiPSC Generation from Peripheral Blood by using non-T medium. 末梢血由来iPS細胞。|T細胞の増殖には関与しない培...suke Okita 沖田　圭介 Center for iPS Cell Research and Application, Kyoto University 京都大学iPS細胞研究所 ... Information... Only Center for iPS Cell Research and Application, Kyoto University 京都大学iPS細胞研究所... ... 23193063 10.1002/stem.1293 An efficient nonviral method to generate integration-free human-induced pluripotent stem cell...s from cord blood and peripheral blood cells. Okita K, Yamakawa T, Matsumura Y, Sato Y, Am

Multiphase layered oxide growth on pure metals. I. General formulation

International Nuclear Information System (INIS)

Fromhold, A.T. Jr.

1982-01-01

A general formulation for the simultaneous growth of any number of layered planar oxide phases on a pure metal under diffusion-controlled conditions has been developed. Four individual situations have been developed in detail, namely, situations in which the predominant mode of ion transport is by cation interstitials, cation vacancies, anion interstitials, or anion vacancies. The generalized formulation enables the determination of quasi-steady-state growth kinetics following step function changes in the experimental conditions such as ambient oxygen pressure or temperature. Numerical evaluation of the coupled growth equations for the individual phases is required to deduce the general predictions of the theory. In the limit of two-layer growth by cation interstitial diffusion, the present formulation reproduces the earlier results of Fromhold and Sato

A nondissipative simulation method for the drift kinetic equation

International Nuclear Information System (INIS)

Watanabe, Tomo-Hiko; Sugama, Hideo; Sato, Tetsuya

2001-07-01

With the aim to study the ion temperature gradient (ITG) driven turbulence, a nondissipative kinetic simulation scheme is developed and comprehensively benchmarked. The new simulation method preserving the time-reversibility of basic kinetic equations can successfully reproduce the analytical solutions of asymmetric three-mode ITG equations which are extended to provide a more general reference for benchmarking than the previous work [T.-H. Watanabe, H. Sugama, and T. Sato: Phys. Plasmas 7 (2000) 984]. It is also applied to a dissipative three-mode system, and shows a good agreement with the analytical solution. The nondissipative simulation result of the ITG turbulence accurately satisfies the entropy balance equation. Usefulness of the nondissipative method for the drift kinetic simulations is confirmed in comparisons with other dissipative schemes. (author)

Compact complex surfaces with geometric structures related to split quaternions

International Nuclear Information System (INIS)

Davidov, Johann; Grantcharov, Gueo; Mushkarov, Oleg; Yotov, Miroslav

2012-01-01

We study the problem of existence of geometric structures on compact complex surfaces that are related to split quaternions. These structures, called para-hypercomplex, para-hyperhermitian and para-hyperkähler, are analogs of the hypercomplex, hyperhermitian and hyperkähler structures in the definite case. We show that a compact 4-manifold carries a para-hyperkähler structure iff it has a metric of split signature together with two parallel, null, orthogonal, pointwise linearly independent vector fields. Every compact complex surface admitting a para-hyperhermitian structure has vanishing first Chern class and we show that, unlike the definite case, many of these surfaces carry infinite-dimensional families of such structures. We provide also compact examples of complex surfaces with para-hyperhermitian structures which are not locally conformally para-hyperkähler. Finally, we discuss the problem of non-existence of para-hyperhermitian structures on Inoue surfaces of type S 0 and provide a list of compact complex surfaces which could carry para-hypercomplex structures.

NOVÉ NA STARÉ – Brno, nároží Bratislavská - Stará

OpenAIRE

Červinková, Kateřina

2014-01-01

Řešené území se nachází v městské části Brno-střed, na nárožní poloze ulic Bratislavská a Stará. Je tvořeno několika parcelami, které jsou v současné době nezastaveny, nebo se na nich nachází stavby dočasného charakteru. Část vymezeného území dnes slouží jako parkoviště Policie České republiky. Od historického centra ji dělí dopravní - malý městský okruh vedoucí ulicí Koliště. V blízkosti řešeného území jsou městské domy většinou s obchodním parterem, postavené v rozmezí konce 19. - 1.pol. 20...

Assessment of void fraction prediction using the RETRAN-3d and CORETRAN-01/VIPRE-02 codes

International Nuclear Information System (INIS)

Aounallah, Y.; Coddington, P.; Gantner, U.

2000-01-01

A review of wide-range void fraction correlations against an extensive database has been undertaken to identify the correlations best suited for nuclear safety applications. Only those based on the drift-flux model have been considered. The survey confirmed the application range of the Chexal-Lellouche correlation, and the database was also used to obtain new parameters for the Inoue drift-flux correlation, which was also found suitable. A void fraction validation study has also been undertaken for the codes RETRAN-3D and CORETRAN-01/VIPRE-02 at the assembly and sub-assembly levels. The study showed the impact of the RETRAN-03 user options on the predicted void fraction, and the RETRAN-3D limitation at very low fluid velocity. At the sub-assembly level, CORETRAN-01/VIPRE-02 substantially underestimates the void in regions with low power-to-flow ratios. Otherwise, a generally good predictive performance was obtained with both RETRAN-3D and CORETRAN-01/VIPRE-02. (authors)

Assessment of void fraction prediction using the RETRAN-3d and CORETRAN-01/VIPRE-02 codes

Energy Technology Data Exchange (ETDEWEB)

Aounallah, Y.; Coddington, P.; Gantner, U

2000-07-01

A review of wide-range void fraction correlations against an extensive database has been undertaken to identify the correlations best suited for nuclear safety applications. Only those based on the drift-flux model have been considered. The survey confirmed the application range of the Chexal-Lellouche correlation, and the database was also used to obtain new parameters for the Inoue drift-flux correlation, which was also found suitable. A void fraction validation study has also been undertaken for the codes RETRAN-3D and CORETRAN-01/VIPRE-02 at the assembly and sub-assembly levels. The study showed the impact of the RETRAN-03 user options on the predicted void fraction, and the RETRAN-3D limitation at very low fluid velocity. At the sub-assembly level, CORETRAN-01/VIPRE-02 substantially underestimates the void in regions with low power-to-flow ratios. Otherwise, a generally good predictive performance was obtained with both RETRAN-3D and CORETRAN-01/VIPRE-02. (authors)

IUTAM Symposium

CERN Document Server

Shioiri, Jumpei

1996-01-01

The IUTAM Symposium on Constitutive Relation in High/Very High Strain Rates (CRHVHSR) was held October 16 - 19, 1995, at Seminar House, Science University of Tokyo, under the sponsorship of IUTAM, Japan Society for the Promotion of Science, The Commemorative Association for the Japan World Exposition (1970), Inoue Foundation for Science, The Japan Society for Aeronautical and Space Sciences, and Science University of Tokyo. The proposal to hold the symposium was accepted by the General Assembly of IUT AM held in Haifa, Israel, in August 1992, and the scientists mentioned below were appointed by the Bureau of IUTAM to serve as members of the Scientific Committee. The main object of the symposium was to make a general survey of recent developments in the research of constitutive relations in high and very high strain rates and related problems in high velocity solid mechanics, and to explore further new ideas for dealing with unresolved problems of a fundamental nature as well as of practical importance. The su...

Nivolumab in the treatment of malignant melanoma: review of the literature

Directory of Open Access Journals (Sweden)

Mashima E

2015-08-01

Full Text Available Emi Mashima, Akiha Inoue, Yumiko Sakuragi, Takashi Yamaguchi, Natsuko Sasaki, Yoko Hara, Daisuke Omoto, Shun Ohmori, Sanehito Haruyama, Yu Sawada, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan Abstract: Nivolumab was developed as a monoclonal antibody against programmed death receptor-1, an immune checkpoint inhibitor which negatively regulates T-cell proliferation and activation. Intravenous administration of nivolumab was approved for the treatment of unresectable malignant melanoma in 2014 in Japan. When advanced melanoma patients were treated with nivolumab, median overall survival became longer. Overall survival rate was significantly better in nivolumab-treated melanoma patients than dacarbazine-treated melanoma patients. Nivolumab had an acceptable long-term tolerability profile, with 22% of patients experiencing grade 3 or 4 adverse events related to the drug. Therefore, nivolumab can become an alternative therapy for advanced malignant melanoma. Keywords: monoclonal antibody, PD-1, PD-L1

Band gaps in periodically magnetized homogeneous anisotropic media

Science.gov (United States)

Merzlikin, A. M.; Levy, M.; Vinogradov, A. P.; Wu, Z.; Jalali, A. A.

2010-11-01

In [A. M. Merzlikin, A. P. Vinogradov, A. V. Dorofeenko, M. Inoue, M. Levy, A. B. Granovsky, Physica B 394 (2007) 277] it is shown that in anisotropic magnetophotonic crystal made of anisotropic dielectric layers and isotropic magneto-optical layers the magnetization leads to formation of additional band gaps (BG) inside the Brillouin zones. Due to the weakness of the magneto-optical effects the width of these BG is much smaller than that of usual BG forming on the boundaries of Brillouin zones. In the present communication we show that though the anisotropy suppresses magneto-optical effects. An anisotropic magnetophotonic crystal made of anisotropic dielectric layers and anisotropic magneto-optical; the width of additional BG may be much greater than the width of the usual Brillouin BG. Anisotropy tends to suppress Brillouin zone boundary band gap formation because the anisotropy suppresses magneto-optical properties, while degenerate band gap formation occurs around points of effective isotropy and is not suppressed.

June 2014 Phoenix pulmonary journal club: new therapies for IPF and EBUS for sardoidosis

Directory of Open Access Journals (Sweden)

Mathew M

2014-06-01

Full Text Available No abstract available. Article truncated at 150 words. Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, Kim DS, Kolb M, Nicholson AG, Noble PW, Selman M, Taniguchi H, Brun M, Le Maulf F, Girard M, Stowasser S, Schlenker-Herceg R, Disse B, Collard HR; INPULSIS Trial Investigators. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22:2071-82. Nintedanib is a tyrosine kinase inhibitor that has been shown to decrease the decline of FVC in phase 2 trials of idiopathic pulmonary fibrosis (IPF. This study was a phase 3 trial in which 2 replicate trials comparing nintedanib 150 mg twice daily to placebo. The trials were randomized double blind placebo controlled performed over 205 sites in 24 countries. Inclusion criteria were an age > 40, FVC > 50% and DLCO 30-79%. Patients were excluded if on prednisone > 15 mg/day or any other ...

JENIS LEBAH TRIGONA (APIDAE: MELIPONINAE PADA KETINGGIAN TEMPAT BERBEDA DI BALI

Directory of Open Access Journals (Sweden)

Niko Susanto Putra

2016-04-01

Full Text Available The aim of this study was to determine the of trigona species (stingless bee live in different altitude in Bali. Samples were collected using purposive sampling technique, following earlier field observations to determine the location of the colonies. Samples were collected from three different locations, those were at Mawang and Taro Village at Gianyar Regency with the altitude of 750,87 m asl. Tua Village in Tabanan Regency with the altitude of 493,007 m asl, and Ngis Village in Karangase Regency with the altitude of 166,18 m asl, Species identifications were based on the morphological characters of nest entrance, the coloration of the body, wing venations, and the structure of bristle of hind tibia. Species identification were referred to Michener (2007, Schwarz (1939, Sakagami (1979, Sakagami and Inoue (1985, and Rassmusen and Cameron (2010. The result shows that out of 13 colonies collected from different altitude, ony 1 species was identified that was Trigona laeviceps. Keywords: Altitude, nest entrance, morphology, Trigona laeviceps

Clinical results of Trabectome surgery for open-angle glaucoma

Directory of Open Access Journals (Sweden)

Mizoguchi T

2015-10-01

Full Text Available Takanori Mizoguchi,1 Shiro Nishigaki,2 Tomoki Sato,3 Harumi Wakiyama,4 Nobuchika Ogino2 1Mizoguchi Eye Clinic, Ophthalmology, Sasebo, 2Nishigaki Eye Clinic, Ophthalmology, Nagoya, 3Sato Eye Clinic, Ophthalmology, Arao, 4Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan Background: The purpose of this study was to determine outcomes when using Trabectome surgery and to evaluate factors associated with its effects in primary open-angle glaucoma (POAG and exfoliation glaucoma (EXG. Methods: This was a prospective, non-randomized, observational, comparative cohort study in which Trabectome surgery was used alone in patients with POAG or EXG. Trabectome surgery was considered to have failed when at least one of the following three criteria was fulfilled: intraocular pressure (IOP ≥21 mmHg and a <20% reduction below the baseline IOP on two consecutive follow-up visits 3 months or more after surgery; need for additional glaucoma surgery; and an increase in number of medications compared with baseline. Results: The subjects were 32 males (34 eyes and 46 females (48 eyes. POAG was observed in 43 eyes and EXG in 39 eyes. IOP after Trabectome surgery decreased significantly from 22.3±6.8 mmHg at baseline to 14.0±3.9 mmHg (23.0% reduction at month 24 in all cases (P<0.0000. The success rate at 2 years was 51.2% for all cases (POAG, 50.9%; EXG, 49.2%. There was no significant difference in success rate between POAG and EXG (P=0.91. Preoperative IOP (P=0.033 and number of medications (P=0.041 were significant factors for surgical success/failure in multivariate logistic regression. No serious complications were observed. Conclusion: Trabectome surgery achieved favorable IOP control and was equally effective in patients with POAG and those with EXG. Its effects were influenced by preoperative IOP and number of preoperative medications. Keywords: Trabectome, primary open-angle glaucoma, exfoliation glaucoma, success rate, risk factors 

Trends in study design and the statistical methods employed in a leading general medicine journal.

Science.gov (United States)

Gosho, M; Sato, Y; Nagashima, K; Takahashi, S

2018-02-01

Study design and statistical methods have become core components of medical research, and the methodology has become more multifaceted and complicated over time. The study of the comprehensive details and current trends of study design and statistical methods is required to support the future implementation of well-planned clinical studies providing information about evidence-based medicine. Our purpose was to illustrate study design and statistical methods employed in recent medical literature. This was an extension study of Sato et al. (N Engl J Med 2017; 376: 1086-1087), which reviewed 238 articles published in 2015 in the New England Journal of Medicine (NEJM) and briefly summarized the statistical methods employed in NEJM. Using the same database, we performed a new investigation of the detailed trends in study design and individual statistical methods that were not reported in the Sato study. Due to the CONSORT statement, prespecification and justification of sample size are obligatory in planning intervention studies. Although standard survival methods (eg Kaplan-Meier estimator and Cox regression model) were most frequently applied, the Gray test and Fine-Gray proportional hazard model for considering competing risks were sometimes used for a more valid statistical inference. With respect to handling missing data, model-based methods, which are valid for missing-at-random data, were more frequently used than single imputation methods. These methods are not recommended as a primary analysis, but they have been applied in many clinical trials. Group sequential design with interim analyses was one of the standard designs, and novel design, such as adaptive dose selection and sample size re-estimation, was sometimes employed in NEJM. Model-based approaches for handling missing data should replace single imputation methods for primary analysis in the light of the information found in some publications. Use of adaptive design with interim analyses is increasing

Stability of elongated cross-section tokamaks to axisymmetric even poloidal mode number deformations

International Nuclear Information System (INIS)

Weiner, R.; Jardin, S.C.; Pomphrey, N.

1989-06-01

A recent paper by Nakayama, Sato and Matsuoka suggests that elliptical cross section tokamaks with aspect ratio R/a = 3.2 and with elongation κ = 2.6 are unstable to a splitting (m = 2, n = 0) instability for plasma β > 5%, and that κ /> =/ 4.0 plasmas are unstable to splitting for β /> =/ 1%. We have tried to reproduce these results using the MHD evolution code TSC, but find these configurations to be stable, not even near a stability boundary. Even a κ = 3.7 plasma with β = 23.0% is stable to the splitting mode. However, the addition of pinching coils at the waist will cause the plasma to split if the current in these coils exceeds a critical value I/sub c/ which decreases with increasing β. 8 refs., 11 figs., 1 tab

PREFACE: International Workshop on Statistical-Mechanical Informatics 2008 (IW-SMI 2008)

Science.gov (United States)

Hayashi, Masahito; Inoue, Jun-ichi; Kabashima, Yoshiyuki; Tanaka, Kazuyuki

2009-01-01

as well as all the participants, who have enjoyed the workshop as well as their stay in Sendai, one of the most beautiful cities in Japan. This successful workshop will stimulate further development of the interdisciplinary research field of QIT and SMI. Masahito Hayashi, Jun-ichi Inoue, Yoshiyuki Kabashima and Kazuyuki Tanaka Editors The IW-SMI 2008 Organizing Committee Kazuyuki Tanaka, General Chair (Tohoku University) Yoshiyuki Kabashima, Vice-General Chair (Tokyo Institute of Technology) Jun-ichi Inoue, Program Chair (Hokkaido University) Masahito Hayashi, Pulications Chair (Tohoku University) Hidetoshi Nishimori (Tokyo Institute of Technology) Toshiyuki Tanaka (Kyoto University)

Molecular dynamics simulation investigations of H2/D2 dissocitive chemisorption dynamics on Cun(n=13-14) Rigid/nonrigid clusters

International Nuclear Information System (INIS)

Elzein, N.

2004-01-01

In this work with a use of molecular dynamic simulations we have reported the results of a quasiclassical simulation study of the interaction of H2/(D2) with Cu N (N=13-14) atoms in both rigid /(non rigid) clusters.The geometry of the cluster is obtained by an embedded-atom (EA) mode potential, and the interaction between the molecule and cIuster is described by a LEPS -London-Eyring -Polanyi-Sato) potential energy function.Both channels the reactive dissociative adsorption of the molecule on the cIuster) and non reactive (scattering of the molecule from the cluster) are considered. The dissociative chemisorption probability, cross section and rate constant are studied as functions of the initial quantal rovibrational state of the molecule, collision energy, impact parameter and the temperature (OK,296K,834K ,1014K,1554K) of the clusters

Explorations of the extended ncKP hierarchy

International Nuclear Information System (INIS)

Dimakis, Aristophanes; Mueller-Hoissen, Folkert

2004-01-01

A recently obtained extension (xncKP) of the Moyal-deformed KP hierarchy (ncKP hierarchy) by a set of evolution equations in the Moyal-deformation parameters is further explored. Formulae are derived to compute these equations efficiently. Reductions of the xncKP hierarchy are treated, in particular to the extended ncKdV and ncBoussinesq hierarchies. Furthermore, a good part of the Sato formalism for the KP hierarchy is carried over to the generalized framework. In particular, the well-known bilinear identity theorem for the KP hierarchy, expressed in terms of the (formal) Baker-Akhiezer function, extends to the xncKP hierarchy. Moreover, it is demonstrated that N-soliton solutions of the ncKP equation are also solutions of the first few deformation equations. This is shown to be related to the existence of certain families of algebraic identities

Relationship between Magnetic Anisotropy below Pseudogap Temperature and Short-Range Antiferromagnetic Order in High-Temperature Cuprate Superconductor

Science.gov (United States)

Morinari, Takao

2018-06-01

The central issue in high-temperature cuprate superconductors is the pseudogap state appearing below the pseudogap temperature T*, which is well above the superconducting transition temperature. In this study, we theoretically investigate the rapid increase of the magnetic anisotropy below the pseudogap temperature detected by the recent torque-magnetometry measurements on YBa2Cu3Oy [Y. Sato et al., 10.1038/nphys4205" xlink:type="simple">Nat. Phys. 13, 1074 (2017)]. Applying the spin Green's function formalism including the Dzyaloshinskii-Moriya interaction arising from the buckling of the CuO2 plane, we obtain results that are in good agreement with the experiment and find a scaling relationship. Our analysis suggests that the characteristic temperature associated with the magnetic anisotropy, which coincides with T*, is not a phase transition temperature but a crossover temperature associated with the short-range antiferromagnetic order.

Is guava phenolic metabolism influenced by elevated atmospheric CO2?

Science.gov (United States)

Mendes de Rezende, Fernanda; Pereira de Souza, Amanda; Silveira Buckeridge, Marcos; Maria Furlan, Cláudia

2015-01-01

Seedlings of Psidium guajava cv. Pedro Sato were distributed into four open-top chambers: two with ambient CO(2) (∼390 ppm) and two with elevated CO(2) (∼780 ppm). Monthly, five individuals of each chamber were collected, separated into root, stem and leaves and immediately frozen in liquid nitrogen. Chemical parameters were analyzed to investigate how guava invests the surplus carbon. For all classes of phenolic compounds analyzed only tannins showed significant increase in plants at elevated CO(2) after 90 days. There was no significant difference in dry biomass, but the leaves showed high accumulation of starch under elevated CO(2). Results suggest that elevated CO(2) seems to be favorable to seedlings of P. guajava, due to accumulation of starch and tannins, the latter being an important anti-herbivore substance. Copyright © 2014 Elsevier Ltd. All rights reserved.

The Nash Equilibrium Revisited: Chaos and Complexity Hidden in Simplicity

Science.gov (United States)

Fellman, Philip V.

The Nash Equilibrium is a much discussed, deceptively complex, method for the analysis of non-cooperative games (McLennan and Berg, 2005). If one reads many of the commonly available definitions the description of the Nash Equilibrium is deceptively simple in appearance. Modern research has discovered a number of new and important complex properties of the Nash Equilibrium, some of which remain as contemporary conundrums of extraordinary difficulty and complexity (Quint and Shubik, 1997). Among the recently discovered features which the Nash Equilibrium exhibits under various conditions are heteroclinic Hamiltonian dynamics, a very complex asymptotic structure in the context of two-player bi-matrix games and a number of computationally complex or computationally intractable features in other settings (Sato, Akiyama and Farmer, 2002). This paper reviews those findings and then suggests how they may inform various market prediction strategies.

Current Status of Peroral Endoscopic Myotomy

Science.gov (United States)

Cho, Young Kwan; Kim, Seong Hwan

2018-01-01

Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders. PMID:29397656

Peroral endoscopic myotomy (POEM) for treating esophageal motility disorders

Science.gov (United States)

Wong, Ian

2017-01-01

Pneumatic dilatation and Heller myotomy have been thoroughly studied as the most viable treatment options for achalasia. The pendulum, however, is shifting to the minimally invasive approach. Since Inoue et al. published the experience of the first 17 cases of peroral endoscopic myotomy (POEM) in 2010, there have been at least 5,000 cases performed worldwide and the number is increasing exponentially. Experts across the globe have been extending the indications to various esophageal motility disorders, to patients of extremes of age, sigmoidal esophagus and re-operated patients. There are a few variations in technique across different centers in defining the gastroesophageal junction (GEJ) and adequacy of myotomy, the optimal length, site of myotomy and whether the full thickness of the muscle wall should be cut. Large case series demonstrated its promising efficacy & reasonable complication profile. Randomized controlled trial in comparison with the gold standard, Heller myotomy, is ongoing. The future application of submucosal tunnelling technique is thrilling with its extension in tumour resection, antropyloromyotomy and other natural orifice transluminal endoscopic surgery (NOTES). PMID:28616407

Current Status of Peroral Endoscopic Myotomy.

Science.gov (United States)

Cho, Young Kwan; Kim, Seong Hwan

2018-01-01

Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders.

Current Status of Peroral Endoscopic Myotomy

Directory of Open Access Journals (Sweden)

Young Kwan Cho

2018-01-01

Full Text Available Peroral endoscopic myotomy (POEM has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders.

Multi-species time-history measurements during high-temperature acetone and 2-butanone pyrolysis

KAUST Repository

Lam, Kingyiu

2013-01-01

High-temperature acetone and 2-butanone pyrolysis studies were conducted behind reflected shock waves using five species time-history measurements (ketone, CO, CH3, CH4 and C2H4). Experimental conditions covered temperatures of 1100-1600 Kat 1.6 atm, for mixtures of 0.25-1.5% ketone in argon. During acetone pyrolysis, the CO concentration time-history was found to be strongly sensitive to the acetone dissociation rate constant κ1 (CH3COCH3 → CH3 + CH3CO), and this could be directly determined from the CO time-histories, yielding κ1(1.6 atm) = 2.46 × 1014 exp(-69.3 [kcal/mol]/RT) s-1 with an uncertainty of ±25%. This rate constant is in good agreement with previous shock tube studies from Sato and Hidaka (2000) [3] and Saxena et al. (2009) [4] (within 30%) at temperatures above 1450 K, but is at least three times faster than the evaluation from Sato and Hidaka at temperatures below 1250 K. Using this revised κ1 value with the recent mechanism of Pichon et al. (2009) [5], the simulated profiles during acetone pyrolysis show excellent agreement with all five species time-history measurements. Similarly, the overall 2-butanone decomposition rate constant κtot was inferred from measured 2-butanone time-histories, yielding κ tot(1.5 atm) = 6.08 × 1013 exp(-63.1 [kcal/mol]/RT) s -1 with an uncertainty of ±35%. This rate constant is approximately 30% faster than that proposed by Serinyel et al. (2010) [11] at 1119 K, and approximately 100% faster at 1412 K. Using the measured 2-butanone and CO time-histories and an O-atom balance analysis, a missing removal pathway for methyl ketene was identified. The rate constant for the decomposition of methyl ketene was assumed to be the same as the value for the ketene decomposition reaction. Using the revised κtot value and adding the methyl ketene decomposition reaction to the Serinyel et al. mechanism, the simulated profiles during 2-butanone pyrolysis show good agreement with the measurements for all five species. �

Field observations of the electrostatic charges of blowing snow in Hokkaido, Japan

Science.gov (United States)

Omiya, S.; Sato, A.

2011-12-01

An electrostatic charge of blowing snow may be a contributing factor in the formation of a snow drift and a snow cornice, and changing of the trajectory of own motion. However, detailed electrification characteristics of blowing snow are not known as there are few reports of charge measurements. We carried out field observations of the electrostatic charges of blowing snow in Tobetsu, Hokkaido, Japan in the mid winter of 2011. An anemovane and a thermohygrometer were used for the meteorological observation. Charge-to-mass ratios of blowing snow were obtained by a Faraday-cage, an electrometer and an electric balance. In this observation period, the air temperature during the blowing snow event was -6.5 to -0.5 degree Celsius. The measured charges in this observation were consistent with the previous studies in sign, which is negative, but they were smaller than the previous one. In most cases, the measured values increased with the temperature decrease, which corresponds with previous studies. However, some results contradicted the tendency, and the maximum value was obtained on the day of the highest air temperature of -0.5 degree Celsius. This discrepancy may be explained from the difference of the snow surface condition on observation day. The day when the maximum value was obtained, the snow surface was covered with old snow, and hard. On the other hand, in many other cases, the snow surface was covered with the fresh snow, and soft. Blowing snow particles on the hard surface can travel longer distance than on the soft one. Therefore, it can be surmised that the hard surface makes the blowing snow particles accumulate a lot of negative charges due to a large number of collisions to the surface. This can be supported by the results of the wind tunnel experiments by Omiya and Sato (2011). By this field observation, it was newly suggested that the electrostatic charge of blowing snow are influenced greatly by the difference of the snow surface condition. REFERENCE

Phenomenological model for non-equilibrium deuteron emission in nucleon induced reactions

International Nuclear Information System (INIS)

Broeders, C.H.M.; Konobeyev, A.Yu.

2005-01-01

A new approach is proposed for the calculation of non-equilibrium deuteron energy distributions in nuclear reactions induced by nucleons of intermediate energies. It combines the model of the nucleon pick-up, the coalescence and the deuteron knock-out. Emission and absorption rates for excited particles are described by the pre-equilibrium hybrid model. The model of Sato, Iwamoto, Harada is used to describe the nucleon pick-up and the coalescence of nucleons from the exciton configurations starting from (2p, 1h). The model of deuteron knock-out is formulated taking into account the Pauli principle for the nucleon-deuteron interaction inside a nucleus. The contribution of the direct nucleon pick-up is described phenomenologically. The multiple pre-equilibrium emission of particles is taken into account. The calculated deuteron energy distributions are compared with experimental data from 12 C to 209 Bi. (orig.)

Hipercapnia acentuada durante circulação extracorpórea em cirurgia para revascularização do miocárdio: relato de caso Hipercapnia acentuada durante circulación extracorpórea en cirugía para revascularización del miocárdio: relato de caso Marked hypercapnia during cardiopulmonary bypass for myocardial revascularization: case report

Directory of Open Access Journals (Sweden)

Maurício Serrano Nascimento

2002-04-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: A função primordial de desviar o sangue do coração e retorná-lo oxigenado à circulação sistêmica é conseguida às custas de importantes alterações na fisiologia cardiopulmonar. O objetivo deste relato é apresentar uma complicação anestésica que ocorreu durante a CEC e alertar para a necessidade da interação de toda a equipe anestésico-cirúrgica na prevenção de eventos adversos per-operatórios. RELATO DO CASO: Paciente feminina, parda, 56 anos, 95 kg, altura 1,65 m, estado físico ASA IV, portadora de insuficiência renal crônica em hemodiálise, foi admitida para realização de revascularização do miocárdio. A monitorização constou de eletrocardiograma (ECG, medida invasiva da pressão arterial, oximetria de pulso, capnografia, temperatura esofágica, pressão venosa central e análise dos gases anestésicos. A paciente recebeu como medicação pré-anestésica, midazolam (0,05 mg.kg-1, por via venosa. Iniciou-se indução venosa com fentanil (16 µg.kg-1, etomidato (0,3 mg.kg-1 e pancurônio (0,1 mg.kg-1. A manutenção foi feita com oxigênio, isoflurano (0,5 - 1 CAM e infusão contínua de fentanil. A gasometria arterial colhida após a indução demonstrou: pH: 7,41; PaO2: 288 mmHg; PaCO2: 38 mmHg; HCO3: 24 mmol.L-1; BE: 0 mmol.L-1; SatO2: 100%. A segunda gasometria arterial, colhida logo após o início da CEC, chegou em 30 minutos e apresentou: pH 7,15; PaO2: 86 mmHg; PaCO2 224 mmHg; HCO3: 29 mmol.L-1; BE: -3 mmol.L-1; SatO2: 99%. Foi feita verificação completa e urgente dos equipamentos anestésicos e de perfusão. Foi constatada conexão do misturador de gases de perfusão (blender à rede de O2 e a um cilindro de dióxido de carbono (CO2, quando deveria estar conectado ao cilindro de ar comprimido. CONCLUSÕES: Falhas mecânicas dos componentes do circuito de extracorpórea podem ocorrer no per-operatório e exigem correções rápidas. Os avanços tecnológicos nos equipamentos

EDITORIAL: Focus on Plasma Medicine

Science.gov (United States)

Morfill, G. E.; Kong, M. G.; Zimmermann, J. L.

2009-11-01

-pressure microwave plasmas in an N2 and O2 gas mixture M K Singh, A Ogino and M Nagatsu Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma H J Lee, C H Shon, Y S Kim, S Kim, G C Kim and M G Kong The acidification of lipid film surfaces by non-thermal DBD at atmospheric pressure in air A Helmke, D Hoffmeister, N Mertens, S Emmert, J Schuette and W Vioel Reduction and degradation of amyloid aggregates by a pulsed radio-frequency cold atmospheric plasma jet D L Bayliss, J L Walsh, G Shama, F Iza and M G Kong The effect of low-temperature plasma on bacteria as observed by repeated AFM imaging René Pompl, Ferdinand Jamitzky, Tetsuji Shimizu, Bernd Steffes, Wolfram Bunk, Hans-Ulrich Schmidt, Matthias Georgi, Katrin Ramrath, Wilhelm Stolz, Robert W Stark, Takuya Urayama, Shuitsu Fujii and Gregor Eugen Morfill Removal and sterilization of biofilms and planktonic bacteria by microwave-induced argon plasma at atmospheric pressure Mi Hee Lee, Bong Joo Park, Soo Chang Jin, Dohyun Kim, Inho Han, Jungsung Kim, Soon O Hyun, Kie-Hyung Chung and Jong-Chul Park Cell permeabilization using a non-thermal plasma M Leduc, D Guay, R L Leask and S Coulombe Physical and biological mechanisms of direct plasma interaction with living tissue Danil Dobrynin, Gregory Fridman, Gary Friedman and Alexander Fridman Nosocomial infections-a new approach towards preventive medicine using plasmas G E Morfill, T Shimizu, B Steffes and H-U Schmidt Generation and transport mechanisms of chemical species by a post-discharge flow for inactivation of bacteria Takehiko Sato, Shiroh Ochiai and Takuya Urayama Low pressure plasma discharges for the sterilization and decontamination of surfaces F Rossi, O Kylián, H Rauscher, M Hasiwa and D Gilliland Contribution of a portable air plasma torch to rapid blood coagulation as a method of preventing bleeding S P Kuo, O Tarasenko, J Chang, S Popovic, C Y Chen, H W Fan, A Scott, M Lahiani, P Alusta, J D Drake and M Nikolic A two

Controlling vortex motion and vortex kinetic friction

International Nuclear Information System (INIS)

Nori, Franco; Savel'ev, Sergey

2006-01-01

We summarize some recent results of vortex motion control and vortex kinetic friction. (1) We describe a device [J.E. Villegas, S. Savel'ev, F. Nori, E.M. Gonzalez, J.V. Anguita, R. Garcia, J.L. Vicent, Science 302 (2003) 1188] that can easily control the motion of flux quanta in a Niobium superconducting film on an array of nanoscale triangular magnets. Even though the input ac current has zero average, the resulting net motion of the vortices can be directed along either one direction, the opposite direction, or producing zero net motion. We also consider layered strongly anisotropic superconductors, with no fixed spatial asymmetry, and show [S. Savel'ev, F. Nori, Nature Materials 1 (2002) 179] how, with asymmetric drives, the ac motion of Josephson and/or pancake vortices can provide a net dc vortex current. (2) In analogy with the standard macroscopic friction, we present [A. Maeda, Y. Inoue, H. Kitano, S. Savel'ev, S. Okayasu, I. Tsukada, F. Nori , Phys. Rev. Lett. 94 (2005) 077001] a comparative study of the friction force felt by vortices in superconductors and charge density waves

Controlling vortex motion and vortex kinetic friction

Science.gov (United States)

Nori, Franco; Savel'ev, Sergey

2006-05-01

We summarize some recent results of vortex motion control and vortex kinetic friction. (1) We describe a device [J.E. Villegas, S. Savel'ev, F. Nori, E.M. Gonzalez, J.V. Anguita, R. Garcìa, J.L. Vicent, Science 302 (2003) 1188] that can easily control the motion of flux quanta in a Niobium superconducting film on an array of nanoscale triangular magnets. Even though the input ac current has zero average, the resulting net motion of the vortices can be directed along either one direction, the opposite direction, or producing zero net motion. We also consider layered strongly anisotropic superconductors, with no fixed spatial asymmetry, and show [S. Savel'ev, F. Nori, Nature Materials 1 (2002) 179] how, with asymmetric drives, the ac motion of Josephson and/or pancake vortices can provide a net dc vortex current. (2) In analogy with the standard macroscopic friction, we present [A. Maeda, Y. Inoue, H. Kitano, S. Savel'ev, S. Okayasu, I. Tsukada, F. Nori , Phys. Rev. Lett. 94 (2005) 077001] a comparative study of the friction force felt by vortices in superconductors and charge density waves.

Glass forming ability: Miedema approach to (Zr, Ti, Hf)-(Cu, Ni) binary and ternary alloys

Energy Technology Data Exchange (ETDEWEB)

Basu, Joysurya [Department of Chemical, Materials and Biomolecular Engineering, 191 Auditorium Road, University of Connecticut, Storrs 06269, CT (United States)], E-mail: jbasu@engr.uconn.edu; Murty, B.S. [Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai 600036 (India); Ranganathan, S. [Department of Materials Engineering, Indian Institute of Science, Bangalore 560012 (India)

2008-10-06

Miedema's approach has been useful in determining the glass forming composition range for a particular alloy system. The concept of mixing enthalpy and mismatch entropy can be used in order to quantify Inoue's criteria of bulk metallic glass formation. In the present study, glass forming composition range has been determined for different binary and ternary (Zr, Ti, Hf)-(Cu, Ni) alloys based on the mixing enthalpy and mismatch entropy calculations. Though copper and nickel appear next to each other in the periodic table, the glass forming ability of the copper and nickel bearing alloys is different. Thermodynamic analysis reveals that the glass forming behaviour of Zr and Hf is similar, whereas it is different from that of Ti. The smaller atomic size of Ti and the difference in the heat of mixing of Ti, Zr, Hf with Cu and Ni leads to the observed changes in the glass forming behaviour. Enthalpy contour plots can be used to distinguish the glass forming compositions on the basis of the increasing negative enthalpy of the composition. This method reveals the high glass forming ability of binary Zr-Cu, Hf-Cu, Hf-Ni systems over a narrow composition range.

Materials for the 21st Century. Can the carbon come from CO{sub 2}

Energy Technology Data Exchange (ETDEWEB)

Kissling, S.; Altenbuchner, P.T.; Rieger, B. [Technische Univ. Muenchen (Germany). WACKER Lehrstuhl fuer Makromolekulare Chemie

2012-07-01

The major amount of synthetic polymers depend on petroleum feedstock. The topic of biodegradable plastics has drawn much attention since the discovery of poly(propylene carbonate) by Inoue, over 40 years ago. Coupling of carbon dioxide with epoxides leads to polycarbonates, which are temperature stable, biodegradable, firm, elastic and highly transparent. These properties open up a wide range of applications. The most preferable epoxide in the copolymerization is propylene oxide. Up to date, there are three different catalyst systems (zinc glutarates, zinc phenoxides and {beta}-diketiminato-zinc-complexes) containing zinc as a metal center. Due to the fact that heterogeneous zinc glutarates show low activities, our work focuses on homogenous catalyst systems. Herein it is a big challenge to avoid the formation of byproducts, namely the back-biting reaction and the consecutive insertion of epoxides. Therefore a catalyst must be designed to suppress these reactions. Furthermore, most of the zinc based catalysts are only active for the copolymerization of CO{sub 2} and cyclohexene oxide and not propylene oxide. The presentation will give a detailed insight into new catalyst structures and especially mechanistic aspects concerned with electronical and sterical influences of the polymerization catalyst. (orig.)

Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase.

Science.gov (United States)

Heck, Julie A; Meng, Xiao; Frick, David N

2009-04-01

Cyclophilins are cellular peptidyl isomerases that have been implicated in regulating hepatitis C virus (HCV) replication. Cyclophilin B (CypB) is a target of cyclosporin A (CsA), an immunosuppressive drug recently shown to suppress HCV replication in cell culture. Watashi et al. recently demonstrated that CypB is important for efficient HCV replication, and proposed that it mediates the anti-HCV effects of CsA through an interaction with NS5B [Watashi K, Ishii N, Hijikata M, Inoue D, Murata T, Miyanari Y, et al. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol Cell 2005;19:111-22]. We examined the effects of purified CypB proteins on the enzymatic activity of NS5B. Recombinant CypB purified from insect cells directly stimulated NS5B-catalyzed RNA synthesis. CypB increased RNA synthesis by NS5B derived from genotype 1a, 1b, and 2a HCV strains. Stimulation appears to arise from an increase in productive RNA binding. NS5B residue Pro540, a previously proposed target of CypB peptidyl-prolyl isomerase activity, is not required for stimulation of RNA synthesis.

A case of mitochondrial cardiomyopathy with restrictive transmitral filling pattern

Directory of Open Access Journals (Sweden)

Otsui K

2012-04-01

Full Text Available Kazunori Otsui, Nobutaka Inoue, Anna Tamagawa, Kazuo OnishiDepartment of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe, JapanAbstract: A 61-year-old diabetic woman with a mitochondrial A3243G mutation was hospitalized for evaluation of breathlessness, general fatigue, and leg edema. Chest radiography revealed cardiomegaly with massive pleural effusion. Serum lactate, pyruvate, and brain natriuretic peptide concentrations were elevated. Transthoracic echocardiography revealed a restrictive pattern of transmitral flow, although systolic function of the left ventricle was only mildly impaired. Based on these findings and her clinical course, the patient was diagnosed with right-sided heart failure caused by mitochondrial cardiomyopathy associated with a restrictive transmitral filling pattern. Treatment with furosemide, enalapril, and eplerenone was effective, and improvement in her symptoms was associated with amelioration of transthoracic echocardiographic findings and a reduction in serum brain natriuretic peptide levels. Previous reports have indicated heterogeneity in the clinical features of mitochondrial cardiomyopathy in patients carrying the A3243G mutation; the present case highlights the substantial variability in the clinical features of this disease.Keywords: mitochondrial disease, A3243G mutation, diastolic dysfunction, transmitral flow

Bubble growth in a narrow horizontal space

International Nuclear Information System (INIS)

Stutz, Benoit; Goulet, Remi; Passos, Julio Cesar

2009-01-01

The purpose of this work is to develop an axis-symmetric two-phase flow model describing the growth of a single bubble squeezed between a horizontal heated upward-facing disc and an insulating surface placed parallel to the heated surface. Heat transfers at the liquid-vapour interfaces are predicted by the kinetic limit of vaporisation. The depths of the liquid films deposed on the surfaces (heated surface and confinement space) are determined using the Moriyama and Inoue correlation (1996). Transient heat transfers within the heated wall are taken into account. The model is applied to pentane bubble growth. The influence of the gap size, the initial temperature of the system, the thermal effusivity of the heated wall and the kinetic limit of vaporisation are studied. The results show that the expansion of the bubbles strongly depends on the gap size and can be affected by the effusivity of the material. Mechanical inertia effects are mainly dominant at the beginning of the bubble expansion. Pressure drop induced by viscous effects have to be taken into account for high capillary numbers. Heat transfers at the meniscus are negligible except at the early stages of the bubble growth. (author)

A de novo microdeletion involving PAFAH1B (LIS1 related to lissencephaly phenotype

Directory of Open Access Journals (Sweden)

Keiko Shimojima

2015-09-01

Full Text Available Lissencephaly is a type of the congenital malformation of the brain. Due to the impairments of neuronal migration, patients show absence of brain convolution manifesting smooth brain surfaces. One of the human genes responsible for lissencephaly is the platelet-activating factor acetylhydrolase 1b gene (PAFAH1B; also known as LIS1 located on 17p13.3. Patients with heterozygous deletion of this chromosomal region exhibit lissencephaly. Recently, we encountered a male patient who showed typical lissencephaly. Using a microarray analysis, we identified a 1.3 Mb submicroscopic deletion in 17p13.3. This deletion included PAFAH1B. Both of the parents showed no deletion in this region. Therefore, this was determined to be derived from de novo origin. After obtaining the written informed consent, skin fibroblasts were provided from this patient and disease-specific induced pluripotent stem (iPS cells were generated and used for medical research (Shimojima K, Okumura A, Hayashi M, Kondo T, Inoue H, and Yamamoto T. CHCHD2 is down-regulated in neuronal cells differentiated from iPS cells derived from patients with lissencephaly. Genomics, in press.

Bubble growth in a narrow horizontal space

Energy Technology Data Exchange (ETDEWEB)

Stutz, Benoit; Goulet, Remi [CETHIL, UMR5008, CNRS, INSA-Lyon, Universite Lyon1 (France); Passos, Julio Cesar [Universidade Federal de Santa Catarina (UFSC), Florianopolis, SC (Brazil). Dept. de Engenharia Mecanica. LABSOLAR

2009-07-01

The purpose of this work is to develop an axis-symmetric two-phase flow model describing the growth of a single bubble squeezed between a horizontal heated upward-facing disc and an insulating surface placed parallel to the heated surface. Heat transfers at the liquid-vapour interfaces are predicted by the kinetic limit of vaporisation. The depths of the liquid films deposed on the surfaces (heated surface and confinement space) are determined using the Moriyama and Inoue correlation (1996). Transient heat transfers within the heated wall are taken into account. The model is applied to pentane bubble growth. The influence of the gap size, the initial temperature of the system, the thermal effusivity of the heated wall and the kinetic limit of vaporisation are studied. The results show that the expansion of the bubbles strongly depends on the gap size and can be affected by the effusivity of the material. Mechanical inertia effects are mainly dominant at the beginning of the bubble expansion. Pressure drop induced by viscous effects have to be taken into account for high capillary numbers. Heat transfers at the meniscus are negligible except at the early stages of the bubble growth. (author)

Investigation of transverse Peltier effect on top-seeded melt textureYBa2Cu3O7-δ

International Nuclear Information System (INIS)

He, Z.H.; Ma, Z.G.; Li, Q.Y.; Luo, Y.Y.; Zhang, J.X.; Meng, R.L.; Chu, C.W.

1996-01-01

The transverse Peltier effect is investigated on the top-seeded melt texture superconductor YBa 2 Cu 3 O 7-δ (YBCO). By restricting the heat absorbing or evolving on one of the sample close-quote s surfaces, the Peltier heat flow is converted into a temperature difference for measurement. The temperature difference is found proportional to the current applied, which is in accordance with the prediction of transverse Peltier effect. Based on a simplified model, the difference of the Seebeck coefficients between the ab plane and the c axis, |S ab -S c |, is about 35 μV/K. It is in good agreement with that of large single crystal [I. Terasaki, Y. Sato, S. Tajima, S. Miyamoto, and S. Tanaka, Physica C 235-240, 1413 (1994)]. The transverse Peltier effect is verified. This supports the idea that the off-diagonal thermoelectric effect is responsible for the anomalously high laser-induced transient transverse voltage on the oriented YBCO superconducting thin films. copyright 1996 American Institute of Physics

Wavelength and intensity dependence of recollision-enhanced multielectron effects in high-order harmonic generation

Science.gov (United States)

Abanador, Paul M.; Mauger, François; Lopata, Kenneth; Gaarde, Mette B.; Schafer, Kenneth J.

2018-04-01

Using a model molecular system (A2) with two active electrons restricted to one dimension, we examine high-order harmonic generation (HHG) enhanced by rescattering. Our results show that even at intensities well below the single ionization saturation, harmonics generated from the cation (A2+ ) can be significantly enhanced due to the rescattering of the electron that is initially ionized. This two-electron effect is manifested by the appearance of a secondary plateau and cutoff in the HHG spectrum, extending beyond the predicted cutoff in the single active electron approximation. We use our molecular model to investigate the wavelength dependence of rescattering enhanced HHG, which was first reported in a model atomic system [I. Tikhomirov, T. Sato, and K. L. Ishikawa, Phys. Rev. Lett. 118, 203202 (2017), 10.1103/PhysRevLett.118.203202]. We demonstrate that the HHG yield in the secondary cutoff is highly sensitive to the available electron rescattering energies as indicated by a dramatic scaling with respect to driving wavelength.

FY 1999 report on the survey of the history/inheritance of industrial technology. Survey of the inheritance/education of technology in museums of industrial technology in Japan; 1999 nendo sangyo gijutsu rekishi keisho chosa hokokusho. Kokunai sangyo gijutsu hakubutsukan ni okeru gijutsu keisho keihatsu chosa hen

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

For the purpose of clarifying the course of promotion of the original/creative future R and D and contributing to selection of technical themes and working-out of developmental methods, survey was conducted paying visits to museums of industrial technology in Japan which evaluate/preserve/exhibit/utilize memorial goods, data, information pertaining to the industrial technology in Japan. Museums for survey were the following ten: Chiba Museum of Science and Industry; Garasu no Sato (Glass Village); Maizuru World Brick Museum; Museum of Industrial Technology; Numata Memorial Hall/Mitsutoyo Museum of Dimensional Metrology; Omachi Energy Museum; Sake Museum; Saint Juan Bautista Museum; Subway Museum; Textile Museum Yukari. One of the points of this survey was to survey the actual state of the experimental type exhibition. The experimental type exhibition, which is wide in sphere, seems to be effective since visitors can operate it, simulate it, feel its size and make scientific experiments. However, the museums are not necessarily satisfied with the present situation. (NEDO)

Review of the clavatus group of the lanternfly genus Pyrops (Hemiptera: Fulgoromorpha: Fulgoridae

Directory of Open Access Journals (Sweden)

Jérôme Constant

2017-03-01

Full Text Available The clavatus group of Pyrops Spinola, 1839 is reviewed and redefined. The new combination Pyrops atroalbus (Distant, 1918 comb. nov. is proposed, as atroalbus is reinstated as a full species from status of subspecies of Pyrops watanabei (Matsumura, 1913. Pyrops nigripennis (Chou & Wang, 1985 and Pyrops clavatus mizunumai (Sato & Nagai, 1994 are proposed as junior synonyms of P. clavatus (Westwood, 1839. The Philippine species P. polillensis (Baker, 1925 is removed from the group and not attributed to any of the currently defined species groups. Hence, the clavatus group is restricted to continental Southeast Asia and Taiwan and contains three species: P. atroalbus comb. nov., P. clavatus and P. watanabei. A key to the species of the group and illustrations of the male genitalia are provided. The intraspecific colour variation in the group is discussed and illustrated. The genus Pyrops is removed from the subfamily Fulgorinae and not attributed to any of the currently defined subfamilies of Fulgoridae.

Non-Abelian integrable hierarchies: matrix biorthogonal polynomials and perturbations

Science.gov (United States)

Ariznabarreta, Gerardo; García-Ardila, Juan C.; Mañas, Manuel; Marcellán, Francisco

2018-05-01

In this paper, Geronimus–Uvarov perturbations for matrix orthogonal polynomials on the real line are studied and then applied to the analysis of non-Abelian integrable hierarchies. The orthogonality is understood in full generality, i.e. in terms of a nondegenerate continuous sesquilinear form, determined by a quasidefinite matrix of bivariate generalized functions with a well-defined support. We derive Christoffel-type formulas that give the perturbed matrix biorthogonal polynomials and their norms in terms of the original ones. The keystone for this finding is the Gauss–Borel factorization of the Gram matrix. Geronimus–Uvarov transformations are considered in the context of the 2D non-Abelian Toda lattice and noncommutative KP hierarchies. The interplay between transformations and integrable flows is discussed. Miwa shifts, τ-ratio matrix functions and Sato formulas are given. Bilinear identities, involving Geronimus–Uvarov transformations, first for the Baker functions, then secondly for the biorthogonal polynomials and its second kind functions, and finally for the τ-ratio matrix functions, are found.

Psychiatric diagnoses in patients with burning mouth syndrome and atypical odontalgia referred from psychiatric to dental facilities

Directory of Open Access Journals (Sweden)

Miho Takenoshita

2010-10-01

Full Text Available Miho Takenoshita1, Tomoko Sato1, Yuichi Kato1, Ayano Katagiri1, Tatsuya Yoshikawa1, Yusuke Sato2, Eisuke Matsushima3, Yoshiyuki Sasaki4, Akira Toyofuku11Psychosomatic Dentistry, 2Complete Denture Prosthodontics, 3Liaison Psychiatry and Palliative Medicine, 4Center for Education and Research in Oral Health Care, Faculty of Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanBackground: Burning mouth syndrome (BMS and atypical odontalgia (AO are two conditions involving chronic oral pain in the absence of any organic cause. Psychiatrically they can both be considered as “somatoform disorder”. From the dental point of view, however, the two disorders are quite distinct. BMS is a burning or stinging sensation in the mouth in association with a normal mucosa whereas AO is most frequently associated with a continuous pain in the teeth or in a tooth socket after extraction in the absence of any identifiable cause. Because of the absence of organic causes, BMS and AO are often regarded as psychogenic conditions, although the relationship between oral pain and psychologic factors is still unclear. Some studies have analyzed the psychiatric diagnoses of patients with chronic oral pain who have been referred from dental facilities to psychiatric facilities. No study to date has investigated patients referred from psychiatric facilities to dental facilities.Objective: To analyze the psychiatric diagnoses of chronic oral pain patients, diagnosed with BMS and AO, and referred from psychiatric facilities to dental facilities.Study design: Psychiatric diagnoses and disease conditions of BMS or AO were investigated in 162 patients by reviewing patients’ medical records and referral forms. Psychiatric diagnoses were categorized according to the International Statistical Classification of Disease and Related Health Problems, Tenth Revision.Results: The proportion of F4 classification (neurotic, stress

Caracterização química do óleo essencial de folhas de goiabeira (Psidium guajava L. e seus efeitos no comportamento da lagarta-do-cartucho do milho Spodoptera frugiperda (J. E. Smith, 1797 (Lepidoptera: Noctuidae Essential oil chemical composition from leaves of guava (Psidium guajava L. and its effects on the fall armyworm Spodoptera frugiperda (J. E. Smith, 1797. (Lepidoptera: Noctuidae behavior

Directory of Open Access Journals (Sweden)

Rafaela Karin Lima

2009-01-01

Full Text Available Nesta pesquisa, objetivou-se a obtenção e caracterização do óleo essencial de folhas da goiabeira Psidium guajava cv. Pedro Sato, e seus possíveis efeitos no comportamento da lagarta-do-cartucho do milho Spodoptera frugiperda. O óleo essencial foi obtido pela técnica "arraste a vapor d'água", utilizando-se de um aparelho de Clevenger modificado e submetido, posteriormente, à análise por cromatografia gasosa acoplada a um espectrômetro de massas CG-EM, a fim de investigar sua composição. Para a avaliação dos efeitos do óleo essencial no comportamento das lagartas de 1º ínstar foram testados quatro tratamentos, dois com o óleo essencial na concentração de 0,01% e 0,001%, diluídos em etanol/água 1:1, e duas testemunhas, uma com água e outra com etanol/água 1:1. Os resultados obtidos mostraram que o óleo essencial de folhas de goiabeira apresenta na sua constituição o α-terpineol (0,9%, 1,8-cineol (7,0%, β-cariofileno (7,2% e o óxido de cariofileno (13,8%. Constatou-se, também, que o óleo essencial demonstrou efeito repelente para a lagarta-do-cartucho na concentração de 0,01%.The aim of this research was to obtain and characterize essential oil from leaves of Psidium guajava cv. Pedro Sato, and its possible effects on fall armyworm Spodoptera frugiperda behavior. The essential oil was obtained through steam distillation, by using a modified Clevenger apparatus, and the chemical composition was later analyzed by gas chromatography coupled to mass spectroscopy GC-MS. In order to evaluate the essential oil effect on the armyworm of 1st instars behavior, four treatments were tested; two with oil at 0.01 and 0.001 % in ethanol/water 1:1 concentration; two controls with water and the other with ethanol/water 1:1. The results showed that the above analyzed essential oil constituted of á-terpineole (0.9%, 1,8-cineole (7.0%, â-caryophyllene (7.2% and the caryophyllene oxide (13.8%. It was also found that the essential

The magnetic properties of amorphous and nanocrystalline cobalt-rare earth films

Science.gov (United States)

Thomas, Richard Allen

Magnetic materials are of great technological importance for their use in transformers, electric motors, computer disks and hard drives, etc. Understanding the intrinsic physical properties of magnetic materials is essential in order to develop new and better materials for these applications. Presented here is a study of the magnetic properties of amorphous and nanocrystalline cobalt-rare earth (Co-R, where R = Y, Pr, Gd, and Dy) films composed of very small crystalline grains, about 2--200 nm in size. The films are produced by co-sputtering two single element targets onto a single substrate. Many are then annealed briefly to produce magnetic films composed of nanoscale crystallites. The magnetic properties of these films depend largely on the relative strengths of the exchange interaction, which tends to align the spins within a group of crystallites, and the magnetocrystalline anisotropy, which tends to align the spins within each crystallite to an easy direction defined by the crystal lattice. The ratio of these two competing interactions varies strongly with grain size as predicted by the random magnetic anisotropy model. The coercivity, remanent magnetization, initial magnetization, etc., are discussed in light of the predictions made by the models of Callen et al (1977), Chi and Alben (1977), Chudnovsky (1986), and Fukunaga and Inoue (1992).

Stochastic Rotation Dynamics simulations of wetting multi-phase flows

Science.gov (United States)

Hiller, Thomas; Sanchez de La Lama, Marta; Brinkmann, Martin

2016-06-01

Multi-color Stochastic Rotation Dynamics (SRDmc) has been introduced by Inoue et al. [1,2] as a particle based simulation method to study the flow of emulsion droplets in non-wetting microchannels. In this work, we extend the multi-color method to also account for different wetting conditions. This is achieved by assigning the color information not only to fluid particles but also to virtual wall particles that are required to enforce proper no-slip boundary conditions. To extend the scope of the original SRDmc algorithm to e.g. immiscible two-phase flow with viscosity contrast we implement an angular momentum conserving scheme (SRD+mc). We perform extensive benchmark simulations to show that a mono-phase SRDmc fluid exhibits bulk properties identical to a standard SRD fluid and that SRDmc fluids are applicable to a wide range of immiscible two-phase flows. To quantify the adhesion of a SRD+mc fluid in contact to the walls we measure the apparent contact angle from sessile droplets in mechanical equilibrium. For a further verification of our wettability implementation we compare the dewetting of a liquid film from a wetting stripe to experimental and numerical studies of interfacial morphologies on chemically structured surfaces.

FY 1997 R/D project of industrial and scientific technologies contracted with NEDO. Report on technology development of utilization of biological resources such as bioconsortia (development of analytical techniques of bioconsortia); 1997 nendo sangyo gijutsu kenkyu kaihatsu jigyo Shin energy Sangyo Gijutsu Sogo Kaihatsu Kiko itaku. Fukugo seibutsukei nado seibutsu shigen riyo gijutsu kaihatsu (fukugo seibutsukei kaiseki gijutsu no kaihatsu) seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-01

Bioconsortia are microbial composites composing of more than two kinds of microorganisms with special functions. To utilize their advanced functions, some techniques have been developed for analyzing their functions and interactions, and for identification, separation and incubation of the constituent microbial groups. In FY 1997, an investigation was made on technology trends, domestic researchers, and research topics related to bioconsortia. To manage and promote the progress of research at the National Institute of Bioscience and Human-Technology where the centralized management of this project is conducted, meetings are held once a month to examine the progress at the institute, in which reports are made and discussions are held on how each research item is progressing. In addition, meetings of the committee to promote research are held every other month to consider and examine measures required for promoting the research. Re-entrustment of research has been made on two subjects, i.e., `Studies on biological significance of symbiotic microorganisms` by Prof. Ishikawa of the University of Tokyo, and `Study on the relationship between the biosynthesis of useful terpenic materials of plant origin and the differentiation of plant tissues, and their effective production by plant cell cultures` by Prof. Inoue of Gifu Pharmaceutical University. 27 refs., 13 figs., 1 tab.

