WorldWideScience

Sample records for testbed cart site

  1. Environmental assessment for the Atmospheric Radiation Measurement (ARM) Program: Southern Great Plains Cloud and Radiation Testbed (CART) site

    Energy Technology Data Exchange (ETDEWEB)

    Policastro, A.J.; Pfingston, J.M.; Maloney, D.M.; Wasmer, F.; Pentecost, E.D.

    1992-03-01

    The Atmospheric Radiation Measurement (ARM) Program is aimed at supplying improved predictive capability of climate change, particularly the prediction of cloud-climate feedback. The objective will be achieved by measuring the atmospheric radiation and physical and meteorological quantities that control solar radiation in the earth`s atmosphere and using this information to test global climate and related models. The proposed action is to construct and operate a Cloud and Radiation Testbed (CART) research site in the southern Great Plains as part of the Department of Energy`s Atmospheric Radiation Measurement Program whose objective is to develop an improved predictive capability of global climate change. The purpose of this CART research site in southern Kansas and northern Oklahoma would be to collect meteorological and other scientific information to better characterize the processes controlling radiation transfer on a global scale. Impacts which could result from this facility are described.

  2. Aspects of the quality of data from the Southern Great Plains (SGP) cloud and radiation testbed (CART) site broadband radiation sensors

    Energy Technology Data Exchange (ETDEWEB)

    Splitt, M.E. [Univ. of Oklahoma, Norman, OK (United States); Wesely, M.L. [Argonne National Lab., IL (United States)

    1996-04-01

    A systmatic evaluation of the performance of broadband radiometers at the Radiation Testbed (CART) site is needed to estimate the uncertainties of the irradiance observations. Here, net radiation observed with the net radiometer in the enrgy balance Bowen ratio station at the Central facility is compared with the net radiation computed as the sum of component irradiances recorded by nearby pyranameters and pyrgeometers. In addition, data obtained from the central facility pyranometers, pyrgeometers, and pyrheliometers are examined for April 1994, when intensive operations periods were being carried out. The data used in this study are from central facility radiometers in a solar and infrared observation station, and EBBR station, the so-called `BSRN` set of upward pointing radiometers, and a set of radiometers pointed down at the 25-m level of a 60-m tower.

  3. A boundary-layer cloud study using Southern Great Plains Cloud and radiation testbed (CART) data

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht, B.; Mace, G.; Dong, X.; Syrett, W. [Pennsylvania State Univ., University Park, PA (United States)] [and others

    1996-04-01

    Boundary layer clouds-stratus and fairweather cumulus - are closely coupled involves the radiative impact of the clouds on the surface energy budget and the strong dependence of cloud formation and maintenance on the turbulent fluxes of heat and moisture in the boundary layer. The continuous data collection at the Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site provides a unique opportunity to study components of the coupling processes associated with boundary layer clouds and to provide descriptions of cloud and boundary layer structure that can be used to test parameterizations used in climate models. But before the CART data can be used for process studies and parameterization testing, it is necessary to evaluate and validate data and to develop techniques for effectively combining the data to provide meaningful descriptions of cloud and boundary layer characteristics. In this study we use measurements made during an intensive observing period we consider a case where low-level stratus were observed at the site for about 18 hours. This case is being used to examine the temporal evolution of cloud base, cloud top, cloud liquid water content, surface radiative fluxes, and boundary layer structure. A method for inferring cloud microphysics from these parameters is currently being evaluated.

  4. A comparison of radiometric fluxes influenced by parameterization cirrus clouds with observed fluxes at the Southern Great Plains (SGP) cloud and radiation testbed (CART) site

    Energy Technology Data Exchange (ETDEWEB)

    Mace, G.G.; Ackerman, T.P.; George, A.T. [Penn State Univ., University Park, PA (United States)

    1996-04-01

    The data from the Atmospheric Radiation Measurement (ARM) Program`s Southern Great plains Site (SCP) is a valuable resource. We have developed an operational data processing and analysis methodology that allows us to examine continuously the influence of clouds on the radiation field and to test new and existing cloud and radiation parameterizations.

  5. Cartes

    OpenAIRE

    2014-01-01

    Carte I. République de panama Source : Area Handbook for Panama, Foreign Area Studies of the American University Washington, DC, 1972. Carte II. Zone du canal de panama Source : The Meaning of the New Panama Canal Treaties, Selected Documents, N° 6 C, January 1978, The Department of State, Bureau of Public Affairs, Office of Media Services. Carte III. Position géographique et profil du canal Source : Panama Canal Information Office, Panama Canal Commission, Panama, 1981. Carte IV. Aires de...

  6. Site Scientific Mission Plan for the Southern Great Plains CART site: January--June 1994

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, J.M.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1993-12-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on January 1, 1994, and also looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM Functional Teams (Management Team, Experiment Support Team, Operations Team, Data Management Team, Instrument Team, and Campaign Team), and it serves to disseminate the plans more generally within the ARM Program and among the Science Team. This document includes a description of the site`s operational status and the primary envisaged site activities, together with information concerning approved and proposed Intensive Observation Periods. Amendments will be prepared and distributed whenever the content changes by more than 30% within a six-month period. The primary users of this document are the site operator, the site scientist, the Science Team through the ARM Program Science Director, the ARM Program Experiment Center, and the aforementioned ARM Program Functional Teams. This plan is a living document that will be updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  7. Site scientific mission plan for the Southern Great Plains CART Site, January--June 1999

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Sisterson, D.L.; Lamb, P.

    1999-03-10

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site was designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This Site Scientific Mission Plan defines the scientific priorities for site activities during the six months beginning on January 1, 1999, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this document is to provide scientific guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, and Instrument Team [IT]) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the site operator, the site program manager, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  8. Site scientific mission plan for the Southern Great Plains CART site: July--December 1998

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1998-07-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site was designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This Site Scientific Mission Plan defines the scientific priorities for site activities during the six months beginning on July 1, 1998, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this document is to provide scientific guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, and Instrument Team [IT]) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the site operator, the site program manager, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  9. Site scientific mission plan for the Southern Great Plains CART site: January 1997--June 1997

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Institute for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States)

    1997-01-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on January 1, 1997, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, Instrument Team [IT], and Campaign Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the site operator, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  10. Site scientific mission plan for the Southern Great Plains CART site January--June 1996

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1996-01-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. This document defines the scientific priorities for site activities during the six months beginning on January 1, 1996, and looks forward in lesser detail to subsequent six-month periods. The primary purpose of this Site Scientific Mission Plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team [DSIT], Operations Team, instrument Team [IT], and Campaign Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed Intensive Observation Periods (IOPs). The primary users of this document are the site operator, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  11. Site scientific mission plan for the southern Great Plains CART site, January--June 1998

    Energy Technology Data Exchange (ETDEWEB)

    Peppler, R.A.; Lamb, P.J. [Univ. of Oklahoma, Norman, OK (United States). Cooperative Inst. for Mesoscale Meteorological Studies; Sisterson, D.L. [Argonne National Lab., IL (United States). Environmental Research Div.

    1998-01-01

    The Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) site is designed to help satisfy the data needs of the Atmospheric Radiation Measurement (ARM) Program Science Team. The primary purpose of this site scientific mission plan is to provide guidance for the development of plans for site operations. It also provides information on current plans to the ARM functional teams (Management Team, Data and Science Integration Team, Operations Team, and Instrument Team) and serves to disseminate the plans more generally within the ARM Program and among the members of the Science Team. This document includes a description of the operational status of the site and the primary site activities envisioned, together with information concerning approved and proposed intensive observation periods (IOPs). The primary users of this document are the Site operator, the Site Scientist Team (SST), the Science Team through the ARM Program science director, the ARM Program Experiment Center, and the aforementioned ARM Program functional teams. This plan is a living document that is updated and reissued every six months as the observational facilities are developed, tested, and augmented and as priorities are adjusted in response to developments in scientific planning and understanding.

  12. The North Slope of Alaska and Adjacent Arctic Ocean (NSA/AAO) cart site begins operation: Collaboration with SHEBA and FIRE

    Energy Technology Data Exchange (ETDEWEB)

    Zak, D. B.; Church, H.; Ivey, M.; Yellowhorse, L.; Zirzow, J.; Widener, K. B.; Rhodes, P.; Turney, C.; Koontz, A.; Stamnes, K.; Storvold, R.; Eide, H. A.; Utley, P.; Eagan, R.; Cook, D.; Hart, D.; Wesely, M.

    2000-04-04

    Since the 1997 Atmospheric Radiation Measurement (ARM) Science Team Meeting, the North Slope of Alaska and Adjacent Arctic Ocean (NSA/AAO) Cloud and Radiation Testbed (CART) site has come into being. Much has happened even since the 1998 Science Team Meeting at which this paper was presented. To maximize its usefulness, this paper has been updated to include developments through July 1998.

  13. Analytical study of the effects of the Low-Level Jet on moisture convergence and vertical motion fields at the Southern Great Plains Cloud and Radiation Testbed site

    Energy Technology Data Exchange (ETDEWEB)

    Bian, X.; Zhong, S.; Whiteman, C.D.; Stage, S.A. [Pacific Northwest National Lab., Richland, WA (United States)

    1996-04-01

    The Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) is located in a region that is strongly affected by a prominent meteorological phenomenon--the Great Plains Low-Level Jet (LLJ). Observations have shown that the LLJ plays a vital role in spring and summertime cloud formation and precipitation over the Great Plains. An improved understanding of the LLJ characteristics and its impact on the environment is necessary for addressing the fundamental issue of development and testing of radiational transfer and cloud parameterization schemes for the general circulation models (GCMs) using data from the SGP CART site. A climatological analysis of the summertime LLJ over the SGP has been carried out using hourly observations from the National Oceanic and Atmospheric Administration (NOAA) Wind Profiler Demonstration Network and from the ARM June 1993 Intensive Observation Period (IOP). The hourly data provide an enhanced temporal and spatial resolution relative to earlier studies which used 6- and 12-hourly rawinsonde observations at fewer stations.

  14. Development and application of new methods to retrieve vertical structure of precipitation above the ARM CART sites from MMCR measurements

    Energy Technology Data Exchange (ETDEWEB)

    Matrosov, Sergey

    2010-12-15

    The main objective of this project was to develop, validate and apply remote sensing methods to retrieve vertical profiles of precipitation over the DOE ARM CART sites using currently available remote sensors. While the ARM Program invested very heavily into developments of remote sensing methods and instruments for water vapor and non-precipitating cloud parameter retrievals, precipitation retrievals and studies lagged behind. Precipitation, however, is a crucial part of the water cycle, and without detailed information on rainfall and snowfall, significant improvements in the atmospheric models of different scales (i.e., one of the ARM Program's main goals) is difficult to achieve. Characterization of the vertical atmospheric column above the CART sites is also incomplete without detailed precipitation information, so developments of remote sensing methods for retrievals of parameters in precipitating cloud condition was essential. Providing modelers with retrieval results was also one of the key objectives of this research project.

  15. A. Cartes

    OpenAIRE

    2014-01-01

    Carte 1. — La découverte du Río de la Plata par Solís, Cabot et García (1515-1530) Carte 2. — Limites de la « Province Géante des Indes » confiée à Pedro de Mendoza en 1535(d’après Enrique de Gandía, Límites de las gobernaciones sudamericanes en el siglo XVI, Buenos Aires, 1933) Carte 3. — Les expéditions de conquête de Pedro de Mendoza et Alvar Núñez Cabeza de Vaca (1536-1542) Carte 4. — Les « entradas » organisées par Alvar Núñez Cabeza de Vaca et Domingo Martínez de Irala (1543-1553) C...

  16. Objective Determination of Cloud Heights and Radar Reflectivities Using a Combination of Active Remote Sensors at the ARM CART Sites.

    Science.gov (United States)

    Clothiaux, Eugene E.; Ackerman, Thomas P.; Mace, Gerald G.; Moran, Kenneth P.; Marchand, Roger T.; Miller, Mark A.; Martner, Brooks E.

    2000-05-01

    The U.S. Department of Energy's Atmospheric Radiation Measurement (ARM) Program is deploying sensitive, millimeter-wave cloud radars at its Cloud and Radiation Test Bed (CART) sites in Oklahoma, Alaska, and the tropical western Pacific Ocean. The radars complement optical devices, including a Belfort or Vaisala laser ceilometer and a micropulse lidar, in providing a comprehensive source of information on the vertical distribution of hydrometeors overhead at the sites. An algorithm is described that combines data from these active remote sensors to produce an objective determination of hydrometeor height distributions and estimates of their radar reflectivities, vertical velocities, and Doppler spectral widths, which are optimized for accuracy. These data provide fundamental information for retrieving cloud microphysical properties and assessing the radiative effects of clouds on climate. The algorithm is applied to nine months of data from the CART site in Oklahoma for initial evaluation. Much of the algorithm's calculations deal with merging and optimizing data from the radar's four sequential operating modes, which have differing advantages and limitations, including problems resulting from range sidelobes, range aliasing, and coherent averaging. Two of the modes use advanced phase-coded pulse compression techniques to yield approximately 10 and 15 dB more sensitivity than is available from the two conventional pulse modes. Comparison of cloud-base heights from the Belfort ceilometer and the micropulse lidar confirms small biases found in earlier studies, but recent information about the ceilometer brings the agreement to within 20-30 m. Merged data of the radar's modes were found to miss approximately 5.9% of the clouds detected by the laser systems. Using data from only the radar's two less-sensitive conventional pulse modes would increase the missed detections to 22%-34%. A significant remaining problem is that the radar's lower-altitude data are often

  17. Atmospheric Line of Site Experiment (ALOSE) Final Campaign Summary

    Energy Technology Data Exchange (ETDEWEB)

    Smith, W. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States); Green, S. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States); Howard, M. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States); Yesalusky, M. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States); Modlin, N. [Atmospheric Radiation Measurement (ARM) Climate Research Facility, Washington, DC (United States)

    2016-03-01

    The Atmospheric Line of Site Experiment (ALOSE) was a project to produce best-estimate atmospheric state measurements at the: 1. DOE Atmospheric Radiation Measurement (ARM) Clouds and Radiation Test-bed (CART) site located in Lamont, Oklahoma (11–14 December 2012) 2. Poker Flat Alaska Research Range (PFRR) located in Poker Flat, Alaska (19–26 February 2013) 3. DOE ARM CART site located in Lamont, Oklahoma (24–28 April 2013) 4. DOE ARM CART site located in Lamont, Oklahoma (9–15 July 2013) 5. DOE ARM Tropical Western Pacific (TWP) site located in Darwin, Australia (27 September–3 October 2013).

  18. Clinical trials of CAR-T cells in China

    Directory of Open Access Journals (Sweden)

    Bingshan Liu

    2017-10-01

    Full Text Available Abstract Novel immunotherapeutic agents targeting tumor-site microenvironment are revolutionizing cancer therapy. Chimeric antigen receptor (CAR-engineered T cells are widely studied for cancer immunotherapy. CD19-specific CAR-T cells, tisagenlecleucel, have been recently approved for clinical application. Ongoing clinical trials are testing CAR designs directed at novel targets involved in hematological and solid malignancies. In addition to trials of single-target CAR-T cells, simultaneous and sequential CAR-T cells are being studied for clinical applications. Multi-target CAR-engineered T cells are also entering clinical trials. T cell receptor-engineered CAR-T and universal CAR-T cells represent new frontiers in CAR-T cell development. In this study, we analyzed the characteristics of CAR constructs and registered clinical trials of CAR-T cells in China and provided a quick glimpse of the landscape of CAR-T studies in China.

  19. Mercury Shopping Cart Interface

    Science.gov (United States)

    Pfister, Robin; McMahon, Joe

    2006-01-01

    Mercury Shopping Cart Interface (MSCI) is a reusable component of the Power User Interface 5.0 (PUI) program described in another article. MSCI is a means of encapsulating the logic and information needed to describe an orderable item consistent with Mercury Shopping Cart service protocol. Designed to be used with Web-browser software, MSCI generates Hypertext Markup Language (HTML) pages on which ordering information can be entered. MSCI comprises two types of Practical Extraction and Report Language (PERL) modules: template modules and shopping-cart logic modules. Template modules generate HTML pages for entering the required ordering details and enable submission of the order via a Hypertext Transfer Protocol (HTTP) post. Shopping cart modules encapsulate the logic and data needed to describe an individual orderable item to the Mercury Shopping Cart service. These modules evaluate information entered by the user to determine whether it is sufficient for the Shopping Cart service to process the order. Once an order has been passed from MSCI to a deployed Mercury Shopping Cart server, there is no further interaction with the user.

  20. Cartes hors-texte

    OpenAIRE

    2013-01-01

    1 – Carte de la Martinique IRD-Bondy-LCA 2 – Carte de situation des Antilles IRD-Bondy-LCA 3 – Carte topo-climatique de la Martinique IRD-Bondy-LCA 4 – Banane et bananeraies en 1969 en Martinique IRD-Bondy-LCA 5 – Banane et bananeraies en 1980 en Martinique IRD-Bondy-LCA 6 – Les sols de Martinique IRD-Bondy-LCA 7 – Canne à sucre en 1969 et 1980 en Martinique IRD-Bondy-LCA

  1. Fast Physics Testbed for the FASTER Project

    Energy Technology Data Exchange (ETDEWEB)

    Lin, W.; Liu, Y.; Hogan, R.; Neggers, R.; Jensen, M.; Fridlind, A.; Lin, Y.; Wolf, A.

    2010-03-15

    This poster describes the Fast Physics Testbed for the new FAst-physics System Testbed and Research (FASTER) project. The overall objective is to provide a convenient and comprehensive platform for fast turn-around model evaluation against ARM observations and to facilitate development of parameterizations for cloud-related fast processes represented in global climate models. The testbed features three major components: a single column model (SCM) testbed, an NWP-Testbed, and high-resolution modeling (HRM). The web-based SCM-Testbed features multiple SCMs from major climate modeling centers and aims to maximize the potential of SCM approach to enhance and accelerate the evaluation and improvement of fast physics parameterizations through continuous evaluation of existing and evolving models against historical as well as new/improved ARM and other complementary measurements. The NWP-Testbed aims to capitalize on the large pool of operational numerical weather prediction products. Continuous evaluations of NWP forecasts against observations at ARM sites are carried out to systematically identify the biases and skills of physical parameterizations under all weather conditions. The highresolution modeling (HRM) activities aim to simulate the fast processes at high resolution to aid in the understanding of the fast processes and their parameterizations. A four-tier HRM framework is established to augment the SCM- and NWP-Testbeds towards eventual improvement of the parameterizations.

  2. CART neurons in the arcuate nucleus and lateral hypothalamic area exert differential controls on energy homeostasis.

    Science.gov (United States)

    Lau, Jackie; Farzi, Aitak; Qi, Yue; Heilbronn, Regine; Mietzsch, Mario; Shi, Yan-Chuan; Herzog, Herbert

    2018-01-01

    The cocaine- and amphetamine-regulated transcript (CART) codes for a pivotal neuropeptide important in the control of appetite and energy homeostasis. However, limited understanding exists for the defined effector sites underlying CART function, as discrepant effects of central CART administration have been reported. By combining Cart-cre knock-in mice with a Cart adeno-associated viral vector designed using the flip-excision switch (AAV-FLEX) technology, specific reintroduction or overexpression of CART selectively in CART neurons in the arcuate nucleus (Arc) and lateral hypothalamic area (LHA), respectively, was achieved. The effects on energy homeostasis control were investigated. Here we show that CART neuron-specific reintroduction of CART into the Arc and LHA leads to distinct effects on energy homeostasis control. Specifically, CART reintroduction into the Arc of otherwise CART-deficient Cart cre/cre mice markedly decreased fat mass and body weight, whereas CART reintroduction into the LHA caused significant fat mass gain and lean mass loss, but overall unaltered body weight. The reduced adiposity in Arc CART ;Cart cre/cre mice was associated with an increase in both energy expenditure and physical activity, along with significantly decreased Npy mRNA levels in the Arc but with no change in food consumption. Distinctively, the elevated fat mass in LHA CART ;Cart cre/cre mice was accompanied by diminished insulin responsiveness and glucose tolerance, greater spontaneous food intake, and reduced energy expenditure, which is consistent with the observed decrease of brown adipose tissue temperature. This is also in line with significantly reduced tyrosine hydroxylase (Th) and notably increased corticotropin-releasing hormone (Crh) mRNA expressions in the paraventricular nucleus (PVN). Taken together, these results identify catabolic and anabolic effects of CART in the Arc and LHA, respectively, demonstrating for the first time the distinct and region

  3. Jeux de cartes

    Directory of Open Access Journals (Sweden)

    Pierre GENTELLE

    1986-09-01

    Full Text Available Dans la grande tradition de la science-fiction et des lieux imaginaires traduits ici en «jeux» de cartes, l'auteur bouleverse quelques localisations au prix de mouvements tectoniques imprévus et en prévoit quelques conséquences.

  4. Terrestrial Plume Impingement Testbed Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Masten Space Systems proposes to create a terrestrial plume impingement testbed for generating novel datasets for extraterrestrial robotic missions. This testbed...

  5. Tables des cartes, graphiques, tableaux

    OpenAIRE

    2015-01-01

    Carte 1. Nombre d’indigents secourus pour 1 000 habitants dans les départements français en 1847 65 Carte 2. Taux de mendicité dans les départements français en 1847 66 Carte 3. Taux de personnes recensées en Bretagne Sud au milieu du xixe siècle sous les rubriques « mendiants, vagabonds, bohémiens » ou « sans profession » 70 Carte 4. Taux d’indigence dans les Côtes-du-Nord en 1854 71 Carte 5. Taux d’indigence en Ille-et-Vilaine en 1890 72 Carte 6. Taux de personnes inscrites sur les listes d...

  6. A New Take on Exploding Carts

    Science.gov (United States)

    Broder, Darren; Burleigh, James; Christian, Matthew; Mowry, Shawn; Hassel, George E.

    2017-01-01

    The Exploding Carts is a popular introductory physics activity in which a one-dimensional explosion is simulated utilizing two dynamics carts that are pushed apart by a spring-loaded plunger released from one of the carts. Traditional treatments of the Exploding Carts usually involve multiple trials where the mass of one or both of the carts is…

  7. Virtual Factory Testbed

    Data.gov (United States)

    Federal Laboratory Consortium — The Virtual Factory Testbed (VFT) is comprised of three physical facilities linked by a standalone network (VFNet). The three facilities are the Smart and Wireless...

  8. Controlling errors in unidosis carts

    Directory of Open Access Journals (Sweden)

    Inmaculada Díaz Fernández

    2010-01-01

    Full Text Available Objective: To identify errors in the unidosis system carts. Method: For two months, the Pharmacy Service controlled medication either returned or missing from the unidosis carts both in the pharmacy and in the wards. Results: Uncorrected unidosis carts show a 0.9% of medication errors (264 versus 0.6% (154 which appeared in unidosis carts previously revised. In carts not revised, the error is 70.83% and mainly caused when setting up unidosis carts. The rest are due to a lack of stock or unavailability (21.6%, errors in the transcription of medical orders (6.81% or that the boxes had not been emptied previously (0.76%. The errors found in the units correspond to errors in the transcription of the treatment (3.46%, non-receipt of the unidosis copy (23.14%, the patient did not take the medication (14.36%or was discharged without medication (12.77%, was not provided by nurses (14.09%, was withdrawn from the stocks of the unit (14.62%, and errors of the pharmacy service (17.56% . Conclusions: It is concluded the need to redress unidosis carts and a computerized prescription system to avoid errors in transcription.Discussion: A high percentage of medication errors is caused by human error. If unidosis carts are overlooked before sent to hospitalization units, the error diminishes to 0.3%.

  9. Fan Cart: The Next Generation

    Science.gov (United States)

    Lamore, Brian

    2016-01-01

    For years the fan cart has provided physics students with an excellent resource for exploring fundamental mechanics concepts such as acceleration, Newton's laws, impulse, momentum, work-energy, and energy conversions. "The Physics Teacher" has even seen some excellent do-it-yourself (DIY) fan carts and activities. If you are interested…

  10. A la Carte Community

    DEFF Research Database (Denmark)

    Gundelach, Peter; Brincker, Benedikte

    2010-01-01

    The exchange of open source software is a phenomenon that is becoming in- creasingly significant to IT users. This article presents the results of a study of the TYPO3 community, a community related to an open source CMS software. The article explores the community, identity and values of TYPO3...... and shows that there are high levels of virtual as well as face-to-face interaction among the members. The participants feel that they belong to the community and many also feel that they are recognised as part of the community. However, the members do not share common values neither in relation to software...... pro- duction nor generally. Instead, they stress that you are free to choose your own values. Against this background, the authors introduce the notion of an ‘a la carte community', i.e. a community where individuals pick and choose their degree of participation and integra- tion into the community...

  11. WFIRST Coronagraph Technology Development Testbeds: Status and Recent Testbed Results

    Science.gov (United States)

    Shi, Fang; An, Xin; Balasubramanian, Kunjithapatham; cady, eric; Gordon, Brian; Greer, Frank; Kasdin, N. Jeremy; Kern, Brian; Lam, Raymond; Marx, David; Moody, Dwight; Patterson, Keith; Poberezhskiy, Ilya; mejia prada, camilo; Gersh-Range, Jessica; Eldorado Riggs, A. J.; Seo, Byoung-Joon; Shields, Joel; Sidick, Erkin; Tang, Hong; Trauger, John Terry; Truong, Tuan; White, Victor; Wilson, Daniel; Zhou, Hanying; JPL WFIRST Testbed Team, Princeton University

    2018-01-01

    As a part of technology development for the WFIRST coronagraph instrument (CGI), dedicated testbeds are built and commissioned at JPL. The coronagraph technology development testbeds include the Occulting Mask Coronagraph (OMC) testbed, the Shaped Pupil Coronagraph/Integral Field Spectrograph (SPC/IFS) testbed, and the Vacuum Surface Gauge (VSG) testbed. With its configuration similar to the WFIRST flight coronagraph instrument the OMC testbed consists of two coronagraph modes, Shaped Pupil Coronagraph (SPC) and Hybrid Lyot Coronagraph (HLC), a low order wavefront sensor (LOWFS), and an optical telescope assembly (OTA) simulator which can generate realistic LoS drift and jitter as well as low order wavefront error that would be induced by the WFIRST telescope’s vibration and thermal changes. The SPC/IFS testbed is a dedicated testbed to test the IFS working with a Shaped Pupil Coronagraph while the VSG testbed is for measuring and calibrating the deformable mirrors, a key component used for WFIRST CGI's wavefront control. In this poster, we will describe the testbed functions and status as well as the highlight of the latest testbed results from OMC, SPC/IFS and VSG testbeds.

  12. Network testbed creation and validation

    Energy Technology Data Exchange (ETDEWEB)

    Thai, Tan Q.; Urias, Vincent; Van Leeuwen, Brian P.; Watts, Kristopher K.; Sweeney, Andrew John

    2017-03-21

    Embodiments of network testbed creation and validation processes are described herein. A "network testbed" is a replicated environment used to validate a target network or an aspect of its design. Embodiments describe a network testbed that comprises virtual testbed nodes executed via a plurality of physical infrastructure nodes. The virtual testbed nodes utilize these hardware resources as a network "fabric," thereby enabling rapid configuration and reconfiguration of the virtual testbed nodes without requiring reconfiguration of the physical infrastructure nodes. Thus, in contrast to prior art solutions which require a tester manually build an emulated environment of physically connected network devices, embodiments receive or derive a target network description and build out a replica of this description using virtual testbed nodes executed via the physical infrastructure nodes. This process allows for the creation of very large (e.g., tens of thousands of network elements) and/or very topologically complex test networks.

  13. Network testbed creation and validation

    Science.gov (United States)

    Thai, Tan Q.; Urias, Vincent; Van Leeuwen, Brian P.; Watts, Kristopher K.; Sweeney, Andrew John

    2017-04-18

    Embodiments of network testbed creation and validation processes are described herein. A "network testbed" is a replicated environment used to validate a target network or an aspect of its design. Embodiments describe a network testbed that comprises virtual testbed nodes executed via a plurality of physical infrastructure nodes. The virtual testbed nodes utilize these hardware resources as a network "fabric," thereby enabling rapid configuration and reconfiguration of the virtual testbed nodes without requiring reconfiguration of the physical infrastructure nodes. Thus, in contrast to prior art solutions which require a tester manually build an emulated environment of physically connected network devices, embodiments receive or derive a target network description and build out a replica of this description using virtual testbed nodes executed via the physical infrastructure nodes. This process allows for the creation of very large (e.g., tens of thousands of network elements) and/or very topologically complex test networks.

  14. Adjustable Autonomy Testbed

    Science.gov (United States)

    Malin, Jane T.; Schrenkenghost, Debra K.

    2001-01-01

    The Adjustable Autonomy Testbed (AAT) is a simulation-based testbed located in the Intelligent Systems Laboratory in the Automation, Robotics and Simulation Division at NASA Johnson Space Center. The purpose of the testbed is to support evaluation and validation of prototypes of adjustable autonomous agent software for control and fault management for complex systems. The AA T project has developed prototype adjustable autonomous agent software and human interfaces for cooperative fault management. This software builds on current autonomous agent technology by altering the architecture, components and interfaces for effective teamwork between autonomous systems and human experts. Autonomous agents include a planner, flexible executive, low level control and deductive model-based fault isolation. Adjustable autonomy is intended to increase the flexibility and effectiveness of fault management with an autonomous system. The test domain for this work is control of advanced life support systems for habitats for planetary exploration. The CONFIG hybrid discrete event simulation environment provides flexible and dynamically reconfigurable models of the behavior of components and fluids in the life support systems. Both discrete event and continuous (discrete time) simulation are supported, and flows and pressures are computed globally. This provides fast dynamic simulations of interacting hardware systems in closed loops that can be reconfigured during operations scenarios, producing complex cascading effects of operations and failures. Current object-oriented model libraries support modeling of fluid systems, and models have been developed of physico-chemical and biological subsystems for processing advanced life support gases. In FY01, water recovery system models will be developed.

  15. The Rain-Powered Cart

    Science.gov (United States)

    2016-08-05

    elastically impacted by vertically falling raindrops. The speed of the cart as a function of time can be analytically deduced as an exercise in the use...of trigonometric and hyperbolic functions . A characteristic time defines the approach to a terminal speed which is a sizeable fraction of the speed of...Dassanayake V P C and Hapuwatte B M 2014 Harvesting of kinetic energy of the raindrops Int. J. Math ., Computat., Phys., Elec. Comput. Engin. 8 325–30 [11

  16. Optical Network Testbeds Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Joe Mambretti

    2007-06-01

    This is the summary report of the third annual Optical Networking Testbed Workshop (ONT3), which brought together leading members of the international advanced research community to address major challenges in creating next generation communication services and technologies. Networking research and development (R&D) communities throughout the world continue to discover new methods and technologies that are enabling breakthroughs in advanced communications. These discoveries are keystones for building the foundation of the future economy, which requires the sophisticated management of extremely large qualities of digital information through high performance communications. This innovation is made possible by basic research and experiments within laboratories and on specialized testbeds. Initial network research and development initiatives are driven by diverse motives, including attempts to solve existing complex problems, the desire to create powerful new technologies that do not exist using traditional methods, and the need to create tools to address specific challenges, including those mandated by large scale science or government agency mission agendas. Many new discoveries related to communications technologies transition to wide-spread deployment through standards organizations and commercialization. These transition paths allow for new communications capabilities that drive many sectors of the digital economy. In the last few years, networking R&D has increasingly focused on advancing multiple new capabilities enabled by next generation optical networking. Both US Federal networking R&D and other national R&D initiatives, such as those organized by the National Institute of Information and Communications Technology (NICT) of Japan are creating optical networking technologies that allow for new, powerful communication services. Among the most promising services are those based on new types of multi-service or hybrid networks, which use new optical networking

  17. A New Take on Exploding Carts

    Science.gov (United States)

    Broder, Darren; Burleigh, James; Christian, Matthew; Mowry, Shawn; Hassel, George E.

    2017-11-01

    The Exploding Carts is a popular introductory physics activity in which a one-dimensional explosion is simulated utilizing two dynamics carts that are pushed apart by a spring-loaded plunger released from one of the carts. Traditional treatments of the Exploding Carts usually involve multiple trials where the mass of one or both of the carts is increased, producing explosions with varying post-explosion speeds (the speed at the instant contact is lost between the carts). The subsequent analysis normally entails comparing post-explosion speeds within a given trial, which leads to the concept of momentum and its conservation. Though generally not emphasized in traditional treatments of the Exploding Carts, it is also an interesting endeavor (and the focus of this paper) to compare post-explosion speeds between different trials. Specifically, the post-explosion speed of a constant mass cart in various trials can be compared to the post-explosion speed of the equal mass explosion (no additional mass added to the carts) as the mass of the other cart is changed.

  18. CART peptide induces neuroregeneration in stroke rats.

    Science.gov (United States)

    Luo, Yu; Shen, Hui; Liu, Hua-Shan; Yu, Seong-Jin; Reiner, David J; Harvey, Brandon K; Hoffer, Barry J; Yang, Yihong; Wang, Yun

    2013-02-01

    Utilizing a classic stroke model in rodents, middle cerebral artery occlusion (MCAo), we describe a novel neuroregenerative approach using the repeated intranasal administration of cocaine- and amphetamine-regulated transcript (CART) peptide starting from day 3 poststroke for enhancing the functional recovery of injured brain. Adult rats were separated into two groups with similar infarction sizes, measured by magnetic resonance imaging on day 2 after MCAo, and were treated with CART or vehicle. The CART treatment increased CART level in the brain, improved behavioral recovery, and reduced neurological scores. In the subventricular zone (SVZ), CART enhanced immunolabeling of bromodeoxyuridine, a neural progenitor cell marker Musashi-1, and the proliferating cell nuclear antigen, as well as upregulated brain-derived neurotrophic factor (BDNF) mRNA. AAV-GFP was locally applied to the SVZ to examine migration of SVZ cells. The CART enhanced migration of GFP(+) cells from SVZ toward the ischemic cortex. In SVZ culture, CART increased the size of neurospheres. The CART-mediated cell migration from SVZ explants was reduced by anti-BDNF blocking antibody. Using (1)H-MRS (proton magnetic resonance spectroscopy), increases in N-acetylaspartate levels were found in the lesioned cortex after CART treatment in stroke brain. Cocaine- and amphetamine-regulated transcript increased the expression of GAP43 and fluoro-ruby fluorescence in the lesioned cortex. In conclusion, our data suggest that intranasal CART treatment facilitates neuroregeneration in stroke brain.

  19. Evaluation of Nigerian hospital meal carts

    Science.gov (United States)

    Ayodeji, Sesan P.; Adeyeri, Michael K.; Omoniyi, Olaoluwa

    2015-03-01

    Hospital meal carts are used to deliver meals, drugs and some other materials to patients in the hospital environment. These carts which are moved manually by operators, the health workers, mostly do not comply with ergonomics guidelines and physical requirements of the equipment users in terms of anthropometry data of the region thus increasing the risk of musculoskeletal disorder among the meal cart users. This study carried out ergonomic evaluation of the available meal carts in some western Nigeria hospitals. A well-structured questionnaire has two major segments: Operational survey and biomechanical survey, which were administered to the health workers using hospital meal carts in some hospitals in southwestern Nigeria, and physical assessment, which was undertaken to collect data for the ergonomic evaluation. The responses from the questionnaires show that some areas on the existing hospital meal carts are of concern to the users which need to be improved upon.

  20. The CMS Integration Grid Testbed

    CERN Document Server

    Graham, G E; Aziz, Shafqat; Bauerdick, L.A.T.; Ernst, Michael; Kaiser, Joseph; Ratnikova, Natalia; Wenzel, Hans; Wu, Yu-jun; Aslakson, Erik; Bunn, Julian; Iqbal, Saima; Legrand, Iosif; Newman, Harvey; Singh, Suresh; Steenberg, Conrad; Branson, James; Fisk, Ian; Letts, James; Arbree, Adam; Avery, Paul; Bourilkov, Dimitri; Cavanaugh, Richard; Rodriguez, Jorge Luis; Kategari, Suchindra; Couvares, Peter; DeSmet, Alan; Livny, Miron; Roy, Alain; Tannenbaum, Todd; Graham, Gregory E.; Aziz, Shafqat; Ernst, Michael; Kaiser, Joseph; Ratnikova, Natalia; Wenzel, Hans; Wu, Yujun; Aslakson, Erik; Bunn, Julian; Iqbal, Saima; Legrand, Iosif; Newman, Harvey; Singh, Suresh; Steenberg, Conrad; Branson, James; Fisk, Ian; Letts, James; Arbree, Adam; Avery, Paul; Bourilkov, Dimitri; Cavanaugh, Richard; Rodriguez, Jorge; Kategari, Suchindra; Couvares, Peter; Smet, Alan De; Livny, Miron; Roy, Alain; Tannenbaum, Todd

    2003-01-01

    The CMS Integration Grid Testbed (IGT) comprises USCMS Tier-1 and Tier-2 hardware at the following sites: the California Institute of Technology, Fermi National Accelerator Laboratory, the University of California at San Diego, and the University of Florida at Gainesville. The IGT runs jobs using the Globus Toolkit with a DAGMan and Condor-G front end. The virtual organization (VO) is managed using VO management scripts from the European Data Grid (EDG). Gridwide monitoring is accomplished using local tools such as Ganglia interfaced into the Globus Metadata Directory Service (MDS) and the agent based Mona Lisa. Domain specific software is packaged and installed using the Distrib ution After Release (DAR) tool of CMS, while middleware under the auspices of the Virtual Data Toolkit (VDT) is distributed using Pacman. During a continuo us two month span in Fall of 2002, over 1 million official CMS GEANT based Monte Carlo events were generated and returned to CERN for analysis while being demonstrated at SC2002. ...

  1. The CMS integration grid testbed

    Energy Technology Data Exchange (ETDEWEB)

    Graham, Gregory E.

    2004-08-26

    The CMS Integration Grid Testbed (IGT) comprises USCMS Tier-1 and Tier-2 hardware at the following sites: the California Institute of Technology, Fermi National Accelerator Laboratory, the University of California at San Diego, and the University of Florida at Gainesville. The IGT runs jobs using the Globus Toolkit with a DAGMan and Condor-G front end. The virtual organization (VO) is managed using VO management scripts from the European Data Grid (EDG). Gridwide monitoring is accomplished using local tools such as Ganglia interfaced into the Globus Metadata Directory Service (MDS) and the agent based Mona Lisa. Domain specific software is packaged and installed using the Distribution After Release (DAR) tool of CMS, while middleware under the auspices of the Virtual Data Toolkit (VDT) is distributed using Pacman. During a continuous two month span in Fall of 2002, over 1 million official CMS GEANT based Monte Carlo events were generated and returned to CERN for analysis while being demonstrated at SC2002. In this paper, we describe the process that led to one of the world's first continuously available, functioning grids.

  2. Rolling Friction on a Wheeled Laboratory Cart

    Science.gov (United States)

    Mungan, Carl E.

    2012-01-01

    A simple model is developed that predicts the coefficient of rolling friction for an undriven laboratory cart on a track that is approximately independent of the mass loaded onto the cart and of the angle of inclination of the track. The model includes both deformation of the wheels/track and frictional torque at the axles/bearings. The concept of…

  3. The Ballistic Cart on an Incline Revisited.

    Science.gov (United States)

    Serway, Raymond A.; And Others

    1995-01-01

    Presents the theory behind the mechanics demonstration that involves projecting a ball vertically upward from a ballistic cart moving along an inclined plane. The measured overshoot is believed to be due, in part, to the presence of rolling friction and the inertial properties of the cart wheels. (JRH)

  4. CARTs on the road for myeloma

    Science.gov (United States)

    Maus, Marcela V.; June, Carl H.

    2014-01-01

    Summary Chimeric antigen receptors re-direct T cells to surface antigens. Discovery and validation of appropriate target antigens expands the possible indications for CAR-T cells. CS1 is expressed at high levels by multiple myeloma cells, but also to some extent on other lymphocytes. CS1 may be a viable target for CAR-T cells in multiple myeloma. PMID:24919574

  5. Advanced Artificial Intelligence Technology Testbed

    Science.gov (United States)

    Anken, Craig S.

    1993-01-01

    The Advanced Artificial Intelligence Technology Testbed (AAITT) is a laboratory testbed for the design, analysis, integration, evaluation, and exercising of large-scale, complex, software systems, composed of both knowledge-based and conventional components. The AAITT assists its users in the following ways: configuring various problem-solving application suites; observing and measuring the behavior of these applications and the interactions between their constituent modules; gathering and analyzing statistics about the occurrence of key events; and flexibly and quickly altering the interaction of modules within the applications for further study.