Balloon catheter dilatation for mitral stenosis and severe pulmonary hypertension

International Nuclear Information System (INIS)

Wang Manhong

2002-01-01

Objective: To determine the safety and efficacy of percutaneous balloon mitral valvuloplasty (PBMV) for patients with mitral stenosis and severe pulmonary hypertension, and to assess the changes in pulmonary systolic pressure during follow-up. Methods: Forty-two patients with rheumatic mitral stenosis and severe pulmonary hypertension (pulmonary systolic pressure > 75 mmHg) underwent PBMV using standard Inoue technique, and the changes in clinical functional status and echo Doppler pulmonary systolic pressure during follow-up were assessed. Results: PBMV was successful in 39 patients. Immediately after the procedure, mitral valve area increased from (0.83 +- 0.12) cm 2 to (1.75 +- 0.11) cm 2 , pulmonary systolic pressure decreased from (85 +- 7) mmHg to (61 +- 13) mmHg (all P < 0.001). Severe mitral regurgitation occurred in 3 patients, one of whom underwent mitral valve replacement. During follow-up (average 6 months), in 39 patients with successful PBMV, the clinical functional status was improved and pulmonary systolic pressure was further decreased despite unchanged mitral valve area. Conclusions: PBMV was safe and effective for patients with mitral stenosis and severe pulmonary hypertension. Clinical functional status was improved and pulmonary systolic pressure was continuously decreased during the short-term follow-up

First measurement of target and double spin asymmetries for polarized e- polarized p --> e p pi0 in the nucleon resonance region above the Delta(1232)

Energy Technology Data Exchange (ETDEWEB)

Biselli, Angela; Burkert, Volker; Amaryan, Moscov; Amaryan, Moskov; Asryan, Gegham; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Baillie, Nathan; Ball, J.P.; Ball, Jacques; Baltzell, Nathan; Battaglieri, Marco; Bedlinskiy, Ivan; Bellis, Matthew; Benmouna, Nawal; Berman, Barry; Blaszczyk, Lukasz; Bookwalter, Craig; Boyarinov, Sergey; Bosted, Peter; Bradford, Robert; Branford, Derek; Briscoe, William; Brooks, William; Bultmann, S.; Bueltmann, Stephen; Butuceanu, Cornel; Calarco, John; Careccia, Sharon; Carman, Daniel; Casey, Liam; Chen, Shifeng; Cheng, Lu; Cole, Philip; Collins, Patrick; Coltharp, Philip; Crabb, Donald; Crede, Volker; Dale, Daniel; Dashyan, Natalya; De Masi, Rita; De Vita, Raffaella; De Sanctis, Enzo; Degtiarenko, Pavel; Deur, Alexandre; Dhamija, Seema; Dickson, Richard; Djalali, Chaden; Dodge, Gail; Doughty, David; Dugger, Michael; Dzyubak, Oleksandr; Egiyan, Hovanes; Elfassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fedotov, Gleb; Feuerbach, Robert; Fersch, Robert; Forest, Tony; Fradi, Ahmed; Garcon, Michel; Gavalian, Gagik; Gevorgyan, Nerses; Gilfoyle, Gerard; Giovanetti, Kevin; Girod, Francois-Xavier; Goetz, John; Gohn, Wesley; Gothe, Ralf; Graham, Lewis; Griffioen, Keith; Guidal, Michel; Guler, Nevzat; Guo, Lei; Gyurjyan, Vardan; Hafidi, Kawtar; Hakobyan, Hayk; Hanretty, Charles; Hassall, Neil; Hicks, Kenneth; Hleiqawi, Ishaq; Holtrop, Maurik; Hyde, Charles; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Ito, Mark; Jenkins, David; Jo, Hyon-Suk; Johnstone, John; Joo, Kyungseon; Juengst, Henry; Kalantarians, Narbe; Keller, Dustin; Kellie, James; Khandaker, Mahbubul; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Kossov, Mikhail; Krahn, Zebulun; Kubarovsky, Valery; Kuhn, Joachim; Kuhn, Sebastian; Kuleshov, Sergey; Kuznetsov, Viacheslav; Lachniet, Jeff; Laget, Jean; Langheinrich, Jorn; Lawrence, David; Livingston, Kenneth; Lu, Haiyun; MacCormick, Marion; Markov, Nikolai; Mattione, Paul; McKinnon, Bryan; McNabb, John; Mecking, Bernhard; Mestayer, Mac; Meyer, Curtis; Mibe, Tsutomu; Mikhaylov, Konstantin; Mirazita, Marco; Mokeev, Viktor; Moreno, Brahim; Moriya, Kei; Morrow, Steven; Moteabbed, Maryam; Munevar Espitia, Edwin; Mutchler, Gordon; Nadel-Turonski, Pawel; Nasseripour, Rakhsha; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Niczyporuk, Bogdan; Niroula, Megh; Niyazov, Rustam; Nozar, Mina; Osipenko, Mikhail; Ostrovidov, Alexander; Park, Kil; Park, Seungkyung; Pasyuk, Evgueni; Paterson, Craig; Pereira, Sergio; Pierce, Joshua; Pivnyuk, Nikolay; Pogorelko, Oleg; Pozdnyakov, Sergey; Price, John; Prok, Yelena; Protopopescu, Dan; Raue, Brian; Ricco, Giovanni; Ripani, Marco; Ritchie, Barry; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Saini, Mukesh; Salamanca, Julian; Salgado, Carlos; Santoro, Joseph; Sapunenko, Vladimir; Schott, Diane; Schumacher, Reinhard; Serov, Vladimir; Sharabian, Youri; Sharov, Dmitri; Shvedunov, Nikolay; Smith, Elton; Sober, Daniel; Sokhan, Daria; Stavinskiy, Aleksey; Stepanyan, Samuel; Stepanyan, Stepan; Stokes, Burnham; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tedeschi, David; Tkabladze, Avtandil; Tkachenko, Svyatoslav; Todor, Luminita; Ungaro, Maurizio; Vineyard, Michael; Vlassov, Alexander; Watts, Daniel; Weinstein, Lawrence; Weygand, Dennis; Williams, M.; Wolin, Elliott; Wood, Michael; Yegneswaran, Amrit; Yurov, Mikhail; Zana, Lorenzo; Zhang, Jixie; Zhao, Bo; Zhao, Zhiwen

2008-10-01

DOI: http://dx.doi.org/10.1103/PhysRevC.78.045204
The exclusive channel polarized proton(polarized e,e prime p)pi0 was studied in the first and second nucleon resonance regions in the Q2 range from 0.187 to 0.770 GeV2 at Jefferson Lab using the CEBAF Large Acceptance Spectrometer (CLAS). Longitudinal target and beam-target asymmetries were extracted over a large range of center-of-mass angles of the pi0 and compared to the unitary isobar model MAID, the dynamic model by Sato and Lee, and the dynamic model DMT. A strong sensitivity to individual models was observed, in particular for the target asymmetry and in the higher invariant mass region. This data set, once included in the global fits of the above models, is expected to place strong constraints on the electrocoupling amplitudes A_{1/2} and S_{1/2} for the Roper resonance N(1400)P11, and the N(1535)S11 and N(1520)D13 states.

FY 2000 report on the results of the joint research - Field test project on the photovoltaic power generation for public facility use; 2000 nendo kyodokenkyu gyomu seika hokokusho. Kokyo shisetsu you taiyoko hatsuden field test jigyo

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-05-01

The paper arranged the FY 2000 results of the field test on the photovoltaic power generation for public facility use, etc. This report described in detail the results obtained at 237 places including the following: Social Welfare Corp. Seimei-kai, Kobe City (Hyogo Prefecture), Iitaka Town of Iinan County (Mie Prefecture), Kyushu Electric Safety Association, Educational Corp. Kongo Gakuen, Social Welfare Corp. Izumi-kai, Educational Corp. Shiobara Ikuei-kai, Educational Corp. Aiko Gakuen, Social Welfare Corp. Tachibana-kai, Cooperative Association Co-op Kobe, Social Welfare Corp. Hoshizuki-no-sato, Tochigi-Fuji Industrial Co., Hirabayashi Section of Gamo Town of Gamo County (Shiga Prefecture), Yanagawa City (Fukuoka Prefecture), Imadate City of Imadate County (Fukui Prefecture), Osaka Prefecture, Yamanashi Prefecture, Utazu Town of Ayauta County (Kagawa Prefecture), Educational Corp. Fukuyama Gakuen, New Energy Business Cooperative Association, Meitec Corp., Shikoku Medicom Co., Shizen Kobo Co., Educational Corp. Horikoshi Gakuen, Matama Town of Nishi-Kunisaki County (Oita Prefecture), Nio Town of Mitoyo County (Kagawa Prefecture), Educational Corp. Koshien Gakuin, Sansei Giken Co., Mitsui Greenland Co., AWI Mach Co., Nagoya City and Educational Corp. Kibogaoka Gakuen. (NEDO)

Development of reactor design aid tool using virtual reality technology

International Nuclear Information System (INIS)

Mizuguchi, N.; Tamura, Y.; Imagawa, S.; Sagara, A.; Hayashi, T.

2006-01-01

A new type of aid system for fusion reactor design, to which the virtual reality (VR) visualization and sonification techniques are applied, is developed. This system provides us with an intuitive interaction environment in the VR space between the observer and the designed objects constructed by the conventional 3D computer-aided design (CAD) system. We have applied the design aid tool to the heliotron-type fusion reactor design activity FFHR2m [A. Sagara, S. Imagawa, O. Mitarai, T. Dolan, T. Tanaka, Y. Kubota, et al., Improved structure and long -life blanket concepts for heliotron reactors, Nucl. Fusion 45 (2005) 258-263] on the virtual reality system CompleXcope [Y. Tamura, A. Kageyama, T. Sato, S. Fujiwara, H. Nakamura, Virtual reality system to visualize and auralize numerical imulation data, Comp. Phys. Comm. 142 (2001) 227-230] of the National Institute for Fusion Science, Japan, and have evaluated its performance. The tool includes the functions of transfer of the observer, translation and scaling of the objects, recording of the operations and the check of interference

Palonosetron-A Single-Dose Antiemetic Adjunct for Hepatic Artery Radioembolization: A Feasibility Study

International Nuclear Information System (INIS)

Siddiqi, Nasir H.; Khan, Atif J.; Devlin, Phillip M.

2009-01-01

Nausea and vomiting may occur in a significant minority of patients following hepatic artery embolization with yttrium-90 spheres (K. T. Sato et al. Radiology 247:507-515, 2008). This encumbers human and economic resources and undercuts the assertion that it is as a well-tolerated outpatient treatment. A single intravenous dose of palonosetron HCl was administered before hepatic artery embolization with yttrium-90 spheres to ameliorate posttreatment nausea and vomiting, in 23 consecutive patients. The patients were discharged the day of procedure on oral antiemetics, steroids, and blockers of gastric acid release. All patients had clinical and laboratory evaluation at 2 weeks after the procedure. The data were gathered and reviewed retrospectively. At 2-week follow-up, none reported significant nausea, vomiting, additional antiemetic use, need for parenteral therapy, hospital readmission, or palonosetron-related side effects. All patients recovered from postembolization symptoms within a week after treatment. In conclusion, this retrospective study suggests that single-dose palonosetron is feasible, safe, and effective for acute and delayed nausea and vomiting in this group of patients. The added cost may be offset by benefits.

PRECURSORY SLOPE DEFORMATION AROUND LANDSLIDE AREA DETECTED BY INSAR THROUGHOUT JAPAN

Directory of Open Access Journals (Sweden)

T. Nakano

2016-06-01

Full Text Available Interferometric Synthetic Aperture Radar (InSAR technique is able to detect a slope deformation around landslide (e.g., Singhroy et al., 2004; Une et al., 2008; Riedel and Walther, 2008; Sato et al., 2014. Geospatial Information Authority (GSI of Japan has been performing the InSAR analysis regularly by using ALOS/PALSAR data and ALOS-2/PALSAR-2 data throughout Japan. There are a lot of small phase change sites except for crustal deformation with earthquake or volcano activity in the InSAR imagery. Most of the phase change sites are located in landslide area. We conducted field survey at the 10 sites of those phase change sites. As a result, we identified deformation of artificial structures or linear depressions caused by mass movement at the 9 sites. This result indicates that InSAR technique can detect on the continual deformation of landslide block for several years. GSI of Japan will continue to perform the InSAR analysis throughout Japan. Therefore, we will be able to observe and monitor precursory slope deformation around landslide areas throughout Japan.

In-situ straining and time-resolved electron tomography data acquisition in a transmission electron microscope.

Science.gov (United States)

Hata, S; Miyazaki, S; Gondo, T; Kawamoto, K; Horii, N; Sato, K; Furukawa, H; Kudo, H; Miyazaki, H; Murayama, M

2017-04-01

This paper reports the preliminary results of a new in-situ three-dimensional (3D) imaging system for observing plastic deformation behavior in a transmission electron microscope (TEM) as a directly relevant development of the recently reported straining-and-tomography holder [Sato K et al. (2015) Development of a novel straining holder for transmission electron microscopy compatible with single tilt-axis electron tomography. Microsc. 64: 369-375]. We designed an integrated system using the holder and newly developed straining and image-acquisition software and then developed an experimental procedure for in-situ straining and time-resolved electron tomography (ET) data acquisition. The software for image acquisition and 3D visualization was developed based on the commercially available ET software TEMographyTM. We achieved time-resolved 3D visualization of nanometer-scale plastic deformation behavior in a Pb-Sn alloy sample, thus demonstrating the capability of this system for potential applications in materials science. © The Author 2016. Published by Oxford University Press on behalf of The Japanese Society of Microscopy. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

A ductile fracture criterion with Zener-Hollomon parameter of pure molybdenum sheet in thermal forming

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Wang Chu

2015-01-01

Full Text Available Formability of pure molybdenum in thermal forming process has been greatly improved, but it is still hard to avoid the generation of rupture and other quality defects. In this paper, a ductile fracture criterion of pure molybdenum sheet in thermal forming was established by considering the plastic deformation capacity of material and stress states, which can be used to describe fracture behaviour and critical rupture prediction of pure molybdenum sheet during hot forming process. Based on the isothermal uniaxial tensile tests which performed at 993 to 1143 K with strain rate range from 0.0005 to 0.2 s−1, the material parameters are calculated by the combination method of experiment with FEsimulation. Based on the observation, new fracture criteria can be expressed as a function of Zener-Hollomon parameter. The critical fracture value that calculated by Oyane-Sato criterion increases with increasing temperature and decreasing strain rate. The ductile fracture criterion with Zener-Hollomon parameter of pure molybdenum in thermal forming is proposed.

Industrial excellence is rewarded by CMS

CERN Multimedia

2005-01-01

As part of the sixth annual ceremony to honour its top suppliers, the CMS collaboration presented awards to nine firms. The representatives of the firms that received the CMS best supplier awards displaying their awards on 5 April. From left to right: C. Fulvia (Plyform), K. Sato and K. Yamamura (Hamamatsu Photonics), G. Roveta (Criotec Impianti), M. Fornari (Telema), H. P. Reinhardt (Reinhardt Microtech), M. Sonninen (Planar Systems), E.  Dyakov (Lutch), M. Mottier (NGK Instulators) and J. Vital (Chipidea Microelectronics). With progress being made on the construction of the CMS experiment, attention was turned towards other parts of the detector during the collaboration's sixth annual ceremony to honour its top suppliers. After the magnet which took centre stage at previous ceremonies, on Tuesday 5 April, it was the turn of the tracker to step into the limelight. Of the nine firms to receive awards this year, five are involved in the construction of the tracker, two of which received the highes...

Potential energy surfaces for electron dynamics modeled by floating and breathing Gaussian wave packets with valence-bond spin-coupling: An analysis of high-harmonic generation spectrum

Science.gov (United States)

Ando, Koji

2018-03-01

A model of localized electron wave packets (EWPs), floating and breathing Gaussians with non-orthogonal valence-bond spin-coupling, is applied to compute the high-harmonic generation (HHG) spectrum from a LiH molecule induced by an intense laser pulse. The characteristic features of the spectrum, a plateau up to 50 harmonic-order and a cutoff, agreed well with those from the previous time-dependent complete active-space self-consistent-field calculation [T. Sato and K. L. Ishikawa, Phys. Rev. A 91, 023417 (2015)]. In contrast to the conventional molecular orbital picture in which the Li 2s and H 1s atomic orbitals are strongly mixed, the present calculation indicates that an incoherent sum of responses of single electrons reproduces the HHG spectrum, in which the contribution from the H 1s electron dominates the plateau and cutoff, whereas the Li 2s electron contributes to the lower frequency response. The results are comprehensive in terms of the shapes of single-electron potential energy curves constructed from the localized EWP model.

On the building of Momoyama hydraulic power station on Kiso river. Kisogawa Momoyama suiryoku hatsudensho no kenchiku ni tsuite

Energy Technology Data Exchange (ETDEWEB)

Kotera, T [Nagoya University, Nagoya (Japan). Faculty of Engineering

1991-09-30

This paper investigates Momoyama hydraulic power station built on the middle reaches of the Kiso River in Uematsu-cho, Kiso-gun, Nagano Prefecture in Japan, in 1923 by relating to the feature of the building of the hydraulic power station and the architect, Shiro Sato. The hydraulic power station originally was a functional and industrial building which puts a priority on the efficiency of business economy, at the same time it was often required to present a beautiful appearance. The building of Momoyama hydraulic power station was founded on the crane girder structure covered with reinforced concrete(RC) walls. A Hat roof of RC slab was applied to the roof of the building. It was generally designed in Neo-Gothic style. More specifically, however, the wall surface was designed in church style and the upper part was like a castle in the middle ages. Therefore the total design was eclectic. The outer surfaces of the building were remained to be bare concrete as cast. Such a multiple building symbolizes the situation of Japanes architecture in the 1920s. 4 figs.

Help-seeking behavior among Japanese school students who self-harm: results from a self-report survey of 18,104 adolescents

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Furukawa TA

2012-11-01

Full Text Available Norio Watanabe,1,* Atsushi Nishida,2,* Shinji Shimodera,3 Ken Inoue,4 Norihito Oshima,5 Tsukasa Sasaki,6 Shimpei Inoue,3 Tatsuo Akechi,1 Toshi A Furukawa,7 Yuji Okazaki81Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, 2Department of Schizophrenia Research, Tokyo Institute of Psychiatry, Tokyo, 3Department of Neuropsychiatry, Kochi Medical School, Kochi, 4Department Public Health, Fujita Health University School of Medicine, Aichi, 5Office for Mental Health Support, Division for Counseling and Support, University of Tokyo, Tokyo, 6Health Service Center, University of Tokyo, Tokyo, 7Department of Cognitive-Behavioral Medicine, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, 8Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan *These authors contributed equally to this workBackground: The aim of this study was to determine the prevalence of and factors associated with poor help-seeking among adolescents who self-harm and to explore the resources used for help.Methods: A cross-sectional survey using an anonymous questionnaire was conducted in 47 junior and 30 senior high schools in Japan. Adolescent self-harm was defined as an adolescent who had harmed himself or herself in the previous year, as in previous studies reported in Western countries. Poor help-seeking was defined as not consulting anyone despite reporting current psychological or somatic complaints. Information about sociodemographic and psychological factors possibly associated with help-seeking, such as suicidal thoughts, depression, anxiety, and psychotic-like experiences, was also collected. Regression analyses were performed to examine associated factors.Results: A total of 18,104 students (8620 aged 12–15 years, 9484 aged 15–18 years, accounting for 93% of all students in the relevant student classes, participated in the study. Two hundred and

Conservação de goiabas tratadas com emulsões de cera de carnaúba Postharvest conservation of guavas through carnauba wax emulsion applications

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Angelo Pedro Jacomino

2003-12-01

Full Text Available A goiaba é um fruto muito perecível. Assim, objetivou-se avaliar os efeitos de ceras à base de carnaúba na conservação pós-colheita de goiabas Pedro Sato sob condição ambiente. Utilizaram-se cinco ceras comerciais: Citrosol AK (18%, Citrosol M (10%, Fruit wax (18 a 21%, Meghwax ECF-100 (30% e Cleantex wax (18,5 a 20,5%, as quais foram aplicadas manualmente, na proporção de 0,15 a 0,20mL por fruta. Frutas sem aplicação de cera foram utilizadas como controle. O delineamento experimental foi inteiramente casualizado com 6 tratamentos, 4 repetições e 5 frutas por parcela. As goiabas foram caracterizadas imediatamente após a colheita e avaliadas aos 2, 4 e 6 dias após a aplicação dos tratamentos. As ceras exerceram pouca influência nos teores de sólidos solúveis totais, acidez total titulável e ácido ascórbico, porém, foram eficientes em retardar o amadurecimento, reduzir a perda de massa e a incidência de podridões. A cera Meghwax ECF-100 apresenta potencial para utilização em goiabas, porém há necessidade de ser avaliada em maior diluição, para evitar alterações indesejáveis.Guavas are very perishable fruits. Therefore, the objective of the present work was to evaluate the effects of several carnauba based waxes in the postharvest life of Pedro Sato guavas under room conditions. Five commercial waxes were used: Citrosol AK (18%, Citrosol M (10%, Fruit wax (18 a 21%, Meghwax ECF-100 (30% e Cleantex wax (18,5 a 20,5%. The waxes were applied manualy in the rate of 0.15 to 0.20mL of wax per fruit. Control fruits were not treated. The experiment was conducted in a completely randomized design with 6 treatments, 4 replicates per treatment and 5 fruits as experimental unit. Guavas were evaluated at harvest and at every 2 days until the 6th day after treatments. Waxing had little effect on total soluble solids, total titratable acidity and ascorbic acid contents. However, the waxes were efficient in delaying ripening

Extração de pectina de goiaba desidratada Extraction of pectin from dehydrated guava

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Cláudia Leite Munhoz

2010-03-01

Full Text Available Goiabas (Psidium guajava L. cultivar Pedro Sato foram utilizadas para extração de pectina. Os frutos separados polpa e polpa com casca foram secos em estufa com circulação de ar. Amostras secas foram caracterizadas física e quimicamente. O planejamento composto central rotacional com quatro pontos axiais e três repetições no ponto central foi utilizado para determinar o rendimento de extração de pectina das farinhas de polpa e de polpa com casca de goiaba. A extração foi realizada em 4 g de farinha para 200 mL de solução de ácido cítrico em diferentes concentrações e em diferentes tempos de extração, a temperatura de 97 ºC. As pectinas obtidas nas melhores condições de extração foram caracterizadas. A extração de pectina com ácido cítrico e precipitação alcoólica forneceu rendimentos acima de 11% para a farinha de polpa e de polpa com casca de goiaba. As melhores condições de extração foram: concentração de ácido cítrico de 5 g.100 g-1 e tempo de extração de 60 minutos. As pectinas obtidas apresentaram-se de baixa esterificação e com teor de ácido galacturônico próximo ao padrão comercial (65%.Pedro Sato cultivar guavas (Psidium guajava L. were used for extraction of pectin. The fruits were divided into pulp and pulp with peel, and dried in a stove with air circulation. Dry samples were characterized physically and chemically. The planning consisted of central axial rotation with four points, and three replicates in the central point were used to determine the extraction yield of pectin flour from the guava pulp and pulp with peel. The extraction was performed in 4 g of flour to 200 mL of solution of citric acid at different concentrations and at different times of extraction, at a temperature of 97 ºC. The pectins obtained in optimum conditions for extraction were characterized. The extraction of pectin with citric acid and alcohol precipitation provided yield above 11% for the guava flour, with

An update on purple urine bag syndrome

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Hadano Y

2012-08-01

Full Text Available Yoshiro Hadano,1 Taro Shimizu,2 Shimon Takada,3 Toshiya Inoue,4 Sumire Sorano51Department of General Internal Medicine and Infectious Diseases, Rakuwakai Otowa Hospital, Yamashina-ku, Kyoto, Japan; 2Rollins School of Public Health, Emory University, Atlanta, GA, USA; 3Department of General Internal Medicine, Osaka City General Hospital, Miyakojima-ku, Osaka, Japan; 4Department of Emergency Medicine, Urasoe General Hospital, Urasoe-city, Okinawa, Japan; 5Kobe University School of Medicine, Kusunokicho, Chuoku, Kobe, JapanAbstract: Purple urine bag syndrome is characterized by the urinary drainage bag turning purple in patients on prolonged urinary catheterization, especially those in the bedridden state. It is associated with bacterial urinary tract infections caused by indigo-producing and indirubin-producing bacteria, usually affects women, and is associated with alkaline urine, constipation, and a high bacterial load in the urine. Almost all patients with purple urine bag syndrome are catheterized due to significant disability, and the urinary pH is 7.0 or more. In general, intensive treatment with antibiotics is not recommended. Purple urine bag syndrome per se almost always appears to be asymptomatic and harmless. However, caution is needed, because some cases have been reported to show progression to severe disease states, so further research into the morbidity and mortality of this infection is warranted.Keywords: purple urine, urinary catheterization, geriatrics, urinary tract infection

Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension

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Inoue K

2012-01-01

Full Text Available Kenji Inoue1, Minako Shiokawa1, Michitaka Sugahara1, Risako Higa1, Masato Wakakura1, Goji Tomita21Inouye Eye Hospital, Tokyo, Japan; 2Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To prospectively investigate adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension. We also examined patient attitudes to adverse reactions via a questionnaire.Methods: Fifty-two Japanese patients with glaucoma or ocular hypertension were enrolled. Iridial, eyelid, and eyelash photographs were taken before and at 6 months after bimatoprost treatment. Increase in eyelid pigmentation, iridial pigmentation, eyelash growth and bristle, and vellus hair of the lid was assessed from the photographs. Questionnaires completed by patients provided insight into their subjective judgment of adverse reactions.Results: Increase in eyelash bristle (53.8%, iris pigmentation (50.0%, eyelash growth (46.2%, vellus hair of the lid (40.4%, and eyelid pigmentation (7.7% was evident after bimatoprost treatment. The objective and subjective assessments were in agreement in terms of increase in eyelash bristle, eyelash growth, and increase in vellus hair of the lid.Conclusion: Most patients were conscious of these adverse reactions. Before administering bimatoprost, sufficient explanation of potential adverse reactions should be provided; after initiating treatment, careful observation is required.Keywords: bimatoprost, adverse reaction, eyelid pigmentation, changes in eyelashes, iris pigmentation 

PREFACE: ELC International Meeting on Inference, Computation, and Spin Glasses (ICSG2013)

Science.gov (United States)

Kabashima, Yoshiyuki; Hukushima, Koji; Inoue, Jun-ichi; Tanaka, Toshiyuki; Watanabe, Osamu

2013-12-01

The close relationship between probability-based inference and statistical mechanics of disordered systems has been noted for some time. This relationship has provided researchers with a theoretical foundation in various fields of information processing for analytical performance evaluation and construction of efficient algorithms based on message-passing or Monte Carlo sampling schemes. The ELC International Meeting on 'Inference, Computation, and Spin Glasses (ICSG2013)', was held in Sapporo 28-30 July 2013. The meeting was organized as a satellite meeting of STATPHYS25 in order to offer a forum where concerned researchers can assemble and exchange information on the latest results and newly established methodologies, and discuss future directions of the interdisciplinary studies between statistical mechanics and information sciences. Financial support from Grant-in-Aid for Scientific Research on Innovative Areas, MEXT, Japan 'Exploring the Limits of Computation (ELC)' is gratefully acknowledged. We are pleased to publish 23 papers contributed by invited speakers of ICSG2013 in this volume of Journal of Physics: Conference Series. We hope that this volume will promote further development of this highly vigorous interdisciplinary field between statistical mechanics and information/computer science. Editors and ICSG2013 Organizing Committee: Koji Hukushima Jun-ichi Inoue (Local Chair of ICSG2013) Yoshiyuki Kabashima (Editor-in-Chief) Toshiyuki Tanaka Osamu Watanabe (General Chair of ICSG2013)

Sm-Nd, Rb-Sr and K-Ar age constraints of the El Molle and Barroso plutons, western Sierra de San Luis, Argentina

International Nuclear Information System (INIS)

Sato, A.M.; Gonzalez, P.D; Petronilho, L.A; Llambias, E.J.; Varela, R; Basei, M.A.S

2001-01-01

Within the Early Paleozoic Famatinian orogeny of Southern Sierras Pampeanas (Sierra de San Luis and Sierra de Cordoba), the post-orogenic granitoids are characterized by circular intrusions. The published Rb-Sr and K-Ar ages from plutons in the Sierra de San Luis range between 408 and 320 Ma (see synthesis in Llambias et al., 1998). The El Molle and Barroso plutons (Sims et al., 1997; Gonzalez and Sato, 2000) are the two main exposures of a post-orogenic intrusive complex located in the western area of the Sierra de San Luis basement. They also exhibit an overall circular map view of almost 8 km in diameter, and are emplaced in a metamorphic complex developed through pre-Famatinian (Proterozoic? to Early Paleozoic) to Famatinian (Early Paleozoic) orogenies (Gonzalez and Llambias, 1998; von Gosen and Prozzi, 1998). We are carrying out isotopic datings of the El Molle and Barroso plutons in order to contribute to the understanding of the magmatic and metamorphic evolution of the final stages of the Famatinian orogenic cycle in the Sierra de San Luis. The first results of the Sm-Nd, Rb-Sr and K-Ar dates are here presented (au)

Emergency and disaster preparedness for chronically ill patients: a review of recommendations

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Tomio J

2014-12-01

Full Text Available Jun Tomio,1 Hajime Sato2 1Department of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 2Department of Health Policy and Technology Assessment, National Institute of Public Health, Wako, Japan Abstract: Recent disasters, especially those in developed countries, have highlighted the importance of disaster preparedness measures for chronic diseases. A number of surviving patients experienced the exacerbation of a chronic illness, such as hypertension, diabetes, cancer, and chronic respiratory diseases, due to disaster-related stress, interruption of care, or both; for some patients, these exacerbations resulted in death. Here, we review reports from recent disasters in developed countries and summarize the recommendations for disaster preparedness of chronically ill patients. A considerable number of recommendations based on the lessons learned from recent disasters have been developed, and they provide practical and essential steps to prevent treatment interruption during and after a disaster. To improve preparedness efforts, we suggest that health care providers should be aware of the following three suggestions: 1 recommendations should be evidence-based; 2 recommendations should contain consistent messages; and 3 recommendations should be feasible. Keywords: disaster, chronic illness, preparedness

The KP Hierarchy and Aspects of the Painlevé Property

Science.gov (United States)

Strampp, W.; Langer, C.

1990-12-01

We are concerned with the conjecture that the Painlevé property is a necessary condition for the integrability of nonlinear equations. Following a suggestion by lietratures (1) D. V. Chudnovsky, G. V. Chudnovsky and M. Tabor, Phys. Lett. 97A (1983), 268, and 2) A. K. Pogrebkov, Inverse Problems 5 (1989), L7), our investigations will be based on the Lax-pair which we use in Sato's sense (3) E. Date, M. Jimbo, M. Kashiwara and T. Miwa in Nonlinear Integrable Systems-Classical and Quantum Theory, ed. M. Jimbo and T. Miwa (World Scientific, Singapore, 1983), p. 39, 4) M. Jimbo and T. Miwa, Publ. RIMS, Kyoto Univ. 19 (1983), 943, 5) Y. Ohta, J. Satsuma, D. Takahashi and T. Tokihiro, Prog. Theor. Phys. Suppl. No. 94 (1988), 210). Leading orders, branch points and resonances are described for the Zakharov-Shabat equations of the KP-hierarchy. The symbolic manipulation system REDUCE, in particular its factorization algorithm for polynomials, is employed for finding the resonances. It is shown that the Painlevé structures of various nonlinear equations, which have been discussed a lot in the literature, follow from our results.

Isolation and characterization of major histocompatibility complex class IIB genes from the nurse shark.

Science.gov (United States)

Bartl, S; Weissman, I L

1994-01-04

The major histocompatibility complex (MHC) contains a set of linked genes which encode cell surface proteins involved in the binding of small peptide antigens for their subsequent recognition by T lymphocytes. MHC proteins share structural features and the presence and location of polymorphic residues which play a role in the binding of antigens. In order to compare the structure of these molecules and gain insights into their evolution, we have isolated two MHC class IIB genes from the nurse shark, Ginglymostoma cirratum. Two clones, most probably alleles, encode proteins which differ by 13 amino acids located in the putative antigen-binding cleft. The protein structure and the location of polymorphic residues are similar to their mammalian counterparts. Although these genes appear to encode a typical MHC protein, no T-cell-mediated responses have been demonstrated in cartilaginous fish. The nurse shark represents the most phylogenetically primitive organism in which both class IIA [Kasahara, M., Vazquez, M., Sato, K., McKinney, E.C. & Flajnik, M.F. (1992) Proc. Natl. Acad. Sci USA 89, 6688-6692] and class IIB genes, presumably encoding the alpha/beta heterodimer, have been isolated.

Nuclear magnetic resonance: A new tool for the validation of multiphase multidimensional CFD codes

International Nuclear Information System (INIS)

Lemonnier, H.

2010-01-01

Turbulent transport models and data in bubbly flows are briefly reviewed since they play an important role in the modeling of boiling flows in forced convection. Shortcomings of earlier measurements of the eddy diffusivity by NMR (Lemonnier and Leblond, 2007b) are analyzed and a new procedure is presented which is now consistent with the procedure of Gatenby and Gore (1994) developed for single-phase turbulent flow characterization. The newly estimated eddy diffusivity agrees now with that previously obtained by Serizawa et al. (1975b) with a thermal method and that of the model of Sato and Sadatomi (1981). This procedure also provides the liquid velocity fluctuation RMS and the Lagrangian correlation time of velocity fluctuations. In addition, the same NMR technique provides also the area-averaged liquid velocity and void fraction. Bubbly flow data up to transition to slug flow are provided which also agree with existing drift-flux models (Ishii and Hibiki, 2006). It is finally discussed how the NMR method can be extended to local measurements and may provide a fully non-intrusive diagnostic in two-phase flows and which is not limited to bubbly flow.

Nuclear magnetic resonance: A new tool for the validation of multiphase multidimensional CFD codes

Energy Technology Data Exchange (ETDEWEB)

Lemonnier, H., E-mail: herve.lemonnier@cea.f [DTN/SE2T, CEA/Grenoble, 38054 Grenoble Cedex 9 (France)

2010-09-15

Turbulent transport models and data in bubbly flows are briefly reviewed since they play an important role in the modeling of boiling flows in forced convection. Shortcomings of earlier measurements of the eddy diffusivity by NMR (Lemonnier and Leblond, 2007b) are analyzed and a new procedure is presented which is now consistent with the procedure of Gatenby and Gore (1994) developed for single-phase turbulent flow characterization. The newly estimated eddy diffusivity agrees now with that previously obtained by Serizawa et al. (1975b) with a thermal method and that of the model of Sato and Sadatomi (1981). This procedure also provides the liquid velocity fluctuation RMS and the Lagrangian correlation time of velocity fluctuations. In addition, the same NMR technique provides also the area-averaged liquid velocity and void fraction. Bubbly flow data up to transition to slug flow are provided which also agree with existing drift-flux models (Ishii and Hibiki, 2006). It is finally discussed how the NMR method can be extended to local measurements and may provide a fully non-intrusive diagnostic in two-phase flows and which is not limited to bubbly flow.

China's energy consumption: A perspective from Divisia aggregation approach

International Nuclear Information System (INIS)

Liao, Hua; Wei, Yi-Ming

2010-01-01

China's total energy consumption, according to the official data, decreased impressively during 1997-1998 and increased sharply during 2003-2007, which in turn resulted in energy intensity fluctuation. Many literatures explained this ''unusual phenomenon'' from the perspectives of technical change, economic structure shifting and statistical data quality. They measured aggregate energy in thermal units by using linear summation approaches. In this paper, from the perspectives of heterogeneity and imperfect substitutability among diverse energy types, we further examine China's aggregate energy consumption by using Divisia (Sato-Vartia) approach. The results show that China's aggregate energy consumption and intensity fluctuated slightly less than values calculated by using conventional linear approaches, and the ''unusual phenomenon'' is partly explained. It also implies that China's energy intensity changes in 2006-2007 are slightly more optimistic than those officially reported, and the official communique of provincial energy intensity reduction achievements are partly bias. Some provincial achievement are underestimated or overestimated on some provinces. Our empirical results are also helpful to further research, such as energy-economic modeling, energy price elasticity, and elasticity of substitution among capital-labor-energy-material (KLEM). The difficulties or defects when using Divisia approach are also discussed in this paper. (author)

Vitamin D deficiency and stroke

Directory of Open Access Journals (Sweden)

2012-12-01

Full Text Available Vitamin D comprises a group of fat-soluble pro-hormones, obtained from sun exposure, food, and supplements, and it must undergo two hydroxylation reactions to be activated in the body. Several studies have shown the role of vitamin D in mineral metabolism regulation, especially calcium, phosphorus, and bone metabolism. Some factors such as inadequate vitamin intake and liver or kidney disorders can lead to vitamin D deficiency. Furthermore, vitamin D malnutrition may also be linked to susceptibility to chronic diseases such as heart failure, peripheral artery disease, high blood pressure, cognitive impairment including foggy brain and memory loss, and autoimmune diseases including diabetes type I. Recent research has revealed that low levels of vitamin D increase the risk of cardiovascular-related morbidity (Sato et al., 2004 and mortality (Pilz et al., 2008. Also, hypertension contributes to a reduction in bone mineral density and increase in the incidence of stroke and death. This article reviews the function and physiology of vitamin D and examines the effects of vitamin D deficiency on susceptibility to stroke, as a cardiovascular event, and its morbidity and subsequent mortality.

What induced China's energy intensity to fluctuate: 1997-2006?

International Nuclear Information System (INIS)

Liao, Hua; Fan, Ying; Wei, Yi-Ming

2007-01-01

China is the second largest energy consumer in the world. During 1997-2002, China's energy intensity declined by 33%. However, it rose by 10.7% over 2003-2005, and declined by 1.2% in 2006. What induced China's energy intensity to fluctuate so drastically? Industry accounts for approximately 70% of the total energy consumption in China. In this paper, we decompose China's industrial energy intensity changes between 1997 and 2002 into sectoral structural effects and efficiency effects (measured by sectoral energy intensities at two-digit level and including the shifts of product mix in the sub-sector or firm level), using Toernqvist and Sato-Vartia Index methods. The results show that in this period, efficiency effects possibly contributed to a majority of the decline, while the contribution from structural effects was less. During 2003-2005, the excessive expansion of high-energy consuming sub-sectors and the high investment ratio were foremost sources of the increasing energy intensity. Attributed to the government efforts, the energy intensity has started to decline slightly since July 2006. In future, to save more energy, in addition to technical progress, China should attach more importance to optimizing its sectoral structure, and lowering its investment ratio

PET diagnosis. The decisive factor for early detection of the cancer

International Nuclear Information System (INIS)

Yonekura, Yoshiharu; Kusakabe, Kiyoko; Fukuda, Hiroshi; Inoue, Kentaro; Tanaka, Koichi; Murayama, Hideo; Amano, Masaharu; Oikawa, Koichi; Yamashita, Takashi

2007-01-01

The feature contains 8 articles concerned with the subject matter in the title. The first is a document of the interview with Dr. Yoshiharu Yonekura, the National Institute of Radiological Sciences (NIRS) President, by the editor in chief of the journal, entitled ''Twenty to Thirty years are Necessary for Development of Basic Technology''- discussed are progress of molecular imaging, present and future of positron emission tomography (PET) diagnosis. Lasting are the articles of: ''Recommendation for PET diagnosis'' by K. Kusakabe, Tokyo Women's Medical Univ.- the role of PET diagnosis in a mass examination; ''The present state and future development of PET diagnosis of cancer'' by H. Fukuda and K. Inoue, Tohoku Univ. Hospital- labeled compounds and others; ''Promotion of popularization of the diagnosis as a part of CSR (corporate social responsibility) in the local medicare- A participation of the Hospital of Chugoku Electric Power Co., Ltd. in the project'' by K. Tanaka; ''Trend of development of next generation PET equipment'' by H. Murayama, NIRS- equipments like PET/CT or PET/MRI, and with high system sensitivity (detector- and photo-elements, DOI detection, high performance circuit, etc.); ''Achievement and developing trend of the equipments in the manufacturer- Shimadzu Corp.'' by M. Amano- PET/CT; ''(the same title)- Sumitomo Heavy Industries, Ltd.'' by K. Oikawa- cyclotron and therapeutic heavy ion beam generator; and ''Research and development in Hamamatsu Photonics K.K.'' by T. Yamashita- high throughput PET and animal PET. (R.T.)

A single daily dose enhances the adherence to immunosuppressive treatment in kidney transplant recipients: a cross-sectional study.

Science.gov (United States)

Obi, Yoshitsugu; Ichimaru, Naotsugu; Kato, Taigo; Kaimori, Jun-Ya; Okumi, Masayoshi; Yazawa, Koji; Rakugi, Hiromi; Nonomura, Norio; Isaka, Yoshitaka; Takahara, Shiro

2013-04-01

Nonadherence to treatment regimens for immunosuppressive agents is one of the major risk factors for allograft failure in kidney transplant recipients. The aim of this study was to estimate the relative effect of daily dosing on treatment adherence, not to identify how patients are non-adherent, in long-term kidney transplant recipients. In January 2009, a cross-sectional, anonymous, and voluntary questionnaire survey was given to kidney transplant recipients who regularly visited Inoue Hospital. A self-reporting questionnaire underestimates nonadherence, but we reasoned that the effect of the dosing regimen should be estimated with relative accuracy by using the generalized ordered logit/partial proportional hazard odds model given that the distribution patterns in the degree of nonadherence have been shown to be similar with other measures. Of 336 eligible patients, 312 (92.9 %) participated in this study. Two hundred seventy-four patients (87.8 %) were more than 3 years post-transplant. Univariate analysis revealed that a single daily dose was significantly associated with better adherence. After controlling for age, sex, time since transplantation, and the number of prescribed drugs, the effect of a single daily dose still remained significant [odds ratio, 0.40 (95 % confidence interval, 0.19-0.81); p = 0.011]. Several sensitivity analyses yielded similar results. To our knowledge, this is the first report that, in long-term kidney transplant recipients, a single daily regimen-one of few modifiable factors-might improve treatment adherence and allograft survival.

A case of anterior ischemic optic neuropathy associated with uveitis

Directory of Open Access Journals (Sweden)

Sugahara M

2013-05-01

Full Text Available Michitaka Sugahara, Takayuki Fujimoto, Kyoko Shidara, Kenji Inoue, Masato Wakakura Inouye Eye Hospital, Tokyo, Japan Introduction: Here, we describe a patient who presented with anterior ischemic optic neuropathy (AION and subsequently developed uveitis. Case: A 69-year-old man was referred to our hospital and initially presented with best-corrected visual acuities (BCVA of 20/40 (right eye and 20/1000 (left eye and relative afferent pupillary defect. Slit-lamp examination revealed no signs of ocular inflammation in either eye. Fundus examination revealed left-eye swelling and a pale superior optic disc, and Goldmann perimetry revealed left-eye inferior hemianopia. The patient was diagnosed with nonarteritic AION in the left eye. One week later, the patient returned to the hospital because of vision loss. The BCVA of the left eye was so poor that the patient could only count fingers. Slit-lamp examination revealed 1+ cells in the anterior chamber and the anterior vitreous in both eyes. Funduscopic examination revealed vasculitis and exudates in both eyes. The patient was diagnosed with bilateral panuveitis, and treatment with topical betamethasone was started. No other physical findings resulting from other autoimmune or infectious diseases were found. No additional treatments were administered, and optic disc edema in the left eye improved, and the retinal exudates disappeared in 3 months. The patient's BCVA improved after cataract surgery was performed. Conclusion: Panuveitis most likely manifests after the development of AION. Keywords: anterior ischemic optic neuropathy, uveitis

Temporal Change in Coda Wave Attenuation Observed at Colima Volcano

Science.gov (United States)

DOMINGUEZ, T.; FLORES, F.; REYES, G.

2001-12-01

The last eruptive processes of Colima volcano (November 1998- January 1999) was characterized by the occurrence of several seismic swarms. During the year previous to the eruption, the seismic activity developed in such a form that we could identified several stages in the evolution of the activity. By measuring the amplitude decay of coda waves we estimated coda attenuation Qc in the frequency range 2-10 Hz. We used Sato's (1977) single scattering model for coda windows of 10 to 15 seconds beginning at twice the S-wave travel time. We found a change in Q0 of approximately a 20-30% lower toward the end of the period. We also found that Qc was frequency dependent within this range. This dependence was progressively lower until the last month of activity just before the eruption. Studies of the same type that have been carried out in other volcanoes (Fehler, et al., 1998, Londoño, 1996) showed changes in the attenuation of the seismic waves related to volcanic eruptions. Changes of coda Q can be attributed to the change of density of the open microcracks in the rocks because of the pressure generated by the pushing of magma toward the surface which is also responsible for the inflation of the volcanic edifice.

Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes

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ANDERSON A. SIMÃO

Full Text Available ABSTRACT Leaves of Psidium guajava L. (guava have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI on α-amylase, α-glycosidase, lipase, and trypsin enzymes, in the presence or not of simulated gastric fluid and to determine the content of phenolic compounds by high performance liquid chromatography. All cultivars presented the same composition in phenolic compounds, but in different proportions. The compounds identified are gallic acid, epigallocatechin gallate, syringic acid, o-coumaric acid, resveratrol, quercetin, and catechin (which was the major compound in all the cultivars evaluated. In the absence of simulated gastric fluid, it was observed different inhibitions exercised by the leaves aqueous extracts from three cultivars of P. guajava on each enzyme. In presence of simulated gastric fluid, all cultivars showed increase in the inhibition of lipase and α-glycosidase, and decrease in inhibition of α-amylase and trypsin enzymes. These results indicate that P. guajava leaves aqueous extracts from all cultivars evaluated possess potential of use as an adjuvant in the treatment of obesity and other dyslipidemias.

Aqueous extract of Psidium guajava leaves: phenolic compounds and inhibitory potential on digestive enzymes.

Science.gov (United States)

Simão, Anderson A; Marques, Tamara R; Marcussi, Silvana; Corrêa, Angelita D

2017-01-01

Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment of various diseases. Thus, the objective of this study was to evaluate the inhibitory potential of leaves aqueous extract from three cultivars of P. guajava (Pedro Sato, Paluma and Século XXI) on α-amylase, α-glycosidase, lipase, and trypsin enzymes, in the presence or not of simulated gastric fluid and to determine the content of phenolic compounds by high performance liquid chromatography. All cultivars presented the same composition in phenolic compounds, but in different proportions. The compounds identified are gallic acid, epigallocatechin gallate, syringic acid, o-coumaric acid, resveratrol, quercetin, and catechin (which was the major compound in all the cultivars evaluated). In the absence of simulated gastric fluid, it was observed different inhibitions exercised by the leaves aqueous extracts from three cultivars of P. guajava on each enzyme. In presence of simulated gastric fluid, all cultivars showed increase in the inhibition of lipase and α-glycosidase, and decrease in inhibition of α-amylase and trypsin enzymes. These results indicate that P. guajava leaves aqueous extracts from all cultivars evaluated possess potential of use as an adjuvant in the treatment of obesity and other dyslipidemias.

Einstein model for elementary particles

International Nuclear Information System (INIS)

Sharma, N.K.

1975-01-01

A group theoretical model unifying a space-time group (E) and an internal symmetry group (I) for strongly interacting particles is worked out. The space-time group is the one that pertains to the group of motions of static Einstein cosmological model implying the symmetry of the group E = O 4 logical operation of multiplication R. With the use of Gueret and Vigier prescription, the left coset R logical operation of multiplication O 4 is identified with the internal symmetry group I = U 1 β logical operation of multiplication (SU(2) logical operation of multiplication SU(2)) contains SU(4). The complete dynamical group (D) is then found to be D = E logical operation of multiplication I = (O logical operation of multiplication R) logical operation of multiplication U 1 β logical operation of multiplication (SU(2) logical operation of multiplication SU(2) contains SO(4,2). Physically useful representations of the space-time group (E) are worked out by solving the eigenvalue problem of Laplace-Beltmi operator. The internal quantum numbers are prescribed in accordance with the SU(2) logical operation of multiplication SU(2) model of Nakamura and Sato. A general mass formula is derived and its use for known baryons and mesons is discussed. (author)

Seven years’ experience with etidronate in a woman with anorexia nervosa and vertebral fractures

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Iwamoto J

2011-07-01

Full Text Available Jun Iwamoto1, Yoshihiro Sato2, Mitsuyoshi Uzawa3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Neurology, Mitate Hospital, Fukuoka, Japan; 3Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, JapanAbstract: We report the case of a 30-year-old Japanese woman with anorexia nervosa and vertebral fractures who was treated with etidronate. She had a history of anorexia nervosa, chronic back pain, osteoporosis, and multiple vertebral fractures (morphometric fractures that responded poorly to treatment with alfacalcidol (1 µg daily for 1 year and was treated with cyclical etidronate (200 mg for 2 weeks every 3 months for 7 years. The lumbar spine bone mineral density (BMD increased, and the serum alkaline phosphatase and urinary cross-linked N-terminal telopeptides of type I collagen levels and back pain decreased. During the 7-year period of treatment with etidronate, no osteoporotic fractures occurred. The patient experienced neither renal dysfunction nor hyperparathyroidism caused by osteomalacia. No gastrointestinal tract symptoms were observed. Thus, etidronate was effective for increasing the lumbar spine BMD and reducing back pain over a 7-year period without causing either osteoporotic fractures or adverse events.Keywords: anorexia nervosa, bulimia, etidronate, bone mineral density, osteoporosis, vertebral fracture

Molecular studies of Cs adsorption sites in inorganic layered materials: the influence of solution concentration.

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Sato, Kiminori; Hunger, Michael

2017-07-19

Radioactive Cs released into a soil environment migrates along with groundwater in a manner dependent on Cs concentration. Data on the variation of Cs adsorption as a function of solution concentration are an essential prerequisite to successful decontamination work in Fukushima. To aid the ongoing decontamination work, the adsorption of Cs in aqueous solution across a wide Cs + molarity range is studied for the case of saponite clay as adsorbent, an inorganic layered material that is an abundant mineral in the soil environment. The local molecular structures, i.e. nanosheet surfaces, nanosheet edges, and oncoming hexagonal cavities, participating in Cs adsorption are qualitatively highlighted by means of a recently developed analytical method using data from a conventional elution test, 133 Cs magic-angle-spinning nuclear magnetic resonance (MAS NMR), and the radiocesium interception potential (RIP) [K. Sato, et al., J. Phys. Chem. C, 2016, 120, 1270]. The concentrations of nanosheet edges amount to between 100 and 400 mmol kg -1 , which are not substantially different from those of the nanosheet surfaces, generally regarded as the main decontamination sites. This unambiguously implies that the nanosheet edges should be targeted as the molecular sites for decontaminating radioactive Cs, in addition to the nanosheet surfaces.

Single-leg squats can predict leg alignment in dancers performing ballet movements in “turnout”

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Hopper LS

2016-11-01

Full Text Available Luke S Hopper,1 Nahoko Sato,2 Andries L Weidemann1 1Western Australian Academy of Performing Arts, Edith Cowan University, Mt Lawley, WA, Australia; 2Department of Physical Therapy, Nagoya Gakuin University, Seto, Japan Abstract: The physical assessments used in dance injury surveillance programs are often adapted from the sports and exercise domain. Bespoke physical assessments may be required for dance, particularly when ballet movements involve “turning out” or external rotation of the legs beyond that typically used in sports. This study evaluated the ability of the traditional single-leg squat to predict the leg alignment of dancers performing ballet movements with turnout. Three-dimensional kinematic data of dancers performing the single-leg squat and five ballet movements were recorded and analyzed. Reduction of the three-dimensional data into a one-dimensional variable incorporating the ankle, knee, and hip joint center positions provided the strongest predictive model between the single-leg squat and the ballet movements. The single-leg squat can predict leg alignment in dancers performing ballet movements, even in “turned out” postures. Clinicians should pay careful attention to observational positioning and rating criteria when assessing dancers performing the single-leg squat. Keywords: injury, motion capture, clinical assessment

Audiovisual Capture with Ambiguous Audiovisual Stimuli

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Jean-Michel Hupé

2011-10-01

Full Text Available Audiovisual capture happens when information across modalities get fused into a coherent percept. Ambiguous multi-modal stimuli have the potential to be powerful tools to observe such effects. We used such stimuli made of temporally synchronized and spatially co-localized visual flashes and auditory tones. The flashes produced bistable apparent motion and the tones produced ambiguous streaming. We measured strong interferences between perceptual decisions in each modality, a case of audiovisual capture. However, does this mean that audiovisual capture occurs before bistable decision? We argue that this is not the case, as the interference had a slow temporal dynamics and was modulated by audiovisual congruence, suggestive of high-level factors such as attention or intention. We propose a framework to integrate bistability and audiovisual capture, which distinguishes between “what” competes and “how” it competes (Hupé et al., 2008. The audiovisual interactions may be the result of contextual influences on neural representations (“what” competes, quite independent from the causal mechanisms of perceptual switches (“how” it competes. This framework predicts that audiovisual capture can bias bistability especially if modalities are congruent (Sato et al., 2007, but that is fundamentally distinct in nature from the bistable competition mechanism.

Development of enzyme technology for Aspergillus oryzae, A. sojae, and A. luchuensis, the national microorganisms of Japan.

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Ichishima, Eiji

2016-09-01

This paper describes the modern enzymology in Japanese bioindustries. The invention of Takadiastase by Jokiti Takamine in 1894 has revolutionized the world of industrial enzyme production by fermentation. In 1949, a new γ-amylase (glucan 1,4-α-glucosidase, EC 3.2.1.3) from A. luchuensis (formerly designated as A. awamori), was found by Kitahara. RNase T1 (guanyloribonuclease, EC 3.1.27.3) was discovered by Sato and Egami. Ando discovered Aspergillus nuclease S1 (single-stranded nucleate endonuclease, EC 3.1.30.1). Aspergillopepsin I (EC 3.4.23.18) from A. tubingensis (formerly designated as A. saitoi) activates trypsinogen to trypsin. Shintani et al. demonstrated Asp76 of aspergillopepsin I as the binding site for the basic substrate, trypsinogen. The new oligosaccharide moieties Man10GlcNAc2 and Man11GlcNAc2 were identified with α-1,2-mannosidase (EC 3.2.1.113) from A. tubingensis. A yeast mutant compatible of producing Man5GlcNAc2 human compatible sugar chains on glycoproteins was constructed. The acid activation of protyrosinase from A. oryzae at pH 3.0 was resolved. The hyper-protein production system of glucoamylase was established in a submerged culture.

Resultados da valvoplastia por balão do grupo submetido a plastia mitral percutânea ou cirúrgica prévias com o tratado pela primeira vez: evolução do grupo com plastia prévia Balloon valvuloplasty outcome of a group previously submitted to mitral percutaneous or surgical valve repair versus first-time valvuloplasty patients: evolution of the group previously submitted to valve repair procedures

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Edison Carvalho S. Peixoto

2006-05-01

Full Text Available OBJETIVO: Avaliar 501 procedimentos de valvoplastia mitral e as diferenças entre um grupo já submetido a plastia valvar prévia por balão ou cirúrgica, com 59 procedimentos e um grupo sem intervenção prévia, com 442 procedimentos. MÉTODOS: Foi utilizado balão único em 406 procedimentos, balão de Inoue em 89, e duplo balão em seis, não havendo diferença entre os balões utilizados nos dois grupos (p=0,6610. Estudou-se a evolução a longo prazo dos pacientes com plastia prévia. RESULTADOS: O grupo submetido a plastia valvar prévia era mais velho, com maior escore ecocardiográfico, maior porcentual de pacientes em fibrilação atrial, e dos seus 59 pacientes, 48 tinham sido submetidos à comissurotomia cirúrgica, oito a valvoplastia com balão e três à comissurotomia cirúrgica e à valvoplastia com balão. Os grupos da valvoplastia com plastia valvar prévia e da valvoplastia sem intervenção prévia apresentaram pré-valvoplastia: área valvar mitral ecocardiográfica de 0,99±0,21 e 0,94±0,21 cm² (p=0,0802 e área valvar mitral (Gorlin 0,94±0,18 e 0,91±0,21 cm² (p=0,2518 e área valvar mitral pós-valvoplastia mitral de 1,95±0,44 e 2,05±0,42 cm² (p=0,1059. CONCLUSÕES: O grupo com plastia valvar prévia apresentou o mesmo resultado imediato do grupo sem intervenção prévia. O subgrupo com plastia prévia seguido a longo prazo, apresentou evolução satisfatória.OBJECTIVE: To evaluate 501 procedures of mitral balloon valvuloplasty and the differences among the group already submitted the prior surgical or balloon valvuloplasty, with 59 procedures and the group without previous intervention, with 442 procedures. METHODS: It was used the single balloon in 403, Inoue balloon in 89 and a double balloon in six, with no difference between the 2 groups (p=0.6610. RESULTS: The prior surgical or balloon valvuloplasty group was older, with higher echo score and higher atrial fibrillation rate and of its 59 patients, 48 had

Teaching With Educational Technology in the 21st Century: The Case of The Asian-Pasific Region

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Abdullah KUZU

2006-04-01

Full Text Available Teaching With Educational Technology in the 21st Century: The Case of The Asian-Pasific Region Edited by Yukiko Inoue and Suzanne Bell Hersley: PA: Information Science Publishing, 2006 pp. 321, ISBN 1-59140-724-9 Reviewed by Dr. Abdullah KUZU Anadolu University Eskisehir-TURKEY This book was edited by Yukiko Inoue and Suzanne Bell, an educator and a librarian at the University of Guam, and published by Information Science Publishing in 2006. The book describes the opportunities, challenges and strategies of the technology-enhanced learning in the regional base, namely Asia-Pacific. The main goal of the book is to examine educational technology, learning theories, human learning and cognition; to provide successful experiences in higher education and educational technology; to explain the technology integration into teaching in geographically remote regions such as Guam and Micronesia; to support faculty members in technology use and achieve the reluctance, and to discuss the future trends in educational technology. The book can be recommended for students as well as the professionals such as university professors, researchers, learning center directors, librarians, media specialists, supervisors, and software and courseware designers who are interested in theory and practice of the educational technology, distance education and technology-enhanced learning in multicultural context. ORGANIZATION OF THE SESSIONS The book has nine chapters divided into five sections. Section I contain one chapter and provide an introduction to Guam and Micronesia. The selecting of this region as a case study based on their community that reflects diverse ethnic cultures influenced by European, American, Asian, and Micronesian populations. Guam is a regional learning center in western Pacific. Section II consists of two chapters. Chapter II concentrates on advanced technologies and e-learning, and describes an overview of educational technology, educational media in

TEMPO DE VIABILIDADE DE AMOSTRAS DE SANGUE VENOSO BOVINO DESTINADAS AO EXAME HEMOGASOMÉTRICO, QUANDO MANTIDAS SOB CONSERVAÇÃO EM ÁGUA GELADA VIABILITY TIME OF BLOOD GAS ANALYSIS IN BOVINE VENOUS BLOOD SAMPLES STORED IN ICE WATER BATH

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Júlio Augusto Naylor Lisbôa

2001-04-01

Full Text Available Com o objetivo de verificar o tempo de viabilidade de amostras de sangue venoso bovino destinadas ao exame hemogasométrico, quando conservadas em banho de água gelada, selecionaram-se 14 bovinos (7 machos e 7 fêmeas, clinicamente sadios, entre 1 e 5 anos de idade. Colheram-se, de cada animal, 2 amostras de sangue (10ml cada, por punção da veia jugular, com o emprego de seringas plásticas contendo cerca de 1.000UI de heparina sódica, tomando-se os cuidados de eliminar quaisquer bolhas de gás presentes, e de manter vedada a extremidade da agulha com rolha de borracha. Cada uma do par de seringas foi mantida, distintamente, à temperatura ambiente (entre 23 e 30ºC ou submersa em água gelada (entre zero e 4ºC. As determinações do pH, pressões parciais venosas de dióxido de carbono (PvCO2 e de oxigênio (PvO2, bicarbonato (HCO3-, total de dióxido de carbono (TCO2, excesso ou déficit de bases (BE, bicarbonato padrão (StB, saturação de oxigênio (SatO2 e do conteúdo de oxigênio (O2 foram realizadas imediatamente e com 1, 2, 3, 4, 5, 6, 8, 10, 12 e 24 horas após a colheita. Em cada um dos critérios de manutenção do material, os resultados foram avaliados por meio da análise de variância de medidas repetidas. Consideradas as diferenças entre os valores médios obtidos em cada tempo e aquele da avaliação inicial, os resultados indicaram que as alterações "in vitro" das amostras não conservadas já eram marcantes a partir de 2 ou 3 horas, caracterizando-se por reduções contínuas do pH, PvO2, BE, StB, Sat O2 e O2, e por elevação gradativa da PvCO2. No sangue conservado, ao contrário, o valor de pH não exibiu diferença do original durante as primeiras 4 horas, e os de PvCO2, BE e StB mantiveram-se inalterados por até 6 horas após a colheita. A análise dos resultados permitiu concluir que as amostras de sangue venoso bovino destinadas ao exame de hemogasometria podem permanecer viáveis por até 6 horas, quando

A new curved fault model and method development for asperities of the 1703 Genroku and 1923 Kanto earthquakes

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Kobayashi, R.; Koketsu, K.