  6. A CART extension using Quadratic Decision Borders

    DEFF Research Database (Denmark)

    Hartelius, Karsten

    1999-01-01

    -space into subsets which are successively more class-homogeneous. Guided by the fact that class-distributions in feature-space are very often hyper-elliptical shaped, we give an extension to the original CART which also uses quadratic shaped decision borders which can be modelled by a mean-vector and a dispersion......In this article we put forward an extention to the hierarchical CART classification method which uses quadratic decision borders. The original CART applies univariate splits on individual variables as well as splits on combinations of variables to recursively partition the feature...

  7. A CART extention using Quadratic Decision Borders

    DEFF Research Database (Denmark)

    Hartelius, Karsten

    1999-01-01

    -space into subsets which are successively more class-homogeneous. Guided by the fact that class-distributions in feature-space are very often hyper-elliptical shaped, we give an extension to the original CART which also uses quadratic shaped decision borders which can be modelled by a mean-vector and a dispersion......In this article we put forward an extention to the hierarchical CART classification method which uses quadratic decision borders. The original CART applies univariate splits on individual variables as well as splits on combinations of variables to recursively partition the feature...

  8. Getting started with OpenCart module development

    CERN Document Server

    Nepali, Rupak

    2013-01-01

    Written as a step-by-step guide, Getting Started with OpenCart Module Development will teach you all you need to know about OpenCart, from custom extensions to module development.This book is for developers who want to develop OpenCart extensions and for those who want to learn more about the code workflow of OpenCart. Basic knowledge of OpenCart would be an added advantage.

  9. EU DataGRID testbed management and support at CERN

    CERN Document Server

    Leonardi, E

    2003-01-01

    In this paper we report on the first two years of running the CERN testbed site for the EU DataGRID project. The site consists of about 120 dual-processor PCs distributed over several testbeds used for different purposes: software development, system integration, and application tests. Activities at the site included test productions of MonteCarlo data for LHC experiments, tutorials and demonstrations of GRID technologies, and support for individual users analysis. This paper focuses on node installation and configuration techniques, service management, user support in a gridified environment, and includes considerations on scalability and security issues and comparisons with "traditional" production systems, as seen from the administrator point of view.

  10. High-contrast imaging testbed

    Energy Technology Data Exchange (ETDEWEB)

    Baker, K; Silva, D; Poyneer, L; Macintosh, B; Bauman, B; Palmer, D; Remington, T; Delgadillo-Lariz, M

    2008-01-23

    Several high-contrast imaging systems are currently under construction to enable the detection of extra-solar planets. In order for these systems to achieve their objectives, however, there is considerable developmental work and testing which must take place. Given the need to perform these tests, a spatially-filtered Shack-Hartmann adaptive optics system has been assembled to evaluate new algorithms and hardware configurations which will be implemented in these future high-contrast imaging systems. In this article, construction and phase measurements of a membrane 'woofer' mirror are presented. In addition, results from closed-loop operation of the assembled testbed with static phase plates are presented. The testbed is currently being upgraded to enable operation at speeds approaching 500 hz and to enable studies of the interactions between the woofer and tweeter deformable mirrors.

  11. Cocaine- and amphetamine-regulated transcript (CART signaling within the paraventricular thalamus modulates cocaine-seeking behaviour.

    Directory of Open Access Journals (Sweden)

    Morgan H James

    Full Text Available BACKGROUND: Cocaine- and amphetamine-regulated transcript (CART has been demonstrated to play a role in regulating the rewarding and reinforcing effects of various drugs of abuse. A recent study demonstrated that i.c.v. administration of CART negatively modulates reinstatement of alcohol seeking, however, the site(s of action remains unclear. We investigated the paraventricular thalamus (PVT as a potential site of relapse-relevant CART signaling, as this region is known to receive dense innervation from CART-containing hypothalamic cells and to project to a number of regions known to be involved in mediating reinstatement, including the nucleus accumbens (NAC, medial prefrontal cortex (mPFC and basolateral amygdala (BLA. METHODOLOGY/PRINCIPAL FINDINGS: Male rats were trained to self-administer cocaine before being extinguished to a set criterion. One day following extinction, animals received intra-PVT infusions of saline, tetrodotoxin (TTX; 2.5 ng, CART (0.625 µg or 2.5 µg or no injection, followed by a cocaine prime (10 mg/kg, i.p.. Animals were then tested under extinction conditions for one hour. Treatment with either TTX or CART resulted in a significant attenuation of drug-seeking behaviour following cocaine-prime, with the 2.5 µg dose of CART having the greatest effect. This effect was specific to the PVT region, as misplaced injections of both TTX and CART resulted in responding that was identical to controls. CONCLUSIONS/SIGNIFICANCE: We show for the first time that CART signaling within the PVT acts to inhibit drug-primed reinstatement of cocaine seeking behaviour, presumably by negatively modulating PVT efferents that are important for drug seeking, including the NAC, mPFC and BLA. In this way, we identify a possible target for future pharmacological interventions designed to suppress drug seeking.

  12. A remote integrated testbed for cooperating objects

    CERN Document Server

    Dios, Jose Ramiro Martinez-de; Bernabe, Alberto de San; Ollero, Anibal

    2013-01-01

    Testbeds are gaining increasing relevance in research domains and also in industrial applications. However, very few books devoted to testbeds have been published. To the best of my knowledge no book on this topic has been published. This book is particularly interesting for the growing community of testbed developers. I believe the book is also very interesting for researchers in robot-WSN cooperation.This book provides detailed description of a system that can be considered the first testbed that allows full peer-to-peer interoperability between heterogeneous robots and ubiquitous systems su

  13. GLYCAN-DIRECTED CAR-T CELLS.

    Science.gov (United States)

    Steentoft, Catharina; Migliorini, Denis; King, Tiffany R; Mandel, Ulla; June, Carl H; Posey, Avery D

    2018-01-23

    Cancer immunotherapy is rapidly advancing in the treatment of a variety of hematopoietic cancers, including pediatric acute lymphoblastic leukemia and diffuse large B cell lymphoma, with chimeric antigen receptor (CAR)-T cells. CARs are genetically encoded artificial T cell receptors that combine the antigen specificity of an antibody with the machinery of T cell activation. However, implementation of CAR technology in the treatment of solid tumors has been progressing much slower. Solid tumors are characterized by a number of challenges that need to be overcome, including cellular heterogeneity, immunosuppressive tumor microenvironment (TME), and, in particular, few known cancer-specific targets. Post-translational modifications that differentially occur in malignant cells generate valid cell surface, cancer-specific targets for CAR-T cells. We previously demonstrated that CAR-T cells targeting an aberrant O-glycosylation of MUC1, a common cancer marker associated with changes in cell adhesion, tumor growth, and poor prognosis, could control malignant growth in mouse models. Here, we discuss the field of glycan-directed CAR-T cells and review the different classes of antibodies specific for glycan-targeting, including the generation of high affinity O-glycopeptide antibodies. Finally, we discuss historic and recently investigated glycan targets for CAR-T cells and provide our perspective on how targeting the tumor glycoproteome and/or glycome will improve CAR-T immunotherapy. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. NASA's telemedicine testbeds: Commercial benefit

    Science.gov (United States)

    Doarn, Charles R.; Whitten, Raymond

    1998-01-01

    The National Aeronautics and Space Administration (NASA) has been developing and applying telemedicine to support space flight since the Agency's beginning. Telemetry of physiological parameters from spacecraft to ground controllers is critical to assess the health status of humans in extreme and remote environments. Requisite systems to support medical care and maintain readiness will evolve as mission duration and complexity increase. Developing appropriate protocols and procedures to support multinational, multicultural missions is a key objective of this activity. NASA has created an Agency-wide strategic plan that focuses on the development and integration of technology into the health care delivery systems for space flight to meet these challenges. In order to evaluate technology and systems that can enhance inflight medical care and medical education, NASA has established and conducted several testbeds. Additionally, in June of 1997, NASA established a Commercial Space Center (CSC) for Medical Informatics and Technology Applications at Yale University School of Medicine. These testbeds and the CSC foster the leveraging of technology and resources between government, academia and industry to enhance health care. This commercial endeavor will influence both the delivery of health care in space and on the ground. To date, NASA's activities in telemedicine have provided new ideas in the application of telecommunications and information systems to health care. NASA's Spacebridge to Russia, an Internet-based telemedicine testbed, is one example of how telemedicine and medical education can be conducted using the Internet and its associated tools. Other NASA activities, including the development of a portable telemedicine workstation, which has been demonstrated on the Crow Indian Reservation and in the Texas Prison System, show promise in serving as significant adjuncts to the delivery of health care. As NASA continues to meet the challenges of space flight, the

  15. Stabilization of an inverted pendulum-cart system by fractional PI-state feedback.

    Science.gov (United States)

    Bettayeb, M; Boussalem, C; Mansouri, R; Al-Saggaf, U M

    2014-03-01

    This paper deals with pole placement PI-state feedback controller design to control an integer order system. The fractional aspect of the control law is introduced by a dynamic state feedback as u(t)=K(p)x(t)+K(I)I(α)(x(t)). The closed loop characteristic polynomial is thus fractional for which the roots are complex to calculate. The proposed method allows us to decompose this polynomial into a first order fractional polynomial and an integer order polynomial of order n-1 (n being the order of the integer system). This new stabilization control algorithm is applied for an inverted pendulum-cart test-bed, and the effectiveness and robustness of the proposed control are examined by experiments. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

  16. Redesigning an airway cart using lean methodology.

    Science.gov (United States)

    Weigel, Wade A

    2016-09-01

    Use lean methodology to create a more efficient difficult airway management equipment transport and setup. The 5S steps of sort, set in order, sweep, standardize, and sustain were used to create a redesigned airway cart. The 5S steps provided the framework to separate the needed from unneeded equipment, logical equipment placement on the cart, and a plan to maintain improvements. Simulations were utilized to compare the revised airway cart to the previous airway equipment storage. Hospital operating rooms and equipment storage rooms. Simulated difficult airway scenarios without patient involvement. Difficult airway equipment 5S process. Total pieces and cost of airway equipment before and after intervention. Walking distance and time to retrieve equipment, setup equipment, and setup defect rate during a simulation. Previously, airway equipment was stored in 4 locations which was reduced a single difficult airway cart. The total pieces of equipment stored was reduced 89% and the cost of disposable equipment inventory was reduced 81%. Simulations looking at the acquisition and setup of equipment during a difficult airway scenario revealed a 39% reduction in equipment set up time, a 77% reduction in non-valued-added set up time, and a 74% reduction in walking distance. There was no difference in set up defect rates. Application of this lean method resulted in a revised single cart with equipment pared down to only what is needed, arranged according to frequency and order of use in a difficult airway. In a simulated difficult airway, there was a reduction in non-value-added time and walking distance to retrieve the equipment. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Experiments Program for NASA's Space Communications Testbed

    Science.gov (United States)

    Chelmins, David; Reinhart, Richard

    2012-01-01

    NASA developed a testbed for communications and navigation that was launched to the International Space Station in 2012. The testbed promotes new software defined radio (SDR) technologies and addresses associated operational concepts for space-based SDRs, enabled by this first flight of NASA's Space Telecommunications Radio System (STRS) architecture standard. The experiments program consists of a mix of in-house and external experiments from partners in industry, academia, and government. The experiments will investigate key challenges in communications, networking, and global positioning system navigation both on the ground and on orbit. This presentation will discuss some of the key opportunities and challenges for the testbed experiments program.

  18. Des guides et des cartes

    Directory of Open Access Journals (Sweden)

    Patricia MATHIEU

    1987-12-01

    Full Text Available Consultés pour leurs références régionales ou locales, les guides touristiques donnent aussi une vision globale de la France qui est rarement perçue par l'utilisateur. Différents types de représentations cartographiques ont été choisis pour montrer, à partir d'informations simples, découpage en «régions» touristiques, étoilement des sites et des espaces touristiques, cette image de la France.

  19. Versatile Electric Propulsion Aircraft Testbed Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An all-electric aircraft testbed is proposed to provide a dedicated development environment for the rigorous study and advancement of electrically powered aircraft....

  20. AMS San Diego Testbed - Calibration Data

    Data.gov (United States)

    Department of Transportation — The data in this repository were collected from the San Diego, California testbed, namely, I-15 from the interchange with SR-78 in the north to the interchange with...

  1. Habitat Testbed (HaT) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Goals of the DSH Testbed include:Function as a habitat systems integrator and technology pull across many domainsDevelop and integrate software-based models of...

  2. Wireless Sensor Networks TestBed: ASNTbed

    CSIR Research Space (South Africa)

    Dludla, AG

    2013-05-01

    Full Text Available Wireless sensor networks (WSNs) have been used in different types of applications and deployed within various environments. Simulation tools are essential for studying WSNs, especially for exploring large-scale networks. However, WSN testbeds...

  3. Implementation of standard testbeds for numerical relativity

    Energy Technology Data Exchange (ETDEWEB)

    Babiuc, M C [Department of Physics and Physical Science, Marshall University, Huntington, WV 25755 (United States); Husa, S [Friedrich Schiller University Jena, Max-Wien-Platz 1, 07743 Jena (Germany); Alic, D [Department of Physics, University of the Balearic Islands, Cra Valldemossa km 7.5, 07122 Palma de Mallorca (Spain); Hinder, I [Center for Gravitational Wave Physics, Pennsylvania State University, University Park, PA 16802 (United States); Lechner, C [Weierstrass Institute for Applied Analysis and Stochastics (WIAS), Mohrenstrasse 39, 10117 Berlin (Germany); Schnetter, E [Center for Computation and Technology, 216 Johnston Hall, Louisiana State University, Baton Rouge, LA 70803 (United States); Szilagyi, B; Dorband, N; Pollney, D; Winicour, J [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut), Am Muehlenberg 1, 14076 Golm (Germany); Zlochower, Y [Center for Computational Relativity and Gravitation, School of Mathematical Sciences, Rochester Institute of Technology, 78 Lomb Memorial Drive, Rochester, New York 14623 (United States)

    2008-06-21

    We discuss results that have been obtained from the implementation of the initial round of testbeds for numerical relativity which was proposed in the first paper of the Apples with Apples Alliance. We present benchmark results for various codes which provide templates for analyzing the testbeds and to draw conclusions about various features of the codes. This allows us to sharpen the initial test specifications, design a new test and add theoretical insight.

  4. Service by a Queue and a Cart

    OpenAIRE

    E. G. Coffman, Jr.; Gilbert, E.N.

    1992-01-01

    Items arrive randomly at a production facility that functions as a single-server queueing system. The items might represent parts, raw material, etc. and the server might be a factory worker or a machine in a production line. Following service, items are placed in a buffer where they are accumulated before delivery to a customer or some downstream activity in a production line. In practice, the buffer might be called a hopper; it may take the form of a cart or a pallet moved by a forklift. Fo...

  5. The DataTAG transatlantic testbed

    CERN Document Server

    Martin, O; Martin-Flatin, J P; Moroni, P; Nae, D; Newman, H; Ravot, S

    2005-01-01

    Wide area network testbeds allow researchers and engineers to test out new equipment, protocols and services in real-life situations, without jeopardizing the stability and reliability of production networks. The Data TransAtlantic Grid (DataTAG) testbed, deployed in 2002 between CERN, Geneva, Switzerland and StarLight, Chicago, IL, USA, is probably the largest testbed built to date. Jointly managed by CERN and Caltech, it is funded by the European Commission, the U.S. Department of Energy and the U.S. National Science Foundation. The main objectives of this testbed are to improve the Grid community's understanding of the networking issues posed by data- intensive Grid applications over transoceanic gigabit networks, design and develop new Grid middleware services, and improve the interoperability of European and U.S. Grid applications in High- Energy and Nuclear Physics. In this paper, we give an overview of this testbed, describe its various topologies over time, and summarize the main lessons learned after...

  6. La Carte du Ciel vue de Potsdam

    Science.gov (United States)

    Bigg, C.

    2008-06-01

    Ce chapitre s'attache à retracer les aléas de la Carte du Ciel depuis l'Observatoire de Potsdam. Le cas de cet établissement sert de point de comparaison avec les observatoires français, en particulier en ce qui concerne l'organisation du travail au sein de l'Observatoire et le problème de la répartition des ressources humaines et instrumentales dans la poursuite de ce projet de longue haleine. On remarque notamment que si les astronomes allemands, héritiers d'une tradition d'excellence en astrométrie stellaire, se devaient de prendre part à la "Photographische Himmelskarte", ce ne sont pas les observatoires d'astronomie classique mais le nouvel observatoire d'astrophysique de Potsdam qui entreprendra cette tâche. Les études effectuées dans ce cadre sur la photographie stellaire et surtout la photométrie photographique seront ainsi considérées comme des contributions à la jeune science astrophysique - du moins jusqu'à ce que la Carte du Ciel entre en concurrence dans l'Observatoire avec les projets de catalogues de spectres stellaires et de mesure des vitesses radiales.

  7. Um corpo de cartógrafo

    Directory of Open Access Journals (Sweden)

    Flavia Liberman

    2015-03-01

    Full Text Available A cartografia tem sido discutida no Brasil como um método em pesquisa que pressupõe uma reversão metodológica na qual o caminhar na pesquisa antecede a definição de metas a serem alcançadas. Este texto busca contribuir para as discussões sobre a formação do cartógrafo, considerando que, para se realizar uma pesquisa na perspectiva cartográfica, é preciso um corpo que mobilize algumas qualidades, como: atenção, presença, disponibilidade, sensibilidade, entre outras. Ao aproximar nossa experiência teórico-prática do pensamento de autores ligados à filosofia da diferença e das ideias de Keleman e Favre sobre temáticas que envolvem o corpo, buscou-se sistematizar algumas guias para a construção de um corpo de cartógrafo, que pudessem servir de orientação na pesquisa, na prática profissional e nos processos de ensino-aprendizagem. Ao longo do texto, procuramos pensar a construção de dispositivos que promovam encontros plasmados por afetos e acontecimentos.

  8. Exploration Systems Health Management Facilities and Testbed Workshop

    Science.gov (United States)

    Wilson, Scott; Waterman, Robert; McCleskey, Carey

    2004-01-01

    Presentation Agenda : (1) Technology Maturation Pipeline (The Plan) (2) Cryogenic testbed (and other KSC Labs) (2a) Component / Subsystem technologies (3) Advanced Technology Development Center (ATDC) (3a) System / Vehic1e technologies (4) EL V Flight Experiments (Flight Testbeds).

  9. Development of a Tethered Formation Flight Testbed for ISS Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The development of a testbed for the development and demonstration of technologies needed by tethered formation flying satellites is proposed. Such a testbed would...

  10. The Planets Testbed: Science for Digital Preservation

    Directory of Open Access Journals (Sweden)

    Seamus Ross

    2008-06-01

    Full Text Available The preservation of digital objects requires specific software tools or services. These can be characterisation tools that abstract the essential characteristics of a digital object from a file, migration tools that convert digital objects to different formats, or emulation tools that render digital objects in their original context on a new infrastructure. Until recently digital preservation has been characterised by practices and processes that could best be described as more art and craft than science. The Planets Testbed provides a controlled environment where preservation tools can be tested and evaluated, and where experiment results can be empirically compared. This paper presents an overview of the Testbed application, an analysis of the experiment methodology and a description of the Testbed's web service approach.

  11. (DURIP) MIMO Radar Testbed for Waveform Adaptive Sensing Research

    Science.gov (United States)

    2015-06-17

    SDR ) testbed. The testbed consists of 14 micro SDR platforms with two transmit and one receive antennas and a standalone SDR with 4 transmit and 4...receive channels multiplexed to 32 x 32 antenna array through a switching matrix. These SDR platforms can adaptively modify both transmit waveforms... SDR ) testbed. The testbed consists of 14 micro SDR platforms with two transmit and one receive antennas and a standalone SDR with 4 transmit and 4

  12. Simulation at the point of care: reduced-cost, in situ training via a mobile cart.

    Science.gov (United States)

    Weinstock, Peter H; Kappus, Liana J; Garden, Alexander; Burns, Jeffrey P

    2009-03-01

    The rapid growth of simulation in health care has challenged traditional paradigms of hospital-based education and training. Simulation addresses patient safety through deliberative practice of high-risk low-frequency events within a safe, structured environment. Despite its inherent appeal, widespread adoption of simulation is prohibited by high cost, limited space, interruptions to clinical duties, and the inability to replicate important nuances of clinical environments. We therefore sought to develop a reduced-cost low-space mobile cart to provide realistic simulation experiences to a range of providers within the clinical environment and to serve as a model for transportable, cost-effective, widespread simulation-based training of bona-fide workplace teams. Descriptive study. A tertiary care pediatric teaching hospital. A self-contained mobile simulation cart was constructed at a cost of $8054 (mannequin not included). The cart is compatible with any mannequin and contains all equipment needed to produce a high quality simulation experience equivalent to that of our on-site center--including didactics and debriefing with videotaped recordings complete with vital sign overlay. Over a 3-year period the cart delivered 57 courses to 425 participants from five pediatric departments. All individuals were trained among their native teams and within their own clinical environment. By bringing all pedagogical elements to the actual clinical environment, a mobile cart can provide simulation to hospital teams that might not otherwise benefit from the educational tool. By reducing the setup cost and the need for dedicated space, the mobile approach provides a mechanism to increase the number of institutions capable of harnessing the power of simulation-based education internationally.

  13. Towards a testbed for malicious code detection

    Energy Technology Data Exchange (ETDEWEB)

    Lo, R.; Kerchen, P.; Crawford, R.; Ho, W.; Crossley, J.; Fink, G.; Levitt, K.; Olsson, R.; Archer, M. (California Univ., Davis, CA (USA). Div. of Computer Science)

    1991-01-01

    This paper proposes an environment for detecting many types of malicious code, including computer viruses, Trojan horses, and time/logic bombs. This malicious code testbed (MCT) is based upon both static and dynamic analysis tools developed at the University of California, Davis, which have been shown to be effective against certain types of malicious code. The testbed extends the usefulness of these tools by using them in a complementary fashion to detect more general cases of malicious code. Perhaps more importantly, the MCT allows administrators and security analysts to check a program before installation, thereby avoiding any damage a malicious program might inflict. 5 refs., 2 figs., 2 tabs.

  14. Final report for the project "Improving the understanding of surface-atmosphere radiative interactions by mapping surface reflectance over the ARM CART site" (award DE-FG02-02ER63351)

    Energy Technology Data Exchange (ETDEWEB)

    Alexander P. Trishchenko; Yi Luo; Konstantin V. Khlopenkov, William M. Park; Zhanqing Li; Maureen Cribb

    2008-11-28

    Surface spectral reflectance (albedo) is a fundamental variable affecting the transfer of solar radiation and the Earth’s climate. It determines the proportion of solar energy absorbed by the surface and reflected back to the atmosphere. The International Panel on Climate Change (IPCC) identified surface albedo among key factors influencing climate radiative forcing. Accurate knowledge of surface reflective properties is important for advancing weather forecasting and climate change impact studies. It is also important for determining radiative impact and acceptable levels of greenhouse gases in the atmosphere, which makes this work strongly linked to major scientific objectives of the Climate Change Research Division (CCRD) and Atmospheric Radiation Measurement (ARM) Program. Most significant accomplishments of eth project are listed below. I) Surface albedo/BRDF datasets from 1995 to the end of 2004 have been produced. They were made available to the ARM community and other interested users through the CCRS public ftp site ftp://ftp.ccrs.nrcan.gc.ca/ad/CCRS_ARM/ and ARM IOP data archive under “PI data Trishchenko”. II) Surface albedo properties over the ARM SGP area have been described for 10-year period. Comparison with ECMWF data product showed some deficiencies in the ECMWF surface scheme, such as missing some seasonal variability and no dependence on sky-conditions which biases surface energy budget and has some influence of the diurnal cycle of upward radiation and atmospheric absorption. III) Four surface albedo Intensive Observation Period (IOP) Field Campaigns have been conducted for every season (August, 2002, May 2003, February 2004 and October 2004). Data have been prepared, documented and transferred to ARM IOP archive. Nine peer-reviewed journal papers and 26 conference papers have been published.

  15. Wireless sensor network testbed: A gateway for future solutions

    CSIR Research Space (South Africa)

    Abu-Mahfouz, Adnan M

    2012-10-01

    Full Text Available MI2T-WSN is a multi-level infrastructure of interconnected testbeds of large-scale WSNs. MI2T-WSN consists of 1000 sensor motes that will be distributed into four different testbeds. The variations of these testbeds will allow for the implemention...

  16. CART in the Regulation of Appetite and Energy Homeostasis

    Directory of Open Access Journals (Sweden)

    Jackie eLau

    2014-10-01

    Full Text Available The cocaine- and amphetamine-regulated transcript (CART has been the subject of significant interest for over a decade. Work to decipher the detailed mechanism of CART function has been hampered by the lack of specific pharmacological tools like antagonists and the absence of a specific CART receptor(s. However, extensive research has been devoted to elucidate the role of the CART peptide and it is now evident that CART is a key neurotransmitter and hormone involved in the regulation of diverse biological processes, including food intake, maintenance of body weight, reward and addiction, stress response, psychostimulant effects and endocrine functions1,2. In this review, we focus on knowledge gained on CART’s role in controlling appetite and energy homeostasis, and also address certain species differences between rodents and humans.

  17. Evaluation of the New York City Green Carts program

    Directory of Open Access Journals (Sweden)

    Shannon M Farley

    2015-12-01

    Full Text Available Access to fresh fruits and vegetables is a concern, particularly among low-income populations. Mobile vending is one strategy to expand produce availability and access to increase consumption. In 2008, New York City launched a mobile vending initiative, Green Carts. We report on the evaluation. Three waves of cross-sectional observational surveys of produce availability, variety, and quality were conducted during the summers of 2008, 2009, and 2011 in a stratified random sample of stores and carts comparing establishments in Green Cart neighborhoods (n = 13 with comparison neighborhoods (n = 3. Bivariate analyses for availability, variety, and quality comparing Green Cart and comparison neighborhoods were presented across years, and logistic and negative binomial regressions were used to test whether fruit and vegetable availability, variety, and quality increased in Green Cart compared with comparison neighborhoods, adjusting for clustering and neighborhood demographics. Establishments selling fruits and vegetables in Green Cart neighborhoods increased between 2008 and 2011 (50% to 69%, p <0.0001; there was no comparable increase in comparison neighborhoods. Establishments selling more than 10 fruits and vegetables types increased from 31% to 38% (p = 0.0414 in Green Cart neighborhoods; there was no change in comparison neighborhoods. Produce quality was high among comparison establishments, with 95% and 94% meeting the quality threshold in 2008 and 2011, while declining in Green Cart neighborhood establishments from 96% to 88% (p < 0.0001. Sustained produce availability was found in Green Cart neighborhoods between 2008–2011. Green Carts are one strategy contributing to improving produce access among New Yorkers.

  18. Automatic Integration Testbeds validation on Open Science Grid

    Science.gov (United States)

    Caballero, J.; Thapa, S.; Gardner, R.; Potekhin, M.

    2011-12-01

    A recurring challenge in deploying high quality production middleware is the extent to which realistic testing occurs before release of the software into the production environment. We describe here an automated system for validating releases of the Open Science Grid software stack that leverages the (pilot-based) PanDA job management system developed and used by the ATLAS experiment. The system was motivated by a desire to subject the OSG Integration Testbed to more realistic validation tests. In particular those which resemble to every extent possible actual job workflows used by the experiments thus utilizing job scheduling at the compute element (CE), use of the worker node execution environment, transfer of data to/from the local storage element (SE), etc. The context is that candidate releases of OSG compute and storage elements can be tested by injecting large numbers of synthetic jobs varying in complexity and coverage of services tested. The native capabilities of the PanDA system can thus be used to define jobs, monitor their execution, and archive the resulting run statistics including success and failure modes. A repository of generic workflows and job types to measure various metrics of interest has been created. A command-line toolset has been developed so that testbed managers can quickly submit "VO-like" jobs into the system when newly deployed services are ready for testing. A system for automatic submission has been crafted to send jobs to integration testbed sites, collecting the results in a central service and generating regular reports for performance and reliability.

  19. La carte des 36 000 communes

    Directory of Open Access Journals (Sweden)

    Aliette DELAMARRE

    1989-12-01

    Full Text Available La carte généralisée du maillage communal français, obtenue à partir d'un sondage spatial au quart, met en évidence des modèles régionaux caractérisés par des mailles inégalement fines. Cette division du territoire, héritée de la trame paroissiale, a été mise en mémoire par la création, en 1789, de l'institution communale. Seuls les travaux de géographie historique permettront de découvrir les mécanismes de sa mise en place à dater des Xe-XIe, voire des VIe et VIIe siècles.

  20. Building a Desktop Search Test-Bed

    NARCIS (Netherlands)

    Chernov, Sergey; Serdyukov, Pavel; Chirita, Paul-Alexandru; Demartini, Gianluca; Nejdl, Wolfgang

    In the last years several top-quality papers utilized temporary Desktop data and/or browsing activity logs for experimental evaluation. Building a common testbed for the Personal Information Management community is thus becoming an indispensable task. In this paper we present a possible dataset

  1. A Laboratory Testbed for Embedded Fuzzy Control

    Science.gov (United States)

    Srivastava, S.; Sukumar, V.; Bhasin, P. S.; Arun Kumar, D.

    2011-01-01

    This paper presents a novel scheme called "Laboratory Testbed for Embedded Fuzzy Control of a Real Time Nonlinear System." The idea is based upon the fact that project-based learning motivates students to learn actively and to use their engineering skills acquired in their previous years of study. It also fosters initiative and focuses…

  2. SSERVI Analog Regolith Simulant Testbed Facility

    Science.gov (United States)

    Minafra, J.; Schmidt, G. K.

    2016-12-01

    SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers. The SSERVI Analog Regolith Simulant Testbed provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment. The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area. SSERVI provides a bridge between several groups, joining together researchers from: 1) scientific and exploration communities, 2) multiple disciplines across a wide range of planetary sciences, and 3) domestic and international communities and partnerships. This testbed provides a means of consolidating the tasks of acquisition, storage and safety mitigation in handling large quantities of regolith simulant Facility hardware and environment testing scenarios include, but are not limited to the following; Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, and Surface features (i.e. grades and rocks) Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and planetary exploration activities at NASA Research Park, to academia and expanded commercial opportunities in California's Silicon Valley, as well as public outreach and education opportunities.

  3. A Business-to-Business Interoperability Testbed: An Overview

    Energy Technology Data Exchange (ETDEWEB)

    Kulvatunyou, Boonserm [ORNL; Ivezic, Nenad [ORNL; Monica, Martin [Sun Microsystems, Inc.; Jones, Albert [National Institute of Standards and Technology (NIST)

    2003-10-01

    In this paper, we describe a business-to-business (B2B) testbed co-sponsored by the Open Applications Group, Inc. (OAGI) and the National Institute of Standard and Technology (NIST) to advance enterprise e-commerce standards. We describe the business and technical objectives and initial activities within the B2B Testbed. We summarize our initial lessons learned to form the requirements that drive the next generation testbed development. We also give an overview of a promising testing framework architecture in which to drive the testbed developments. We outline the future plans for the testbed development.

  4. Embedded Data Processor and Portable Computer Technology testbeds

    Science.gov (United States)

    Alena, Richard; Liu, Yuan-Kwei; Goforth, Andre; Fernquist, Alan R.

    1993-01-01

    Attention is given to current activities in the Embedded Data Processor and Portable Computer Technology testbed configurations that are part of the Advanced Data Systems Architectures Testbed at the Information Sciences Division at NASA Ames Research Center. The Embedded Data Processor Testbed evaluates advanced microprocessors for potential use in mission and payload applications within the Space Station Freedom Program. The Portable Computer Technology (PCT) Testbed integrates and demonstrates advanced portable computing devices and data system architectures. The PCT Testbed uses both commercial and custom-developed devices to demonstrate the feasibility of functional expansion and networking for portable computers in flight missions.

  5. CMS Test of the European DataGrid Testbed

    CERN Document Server

    Biasotto, Massimo; Capiluppi, Paolo; Charlot, Claude; Colling, David; MacEvoy, Barry C; Tallini, Hugh; Corvo, Marco; Fanzago, Federica; Verlato, Marco; Fanfani, Alessandra; Fantinel, Sergio; Gaillac, Anne-Marie; Grandi, Claudio; Augustin, I; Lefébure, Véronique; Stockinger, Heinz; Maroney, Owen; Nebrensky, H; Semeniouk, Igor; Blaising, J J; Burke, Samuel; Chierici, A; Cavalli, A; Ciaschini, V; Field, L; Groep, D; Hernández, F; Italiano, A; Kunszt, Peter Z; Lajili, N; Laure, Erwin; Leonardi, Emanuele; Loomis, C; Prelz, F; Reale, M; Schulz, M; Sciabà, Andrea; Sgaravatto, Massimo; Templon, J A; Tortone, G

    2003-01-01

    Starting in the middle of November 2002, the CMS experiment undertook an evaluation of the European, DataGrid Project (EDG) middleware using its event simulation programs. A joint CMS-EDG task force performed a iestress testle by submitting a large number of jobs to many distributed sites. The EDG testbed was complemented with additional CMS-dedicated resources. A total of ~ 10000 jobs consisting of two different computational types were submitted from four different locations in Europe over a period of about one month. Nine sites were active, providing integrated resources of more than 500 CPUs and about 5 TB of disk space (with the additional use of two Mass Storage Systems). Detailed descriptions of the adopted procedures, the problems encountered and the corresponding solutions are reported. Results and evaluations of the test, both from the CMS and the EDG perspectives, are described (Version 2).

  6. HEP Applications Evaluation of the EDG Testbed and Middleware

    CERN Document Server

    Augustin, I; Closier, J; van Herwijnen, E; Blaising, J J; Boutigny, D; Charlot, C; Garonne, V; Tsaregorodtsev, A; Bos, K; Templon, J; Capiluppi, P; Fanfani, A; Barbera, R; Negri, G; Perini, L; Resconi, S; Sitta, M; Reale, M; Vicinanza, D; Bagnasco, S; Cerello, P; Sciaba, A; Smirnova, O; Colling, D; Harris, F; Burke, Stephen

    2003-01-01

    Workpackage 8 of the European Datagrid project was formed in January 2001 with representatives from the four LHC experiments, and with experiment independent people from five of the six main EDG partners. In September 2002 WP8 was strengthened by the addition of effort from BaBar and D0. The original mandate of WP8 was, following the definition of short- and long-term requirements, to port experiment software to the EDG middleware and testbed environment. A major additional activity has been testing the basic functionality and performance of this environment. This paper reviews experiences and evaluations in the areas of job submission, data management, mass storage handling, information systems and monitoring. It also comments on the problems of remote debugging, the portability of code, and scaling problems with increasing numbers of jobs, sites and nodes. Reference is made to the pioneeering work of Atlas and CMS in integrating the use of the EDG Testbed into their data challenges. A forward look is made t...

  7. RAMAN LIDAR PROFILING OF WATER VAPOR AND AEROSOLS OVER THE ARM SGP SITE.

    Energy Technology Data Exchange (ETDEWEB)

    FERRARE,R.A.

    2000-01-09

    We have developed and implemented automated algorithms to retrieve profiles of water vapor mixing ratio, aerosol backscattering, and aerosol extinction from Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) Raman Lidar data acquired during both daytime and nighttime operations. This Raman lidar system is unique in that it is turnkey, automated system designed for unattended, around-the-clock profiling of water vapor and aerosols (Goldsmith et al., 1998). These Raman lidar profiles are important for determining the clear-sky radiative flux, as well as for validating the retrieval algorithms associated with satellite sensors. Accurate, high spatial and temporal resolution profiles of water vapor are also required for assimilation into mesoscale models to improve weather forecasts. We have also developed and implemented routines to simultaneously retrieve profiles of relative humidity. These routines utilize the water vapor mixing ratio profiles derived from the Raman lidar measurements together with temperature profiles derived from a physical retrieval algorithm that uses data from a collocated Atmospheric Emitted Radiance Interferometer (AERI) and the Geostationary Operational Environmental Satellite (GOES) (Feltz et al., 1998; Turner et al., 1999). These aerosol and water vapor profiles (Raman lidar) and temperature profiles (AERI+GOES) have been combined into a single product that takes advantage of both active and passive remote sensors to characterize the clear sky atmospheric state above the CART site.

  8. Raman lidar profiling of water vapor and aerosols over the ARM SGP Site

    Energy Technology Data Exchange (ETDEWEB)

    Ferrare, R.A.

    2000-01-09

    The authors have developed and implemented automated algorithms to retrieve profiles of water vapor mixing ratio, aerosol backscattering, and aerosol extinction from Southern Great Plains (SGP) Cloud and Radiation Testbed (CART) Raman Lidar data acquired during both daytime and nighttime operations. The Raman lidar sytem is unique in that it is turnkey, automated system designed for unattended, around-the-clock profiling of water vapor and aerosols. These Raman lidar profiles are important for determining the clear-sky radiative flux, as well as for validating the retrieval algorithms associated with satellite sensors. Accurate, high spatial and temporal resolution profiles of water vapor are also required for assimilation into mesoscale models to improve weather forecasts. The authors have also developed and implemented routines to simultaneously retrieve profiles of relative humidity. These routines utilize the water vapor mixing ratio profiles derived from the Raman lidar measurements together with temperature profiles derived from a physical retrieval algorithm that uses data from a collocated Atmospheric Emitted Radiance Interferometer (AERI) and the Geostationary Operational Environmental Satellite (GOES). These aerosol and water vapor profiles (Raman lidar) and temperature profiles (AERI+GOES) have been combined into a single product that takes advantage of both active and passive remote sensors to characterize the clear sky atmospheric state above the CART site.

  9. Data assimilation of a ten-day period during June 1993 over the Southern Great Plains Site using a nested mesoscale model

    Energy Technology Data Exchange (ETDEWEB)

    Dudhia, J.; Guo, Y.R. [National Center for Atmospheric Research, Boulder, CO (United States)

    1996-04-01

    A goal of the Atmospheric Radiation Measurement (ARM) Program has been to obtain a complete representation of physical processes on the scale of a general circulation model (GCM) grid box in order to better parameterize radiative processes in these models. Since an observational network of practical size cannot be used alone to characterize the Cloud and Radiation Testbed (CART) site`s 3D structure and time development, data assimilation using the enhanced observations together with a mesoscale model is used to give a full 4D analysis at high resolution. The National Center for Atmospheric Research (NCAR)/Penn State Mesoscale Model (MM5) has been applied over a ten-day continuous period in a triple-nested mode with grid sizes of 60, 20 and 6.67 in. The outer domain covers the United States` 48 contiguous states; the innermost is a 480-km square centered on Lamont, Oklahoma. A simulation has been run with data assimilation using the Mesoscale Analysis and Prediction System (MAPS) 60-km analyses from the Forecast Systems Laboratory (FSL) of the National Ocean and Atmospheric Administration (NOAA). The nested domains take boundary conditions from and feed back continually to their parent meshes (i.e., they are two-way interactive). As reported last year, this provided a simulation of the basic features of mesoscale events over the CART site during the period 16-26 June 1993 when an Intensive Observation Period (IOP) was under way.

  10. Ejection of a rear facing, golf cart passenger.

    Science.gov (United States)

    Schau, Kyle; Masory, Oren

    2013-10-01

    The following report details the findings of a series of experiments and simulations performed on a commercially available, shuttle style golf cart during several maneuvers involving rapid accelerations of the vehicle. It is determined that the current set of passive restraints on these types of golf carts are not adequate in preventing ejection of a rear facing passenger during rapid accelerations in the forward and lateral directions. Experimental data and simulations show that a hip restraint must be a minimum of 13 in. above the seat in order to secure a rear facing passenger during sharp turns, compared to the current restraint height of 5 in. Furthermore, it is determined that a restraint directly in front of the rear facing passenger is necessary to prevent ejection. In addressing these issues, golf cart manufacturers could greatly reduce the likelihood of injury due to ejection of a rear facing, golf cart passenger. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. CAR-T Cell Therapies From the Transfusion Medicine Perspective.

    Science.gov (United States)

    Fesnak, Andrew; Lin, ChieYu; Siegel, Don L; Maus, Marcela V

    2016-07-01

    The use of chimeric antigen receptor (CAR)-T cell therapy for the treatment of hematologic malignancies has generated significant excitement over the last several years. From a transfusion medicine perspective, the implementation of CAR-T therapy as a potential mainstay treatment for not only hematologic but also solid-organ malignancies represents a significant opportunity for growth and expansion. In this review, we will describe the rationale for the development of genetically redirected T cells as a cancer therapeutic, the different elements that are required to engineer these cells, as well as an overview of the process by which patient cells are harvested and processed to create and subsequently validate CAR-T cells. Finally, we will briefly describe some of the toxicities and clinical efficacy of CAR-T cells in the setting of patients with advanced malignancy. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. Single link flexible beam testbed project. Thesis

    Science.gov (United States)

    Hughes, Declan

    1992-01-01

    This thesis describes the single link flexible beam testbed at the CLaMS laboratory in terms of its hardware, software, and linear model, and presents two controllers, each including a hub angle proportional-derivative (PD) feedback compensator and one augmented by a second static gain full state feedback loop, based upon a synthesized strictly positive real (SPR) output, that increases specific flexible mode pole damping ratios w.r.t the PD only case and hence reduces unwanted residual oscillation effects. Restricting full state feedback gains so as to produce a SPR open loop transfer function ensures that the associated compensator has an infinite gain margin and a phase margin of at least (-90, 90) degrees. Both experimental and simulation data are evaluated in order to compare some different observer performance when applied to the real testbed and to the linear model when uncompensated flexible modes are included.

  13. Cognitive Optical Network Testbed: EU Project CHRON

    DEFF Research Database (Denmark)

    Borkowski, Robert; Duran, Ramon J.; Kachris, Christoforos

    2015-01-01

    The aim of cognition in optical networks is to introduce intelligence into the control plane that allows for autonomous end-to-end performance optimization and minimization of required human intervention, particularly targeted at heterogeneous network scenarios. A cognitive network observes, learns......, and makes informed decisions based on its current status and knowledge about past decisions and their results. To test the operation of cognitive algorithms in real time, we created the first operational testbed of a cognitive optical network based on the Cognitive Heterogeneous Reconfigurable Optical...... Network (CHRON) architecture. In this experiment, an intelligent control plane, enabled by a cognitive decision system (CDS), was successfully combined with a flexible data plane. The testbed was used to test and validate different scenarios, demonstrating benefits obtained by network cognition...

  14. Mechanistic site-based emulation of a global ocean biogeochemical model (MEDUSA 1.0 for parametric analysis and calibration: an application of the Marine Model Optimization Testbed (MarMOT 1.1

    Directory of Open Access Journals (Sweden)

    J. C. P. Hemmings

    2015-03-01

    Full Text Available Biogeochemical ocean circulation models used to investigate the role of plankton ecosystems in global change rely on adjustable parameters to capture the dominant biogeochemical dynamics of a complex biological system. In principle, optimal parameter values can be estimated by fitting models to observational data, including satellite ocean colour products such as chlorophyll that achieve good spatial and temporal coverage of the surface ocean. However, comprehensive parametric analyses require large ensemble experiments that are computationally infeasible with global 3-D simulations. Site-based simulations provide an efficient alternative but can only be used to make reliable inferences about global model performance if robust quantitative descriptions of their relationships with the corresponding 3-D simulations can be established. The feasibility of establishing such a relationship is investigated for an intermediate complexity biogeochemistry model (MEDUSA coupled with a widely used global ocean model (NEMO. A site-based mechanistic emulator is constructed for surface chlorophyll output from this target model as a function of model parameters. The emulator comprises an array of 1-D simulators and a statistical quantification of the uncertainty in their predictions. The unknown parameter-dependent biogeochemical environment, in terms of initial tracer concentrations and lateral flux information required by the simulators, is a significant source of uncertainty. It is approximated by a mean environment derived from a small ensemble of 3-D simulations representing variability of the target model behaviour over the parameter space of interest. The performance of two alternative uncertainty quantification schemes is examined: a direct method based on comparisons between simulator output and a sample of known target model "truths" and an indirect method that is only partially reliant on knowledge of the target model output. In general, chlorophyll

  15. SSERVI Analog Regolith Simulant Testbed Facility

    Science.gov (United States)

    Minafra, Joseph; Schmidt, Gregory; Bailey, Brad; Gibbs, Kristina

    2016-10-01

    The Solar System Exploration Research Virtual Institute (SSERVI) at NASA's Ames Research Center in California's Silicon Valley was founded in 2013 to act as a virtual institute that provides interdisciplinary research centered on the goals of its supporting directorates: NASA Science Mission Directorate (SMD) and the Human Exploration & Operations Mission Directorate (HEOMD).Primary research goals of the Institute revolve around the integration of science and exploration to gain knowledge required for the future of human space exploration beyond low Earth orbit. SSERVI intends to leverage existing JSC1A regolith simulant resources into the creation of a regolith simulant testbed facility. The purpose of this testbed concept is to provide the planetary exploration community with a readily available capability to test hardware and conduct research in a large simulant environment.SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers.SSERVI provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment.The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area, including dust mitigation and safety oversight.Facility hardware and environment testing scenarios could include, Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, Surface features (i.e. grades and rocks)Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and

  16. Variable Dynamic Testbed Vehicle: Dynamics Analysis

    Science.gov (United States)

    Lee, A. Y.; Le, N. T.; Marriott, A. T.

    1997-01-01

    The Variable Dynamic Testbed Vehicle (VDTV) concept has been proposed as a tool to evaluate collision avoidance systems and to perform driving-related human factors research. The goal of this study is to analytically investigate to what extent a VDTV with adjustable front and rear anti-roll bar stiffnesses, programmable damping rates, and four-wheel-steering can emulate the lateral dynamics of a broad range of passenger vehicles.

  17. Potential Antidepressant Role of Neurotransmitter CART: Implications for Mental Disorders

    Directory of Open Access Journals (Sweden)

    Peizhong Mao

    2011-01-01

    Full Text Available Depression is one of the most prevalent and debilitating public health concerns. Although no single cause of depression has been identified, it appears that interaction among genetic, epigenetic, biochemical, environmental, and psychosocial factors may explain its etiology. Further, only a fraction of depressed patients show full remission while using current antidepressants. Therefore, identifying common pathways of the disorder and using that knowledge to develop more effective pharmacological treatments are two primary targets of research in this field. Brain-enriched neurotransmitter CART (cocaine- and amphetamine-regulated transcript has multiple functions related to emotions. It is a potential neurotrophic factor and is involved in the regulation of hypothalamic-pituitary-adrenal axis and stress response as well as in energy homeostasis. CART is also highly expressed in limbic system, which is considered to have an important role in regulating mood. Notably, adolescents carrying a missense mutation in the CART gene exhibit increased depression and anxiety. Hence, CART peptide may be a novel promising antidepressant agent. In this paper, we summarize recent progress in depression and CART. In particular, we emphasize a new antidepressant function for CART.

  18. Analysis of performance measures to handle medical E-commerce shopping cart abandonment in cloud

    Directory of Open Access Journals (Sweden)

    Vedhanayagam Priya

    Full Text Available The E-commerce zone is crowded with many Internet users. Medical E-commerce has had significant growth in part because of a great deal of growth in the Indian E-commerce field. Medical E-commerce sites use cloud computing to guarantee a high quality of service anywhere and anytime in the world. For online access, the customer's expectations are very high. Medical E-commerce retailers are directed towards cloud service providers based on their quality of service. During online shopping, impatient customers may abandon a specific medical E-commerce shopping cart due to slow response. This is quite difficult to endure for a medical E-commerce firm. The research described herein observed the effect of shopping cart abandonment on medical E-commerce websites deployed in cloud computing. The impact of the idle virtual machine on customer impatience during medical E-commerce shopping was also studied. The ultimate aim of this study was to propose a stochastic queueing model and to yield results through probability generating functions. The results of the model may be highly useful for a medical E-commerce firm facing customer impatience, so as to design its service system to offer satisfactory quality of service. Keywords: Cloud computing, Queueing, Virtual machine, E-commerce, Cart abandonment, Quality of Service

  19. Aux cartes citoyens. La démocratie par les cartes

    Directory of Open Access Journals (Sweden)

    Anne Chapuis

    2000-11-01

    Full Text Available Les cartes, images puissantes rendant visible et compréhensibles des informations nombreuses et complexes, ont une vocation naturelle à servir de support aux débats sur l'aménagement du territoire et aux actions de développement, et en cela être un des outils privilégiés de la démocratie. Plusieurs expériences au sein de collectivités territoriales en France et au sein d'organismes de développement en Inde nous ont démontré que l'utilisation de cartes et matrices pour l'aide à la décision est le plus souvent jugée dangereuse. Bien construites elles sont révélatrices des déséquilibres spatiaux, des enjeux de pouvoir et bien entendu de la corruption. Nous présentons quelques unes de ces expériences avec en arrière plan les enjeux de la démocratie et de la Transparence tant vantées et si peu pratiquées.

  20. Les voix/voies de la carte

    Directory of Open Access Journals (Sweden)

    Louise Bénat-Tachot

    2012-01-01

    Full Text Available La confection du padrón real par les experts de la Casa de la Contratación de Séville dans la première moitié du XVIe siècle, a été un enjeu majeur non seulement pour établir la nouvelle configuration globale du monde mais aussi pour légitimer les entreprises d’expansion des nations ibériques en affirmant la maîtrise de la navigation. Dans quelle mesure la rédaction des premières chroniques des Indes est-elle liée à cette activité cartographique d’état qui lui est contemporaine ? Les liens épistémologiques, rhétoriques et politiques qui lient ces deux productions seront étudiés à partir de la carte universelle de Diego de Ribeiro et de deux chroniques : celle de Gonzalo Fernández de Oviedo et celle de Francisco López de Gómara.La confección del padrón real por los expertos de la Casa de la Contratación de Sevilla durante la primera mitad del siglo XVI, fue de mayor trascendencia no sólo por cartografiar la nueva configuración del mundo sino también porque legitimaba la empresa de expansión de las naciones ibéricas así como para afirmaba su dominio de la navegación. ¿ En qué medida se vincula la redacción de las primeras crónicas de Indias con esta actividad de estado cartográfica contemporánea ? Los vínculos epistemológicos, retóricos y políticos que unen estas dos producciones serán analizados a partir de la carta universal de Diego de Ribeiro y de las dos crónicas primitivas de Indias : la de Gonzalo Fernández de Oviedo y la de Francisco López de Gómara.

  1. MRMS Experimental Testbed for Operational Products (METOP)

    Science.gov (United States)

    Zhang, J.

    2016-12-01

    Accurate high-resolution quantitative precipitation estimation (QPE) at the continental scale is of critical importance to the nation's weather, water and climate services. To address this need, a Multi-Radar Multi-Sensor (MRMS) system was developed at the National Severe Storms Lab of National Oceanic and Atmospheric Administration that integrates radar, gauge, model and satellite data and provides a suite of QPE products at 1-km and 2-min resolution. MRMS system consists of three components: 1) an operational system; 2) a real-time research system; 3) an archive testbed. The operational system currently provides instantaneous precipitation rate, type and 1- to 72-hr accumulations for conterminous United Stated and southern Canada. The research system has the similar hardware infrastructure and data environment as the operational system, but runs newer and more advanced algorithms. The newer algorithms are tested on the research system for robustness and computational efficiency in a pseudo operational environment before they are transitioned into operations. The archive testbed, also called the MRMS Experimental Testbed for Operational Products (METOP), consists of a large database that encompasses a wide range of hydroclimatological and geographical regimes. METOP is for the testing and refinements of the most advanced radar QPE techniques, which are often developed on specific data from limited times and locations. The archive data includes quality controlled in-situ observations for the validation of the new radar QPE across all seasons and geographic regions. A number of operational QPE products derived from different sensors/models are also included in METOP for the fusion of multiple sources of complementary precipitation information. This paper is an introduction of the METOP system.

  2. Use of Tabu Search in a Solver to Map Complex Networks onto Emulab Testbeds

    National Research Council Canada - National Science Library

    MacDonald, Jason E

    2007-01-01

    The University of Utah's solver for the testbed mapping problem uses a simulated annealing metaheuristic algorithm to map a researcher's experimental network topology onto available testbed resources...

  3. Easy as Pi: A Network Coding Raspberry Pi Testbed

    DEFF Research Database (Denmark)

    W. Sørensen, Chres; Hernandez Marcano, Nestor Javier; Cabrera Guerrero, Juan A.

    2016-01-01

    of the hardware, but also due to maintenance challenges. In this paper, we present the required key steps to design, setup and maintain an inexpensive testbed using Raspberry Pi devices for communications and storage networks with network coding capabilities. This testbed can be utilized for any applications...

  4. Multi-agent testbed for distributed space systems

    NARCIS (Netherlands)

    Osuman, A.; Guo, J.; Gill, E.K.A.

    2010-01-01

    Several industries are involved in the development of distributed systems, testbeds are needed to simulate the real world challenges that face the distributed systems. Presently, there are a number of testbeds in the world with very distinctive characteristics. Delft University of Technology is

  5. Application developer's tutorial for the CSM testbed architecture

    Science.gov (United States)

    Underwood, Phillip; Felippa, Carlos A.

    1988-01-01

    This tutorial serves as an illustration of the use of the programmer interface on the CSM Testbed Architecture (NICE). It presents a complete, but simple, introduction to using both the GAL-DBM (Global Access Library-Database Manager) and CLIP (Command Language Interface Program) to write a NICE processor. Familiarity with the CSM Testbed architecture is required.

  6. New development in CAR-T cell therapy

    Directory of Open Access Journals (Sweden)

    Zhenguang Wang

    2017-02-01

    Full Text Available Abstract Chimeric antigen receptor (CAR-engineered T cells (CAR-T cells have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-ALL with up to a 90% complete remission rate. However, tumor antigen escape has emerged as a main challenge for the long-term disease control of this promising immunotherapy in B cell malignancies. In addition, this success has encountered significant hurdles in translation to solid tumors, and the safety of the on-target/off-tumor recognition of normal tissues is one of the main reasons. In this mini-review, we characterize some of the mechanisms for antigen loss relapse and new strategies to address this issue. In addition, we discuss some novel CAR designs that are being considered to enhance the safety of CAR-T cell therapy in solid tumors.

  7. Object Transportation by Two Mobile Robots with Hand Carts.

    Science.gov (United States)

    Sakuyama, Takuya; Figueroa Heredia, Jorge David; Ogata, Taiki; Hara, Tatsunori; Ota, Jun

    2014-01-01

    This paper proposes a methodology by which two small mobile robots can grasp, lift, and transport large objects using hand carts. The specific problems involve generating robot actions and determining the hand cart positions to achieve the stable loading of objects onto the carts. These problems are solved using nonlinear optimization, and we propose an algorithm for generating robot actions. The proposed method was verified through simulations and experiments using actual devices in a real environment. The proposed method could reduce the number of robots required to transport large objects with 50-60%. In addition, we demonstrated the efficacy of this task in real environments where errors occur in robot sensing and movement.

  8. Simulation and Test of a Fuel Cell Hybrid Golf Cart

    Directory of Open Access Journals (Sweden)

    Jingming Liang

    2014-01-01

    Full Text Available This paper establishes the simulation model of fuel cell hybrid golf cart (FCHGC, which applies the non-GUI mode of the Advanced Vehicle Simulator (ADVISOR and the genetic algorithm (GA to optimize it. Simulation of the objective function is composed of fuel consumption and vehicle dynamic performance; the variables are the fuel cell stack power sizes and the battery numbers. By means of simulation, the optimal parameters of vehicle power unit, fuel cell stack, and battery pack are worked out. On this basis, GUI mode of ADVISOR is used to select the rated power of vehicle motor. In line with simulation parameters, an electrical golf cart is refitted by adding a 2 kW hydrogen air proton exchange membrane fuel cell (PEMFC stack system and test the FCHGC. The result shows that the simulation data is effective but it needs improving compared with that of the real cart test.

  9. Nuclear Instrumentation and Control Cyber Testbed Considerations – Lessons Learned

    Energy Technology Data Exchange (ETDEWEB)

    Jonathan Gray; Robert Anderson; Julio G. Rodriguez; Cheol-Kwon Lee

    2014-08-01

    Abstract: Identifying and understanding digital instrumentation and control (I&C) cyber vulnerabilities within nuclear power plants and other nuclear facilities, is critical if nation states desire to operate nuclear facilities safely, reliably, and securely. In order to demonstrate objective evidence that cyber vulnerabilities have been adequately identified and mitigated, a testbed representing a facility’s critical nuclear equipment must be replicated. Idaho National Laboratory (INL) has built and operated similar testbeds for common critical infrastructure I&C for over ten years. This experience developing, operating, and maintaining an I&C testbed in support of research identifying cyber vulnerabilities has led the Korean Atomic Energy Research Institute of the Republic of Korea to solicit the experiences of INL to help mitigate problems early in the design, development, operation, and maintenance of a similar testbed. The following information will discuss I&C testbed lessons learned and the impact of these experiences to KAERI.

  10. Vermeer et les cartes de géographie.

    Directory of Open Access Journals (Sweden)

    Jean MARTINON

    1987-09-01

    Full Text Available De nombreux tableaux de Vermeer sont «tapissés» de cartes de géographie. Objets scientifiques, elles témoignent de l'importance des découvertes au XVIIe siècle en Europe et de l'ouverture des Pays-Bas sur le monde. Objets de décoration, les cartes tendent à se confondre avec des représentations paysagères. Objets romanesques, elles introduisent le lointain et le rêve dans les intérieurs confinés de la bourgeoisie d'Amsterdam.

  11. Fruit Carts: A Domain and Corpus for Research in Dialogue Systems and Psycholinguistics.

    Science.gov (United States)

    Aist, Gregory; Campana, Ellen; Allen, James; Swift, Mary; Tanenhaus, Michael K

    2012-09-01

    We describe a novel domain, Fruit Carts, aimed at eliciting human language production for the twin purposes of (a) dialogue system research and development and (b) psycholinguistic research. Fruit Carts contains five tasks: choosing a cart, placing it on a map, painting the cart, rotating the cart, and filling the cart with fruit. Fruit Carts has been used for research in psycholinguistics and in dialogue systems. Based on these experiences, we discuss how well the Fruit Carts domain meets four desired features: unscripted, context-constrained, controllable difficulty, and separability into semi-independent subdialogues. We describe the domain in sufficient detail to allow others to replicate it; researchers interested in using the corpora themselves are encouraged to contact the authors directly.

  12. Smart Shopping Carts: How Real-Time Feedback Influences Spending

    NARCIS (Netherlands)

    Ittersum, van K.; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly

  13. Smart shopping carts : How real-time feedback influences spending

    NARCIS (Netherlands)

    van Ittersum, Koert; Wansink, B.; Pennings, J.M.E.; Sheehan, D.

    2013-01-01

    Although interest in smart shopping carts is increasing, both retailers and consumer groups have concerns about how real-time spending feedback will influence shopping behavior. Building on budgeting and spending theories, the authors conduct three lab and grocery store experiments that robustly

  14. A New Dynamics Cart on an Inclined Plane.

    Science.gov (United States)

    Theodorsson, Pall

    1995-01-01

    Presents an experiment to study the acceleration of a cart moving up and down an inclined plane. Demonstrates how multitiming and the study of the movement in both directions allows the determination of the component of gravitational force along an inclined plane without any assumptions about friction. (JRH)

  15. Technology Developments Integrating a Space Network Communications Testbed

    Science.gov (United States)

    Kwong, Winston; Jennings, Esther; Clare, Loren; Leang, Dee

    2006-01-01

    As future manned and robotic space explorations missions involve more complex systems, it is essential to verify, validate, and optimize such systems through simulation and emulation in a low cost testbed environment. The goal of such a testbed is to perform detailed testing of advanced space and ground communications networks, technologies, and client applications that are essential for future space exploration missions. We describe the development of new technologies enhancing our Multi-mission Advanced Communications Hybrid Environment for Test and Evaluation (MACHETE) that enable its integration in a distributed space communications testbed. MACHETE combines orbital modeling, link analysis, and protocol and service modeling to quantify system performance based on comprehensive considerations of different aspects of space missions. It can simulate entire networks and can interface with external (testbed) systems. The key technology developments enabling the integration of MACHETE into a distributed testbed are the Monitor and Control module and the QualNet IP Network Emulator module. Specifically, the Monitor and Control module establishes a standard interface mechanism to centralize the management of each testbed component. The QualNet IP Network Emulator module allows externally generated network traffic to be passed through MACHETE to experience simulated network behaviors such as propagation delay, data loss, orbital effects and other communications characteristics, including entire network behaviors. We report a successful integration of MACHETE with a space communication testbed modeling a lunar exploration scenario. This document is the viewgraph slides of the presentation.

  16. The Impact of Verbal Prompts on Child Safety-Belt Use in Shopping Carts

    Science.gov (United States)

    Barker, Mae R.; Bailey, Jon S.; Lee, Natalie

    2004-01-01

    Each year thousands of children are injured by falling from shopping carts. Buckling children into the seats of shopping carts could prevent many of these injuries. A combined reversal and multiple baseline across settings design was used to evaluate the impact of verbal prompts on shopping cart safety-belt use in two stores. Safety-belt use…

  17. Aerodynamic design of the National Rotor Testbed.

    Energy Technology Data Exchange (ETDEWEB)

    Kelley, Christopher Lee [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-10-01

    A new wind turbine blade has been designed for the National Rotor Testbed (NRT) project and for future experiments at the Scaled Wind Farm Technology (SWiFT) facility with a specific focus on scaled wakes. This report shows the aerodynamic design of new blades that can produce a wake that has similitude to utility scale blades despite the difference in size and location in the atmospheric boundary layer. Dimensionless quantities circulation, induction, thrust coefficient, and tip-speed-ratio were kept equal between rotor scales in region 2 of operation. The new NRT design matched the aerodynamic quantities of the most common wind turbine in the United States, the GE 1.5sle turbine with 37c model blades. The NRT blade design is presented along with its performance subject to the winds at SWiFT. The design requirements determined by the SWiFT experimental test campaign are shown to be met.

  18. Lessons from Korea Telecom's VoIP testbed

    Science.gov (United States)

    Lee, Ki Jong; Yang, Junhwan; Kim, Dongkweon

    2001-07-01

    This paper describers the results and lessons from the voice over IP trial service on the Korea Telecom's VoIP Testbed. The testbed was made up of four different vendors' systems and solutions constituted four separate zones. Even though the backbone network of the testbed was not commercial IP network, we could comprehend some engineering parameters essential to packetized voice QoS. And we got some know-how. These kinds of results will be much help to traditional telco confronted with many difficult issues especially on packet voice network.

  19. The Living With a Star Space Environment Testbed Payload

    Science.gov (United States)

    Xapsos, Mike

    2015-01-01

    This presentation outlines a brief description of the Living With a Star (LWS) Program missions and detailed information about the Space Environment Testbed (SET) payload consisting of a space weather monitor and carrier containing 4 board experiments.

  20. Prognostics-Enabled Power Supply for ADAPT Testbed Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Ridgetop's role is to develop electronic prognostics for sensing power systems in support of NASA/Ames ADAPT testbed. The prognostic enabled power systems from...

  1. Implementing Universal Priority DBA Algorithm in PIC based EPON Testbed

    Science.gov (United States)

    Radzi, N. A. M.; Din, N. M.; Al-Mansoori, M. H.; Majid, M. S. A.; Abdullah, F.

    2013-12-01

    Ethernet passive optical network (EPON) is becoming one of the best schemes in the broadband access network as it combines the Ethernet and passive optical network technology. In order to avoid collision in upstream EPON, Universal Dynamic Bandwidth Allocation (UDBA) algorithm is proposed in this paper where it can support a universal priority in the entire EPON system. For proof-of-concept, the UDBA algorithm is implemented inside a proposed peripheral interface controller (PIC) based EPON testbed in order to evaluate the communication protocol involved. To the best of our knowledge, this is the first time PIC is being used in EPON testbed for this purpose. To ensure that the testbed is valid, we compare the result that we achieved via testbed with the results achieved via MATLAB simulation in terms of throughput, delay and fairness. The simulated results show a good agreement with the experimental with some minor expected differences.

  2. Autour d’une carte médicale.

    Directory of Open Access Journals (Sweden)

    Hervé Le Bras

    2008-10-01

    Full Text Available Réaction d’Hervé Le Bras. En jugeant une carte publiée par Ouest-France, Loïc Rivault estime qu’elle est insuffisante parce qu’elle rapporte le nombre d’infirmiers à la population totale. « En effet il faudrait diviser le nombre d’infirmières par rapport aux plus de soixante ou soixante-quinze ans et non à la population totale. Les écarts seraient alors certainement moins importants, car les départements en marrons foncé et clair sont ceux où les personnes âgées sont ...

  3. Méthodologie de Conception de Cartes Rapides Workshop

    CERN Document Server

    2003-01-01

    - Problématique de développement de carte rapide pour l'expérience LHCb(transparents) - Solution basée sur le flot Cadence PSD14.2 de conception de circuits imprimés(CI) rapides (transparents) - Nouveau partage des taches entre l'ingénieur concepteur et le professionnel développeur de CI (transparents) - Démonstration du flot à partir d'un exemple concret pour l'expérience LHCb (Démo 1h min) - Conclusion : Essentiellement pour lancer une discussion sur l'impact de ce nouveau flot de conception Cadence sur la méthode de développement de cartes à l'IN2P3.

  4. Comparing longitudinal CD4 responses to cART among non-perinatally HIV-infected youth versus adults: Results from the HIVRN Cohort.

    Science.gov (United States)

    Agwu, Allison L; Fleishman, John A; Mahiane, Guy; Nonyane, Bareng Aletta Sanny; Althoff, Keri N; Yehia, Baligh R; Berry, Stephen A; Rutstein, Richard; Nijhawan, Ank; Mathews, Christopher; Aberg, Judith A; Keruly, Jeanne C; Moore, Richard D; Gebo, Kelly A

    2017-01-01

    Youth have residual thymic tissue and potentially greater capacity for immune reconstitution than adults after initiation of combination antiretroviral therapy (cART). However, youth face behavioral and psychosocial challenges that may make them more likely than adults to delay ART initiation and less likely to attain similar CD4 outcomes after initiating cART. This study compared CD4 outcomes over time following cART initiation between ART-naïve non-perinatally HIV-infected (nPHIV) youth (13-24 years-old) and adults (≥25-44 years-old). Retrospective analysis of ART-naïve nPHIV individuals 13-44 years-old, who initiated their first cART between 2008 and 2011 at clinical sites in the HIV Research Network. A linear mixed model was used to assess the association between CD4 levels after cART initiation and age (13-24, 25-34, 35-44 years), accounting for random variation within participants and between sites, and adjusting for key variables including gender, race/ethnicity, viral load, gaps in care (defined as > 365 days between CD4 tests), and CD4 levels prior to cART initiation (baseline CD4). Among 2,595 individuals (435 youth; 2,160 adults), the median follow-up after cART initiation was 179 weeks (IQR 92-249). Baseline CD4 was higher for youth (320 cells/mm3) than for ages 25-34 (293) or 35-44 (258). At 239 weeks after cART initiation, median unadjusted CD4 was higher for youth than adults (576 vs. 539 and 476 cells/mm3, respectively), but this difference was not significant when baseline CD4 was controlled. Compared to those with baseline CD4 ≤200 cells/mm3, individuals with baseline CD4 of 201-500 and >500 cells/mm3 had greater predicted CD4 levels: 390, 607, and 831, respectively. Additionally, having no gaps in care and higher viral load were associated with better CD4 outcomes. Despite having residual thymic tissue, youth attain similar, not superior, CD4 gains as adults. Early ART initiation with minimal delay is as essential to optimizing outcomes for

  5. Comparing longitudinal CD4 responses to cART among non-perinatally HIV-infected youth versus adults: Results from the HIVRN Cohort.

    Directory of Open Access Journals (Sweden)

    Allison L Agwu

    Full Text Available Youth have residual thymic tissue and potentially greater capacity for immune reconstitution than adults after initiation of combination antiretroviral therapy (cART. However, youth face behavioral and psychosocial challenges that may make them more likely than adults to delay ART initiation and less likely to attain similar CD4 outcomes after initiating cART. This study compared CD4 outcomes over time following cART initiation between ART-naïve non-perinatally HIV-infected (nPHIV youth (13-24 years-old and adults (≥25-44 years-old.Retrospective analysis of ART-naïve nPHIV individuals 13-44 years-old, who initiated their first cART between 2008 and 2011 at clinical sites in the HIV Research Network. A linear mixed model was used to assess the association between CD4 levels after cART initiation and age (13-24, 25-34, 35-44 years, accounting for random variation within participants and between sites, and adjusting for key variables including gender, race/ethnicity, viral load, gaps in care (defined as > 365 days between CD4 tests, and CD4 levels prior to cART initiation (baseline CD4.Among 2,595 individuals (435 youth; 2,160 adults, the median follow-up after cART initiation was 179 weeks (IQR 92-249. Baseline CD4 was higher for youth (320 cells/mm3 than for ages 25-34 (293 or 35-44 (258. At 239 weeks after cART initiation, median unadjusted CD4 was higher for youth than adults (576 vs. 539 and 476 cells/mm3, respectively, but this difference was not significant when baseline CD4 was controlled. Compared to those with baseline CD4 ≤200 cells/mm3, individuals with baseline CD4 of 201-500 and >500 cells/mm3 had greater predicted CD4 levels: 390, 607, and 831, respectively. Additionally, having no gaps in care and higher viral load were associated with better CD4 outcomes.Despite having residual thymic tissue, youth attain similar, not superior, CD4 gains as adults. Early ART initiation with minimal delay is as essential to optimizing outcomes

  6. Sur l'utilité de la carte en proportions

    Directory of Open Access Journals (Sweden)

    Isabelle DEBEER

    1996-03-01

    Full Text Available Seule la carte en proportions révèle des répartitions de masses. Cette règle élémentaire de cartographie est rappelée ici par un exemple opérationnel: la répartition spatiale des logements chauffés à l'énergie solaire en Belgique.

  7. E-Commerce Performance. Shopping Cart Key Performance Indicators

    OpenAIRE

    Mihaela I. MUNTEAN; Diana TARNAVEANU; Ana Raluca ION

    2016-01-01

    In an e-commerce performance framework is important to identify the key performance indicators that measure success and together provide the greatest context into the business perfor-mance. Shopping carts are an essential part of ecommerce, a minimal set of key performance indicators being the subject of our debate. The theoretical approach is sustained by a case study, an e-shop implemented using PHP and MySQL, for simulating main business processes within the considered performance framewor...

  8. A knowledge based software engineering environment testbed

    Science.gov (United States)

    Gill, C.; Reedy, A.; Baker, L.

    1985-01-01

    The Carnegie Group Incorporated and Boeing Computer Services Company are developing a testbed which will provide a framework for integrating conventional software engineering tools with Artifical Intelligence (AI) tools to promote automation and productivity. The emphasis is on the transfer of AI technology to the software development process. Experiments relate to AI issues such as scaling up, inference, and knowledge representation. In its first year, the project has created a model of software development by representing software activities; developed a module representation formalism to specify the behavior and structure of software objects; integrated the model with the formalism to identify shared representation and inheritance mechanisms; demonstrated object programming by writing procedures and applying them to software objects; used data-directed and goal-directed reasoning to, respectively, infer the cause of bugs and evaluate the appropriateness of a configuration; and demonstrated knowledge-based graphics. Future plans include introduction of knowledge-based systems for rapid prototyping or rescheduling; natural language interfaces; blackboard architecture; and distributed processing

  9. Optical testbed for the LISA phasemeter

    Science.gov (United States)

    Schwarze, T. S.; Fernández Barranco, G.; Penkert, D.; Gerberding, O.; Heinzel, G.; Danzmann, K.

    2016-05-01

    The planned spaceborne gravitational wave detector LISA will allow the detection of gravitational waves at frequencies between 0.1 mHz and 1 Hz. A breadboard model for the metrology system aka the phasemeter was developed in the scope of an ESA technology development project by a collaboration between the Albert Einstein Institute, the Technical University of Denmark and the Danish industry partner Axcon Aps. It in particular provides the electronic readout of the main interferometer phases besides auxiliary functions. These include clock noise transfer, ADC pilot tone correction, inter-satellite ranging and data transfer. Besides in LISA, the phasemeter can also be applied in future satellite geodesy missions. Here we show the planning and advances in the implementation of an optical testbed for the full metrology chain. It is based on an ultra-stable hexagonal optical bench. This bench allows the generation of three unequal heterodyne beatnotes with a zero phase combination, thus providing the possibility to probe the phase readout for non-linearities in an optical three signal test. Additionally, the utilization of three independent phasemeters will allow the testing of the auxiliary functions. Once working, components can individually be replaced with flight-qualified hardware in this setup.

  10. Termite: Emulation Testbed for Encounter Networks

    Directory of Open Access Journals (Sweden)

    Rodrigo Bruno

    2015-08-01

    Full Text Available Cutting-edge mobile devices like smartphones and tablets are equipped with various infrastructureless wireless interfaces, such as WiFi Direct and Bluetooth. Such technologies allow for novel mobile applications that take advantage of casual encounters between co-located users. However, the need to mimic the behavior of real-world encounter networks makes testing and debugging of such applications hard tasks. We present Termite, an emulation testbed for encounter networks. Our system allows developers to run their applications on a virtual encounter network emulated by software. Developers can model arbitrary encounter networks and specify user interactions on the emulated virtual devices. To facilitate testing and debugging, developers can place breakpoints, inspect the runtime state of virtual nodes, and run experiments in a stepwise fashion. Termite defines its own Petri Net variant to model the dynamically changing topology and synthesize user interactions with virtual devices. The system is designed to efficiently multiplex an underlying emulation hosting infrastructure across multiple developers, and to support heterogeneous mobile platforms. Our current system implementation supports virtual Android devices communicating over WiFi Direct networks and runs on top of a local cloud infrastructure. We evaluated our system using emulator network traces, and found that Termite is expressive and performs well.

  11. Further progress in watermark evaluation testbed (WET)

    Science.gov (United States)

    Kim, Hyung C.; Lin, Eugene T.; Guitart, Oriol; Delp, Edward J., III

    2005-03-01

    While Digital Watermarking has received much attention in recent years, it is still a relatively young technology. There are few accepted tools/metrics that can be used to evaluate the suitability of a watermarking technique for a specific application. This lack of a universally adopted set of metrics/methods has motivated us to develop a web-based digital watermark evaluation system called the Watermark Evaluation Testbed or WET. There have been more improvements over the first version of WET. We implemented batch mode with a queue that allows for user submitted jobs. In addition to StirMark 3.1 as an attack module, we added attack modules based on StirMark 4.0. For a new image fidelity measure, we evaluate conditional entropy as an image fidelity measure for different watermarking algorithms and different attacks. Also, we show the results of curve fitting the Receiver Operating Characteristic (ROC) analysis data using the Parzen window density estimation. The curve fits the data closely while having only two parameters to estimate.

  12. CryoCart Restoration and Vacuum Pipe Construction

    Science.gov (United States)

    Chaidez, Mariana

    2016-01-01

    first completed at the component level. During this process, the igniter of the main engine and the RCS thrusters will be tested under a vacuum. To complete the testing of the components, the test setup first needed to be finalized. The CryoCart is being used to feed the propellants to the test article. The CryoCart is a movable test set-up that was developed in 2009 to provide a mobile platform for testing oxygen/methane systems with hot-fire capability up to 100 lbf. The CryoCart consists of three different systems: Oxygen, Methane, and liquid Nitrogen. The Oxygen and Methane systems are placed into two different carts while the liquid nitrogen system is mainly located in the methane cart. Over the years, the CryoCart has been utilized for different projects and has undergone deterioration. For this reason, a new phase has been developed to rebuild it to working conditions once again. During my internship, I was aiding in the construction and restoration of the CryoCart. In the initial stages of the process, I updated the fluid and electrical schematics for the oxygen, methane, and test article systems. The original CryoCart consisted of an electrical panel that utilized electromechanical relays and a terminal to drive the igniter power and signal, as well as the main fuel and oxygen valves. This electrical panel connected to the CryoCart through various wire harnesses that could be found exiting from the CryoCart. First, it was determined how these harnesses connected to the electromechanical relays so that they worked correctly. Once the electrical system was understood, an alternative for the electromechanical relays and the Molex connectors used throughout the system was sought since these components can often prove to be unreliable. Solid State relays and MIL connectors were purchased to serve as replacements. Upon arrival of the parts, crimping and wiring was completed to install the new solid state relays and MIL connectors. During the replacement of the relays

  13. Advanced turboprop testbed systems study. Volume 1: Testbed program objectives and priorities, drive system and aircraft design studies, evaluation and recommendations and wind tunnel test plans

    Science.gov (United States)

    Bradley, E. S.; Little, B. H.; Warnock, W.; Jenness, C. M.; Wilson, J. M.; Powell, C. W.; Shoaf, L.

    1982-01-01

    The establishment of propfan technology readiness was determined and candidate drive systems for propfan application were identified. Candidate testbed aircraft were investigated for testbed aircraft suitability and four aircraft selected as possible propfan testbed vehicles. An evaluation of the four candidates was performed and the Boeing KC-135A and the Gulfstream American Gulfstream II recommended as the most suitable aircraft for test application. Conceptual designs of the two recommended aircraft were performed and cost and schedule data for the entire testbed program were generated. The program total cost was estimated and a wind tunnel program cost and schedule is generated in support of the testbed program.

  14. In-Space Networking on NASA's SCAN Testbed

    Science.gov (United States)

    Brooks, David E.; Eddy, Wesley M.; Clark, Gilbert J.; Johnson, Sandra K.

    2016-01-01

    The NASA Space Communications and Navigation (SCaN) Testbed, an external payload onboard the International Space Station, is equipped with three software defined radios and a flight computer for supporting in-space communication research. New technologies being studied using the SCaN Testbed include advanced networking, coding, and modulation protocols designed to support the transition of NASAs mission systems from primarily point to point data links and preplanned routes towards adaptive, autonomous internetworked operations needed to meet future mission objectives. Networking protocols implemented on the SCaN Testbed include the Advanced Orbiting Systems (AOS) link-layer protocol, Consultative Committee for Space Data Systems (CCSDS) Encapsulation Packets, Internet Protocol (IP), Space Link Extension (SLE), CCSDS File Delivery Protocol (CFDP), and Delay-Tolerant Networking (DTN) protocols including the Bundle Protocol (BP) and Licklider Transmission Protocol (LTP). The SCaN Testbed end-to-end system provides three S-band data links and one Ka-band data link to exchange space and ground data through NASAs Tracking Data Relay Satellite System or a direct-to-ground link to ground stations. The multiple data links and nodes provide several upgradable elements on both the space and ground systems. This paper will provide a general description of the testbeds system design and capabilities, discuss in detail the design and lessons learned in the implementation of the network protocols, and describe future plans for continuing research to meet the communication needs for evolving global space systems.

  15. CART treatment improves memory and synaptic structure in APP/PS1 mice.

    Science.gov (United States)

    Jin, Jia-li; Liou, Anthony K F; Shi, Yejie; Yin, Kai-lin; Chen, Ling; Li, Ling-ling; Zhu, Xiao-lei; Qian, Lai; Yang, Rong; Chen, Jun; Xu, Yun

    2015-05-11

    Major characteristics of Alzheimer's disease (AD) include deposits of β-amyloid (Aβ) peptide in the brain, loss of synapses, and cognitive dysfunction. Cocaine- and amphetamine-regulated transcript (CART) has recently been reported to attenuate Aβ-induced toxicity. In this study, CART localization in APP/PS1 mice was characterized and the protective effects of exogenous CART treatment were examined. Compared to age-matched wild type mice, 8-month-old APP/PS1 mice had significantly greater CART immunoreactivity in the hippocampus and cortex. A strikingly similar pattern of Aβ plaque-associated CART immunoreactivity was observed in the cortex of AD cases. Treatment of APP/PS1 mice with exogenous CART ameliorated memory deficits; this effect was associated with improvements in synaptic ultrastructure and long-term potentiation, but not a reduction of the Aβ plaques. Exogenous CART treatment in APP/PS1 mice prevented depolarization of the mitochondrial membrane and stimulated mitochondrial complex I and II activities, resulting in an increase in ATP levels. CART treatment of APP/PS1 mice also reduced reactive oxygen species and 4-hydroxynonenal, and mitigated oxidative DNA damage. In summary, CART treatment reduced multiple neuropathological measures and improved memory in APP/PS1 mice, and may therefore be a promising and novel therapy for AD.

  16. Laser Metrology in the Micro-Arcsecond Metrology Testbed

    Science.gov (United States)

    An, Xin; Marx, D.; Goullioud, Renaud; Zhao, Feng

    2004-01-01

    The Space Interferometer Mission (SIM), scheduled for launch in 2009, is a space-born visible light stellar interferometer capable of micro-arcsecond-level astrometry. The Micro-Arcsecond Metrology testbed (MAM) is the ground-based testbed that incorporates all the functionalities of SIM minus the telescope, for mission-enabling technology development and verification. MAM employs a laser heterodyne metrology system using the Sub-Aperture Vertex-to-Vertex (SAVV) concept. In this paper, we describe the development and modification of the SAVV metrology launchers and the metrology instrument electronics, precision alignments and pointing control, locating cyclic error sources in the MAM testbed and methods to mitigate the cyclic errors, as well as the performance under the MAM performance metrics.