2008-12-01

Great earthquakes along the Sagami trough, where the Philippine Sea slab is subducting, have repeatedly occurred. The 1703 Genroku and 1923 (Taisho) Kanto earthquakes (M 8.2 and M 7.9, respectively) are known as typical ones, and cause severe damages in the metropolitan area. The recurrence periods of Genroku- and Taisho-type earthquakes inferred from studies of wave cut terraces are about 200-400 and 2000 years, respectively (e.g., Earthquake Research Committee, 2004). We have inferred the source process of the 1923 Kanto earthquake from geodetic, teleseismic, and strong motion data (Kobayashi and Koketsu, 2005). Two asperities of the 1923 Kanto earthquake are located around the western part of Kanagawa prefecture (the base of the Izu peninsula) and around the Miura peninsula. After we adopted an updated fault plane model, which is based on a recent model of the Philippine Sea slab, the asperity around the Miura peninsula moves to the north (Sato et al., 2005). We have also investigated the slip distribution of the 1703 Genroku earthquake. We used crustal uplift and subsidence data investigated by Shishikura (2003), and inferred the slip distribution by using the same geometry of the fault as the 1923 Kanto earthquake. The peak of slip of 16 m is located the southern part of the Boso peninsula. Shape of the upper surface of the Philippine Sea slab is important to constrain extent of the asperities well. Sato et al. (2005) presented the shape in inland part, but less information in oceanic part except for the Tokyo bay. Kimura (2006) and Takeda et al. (2007) presented the shape in oceanic part. In this study, we compiled these slab models, and planed to reanalyze the slip distributions of the 1703 and 1923 earthquakes. We developed a new curved fault plane on the plate boundary between the Philippine Sea slab and inland plate. The curved fault plane was divided into 56 triangle subfaults. Point sources for the Green's function calculations are located at centroids

Experimental investigations on bubble turbulent diffusion in a vertical large diameter pipe by means of wire-mesh sensors and correlation techniques

International Nuclear Information System (INIS)

Annalisa Manera; Horst-Michael Prasser; Dirk Lucas

2005-01-01

correction consists in deconvolutioning the spatial cross-correlation obtained with the technique described above with the auto-correlation of the gas-fraction distribution measured by the first sensor. It is found that for a given liquid superficial velocity a sudden increase of the diffusion coefficient takes place when the superficial gas velocity is increased above a certain value. For superficial liquid velocities higher than 0.6 m/s the abrupt increase of the diffusion coefficient occurs in correspondence of the transition between wall-peak and center-peak gas-fraction profiles. The experimental diffusion coefficients are compared with the prediction of the Sato's model (experimental gas-fraction profiles and bubble size distributions are given as input). Even if this model has been developed for bubbly flow, satisfactory agreement with the experimental data is found also in the churn-turbulent regime. A detailed discussion on the comparison between experiments and Sato's model is given in the paper. (authors)

SCC and Corrosion Fatigue characterization of a Ti-6Al-4V alloy in a corrosive environment – experiments and numerical models

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S. Baragetti

2014-10-01

Full Text Available In the present article, a review of the complete characterization in different aggressive media of a Ti-6Al-4V titanium alloy, performed by the Structural Mechanics Laboratory of the University of Bergamo, is presented. The light alloy has been investigated in terms of corrosion fatigue, by axial fatigue testing (R = 0.1 of smooth and notched flat dogbone specimens in laboratory air, 3.5% wt. NaCl–water mixture and methanol–water mixture at different concentrations. The first corrosive medium reproduced a marine environment, while the latter was used as a reference aggressive environment. Results showed that a certain corrosion fatigue resistance is found in a salt water medium, while the methanol environment caused a significant drop – from 23% to 55% in terms of limiting stress reduction – of the fatigue resistance of the Ti-6Al-4V alloy, even for a solution containing 5% of methanol. A Stress Corrosion Cracking (SCC experimental campaign at different methanol concentrations has been conducted over slightly notched dog-bone specimens (Kt = 1.18, to characterize the corrosion resistance of the alloy under quasi-static load conditions. Finally, crack propagation models have been implemented to predict the crack propagation rates for smooth specimens, by using Paris, Walker and Kato-Deng-Inoue-Takatsu propagation formulae. The different outcomes from the forecasting numerical models were compared with experimental results, proposing modeling procedures for the numerical simulation of fatigue behavior of a Ti-6Al-4V alloy.

Comparison of the effects of 23-gauge and 25-gauge microincision vitrectomy blade designs on incision architecture

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Inoue M

2014-11-01

Full Text Available Makoto Inoue,1 Dina Joy K Abulon,2 Akito Hirakata1 1Kyorin Eye Center, School of Medicine, Kyorin University, Tokyo, Japan; 2Alcon Research, Ltd., Irvine, CA, USA Purpose: To compare the effects of different 23- and 25-gauge microincision vitrectomy trocar cannula entry systems on incision architecture.Methods: We tested one ridged microvitreoretinal (MVR, one non-ridged MVR, one pointed beveled, and one round-tipped beveled blade (n=10 per blade design per incision type. Each blade’s straight and oblique incision architecture was assessed in a silicone disc simulating the sclera. Wound leakage under pressure and endoscopic observations were conducted on sclerotomy sites of isolated porcine eyes (n=4 per blade design after simulated vitrectomy.Results: Differences in blade design created distinct incision architecture. Incisions were linear with the ridged MVR blade, flattened “M-shaped” with the non-ridged MVR blade, asymmetrical chevron-shaped with the pointed beveled blade, and curved with the round-tipped beveled blade. With the exception of oblique entry incision thickness, both MVR blade designs created thinner incisions than the beveled blades at entry and exit sites. Only the ridged MVR blade created incisions with no leakage. Vitreous incarceration was observed with all trocar cannula systems.Conclusion: Wound closure in porcine eyes was similar with all blades despite differences in incision architecture. Wound leakage occurred at low to moderate infusion pressures with most blades; no wound leakage was observed with ridged MVR blades. Keywords: entry system, incision closure, leakage, pars plana incision, sclerotomy, trocar blade 

Occupational Competence for Improving Industrial Enterprise Competitive Standards / Profesní Kompetence Pro Zlepšení Konkurenčních Standardů Průmyslového Podniku

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Krčmarská Lucie

2013-09-01

Full Text Available Úspěchy firem jsou většinou poměřovány jejich dosaženými výsledky. Za základ těchto úspěchů lze považovat úroveň kompetencí lidí, kteří pro firmu pracují. Kompetence lidí chápeme jako souhrn dosahovaného výkonu a přinášeného potenciálu. Jestliže chybí jedno, pak chybí i kompetence jako celek. Problémy, které vznikají ve firmách můžete tedy převést na chybějící nebo nedostačující kompetence a je tedy nutné doplnit to, co v oblasti kompetencí chybí. Uvědomí-li si firma význam kompetencí lidí ve vztahu k úspěchům nebo neúspěchům a zaměří-li se na jejich rozvoj, odstraňuje tím příčiny vznikajících problémů, ne jen jejich viditelné problémy. Článek je zaměřen na posouzení kompetencí a kompetenčních modelů jako významného nástroje v oblasti řízení lidských zdrojů.

Preventive effects of a phospholipid polymer coating on PMMA on biofilm formation by oral streptococci

Science.gov (United States)

Shibata, Yukie; Yamashita, Yoshihisa; Tsuru, Kanji; Ishihara, Kazuhiko; Fukazawa, Kyoko; Ishikawa, Kunio

2016-12-01

The regulation of biofilm formation on dental materials such as denture bases is key to oral health. Recently, a biocompatible phospholipid polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB) coating, was reported to inhibit sucrose-dependent biofilm formation by Streptococcus mutans, a cariogenic bacterium, on the surface of poly(methyl methacrylate) (PMMA) denture bases. However, S. mutans is a minor component of the oral microbiome and does not play an important role in biofilm formation in the absence of sucrose. Other, more predominant oral streptococci must play an indispensable role in sucrose-independent biofilm formation. In the present study, the effect of PMB coating on PMMA was evaluated using various oral streptococci that are known to be initial colonizers during biofilm formation on tooth surfaces. PMB coating on PMMA drastically reduced sucrose-dependent tight biofilm formation by two cariogenic bacteria (S. mutans and Streptococcus sobrinus), among seven tested oral streptococci, as described previously [N. Takahashi, F. Iwasa, Y. Inoue, H. Morisaki, K. Ishihara, K. Baba, J. Prosthet. Dent. 112 (2014) 194-203]. Streptococci other than S. mutans and S. sobrinus did not exhibit tight biofilm formation even in the presence of sucrose. On the other hand, all seven species of oral streptococci exhibited distinctly reduced glucose-dependent soft biofilm retention on PMB-coated PMMA. We conclude that PMB coating on PMMA surfaces inhibits biofilm attachment by initial colonizer oral streptococci, even in the absence of sucrose, indicating that PMB coating may help maintain clean conditions on PMMA surfaces in the oral cavity.

Consideration of therapeutic approach to advanced colorectal cancer in elderly patients

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Yasuhiro Inoue

2014-02-01

Full Text Available Colorectal cancer (CRC is predominantly a disease of elderly and is a major cause of morbidity and mortality in the elderly population. The increased availability of treatment options for CRC has made it more difficult for clinicians to decide on the optimal therapeutic approach in elderly patients, because of the potential for poorer outcomes due to an increased burden of comorbidities, functional dependency, and limited life expectancy. It is necessary to determine which elderly patients are likely to benefit from active cancer therapy, and the establishment of treatment markers for multimodality approaches is eagerly awaited. Elderly cancer patients are at risk of exposure to various intrinsic inflammatory mediators, such as tumor-generating cytokines and surgery-induced pro-inflammatory cytokines. It is therefore important to understand the immunological changes occurring in the elderly and to adjust treatment strategies accordingly to reduce the morbidity and mortality associated with multimodality therapy for CRC that induce systemic inflammation. Several inflammation-based factors such as the Glasgow Prognostic Score (GPS may reflect the balance between tumor progression and host-related immunity, especially in elderly CRC patients. Appropriate selection criteria for multimodality therapy in elderly CRC patients may include not only tumor characteristics, but also host- and/or treatment-related factors such as comorbidities or surrogate markers using inflammation-based factors.----------------------------------------------Cite this article as: Inoue Y, Toiyama Y, Tanaka K, Mohri Y, Kusunoki M. Consideration of therapeutic approach to advanced colorectal cancer in elderly patients. Int J Cancer Ther Oncol 2014; 2(1:02014.DOI: http://dx.doi.org/10.14319/ijcto.0201.4

Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease

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Barbara Tate

2012-01-01

Full Text Available The Amyloid Hypothesis states that the cascade of events associated with Alzheimer's disease (AD—formation of amyloid plaques, neurofibrillary tangles, synaptic loss, neurodegeneration, and cognitive decline—are triggered by Aβ peptide dysregulation (Kakuda et al., 2006, Sato et al., 2003, Qi-Takahara et al., 2005. Since γ-secretase is critical for Aβ production, many in the biopharmaceutical community focused on γ-secretase as a target for therapeutic approaches for Alzheimer's disease. However, pharmacological approaches to control γ-secretase activity are challenging because the enzyme has multiple, physiologically critical protein substrates. To lower amyloidogenic Aβ peptides without affecting other γ-secretase substrates, the epsilon (ε cleavage that is essential for the activity of many substrates must be preserved. Small molecule modulators of γ-secretase activity have been discovered that spare the ε cleavage of APP and other substrates while decreasing the production of Aβ42. Multiple chemical classes of γ-secretase modulators have been identified which differ in the pattern of Aβ peptides produced. Ideally, modulators will allow the ε cleavage of all substrates while shifting APP cleavage from Aβ42 and other highly amyloidogenic Aβ peptides to shorter and less neurotoxic forms of the peptides without altering the total Aβ pool. Here, we compare chemically distinct modulators for effects on APP processing and in vivo activity.

Quantitative relationship between VLF phase deviations and 1-8 A solar X-ray fluxes during solar flares

Energy Technology Data Exchange (ETDEWEB)

Muraoka, Y; Murata, H; Sato, T [Hyogo Coll. Of Medicine (Japan). Dept. of Physics

1977-07-01

An attempt is made to investigate the quantitative relationship between VLF phase deviations in SPA (sudden phase anomalies) events and associated solar X-ray fluxes in the 1 to 8 A band during solar flares. The phase deviations (..delta..phi) of the 18.6 kHz VLF wave transmitted from NLK, USA are used in this analysis which were recorded at Nishinomiya, Japan during the period June 1974 to May 1975. The solar X-ray fluxes (F/sub 0/) in the 1 to 8 A band are estimated from fsub(min) variations using the empirical expression given by Sato (J.Geomag.Geoelectr.;27: 95(1975)), because no observed data were available on the 1 to 8 a X-ray fluxes during the period of the VLF observation. The result shows that the normalized phase variation, ..delta..phi/coschisub(min), where chisub(min) represents the minimum solar zenith angle on the VLF propagation path, increases with increasing logF/sub 0/. A theoretical explanation for this is presented assuming that enhanced ionizations produced in the lower ionosphere by a monochromatic solar X-ray emission are responsible for the VLF phase deviations. Also it is found that a threshold X-ray flux to produce a detectable SPA effect is approximately 1.5 x 10/sup -3/ cm/sup -2/ sec/sup -1/ in the 1 to 8 a band.

Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease

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Osamu Kano

2009-02-01

Full Text Available Osamu Kano1,2, Ken Ikeda2, Tetsuhito Kiyozuka2, Konosuke Iwamoto2, Hirono Ito2, Yuji Kawase2, Ryuta Sato2, Toshiki Fujioka2, Yo Araki2, Shigeji Baba2, Yasuo Iwasaki21Department of Neurology, Methodist Neurological Institute, Houston, TX, USA; 2Department of Neurology, Toho University Omori Medical Center, Tokyo, JapanAbstract: We examined whether pramipexole (PPX can influence depressive scale in normal and mild depressive parkinsonian patients. In an open study of PPX as an add-on to L-dopa therapy or single administration, 36 nondemented outpatients with Parkinson’s disease (PD were entered first. All were in the stage II or III of Hoehn and Yahr scale (H&Y. PPX were started at 0.125 mg/day and daily doses were increased to 1.5 mg/day. At 3 months after PPX treatment, patients were re-evaluated. Hamilton Depression Rating Scale (HAM-D, Unified Parkinson’s Disease Rating Scale III, H&Y stage, and freezing of gait questionnaire were compared in patients before and after PPX treatment. These scores were significantly improved after PPX administration. There were no correlations between HAM-D and those motor functions. We suggest that PPX treatment has antidepressant effects in depressive PD patients and also ameliorates HAM-D score in nondepressive PD patients in addition to motor function.Keywords: Parkinson disease, pramipexole, motor function, depression, antidepressant effect

Five-year follow-up of a woman with pregnancy and lactation-associated osteoporosis and vertebral fractures

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Sato Y

2012-04-01

Full Text Available Jun Iwamoto1, Yoshihiro Sato2, Mitsuyoshi Uzawa3, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, 2Department of Neurology, Mitate Hospital, Fukuoka, 3Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, JapanAbstract: We report the 5-year follow-up of a young woman who developed vertebral fractures after pregnancy and lactation and was treated with active vitamin D hormone. A 32-year-old Japanese woman consulted us because of acute lower back pain caused by L2 and L5 vertebral fractures after pregnancy and lactation. Following cessation of breast-feeding, analgesia, bed rest, and wearing of a hard brace, her lower back pain disappeared within 2 months. After 5 years of treatment with alfacalcidol 1 µg daily, the lumbar spine (L1, L3, L4 bone mineral density increased by 21.4% following vigorous reductions in bone turnover markers. No osteoporotic fractures occurred, and the vertebral fractures healed. The patient experienced no side effects, including hypercalcemia. Thus, the present case report shows long-term changes in bone turnover markers and lumbar spine bone mineral density, as well as long-term safety of alfacalcidol treatment in a young woman with pregnancy and lactation-associated osteoporosis and vertebral fractures.Keywords: young woman, pregnancy, alfacalcidol, bone mineral density, osteoporosis, vertebral fracture

A simple reliability block diagram method for safety integrity verification

International Nuclear Information System (INIS)

Guo Haitao; Yang Xianhui

2007-01-01

IEC 61508 requires safety integrity verification for safety related systems to be a necessary procedure in safety life cycle. PFD avg must be calculated to verify the safety integrity level (SIL). Since IEC 61508-6 does not give detailed explanations of the definitions and PFD avg calculations for its examples, it is difficult for common reliability or safety engineers to understand when they use the standard as guidance in practice. A method using reliability block diagram is investigated in this study in order to provide a clear and feasible way of PFD avg calculation and help those who take IEC 61508-6 as their guidance. The method finds mean down times (MDTs) of both channel and voted group first and then PFD avg . The calculated results of various voted groups are compared with those in IEC61508 part 6 and Ref. [Zhang T, Long W, Sato Y. Availability of systems with self-diagnostic components-applying Markov model to IEC 61508-6. Reliab Eng System Saf 2003;80(2):133-41]. An interesting outcome can be realized from the comparison. Furthermore, although differences in MDT of voted groups exist between IEC 61508-6 and this paper, PFD avg of voted groups are comparatively close. With detailed description, the method of RBD presented can be applied to the quantitative SIL verification, showing a similarity of the method in IEC 61508-6

Analysis of Program Obfuscation Schemes with Variable Encoding Technique

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Fukushima, Kazuhide; Kiyomoto, Shinsaku; Tanaka, Toshiaki; Sakurai, Kouichi

Program analysis techniques have improved steadily over the past several decades, and software obfuscation schemes have come to be used in many commercial programs. A software obfuscation scheme transforms an original program or a binary file into an obfuscated program that is more complicated and difficult to analyze, while preserving its functionality. However, the security of obfuscation schemes has not been properly evaluated. In this paper, we analyze obfuscation schemes in order to clarify the advantages of our scheme, the XOR-encoding scheme. First, we more clearly define five types of attack models that we defined previously, and define quantitative resistance to these attacks. Then, we compare the security, functionality and efficiency of three obfuscation schemes with encoding variables: (1) Sato et al.'s scheme with linear transformation, (2) our previous scheme with affine transformation, and (3) the XOR-encoding scheme. We show that the XOR-encoding scheme is superior with regard to the following two points: (1) the XOR-encoding scheme is more secure against a data-dependency attack and a brute force attack than our previous scheme, and is as secure against an information-collecting attack and an inverse transformation attack as our previous scheme, (2) the XOR-encoding scheme does not restrict the calculable ranges of programs and the loss of efficiency is less than in our previous scheme.

Perceiving Direction of a Walker: Effect of Body Appearance

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Kazuya Ono

2011-05-01

Full Text Available Human can perceive others' walking direction accurately even with 117ms observation (Sato, et al., ECVP2008. We aimed to see whether appearance of walker's body affects the accuracy of perceiving direction of the walker. Thus, we employed three different appearances: realistic human computer-graphics body (CG-human, nonrealistic cylinder-assembled body (Cylinders, and point-light walker (Points. We made a three-dimensional model of an adult-size walker who walked at a place. CG-human stimuli were generated by rendering the model with smooth shading. We made Cylinders stimuli by replacing body parts such as arms, legs, head, and hands with cylinders. Points stimuli were made by tracking 18 positions (mostly joints of the body like biological motion. One of walkers was presented for 117, 250, 500 or 1000ms while its direction was randomly varied by 3deg steps to 21deg left or right. Observers judged whether the walker was walking toward them (hit or not (miss, and self-range was measured in terms of the standard deviation for hit distributions. The perceived self-range was narrowed with long duration, and with CG-human stimulus. It is suggested that the accuracy of perceiving walker's direction depends on body appearance, and it is higher for human-like body than nonhuman body.

Osteodystrophy in liver cirrhosis

International Nuclear Information System (INIS)

Sezai, Shu-ichi; Ishizawa, Suguru; Yoshino, Katsumasa

1987-01-01

In order to investigate the osteodystrophy in liver cirrhosis, 21 liver cirrhotic patients having no malignancy and normal renal function were examined by 99m Tc Methylene Diphosphonate (MDP) bone scintigraphy. The cirrhotic subjects consisted of 14 males and 7 females. Their age was 31 - 80, average 55.7 years. The causes of their cirrhotic damage were 1 primary biliary cirrhosis, 9 alcoholic, 2 HB viral and 9 cryptogenic. The contents of their illness showed 9 cases in A, 4 in B and 8 in C of Child's classification. Abnormal hot spot(s) on bone in the cirrhotics could be observed very frequently in 99m Tc MDP bone scintigraphy (47.6 %; 10/21 cases). Those spots were seen more frequently in female and advanced stage of cirrhosis. The number of spot(s) increased also in advanced liver cirrhosis. Serum Ca, P and PTH were in normal range. All of three vitamin D 3 fractions decreased and especially 1,25 (OH) 2 D 3 was depressed more in scinti-positive cases. Metacarpal bone X-p with an alumimum step wedge as a reference was analyzed by a microdensitometry (MD) method (Inoue T et al) and the pattern of osteopathy (i.e. porosis, malacia and poromalacia) was examined according to Sumi Y et al. MD method was not known yet if there was any definite correlation with bone scintigraphy and the osteopathic pattern belonged to border categories. In conclusion, more attension on hepatic osteodystrophy will be significantly necessary due to the fact that it has been found very frequently in liver cirrhosis. 99m Tc MDP bone scintigraphy is a good means for detection of the hepatic osteodystrophy. (author)

First case of fungal keratitis caused by Pestalotiopsis clavispora

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Monden Y

2013-11-01

Full Text Available Yu Monden,1 Shohaku Yamamoto,1 Ryoji Yamakawa,1 Atsuko Sunada,2 Seishi Asari,3 Koichi Makimura,4 Yoshitsugu Inoue5 1Department of Ophthalmology, Kurume University School of Medicine, Fukuoka, 2Laboratory for Clinical Investigation, 3Department of Infection Control and Prevention, Osaka University Hospital, Osaka, 4Teikyo University Institute of Medical Mycology, Tokyo, 5Division of Ophthalmology and Visual Sciences, Tottori University Faculty of Medicine, Tottori, Japan Purpose: To report the isolation of Pestalotiopsis clavispora from the cornea of a patient with recurrent keratitis. Case report: A 73-year-old male gardener presented with conjunctival injection and an oval infiltrate with feathery margins in the temporal half of the cornea in the right eye. His ocular history in the right eye included cataract surgery, five episodes of herpes simplex keratitis, three glaucoma surgeries, and bullous keratopathy. He had been treated with corticosteroids for years. Light microscopy of corneal scrapings revealed a filamentous fungus, and fungal keratitis was diagnosed. Treatment with topical voriconazole and pimaricin ointment was commenced. One month later, the infiltrate resolved. The antifungal agents were discontinued 7 months later, and keratitis relapsed 4 days after the discontinuation. The fungus was isolated and identified by molecular techniques as P. clavispora. Based on the results of antifungal susceptibility testing, treatment with topical and intravenous micafungin was initiated. The corneal infiltrate resolved 1 month after the relapse. Conclusion: Molecular identification of the pathogen, and antifungal susceptibility testing, are useful in treating patients with fungal keratitis caused by a rare human pathogen. Keywords: fungal keratitis, Pestalotiopsis clavispora, plant pathogen, molecular identification, antifungal susceptibility test

Zeolitization of intracaldera sediments and rhyolitic rocks in the 1.25 Ma lake of Valles caldera, New Mexico, USA

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Chipera, Steve J.; Goff, Fraser; Goff, Cathy J.; Fittipaldo, Melissa

2008-12-01

Quantitative X-ray diffraction analysis of about 80 rhyolite and associated lacustrine rocks has characterized previously unrecognized zeolitic alteration throughout the Valles caldera resurgent dome. The alteration assemblage consists primarily of smectite-clinoptilolite-mordenite-silica, which replaces groundmass and fills voids, especially in the tuffs and lacustrine rocks. Original rock textures are routinely preserved. Mineralization typically extends to depths of only a few tens of meters and resembles shallow "caldera-type zeolitization" as defined by Utada et al. [Utada, M., Shimizu, M., Ito, T., Inoue, A., 1999. Alteration of caldera-forming rocks related to the Sanzugawa volcanotectonic depression, northeast Honshu, Japan — with special reference to "caldera-type zeolitization." Resource Geol. Spec. Issue No. 20, 129-140]. Geology and 40Ar/ 39Ar dates limit the period of extensive zeolite growth to roughly the first 30 kyr after the current caldera formed (ca. 1.25 to 1.22 Ma). Zeolitic alteration was promoted by saturation of shallow rocks with alkaline lake water (a mixture of meteoric waters and degassed hydrothermal fluids) and by high thermal gradients caused by cooling of the underlying magma body and earliest post-caldera rhyolite eruptions. Zeolitic alteration of this type is not found in the later volcanic and lacustrine rocks of the caldera moat (≤ 0.8 Ma) suggesting that later lake waters were cooler and less alkaline. The shallow zeolitic alteration does not have characteristics resembling classic, alkaline lake zeolite deposits (no analcime, erionite, or chabazite) nor does it contain zeolites common in high-temperature hydrothermal systems (laumontite or wairakite). Although aerially extensive, the early zeolitic alteration does not form laterally continuous beds and are consequently, not of economic significance.

Viral vectors for cystic fibrosis gene therapy: What does the future hold?

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Uta Griesenbach

2010-12-01

Full Text Available Uta Griesenbach1, Makoto Inoue2, Mamoru Hasegawa2, Eric WFW Alton11Department of Gene Therapy, Imperial College London, UK; The UK Cystic Fibrosis Gene Therapy Consortium; 2DNAVEC Corporation, Tsukuba, JapanAbstract: Gene transfer to the airway epithelium has been more difficult than originally anticipated, largely because of significant extra- and intracellular barriers in the lung. In general, viral vectors are more adapted to overcoming these barriers than nonviral gene transfer agents and are, therefore, more efficient in transferring genes into recipient cells. Viral vectors derived from adenovirus, adeno-associated virus, and Sendai virus, which all have a natural tropism for the airway epithelium, have been evaluated for cystic fibrosis (CF gene therapy. Although these vectors transduce airway epithelial cells efficiently, gene expression is transient and repeated administration is inefficient. They are, therefore, unlikely to be suitable for CF gene therapy. More recently, lentiviruses (LV have been assessed for lung gene transfer. In contrast to retroviruses, they transduce nondividing cells and randomly integrate into the genome. However, LVs do not have a natural tropism for the lung, and a significant amount of effort has been put into pseudotyping these vectors with proteins suitable for airway gene transfer. Several studies have shown that LV-mediated transduction leads to persistent gene expression (for the lifetime of the animal in the airways and, importantly, repeated administration is feasible. Thus, appropriately pseudotyped LV vectors are promising candidates for CF gene therapy. Here, we will review preclinical and clinical research related to viral CF gene therapy.Keywords: cystic fibrosis, gene therapy, adenovirus, AAV, lentivirus, Sendai virus

Moisture removal of paddy by agricultural residues: basic physical parameters and drying kinetics modeling

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Saniso, E.

2007-05-01

Full Text Available The objectives of this research were to study basic physical parameters of three agricultural residues that could be used for prediction of paddy drying kinetics using desiccants, to investigate a suitable methodfor moisture reduction of fresh paddy using 3 absorbents, and to modify the drying model of Inoue et al. for determining the evolution of moisture transfer during the drying period. Rice husk, sago palm rachis andcoconut husk were used as moisture desiccants in these experiments. From the results, it was concluded that the apparent density of all adsorbents was a linear function of moisture content whilst an equilibriummoisture content equation following Hendersonís model gave the best fit to the experimental results. From studying the relationship between moisture ratio and drying time under the condition of drying temperaturesof 30, 50 and 70oC, air flow rate of 1.6 m/s and initial moisture content of absorbents of 15, 20 and 27% dry-basis, it was shown that the moisture ratio decreased when drying time increased. In addition, thethin-layer desiccant drying equation following of the Page model can appropriately explain the evolution of moisture content of paddy over the drying time. The diffusion coefficient of all absorbents, which was in therange of 1x10-8 to 6x10-8 m2/h, was relatively dependent on drying temperature and inversely related to drying time. The diffusivity of coconut husk had the highest value compared to the other absorbents.The simulating modified mathematical model to determine drying kinetics of paddy using absorption technique and the simulated results had good relation to the experimental results for all adsorbents.

Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells*

Science.gov (United States)

Yamaoka, Kaoru; Inoue, Masayuki; Miyazaki, Keisuke; Hirama, Masahiro; Kondo, Chie; Kinoshita, Eiji; Miyoshi, Hiroshi; Seyama, Issei

2009-01-01

The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Nav1.2, Nav1.4, and Nav1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M. (2004) Br. J. Pharmacol. 142, 879–889). In this study, we further explored the effects of CTX3C on the TTX-resistant sodium channel Nav1.8. TTX-resistant channels have been shown to be involved in transducing pain and related sensations (Akopian, A. N., Sivilotti, L., and Wood, J. N. (1996) Nature 379, 257–262). Thus, we hypothesized that ciguatoxin-induced activation of the Nav1.8 current would account for the neurological symptoms of ciguatera poisoning. We found that 0.1 μm CTX3C preferentially affected the activation process of the Nav1.8 channel compared with those of the Nav1.2 and Nav1.4 channels. Importantly, without stimulation, 0.1 μm CTX3C induced a large leakage current (IL). The conductance of the IL calculated relative to the maximum conductance (Gmax) was 10 times larger than that of Nav1.2 or Nav1.4. To determine the molecular domain of Nav1.8 responsible for conferring higher sensitivity to CTX3C, we made two chimeric constructs from Nav1.4 and Nav1.8. Chimeras containing the N-terminal half of Nav1.8 exhibited a large response similar to wild-type Nav1.8, indicating that the region conferring high sensitivity to ciguatoxin action is located in the D1 or D2 domains. PMID:19164297

Textura de goiabas "Pedro Sato" submetidas à aplicação de cloreto de cálcio Texture of “Pedro Sato” guavas submitted to the application of calcium cloride

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Andréa Luiza Ramos Pereira Xisto

2004-02-01

Full Text Available Entre as técnicas utilizadas para manter a qualidade pós-colheita de frutos, destaca-se a aplicação de cálcio, geralmente associada à refrigeração. No entanto, nem todos os produtores têm acesso a câmaras frias; portanto, objetivou-se neste trabalho avaliar o tratamento isolado com cloreto de cálcio na manutenção da aparência de goiabas (Psidium guajava L. destinadas ao consumo “in natura”, armazenadas em condições ambientes. O tratamento hidrotérmico à temperatura de 30ºC com cloreto de cálcio a 1g/100 mL (CCa foi testado, comparando-o com frutos sem tratamento (SCa. Em seguida, os frutos foram armazenadas em condições ambientes (22,6ºC ± 1, UR 75% ± 5 durante quatro dias. Após o armazenamento, avaliaram-se os teores de pectina total e solúvel e as atividades de pectinametilesterase e poligalacturonase. O emprego de cálcio afetou as características analisadas, proporcionando menores teores de pectina solúvel e atividades mais baixas de pectinametilesterase e poligalacturonase, promovendo um amaciamento menos intenso e mantendo a firmeza desses frutos durante o período de armazenamento.Among the techniques used to maintain the post-harvest quality of fruits, stands out the application of calcium, usually associated to the refrigeration. However, not all the producers have access to cold cameras, therefore it was aimed at in this work, to evaluate the isolated treatment with calcium chloride in the maintenance of the appearance of guavas (Psidium guajava L. destined to the consumption “in nature”, stored in environmental conditions. The hydrothermical treatment at the temperature of 30ºC, with calcium chloride 1g/100 mL, was tested comparing with fruits without treatment. Soon after the fruits were stored under environmental conditions (22,6ºC (±1, UR 75% (±5 for four days. After the storage, the contents of total and soluble pectin and the pectinametilesterase and poligalacturonase activities were evaluated. The employment of calcium affected the analyzed characteristics providing smaller content of soluble pectin and lower activities of pectinametilesterase and poligalacturonase, promoting a less intense softening, maintaining the firmness of the fruits during the storage period.

ANESTESIA EM EQÜINOS COM DETOMIDINA E TILETAMINA-ZOLAZEPAM

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Cláudio Corrêa Natalini

1994-01-01

Full Text Available RESUMO Seis eqüinos foram anestesiados, via intravenosa, com o cloridrato de detomidina 1% (0,03mg/kg, associado à combinação tiletamina-zolazepam 5% (1mg/kg. Foram registrados o tempo para obtenção do decúbito lateral e o tempo para retorno à posição de estação. As freqüências cardíaca e respiratória, a temperatura retal, os vaiores arteriais de pH, PCO2, PO2, HCO3, excesso de bases e SATO2, foram analisados no período anterior à sedação (valor basal, durante a anestesia e ao retorno à posição de estação. Dois eqüinos foram submetidos a procedimentos cirúrgicos. O tempo médio para a obtenção do decúbito lateral foi de 53,80 ± 9,06 segundos. O período médio em decúbito lateral foi de 28,50 ± 5,05 minutos e o tempo para retorno à estação foi de 39,16 ± 4,59 minutos. A análise hemogasométrica arterial revelou a ocorrência de hipoxemia no período anestésico. As freqüências cardíaca, respiratória e temperatura retal mantiveram-se estáveis no período estudado.

Is everything clear about Tako-tsubo syndrome?

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Petrov, Ivo S; Tokmakova, Mariya P; Marchov, Daniel N; Kichukov, Kostadin N

2011-01-01

Tako-tsubo syndrome is a novel cardio-vascular disease affecting predominantly postmenopausal women exposed to unexpected strong emotional or physical stress, in the absence of significant coronary heart disease. It is characterized by acute onset of severe chest pain and/or acute left ventricular failure, ECG-changes, typical left ventricular angiographic findings, good prognosis and positive resolution of the morphological and clinical manifestations. First described in 1990 in Japan by Sato, Tako-tsubo cardiomyopathy is characterized by transient contractile abnormalities of the left ventricle, causing typical left ventricular apical ballooning at end-systole with concomitant compensatory basal hyperkinesia. There are also atypical forms, presenting with left ventricular systolic dysfunction which affects the mid-portions of the left ventricle. The etiology of the disease still remains unclear. Many theories have been put forward about the potential underlying pathophysiological mechanisms that may trigger this syndrome among which are the theory of catecholamine excess, the theory of multivessel coronary vasospasm, the ischemic theory, and the theory of microvascular dysfunction and dynamic left ventricular gradient induced by elevated circulating catecholamine levels. Adequate management of Tako-tsubo syndrome demands immediate preparation for coronary angiography. Once the diagnosis is made, treatment is primarily symptomatic and includes monitoring for complications. Patients with Tako-tsubo syndrome most frequently develop acute LV failure, pulmonary edema, rhythm and conductive disturbances and apical thrombosis. Treatment is symptomatic and includes administration of diuretics, vasodilators and mechanical support of circulation with intra-aortic balloon counterpulsation.

ADHD performance reflects inefficient but not impulsive information processing: a diffusion model analysis.

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Metin, Baris; Roeyers, Herbert; Wiersema, Jan R; van der Meere, Jaap J; Thompson, Margaret; Sonuga-Barke, Edmund

2013-03-01

Attention-deficit/hyperactivity disorder (ADHD) is associated with performance deficits across a broad range of tasks. Although individual tasks are designed to tap specific cognitive functions (e.g., memory, inhibition, planning, etc.), these deficits could also reflect general effects related to either inefficient or impulsive information processing or both. These two components cannot be isolated from each other on the basis of classical analysis in which mean reaction time (RT) and mean accuracy are handled separately. Seventy children with a diagnosis of combined type ADHD and 50 healthy controls (between 6 and 17 years) performed two tasks: a simple two-choice RT (2-CRT) task and a conflict control task (CCT) that required higher levels of executive control. RT and errors were analyzed using the Ratcliff diffusion model, which divides decisional time into separate estimates of information processing efficiency (called "drift rate") and speed-accuracy tradeoff (SATO, called "boundary"). The model also provides an estimate of general nondecisional time. Results were the same for both tasks independent of executive load. ADHD was associated with lower drift rate and less nondecisional time. The groups did not differ in terms of boundary parameter estimates. RT and accuracy performance in ADHD appears to reflect inefficient rather than impulsive information processing, an effect independent of executive function load. The results are consistent with models in which basic information processing deficits make an important contribution to the ADHD cognitive phenotype. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Numerical simulation of global formation of auroral arcs

International Nuclear Information System (INIS)

Miura, A.; Sato, T.

1980-01-01

Global simulation of auroral arcs is performed, based on the feedback theory of auroral arcs (Sato, 1978), for a three-dimensionally coupled ionosphere-magnetosphere system which includes two pairs of large-scale Birkeland currents, large-scale polar cap electric fields, and a day-night asymmetry of the electron density distribution. Simulation results have shown that auroral arcs are formed in the dark sector of the auroral oval, more preferentially in the evening sector. They usually appear in multiples with a shape elongating in the east-west direction, each arc being a couple of thousand kilometers in length and 10 to 40 km in width. A pair of small-scale, upward and downward, Birkeland currents is associated with each arc, the density of which becomes 10 to 200 μA/m 2 at 110-km height, and the intensity of the associated electrojet reaches 5 to 20 kA. Each arc is strongly polarized in the direction of the large-scale northsouth current so that the electric field inside the arc is reduced considerably from its ambient value. What controls the formation of auroral arcs (growing speed, locations, arc width, etc.) is examined in detail. For example, the arc width becomes sharper, as the bounce time of the Alfven wave decreases. The overall structure of auroras is largely dependent upon the large-scale Birkeland current, the electric field, and the electron density distribution in the auroral oval

Visualized study on specific points on demand curves and flow patterns in a single-side heated narrow rectangular channel

International Nuclear Information System (INIS)

Wang Junfeng; Huang Yanping; Wang Yanlin

2011-01-01

Highlights: → Specific points on the demand curve and flow patterns are visually studied. → Bubbly, churn, and annular flows were observed. → Onset of flow instability and bubbly-churn transition occurs at the same time. → The evolution of specific points and flow pattern transitions were examined. - Abstract: A simultaneous visualization and measurement study on some specific points on demand curves, such as onset of nucleate boiling (ONB), onset of significant void (OSV), onset of flow instability (OFI), and two-phase flow patterns in a single-side heated narrow rectangular channel, having a width of 40 mm and a gap of 3 mm, was carried out. New experimental approaches were adopted to identify OSV and OFI in a narrow rectangular channel. Under experimental conditions, the ONB could be predicted well by the Sato and Matsumura model. The OSV model of Bowring can reasonably predict the OSV if the single-side heated condition is considered. The OFI was close to the saturated boiling point and could be described accurately by Kennedy's correlation. The two-phase flow patterns observed in this experiment could be classified into bubbly, churn, and annular flow. Slug flow was never observed. The OFI always occurred when the bubbles at the channel exit began to coalesce, which corresponded to the beginning of the bubbly-churn transition in flow patterns. Finally, the evolution of specific points and flow pattern transitions were examined in a single-side heated narrow rectangular channel.

Chronic intradiploic hematomas of the skull without coagulopathy: Report of two cases.

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Tokmak, Mehmet; Ozek, Erdinc; Iplikçioğlu, Celal

2015-01-01

Chronic intradiploic hematoma was first described by Chorbski and Davis in 1934. To date, only twelve cases have been reported in the literature. Chronic intradiploic hematomas have also been described as non-neoplastic cysts of the diploe, traumatic cysts, and giant cell repetitive granulomas. The term chronic intradiploic hematoma was coined by Sato et al. in 1994. Case 1: a 16-year-old male presented with a non-tender scalp swelling on the right fronto-orbital region. Computed tomography (CT) scans showed an intraosseous isodense lesion with surrounding sclerosis. Magnetic resonance imaging (MRI) results revealed an intradiploic mass with homogeneous cystic and abnormal signal intensities. Case 2: a 64-year-old male presented with a 6-month history of headaches and visual disturbances. CT scans showed an isodense lesion with surrounding sclerosis in the posterolateral left orbit. MRI results revealed a hypointense lesion on both the T1weighted and T2-weighted images of the posterolateral left orbit. Although rarely seen, the presence of a benign chronic hematoma should be considered as part of the differential diagnosis for each intradiploic mass lesion. When taking the medical history, all patients with such mass lesions should be asked about previous minor or major head traumas. Due to the possibility of progressive growth, surgical excision of an intradiploic hematoma is recommended after radiological diagnosis of the condition. Copyright © 2014 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies

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Sato A

2015-04-01

Full Text Available Akinori Sato Department of Urology, National Defense Medical College, Tokorozawa, Japan Abstract: The human immunodeficiency virus protease inhibitor ritonavir has recently been shown to have antineoplastic activity, and its use in urological malignancies is under investigation with an eye toward drug repositioning. Ritonavir is thought to exert its antineoplastic activity by inhibiting multiple signaling pathways, including the Akt and nuclear factor-kappaB pathways. It can increase the amount of unfolded proteins in the cell by inhibiting both the proteasome and heat shock protein 90. Combinations of ritonavir with agents that increase the amount of unfolded proteins, such as proteasome inhibitors, histone deacetylase inhibitors, or heat shock protein 90 inhibitors, therefore, induce endoplasmic reticulum stress cooperatively and thereby kill cancer cells effectively. Ritonavir is also a potent cytochrome P450 3A4 and P-glycoprotein inhibitor, increasing the intracellular concentration of combined drugs by inhibiting their degradation and efflux from cancer cells and thereby enhancing their antineoplastic activity. Furthermore, riotnavir’s antineoplastic activity includes modulation of immune system activity. Therapies using ritonavir are thus an attractive new approach to cancer treatment and, due to their novel mechanisms of action, are expected to be effective against malignancies that are refractory to current treatment strategies. Further investigations using ritonavir are expected to find new uses for clinically available drugs in the treatment of urological malignancies as well as many other types of cancer. Keywords: drug repositioning, novel treatment

Military aspect of nuclear policy of Japan

International Nuclear Information System (INIS)

Fujita, Yuko

2011-01-01

Military aspect of nuclear policy of Japan was outlined. In 1952 Prime Minister Yoshida asked to prepare production of weapons for rearmament and to establish Science and Technology Agency such as to overcome lack of science research budget and inefficiency of research and cooperation. Kaya and Fushimi proposed establishment of Atomic Energy Commission as recommendation of Science Council of Japan. In 1954 Nakasone proposed budget for nuclear energy with yen 235 million to construct reactor. In 1955 Japanese delegation participated in international conference on peaceful use of nuclear energy at Geneva and nonpartisan members proposed Atomic Energy Basic Law, which limited the use of nuclear technology to peaceful purposes, ensured three principles - democratic methods, independent management, and transparency - as the basis of nuclear research and promoted international co-operation. In 1956 Atomic Energy Commission and Science and Technology Agency were established with other organizations under this law. According to internal report in the age of Prime Minister Sato, nuclear policy in Japan would be (1) no holding nuclear weapon for the time being, (2) maintaining economic and technical potential of nuclear weapon production and (3) considering no restraint for this policy whether Japan participated in NPT or not. Fuel cycle program of Monju reactor and reprocessing for power production seemed to be deployed corresponding to (3) above. Irradiated blanket of Monju reactor could be reprocessed to produce highly purified plutonium suited for nuclear bombs. (T. Tanaka)

GRAVI-2 space experiment: investigating statoliths displacement and location effects on early stages of gravity perception pathways in lentil roots.

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Bizet, François; Eche, Brigitte; Pereda Loth, Veronica; Badel, Eric; Legue, Valerie; Brunel, Nicole; Label, Philippe; Gérard, Joëlle

2016-07-01

The plants ability to orient their growth with respect to external stimuli such as gravity is a key factor for survival and acclimation to their environment. Belowground, plant roots modulate their growth towards gravity, allowing soil exploration and uptake of water and nutrients. In roots, gravity sensing cells called statocytes are located in the center of the root cap. Statocytes contain starch-filled plastids denser than the cytoplasm, which sedimentation along the direction of gravity is widely accepted as being involved into early stages of gravity perception (the starch-statolith hypothesis; Sack, 1991). Root gravitropism following statoliths displacement is based on auxin redistribution in the root apex, inducing differential growth between the root upward and downward sides. However at the cell scale, the chain of transduction starting from statoliths displacement and leading to auxin redistribution remains poorly documented. Signaling molecules such as calcium, reactive oxygen species, nitric oxide and inositol 1,4,5-triphosphate are serious candidates previously shown to be involved within minutes before modification of the expression of auxin-related genes (Morita, 2010; Sato et al., 2015). Here, we observe and quantify statoliths displacements and locations at various levels of gravity to investigate two hypothesis: (i) Are contacts between statoliths and the endoplasmic reticulum necessary to induce gravitropism? (ii) Are very low displacements of statoliths sufficient to initiate transduction pathways such as the calcium's one? These questionings have led to an experiment called GRAVI-2 which took place aboard the ISS in 2014. During the experiment, lentil roots were grown in the European modular cultivation system for several hours in microgravity and were then submitted to short high gravity stimulus (5 and 15 minutes at 2 g) before the return to Earth for analyses. Ongoing cytological measurements will reveal the effects of statoliths

Uso de atracúrio para o bloqueio da musculatura extrínseca do bulbo ocular em cães submetidos à anestesia inalatória sob ventilação espontânea Blocking of ocular bulb extrinsic musculature by atracurium in inhalant anesthetized dogs under spontaneous breathing

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A.B. Carregaro

2006-12-01

Full Text Available Comparou-se o bloqueio da musculatura extrínseca do bulbo ocular com três doses de atracúrio em cães submetidos à anestesia inalatória sob ventilação espontânea. Em estudo cego, foram utilizados seis cães, pré-medicados com 0,1mg/kg de acepromazina intravenoso (IV, anestesiados com 5mg/kg de propofol, entubados e mantidos sob anestesia inalatória com 1,5% de isofluorano e submetidos a quatro tratamentos: não tratados (controle, tratados com 25µg/kg (G25 de atracúrio IV, com 50µg/kg (G50 de atracúrio IV e com 75µg/kg (G75 de atracúrio IV. Mensuraram-se: pressão parcial de CO2 expirado (ETCO2, freqüência cardíaca (FC, freqüência respiratória (¦, saturação arterial de oxiemoglobina (SatO2 e tempo de centralização do bulbo ocular. Nos grupos tratados com atracúrio, o ETCO2 aumentou aos 5min, e permaneceu aumentado até 10min em G50 e até 20min em G75, sendo este o único tratamento cuja concentração de ETCO2 apresentou-se acima de 50mmHg. Não houve reinalação de CO2 em nenhum grupo. Em G75, observou-se aumento crescente da ¦ até os 40min e considerável bradicardia após 10min; ambos retornaram aos valores basais após esse período. A centralização do bulbo ocular foi crescente de acordo com a dose: G25, 38±13min; G50, 65±16,4 min; G75, 78±27min, mas não houve diferença estatística entre G50 e G75. Conclui-se que G50 apresentou bloqueio satisfatório sem promover intensa e prolongada hipercapnia nos animais.The ocular bulb extrinsic musculature blocking by the administration of three atracurium doses in isoflurane anesthetized dogs under spontaneous breathing was compared. In a blind study, six dogs were premedicated with 0.1mg/kg of acepromazine, anesthetized with 5mg/kg of propofol, intubated and maintained in inhalation anesthesia with 1.5% of isoflurane in 100% of oxygen. Afterwards, they were submitted to four treatments (control, G25:25µg/kg of atracurium IV, G50:50µg/kg IV and G75:75µg/kg IV

Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress

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Tsuru J

2014-11-01

Full Text Available Jusen Tsuru,1 Yoshihiro Tanaka,1 Yoshinobu Ishitobi,1 Yoshihiro Maruyama,1 Ayako Inoue,1 Aimi Kawano,1 Rie Ikeda,1 Tomoko Ando,1 Harumi Oshita,2 Saeko Aizawa,1 Koji Masuda,1 Haruka Higuma,1 Masayuki Kanehisa,1 Taiga Ninomiya,1 Jotaro Akiyoshi1 1Department of Neuropsychiatry, 2Department of Applied Linguistics, Faculty of Medicine, Oita University, Oita, Japan Background: Decreased expression of brain-derived neurotrophic factor (BDNF is implicated in enhanced stress responses. The BDNF Val66Met polymorphism is associated with psychological changes; for example, carriers of the Met allele exhibit increased harm avoidance as well as a higher prevalence of depression and anxiety disorder.Methods: To analyze the effects of BDNF Val66Met on stress responses, we tested 226 university students (88 women and 138 men using a social stress procedure (Trier Social Stress Test [TSST] and an electrical stimulation stress test. Stress indices were derived from repeated measurements of salivary α-amylase, salivary cortisol, heart rate, and psychological testing during the stress tests. All subjects were genotyped for the Val66Met polymorphism (G196A.Results: A significant three-way interaction (time [3 levels] × BDNF [Val/Val, Val/Met, Met/Met]; P<0.05 was demonstrated that revealed different salivary cortisol responses in the TSST but not in electrical stimulation. Met/Met women had stronger cortisol responses than Val/Met and Val/Val individuals in the TSST. Met/Met men exhibited stronger salivary cortisol responses than Val/Met and Val/Val individuals in the TSST.Conclusion: These results indicate that a common, functionally significant polymorphism in BDNF had different effects on hypothalamic–pituitary–adrenocortical axis reactivity but not on sympathetic adrenomedullary reactivity in TSST and electrical stimulation tests. Keywords: stress, brain-derived neurotrophic factor, cortisol, saliva

Production of Enterocins L50A, L50B, and IT, a New Enterocin, by Enterococcus faecium IT62, a Strain Isolated from Italian Ryegrass in Japan▿

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Izquierdo, Esther; Bednarczyk, Audrey; Schaeffer, Christine; Cai, Yimin; Marchioni, Eric; Van Dorsselaer, Alain; Ennahar, Saïd

2008-01-01

Enterococcus faecium IT62, isolated from ryegrass in Japan, was shown to produce three different bacteriocins, two of which had molecular masses and amino acid sequences that corresponded to those of enterocin L50A and enterocin L50B. These peptides existed, however, as chemically modified forms that were either N formylated or N formylated and oxidized at Met24. The third bacteriocin, named enterocin IT, had a molecular mass of 6,390 Da, was made up of 54 amino acids, and did not correspond to any known bacteriocin. However, enterocin IT was identical to the C-terminal part of the 16-amino-acid-longer bacteriocin 32 (T. Inoue, H. Tomita, and Y. Ike, Antimicrob. Agents Chemother., 50:1202-1212, 2006). For the first time, the antimicrobial activity spectra for enterocins L50A and L50B were determined separately and included a wide range of gram-positive bacteria but also a few gram-negative strains that were weakly sensitive. Slight differences in the activities of enterocins L50A and L50B were observed, as gram-positive bacteria showed an overall higher level of sensitivity to L50A than to L50B, as opposed to gram-negative ones. Conversely, enterocin IT showed a very narrow antimicrobial spectrum that was limited to E. faecium strains, one strain of Bacillus subtilis, and one strain of Lactococcus lactis. This study showed that E. faecium IT62, a grass-borne strain, produces bacteriocins with very different activity features and structures that may be found in strains associated with food or those of clinical origin, which demonstrates that a particular enterocin structure may be widespread and not related to the producer's origin. PMID:18391036

Production of enterocins L50A, L50B, and IT, a new enterocin, by Enterococcus faecium IT62, a strain isolated from Italian ryegrass in Japan.

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Izquierdo, Esther; Bednarczyk, Audrey; Schaeffer, Christine; Cai, Yimin; Marchioni, Eric; Van Dorsselaer, Alain; Ennahar, Saïd

2008-06-01

Enterococcus faecium IT62, isolated from ryegrass in Japan, was shown to produce three different bacteriocins, two of which had molecular masses and amino acid sequences that corresponded to those of enterocin L50A and enterocin L50B. These peptides existed, however, as chemically modified forms that were either N formylated or N formylated and oxidized at Met(24). The third bacteriocin, named enterocin IT, had a molecular mass of 6,390 Da, was made up of 54 amino acids, and did not correspond to any known bacteriocin. However, enterocin IT was identical to the C-terminal part of the 16-amino-acid-longer bacteriocin 32 (T. Inoue, H. Tomita, and Y. Ike, Antimicrob. Agents Chemother., 50:1202-1212, 2006). For the first time, the antimicrobial activity spectra for enterocins L50A and L50B were determined separately and included a wide range of gram-positive bacteria but also a few gram-negative strains that were weakly sensitive. Slight differences in the activities of enterocins L50A and L50B were observed, as gram-positive bacteria showed an overall higher level of sensitivity to L50A than to L50B, as opposed to gram-negative ones. Conversely, enterocin IT showed a very narrow antimicrobial spectrum that was limited to E. faecium strains, one strain of Bacillus subtilis, and one strain of Lactococcus lactis. This study showed that E. faecium IT62, a grass-borne strain, produces bacteriocins with very different activity features and structures that may be found in strains associated with food or those of clinical origin, which demonstrates that a particular enterocin structure may be widespread and not related to the producer's origin.

Submucosal tunnel endoscopy: Peroral endoscopic myotomy and peroral endoscopic tumor resection

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Eleftheriadis, Nikolas; Inoue, Haruhiro; Ikeda, Haruo; Onimaru, Manabu; Maselli, Roberta; Santi, Grace

2016-01-01

Peroral endoscopic myotomy (POEM) is an innovative, minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy (LHM), not only for all types of esophageal achalasia [classical (I), vigorous (II), spastic (III), Chicago Classification], but also for advanced sigmoid type achalasia (S1 and S2), failed LHM, or other esophageal motility disorders (diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction (EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection (POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors (submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives. PMID

Osteodystrophy in liver cirrhosis. Its demonstration by 99m Tc methylene diphosphonate bone scintigraphy

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Sezai, Shu-ichi; Ishizawa, Suguru; Yoshino, Katsumasa

1987-10-01

In order to investigate the osteodystrophy in liver cirrhosis, 21 liver cirrhotic patients having no malignancy and normal renal function were examined by 99m Tc Methylene Diphosphonate (MDP) bone scintigraphy. The cirrhotic subjects consisted of 14 males and 7 females. Their age was 31 - 80, average 55.7 years. The causes of their cirrhotic damage were 1 primary biliary cirrhosis, 9 alcoholic, 2 HB viral and 9 cryptogenic. The contents of their illness showed 9 cases in A, 4 in B and 8 in C of Child's classification. Abnormal hot spot(s) on bone in the cirrhotics could be observed very frequently in 99m Tc MDP bone scintigraphy (47.6 %; 10/21 cases). Those spots were seen more frequently in female and advanced stage of cirrhosis. The number of spot(s) increased also in advanced liver cirrhosis. Serum Ca, P and PTH were in normal range. All of three vitamin D/sub 3/ fractions decreased and especially 1,25 (OH)/sub 2/D/sub 3/ was depressed more in scinti-positive cases. Metacarpal bone X-p with an alumimum step wedge as a reference was analyzed by a microdensitometry (MD) method (Inoue T et al) and the pattern of osteopathy (i.e. porosis, malacia and poromalacia) was examined according to Sumi Y et al. MD method was not known yet if there was any definite correlation with bone scintigraphy and the osteopathic pattern belonged to border categories. In conclusion, more attension on hepatic osteodystrophy will be significantly necessary due to the fact that it has been found very frequently in liver cirrhosis. 99m Tc MDP bone scintigraphy is a good means for detection of the hepatic osteodystrophy.