  17. A test-bed modeling study for wave resource assessment

    Science.gov (United States)

    Yang, Z.; Neary, V. S.; Wang, T.; Gunawan, B.; Dallman, A.

    2016-02-01

    Hindcasts from phase-averaged wave models are commonly used to estimate standard statistics used in wave energy resource assessments. However, the research community and wave energy converter industry is lacking a well-documented and consistent modeling approach for conducting these resource assessments at different phases of WEC project development, and at different spatial scales, e.g., from small-scale pilot study to large-scale commercial deployment. Therefore, it is necessary to evaluate current wave model codes, as well as limitations and knowledge gaps for predicting sea states, in order to establish best wave modeling practices, and to identify future research needs to improve wave prediction for resource assessment. This paper presents the first phase of an on-going modeling study to address these concerns. The modeling study is being conducted at a test-bed site off the Central Oregon Coast using two of the most widely-used third-generation wave models - WaveWatchIII and SWAN. A nested-grid modeling approach, with domain dimension ranging from global to regional scales, was used to provide wave spectral boundary condition to a local scale model domain, which has a spatial dimension around 60km by 60km and a grid resolution of 250m - 300m. Model results simulated by WaveWatchIII and SWAN in a structured-grid framework are compared to NOAA wave buoy data for the six wave parameters, including omnidirectional wave power, significant wave height, energy period, spectral width, direction of maximum directionally resolved wave power, and directionality coefficient. Model performance and computational efficiency are evaluated, and the best practices for wave resource assessments are discussed, based on a set of standard error statistics and model run times.

  18. E-Commerce Performance. Shopping Cart Key Performance Indicators

    Directory of Open Access Journals (Sweden)

    Mihaela I. MUNTEAN

    2016-01-01

    Full Text Available In an e-commerce performance framework is important to identify the key performance indicators that measure success and together provide the greatest context into the business perfor-mance. Shopping carts are an essential part of ecommerce, a minimal set of key performance indicators being the subject of our debate. The theoretical approach is sustained by a case study, an e-shop implemented using PHP and MySQL, for simulating main business processes within the considered performance framework. Our approach opens a perspective for future research using additional indicators in order to properly evaluate the global performance of any e-shop.

  19. The Living With a Star Space Environment Testbed Program

    Science.gov (United States)

    Barth, Janet; LaBel, Kenneth; Day, John H. (Technical Monitor)

    2001-01-01

    NASA has initiated the Living with a Star (LWS) Program to develop the scientific understanding to address the aspects of the Connected Sun-Earth system that affects life and society. The Program Architecture includes science missions, theory and modeling and Space Environment Testbeds (SET). This current paper discusses the Space Environment Testbeds. The goal of the SET program is to improve the engineering approach to accomodate and/or mitigate the effects of solar variability on spacecraft design and operations. The SET Program will infuse new technologies into the space programs through collection of data in space and subsequent design and validation of technologies. Examples of these technologies are cited and discussed.

  20. Towards a Perpetual Sensor Network Testbed without Backchannel

    DEFF Research Database (Denmark)

    Johansen, Aslak; Bonnet, Philippe; Sørensen, Thomas

    2012-01-01

    The sensor network testbeds available today rely on a communication channel different from the mote radio - a backchannel - to facilitate mote reprogramming, health monitoring and performance analysis. Such backchannels are either supported as wired communication channels (USB or Ethernet), or via...... an extra board coupled to the mote under test and thus introduce significant constraint on the testbed setup and on the mote power budget. With Greenlab, we wish to study the performance behavior of outdoor sensor networks where energy is harvested from the environment. We thus cannot rely on a backchannel...... participating in a user-defined experiment. We evaluate performance by analyzing the overhead our approach introduces....

  1. Design and Analysis of FKSI Nulling Interferometry Testbed

    Science.gov (United States)

    Wilson, Mark; Crooke, Julie; Howard, Joseph; Martino, Anthony; Danchi, William

    2004-01-01

    The Fourier Kelvin Stellar Interferometer is a space borne mission whose purpose is to validate the existence of previously detected Extra Solar Giant Planets (EGP's) and determine the age and primary atmospheric constituents of these EGP's. It consists of 2 collecting telescopes followed by a Mach Zehnder interferometer working in a wavelength range of 3-8 microns. To support this concept, a testbed is being built at NASA Goddard Space Flight Center to demonstrate feasibility of achieving the required nulling ratio (10e-4) across the waveband. This paper describes the design and performance analysis of the testbed. Considerations such as polarization, pupil overlap, and optical path length control are discussed.

  2. Delay Tolerant Networking on NASA's Space Communication and Navigation Testbed

    Science.gov (United States)

    Johnson, Sandra; Eddy, Wesley

    2016-01-01

    This presentation covers the status of the implementation of an open source software that implements the specifications developed by the CCSDS Working Group. Interplanetary Overlay Network (ION) is open source software and it implements specifications that have been developed by two international working groups through IETF and CCSDS. ION was implemented on the SCaN Testbed, a testbed located on an external pallet on ISS, by the GRC team. The presentation will cover the architecture of the system, high level implementation details, and issues porting ION to VxWorks.

  3. Birmanie-Thaïlande: un écart croissant

    Directory of Open Access Journals (Sweden)

    Michel BRUNEAU

    1991-03-01

    Full Text Available Deux royaumes (Birmanie et Siam très proches l’un de l’autre culturellement et dans leurs structures socio-politiques ont vu, au cours des deux siècles derniers, leur richesse économique relative s’inverser l’un par rapport à l’autre en fonction de leur degré d’intégration au commerce international et au capitalisme occidental. Depuis la seconde guerre mondiale, l’écart n’a cessé de se creuser en faveur de la Thaïlande, qui est en train de rejoindre les Nouveaux Pays Industriels. Une cartographie de synthèse montre l’alternance de la richesse économique et l’écart qui n’a cessé de se creuser. L’Asie du Sud-Est continentale naguère déchirée, écartelée par les dominations extérieures (impérialismes britannique et français, puis nippo-américain a tendance à se recomposer en un ensemble dominé par la Thaïlande qui s’affirme de plus en plus comme la puissance économique centrale de la péninsule indochinoise.

  4. Changes in RANKL during the first two years after cART initiation in HIV-infected cART naïve adults

    DEFF Research Database (Denmark)

    Mathiesen, Inger Hee Mabuza; Salem, Mohammad; Gerstoft, Jan

    2017-01-01

    BACKGROUND: By assessing the changes in concentration of soluble receptor activator of nuclear factor κ B ligand (RANKL) and osteoprotegrin (OPG) after initiation of combination antiretroviral therapy (cART) in treatment-naïve HIV-infected patients we aimed to evaluate whether the initial...... accelerated bone loss could be mediated by increased soluble RANKL (sRANKL) levels associated with CD4+ T cell recovery. METHODS: We used multiplex immunoassays to determine sRANKL and OPG concentrations in plasma from 48 HIV patients at baseline and 12, 24, 48 and 96 weeks after cART initiation. RESULTS...... and changes in sRANKL. CONCLUSION: In this study there was no indication that the accelerated bone loss after cART initiation was mediated by early changes in sRANKL due to CD4+ T cell recovery. Future studies should focus on the initial weeks after initiation of cART. TRIAL REGISTRATION: Clinical...

  5. Operation Duties on the F-15B Research Testbed

    Science.gov (United States)

    Truong, Samson S.

    2010-01-01

    This presentation entails what I have done this past summer for my Co-op tour in the Operations Engineering Branch. Activities included supporting the F-15B Research Testbed, supporting the incoming F-15D models, design work, and other operations engineering duties.

  6. Torpedo and countermeasures modelling in the Torpedo Defence System Testbed

    NARCIS (Netherlands)

    Benders, F.P.A.; Witberg, R.R.; H.J. Grootendorst, H.J.

    2002-01-01

    Several years ago, TNO-FEL started the development of the Torpedo Defence System Testbed (TDSTB) based on the TORpedo SIMulation (TORSIM) model and the Maritime Operations Simulation and Evaluation System (MOSES). MOSES provides the simulation and modelling environment for the evaluation and

  7. CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria.

    Directory of Open Access Journals (Sweden)

    Peizhong Mao

    Full Text Available The multifunctional neuropeptide Cocaine and Amphetamine Regulated Transcript (CART is secreted from hypothalamus, pituitary, adrenal gland and pancreas. It also can be found in circulatory system. This feature suggests a general role for CART in different cells. In the present study, we demonstrate that CART protects mitochondrial DNA (mtDNA, cellular proteins and lipids against the oxidative action of hydrogen peroxide, a widely used oxidant. Using cis-parinaric acid as a sensitive reporting probe for peroxidation in membranes, and a lipid-soluble azo initiator of peroxyl radicals, 2,2'-azobis(2,4-dimethylvaleronitrile we found that CART is an antioxidant. Furthermore, we found that CART localized to mitochondria in cultured cells and mouse brain neuronal cells. More importantly, pretreatment with CART by systemic injection protects against a mouse oxidative stress model, which mimics the main features of Parkinson's disease. Given the unique molecular structure and biological features of CART, we conclude that CART is an antioxidant peptide (or antioxidant hormone. We further propose that it may have strong therapeutic properties for human diseases in which oxidative stress is strongly involved such as Parkinson's disease.

  8. Schoolchildren's Consumption of Competitive Foods and Beverages, Excluding a la Carte

    Science.gov (United States)

    Kakarala, Madhuri; Keast, Debra R.; Hoerr, Sharon

    2010-01-01

    Background: Competitive foods/beverages are those in school vending machines, school stores, snack bars, special sales, and items sold a la carte in the school cafeteria that compete with United States Department of Agriculture (USDA) meal program offerings. Grouping a la carte items with less nutritious items allowed in less regulated venues may…

  9. Riding in shopping carts and exposure to raw meat and poultry products: prevalence of, and factors associated with, this risk factor for salmonella and campylobacter infection in children younger than 3 years.

    Science.gov (United States)

    Patrick, Mary E; Mahon, Barbara E; Zansky, Shelley M; Hurd, Sharon; Scallan, Elaine

    2010-06-01

    Riding in a shopping cart next to raw meat or poultry is a risk factor for Salmonella and Campylobacter infections in infants. To describe the frequency of, and factors associated with, this behavior, we surveyed parents of children aged younger than 3 years in Foodborne Disease Active Surveillance Network sites. We defined exposure as answering yes to one of a series of questions asking if packages of raw meat or poultry were near a child in a shopping cart, or if a child was in the cart basket at the same time as was raw meat or poultry. Among 1,273 respondents, 767 (60%) reported that their children visited a grocery store in the past week and rode in shopping carts. Among these children, 103 (13%) were exposed to raw products. Children who rode in the baskets were more likely to be exposed than were those who rode only in the seats (odds ratio [OR], 17.8; 95% confidence interval [CI], 11.0 to 28.9). In a multivariate model, riding in the basket (OR, 15.5; 95% CI, 9.2 to 26.1), income less than $55,000 (OR, 1.8; 95% CI, 1.0 to 3.1), and Hispanic ethnicity (OR, 2.3; 95% CI, 1.2 to 4.5) were associated with exposure. Our study shows that children can be exposed to raw meat and poultry products while riding in shopping carts. Parents should separate children from raw products and place children in the seats rather than in the baskets of the cart. Retailer use of leak-proof packaging, customer placement of product in a plastic bag and on the rack underneath the cart, use of hand sanitizers and wipes, and consumer education may also be helpful.

  10. Pediatric shopping-cart-related injuries treated in US emergency departments, 1990-2011.

    Science.gov (United States)

    Martin, Keith J; Chounthirath, Thiphalak; Xiang, Huiyun; Smith, Gary A

    2014-03-01

    This study investigates the effect of the 2004 US shopping cart safety standard on shopping-cart-related injuries among children younger than 15 years of age by retrospectively analyzing data from the National Electronic Injury Surveillance System. An estimated 530 494 children younger than 15 years were treated in US emergency departments for shopping-cart-related injuries from 1990 to 2011, averaging 24 113 children annually. The most commonly injured body region was the head (78.1%). The annual concussion/closed head injury rate per 10 000 children increased significantly (P shopping cart safety standard was implemented in the United States in 2004, the overall number and rate of injuries associated with shopping carts have not decreased. In fact, the number and rate of concussions/closed head injuries have continued to climb. Increased prevention efforts are needed to address these injuries among children.

  11. Association of Cocaine- and Amphetamine-Regulated Transcript (CART) Messenger RNA Level, Food Intake, and Growth in Channel Catfish

    Science.gov (United States)

    Cocaine-and Amphetamine-Regulated Transcript (CART) is a potent hypothalamic anorectic peptide in mammals and fish. We hypothesized that increased food intake is associated with changes in expression of CART mRNA within the brain of channel catfish. Objectives were to clone the CART gene, examine ...

  12. Different Subsets of T Cells, Memory, Effector Functions, and CAR-T Immunotherapy

    Directory of Open Access Journals (Sweden)

    Vita Golubovskaya

    2016-03-01

    Full Text Available This review is focused on different subsets of T cells: CD4 and CD8, memory and effector functions, and their role in CAR-T therapy––a cellular adoptive immunotherapy with T cells expressing chimeric antigen receptor. The CAR-T cells recognize tumor antigens and induce cytotoxic activities against tumor cells. Recently, differences in T cell functions and the role of memory and effector T cells were shown to be important in CAR-T cell immunotherapy. The CD4+ subsets (Th1, Th2, Th9, Th17, Th22, Treg, and Tfh and CD8+ memory and effector subsets differ in extra-cellular (CD25, CD45RO, CD45RA, CCR-7, L-Selectin [CD62L], etc.; intracellular markers (FOXP3; epigenetic and genetic programs; and metabolic pathways (catabolic or anabolic; and these differences can be modulated to improve CAR-T therapy. In addition, CD4+ Treg cells suppress the efficacy of CAR-T cell therapy, and different approaches to overcome this suppression are discussed in this review. Thus, next-generation CAR-T immunotherapy can be improved, based on our knowledge of T cell subsets functions, differentiation, proliferation, and signaling pathways to generate more active CAR-T cells against tumors.

  13. Meta-CART: A tool to identify interactions between moderators in meta-analysis.

    Science.gov (United States)

    Li, Xinru; Dusseldorp, Elise; Meulman, Jacqueline J

    2017-02-01

    In the framework of meta-analysis, moderator analysis is usually performed only univariately. When several study characteristics are available that may account for treatment effect, standard meta-regression has difficulties in identifying interactions between them. To overcome this problem, meta-CART has been proposed: an approach that applies classification and regression trees (CART) to identify interactions, and then subgroup meta-analysis to test the significance of moderator effects. The previous version of meta-CART has its shortcomings: when applying CART, the sample sizes of studies are not taken into account, and the effect sizes are dichotomized around the median value. Therefore, this article proposes new meta-CART extensions, weighting study effect sizes by their accuracy, and using a regression tree to avoid dichotomization. In addition, new pruning rules are proposed. The performance of all versions of meta-CART was evaluated via a Monte Carlo simulation study. The simulation results revealed that meta-regression trees with random-effects weights and a 0.5-standard-error pruning rule perform best. The required sample size for meta-CART to achieve satisfactory performance depends on the number of study characteristics, the magnitude of the interactions, and the residual heterogeneity. © 2017 The British Psychological Society.

  14. Development of a Testbed for Wireless Underground Sensor Networks

    Directory of Open Access Journals (Sweden)

    Mehmet C. Vuran

    2010-01-01

    Full Text Available Wireless Underground Sensor Networks (WUSNs constitute one of the promising application areas of the recently developed wireless sensor networking techniques. WUSN is a specialized kind of Wireless Sensor Network (WSN that mainly focuses on the use of sensors that communicate through soil. Recent models for the wireless underground communication channel are proposed but few field experiments were realized to verify the accuracy of the models. The realization of field WUSN experiments proved to be extremely complex and time-consuming in comparison with the traditional wireless environment. To the best of our knowledge, this is the first work that proposes guidelines for the development of an outdoor WUSN testbed with the goals of improving the accuracy and reducing of time for WUSN experiments. Although the work mainly aims WUSNs, many of the presented practices can also be applied to generic WSN testbeds.

  15. Evolution of a Simulation Testbed into an Operational Tool

    Science.gov (United States)

    Sheth, Kapil; Bilimoria, Karl D.; Sridhar, Banavar; Sterenchuk, Mike; Niznik, Tim; O'Neill, Tom; Clymer, Alexis; Gutierrez Nolasco, Sebastian; Edholm, Kaj; Shih, Fu-Tai

    2017-01-01

    This paper describes the evolution over a 20-year period of the Future ATM (Air Traffic Management) Concepts Evaluation Tool (FACET) from a National Airspace System (NAS) based simulation testbed into an operational tool. FACET was developed as a testbed for assessing futuristic ATM concepts, e.g., automated conflict detection and resolution. NAS Constraint Evaluation and Notification Tool (NASCENT) is an application, within FACET, for alerting airspace users of inefficiencies in flight operations and advising time- and fuel-saving reroutes.It is currently in use at American Airlines Integrated Operations Center in Fort Worth, TX. The concepts assessed,research conducted, and the operational capability developed, along with the NASA support and achievements are presented in this paper.

  16. A MIMO-OFDM Testbed for Wireless Local Area Networks

    Directory of Open Access Journals (Sweden)

    Conrat Jean-Marc

    2006-01-01

    Full Text Available We describe the design steps and final implementation of a MIMO OFDM prototype platform developed to enhance the performance of wireless LAN standards such as HiperLAN/2 and 802.11, using multiple transmit and multiple receive antennas. We first describe the channel measurement campaign used to characterize the indoor operational propagation environment, and analyze the influence of the channel on code design through a ray-tracing channel simulator. We also comment on some antenna and RF issues which are of importance for the final realization of the testbed. Multiple coding, decoding, and channel estimation strategies are discussed and their respective performance-complexity trade-offs are evaluated over the realistic channel obtained from the propagation studies. Finally, we present the design methodology, including cross-validation of the Matlab, C++, and VHDL components, and the final demonstrator architecture. We highlight the increased measured performance of the MIMO testbed over the single-antenna system.

  17. FDIR Validation Test-Bed Development and Results

    Science.gov (United States)

    Karlsson, Alexander; Sakthivel, Anandhavel; Aberg, Martin; Andersson, Jan; Habinc, Sandi; Dellandrea, Brice; Nodet, Jean-Christian; Guettache, Farid; Furano, Gianluca

    2015-09-01

    This paper describes work being performed by Cobham Gaisler and Thales Alenia Space France for the European Space Agency to develop an extension of the existing avionics system testbed facility in ESTEC's Avionics Lab. The work is funded by the European Space Agency under contract 4000109928/13/NL/AK. The resulting FDIR (Fault Detection, Isolation and Recovery) testbed will allow to test concepts, strategy mechanisms and tools related to FDIR. The resulting facility will have the capabilities to support nominal and off-nominal test cases and to support tools for post testing and post simulation analysis. Ultimately the purpose of the output of this activity is to provide a tool for assessment and validation at laboratory level. This paper describes an on-going development; at the time of writing the activity is in the validation phase.

  18. Development of a FDIR Validation Test-Bed

    Science.gov (United States)

    Andersson, Jan; Cederman, Daniel; Habinc, Sandi; Dellandrea, Brice; Nodet, Jean-Christian; Guettache, Farid; Furano, Gianluca

    2014-08-01

    This paper describes work being performed by Aeroflex Gaisler and Thales Alenia Space France for the European Space Agency to develop an extension of the existing avionics system testbed facility in ESTEC's Avionics Lab. The work is funded by the European Space Agency under contract 4000109928/13/NL/AK.The resulting FDIR (Fault Detection, Isolation and Recovery) testbed will allow to test concepts, strategy mechanisms and tools related to FDIR. The resulting facility will have the capabilities to support nominal and off-nominal test cases and to support tools for post testing and post simulation analysis. Ultimately the purpose of the output of this activity is to provide a tool for assessment and validation at laboratory level.This paper describes an on-going development; at the time of writing the activity is in the preliminary design phase.

  19. Amplitude variations on the Extreme Adaptive Optics testbed

    Energy Technology Data Exchange (ETDEWEB)

    Evans, J; Thomas, S; Dillon, D; Gavel, D; Phillion, D; Macintosh, B

    2007-08-14

    High-contrast adaptive optics systems, such as those needed to image extrasolar planets, are known to require excellent wavefront control and diffraction suppression. At the Laboratory for Adaptive Optics on the Extreme Adaptive Optics testbed, we have already demonstrated wavefront control of better than 1 nm rms within controllable spatial frequencies. Corresponding contrast measurements, however, are limited by amplitude variations, including those introduced by the micro-electrical-mechanical-systems (MEMS) deformable mirror. Results from experimental measurements and wave optic simulations of amplitude variations on the ExAO testbed are presented. We find systematic intensity variations of about 2% rms, and intensity variations with the MEMS to be 6%. Some errors are introduced by phase and amplitude mixing because the MEMS is not conjugate to the pupil, but independent measurements of MEMS reflectivity suggest that some error is introduced by small non-uniformities in the reflectivity.

  20. Satellite Testbed for Evaluating Cryogenic-Liquid Behavior in Microgravity

    Science.gov (United States)

    Putman, Philip Travis (Inventor)

    2017-01-01

    Provided is a testbed for conducting an experiment on a substance in a cryogenic liquid state in a microgravity environment. The testbed includes a frame with rectangular nominal dimensions, and a source section including a supply of the substance to be evaluated in the cryogenic liquid state. An experiment section includes an experiment vessel in fluid communication with the storage section to receive the substance from the storage section and condense the substance into the cryogenic liquid state. A sensor is adapted to sense a property of the substance in the cryogenic liquid state in the experiment vessel as part of the experiment. A bus section includes a controller configured to control delivery of the substance from the storage section to the experiment vessel, and receive property data indicative of the property sensed by the sensor for subsequent evaluation on Earth.

  1. Corée du Nord : la carte et la pomme (de la discorde ?)

    OpenAIRE

    Tratnjek, Bénédicte

    2013-01-01

    Bénédicte Tratnjek, 2013, " Corée du Nord : la carte et la pomme (de la discorde ?) ", Cafés géographiques, rubrique " Brèves de comptoir ", 25 avril 2013, en ligne : http://cafe-geo.net/coree-du-nord-la-carte-et-la-pomme-de-la-discorde/; Edito pour les Cafés géographiques : approche critique des commentaires médiatiques autour des photographies montrant des cartes dévoilant des "secrets" militaires sur des photographies officielles de Kim Jong-Li.

  2. Innovative Varied-Fidelity Simulation Mobile Teaching Cart and Education Project.

    Science.gov (United States)

    Harding, Andrew D; Cullinane Whalen, Kathryn; Silverman, Bradley S

    2015-09-01

    The use of a varied-fidelity simulation mobile teaching cart is a teaching tool that offers unique advantages in the acute care setting. The cart is used to demonstrate the use of patient monitoring devices, and there are a variety of software tools available with the monitoring technology to ensure that the outputs, including electrocardiographic waves, are analyzed appropriately by nursing staff using this varied-fidelity simulation mobile teaching cart. Bringing varied-fidelity simulation to the nurses' work area is a unique application setting. Copyright © 2015 Emergency Nurses Association. Published by Elsevier Inc. All rights reserved.

  3. Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension

    Directory of Open Access Journals (Sweden)

    I. Janiuk

    2015-04-01

    Full Text Available Recent biological advances make it possible to discover new peptides associated with hypertension. The cocaine- and amphetamine-regulated transcript (CART is a known factor in appetite and feeding behaviour. Various lines of evidence suggest that this peptide participates not only in control of feeding behaviour but also in the regulation of the cardiovascular and sympathetic systems and blood pressure. The role of CART in blood pressure regulation led us to undertake a study aimed at analysing quantitative changes in CART-containing cells in urinary bladders (UB of rats with renovascular hypertension. We used the Goldblatt model of arterial hypertension (two-kidney, one clip to evaluate quantitative changes. This model provides researchers with a commonly used tool to analyse the renin-angiotensin system of blood pressure control and, eventually, to develop drugs for the treatment of chronic hypertension. The study was performed on sections of urinary bladders of rats after 3-, 14-, 28-, 42 and 91 days from hypertension induction. Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals. CART was detected in the endocrine cells, especially numerous in the submucosa and muscularis layers, with a few found in the transitional epithelium and only occasionally in serosa. Hypertension significantly increased the number of CART-positive cells in the rat UBs. After 3 and 42 days following the procedure, statistically significantly higher numbers of CART-positive cells were identified in comparison with the control animals. The differences between the hypertensive rats and the control animals concerned not only the number density of CART-immunoreactive cells but also their localization. After a 6-week period, each of the rats subjected to the renal artery clipping procedure developed stable hypertension. CART appeared in numerous transitional epithelium cells. As this study provides novel findings

  4. A technical description of the FlexHouse Project Testbed

    DEFF Research Database (Denmark)

    Sørensen, Jens Otto

    2000-01-01

    This paper describes the FlexHouse project testbed; a server dedicated to experiments within the FlexHouse project. The FlexHouse project is a project originating from The Business Computing Research Group at The Aarhus School of Business. The purpose of the project is to identify and develop...... methods that satisfy the following three requirements. Flexibility with respect to evolving data sources. Flexibility with respect to change of information needs. Efficiency with respect to view management....

  5. Fading testbed for free-space optical communications

    Science.gov (United States)

    Shrestha, Amita; Giggenbach, Dirk; Mustafa, Ahmad; Pacheco-Labrador, Jorge; Ramirez, Julio; Rein, Fabian

    2016-10-01

    Free-space optical (FSO) communication is a very attractive technology offering very high throughput without spectral regulation constraints, yet allowing small antennas (telescopes) and tap-proof communication. However, the transmitted signal has to travel through the atmosphere where it gets influenced by atmospheric turbulence, causing scintillation of the received signal. In addition, climatic effects like fogs, clouds and rain also affect the signal significantly. Moreover, FSO being a line of sight communication requires precise pointing and tracking of the telescopes, which otherwise also causes fading. To achieve error-free transmission, various mitigation techniques like aperture averaging, adaptive optics, transmitter diversity, sophisticated coding and modulation schemes are being investigated and implemented. Evaluating the performance of such systems under controlled conditions is very difficult in field trials since the atmospheric situation constantly changes, and the target scenario (e.g. on aircraft or satellites) is not easily accessible for test purposes. Therefore, with the motivation to be able to test and verify a system under laboratory conditions, DLR has developed a fading testbed that can emulate most realistic channel conditions. The main principle of the fading testbed is to control the input current of a variable optical attenuator such that it attenuates the incoming signal according to the loaded power vector. The sampling frequency and mean power of the vector can be optionally changed according to requirements. This paper provides a brief introduction to software and hardware development of the fading testbed and measurement results showing its accuracy and application scenarios.

  6. ATLAS and CMS applications on the WorldGrid testbed

    CERN Document Server

    Ciaschini, V; Fanzago, F; Verlato, M; Vaccarossa, L; Donno, F; Garbellotto, V

    2003-01-01

    WorldGrid is an intercontinental testbed spanning Europe and the US integrating architecturally different Grid implementations based on the Globus toolkit. It has been developed in the context of the DataTAG and iVDGL projects, and successfully demonstrated during the WorldGrid demos at IST2002 (Copenhagen) and SC2002 (Baltimore). Two HEP experiments, ATLAS and CMS, successful exploited the WorldGrid testbed for executing jobs simulating the response of their detectors to physics eve nts produced by real collisions expected at the LHC accelerator starting from 2007. This data intensive activity has been run since many years on local dedicated computing farms consisting of hundreds of nodes and Terabytes of disk and tape storage. Within the WorldGrid testbed, for the first time HEP simulation jobs were submitted and run indifferently on US and European resources, despite of their underlying different Grid implementations, and produced data which could be retrieved and further analysed on the submitting machine...

  7. Easy as Pi: A Network Coding Raspberry Pi Testbed

    Directory of Open Access Journals (Sweden)

    Chres W. Sørensen

    2016-10-01

    Full Text Available In the near future, upcoming communications and storage networks are expected to tolerate major difficulties produced by huge amounts of data being generated from the Internet of Things (IoT. For these types of networks, strategies and mechanisms based on network coding have appeared as an alternative to overcome these difficulties in a holistic manner, e.g., without sacrificing the benefit of a given network metric when improving another. There has been recurrent issues on: (i making large-scale deployments akin to the Internet of Things; (ii assessing and (iii replicating the obtained results in preliminary studies. Therefore, finding testbeds that can deal with large-scale deployments and not lose historic data in order to evaluate these mechanisms are greatly needed and desirable from a research perspective. However, this can be hard to manage, not only due to the inherent costs of the hardware, but also due to maintenance challenges. In this paper, we present the required key steps to design, setup and maintain an inexpensive testbed using Raspberry Pi devices for communications and storage networks with network coding capabilities. This testbed can be utilized for any applications requiring results replicability.

  8. A Dynamically Reconfigurable Wireless Sensor Network Testbed for Multiple Routing Protocols

    Directory of Open Access Journals (Sweden)

    Wenxian Jiang

    2017-01-01

    Full Text Available Because wireless sensor networks (WSNs are complex and difficult to deploy and manage, appropriate structures are required to make these networks more flexible. In this paper, a reconfigurable testbed is presented, which supports dynamic protocol switching by creating a novel architecture and experiments with several different protocols. The separation of the control and data planes in this testbed means that routing configuration and data transmission are independent. A programmable flow table provides the testbed with the ability to switch protocols dynamically. We experiment on various aspects of the testbed to analyze its functionality and performance. The results demonstrate that sensors in the testbed are easy to manage and can support multiple protocols. We then raise some important issues that should be investigated in future work concerning the testbed.

  9. Demonstration of a Filter Cart for NOx Removal from Ground Support Equipment

    National Research Council Canada - National Science Library

    Canfield, C

    1997-01-01

    ... and effective technology for reducing non-road diesel NOx and other air pollutant emissions. The filter cart was designed to control emissions of NOx, particulate, and unburned hydrocarbons (UHCs...

  10. Carts in a time of transition. As multiple trends shape how clinicians do their work, CIOs ponder the future of mobile carts.

    Science.gov (United States)

    Hagland, Mark

    2010-07-01

    CIOs are actively trying to figure out how to plan for the mobile computing needs of their clinicians in the next several years. Though a broad range of viewpoints prevails across the healthcare system, most CIOs believe they will continue to rely heavily on mobile computing carts to meet clinicians' computing needs within their facilities, even in the face of the emergence of newer, tablet-sized computing devices. Clinician needs and preferences remain paramount considerations as CIOs move to replace sometimes-aging current fleets of computing carts.

  11. To Love—To Live: Barrow and Cart

    Directory of Open Access Journals (Sweden)

    Lisa McDonald

    2013-02-01

    Full Text Available From the residue of meaning, an ensemble of shadows. From the glint of souvenir, pliable impressions. In this paper, we work a poetics of encounter, of being, keeping, homage, of paying homage to fragility, to object and to interspecies—ways are found to engage motion from within and around co-extensive bodies. With the consolation of images, we follow the terse rhythms of routine and street where dwelling is a case of affective dissent. Zones of departure appear through testimony as well as chance, taking their own form. A footfall brings us as observers into quiet spaces which refuse self-estrangement as we travel by way of an unquiet ground. Breath, respiration, aspiration. Precipitation. Sculptures of mist are also the language of lives, of kinship between object, footfall and air. A language of brackets, questions, ellipses. There may be a man, a dog, a barrow. There may be a woman, a cart. Air. How shall this image be made?

  12. CAR-T cell Therapies in Glioblastoma: a first look.

    Science.gov (United States)

    Migliorini, Denis; Dietrich, Pierre-Yves; Stupp, Roger; Linette, Gerald P; Posey, Avery D; June, Carl H

    2017-11-20

    Glioblastoma is an aggressive malignancy with a poor prognosis. The current standard of care for newly diagnosed glioblastoma patients includes surgery to the extent, temozolomide combined with radiotherapy, and alternating electric fields therapy. After recurrence, there is no standard therapy and survival is less than 9 months. Recurrent glioblastoma offers a unique opportunity to investigate new treatment approaches in a malignancy known for remarkable genetic heterogeneity, immunosuppressive microenvironment and partially permissive anatomical blood brain barrier (BBB). Results from three first-in-man CAR-T cell trials targeting IL13Rα2, Her2/CMV and EGFRvIII have recently been reported. Each one of these trials addresses important questions, such as T cell trafficking to CNS, engraftment and persistence, tumor microenvironment (TME) remodeling, and monitoring of glioma response to chimeric antigen receptor (CAR) T cells. Objective radiological responses have been reported. Here, we discuss and summarize the results of these trials and suggest opportunities for the field. Copyright ©2017, American Association for Cancer Research.

  13. Motion sickness in ancient China: Seasickness and cart-sickness.

    Science.gov (United States)

    Brandt, Thomas; Bauer, Matthias; Benson, Judy; Huppert, Doreen

    2016-07-19

    To find and analyze descriptions of motion sickness in Chinese historical sources. Databases and dictionaries were searched for various terms for seasickness and travel sickness, which were then entered into databases of full texts allowing selection of relevant passages from about the third to the 19th century ad. Already in 300 ad the Chinese differentiated cart-sickness, particularly experienced by persons from the arid north of China, from a ship-illness experienced by persons from the south, where rivers were important for transportation and travel. In the Middle Ages, a third form of motion sickness was called litter-influence experienced by persons transported in a bed suspended between 2 long poles. The ancient Chinese recognized the particular susceptibility of children to motion sickness. Therapeutic recommendations include drinking the urine of young boys, swallowing white sand-syrup, collecting water drops from a bamboo stick, or hiding some earth from the middle of the kitchen hearth under the hair. The Chinese medical classics distinguished several forms of travel sickness, all of which had their own written characters. The pathophysiologic mechanism was explained by the medicine of correspondences, which was based on malfunctions within the body, its invasion by external pathogens like wind, or the deficit or surfeit of certain bodily substances such as the life force Qi. The concept of motion as the trigger of sickness initially appeared in a chapter on warding off the influence of demons and corpses, e.g., ancient magic and beliefs. © 2016 American Academy of Neurology.

  14. Intermediate transport in Southeast Asia. [Carts, cycles, mini-buses

    Energy Technology Data Exchange (ETDEWEB)

    Meier, A.K.

    1977-06-01

    Traffic flows through the streets of Southeast Asian countries even though they are used for almost all aspects of human and animal existence. The carts, bicycles, tricycles, and motorcycles, motorized three-wheelers, mini-buses are the so-called intermediate-transport vehicles. It is upon this group of vehicles that a culture--constrained by its own unique economic, environmental, and technological factors--exerts its influence most directly toward the solution of the transport problem. Transportation fills more service roles in Southeast Asian cities than in Western cities. Communication facilities such as telephones and postal services are notoriously unreliable. The personal encounter is all important in social and business interactions in Southeast Asia. Each of the transport modes is examined in view of design and use in a number of specific cultural settings for the countries in Southeast Asia. Present use of intermediate transport in developed countries is discussed briefly, and its further development predicted--pointing out the health and conservation advantages. (MCW)

  15. Page 1 Engineering analysis of the two-wheel bullock cart design ...

    Indian Academy of Sciences (India)

    In the case of carts with large wheels, the effect of variation of u on the neck oad is not significant on level terrain or sloping ground. For example, for a cart with wheels of diameter 183 cm (72 in.) on level ground, W/W, is only 0 006 and 0-014 at p of 0-2 and 0-5 respectively. However, the variation of the neck load with p is.

  16. Le commentaire de cartes et la «nouvelle géographie»

    Directory of Open Access Journals (Sweden)

    Alain REYNAUD

    1987-06-01

    Full Text Available Les cartes topographiques intéressent le public et attirent l'attention des penseurs, car elles constituent un support aussi bien pour le raisonnement et le rêve que pour l'action. Au même moment, le commentaire de cartes est remis en question parmi les géographes; mais il peut garder sa place à la condition d'affûter ses outils conceptuels et de diversifier ses thèmes.

  17. XUNET experimental high-speed network testbed CRADA 1136, DOE TTI No. 92-MULT-020-B2

    Energy Technology Data Exchange (ETDEWEB)

    Palmer, R.E.

    1996-04-01

    XUNET is a research program with AT&T and other partners to study high-speed wide area communication between local area networks over a backbone using Asynchronous Transfer Mode (ATM) switches. Important goals of the project are to develop software techniques for network control and management, and applications for high-speed networks. The project entails building a testbed between member sites to explore performance issues for mixed network traffic such as congestion control, multimedia communications protocols, segmentation and reassembly of ATM cells, and overall data throughput rates.

  18. CAR-T Cells: A Systematic Review and Mixed Methods Analysis of the Clinical Trial Landscape.

    Science.gov (United States)

    Pettitt, David; Arshad, Zeeshaan; Smith, James; Stanic, Tijana; Holländer, Georg; Brindley, David

    2018-02-07

    CAR-T cells are a promising new therapy that offer significant advantages compared with conventional immunotherapies. This systematic review and clinical trial landscape identifies and critiques published CAR-T cell clinical trials and examines the critical factors required to enable CAR-T cells to become a standard therapy. A review of the literature was conducted to identify suitable studies from the MEDLINE and Ovid bibliographic databases. The literature and database searches identified 20 studies for inclusion. The average number of participants per clinical trial examined was 11 patients. All studies included in this systematic review investigated CAR-T cells and were prospective, uncontrolled clinical studies. Leukemia is the most common cancer subtype and accounts for 57.4% (n = 120) of disease indications. The majority of studies used an autologous cell source (85%, n = 17) rather than an allogeneic cell source. Translational challenges encompass technical considerations relating to CAR-T cell development, manufacturing practicability, clinical trial approaches, CAR-T cell quality and persistence, and patient management. Copyright © 2017 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

  19. Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population

    Directory of Open Access Journals (Sweden)

    Hercberg Serge

    2005-04-01

    Full Text Available Abstract Background Cocaine and amphetamine regulated transcript (CART is an anorectic neuropeptide located principally in hypothalamus. CART has been shown to be involved in control of feeding behavior, but a direct relationship with obesity has not been established. The aim of this study was to evaluate the effect of polymorphisms within the CART gene with regards to a possible association with obesity in a Caucasian population. Results Screening of the entire gene as well as a 3.7 kb region of 5' upstream sequence revealed 31 SNPs and 3 rare variants ; 14 of which were subsequently genotyped in 292 French morbidly obese subjects and 368 controls. Haplotype analysis suggested an association with obesity which was found to be mainly due to SNP-3608T>C (rs7379701 (p = 0.009. Genotyping additional cases and controls also of European Caucasian origin supported further this possible association between the CART SNP -3608T>C T allele and obesity (global p-value = 0.0005. Functional studies also suggested that the SNP -3608T>C could modulate nuclear protein binding. Conclusion CART SNP -3608T>C may possibly contribute to the genetic risk for obesity in the Caucasian population. However confirmation of the importance of the role of the CART gene in energy homeostasis and obesity will require investigation and replication in further populations.

  20. Robust Control Algorithm for a Two Cart System and an Inverted Pendulum

    Science.gov (United States)

    Wilson, Chris L.; Capo-Lugo, Pedro

    2011-01-01

    The Rectilinear Control System can be used to simulate a launch vehicle during liftoff. Several control schemes have been developed that can control different dynamic models of the rectilinear plant. A robust control algorithm was developed that can control a pendulum to maintain an inverted position. A fluid slosh tank will be attached to the pendulum in order to test robustness in the presence of unknown slosh characteristics. The rectilinear plant consists of a DC motor and three carts mounted in series. Each cart s weight can be adjusted with brass masses and the carts can be coupled with springs. The pendulum is mounted on the first cart and an adjustable air damper can be attached to the third cart if desired. Each cart and the pendulum have a quadrature encoder to determine position. Full state feedback was implemented in order to develop the control algorithm along with a state estimator to determine the velocity states of the system. A MATLAB program was used to convert the state space matrices from continuous time to discrete time. This program also used a desired phase margin and damping ratio to determine the feedback gain matrix that would be used in the LabVIEW program. This experiment will allow engineers to gain a better understanding of liquid propellant slosh dynamics, therefore enabling them to develop more robust control algorithms for launch vehicle systems

  1. Histamine Recycling Is Mediated by CarT, a Carcinine Transporter in Drosophila Photoreceptors

    Science.gov (United States)

    Xu, Ying; An, Futing; Borycz, Jolanta A.; Borycz, Janusz; Meinertzhagen, Ian A.; Wang, Tao

    2015-01-01

    Histamine is an important chemical messenger that regulates multiple physiological processes in both vertebrate and invertebrate animals. Even so, how glial cells and neurons recycle histamine remains to be elucidated. Drosophila photoreceptor neurons use histamine as a neurotransmitter, and the released histamine is recycled through neighboring glia, where it is conjugated to β-alanine to form carcinine. However, how carcinine is then returned to the photoreceptor remains unclear. In an mRNA-seq screen for photoreceptor cell-enriched transporters, we identified CG9317, an SLC22 transporter family protein, and named it CarT (Carcinine Transporter). S2 cells that express CarT are able to take up carcinine in vitro. In the compound eye, CarT is exclusively localized to photoreceptor terminals. Null mutations of cart alter the content of histamine and its metabolites. Moreover, null cart mutants are defective in photoreceptor synaptic transmission and lack phototaxis. These findings reveal that CarT is required for histamine recycling at histaminergic photoreceptors and provide evidence for a CarT-dependent neurotransmitter trafficking pathway between glial cells and photoreceptor terminals. PMID:26713872

  2. Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.