Comparison of clinical features between primary and drug-induced sleep-related eating disorder

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Komada Y

2016-05-01

Full Text Available Yoko Komada,1 Yoshikazu Takaesu,2 Kentaro Matsui,3 Masaki Nakamura,3 Shingo Nishida,3 Meri Kanno,3,† Akira Usui,3 Yuichi Inoue1,3 1Department of Somnology, 2Department of Psychiatry, Tokyo Medical University, 3Japan Somnology Center, Institute of Neuropsychiatry, Tokyo, Japan †Meri Kanno passed away on March 1, 2016 Purpose: The aim of this study was to ascertain the clinical characteristics of drug-induced sleep-related eating disorder (SRED. Patients and methods: We retrospectively reviewed the medical records of 30 patients with primary SRED (without any comorbid sleep disorders and who were not taking any possible causative medications, and ten patients with drug-induced SRED (occurrence of SRED episodes after starting nightly medication of sedative drugs, which completely resolved after dose reduction or discontinuation of the sedatives. Results: All patients with drug-induced SRED took multiple types of sedatives, such as benzodiazepines or benzodiazepine receptor agonists. Clinical features of drug-induced SRED compared with primary SRED were as follows: higher mean age of onset (40 years old in drug-induced SRED vs 26 years old in primary SRED, significantly higher rate of patients who had total amnesia during most of their SRED episodes (75.0% vs 31.8%, significantly lower rate of comorbidity of night eating syndrome (0% vs 63.3%, and significantly lower rate of history of sleepwalking (10.0% vs 46.7%. Increased doses of benzodiazepine receptor agonists may be responsible for drug-induced SRED. Conclusion: The clinical features of drug-induced SRED were different from those of primary SRED, possibly reflecting differences in the underlying mechanisms between these two categories of SREDs. Keywords: nocturnal eating syndrome, night eating, eating disorder, hypnotics, amnesia, sleepwalking, benzodiazepine

[The best of valvular heart disease in 2005].

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de Gevigney, G

2006-01-01

The year 2005 has been rich in publications concerning valvular heart disease. In France, this year has been dominated by the publication of the French Society of Cardiologists' guidelines on the operative and interventional indications for acquired valvular heart disease: discussed and accepted formal indications based on the evidence in the literature. Non-ischaemic mitral insufficiency has been the subject of a major study that showed the high prognostic significance of echographic measuring of the area of the regurgitating orifice; patients with a surface > or =40 mm2 had a worse long-term prognosis and should undergo surgery early. The prognostic significance of BNP in valvular heart disease, such as mitral insufficiency and aortic stenosis, also became apparent. BNP is being used more and more for risk stratification for these conditions. The significance of anti-arrhythmic surgery combined with a mitral procedure has confirmed the harmful effect of atrial fibrillation, before and after the mitral surgery. The first randomised study into the use of statins to slow the progression of aortic stenosis was unfortunately disappointing, despite the various unrandomised studies that had opened a therapeutic pathway for this pathology, for which the prevalence is continually rising due to the ever increasing life expectancy. In mitral stenosis, a randomised study showed the long-term value of mitral commissurotomy in percutaneous mitral valvuloplasty, giving identical long-term results, in terms of mitral area, to those obtained with the classic Inoué balloon. In infectious endocarditis, surveys have confirmed the seriousness of this pathology as well as the slight advances in its prophylaxis. Other studies have confirmed the frequency and the severity of emboli, endocarditis due to Staphylococcus aureus, and the low risk of recurrence for endocarditis with the more and more accepted short course antibiotic treatment for patients undergoing surgery. Of course, this

Molecular gas in the H II-region complex RCW 166: Possible evidence for an early phase of cloud-cloud collision prior to the bubble formation

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Ohama, Akio; Kohno, Mikito; Fujita, Shinji; Tsutsumi, Daichi; Hattori, Yusuke; Torii, Kazufumi; Nishimura, Atsushi; Sano, Hidetoshi; Yamamoto, Hiroaki; Tachihara, Kengo; Fukui, Yasuo

2018-05-01

Young H II regions are an important site for the study of O star formation based on distributions of ionized and molecular gas. We reveal that two molecular clouds at ˜48 km s-1 and ˜53 km s-1 are associated with the H II regions G018.149-00.283 in RCW 166 by using the JCMT CO High-Resolution Survey (COHRS) of the 12CO(J = 3-2) emission. G018.149-00.283 comprises a bright ring at 8 μm and an extended H II region inside the ring. The ˜48 km s-1 cloud delineates the ring, and the ˜53 km s-1 cloud is located within the ring, indicating a complementary distribution between the two molecular components. We propose a hypothesis that high-mass stars within G018.149-00.283 were formed by triggering during cloud-cloud collision at a projected velocity separation of ˜5 km s-1. We argue that G018.149-00.283 is in an early evolutionary stage, ˜0.1 Myr after the collision according to the scheme detailed by Habe and Ohta (1992, PASJ, 44, 203), which will be followed by a bubble formation stage like RCW 120. We also suggest that nearby H II regions N21 and N22 are candidates for bubbles possibly formed by cloud-cloud collision. Inoue and Fukui (2013, ApJ, 774, L31) showed that the interface gas becomes highly turbulent and realizes a high-mass accretion rate of 10-3-10-4 M⊙ yr-1 by magnetohydrodynamical numerical simulations, which offers an explanation of the O-star formation. The fairly high frequency of cloud-cloud collision in RCW 166 is probably due to the high cloud density in this part of the Scutum arm.

Associations among depressive symptoms, childhood abuse, neuroticism, and adult stressful life events in the general adult population

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Ono K

2017-02-01

Full Text Available Kotaro Ono,1 Yoshikazu Takaesu,1 Yukiei Nakai,2 Akiyoshi Shimura,1 Yasuyuki Ono,1 Akiko Murakoshi,1 Yasunori Matsumoto,1 Hajime Tanabe,3 Ichiro Kusumi,2 Takeshi Inoue1 1Department of Psychiatry, Tokyo Medical University, Tokyo, 2Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, 3Department of Clinical Human Sciences, Graduate school of Humanities and Social Sciences, Shizuoka University, Shizuoka, Japan Background: Recent studies have suggested that the interactions among several factors affect the onset, progression, and prognosis of major depressive disorder. This study investigated how childhood abuse, neuroticism, and adult stressful life events interact with one another and affect depressive symptoms in the general adult population. Subjects and methods: A total of 413 participants from the nonclinical general adult population completed the Patient Health Questionnaire-9, the Child Abuse and Trauma Scale, the neuroticism subscale of the shortened Eysenck Personality Questionnaire – Revised, and the Life Experiences Survey, which are self-report scales. Structural equation modeling (Mplus version 7.3 and single and multiple regressions were used to analyze the data. Results: Childhood abuse, neuroticism, and negative evaluation of life events increased the severity of the depressive symptoms directly. Childhood abuse also indirectly increased the negative appraisal of life events and the severity of the depressive symptoms through enhanced neuroticism in the structural equation modeling. Limitations: There was recall bias in this study. The causal relationship was not clear because this study was conducted using a cross-sectional design. Conclusion: This study suggested that neuroticism is the mediating factor for the two effects of childhood abuse on adulthood depressive symptoms and negative evaluation of life events. Childhood abuse directly and indirectly predicted the severity of depressive symptoms

The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents

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Hiroko Sonoyama

2008-10-01

Full Text Available Hiroko Sonoyama1, Kaoru Araki-Sasaki1, Shigeyasu Kazama1, Tsutomu Kawasaki1, Hidenao Ideta1, Atsuko Sunada2, Seishi Asari2, Yoshitsugu Inoue3, Kozaburo Hayashi41Ideta Eye Hospital, Kumamoto, Kumamoto, Japan; 2Department of Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan; 3Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organ, Tottori University, Yonago, Tottori, Japan; 4Immunology and Virology Section Lab, Immunology, NEI, NIH, Bethesda, MD, USAAbstract: Clinical findings and treatment of keratomycosis caused by Beauveria bassiana, an entomopathogenic filamentous fungus, are described for an 80-year-old woman, who was referred to the hospital for ocular pain and redness on the 9th day after an ocular injury caused by the frame of her glasses. She had a long history of recurrent diabetic iritis and continuously used topical antibiotics and corticosteroids. At her first visit, a slit-lamp examination indicated a corneal ulcer confined within the superficial stromal layer, along with a slight infiltration and edema. Only a very few inflammatory cells were seen in the anterior chamber. Direct microscopic examination of corneal scrapings revealed septate fungal hyphae with zig-zag rachis and budding that was subsequently identified as B. bassiana by slide culture. Topical voriconazole with miconazole, pimaricin and oral itraconazole were effective and the lesion disappeared leaving only a mild scar at 2 months. The sensitivity of B. bassiana to various antimycotic agents was confirmed by broth microdilution, agar dilution with the Clinical Laboratory Standard Institute standard, and a disk method using topically applied concentrations. B. bassiana, which exhibits a characteristic appearance in smears and causes superficial keratomycosis, is sensitive to voriconazole with miconazole, pimaricin, and itraconazole.Keywords: Beauveria bassiana, keratomycosis, filamentous

Increased expression of IRE1α and stress-related signal transduction proteins in ischemia-reperfusion injured retina

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Natsuyo Hata

2008-08-01

Full Text Available Natsuyo Hata1, Toshiyuki Oshitari1,2, Akiko Yokoyama1,3, Yoshinori Mitamura1, Shuichi Yamamoto11Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan; 2Department of Ophthalmology, Kimitsu Central Hospital, Kisarazu City, Chiba, Japan; 3Department of Ophthalmology, Inoue Memorial Hospital, Chuo-ku, Chiba, JapanAbstract: The purpose of this study was to determine whether the expression of ER stress-related factors IRE1α, apoptosis signal-regulating kinase 1 (ASK1, SAPK/ERK kinase 1 (SEK1 and c-Jun N-terminal kinase (JNK is associated with the damaged retinal neurons induced by ischemia-reperfusion injury. After 60 minutes of ischemia, the rat retinas were reperfused, and retinas were isolated and fixed after 6, 9, 12, 18, and 24 hours, and 2, 5, and 9 days of reperfusion. Cryosections were immunostained with Fluoro-Jade B, a degenerating neuron marker to label degenerating neurons. Semi-quantitative analysis of the expression of IRE1α, ASK1, SEK1, and JNK were performed in both control and ischemic retinas. In ischemic retinas, the intensities of IRE1α immunoreactivity in the ganglion cell layer (GCL were significantly higher than in the control retinas. In ischemic retinas, the numbers of SEK1-, ASK1-, and JNK-positive cells were significantly increased in the GCL compared to those in the control retinas. In addition, the cells that were positive for SEK1-, ASK1-, and JNK were also positive for Fluoro-Jade B-positive cells. These results indicate that the increased expression of ER stress-related factors was, in part, associated with the retinal neuronal abnormalities after ischemia-reperfusion injury in rat retinas.Keywords: endoplasmic reticulum, IRE1α, apoptosis signal-regulating kinase 1, SAPK/ERK kinase 1, c-Jun N-terminal kinase, Fluoro-Jade B, ischemia-reperfusion injury

RESULTADOS DE LA VALVULOPLASTIA MITRAL PERCUTÁNEA. EXPERIENCIA EN EL INSTITUTO DE CARDIOLOGÍA Y CIRUGÍA CARDIOVASCULAR DE CUBA (1998-2004 / Results of percutaneous mitral valvuloplasty. Experiences at the Cardiology and Cardiovascular Surgery Institute in Cuba (1998-2004

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Raymid García Fernández

2010-03-01

Full Text Available Antecedents and Objectives: The percutaneous mitral valvuloplasty is the procedure of choice in patients with mitral stenosis and an adequate valvular anatomy. The cases treated in Cuba were few until 1998, and the first ones were carried out by foreign medical professionals. This article aims at showing the results of the development of this technique in Cuba. Method: A total of 110 consecutive percutaneous mitral valvuloplasties were carried out in 107 patients (three of them were repeated due to restenosis at the Cuban Cardiology and Cardiovascular Surgery Institute, between June 17th 1998 and June 30th 2004 (106 using the Inoue method and 4 by Multi-track. The average evolution time was 24.6 months (72 maximum and 1,93 minimum. Results: Before the procedure, 94.54 percent of the patients were within the functional classification III and IV of the NYHA; after the procedure 96,36 percent were within functional classification I and II. Using the Wilkins score ≤ 8, average areas of 2,18 cm2 were obtained; and between 9 and 12, areas of 1,81 cm2. The initial success of the procedure was 96,36 percent, and without complications 92,72 percent. Mortality was 0,9 percent, survival 100 percent, and 91,74 percent of the patients were free from complications. As an adverse event in the follow-up it was determined a mitral reestenosis in 5 patients (4,54 %. The average stay in hospital was of 1,36 days. The savings concerning hospitalization was of $ 4136775.39. Conclusions: Percutaneous mitral valvuloplasty is a safe and effective method in patients with mitral stenosis; its results remain in the sort, medium or long run.

Synthetic ciguatoxins selectively activate Nav1.8-derived chimeric sodium channels expressed in HEK293 cells.

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Yamaoka, Kaoru; Inoue, Masayuki; Miyazaki, Keisuke; Hirama, Masahiro; Kondo, Chie; Kinoshita, Eiji; Miyoshi, Hiroshi; Seyama, Issei

2009-03-20

The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M. (2004) Br. J. Pharmacol. 142, 879-889). In this study, we further explored the effects of CTX3C on the TTX-resistant sodium channel Na(v)1.8. TTX-resistant channels have been shown to be involved in transducing pain and related sensations (Akopian, A. N., Sivilotti, L., and Wood, J. N. (1996) Nature 379, 257-262). Thus, we hypothesized that ciguatoxin-induced activation of the Na(v)1.8 current would account for the neurological symptoms of ciguatera poisoning. We found that 0.1 mum CTX3C preferentially affected the activation process of the Na(v)1.8 channel compared with those of the Na(v)1.2 and Na(v)1.4 channels. Importantly, without stimulation, 0.1 mum CTX3C induced a large leakage current (I (L)). The conductance of the I (L) calculated relative to the maximum conductance (G (max)) was 10 times larger than that of Na(v)1.2 or Na(v)1.4. To determine the molecular domain of Na(v)1.8 responsible for conferring higher sensitivity to CTX3C, we made two chimeric constructs from Na(v)1.4 and Na(v)1.8. Chimeras containing the N-terminal half of Na(v)1.8 exhibited a large response similar to wild-type Na(v)1.8, indicating that the region conferring high sensitivity to ciguatoxin action is located in the D1 or D2 domains.

Nepotřebuju podpatky: s Kateřinou Pioreckou o historických paralelách, o psaní i o tom, jaké to je, stát se literární postavou

Czech Academy of Sciences Publication Activity Database

Piorecká, Kateřina; Martínková-Racková, S.

2017-01-01

Roč. 28, č. 15 (2017), s. 4-5 ISSN 0862-657X Institutional support: RVO:68378068 Keywords : literary history - historical memory - writing technology * historical memory * writing technology Subject RIV: AJ - Letters, Mass-media, Audiovision

Eleven years of experience with bisphosphonate plus alfacalcidol treatment in a man with osteogenesis imperfecta type I

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Iwamoto J

2012-12-01

Full Text Available Jun Iwamoto,1 Yoshihiro Sato,2 Mitsuyoshi Uzawa,3 Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, 2Department of Neurology, Mitate Hospital, Fukuoka, 3Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, JapanAbstract: We report the 11-year follow-up of a man with osteogenesis imperfecta type I who was treated with bisphosphonates and alfacalcidol. A 36-year-old Japanese man with osteogenesis imperfecta type I who had frequently experienced painful fragility fractures consulted our clinic because of chronic back pain. The patient had multiple morphometric vertebral fractures and a low bone mineral density (BMD at the lumbar spine. The patient was treated with cyclical etidronate 200 mg, for 2 weeks every 3 months, plus alfacalcidol 1 µg daily, for 2 years; and alendronate 5 mg daily or 35 mg weekly, plus alfacalcidol 1 µg daily for 9 years. After 11 years of treatment, BMD at the lumbar spine increased by 6.4%, following a 20.3% reduction in serum alkaline phosphatase. Serum calcium, phosphorus, and intact parathyroid hormone levels remained within the normal ranges. Three clinical fractures occurred at two ribs and the metacarpus, and two morphometric vertebral fractures occurred at the thoracic spine during the 11-year treatment period, but the patient experienced no adverse effects. Thus, the present case report shows the long-term outcome and safety of bisphosphonate plus alfacalcidol treatment in a man with osteogenesis imperfecta type I.Keywords: etidronate, alendronate, fragility fracture, bone mineral density, osteogenesis imperfecta

Acoustic wave simulation using an overset grid for the global monitoring system

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Kushida, N.; Le Bras, R.

2017-12-01

The International Monitoring System of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) has been monitoring hydro-acoustic and infrasound waves over the globe. Because of the complex natures of the oceans and the atmosphere, computer simulation can play an important role in understanding the observed signals. In this regard, methods which depend on partial differential equations and require minimum modelling, are preferable. So far, to our best knowledge, acoustic wave propagation simulations based on partial differential equations on such a large scale have not been performed (pp 147 - 161 of ref [1], [2]). The main difficulties in building such simulation codes are: (1) considering the inhomogeneity of medium including background flows, (2) high aspect ratio of computational domain, (3) stability during long time integration. To overcome these difficulties, we employ a two-dimensional finite different (FDM) scheme on spherical coordinates with the Yin-Yang overset grid[3] solving the governing equation of acoustic waves introduces by Ostashev et. al.[4]. The comparison with real recording examples in hydro-acoustic will be presented at the conference. [1] Paul C. Etter: Underwater Acoustic Modeling and Simulation, Fourth Edition, CRC Press, 2013. [2] LIAN WANG et. al.: REVIEW OF UNDERWATER ACOUSTIC PROPAGATION MODELS, NPL Report AC 12, 2014. [3] A. Kageyama and T. Sato: "Yin-Yang grid": An overset grid in spherical geometry, Geochem. Geophys. Geosyst., 5, Q09005, 2004. [4] Vladimir E. Ostashev et. al: Equations for finite-difference, time-domain simulation of sound propagation in moving inhomogeneous media and numerical implementation, Acoustical Society of America. DOI: 10.1121/1.1841531, 2005.

Evaluation of the histological and mechanical features of tendon healing in a rabbit model with the use of second-harmonic-generation imaging and tensile testing.

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Hase, E; Sato, K; Yonekura, D; Minamikawa, T; Takahashi, M; Yasui, T

2016-11-01

This study aimed to evaluate the histological and mechanical features of tendon healing in a rabbit model with second-harmonic-generation (SHG) imaging and tensile testing. A total of eight male Japanese white rabbits were used for this study. The flexor digitorum tendons in their right leg were sharply transected, and then were repaired by intratendinous stitching. At four weeks post-operatively, the rabbits were killed and the flexor digitorum tendons in both right and left legs were excised and used as specimens for tendon healing (n = 8) and control (n = 8), respectively. Each specimen was examined by SHG imaging, followed by tensile testing, and the results of the two testing modalities were assessed for correlation. While the SHG light intensity of the healing tendon samples was significantly lower than that of the uninjured tendon samples, 2D Fourier transform SHG images showed a clear difference in collagen fibre structure between the uninjured and the healing samples, and among the healing samples. The mean intensity of the SHG image showed a moderate correlation (R 2 = 0.37) with Young's modulus obtained from the tensile testing. Our results indicate that SHG microscopy may be a potential indicator of tendon healing.Cite this article: E. Hase, K. Sato, D. Yonekura, T. Minamikawa, M. Takahashi, T. Yasui. Evaluation of the histological and mechanical features of tendon healing in a rabbit model with the use of second-harmonic-generation imaging and tensile testing. Bone Joint Res 2016;5:577-585. DOI: 10.1302/2046-3758.511.BJR-2016-0162.R1. © 2016 Yasui et al.

Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy.

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Rancourt, Ann; Dufresne, Sébastien S; St-Pierre, Guillaume; Lévesque, Julie-Christine; Nakamura, Haruka; Kikuchi, Yodai; Satoh, Masahiko S; Frenette, Jérôme; Sato, Sachiko

2018-06-12

The muscle membrane, sarcolemma, must be firmly attached to the basal lamina. The failure of proper attachment results in muscle injury, which is the underlying cause of Duchenne muscular dystrophy (DMD), in which mutations in the dystrophin gene disrupts the firm adhesion. In patients with DMD, even moderate contraction causes damage, leading to progressive muscle degeneration. The damaged muscles are repaired through myogenesis. Consequently, myogenesis is highly active in patients with DMD, and the repeated activation of myogenesis leads to the exhaustion of the myogenic stem cells. Therefore, approaches to reducing the risk of the exhaustion are to develop a treatment that strengthens the interaction between the sarcolemma and the basal lamina and increases the efficiency of the myogenesis. Galectin-3 is an oligosaccharide-binding protein and is known to be involved in cell-cell interactions and cell-matrix interactions. Galectin-3 is expressed in myoblasts and skeletal muscle, although its function in muscle remains elusive. In this study, we found evidence that galectin-3 and the monosaccharide N-acetylglucosamine, which increases the synthesis of binding partners (oligosaccharides) of galectin-3, promote myogenesis in vitro. Moreover, in the mdx mouse model of DMD, treatment with N-acetylglucosamine increased muscle-force production. The results suggest that treatment with N-acetylglucosamine might mitigate the burden of DMD.-Rancourt, A., Dufresne, S. S., St-Pierre, G., Lévesque, J.-C., Nakamura, H., Kikuchi, Y., Satoh, M. S., Frenette, J., Sato, S. Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy.

Apparent suppression of MMP-9 activity by GD1a as determined by gelatin zymography.

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Hu, Dan; Tan, Xuan; Sato, Toshinori; Yamagata, Sadako; Yamagata, Tatsuya

2006-10-13

Gelatin zymography is widely used to detect and evaluate matrix metalloproteinase-9 (MMP-9) activity. MMP-9 transcription was previously shown to be negatively regulated by ganglioside GD1a [D. Hu, Z. Man, T. Xuan, P. Wang, T. Takaku, S. Hyuga, X.S. Yao, T. Sato, S. Yamagata, T. Yamagata, Ganglioside GD1a regulation of matrix metalloproteinase-9 (MMP-9) expression in mouse FBJ cell Lines: GD1a suppression of MMP-9 expression stimulated by PI3K-Akt and p38 though not by the Erk signaling pathway, 2006, submitted for publication.]. Zymography of MMP-9 of FBJ-M5 cells preincubated with GD1a indicated a greater decrease in activity than expected from mRNA suppression. Incubation of conditioned medium containing MMP-9 with GD1a caused MMP-9 activity to decrease. Examination was thus made to confirm that MMP-9 activity is actually suppressed and/or MMP-9 protein undergoes degradation by GD1a. GD1a was found to have no effect on MMP-9 activity and Western blots indicated GD1a not to diminish MMP-9 during electrophoresis under reducing conditions. GD1a appeared to mediate the binding of a portion of MMP-9 with certain molecules, with consequently greater molecular mass on the gel, to cause decrease in the activity of MMP-9 at the site where it would normally appear. Caution should be used in doing gelatin zymography since molecules other than GD1a may similarly work, causing decrease in MMP-9 activity in zymography.

SIMULATIONS OF WIDE-FIELD WEAK-LENSING SURVEYS. II. COVARIANCE MATRIX OF REAL-SPACE CORRELATION FUNCTIONS

International Nuclear Information System (INIS)

Sato, Masanori; Matsubara, Takahiko; Takada, Masahiro; Hamana, Takashi

2011-01-01

Using 1000 ray-tracing simulations for a Λ-dominated cold dark model in Sato et al., we study the covariance matrix of cosmic shear correlation functions, which is the standard statistics used in previous measurements. The shear correlation function of a particular separation angle is affected by Fourier modes over a wide range of multipoles, even beyond a survey area, which complicates the analysis of the covariance matrix. To overcome such obstacles we first construct Gaussian shear simulations from the 1000 realizations and then use the Gaussian simulations to disentangle the Gaussian covariance contribution to the covariance matrix we measured from the original simulations. We found that an analytical formula of Gaussian covariance overestimates the covariance amplitudes due to an effect of the finite survey area. Furthermore, the clean separation of the Gaussian covariance allows us to examine the non-Gaussian covariance contributions as a function of separation angles and source redshifts. For upcoming surveys with typical source redshifts of z s = 0.6 and 1.0, the non-Gaussian contribution to the diagonal covariance components at 1 arcmin scales is greater than the Gaussian contribution by a factor of 20 and 10, respectively. Predictions based on the halo model qualitatively well reproduce the simulation results, however show a sizable disagreement in the covariance amplitudes. By combining these simulation results we develop a fitting formula to the covariance matrix for a survey with arbitrary area coverage, taking into account effects of the finiteness of survey area on the Gaussian covariance.

Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects

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Sato A

2012-04-01

Full Text Available Akinori SatoDepartment of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, JapanAbstract: Histone acetylation and deacetylation play important roles in the regulation of gene transcription and in the modulation of chromatin structure. The levels of histone acetylation are determined by the activities of histone acetyltransferases and histone deacetylases (HDACs. HDACs are associated with a number of oncogenes and tumor suppressor genes and can be aberrantly expressed and/or inappropriately activated in cancer cells. HDAC inhibitors have therefore recently emerged as a novel treatment modality against malignancies. They regulate gene expression by enhancing the acetylation of not only histones but also nonhistone proteins, including transcription factors, transcription regulators, signal transduction mediators, and DNA repair enzymes, and they inhibit cancer growth. Vorinostat (suberoylanilide hydroxamic acid is one of the most potent HDAC inhibitors, and was approved in Japan in 2011 for the treatment of cutaneous T-cell lymphoma. Numerous clinical trials have shown it to be effective against cutaneous T-cell lymphoma but less so against other types of cancer. Because vorinostat can overcome resistance to or enhance the efficacy of other anticancer agents, such as 5-fluorouracil, carboplatin, paclitaxel, bortezomib, and tamoxifen, combination therapies using vorinostat and these agents have been investigated. This review introduces the background and mechanism of action of vorinostat and describes the results of clinical trials using vorinostat, both as a single agent and in combination with other anticancer agents, against cutaneous T-cell lymphoma and other malignancies.Keywords: vorinostat, T-cell lymphoma, cancer, novel treatment

A Computational Model for the Automatic Diagnosis of Attention Deficit Hyperactivity Disorder Based on Functional Brain Volume

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Lirong Tan

2017-09-01

Full Text Available In this paper, we investigated the problem of computer-aided diagnosis of Attention Deficit Hyperactivity Disorder (ADHD using machine learning techniques. With the ADHD-200 dataset, we developed a Support Vector Machine (SVM model to classify ADHD patients from typically developing controls (TDCs, using the regional brain volumes as predictors. Conventionally, the volume of a brain region was considered to be an anatomical feature and quantified using structural magnetic resonance images. One major contribution of the present study was that we had initially proposed to measure the regional brain volumes using fMRI images. Brain volumes measured from fMRI images were denoted as functional volumes, which quantified the volumes of brain regions that were actually functioning during fMRI imaging. We compared the predictive power of functional volumes with that of regional brain volumes measured from anatomical images, which were denoted as anatomical volumes. The former demonstrated higher discriminative power than the latter for the classification of ADHD patients vs. TDCs. Combined with our two-step feature selection approach which integrated prior knowledge with the recursive feature elimination (RFE algorithm, our SVM classification model combining functional volumes and demographic characteristics achieved a balanced accuracy of 67.7%, which was 16.1% higher than that of a relevant model published previously in the work of Sato et al. Furthermore, our classifier highlighted 10 brain regions that were most discriminative in distinguishing between ADHD patients and TDCs. These 10 regions were mainly located in occipital lobe, cerebellum posterior lobe, parietal lobe, frontal lobe, and temporal lobe. Our present study using functional images will likely provide new perspectives about the brain regions affected by ADHD.

Comparative Plasmodium gene overexpression reveals distinct perturbation of sporozoite transmission by profilin.

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Sato, Yuko; Hliscs, Marion; Dunst, Josefine; Goosmann, Christian; Brinkmann, Volker; Montagna, Georgina N; Matuschewski, Kai

2016-07-15

Plasmodium relies on actin-based motility to migrate from the site of infection and invade target cells. Using a substrate-dependent gliding locomotion, sporozoites are able to move at fast speed (1-3 μm/s). This motility relies on a minimal set of actin regulatory proteins and occurs in the absence of detectable filamentous actin (F-actin). Here we report an overexpression strategy to investigate whether perturbations of F-actin steady-state levels affect gliding locomotion and host invasion. We selected two vital Plasmodium berghei G-actin-binding proteins, C-CAP and profilin, in combination with three stage-specific promoters and mapped the phenotypes afforded by overexpression in all three extracellular motile stages. We show that in merozoites and ookinetes, additional expression does not impair life cycle progression. In marked contrast, overexpression of C-CAP and profilin in sporozoites impairs circular gliding motility and salivary gland invasion. The propensity for productive motility correlates with actin accumulation at the parasite tip, as revealed by combinations of an actin-stabilizing drug and transgenic parasites. Strong expression of profilin, but not C-CAP, resulted in complete life cycle arrest. Comparative overexpression is an alternative experimental genetic strategy to study essential genes and reveals effects of regulatory imbalances that are not uncovered from deletion-mutant phenotyping. © 2016 Sato et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Poisson traces, D-modules, and symplectic resolutions.

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Etingof, Pavel; Schedler, Travis

2018-01-01

We survey the theory of Poisson traces (or zeroth Poisson homology) developed by the authors in a series of recent papers. The goal is to understand this subtle invariant of (singular) Poisson varieties, conditions for it to be finite-dimensional, its relationship to the geometry and topology of symplectic resolutions, and its applications to quantizations. The main technique is the study of a canonical D-module on the variety. In the case the variety has finitely many symplectic leaves (such as for symplectic singularities and Hamiltonian reductions of symplectic vector spaces by reductive groups), the D-module is holonomic, and hence, the space of Poisson traces is finite-dimensional. As an application, there are finitely many irreducible finite-dimensional representations of every quantization of the variety. Conjecturally, the D-module is the pushforward of the canonical D-module under every symplectic resolution of singularities, which implies that the space of Poisson traces is dual to the top cohomology of the resolution. We explain many examples where the conjecture is proved, such as symmetric powers of du Val singularities and symplectic surfaces and Slodowy slices in the nilpotent cone of a semisimple Lie algebra. We compute the D-module in the case of surfaces with isolated singularities and show it is not always semisimple. We also explain generalizations to arbitrary Lie algebras of vector fields, connections to the Bernstein-Sato polynomial, relations to two-variable special polynomials such as Kostka polynomials and Tutte polynomials, and a conjectural relationship with deformations of symplectic resolutions. In the appendix we give a brief recollection of the theory of D-modules on singular varieties that we require.

Oral administration of French maritime pine bark extract (Flavangenol® improves clinical symptoms in photoaged facial skin

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Furumura M

2012-07-01

Full Text Available Minao Furumura,1,2 Noriko Sato,1 Nobutaka Kusaba,3 Kinya Takagaki,3 Juichiro Nakayama11Department of Dermatology, Fukuoka University School of Medicine, Fukuoka, 2Department of Dermatology, Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology, Fukuoka, 3Toyo Shinyaku Co Ltd, Tosu City, Saga, JapanBackground: French maritime pine bark extract (PBE has gained popularity as a dietary supplement in the treatment of various diseases due to its polyphenol-rich ingredients. Oligometric proanthocyanidins (OPCs, a class of bioflavonoid complexes, are enriched in French maritime PBE and have antioxidant and anti-inflammatory activity. Previous studies have suggested that French maritime PBE helps reduce ultraviolet radiation damage to the skin and may protect human facial skin from symptoms of photoaging. To evaluate the clinical efficacy of French maritime PBE in the improvement of photodamaged facial skin, we conducted a randomized trial of oral supplementation with PBE.Methods: One hundred and twelve women with mild to moderate photoaging of the skin were randomized to either a 12-week open trial regimen of 100 mg PBE supplementation once daily or to a parallel-group trial regimen of 40 mg PBE supplementation once daily.Results: A significant decrease in clinical grading of skin photoaging scores was observed in both time courses of 100 mg daily and 40 mg daily PBE supplementation regimens. A significant reduction in the pigmentation of age spots was also demonstrated utilizing skin color measurements.Conclusion: Clinically significant improvement in photodamaged skin could be achieved with PBE. Our findings confirm the efficacy and safety of PBE.Keywords: polyphenols, pine bark extract, skin photoaging, antioxidants, antiaging

Poisson traces, D-modules, and symplectic resolutions

Science.gov (United States)

Etingof, Pavel; Schedler, Travis

2018-03-01

We survey the theory of Poisson traces (or zeroth Poisson homology) developed by the authors in a series of recent papers. The goal is to understand this subtle invariant of (singular) Poisson varieties, conditions for it to be finite-dimensional, its relationship to the geometry and topology of symplectic resolutions, and its applications to quantizations. The main technique is the study of a canonical D-module on the variety. In the case the variety has finitely many symplectic leaves (such as for symplectic singularities and Hamiltonian reductions of symplectic vector spaces by reductive groups), the D-module is holonomic, and hence, the space of Poisson traces is finite-dimensional. As an application, there are finitely many irreducible finite-dimensional representations of every quantization of the variety. Conjecturally, the D-module is the pushforward of the canonical D-module under every symplectic resolution of singularities, which implies that the space of Poisson traces is dual to the top cohomology of the resolution. We explain many examples where the conjecture is proved, such as symmetric powers of du Val singularities and symplectic surfaces and Slodowy slices in the nilpotent cone of a semisimple Lie algebra. We compute the D-module in the case of surfaces with isolated singularities and show it is not always semisimple. We also explain generalizations to arbitrary Lie algebras of vector fields, connections to the Bernstein-Sato polynomial, relations to two-variable special polynomials such as Kostka polynomials and Tutte polynomials, and a conjectural relationship with deformations of symplectic resolutions. In the appendix we give a brief recollection of the theory of D-modules on singular varieties that we require.

Practice makes pretty good: assessment of primary literature reading abilities across multiple large-enrollment biology laboratory courses.

Science.gov (United States)

Sato, Brian K; Kadandale, Pavan; He, Wenliang; Murata, Paige M N; Latif, Yama; Warschauer, Mark

2014-01-01

Primary literature is essential for scientific communication and is commonly utilized in undergraduate biology education. Despite this, there is often little time spent training our students how to critically analyze a paper. To address this, we introduced a primary literature module in multiple upper-division laboratory courses. In this module, instructors conduct classroom discussions that dissect a paper as researchers do. While previous work has identified classroom interventions that improve primary literature comprehension within a single course, our goal was to determine whether including a scientific paper module in our classes could produce long-term benefits. On the basis of performance in an assessment exam, we found that our module resulted in longitudinal gains, including increased comprehension and critical-thinking abilities in subsequent lab courses. These learning gains were specific to courses utilizing our module, as no longitudinal gains were seen in students who had taken other upper-division labs that lacked extensive primary literature discussion. In addition, we assessed whether performance on our assessment correlated with a variety of factors, including grade point average, course performance, research background, and self-reported confidence in understanding of the article. Furthermore, all of the study conclusions are independent of biology disciplines, as we observe similar trends within each course. © 2014 B. K. Sato et al. CBE—Life Sciences Education © 2014 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Seasonal variation and sources of atmospheric gravity waves in the Antarctic

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Kaoru Sato

2010-12-01

Full Text Available In the last recent ten years, our knowledge of gravity waves in the Antarctic has been significantly improved through numerous studies using balloon and satellite observations and high-resolution model simulations. In this report, we introduce results from two studies which were performed as a part of the NIPR project "Integrated analysis of the material circulation in the Antarctic atmosphere-cryosphere-ocean" (2004-2009, i.e., Yoshiki et al. (2004 and Sato and Yoshiki (2008. These two studies focused on the seasonal variation and sources of the gravity waves in the Antarctic, because horizontal wavelengths and phase velocities depend largely on the wave sources. The former study used original high-resolution data from operational radiosonde observations at Syowa Station. In the lowermost stratosphere, gravity waves do not exhibit characteristic seasonal variation; instead, the wave energy is intensified when lower latitude air intrudes into the area near Syowa Station in the upper troposphere. This intrusion is associated with blocking events or developed synoptic-scale waves. In the lower and middle stratosphere, the gravity wave energy is maximized in spring and particularly intensified when the axis of the polar night jet approaches Syowa Station. The latter study is based on intensive radiosonde observation campaigns that were performed in 2002 at Syowa Station as an activity of JARE-43. Gravity wave propagation was statistically examined using two dimensional (i.e., vertical wavenumber versus frequency spectra in each season. It was shown that the gravity waves are radiated upward and downward from an unbalanced region of the polar night jet. This feature is consistent with the gravity-wave resolving GCM simulation.

High-dose V+ implantation in ZnO thin film structures

International Nuclear Information System (INIS)

Vyatkin, A.F.; Zinenko, V.I.; Agaphonov, Yu.A.; Pustovit, A.N.; Roshchupkin, D.V.; Reuss, F.; Kirchner, C.; Kling, R.; Waag, A.

2005-01-01

In the last two decades, diluted magnetic semiconductors have attracted great attention as promising materials for spintronics applications. [K. Sato, H. Katyama-Yoshida, Jpn. J. Phys., Part 2 39 (2000) L555] theoretically predicted that ZnO doped with V, Cr, Fe, Co, and Ni can be ferromagnetic. This has been recently confirmed experimentally for vanadium doped ZnO films which were grown on sapphire substrates, using laser deposition technique [H. Saeki, H.N. Tabata, T. Kawai, Solid State Commun. 120 (2001) 439]. In the present work, high-dose vanadium implantation was used to produce Zn 1-x V x O (x ∼ 0.10) thin film structures (250 nm thick) that had been epitaxially grown on sapphire substrates. Implantation with the dose 2 x 10 16 cm -2 was performed to reach a maximum vanadium concentration of 10 at%. To avoid ZnO film amorphization due to radiation damage accumulation [S.O. Kucheyev, J.S. Williams, C. Jagadish, J. Zou, C. Evans, A.J. Nelson, A.V. Hamza, Phys. Rev. B 67 (2003) 094115], all implants were done at elevated temperatures 300 and 400 deg. C and ion current density 10 μA/cm 2 . X-ray diffraction, SIMS and photoluminescence techniques were exploited to study the implanted samples. No luminescence was observed in the implanted samples after implantation procedures. However, annealing at 800 deg. C for 30 min gave rise to ZnO crystal structure improvement. This implies that healing of implantation induced defects is possible even after heavy-ion bombardment. As a result, the photoluminescence peak at 3.359 eV related to the donorbound exiton was detected

The spatial structure of magnetospheric plasma disturbance estimated by using magnetic data obtained by SWARM satellites.

Science.gov (United States)

Yokoyama, Y.; Iyemori, T.; Aoyama, T.

2017-12-01

Field-aligned currents with various spatial scales flow into and out from high-latitude ionosphere. The magnetic fluctuations observed by LEO satellites along their orbits having period longer than a few seconds can be regarded as the manifestations of spatial structure of field aligned currents.This has been confirmed by using the initial orbital characteristics of 3 SWARM-satellites. From spectral analysis, we evaluated the spectral indices of these magnetic fluctuations and investigated their dependence on regions, such as magnetic latitude and MLT and so on. We found that the spectral indices take quite different values between the regions lower than the equatorward boundary of the auroral oval (around 63 degrees' in magnetic latitude) and the regions higher than that. On the other hands, we could not find the clear MLT dependence. In general, the FACs are believed to be generated in the magnetiospheric plasma sheet and boundary layer, and they flow along the field lines conserving their currents.The theory of FAC generation [e.g., Hasegawa and Sato ,1978] indicates that the FACs are strongly connected with magnetospheric plasma disturbances. Although the spectral indices above are these of spatial structures of the FACs over the ionosphere, by using the theoretical equation of FAC generation, we evaluate the spectral indices of magnetospheric plasma disturbance in FAC's generation regions. Furthermore, by projecting the area of fluctuations on the equatorial plane of magnetosphere (i.e. plasma sheet), we can estimate the spatial structure of magnetospheric plasma disturbance. In this presentation, we focus on the characteristics of disturbance in midnight region and discuss the relations to the substorm.

PREFACE Preface

Science.gov (United States)

Takahashi, Migaku; Saito, Hitoshi; Yoshimura, Satoru; Takanashi, Koki; Sahashi, Masashi; Tsunoda, Masakiyo

2011-01-01

23 countries, with about 40 percent of participants attending from overseas (see figure). The program involved 4 plenary talks (45 minutes each), 37 invited talks (30 minutes), 85 contributed talks (15 minutes), and 352 posters. Pie chart Organizing Committee of ISAMMA 2010 M TakahashiTohoku Univ., Japan, Chairman K TakanashiTohoku Univ., Japan, Chair of the Program Committee H SaitoAkita Univ., Japan, Chair of the Publication Committee M SahashiTohoku Univ., Japan, Chair of the Treasury Committee M TsunodaTohoku Univ., Japan, General Secretary H AkinagaAIST, Japan H FukunagaNagasaki Univ., Japan K HonoNIMS, Japan S IshioAkita Univ., Japan S IwataNagoya Univ., Japan K NakagawaNihon Univ., Japan S NakagawaTokyo Inst. of Tech., Japan T OnoKyoto Univ., Japan Y SuzukiOsaka Univ., Japan M TanakaEhime Univ., Japan T Tanaka Univ. of Tokyo, Japan Program Committee of ISAMMA 2010 K TakanashiTohoku Univ., Japan, ChairS MizukamiTohoku Univ., Japan M MizuguchiTohoku Univ., Japan, Vice-chairH NaganumaTohoku Univ., Japan M DoiTohoku Univ., JapanS NakagawaTokyo Inst. of Tech., Japan A FujitaTohoku Univ., JapanK NakamuraTohoku Univ., Japan K IshiyamaTohoku Univ., JapanK OnoKEK, Japan T KatoNagoya Univ., JapanT OnoKyoto Univ., Japan T KawagoeOsaka Pref. Univ.of Edu., JapanF SatoTohoku Univ., Japan O KitakamiTohoku Univ., JapanM ShiraiTohoku Univ., Japan Y KitamotoTokyo Inst. of Tech., JapanS SugimotoTohoku Univ., Japan F MatsukuraTohoku Univ., JapanM YamaguchiTohoku Univ., Japan C MitsumataHitachi Metals, Japan Publication Committee of ISAMMA 2010 H SaitoAkita Univ., Japan, ChairS MitaniNIMS, Japan S YoshimuraAkita Univ., Japan, Vice-chairH MuraokaTohoku, Japan Y AndoTohoku Univ., JapanM NakanoNagasaki Univ., Japan J AriakeAIT, JapanR NakataniOsaka Univ., Japan H AsanoNagoya Univ., JapanK O'GradyUniv. of York, UK M FutamotoChuo Univ., JapanA SakumaTohoku Univ., Japan J HayakawaHitachi, ARL, JapanT SatoKeio Univ., Japan T HondaKyushu Inst. of Tech., JapanT SatoShinshu Univ., Japan M

Study of dispersive and nonlinear effects of coastal wave dynamics with a fully nonlinear potential flow model

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Benoit, Michel; Yates, Marissa L.; Raoult, Cécile

2017-04-01

Efficient and accurate numerical models simulating wave propagation are required for a variety of engineering projects including the evaluation of coastal risks, the design of protective coastal structures, and the estimation of the potential for marine renewable energy devices. Nonlinear and dispersive effects are particularly significant in the coastal zone where waves interact with the bottom, the shoreline, and coastal structures. The main challenge in developing a numerical models is finding a compromise between computational efficiency and the required accuracy of the simulated wave field. Here, a potential approach is selected and the (fully nonlinear) water wave problem is formulated using the Euler-Zakharov equations (Zakharov, 1968) describing the temporal evolution of the free surface elevation and velocity potential. The proposed model (Yates and Benoit, 2015) uses a spectral approach in the vertical (i.e. the vertical variation of the potential is approximated by a linear combination of the first NT+1 Chebyshev polynomials, following the work of Tian and Sato (2008)). The Zakharov equations are integrated in time using a fourth-order Runge-Kutta scheme with a constant time step. At each sub-timestep, the Laplace Boundary Value Problem (BVP) is solved to estimate the free surface vertical velocity using the spectral approach, with typical values of NT between 5 to 8 for practical applications. The 1DH version of the code is validated with comparisons to the experimental data set of Becq-Girard et al. (1999), which studied the propagation of irregular waves over a beach profile with a submerged bar. The nonlinear and dispersive capacities of the model are verified with the correct representation of wave-wave interactions, in particular the transfer of energy between different harmonic components during wave propagation (analysis of the transformation of the variance spectrum along the channel). Evolution of wave skewness, asymmetry and kurtosis along the

Antiadenoviral effects of N-chlorotaurine in vitro confirmed by quantitative polymerase chain reaction methods

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Eiichi Uchio

2010-11-01

Full Text Available Eiichi Uchio1, Hirotoshi Inoue1, Kazuaki Kadonosono21Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan; 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, JapanPurpose: Adenoviral keratoconjunctivitis is recognized as one of the major pathogens of ophthalmological nosocomial infection worldwide. N-Chlorotaurine (Cl–HN–CH2–CH2–SO3H, NCT is the N-chloro derivative of the amino acid taurine, which is an oxidant produced by human granulocytes and monocytes during inflammatory reactions. Using conventional viral plaque assay, it was previously shown that NCT causes inactivation of several human adenovirus (HAdV serotypes. In this study, we evaluated the antiadenoviral effect of NCT by quantitative polymerase chain reaction (PCR methods.Methods: A549 cells were used for viral cell culture, and HAdV serotypes 3, 4, 8, 19, and 37 were used. After calculating 50% cytotoxic concentration (CC50 of NCT by MTS (3-(4,5-dimethylthiazol-2-yl-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl-2H-tetrazolium method, HAdV was cultured with NCT for 7 days, and extracted adenoviral DNA was quantitatively measured by real-time PCR.Results: A statistically significant (P < 0.05 dose-dependent inhibition was indicated for all serotypes except HAdV type 4 (HAdV4, which was maximally inhibited by only ~50%. Among the serotypes, NCT was particularly effective against HAdV8, HAdV19a, and HAdV37. The 50% effective concentration (EC50 obtained by real-time PCR of NCT ranged between 49 and 256 µM. EC50 of NCT against HAdV3 was slightly higher than that against serotypes of species D. The selective index (CC50/EC50 ranged between 41 and 60 except for HAdV4 (11.5.Conclusions: These results show that NCT has an antiviral effect against most serotypes of human HAdV inducing keratoconjunctivitis, indicating its possible therapeutic use.Keywords: adenovirus, N-chlorotaurine, epidemic keratoconjunctivitis, antiviral

Genetic identification of the bacteriocins produced by Enterococcus faecium IT62 and evidence that bacteriocin 32 is identical to enterocin IT.

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Izquierdo, Esther; Cai, Yimin; Marchioni, Eric; Ennahar, Saïd

2009-05-01

Enterococcus faecium IT62, a strain isolated from ryegrass in Japan, produces three bacteriocins (enterocins L50A, L50B, and IT) that have been previously purified and the primary structures of which have been determined by amino acid sequencing (E. Izquierdo, A. Bednarczyk, C. Schaeffer, Y. Cai, E. Marchioni, A. Van Dorsselaer, and S. Ennahar, Antimicrob. Agents Chemother., 52:1917-1923, 2008). Genetic analysis showed that the bacteriocins of E. faecium IT62 are plasmid encoded, but with the structural genes specifying enterocin L50A and enterocin L50B being carried by a plasmid (pTAB1) that is separate from the one (pTIT1) carrying the structural gene of enterocin IT. Sequencing analysis of a 1,475-bp region from pTAB1 identified two consecutive open reading frames corresponding, with the exception of 2 bp, to the genes entL50A and entL50B, encoding EntL50A and EntL50B, respectively. Both bacteriocins are synthesized without N-terminal leader sequences. Genetic analysis of a sequenced 1,380-bp pTIT1 fragment showed that the genes entIT and entIM, encoding enterocin IT and its immunity protein, respectively, were both found in E. faecium VRE200 for bacteriocin 32. Enterocin IT, a 6,390-Da peptide made up of 54 amino acids, has been previously shown to be identical to the C-terminal part of bacteriocin 32, a 7,998-Da bacteriocin produced by E. faecium VRE200 whose structure was deduced from its structural gene (T. Inoue, H. Tomita, and Y. Ike, Antimicrob. Agents Chemother., 50:1202-1212, 2006). By combining the biochemical and genetic data on enterocin IT, it was concluded that bacteriocin 32 is in fact identical to enterocin IT, both being encoded by the same plasmid-borne gene, and that the N-terminal leader peptide for this bacteriocin is 35 amino acids long and not 19 amino acids long as previously reported.

Training in peroral endoscopic myotomy (POEM for esophageal achalasia

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Eleftheriadis N

2012-07-01

Full Text Available Nicholas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Toshihisa Hosoya, Roberta Maselli, Shin-ei KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, JapanAbstract: Peroral endoscopic myotomy (POEM has been developed in the context of natural orifice transluminal endoscopic surgery (NOTES as a minimally invasive endoscopic treatment for symptomatic esophageal achalasia, which is a chronic progressive benign disease with severe morbidity and difficult management. Since September 2008, POEM has been successfully performed in more than 200 consecutive patients with symptomatic achalasia at the Digestive Disease Center of Showa University, Northern Yokohama Hospital, Yokohama, Japan, with excellent short- and long-term results and absence of serious complications. International experience of POEM within clinical studies is also promising. According to these results, POEM is considered as a safe procedure that can be applied to all achalasia patients. However, the low incidence of achalasia (0.3%–1% per 100,000 population, in combination with the potential serious complications related to the technically demanding POEM procedure, has made training difficult. There is therefore an urgent need for an animal model for training to decrease the learning curve. Further, there are other ethical and training issues to address. The pig is the most appropriate animal model for training in POEM due to its anatomy being similar to that of humans. The porcine esophagus has the advantage of easy mobilization due to absence of tight junctions to surrounding organs. A non-survival porcine model would be a simple, inexpensive, and reproducible animal model for training in POEM, without the need for concern about complications. A possible training process might first involve observation of POEM performed by specialists, then training on non-survival and survival porcine models, followed by training in

Flavor Physics & CP Violation 2015

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by Inoue Foundation for Science.

Perceptions and impact of bipolar disorder in Japan: results of an Internet survey

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Watanabe K

2016-11-01

Full Text Available Koichiro Watanabe,1 Eiji Harada,2 Takeshi Inoue,3 Yuka Tanji,2 Toshiaki Kikuchi1 1Department of Neuropsychiatry, Kyorin University, School of Medicine, Tokyo, 2Medical Science, Medicines Development Unit-Japan, Eli Lilly Japan KK, Hyogo, 3Department of Psychiatry, Tokyo Medical University, Tokyo, Japan Abstract: Bipolar disorder is a recurrent and episodic illness. This survey study assessed experiences and identified clinical insights of individuals with bipolar disorder. An Internet-based monitor system database was screened for patients with bipolar disorder in Japan (February and March 2013. Of 1,050 patients, 457 completed surveys, and results were analyzed with descriptive statistics. Approximately one-fourth of respondents were diagnosed with bipolar disorder on their first visit to medical institutions, although the most common initial diagnosis was depression/depressive state (65%. Mean time lag between first-time visit to a medical institution and receipt of correct diagnosis of bipolar disorder was 4 years; one-third of patients experienced more than 5 years of lag time. Three perceived reasons for lapsed time before correct diagnosis were “(patients Did not consider manic symptoms as illness, and did not tell the doctor about them,” “I (patient did not know of bipolar disorder,” and “Lack of communication between my doctor and myself (patient.” Among participants who believed that they were initially incorrectly diagnosed and improperly treated, most experienced socioeconomic problems, such as having long-term inability to work or to study (65%. Sources of encouragement for participants included “To have someone to consult with” (41% followed by having “People around me treat me the same as before” (40%. Individuals with bipolar disorder reported a time lag of many years before accurate diagnosis, and substantial burden imposed by the illness. Encouragement should be provided for individuals to live positively

Endoscopy-guided vitreoretinal surgery following penetrating corneal injury: a case report

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Motoko Kawashima

2010-08-01

Full Text Available Motoko Kawashima1, Shinichi Kawashima2, Murat Dogru1,3, Makoto Inoue4, Jun Shimazaki1,51Department of Ophthalmology, Tokyo Dental College, Chiba, Japan; 2Department of Ophthalmology, International University of Health and Welfare, Tokyo, Japan; 3Department of Ocular Surface and Visual Optics, Keio University School of Medicine, Tokyo, Japan; 4Kyorin Eye Center, Tokyo, Japan; 5Department of Ophthalmology, Keio University School of Medicine, Tokyo, JapanIntroduction: Severe ocular trauma requires emergency surgery, and a fresh corneal graft may not always be available. We describe a case of perforating eye injury with corneal ­opacity, suspected endophthalmitis, and an intraocular foreign body. The patient was successfully treated with a two-step procedure comprising endoscopy-guided vitrectomy followed by corneal transplantation. This surgical technique offers a good option to vitrectomy with simultaneous keratoplasty in emergency cases where no graft is immediately available and there is the ­possibility of infection due to the presence of a foreign body.Case presentation: A 55-year-old Japanese woman was referred to our hospital with a ­perforating corneal and lens injury sustained with a muddy ferrous rod. Primary corneal sutures and lensectomy were performed immediately. Vitreoretinal surgery was required due to ­suspected endophthalmitis, vitreous hemorrhage, retinal detachment, dialysis and necrosis of the peripheral retina. Instead of conventional vitrectomy, endoscopy-guided vitreous surgery was performed with the Solid Fiber Catheter AS-611 (FiberTech, Tokyo, Japan due to the presence of corneal opacity and the unavailability of a donor cornea. The retina was successfully attached with the aid of a silicon oil tamponade. Following removal of the silicon oil at 3 months after surgery, penetrating keratoplasty and intraocular lens implantation with ciliary sulcus suture fixation were performed. At 6 months after penetrating

Effect of the coadministration of citalopram with mirtazapine or atipamezole on rat contextual conditioned fear

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Masuda T

2014-02-01

Full Text Available Takahiro Masuda,1,2 Takeshi Inoue,1 Yan An,1 Naoki Takamura,1,3 Shin Nakagawa,1 Yuji Kitaichi,1 Tsukasa Koyama,1 Ichiro Kusumi1 1Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo Japan; 2Medical Affairs, Dainippon Sumitomo Pharma, Co, Ltd, Tokyo, Japan; 3Regenerative and Cellular Medicine Office, Dainippon Sumitomo Pharma, Co, Ltd, Osaka, Japan Background: Mirtazapine, a noradrenergic and specific serotonergic antidepressant, which blocks the α2-adrenergic autoreceptors and heteroreceptors, has shown anxiolytic properties in clinical trials and preclinical animal experiments. The addition of mirtazapine to selective serotonin reuptake inhibitors (SSRIs is clinically suggested to be more effective for anxiety disorders. In this study, we examined the combined effects of mirtazapine and citalopram, an SSRI, on the freezing behavior of rats, which was induced by contextual conditioned fear as an index of anxiety or fear. Methods: Male Sprague Dawley rats individually received footshocks in a shock chamber, and 24 hours later, they were given citalopram and/or mirtazapine injections. One hour after citalopram and 30 minutes after mirtazapine administration, freezing behavior was analyzed in the same shock chamber without shocks. Results: Mirtazapine decreased freezing in a dose-dependent manner, which is consistent with a previous report; it also enhanced an anxiolytic-like effect at a high dose (30 mg/kg of citalopram. Because mirtazapine blocks α2-adrenoreceptors, the combined effect of atipamezole, a selective α2 receptor antagonist, with citalopram was also examined. Similar to mirtazapine, atipamezole reduced freezing dose-dependently, but the enhancement of citalopram's effects by atipamezole was not clear when compared with mirtazapine. Conclusion: The present findings suggest that mirtazapine has an anxiolytic-like effect and may enhance the anxiolytic-like effect of SSRIs, but this enhancement may not be

Long-term effect of cinacalcet hydrochloride on abdominal aortic calcification in patients on hemodialysis with secondary hyperparathyroidism

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Nakayama K

2013-12-01

Full Text Available Kazunori Nakayama,1,2 Kazushi Nakao,1,2 Yuji Takatori,1,2 Junko Inoue,1 Shoichirou Kojo,1 Shigeru Akagi,1,2 Masaki Fukushima,2 Jun Wada,1 Hirofumi Makino11Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2Shigei Medical Research Hospital, Okayama, JapanBackground: Secondary hyperparathyroidism (SHPT is one of the common complications in dialysis patients, and is associated with increased risk of vascular calcification. The effects of cinacalcet hydrochloride treatment on bone and mineral metabolism have been previously reported, but the benefit of cinacalcet on vascular calcification remains uncertain. The aim of this study was to evaluate the impact of cinacalcet on abdominal aortic calcification in dialysis patients.Subjects and methods: Patients were on maintenance hemodialysis with insufficiently controlled SHPT (intact parathyroid hormone [PTH] >180 pg/mL by conventional therapies. All subjects were initially administered 25 mg cinacalcet daily, with concomitant use of calcitriol analogs. Abdominal aortic calcification was annually evaluated by calculating aortic calcification area index (ACAI using multidetector computed tomography (MDCT, from 12 months before to 36 months after the initiation of cinacalcet therapy.Results: Twenty-three patients were analyzed in this study. The mean age was 59.0±8.7 years, 34.8% were women, and the mean dialysis duration was 163.0±76.0 months. After administration of cinacalcet, serum levels of intact PTH, phosphorus, and calcium significantly decreased, and mean Ca × P values significantly decreased from 67.4±7.9 mg2/dL2 to 52±7.7 mg2/dL2. Although the ACAI value did not decrease during the observation period, the increase in ACAI between 24 months and 36 months after cinacalcet administration was significantly suppressed.Conclusion: Long-term administration of cinacalcet was associated with reduced progression of

New Carbonate Standard Reference Materials for Boron Isotope Geochemistry

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Stewart, J.; Christopher, S. J.; Day, R. D.

2015-12-01

The isotopic composition of boron (δ11B) in marine carbonates is well established as a proxy for past ocean pH. Yet, before palaeoceanographic interpretation can be made, rigorous assessment of analytical uncertainty of δ11B data is required; particularly in light of recent interlaboratory comparison studies that reported significant measurement disagreement between laboratories [1]. Well characterised boron standard reference materials (SRMs) in a carbonate matrix are needed to assess the accuracy and precision of carbonate δ11B measurements throughout the entire procedural chemistry; from sample cleaning, to ionic separation of boron from the carbonate matrix, and final δ11B measurement by multi-collector inductively coupled plasma mass spectrometry. To date only two carbonate reference materials exist that have been value-assigned by the boron isotope measurement community [2]; JCp-1 (porites coral) and JCt-1 (Giant Clam) [3]. The National Institute of Standards and Technology (NIST) will supplement these existing standards with new solution based inorganic carbonate boron SRMs that replicate typical foraminiferal and coral B/Ca ratios and δ11B values. These new SRMs will not only ensure quality control of full procedural chemistry between laboratories, but have the added benefits of being both in abundant supply and free from any restrictions associated with shipment of biogenic samples derived from protected species. Here we present in-house δ11B measurements of these new boron carbonate SRM solutions. These preliminary data will feed into an interlaboratory comparison study to establish certified values for these new NIST SRMs. 1. Foster, G.L., et al., Chemical Geology, 2013. 358(0): p. 1-14. 2. Gutjahr, M., et al., Boron Isotope Intercomparison Project (BIIP): Development of a new carbonate standard for stable isotopic analyses. Geophysical Research Abstracts, EGU General Assembly 2014, 2014. 16(EGU2014-5028-1). 3. Inoue, M., et al., Geostandards and

Process of spontaneous resolution in the conservative management of congenital dacryocystocele

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Mimura M

2014-02-01

Full Text Available Masashi Mimura,1,2 Mari Ueki,1 Hidehiro Oku,1 Bunpei Sato,2 Tsunehiko Ikeda11Department of Ophthalmology, Osaka Medical College, Takatsuki, 2Department of Ophthalmology, Osaka Kaisei Hospital, Osaka, JapanPurpose: To assess efficacy of the conservative management of patients with congenital dacryocystocele.Materials and methods: This was a retrospective case series involving six sides of five infants with a dacryocystocele treated at Osaka Kaisei Hospital, Osaka, Japan. The conservative management protocol consisted of the application of warm compresses and massage over the mass, with the addition of antibiotics when dacryocystitis developed. Patient age at the time of resolution, presence of retrograde outflow of contents of dacryocystoceles from the puncta, and development of dacryocystitis were recorded.Results: The dacryocystocele was unilateral in four patients and bilateral in one patient. A nasal cyst was present in four patients without respiratory distress. The median patient age at the time of the diagnosis was 7 days (range 2–10 days. Conservative management was selected in all patients, and the dacryocystocele was resolved in all patients at a median patient age of 14.5 days (range 11–105 days. Two sides developed dacryocystitis, which resolved in a few days with antibiotic treatment. In those two sides, rupture of the dacryocystoceles to the common canaliculus with retrograde discharge of the contents from the puncta before the dacryocystitis developed was noted. For the other four treated sides, no such discharge or development of dacryocystitis was observed.Conclusion: The findings of this study show that a dacryocystocele has a good chance of resolving spontaneously with conservative management and careful observation, and that rupture of the dacryocystocele to the common canaliculus might be an important precursor of dacryocystitis.Keywords: dacryocystitis, congenital lacrimal obstruction, remnant, precursor, retrograde

Influência da embalagem de atmosfera modificada e do tratamento com cálcio na cinética de degradação de ácido ascórbico e perda de massa em goiabas (Psidium guajava L.

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YAMASHITA Fábio

2000-01-01

Full Text Available Goiabas de mesa (var. Pedro Sato no estádio verde maturo foram armazenadas a 8°C (85-95% UR por 49 dias. Uma parte das amostras foi tratada com solução de cloreto de cálcio 2% (p/v e o restante permaneceu sem tratamento. Posteriormente, foram embaladas individualmente em dois tipos de embalagem de atmosfera modificada (CryovacÒ PD-900 e CryovacÒ PD-961. Goiabas sem embalagem e não tratadas com cálcio, mantidas à mesma temperatura de 8°C serviram como controle. Foram realizadas análises de perda de massa, acidez titulável, teores de sólidos solúveis totais e ácido ascórbico. Os frutos embalados apresentaram taxas de perda de massa menores que os sem embalagem (p<0,05. Os frutos tratados com cálcio não apresentaram diferença na taxa de degradação de ácido ascórbico em relação aos não tratados e os frutos embalados com PD-900 apresentaram retenção de ácido ascórbico maior. Após 4 semanas, as goiabas sem embalagem apresentaram-se impróprias para consumo, devido ao murchamento e ataque de fungos, enquanto que as embaladas estavam em bom estado. Após a sexta semana, apenas os frutos embalados com PD-900 sem tratamento com cálcio estavam próprios para consumo. A embalagem de atmosfera modificada reduziu a perda de massa e ácido ascórbico e prolongou a vida-de-prateleira do produto. O emprego de cálcio não afetou as características analisadas.

Poly[μ2-chlorido-nonamethyl-μ3-nitrato-tritin(IV]. Corrigendum

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Madeleine Helliwell

2008-07-01

Full Text Available An error in the original formulation of the title compound in the paper by Sadiq-ur-Rehman, Sherzaman, Ali, Shahzadi & Helliwell [Acta Cryst. (2007, E63, m2329] is corrected.The title compound in the paper by Sadiq-ur-Rehman, Sherzaman, Ali, Shahzadi & Helliwell [Acta Cryst. (2007, E63, m2329] was an unexpected product which seemed to have nitrate coordinated to three Sn atoms. However, it was noticed that the charges do not balance and that it is most likely that the nitrate is in fact a carbonate. Regrettably, there is no material to carry out microanalysis, but a plausible mechanism has been suggested to explain the unexpected formation of the product. Trimethyltin chloride will react with methanol in the presence of a base (4-hydroxypiperidine to give trimethyltin methoxide, which will rapidly hydrolyze in air to give the hydroxide. Both the methoxide and the hydroxide will react with atmospheric CO2 to give the carbonate (Bloodworth et al., 1967; Blunden et al., 1984; Sato, 1967. Me3SnCl + MeOH + base → Me3SnOMe + base·HCl Me3SnOMe + H2O → Me3SnOH + MeOH Me3SnOH + CO2 → Me3SnOCO2HMe3SnOCO2H + Me3SnOMe → Me3SnOCO2SnMe3 + MeOH. The carbonate then forms a coordination copolymer with trimethyltin chloride. The name of the title compound is corrected to poly[μ3-carbonato-μ3-chlorido-nonamethyltritin(IV], [Sn3(CH39(CO3Cl] (Mr = 586.84.

The use of biotopes in assessing the environmental quality of tidal estuaries in Europe

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Ducrotoy, Jean-Paul

2010-02-01

In Europe, the Water Framework Directive (WFD) (European Commission 2000) - and the recently proposed EU Marine Strategy Directive - have established a framework for the protection of groundwater, inland surface waters, estuarine (transitional) waters and coastal waters. TheWFD has several objectives: to prevent water ecosystem deterioration, to protect and to enhance the status of water resources but the most important aspect is to achieve a 'Good Ecological Status' (GES) for all waters, by 2015. In essence, the WFD requires a water body to be compared against a reference condition and then its ecological status designated - if the water body does not meet good or high ecological status, i.e. it is in moderate, poor or bad ecological status, then remedial measures have to be taken (e.g. pollution has to be removed). Many indices were developed from benthic work and are often thought fit for purpose. Based on the successional model proposed by Pearson and Rosenberg (1978), most of these indices were effectively established for soft sediment benthos. However, those developed in the framework of the WFD were derived from work on the subtidal. They are difficult to use in the intertidal and in transitional waters. As they were derived from work on organic pollution, there is no or little evident link with chemical and physical pollution. Ecomorphology brings together a biological approach and a sedimentological approach to estuarine ecology. It considers the use of the biotope and related concepts (biocenosis, bio-facies, ecotone, habitat…) as a basis to a novel approach to environmental quality assessment. It addresses the problem of the estuarine quality paradox in recognising the role of nutrients and organic matter in biogeochemical cycles. The discussion shows the complementarity of biotopes with the Sato-Umi and the ecohydrolgy approaches.

Celecoxib does not significantly delay bone healing in a rat femoral osteotomy model: a bone histomorphometry study

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Iwamoto J

2011-12-01

Full Text Available Jun Iwamoto1, Azusa Seki2, Yoshihiro Sato3, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Hamri Co, Ltd, Tokyo, Japan; 3Department of Neurology, Mitate Hospital, Fukuoka, JapanBackground and objective: The objective of the present study was to determine whether celecoxib, a cyclo-oxygenase-2 inhibitor, would delay bone healing in a rat femoral osteotomy model by examining bone histomorphometry parameters.Methods: Twenty-one 6-week-old female Sprague-Dawley rats underwent a unilateral osteotomy of the femoral diaphysis followed by intramedullary wire fixation; the rats were then divided into three groups: the vehicle administration group (control, n = 8, the vitamin K2 administration (menatetrenone 30 mg/kg orally, five times a week group (positive control, n = 5, and the celecoxib administration (4 mg/kg orally, five times a week group (n = 8. After 6 weeks of treatment, the wires were removed, and a bone histomorphometric analysis was performed on the bone tissue inside the callus. The lamellar area relative to the bone area was significantly higher and the total area and woven area relative to the bone area were significantly lower in the vitamin K2 group than in the vehicle group. However, none of the structural parameters, such as the callus and bone area relative to the total area, lamellar and woven areas relative to the bone area, or the formative and resorptive parameters such as osteoclast surface, number of osteoclasts, osteoblast surface, osteoid surface, eroded surface, and bone formation rate per bone surface differed significantly between the vehicle and celecoxib groups.Conclusion: The present study implies that celecoxib may not significantly delay bone healing in a rat femoral osteotomy model based on the results of a bone histomorphometric analysis.Keywords: femoral osteotomy, bone healing, callus, rat, celecoxib

Introduction to the special issue on recent advances and developments in atmospheric electricity

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Cheng-Ling Kuo

2017-01-01

Full Text Available The special issue highlights the state of research efforts on the atmospheric electricity in Asia, particularly in Taiwan, China and Japan. In some ways, this can also be viewed as a commemorative issue for the ISUAL/FORMOSAT2 experiment, which officially ended its mission in July 2016. The first breakthrough on atmospheric electricity research in Taiwan was achieved through ground campaigns, including the investigations of transient luminous events (TLEs near the vicinity of Taiwan (Su et al. 2002; Hsu et al. 2003 and gigantic jet (Su et al. 2003. From 2004 - 2016, the satellite mission of ISUAL (Imager of Sprite/Upper Atmospheric Lightning onboard the FORMOSAT2 satellite was conducted, and a few important results are reported in (Hsu et al. 2017; this issue. The ISUAL mission is a successful international cooperation between Taiwan, USA and Japan (Chern et al. 2003; Su et al. 2005; Chen et al. 2008. The past and current TLE scientific missions include the Mediterranean Israeli Dust Experiment (MEIDEX sprite campaign onboard the space shuttle Columbia in 2003 (Yair et al. 2003, a Japanese micro satellite SPRITE-SAT (2010- (Takahashi et al. 2010, the Japan mission Global Lightning and Sprite Measurements on Japanese Experiment Module (JEM-GLIMS on the International Space Station (ISS from 2011 (Sato et al. 2015, 2017, NASA Crew Earth Observation program (2011 - 2012 (Jehl et al. 2013, and the Iriss mission by Denmark’s first astronaut, Andreas Mogensen on the ISS (Chanrion et al. 2017. The upcoming orbit missions including ASIM (Atmosphere-Space Interaction Monitor (Neubert 2009 and TARANIS (Tool for the Analysis of RAdiations from lightNIngs and Sprites (Farges et al. 2017. The ISUAL mission besides being a pioneer atmospheric electricity program, also is a historic space platform dedicating to the study of TLEs in the middle atmosphere (Hsu et al. 2017; this issue.

Significance of downregulation of renal organic cation transporter (SLC47A1 in cisplatin-induced proximal tubular injury

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Mizuno T

2015-07-01

Full Text Available Tomohiro Mizuno,1–3 Waichi Sato,2,3 Kazuhiro Ishikawa,4 Yuki Terao,1 Kazuo Takahashi,2 Yukihiro Noda,5 Yukio Yuzawa,2 Tadashi Nagamatsu1 1Department of Analytical Pharmacology, Meijo University Faculty of Pharmacy, Nagoya, 2Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, 3Department of Nephrology, Nagoya University School of Medicine, Nagoya, 4Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, 5Division of Clinical Sciences and Neuropsychopharmacology, Meijo University Faculty of Pharmacy, Nagoya, Japan Background/aim: To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1 in tubular cells. Materials and methods: To detect changing expression of MATE1/SLC47A1 in dose- and time-dependent manners, human proximal tubular epithelial cells were incubated with AGE-aggregated-human serum albumin. As a function assay for MATE1/SLC47A1, human proximal tubular epithelial cells were incubated with cisplatin or carboplatin. Results: On incubation with AGEs, the expressions of MATE1/SLC47A1 were decreased in tubular cells. In addition, the toxicities of cisplatin were increased in tubular cells that had been pretreated with AGEs. However, the toxicities of carboplatin were smaller than that of cisplatin in proximal tubular epithelial cells. Conclusion: The expression of the MATE1/SLC47A1 is decreased by AGEs, which increases the risk for proximal tubular injury. Keywords: advanced glycation endproducts, cisplatin, SLC47A1, diabetes mellitus, acute kidney injury

Simulation of tectonic evolution of the Kanto basin of Japan since 1 Ma due to subduction of the Pacific and Philippine sea plates and collision of the Izu-Bonin arc

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Hashima, Akinori; Sato, Toshinori; Sato, Hiroshi; Asao, Kazumi; Furuya, Hiroshi; Yamamoto, Shuji; Kameo, Koji; Miyauchi, Takahiro; Ito, Tanio; Tsumura, Noriko; Kaneda, Heitaro

2015-04-01

The Kanto basin, the largest lowland in Japan, developed by flexure as a result of (1) the subduction of the Philippine Sea (PHS) and the Pacific (PAC) plates and (2) the collision of the Izu-Bonin arc with the Japanese island arc. Geomorphological, geological, and thermochronological data on long-term vertical movements over the last 1 My suggest that subsidence initially affected the entire Kanto basin after which the area of subsidence gradually narrowed until, finally, the basin began to experience uplift. In this study, we modelled the tectonic evolution of the Kanto basin following the method of Matsu'ura and Sato (1989) for a kinematic subduction model with dislocations, in order to quantitatively assess the effects of PHS and PAC subduction. We include the steady slip-rate deficit (permanent locking rate at the plate interface) in our model to account for collision process. We explore how the arc-arc collision process has been affected by a westerly shift in the PHS plate motion vector with respect to the Eurasian plate, thought to have occurred between 1.0-0.5 Ma, using long-term vertical deformation data to constrain extent of the locked zone on the plate interface. We evaluated the change in vertical deformation rate for two scenarios: (1) a synchronous shift in the orientation of the locked zone as PHS plate motion shifts and (2) a delayed shift in the orientation of the locked zone following a change in plate motion. Observed changes in the subsidence/uplift pattern are better explained by scenario (2), suggesting that recent (<1 My) deformation in the Kanto basin shows a lag in crustal response to the shift in plate motion. We also calculated recent stress accumulation rates and found a good match with observed earthquake mechanisms, which shows that intraplate earthquakes serve to release stress accumulated through long-term plate interactions.

Simulation of tectonic evolution of the Kanto Basin of Japan since 1 Ma due to subduction of the Pacific and Philippine Sea plates and the collision of the Izu-Bonin arc

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Hashima, Akinori; Sato, Toshinori; Sato, Hiroshi; Asao, Kazumi; Furuya, Hiroshi; Yamamoto, Shuji; Kameo, Koji; Miyauchi, Takahiro; Ito, Tanio; Tsumura, Noriko; Kaneda, Heitaro

2016-06-01

The Kanto Basin, the largest lowland in Japan, developed by flexure as a result of (1) the subduction of the Philippine Sea (PHS) and the Pacific (PAC) plates and (2) the repeated collision of the Izu-Bonin arc fragments with the Japanese island arc. Geomorphological, geological, and thermochronological data on vertical movements over the last 1 My suggest that subsidence initially affected the entire basin after which the area of subsidence gradually narrowed until, finally, the basin began to experience uplift. In this study, we modeled the tectonic evolution of the Kanto Basin following the method of Matsu'ura and Sato (1989) for a kinematic subduction model with dislocations, in order to quantitatively assess the effects of PHS and PAC subduction. We include the steady slip-rate deficit (permanent locking rate at the plate interface) in our model to account for collision process. We explore how the latest collision of the Izu Peninsula block has been affected by a westerly shift in the PHS plate motion vector with respect to the Eurasian plate, thought to have occurred between 1.0-0.5 Ma, using long-term vertical deformation data to constrain extent of the locked zone on the plate interface. We evaluated the change in vertical deformation rate for two scenarios: (1) a synchronous shift in the orientation of the locked zone as PHS plate motion shifts and (2) a delayed shift in the orientation of the locked zone following the shift in plate motion. Observed changes in the uplift/subsidence pattern are better explained by scenario (2), suggesting that recent (< 1 My) deformation in the Kanto Basin shows a lag in crustal response to the plate motion shift. We also calculated stress accumulation rates and found a good match with observed earthquake mechanisms, which shows that intraplate earthquakes serve to release stress accumulated through long-term plate interactions.

Avaliação dos parâmetros gasométricos dos traumatizados durante o atendimento pré-hospitalar móvel

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Ricardo Alessandro Teixeira Gonsaga

Full Text Available OBJETIVO: avaliar diferenças gasométricas dos pacientes traumatizados graves que necessitaram de intubação orotraqueal no atendimento pré-hospitalar. MÉTODOS: foram colhidas amostras de sangue dos pacientes que necessitaram de manejo de via aérea no início do atendimento pré-hospitalar e ao dar entrada na Unidade de Urgência. Foram analisados: pH, pressão arterial de CO2 (PaCO2, pressão arterial de O2 (PaO2, excesso de base (BE, saturação da hemoglobina por O2 (satO2 e a relação PaO2 e a fração inspirada de O2 (PaO2/FiO2. RESULTADOS: houve significância estatística entre as diferenças das médias entre os dados coletados no local do sinistro e na entrada da UUE na Frequência respiratória (p=0,0181, na Escala de Coma de Glasgow (p=0,0084, na pressão parcial arterial de oxigênio (PaO2; p<0,0001 e na saturação da hemoglobina pelo oxigênio (p=0,0018. CONCLUSÃO: a intubação orotraqueal altera os parâmetros PaO2 e saturação de oxigênio pela hemoglobina. Não houve diferença nos parâmetros metabólicos (pH, Bicarbonato e excesso de base. Na análise dos parâmetros hemogasométricos dos sobreviventes e não sobreviventes observou-se diferença estatística entre o PaO2, saturação de oxigênio pela hemoglobina e excesso de base.

Implementation of a one-group interfacial area transport equation in a CFD code for the simulation of upward adiabatic bubbly flow

International Nuclear Information System (INIS)

Pellacani, F.; Macian, R.; Chiva, S.; Pena, C.

2011-01-01

In this paper upward, isothermal and turbulent bubbly flow in tubes is numerically modeled by using ANSYS CFX 12.1 with the aim of creating a basis for the reliable simulation of the flow along a vertical channel in a nuclear reactor as long term goal. Two approaches based on the mono-dispersed model and on the one-group Interfacial Area Transport Equation (IATE) model are used in order to maintain the computational effort as low as possible. This work represents the necessary step to implement a two-group interfacial area transport equation that will be able to dynamically represent the changes in interfacial structure in the transition region from bubbly to slug flow. The drag coefficient is calculated using the Grace model and the interfacial non-drag forces are also included. The Antal model is used for the calculation of the wall lubrication force coefficient. The lift force coefficient is obtained from the Tomiyama model. The turbulent dispersion force is taken into account and is modeled using the FAD (Favre averaged drag) approach, while the turbulence transfer is simulated with the Sato's model. The liquid velocity is in the range between 0.5 and 2 m/s and the average void fraction varies between 5 and 15%.The source and sink terms for break-up and coalescence needed for the calculation of the implemented Interfacial Area Density are those proposed by Yao and Morel. The model has been checked using experimental results by Mendez. Radial profile distributions of void fraction, interfacial area density and bubble mean diameter are shown at the axial position equivalent to z/D=56. The results obtained by the simulations have a good agreement with the experimental data but show also the need of a better study of the coalescence and breakup phenomena to develop more accurate interaction models. (author)

Use of Recombinant Antigens for Sensitive Serodiagnosis of American Tegumentary Leishmaniasis Caused by Different Leishmania Species.

Science.gov (United States)

Sato, Camila Massae; Sanchez, Maria Carmen Arroyo; Celeste, Beatriz Julieta; Duthie, Malcolm S; Guderian, Jeffrey; Reed, Steven G; de Brito, Maria Edileuza Felinto; Campos, Marliane Batista; de Souza Encarnação, Helia Valeria; Guerra, Jorge; de Mesquita, Tirza Gabrielle Ramos; Pinheiro, Suzana Kanawati; Ramasawmy, Rajendranath; Silveira, Fernando Tobias; de Assis Souza, Marina; Goto, Hiro

2017-02-01

American tegumentary leishmaniasis (ATL) (also known as cutaneous leishmaniasis [CL]) is caused by various species of protozoa of the genus Leishmania The diagnosis is achieved on a clinical, epidemiological, and pathological basis, supported by positive parasitological exams and demonstration of leishmanin delayed-type hypersensitivity. Serological assays are not routinely used in the diagnosis because many are considered to have low sensitivity and the particular Leishmania species causing the disease can lead to variable performance. In the present study, we generated recombinant versions of two highly conserved Leishmania proteins, Leishmania (Viannia) braziliensis-derived Lb8E and Lb6H, and evaluated both in enzyme-linked immunosorbent assays (ELISA). Recombinant Lb6H (rLb6H) had better performance and reacted with 100.0% of the ATL and 89.4% of the VL samples. These reactions with rLb6H were highly specific (98.5%) when compared against those for samples from healthy control individuals. We then assessed rLb6H against sera from ATL patients infected with different species of Leishmania prevalent in Brazil [Leishmania (Leishmania) amazonensis, L (Viannia) braziliensis, and L (V) guyanensis] and samples from patients with other infectious diseases. In analyses of 500 sera, ELISA using rLb6H detected all 219 ATL samples (sensitivity of 100.0%) with an overall specificity of 93.9% (considering healthy individuals and other infectious diseases patients). Only a minority of samples from Chagas disease patients possessed antibodies against rLb6H, and all of these responses were low (with a highest reactivity index of 2.2). Taken together, our data support further evaluation of rLb6H and the potential for its routine use in the serological diagnosis of ATL. Copyright © 2017 Sato et al.

Influence of body mass index and type of low-level exercise on the side effect profile of regadenoson

International Nuclear Information System (INIS)

Salgado-Garcia, Carlos; Jimenez-Heffernan, Amelia; Lopez-Martin, Juana; Molina-Mora, Manuela; Aroui, Tarik; Sanchez de Mora, Elena; Ramos-Font, Carlos; Rivera de los Santos, Francisco; Ruiz-Frutos, Carlos

2017-01-01

Regadenoson, an A_2_A adenosine receptor pharmacologic stress agent for radionuclide myocardial perfusion imaging (MPI), is administered as a single, fixed dose. We studied the side effect profile of regadenoson combined with two types of low-level exercise, according to body mass index (BMI). Three hundred and fifty-six patients (46.1% men, mean age 67.7±10.7 years, range 31-90 years) underwent regadenoson stress testing combined with low-level exercise. Subjects were classified according to BMI as normal, overweight, or obese, and the type of low-level exercise performed as walking on the treadmill (TE group, n=190) or forcefully swinging legs while sitting (SS group, n=166). Patients' demographics, medical history, clinical symptoms during stress, changes in ECG, oxygen saturation (SatO_2), systolic blood pressure (SBP), and heart rate (HR) were evaluated. Groups were comparable (p=ns) with regard to cardiovascular risks factors. The incidence of side effects was similar across BMI (p=ns), although the TE patients showed improved profiles over those with SS exercise, with a significantly lower incidence of flushing, dizziness and nausea/gastrointestinal discomfort (12.9% vs. 28.4%; 19.9% vs. 33.4%; 11.4% vs. 19.2%, respectively; all p<0.05). Regarding the hemodynamic response, we did not observe significant changes in SBP and HR after regadenoson administration across BMI categories. Comparing the TE and SS groups, no significant changes were observed in SBP, but there was a higher increase in HR in the TE group (p<0.05). Regadenoson in combination with low-level exercise is safe and well tolerated over a wide range of BMI, with TE exercise showing a better side effect profile than SS. (orig.)

The Divisia real energy intensity indices: Evolution and attribution of percent changes in 20 European countries from 1995 to 2010

International Nuclear Information System (INIS)

Fernández González, P.; Landajo, M.; Presno, M.J.

2013-01-01

This paper analyzes the evolution of real energy efficiency in the European Union and the attribution across countries of its percent change. Relying on a multiplicative energy intensity approach that is implemented through the Sato-Vartia Logarithmic Mean Divisia Index method, we decompose the change in aggregate energy intensity in 20 European countries for the period from 1995 to 2010. A comparative analysis of real energy intensity indices is also carried out. In addition, a new tool to monitor changes in real energy intensity in greater detail is applied. The attribution analysis of IDA (Index Decomposition Analysis) as proposed by Choi and Ang (Choi KH, Ang BW. Attribution of changes in Divisia real energy intensity index – an extension to index decomposition analysis. Energy Economics 2012;34:171–6) is used in order to assess the contribution of each individual sector to the percent change in real energy intensity. Results indicate that the European countries, particularly the former communist ones, made a remarkable effort to improve energy efficiency. Our analysis also suggests some strategies –including promotion and adaptation to more efficient techniques, innovation, improved use of technologies, R and D, and substitution for higher quality energies-, which are of particular interest to the industry sector -including construction- in ex-communist EU members, and to the industry and transport plus hotels and restaurants sectors in Western countries. - Highlights: • We apply a single and multi-period attribution analysis approach [1]. • Technical change, improved use of tech and quality energies, keys to AEI drop. • Real energy intensity shows valuable progress in former communist European members. • The biggest attribution of percent change in real energy intensity was to Industry. • Western EU: Services and Agriculture poor contributors to real energy intensity drop

Modeling of high‐frequency seismic‐wave scattering and propagation using radiative transfer theory

Science.gov (United States)

Zeng, Yuehua

2017-01-01

This is a study of the nonisotropic scattering process based on radiative transfer theory and its application to the observation of the M 4.3 aftershock recording of the 2008 Wells earthquake sequence in Nevada. Given a wide range of recording distances from 29 to 320 km, the data provide a unique opportunity to discriminate scattering models based on their distance‐dependent behaviors. First, we develop a stable numerical procedure to simulate nonisotropic scattering waves based on the 3D nonisotropic scattering theory proposed by Sato (1995). By applying the simulation method to the inversion of M 4.3 Wells aftershock recordings, we find that a nonisotropic scattering model, dominated by forward scattering, provides the best fit to the observed high‐frequency direct S waves and S‐wave coda velocity envelopes. The scattering process is governed by a Gaussian autocorrelation function, suggesting a Gaussian random heterogeneous structure for the Nevada crust. The model successfully explains the common decay of seismic coda independent of source–station locations as a result of energy leaking from multiple strong forward scattering, instead of backscattering governed by the diffusion solution at large lapse times. The model also explains the pulse‐broadening effect in the high‐frequency direct and early arriving S waves, as other studies have found, and could be very important to applications of high‐frequency wave simulation in which scattering has a strong effect. We also find that regardless of its physical implications, the isotropic scattering model provides the same effective scattering coefficient and intrinsic attenuation estimates as the forward scattering model, suggesting that the isotropic scattering model is still a viable tool for the study of seismic scattering and intrinsic attenuation coefficients in the Earth.

Two-fluid model LES of a bubble column

International Nuclear Information System (INIS)

Brahma N Reddy Vanga; Martin A Lopez de Bertodano; Eckhard Krepper; Alexandr Zaruba; Horst-Michael Prasser

2005-01-01

The hydrodynamics of a rectangular bubble column operating in the dispersed bubbly regime has been numerically investigated using a two-fluid model Large Eddy Simulation (LES). Experimental data were obtained to validate the model. LES computational fluid dynamic calculations of the transient flow for the bubble column were performed to account for the turbulence in the liquid phase. The computational mesh is of the same scale as the bubble size. The sub grid-scale Reynolds stresses were calculated with the Smagorinsky model. Furthermore, the effect of the bubbles on the turbulence in the continuous phase was modeled using Sato's eddy viscosity model for bubble-induced turbulence. Mean quantities were computed by averaging over a time period that was longer than the dynamic time scales of the turbulence, in particular the void fraction and the average velocity of the bubbles. A systematic analysis of the effect of the interfacial momentum transfer terms on these quantities has been conducted. The bubble column was locally aerated using a sparger located in the center of the bottom plate. The experimental studies involve wire-mesh tomography measurements for void fraction and bubble size distributions and digital image processing of high speed camera images for estimation of bubble velocities, size distributions and flow patterns. Experiments were performed for various aspect ratios (height of water column to width ratio) and superficial gas velocities. It was found that the non-drag bubble forces play a very prominent role in the predicting the correct flow pattern and void fraction distributions. In the calculations, the lift force and the wall force were considered. A 'wall peak' in the time averaged void fraction distribution has been experimentally observed and this cannot be predicted without including these non-drag forces in the numerical calculations. In this paper, experimental data are compared with the results of the numerical simulations. (authors)

Klotho expression in long bones regulates FGF23 production during renal failure.

Science.gov (United States)

Kaludjerovic, Jovana; Komaba, Hirotaka; Sato, Tadatoshi; Erben, Reinhold G; Baron, Roland; Olauson, Hannes; Larsson, Tobias E; Lanske, Beate

2017-05-01

Circulating levels of bone-derived fibroblast growth factor 23 (FGF23) increase early during acute and chronic kidney disease and are associated with adverse outcomes. Membrane-bound Klotho acts as a permissive coreceptor for FGF23, and its expression was recently found in osteoblasts/osteocytes. We hypothesized that Klotho in bone cells is part of an autocrine feedback loop that regulates FGF23 expression during renal failure. Thus, we induced renal failure in mice with targeted deletion of Klotho in long bones. Uremic wild-type ( KL fl/fl ) and knockout ( Prx1-Cre;KL fl/fl ) mice both responded with reduced body weight, kidney atrophy, hyperphosphatemia, and increased bone turnover. Importantly, long bones of Prx1-Cre;KL fl/fl mice but not their axial skeleton failed to increase FGF23 expression as observed in uremic KL fl/fl mice. Consequently, Prx1-Cre;KL fl/fl mice had significantly lower serum FGF23 and parathyroid hormone levels, and higher renal 1-α-hydroxylase expression, serum 1,25-dihydroxyvitamin D, and calcium levels than KL fl/fl mice. These results were confirmed in two independent models of renal failure, adenine diet induced and 5/6 nephrectomy. Moreover, FGF23-treated bone cells required Klotho to increase FGF23 mRNA and ERK phosphorylation. In summary, our novel findings show that Klotho in bone is crucial for inducing FGF23 production upon renal failure. We propose the presence of an autocrine feedback loop in which Klotho senses the need for FGF23.-Kaludjerovic, J., Komaba, H., Sato, T., Erben, R. G., Baron, R., Olauson, H., Larsson, T. E., Lanske, B. Klotho expression in long bones regulates FGF23 production during renal failure. © FASEB.

Influence of treatment with alendronate on the speed of sound, an ultrasound parameter, of the calcaneus in postmenopausal Japanese women with osteoporosis: a clinical practice-based observational study

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Iwamoto J

2012-06-01

Full Text Available Jun Iwamoto,1 Tetsuya Takada,2 Yoshihiro Sato,3 Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, 2Department of Internal Medicine, Hiyoshi Medical Clinic, Kanagawa, 3Department of Neurology, Mitate Hospital, Fukuoka, JapanPurpose: The influence of alendronate (ALN treatment on the quantitative ultrasound parameters of the calcaneus remains to be established in Japanese patients. The aim of the present clinical practice-based observational study was to examine the influence of ALN treatment for 1 year on the speed of sound (SOS of the calcaneus and bone turnover markers in postmenopausal Japanese women with osteoporosis.Patients and methods: Forty-five postmenopausal Japanese women with osteoporosis who had received treatment with ALN for more than 1 year were enrolled in the study. The SOS and bone turnover markers were monitored over 1 year of ALN treatment.Results: The urinary levels of cross-linked N-terminal telopeptides of type I collagen and serum levels of alkaline phosphatase decreased significantly from the baseline values (–44.9% at 3 months and –22.2% at 12 months, respectively. The SOS increased modestly, but significantly, from the baseline value (0.6% at both 6 and 12 months. The percentage decrease in the urinary levels of cross-linked N-terminal telopeptides of type I collagen at 3 months was significantly correlated with the percentage increase in the SOS only at 6 months (correlation coefficient, 0.299.Conclusion: The present study confirmed that ALN treatment suppressed bone turnover, producing a clinically significant increase in the SOS of the calcaneus in postmenopausal Japanese women with osteoporosis.Keywords: postmenopausal osteoporosis, quantitative ultrasound (QUS, SOS, bone turnover, biochemical markers

The clinical course of symptomatic deep vein thrombosis after 3 months of anticoagulant therapy using fondaparinux/edoxaban or fondaparinux/vitamin K antagonist

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Shimizu K

2018-02-01

Full Text Available Kazuhiro Shimizu, Takuo Iiduka, Shuji Sato, Hajime Kiyokawa, Takahiro Nakagami, Hiroshi Mikamo, Masayo Kawazoe, Mao Takahashi, Mahito Noro Department of Internal Medicine, Toho University Sakura Medical Center, Sakura City, Chiba, Japan Background: For the management of venous thromboembolism (VTE, providing anticoagulant therapy within the therapeutic range has been a major challenge, as conventional therapy with unfractionated heparin (UFH and vitamin K antagonist (VKA requires frequent laboratory monitoring and dose adjustment. Recently, fondaparinux and edoxaban are being used as beneficial alternatives to UFH and VKA.Methods: We evaluated the clinical course of symptomatic deep vein thrombosis (DVT in patients who received the 3-month anticoagulation therapy with fondaparinux/edoxaban (Group A; n=40 in comparison with the findings from our previous experience of patients who received the fondaparinux/VKA combination (Group B; n=33.Results: In both Groups A and B, serum D-dimer was significantly improved after treatment (p<0.001. The thrombus volume assessed by quantitative ultrasound thrombosis (QUT score was significantly reduced in both groups (p<0.001. There was no difference in the proportion of patients who were normalized (ie, disappearance of DVT between the groups, although Group A had significantly more patients who were normalized or improved (ie, disappearance and reduction of DVT (p<0.001. No bleeding event was observed in either group. However, in one patient in Group B, worsening of DVT and development of symptomatic PE were observed.Conclusion: Fondaparinux/edoxaban therapy is as effective as fondaparinux/VKA. This treatment has the possible advantage in thrombus regression. This would be a beneficial therapeutic option for both patients and physicians. Keywords: venous thromboembolism, deep vein thrombosis, anticoagulant therapy, quantitative ultrasound thrombosis score, FXa inhibitors

CFD model of an aerating hydrofoil

International Nuclear Information System (INIS)

Scott, D; Sabourin, M; Beaulieu, S; Papillon, B; Ellis, C

2014-01-01

Improving water quality in the tailrace below hydroelectric dams has become a priority in many river systems. In warm climates, water drawn by the turbine from deep in a reservoir can be deficient in dissolved oxygen (DO), a critical element in maintaining a healthy aquatic ecosystem. Many different solutions have been proposed in order to increase the DO levels in turbine discharge, including: turbine aeration systems (adding air to the water through either the turbine hub, the periphery or through distributed aeration in the runner blades); bubble diffusers in the reservoir or in the tailrace; aerating weirs downstream of the dams; and surface water pumps in the reservoir near the dam. There is a significant potential to increase the effectiveness of these solutions by improving the way that oxygen is introduced into the water; better distributions of bubbles will result in better oxygen transfer. In the present study, a two-phase Computational Fluid Dynamics model has been formulated using a commercial code to study the distribution of air downstream of a simple aerating hydrofoil. The two-phase model uses the Eulerian-Eulerian approach. Appropriate relations are used to model the interphase forces, including the Grace drag force model, the Favre averaged drag force and the Sato enhanced eddy viscosity. The model is validated using experimental results obtained in the water tunnel at the University of Minnesota's Saint Anthony Falls Laboratory. Results are obtained for water velocities between 5 and 10 m/s, air flow rates between 0.5 and 1.5 sL/min and for angles of attack between 0° and -8°. The results of this study show that the CFD model provides a good qualitative comparison to the experimental results by well predicting the wake location at the different flow rates and angles of attack used

Three-year experience with combined treatment with alendronate and alfacalcidol in Japanese patients with severe bone loss and osteoporotic fracture

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Iwamoto J

2011-06-01

Full Text Available Jun Iwamoto1, Yoshihiro Sato2, Mitsuyoshi Uzawa3, Tsuyoshi Takeda1, Hideo Matsumoto11Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Neurology, Mitate Hospital, Fukuoka, Japan; 3Department of Orthopaedic Surgery, Keiyu Orthopaedic Hospital, Gunma, JapanPurpose: Combined treatment with alendronate and alfacalcidol is more useful to increase bone mineral density (BMD than alendronate or alfacalcidol alone. A retrospective study was conducted to investigate the 3-year outcome of combined treatment with alendronate and alfacalcidol in patients with severe bone loss (BMD ≤ 50% of the young adult mean and osteoporotic fracture.Methods: Thirty-four patients (six men and 28 postmenopausal women with primary or secondary osteoporosis who had been treated with alendronate and alfacalcidol for more than 3 years were analyzed. The lumbar spine or total hip BMD and bone turnover markers were monitored, and the incidence of osteoporotic fractures was assessed.Results: The urinary level of cross-linked N-terminal telopeptides of type I collagen and serum level of alkaline phosphatase significantly decreased (-42.5% at 3 months and -18.9% at 3 years, and the lumbar spine BMD, but not the total hip BMD, significantly increased (14.8% at 3 years, compared with the baseline values. However, the incidence of vertebral and nonvertebral fractures was 26.5% and 2.9%, respectively, suggesting a high incidence of vertebral fractures.Conclusion: The results of the present study suggest that combined treatment with alendronate and alfacalcidol may be useful to reduce bone turnover and increase the lumbar spine BMD in patients with severe bone loss and osteoporotic fracture. However, its efficacy against vertebral fractures appears not to be sufficient. Thus, anabolic agents such as teriparatide should be taken into consideration as first-line drugs in patients with severe osteoporosis.Keywords: osteoporosis

Positive Regulation of Staphylococcal Enterotoxin H by Rot (Repressor of Toxin) Protein and Its Importance in Clonal Complex 81 Subtype 1 Lineage-Related Food Poisoning.

Science.gov (United States)

Sato'o, Yusuke; Hisatsune, Junzo; Nagasako, Yuria; Ono, Hisaya K; Omoe, Katsuhiko; Sugai, Motoyuki

2015-11-01

We previously demonstrated the clonal complex 81 (CC81) subtype 1 lineage is the major staphylococcal food poisoning (SFP)-associated lineage in Japan (Y. Sato'o et al., J Clin Microbiol 52:2637-2640, 2014, http://dx.doi.org/10.1128/JCM.00661-14). Strains of this lineage produce staphylococcal enterotoxin H (SEH) in addition to SEA. However, an evaluation of the risk for the recently reported SEH has not been sufficiently conducted. We first searched for staphylococcal enterotoxin (SE) genes and SE proteins in milk samples that caused a large SFP outbreak in Japan. Only SEA and SEH were detected, while there were several SE genes detected in the samples. We next designed an experimental model using a meat product to assess the productivity of SEs and found that only SEA and SEH were detectably produced in situ. Therefore, we investigated the regulation of SEH production using a CC81 subtype 1 isolate. Through mutant analysis of global regulators, we found the repressor of toxin (Rot) functioned oppositely as a stimulator of SEH production. SEA production was not affected by Rot. seh mRNA expression correlated with rot both in media and on the meat product, and the Rot protein was shown to directly bind to the seh promoter. The seh promoter sequence was predicted to form a loop structure and to hide the RNA polymerase binding sequences. We propose Rot binds to the promoter sequence of seh and unfolds the secondary structure that may lead the RNA polymerase to bind the promoter, and then seh mRNA transcription begins. This alternative Rot regulation for SEH may contribute to sufficient toxin production by the CC81 subtype 1 lineage in foods to induce SFP. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Statement at Fukushima Ministerial Conference on Nuclear Safety, 15 December 2012, Koriyama City, Fukushima Prefecture, Japan

International Nuclear Information System (INIS)

Amano, Y.

2012-01-01

When disaster struck at the Fukushima Daiichi Nuclear Power Plant in March 2011, the IAEA offered immediate assistance to the Plant operators and the Japanese authorities as they tried to regain control over the reactors. We began sharing verified information about the accident with the world and helped to channel international assistance to Japan. A high priority was to do everything we could to help ensure the safety of the people of Japan, especially those in Fukushima Prefecture who were most affected by the crisis. I went to Japan a few days after the accident to meet then Prime Minister Kan. I assured him that Japan could count on the support of the entire international community and stressed the need for full transparency. I sent a number of expert teams to assist in areas such as radiological monitoring, food safety, and analysis of the situation at the Fukushima Daiichi Plant. Four IAEA teams undertook measurements in the Fukushima region, both inside and outside the 20 km evacuation zone. An expert on marine monitoring programmes from the IAEA Environmental Laboratories helped to monitor seawater. Joint teams from the IAEA and the UN Food and Agriculture Organization advised local authorities on technical issues related to food safety and agricultural countermeasures. Some important environmental readings at key points in the unfolding crisis were taken by IAEA experts. Our presence helped to provide reassurance to the people of Japan at a very critical time. It is now one year and nine months since the accident. In that time, we have continued to work closely with Japan. Today, I will sign an important document with Governor Sato of Fukushima Prefecture on our cooperation in the coming years. The IAEA will work closely with the Prefecture in radiation monitoring and decontamination. We will also implement human health projects with Fukushima Medical University.

Long-term efficacy and safety of ramosetron in the treatment of diarrhea-predominant irritable bowel syndrome

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Chiba T

2013-07-01

Full Text Available Toshimi Chiba, Kazunari Yamamoto, Shoko Sato, Kazuyuki Suzuki Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan Abstract: Irritable bowel syndrome (IBS is a functional disease with persisting gastrointestinal symptoms that has been classified into four subtypes. Serotonin (5-hydroxytryptamine [5-HT] plays important physiological roles in the contraction and relaxation of smooth muscle. Intraluminal distension of the intestine is known to stimulate the release of endogenous 5-HT from enterochromaffin cells, activating 5-HT3 receptors located on primary afferent neurons and leading to increases in intestinal secretions and peristaltic activity. Ramosetron, a potent and selective 5-HT3-receptor antagonist, has been in development for use in patients suffering from diarrhea-predominant IBS. In a double-blind, placebo-controlled, parallel-group study of 418 patients with diarrhea-predominant IBS-D, once-daily 5 µg and 10 µg doses of ramosetron increased the monthly responder rates of IBS symptoms compared to placebo. In a 12-week randomized controlled trial of 539 patients, a positive response to treatment was reported by 47% of a once-daily 5 µg dose of ramosetron-treated individuals compared to 27% of patients receiving placebo (P<0.001. Furthermore, the responder rate was increased in the oral administration of 5 µg of ramosetron for at least 28 weeks (up to 52 weeks, and long-term efficacy for overall improvement of IBS symptoms was also demonstrated. The rate was further increased subsequently. Adverse events were reported by 7% in ramosetron treatment. No serious adverse events, eg, severe constipation or ischemic colitis, were reported for long-term treatment with ramosetron. In conclusion, further studies to evaluate the long-term efficacy and safety of ramosetron are warranted in the form of randomized controlled trials. Keywords: long

PREFACE: Tenth International Conference on Topics in Astroparticle and Underground Physics (TAUP2007)

Science.gov (United States)

Inoue, Kunio; Suzuki, Atsuto; Mitsui, Tadao

2008-07-01

Otsuka, and Ms Yuri Endo, our workshop secretaries, for their continuous and excellent work in the organization of the conference, and to Ms Chiyo Itoh, and Ms Machiko Mizutani, for their invaluable assistance during the conference. We also gratefully thank the technical staff: Tomoaki Takayama, Hiromitsu Hanada, Takashi Nakajima, for their invaluable help. As announced at the end of the conference, TAUP 2009 will be held in Gran Sasso, Italy, hosted by the Istituto Nazionale di Fisica Nucleare (INFN) with the chair of Professor Eugenio Coccia. Kunio Inoue, Atsuto Suzuki and Tadao Mitsui COMMITTEES TAUP Steering Committee F T Avignone U South Carolina B C Barish CALTECH E Bellotti U Milano/INFN J Bernabéu U Valencia A Bottino (chair) U Torino/INFN V de Alfaro U Torino/INFN T Kajita ICRR U Tokyo C W Kim Johns Hopkins Univ /KIAS E Lorenz U München V Matveev INR Moskow J Morales U Zaragoza D Sinclair U Carleton M Spiro IN2P3 TAUP 2007 International Advisory Committee J J Aubert CNRS Marseille M Baldo-Ceolin U Padova/INFN V Berezinsky INFN-LNGS/INR L Bergström U Stockholm R Bernabei U Roma Tor Vergata/INFN A Bettini U Padova/INFN S Bilenky JINR Dubna D O Caldwell U C Santa Barbara E Coccia INFN-LNGS/U Roma Tor Vergata J Cronin U Chicago A Dar Technion Haifa G Domogatsky INR Moscow H Ejiri U Osaka J Ellis CERN E Fernández IFAE Barcelona E Fiorini U Milano/INFN G Fogli U Bari/INFN T Gaisser U Delaware G Gelmini UCLA G Gerbier CEA Saclay F Halzen U Wisconsin W Haxton U Washington T Kirsten MPI Heidelberg L Maiani U Roma/INFN A McDonald Queen's U K Nakamura KEK E Peterson U Minneapolis R Petronzio INFN/U Roma Tor Vergata G Raffelt MPI München R Rebolo IAC Tenerife L Resvanis U Athens P Salati U Savoie/LAPTH Annecy A Smirnov ICTP Trieste N Spooner U Sheffield S Ting MIT/CERN Y Totsuka U Tokyo M S Turner FNAL/U Chicago J W F Valle IFIC Valencia D Vignaud APC Paris F von Feilitzsch T U München G Zatsepin INR Moscow TAUP 2007 Organizing Committee A Bottino U Torino/INFN D

Comparative effectiveness of switching paroxetine formulation for treatment of major depressive disorder: an open-label multicenter study

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Otsubo T

2018-04-01

Full Text Available Tempei Otsubo,1 Yoshinori Watanabe,2,3 Seiji Hongo,3 Mikichika Inoue,4 Kimiko Akimoto,4 Ken Murakami,5 Ryutaro Takahashi,6 Toshiaki Kikuchi7 1Department of Psychiatry, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan; 2Himorogi Psychiatric Institute, Tokyo, Japan; 3Nanko Clinic of Psychiatry, Shirakawa, Japan; 4Ikebukuro Internal Medicine, Tokyo, Japan; 5Murakami Hospital, Tokyo, Japan; 6Takahashi Clinic, Tokyo, Japan; 7Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan Aim: To assess the effectiveness and safety of switching the antidepressant formulation from immediate-release (IR to controlled-release (CR paroxetine in patients with major depressive disorder (MDD. Patients and methods: A total of 113 outpatients with MDD diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, and treated with a stable dose of IR paroxetine for at least 6 months were enrolled. Patients were then switched to CR paroxetine for 8 weeks. Effectiveness was evaluated by scores on the Himorogi Self-Rating Depression/Anxiety Scales (HSDS/HSAS and the Clinical Global Impression – Severity (CGI-S. Safety was evaluated based on the reported adverse drug reactions (ADRs. Medication satisfaction and preference were assessed based on questionnaire responses using Likert-type scales. Results: The overall patient HSDS/HSAS scores significantly improved after switching from IR to CR paroxetine (P<0.001. Furthermore, CR paroxetine was superior to IR paroxetine (P<0.001 according to the results of the CGI-S evaluation. ADRs were experienced by 14 (12.4% patients, including dry mouth, nausea/vomiting, somnolence/drowsiness, and wakefulness/arousal during sleep. Satisfaction and preference for paroxetine improved after switching to the CR formulation (P<0.001; chi-square test. Conclusion: These results suggest that switching the treatment from IR to CR paroxetine could

Envisioning the Shôjo Aesthetic in Illustrations of Miyazawa Kenji’s Literature.

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Helen Claire Kilpatrick

2013-01-01

emerging audiences in Japan. + + + This essay won the 2013 Inoue Yasushi Award for the best article or book chapter on Japanese literature published in Australia or New Zealand.

The association between suicide risk and self-esteem in Japanese university students with major depressive episodes of major depressive disorder

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Mitsui N

2014-05-01

Full Text Available Nobuyuki Mitsui,1 Satoshi Asakura,1,2 Yusuke Shimizu,1 Yutaka Fujii,1 Atsuhito Toyomaki,1 Yuki Kako,1 Teruaki Tanaka,1 Nobuki Kitagawa,3 Takeshi Inoue,1 Ichiro Kusumi1 1Department of Psychiatry, Hokkaido University Graduate School of Medicine, 2Health care center of Hokkaido University, Kita-ku, Sapporo, 3Department of Clinical Social Work, Health Sciences University of Hokkaido School of Nursing and Social Services, Tobetsu, Ishikari, Japan Background: The suicide risk among young adults is related to multiple factors; therefore, it is difficult to predict and prevent suicidal behavior. Aim: We conducted the present study to reveal the most important factors relating to suicidal ideation in Japanese university students with major depressive episodes (MDEs of major depressive disorder (MDD. Methods: The subjects were 30 Japanese university students who had MDEs of MDD, and were aged between 18 and 26 years old. They were divided into two groups – without suicide risk group (n=15, and with suicide risk group (n=15 – based on the results of the Mini-International Neuropsychiatric Interview. Additionally, healthy controls were recruited from the same population (n=15. All subjects completed the self-assessment scales including the Beck Depression Inventory 2nd edition (BDI-II, the Beck Hopelessness Scale (BHS, Rosenberg's Self-Esteem Scale (RSES, and SF-36v2TM (The Medical Outcomes Study 36-item short-form health survey version 2, and they were all administered a battery of neuropsychological tests. Results: The RSES score of the suicide risk group was significantly lower than the RSES score of the without suicide risk group, whereas the BDI-II score and the BHS score were not significantly different between the two groups. The mean social functioning score on the SF-36v2 of the with suicide risk group was significantly lower than that of the without suicide risk group. Conclusion: The individual's self-esteem and social functioning may play an

Visual acuity loss associated with excessive “dry macula” in exudative age-related macular degeneration

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Takahashi H

2018-02-01

Full Text Available Hidenori Takahashi,1–3 Yuji Inoue,1,2 Xue Tan,2,3 Satoru Inoda,1 Shinichi Sakamoto,1 Yusuke Arai,1 Yasuo Yanagi,4–6 Yujiro Fujino,2,3 Hidetoshi Kawashima1 1Department of Ophthalmology, Jichi Medical University, Shimotsuke, 2Department of Ophthalmology, The University of Tokyo, Bunkyo, 3Department of Ophthalmology, Japan Community Health Care Organization Tokyo Shinjuku Medical Center, Shinjuku, Japan; 4Medical Retina, Singapore National Eye Centre, 5Medical Retina, Singapore Eye Research Institute, 6Eye-ACP, Duke NUS Medical School, National University of Singapore, Singapore Purpose: To investigate the correlation between visual acuity and central macular thickness (CMT and choroidal thickness (CCT in patients with wet age-related macular degeneration (AMD. Methods: In this retrospective analysis, 14 eyes that received >10 ranibizumab injections (based on pro re nata [PRN] regimen and maintained initial visual acuity gain were analyzed. The following 5 parameters were measured at the foveal center: CMT (distance from the inner limiting membrane [ILM] to Bruch’s membrane; central retinal thickness (CRT; distance from the ILM to the inner limit of the retinal pigment epithelium or subretinal fluid [SRF]; SRF thickness (SRFT; pigment epithelium detachment thickness (PEDT; and CCT. The correlation between the logarithm of the minimum angle of resolution (logMAR best-corrected visual acuity (BCVA and the 5 parameters was examined with generalized estimating equations. Results: CMT, CRT, and CCT were negatively correlated with logMAR BCVA (P=0.031, 0.023, and 0.036, respectively when only CMT values less than the thickness that maximized visual acuity for each eye were used for the analysis. Each 100-µm reduction in CMT, CRT, or CCT improved logMAR BCVA by -0.1, -0.08, or -0.07, respectively. SRFT and PEDT were not correlated with BCVA. The median CMT that maximized the visual acuity was 230 µm. Conclusion: Dry macula with CMT <230 µm was

Relationship of airflow limitation severity with work productivity reduction and sick leave in a Japanese working population

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Onoue A

2016-03-01

Full Text Available Ayumi Onoue,1 Hisamitsu Omori,1 Takahiko Katoh,2 Kenichi Kubota,3 Yoshio Nonami,3 Yasuhiro Ogata,3 Hiromasa Inoue4 1Department of Biomedical Laboratory Sciences, 2Department of Public Health, Faculty of Life Sciences, Kumamoto University, 3Japanese Red Cross Kumamoto Health Care Center, Kumamoto, 4Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan Background: The aim of this study was to reveal the association between airflow limitation (AL severity and reduction with work productivity as well as use of sick leave among Japanese workers.Methods: This cross-sectional study included 1,378 workers who underwent a lung function test during a health checkup at the Japanese Red Cross Kumamoto Health Care Center. AL was defined as forced expiratory volume in 1 second/forced vital capacity of <0.7. Workers completed a questionnaire on productivity loss at work and sick leave. The quality and quantity of productivity loss at work were measured on a ten-point scale indicating how much work was actually performed on the previous workday. Participants were asked how many days in the past 12 months they were unable to work because of health problems. Logistic regression analysis was used to assess the associations between AL severity and the quality and quantity of productivity loss at work as well as use of sick leave.Results: Compared with workers without AL, workers with moderate-to-severe AL showed a significant productivity loss (quality: odds ratio [OR] =2.04, 95% confidence interval [CI]: 1.12–3.71, P=0.02 and quantity: OR =2.19, 95% CI: 1.20–4.00, P=0.011 and use of sick leave (OR =2.69, 95% CI: 1.33–5.44, P=0.006 after adjusting for sex, age, body mass index, smoking status, hypertension, hyperglycemia, dyslipidemia, sleep duration, work hours per day, and workplace smoking environment.Conclusion: AL severity was significantly associated with work productivity loss and use

Clinical course of thyroid function and thyroid associated-ophthalmopathy in patients with euthyroid Graves’ disease

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Suzuki N

2018-04-01

Full Text Available Nami Suzuki,1 Jaeduk Yoshimura Noh,1 Toshiaki Kameda,1 Ai Yoshihara,1 Hidemi Ohye,1 Miho Suzuki,1 Masako Matsumoto,1 Yo Kunii,1 Kenji Iwaku,1 Natsuko Watanabe,1 Koji Mukasa,1 Ai Kozaki,2 Toshu Inoue,2 Kiminori Sugino,1 Koichi Ito1 1Department of Internal Medicine, Ito Hospital, Tokyo, Japan; 2Department of Ophthalmology, Olympia Eye Hospital, Tokyo, Japan Background: Euthyroid Graves’ disease (EGD is a rare condition defined as the presence of thyroid-associated ophthalmopathy (TAO in patients with normal thyroid function. Due to the rarity of this disease, only a limited number of studies and case reports are available for further evaluation of the characteristics of the disease. The aim of this study was to examine the changes in the thyroid function, thyrotropin receptor antibodies (TRAb and eye symptoms, and then determine whether TRAb is related to TAO in EGD patients. TRAb in this study was defined as including both thyrotropin-binding inhibitory immunoglobulin (TBII and thyroid-stimulating immunoglobulin (TSAb. Patients and methods: Medical records of patients diagnosed with EGD were reviewed. Ophthalmologists specializing in TAO examined the eyes of all subjects. Results: Of the 58 patients diagnosed with EGD, 24.1% developed hyperthyroidism, while 3.4% developed hypothyroidism. A total of 72.4% of the 58 patients remained euthyroid throughout the entire follow-up period. At the initial presentation, TBII and TSAb were positive in 74.5% and 70.5%, respectively. Ophthalmic treatments were administered to 30 (51.7% out of the 58 patients. A significant spontaneous improvement of the eye symptoms was found in 28 of the EGD patients who did not require eye treatments. EGD patients exhibited positive rates for both TBII and TSAb, with the number of the TRAb-positive patients gradually decreasing while the eye symptoms spontaneously improved over time. There were no correlations found between TRAb at initial presentation and the eye symptoms

A Promising Tool in Retina Regeneration: Current Perspectives and Challenges When Using Mesenchymal Progenitor Stem Cells in Veterinary and Human Ophthalmological Applications.

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Cislo-Pakuluk, Anna; Marycz, Krzysztof

2017-10-01

Visual impairment is a common ailment of the current world population, with more exposure to CCD screens and fluorescent lighting, approximately 285 billion people suffer from this deficiency and 13% of those are considered clinically blind. More common causes for visual impairment include age-related macular degeneration (AMD), glaucoma and diabetic retinopathy (Zhu et al. Molecular Medicine Reports, 2015; Kolb et al. 2007; Machalińska et al. Current Eye Research, 34(9),748-760, 2009) among a few. As cases of retinal and optic nerve diseases rise, it is vital to find a treatment, which has led to investigation of the therapeutic potential of various stem cells types (Bull et al. Investigative Opthalmology & Visual Science, 50(9), 4244, 2009; Bull et al. Investigative Opthalmology & Visual Science, 49(8), 3449, 2008; Yu et al. Biochemical and Biophysical Research Communications, 344(4), 1071-1079, 2006; Na et al. Graefe's Archive for Clinical and Experimental Ophthalmology, 247(4), 503-514, 2008). In previous studies, some of the stem cell variants used include human Muller SCs and bone marrow derived SCs. Some of the regenerative potential characteristics of mesenchymal progenitor stem cells (MSCs) include their multilineage differentiation potential, their immunomodulatory effects, their high proliferative activity, they can be easily cultured in vitro, and finally their potential to synthesize and secrete membrane derived vesicles rich in growth factors, mRNA and miRNA which possibly aid in regulation of tissue damage regeneration. These facts alone, explain why MSCs are so widely used in clinical trials, 350 up to date (Switonski, Reproductive Biology, 14(1), 44-50, 2014). Animal studies have demonstrated that sub-retinal transplantation of MSCs delays retinal degeneration and preserves retinal function through trophic response (Inoue et al. Experimental Eye Research, 85(2), 234-241, 2007). Umbilical cord derived MSCs (UC/MSCs) have also been shown to contain

Synchrotron FT-IR analyses of microstructured biomineral domains: Hints to the biomineralization processes in freshwater cultured pearls.