    Science.gov (United States)

    Shcherbina, L; Edlund, A; Esguerra, J L S; Abels, M; Zhou, Y; Ottosson-Laakso, E; Wollheim, C B; Hansson, O; Eliasson, L; Wierup, N

    2017-05-15

    Impaired beta-cell function is key to the development of type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties. Here we studied the role of endogenous CART in beta-cell function. CART silencing in INS-1 (832/13) beta-cells reduced insulin secretion and production, ATP levels and beta-cell exocytosis. This was substantiated by reduced expression of several exocytosis genes, as well as reduced expression of genes important for insulin secretion and processing. In addition, CART silencing reduced the expression of a network of transcription factors essential for beta-cell function. Moreover, in RNAseq data from human islet donors, CARTPT expression levels correlated with insulin, exocytosis genes and key beta-cell transcription factors. Thus, endogenous beta-cell CART regulates insulin expression and secretion in INS-1 (832/13) cells, via actions on the exocytotic machinery and a network of beta-cell transcription factors. We conclude that CART is important for maintaining the beta-cell phenotype. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Analysis, Modeling, and Simulation (AMS) Testbed Development and Evaluation to Support Dynamic Mobility Applications (DMA) and Active Transportation and Demand Management (ATDM) Programs - San Mateo Testbed Analysis Plan [supporting datasets - San Mateo Testbed

    Science.gov (United States)

    2017-06-26

    This zip file contains files of data to support FHWA-JPO-16-370, Analysis, Modeling, and Simulation (AMS) Testbed Development and Evaluation to Support Dynamic Mobility Applications (DMA) and Active Transportation and Demand Management (ATDM) Program...

  4. Demographic and financial characteristics of school districts with low and high à la Carte sales in rural Kansas Public Schools.

    Science.gov (United States)

    Nollen, Nicole L; Kimminau, Kim S; Nazir, Niaman

    2011-06-01

    Reducing à la carte items in schools-foods and beverages sold outside the reimbursable meals program-can have important implications for childhood obesity. However, schools are reluctant to reduce à la carte offerings because of the impact these changes could have on revenue. Some foodservice programs operate with limited à la carte sales, but little is known about these programs. This secondary data analysis compared rural and urban/suburban school districts with low and high à la carte sales. Foodservice financial records (2007-2008) were obtained from the Kansas State Department of Education for all public K-12 school districts (n=302). χ² and t tests were used to examine the independent association of variables to à la carte sales. A multivariate model was then constructed of the factors most strongly associated with low à la carte sales. In rural districts with low à la carte sales, lunch prices and participation were higher, lunch costs and à la carte quality were lower, and fewer free/reduced price lunches were served compared to rural districts with high à la carte sales. Lunch price (odds ratio=1.2; 95% confidence interval, 1.1 to 1.4) and free/reduced price lunch participation (odds ratio=3.0; 95% confidence interval, 1.0 to 9.8) remained in the multivariate model predicting low à la carte sales. No differences were found between urban/suburban districts with low and high à la carte sales. Findings highlight important factors to maintaining low à la carte sales. Schools should consider raising lunch prices and increasing meal participation rates as two potential strategies for reducing the sale of à la carte items without compromising foodservice revenue. Copyright © 2011 American Dietetic Association. Published by Elsevier Inc. All rights reserved.

  5. Space construction: an experimental testbed to develop enabling technologies

    Science.gov (United States)

    Schubert, Heidi C.; How, Jonathan P.

    1997-12-01

    This paper discusses a new testbed developed at the Stanford Aerospace Robotics Laboratory (ARL) to address some of the key issues associated with semi-autonomous construction in a hazardous environment like space. The new testbed consists of a large two-link manipulator carrying two smaller two-link arms. This macro/mini combination was developed to be representative of actual space manipulators, such as the SSRMS/SPDM planned for the Space Station. This new testbed will allow us to investigate several key issues associated with space construction, including teleoperation versus supervised autonomy, dexterous control of a robot with flexibility, and construction with multiple robots. A supervised autonomy approach has several advantages over the traditional teleoperation mode, including operation with time delay, smart control of a redundant manipulator, and improved contact control. To mimic the dynamics found in space manipulators, the main arm was designed to include joint flexibility. The arm operates in 2-D, with the end-point floating on air-bearing. This setup allows cooperation with existing free-flying robots in the ARL. This paper reports the first experiments with the arm which explore the advantages of moving from teleoperation or human-in-the-loop control to the human supervisory or task-level control. A simple task, such as capturing a satellite-like object floating on the table, is attempted first with the human directly driving the end-point and second with the human directing the robot at a task-level. Initial experimental results of these two control approaches are presented and compared.

  6. ASE-BAN, a Wireless Body Area Network Testbed

    DEFF Research Database (Denmark)

    Madsen, Jens Kargaard; Karstoft, Henrik; Toftegaard, Thomas Skjødeberg

    2010-01-01

    /actuators attached to the body and a host server application. The gateway uses the BlackFin BF533 processor from Analog Devices, and uses Bluetooth for wireless communication. Two types of sensors are attached to the network: an electro-cardio-gram sensor and an oximeter sensor. The testbed has been successfully......Miniature Body Area Networks used in health care support greater mobility to patients and reduces actual hospitalization. This paper presents the preliminary implementation of a wireless body area network gateway. It is designed to implement the gateway functionality between sensors...... tested for electrocardio- gram data collection, and using wireless communication in a battery powered configuration....

  7. EMERGE - ESnet/MREN Regional Science Grid Experimental NGI Testbed

    Energy Technology Data Exchange (ETDEWEB)

    Mambretti, Joe; DeFanti, Tom; Brown, Maxine

    2001-07-31

    This document is the final report on the EMERGE Science Grid testbed research project from the perspective of the International Center for Advanced Internet Research (iCAIR) at Northwestern University, which was a subcontractor to this UIC project. This report is a compilation of information gathered from a variety of materials related to this project produced by multiple EMERGE participants, especially those at Electronic Visualization Lab (EVL) at the University of Illinois at Chicago (UIC), Argonne National Lab and iCAIR. The EMERGE Science Grid project was managed by Tom DeFanti, PI from EVL at UIC.

  8. The Living With a Star Space Environment Testbed Experiments

    Science.gov (United States)

    Xapsos, Michael A.

    2014-01-01

    The focus of the Living With a Star (LWS) Space Environment Testbed (SET) program is to improve the performance of hardware in the space radiation environment. The program has developed a payload for the Air Force Research Laboratory (AFRL) Demonstration and Science Experiments (DSX) spacecraft that is scheduled for launch in August 2015 on the SpaceX Falcon Heavy rocket. The primary structure of DSX is an Evolved Expendable Launch Vehicle (EELV) Secondary Payload Adapter (ESPA) ring. DSX will be in a Medium Earth Orbit (MEO). This oral presentation will describe the SET payload.

  9. The Living With a Star Program Space Environment Testbed

    Science.gov (United States)

    Barth, Janet; Day, John H. (Technical Monitor)

    2001-01-01

    This viewgraph presentation describes the objective, approach, and scope of the Living With a Star (LWS) program at the Marshall Space Flight Center. Scientists involved in the project seek to refine the understanding of space weather and the role of solar variability in terrestrial climate change. Research and the development of improved analytic methods have led to increased predictive capabilities and the improvement of environment specification models. Specifically, the Space Environment Testbed (SET) project of LWS is responsible for the implementation of improved engineering approaches to observing solar effects on climate change. This responsibility includes technology development, ground test protocol development, and the development of a technology application model/engineering tool.

  10. Software Testbed for Developing and Evaluating Integrated Autonomous Subsystems

    Science.gov (United States)

    Ong, James; Remolina, Emilio; Prompt, Axel; Robinson, Peter; Sweet, Adam; Nishikawa, David

    2015-01-01

    To implement fault tolerant autonomy in future space systems, it will be necessary to integrate planning, adaptive control, and state estimation subsystems. However, integrating these subsystems is difficult, time-consuming, and error-prone. This paper describes Intelliface/ADAPT, a software testbed that helps researchers develop and test alternative strategies for integrating planning, execution, and diagnosis subsystems more quickly and easily. The testbed's architecture, graphical data displays, and implementations of the integrated subsystems support easy plug and play of alternate components to support research and development in fault-tolerant control of autonomous vehicles and operations support systems. Intelliface/ADAPT controls NASA's Advanced Diagnostics and Prognostics Testbed (ADAPT), which comprises batteries, electrical loads (fans, pumps, and lights), relays, circuit breakers, invertors, and sensors. During plan execution, an experimentor can inject faults into the ADAPT testbed by tripping circuit breakers, changing fan speed settings, and closing valves to restrict fluid flow. The diagnostic subsystem, based on NASA's Hybrid Diagnosis Engine (HyDE), detects and isolates these faults to determine the new state of the plant, ADAPT. Intelliface/ADAPT then updates its model of the ADAPT system's resources and determines whether the current plan can be executed using the reduced resources. If not, the planning subsystem generates a new plan that reschedules tasks, reconfigures ADAPT, and reassigns the use of ADAPT resources as needed to work around the fault. The resource model, planning domain model, and planning goals are expressed using NASA's Action Notation Modeling Language (ANML). Parts of the ANML model are generated automatically, and other parts are constructed by hand using the Planning Model Integrated Development Environment, a visual Eclipse-based IDE that accelerates ANML model development. Because native ANML planners are currently

  11. SCaN Testbed Software Development and Lessons Learned

    Science.gov (United States)

    Kacpura, Thomas J.; Varga, Denise M.

    2012-01-01

    National Aeronautics and Space Administration (NASA) has developed an on-orbit, adaptable, Software Defined Radio (SDR)Space Telecommunications Radio System (STRS)-based testbed facility to conduct a suite of experiments to advance technologies, reduce risk, and enable future mission capabilities on the International Space Station (ISS). The SCAN Testbed Project will provide NASA, industry, other Government agencies, and academic partners the opportunity to develop and field communications, navigation, and networking technologies in the laboratory and space environment based on reconfigurable, SDR platforms and the STRS Architecture.The SDRs are a new technology for NASA, and the support infrastructure they require is different from legacy, fixed function radios. SDRs offer the ability to reconfigure on-orbit communications by changing software for new waveforms and operating systems to enable new capabilities or fix any anomalies, which was not a previous option. They are not stand alone devices, but required a new approach to effectively control them and flow data. This requires extensive software to be developed to utilize the full potential of these reconfigurable platforms. The paper focuses on development, integration and testing as related to the avionics processor system, and the software required to command, control, monitor, and interact with the SDRs, as well as the other communication payload elements. An extensive effort was required to develop the flight software and meet the NASA requirements for software quality and safety. The flight avionics must be radiation tolerant, and these processors have limited capability in comparison to terrestrial counterparts. A big challenge was that there are three SDRs onboard, and interfacing with multiple SDRs simultaneously complicatesd the effort. The effort also includes ground software, which is a key element for both the command of the payload, and displaying data created by the payload. The verification of

  12. CAR-T cells and allogeneic hematopoietic stem cell transplantation for relapsed/refractory B-cell acute lymphoblastic leukemia.

    Science.gov (United States)

    Liu, Jun; Zhang, Xi; Zhong, Jiang F; Zhang, Cheng

    2017-10-01

    Relapsed/refractory acute lymphoblastic leukemia (ALL) has a low remission rate after chemotherapy, a high relapse rate and poor long-term survival even when allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed. Chimeric antigen receptors redirected T cells (CAR-T cells) can enhance disease remission with a favorable outcome for relapsed/refractory ALL, though some cases quickly relapsed after CAR-T cell treatment. Thus, treatment with CAR-T cells followed by allo-HSCT may be the best way to treat relapsed/refractory ALL. In this review, we first discuss the different types of CAR-T cells. We then discuss the treatment of relapsed/refractory ALL using only CAR-T cells. Finally, we discuss the use of CAR-T cells, followed by allo-HSCT, for the treatment of relapsed/refractory ALL.

  13. 9-1-1 responses for shopping cart and stroller injuries.

    Science.gov (United States)

    Vilke, Gary M; Stepanski, Barbara M; Ray, Leslie Upledger; Lutz, Margaret W; Murrin, Patricia A; Chan, Theodore C

    2004-10-01

    On average, 24,000 children a year are treated in the emergency departments (EDs) for shopping cart injuries, with over 650 children a year requiring hospital admission. The authors sought to evaluate the incidence and outcomes of children in the community evaluated by paramedics because they were injured in shopping cart or stroller-related incidences. Retrospective design in which prehospital patients records were searched for all patients under 14 years old who were injured in an incident involving a shopping cart or stroller and were responded to by paramedics. Records were reviewed for demographics, injury type, and disposition. During the 3 1/2 year study period, a total of 241 cases were identified with 120 being shopping cart-related and 121 stroller-related. The most frequent ages for stroller injuries were 0 to 6 months and for shopping cart injuries was one year of age. Falls were the most common mechanism of injury, 70.3% for shopping carts and 47.5% for strollers, with head injuries accounting for 53% and 59% of the primary injuries in each group. An additional 12% and 18% suffered primary facial injuries. 77% of patients were transported by paramedics to an ED for evaluation, with 19% of parents signing out against medical advice. 8.2% were admitted to the hospital and there were no deaths. Shopping cart and stroller-related injuries are a common mechanism of injury for pediatric patients responded to by paramedics. This is an area which continued parental education is needed.

  14. Schoolchildren's consumption of competitive foods and beverages, excluding à la carte.

    Science.gov (United States)

    Kakarala, Madhuri; Keast, Debra R; Hoerr, Sharon

    2010-09-01

    Competitive foods/beverages are those in school vending machines, school stores, snack bars, special sales, and items sold à la carte in the school cafeteria that compete with United States Department of Agriculture (USDA) meal program offerings. Grouping à la carte items with less nutritious items allowed in less regulated venues may obfuscate analysis of the school competitive food environment. Excluding à la carte items from competitive foods, the objectives were to: (1) assess competitive food use by gender, ethnicity, eligibility for free or reduced-price meals, and participation in school meals programs, (2) determine differences between grade levels in energy intakes obtained from food sources, (3) determine the nutrient intake derived from competitive foods for students who consumed them, and (4) determine energy-adjusted differences in 24-hour nutrient intakes of protein, calcium, iron, and other selected nutrients between competitive food consumer and nonconsumers. Competitive foods/beverages use, excluding à la carte items, was examined using the third School Nutrition Dietary Assessment Study (SNDA III), a nationally representative sample of 2309 schoolchildren in grades 1 to 12. Mean nutrient intakes were adjusted for energy intake and other covariates, and differences between consumers and nonconsumers of competitive items were determined using analysis of variance and sudaan. Excluding à la carte items, 22% of schoolchildren consumed competitive items in a representative school day and use was highest in high school. Consumers of competitive items other than à la carte had significantly higher mean energy, sugar intakes, and lower sodium, dietary fiber, B vitamins, and iron intakes than nonconsumers. Use of competitive foods/beverages, excluding à la carte, was detrimental to children's diet quality.

  15. Investigation on the Expansion of Urban Construction Land Use Based on the CART-CA Model

    Directory of Open Access Journals (Sweden)

    Yongxiang Yao

    2017-05-01

    Full Text Available Change in urban construction land use is an important factor when studying urban expansion. Many scholars have combined cellular automata (CA with data mining algorithms to perform relevant simulation studies. However, the parameters for rule extraction are difficult to determine and the rules are simplex, and together, these factors tend to introduce excessive fitting problems and low modeling accuracy. In this paper, we propose a method to extract the transformation rules for a CA model based on the Classification and Regression Tree (CART. In this method, CART is used to extract the transformation rules for the CA. This method first adopts the CART decision tree using the bootstrap algorithm to mine the rules from the urban land use while considering the factors that impact the geographic spatial variables in the CART regression procedure. The weights of individual impact factors are calculated to generate a logistic regression function that reflects the change in urban construction land use. Finally, a CA model is constructed to simulate and predict urban construction land expansion. The urban area of Xinyang City in China is used as an example for this experimental research. After removing the spatial invariant region, the overall simulation accuracy is 81.38% and the kappa coefficient is 0.73. The results indicate that by using the CART decision tree to train the impact factor weights and extract the rules, it can effectively increase the simulation accuracy of the CA model. From convenience and accuracy perspectives for rule extraction, the structure of the CART decision tree is clear, and it is very suitable for obtaining the cellular rules. The CART-CA model has a relatively high simulation accuracy in modeling urban construction land use expansion, it provides reliable results, and is suitable for use as a scientific reference for urban construction land use expansion.

  16. Context-aware local Intrusion Detection in SCADA systems : a testbed and two showcases

    NARCIS (Netherlands)

    Chromik, Justyna Joanna; Haverkort, Boudewijn R.H.M.; Remke, Anne Katharina Ingrid; Pilch, Carina; Brackmann, Pascal; Duhme, Christof; Everinghoff, Franziska; Giberlein, Artur; Teodorowicz, Thomas; Wieland, Julian

    2017-01-01

    This paper illustrates the use of a testbed that we have developed for context-aware local intrusion detection. This testbed is based on the co-simulation framework Mosaik and allows for the validation of local intrusion detection mechanisms at field stations in power distribution networks. For two

  17. Development of a smart-antenna test-bed, demonstrating software defined digital beamforming

    NARCIS (Netherlands)

    Kluwer, T.; Slump, Cornelis H.; Schiphorst, Roelof; Hoeksema, F.W.

    2001-01-01

    This paper describes a smart-antenna test-bed consisting of ‘common of the shelf’ (COTS) hardware and software defined radio components. The use of software radio components enables a flexible platform to implement and test mobile communication systems as a real-world system. The test-bed is

  18. Off-road perception testbed vehicle design and evaluation

    Science.gov (United States)

    Spofford, John R.; Herron, Jennifer B.; Anhalt, David J.; Morgenthaler, Matthew K.; DeHerrera, Clinton

    2003-09-01

    Off-road robotics efforts such as DARPA"s PerceptOR program have motivated the development of testbed vehicles capable of sustained operation in a variety of terrain and environments. This paper describes the retrofitting of a minimally-modified ATV chassis into such a testbed which has been used by multiple programs for autonomous mobility development and sensor characterization. Modular mechanical interfaces for sensors and equipment enclosures enabled integration of multiple payload configurations. The electric power subsystem was capable of short-term operation on batteries with refueled generation for continuous operation. Processing subsystems were mounted in sealed, shock-dampened enclosures with heat exchangers for internal cooling to protect against external dust and moisture. The computational architecture was divided into a real-time vehicle control layer and an expandable high level processing and perception layer. The navigation subsystem integrated real time kinematic GPS with a three-axis IMU for accurate vehicle localization and sensor registration. The vehicle software system was based on the MarsScape architecture developed under DARPA"s MARS program. Vehicle mobility software capabilities included route planning, waypoint navigation, teleoperation, and obstacle detection and avoidance. The paper describes the vehicle design in detail and summarizes its performance during field testing.

  19. A Battery Certification Testbed for Small Satellite Missions

    Science.gov (United States)

    Cameron, Zachary; Kulkarni, Chetan S.; Luna, Ali Guarneros; Goebel, Kai; Poll, Scott

    2015-01-01

    A battery pack consisting of standard cylindrical 18650 lithium-ion cells has been chosen for small satellite missions based on previous flight heritage and compliance with NASA battery safety requirements. However, for batteries that transit through the International Space Station (ISS), additional certification tests are required for individual cells as well as the battery packs. In this manuscript, we discuss the development of generalized testbeds for testing and certifying different types of batteries critical to small satellite missions. Test procedures developed and executed for this certification effort include: a detailed physical inspection before and after experiments; electrical cycling characterization at the cell and pack levels; battery-pack overcharge, over-discharge, external short testing; battery-pack vacuum leak and vibration testing. The overall goals of these certification procedures are to conform to requirements set forth by the agency and identify unique safety hazards. The testbeds, procedures, and experimental results are discussed for batteries chosen for small satellite missions to be launched from the ISS.

  20. Benchmarking Diagnostic Algorithms on an Electrical Power System Testbed

    Science.gov (United States)

    Kurtoglu, Tolga; Narasimhan, Sriram; Poll, Scott; Garcia, David; Wright, Stephanie

    2009-01-01

    Diagnostic algorithms (DAs) are key to enabling automated health management. These algorithms are designed to detect and isolate anomalies of either a component or the whole system based on observations received from sensors. In recent years a wide range of algorithms, both model-based and data-driven, have been developed to increase autonomy and improve system reliability and affordability. However, the lack of support to perform systematic benchmarking of these algorithms continues to create barriers for effective development and deployment of diagnostic technologies. In this paper, we present our efforts to benchmark a set of DAs on a common platform using a framework that was developed to evaluate and compare various performance metrics for diagnostic technologies. The diagnosed system is an electrical power system, namely the Advanced Diagnostics and Prognostics Testbed (ADAPT) developed and located at the NASA Ames Research Center. The paper presents the fundamentals of the benchmarking framework, the ADAPT system, description of faults and data sets, the metrics used for evaluation, and an in-depth analysis of benchmarking results obtained from testing ten diagnostic algorithms on the ADAPT electrical power system testbed.

  1. Boosting Neural Network dan Boosting Cart Pada Klasifikasi Diabetes Militus Tipe II

    Directory of Open Access Journals (Sweden)

    Jerhi Wahyu Fernanda

    2012-12-01

    Full Text Available Diabetes Militus Tipe II merupakan salah satu penyakit yang paling banyak diderita masyarakat Indonesia. Untuk mengantisipasi terkena penyakit DM tipe II, diperlukan suatu tindakan untuk mengurangi resiko terkena penyakit ini dengan mengetahui faktor-faktor resiko yang menyebabkan DM tipe II. Beberapa faktor-faktor resiko yang dapat menyebabkan penyakit ini adalah Riwayat Keturunan, Umur, Jenis Kelamin, Obesitas, Pola Makan, Aktifitas Olahraga. Penelitian tentang klasifikasi DM tipe II telah banyak dilakukan dengan menggunakan metode-metode klasifikasi. Seperti Artificial Neural Network(ANN, CART, dan lain-lain. Tingkat akurasi dari suatu metode klasifikasi seperti ANN, CART dapat ditingkatkan untuk memberikan hasil klasifikasi yang lebih baik dengan menggunakan metodeboosting. Boostingadalah metodeensemble yang digunakan untuk meningkatkan akurasi dari suatu metode klasifikasi. Salah satu variasi boosting adalah adaboost. Beberapa penelitian juga telah menunjukkan bahwa adaboost mampu meningkatkan akurasi dari suatu metode klasifikasi. Penelitian ini dilakukan untuk mengkaji implementasi boosting pada metode Feedforwarf Neural Network (FFNN dan CART. Hasil klasifikasi memperlihatkan bahwa tingkat akurasi dari FFNN dan CART setelah dilakukan boosting mengalami kenaikan dibandingkan sebelum dilakukan proses boosting. Berdasarkan nilai AUC didapatkan metode boosting CART pada iterasi 50, 100, 200, dan 500 memiliki tingkat akurasi yang paling tinggi dengan tingkat akurasi sebesar 98.75% dibandingakan dengan FFNN dan boosting FFNN.

  2. Boosting Neural Network dan Boosting Cart Pada Klasifikasi Diabetes Militus Tipe II

    Directory of Open Access Journals (Sweden)

    Jerhi Wahyu Fernanda

    2013-10-01

    Full Text Available Diabetes Militus Tipe II merupakan salah satu penyakit yang paling banyak diderita masyarakat Indonesia. Untuk mengantisipasi terkena penyakit DM tipe II, diperlukan suatu tindakan untuk mengurangi resiko terkena penyakit ini dengan mengetahui faktor-faktor resiko yang menyebabkan DM tipe II. Beberapa faktor-faktor resiko yang dapat menyebabkan penyakit ini adalah Riwayat Keturunan, Umur, Jenis Kelamin, Obesitas, Pola Makan, Aktifitas Olahraga. Penelitian tentang klasifikasi DM tipe II telah banyak dilakukan dengan menggunakan metode-metode klasifikasi. Seperti Artificial Neural Network(ANN, CART, dan lain-lain. Tingkat akurasi dari suatu metode klasifikasi seperti ANN, CART dapat ditingkatkan untuk memberikan hasil klasifikasi yang lebih baik dengan menggunakan metodeboosting. Boostingadalah metodeensemble yang digunakan untuk meningkatkan akurasi dari suatu metode klasifikasi. Salah satu variasi boosting adalah adaboost. Beberapa penelitian juga telah menunjukkan bahwa adaboost mampu meningkatkan akurasi dari suatu metode klasifikasi. Penelitian ini dilakukan untuk mengkaji implementasi boosting pada metode Feedforwarf Neural Network (FFNN dan CART. Hasil klasifikasi memperlihatkan bahwa tingkat akurasi dari FFNN dan CART setelah dilakukan boosting mengalami kenaikan dibandingkan sebelum dilakukan proses boosting. Berdasarkan nilai AUC didapatkan metode boosting CART pada iterasi 50, 100, 200, dan 500 memiliki tingkat akurasi yang paling tinggi dengan tingkat akurasi sebesar 98.75% dibandingakan dengan FFNN dan boosting FFNN.

  3. Preliminary Core Analysis of High Temperature Engineering Test Reactor Using DeCART Code

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Chang Joon; Lee, Hyun Chul; Noh, Jae Man [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The 2-dimensional core analysis for the High Temperature Engineering Test Reactor (HTTR) has been performed. The HTTR is a graphite-moderated and helium gas cooled reactor with an outlet temperature of 950 .deg. C and thermal output of 30 MW. In this study, the DECART code is used with a 190-group KARMA library. The calculation results are compared with those of the McCARD with the ENDF-B/VII.0 library. From the analysis results, it is known that the DeCART code generally overestimates k{sub inf} with a moderator temperature variation. In addition, it can be seen that the DeCART code predicts less negative MTC than the McCARD code. However, the DeCART code gives a slightly more negative FTC value. From the depletion results, the error of the DeCART decreases over the burnup until 600 FPD. The DeCART code gives very similar trend within the error of 190 pcm, which is very small error when compared with other result.

  4. Otolaryngology Consult Carts: Maximizing Patient Care, Surgeon Efficiency, and Cost Containment.

    Science.gov (United States)

    Royer, Mark C; Royer, Allison K

    2015-11-01

    The objective of this study was to develop an otolaryngology consult cart system to ensure prompt delivery to the bedside of all the unique equipment and medications required for emergent and urgent otolaryngology consults. An otolaryngology practice responsible for emergency room and hospital consult coverage sought to create a cart containing all equipment, medications, and supplies for otolaryngology consults. Meetings with hospital administration and emergency room, nursing, pharmacy, central processing, and operating room staff were held to develop a system for the emergent delivery of the cart to the needed location, sterilization and restocking of equipment between uses, and appropriate billing of supplies. Two months were required from conception to implementation. All equipment was purchased new, including flexible scopes and headlights. The cart is sterilized, restocked, and maintained by central processing after each use. The equipment is available to handle all airway emergencies as well as all common otolaryngology consults and is delivered bedside in less than 5 minutes. The development of a self-contained otolaryngology consult cart requires coordination with a wide variety of hospital departments. This system, while requiring initial monetary and time investment, has resulted in improved patient care, cost containment, and surgeon convenience. © The Author(s) 2015.

  5. Dynamic Gesture Recognition based on LeapMotion and HMM-CART Model

    Science.gov (United States)

    Zhang, Qixiang; Deng, Fang

    2017-10-01

    This paper focuses on improving the recognition accuracy of dynamic gesture learning, and proposes dynamic gesture track recognition strategy based on HMM-CART model structure. It integrates the modeling ability of the HMM (Hidden-Markov-Model) for time series data and the interpretability of CART (Classification-And-Regression-Tree) for its ability of fast classification and regression, and use it for dynamic gesture recognition. Time series data of movement gestures collected by LeapMotion sensor will be first divided into four channels: finger shape, palm normal vector, palm ball radius and palm displacement vector, and then HMM in HMM Layer will be built for each channel, finally the likelihood probability of model calculated for each sub-sequence of observation should be classified as the input of the CART model in CART Layer to identify the gesture. Experiments show that the accuracy of dynamic gesture recognition method using HMM-CART model is higher than that of traditional single channel HMM.

  6. CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth

    Directory of Open Access Journals (Sweden)

    Vita Golubovskaya

    2017-10-01

    Full Text Available CD47 is a glycoprotein of the immunoglobulin superfamily that is often overexpressed in different types of hematological and solid cancer tumors and plays important role in blocking phagocytosis, increased tumor survival, metastasis and angiogenesis. In the present report, we designed CAR (chimeric antigen receptor-T cells that bind CD47 antigen. We used ScFv (single chain variable fragment from mouse CD47 antibody to generate CD47-CAR-T cells for targeting different cancer cell lines. CD47-CAR-T cells effectively killed ovarian, pancreatic and other cancer cells and produced high level of cytokines that correlated with expression of CD47 antigen. In addition, CD47-CAR-T cells significantly blocked BxPC3 pancreatic xenograft tumor growth after intratumoral injection into NSG mice. Moreover, we humanized mouse CD47 ScFv and showed that it effectively bound CD47 antigen. The humanized CD47-CAR-T cells also specifically killed ovarian, pancreatic, and cervical cancer cell lines and produced IL-2 that correlated with expression of CD47. Thus, CD47-CAR-T cells can be used as a novel cellular therapeutic agent for treating different types of cancer.

  7. CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth.

    Science.gov (United States)

    Golubovskaya, Vita; Berahovich, Robert; Zhou, Hua; Xu, Shirley; Harto, Hizkia; Li, Le; Chao, Cheng-Chi; Mao, Mike Ming; Wu, Lijun

    2017-10-21

    CD47 is a glycoprotein of the immunoglobulin superfamily that is often overexpressed in different types of hematological and solid cancer tumors and plays important role in blocking phagocytosis, increased tumor survival, metastasis and angiogenesis. In the present report, we designed CAR (chimeric antigen receptor)-T cells that bind CD47 antigen. We used ScFv (single chain variable fragment) from mouse CD47 antibody to generate CD47-CAR-T cells for targeting different cancer cell lines. CD47-CAR-T cells effectively killed ovarian, pancreatic and other cancer cells and produced high level of cytokines that correlated with expression of CD47 antigen. In addition, CD47-CAR-T cells significantly blocked BxPC3 pancreatic xenograft tumor growth after intratumoral injection into NSG mice. Moreover, we humanized mouse CD47 ScFv and showed that it effectively bound CD47 antigen. The humanized CD47-CAR-T cells also specifically killed ovarian, pancreatic, and cervical cancer cell lines and produced IL-2 that correlated with expression of CD47. Thus, CD47-CAR-T cells can be used as a novel cellular therapeutic agent for treating different types of cancer.

  8. Cancer Immunotherapy Using CAR-T Cells: From the Research Bench to the Assembly Line.

    Science.gov (United States)

    Gomes-Silva, Diogo; Ramos, Carlos A

    2018-02-01

    The focus of cancer treatment has recently shifted toward targeted therapies, including immunotherapy, which allow better individualization of care and are hoped to increase the probability of success for patients. Specifically, T cells genetically modified to express chimeric antigen receptors (CARs; CAR-T cells) have generated exciting results. Recent clinical successes with this cutting-edge therapy have helped to push CAR-T cells toward approval for wider use. However, several limitations need to be addressed before the widespread use of CAR-T cells as a standard treatment. Here, a succinct background on adoptive T-cell therapy (ATCT)is given. A brief overview of the structure of CARs, how they are introduced into T cells, and how CAR-T cell expansion and selection is achieved in vitro is then presented. Some of the challenges in CAR design are discussed, as well as the difficulties that arise in large-scale CAR-T cell manufacture that will need to be addressed to achieve successful commercialization of this type of cell therapy. Finally, developments already on the horizon are discussed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. New Approaches in CAR-T Cell Immunotherapy for Breast Cancer.

    Science.gov (United States)

    Wang, Jinghua; Zhou, Penghui

    2017-01-01

    Despite significant advances in surgery, chemotherapy, radiotherapy, endocrine therapy, and molecular-targeted therapy, breast cancer remains the leading cause of death from malignant tumors among women. Immunotherapy has recently become a critical component of breast cancer treatment with encouraging activity and mild safety profiles. CAR-T therapy using genetically modifying T cells with chimeric antigen receptors (CAR) is the most commonly used approach to generate tumor-specific T cells. It has shown good curative effect for a variety of malignant diseases, especially for hematological malignancies. In this review, we briefly introduce the history and the present state of CAR research. Then we discuss the barriers of solid tumors for CARs application and possible strategies to improve therapeutic response with a focus on breast cancer. At last, we outlook the future directions of CAR-T therapy including managing toxicities and developing universal CAR-T cells.

  10. Neurotransmitter CART as a New Therapeutic Candidate for Parkinson’s Disease

    Directory of Open Access Journals (Sweden)

    Philippe Thuillier

    2013-01-01

    Full Text Available Parkinson’s disease (PD is one of the most common neurodegenerative diseases. To date, there is no effective treatment that halts its progression. Increasing evidence indicates that mitochondria play an important role in the development of PD. Hence mitochondria-targeted approaches or agents may have therapeutic promise for treatment of the disease. Neuropeptide CART (cocaine-amphetamine-regulated transcript, a hypothalamus and midbrain enriched neurotransmitter with an antioxidant property, can be found in mitochondria, which is the main source of reactive oxygen species. Systemic administration of CART has been found to ameliorate dopaminergic neuronal loss and improve motor functions in a mouse model of PD. In this article, we summarize recent progress in studies investigating the relationship between CART, dopamine, and the pathophysiology of PD, with a focus on mitochondria-related topics.

  11. Golf cart prototype development and navigation simulation using ROS and Gazebo

    Directory of Open Access Journals (Sweden)

    Shimchik Ilya

    2016-01-01

    Full Text Available This paper presents our approach to development of an autonomous golf cart, which will navigate in inaccessible by regular vehicles private areas. For this purpose, we have built a virtual golf course terrain and golf cart model in Gazebo, selected and modernized ROS-based packages in order to use them with Ackermann steering vehicle simulation. To verify our simulation and algorithms, we navigated the golf cart model from one golf hole to another within a virtual 3D golf course. For the real world algorithms’ verification, we developed a small-size vehicle prototype based on Traxxas radio-controlled car model, which is equipped with an on-board controller and sensors. The autonomous navigation of Traxxas-based vehicle prototype has been tested in indoor environment, where it utilized sensory data about environment and vehicle states, and performed localization, optimal trajectory computation and dynamic obstacles’ recognition with adjusting the route in real time.

  12. Design of the Dual Conjugate Adaptive Optics Test-bed

    Science.gov (United States)

    Sharf, Inna; Bell, K.; Crampton, D.; Fitzsimmons, J.; Herriot, Glen; Jolissaint, Laurent; Lee, B.; Richardson, H.; van der Kamp, D.; Veran, Jean-Pierre

    In this paper, we describe the Multi-Conjugate Adaptive Optics laboratory test-bed presently under construction at the University of Victoria, Canada. The test-bench will be used to support research in the performance of multi-conjugate adaptive optics, turbulence simulators, laser guide stars and miniaturizing adaptive optics. The main components of the test-bed include two micro-machined deformable mirrors, a tip-tilt mirror, four wavefront sensors, a source simulator, a dual-layer turbulence simulator, as well as computational and control hardware. The paper will describe in detail the opto-mechanical design of the adaptive optics module, the design of the hot-air turbulence generator and the configuration chosen for the source simulator. Below, we present a summary of these aspects of the bench. The optical and mechanical design of the test-bed has been largely driven by the particular choice of the deformable mirrors. These are continuous micro-machined mirrors manufactured by Boston Micromachines Corporation. They have a clear aperture of 3.3 mm and are deformed with 140 actuators arranged in a square grid. Although the mirrors have an open-loop bandwidth of 6.6 KHz, their shape can be updated at a sampling rate of 100 Hz. In our optical design, the mirrors are conjugated at 0km and 10 km in the atmosphere. A planar optical layout was achieved by using four off-axis paraboloids and several folding mirrors. These optics will be mounted on two solid blocks which can be aligned with respect to each other. The wavefront path design accommodates 3 monochromatic guide stars that can be placed at either 90 km or at infinity. The design relies on the natural separation of the beam into 3 parts because of differences in locations of the guide stars in the field of view. In total four wavefront sensors will be procured from Adaptive Optics Associates (AOA) or built in-house: three for the guide stars and the fourth to collect data from the science source output in

  13. Space Station technology testbed: 2010 deep space transport

    Science.gov (United States)

    Holt, Alan C.

    1993-12-01

    A space station in a crew-tended or permanently crewed configuration will provide major R&D opportunities for innovative, technology and materials development and advanced space systems testing. A space station should be designed with the basic infrastructure elements required to grow into a major systems technology testbed. This space-based technology testbed can and should be used to support the development of technologies required to expand our utilization of near-Earth space, the Moon and the Earth-to-Jupiter region of the Solar System. Space station support of advanced technology and materials development will result in new techniques for high priority scientific research and the knowledge and R&D base needed for the development of major, new commercial product thrusts. To illustrate the technology testbed potential of a space station and to point the way to a bold, innovative approach to advanced space systems' development, a hypothetical deep space transport development and test plan is described. Key deep space transport R&D activities are described would lead to the readiness certification of an advanced, reusable interplanetary transport capable of supporting eight crewmembers or more. With the support of a focused and highly motivated, multi-agency ground R&D program, a deep space transport of this type could be assembled and tested by 2010. Key R&D activities on a space station would include: (1) experimental research investigating the microgravity assisted, restructuring of micro-engineered, materials (to develop and verify the in-space and in-situ 'tuning' of materials for use in debris and radiation shielding and other protective systems), (2) exposure of microengineered materials to the space environment for passive and operational performance tests (to develop in-situ maintenance and repair techniques and to support the development, enhancement, and implementation of protective systems, data and bio-processing systems, and virtual reality and

  14. SPHERES: Design of a Formation Flying Testbed for ISS

    Science.gov (United States)

    Sell, S. W.; Chen, S. E.

    2002-01-01

    The SPHERES (Synchronized Position Hold Engage and Reorient Experimental Satellites) payload is an innovative formation-flying spacecraft testbed currently being developed for use internally aboard the International Space Station (ISS). The purpose of the testbed is to provide a cost-effective, long duration, replenishable, and easily reconfigurable platform with representative dynamics for the development and validation of metrology, formation flying, and autonomy algorithms. The testbed components consist of three 8-inch diameter free-flying "satellites," five ultrasound beacons, and an ISS laptop workstation. Each satellite is self-contained with on-board battery power, cold-gas propulsion (CO2), and processing systems. Satellites use two packs of eight standard AA batteries for approximately 90 minutes of lifetime while beacons last the duration of the mission powered by a single AA battery. The propulsion system uses pressurized carbon dioxide gas, stored in replaceable tanks, distributed through an adjustable regulator and associated tubing to twelve thrusters located on the faces of the satellites. A Texas Instruments C6701 DSP handles control algorithm data while an FPGA manages all sensor data, timing, and communication processes on the satellite. All three satellites communicate with each other and with the controlling laptop via a wireless RF link. Five ultrasound beacons, located around a predetermined work area, transmit ultrasound signals that are received by each satellite. The system effectively acts as a pseudo-GPS system, allowing the satellites to determine position and attitude and to navigate within the test arena. The payload hardware are predominantly Commercial Off The Shelf (COTS) products with the exception of custom electronics boards, selected propulsion system adaptors, and beacon and satellite structural elements. Operationally, SPHERES will run in short duration test sessions with approximately two weeks between each session. During

  15. Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts: Combination or Built-In CAR-T

    Directory of Open Access Journals (Sweden)

    Dok Hyun Yoon

    2018-01-01

    Full Text Available Chimeric antigen receptor (CAR T cell therapy represents the first U.S. Food and Drug Administration approved gene therapy and these engineered cells function with unprecedented efficacy in the treatment of refractory CD19 positive hematologic malignancies. CAR translation to solid tumors is also being actively investigated; however, efficacy to date has been variable due to tumor-evolved mechanisms that inhibit local immune cell activity. To bolster the potency of CAR-T cells, modulation of the immunosuppressive tumor microenvironment with immune-checkpoint blockade is a promising strategy. The impact of this approach on hematological malignancies is in its infancy, and in this review we discuss CAR-T cells and their synergy with immune-checkpoint blockade.