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Soldati, A. L.; Vicente-Vilas, V.; Gasharova, B.; Jacob, D. E.

2009-04-01

to identify and pre-select those pearls containing ACC. Infrared absorption spectra were measured using a Ge ATR objective on 100-200 ?m thin sections and polished pearl sections. Attenuated total reflectance spectroscopy gives the opportunity to measure the infrared absorption in a reflectance mode directly without necessity to apply Kramers-Kronig transformation. The spectral range available is 650-5000 cm-1when using a Ge ATR crystal with the MCT detector at the ANKA-IR microscope and allowed the detection of the ?4 in-plane bending band (around 750 cm-1 in vaterite and 710 cm-1 in aragonite), the ?1 symmetric stretching bands (1070-7085 cm-1 for vaterite4 and 1082-1084 cm-1 in aragonite5), the ?2 out-of-plane bending vibration of the CO3 groups (855 cm-1 for vaterite and 857-877 cm-1 in aragonite) and the ?3 asymmetric stretching (1420-1490 cm-1 in vaterite and 1480 cm-1 in aragonite) respectively (Sato and Masuda, 1969; Yamoto et al., 1974).Water was detected by the presence of the O-H stretching at around 3500 cm-1. Proteins and sugars included in the biogenic carbonates were recognized through the N-H and C-H bands, for example 1717-1575 cm-1 for aspartic acid, 1712-1558 cm-1 for glutamic acid, 1500 to 2000 cm-1 amide I and II (Dauphin et al., 2006). References WEHRMEISTER U., JACOB D.E., SOLDATI A.L., HÄGER T. & HOFMEISTER W. 2007. Vaterite in freshwater cultured pearls from China and Japan. The Journal of Gemmology; 31: 269-276. SOLDATI A.L., JACOB D.E., WEHRMEISTER U.& HOFMEISTER W. 2008. Structural characterization and chemical composition of aragonite and vaterite in freshwater cultured pearls. Mineralogical Magazine 72: 577-590. JACOB, D.E., SOLDATI, A.L., WIRTH, R., HUTH, J., WEHRMEISTER, U. & HOFMEISTER, W. 2008. Nanostructure, composition and mechanisms of bivalve shell growth. Geochimica et Coscmochimica Acta 72: 5401-5415. SATO M. & MATSUDA S. 1969. Structure of vaterite and infrared spectra. Z. Kistalography 129: 405-410. YAMAMOTO A, SHIRO Y

Tremendous Mass Concentration in Strange Galaxy Revealed by VLBA

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1995-01-01

National Radio Astronomy Observatory in Socorro, NM; and Makoto Inoue, also of Nobeyama, presented their discovery today to the 185th meeting of the American Astronomical Society in Tucson, Arizona. "The beautiful definition of the motion in the disk and its structure, and the high density of the central object -- at least ten thousand times that of any known star cluster -- convinces us that this must be a black hole.'' says James Moran. "The dynamics of the disk are fairly simple, and we suspect it may offer us a laboratory for measuring a host of other fundamental phenomena in astrophysics.'' Miller Goss, assistant director of NRAO for VLBA/ VLA Operations comments, ''this is a sensational result, showing the excellent science that comes from skilled use of the highest- resolution instrument available to astronomers... It's particularly nice to see such valuable contributions coming from the early use of the VLBA." The team of astronomers used the VLBA to study a disk of molecules deep within the nucleus of NGC 4258. The disk, tiny compared to the galaxy, contains heated water molecules that amplify microwave radio emissions in a manner similar to the way in which a laser amplifies light. The disk is oriented fortuitously so that pencil-like beams of microwaves are directed toward the earth. These powerful naturally-occurring microwave amplifiers, called masers, were discovered in the galaxy in 1982. In 1992 Nakai, Inoue and Miyoshi, using a radio telescope at Nobeyama, Japan, made the surprising discovery that some of the masers had very high velocities with respect to the galaxy. The large apparent velocities they observed could not be accounted for by the galaxy's normal rotation. At that time, the Japanese researchers suggested that the masers might be orbiting a black hole. Research by Greenhill and colleagues, using the technique of Very Long Baseline Interferometry (VLBI), provided preliminary support for this hypothesis. The VLBA, an instrument built

Método simplificado para el diagnóstico del síndrome de apnea-hipopnea del sueño (SAHS: A propósito de una serie de casos empleando el polígrafo respiratorio BREAS SC-20.

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Jorge Rey de Castro Mujica

2007-04-01

Full Text Available Objetivo: Presentar una serie de casos con diagnóstico de síndrome apnea hipopnea del Sueño (SAHS establecido con un polígrafo respiratorio (PR. Materiales y métodos: Se presentan 53 PRs realizadas entre enero 2005 y octubre 2006 en pacientes con sospecha de trastornos respiratorios del sueño. Se utilizó el polígrafo respiratorio BREAS SC-20 validado por nosotros anteriormente. La prueba fue implementada a lo largo de la noche en el domicilio del paciente y sin supervisión de personal técnico. En 32 (60% casos la PR fue instalada en el consultorio y el resto en el domicilio del paciente. Resultados: Se analizaron 53 PRs, realizadas en el mismo número de pacientes. El equipo falló en seis (11% ocasiones; las seis pruebas fueron repetidas obteniéndose buenos resultados para el análisis. El Tiempo de registro fue 7,7±1,1 [5,5-10,7] horas, índice de apnea-hipopnea 35,5±20 [0-82], tiempo porcentual de registro con SatO2Hb menor de 90% (T90 9,8±15,2 [0-62] % y desaturación máxima de oxígeno (DesMax 73±14,8 [38-91] %. Los principales diagnósticos fueron: SAHS 46 (86%, apnea central con patrón periódico Cheyne Stokes 3 (6%, ronquido primario benigno 2 (4% y prueba normal 2 (4%. El procedimiento fue bien tolerado y no hubo efectos secundarios relacionados. Conclusiones: Con los resultados obtenidos, consideramos que el sistema BREAS SC-20 bajo supervisión de médicos entrenados en los trastornos respiratorios del sueño; es una herramienta útil, práctica y económica para el diagnóstico del SAHS.(Rev Med Hered 2007;18:59-67.

H(D) → D(H) + Cu(111) collision system: molecular dynamics study of surface temperature effects.

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Vurdu, Can D; Güvenç, Ziya B

2011-04-28

All the channels of the reaction dynamics of gas-phase H (or D) atoms with D (or H) atoms adsorbed onto a Cu(111) surface have been studied by quasiclassical constant energy molecular dynamics simulations. The surface is flexible and is prepared at different temperature values, such as 30 K, 94 K, and 160 K. The adsorbates were distributed randomly on the surface to create 0.18 ML, 0.28 ML, and 0.50 ML of coverages. The multi-layer slab is mimicked by a many-body embedded-atom potential energy function. The slab atoms can move according to the exerted external forces. Treating the slab atoms non-rigid has an important effect on the dynamics of the projectile atom and adsorbates. Significant energy transfer from the projectile atom to the surface lattice atoms takes place especially during the first impact that modifies significantly the details of the dynamics of the collisions. Effects of the different temperatures of the slab are investigated in this study. Interaction between the surface atoms and the adsorbates is modeled by a modified London-Eyring-Polanyi-Sato (LEPS) function. The LEPS parameters are determined by using the total energy values which were calculated by a density functional theory and a generalized gradient approximation for an exchange-correlation energy for many different orientations, and locations of one- and two-hydrogen atoms on the Cu(111) surface. The rms value of the fitting procedure is about 0.16 eV. Many different channels of the processes on the surface have been examined, such as inelastic reflection of the incident hydrogen, subsurface penetration of the incident projectile and adsorbates, sticking of the incident atom on the surface. In addition, hot-atom and Eley-Rideal direct processes are investigated. The hot-atom process is found to be more significant than the Eley-Rideal process. Furthermore, the rate of subsurface penetration is larger than the sticking rate on the surface. In addition, these results are compared and

1.6 μm DIAL Measurement and Back Trajectory Analysis of CO2 Concentration Profiles in the Lower-Atmosphere

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Shibata, Y.; Nagasawa, C.; Abo, M.

2016-12-01

Carbon dioxide (CO2) is the primary greenhouse gas emitted through human activities. In addition to the ground level CO2 network, vertical CO2 concentration profiles also play an important role for the estimation of the carbon budget and global warming in the inversion method. Especially, for the detailed analysis of forest carbon dynamics and CO2 fluxes of urban area, vertical CO2 concentration profiles with high spatial and temporal resolution in the lower atmosphere have been conducted by a differential absorption lidar (DIAL). We have observed several vertical profiles of CO2 concentrations for nighttime and daytime from 0.25 to 2.5 km altitude with range resolution of 300 m and integration time of 1 hour. In order to extract information on the origin of the CO2 masses, one day back trajectories were calculated by using a three dimensional (3-D) atmospheric transport model. In many cases, CO2 low concentration layers of over 1.5km altitude were flown by westerly winds from the forest. In another case, high concentration layers of CO2 were flown from the urban areas. As the spectra of absorption lines of any molecules are influenced basically by the temperature in the atmosphere, laser beams of three wavelengths around a CO2 absorption spectrum are transmitted alternately to the atmosphere for simultaneous measurements of CO2 concentration and temperature profiles. Moreover, a few processing algorithms of CO2-DIAL are also performed for improvement of measurement accuracy. For computation of trajectories and drawing their figures, the JRA-25 data provided by the cooperative research project for the JRA-25 long-term reanalysis of the Japan Meteorological Agency (JMA) and the Central Research Institute of Electric Power Industry (CRIEPI) and the NIPR trajectory model (Tomikawa and Sato, 2005; http://firp-nitram.nipr.ac.jp) were used. This work was financially supported by the System Development Program for Advanced Measurement and Analysis of the Japan Science and

Neural basis of three dimensions of agitated behaviors in patients with Alzheimer disease

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Banno K

2014-02-01

Full Text Available Koichi Banno,1 Shutaro Nakaaki,2 Junko Sato,1 Katsuyoshi Torii,1 Jin Narumoto,3 Jun Miyata,4 Nobutsugu Hirono,5 Toshi A Furukawa,6 Masaru Mimura,2 Tatsuo Akechi1 1Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; 2Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 3Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 4Department of Neuropsychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 5Department of Psychology, Kobe Gakuin University; Hyogo, Japan; 6Departments of Health Promotion and Human Behavior and of Clinical Epidemiology, Graduate School of Medicine/School of Public Health, Kyoto University, Kyoto, Japan Background: Agitated behaviors are frequently observed in patients with Alzheimer disease (AD. The neural substrate underlying the agitated behaviors in dementia is unclear. We hypothesized that different dimensions of agitated behaviors are mediated by distinct neural systems. Methods: All the patients (n=32 underwent single photon emission computed tomography (SPECT. Using the Agitated Behavior in Dementia scale, we identified the relationships between regional cerebral blood flow (rCBF patterns and the presence of each of three dimensions of agitated behavior (physically agitated behavior, verbally agitated behavior, and psychosis symptoms in AD patients. Statistical parametric mapping (SPM software was used to explore these neural correlations. Results: Physically agitated behavior was significantly correlated with lower rCBF values in the right superior temporal gyrus (Brodmann 22 and the right inferior frontal gyrus (Brodmann 47. Verbally agitated behavior was significantly associated with lower rCBF values in the left inferior frontal gyrus (Brodmann 46, 44 and the left insula (Brodmann 13. The psychosis symptoms were significantly correlated

Bilateral endogenous Candida albicans subretinal abscess with suspected mixed bacterial infection

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Arai Y

2014-10-01

Full Text Available Yusuke Arai,1 Yukihiro Sato,1 Atsushi Yoshida,1 Hidetoshi Kawashima,1 Toshikatsu Kaburaki,2 Harumi Gomi3 1Department of Ophthalmology, Jichi Medical University, Tochigi, Japan; 2Department of Ophthalmology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan; 3Center for Clinical Infectious Diseases, Jichi Medical University, Tochigi, Japan Purpose: Candida albicans subretinal abscess is extremely rare. To our knowledge, only one unilateral case has been reported. Herein, we report one bilateral case. Mixed bacterial infection was also suspected based on broad-range real-time polymerase chain reaction.Methods: A 64-year-old man being treated with oral corticosteroids for interstitial pneumonia visited us for visual loss in the left eye. Best corrected visual acuity (BCVA was 20/20 in the right eye and 8/200 in the left eye. Funduscopy revealed round yellowish-white subretinal lesions with retinal hemorrhage in both eyes.Results: Broad-range polymerase chain reaction of the vitreous fluid from the left eye showed a high copy count of bacterial 16s ribosome RNA. Despite large doses of antibiotics, the abscess expanded and vision decreased to light perception in the left eye. Exenteration of the left eye was performed followed by microscopic examination showing Gram-negative bacilli, and C. albicans was also cultured. Antibiotics and the maximum doses of antifungal drugs were administered. However, the abscess in the right eye expanded, and BCVA decreased to 2/200. Vitrectomy and silicone oil tamponade were performed. Vitreous fluid culture revealed C. albicans. At 16 months follow-up, BCVA was stable at 4/200 with healing of the subretinal abscess under silicone oil.Conclusion: Since C. albicans subretinal abscess is extremely rare and there was a concurrent mixed bacterial infection, diagnostic procedures in our bilateral case were more complicated than usual. C. albicans infection should be included in the differential diagnosis

[Effects of intravenous alimentation on adjuvant chemotherapy--an experimental study on the distribution of 5-FU after injection of tegafur (2)].

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Kimoto, M; Nagano, H; Sano, K

1987-10-01

The stomach, small and large intestines, heart, lungs, bone and kidneys were removed from 48 Sato lung cancer-bearing rats used in the previous experiments and given 90 mg/kg of tegafur (FT-207) by single intravenous administration and tissue 5-FU and FT-207 concentrations were measured. FT-207 concentration in the alimentary canal was somewhat lower than the blood concentration, but both were lowered in parallel. 5-FU concentration in the stomach and large intestines showed virtually identical changes in both IVH and PO groups, but IVH group tended to have higher concentration. IVH group showed higher values than PO group anytime, particularly in the large intestines. A reduction of the side effects on the digestive system via intravenous alimentation was thought due to the elimination of mechanical stimulation via a cessation of oral feeding. 5-FU concentration in the bone was highest in PO group at six hours after administration and blood concentration changes were parallel, but there was virtually no change in IVH group. Maximum values were found one hour after administration and slowly declined thereafter; at 24 hrs the values were 0.059 +/- 0.013 microgram/g, relatively high compared to the PO group at 0.041 +/- 0.022 microgram/g. In the present study under intravenous alimentation, the concentration changes were slight in spite of 5-FU maximum concentration being lower than that by oral feeding and the long-term high concentration which was maintained; this is thought to be a disadvantageous action with regard to the bone marrow. FT-207 concentration in the kidney, heart and lungs was the same as that for the blood, with a gradual reduction in IVH group. 5-FU concentration was the same for the kidneys and IVH group quickly reached to the high levels compared to PO group with only slight changes thereafter. Effects of continuous water load might be involved but not clear.

Observational longitudinal study of symptom burden and time for recovery from community-acquired pneumonia reported by older adults surveyed nationwide using the CAP Burden of Illness Questionnaire

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Wyrwich KW

2015-07-01

Full Text Available Kathleen W Wyrwich,1 Holly Yu,2 Reiko Sato,2 John H Powers31Evidera, Inc., Bethesda, MD, USA; 2Pfizer Inc., Collegeville, PA, USA; 3George Washington University School of Medicine and Health Sciences, Washington, DC, USABackground: Millions of older adults who develop community-acquired pneumonia (CAP each year survive, but there is a large knowledge gap on the burden of CAP and the recovery process in survivors from the patient perspective.Methods: The newly developed CAP Burden of Illness Questionnaire was administered through a Web survey to a nationwide sample of US adults aged ≥50 years who were recently diagnosed with CAP. Survey respondents with unresolved symptoms or other CAP-related health problems completed a second survey 30 days later; a third survey was completed another 30 days later by respondents with unresolved symptoms or problems. Nationally representative results describing the average time to recovery of symptoms and other CAP-related problems were achieved using post-stratification weights.Results: Five hundred participants completed the initial survey. The time to resolution for the CAP symptoms of weakness, shortness of breath, and tiredness exceeded 3 weeks on average. There was an average of 13 days of absenteeism, and 3 weeks (mean =21 days before achieving full work/activity productivity after CAP. For participants with health conditions that worsened from pneumonia, chronic emphysema and chronic obstructive pulmonary disease took the longest to return to baseline (mean =60 and 52.4 days, respectively.Conclusion: The results from this study demonstrate that older adults surviving a CAP episode experience a significant multi-symptom illness with long recovery periods to achieve pre-CAP health and productivity. These findings highlight the need for further research on effective clinician–patient communication, the need for patient-centered outcomes in clinical trials for CAP therapeutics, adequate home care during

A new MRI land surface model HAL

Science.gov (United States)

Hosaka, M.

2011-12-01

A land surface model HAL is newly developed for MRI-ESM1. It is used for the CMIP simulations. HAL consists of three submodels: SiByl (vegetation), SNOWA (snow) and SOILA (soil) in the current version. It also contains a land coupler LCUP which connects some submodels and an atmospheric model. The vegetation submodel SiByl has surface vegetation processes similar to JMA/SiB (Sato et al. 1987, Hirai et al. 2007). SiByl has 2 vegetation layers (canopy and grass) and calculates heat, moisture, and momentum fluxes between the land surface and the atmosphere. The snow submodel SNOWA can have any number of snow layers and the maximum value is set to 8 for the CMIP5 experiments. Temperature, SWE, density, grain size and the aerosol deposition contents of each layer are predicted. The snow properties including the grain size are predicted due to snow metamorphism processes (Niwano et al., 2011), and the snow albedo is diagnosed from the aerosol mixing ratio, the snow properties and the temperature (Aoki et al., 2011). The soil submodel SOILA can also have any number of soil layers, and is composed of 14 soil layers in the CMIP5 experiments. The temperature of each layer is predicted by solving heat conduction equations. The soil moisture is predicted by solving the Darcy equation, in which hydraulic conductivity depends on the soil moisture. The land coupler LCUP is designed to enable the complicated constructions of the submidels. HAL can include some competing submodels (precise and detailed ones, and simpler ones), and they can run at the same simulations. LCUP enables a 2-step model validation, in which we compare the results of the detailed submodels with the in-situ observation directly at the 1st step, and follows the comparison between them and those of the simpler ones at the 2nd step. When the performances of the detailed ones are good, we can improve the simpler ones by using the detailed ones as reference models.

Correlation and Role of Nitric Oxide (NO) and BCL-2 in Duchenne Muscular Dystrophy (DMD) Patients

International Nuclear Information System (INIS)

Moawed, F.S.M.

2009-01-01

The dystrophin protein is located beneath the cell membrane (sarcolemma) of the muscle cell (myofiber) and serves to link the contractile machinery (sarcomere) and associated cytoskeleton to the extracellular matrix where collagens transmit the muscle force (Grounds, 2008). Absent or defective dystrophin results in myofiber fragility leading to breakdown (necrosis) that is repeated over time until formation of new muscle (regeneration) fails and the amaged skeletal muscle is replaced by fibrous or fatty connective tissue (Cyrulnik and Hinton, 2008; Matsumura et al., 2009). Skeletal muscle is capable of complete regeneration due to stem cells that reside in skeletal muscle and non-muscle (circulating) stem cell populations (Narciso et al., 2007). However, in severe myopathic diseases such as DMD, this regenerative capacity is exhausted (Shi and Garry, 2006). This exhaustion could be explained by two plausible theories: oxidative stress (Sato et al., 2008) and replicative aging, that lead to increased rate of myofiber death (Abdel et al., 2007). If a physician suspects DMD after examining the boy, he will use the creatine phosphokinase (CPK) test to determine Introduction xiv if the muscles are damaged. This test measures the amount of CPK in the blood. In DMD patients, CPK leaks out of the muscle cell into the bloodstream, so a high level (nearly 50 to 100 times more) confirms that there is muscle damage (Burdi et al., 2009). During the 1990s and through the early years of the 21st century, many promising, sophisticated genetic techniques have been designed to ameliorate the devastating impact of muscular dystrophy on the structure and function of skeletal muscles. There is no known cure for Duchenne muscular dystrophy, although recent stem-cell research is showing promising vectors that may replace damaged muscle tissue (Faulkner et al., 2008). Meanwhile, the use of low energy laser irradiation, is a promising means to enhance both the survival and functionality of

Behavior management approach for agitated behavior in Japanese patients with dementia: a pilot study

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Sato J

2012-12-01

Full Text Available Junko Sato,1 Shutaro Nakaaki,2 Katsuyoshi Torii,1 Mizuki Oka,2 Atsushi Negi,1 Hiroshi Tatsumi,3 Jin Narumoto,4 Toshi A Furukawa,5 Masaru Mimura21Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, 2Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 3Department of Health Science, Faculty of Psychological and Physical Science, Aichi Gakuin University, Nagoya, 4Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 5Department of Health Promotion and Human Behavior (Cognitive-Behavioral Medicine, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, JapanBackground: Agitated behaviors are frequently observed in patients with dementia and can cause severe distress to caregivers. However, little evidence of the efficacy of nonpharmacological interventions for agitated behaviors exists for patients with dementia. The present pilot study aimed to evaluate a behavioral management program developed by the Seattle Protocols for patients with agitated behaviors in Japan.Methods: Eighteen patients with dementia (Alzheimer’s disease, n = 14; dementia with Lewy bodies, n = 4 participated in an open study testing the effectiveness of a behavioral management program. The intervention consisted of 20 sessions over the course of 3 months. The primary outcomes were severity of agitation in dementia, as measured using the Agitated Behavior in Dementia scale (ABID and the Cohen-Mansfield Agitation Inventory (CMAI.Results: The behavioral management program resulted in significant reductions in total scores on both the ABID and CMAI. Although both physically agitated and verbally agitated behavior scores on the ABID improved significantly, symptoms of psychosis did not improve after the intervention.Conclusion: The behavioral management technique may be beneficial to distressed caregivers of

Comparison of Different Recruitment Methods for Sexual and Reproductive Health Research: Social Media-Based Versus Conventional Methods.

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Motoki, Yoko; Miyagi, Etsuko; Taguri, Masataka; Asai-Sato, Mikiko; Enomoto, Takayuki; Wark, John Dennis; Garland, Suzanne Marie

2017-03-10

Prior research about the sexual and reproductive health of young women has relied mostly on self-reported survey studies. Thus, participant recruitment using Web-based methods can improve sexual and reproductive health research about cervical cancer prevention. In our prior study, we reported that Facebook is a promising way to reach young women for sexual and reproductive health research. However, it remains unknown whether Web-based or other conventional recruitment methods (ie, face-to-face or flyer distribution) yield comparable survey responses from similar participants. We conducted a survey to determine whether there was a difference in the sexual and reproductive health survey responses of young Japanese women based on recruitment methods: social media-based and conventional methods. From July 2012 to March 2013 (9 months), we invited women of ages 16-35 years in Kanagawa, Japan, to complete a Web-based questionnaire. They were recruited through either a social media-based (social networking site, SNS, group) or by conventional methods (conventional group). All participants enrolled were required to fill out and submit their responses through a Web-based questionnaire about their sexual and reproductive health for cervical cancer prevention. Of the 243 participants, 52.3% (127/243) were recruited by SNS, whereas 47.7% (116/243) were recruited by conventional methods. We found no differences between recruitment methods in responses to behaviors and attitudes to sexual and reproductive health survey, although more participants from the conventional group (15%, 14/95) chose not to answer the age of first intercourse compared with those from the SNS group (5.2%, 6/116; P=.03). No differences were found between recruitment methods in the responses of young Japanese women to a Web-based sexual and reproductive health survey. ©Yoko Motoki, Etsuko Miyagi, Masataka Taguri, Mikiko Asai-Sato, Takayuki Enomoto, John Dennis Wark, Suzanne Marie Garland. Originally

Interface tracking computations of bubble dynamics in nucleate flow boiling

International Nuclear Information System (INIS)

Giustini, G.

2015-01-01

The boiling process is of utter importance for the design and operation of water-cooled nuclear reactors. Despite continuous effort over the past decades, a fully mechanistic model of boiling in the presence of a solid surface has not yet been achieved. Uncertainties exist at fundamental level, since the microscopic phenomena governing nucleate boiling are still not understood, and as regards 'component scale' modelling, which relies heavily on empirical representations of wall boiling. Accurate models of these phenomena at sub-milli-metric scale are capable of elucidating the various processes and to produce quantitative data needed for up-scaling. Within this context, Direct Numerical Simulation (DNS) represents a powerful tool for CFD analysis of boiling flows. In this contribution, DNS coupled with an Interface Tracking method (Y. Sato, B. Niceno, Journal of Computational Physics, Volume 249, 15 September 2013, Pages 127-161) are used to analyse the hydrodynamics and heat transfer associated with heat diffusion controlled bubble growth at a solid substrate during nucleate flow boiling. The growth of successive bubbles from a single nucleation site is simulated with a computational model that includes heat conduction in the solid substrate and evaporation from the liquid film (micro-layer) present beneath the bubble. Bubble evolution is investigated and the additional (with respect to single phase convection) heat transfer mechanisms due to the ebullition cycle are quantified. The simulations show that latent heat exchange due to evaporation in the micro-layer and sensible heat exchange during the waiting time after bubble departure are the main heat transfer mechanisms. It is found that the presence of an imposed flow normal to the bubble rising path determines a complex velocity and temperature distribution near the nucleation site. This conditions can result in bubble sliding, and influence bubble shape, departure diameter and departure frequency

The influence of temperature and P/P0 upon cationic exchange constants

International Nuclear Information System (INIS)

Blanc, P.; Vieillard, P.; Gailhanou, H.; Gaboreau, S.; Gaucher, E.C.; Giffaut, E.

2010-01-01

uncertainties coming from the difference between anhydrous end-members term. On the other hand, we show that this last relation may be used in order to integrate exchange in the thermodynamic functions of theoretical clay end members, thus avoiding inconsistencies in modeling works implying both exchange and equilibrium constants. Lacking of experimental data only a limited verification of the model could be done, using Inoue and Minato (1979) results for Ca/K exchange on smectite

A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief

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Inoue S

2017-08-01

Full Text Available Satoshi Inoue,1 Yoji Saito,2 Satoru Tsuneto,3 Etsuko Aruga,4 Azusa Ide,1 Yasuyuki Kakurai5 1Clinical Development Department, R&D Division, Daiichi Sankyo, Tokyo,2Department of Anesthesiology, Faculty of Medicine, Shimane University, Shimane, 3Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, 4Department of Palliative Medicine, School of Medicine, Teikyo University, Tokyo, 5Biostatistics and Data Management Department, R&D Division, Daiichi Sankyo, Tokyo, Japan Background: In Japan, there are limited options for switching opioid analgesics. Hydromorphone is an opioid analgesic that is routinely used instead of morphine for cancer pain; however, it is not yet available in Japan. The aim of this study was to assess the efficacy and safety of hydromorphone (DS-7113b extended-release tablets in opioid-naïve patients with cancer pain not relieved by non-opioid analgesics.Subjects and methods: This was a multicenter, randomized, double-blind, parallel-group trial. A double-dummy method was used for blinding. Each randomized subject received either hydromorphone extended-release tablets plus placebo oxycodone hydrochloride extended-release tablets 4 mg/day (n=88 or placebo hydromorphone extended-release tablets plus oxycodone hydrochloride extended-release tablets 10 mg/day (n=93 orally for 7 days (once-daily dosing for hydromorphone and twice-daily dosing for oxycodone. The doses were adjusted as necessary. Efficacy was evaluated by change in visual analog scale (VAS score from baseline to completion of treatment.Results: The between-group difference in least squares mean changes in VAS score from baseline to completion or discontinuation of treatment was −0.4 mm (95% CI −5.9 to 5 mm by analysis of covariance where the baseline VAS score was used as a covariate. The upper limit of the 95% CI was below 10 mm, which was predefined as the noninferiority limit. This verified the noninferiority of hydromorphone tablets

Reliability and validity of the Athens Insomnia Scale in chronic pain patients

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Enomoto K

2018-04-01

Full Text Available Kiyoka Enomoto,1–3 Tomonori Adachi,2–4 Keiko Yamada,5 Daisuke Inoue,2,6 Miho Nakanishi,7 Tomohiko Nishigami,2,8 Masahiko Shibata1,2 ¹Department of Pain Medicine, Osaka University Graduate School of Medicine, Suita, Japan; 2Center for Pain Management, Osaka University Hospital, Suita, Japan; 3Department of Anesthesiology, Interdisciplinary Pain Management Center, Shiga University of Medical Science Hospital, Otsu, Japan; 4Japan Society for the Promotion of Science (JSPS, Tokyo, Japan; 5Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Japan; 6Department of Occupational Therapy, Osaka College of Rehabilitation, Osaka, Japan; 7Department of Anesthesiology, Shiga University of Medical Science, Otsu, Japan; 8Department of Nursing and Physical Therapy, Konan Woman’s University, Kobe, Japan Purpose: To confirm the psychometric properties of the Athens Insomnia Scale (AIS among Japanese chronic pain patients.Patients and methods: In total, 144 outpatients were asked to complete questionnaires comprising the AIS and other study measures. According to the original article, the AIS has 2 versions: the AIS-8 (full version and the AIS-5 (brief version. To validate the AIS-8 and AIS-5 among chronic pain patients, we confirmed: 1 factor structure by confirmatory factor analysis; 2 internal consistency by Cronbach’s a; 3 test–retest reliability using with interclass correlation coefficients; 4 known-group validity; 5 concurrent validity; and 6 cut-off values by receiver operating characteristic analysis. In addition, semi-structured interviews were conducted to assess the participants’ sleep disturbance. If the participants had any sleep complaints, including difficulty in initiating sleep, difficulty in maintaining sleep, and early morning awakening, they were defined as insomnia symptoms.Results: A 2-factor model of the AIS-8 and 1-factor model of the AIS-5 demonstrated good fit. The AIS had

IEC Information Bulletin, No. 42, Fourth Quarter 2012

International Nuclear Information System (INIS)

2013-04-01

The Fukushima Ministerial Conference on Nuclear Safety, organized by Japan in co-sponsorship with the IAEA, was held from 15 to 17 December 2012 in the Fukushima Prefecture, Japan. This Conference provided yet another opportunity to share with the international community, at the ministerial and expert levels, further knowledge and lessons learned from the accident at TEPCO's Fukushima Daiichi Nuclear Power Station (the Fukushima Daiichi accident) and to further enhance transparency. Some 114 countries and 11 international organizations attended the conference. Participants discussed the progress of international efforts aimed at strengthening nuclear safety, including through the implementation of the IAEA Nuclear Safety Action Plan, as well as measures to protect people and the environment from ionizing radiation. In his closing remarks, Denis Flory, the IAEA's Deputy Director General in charge of Nuclear Safety and Security, observed that: 'The Conference has provided a good occasion to reconfirm commitments to nuclear safety,' noting that it had also provided a chance to grasp first-hand the 'unbelievably complex and harsh conditions' in which workers at the plant had to react to the accident and the complexity of the ongoing work there. The Conference concluded with the presentation of Chairperson Summaries from the three expert Working Sessions. During the Conference IAEA Director General, Yukiya Amano, and the Governor of Fukushima Prefecture, Yuhei Sato, signed a Memorandum of Cooperation confirming their willingness to implement concrete projects to help alleviate the consequences of the accident at TEPCO's Fukushima Daiichi Nuclear Power Station. The Memorandum includes arrangements to promote cooperation in two key areas, namely: (i) radiation monitoring and remediation between the IAEA and Fukushima Prefecture, and (ii) human health between the IAEA and Fukushima Medical University. The Memorandum also highlights plans for a training centre in Fukushima

Rheological structure of a lithosphere-asthenosphere boundary zone, decoded from EBSD analysis of mantle xenoliths from Ichinomegata, NE Japan

Science.gov (United States)

Sato, Y.; Ozawa, K.

2017-12-01

Mantle xenoliths are fragments of mantle materials entrapped in alkali basalts or kimberlites and transported to the surface (Nixon, 1987). They provide information on rheological, thermal, chemical, petrological structures of the upper mantle (e.g. Green et al., 2010; McKenzie and Bickle, 1988; O'Reilly and Griffin, 1996). They potentially represent materials from a boundary zone of lithosphere and asthenosphere (LABZ), where the heat transportation mechanism changes from convection to conduction (Sleep, 2005, 2006). However, difficulties in geobarometry for spinel peridotite (e.g. O'Reilly et al., 1997) have hampered our understanding of shallow LABZ. Ichinomegata located in the back-arc side of NE Japan is a latest Pleistocene andesitic-dacitic volcano yielding spinel peridotite xenoliths (Katsui et al., 1979). Through our works (Sato and Ozawa, 2016, 2017a, 2017b), we have overcome difficulties in geobarometry of spinel peridotites and gained accurate thermal structure (0.74-1.60 GPa, 832-1084 °C) from eight of the nine examined xenoliths. The rheological and chemical features suggest drastic changes: undeformed (granular), depleted, subsolidus mantle representing lithospheric mantle (ca. 28-35 km) and deformed (porphyroclastic), fertile, hydrous supersolidus mantle representing rheological LABZ (ca. 35-54 km). We investigate depth dependent variation of crystallographic preferred orientation (CPO) of constituent minerals of the xenoliths by electron back-scattered diffraction analysis (using JSM-7000F with a CCD detector and the CHANNEL5 software at the University of Tokyo). A shallower (ca. 32 km) sample with tabulargranular texture and coarse olivine size (0.92 mm) has A-type olivine CPO with [100] maximum as reported by Satsukawa and Michibayashi (2014) (hereafter SM14), whereas a deep (ca. 51 km) sample with porphyroclastic texture and finer olivine size (0.46 mm) has CPO with weaker fabric intensity characterized by a [100] girdle similar to AG-type and

Real-time functional magnetic resonance imaging in obsessive-compulsive disorder

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Gonçalves ÓF

2017-07-01

Full Text Available Óscar F Gonçalves,1–3 Marcelo C Batistuzzo,4 João R Sato5 1Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal; 2Spaulding Neuromodulation Center, Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 3Social and Cognitive Neuroscience Laboratory, Center for Health and Biological Sciences, Mackenzie Presbyterian University, 4Department and Institute of Psychiatry, University of São Paulo Medical School (FMUSP, 5Mathematics, Computing, and Cognition Center, Universidade Federal do ABC – UFABC, São Paulo, Brazil Abstract: The current literature provides substantial evidence of brain alterations associated with obsessive-compulsive disorder (OCD symptoms (eg, checking, cleaning/decontamination, counting compulsions; harm or sexual, symmetry/exactness obsessions, and emotional problems (eg, defensive/appetitive emotional imbalance, disgust, guilt, shame, and fear learning/extinction and cognitive impairments associated with this disorder (eg, inhibitory control, working memory, cognitive flexibility. Building on this evidence, new clinical trials can now target specific brain regions/networks. Real-time functional magnetic resonance imaging (rtfMRI was introduced as a new therapeutic tool for the self-regulation of brain–mind. In this review, we describe initial trials testing the use of rtfMRI to target brain regions associated with specific OCD symptoms (eg, contamination, and other mind–brain processes (eg, cognitive – working memory, inhibitory control, emotional – defensive, appetitive systems, fear reduction through counter-conditioning found impaired in OCD patients. While this is a novel topic of research, initial evidence shows the promise of using rtfMRI in training the self-regulation of brain regions and mental processes associated with OCD. Additionally, studies with

Dangerous human-made interference with climate: a GISS modelE study

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J. Hansen

2007-01-01

Full Text Available We investigate the issue of "dangerous human-made interference with climate" using simulations with GISS modelE driven by measured or estimated forcings for 1880–2003 and extended to 2100 for IPCC greenhouse gas scenarios as well as the "alternative" scenario of Hansen and Sato (2004. Identification of "dangerous" effects is partly subjective, but we find evidence that added global warming of more than 1°C above the level in 2000 has effects that may be highly disruptive. The alternative scenario, with peak added forcing ~1.5 W/m2 in 2100, keeps further global warming under 1°C if climate sensitivity is ~3°C or less for doubled CO2. The alternative scenario keeps mean regional seasonal warming within 2σ (standard deviations of 20th century variability, but other scenarios yield regional changes of 5–10σ, i.e. mean conditions outside the range of local experience. We conclude that a CO2 level exceeding about 450 ppm is "dangerous", but reduction of non-CO2 forcings can provide modest relief on the CO2 constraint. We discuss three specific sub-global topics: Arctic climate change, tropical storm intensification, and ice sheet stability. We suggest that Arctic climate change has been driven as much by pollutants (O3, its precursor CH4, and soot as by CO2, offering hope that dual efforts to reduce pollutants and slow CO2 growth could minimize Arctic change. Simulated recent ocean warming in the region of Atlantic hurricane formation is comparable to observations, suggesting that greenhouse gases (GHGs may have contributed to a trend toward greater hurricane intensities. Increasing GHGs cause significant warming in our model in submarine regions of ice shelves and shallow methane hydrates, raising concern about the potential for accelerating sea level rise and future positive feedback from methane release. Growth of non-CO2 forcings has slowed in recent years, but CO2 emissions are now surging well above the alternative scenario. Prompt

Comparison of vessel enhancement algorithms applied to time-of-flight MRA images for cerebrovascular segmentation.

Science.gov (United States)

Phellan, Renzo; Forkert, Nils D

2017-11-01

Vessel enhancement algorithms are often used as a preprocessing step for vessel segmentation in medical images to improve the overall segmentation accuracy. Each algorithm uses different characteristics to enhance vessels, such that the most suitable algorithm may vary for different applications. This paper presents a comparative analysis of the accuracy gains in vessel segmentation generated by the use of nine vessel enhancement algorithms: Multiscale vesselness using the formulas described by Erdt (MSE), Frangi (MSF), and Sato (MSS), optimally oriented flux (OOF), ranking orientations responses path operator (RORPO), the regularized Perona-Malik approach (RPM), vessel enhanced diffusion (VED), hybrid diffusion with continuous switch (HDCS), and the white top hat algorithm (WTH). The filters were evaluated and compared based on time-of-flight MRA datasets and corresponding manual segmentations from 5 healthy subjects and 10 patients with an arteriovenous malformation. Additionally, five synthetic angiographic datasets with corresponding ground truth segmentation were generated with three different noise levels (low, medium, and high) and also used for comparison. The parameters for each algorithm and subsequent segmentation were optimized using leave-one-out cross evaluation. The Dice coefficient, Matthews correlation coefficient, area under the ROC curve, number of connected components, and true positives were used for comparison. The results of this study suggest that vessel enhancement algorithms do not always lead to more accurate segmentation results compared to segmenting nonenhanced images directly. Multiscale vesselness algorithms, such as MSE, MSF, and MSS proved to be robust to noise, while diffusion-based filters, such as RPM, VED, and HDCS ranked in the top of the list in scenarios with medium or no noise. Filters that assume tubular-shapes, such as MSE, MSF, MSS, OOF, RORPO, and VED show a decrease in accuracy when considering patients with an AVM

Systematic review of raloxifene in postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia

Directory of Open Access Journals (Sweden)

Fujiwara S

2014-11-01

Full Text Available Saeko Fujiwara,1 Etsuro Hamaya,2 Masayo Sato,2 Peita Graham-Clarke,3 Jennifer A Flynn,2 Russel Burge41Hiroshima Atomic Bomb Casualty Council, Hiroshima, Japan; 2Lilly Research Laboratories Japan, Eli Lilly Japan K.K., Kobe, Japan; 3Global Health Outcomes, Eli Lilly Australia, Sydney, NSW, Australia; 4Global Health Outcomes, Eli Lilly and Company, Indianapolis, IN, USAPurpose: To systematically review the literature describing the efficacy, effectiveness, and safety of raloxifene for postmenopausal Japanese women with osteoporosis or low bone mass (osteopenia.Materials and methods: Medline via PubMed and Embase was systematically searched using prespecified terms. Retrieved publications were screened and included if they described randomized controlled trials or observational studies of postmenopausal Japanese women with osteoporosis or osteopenia treated with raloxifene and reported one or more outcome measures (change in bone mineral density [BMD]; fracture incidence; change in bone-turnover markers, hip structural geometry, or blood–lipid profile; occurrence of adverse events; and change in quality of life or pain. Excluded publications were case studies, editorials, letters to the editor, narrative reviews, or publications from non-peer-reviewed journals; multidrug, multicountry, or multidisease studies with no drug-, country-, or disease-level analysis; or studies of participants on dialysis.Results: Of the 292 publications retrieved, 15 publications (seven randomized controlled trials, eight observational studies were included for review. Overall findings were statistically significant increases in BMD of the lumbar spine (nine publications, but not the hip region (eight publications, a low incidence of vertebral fracture (three publications, decreases in markers of bone turnover (eleven publications, improved hip structural geometry (two publications, improved blood–lipid profiles (five publications, a low incidence of hot flushes

Magnetic nanoparticles of Fe3O4 enhance docetaxel-induced prostate cancer cell death

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Sato A

2013-08-01

Full Text Available Akiko Sato,1 Naoki Itcho,1 Hitoshi Ishiguro,2,3 Daiki Okamoto,1 Naohito Kobayashi,4 Kazuaki Kawai,5 Hiroshi Kasai,5 Daisuke Kurioka,1 Hiroji Uemura,2 Yoshinobu Kubota,2 Masatoshi Watanabe11Laboratory for Medical Engineering, Division of Materials Science and Chemical Engineering, Graduate School of Engineering, Yokohama National University, Yokohama, Japan; 2Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; 3Photocatalyst Group, Kanagawa Academy of Science and Technology, Kawasaki, Japan; 4Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; 5Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, JapanAbstract: Docetaxel (DTX is one of the most important anticancer drugs; however, the severity of its adverse effects detracts from its practical use in the clinic. Magnetic nanoparticles of Fe3O4 (MgNPs-Fe3O4 can enhance the delivery and efficacy of anticancer drugs. We investigated the effects of MgNPs-Fe3O4 or DTX alone, and in combination with prostate cancer cell growth in vitro, as well as with the mechanism underlying the cytotoxic effects. MgNPs-Fe3O4 caused dose-dependent increases in reactive oxygen species levels in DU145, PC-3, and LNCaP cells; 8-hydroxydeoxyguanosine levels were also elevated. MgNPs-Fe3O4 alone reduced the viability of LNCaP and PC-3 cells; however, MgNPs-Fe3O4 enhanced the cytotoxic effect of a low dose of DTX in all three cell lines. MgNPs-Fe3O4 also augmented the percentage of DU145 cells undergoing apoptosis following treatment with low dose DTX. Expression of nuclear transcription factor κB in DU145 was not affected by MgNPs-Fe3O4 or DTX alone; however, combined treatment suppressed nuclear transcription factor κB expression. These findings offer the possibility that MgNPs-Fe3O4–low dose DTX combination therapy may be

Cosmic Ray Modulation and Radiation Dose of Aircrews During Possible Grand Minimum

Science.gov (United States)

Miyake, S.; Kataoka, R.; Sato, T.; Imada, S.; Miyahara, H.; Shiota, D.; Matsumoto, T.; Ueno, H.

2017-12-01

the new model for the heliospheric environmental change will be presented at the meeting. [1] S. Miyake, R. Kataoka, and T. Sato, Space Weather, 15, 589-605, 2017.

Comparison of changes in oxygenated hemoglobin during the tree-drawing task between patients with schizophrenia and healthy controls

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Nakano S

2018-04-01

Full Text Available Shinya Nakano,1,2 Yoshihisa Shoji,1,3 Kiichiro Morita,1,3 Hiroyasu Igimi,1,4 Mamoru Sato,1,3 Youhei Ishii,1 Akihiko Kondo,1 Naohisa Uchimura1,3 1Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, Kurume, Japan; 2Department of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Japan; 3Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan; 4Department of Neuropsychiatry, Horikawa Hospital, Medical Corporation Association Horikawakai, Kurume, Japan Background: Tree-drawing test is used as a projective psychological test that expresses the abnormal internal experience in patients with schizophrenia (SZ. Despite the widely accepted view that the cognitive function is involved in characteristic tree-drawing in patients with SZ, no study has psychophysiologically examined it. The present study aimed to investigate the involvement of cognitive function during tree-drawing in patients with SZ. For that purpose, we evaluated the brain function in patients with SZ during a tree-drawing task by using near-infrared spectroscopy (NIRS and compared them with those in healthy controls. Patients and methods: The subjects were 28 healthy controls and 28 patients with SZ. Changes in the oxygenated hemoglobin ([oxy-Hb] concentration in both the groups during the task of drawing a tree imagined freely (free-drawing task and the task of copying an illustration of a tree (copying task were measured by using NIRS. Results: Because of the difference between the task conditions, [oxy-Hb] levels in controls during the free-drawing task were higher than that during the copying task at the bilateral frontal pole regions and left inferior frontal region. Because of the difference between the groups, [oxy-Hb] levels at the left middle frontal region, bilateral inferior frontal regions, bilateral inferior parietal regions, and left superior temporal region during the free-drawing task in patients were

Long-period Ground Motion Simulation in the Osaka Basin during the 2011 Great Tohoku Earthquake

Science.gov (United States)

Iwata, T.; Kubo, H.; Asano, K.; Sato, K.; Aoi, S.

2014-12-01

Large amplitude long-period ground motions (1-10s) with long duration were observed in the Osaka sedimentary basin during the 2011 Tohoku earthquake (Mw9.0) and its aftershock (Ibaraki-Oki, Mw7.7), which is about 600 km away from the source regions. Sato et al. (2013) analyzed strong ground motion records from the source region to the Osaka basin and showed the following characteristics. (1) In the period range of 1 to 10s, the amplitude of horizontal components of the ground motion at the site-specific period is amplified in the Osaka basin sites. The predominant period is about 7s in the bay area where the largest pSv were observed. (2) The velocity Fourier amplitude spectra with their predominant period of around 7s are observed at the bedrock sites surrounding the Osaka basin. Those characteristics were observed during both of the mainshock and the largest aftershock. Therefore, large long-period ground motions in the Osaka basin are generated by the combination of propagation-path and basin effects. They simulated ground motions due to the largest aftershock as a simple point source model using three-dimensional FDM (GMS; Aoi and Fujiwara, 1999). They used a three-dimensional velocity structure based on the Japan Integrated Velocity Structure Model (JIVSM, Koketsu et al., 2012), with the minimum effective period of the computation of 3s. Their simulation result reproduced the observation characteristics well and it validates the applicability of the JIVSM for the long period ground motion simulation. In this study, we try to simulate long-period ground motions during the mainshock. The source model we used for the simulation is based on the SMGA model obtained by Asano and Iwata (2012). We succeed to simulate long-period ground motion propagation from Kanto area to the Osaka basin fairly well. The long-period ground motion simulations with the several Osaka basin velocity structure models are done for improving the model applicability. We used strong motion

Beyond the ENDF format: A modern nuclear database structure. SG38 meeting, JAEA Tokai site, 9-11 December 2013

International Nuclear Information System (INIS)

Fukahori, T.; McNabb, D.; Mattoon, C.; Kugo, T.; Yokoyama, K.; Suyama, K.; Nishihara, K.; Konno, C.; Sato, T.; Brown, D.; White, M.; Beck, B.; Sinitsa, V.; Dunn, M.

2013-12-01

WPEC subgroup 38 (SG38) was formed to develop a new structure for storing nuclear reaction data, that is meant to eventually replace ENDF-6 as the standard way to store and share evaluations. The work of SG38 covers the following tasks: Designing flexible, general-purpose data containers; Determining a logical and easy-to-understand top-level hierarchy for storing evaluated nuclear reaction data; Creating a particle database for storing particles, masses and level schemes; Specifying the infrastructure (plotting, processing, etc.) that must accompany the new structure; Developing an Application Programming Interface or API to allow other codes to access data stored in the new structure; Specifying what tests need to be implemented for quality assurance of the new structure and associated infrastructure; Ensuring documentation and governance of the structure and associated infrastructure. This document is the proceedings of the third subgroup meeting which took place at the Tokai site of the Japan Atomic Energy Agency (JAEA) in Japan, on 9-11 December 2013 It comprises all the available presentations (slides) given by the participants as well as one draft paper: A - Introduction: - Welcome (T. Fukahori); - Reviewing our implementation plan (D. McNabb); - Overview of the SG38 wiki (C. Mattoon); B - Feedback from nuclear data users: - Application of nuclear data to light water reactor core analysis (T. Kugo); - Application of nuclear data to fast reactor analysis and design (K. Yokoyama); - Request for the format of the evaluated nuclear data file for the criticality safety evaluation (K. Suyama); - Sensitivity and uncertainty analysis for a minor-actinide transmuter with JENDL- 4.0 (K. Nishihara); - Application of nuclear data libraries in fusion neutronics and some comments (C. Konno); - Particle and heavy ion transport code system PHITS (T. Sato); C - Review of the project sub-tasks: - Top level organization of nuclear data (D. Brown); Documentation: Requirements

IEC Information Bulletin, No. 42, Fourth Quarter 2012

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-04-15

The Fukushima Ministerial Conference on Nuclear Safety, organized by Japan in co-sponsorship with the IAEA, was held from 15 to 17 December 2012 in the Fukushima Prefecture, Japan. This Conference provided yet another opportunity to share with the international community, at the ministerial and expert levels, further knowledge and lessons learned from the accident at TEPCO's Fukushima Daiichi Nuclear Power Station (the Fukushima Daiichi accident) and to further enhance transparency. Some 114 countries and 11 international organizations attended the conference. Participants discussed the progress of international efforts aimed at strengthening nuclear safety, including through the implementation of the IAEA Nuclear Safety Action Plan, as well as measures to protect people and the environment from ionizing radiation. In his closing remarks, Denis Flory, the IAEA's Deputy Director General in charge of Nuclear Safety and Security, observed that: 'The Conference has provided a good occasion to reconfirm commitments to nuclear safety,' noting that it had also provided a chance to grasp first-hand the 'unbelievably complex and harsh conditions' in which workers at the plant had to react to the accident and the complexity of the ongoing work there. The Conference concluded with the presentation of Chairperson Summaries from the three expert Working Sessions. During the Conference IAEA Director General, Yukiya Amano, and the Governor of Fukushima Prefecture, Yuhei Sato, signed a Memorandum of Cooperation confirming their willingness to implement concrete projects to help alleviate the consequences of the accident at TEPCO's Fukushima Daiichi Nuclear Power Station. The Memorandum includes arrangements to promote cooperation in two key areas, namely: (i) radiation monitoring and remediation between the IAEA and Fukushima Prefecture, and (ii) human health between the IAEA and Fukushima Medical University. The Memorandum also highlights plans for a training centre in Fukushima

The economic and humanistic costs of chronic lower back pain in Japan

Directory of Open Access Journals (Sweden)

Montgomery W

2017-06-01

Full Text Available William Montgomery,1 Masayo Sato,2 Yasuo Nagasaka,2 Jeffrey Vietri3 1Global Patient Outcomes & Real World Evidence, Eli Lilly Australia Pty Ltd., West Ryde, Australia; 2Medical Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 3Kantar Health, Horsham, PA, USA Background: Few data are available that provide estimates of the economic impact of chronic lower back pain (CLBP in Japan. The current study estimated the patient burden and the direct and indirect medical costs associated with CLBP in Japan using data from a large cross-sectional patient survey. CLBP was hypothesized to be associated with a considerable burden of illness and a large economic impact.Methods: Study participants completed the Japan National Health and Wellness Survey in 2014, which included measures of health-related quality of life (HRQoL, work impairment, impairment to daily activities, and healthcare service use. Data from those reporting CLBP (N=392 were contrasted against those from matched controls without back pain, using age and sex-adjusted models.Results: CLBP patients reported significantly lower HRQoL relative to matched controls. Age- and sex-adjusted models estimated mean annual per patient direct and indirect costs attributable to CLBP to be ¥1,820,297 ($15,239 or €12,551 and ¥1,479,899 ($12,389 or €10,203, respectively, with the majority of direct costs related to hospital expenses (¥1,584,759, which is equivalent to $13,267 and €10,927. In estimating the economic impact of CLBP on society, the CLBP respondents were estimated to include 1,508,524 individuals when extrapolated to the Japanese population (815,461 of them employed. Ultimately, this represented approximately ¥1.2 trillion ($10 billion and €8.3 billion per year in lost productivity at the time of this study.Conclusion: This study of patients with CLBP in Japan has shown it to be associated with a significant burden on patients and to have a considerable negative impact on the

Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry

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Hashimoto N

2014-10-01

Full Text Available Nobuhiko Hashimoto,1 Shutaro Nakaaki,2 Akiko Kawaguchi,1 Junko Sato,1 Harumasa Kasai,3 Takashi Nakamae,4 Jin Narumoto,4 Jun Miyata,5 Toshi A Furukawa,6,7 Masaru Mimura2 1Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; 2Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; 3Department of Central Radiology, Nagoya City University Hospital, Nagoya, Japan; 4Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 5Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 6Department of Health Promotion and Human Behavior, 7Department of Clinical Epidemiology, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan Background: Although several functional imaging studies have demonstrated that behavior therapy (BT modifies the neural circuits involved in the pathogenesis of obsessive-compulsive disorder (OCD, the structural abnormalities underlying BT-resistant OCD remain unknown. Methods: In this study, we examined the existence of regional structural abnormalities in both the gray matter and the white matter of patients with OCD at baseline using voxel-based morphometry in responders (n=24 and nonresponders (n=15 to subsequent BT. Three-dimensional T1-weighted magnetic resonance imaging was performed before the completion of 12 weeks of BT. Results: Relative to the responders, the nonresponders exhibited significantly smaller gray matter volumes in the right ventromedial prefrontal cortex, the right orbitofrontal cortex, the right precentral gyrus, and the left anterior cingulate cortex. In addition, relative to the responders, the nonresponders exhibited significantly smaller white matter volumes in the left cingulate bundle and the left superior frontal white matter. Conclusion: These results suggest that the brain

Breakdown of lung framework and an increase in pores of Kohn as initial events of emphysema and a cause of reduction in diffusing capacity

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Yoshikawa A

2016-09-01

Full Text Available Akira Yoshikawa,1 Shuntaro Sato,2,3 Tomonori Tanaka,1 Mikiko Hashisako,1,4 Yukio Kashima,5,6 Tomoshi Tsuchiya,7 Naoya Yamasaki,7 Takeshi Nagayasu,7 Hiroshi Yamamoto,2 Junya Fukuoka1,6 1Nagasaki Educational and Diagnostic Center of Pathology (NEDCP, Department of Pathology, 2Clinical Research Center, Nagasaki University Hospital, Nagasaki, 3Division of Biostatistics, Kurume University School of Medicine, Fukuoka, 4Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 5Department of Pathology, Hyogo Prefectural Awaji Medical Center, Sumoto, 6Department of Pathology, 7Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Purpose: Pulmonary emphysema is the pathological prototype of chronic obstructive pulmonary disease and is also associated with other lung diseases. We considered that observation with different approaches may provide new insights for the pathogenesis of emphysema. Patients and methods: We reviewed tissue blocks of the lungs of 25 cases with/without emphysema and applied a three-dimensional observation method to the blocks. Based on the three-dimensional characteristics of the alveolar structure, we considered one face of the alveolar polyhedron as a structural unit of alveoli and called it a framework unit (FU. We categorized FUs based on their morphological characteristics and counted their number to evaluate the destructive changes in alveoli. We also evaluated the number and the area of pores of Kohn in FUs. We performed linear regression analysis to estimate the effect of these data on pulmonary function tests. Results: In multivariable regression analysis, a decrease in the number of FUs without an alveolar wall led to a significant decrease in the diffusing capacity of the lung for carbon monoxide (DLCO and DLCO per unit alveolar volume, and an increase in the area of

Avaliação dos níveis séricos de testosterona em pacientes com síndrome da apneia obstrutiva do sono Evaluation of testosterone serum levels in patients with obstructive sleep apnea syndrome

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Fernando Drimel Molina

2011-02-01

Full Text Available Homens com síndrome da apneia obstrutiva do sono (SAOS podem apresentar diminuição dos níveis de testosterona devido à hipóxia. OBJETIVOS: Relacionar os níveis séricos da testosterona, em pacientes com SAOS, com parâmetros clínico-laboratoriais. MATERIAL E MÉTODOS: Foram revisados 103 prontuários de pacientes com SAOS, entre os anos de 2002 e 2009, e coletados os seguintes dados: idade à época da realização da polissonografia, valores do Hematócrito e Hemoglobina, nível sérico da testosterona total, IMC, índice de apneia/hipopneia(IAH e SatO2. FORMA DO ESTUDO: Estudo de casos retrospectivo em corte transversal. RESULTADOS: 79 pacientes (77% não apresentaram alteração hormonal e 24 (23% apresentaram níveis séricos inferiores. Dos pacientes com testosterona normal 70% estavam com sobrepeso, enquanto que 63% com testosterona alterada apresentaram obesidade grau I (pMales with obstructive sleep apnea syndrome (OSAS may present decreased testosterone serum levels because of hypoxemia. AIM: To correlate testosterone levels in OSAS patients with laboratory parameters. MATERIAL AND METHODS: 103 registries of OSAS patients were reviewed from 2002 to 2009. The following data collected: age when polysomnography was done, hematocrit and hemoglobin levels, total testosterone serum levels, BMI, apnea/hypopnea index (AHI, and O2 saturation. STUDY DESIGN: A cross-sectional retrospective case study. RESULTS: 79 patients (77% had no hormonal changes, and 24 patients (23% had decreased serum levels. In patients with normal testosterone levels, 70% were overweight; 63% with altered testosterone levels had obesity grade I (p<0.05. Patients with altered testosterone levels had significantly lower average doses of Ht, Hb and androgen compared to patients without altered androgen levels. The average BMI of patients with altered hormone levels was significantly higher compared to patients with normal hormone levels. CONCLUSIONS: The relationship

Dangerous human-made interference with climate: a GISS modelE study

International Nuclear Information System (INIS)

Hansen, J.; Lacis, A.; Miller, R.; Schmidt, G.A.; Russell, G.; Canuto, V.; Del Genio, A.; Hall, T.; Kiang, N.Y.; Rind, D.; Romanou, A.; Shindell, D.; Sun, S.; Hansen, J.; Sato, M.; Kharecha, P.; Nazarenko, L.; Aleinov, I.; Bauer, S.; Chandler, M.; Faluvegi, G.; Jonas, J.; Koch, D.; Lerner, J.; Perlwitz, Ju.; Unger, N.; Zhang, S.; Ruedy, R.; Lo, K.; Cheng, Y.; Oinas, V.; Schmunk, R.; Tausnev, N.; Yao, M.; Lacis, A.; Schmidt, G.A.; Del Genio, A.; Rind, D.; Romanou, A.; Shindell, D.; Thresher, D.; Miller, R.; Cairns, B.; Hall, T.; Perlwitz, Ja.; Baum, E.; Cohen, A.; Fleming, E.; Jackman, C.; Labow, G.; Friend, A.; Kelley, M.