  16. Hybrid Lyot coronagraph for WFIRST: high-contrast broadband testbed demonstration

    Science.gov (United States)

    Seo, Byoung-Joon; Cady, Eric; Gordon, Brian; Kern, Brian; Lam, Raymond; Marx, David; Moody, Dwight; Muller, Richard; Patterson, Keith; Poberezhskiy, Ilya; Mejia Prada, Camilo; Sidick, Erkin; Shi, Fang; Trauger, John; Wilson, Daniel

    2017-09-01

    Hybrid Lyot Coronagraph (HLC) is one of the two operating modes of the Wide-Field InfraRed Survey Telescope (WFIRST) coronagraph instrument. Since being selected by National Aeronautics and Space Administration (NASA) in December 2013, the coronagraph technology is being matured to Technology Readiness Level (TRL) 6 by 2018. To demonstrate starlight suppression in presence of expecting on-orbit input wavefront disturbances, we have built a dynamic testbed in Jet Propulsion Laboratory (JPL) in 2016. This testbed, named as Occulting Mask Coronagraph (OMC) testbed, is designed analogous to the WFIRST flight instrument architecture: It has both HLC and Shape Pupil Coronagraph (SPC) architectures, and also has the Low Order Wavefront Sensing and Control (LOWFS/C) subsystem to sense and correct the dynamic wavefront disturbances. We present upto-date progress of HLC mode demonstration in the OMC testbed. SPC results will be reported separately. We inject the flight-like Line of Sight (LoS) and Wavefront Error (WFE) perturbation to the OMC testbed and demonstrate wavefront control using two deformable mirrors while the LOWFS/C is correcting those perturbation in our vacuum testbed. As a result, we obtain repeatable convergence below 5 × 10-9 mean contrast with 10% broadband light centered at 550 nm in the 360 degrees dark hole with working angle between 3 λ/D and 9 λ/D. We present the key hardware and software used in the testbed, the performance results and their comparison to model expectations.

  17. Early epoch stellar positions from the Bordeaux Carte du Ciel

    Science.gov (United States)

    Odenkirchen, Michael; Soubiran, Caroline; Le Campion, J. François

    Astrometric measurements made by the satellite Hipparcos have brought forth a homogeneous system of precise proper motions of about 105 stars, which is unprecedented in its combination of quality and quantity. Such proper motions are of great importance in various sorts of kinematic studies. However, the proper motion system needs to be disseminated and extended to stars of fainter magnitudes by means of earth-bound observations. Here, photographic records of star positions from the beginning of the 20th century present a valuable and indispensable source of information. A first important step was made with the construction of the ACT Catalogue (Urban et al. 1997), which incorporates the ancient plate measurements of the so-called Astrographic Catalogue (AC). A second series of plates, the so-called Carte du Ciel (CdC), taken as part of the same survey project as the AC, has not been used systematically for astrometry so far. The advantage of the CdC is that it reaches about 3 mag fainter than the AC. It provides however less redundancy from plate overlap. The Observatoire de Bordeaux has initiated a program for the digitisation and measurement of its collection of CdC plates which covers the zone of +11 to +17 declination and contains positions for about 8 × 105 stars at epochs mostly between 1910 and 1920. As a pilot study for this program, we are currently working on two regions near the galactic anticenter, one surrounding the open cluster NGC 2355, the other intersecting the galactic plane at l 195. These regions were selected for practical as well as for scientific reasons. The plates have been digitised on the MAMA machine at the Observatoire de Paris. Object detection was made using the software SExtractor (Bertin & Arnouts 1996). The plate limit proves to be at B = 15 and a completeness of 80 percent is reached up to 14th magnitude. The plates of the CdC provide three equal exposures with a small angular separation of 10 arc second. A loss of about 20

  18. X-ray Pulsar Navigation Algorithms and Testbed for SEXTANT

    Science.gov (United States)

    Winternitz, Luke M. B.; Hasouneh, Monther A.; Mitchell, Jason W.; Valdez, Jennifer E.; Price, Samuel R.; Semper, Sean R.; Yu, Wayne H.; Ray, Paul S.; Wood, Kent S.; Arzoumanian, Zaven; hide

    2015-01-01

    The Station Explorer for X-ray Timing and Navigation Technology (SEXTANT) is a NASA funded technologydemonstration. SEXTANT will, for the first time, demonstrate real-time, on-board X-ray Pulsar-based Navigation (XNAV), a significant milestone in the quest to establish a GPS-like navigation capability available throughout our Solar System and beyond. This paper describes the basic design of the SEXTANT system with a focus on core models and algorithms, and the design and continued development of the GSFC X-ray Navigation Laboratory Testbed (GXLT) with its dynamic pulsar emulation capability. We also present early results from GXLT modeling of the combined NICER X-ray timing instrument hardware and SEXTANT flight software algorithms.

  19. The Benchmark Extensible Tractable Testbed Engineering Resource (BETTER)

    Energy Technology Data Exchange (ETDEWEB)

    Siranosian, Antranik Antonio [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Schembri, Philip Edward [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Miller, Nathan Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-02

    The Benchmark Extensible Tractable Testbed Engineering Resource (BETTER) is proposed as a family of modular test bodies that are intended to support engineering capability development by helping to identify weaknesses and needs. Weapon systems, subassemblies, and components are often complex and difficult to test and analyze, resulting in low confidence and high uncertainties in experimental and simulated results. The complexities make it difficult to distinguish between inherent uncertainties and errors due to insufficient capabilities. BETTER test bodies will first use simplified geometries and materials such that testing, data collection, modeling and simulation can be accomplished with high confidence and low uncertainty. Modifications and combinations of simple and well-characterized BETTER test bodies can then be used to increase complexity in order to reproduce relevant mechanics and identify weaknesses. BETTER can provide both immediate and long-term improvements in testing and simulation capabilities. This document presents the motivation, concept, benefits and examples for BETTER.

  20. A Fully Reconfigurable Polarimetric Phased Array Antenna Testbed

    Directory of Open Access Journals (Sweden)

    Sudantha Perera

    2014-01-01

    Full Text Available The configurable phased array demonstrator (CPAD is a low-cost, reconfigurable, small-scale testbed for the dual-polarized array antenna and radar prototype. It is based on the concept that individual transmit and receive (TR modules and radiating elements can be configured in different ways to study the impact of various array manifolds on radiation pattern performance. For example, CPAD is configured as (a a 4 × 4 planar array, (b a planar array with mirror configuration, and (c a circular array to support the multifunctional phased array radar (MPAR system risk reduction studies. System descriptions are given in detail, and measurements are made and results are analyzed.

  1. Modular, Rapid Propellant Loading System/Cryogenic Testbed

    Science.gov (United States)

    Hatfield, Walter, Sr.; Jumper, Kevin

    2012-01-01

    The Cryogenic Test Laboratory (CTL) at Kennedy Space Center (KSC) has designed, fabricated, and installed a modular, rapid propellant-loading system to simulate rapid loading of a launch-vehicle composite or standard cryogenic tank. The system will also function as a cryogenic testbed for testing and validating cryogenic innovations and ground support equipment (GSE) components. The modular skid-mounted system is capable of flow rates of liquid nitrogen from 1 to 900 gpm (approx equals 3.8 to 3,400 L/min), of pressures from ambient to 225 psig (approx equals 1.5 MPa), and of temperatures to -320 F (approx equals -195 C). The system can be easily validated to flow liquid oxygen at a different location, and could be easily scaled to any particular vehicle interface requirements

  2. A multispectral testbed for cardiovascular sensing using imaging photoplethysmography

    Science.gov (United States)

    Blackford, Ethan B.; Estepp, Justin R.

    2017-02-01

    Imaging photoplethysmography uses image sensors to measure changes in light absorption resulting from skin microvascular blood volume pulsations throughout the cardiac cycle. Imaging photoplethysmography has been demonstrated as an effective, non-contact means of assessing pulse rate, pulse rate variability, and respiration rate. Other potential uses include measuring spatial blood perfusion, oxygenation, and flow dynamics. Herein we demonstrate the development of a multispectral testbed for imaging photoplethysmography consisting of 12 monochromatic, 120fps imagers with 50nm, bandpass filters distributed from 400-750nm and contained in a 3D-printed, 4x3 grid housing mounted on a tripod positioned orthogonal to the subject. A co-located dual-CCD RGB/near-infrared imager records conventional RGB and NIR images expanding the spectral window recorded. After image registration, a multispectral image cube of the 13, partially overlapping bands is created. A spectrometer records high (spectral) resolution data from the participant's right cheek using a collimating lens attached to the measurement fiber. In addition, a spatial array of 5 RGB imagers placed at 0°, +/-20° and +/-40° positions with respect to the subject is employed for motion and spatial robustness. All imagers are synchronized by a hardware trigger source synchronized with a reference, physiological measurement device recording the subject's electrocardiography, bilateral fingertip and/or ear lobe photoplethysmography, bilateral galvanic skin response, and respiration signals. The development of the testbed and pilot data is presented. A full-scale evaluation of the spectral components of the imaging photoplethysmographic signal, optimization of iPPG SNR, and spatial perfusion and blood flow dynamics is currently underway.

  3. Demo III: Department of Defense testbed for unmanned ground mobility

    Science.gov (United States)

    Shoemaker, Chuck M.; Bornstein, Jonathan A.; Myers, Scott D.; Brendle, Bruce E., Jr.

    1999-07-01

    Robotics has been identified by numerous recent Department of Defense (DOD) studies as a key enabling technology for future military operational concepts. The Demo III Program is a multiyear effort encompassing technology development and demonstration on testbed platforms, together with modeling simulation and experimentation directed toward optimization of operational concepts to employ this technology. Primary program focus is the advancement of capabilities for autonomous mobility through unstructured environments, concentrating on both perception and intelligent control technology. The scout mission will provide the military operational context for demonstration of this technology, although a significant emphasis is being placed upon both hardware and software modularity to permit rapid extension to other military missions. The Experimental Unmanned Vehicle (XUV) is a small (approximately 1150 kg, V-22 transportable) technology testbed vehicle designed for experimentation with multiple military operational concepts. Currently under development, the XUV is scheduled for roll-out in Summer 1999, with an initial troop experimentation to be conducted in September 1999. Though small, and relatively lightweight, modeling has shown the chassis capable of automotive mobility comparable to the current Army lightweight high-mobility, multipurpose, wheeled vehicle (HMMWV). The XUV design couples multisensor perception with intelligent control to permit autonomous cross-country navigation at speeds of up to 32 kph during daylight and 16 kph during hours of darkness. A small, lightweight, highly capable user interface will permit intuitive control of the XUV by troops from current-generation tactical vehicles. When it concludes in 2002, Demo III will provide the military with both the technology and the initial experience required to develop and field the first generation of semi-autonomous tactical ground vehicles for combat, combat support, and logistics applications.

  4. High Precision Testbed to Evaluate Ethernet Performance for In-Car Networks

    DEFF Research Database (Denmark)

    Revsbech, Kasper; Madsen, Tatiana Kozlova; Schiøler, Henrik

    2012-01-01

    Validating safety-critical real-time systems such as in-car networks often involves a model-based performance analysis of the network. An important issue performing such analysis is to provide precise model parameters, matching the actual equipment. One way to obtain such parameters is to derive...... them by measurements of the equipment. In this work we describe the design of a testbed enabling active measurements on up to 1 [Gb=Sec] Copper based Ethernet Switches. By use of the testbed it self, we conduct a series of tests where the precision of the testbed is estimated. We find a maximum error...

  5. Swing-up Menggunakan Energy Contol Method dan Stabilisasi Menggunakan Fuzzy-LQR pada Pendulum Cart System

    Directory of Open Access Journals (Sweden)

    Agus Lesmana

    2014-03-01

    Full Text Available Pendulum Cart System adalah suatu plant yang terdiri dari batang pendulum yang menggantung dan bersumbu pada kedua sisi kereta yang dapat bergerak pada suatu lintasan dengan sumbu vertikal. Pendulum Cart System merupakan salah satu sistem nonlinear yang sering digunakan untuk pengujian berbagai metode kontrol. Makalah ini membahas desain sistem kontrol swing-up dengan menggunakan energy control method. Setelah melakukan swing-up,  Pendulum Cart System distabilkan pada posisi 0 radian dengan menggunakan Fuzzy Linear Quadratic Regulator (LQR. Model nonlinear Pendulum Cart System direpresentasikan dalam model fuzzy Takagi-Sugeno untuk beberapa titik kerja, kemudian kontroler state feedback disusun dengan konsep Parallel Distributed Compensation (PDC menggunakan Linear Quadratic Regulator (LQR. Hasil simulasi serta implementasi menunjukkan bahwa Pendulum Cart System mampu melakukan swing-up dan stabilisasi walaupun diberikan gangguan pada saat stabilisasi.

  6. Could EBT Machines Increase Fruit and Vegetable Purchases at New York City Green Carts?

    Science.gov (United States)

    Breck, Andrew; Kiszko, Kamila; Martinez, Olivia; Abrams, Courtney; Elbel, Brian

    2017-09-21

    Residents of some low-income neighborhoods have limited access to fresh fruits and vegetables. In 2008, New York City issued new mobile fruit and vegetable cart licenses for neighborhoods with inadequate availability of fresh produce. Some of these carts were equipped with electronic benefit transfer (EBT) machines, allowing them to accept Supplemental Nutrition Assistance Program (SNAP) benefits. This article examines the association between type and quantities of fruits and vegetables purchased from mobile fruit and vegetable vendors and consumer characteristics, including payment method. Customers at 4 produce carts in the Bronx, New York, were surveyed during 3 periods in 2013 and 2014. Survey data, including purchased fruit and vegetable quantities, were analyzed using multivariable negative binomial regressions, with payment method (cash only vs EBT or EBT and cash) as the primary independent variable. Covariates included availability of EBT, vendor, and customer sociodemographic characteristics. A total of 779 adults participated in this study. Shoppers who used SNAP benefits purchased an average of 5.4 more cup equivalents of fruits and vegetables than did shoppers who paid with cash. Approximately 80% of this difference was due to higher quantities of purchased fruits. Expanding access to EBT machines at mobile produce carts may increase purchases of fruits and vegetables from these vendors.

  7. Robust Takagi-Sugeno Fuzzy Dynamic Regulator for Trajectory Tracking of a Pendulum-Cart System

    Directory of Open Access Journals (Sweden)

    Miguel A. Llama

    2015-01-01

    Full Text Available Starting from a nonlinear model for a pendulum-cart system, on which viscous friction is considered, a Takagi-Sugeno (T-S fuzzy augmented model (TSFAM as well as a TSFAM with uncertainty (TSFAMwU is proposed. Since the design of a T-S fuzzy controller is based on the T-S fuzzy model of the nonlinear system, then, to address the trajectory tracking problem of the pendulum-cart system, three T-S fuzzy controllers are proposed via parallel distributed compensation: (1 a T-S fuzzy servo controller (TSFSC designed from the TSFAM; (2 a robust TSFSC (RTSFSC designed from the TSFAMwU; and (3 a robust T-S fuzzy dynamic regulator (RTSFDR designed from the RTSFSC with the addition of a T-S fuzzy observer, which estimates cart and pendulum velocities. Both TSFAM and TSFAMwU are comprised of two fuzzy rules and designed via local approximation in fuzzy partition spaces technique. Feedback gains for the three fuzzy controllers are obtained via linear matrix inequalities approach. A swing-up controller is developed to swing the pendulum up from its pendant position to its upright position. Real-time experiments validate the effectiveness of the proposed schemes, keeping the pendulum in its upright position while the cart follows a reference signal, standing out the RTSFDR.

  8. CAR-T cells and combination therapies: What's next in the immunotherapy revolution?

    Science.gov (United States)

    Ramello, Maria C; Haura, Eric B; Abate-Daga, Daniel

    2017-12-01

    Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified T cells, which have unique pharmacokinetic properties, due to their ability to replicate and persist long-term, following a single administration. Furthermore, in the case of CAR-T cells, the use of synthetic immune receptors may impact signaling pathways involved in T cell function and survival in unexpected ways. We, herein, comment on the most salient aspects of CAR-T cell design and clinical experience in the treatment of solid tumors. In addition, we discuss different possible scenarios for combinations of CAR-T cells and other treatment modalities, with a special emphasis on kinase inhibitors, elaborating on the strategies to maximize synergism. Finally, we discuss some of the technologies that are available to explore the molecular events governing the success of these therapies. The young fields of synthetic and systems biology are likely to be major players in the advancement of CAR-T cell therapies, providing the tools and the knowledge to engineer patients' T lymphocytes into intelligent cancer-fighting micromachines. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. L'enfant et la carte au XVIIIe siècle

    Directory of Open Access Journals (Sweden)

    Bernard HUBER

    1998-12-01

    Full Text Available Les enfants ont toujours été attirés par les cartes. Au XVIIIe siècle déjà, la production d'atlas spécifiquement destinés à la jeunesse est assez abondante dans certains pays d'Europe occidentale.

  10. Fire behavior of e-tablets stored in aircraft galley carts.

    Science.gov (United States)

    2015-04-01

    The use of electronic-tablets (e-tablets) as replacements for conventional in-flight entertainment systems has gained popularity : among airlines globally. Innovative methods of storing and charging e-tablets in galley carts have been suggested or ar...

  11. La phase critique de la Carte du Ciel à Paris, 1920-1940.

    Science.gov (United States)

    Saint-Martin, A.

    2008-06-01

    Ce chapitre revient sur la "phase critique" de la Carte du Ciel à Paris, entre 1920 et 1940. Il examine en détail la crise que traverse l'astronomie française et l'Observatoire de Paris dans l'entre-deux guerres. La productivité de l'établissement parisien est jugée insuffisante et les conditions climatiques difficiles l'empêchent de développer une activité soutenue. Une délocalisation, loin de la ville, est envisagée. Dans ce contexte délicat, la légitimité de la Carte du Ciel est explicitement remise en cause. En 1930, Henri Mineur se voit confié par Benjamin Baillaud, directeur de l'Observatoire de Paris, un programme de développement de la Carte du Ciel. Il suggère la création d'un laboratoire de statistique stellaire permettant notamment d'inventorier les amas stellaires. Mineur n'est pas soutenu dans son projet et rejoint, en 1933, le service d'astrophysique. Finalement les décisions de l'Union Astronomique Internationale et les financements du CNR prolongent, dans les années 1930, les activités de la Carte du Ciel.

  12. Control of trunk motion following sudden stop perturbations during cart pushing.

    Science.gov (United States)

    Lee, Yun-Ju; Hoozemans, Marco J M; van Dieën, Jaap H

    2011-01-04

    External perturbations during pushing tasks have been suggested to be a risk factor for low-back symptoms. An experiment was designed to investigate whether self-induced and externally induced sudden stops while pushing a high inertia cart influence trunk motions, and how flexor and extensor muscles counteract these perturbations. Twelve healthy male participants pushed a 200 kg cart at shoulder height and hip height. Pushing while walking was compared to situations in which participants had to stop the cart suddenly (self-induced stop) or in which the wheels of the cart were unexpectedly blocked (externally induced stop). For the perturbed conditions, the peak values and the maximum changes from the reference condition (pushing while walking) of the external moment at L5/S1, trunk inclination and electromyographic amplitudes of trunk muscles were determined. In the self-induced stop, a voluntary trunk extension occurred. Initial responses in both stops consisted of flexor and extensor muscle cocontraction. In self-induced stops this was followed by sustained extensor activity. In the externally induced stops, an external extension moment caused a decrease in trunk inclination. The opposite directions of the internal moment and trunk motion in the externally induced stop while pushing at shoulder height may indicate insufficient active control of trunk posture. Consequently, sudden blocking of the wheels in pushing at shoulder height may put the low back at risk of mechanical injury. Copyright © 2010 Elsevier Ltd. All rights reserved.

  13. Health constraints of Cart Horses in the Dry warm, Sub-moist tepid ...

    African Journals Online (AJOL)

    The objectives of this study were to identify the major health and welfare constraints of cart horses in the dry warm, sub-moist tepid and moist cool climatic zones of Ethiopia. The study was cross sectional and a total of 837 horses were examined. Five major health problems and welfare issues were identified. Lymphangitis ...

  14. KLASIFIKASI KARAKTERISTIK KECELAKAAN LALU LINTAS DI KOTA DENPASAR DENGAN PENDEKATAN CLASSIFICATION AND REGRESSION TREES (CART

    Directory of Open Access Journals (Sweden)

    I GEDE AGUS JIWADIANA

    2015-11-01

    Full Text Available The aim of this research is to determine the classification characteristics of traffic accidents in Denpasar city in January-July 2014 by using Classification And Regression Trees (CART. Then, for determine the explanatory variables into the main classifier of CART. The result showed that optimum CART generate three terminal node. First terminal node, there are 12 people were classified as heavy traffic accident characteritics with single accident, and second terminal nodes, there are 68 people were classified as minor traffic accident characteristics by type of traffic accident front-rear, front-front, front-side, pedestrians, side-side and location of traffic accident in district road and sub-district road. For third terminal node, there are 291 people were classified as medium traffic accident characteristics by type of traffic accident front-rear, front-front, front-side, pedestrians, side-side and location of traffic accident in municipality road and explanatory variables into the main splitter to make of CART is type of traffic accident with maximum homogeneity measure of 0.03252.

  15. Neuroretinal Degeneration in HIV Patients Without Opportunistic Ocular Infections in the cART Era

    NARCIS (Netherlands)

    Demirkaya, Nazli; Wit, Ferdinand; Schlingemann, Reinier; Verbraak, Franciscus

    2015-01-01

    Subtle structural and functional retinal abnormalities, termed 'HIV-associated Neuroretinal Disorder (HIV-NRD)', have been reported in HIV patients receiving combination antiretroviral therapy (cART), without infectious retinitis or any apparent fundus abnormalities otherwise. In this review, we

  16. Assessing community resilience: A CART survey application in an impoverished urban community.

    Science.gov (United States)

    Pfefferbaum, Rose L; Pfefferbaum, Betty; Zhao, Yan D; Van Horn, Richard L; McCarter, Grady S Mack; Leonard, Michael B

    2016-01-01

    This article describes an application of the Communities Advancing Resilience Toolkit (CART) Assessment Survey which has been recognized as an important community tool to assist communities in their resilience-building efforts. Developed to assist communities in assessing their resilience to disasters and other adversities, the CART survey can be used to obtain baseline information about a community, to identify relative community strengths and challenges, and to re-examine a community after a disaster or post intervention. This article, which describes an application of the survey in a community of 5 poverty neighborhoods, illustrates the use of the instrument, explicates aspects of community resilience, and provides possible explanations for the results. The paper also demonstrates how a community agency that serves many of the functions of a broker organization can enhance community resilience. Survey results suggest various dimensions of community resilience (as represented by core CART community resilience items and CART domains) and potential predictors. Correlates included homeownership, engagement with local entities/activities, prior experience with a personal emergency or crisis while living in the neighborhood, and involvement with a community organization that focuses on building safe and caring communities through personal relationships. In addition to influencing residents' perceptions of their community, it is likely that the community organization, which served as a sponsor for this application, contributes directly to community resilience through programs and initiatives that enhance social capital and resource acquisition and mobilization.

  17. Automated anesthesia carts reduce drug recording errors in medication administrations - A single center study in the largest tertiary referral hospital in China.

    Science.gov (United States)

    Wang, Ying; Du, Yingying; Zhao, Yingying; Ren, Yang; Zhang, Wei

    2017-08-01

    To clinically evaluate a type of patented automated anesthesia cart in medication administrations in anesthesia. This was a prospectively randomized open label clinical trial. In 10 designated operating suits in the First Affiliated Hospital of Zhengzhou University, in China. 1066 cases originated from 10,812 medication administrations in anesthesia were randomized. 78 registered anesthesiologists managed the medication. The patients received medication administrations in anesthesia with either an automated or a conventional manual cart. American Society of Anesthesiologists (ASA) score, sex, duration of anesthesia and surgical specialty, errors in administration of medications (incorrect medication given (substitution), medication not given (omission) and drug recordings errors"), compliance and satisfaction were recorded. The total error rate was 7.3% with the automated anesthesia carts (1 in 14 administrations) and 11.9% with conventional manual carts (1 in 8 administrations). Automated anesthesia carts significantly reduced the drug recording error rate compared to conventional manual carts (Perrors omission errors was found between groups of automated anesthesia carts and conventional manual carts. The anesthesiologists' compliance with the automated anesthesia carts was unsatisfactory, and all the errors in medication recordings with the automated anesthesia carts were due to the incorrect use of the carts. Most of the participating anesthesiologists preferred the automated anesthesia carts (Perrors in medication administrations of anesthesia. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Integrated Testbed for Environmental Analysis of NextGen Concepts using ACES Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose the development of an analysis testbed to integrate simulation tools, such as ACES, with aviation environmental effects models, such as the Aviation...

  19. A Testbed For Validating the LHC Controls System Core Before Deployment

    CERN Document Server

    Nguyen Xuan, J

    2011-01-01

    Since the start-up of the LHC, it is crucial to carefully test core controls components before deploying them operationally. The Testbed of the CERN accelerator controls group was developed for this purpose. It contains different hardware (PPC, i386) running various operating systems (Linux and LynxOS) and core software components running on front-ends, communication middleware and client libraries. The Testbed first executes integration tests to verify that the components delivered by individual teams interoperate, and then system tests, which verify high-level, end-user functionality. It also verifies that different versions of components are compatible, which is vital, because not all parts of the operational LHC control system can be upgraded simultaneously. In addition, the Testbed can be used for performance and stress tests. Internally, the Testbed is driven by Atlassian Bamboo, a Continuous Integration server, which builds and deploys automatically new software versions into the Test...

  20. Decision Support Tool and Simulation Testbed for Airborne Spacing and Merging in Super Dense Operations Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The key innovation in this effort is the development of a decision support tool and simulation testbed for Airborne Spacing and Merging (ASM). We focus on concepts...

  1. Strategies for Fault-Tolerant, Space-Based Computing: Lessons Learned from the ARGOS Testbed

    National Research Council Canada - National Science Library

    Levellette, M. N; Wood, K. S; Wood, D. L; Beall, J. H; Shirvani, P. P; Oh, N; McCluskey, E. J

    2002-01-01

    The Advanced Space Computing and Autonomy Testbed on the ARGOS Satellite provides the first direct, on orbit comparison of a modern radiation hardened 32 bit processor with a similar COTS processor...

  2. A Simulation Testbed for Dynamic Air Corridors within the Next Generation Air Transportation System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The key innovation in this effort is the development of a simulation testbed for identifying dynamic air corridors that can increase aircraft throughput in and...

  3. Integrated Testbed for Environmental Analysis of NextGen Concepts using ACES Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The key innovation in this effort is the development of an industrial-grade analysis testbed to integrate simulation tools, such as ACES, with aviation environmental...

  4. Psychophysiological responses in women during cart pushing on different frictional walkways.

    Science.gov (United States)

    Maikala, Rammohan V; Ciriello, Vincent M; Dempsey, Patrick G; O'Brien, Niall V

    2009-10-01

    The aim of this study was to evaluate psychophysically determined acceptable forces, cardiopulmonary, and calf muscle metabolic responses in 15 workers while they pushed an instrumented cart on two walkways. In addition to the potential for increased musculoskeletal disorders in workers, pushing on various terrains is associated with occurrence of slips and falls at the workplace. Using a psychophysical approach, participants chose the maximum acceptable cart weight they could push without strain on walkways with coefficient of friction equaling 0.68 (plywood) and 0.26 (Teflon-coated.). Then, while participants pushed their psychophysically chosen cart weight for 2 hr on each walkway, horizontal and vertical forces applied on the cart handle and physiological responses were collected. Cardiopulmonary responses were measured using a telemetric metabolic cart. A tissue hemoglobin index (THI) and a tissue oxygenation index (TOI) from the right and left calf muscles were obtained using near-infrared spectroscopy. Participants generated higher horizontal forces (by 26%) on plywood than that on Teflon. Cardiopulmonary and TOI and THI responses were similar between walkways. However, greater ratios of absolute oxygen uptake per force (by 19%) and TOI per force (by 24%) on Teflon were demonstrated in the horizontal direction than on plywood. This increased muscle oxygenation-force ratio, coupled with increased oxygen uptake per force generated on Teflon, might suggest that pushing on the slippery surface results in higher metabolic demand. Findings from the present study will assist in revising previously established acceptable forces and in relating these forces to physiological responses with respect to pushing on different frictional walkways.

  5. The nucleus accumbens 5-HTR4-CART pathway ties anorexia to hyperactivity

    Science.gov (United States)

    Jean, A; Laurent, L; Bockaert, J; Charnay, Y; Dusticier, N; Nieoullon, A; Barrot, M; Neve, R; Compan, V

    2012-01-01

    In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between hyperactivity and anorexia in Anorexia nervosa. The neural underpinnings of this ‘paradox', however, are poorly elucidated. Although anorexia and hyperactivity prevail over self-preservation, both symptoms rarely exist independently, suggesting commonalities in neural pathways, most likely in the reward system. We previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (NAc), of the same transcripts stimulated in response to cocaine and amphetamine (CART) upon stimulation of the 5-HT4 receptors (5-HTR4) or MDMA (ecstasy). Here, we tested whether this pathway predisposes not only to anorexia but also to hyperactivity. Following food restriction, mice are expected to overeat. However, selecting hyperactive and addiction-related animal models, we observed that mice lacking 5-HTR1B self-imposed food restriction after deprivation and still displayed anorexia and hyperactivity after ecstasy. Decryption of the mechanisms showed a gain-of-function of 5-HTR4 in the absence of 5-HTR1B, associated with CART surplus in the NAc and not in other brain areas. NAc-5-HTR4 overexpression upregulated NAc-CART, provoked anorexia and hyperactivity. NAc-5-HTR4 knockdown or blockade reduced ecstasy-induced hyperactivity. Finally, NAc-CART knockdown suppressed hyperactivity upon stimulation of the NAc-5-HTR4. Additionally, inactivating NAc-5-HTR4 suppressed ecstasy's preference, strengthening the rewarding facet of anorexia. In conclusion, the NAc-5-HTR4/CART pathway establishes a ‘tight-junction' between anorexia and hyperactivity, suggesting the existence of a primary functional unit susceptible to limit overeating associated with resting following homeostasis rules. PMID:23233022

  6. The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity.

    Science.gov (United States)

    Jean, A; Laurent, L; Bockaert, J; Charnay, Y; Dusticier, N; Nieoullon, A; Barrot, M; Neve, R; Compan, V

    2012-12-11

    In mental diseases, the brain does not systematically adjust motor activity to feeding. Probably, the most outlined example is the association between hyperactivity and anorexia in Anorexia nervosa. The neural underpinnings of this 'paradox', however, are poorly elucidated. Although anorexia and hyperactivity prevail over self-preservation, both symptoms rarely exist independently, suggesting commonalities in neural pathways, most likely in the reward system. We previously discovered an addictive molecular facet of anorexia, involving production, in the nucleus accumbens (NAc), of the same transcripts stimulated in response to cocaine and amphetamine (CART) upon stimulation of the 5-HT(4) receptors (5-HTR(4)) or MDMA (ecstasy). Here, we tested whether this pathway predisposes not only to anorexia but also to hyperactivity. Following food restriction, mice are expected to overeat. However, selecting hyperactive and addiction-related animal models, we observed that mice lacking 5-HTR(1B) self-imposed food restriction after deprivation and still displayed anorexia and hyperactivity after ecstasy. Decryption of the mechanisms showed a gain-of-function of 5-HTR(4) in the absence of 5-HTR(1B), associated with CART surplus in the NAc and not in other brain areas. NAc-5-HTR(4) overexpression upregulated NAc-CART, provoked anorexia and hyperactivity. NAc-5-HTR(4) knockdown or blockade reduced ecstasy-induced hyperactivity. Finally, NAc-CART knockdown suppressed hyperactivity upon stimulation of the NAc-5-HTR(4). Additionally, inactivating NAc-5-HTR(4) suppressed ecstasy's preference, strengthening the rewarding facet of anorexia. In conclusion, the NAc-5-HTR(4)/CART pathway establishes a 'tight-junction' between anorexia and hyperactivity, suggesting the existence of a primary functional unit susceptible to limit overeating associated with resting following homeostasis rules.

  7. A Test-Bed of Secure Mobile Cloud Computing for Military Applications

    Science.gov (United States)

    2016-09-13

    SECURITY CLASSIFICATION OF: Many military applications have the following characteristics: they start from a mobile device (e.g., a night vision...Army Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 Test-bed, Mobile Cloud Computing, Security , Military Applications REPORT...journals: Final Report: A Test-bed of Secure Mobile Cloud Computing for Military Applications Report Title Many military applications have the

  8. Large-scale structural analysis: The structural analyst, the CSM Testbed and the NAS System

    Science.gov (United States)

    Knight, Norman F., Jr.; Mccleary, Susan L.; Macy, Steven C.; Aminpour, Mohammad A.

    1989-01-01

    The Computational Structural Mechanics (CSM) activity is developing advanced structural analysis and computational methods that exploit high-performance computers. Methods are developed in the framework of the CSM testbed software system and applied to representative complex structural analysis problems from the aerospace industry. An overview of the CSM testbed methods development environment is presented and some numerical methods developed on a CRAY-2 are described. Selected application studies performed on the NAS CRAY-2 are also summarized.

  9. Experimental Research Testbeds for Large-Scale WSNs: A Survey from the Architectural Perspective

    OpenAIRE

    Hiecheol Kim; Won-Kee Hong; Joonhyuk Yoo; Seong-eun Yoo

    2015-01-01

    Wireless sensor networks (WSNs) have a significant potential in diverse applications. In contrast to WSNs in a small-scale setting, the real-world adoption of large-scale WSNs is quite slow particularly due to the lack of robustness of protocols at all levels. Upon the demanding need for their experimental verification and evaluation, researchers have developed numerous WSN testbeds. While each individual WSN testbed contributes to the progress with its own unique innovation, still a missing ...

  10. Mounted Smartphones as Measurement and Control Platforms for Motor-Based Laboratory Test-Beds

    Directory of Open Access Journals (Sweden)

    Jared A. Frank

    2016-08-01

    Full Text Available Laboratory education in science and engineering often entails the use of test-beds equipped with costly peripherals for sensing, acquisition, storage, processing, and control of physical behavior. However, costly peripherals are no longer necessary to obtain precise measurements and achieve stable feedback control of test-beds. With smartphones performing diverse sensing and processing tasks, this study examines the feasibility of mounting smartphones directly to test-beds to exploit their embedded hardware and software in the measurement and control of the test-beds. This approach is a first step towards replacing laboratory-grade peripherals with more compact and affordable smartphone-based platforms, whose interactive user interfaces can engender wider participation and engagement from learners. Demonstrative cases are presented in which the sensing, computation, control, and user interaction with three motor-based test-beds are handled by a mounted smartphone. Results of experiments and simulations are used to validate the feasibility of mounted smartphones as measurement and feedback control platforms for motor-based laboratory test-beds, report the measurement precision and closed-loop performance achieved with such platforms, and address challenges in the development of platforms to maintain system stability.

  11. Mounted Smartphones as Measurement and Control Platforms for Motor-Based Laboratory Test-Beds

    Science.gov (United States)

    Frank, Jared A.; Brill, Anthony; Kapila, Vikram

    2016-01-01

    Laboratory education in science and engineering often entails the use of test-beds equipped with costly peripherals for sensing, acquisition, storage, processing, and control of physical behavior. However, costly peripherals are no longer necessary to obtain precise measurements and achieve stable feedback control of test-beds. With smartphones performing diverse sensing and processing tasks, this study examines the feasibility of mounting smartphones directly to test-beds to exploit their embedded hardware and software in the measurement and control of the test-beds. This approach is a first step towards replacing laboratory-grade peripherals with more compact and affordable smartphone-based platforms, whose interactive user interfaces can engender wider participation and engagement from learners. Demonstrative cases are presented in which the sensing, computation, control, and user interaction with three motor-based test-beds are handled by a mounted smartphone. Results of experiments and simulations are used to validate the feasibility of mounted smartphones as measurement and feedback control platforms for motor-based laboratory test-beds, report the measurement precision and closed-loop performance achieved with such platforms, and address challenges in the development of platforms to maintain system stability. PMID:27556464

  12. CART neuropeptide modulates the extended amygdalar CeA-vBNST circuit to gate expression of innate fear.

    Science.gov (United States)

    Rale, Abhishek; Shendye, Ninad; Bodas, Devika S; Subhedar, Nishikant; Ghose, Aurnab

    2017-11-01

    Innate fear is critical for the survival of animals and is under tight homeostatic control. Deregulation of innate fear processing is thought to underlie pathological phenotypes including, phobias and panic disorders. Although central processing of conditioned fear has been extensively studied, the circuitry and regulatory mechanisms subserving innate fear remain relatively poorly defined. In this study, we identify cocaine- and amphetamine-regulated transcript (CART) neuropeptide signaling in the central amygdala (CeA) - ventral bed nucleus of stria terminalis (vBNST) axis as a key modulator of innate fear expression. 2,4,5-trimethyl-3-thiazoline (TMT), a component of fox faeces, induces a freezing response whose intensity is regulated by the extent of CART-signaling in the CeA neurons. Abrogation of CART activity in the CeA attenuates the freezing response and reduces activation of vBNST neurons. Conversely, ectopically elevated CART signaling in the CeA potentiates the fear response concomitant with enhanced vBNST activation. We show that local levels of CART signaling modulate the activation of CeA neurons by NMDA receptor-mediated glutamatergic inputs, in turn, regulating activity in the vBNST. This study identifies the extended amygdalar CeA-vBNST circuit as a CART modulated axis encoding innate fear. CART signaling regulates the glutamatergic excitatory drive in the CeA-vBNST circuit, in turn, gating the expression of the freezing response to TMT. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward.

    Science.gov (United States)

    Li, Jian; Li, Wenwen; Huang, Kejia; Zhang, Yang; Kupfer, Gary; Zhao, Qi

    2018-02-13

    Recently, the US Food and Drug Administration (FDA) approved the first chimeric antigen receptor T cell (CAR-T) therapy for the treatment CD19-positive B cell acute lymphoblastic leukemia. While CAR-T has achieved remarkable success in the treatment of hematopoietic malignancies, whether it can benefit solid tumor patients to the same extent is still uncertain. Even though hundreds of clinical trials are undergoing exploring a variety of tumor-associated antigens (TAA), no such antigen with comparable properties like CD19 has yet been identified regarding solid tumors CAR-T immunotherapy. Inefficient T cell trafficking, immunosuppressive tumor microenvironment, suboptimal antigen recognition specificity, and lack of safety control are currently considered as the main obstacles in solid tumor CAR-T therapy. Here, we reviewed the solid tumor CAR-T clinical trials, emphasizing the studies with published results. We further discussed the challenges that CAR-T is facing for solid tumor treatment and proposed potential strategies to improve the efficacy of CAR-T as promising immunotherapy.

  14. Designing an autonomous helicopter testbed: From conception through implementation

    Science.gov (United States)

    Garcia, Richard D.

    Miniature Unmanned Aerial Vehicles (UAVs) are currently being researched for a wide range of tasks, including search and rescue, surveillance, reconnaissance, traffic monitoring, fire detection, pipe and electrical line inspection, and border patrol to name only a few of the application domains. Although small/miniature UAVs, including both Vertical Takeoff and Landing (VTOL) vehicles and small helicopters, have shown great potential in both civilian and military domains, including research and development, integration, prototyping, and field testing, these unmanned systems/vehicles are limited to only a handful of university labs. For VTOL type aircraft the number is less than fifteen worldwide! This lack of development is due to both the extensive time and cost required to design, integrate and test a fully operational prototype as well as the shortcomings of published materials to fully describe how to design and build a "complete" and "operational" prototype system. This dissertation overcomes existing barriers and limitations by describing and presenting in great detail every technical aspect of designing and integrating a small UAV helicopter including the on-board navigation controller, capable of fully autonomous takeoff, waypoint navigation, and landing. The presented research goes beyond previous works by designing the system as a testbed vehicle. This design aims to provide a general framework that will not only allow researchers the ability to supplement the system with new technologies but will also allow researchers to add innovation to the vehicle itself. Examples include modification or replacement of controllers, updated filtering and fusion techniques, addition or replacement of sensors, vision algorithms, Operating Systems (OS) changes or replacements, and platform modification or replacement. This is supported by the testbed's design to not only adhere to the technology it currently utilizes but to be general enough to adhere to a multitude of

  15. EM61 MK2 Cart Data Collection and Analysis

    Science.gov (United States)

    2011-06-01

    the site consists of hills and mountains with three categories of soils occurring within: alluvial plains and fans , terrace soils, and hill/mountain...soils. Occurring mainly adjacent to stream channels are the soils associated with the alluvial plains and fans . Slope is nearly level to moderately...encountered. Data collection was completed on schedule across the entire 10 acre demonstration area. This dynamic survey data was used for target selection

  16. La carte postale coloniale dans l’album : Nona des sables, un château de cartes mémorielles

    Directory of Open Access Journals (Sweden)

    Anne Schneider

    2012-01-01

    Full Text Available L’album Nona des sables de Françoise Kérisel raconte la recherche mémorielle de la petite Manuela interrogeant sa grand-mère Nona sur son passé dans son Algérie natale. À partir de cartes postales coloniales qui se superposent au texte de l’album, elle renoue petit à petit avec son histoire familiale et algérienne et son identité mixte en croisant les approches iconographiques et langagières.