2007-01-01

We investigate the issue of 'dangerous human-made interference with climate' using simulations with GISS modelE driven by measured or estimated forcing for 1880-2003 and extended to 2100 for IPCC greenhouse gas scenarios as well as the 'alternative' scenario of Hansen and Sato (2004). Identification of 'dangerous' effects is partly subjective, but we find evidence that added global warming of more than 1 degrees C above the level in 2000 has effects that may be highly disruptive. The alternative scenario, with peak added forcing similar to 1.5 W/m 2 in 2100, keeps further global warming under 1 degrees C if climate sensitivity is similar to 3 degrees C or less for doubled CO 2 . The alternative scenario keeps mean regional seasonal warming within 2 σ (standard deviations) of 20. century variability, but other scenarios yield regional changes of 5-10 σ, i.e. mean conditions outside the range of local experience. We conclude that a CO 2 level exceeding about 450 ppm is 'dangerous', but reduction of non-CO 2 forcing can provide modest relief on the CO 2 constraint. We discuss three specific sub-global topics: Arctic climate change, tropical storm intensification, and ice sheet stability. We suggest that Arctic climate change has been driven as much by pollutants (O 3 , its precursor CH 4 , and soot) as by CO 2 , offering hope that dual efforts to reduce pollutants and slow CO 2 growth could minimize Arctic change. Simulated recent ocean warming in the region of Atlantic hurricane formation is comparable to observations, suggesting that greenhouse gases (GHGs) may have contributed to a trend toward greater hurricane intensities. Increasing GHGs cause significant warming in our model in submarine regions of ice shelves and shallow methane hydrates, raising concern about the potential for accelerating sea level rise and future positive feedback from methane release. Growth of non-CO 2 forcing has slowed in recent years, but CO 2 emissions are now surging well above the

Nitrate from Drinking Water and Diet and Bladder Cancer Among Postmenopausal Women in Iowa.

Science.gov (United States)

Jones, Rena R; Weyer, Peter J; DellaValle, Curt T; Inoue-Choi, Maki; Anderson, Kristin E; Cantor, Kenneth P; Krasner, Stuart; Robien, Kim; Freeman, Laura E Beane; Silverman, Debra T; Ward, Mary H

2016-11-01

nitrite intakes were not associated with bladder cancer. Long-term ingestion of elevated nitrate in drinking water was associated with an increased risk of bladder cancer among postmenopausal women. Citation: Jones RR, Weyer PJ, DellaValle CT, Inoue-Choi M, Anderson KE, Cantor KP, Krasner S, Robien K, Beane Freeman LE, Silverman DT, Ward MH. 2016. Nitrate from drinking water and diet and bladder cancer among postmenopausal women in Iowa. Environ Health Perspect 124:1751-1758; http://dx.doi.org/10.1289/EHP191.

Metabolic fate of poly-(lactic-co-glycolic acid-based curcumin nanoparticles following oral administration

Directory of Open Access Journals (Sweden)

Harigae T

2016-06-01

Full Text Available Takahiro Harigae,1 Kiyotaka Nakagawa,1 Taiki Miyazawa,2 Nao Inoue,3 Fumiko Kimura,1 Ikuo Ikeda,3 Teruo Miyazawa4,5 1Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan; 2Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA; 3Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, 4Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center, 5Food and Health Science Research Unit, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan Purpose: Curcumin (CUR, the main polyphenol in turmeric, is poorly absorbed and rapidly metabolized following oral administration, which severely curtails its bioavailability. Poly-(lactic-co-glycolic acid-based CUR nanoparticles (CUR-NP have recently been suggested to improve CUR bioavailability, but this has not been fully verified. Specifically, no data are available about curcumin glucuronide (CURG, the major metabolite of CUR found in the plasma following oral administration of CUR-NP. Herein, we investigated the absorption and metabolism of CUR-NP and evaluated whether CUR-NP improves CUR bioavailability.Methods: Following oral administration of CUR-NP in rats, we analyzed the plasma and organ distribution of CUR and its metabolites using high-performance liquid chromatography-tandem mass spectrometry. To elucidate the mechanism of increased intestinal absorption of CUR-NP, we prepared mixed micelles comprised of phosphatidylcholine and bile salts and examined the micellar solubility of CUR-NP. Additionally, we investigated the cellular incorporation of the resultant micelles into differentiated Caco-2 human intestinal cells.Results: Following in vivo administration of CUR-NP, CUR was effectively absorbed and present mainly as CURG in the plasma which contained significant amounts of the metabolite compared with

Similar foliage area but contrasting foliage biomass between young beech and spruce stands / Porovnateľná plocha avšak kontrastná biomasa asimilačných orgánov medzi mladými porastmi buka a smreka

Directory of Open Access Journals (Sweden)

Konôpka Bohdan

2014-12-01

Full Text Available Výskum sa zameral na mladé porasty buka lesného (Fagus sylvatica a smreka obyčajného (Picea abies rovnakého veku (12 rokov, veľmi podobných dimenzií stromov, rastúcich na totožnom stanovišti. Na základe odberu vzorníkov celých stromov (všetky časti okrem jemných koreňov sme skonštruovali alometrické vzťahy pre stromové komponenty. Ako nezávislá premenná sa použila hrúbka na báze kmeňa (d0. Modely vyjadrili nielen biomasu konárov, kmeňa, hrubých koreňov a asimilačných orgánov, ale aj plochu asimilačných orgánov a špecifickú listovú plochu (specific leaf area; SLA. Zistili sme, že základné morfologické vlastnosti asimilačných orgánov varírovali pri obidvoch drevinách pozdĺž vertikálneho profilu koruny. V prípade smreka sa zistili odlišné hodnoty plochy ihlíc a SLA medzi jednotlivými ročníkmi ihlíc. Na úrovni stromu mali buky oveľa viac biomasy drevných častí ako smreky, opačná situácia bola pri asimilačných orgánoch. Preto hodnoty podielu medzi biomasou asimilačných orgánov a celkovou biomasou stromu, ako aj pomeru medzi plochou asimilačných orgánov a celkovou biomasou stromu boli výrazne vyššie pri smreku než buku. Na úrovni porastu mala smrečina vyššie hodnoty indexu listovej plochy, t. j. LAI (18,64 m2.m−2 v porovnaní s bučinou (12,77 m2.m−2. Kým biomasa asimilačných orgánov bola 4,6-krát väčšia v smrekovom než v bukovom poraste, biomasa drevných časti bola porovnateľná v obidvoch porastoch. Tieto kontrasty naznačujú výrazne odlišnú rastovú stratégiu, resp. alokáciu biomasy medzi bučinami a smrečinami v mladých štádiách

Escala de sonolência de Epworth na síndroma de apneia obstrutiva do sono: uma subjetividade subestimada

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C. Guimarães

2012-11-01

Full Text Available Resumo: A hipersonolência diurna é uma das manifestações mais relevantes da síndrome da apneia obstrutiva do sono (SAOS e pode ser avaliada quer por testes subjetivos quer por testes objetivos. A escala de sonolência de Epworth (ESE é um instrumento simples e validado que permite avaliar a sonolência diurna no contexto clínico de distúrbios do sono. No entanto, o seu caráter subjetivo pode condicionar a exata expressão do verdadeiro grau de sonolência. O uso clínico da ESE é demonstrado neste trabalho, mostrando que, no mesmo doente em momentos diferentes o score da ESE é díspar e como este score pode estar ou não relacionado em determinadas variáveis.Assim, comparamos o grau de sonolência basal com o grau de sonolência na mesma situação, mas avaliado retrospetivamente após tratamento com pressão positiva contínua das vias aéreas (Automatic Positive Airway Pressure – APAP.Realizamos um estudo prospetivo que incluiu 66 doentes observados na consulta de Patologia do Sono em que, após estudo poligráfico do sono ou cardiorrespiratório domiciliário, foi feito o diagnóstico de SAOS. Os doentes apresentavam uma idade média de 53,3 anos, sendo a maioria do sexo masculino (88%, n = 58. Os doentes preencheram o questionário da ESE no dia da primeira consulta (pré APAP e posteriormente, na consulta de seguimento, preencheram novamente a ESE referente ao período pós-tratamento com APAP e pediu-se, retrospetivamente, nova quantificação da ESE inicial. A média do score da ESE basal foi de 11,8, a retrospetiva de 15,4, com uma diferença média de 3,55 (p < 0,001 t-Test e após terapêutica com APAP 7,4. Não houve correlação entre a diferença do score da ESE (basal retrospetiva com a média de tempo de uso diário do APAP (horas, com o índice de apneia-hipopneia (IAH, com a SatO2 mínima registada

Clinical outcomes of endoscope-assisted vitrectomy for treatment of rhegmatogenous retinal detachment

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Yokoyama S

2017-11-01

Full Text Available Sho Yokoyama,1 Takashi Kojima,2 Toshio Mori,3 Taisuke Matsuda,1 Hiroyuki Sato,3 Norihiko Yoshida,4 Tatsushi Kaga,1 R Theodore Smith,5 Kazuo Ichikawa6 1Department of Ophthalmology, Japan Community Healthcare Organization Chukyo Hospital, Nagoya, Japan; 2Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan; 3Department of Ophthalmology, Iida Municipal Hospital, Iida, Japan; 4Department of Ophthalmology, Japanese Red Cross Gifu Hospital, Gifu, Japan; 5Department of Ophthalmology, New York University School of Medicine, New York, NY, USA; 6Chukyo Eye Clinic, Nagoya, Japan Summary: We evaluated the clinical outcomes for ophthalmic endoscope-assisted vitrectomy in consecutive patients with uncomplicated rhegmatogenous retinal detachment (RRD. The primary success rate was 98.4% (125/127 without performing a posterior drainage retinotomy or using perfluorocarbon liquids (PFCL for subretinal fluid drainage.Purpose: To investigate the clinical outcomes of endoscope-assisted vitrectomy in patients with uncomplicated RRD.Methods: We examined 127 eyes from consecutive patients who underwent repair of RRD by 23- or 25-gauge endoscope-assisted vitrectomy, with a minimum follow-up of 3 months. Eyes with the following criteria were excluded: Giant retinal tears, grade C proliferative vitreoretinopathy, dense vitreous hemorrhage, retinal detachment secondary to other ocular diseases, and prior retinal or vitreous surgery. All cases underwent subretinal fluid drainage, endolaser photocoagulation and fundus inspection were performed under ophthalmic endoscopic observation. Success rate, visual acuity, surgery time and complications were evaluated.Results: Primary and final success rate was 98.4% (125/127 and 100% (127/127, respectively, Surgery time was 59.6±26.3 minutes. The best-corrected visual acuity significantly improved from 20/100 to 20/20 (P<0.0001. There were 2 cases (1.6% of creation of a peripheral drainage retinotomy and 4

Deepest Depth of Seismogenic Layer Within the Crust Beneath Japanese Islands on the Japan Sea Side Using High Resolved Earthquake Catalog and Heat Flux Data

Science.gov (United States)

Matsubara, M.; Yano, T. E.

2017-12-01

Understanding the deepest depth of seismogenic layer is important parameter for the earthquake hazard assessment because this relates to the size of earthquakes caused by the active fault. Using the indexes D90 and D95, defined as the depth above which 90% and 95 % of the whole crustal earthquakes occurred from the surface, as the lower limits of the seismogenic layer. We verified the seismogenic depth for particular earthquakes on the Japan Sea side occurred after the year of 2001. We compared with the actual main shock hypocenter depth, their aftershocks, main slip region on the fault, and depth where the temperature estimated to be 250, 300, and 450 degrees. For D90 and D95, we used two different earthquake catalogs. First, the catalog in which we relocated hypocenters for 12 years between 2001 and 2012 from the NIED Hi-net catalog (JUICE catalog, Yano et al. 2017) for high resolution hypocenter locations (Depth 0.0). This catalog is used to get D95 values. Second, the earthquake catalog redetermined with the 3D velocity structure (Matsubara and Obara, 2011) particularly for getting the D90 value around the costal region. In order to satisfy Gutenberg-Richter magnitude-frequency relation, we chose events M>1.5. We then calculated the D90 and D95 using the same method as Matsubara and Sato (2015). For depths where the temperatures are 250, 300, and 450 degrees are estimated from heat flux measured at Hi-net boreholes (Matsumoto, 2007) and other additional data Sakagawa et al. (2005). Depths are calculated using the steady-state, one-dimensional, heat conduction equation with an exponential decrease in the radioactivity heat generation introduced in Tanaka (2004). The general pattern of our results is consistent with previous studies of D90 as very deep D95 beneath the northern Hokkaido and northern Honshu and very shallow D95 along the volcanic front. We found that our D90/D95 showed the deepest boundary of hypocenter of mainshock, majority of aftershocks, main

U-Pb SHRIMP and Sm-Nd geochronology of the paleoproterozoic Silvania magmatic arc in the neoproproterozoic Brasilia Belt, Goias, Central Brazil

International Nuclear Information System (INIS)

Fischel, D.P.; Pimentel, M.M.; Fuck, R.A; Armstrong, R

2001-01-01

The Brasilia Belt is a large Neoproterozoic orogen formed along the western margin of the Sao Francisco/Congo Craton in central Brazil. It comprises: (i) a thick Meso-Neoproterozoic metasedimentary/sedimentary pile with eastward tectonic vergence; (ii) a large Neoproterozoic juvenile arc in the west (Goias Magmatic Arc); and (iii) a micro-continent (or exotic sialic terrain) formed by Archean rock units (the Crixas -Goias granitegreenstones) and associated Proterozoic formations (Almeida et al. 1981, Fuck et al. 1993,1994, Pimentel et al. 2000a, b). The sialic basement on which the Brasilia Belt sediments were deposited is poorly understood, despite being well exposed in some areas of Goias and Tocantins. Gneiss and volcano-sedimentary units form most of this basement. Early studies have suggested that these rock units are dominantly Archean ( Danni et al. 1982, Marini et al. 1984). However, recent Sm- Nd isotopic studies have indicated that most of them are Paleoproterozoic (Sato 1998, Pimentel et al. 1999a, 2000b). Granite gneiss to the south and east of the Barro Alto mafic-ultramafic layered complex has been dated at 2128+/- 15 Ma (Correia et al. 1997). Calc-alkaline granite gneiss from Almas-Dianopolis is dated at ca. 2.2-2.45 Ga old (U-Pb SHRIMP on zircon and titanite, Cruz et al. 2000). The latter is probably the western extension of Paleoproterozoic rocks which underlie the San Francisco Craton to the east of the northern part of the Brasilia Belt. In central Goias, a large part of the Brasilia Belt is underlain by high-grade metamorphic rocks known as the Anapolis-Itaucu Complex, together with surrounding greenschist to amphibolite facies Mesoto Neoproterozoic cover metasediments of the Araxa group. These rocks represent the main constituent of the internal zone of the Brasilia Belt (Fuck et al. 1994, Pimentel et al. 2000b). Between the Araxa Group, and the easternmost part of the Anapolis-Itaucu Complex a volcano-sedimentary association known as Silvania

Work–family conflict as a mediator between occupational stress and psychological health among mental health nurses in Japan

Directory of Open Access Journals (Sweden)

Sugawara N

2017-03-01

Full Text Available Norio Sugawara,1,2 Kazuma Danjo,3 Hanako Furukori,4 Yasushi Sato,2,5 Tetsu Tomita,2,6 Akira Fujii,7 Taku Nakagami,2,8 Kazuyo Kitaoka,9 Norio Yasui-Furukori2 1Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 2Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Aomori, 3Mizoguchi Mental Hospital, Shizuoka, 4Department of Psychiatry, Kuroishi-Akebono Hospital, Kuroishi, 5Department of Psychiatry, Mutsu General Hospital, Mutsu, 6Department of Psychiatry, Hirosaki-Aiseikai Hospital, Kitazono, Hirosaki, 7Department of Psychiatry, Seihoku-Chuoh Hospital, Goshogawara, Aomori, 8Department of Psychiatry, Odate Municipal General Hospital, Odate, Akita, 9Mental Health Nursing, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan Background: Occupational stress among mental health nurses may affect their psychological health, resulting in reduced performance. To provide high-quality, sustainable nursing care, it is necessary to identify and control the factors associated with psychological health among mental health nurses. The purpose of this study was to examine the role of work–family conflict (WFC in the well-known relationship between occupational stress and psychological health among mental health nurses in Japan. Methods: In this cross-sectional study, data were gathered from 180 mental health nurses who had a coresident child or were married. Data from the Work–Family Conflict Scale, the Generic Job Stress Questionnaire, the Maslach Burnout Inventory-General Survey, and the Center for Epidemiologic Studies for Depression Scale were obtained via self-report questionnaires. The effects of occupational stress and WFC on psychological health were explored by hierarchical linear regression analysis. Results: The relationship between emotional exhaustion and occupational factors, including

Book Reviews

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J. van Goor

1997-07-01

Full Text Available - Peter Boomgaard, Christine Dobbin, Asian entrepreneurial minorities; Conjoint communities in the making of the world economy, 1570-1940. Richmond: Curzon Press, 1996, xiii + 246 pp. [Nordic Institute of Asian Studies Monograph Series 71.] - Ian Brown, Fukuda Shozo, With sweat and abacus; Economic roles of Southeast Asian Chinese on the eve of World War II, edited by George Hicks. Singapore: Select Books, 1995, xii + 246 pp. - Ian Brown, George Hicks, Chinese organisations in Southeast Asia in the 1930s. Singapore: Select Books, 1996, xv + 168 pp. - Matthew I. Cohen, Laurie J. Sears, Shadows of empire; Colonial discourse and Javanese tales. Durham/London: Duke University Press, 1996, xxi + 349 pp. - J. van Goor, Anthony Reid, Southeast Asia in the age of commerce 1450-1680. Vol. II: Expansion and crisis. New Haven/London: Yale University Press, 1993, xv + 390 pp. - J. van Goor, Anthony Reid, Southeast Asia in the age of commerce 1450-1680. Vol. I: The lands below the winds. New Haven/London: Yale University Press, 1988, xvi + 275 pp. - David Henley, Saya S. Shiraishi, Young heroes; The Indnesian family in politics. Ithaca/New York: Southeast Asia Program, Cornell University, Southeast Asia Program Publications, 1997, 183 pp. [Studies on Southeast Asia 22.] - Gerrit Knaap, P. Jobse, Bronnen betreffende de Midden-Molukken 1900-1942. Den Haag: Instituut voor Nederlandse Geschiedenis, 1997. 4 volumes. Rijks Geschiedkundige Publicatiën, Kleine Serie, 81, 82, 83, 84. Volume 1 bewerkt door P. Jobse, 2 en 3 door Ch.F. van Fraassen, 4 door Ch.F van Fraassen en P. Jobse. xii + 578, xii + 578, xii + 711, x + 655, xi + 261 pp., Ch. F. van Fraassen (eds. - Indro Nugroho-Heins, Clara Brakel-Papenhuyzen, Classical Javanese dance; The Surakarta tradition and its terminology. Leiden: KITLV Press, 1995, xi + 252 pp. [Verhandelingen 155.] - László Sluimers, Shigeru Sato, War, nationalism and peasants; Java under the Japanese occupation, 1942-1945. Armonk, New

Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease

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Tanaka R

2018-04-01

Full Text Available Rie Tanaka,1 Hisatoshi Sugiura,1 Mitsuhiro Yamada,1 Tomohiro Ichikawa,1 Akira Koarai,1 Naoya Fujino,1 Satoru Yanagisawa,1 Katsuhiro Onodera,1 Tadahisa Numakura,1 Kei Sato,1 Yorihiko Kyogoku,1 Hirohito Sano,1 Shun Yamanaka,1 Tatsuma Okazaki,1 Tsutomu Tamada,1 Motohiko Miura,2 Tsuneyuki Takahashi,3 Masakazu Ichinose1 1Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan; 2Department of Respiratory Medicine, Tohoku Rosai Hospital, Aoba-ku, Sendai, Japan; 3Department of Internal Medicine, Tohoku Medical and Pharmaceutical University Wakabayashi Hospital, Wakabayashi-ku, Sendai, Japan Background: Growth differentiation factor 11 (GDF11 is reported to possess anti-aging and rejuvenating effects, including muscle regeneration and to be highly expressed in skeletal muscle. Recently, we demonstrated that the levels of plasma GDF11 were decreased in COPD. However, the effect of decreased circulating GDF11 in the pathophysiology of COPD remains unknown. The aim of this study is to investigate the association between the plasma GDF11 levels and various clinical parameters in patients with COPD. Patients and methods: Eighteen ex-smokers as control subjects and 70 COPD patients participated in the current study. We measured the levels of plasma GDF11 using immunoblotting, lung function, physical activity using a triaxial accelerometer, quadriceps strength, exercise capacity, and systemic inflammatory markers. We investigated the association between the levels of plasma GDF11 and these clinical parameters. Results: The levels of plasma GDF11 in the COPD patients had significant positive correlations with the data of lung function. Furthermore, the levels of plasma GDF11 were significantly correlated with the physical activity, quadriceps strength, and exercise capacity. Moreover, the levels of plasma GDF11 were significantly correlated with the data of inflammatory markers. Although various factors were

Hydraulic/mechanical modeling of smectitic materials for HMC analytical evaluation of the long term performance of TRU geological repository - 59090

International Nuclear Information System (INIS)

Kobayashi, Ichizo; Owada, Hitoshi; Ishii, Tomoko

2012-01-01

injecting of water or exhausting of air due to compression. There will be, therefore, the possibility that the swelling deformation-pressure relation will be state functions and independent on the stress history. The fully-saturation line was compared with the equilibrium swelling pressure and dry density relation calculated from chemical potential by Sato (2008). Both were consistent with each other. It was found that the swelling behavior of smectitic materials can be treated as a state function in the mechanical analysis. (authors)

The pattern of eigenfrequencies of radial overtones which is predicted for a specified Earth-model

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E. R. LAPWOOD

1977-06-01

Full Text Available In 1974 Anderssen and Cleary examined the distribution of eigenfrequencies
of radial overtones in torsional oscillations of Earth-models.
They pointed out that according to Sturm-Liouville theory this distribution
should approach asymptotically, for large overtone number m,
the value nnz/y, where y is the time taken by a shear-wave to travel
along a radius from the core-mantle interface to the surface, provided
elastic parameters vary continuously along the radius. They found that,
for all the models which they considered, the distributions of eigenfrequencies
deviated from the asymptote by amounts which depended on
the existence and size of internal discontinuities. Lapwood (1975 showed
that such deviations were to be expected from Sturm-Liouville theory,
and McNabb, Anderssen and Lapwood (1976 extended Sturm-Liouville
theory to apply to differential equations with discontinuous coefficients.
Anderssen (1977 used their results to show how to predict the pattern
of deviations —called by McNabb et al. the solotone effect— for a
given discontinuity in an Earth-model.
Recently Sato and Lapwood (1977, in a series of papers which will
be referred to here simply as I, II, III, have explored the solotone effect
for layered spherical shells, using approximations derived from an exacttheory which holds for uniform layering. They have shown how the
form of the pattern of eigenfrequencies, which is the graph of
S — YMUJI/N — m against m, where ,„CJI is the frequency of the m"'
overtone in the I"' (Legendre mode of torsional oscillation, is determined
as to periodicity (or quasi-periodicity by the thicknesses and velocities
of the layers, and as to amplitude by the amounts of the discontinuities
(III. The pattern of eigenfrequencies proves to be extremely sensitive
to small changes in layer-thicknesses in a model.
In

PREFACE: 3rd International Symposium on Functional Materials 2009 (ISFM 2009) 3rd International Symposium on Functional Materials 2009 (ISFM 2009)

Science.gov (United States)

Kiwon, Kim; Li, Lu; Taehyun, Nam; Jouhyeon, Ahn

2010-05-01

The 3rd International Symposium on Functional Materials 2009 (ISFM 2009) and its preconference, Advances in Functional Materials 2009 (AFM 2009), were successfully held in the Republic of Korea from 15-18 June 2009 and in the People's Republic of China from 8-12 June 2009, respectively. The two conferences attracted over 300 oral and poster presentations from over 12 countries including Australia, Canada, China, Germany, Japan, India, Israel, Korea, The Netherlands, Thailand, the UK and the USA. In the two conferences, eight keynote lectures were delivered by S Miyazaki, S A Akbar, D J Singh, C Suryanarayana, M~Greenblatt, H Zhang, T Sato and J Ding. This topical issue of Physica Scripta contains papers presented at the ISFM 2009 and AFM 2009. Keyan Li from Dalian University, People's Republic of China, presents some empirical formulae to estimate the elastic moduli of rocksalt-, zincblende- and chalcopyrite-structured crystals, on the basis of electronegativities of bonded atoms in the crystallographic frame. Min-Jung Kim from Hanyang University, Korea, reports on the preparation and characterization of carboxyl functionalization of magnetite nanoparticles for oligonucleotide immobilization. F Yan from the National University of Singapore studies the fabrication of Bi(Fe0.5Sc0.5)O3-PbTiO3 (BSF-PT) thin films by pulsed laser deposition, and the enhanced magnetic moment with respect to BiFeO3-PbTiO3. Dong-Gil Lee from Pusan National University, Korea, reports on the sterilization of enteropathogenic Escherichia coli using nanofiber TiO2 films prepared by the electrostatic spray method. Sang-Eun Park from the Korea Institute of Science and Technology reports on the study of encapsulated Fe3O4 nanoparticles with a silica thin layer with a reversible capacity of about 363 mAhg-1. Other researchers report on many other exiting achievements in the fields of ferromagnetic materials, magneto-optical materials, thermoelectric materials, shape memory materials, fuel-cell and

Permeability Measurements of Rock Samples from Conduit Drilling at Unzen Volcano, Japan

Science.gov (United States)

Watanabe, T.; Shimizu, Y.; Noguchi, S.; Nakada, S.

2006-12-01

The last eruption of Unzen Volcano (1990-1995) was effusive to form lava domes, though magmas at depths are estimated to have contained volatile materials enough to cause explosive eruptions [e.g., Sato et al., 1995]. Most of volatile materials should have escaped from ascending magmas. The escape of gas is controlled by permeability of magmas and country rocks. Unzen Scientific Drilling Project sampled both the latest conduit and its country rock (USDP-4). In order to understand degassing processes, we have measured the permeability of these rock samples. Four cube samples with edges of 25 mm were cut from USDP-4 cores C1, C12 (country rock), C13 and C14 (conduit). Sample C1 is considered as Old Unzen Lava, and Sample C12 volcanic breccia. The transient pulse method was employed to measure the permeability. It applies a step of the fluid pressure difference across a specimen, and measures the decay rate of the fluid pressure difference. This method can be applied to samples with very low permeability, since it determines the permeability without measuring the fluid flux. Nitrogen gas was used as a pore fluid. Our permeametry system is built in a pressure vessel, and the confining pressure and the pore fluid pressure can be controlled independently. The temperature of the measurement system is kept constant within 0.1 degree. The temperature control and the background leak rate limit the measurable permeability to be higher than 10^{-20} m2. Measurements were first conducted under the atmospheric pressure. The permeability in a rock sample varies with the direction by a factor less than 5. Sample C1 has the lowest permeability (10^{-19} m2), and Sample C12 the highest value (10^{-17 m2). The permeability of C13 and C14 is of the order of 10^{- 18} m2. Though only a trace of vesicles can be seen in conduit samples, the interconnection is still maintained. The pressure dependence of the permeability is now investigated up to 50 MPa. The permeability of C13 and C14

High frequency equipment promotes antibacterial effects dependent on intensity and exposure time

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Wietzikoski Lovato EC

2018-03-01

Full Text Available Evellyn Claudia Wietzikoski Lovato,1 Patrícia Amaral Gurgel Velasquez,1 Cristiana dos Santos Oliveira,1 Camila Baruffi,1 Thais Anghinoni,1 Raquel Costa Machado,1 Francislaine Aparecida dos Reis Lívero,2 Samantha Wietzikoski Sato,1 Lisiane de Almeida Martins1 1Laboratory of Microbiology of Natural Products, Paranaense University, Umuarama, Brazil; 2Laboratory of Preclinical Research of Natural Products, Paranaense University, Umuarama, Brazil Background: The indiscriminate use of antibiotics has caused bacteria to develop mechanisms of resistance to antibacterial agents, limiting treatment options. Therefore, there is a great need for alternative methods to control infections, especially those related to skin. One of the alternative methods is the high frequency equipment (HFE, which is used on skin conditions as an analgesic, an anti-inflammatory, and mainly to accelerate cicatricial processes and have a bactericidal effect through the formation of ozone. This research investigated the antibacterial effect of HFE on standard cultures of bacteria.Materials and methods: Dilutions (104 colony forming unit mL−1 were performed for Enterobacter aerogenes and Staphylococcus aureus with 24-hour growth bacteria. Then, 1 μL of each dilution was pipetted into suitable medium and the HFE flashing technique was used at intensities of 6, 8 and 10 mA for 30, 60, 90, 120 and 180 seconds. The control group received no treatment. Plates were incubated at 37°C for 24 hours and then read.Results: The spark at intensity of 6 mA had no bactericidal effect on the E. aerogenes; however, a significant bacterial growth reduction occurred at intensity of 8 mA after 120 and 180 seconds, and at 10 mA, reduction in bacterial growth could already be verified at 30 seconds and total bacterial growth inhibition occurred in 180 seconds. For S. aureus, there was a strong bacterial growth inhibition at all intensities used; however, at 6 mA, absence of bacterium growth after

Prevalence and characteristics of asthma–COPD overlap syndrome identified by a stepwise approach

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Inoue H

2017-06-01

Full Text Available Hiromasa Inoue,1 Takahide Nagase,2 Satoshi Morita,3 Atsushi Yoshida,4 Tatsunori Jinnai,4 Masakazu Ichinose5 1Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, 2Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 3Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, 4Medical Department, AstraZeneca K.K., Osaka, 5Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan Background and objective: There is increasing recognition of asthma–COPD overlap syndrome (ACOS, which shares some features of both asthma and COPD; however, the prevalence and characteristics of ACOS are not well understood. The aim of this study was to investigate the prevalence of ACOS among patients with COPD and its characteristics using a stepwise approach as stated in the recent report of the Global Initiative for Asthma (GINA and the Global Initiative for Chronic Obstructive Lung Disease (GOLD. Methods: This multicenter, cross-sectional, observational study enrolled outpatients who were receiving medical treatment for COPD. Clinical data, including spirometry results, were retrieved from medical records. For symptom assessment, patients were asked to complete the Clinical COPD questionnaire and the modified British Medical Research Council questionnaire. Results: Of the 1,008 patients analyzed, 167 (16.6% had syndromic features of ACOS. Of the total number of patients, 93 and 42 (9.2% and 4.2% also had a predefined clinical variability of ≥12%/≥200 mL and ≥12%/≥400 mL in forced expiratory volume in 1 second (FEV1, respectively, and therefore were identified as having ACOS. Conversely, the number of patients who had either syndromic or spirometric feature of ACOS was 595 (59.0%, ≥12%/≥200 mL FEV1 clinical variability, and 328 patients (32.5%, ≥12%/≥400 m

Qualitative analysis of opinions, conditions and educational environment in relation to physical behaviour of adolescents Kvalitativní analýza názorů, podmínek a edukačního prostředí ve vztahu k pohybovému chování adolescentů

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Jiřina Janečková

2005-02-01

Full Text Available The aim of this study was to find and describe the possible causes of the interest, or lack of interest in adolescents in physical activity and physical education with use of qualitative analysis and to contribute to explication of other characteristics of physical behaviour. Further then to characterise "risky" behaviour of adolescents. Adolescents' opinions, the level of conditions and educational environment were gathered through semi-structured interviews and their following qualitative analysis with use of a paradigmatic model of axial coding of basic proven theory. Altogether 27 interviews with students from graduation classes were carried out following our four year long research project about physical activity. According to adolescents the principal cause of low level of physical activity is the lack of free time. School physical education is for most adolescents the only source of relatively intensive exercise. Favour of school physical education depends especially on the content of the lessons, the teacher's approach and the class team. Cílem této studie bylo užitím kvalitativní analýzy najít a popsat možné příčiny zájmu, resp. nezájmu adolescentů o pohybovou aktivitu a tělesnou výchovu a přispět k objasnění dalších charakteristik pohybového chování. Dále pak charakterizovat "rizikové" chování adolescentů. Názory adolescentů, úroveň podmínek a edukačního prostředí byly zjišťovány pomocí semi-strukturovaných rozhovorů a jejich následné kvalitativní analýzy užitím paradigmatického modelu axiálního kódování zakotvené teorie. Celkem bylo realizováno 27 rozhovorů se studenty maturitních ročníků v návaznosti na čtyřletý výzkum pohybové aktivity. Hlavní příčinou nízké úrovně pohybové aktivity je dle adolescentů nedostatek času. Školní tělesná výchova je pro většinu adolescentů jediným zdrojem intenzivnějšího pohybu. Obliba školní tělesné v

Immunization of rabbits with synthetic peptides derived from a highly conserved β-sheet epitope region underneath the receptor binding site of influenza A virus

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Ideno S

2013-11-01

Full Text Available Shoji Ideno,1,3 Kaoru Sakai,1 Mikihiro Yunoki,2–4 Ritsuko Kubota-Koketsu,3,5 Yuji Inoue,3 Shota Nakamura,6 Teruo Yasunaga,6 Yoshinobu Okuno,5 Kazuyoshi Ikuta3 1Infectious Pathogen Research Section, Central Research Laboratory, Research and Development Division, Japan Blood Products Organization, Kobe, Japan; 2Research and Development Promotion Section, Research and Development Division, Japan Blood Products Organization, Tokyo, Japan; 3Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan; 4Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan; 5Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kanonji, Kagawa, Japan; 6Department of Genome Informatics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan Background: There is increasing concern about the speed with which health care providers can administer prophylaxis and treatment in an influenza pandemic. Generally, it takes several months to manufacture an influenza vaccine by propagation of the virus in chicken eggs or cultured cells. Newer, faster protocols for the production of vaccines that induce broad-spectrum immunity are therefore highly desirable. We previously developed human monoclonal antibody B-1 that shows broadly neutralizing activity against influenza A virus H3N2. B-1 recognizes an epitope region that includes an antiparallel β-sheet structure underneath the receptor binding site of influenza hemagglutinin (HA. In this study, the efficacy of a synthetic peptide vaccine derived from this epitope region against influenza A was evaluated. Materials and methods: Two peptides were synthesized, the upper and lower peptides. These peptides comprise amino acid residues 167–187 and 225–241, respectively, of the B-1 epitope region of HA, which is involved in

國中教師以學習共同體啟動新學習型態之研究 Adopting a Learning Community in a Junior High School under the 12-Year Basic Education System

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薛雅慈（曉華） Ya-Ci (Hsiao-Hua Selena Hsueh

2014-03-01

of learning through a learning community, and numerous schools have participated in this learning community program. The traditional learning style of speaking while students listen is expected to change. In this qualitative study, student experiences and how they changed under the guidance of a learning community were investigated by conducting interviews, and potential problems in the learning method were identified. Five teachers from a junior high school, in which the learning community method was adopted in their classes, participated in this study. The results of positivist analysis indicate that the implementation of a learning community is expected to be a valuable educational method under the 12-Year Basic Education system. Both the researcher and the teachers observed changes in student learning caused by the use of various teaching strategies. Six crucial findings were derived from this research. (1 The methods used by junior high school teachers for promoting collaborative learning in their classes are comprehensive and diversified. (2 Based on the learning community proposed by Professor Manabu Sato, the most widely used method in practice among junior high school teachers is collaborative learning. (3 The collaborative learning technique used by junior high school teachers is typically cooperative learning, which focuses on group discussion and expression rather than on listening, connecting, and referring to the text, as argued by Sato. (4 Regarding junior high school students, the greatest benefit produced by collaborative learning is the cultivation of motivation and teamwork. (5 Inferior students who were previously unacquainted with their classmates attained achievements through collaborative learning. (6 Overall, the teachers enhanced student learning, and changed the learning style of the students in a positive manner.

Melting temperatures of MgO under high pressure determined by micro-texture observation

Science.gov (United States)

Kimura, T.; Ohfuji, H.; Nishi, M.; Irifune, T.

2016-12-01

for the peridotitic partial melt so that it is gravitationally stable to form the ULVZs at the bottom of the lower mantle. Reference 1 A. Zerr and R. Boehler, Nature 371, 506 (1994). 2 D. Alfe, Phys. Rev. Lett. 94, 235701 (2005). 3 N. de Koker and L. Stixrude, Geophys. J. Int. 178, 162 (2009). 4 Funamori, and N. Sato, Earth Planet. Sci. Lett. 295, 435 (2010).

Plasma levels of 3-methoxy-4-hydroxyphenylglycol are associated with microstructural changes within the cerebellum in the early stage of first-episode schizophrenia: a longitudinal VBM study

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Nishimura J

2014-12-01

Full Text Available Joji Nishimura,1 Shingo Kakeda,1 Osamu Abe,2 Reiji Yoshimura,3 Keita Watanabe,1 Naoki Goto,3 Hikaru Hori,3 Toru Sato,1 Hidemasa Takao,4 Hiroyuki Kabasawa,5 Jun Nakamura,3 Yukunori Korogi1 1Department of Radiology, University of Occupational and Environmental Health School of Medicine, Fukuoka, Japan; 2Department of Radiology, Graduate School of Medicine, Nihon University, Tokyo, Japan; 3Department of Psychiatry, University of Occupational and Environmental Health School of Medicine, Fukuoka, Japan; 4Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; 5MR Applied Science Laboratory Japan, GE Yokogawa Medical Systems, Hino-shi, Tokyo, Japan Abstract: The aims of this study are to determine how the interval changes of the brain structures in the early stage of first-episode schizophrenia relate to the interval changes in the clinical data, including the clinical symptoms of schizophrenia and catecholaminergic measures (plasma homovanillic acid [HVA] and 3-methoxy-4-hydroxyphenylglycol [MHPG]. Regional brain volumes and fractional anisotropy (FA/mean diffusivity (MD with diffusion tensor imaging (DTI were measured at baseline and 6-month follow-up in a 3T magnetic resonance imaging (MRI system in a cohort of 16 schizophrenic patients, who were in their first episode at the time of baseline MRI. At the time of baseline and follow-up MRI, all 16 patients underwent evaluations that included a psychopathological assessment (Positive and Negative Syndrome Scale [PANSS] and peripheral catecholaminergic measures (plasma MHPG or HVA. For interval changes between baseline and follow-up MRI data (morphological change, MD, and FA, the correlation/regression analysis was performed as a series of single regression correlations in Statistical Parametric Mapping 5, with the interval changes in PANSS or plasma HVA and MHPG as the covariates of interest. Positive and inverse correlations contrasts were created, and in this

Seismic velocity structure and spatial distribution of reflection intensity off the Boso Peninsula, Central Japan, revealed by an ocean bottom seismographic experiment

Science.gov (United States)

Kono, Akihiro; Sato, Toshinori; Shinohara, Masanao; Mochizuki, Kimihiro; Yamada, Tomoaki; Uehira, Kenji; Shinbo, Takashi; Machida, Yuuya; Hino, Ryota; Azuma, Ryosuke

2016-04-01

Off the Boso Peninsula, central Japan, where the Sagami Trough is in the south and the Japan Trench is in the east, there is a triple junction where the Pacific plate (PAC), the Philippine Sea plate (PHS) and the Honshu island arc (HIA) meet each other. In this region, the PAC subducts beneath the PHS and the HIA, and the PHS subducts beneath the HIA. Due to the subduction of 2 oceanic plates, numerous seismic events took place in the past. In order to understand these events, it is important to image structure of these plates. Hence, many researchers attempted to reveal the substructure from natural earthquakes and seismic experiments. Because most of the seismometers are placed inland area and the regular seismicity off Boso is inactive, it is difficult to reveal the precise substructure off Boso area using only natural earthquakes. Although several marine seismic experiments using active sources were conducted, vast area remains unclear off Boso Peninsula. In order to improve the situation, a marine seismic experiment, using airgun as an active source, was conducted from 30th July to 4th of August, 2009. The survey line has 216 km length and 20 Ocean Bottom Seismometers (OBSs) were placed on it. We estimated 2-D P-wave velocity structure from the airgun data using the PMDM (Progressive Model Development Method; Sato and Kenett, 2000) and the FAST (First Arrival Seismic Tomography ; Zelt and Barton, 1998). Furthermore, we identified the probable reflection phases from the data and estimated the location of reflectors using Travel time mapping method (Fujie et al. 2006). We found some reflection phases from the data, and the reflectors are located near the region where P-wave velocity is 5.0 km/s. We interpret that the reflectors indicate the plate boundary between the PHS and the HIA. The variation of the intensity of reflection along the upper surface of PHS seems to be consistent with the result from previous reflection seismic experiment conducted by Kimura et

Diagnosis of intestinal tuberculosis using a monoclonal antibody to Mycobacterium tuberculosis

Institute of Scientific and Technical Information of China (English)

Yasushi Ihama; Akira Hokama; Kenji Hibiya; Kazuto Kishimoto; Manabu Nakamoto; Tetsuo Hirata; Nagisa Kinjo

2012-01-01

AIM:To investigate the utility of immunohistochemical (IHC) staining with an antibody to Mycobacterium tuberculosis (M.tuberculosis) for the diagnosis of intestinal tuberculosis (TB).METHODS:We retrospectively identified 10 patients (4 males and 6 females; mean age =65.1 ± 13.6 years)with intestinal TB.Clinical characteristics,including age,gender,underlying disease,and symptoms were obtained.Chest radiograph and laboratory tests,including sputum Ziehl-Neelsen (ZN) staining,M.tuberculosis culture,and sputum polymerase chain reaction (PCR)for tubercle bacilli DNA,as well as Tuberculin skin test (TST) and QuantiFERON-TB gold test (QFT),were examined.Colonoscopic records recorded on the basis of Sato's classification were also reviewed,in addition to data from intestinal biopsies examined for histopathological findings,including hematoxylin and eosin staining,and ZN staining,as well as M.tuberculosis culture,and PCR for tubercle bacilli DNA.For the present study,archived formalin-fixed paraffin-embedded (FFPE) intestinal tissue samples were immunohistochemically stained using a commercially available species-specific monoclonal antibody to the 38-kDa antigen of the M.tuberculosis complex.These sections were also stained with the pan-macrophage marker CD68 antibody.RESULTS:From the clinical data,we found that no patients were immunocompromised,and that the main symptoms were diarrhea and weight loss.Three patients displayed active pulmonary TB,six patients (60％) had a positive TST,and 4 patients (40％) had a positive QFT.Colonoscopic findings revealed that all patients had type 1 findings (linear ulcers in a circumferential arrangement or linear ulcers arranged circumferentially with mucosa showing multiple nodules),all of which were located in the right hemicolon and/or terminal ileum.Seven patients (70％) had concomitant healed lesions in the ileocecal area.No acid-fast bacilli were detected with ZN staining of the intestinal tissue samples,and both M

Adaptation of the European Commission-recommended user testing method to patient medication information leaflets in Japan

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Yamamoto M

2017-06-01

Full Text Available Michiko Yamamoto,1 Hirohisa Doi,1 Ken Yamamoto,2 Kazuhiro Watanabe,2 Tsugumichi Sato,3 Machi Suka,4 Takeo Nakayama,5 Hiroki Sugimori6 1Department of Drug Informatics, Center for Education & Research on Clinical Pharmacy, Showa Pharmaceutical University, Tokyo, Japan; 2Department of Pharmacy Practice, Center for Education & Research on Clinical Pharmacy, Showa Pharmaceutical University, Tokyo, Japan; 3Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan; 4Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan; 5Department of Health Informatics, Kyoto University School of Public, Kyoto, Japan; 6Department of Preventive Medicine, Graduate School of Sports and Health Sciences, Daito Bunka University, Saitama, Japan Background: The safe use of drugs relies on providing accurate drug information to patients. In Japan, patient leaflets called Drug Guide for Patients are officially available; however, their utility has never been verified. This is the first attempt to improve Drug Guide for Patients via user testing in Japan.Purpose: To test and improve communication of drug information to minimize risk for patients via user testing of the current and revised versions of Drug Guide for Patients, and to demonstrate that this method is effective for improving Drug Guide for Patients in Japan.Method: We prepared current and revised versions of the Drug Guide for Patients and performed user testing via semi-structured interviews with consumers to compare these versions for two guides for Mercazole and Strattera. We evenly divided 54 participants into two groups with similar distributions of sex, age, and literacy level to test the differing versions of the Mercazole guide. Another group of 30 participants were divided evenly to test the versions of the Strattera guide. After completing user testing, the participants evaluated both guides in terms of amount of information

Three-dimensional FDTD Modeling of Earth-ionosphere Cavity Resonances

Science.gov (United States)

Yang, H.; Pasko, V. P.

2003-12-01

Resonance properties of the earth-ionosphere cavity were first predicted by W. O. Schumann in 1952 [Schumann, Z. Naturforsch. A, 7, 149, 1952]. Since then observations of extremely low frequency (ELF) signals in the frequency range 1-500 Hz have become a powerful tool for monitoring of global lightning activity and planetary scale variability of the lower ionosphere, as well as, in recent years, for location and remote sensing of sprites, jets and elves and associated lightning discharges [e.g., Sato et al., JASTP, 65, 607, 2003; Su et al., Nature, 423, 974, 2003; and references cited therein]. The simplicity and flexibility of finite difference time domain (FDTD) technique for finding first principles solutions of electromagnetic problems in a medium with arbitrary inhomogeneities and ever-increasing computer power make FDTD an excellent candidate to be the technique of the future in development of realistic numerical models of VLF/ELF propagation in Earth-ionosphere waveguide [Cummer, IEEE Trans. Antennas Propagat., 48, 1420, 2000], and several reports about successful application of the FDTD technique for solution of related problems have recently appeared in the literature [e.g., Thevenot et al., Ann. Telecommun., 54, 297, 1999; Cummer, 2000; Berenger, Ann. Telecommun., 57, 1059, 2002, Simpson and Taflove, IEEE Antennas Wireless Propagat. Lett., 1, 53, 2002]. In this talk we will present results from a new three-dimensional spherical FDTD model, which is designed for studies of ELF electromagnetic signals under 100 Hz in the earth-ionosphere cavity. The model accounts for a realistic latitudinal and longitudinal variation of ground conductivity (i.e., for the boundaries between oceans and continents) by employing a broadband surface impedance technique proposed in [Breggs et al., IEEE Trans. Antenna Propagat., 41, 118, 1993]. The realistic distributions of atmospheric/lower ionospheric conductivity are derived from the international reference ionosphere model

Treatment patterns, health care resource utilization, and costs in Japanese adults with attention-deficit hyperactivity disorder treated with atomoxetine

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Imagawa H

2018-02-01

Full Text Available Hideyuki Imagawa,1 Saurabh P Nagar,2 William Montgomery,3 Tomomi Nakamura,1 Masayo Sato,1 Keith L Davis2 1Medical Development Unit Japan, Eli Lilly Japan K.K., Kobe, Japan; 2RTI Health Solutions, Research Triangle Park, NC, USA; 3Global Patient Outcomes and Real World Evidence, Eli Lilly Australia, NSW, Australia Objective: To describe the characteristics and medication treatment patterns of adult patients with attention-deficit/hyperactivity disorder (ADHD prescribed atomoxetine in Japan. Materials and methods: A retrospective analysis of insurance claims data was conducted using the Japan Medical Data Center database. Adults (≥18 years with ADHD who had ≥1 atomoxetine claim from January 1, 2013 to December 31, 2014, and ≥180 to ≤900 days of follow-up were included. First atomoxetine claim defined the index date. Patient characteristics included age, gender, and comorbid conditions. Treatment patterns assessed included rates of atomoxetine discontinuation, switching, persistence, adherence (assessed via the medication possession ratio, and use of concomitant medications. Results: A total of 457 adults met all the inclusion criteria. Mean (SD age was 32.7 (10.4 years, and 61.0% of patients were male. Nearly 72.0% of the patients had at least one comorbid mental health condition in the baseline period; depression (43.8% and insomnia (40.7% were the most common mental health comorbidities. Most common physical comorbidities were chronic obstructive pulmonary disease (14.4% and diabetes (12.9%. Non-ADHD-specific psychotropics were prescribed to 59.7% of patients during the baseline period and to 65.9% during the follow-up period; 6.6% were prescribed non-ADHD-specific psychotropics concomitantly with atomoxetine. Overall, 40.0% of adults discontinued atomoxetine during the entire follow-up period and 65.9% were persistent with atomoxetine therapy at 3 months post-index date. Mean (SD atomoxetine medication possession ratio was 0.57 (0

Monitoring underground migration of sequestered CO2 using self-potential methods

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Ishido, T.; Pritchett, J.; Tosha, T.; Nishi, Y.; Nakanishi, S.

2013-12-01

known as a 'geobattery' (e.g. Sato & Mooney, Geophysics 1960; Bigalke & Grabner, Electrochimica Acta 1997): the metallic well casing acts as a vertical electronic conductor connecting regions of differing redox potential. Electrons flow upward though the casing from a deeper reducing environment to a shallower oxidizing environment, and simultaneously a compensating vertical flow of ions is induced in the surrounding formation to maintain charge neutrality. If the redox potential in the deeper region is then increased by injecting an oxidizing substance, the difference in redox potential between the shallower and deeper regions will be reduced, resulting in an SP increase near the wellhead. We will report the results of SP measurements during gas (CO2 or air) injection tests at various sites and numerical simulations carried out using the extended SP postprocessor, which incorporates the above 'geobattery' mechanism in addition to electrokinetic coupling, and discuss the possibility mentioned above more quantitatively.

Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model

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Sato T

2015-05-01

Full Text Available Toshimi Sato,1 Neil Alles,1,2 Masud Khan,1,3 Kenichi Nagano,1,4 Mariko Takahashi,1 Yukihiko Tamura,1 Asako Shimoda,5,6 Keiichi Ohya,1 Kazunari Akiyoshi,5,6 Kazuhiro Aoki1 1Department of Bio-Matrix (Pharmacology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; 2Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka; 3Department of Dental Pharmacology, City Dental College and Hospital, Dhaka, Bangladesh; 4Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA; 5Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, 6ERATO Akiyoshi Bio-Nanotransporter Project, Japan Science and Technology Agency, Katsura Int’tech Center Kyotodaigaku-Katsura, Nishikyo-ku, Kyoto, Japan Abstract: We investigated the biological activity of W9, a bone resorption inhibitor peptide, using NanoClik nanoparticles as an injectable carrier, where acryloyl group-modified cholesterol-bearing pullulan (CHPOA nanogels were crosslinked by pentaerythritol tetra (mercaptoethyl polyoxyethylene. Thirty 5-week-old male C57BL/6J mice were fed a low calcium diet and received once-daily subcutaneous injections of the carrier alone, W9 24 mg/kg/day alone, W9 24 mg/kg/day incorporated in cholesterol bearing pullulan (CHP nanogels, or W9 (8 and 24 mg/kg/day incorporated in NanoClik nanoparticles for 4 days (n=5. Mice that received a normal calcium diet with NanoClik nanoparticle injections without W9 were used as a control group. Radiological analyses showed that administration of W9 24 mg/kg/day significantly prevented low calcium-induced reduction of bone mineral density in the long bones and lumbar vertebrae, but only when the NanoClik nanoparticles were used as a carrier. Histomorphometric analyses of the proximal tibiae revealed that W9 24 mg/kg/day incorporated in NanoClik nanoparticles prevented the increase in bone resorption indices

Korelace mezi sportovní činností a užíváním návykových látek u 14letých žáků a žákyň základních škol ve Slovinsku Correlation between sport activity and drug-taking among 14 year-old primary school male and female pupils in Slovenia

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Jože Štihec

2006-02-01

Full Text Available Cílem tohoto průzkumu bylo zjistit, zda u 14letých žáků existuje korelace mezi sportovní aktivitou a užíváním návykových látek. Tento průzkum je založen na dotazníku s 38 proměnnými, přičemž pravděpodobnostní vztahy mezi proměnnými byly testovány pomocí chí-kvadrát testu. Analýza ukázala, že ve svém volném čase se sportu věnuje 80 % chlapců a 85 % dívek. Sportu se věnují většinou dvakrát až třikrát týdně. Většina chlapců se věnuje sportu závodně (39 %, zatímco dívky se věnují především rekreačním pohybovým aktivitám (48 %. Pokud jde o kouření, ke kuřákům patří 4 % procenta chlapců a 12 % dívek. Většina chlapců začala kouřit ve věku 13 let, dívky ve věku 12 let. 90 % chlapců a 94 % dívek již nějaký alkoholický nápoj vyzkoušelo – jde tedy o většinu žáků ve věku od 10 do 13 let. Pokud jde o užívání drog, vyzkoušelo je 18 % chlapců a 26 % dívek. Nejčastějšími typy drog jsou inhalace, pilulky a marihuana. Většina žáků prohlásila, že kouření, pití alkoholu a užívání nelegálních návykových látek vyzkoušela ze zvědavosti. Rodiče většinou podporují děti v provozování sportu. Většina žáků se domnívá, že sport a kouření spolu nejde dohromady. Domnívají se, že sportovní aktivity jsou činnosti, které by od užívání návykových látek mohly odrazovat. Zjistili jsme, že mezi sportovními aktivitami a užíváním legálních i nelegálních návykových látek není statisticky významná korelace. Statisticky významná korelace však byla zjištěna u pití alkoholu v případě chlapců (pivo a víno a inhalace látek v případě dívek. Rozdíly by zřejmě mohly být výraznější v pozdějším věku – při přechodu mezi základní a střední školou. Mladé lidi by bylo možno od užívání legálních i nelegálních návykových látek odradit nabídkou většího množství aktivit, kter

Stability range and decomposition of potassic richterite and phlogopite end members at 5-15 GPa

International Nuclear Information System (INIS)

Troennes, R.G.

2002-01-01

The phase relations of K-richterite, KNaCaMg 5 Si 8 O 22 (OH) 2 , and phlogopite, K 3 Mg 6 Al 2 Si O20 (OH) 2 , have been investigated at pressures of 5-15 GPa and temperatures of 1000-1500 o C. K-richterite is stable to about 1450 o C at 9-10 GPa, where the dp/dT-slope of the decomposition curve changes from positive to negative. At 1000 o C the alkali-rich, low-Al amphibole is stable to more than 14 GPa. Phlogopite has a more limited stability range with a maximum thermal stability limit of 1350 o C at 4-5 GPa and a pressure stability limit of 9-10 GPa at 1000 o C. The high-pressure decomposition reactions for both of the phases produce relatively small amounts of highly alkaline water-dominated fluids, in combination with mineral assemblages that are relatively close to the decomposing hydrous phase in bulk composition. In contrast, the incongruent melting of K-richterite and phlogopite in the 1-3 GPa range involves a larger proportion of hydrous silicate melts. The K-richterite breakdown produces high-Ca pyroxene and orthoenstatite or clinoenstatite at all pressures above 4 GPa. At higher pressures additional phases are: wadeite-structured K 2 Si VI Si IV 3 O 9 at 10 GPa and 1500 o C, wadeite-structured K 2 Si VI Si IV 3 O 9 and phase X at 15 GPa and 1500 o C, and stishovite at 15 GPa and 1100 o C. The solid breakdown phases of phlogopite are dominated by pyrope and forsterite. At 9-10 GPa and 1100-1400 o C phase X is an additional phase, partly accompanied by clinoenstatite close to the decomposition curve. Phase X has variable composition. In the KCMSH-system (K 2 CaMg 5 Si 8 O 22 (OH) 2 ) investigated by Inoue et al. (1998) and in the KMASH-system investigated in this report the compositions are approximately K 4 Mg 8 Si 8 O 25 (OH) 2 and K 3.7 Mg 7.4 Al 0.6 Si 8.0 O 25 (OH) 2 , respectively. Observations from natural compositions and from the phlogopite-diopside system indicate that phlogopite-clinopyroxene assemblages are stable along common geothermal

Proceedings of the 9th International Symposium on Foundations of Quantum Mechanics in the Light of New Technology

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Ishioka, Sachio; Fujikawa, Kazuo

2009-06-01

Committee -- Obituary: Professor Sadao Nakajima -- Opening address / H. Fukuyama -- Welcoming address / N. Osakabe -- Cold atoms and molecules. Pseudopotential method in cold atom research / C. N. Yang. Symmetry breaking in Bose-Einstein condensates / M. Ueda. Quantized vortices in atomic Bose-Einstein condensates / M. Tsubota. Quantum degenerate gases of Ytterbium atoms / S. Uetake ... [et al.]. Superfluid properties of an ultracold fermi gas in the BCS-BEC crossover region / Y. Ohashi, N. Fukushima. Fermionic superfluidity and the BEC-BCS crossover in ultracold atomic fermi gases / M. W. Zwierlein. Kibble-Zurek mechanism in magnetization of a spinor Bose-Einstein condensate / H. Saito, Y. Kawaguchi, M. Ueda. Quasiparticle inducing Josephson effect in a Bose-Einstein condensate / S. Tsuchiya, Y. Ohashi. Stability of superfluid fermi gases in optical lattices / Y. Yunomae ... [et al.]. Z[symbol] symmetry breaking in multi-band bosonic atoms confined by a two-dimensional harmonic potential / M. Sato, A. Tokuno -- Spin hall effect and anomalous hall effect. Recent advances in anomalous hall effect and spin hall effect / N. Nagaosa. Topological insulators and the quantum spin hall effect / C. L. Kane. Application of direct and inverse spin-hall effects: electric manipulation of spin relaxation and electric detection of spin currents / K. Ando, E. Saitoh. Novel current pumping mechanism by spin dynamics / A. Takeuchi, K. Hosono, G. Tatara. Quantum spin hall phase in bismuth ultrathin film / S. Murakami. Anomalous hall effect due to the vector chirality / K. Taguchi, G. Tatara. Spin current distributions and spin hall effect in nonlocal magnetic nanostructures / R. Sugano ... [et al.]. New boundary critical phenomenon at the metal-quantum spin hall insulator transition / H. Obuse. On scaling behaviors of anomalous hall conductivity in disordered ferromagnets studied with the coherent potential approximation / S. Onoda -- Magnetic domain wall dynamics and spin related

Blog Posting After Lung Cancer Notification: Content Analysis of Blogs Written by Patients or Their Families.

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Sato, Akira; Aramaki, Eiji; Shimamoto, Yumiko; Tanaka, Shiro; Kawakami, Koji

2015-05-18

anxiety in 495 sentences. Our results showed that there were substantially more posts concerning "Way of living, reasons for living, set of values" and "Relationships with medical staff (own hospital)" than in previous studies (Analysis B). This study provides insight into the feelings of dissatisfaction and anxieties held by lung cancer patients and their families, including those regarding the "Way of living, reasons for living, set of values" and "Relationship with medical staff (own hospital)," which were inaccessible in previous survey analyses. When comparing information obtained from patients' voluntary records and those from previous surveys conducted by health care institutions, it is likely that the former would be more indicative of patients' actual opinions and feelings. Therefore, it is important to utilize such records as an information resource. ©Akira Sato, Eiji Aramaki, Yumiko Shimamoto, Shiro Tanaka, Koji Kawakami. , 18.05.2015.

Re-examination of the original questionnaire documents for the 1944 Tonankai, 1945 Mikawa, and 1946 Nanaki earthquakes

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Harada, Tomoya; Satake, Kenji; Furumura, Takashi

2016-04-01

With the object of estimating seismic intensity, the Earthquakes Research Institute (ERI) of the University of Tokyo performed questionnaire surveys for the significant (destructive or large/great) earthquakes from 1943 to 1988 (Kayano, 1990, BERI). In these surveys, Kawasumi (1943)'s 12-class seismic intensity scale similar to the Modified Mercalli scale (MM-scale) was used. Survey results for earthquakes after 1950 were well investigated and published (e.g. Kayano and Komaki, 1977, BERI; Kayano and Sato, 1975, BERI), but the survey results for earthquakes in the 1940s have not been published and original documents of the surveys was missing. Recently, the original sheets of the surveys for the five earthquakes in the 1940s with more than 1,000 casualties were discovered in the ERI warehouse, although they are incomplete (Tsumura et al, 2010). They are from the 1943 Tottori (M 7.2), 1944 Tonankai (M 7.9), 1945 Mikawa (M 6.8), 1946 Nankai (M 8.0), and 1948 Fukui (M 7.1) earthquakes. In this study, we examined original questionnaire and summary sheets for the 1944 Tonankai, 1945 Mikawa, and 1946 Nanaki earthquakes, and estimated the distributions of seismic intensity, various kinds of damage, and human behaviors in detail. Numbers of the survey points for the 1944, 1945, and 1946 event are 287, 145, and 1,014, respectively. The numbers for the 1944 and 1945 earthquakes are much fewer than that of the 1946 event, because they occurred during the last years of World War II. The 1944 seismic intensities in the prefectures near the source region (Aichi, Mie, Shizuoka, and Gifu Pref.) tend to be high. However, the 1944 intensities are also high and damage is serious at the Suwa Lake shore in Nagano Pref. which is about 240 km far from the source region because seismic waves are amplified dramatically in the thick sediment in the Suwa Basin. Seismic intensities of the 1945 Mikawa earthquake near the source region in Aichi Pref. were very high (X-XI). However, the

PREFACE: 14th Latin American Workshop on Plasma Physics (LAWPP 2011)

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Bilbao, Luis; Minotti, Fernando; Kelly, Hector

2012-06-01

These proceedings present the written contributions from participants of the Latin American Workshop on Plasma Physics (LAWPP), which was held in Mar del Plata, Argentina, on 20-25 November 2011. This was the 14th session of the series of LAWPP biennial meetings, which started in 1982. The five-day scientific program of LAWPP 2011 consisted of 32 talks and various poster sessions, with the participation of 135 researchers from Argentina, Brazil, Canada, Chile, Colombia, Mexico, Puerto Rico, USA, Venezuela, as well as others from Europe and Asia. In addition, a School on Plasma Physics and a Workshop on Industrial Applications of Plasma Technology (AITP) were organized together with the main meeting. The five-day School held in the week previous to the meeting was intended for young scientists starting their research in Plasma Physics. On the other hand, the objective of the AITP Workshop was to enhance regional academic and industrial cooperation in the field of plasma assisted surface technology. Topics addressed at LAWPP 2011 included space plasmas, dusty plasmas, nuclear fusion, non-thermal plasmas, basic plasma processes, plasma simulation and industrial plasma applications. This variety of subjects is reflected in these proceedings, which the editors hope will result in enjoyable and fruitful reading for those interested in Plasma Physics. It is a pleasure to thank the Institutions that sponsored the meeting, as well as all the participants and collaborators for making this meeting possible. The Editors Luis Bilbao, Fernando Minotti and Hector Kelly LAWPP participants Participants of the 14th Latin American Workshop on Plasma Physics, 20-25 November 2011, Mar del Plata, Argentina International Scientific Committee Carlos Alejaldre, Spain María Virginia Alves, Brazil Ibere Caldas, Brazil Luis Felipe Delgado-Aparicio, Peru Mayo Villagrán, Mexico Kohnosuke Sato, Japan Héctor Kelly, Argentina Edberto Leal-Quirós, Puerto Rico George Morales, USA Julio Puerta

Effect of the nanoformulation of siRNA-lipid assemblies on their cellular uptake and immune stimulation

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Kubota K

2017-07-01

Full Text Available Kohei Kubota,1,2 Kohei Onishi,3 Kazuaki Sawaki,3 Tianshu Li,4 Kaoru Mitsuoka,5 Takaaki Sato,6 Shinji Takeoka1,3,4 1Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Sciences and Engineering, Waseda University (TWIns, Tokyo, Japan; 2Formulation Research and Phramaceutical Process Group, CMC R&D Center, Kyowa Hakko Kirin Co., Ltd, Shizuoka, Japan; 3Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering,Waseda University (TWIns, Tokyo, Japan; 4Research Organization for Nano and Life Innovation, Waseda University (TWIns, Tokyo, Japan; 5Research Center for Ultra-High Voltage Electron Microscopy, Osaka University, Osaka, Japan; 6Department of Chemistry and Materials, Faculty of Textile Science and Technology, Shinshu University, Nagano, Japan Abstract: Two lipid-based nanoformulations have been used to date in clinical studies: lipoplexes and lipid nanoparticles (LNPs. In this study, we prepared small interfering RNA (siRNA-loaded carriers using lipid components of the same composition to form molecular assemblies of differing structures, and evaluated the impact of structure on cellular uptake and immune stimulation. Lipoplexes are electrostatic complexes formed by mixing preformed cationic lipid liposomes with anionic siRNA in an aqueous environment, whereas LNPs are nanoparticles embedding siRNA prepared by mixing an alcoholic lipid solution with an aqueous siRNA solution in one step. Although the physicochemical properties of lipoplexes and LNPs were similar except for small increases in apparent size of lipoplexes and zeta potential of LNPs, siRNA uptake efficiency of LNPs was significantly higher than that of lipoplexes. Furthermore, in the case of LNPs, both siRNA and lipid were effectively incorporated into cells in a co-assembled state; however, in the case of lipoplexes, the amount of siRNA internalized into cells was small in comparison with lipid. siRNAs in

Thermal Demagnetization of Mare Basalts 10017 and 10020

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Suavet, C. R.; Weiss, B. P.; Grove, T. L.

2012-12-01

Paleomagnetic studies of lunar rocks 76535 (Garrick-Bethell et al., 2009), 10020 (Shea et al., 2012) and 10017 (Suavet et al., 2012) have shown that the Moon had an active dynamo field at 4.2 Ga, 3.7 Ga, and 3.6 Ga, respectively. These studies were carried out using alternating field (AF) demagnetization, which has the advantage to avoid sample alteration by heating, but the paleointensity is only constrained within a factor of 3-5 due to uncertainties on the calibration factor between thermoremanent magnetization (TRM) and anhysteretic remanent magnetization (ARM). Thermal demagnetization is expected to give better estimates of the paleofields. Thellier-Thellier paleointensity experiments on 10017 under reducing atmosphere (Sugiura et al., 1978) and in vacuum (Hoffman et al., 1979) were attempted in the past. Almost full demagnetization was observed after heating from 200 to 300°C, which was interpreted as alteration of magnetic carriers, or interaction effects between troilite and kamacite (Pearce et al., 1976). For both experiments, the oxygen fugacity was poorly constrained due to methodological flaws: no oxygen was introduced in the system and further reduction of the rocks could not be mitigated. We designed a controlled atmosphere apparatus to conduct thermal demagnetization in a mixture of H2 and CO2. Gas mixtures were calibrated by exploring the stability of iron, magnetite, and wustite at temperatures in the range of 300-800°C. We thermally demagnetized the natural remanent magnetization (NRM) of subsamples of 10017 and 10020 in a gas mixture with an oxygen fugacity ~1 log unit below the iron-wustite buffer (Sato et al., 1973). After heating from 200 to 250°C, the magnetization was reduced to 10% of the NRM for 10017, and 20% of the NRM for 10020, and the magnetization directions became unstable. A subsample of 10020 was given a 0.1 mT ARM, and thermally demagnetized up to 250°C: the magnetization was reduced to 38% of the ARM and the direction became

Stress-Induced Proton Disorder in Hydrous Ringwoodite

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Koch-Müller, M.; Rhede, D.; Mrosko, M.; Speziale, S.; Schade, U.

2008-12-01

observed up to 30 GPa without any discontinuity and their pressure behaviour (dν/dP) can well be described by linear fits. Molecular vibrations are very sensitive to non-hydrostatic conditions and we interpret the disappearance of the OH-bands as a stress-induced proton disordering in hydrous ringwoodite due to the use of hard pressure transmiting media like CsI or argon without thermal annealing. Thus, our study cannot confirm the phase transition observed by Camorro Perez et al. (2006) in ringwoodite. But as they used Neon as pressure transmitting medium, which is known to become non-hydrostatic at pressure above 16 GPa (Bell and Mao, 1981) we argue that their observation of a sudden disappearance of the OH band may also be related to non-hydrostatic conditions. References Bell P.M. and Mao H.-K. (1981) Carnegie Inst. Wash Yrbk 80: 404-406. Camorro Perez E.M., Daniel I., Chervin J.-C., Dumas P., Bass J.D. and Inoue T. (2006) Phys. Chem. Minerals, 33, 502 - 510. Kudoh Y., Kuribayashi T., Mizohata H., Ohtani E., (2000) Phys. Chem. Mineral. 27, 474-479. Wittlinger J., Fischer R., Wener S., ScheiderJ., Schulz J. (1997) Acta Cryst B53, 745 - 749.

Tratamento do tromboembolismo pulmonar maciço por fragmentação percutânea do trombo Treatment of massive pulmonary embolism by percutaneous fragmentation of the thrombus

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Marco Antonio Oliveira Barbosa

2007-03-01

Full Text Available OBJETIVOS: Avaliar a segurança e a eficácia da fragmentação percutânea do trombo (FPT no tromboembolismo pulmonar (TEP maciço em pacientes com contra-indicação à administração de trombolíticos. MÉTODOS: Entre julho de 1999 e agosto de 2005, 10 pacientes (7 homens, 3 mulheres, idade média de 57±18 anos com TEP maciço e contra-indicação à administração de trombolíticos foram submetidos a FPT. A saturação arterial de oxigênio (Sat.O2, índice de Walsh (IW, pressão arterial pulmonar média (PAP, pressão arterial sistêmica média (PAS e função ventricular direita (FVD ao ecocardiograma Doppler transtorácico foram avaliados pré e pós-procedimento. Foi realizada análise estatística por meio do teste de Wilcoxon pareado, sendo p significativo quando OBJECTIVES: To evaluate the safety and efficacy of percutaneous thrombus fragmentation (PTF for massive pulmonary embolism (PE in patients with contraindications to the administration of thrombolytics. METHODS: Between July 1999 and August 2005, 10 patients (7 males, 3 females, age 57±18 years with massive PE and contraindications to the administration of thrombolytics underwent PTF. A transthoracic doppler echocardiogram was used to evaluate arterial oxygen saturation (Sat O2, the Walsh index (WI, mean pulmonary artery pressure (PAP, mean systemic blood pressure (SBP and right ventricular function (RVF before and after the procedure. Statistical analysis was conducted using the paired Wilcoxon test, of which p was significant when < 0.05. RESULTS: After the PTF treatment there was an improvement in Sat. O2 [87.4 ± 1.3% vs 92.3 ± 3.1% (p < 0.001], WI [6.4 ± 1.07 vs 4.4 ± 1.42 (p = 0.003], PAP [31.8 ± 4.6 mmHg vs 25.5 ± 3.4 mmHg (p < 0.001] and SBP [73.9 ± 8.7 vs 85 ± 8.3 (p = 0.001. The ten patients had severe RVF before the percutaneous treatment; however, within 10 days after PTF, 8 presented normal or discrete function and 1 presented mitigated function. There

Kanto Asperity Project -Background and Outline-

Science.gov (United States)

Kobayashi, R.; Yamamoto, Y.; Sato, T.; Shishikura, M.; Curewitz, D.

2009-12-01

The Kanto region (Tokyo and the surrounding area) is one of the most densely populated urban areas in the world and has been devastated by repeated great earthquakes. This region is located at an island arc-island arc collision zone and a zone where Pacific and Philippine Sea plates are subducting. Great earthquakes along the Sagami trough, where the Philippine Sea slab is subducting, have repeatedly occurred. The 1703 Genroku and 1923 (Taisho) Kanto earthquakes caused severe damages in the metropolitan area. The recurrence periods of Taisho- and Genroku-type earthquakes are about 200-400 and 2000 years, respectively (e.g., Earthquake Research Committee, 2004). Many studies on the asperities along the Sagami trough have been carried out. Two asperities of the 1923 Kanto earthquake are located around the western part of Kanagawa prefecture (the base of the Izu peninsula) and around the Miura peninsula. An additional asperity of the 1703 Genroku earthquake is located the southern part of the Boso Peninsula. Slow slip events have also repeatedly occurred in an area adjacent to the asperities of the great earthquakes, off Boso peninsula (e.g., Ozawa et al 2007). In the cases of Nankai and Cascadia, slow slip events occur at deeper levels than the asperities, in a transition zone between the asperity and a region of steady slip. In contrast, slow slip events in the Kanto region have occurred at relatively shallow depths, at the same level as the asperity, raising the possibiltiy of friction controlled by different conditions (materials, fluid, or surface roughness) to those (temperature and pressure) encountered at Nankai and Cascadia. Deep seismic profiling have been carried out since the Special Project for Earthquake Disaster Mitigation in Urban areas (DaiDaiToku) (2002-2006). These profiling successfully presented a new image of the upper surface of the Philippine Sea slab (Sato et al. 2005), which is shallower than the previous models. This profiling also presents

Heterogeneous Structure and Seismicity beneath the Tokyo Metropolitan Area

Science.gov (United States)

Nakagawa, S.; Kato, A.; Sakai, S.; Nanjo, K.; Panayotopoulos, Y.; Kurashimo, E.; Obara, K.; Kasahara, K.; Aketagawa, T.; Kimura, H.; Hirata, N.

2010-12-01

Beneath the Tokyo metropolitan area, the Philippine Sea Plate (PSP) subducts and causes damaged mega-thrust earthquakes. Sato et al. (2005) revealed the geometry of upper surface of PSP, and Hagiwara et al. (2006) estimated the velocity structure beneath Boso peninsula. However, these results are not sufficient for the assessment of the entire picture of the seismic hazards beneath the Tokyo metropolitan area including those due to an intra-slab M7+ earthquake. So, we launched the Special Project for Earthquake Disaster Mitigation in the Tokyo Metropolitan area (Hirata et al., 2009). Proving the more detailed geometry and physical properties (e.g. velocities, densities, attenuation) and stress field within PSP is very important to attain this issue. The core item of this project is a dense seismic array called Metropolitan Seismic Observation network (MeSO-net) for making observations in the metropolitan area (Sakai and Hirata, 2009; Kasahara et al., 2009). We deployed the 249 seismic stations with a spacing of 5 km. Some parts of stations construct 5 linear arrays at interval of 2 km such as Tsukuba-Fujisawa (TF) array, etc. The TF array runs from northeast to southwest through the center of Tokyo. In this study, we applied the tomography method to image the heterogeneous structure under the Tokyo metropolitan area. We selected events from the Japan Meteorological Agency (JMA) unified earthquake list. All data of MeSO-net were edited into event data by the selected JMA unified earthquake list. We picked the P and S wave arrival times. The total number of stations and events are 421 and 1,256, respectively. Then, we applied the double-difference tomography method (Zhang and Thurber, 2003) to this dataset and estimated the fine-scale velocity structure. The grid nodes locate 10 km interval in parallel with the array, 20 km interval in perpendicular to the array; and on depth direction, 5 km interval to a depth of less than 50 km and 10 km interval at a depth of more

Development of backward equations T(p,h), T(p,s) and p(h,s) for heavy water liquid and vapor

International Nuclear Information System (INIS)

Nick P Petropoulos; Simos E Simopoulos

2005-01-01

equations can be used for the calculation of very accurate starting values. Charts included in this work comprehensively present the absolute deviations of heavy water temperatures and pressures calculated using the developed functions from the temperatures and pressures calculated iteratively from the heavy water equations of state. Use of all three developed equations should be explicitly limited within their validity range provided for liquid and steam. References: [1] 'The IAPS Formulation 1984 for the Thermodynamic Properties of Heavy Water Substance', The 10. International Conference on the Properties of Steam, Moscow, USSR, 1984. [2] Wagner W., Cooper J.R., Dittmann A., Kijima J., Kretzschmar H.-J., Kruse A., Mares R., Oguchi K., Sato H., Stoecker I, Sifner O, Takaishi Y., Tanishita I., Truebenbach J., Willkommen Th., 'The IAPWS Industrial Formulation 1997 for the Thermodynamic Properties of Water and Steam', Transactions of the ASME, Journal of Engineering for Gas Turbines and Power, 122:150-182, 2000. (authors)

EDITORIAL: Proceedings of the Sixth Edoardo Amaldi Conference on Gravitational Waves

Science.gov (United States)

Mio, N.

2006-03-01

Journal of Physics: Conference Series and the other is a special issue of Classical and Quantum Gravity (CQG), presenting the highlights of the conference. This is the first time this format has been used and selecting the highlights for CQG was a difficult task as the quality of the papers submitted was so high. The issue has been published thanks to the excellent work of the reviewers who gave precise and appropriate comments to the Editors. We strongly believe this issue to be a milestone in the inception of GW astronomy. The conference organizers would like to acknowledge the financial support of IUPAP, Okinawa prefecture, Inoue Foundation for Science, The Foundation for Promotion of Astronomy and a Grant-in-Aid for Scientific Research on Priority Areas (415) of the Ministry of Education, Culture, Sports, Science and Technology. The conference scientific programme was organized with the help of the session conveners. Their collaboration was indispensable for the success of the conference. We also appreciate the members of the international advisory committee and the local organizing committee; in particular, we thank Dr Akiteru Takamori for designing the fascinating poster of the conference and the image for the CD of this issue. The miscellaneous duties that were necessary for the conference were carried out with the help of ICS Convention Design Inc. with special thanks due to Ms Makiko Uwato and Mr Hiroyuki Suzuki. The proceedings are published by Institute of Physics Publishing; we would like to express our deep appreciation to Ms Judith Adams for her efficient management of the proceedings. Finally, we thank all of the excellent participants who made the conference so successful.

EDITORIAL: Proceedings of the 6th Edoardo Amaldi Conference on Gravitational Waves, Bankoku Shinryoukan, Okinawa, Japan, 20-24 June 2005 Proceedings of the 6th Edoardo Amaldi Conference on Gravitational Waves, Bankoku Shinryoukan, Okinawa, Japan, 20-24 June 2005

Science.gov (United States)

Mio, N.

2006-04-01

Journal of Physics: Conference Series and the other is a special issue of Classical and Quantum Gravity (CQG), presenting the highlights of the conference. This is the first time this format has been used and selecting the highlights for CQG was a difficult task as the quality of the papers submitted was so high. The issue has been published thanks to the excellent work of the reviewers who gave precise and appropriate comments to the Editors. We strongly believe this issue to be a milestone in the inception of GW astronomy. The conference organizers would like to acknowledge the financial support of IUPAP, Okinawa prefecture, Inoue Foundation for Science, The Foundation for Promotion of Astronomy and a Grant-in-Aid for Scientific Research on Priority Areas (415) of the Ministry of Education, Culture, Sports, Science and Technology. The conference scientific programme was organized with the help of the session conveners. Their collaboration was indispensable for the success of the conference. We also appreciate the members of the international advisory committee and the local organizing committee; in particular, we thank Dr Akiteru Takamori for designing the fascinating poster of the conference and the image for the cover of this issue. The miscellaneous duties that were necessary for the conference were carried out with the help of ICS Convention Design Inc. with special thanks due to Ms Makiko Uwato and Mr Hiroyuki Suzuki. The proceedings are published by Institute of Physics Publishing; we would like to express our deep appreciation to Ms Judith Adams for her efficient management of the proceedings. Finally, we thank all of the excellent participants who made the conference so successful.

Necrose isquêmica hepática e diabete melito: relato de caso Liver ischemic necrosis and diabetes mellitus: case report

Directory of Open Access Journals (Sweden)

Ticiana Paes

2007-12-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: O infarto hepático é definido como necrose isquêmica do parênquima hepático envolvendo pelo menos dois ácinos. Trata-se de evento considerado raro devido ao duplo suprimento sangüíneo, arterial e venoso. O objetivo deste estudo foi relatar um caso de paciente não sabidamente diabética que desenvolveu extensas áreas isquêmicas de infarto hepático, após quadro de descompensação aguda da diabete. RELATO DO CASO: Paciente do sexo feminino, 67 anos, hipertensa, procurou o Pronto Socorro com queixas de polidipsia, poliúria, turvação visual, náuseas e vômitos, dificuldade para deambular, havia aproximadamente 10 dias. Ao exame físico foi observado desidratação, palidez cutânea, cianose periférica, hipotermia, taquicardia, hipotensão, dor abdominal leve e difusa. Exames laboratoriais mostraram: leucócitos: 16800, creatinina (Cr: 3,7, uréia (Ur: 167, Na: 133, K: 6.9, glicose: 561; gasometria arterial (cateter de oxigênio: 2 L/min: pH: 6.93, pCO2: 12.1, pO2: 107, BE: -28,8, HCO3: 2,4, Sat 91,3%, lact: 79; urina I: pH: 6,0; leucócitos: 13; densidade: 1015; eritrócitos: 19; proteína: ++; glicose: +++; bilirrubina: negativa; corpos cetônicos: + denotando cetonemia. Eletrocardiograma com onda T apiculada, bloqueio de ramo direito. A paciente foi tratada com insulina, hidratação, bicarbonato de sódio e introduzido antibioticoterapia. Após o tratamento inicial, os exames laboratoriais mostraram: Cr: 2,2, Ur: 122, Na: 162, K: 4,3, Ca: 6,4, glicose: 504, pH: 7,01, HCO3: 7.1, BE: - 22. Um dia após, a paciente apresentou importante dor abdominal acompanhada de irritação peritoneal, além de sonolência e dificuldade para falar; exames laboratoriais mostraram: pH: 7,4, pCO2 : 31, pO2: 68, BE: -4,4, HCO3: 19, Sat.O2: 93,5%; Ur: 95; Cr: 1,4, albumina: 2,4, Ca: 0,95, Na: 166, K:4, bilirrubina: 0,5, bilirrubina D/I: 0,2/0,3, amilase: 1157, Gama-GT: 56, AST 7.210, ALT: 2.470, VHS: 15, lipase: 84

Duševní stav málo a pravidelně tělesně aktivních žen ve druhém trimestru těhotenství The state of mind of less physically active and regularly physically active women in the second trimester of their pregnancies

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Damir Karpljuk

2008-04-01

ětluje 23,51 % variance z celkových 34,91 % vysvětlené variance. Těhotné ženy skupiny PTA tedy svůj stav defi novaly většinou jako pozitivní, s následujícími emocemi: uvolněný, spokojený, příjemný, nepesimistický, přitažlivý, hrdý a šťastný. U skupiny NTA byl prvním eliminovaným faktorem faktor spojený s negativními emocemi, což vysvětluje 19,45 % variance z celkových 34,68 % vysvětlené variance. Tato skupina těhotných žen defi novala svůj stav většinou jako negativní, s následujícími opakujícími se emocemi: melancholický, napjatý, vznětlivý, depresivní a nervózní. Zjištěná fakta ukazují, že pravidelná sportovní aktivita prospívá duševnímu stavu a duševnímu zdraví těhotných žen. The moment a woman fi nds out that she is pregnant, her life changes in many aspects as she starts to adjust to the baby growing in her body. Her wish is to feel well, to safely reach the due date and give birth to a healthy child. We conducted a survey among 163 pregnant women at the end of the second trimester of their pregnancies and this article presents the relationship between their sport activity and their state of mind during pregnancy. Two groups of pregnant women, namely those who were regularly physically active (RPA and those with a low level of being physically active (LPA were compared and the relationship between their level of sport activity and their state of mind was established. The first part of the inventory focused on sport activity, namely – the frequency, forms and types of their sport activities. The RPA group consisted of 69 pregnant women who regularly engage in organised sport activities at sport centres or are physically active 3 to 4 times a week in an unorganised way. Activities which lasted for 30 minutes or more were considered. The LPA group consisted of 94 pregnant women who were physically active only occasionally or were physically inactive. The second part of the inventory investigating

iB1350 no.1. A generation III.7 reactor after the Fukushima Daiichi accident

International Nuclear Information System (INIS)

Sato, Takashi; Matsumoto, Keiji; Hosomi, Kenji; Kojima, Yoshihiro; Taguchi, Keisuke

2017-01-01

iB1350 stands for an innovative, intelligent and inexpensive BWR 1350. It is the first generation III.7 reactor after the Fukushima Daiichi accident. It has incorporated lessons learned from the Fukushima Daiichi accident and WENRA safety objectives. It has innovative safety to cope with devastating natural disasters including a giant earthquake, a large tsunami and a monster hurricane. The iB1350 can survive passively such devastation and a very prolonged SBO without any support from the outside of a site up to 7 days even preventing core melt. It, however, is based on the well-established proven ABWR design. The NSSS is exactly the same as that of the current ABWR. As for safety design, it has a double cylinder RCCV (Mark W containment) and in-depth hybrid safety systems (IDHS). The Mark W containment has double FP confinement barriers and the in-containment filtered venting system (IFVS) that enable passively no emergency evacuation outside the immediate vicinity of the plant for a SA. It has a large volume to hold hydrogen, an innovative core catcher (iCC), a passive flooding system and an innovative passive containment cooling system (iPCCS) establishing passively practical elimination of containment failure even in a long term. The IDHS consists of 4 division active safety systems for a DBA, 2 division active safety systems for a SA and built-in passive safety systems (BiPSS) consisting of an isolation condenser (IC) and the iPCCS for a SA. While the conventional PCCS can never cool the S/P, the iPCCS can automatically cool the S/P directly even in a DBA LOCA. That makes it possible for the iB1350 to optimize the active safety systems for a DBA. Sato came up with several optimized configurations of the IDHS that are expected to achieve further cost reduction and enhance its reliability resulting from passive feature of the iPCCS. The IC/iPCCS pool has enough capacity for 7 day grace period. The IC/iPCCS heat exchangers, the core and the spent fuel pool are

Climate forcing growth rates: doubling down on our Faustian bargain

Science.gov (United States)

Hansen, James; Kharecha, Pushker; Sato, Makiko

2013-03-01

vapor. The Alternative Scenario, defined in detail by Hansen and Sato (2004), keeps maximum global warming at ~1.5 °C relative to 1880-1920, under the assumption that fast-feedback climate sensitivity is ~3 °C for doubled CO2 (Hansen et al 2007). The Alternative Scenario allows CO2 to reach 475 ppm in 2100 before declining slowly; this scenario assumes that reductions of non-CO2 greenhouse gases and black carbon aerosols can be achieved sufficient to balance the warming effect of likely future decreases of reflective aerosols. Figure 4. Figure 4. Observed atmospheric CH4 amount and scenarios for twenty first century. Alternative scenario (Hansen et al 2000, Hansen and Sato 2004) yields maximum global warming ~1.5 °C above 1880-1920. Other scenarios are from IPCC (2001). Forcing on right hand scale is adjusted forcing, Fa, relative to values in 2000 (Hansen et al 2007). There are anthropogenic sources of CH4 that potentially could be reduced, indeed, the leveling off of CH4 amount during the past 20 years seems to have been caused by decreased venting in oil fields (Simpson et al 2012), but the feasibility of overall CH4 reduction also depends on limiting global warming itself, because of the potential for amplifying climate-CH4 feedbacks (Archer et al 2009, Koven et al 2011). Furthermore, reduction of atmospheric CH4 might become problematic if unconventional mining of gas, such as 'hydro-fracking', expands widely (Cipolla 2009), as discussed further below. The growth rate for the total climate forcing by well-mixed greenhouse gases has remained below the peak values reached in the 1970s and early 1980s, has been relatively stable for about 20 years, and is falling below IPCC (2001) scenarios (figure 5). However, the greenhouse gas forcing is growing faster than in the Alternative Scenario. MPTGs and OTGs in figure 5 are Montreal Protocol Trace Gases and Other Trace Gases (Hansen and Sato 2004). Figure 5. Figure 5. Five-year mean of the growth rate of climate forcing

Efeitos cardiorrespiratórios da buprenorfina em cães anestesiados pelo desfluorano Cardiorespiratory effects of buprenorphine in dogs anesthetized with desflurane

Directory of Open Access Journals (Sweden)

Almir Pereira de Souza

2005-12-01

Full Text Available Objetivou-se, com este estudo, avaliar os efeitos da buprenorfina sobre variáveis cardiovasculares e respiratórias em cães durante anestesia com desfluorano. Para tanto, foram utilizados 20 cães adultos, distribuídos em dois grupos (GB e GC. A anestesia foi induzida com propofol (8mg kg-1 IV e em seguida os animais foram intubados com sonda de Magill, a qual foi conectada ao aparelho de anestesia para administração de desfluorano (1,5 CAM. Após 30 minutos, foi aplicado no GB buprenorfina (0,02mg kg-1 e no GC solução de NaCl à 0,9% (0,05ml kg-1. Avaliaram-se: freqüências cardíaca e respiratória (FC e ¦; pressões arteriais sistólica, diastólica e média (PAS, PAD e PAM; débito cardíaco (DC; pressão venosa central (PVC; e as variáveis hemogasométricas pH, PaCO2, PaO2, HCO3, SatO2 e DB. As colheitas dos dados foram feitas aos 30 minutos após o início da administração do desfluorano (MO, 15 minutos após a administração do opióide ou placebo (M15, e a cada 15 minutos após Ml5 (M30, M45, M60 e M75. A avaliação estatística dos dados foi efetuada por meio de Análise de Perfil (P¦ e o pH tiveram reduções no GB, enquanto a PaCO2 esteve aumentada. Concluiu-se que a inclusão da buprenorfina durante anestesia inalatória pelo desfluorano determina discretas alterações cardiovasculares, bem-como potencializa a hipoventilação promovida pelo desfluorano, com a manifestação de hipercapnia, o que não contra-indica o seu uso em pacientes estáveis.The aim of this study was to evaluate the effects of buprenorphine on cardiovascular and respiratory variables in dogs anesthetized with desflurane. Twenty adult healthy male and female mongrel dogs were randomly distributed in two groups of ten animals each (GB and GC. The anesthetic induction was done using propofol (8mg kg-1, IV, and immediately, the dogs were intubated and submited to desflurane anesthesia administrated at 1.5 MAC. After 30 minutes of induction, animals

PREFACE: Ultrafast and nonlinear optics in carbon nanomaterials

Science.gov (United States)

Kono, Junichiro

2013-02-01

Journal of Physics: Condensed Matter staff for their help, patience and professionalism. Since this is a fast-moving field, there is absolutely no way of presenting definitive answers to all open questions, but we hope that this special section will provide an overview of the current state of knowledge regarding this topic. Furthermore, we hope that the exciting science and technology described in this section will attract and inspire other researchers and students working in related fields to enter into the study of ultrafast and nonlinear optical phenomena in carbon-based nanostructures. Ultrafast and nonlinear optics in carbon nanomaterials contents Ultrafast and nonlinear optics in carbon nanomaterialsJunichiro Kono The impact of pump fluence on carrier relaxation dynamics in optically excited grapheneT Winzer and E Malic Time-resolved spectroscopy on epitaxial graphene in the infrared spectral range: relaxation dynamics and saturation behaviorS Winnerl, F Göttfert, M Mittendorff, H Schneider, M Helm, T Winzer, E Malic, A Knorr, M Orlita, M Potemski, M Sprinkle, C Berger and W A de Heer Nonlinear optics of graphene in a strong magnetic fieldXianghan Yao and Alexey Belyanin Theory of coherent phonons in carbon nanotubes and graphene nanoribbonsG D Sanders, A R T Nugraha, K Sato, J-H Kim3, J Kono3, R Saito and C J Stanton Non-perturbative effects of laser illumination on the electrical properties of graphene nanoribbons Hernán L Calvo, Pablo M Perez-Piskunow, Horacio M Pastawski, Stephan Roche and Luis E F Foa Torres Transient absorption microscopy studies of energy relaxation in graphene oxide thin film Sean Murphy and Libai Huang Femtosecond dynamics of exciton localization: self-trapping from the small to the large polaron limit F X Morrissey, J G Mance, A D Van Pelt and S L Dexheimer

Long-period Ground Motion Characteristics Inside and Outside of the Osaka Basin during the 2011 Great Tohoku Earthquake and Its Largest Aftershock

Science.gov (United States)

Sato, K.; Iwata, T.; Asano, K.; Kubo, H.; Aoi, S.

2013-12-01

The 2011 great Tohoku earthquake (Mw 9.0) occurred on March 11, 2011, and the largest aftershock (Mw 7.7) at the region adjacent to south boundary of the mainshock's source region. Long-period ground motions (1-10s) of large amplitude were observed in the Osaka sedimentary basin about 550-800km away from the source regions during both events. We studied propagation and site characteristics of these ground motions, and found some common features between these two events in the Osaka basin. (1) The amplitude of horizontal components of the ground motion at the site-specific period is amplified at each sedimentary station. The predominant period is around 7s in the bayside area where the largest pSv were observed. (2) The velocity Fourier spectra have their peak values around 7s at the bedrock sites surrounding the Osaka basin. (3) Two remarkable wave packets separated by 30s propagating from stations around the Nobi plain to the bedrock sites near the Osaka basin were seen in the pasted-up velocity waveforms from the source regions to the Osaka basin for both events (Sato et al., 2012). Therefore, large long-period ground motions in the Osaka basin are generated by the combination of propagation-path and basin effects. Firstly, we simulate ground motions due to the largest aftershock using three-dimensional FDM (GMS; Aoi and Fujiwara, 1999). The reason we focus on the largest aftershock is that this event has a relatively small rupture area and simple rupture process compared to the mainshock. The source model is based on the model estimated by Kubo et al. (2013). The velocity structure model is a three-dimensional velocity structure based on the Japan Integrated Velocity Structure Model (Koketsu et al., 2012) and the layer of Vs 350m/s in this model is replaced with one of Vs 500m/s. The minimum effective period in this computation is 3s. Then, we compare synthetic waveforms with observed ones. At CHBH14, the nearest station to the source and 60km away from the

Cognitive and Behavioral Skills Exercises Completed by Patients with Major Depression During Smartphone Cognitive Behavioral Therapy: Secondary Analysis of a Randomized Controlled Trial.

Science.gov (United States)

Furukawa, Toshi A; Horikoshi, Masaru; Fujita, Hirokazu; Tsujino, Naohisa; Jinnin, Ran; Kako, Yuki; Ogawa, Sei; Sato, Hirotoshi; Kitagawa, Nobuki; Shinagawa, Yoshihiro; Ikeda, Yoshio; Imai, Hissei; Tajika, Aran; Ogawa, Yusuke; Akechi, Tatsuo; Yamada, Mitsuhiko; Shimodera, Shinji; Watanabe, Norio; Inagaki, Masatoshi; Hasegawa, Akio

2018-01-11

tasks, engaged in different types of activities, and also filled in more cognitive restructuring worksheets than the latter. Activities such as "test-drive a new car," "go to a coffee shop after lunch," or "call up an old friend" were found to be particularly rewarding. All cognitive restructuring strategies were found to significantly decrease the distress level, with "What would be your advice to a friend who has a similar problem?" found more helpful than some other strategies. The CBT program offered via smartphone and connected to the remote server is not only effective in alleviating depression but also opens a new avenue in gathering information of what and how each participant may utilize the program. The activities and strategies found useful in this analysis will provide valuable information in brush-ups of the program itself and of mobile health (mHealth) in general. Japanese Clinical Trials Registry UMIN CTR 000013693; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ ctr_view.cgi?recptno=R000015984 (Archived by WebCite at http://www.webcitation.org/6u6pxVwik). ©Toshi A Furukawa, Masaru Horikoshi, Hirokazu Fujita, Naohisa Tsujino, Ran Jinnin, Yuki Kako, Sei Ogawa, Hirotoshi Sato, Nobuki Kitagawa, Yoshihiro Shinagawa, Yoshio Ikeda, Hissei Imai, Aran Tajika, Yusuke Ogawa, Tatsuo Akechi, Mitsuhiko Yamada, Shinji Shimodera, Norio Watanabe, Masatoshi Inagaki, Akio Hasegawa. Originally published in JMIR Mental Health (http://mental.jmir.org), 11.01.2018.

Exchange transfusion with fluorocarbon for studying synaptically evoked optical signal in rat cortex.

Science.gov (United States)

Nomura, Y; Fujii, F; Sato, C; Nemoto, M; Tamura, M

2000-02-01

. Zieglgansberger, The intrinsic optical signal evoked by chiasm stimulation in the rat suprachiasmatic nuclei exhibits GABAergic day-night variation, Eur. J. Neurosci. 8 (1996) 319-328] [3] [9] [13] [24]. A spectral fitting method with three components is used for the analysis of intrinsic optical signal [M. Nemoto, Y. Nomura, C. Sato, M. Tamura, K. Houkin, I. Koyanagi, H. Abe, Analysis of optical signals evoked by peripheral nerve stimulation in rat somatosensory cortex: dynamic changes in hemoglobin concentration and oxygenation, J. Cereb. Blood Flow Metab. 19 (1999) 246-259] [17]. In order to validate the analysis, we need the knowledge on contribution of signal resulted from hemoglobin to total intrinsic optical signal. The exchange transfusion with fluorocarbon has the advantage that can change the spectral contribution of hemoglobin [M. Ferrari, M.A. Williams, D.A. Wilson, N.V. Thakor, R.J. Traystman, D.F. Hanley, Cat brain cytochrome-c oxidase redox changes induced by hypoxia after blood-fluorocarbon exchange transfusion, Am. J. Physiol. 269 (1995) H417-H424; A.L. Sylvia, C.A. Piantadosi, O(2) dependence of in vivo brain cytochrome redox responses and energy metabolism in bloodless rats, J. Cereb. Blood Flow Metab. 8 (1988) 163-172] [6] [23]. Here we describe a new method of the reduction of hemoglobin signal from somatosensory evoked optical intrinsic signal in rat cortex by the combination of exchange transfusion with fluorocarbon and imaging system of thinned skull cranial window. The method allows for the study of the synaptically evoked changes in light scattering as well as fluorescence of calcium indicator or voltage-sensitive dye without absorption of hemoglobin.

Are distribution coefficients measured from batch experiments meaningful for quantifying retention in compacted material?

Energy Technology Data Exchange (ETDEWEB)

Goutelard, F.; Charles, Y.; Page, J. [CEA/DEN/DPC/SECR/L3MR batiment 450, 91191 Gif sur Yvette (France)

2005-07-01

}Ni are used to quantify the distribution coefficient. The equilibrium state is checked with activity measurement of the aqueous phase at consistent elapse time. Callovo-Oxfordian argillite is a natural compacted material, then square pieces (1 x 1 cm{sup 2}) are produced from rough material. In the simulated site water, the Callovo-Oxfordian argillite does not weather. In order to ensure that chemical equilibrium is reached before addition of radioactive tracers, a pre-equilibration period is going on for at least 2 month. All adsorption experiments are followed by desorption experiments. The distribution coefficient onto aqueous suspensions of bentonite and Callovo-Oxfordian are calculated and compared to those found for compacted materials. Main results are discussed towards literature values. [1] Miyahara, K. A., T.; Kohara,Y.; Yusa,Y.; Sasaki, N. (1991). 'Effect of bulk density on diffusion for cesium in compacted sodium bentonite'. Radiochimica acta 52/53: 293-297. [2] Sato, H. A., T.; kohara, Y.; Yui, M.; Sasaki, N. (1992). 'Effect of dry density of some radionuclides in compacted sodium bentonite'. Journal of Nuclear Science and technology 29(9): 873-882. [3] Ly, J. L. V., J-C.; Meier, P. (1998). Retention dans une barriere argileuse en milieu granitique: Effet de la consolidation et de la composition de l'eau. Paris, CEA: 32. (authors)

Are distribution coefficients measured from batch experiments meaningful for quantifying retention in compacted material?

International Nuclear Information System (INIS)

Goutelard, F.; Charles, Y.; Page, J.

2005-01-01

distribution coefficient. The equilibrium state is checked with activity measurement of the aqueous phase at consistent elapse time. Callovo-Oxfordian argillite is a natural compacted material, then square pieces (1 x 1 cm 2 ) are produced from rough material. In the simulated site water, the Callovo-Oxfordian argillite does not weather. In order to ensure that chemical equilibrium is reached before addition of radioactive tracers, a pre-equilibration period is going on for at least 2 month. All adsorption experiments are followed by desorption experiments. The distribution coefficient onto aqueous suspensions of bentonite and Callovo-Oxfordian are calculated and compared to those found for compacted materials. Main results are discussed towards literature values. [1] Miyahara, K. A., T.; Kohara,Y.; Yusa,Y.; Sasaki, N. (1991). 'Effect of bulk density on diffusion for cesium in compacted sodium bentonite'. Radiochimica acta 52/53: 293-297. [2] Sato, H. A., T.; kohara, Y.; Yui, M.; Sasaki, N. (1992). 'Effect of dry density of some radionuclides in compacted sodium bentonite'. Journal of Nuclear Science and technology 29(9): 873-882. [3] Ly, J. L. V., J-C.; Meier, P. (1998). Retention dans une barriere argileuse en milieu granitique: Effet de la consolidation et de la composition de l'eau. Paris, CEA: 32. (authors)

Photometric parameter maps of the Moon derived from LROC WAC images

Science.gov (United States)

Sato, H.; Robinson, M. S.; Hapke, B. W.; Denevi, B. W.; Boyd, A. K.

2013-12-01

highlands (0.47×0.16). Since c controls the fraction of backward/forward scattering in H-G2, lower c for the maria indicates more forward scattering relative to the highlands. This trend is opposite to what was expected because darker particles are usually more backscattering. However, the lower albedo of the maria is due to the higher abundance of ilmenite, which is an opaque mineral that scatters all of the light by specular reflection from the its surface. If their surface facets are relatively smooth the ilmenite particles will be forward scattering. Other factors (e.g. grain shape, grain size, porosity, maturity) besides the mineralogy might also be affecting c. The angular-width of SHOE (hs) typically shows lower values (0.047×0.02) for the maria relative to the highlands (0.074×0.025). An increase in hs for the maria theoretically suggests lower porosity or a narrower grain size distribution [1], but the link between actual materials and hs is not well constrained. Further experiments using both laboratory and spacecraft observations will help to unravel the photometric properties of the surface materials of the Moon. [1] Hapke, B.: Cambridge Univ. Press, 2012. [2] Sato, H. et al.: 42nd LPSC, abstract #1974, 2011. [3] Scholten, F. et al.: JGR, 117, E00H17, 2012. [4] Hapke, B.: Icarus, 221(2), p1079-1083, 2012.

Autonomic nervous system activity during acclimatization after rapid air travel across time zones: A case study [Aktivita autonomního nervového systému během aklimatizace po rychlém přeletu časových pásem: Kazuistika

Directory of Open Access Journals (Sweden)

Michal Botek

2009-06-01

Full Text Available BACKGROUND: The rapid transition across time zones also known as jet lag syndrome leads to desynchronization of our endogenous "biological" clock and causes a transient decrease in the adaptation capacity of an athlete. OBJECTIVE: The aim of this study was to verify the use of the spectral analysis of heart rate variability (SA HRV method as a tool for classification of the answer of the body to both the rapid transition across time zones and the training intensity level during the following acclimatization. METHODS: Changes in autonomic activity were assessed by SA HRV during acclimatization after eastward (+6 hours and westward (–7 hours flights in two elite athletes. RESULTS: The results revealed that the athlete, who undertook a flight from Prague to Beijing (China, was able to start with intensive training during the fourth day of his acclimatization. No acute decrease in training ability (adaptability was found in the athlete after the flight from Prague to Bogota (Columbia. Significant modifications in her training load level were made only on the third day in Columbia. The study confirmed that the reaction of the body to the rapid transition across time zones is highly individual. CONCLUSIONS: Therefore, in the future, the SA HRV method could become a promising tool for solving questions of both the acclimatization strategy and the optimizing of sport performance in elite athletes. [VÝCHODISKA: Vlivem rychlého přesunu přes časová pásma dochází k poruše vnitřních regulací organismu, které mohou být u sportovců příčinou přechodného poklesu jejich tréninkové adaptační kapacity. CÍLE: Cílem práce bylo ověřit možnost využití metody spektrální analýzy variability srdeční frekvence (SA HRV jako nástroje pro hodnocení aktivity autonomního nervového systému (ANS, který se podílí na regulaci těchto změn souvisejících s aklimatizací. METODY: U dvou vrcholových sportovců, kteří absolvovali p

Adherence to physical activity in patients with coronary artery disease [Adherence k pohybové aktivitě u pacientů s kardiovaskulárním onemocněním

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Hana Cipryanová

2010-12-01

ční ve věku 61,95 ± 11,02 let. Podle metodiky kontroly PA byli pacienti rozděleni do tří skupin. Skupina 1 (G1 používala krokoměr, skupina 2 (G2 monitor srdeční frekvence a skupina 3 (G3 oba přístroje současně. Pacienti zapisovali počet kroků, trvání cvičení (G1 a G3 nebo průměrnou srdeční frekvenci (G2 a G3 do záznamových archů. Kontrola sledovaných laboratorních a klinických ukazatelů probíhala po 3, 6 a 12 měsících. VÝSLEDKY: Adherence k programu byla velmi variabilní (60-360 dní, nejnižší byla u pacientů skupiny G2 a nejvyšší ve skupině G3. Program dokončili pouze dva pacienti ze skupiny G3 (10 % z celkového počtu intervenovaných pacientů. Mezi jednotlivými skupinami jsme nezaznamenali statisticky významný rozdíl v žádném ze sledovaných ukazatelů kvality pohybové intervence (počet kroků, doba cvičení, odhad energetické spotřeby při cvičení. ZÁVĚRY: Jako nejvíce akceptovaný prostředek ke kontrole objemu PA se jevil krokoměr. Velmi nízká adherence vyplývá z pevné fixace většinou několik desítek let trvajícího sedavého životního stylu a často má psychologické a sociální příčiny.

Diferenças entre o homem e a mulher na apresentação clínica de doentes diagnosticados com síndroma de apneia obstrutiva do sono Differences between men and women in the clinical presentation of patients diagnosed with obstructive sleep apnea syndrome

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MR Shepertycky

2006-05-01

corporal, índice de apneia/hipopneia, score da escala de sono de Epworth e T 90 (número de minutos com Sat.O 2 < 90% não diferiram significativamente do ponto de vista estatístico, entre os dois grupos. Apneia foi definida como a cessação total do fluxo aéreo oronasal durante o sono ≥ 10 seg. e hipopneia como a redução de 50% do fluxo aéreo oronasal ≤ 10 seg, que se acompanha de um despertar transitório não consciente/microdespertares e/ou dessaturação da oxihemoglobina ≥ 4%. Apesar da hipersonolência diurna e o ressonar serem similares em ambos os grupos, verificou-se que um maior número de mulheres referia como sintoma major a insónia sendo as palpitações e o edema dos membros inferiores mais frequentes no sexo feminino. As mulheres com SAOS tinham uma maior prevalência de depressão (21% versus 7%, estando sob terapêutica com psicofármacos 25% em comparação com 8% da população masculina. O mesmo se verificou em relação ao hipotiroidismo (22% versus 4% e a asma brônquica e alergias (35% versus 22%. Não houve diferenças estatisticamente significativas em relação a doenças cardíacas, HTA e diabetes mellitus. O consumo de álcool e de cafeína era inferior no sexo feminino.

Hemogasometria e variáveis cardiopulmonares após administração do butorfanol em cães anestesiados pelo desfluorano sob ventilação espontânea Acid-base and cardiopulmonary effects after butorphanol administration in spontaneously breathing dogs anesthetized by desflurane

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Paulo Sérgio Patto dos Santos

2007-04-01

Full Text Available Este experimento teve por objetivos avaliar as possíveis alterações cardiopulmonares e hemogasométricas decorrentes do uso do butorfanol em cães submetidos à anestesia pelo desfluorano sob ventilação espontânea. Para tal, foram utilizados vinte cães adultos, clinicamente saudáveis, pesando 12±3kg. Os animais foram distribuídos igualmente em dois grupos, GS e GB, e induzidos à anestesia com propofol (8,4±0,8mg kg-1, IV, intubados e submetidos à anestesia inalatória pelo desfluorano (10V%. Decorridos 40 minutos da indução, foi administrado aos animais do GS 0,05mL kg-1 de solução fisiológica a 0,9% (salina, enquanto que, no GB, foi aplicado butorfanol na dose de 0,4mg kg-1, ambos pela via intramuscular. As observações das variáveis freqüências cardíaca (FC e respiratória (f, pressões arteriais sistólica (PAS, diastólica (PAD e média (PAM, pH arterial (pH, pressão parcial de oxigênio no sangue arterial (PaO2, pressão parcial de dióxido de carbono no sangue arterial (PaCO2, déficit de base (DB, bicarbonato (HCO3 e saturação de oxigênio na hemoglobina (SatO2 tiveram início imediatamente antes da aplicação do opióide ou salina (M0. Novas mensurações foram realizadas 15 minutos após a administração do butorfanol ou salina (M15 e as demais colheitas foram realizadas a intervalos de 15 minutos, por um período de 60 minutos (M30, M45, M60 e M75. Os dados numéricos dessas variáveis foram submetidos à Análise de Perfil (PThe cardiopulmonary and acid-base effects of butorphanol in desflurane anesthetized dogs breathing spontaneously were evaluated. Twenty adult healthy, male and female dogs were used. They were separated into two groups of 10 animals each (GS and GB. Anesthesia was induced with propofol (8.4±0.8mg kg-1 IV and maintained with desflurane (10V%. After 40 minutes of induction, the animals from GS received saline solution at 0.9% (0.05mL kg-1 and from GB received butorphanol (0.4mg kg-1

Human Monoclonal antibodies - A dual advantaged weapon to tackle cancer and viruses

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Kurosawa G

2014-11-01

has been working on newer technologies for developing human mAbs. For the comprehensive isolation of mAbs, we have developed a method known as ICOS (isolation of antigen–antibody complexes through organic solvent method (1, in which phage particles of an antibody (Ab library are mixed with living cells which leads to formation of antigen (Ag–Ab complexes on the cell surface. The mixture is then overlaid on organic solution and phage bound to cells are recovered from the precipitate after centrifugation [1]. Further, for the rapid identification of Antigens (Ags recognized by the several mAbs, we have developed the GFC [grouping of clones by flow cytometry (FCM] method and the SITE (simultaneous identification of clones through three dimensional ELISA method [2]. These methods helped us to identify 24 distinct tumour associated antigens (TAAs that are associated with several carcinomas and we were able to isolate 432 human mAbs that specifically bound to one of the 24 TAAs [2], making these mAbs potential therapeutic agents against a variety of cancers. To understand the way forward from our perspectives, a clear knowledge on the following are indispensable Differences between human Abs and the other Abs such as mouse, chimeric and humanized Abs. Differences between Abs and small molecules. Differences between Abs and vaccination. How to materialize best agents using human mAbs. References Akahori Y, Kurosawa G, Sumitomo M, Morita M, Muramatsu C, Eguchi K, Tanaka M, Suzuki K, Sugiura M, Iba Y, Sugioka A, Kurosawa Y. Isolation of antigen/antibody complexes through organic solvent (ICOS method. Biochem Biophys Res Commun. 2009;378(4:832-5. Kurosawa G, Sumitomo M, Akahori Y, Matsuda K, Muramatsu C, Takasaki A, Iba Y, Eguchi K, Tanaka M, Suzuki K, Morita M, Sato N, Sugiura M, Sugioka A, Hayashi N, Kurosawa Y. Methods for comprehensive identification of membrane proteins recognized by a large number of monoclonal antibodies. J Immunol Methods. 2009;351(1-2:1-12.

Antiradiation Vaccine: Technology Development- Radiation Tolerance,Prophylaxis, Prevention And Treatment Of Clinical Presentation After Heavy Ion Irradiation.

Science.gov (United States)

Popov, Dmitri; Maliev, Slava; Jones, Jeffrey

Introduction: Research in the field of biological effects of heavy charged particles is necessary for both heavy-ion therapy (hadrontherapy) and protection from the exposure to galactic cosmic radiation in long-term manned space missions.[Durante M. 2004] In future crew of long-term manned missions could operate in exremely high hadronic radiation areas of space and will not survive without effective radiation protection. An Antiradiation Vaccine (AV) must be an important part of a countermeasures regimen for efficient radiation protection purposes of austronauts-cosmonauts-taukonauts: immune-prophylaxis and immune-therapy of acute radiation toxic syndromes developed after heavy ion irradiation. New technology developed (AV) for the purposes of radiological protection and improvement of radiation tolerance and it is quite important to create protective immune active status which prevent toxic reactions inside a human body irradiated by high energy hadrons.[Maliev V. et al. 2006, Popov D. et al.2008]. High energy hadrons produce a variety of secondary particles which play an important role in the energy deposition process, and characterise their radiation qualities [Sato T. et al. 2003] Antiradiation Vaccine with specific immune-prophylaxis by an anti-radiation vaccine should be an important part of medical management for long term space missions. Methods and experiments: 1. Antiradiation vaccine preparation standard, mixture of toxoid form of Radiation Toxins [SRD-group] which include Cerebrovascular RT Neurotoxin, Cardiovascular RT Neurotoxin, Gastrointestinal RT Neurotoxin, Hematopoietic RT Hematotoxin. Radiation Toxins of Radiation Determinant Group isolated from the central lymph of gamma-irradiated animals with Cerebrovascular, Cardiovascular, Gastro-intestinal, Hematopoietic forms of ARS. Devices for radiation are "Panorama", "Puma". 2. Heavy ion exposure was accomplished at Department of Research Institute of Nuclear Physics, Dubna, Russia. The heavy ions

List of Participants

Science.gov (United States)

2011-08-01

Abigail Alvarez OlarteCINVESTAV Alba Leticia Carrillo MonteverdeDCI-UG Alberto CarramiñanaINAOE Aldo MorselliFERMI Alejandro CastillaDCI-UG Alejandro IbarraTechnical University of Munich Alma D Rojas PachecoFCFM-BUAP Alma Xochitl Gonzalez MoralesInstituto de Ciencias Nucleares, UNAM Andrew Walcott BeckwithAmerican Institute of Beam Energy Physics Ariadna Montiel ArenasDepartamento de Física, CINVESTAV Arnulfo ZepedaCinvestav Arturo Alvarez CruzInstituto de Fisica, UNAM Axel de la MacorraUNAM, IAC Azar MustafayevUniversity of Minnesota Benjamin JaramilloDCI-UG Vincent BertinCPPM-Marseille Carlos Alberto Vaquera-AraujoDCI-UG Carlos MuñozMadrid Autonoma U. & Madrid, IFT Carmine PagliaroneINFN, FNAL Carolina Lujan PeschardDCI-UG Christiane Frigerio MartinsUniversidade Federal do ABC-São Paulo Csaba BalazsMonash University David DelepineDCI-UG David G CerdenoUniversidad Autonoma de Madrid & Instituto de Fisica Teorica Debasish MajumdarSaha Institute of Nuclear Physics, Kolkata, India Dibyendu PanigrahiKandi Raj College, Kandi, Murshidabad, INDIA-742137 Dupret Alberto Santana BejaranoUniversidad de Sonora Departamento de Investigacion en Fisica Ernest MaRiverside U.C. Esteban Alejandro Reyes Pírez MontañezInstituto de Física, UNAM Federico Ortiz TrejoINSTITUTO DE ASTRONOMÍA - UNAM Francisco José de Anda NavarroUniversidad de Guadalajara González Alvarez Francisco JavierCINVESTAV-Depto. Física Gustavo Medina TancoICN-UNAM Hernando Efrain Caicedo OrtizInstituto Politecnico Nacional - IPN J D VergadosCERN & Ioannina U. James R BoyceJefferson Lab Jason SteffenFERMILAB Javier Montaño DomínguezDCI-UG Jeevan SolankiMandsaur Institue of Technology MP India Joe SatoSaitama University Jorge Luis Navarro EstradaUNAM-ICN and Universidad del Atlantico (B/quilla-Col.) Jose A R CembranosUniversity of Minnesota José DíazIFIC Jose Didino Garcia AguilarDepto. de Fisica. Cinvestav Keith OliveUniversity of Minnesota Konstantia BalasiUniversity of Ioannina, Greece Lilian Prado