  17. Event metadata records as a testbed for scalable data mining

    Science.gov (United States)

    van Gemmeren, P.; Malon, D.

    2010-04-01

    At a data rate of 200 hertz, event metadata records ("TAGs," in ATLAS parlance) provide fertile grounds for development and evaluation of tools for scalable data mining. It is easy, of course, to apply HEP-specific selection or classification rules to event records and to label such an exercise "data mining," but our interest is different. Advanced statistical methods and tools such as classification, association rule mining, and cluster analysis are common outside the high energy physics community. These tools can prove useful, not for discovery physics, but for learning about our data, our detector, and our software. A fixed and relatively simple schema makes TAG export to other storage technologies such as HDF5 straightforward. This simplifies the task of exploiting very-large-scale parallel platforms such as Argonne National Laboratory's BlueGene/P, currently the largest supercomputer in the world for open science, in the development of scalable tools for data mining. Using a domain-neutral scientific data format may also enable us to take advantage of existing data mining components from other communities. There is, further, a substantial literature on the topic of one-pass algorithms and stream mining techniques, and such tools may be inserted naturally at various points in the event data processing and distribution chain. This paper describes early experience with event metadata records from ATLAS simulation and commissioning as a testbed for scalable data mining tool development and evaluation.

  18. A satellite orbital testbed for SATCOM using mobile robots

    Science.gov (United States)

    Shen, Dan; Lu, Wenjie; Wang, Zhonghai; Jia, Bin; Wang, Gang; Wang, Tao; Chen, Genshe; Blasch, Erik; Pham, Khanh

    2016-05-01

    This paper develops and evaluates a satellite orbital testbed (SOT) for satellite communications (SATCOM). SOT can emulate the 3D satellite orbit using the omni-wheeled robots and a robotic arm. The 3D motion of satellite is partitioned into the movements in the equatorial plane and the up-down motions in the vertical plane. The former actions are emulated by omni-wheeled robots while the up-down motions are performed by a stepped-motor-controlled-ball along a rod (robotic arm), which is attached to the robot. The emulated satellite positions will go to the measure model, whose results will be used to perform multiple space object tracking. Then the tracking results will go to the maneuver detection and collision alert. The satellite maneuver commands will be translated to robots commands and robotic arm commands. In SATCOM, the effects of jamming depend on the range and angles of the positions of satellite transponder relative to the jamming satellite. We extend the SOT to include USRP transceivers. In the extended SOT, the relative ranges and angles are implemented using omni-wheeled robots and robotic arms.

  19. Aerospace Engineering Systems and the Advanced Design Technologies Testbed Experience

    Science.gov (United States)

    VanDalsem, William R.; Livingston, Mary E.; Melton, John E.; Torres, Francisco J.; Stremel, Paul M.

    1999-01-01

    Continuous improvement of aerospace product development processes is a driving requirement across much of the aerospace community. As up to 90% of the cost of an aerospace product is committed during the first 10% of the development cycle, there is a strong emphasis on capturing, creating, and communicating better information (both requirements and performance) early in the product development process. The community has responded by pursuing the development of computer-based systems designed to enhance the decision-making capabilities of product development individuals and teams. Recently, the historical foci on sharing the geometrical representation and on configuration management are being augmented: 1) Physics-based analysis tools for filling the design space database; 2) Distributed computational resources to reduce response time and cost; 3) Web-based technologies to relieve machine-dependence; and 4) Artificial intelligence technologies to accelerate processes and reduce process variability. The Advanced Design Technologies Testbed (ADTT) activity at NASA Ames Research Center was initiated to study the strengths and weaknesses of the technologies supporting each of these trends, as well as the overall impact of the combination of these trends on a product development event. Lessons learned and recommendations for future activities are reported.

  20. Instrument deployment testbed: For planetary surface geophysical exploration

    Science.gov (United States)

    Trebi-Ollennu, A.; Rankin, A. L.; Cheng, Yang; Tso, K. S.; Deen, R. G.; Aghazarian, H.; Kulczycki, E. A.; Bonitz, R. G.; Alkalai, L.

    This paper describes a high fidelity mission concept systems testbed at JPL that was used to support the InSight (Interior Exploration Using Seismic Investigations, Geodesy, and Heat Transport) mission concept study. The InSight mission would conduct geophysical exploration of Mars' interior using three instruments 1. SEIS seismometer monitors seismic activity and tidal displacements; 2. RISE X-band radio Doppler tracking experiment measures rotational variations; and 3. HP3: Heat-flow and Physical Properties Probe determines the geothermal heat flux. CNES contributes SEIS and DLR contributes HP3. The measurements from these instruments would yield information about processes that occurred during the initial accretion of the planet, the formation and differentiation of its core, crust, and mantle, and subsequent evolution of its interior. The SEIS and HP3 instruments will be deployed to the surface of Mars using a robotic arm similar to the robotic arm used on the Mars Phoenix Lander mission and operational experience inherited from Phoenix and MER. The SEIS and HP3 will be monitored every three hours for one Mars year, with no ground-in-the-loop interaction required. InSight was one of three proposed missions selected by NASA Discovery Program in May 2011 for funding to conduct preliminary design studies and analyses. InSight was selected in August 2012 as the 12th mission in the NASA Discovery Program.

  1. TORCH Computational Reference Kernels - A Testbed for Computer Science Research

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, Alex; Williams, Samuel Webb; Madduri, Kamesh; Ibrahim, Khaled; Bailey, David H.; Demmel, James W.; Strohmaier, Erich

    2010-12-02

    For decades, computer scientists have sought guidance on how to evolve architectures, languages, and programming models in order to improve application performance, efficiency, and productivity. Unfortunately, without overarching advice about future directions in these areas, individual guidance is inferred from the existing software/hardware ecosystem, and each discipline often conducts their research independently assuming all other technologies remain fixed. In today's rapidly evolving world of on-chip parallelism, isolated and iterative improvements to performance may miss superior solutions in the same way gradient descent optimization techniques may get stuck in local minima. To combat this, we present TORCH: A Testbed for Optimization ResearCH. These computational reference kernels define the core problems of interest in scientific computing without mandating a specific language, algorithm, programming model, or implementation. To compliment the kernel (problem) definitions, we provide a set of algorithmically-expressed verification tests that can be used to verify a hardware/software co-designed solution produces an acceptable answer. Finally, to provide some illumination as to how researchers have implemented solutions to these problems in the past, we provide a set of reference implementations in C and MATLAB.

  2. Digital Preservation Theory and Application: Transcontinental Persistent Archives Testbed Activity

    Directory of Open Access Journals (Sweden)

    Paul Watry

    2007-12-01

    Full Text Available The National Archives and Records Administration (NARA and EU SHAMAN projects are working with multiple research institutions on tools and technologies that will supply a comprehensive, systematic, and dynamic means for preserving virtually any type of electronic record, free from dependence on any specific hardware or software. This paper describes the joint development work between the University of Liverpool and the San Diego Supercomputer Center (SDSC at the University of California, San Diego on the NARA and SHAMAN prototypes. The aim is to provide technologies in support of the required generic data management infrastructure. We describe a Theory of Preservation that quantifies how communication can be accomplished when future technologies are different from those available at present. This includes not only different hardware and software, but also different standards for encoding information. We describe the concept of a “digital ontology” to characterize preservation processes; this is an advance on the current OAIS Reference Model of providing representation information about records. To realize a comprehensive Theory of Preservation, we describe the ongoing integration of distributed shared collection management technologies, digital library browsing, and presentation technologies for the NARA and SHAMAN Persistent Archive Testbeds.

  3. Biosensing Test-Bed Using Electrochemically Deposited Reduced Graphene Oxide.

    Science.gov (United States)

    Bhardwaj, Sheetal K; Yadav, Premlata; Ghosh, Subhasis; Basu, Tinku; Mahapatro, Ajit K

    2016-09-21

    The development of an efficient test-bed for biosensors requires stable surfaces, capable of interacting with the functional groups present in bioentities. This work demonstrates the formation of highly stable electrochemically reduced graphene oxide (ERGO) thin films reproducibly on indium tin oxide (ITO)-coated glass substrates using a reliable technique through 60 s chronoamperometric reduction of a colloidal suspension maintained at neutral pH containing graphene oxide in deionized water. Structural optimization and biocompatible interactions of the resulting closely packed and uniformly distributed ERGO flakes on ITO surfaces (ERGO/ITO) are characterized using various microscopic and spectroscopic tools. Lipase enzyme is immobilized on the ERGO surface in the presence of ethyl-3-[3-(dimethylamino)propyl]carbodimide and N-hydroxysuccinimide for the detection of triglyceride in a tributyrin (TBN) solution. The ERGO/ITO surfaces prepared using the current technique indicate the noticeable detection of TBN, a source of triglycerides, at a sensitivity of 37 pA mg dL(-1) cm(-2) in the linear range from 50 to 300 mg dL(-1) with a response time of 12 s. The low apparent Michaelies-Menten constant of 0.28 mM suggests high enzyme affinity to TBN. The currently developed fast, simple, highly reproducible, and reliable technique for the formation of an ERGO electrode could be routinely utilized as a test bed for the detection of clinically active bioentities.

  4. Event metadata records as a testbed for scalable data mining

    Energy Technology Data Exchange (ETDEWEB)

    Gemmeren, P van; Malon, D, E-mail: gemmeren@anl.go [Argonne National Laboratory, Argonne, Illinois 60439 (United States)

    2010-04-01

    At a data rate of 200 hertz, event metadata records ('TAGs,' in ATLAS parlance) provide fertile grounds for development and evaluation of tools for scalable data mining. It is easy, of course, to apply HEP-specific selection or classification rules to event records and to label such an exercise 'data mining,' but our interest is different. Advanced statistical methods and tools such as classification, association rule mining, and cluster analysis are common outside the high energy physics community. These tools can prove useful, not for discovery physics, but for learning about our data, our detector, and our software. A fixed and relatively simple schema makes TAG export to other storage technologies such as HDF5 straightforward. This simplifies the task of exploiting very-large-scale parallel platforms such as Argonne National Laboratory's BlueGene/P, currently the largest supercomputer in the world for open science, in the development of scalable tools for data mining. Using a domain-neutral scientific data format may also enable us to take advantage of existing data mining components from other communities. There is, further, a substantial literature on the topic of one-pass algorithms and stream mining techniques, and such tools may be inserted naturally at various points in the event data processing and distribution chain. This paper describes early experience with event metadata records from ATLAS simulation and commissioning as a testbed for scalable data mining tool development and evaluation.

  5. Tower-based greenhouse gas measurement network design—The National Institute of Standards and Technology North East Corridor Testbed

    Science.gov (United States)

    Lopez-Coto, Israel; Ghosh, Subhomoy; Prasad, Kuldeep; Whetstone, James

    2017-09-01

    The North-East Corridor (NEC) Testbed project is the 3rd of three NIST (National Institute of Standards and Technology) greenhouse gas emissions testbeds designed to advance greenhouse gas measurements capabilities. A design approach for a dense observing network combined with atmospheric inversion methodologies is described. The Advanced Research Weather Research and Forecasting Model with the Stochastic Time-Inverted Lagrangian Transport model were used to derive the sensitivity of hypothetical observations to surface greenhouse gas emissions (footprints). Unlike other network design algorithms, an iterative selection algorithm, based on a k-means clustering method, was applied to minimize the similarities between the temporal response of each site and maximize sensitivity to the urban emissions contribution. Once a network was selected, a synthetic inversion Bayesian Kalman filter was used to evaluate observing system performance. We present the performances of various measurement network configurations consisting of differing numbers of towers and tower locations. Results show that an overly spatially compact network has decreased spatial coverage, as the spatial information added per site is then suboptimal as to cover the largest possible area, whilst networks dispersed too broadly lose capabilities of constraining flux uncertainties. In addition, we explore the possibility of using a very high density network of lower cost and performance sensors characterized by larger uncertainties and temporal drift. Analysis convergence is faster with a large number of observing locations, reducing the response time of the filter. Larger uncertainties in the observations implies lower values of uncertainty reduction. On the other hand, the drift is a bias in nature, which is added to the observations and, therefore, biasing the retrieved fluxes.

  6. Investigation on Superior Performance by Fractional Controller for Cart-Servo Laboratory Set-Up

    Directory of Open Access Journals (Sweden)

    Ameya Anil Kesarkar

    2014-01-01

    Full Text Available In this paper, an investigation is made on the superiority of fractional PID controller (PI^alpha D^beta over conventional PID for the cart-servo laboratory set-up. The designed controllers are optimum in the sense of Integral Absolute Error (IAE and Integral Square Error (ISE. The paper contributes in three aspects: 1 Acquiring nonlinear mathematical model for the cart-servo laboratory set-up, 2 Designing fractional and integer order PID for minimizing IAE, ISE, 3 Analyzing the performance of designed controllers for simulated plant model as well as real plant. The results show a significantly superior performance by PI^alpha D^beta as compared to the conventional PID controller.

  7. Les racines historiques d'une carte géomorphologique actuelle du Chili

    Directory of Open Access Journals (Sweden)

    Jean-Pierre BERGOEING

    1991-03-01

    Full Text Available L’auteur décrit le paysage aride du nord du Chili et du sud du Pérou à travers trois cartes du XVIIIe siècle, provenant des Archives des Indes à Séville et du Musée de la Marine de Madrid. La première, générale, datant de 1791, permet de retracer les principales unités du relief. La deuxième de 1764, dessine un détail de la côte à plus grande échelle, au port d’Iquique. La troisième carte, de 1765, décrit les différents aspects physiques de la pampa du Tamarugal.

  8. One-dimensional collision carts computer model and its design ideas for productive experiential learning

    Science.gov (United States)

    Wee, Loo Kang

    2012-05-01

    We develop an Easy Java Simulation (EJS) model for students to experience the physics of idealized one-dimensional collision carts. The physics model is described and simulated by both continuous dynamics and discrete transition during collision. In designing the simulations, we discuss briefly three pedagogical considerations namely (1) a consistent simulation world view with a pen and paper representation, (2) a data table, scientific graphs and symbolic mathematical representations for ease of data collection and multiple representational visualizations and (3) a game for simple concept testing that can further support learning. We also suggest using a physical world setup augmented by simulation by highlighting three advantages of real collision carts equipment such as a tacit 3D experience, random errors in measurement and the conceptual significance of conservation of momentum applied to just before and after collision. General feedback from the students has been relatively positive, and we hope teachers will find the simulation useful in their own classes.

  9. Integrating classification and regression tree (CART) with GIS for assessment of heavy metals pollution.

    Science.gov (United States)

    Cheng, Wei; Zhang, Xiuying; Wang, Ke; Dai, Xuelong

    2009-11-01

    The classification and regression tree (CART) model integrated with geographical information systems and the assessment of heavy-metals pollution system was developed to assess the heavy metals pollution in Fuyang, Zhejiang, China. The integration of the decision tree model with ArcGIS Engine 9 using a COM implementation in Microsoft Visual Basic 6.0 provided an approach for assessing the spatial distribution of soil Zn content with high predictive accuracy. The Zn concentration classes estimated by CART assigned the right classes with an accuracy of near 90%. This is a great improvement compared to the ordinary Kriging method for the spatial autocorrelation of the study area severely destroyed by human activities. Also, it can be used to investigate the inter-relationships between the heavy metals pollution and environmental and anthropogenic variables. Moreover, the research presents model predictions over space for further applications and investigations.

  10. One-dimensional collision carts computer model and its design ideas for productive experiential learning

    CERN Document Server

    Wee, Loo Kang

    2012-01-01

    We develop an Easy Java Simulation (EJS) model for students to experience the physics of idealized one-dimensional collision carts. The physics model is described and simulated by both continuous dynamics and discrete transition during collision. In the field of designing computer simulations, we discuss briefly three pedagogical considerations such as 1) consistent simulation world view with pen paper representation, 2) data table, scientific graphs and symbolic mathematical representations for ease of data collection and multiple representational visualizations and 3) game for simple concept testing that can further support learning. We also suggest using physical world setup to be augmented complimentarily with simulation while highlighting three advantages of real collision carts equipment like tacit 3D experience, random errors in measurement and conceptual significance of conservation of momentum applied to just before and after collision. General feedback from the students has been relatively positive,...

  11. Etablissement et utilisation de la carte génétique porcine

    OpenAIRE

    Bidanel, Jean Pierre; Bonneau, M.; Chardon, P.; Elsen, Jean Michel; Gellin, J; Le Roy, Pascale; Milan, Denis; Ollivier, L

    1996-01-01

    Des programmes de cartographie des génomes des principales espèces animales d’intérêt économique se sont développés depuis quelques années. Cet article fait le point sur l’état d’avancement et les perspectives d’utilisation de la carte génétique porcine. Après une présentation des principes généraux de la cartographie génétique, les résultats des principaux programmes de cartographie du génome porcin sont présentés. Différentes perspectives d’utilisation des cartes génétiques sont ensuite évo...

  12. La carte, outil de diagnostic et de prospective pour les politiques scolaires

    Directory of Open Access Journals (Sweden)

    Patrice Caro

    2006-07-01

    Full Text Available Une étude de la localisation de nouveaux collèges dans le bassin de formation de Gap, en croissance démographique, montre que la carte constitue un robuste outil de diagnostic et de prospective pour les politiques scolaires. Tout d’abord, la carte, outil de recherche, mesure l’accessibilité des collèges et leurs aires de recrutement. Puis, vecteur de communication entre acteurs, elle «donne à voir», en le matérialisant, le territoire scolaire aux élus en charge des collèges, en modifiant leurs représentations de l’espace. Enfin, elle permet d’asseoir des scénarios.

  13. GIS and Landscape Analysis, or the cart before the horse?

    Directory of Open Access Journals (Sweden)

    Caroline Phillips

    2004-11-01

    Full Text Available Spatial analysis has traditionally considered settlements in relation to each other and aspects of topography. Criticisms of environmental determinism, and identification of problems with site data and analytical models, have followed. Transferring spatial analysis to a GIS platform has not resolved these concerns. This article highlights the fact that there are cultural assumptions within spatial analyses, through examining the land-use systems practised by New Zealand Māori, and argues that models based on modern European land use are not necessarily appropriate for other times and cultures. This test case also supports the contextual archaeology definition of landscape as a dynamic inclusive system between people and land. It is concluded that the resolution of such problems, especially when analysing societies with a recent ethnography or history, requires a landscape approach together with multi-disciplinary data and the further development of dynamic modelling and simulation through GIS.

  14. Enterobacteriaceae and related organisms isolated from nest run cart shelves in commercial shell egg processing facilities.

    Science.gov (United States)

    Musgrove, M T; Jones, D R; Shaw, J D; Sheppard, M; Harrison, M A

    2009-10-01

    Enterobacteriaceae, including Salmonella, may be recovered from foods and processing facilities. High levels of Enterobacteriaceae in the processing plant environment can be an indication of inadequate sanitation. This experiment was designed to determine if nest run egg carts serve as reservoirs for Enterobacteriaceae. Eggs that are produced by hens not housed in buildings connected to the processing plant are referred to as nest run. Many of these eggs are transported to the plant on carts to be processed. Two plants in the southeastern United States were sampled. On each of 3 visits, 5 shelves on each of 5 carts were sampled (n=25/visit). A 12x12 cm area on each shelf was swabbed with a sterile gauze pad moistened with PBS and transported on ice back to the laboratory. Enterobacteriaceae were enumerated using violet red bile glucose agar incubated at 37 degrees C for 24 h. There was 100% prevalence for Enterobacteriaceae at plant A with an average 3.8 log10 cfu/mL swab diluent. Plant B had 90% prevalence for Enterobacteriaceae with an average 3.2 log10 cfu/mL swab diluent. Two randomly selected isolates from each positive sample were recultured 3 times to increase the likelihood of clonality and were then identified biochemically. Of the 124 isolates analyzed, genera identified were Citrobacter spp., Escherichia spp., Enterobacter spp., Klebsiella spp., Hafnia spp., Kluyvera spp., Leclercia spp., and Salmonella spp. Pseudomonas spp. was the only non-Enterobacteriaceae identified by our methods. This work demonstrates that nest run egg carts serve as reservoirs for Enterobacteriaceae in the shell egg processing environment.

  15. Shopper marketing nutrition interventions: Social norms on grocery carts increase produce spending without increasing shopper budgets☆

    Science.gov (United States)

    Payne, Collin R.; Niculescu, Mihai; Just, David R.; Kelly, Michael P.

    2015-01-01

    Objectives We assessed the efficacy of an easy-to-implement shopper marketing nutrition intervention in a pilot and two additional studies to increase produce demand without decreasing store profitability or increasing shopper budgets. Methods We created grocery cart placards that detailed the number of produce items purchased (i.e., descriptive norm) at particular stores (i.e., provincial norm). The effect of these placards on produce spending was assessed across 971,706 individual person grocery store transactions aggregated by day. The pilot study designated a baseline period (in both control and intervention store) followed by installation of grocery cart placards (in the intervention store) for two weeks. The pilot study was conducted in Texas in 2012. In two additional stores, we designated baseline periods followed by 28 days of the same grocery cart placard intervention as in the pilot. Additional interventions were conducted in New Mexico in 2013. Results The pilot study resulted in a significant difference between average produce spending per day per person across treatment periods (i.e., intervention versus same time period in control) (16%) and the difference between average produce spending per day per person across stores in the control periods (4%); Furthermore, the same intervention in two additional stores resulted in significant produce spending increases of 12.4% and 7.5% per day per person respectively. In all stores, total spending did not change. Conclusions Descriptive and provincial social norm messages (i.e., on grocery cart placards) may be an overlooked tool to increase produce demand without decreasing store profitability and increasing shopper budgets. PMID:26844084

  16. Pendekatan Cart untuk Mendapatkan Faktor yang Mempengaruhi Terjangkitnya Penyakit Demam Tifoid di Aceh Utara

    Directory of Open Access Journals (Sweden)

    Dina Yuanita

    2010-05-01

    research conducted to find factors that influence the outbreak of typhoid fever in NAD. research using the CART Method. The results of the analysis indicate that the main factor causing typhoid fever was drinking water reservoirs. The other factors are waste water reservoirs, the physical quality of drinking water, a habit washing hands with soap before eating, the bowel, the dump, gender, socioeconomic status, habits of washing hands with soap after defecation and health education.

  17. L'eau en Franche-Comté: deux cartes pour poser des questions

    Directory of Open Access Journals (Sweden)

    Daniel JOLY

    1993-12-01

    Full Text Available Quatre couches d’information d’une banque de données ont été croisées pour fournir deux cartes prospectives. Elles montrent les zones qui poseront de plus en plus de problèmes pour la qualité de l’eau et les rejets non contrôlés.

  18. Using Classification and Regression Trees (CART) to Identify Prescribing Thresholds for Cardiovascular Disease.

    Science.gov (United States)

    Schilling, Chris; Mortimer, Duncan; Dalziel, Kim; Heeley, Emma; Chalmers, John; Clarke, Philip

    2016-02-01

    Many guidelines for clinical decisions are hierarchical and nonlinear. Evaluating if these guidelines are used in practice requires methods that can identify such structures and thresholds. Classification and regression trees (CART) were used to analyse prescribing patterns of Australian general practitioners (GPs) for the primary prevention of cardiovascular disease (CVD). Our aim was to identify if GPs use absolute risk (AR) guidelines in favour of individual risk factors to inform their prescribing decisions of lipid-lowering medications. We employed administrative prescribing information that is linked to patient-level data from a clinical assessment and patient survey (the AusHeart Study), and assessed prescribing of lipid-lowering medications over a 12-month period for patients (n = 1903) who were not using such medications prior to recruitment. CART models were developed to explain prescribing practice. Out-of-sample performance was evaluated using receiver operating characteristic (ROC) curves, and optimised via pruning. We found that individual risk factors (low-density lipoprotein, diabetes, triglycerides and a history of CVD), GP-estimated rather than Framingham AR, and sociodemographic factors (household income, education) were the predominant drivers of GP prescribing. However, sociodemographic factors and some individual risk factors (triglycerides and CVD history) only become relevant for patients with a particular profile of other risk factors. The ROC area under the curve was 0.63 (95% confidence interval [CI] 0.60-0.64). There is little evidence that AR guidelines recommended by the National Heart Foundation and National Vascular Disease Prevention Alliance, or conditional individual risk eligibility guidelines from the Pharmaceutical Benefits Scheme, are adopted in prescribing practice. The hierarchy of conditional relationships between risk factors and socioeconomic factors identified by CART provides new insights into prescribing decisions

  19. Sequential Vacc-4x and romidepsin during combination antiretroviral therapy (cART)

    DEFF Research Database (Denmark)

    Tapia, G; Højen, J F; Ökvist, M

    2017-01-01

    -cell responses following Vacc-4x/rhuGM-CSF immunotherapy in relation to virological outcomes on the HIV reservoir. METHODS: This study, conducted in Aarhus, Denmark, enrolled participants (n = 20) with CD4>500 cells/mm(3) on cART. Six Vacc-4x (1.2 mg) intradermal immunizations using rhuGM-CSF (60 μg) as adjuvant...

  20. Registro de los cartógrafos medievales activos en el puerto de Mallorca

    Directory of Open Access Journals (Sweden)

    Llompart, Gabriel

    1997-12-01

    Full Text Available In medieval times, with the opening of the Atlantic trading routes at the beginning of the 14th century, the port of the Ciutat de Mallorques became important as the base of a gathering of both cartographers and copiers of maps. Today these maps are dispersed in museums throughout the world. Until the present day, these early map makers were known only through their works. Presented here is the first register of the "maestros" of navigational charts who worked in the "port of Mallorca". The documentation is taken from local notarial and administrative sources, all of which help the better clarification of their names, birthplaces, their Sitz im Leben and their methods of production, which were later surpassed and improved by the advent of the modern printing press.[fr] Le port de Ciutat de Mallorques fût très important pour l'histoire de la cartographie médiévale, parce-qu'un certain nombre de dessinateurs et copistes de cartes s'établirent là au commencement du XIV siècle, en raison de l'ouverture de la route atlantique. Maintenant, ces cartes se trouvent dispersées en diferents musées par tout le monde. Les auteurs de ces cartes étaient connus et datés jusqu'aujourd'hui à travers ses ouvrages. Dans cet article nous est donné un premier registre des maîtres de cartes de naviguer que travaillèrent au port de Majorque, provenant de sources locales, notariales et administratives, que nous permettent d'eclircir leurs noms, leur date de naissance leur Sitz im Leben et leurs méthodes de travail, peu après débordés et dépassés par la presse moderne.

  1. Risk factor analysis and spatiotemporal CART model of cryptosporidiosis in Queensland, Australia

    Directory of Open Access Journals (Sweden)

    Mengersen Kerrie

    2010-10-01

    Full Text Available Abstract Background It remains unclear whether it is possible to develop a spatiotemporal epidemic prediction model for cryptosporidiosis disease. This paper examined the impact of social economic and weather factors on cryptosporidiosis and explored the possibility of developing such a model using social economic and weather data in Queensland, Australia. Methods Data on weather variables, notified cryptosporidiosis cases and social economic factors in Queensland were supplied by the Australian Bureau of Meteorology, Queensland Department of Health, and Australian Bureau of Statistics, respectively. Three-stage spatiotemporal classification and regression tree (CART models were developed to examine the association between social economic and weather factors and monthly incidence of cryptosporidiosis in Queensland, Australia. The spatiotemporal CART model was used for predicting the outbreak of cryptosporidiosis in Queensland, Australia. Results The results of the classification tree model (with incidence rates defined as binary presence/absence showed that there was an 87% chance of an occurrence of cryptosporidiosis in a local government area (LGA if the socio-economic index for the area (SEIFA exceeded 1021, while the results of regression tree model (based on non-zero incidence rates show when SEIFA was between 892 and 945, and temperature exceeded 32°C, the relative risk (RR of cryptosporidiosis was 3.9 (mean morbidity: 390.6/100,000, standard deviation (SD: 310.5, compared to monthly average incidence of cryptosporidiosis. When SEIFA was less than 892 the RR of cryptosporidiosis was 4.3 (mean morbidity: 426.8/100,000, SD: 319.2. A prediction map for the cryptosporidiosis outbreak was made according to the outputs of spatiotemporal CART models. Conclusions The results of this study suggest that spatiotemporal CART models based on social economic and weather variables can be used for predicting the outbreak of cryptosporidiosis in

  2. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

    Science.gov (United States)

    Rodgers, David T.; Mazagova, Magdalena; Hampton, Eric N.; Cao, Yu; Ramadoss, Nitya S.; Hardy, Ian R.; Schulman, Andrew; Du, Juanjuan; Wang, Feng; Singer, Oded; Ma, Jennifer; Nunez, Vanessa; Shen, Jiayin; Woods, Ashley K.; Wright, Timothy M.; Schultz, Peter G.; Kim, Chan Hyuk; Young, Travis S.

    2016-01-01

    Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related to the inability to control CAR-T cells once infused into the patient remain a significant challenge. Here we report the engineering of recombinant antibody-based bifunctional switches that consist of a tumor antigen-specific Fab molecule engrafted with a peptide neo-epitope, which is bound exclusively by a peptide-specific switchable CAR-T cell (sCAR-T). The switch redirects the activity of the bio-orthogonal sCAR-T cells through the selective formation of immunological synapses, in which the sCAR-T cell, switch, and target cell interact in a structurally defined and temporally controlled manner. Optimized switches specific for CD19 controlled the activity, tissue-homing, cytokine release, and phenotype of sCAR-T cells in a dose-titratable manner in a Nalm-6 xenograft rodent model of B-cell leukemia. The sCAR–T-cell dosing regimen could be tuned to provide efficacy comparable to the corresponding conventional CART-19, but with lower cytokine levels, thereby offering a method of mitigating cytokine release syndrome in clinical translation. Furthermore, we demonstrate that this methodology is readily adaptable to targeting CD20 on cancer cells using the same sCAR-T cell, suggesting that this approach may be broadly applicable to heterogeneous and resistant tumor populations, as well as other liquid and solid tumor antigens. PMID:26759369

  3. CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth

    OpenAIRE

    Golubovskaya, Vita; Berahovich, Robert; Zhou, Hua; Xu, Shirley; Harto, Hizkia; Li, Le; Chao, Cheng-Chi; Mao, Mike Ming; Wu, Lijun

    2017-01-01

    CD47 is a glycoprotein of the immunoglobulin superfamily that is often overexpressed in different types of hematological and solid cancer tumors and plays important role in blocking phagocytosis, increased tumor survival, metastasis and angiogenesis. In the present report, we designed CAR (chimeric antigen receptor)-T cells that bind CD47 antigen. We used ScFv (single chain variable fragment) from mouse CD47 antibody to generate CD47-CAR-T cells for targeting different cancer cell lines. CD47...

  4. Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression

    Directory of Open Access Journals (Sweden)

    Peter F Rebeiro

    2016-04-01

    Full Text Available Introduction: We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART use and viral suppression (VS. Methods: Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care. Results: Among 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each. Female sex (risk ratio (RR=0.97 vs. males and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96 significantly decreased the probability of cART compared with heterosexual transmission. Conclusions: HIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings.

  5. Assessing the HIV Care Continuum in Latin America: progress in clinical retention, cART use and viral suppression

    Science.gov (United States)

    Rebeiro, Peter F; Cesar, Carina; Shepherd, Bryan E; De Boni, Raquel B; Cortés, Claudia P; Rodriguez, Fernanda; Belaunzarán-Zamudio, Pablo; Pape, Jean W; Padgett, Denis; Hoces, Daniel; McGowan, Catherine C; Cahn, Pedro

    2016-01-01

    Introduction We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART) use and viral suppression (VS). Methods Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven countries contributed data between 2003 and 2012. Retention was defined as two or more HIV care visits annually, >90 days apart. cART was defined as prescription of three or more antiretroviral agents annually. VS was defined as HIV-1 RNA <200 copies/mL at last measurement annually. cART and VS denominators were subjects with at least one visit annually. Multivariable modified Poisson regression was used to assess temporal trends and examine associations between age, sex, HIV transmission mode, cohort, calendar year and time in care. Results Among 18,799 individuals in retention analyses, 14,380 in cART analyses and 13,330 in VS analyses, differences existed between those meeting indicator definitions versus those not by most characteristics. Retention, cART and VS significantly improved from 2003 to 2012 (63 to 77%, 74 to 91% and 53 to 82%, respectively; p<0.05, each). Female sex (risk ratio (RR)=0.97 vs. males) and injection drug use as HIV transmission mode (RR=0.83 vs. male sexual contact with males (MSM)) were significantly associated with lower retention, but unrelated with cART or VS. MSM (RR=0.96) significantly decreased the probability of cART compared with heterosexual transmission. Conclusions HIV Care Continuum outcomes improved over time in Latin America, though disparities for vulnerable groups remain. Efforts must be made to increase retention, cART and VS, while engaging in additional research to sustain progress in these settings. PMID:27065108

  6. Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND

    OpenAIRE

    Sanchez, Ana B.; Marcus Kaul

    2017-01-01

    Multiple mechanisms appear to contribute to neuronal stress and injury underlying HIV-associated neurocognitive disorders (HAND), which occur despite the successful introduction of combination antiretroviral therapy (cART). Evidence is accumulating that components of cART can itself be neurotoxic upon long-term exposure. In addition, abuse of psychostimulants, such as methamphetamine (METH), seems to compromise antiretroviral therapy and aggravate HAND. However, the combined effect of virus a...

  7. Development of prognostic indicators using Classification And Regression Trees (CART) for survival

    Science.gov (United States)

    Nunn, Martha E.; Fan, Juanjuan; Su, Xiaogang; McGuire, Michael K.

    2014-01-01

    The development of an accurate prognosis is an integral component of treatment planning in the practice of periodontics. Prior work has evaluated the validity of using various clinical measured parameters for assigning periodontal prognosis as well as for predicting tooth survival and change in clinical conditions over time. We critically review the application of multivariate Classification And Regression Trees (CART) for survival in developing evidence-based periodontal prognostic indicators. We focus attention on two distinct methods of multivariate CART for survival: the marginal goodness-of-fit approach, and the multivariate exponential approach. A number of common clinical measures have been found to be significantly associated with tooth loss from periodontal disease, including furcation involvement, probing depth, mobility, crown-to-root ratio, and oral hygiene. However, the inter-relationships among these measures, as well as the relevance of other clinical measures to tooth loss from periodontal disease (such as bruxism, family history of periodontal disease, and overall bone loss), remain less clear. While inferences drawn from any single current study are necessarily limited, the application of new approaches in epidemiologic analyses to periodontal prognosis, such as CART for survival, should yield important insights into our understanding, and treatment, of periodontal diseases. PMID:22133372

  8. Prediksi Kerawanan Wilayah Terhadap Tindak Pencurian Sepeda Motor Menggunakan Metode (SARIMA Dan CART

    Directory of Open Access Journals (Sweden)

    Pradita Eko Prasetyo Utomo

    2017-07-01

    Full Text Available Motor vehicle theft is a crime that is most common in Indonesia. Growth of vehicle motorcycle significant in each year accompanied by the increasing theft of motorcycles in each year, we need a system that is able to forecast the development and the theft of the motorcycle. This research proposes the development of forecasting models vulnerability criminal offense of theft of motorcycles with ARIMA forecasting method. This method not only forecast from variable of theft but also residents, vehicles and unemployment. The study also determined the classification level of vulnerability to the crime of theft of a motorcycle using a method based on the Decision Tree CART ARIMA forecasting method. Forecasting time series data with ARIMA method performed by each of the variables to produce the best ARIMA forecasting model which varies based on the data pattern of each of those variables. The results of classification by CART method to get the value of accuracy of 92% for the city of Yogyakarta and 85% for DIY. Based on the above, the results of ARIMA forecasting and classification CART can be used in determining the level of vulnerability to the crime of theft of motorcycles.

  9. Automated Cart with VIS/NIR Hyperspectral Reflectance and Fluorescence Imaging Capabilities

    Directory of Open Access Journals (Sweden)

    Alan M. Lefcourt

    2016-12-01

    Full Text Available A system to take high-resolution Visible/Near Infra-Red (VIS/NIR hyperspectral reflectance and fluorescence images in outdoor fields using ambient lighting or a pulsed laser (355 nm, respectively, for illumination purposes was designed, built, and tested. Components of the system include a semi-autonomous cart, a gated-intensified camera, a spectral adapter, a frequency-triple Nd:YAG (Neodymium-doped Yttrium Aluminium Garnet laser, and optics to convert the Gaussian laser beam into a line-illumination source. The front wheels of the cart are independently powered by stepper motors that support stepping or continuous motion. When stepping, a spreadsheet is used to program parameters of image sets to be acquired at each step. For example, the spreadsheet can be used to set delays before the start of image acquisitions, acquisition times, and laser attenuation. One possible use of this functionality would be to establish acquisition parameters to facilitate the measurement of fluorescence decay-curve characteristics. The laser and camera are mounted on an aluminum plate that allows the optics to be calibrated in a laboratory setting and then moved to the cart. The system was validated by acquiring images of fluorescence responses of spinach leaves and dairy manure.

  10. An application of CART algorithm in genetics: IGFs and cGH polymorphisms in Japanese quail

    Science.gov (United States)

    Kaplan, Selçuk

    2017-04-01

    The avian insulin-like growth factor-1 (IGFs) and avian growth hormone (cGH) genes are the most important genes that can affect bird performance traits because of its important function in growth and metabolism. Understanding the molecular genetic basis of variation in growth-related traits is of importance for continued improvement and increased rates of genetic gain. The objective of the present study was to identify polymorphisms of cGH and IGFs genes in Japanese quail using conventional least square method (LSM) and CART algorithm. Therefore, this study was aimed to demonstrate at determining the polymorphisms of two genes related growth characteristics via CART algorithm. A simulated data set was generated to analyze by adhering the results of some poultry genetic studies which it includes live weights at 5 weeks of age, 3 alleles and 6 genotypes of cGH and 2 alleles and 3 genotypes of IGFs. As a result, it has been determined that the CART algorithm has some advantages as for that LSM.

  11. Using CART to Identify Thresholds and Hierarchies in the Determinants of Funding Decisions.

    Science.gov (United States)

    Schilling, Chris; Mortimer, Duncan; Dalziel, Kim

    2017-02-01

    There is much interest in understanding decision-making processes that determine funding outcomes for health interventions. We use classification and regression trees (CART) to identify cost-effectiveness thresholds and hierarchies in the determinants of funding decisions. The hierarchical structure of CART is suited to analyzing complex conditional and nonlinear relationships. Our analysis uncovered hierarchies where interventions were grouped according to their type and objective. Cost-effectiveness thresholds varied markedly depending on which group the intervention belonged to: lifestyle-type interventions with a prevention objective had an incremental cost-effectiveness threshold of $2356, suggesting that such interventions need to be close to cost saving or dominant to be funded. For lifestyle-type interventions with a treatment objective, the threshold was much higher at $37,024. Lower down the tree, intervention attributes such as the level of patient contribution and the eligibility for government reimbursement influenced the likelihood of funding within groups of similar interventions. Comparison between our CART models and previously published results demonstrated concurrence with standard regression techniques while providing additional insights regarding the role of the funding environment and the structure of decision-maker preferences.

  12. Application of CART3D to Complex Propulsion-Airframe Integration with Vehicle Sketch Pad

    Science.gov (United States)

    Hahn, Andrew S.

    2012-01-01

    Vehicle Sketch Pad (VSP) is an easy-to-use modeler used to generate aircraft geometries for use in conceptual design and analysis. It has been used in the past to generate metageometries for aerodynamic analyses ranging from handbook methods to Navier-Stokes computational fluid dynamics (CFD). As desirable as it is to bring high order analyses, such as CFD, into the conceptual design process, this has been difficult and time consuming in practice due to the manual nature of both surface and volume grid generation. Over the last couple of years, VSP has had a major upgrade of its surface triangulation and export capability. This has enhanced its ability to work with Cart3D, an inviscid, three dimensional fluid flow toolset. The combination of VSP and Cart3D allows performing inviscid CFD on complex geometries with relatively high productivity. This paper will illustrate the use of VSP with Cart3D through an example case of a complex propulsion-airframe integration (PAI) of an over-wing nacelle (OWN) airliner configuration.

  13. A Novel Biped Pattern Generator Based on Extended ZMP and Extended Cart-Table Model

    Directory of Open Access Journals (Sweden)

    Guangbin Sun

    2015-07-01

    Full Text Available This paper focuses on planning patterns for biped walking on complex terrains. Two problems are solved: ZMP (zero moment point cannot be used on uneven terrain, and the conventional cart-table model does not allow vertical CM (centre of mass motion. For the ZMP definition problem, we propose the extended ZMP (EZMP concept as an extension of ZMP to uneven terrains. It can be used to judge dynamic balance on universal terrains. We achieve a deeper insight into the connection and difference between ZMP and EZMP by adding different constraints. For the model problem, we extend the cart-table model by using a dynamic constraint instead of constant height constraint, which results in a mathematically symmetric set of three equations. In this way, the vertical motion is enabled and the resultant equations are still linear. Based on the extended ZMP concept and extended cart-table model, a biped pattern generator using triple preview controllers is constructed and implemented simultaneously to three dimensions. Using the proposed pattern generator, the Atlas robot is simulated. The simulation results show the robot can walk stably on rather complex terrains by accurately tracking extended ZMP.

  14. Echocardiographic measurement of cart horses in the metropolitan region of Curitiba-PR

    Directory of Open Access Journals (Sweden)

    Amália Turner Giannico

    2015-04-01

    Full Text Available In order to maintain the horses’ performance during the exercise, their hearts adapt to the variations on metabolic activity, resulting in muscular adaptation. Thus, echocardiography allows to assess on both eventual adaptations of heart tissue and impairment of the ability to pump blood. Little is yet known about echocardiography in cart horses, whose general conditions of health and treatment are often inappropriate to the type of exercise they are submitted to. The goal of this study was to establish echocardiographic numbers for cart horses. Nineteen mongrel horses were submitted for echocardiographic examination, and values of the distance from E point (maximum opening mitral valve to the interventricular septum; diameter of left ventricle cavity, interventricular septum thickness and thickness of left ventricle free wall during systole and diastole, fractional shortening and ejection fraction were obtained by M-mode. In the 2D images, diameter of the aortic valve and left atrium were evaluated, and their relationship. The velocities of the blood flow were evaluated in aorta and pulmonary artery and the mitral valve by means of Doppler, and possible insufficiency was detected through the color Doppler. Mean values for echocardiographic parameters were established considering 19 traction horses that worked pulling cart loads. There were no significant values that indicated either an inappropriate cardiac remodeling, a left ventricular dysfunction – with consequent decrease in exercises performance – or diseases that affect the animal’s performance at work.

  15. The Development of a Smart Distribution Grid Testbed for Integrated Information Management Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Ning; Du, Pengwei; Paulson, Patrick R.; Greitzer, Frank L.; Guo, Xinxin; Hadley, Mark D.

    2011-07-28

    This paper presents a smart distribution grid testbed to test or compare designs of integrated information management systems (I2MSs). An I2MS extracts and synthesizes information from a wide range of data sources to detect abnormal system behaviors, identify possible causes, assess the system status, and provide grid operators with response suggestions. The objective of the testbed is to provide a modeling environment with sufficient data sources for the I2MS design. The testbed includes five information layers and a physical layer; it generates multi-layer chronological data based on actual measurement playbacks or simulated data sets produced by the physical layer. The testbed models random hardware failures, human errors, extreme weather events, and deliberate tampering attempts to allow users to evaluate the performance of different I2MS designs. Initial results of I2MS performance tests showed that the testbed created a close-to-real-world environment that allowed key performance metrics of the I2MS to be evaluated.

  16. The Development of a Smart Distribution Grid Testbed for Integrated Information Management Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Ning; Du, Pengwei; Paulson, Patrick R.; Greitzer, Frank L.; Guo, Xinxin; Hadley, Mark D.

    2011-01-31

    This paper presents a smart distribution grid testbed to test or compare designs of integrated information management systems (I2MSs). An I2MS extracts and synthesizes information from a wide range of data sources to detect abnormal system behaviors, identify possible causes, assess the system status, and provide grid operators with response suggestions. The objective of the testbed is to provide a modeling environment with sufficient data sources for the I2MS design. The testbed includes five information layers and a physical layer; it generates multi-layer chronological data based on actual measurement playbacks or simulated data sets produced by the physical layer. The testbed models random hardware failures, human errors, extreme weather events, and deliberate tampering attempts to allow users to evaluate the performance of different I2MS designs. Initial results of I2MS performance tests showed that the testbed created a close-to-real-world environment that allowed key performance metrics of the I2MS to be evaluated

  17. Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies

    Directory of Open Access Journals (Sweden)

    Jun Liu

    2017-01-01

    Full Text Available Abstract Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT is considered the cornerstone in treatment of hematological malignancies. However, relapse of the hematological disease after allo-HSCT remains a challenge and is associated with poor long-term survival. Chimeric antigen receptor redirected T cells (CAR-T cells can lead to disease remission in patients with relapsed/refractory hematological malignancies. However, the therapeutic window for infusion of CAR-T cells post allo-HSCT and its efficacy are debatable. Main body In this review, we first discuss the use of CAR-T cells for relapsed cases after allo-HSCT. We then review the toxicities and the occurrence of graft-versus-host disease in relapsed patients who received CAR-T cells post allo-HSCT. Finally, we review clinical trial registrations and the therapeutic time window for infusion of CAR-T cells post allo-HSCT. Conclusions The treatment of allogeneic CAR-T cells is beneficial for patients with relapsed B cell malignancies after allo-HSCT with low toxicities and complications. However, multicenter clinical trials with larger sample sizes should be performed to select the optimal therapeutic window and confirm its efficacy.

  18. Fault detection and diagnosis of induction motors using motor current signature analysis and a hybrid FMM-CART model.

    Science.gov (United States)

    Seera, Manjeevan; Lim, Chee Peng; Ishak, Dahaman; Singh, Harapajan

    2012-01-01

    In this paper, a novel approach to detect and classify comprehensive fault conditions of induction motors using a hybrid fuzzy min-max (FMM) neural network and classification and regression tree (CART) is proposed. The hybrid model, known as FMM-CART, exploits the advantages of both FMM and CART for undertaking data classification and rule extraction problems. A series of real experiments is conducted, whereby the motor current signature analysis method is applied to form a database comprising stator current signatures under different motor conditions. The signal harmonics from the power spectral density are extracted as discriminative input features for fault detection and classification with FMM-CART. A comprehensive list of induction motor fault conditions, viz., broken rotor bars, unbalanced voltages, stator winding faults, and eccentricity problems, has been successfully classified using FMM-CART with good accuracy rates. The results are comparable, if not better, than those reported in the literature. Useful explanatory rules in the form of a decision tree are also elicited from FMM-CART to analyze and understand different fault conditions of induction motors.

  19. Nursing perception of the impact of medication carts on patient safety and ergonomics in a teaching health care center.

    Science.gov (United States)

    Rochais, Élise; Atkinson, Suzanne; Bussières, Jean-François

    2013-04-01

    In our Quebec (Canada) University Hospital Center, 68 medication carts have been implemented as part of a nationally funded project on drug distribution technologies. There are limited data published about the impact of medication carts in point-of-care units. Our main objective was to assess nursing staff's perception and satisfaction of medication carts on patient safety and ergonomics. Quantitative and qualitative cross-sectional study. Data were gathered from a printed questionnaire administered to nurses and an organized focus group composed of nurses and pharmacists. A total of 195 nurses completed the questionnaire. Eighty percent of the nurses agreed that medication carts made health care staff's work easier and 64% agreed that it helped to reduce medication incidents/accidents. Only 27% and 43% agreed that carts' location reduces the risk of patients' interruptions and colleagues' interruptions, respectively. A total of 17 suggestions were extracted from the focus group (n = 7 nurses; n = 3 pharmacist) and will be implemented in the next year. This descriptive study confirms the positive perception and satisfaction of nurses exposed to medication carts. However, interruptions are a major concern and source of dissatisfaction. The focus group has revealed many issues which will be improved.

  20. Combination antiretroviral therapy (cART) restores HIV-1 infection-mediated impairment of JAK-STAT signaling pathway.

    Science.gov (United States)

    Liu, Man-Qing; Zhao, Min; Kong, Wen-Hua; Tang, Li; Wang, Fang; Zhu, Ze-Rong; Wang, Xia; Qiu, Hong-Yan; Zhou, Dun-Jin; Wang, Xu; Ho, Wen-Zhe; Zhou, Wang

    2017-04-04

    JAK-STAT signaling pathway has a crucial role in host innate immunity against viral infections, including HIV-1. We therefore examined the impact of HIV-1 infection and combination antiretroviral therapy (cART) on JAK-STAT signaling pathway. Compared to age-matched healthy donors (n = 18), HIV-1-infected subjects (n = 18) prior to cART had significantly lower expression of toll-like receptors (TLR-1/4/6/7/8/9), the IFN regulatory factors (IRF-3/7/9), and the antiviral factors (OAS-1, MxA, A3G, PKR, and Tetherin). Three months' cART partially restores the impaired functions of JAK-STAT-mediated antiviral immunity. We also found most factors had significantly positive correlations (p HIV-1-infected subjects (43.86%, 75/171), and stably increased during the cART (57.31%, 98/171 after 6 months' cART). With regard to the restoration of some HIV-1 restriction factors, HIV-1-infected subjects who had CD4+ T cell counts > 350//μl responded better to cART than those with the counts HIV-1 disease.

  1. Conceptual Design and Cost Estimate of a Subsonic NASA Testbed Vehicle (NTV) for Aeronautics Research

    Science.gov (United States)

    Nickol, Craig L.; Frederic, Peter

    2013-01-01

    A conceptual design and cost estimate for a subsonic flight research vehicle designed to support NASA's Environmentally Responsible Aviation (ERA) project goals is presented. To investigate the technical and economic feasibility of modifying an existing aircraft, a highly modified Boeing 717 was developed for maturation of technologies supporting the three ERA project goals of reduced fuel burn, noise, and emissions. This modified 717 utilizes midfuselage mounted modern high bypass ratio engines in conjunction with engine exhaust shielding structures to provide a low noise testbed. The testbed also integrates a natural laminar flow wing section and active flow control for the vertical tail. An eight year program plan was created to incrementally modify and test the vehicle, enabling the suite of technology benefits to be isolated and quantified. Based on the conceptual design and programmatic plan for this testbed vehicle, a full cost estimate of $526M was developed, representing then-year dollars at a 50% confidence level.

  2. Model-based beam control for illumination of remote objects, part II: laboratory testbed

    Science.gov (United States)

    Basu, Santasri; Voelz, David; Chandler, Susan M.; Lukesh, Gordon W.; Sjogren, Jon

    2004-10-01

    When a laser beam propagates through the atmosphere, it is subject to corrupting influences including mechanical vibrations, turbulence and tracker limitations. As a result, pointing errors can occur, causing loss of energy or signal at the target. Nukove Scientific Consulting has developed algorithms to estimate these pointing errors from the statistics of the return photons from the target. To prove the feasibility of this approach for real-time estimation, an analysis tool called RHINO was developed by Nukove. Associated with this effort, New Mexico State University developed a laboratory testbed, the ultimate objective being to test the estimation algorithms under controlled conditions and to stream data into RHINO to prove the feasibility of real-time operation. The present paper outlines the description of this testbed and the results obtained through RHINO when the testbed was used to test the estimation approach.

  3. Comparison of two matrix data structures for advanced CSM testbed applications

    Science.gov (United States)

    Regelbrugge, M. E.; Brogan, F. A.; Nour-Omid, B.; Rankin, C. C.; Wright, M. A.

    1989-01-01

    The first section describes data storage schemes presently used by the Computational Structural Mechanics (CSM) testbed sparse matrix facilities and similar skyline (profile) matrix facilities. The second section contains a discussion of certain features required for the implementation of particular advanced CSM algorithms, and how these features might be incorporated into the data storage schemes described previously. The third section presents recommendations, based on the discussions of the prior sections, for directing future CSM testbed development to provide necessary matrix facilities for advanced algorithm implementation and use. The objective is to lend insight into the matrix structures discussed and to help explain the process of evaluating alternative matrix data structures and utilities for subsequent use in the CSM testbed.

  4. Effect of site characteristics on the productivity and economic returns ...

    African Journals Online (AJOL)

    EJIRO

    stripped treatment. Root yield of cassava cowpea mixed intercrop for example ranged from 38 to 88 t/ha. In the second year however, considerable variations were observed among the treatments with ... plete the soil of its nutrients and diminish the economics ... carting of manure to farm site, labour for application also.

  5. Implementation of a Wireless Time Distribution Testbed Protected with Quantum Key Distribution

    Energy Technology Data Exchange (ETDEWEB)

    Bonior, Jason D [ORNL; Evans, Philip G [ORNL; Sheets, Gregory S [ORNL; Jones, John P [ORNL; Flynn, Toby H [ORNL; O' Neil, Lori Ross [Pacific Northwest National Laboratory (PNNL); Hutton, William [Pacific Northwest National Laboratory (PNNL); Pratt, Richard [Pacific Northwest National Laboratory (PNNL); Carroll, Thomas E. [Pacific Northwest National Laboratory (PNNL)

    2017-01-01

    Secure time transfer is critical for many timesensitive applications. the Global Positioning System (GPS) which is often used for this purpose has been shown to be susceptible to spoofing attacks. Quantum Key Distribution offers a way to securely generate encryption keys at two locations. Through careful use of this information it is possible to create a system that is more resistant to spoofing attacks. In this paper we describe our work to create a testbed which utilizes QKD and traditional RF links. This testbed will be used for the development of more secure and spoofing resistant time distribution protocols.

  6. A spectral phase encoded time spreading optical code division multiple access testbed

    Science.gov (United States)

    Cong, Wei

    Spectral phase-encode time-spreading (SPECTS) is a promising technique for optical code-division multiple-access (O-CDMA) networks. In SPECTS O-CDMA, users are multiplexed and distinguished with unique phase codes impressed on the spectrum of ultra-short optical signal pulses. The encoding and decoding processes are implemented with grating/lens zero-dispersion pulse-shapers using spatial light phase modulators (SLPMs) in the Fourier plane. The SLPMs add the encoding or decoding O-CDMA phase codes on the spectrum which is spatially spread and then recombined by the grating(s) and lens(es). In this dissertation, we demonstrate a SPECTS O-CDMA network testbed with large throughputs and high performances. Two types of fiber-pigtailed bulk-optic pulseshapers, 1-D transparent-mode and 2-D reflective-mode, are constructed to be used as SPECTS O-CDMA encoders and decoders in the testbed. In order to support a large number of users, the testbed includes up to eight SPECTS O-CDMA encoding channels and one decoding channel. With the combination of time-slotting and polarization-multiplexing operations, the maximum throughput achieved on the testbed is 32 users (8 O-CDMA channel x 2 time slots x 2 polarizations) at 10 Gb/s/user. Two nonlinear detecting techniques (thresholding and gating) for coherent SPECTS O-CDMA are discussed in the dissertation. A nonlinear thresholder and a nonlinear optical loop mirror (NOLM) time gate are built in the testbed; each uses a 500-m highly nonlinear fiber(HNLF). An "O-CDMA receiver" including the NOLM and the thresholder followed by an optical-electrical (O-E) converter can distinguish the intended user by demultiplexing the time-slotted signal and then suppressing the multi-user interference (MUI). In the bit-error-rate (BER) statistics experiments, the "O-CDMA receiver" can detect the intended user's signal with error-free or low BER performance in various testbed structures. Network-layer application experiments including video

  7. Virtual Pipeline System Testbed to Optimize the U.S. Natural Gas Transmission Pipeline System

    Energy Technology Data Exchange (ETDEWEB)

    Kirby S. Chapman; Prakash Krishniswami; Virg Wallentine; Mohammed Abbaspour; Revathi Ranganathan; Ravi Addanki; Jeet Sengupta; Liubo Chen

    2005-06-01

    The goal of this project is to develop a Virtual Pipeline System Testbed (VPST) for natural gas transmission. This study uses a fully implicit finite difference method to analyze transient, nonisothermal compressible gas flow through a gas pipeline system. The inertia term of the momentum equation is included in the analysis. The testbed simulate compressor stations, the pipe that connects these compressor stations, the supply sources, and the end-user demand markets. The compressor station is described by identifying the make, model, and number of engines, gas turbines, and compressors. System operators and engineers can analyze the impact of system changes on the dynamic deliverability of gas and on the environment.

  8. Software architecture design for a dynamic spectrum allocation-enabled cognitive radio testbed

    DEFF Research Database (Denmark)

    Tonelli, Oscar; Berardinelli, Gilberto; Cattoni, Andrea Fabio

    2011-01-01

    The evolution of wireless communications is bringing into reality the dense deployment of femto and local area cells, which represents a challenging scenario for proving the effectiveness of Cognitive Radio (CR) frameworks. In particular the Dynamic Spectrum Allocation (DSA) paradigm aims...... for the definition of a CR-based, local area-oriented testbed platform is introduced. In particular, the testbed design in relation to the selected scenario and the architecture of the developed software framework are presented. An analysis of the performance of key software functionalities is also provided...

  9. Towards Autonomous Operations of the Robonaut 2 Humanoid Robotic Testbed

    Science.gov (United States)

    Badger, Julia; Nguyen, Vienny; Mehling, Joshua; Hambuchen, Kimberly; Diftler, Myron; Luna, Ryan; Baker, William; Joyce, Charles

    2016-01-01

    The Robonaut project has been conducting research in robotics technology on board the International Space Station (ISS) since 2012. Recently, the original upper body humanoid robot was upgraded by the addition of two climbing manipulators ("legs"), more capable processors, and new sensors, as shown in Figure 1. While Robonaut 2 (R2) has been working through checkout exercises on orbit following the upgrade, technology development on the ground has continued to advance. Through the Active Reduced Gravity Offload System (ARGOS), the Robonaut team has been able to develop technologies that will enable full operation of the robotic testbed on orbit using similar robots located at the Johnson Space Center. Once these technologies have been vetted in this way, they will be implemented and tested on the R2 unit on board the ISS. The goal of this work is to create a fully-featured robotics research platform on board the ISS to increase the technology readiness level of technologies that will aid in future exploration missions. Technology development has thus far followed two main paths, autonomous climbing and efficient tool manipulation. Central to both technologies has been the incorporation of a human robotic interaction paradigm that involves the visualization of sensory and pre-planned command data with models of the robot and its environment. Figure 2 shows screenshots of these interactive tools, built in rviz, that are used to develop and implement these technologies on R2. Robonaut 2 is designed to move along the handrails and seat track around the US lab inside the ISS. This is difficult for many reasons, namely the environment is cluttered and constrained, the robot has many degrees of freedom (DOF) it can utilize for climbing, and remote commanding for precision tasks such as grasping handrails is time-consuming and difficult. Because of this, it is important to develop the technologies needed to allow the robot to reach operator-specified positions as

  10. Integration of stress and leptin signaling by CART producing neurons in the rodent midbrain centrally projecting Edinger-Westphal nucleus

    Directory of Open Access Journals (Sweden)

    Lu eXu

    2014-03-01

    Full Text Available Leptin targets the brain to regulate feeding, neuroendocrine function and metabolism. The leptin receptor is present in hypothalamic centers controlling energy metabolism as well as in the centrally projecting Edinger-Westphal nucleus (EWcp, a region implicated in the stress response and in various aspects of stress-related behaviors. We hypothesized that the stress response by cocaine- and amphetamine-regulated transcript (CART-producing EWcp-neurons would depend on the animal’s energy state. To test this hypothesis, we investigated the effects of changes in energy state (mimicked by low, normal and high leptin levels, which were achieved by 24h fasting, normal chow and leptin injection, respectively on the response of CART neurons in the EWcp of rats subjected or not to acute restraint stress. Our data show that leptin treatment alone significantly increases CART mRNA expression in the rat EWcp and that in leptin receptor deficient (db/db mice, the number of CART producing neurons in this nucleus is reduced. This suggests that leptin has a stimulatory effect on the production of CART in the EWcp under non-stressed condition. Under stressed condition, however, leptin blunts stress-induced activation of EWcp neurons and decreases their CART mRNA expression. Interestingly, fasting, does not influence the stress-induced activation of EWcp-neurons, and specifically EWcp-CART neurons are not activated. These results suggest that the stress response by the EWcp depends to some degree on the animal’s energy state, a mechanism that may contribute to a better understanding of the complex interplay between obesity and stress.

  11. Integration of stress and leptin signaling by CART producing neurons in the rodent midbrain centrally projecting Edinger-Westphal nucleus.

    Science.gov (United States)

    Xu, Lu; Janssen, Donny; van der Knaap, Noortje; Roubos, Eric W; Leshan, Rebecca L; Myers, Martin G; Gaszner, Balázs; Kozicz, Tamás

    2014-01-01

    Leptin targets the brain to regulate feeding, neuroendocrine function and metabolism. The leptin receptor is present in hypothalamic centers controlling energy metabolism as well as in the centrally projecting Edinger-Westphal nucleus (EWcp), a region implicated in the stress response and in various aspects of stress-related behaviors. We hypothesized that the stress response by cocaine- and amphetamine-regulated transcript (CART)-producing EWcp-neurons would depend on the animal's energy state. To test this hypothesis, we investigated the effects of changes in energy state (mimicked by low, normal and high leptin levels, which were achieved by 24 h fasting, normal chow and leptin injection, respectively) on the response of CART neurons in the EWcp of rats subjected or not to acute restraint stress. Our data show that leptin treatment alone significantly increases CART mRNA expression in the rat EWcp and that in leptin receptor deficient (db/db) mice, the number of CART producing neurons in this nucleus is reduced. This suggests that leptin has a stimulatory effect on the production of CART in the EWcp under non-stressed condition. Under stressed condition, however, leptin blunts stress-induced activation of EWcp neurons and decreases their CART mRNA expression. Interestingly, fasting, does not influence the stress-induced activation of EWcp-neurons, and specifically EWcp-CART neurons are not activated. These results suggest that the stress response by the EWcp depends to some degree on the animal's energy state, a mechanism that may contribute to a better understanding of the complex interplay between obesity and stress.

  12. Nodal Solutions of the SP{sub N} Transport Equation for the DeCART Code

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Joo, H. G

    2007-06-15

    This report discusses how to improve the axial solution of the DeCART code and how to introduce the transport solution effectively. This report includes: (1) The conventional solution using radial CMFD and axial NEM kernel for the diffusion approximation and its extension to the SPN transport equation. (2) The axial SANM kernel for the diffusion approximation within the conventional CMFD framework. This work is performed for the future application of the SANM solution to the SPN approximation (3) The axial lower order polynomial expansion nodal (LPEN) kernel for the diffusion and the SP3 transport equations. This work is performed to reduce the memory requirement and to remove the transverse leakage effect. (4) A new transverse leakage approximation using intra-nodal flux distribution to improve NEM and SANM solution accuracy. (5) Sub-plane scheme to obtain the DeCART solutions efficiently. (6) Radial MOC solution without the transverse leakage and its application to obtain the equivalent parameters. This work is performed to eliminate the negative scalar flux and finally to remove convergence problem of the DeCART code. (7) Examination of the DeCART solution for a demonstrative problem and the C5G7MOX 3-D Extension problems. The results of the examination can be summarized as: (1) The SANM solution with a new transverse leakage approximation shows a very good accuracy when comparing with the NEM solution. (2) Introduction of the sub-plane scheme eliminates most of the nodal error with a little bit increased computational burden. (3) Introduction of the NEM solution for the SP3 transport equation eliminate most of the diffusion effect. (4) NEM solution for the SP3 transport equation by using a few sub-planes and a new transverse leakage approximation produces a compatible solution with the MCNP code. (5) LPEN kernel requires about 3 times more sub-planes than the NEM or SANM kernels to remove the nodal errors. However, this method requires less computational memory

  13. Propositions méthodologiques pour l’amélioration automatique des contrastes de couleur - application aux cartes de risque

    Directory of Open Access Journals (Sweden)

    Elisabeth Chesneau

    2006-11-01

    Full Text Available Les cartes peuvent contenir de nombreuses informations qui souvent se chevauchent, ce qui rend les données difficiles à cartographier. Nous pensons qu’une meilleure utilisation de la couleur dans ces cartes peut en améliorer la lisibilité. C’est pourquoi, en nous appuyant sur les contrastes de couleur définis par J. Itten, graphiste et peintre suisse du 20ème siècle, nous proposons de développer un modèle qui améliore les contrastes colorés dans les cartes, en particulier les cartes de risque.

  14. Salmonella collected from nest run cart shelves in commercial shell egg processing facilities.

    Science.gov (United States)

    Musgrove, M T; Shaw, J D; Harrison, M A

    2012-09-01

    Salmonella, a member of the bacterial family Enterobacteriaceae, may be recovered from foods and processing facilities. High levels of Enterobacteriaceae in the processing plant environment can be an indication of inadequate sanitation. This experiment was designed to determine if nest run egg carts serve as reservoirs for Salmonella. Eggs that are produced by hens not housed in buildings connected to the processing plant are referred to as nest run. Many of these eggs are transported to a central processing facility before they are washed, graded, and packed. Two plants in the Southeastern United States were sampled; one was a mixed operation and the other was an off-line operation. On each of 3 visits, 5 shelves on each of 5 carts were sampled (n = 25/visit). A 12 × 12 cm area on each shelf was swabbed with a sterile gauze pad moistened with PBS and transported on ice back to the laboratory. Each swab was preenriched in buffered peptone at 37°C for 24 h, selectively enriched using TT and Rappaport-Vassiliadis broth at 42°C overnight, then plated onto brilliant green sulfa and XLT-4 incubated at 37°C for 24 h. Presumptive colonies were transferred to lysine iron agar and triple sugar iron slants for 24 h at 37°C. Isolates with presumptive reactions were confirmed using commercial polyclonal antisera. After initial confirmation, serogrouping was performed using commercial antisera. Mixed-operation swab samples were 12% positive for Salmonella, whereas off-line samples were 36% positive for Salmonella; isolates were confirmed as serogroups B, C1, and C2. Kauffman-White serotyping was performed by a contract laboratory. Serotypes (n = 30) recovered were Anatum, Heidelberg, Infantis, Kentucky, Mbandanka, and Typhimurium. This work demonstrated that nest run egg carts may serve as reservoirs for Salmonella in the shell egg processing environment.

  15. Ensayo de resistencia a la compresión de cartón ondulado

    OpenAIRE

    García Bol, Ana María

    2013-01-01

    Por medio de este trabajo se puede observar la importancia de un sistema de calidad en la empresa. Los ensayos de ECT realizados en el laboratorio pretenden cumplir los requisitos propios y del cliente, siendo esto básico y asociado al concepto de calidad, no sólo en la industria del cartón ondulado sino en todas las restantes. Hemos visto todo el proceso productivo, ensayos, resultados mediante control estadístico, además de realizar ensayos de gramaje, comentar la trazabilidad y la política...

  16. Loading of carts in barges at HHM, Shanghai, beginning December 2000.

    CERN Multimedia

    F. Feyzi

    2000-01-01

    End of manufacture of encap carts at HHM in Shanghai. HHM has done an excellent job in manufacturing these parts with high quality and on time. HHM Vice General Manager Mr. Zhao Cheng Xiang hosted an excellent farewell dinner for F. Feyzi and J. Wollert on December 1 where all colleagues from HHM who have worked with us over the past two years were present. Each person played a key role in the success of the project and F. Feyzi thanked them individually on behalf of CMS.

  17. Putting the horse before the cart: a pragmatist analysis of knowledge

    Directory of Open Access Journals (Sweden)

    Luís M. Augusto

    2011-01-01

    Full Text Available The definition of knowledge as justified true belief is the best we presently have. However, the canonical tripartite analysis of knowledge does not do justice to it due to a Platonic conception of a priori truth that puts the cart before the horse. Within a pragmatic approach, I argue that by doing away with a priori truth, namely by submitting truth to justification, and by accordingly altering the canonical analysis of knowledge, this is a fruitful definition. So fruitful indeed that it renders the Gettier counterexamples vacuous, allowing positive work in epistemology and related disciplines.

  18. Substance use and adherence among people living with HIV/AIDS receiving cART in Latin America

    Science.gov (United States)

    De Boni, Raquel B.; Shepherd, Bryan E.; Grinsztejn, Beatriz; Cesar, Carina; Cortés, Claudia; Padgett, Denis; Gotuzzo, Eduardo; Belaunzarán-Zamudio, Pablo F.; Rebeiro, Peter F.; Duda, Stephany N.; McGowan, Catherine C.

    2016-01-01

    This cross-sectional study describes substance use prevalence and its association with cART adherence among 3343 individuals receiving care at HIV clinics in Argentina, Brazil, Chile, Honduras, Mexico, and Peru. A rapid screening tool evaluated self-reported 7-day recall of alcohol, marijuana, cocaine, heroin, and methamphetamine use, and missed cART doses. Overall, 29.3% individuals reported having ≥ 1 alcoholic drinks, 5.0% reported any illicit drug use and 17.0% reported missed cART doses. In the logistic regression model, compared to no substance use, alcohol use (adjusted odds ratio (AOR)=2.46, 95% confidence interval (CI): 1.99–3.05), illicit drug use (AOR=3.57, 95% CI: 2.02–6.30), and using both alcohol and illicit drugs (AOR=4.98, 95% CI: 3.19–7.79) were associated with missed cART doses. The associations between substance use and likelihood of missing cART doses point to the need of targeting alcohol and illicit drug use to improve adherence among people living with HIV in Latin America. PMID:27091028

  19. Development and validation of a low-cost mobile robotics testbed

    Science.gov (United States)

    Johnson, Michael; Hayes, Martin

    2012-03-01

    This paper considers the design, construction and validation of a low-cost experimental robotic testbed, which allows for the localisation and tracking of multiple robotic agents in real time. The testbed system is suitable for research and education in a range of different mobile robotic applications, for validating theoretical as well as practical research work in the field of digital control, mobile robotics, graphical programming and video tracking systems. It provides a reconfigurable floor space for mobile robotic agents to operate within, while tracking the position of multiple agents in real-time using the overhead vision system. The overall system provides a highly cost-effective solution to the topical problem of providing students with practical robotics experience within severe budget constraints. Several problems encountered in the design and development of the mobile robotic testbed and associated tracking system, such as radial lens distortion and the selection of robot identifier templates are clearly addressed. The testbed performance is quantified and several experiments involving LEGO Mindstorm NXT and Merlin System MiaBot robots are discussed.

  20. A Matlab-Based Testbed for Integration, Evaluation and Comparison of Heterogeneous Stereo Vision Matching Algorithms

    Directory of Open Access Journals (Sweden)

    Raul Correal

    2016-11-01

    Full Text Available Stereo matching is a heavily researched area with a prolific published literature and a broad spectrum of heterogeneous algorithms available in diverse programming languages. This paper presents a Matlab-based testbed that aims to centralize and standardize this variety of both current and prospective stereo matching approaches. The proposed testbed aims to facilitate the application of stereo-based methods to real situations. It allows for configuring and executing algorithms, as well as comparing results, in a fast, easy and friendly setting. Algorithms can be combined so that a series of processes can be chained and executed consecutively, using the output of a process as input for the next; some additional filtering and image processing techniques have been included within the testbed for this purpose. A use case is included to illustrate how these processes are sequenced and its effect on the results for real applications. The testbed has been conceived as a collaborative and incremental open-source project, where its code is accessible and modifiable, with the objective of receiving contributions and releasing future versions to include new algorithms and features. It is currently available online for the research community.

  1. Validation of Model-Based Prognostics for Pneumatic Valves in a Demonstration Testbed

    Science.gov (United States)

    2014-10-02

    distribution, and reproduction in any medium, pro- vided the original author and source are credited. bile robots (Tang, Hettler , Zhang, & DeCastro, 2011; Bala...in- fotech@aerospace 2007 conference and exhibit. Tang, L., Hettler , E., Zhang, B., & DeCastro, J. (2011). A testbed for real-time autonomous vehicle

  2. Data Distribution Service-Based Interoperability Framework for Smart Grid Testbed Infrastructure

    Directory of Open Access Journals (Sweden)

    Tarek A. Youssef

    2016-03-01

    Full Text Available This paper presents the design and implementation of a communication and control infrastructure for smart grid operation. The proposed infrastructure enhances the reliability of the measurements and control network. The advantages of utilizing the data-centric over message-centric communication approach are discussed in the context of smart grid applications. The data distribution service (DDS is used to implement a data-centric common data bus for the smart grid. This common data bus improves the communication reliability, enabling distributed control and smart load management. These enhancements are achieved by avoiding a single point of failure while enabling peer-to-peer communication and an automatic discovery feature for dynamic participating nodes. The infrastructure and ideas presented in this paper were implemented and tested on the smart grid testbed. A toolbox and application programing interface for the testbed infrastructure are developed in order to facilitate interoperability and remote access to the testbed. This interface allows control, monitoring, and performing of experiments remotely. Furthermore, it could be used to integrate multidisciplinary testbeds to study complex cyber-physical systems (CPS.

  3. Software-Defined Radio Testbed for the Physical Layer of Wireless LANs

    NARCIS (Netherlands)

    Schiphorst, Roelof; Moseley, N.A.; Slump, Cornelis H.

    2005-01-01

    This paper presents a software-defined radio testbed for the physical layer of wireless LAN standards. All baseband physical layer functions have been successfully mapped on a Pentium~4 processor that performs these functions in real-time. This has been tested in combination with a CMOS integrated

  4. Embedded Sensors and Controls to Improve Component Performance and Reliability -- Bench-scale Testbed Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Melin, Alexander M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kisner, Roger A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Drira, Anis [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Reed, Frederick K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    Embedded instrumentation and control systems that can operate in extreme environments are challenging due to restrictions on sensors and materials. As a part of the Department of Energy's Nuclear Energy Enabling Technology cross-cutting technology development programs Advanced Sensors and Instrumentation topic, this report details the design of a bench-scale embedded instrumentation and control testbed. The design goal of the bench-scale testbed is to build a re-configurable system that can rapidly deploy and test advanced control algorithms in a hardware in the loop setup. The bench-scale testbed will be designed as a fluid pump analog that uses active magnetic bearings to support the shaft. The testbed represents an application that would improve the efficiency and performance of high temperature (700 C) pumps for liquid salt reactors that operate in an extreme environment and provide many engineering challenges that can be overcome with embedded instrumentation and control. This report will give details of the mechanical design, electromagnetic design, geometry optimization, power electronics design, and initial control system design.

  5. Human Exploration Spacecraft Testbed for Integration and Advancement (HESTIA)

    Science.gov (United States)

    Banker, Brian F.; Robinson, Travis

    2016-01-01

    The proposed paper will cover ongoing effort named HESTIA (Human Exploration Spacecraft Testbed for Integration and Advancement), led at the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) to promote a cross-subsystem approach to developing Mars-enabling technologies with the ultimate goal of integrated system optimization. HESTIA also aims to develop the infrastructure required to rapidly test these highly integrated systems at a low cost. The initial focus is on the common fluids architecture required to enable human exploration of mars, specifically between life support and in-situ resource utilization (ISRU) subsystems. An overview of the advancements in both integrated technologies, in infrastructure, in simulation, and in modeling capabilities will be presented, as well as the results and findings of integrated testing,. Due to the enormous mass gear-ratio required for human exploration beyond low-earth orbit, (for every 1 kg of payload landed on Mars, 226 kg will be required on Earth), minimization of surface hardware and commodities is paramount. Hardware requirements can be minimized by reduction of equipment performing similar functions though for different subsystems. If hardware could be developed which meets the requirements of both life support and ISRU it could result in the reduction of primary hardware and/or reduction in spares. Minimization of commodities to the surface of mars can be achieved through the creation of higher efficiency systems producing little to no undesired waste, such as a closed-loop life support subsystem. Where complete efficiency is impossible or impractical, makeup commodities could be manufactured via ISRU. Although, utilization of ISRU products (oxygen and water) for crew consumption holds great promise of reducing demands on life support hardware, there exist concerns as to the purity and transportation of commodities. To date, ISRU has been focused on production rates and purities for

  6. Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naïve patients starting cART after January 1, 2000

    DEFF Research Database (Denmark)

    Mocroft, A; Horban, A; Clumeck, N

    2006-01-01

    BACKGROUND: Few published studies have considered both the short- and long-term virologic or immunologic response to combination antiretroviral therapy (cART) and the impact of different cART strategies. PURPOSE: To compare time to initial virologic (200/mm3 cell...... a single-PI-based regimen were more likely to not have virologic suppression (2.40, p = .024), while there were no differences in the odds of having an immunologic response (>200/mm3 increase; p > .15). This model was adjusted for CD4 and VL at starting c...

  7. Comparison of single and boosted protease inhibitor versus nonnucleoside reverse transcriptase inhibitor-containing cART regimens in antiretroviral-naïve patients starting cART after January 1, 2000

    DEFF Research Database (Denmark)

    Mocroft, A; Horban, A; Clumeck, N

    2006-01-01

    increase) response in antiretroviral-naïve patients starting either a single protease inhibitor (PI; n = 183), a ritonavir-boosted PI regimen (n = 197), or a nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART regimen (n = 447) after January 1, 2000, and the odds of lack of virologic...... or immunologic response at 3 years after starting cART. METHOD: Cox proportional hazards models and logistic regression. RESULTS: After adjustment, compared to patients taking an NNRTI-regimen, patients taking a single-PI regimen were significantly less likely to achieve a viral load (VL)

  8. Embedded Sensors and Controls to Improve Component Performance and Reliability -- Loop-scale Testbed Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Melin, Alexander M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kisner, Roger A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-01

    Embedded instrumentation and control systems that can operate in extreme environments are challenging to design and operate. Extreme environments limit the options for sensors and actuators and degrade their performance. Because sensors and actuators are necessary for feedback control, these limitations mean that designing embedded instrumentation and control systems for the challenging environments of nuclear reactors requires advanced technical solutions that are not available commercially. This report details the development of testbed that will be used for cross-cutting embedded instrumentation and control research for nuclear power applications. This research is funded by the Department of Energy's Nuclear Energy Enabling Technology program's Advanced Sensors and Instrumentation topic. The design goal of the loop-scale testbed is to build a low temperature pump that utilizes magnetic bearing that will be incorporated into a water loop to test control system performance and self-sensing techniques. Specifically, this testbed will be used to analyze control system performance in response to nonlinear and cross-coupling fluid effects between the shaft axes of motion, rotordynamics and gyroscopic effects, and impeller disturbances. This testbed will also be used to characterize the performance losses when using self-sensing position measurement techniques. Active magnetic bearings are a technology that can reduce failures and maintenance costs in nuclear power plants. They are particularly relevant to liquid salt reactors that operate at high temperatures (700 C). Pumps used in the extreme environment of liquid salt reactors provide many engineering challenges that can be overcome with magnetic bearings and their associated embedded instrumentation and control. This report will give details of the mechanical design and electromagnetic design of the loop-scale embedded instrumentation and control testbed.

  9. La «crise» dans l’Union européenne vue par les cartes

    Directory of Open Access Journals (Sweden)

    Jean-Paul Bord

    2012-08-01

    Full Text Available Une carte extraite d'un dossier sur la «crise» dans l'Union européenne, parue en 2011 dans le Nouvel Observateur, est critiquée du point de vue de la sémiologie graphique. L'auteur s'interroge sur le choix des pays étudiés ainsi que sur les indicateurs retenus. Des solutions cartographiques plus «utiles» sont ensuite présentées, c'est-à-dire plus facilement compréhensibles et mémorisables, par le biais de constructions mieux adaptées: collection de cartes et cartes de synthèse typologiques avec traitements statistiques (analyse en composantes principales, ACP et graphique (matrice ordonnable Bertin.

  10. The prevalence of lameness and associated risk factors in cart mules in Bahir Dar, Ethiopia.

    Science.gov (United States)

    Ali, Alina; Orion, Solomon; Tesfaye, Tewodros; Zambriski, Jennifer A

    2016-10-01

    Ethiopia has 7.1 million donkeys and mules, the majority of which are used as pack animals. Factors such as poor harness quality, long-distance traveling, and heavy cartloads have been linked to reduced work efficiency. Addressing the health and welfare of working equids is imperative not only for the animals but also for the households dependent upon them for livelihood. In developing countries, 75 % of working equids have gait or limb abnormalities, but the relationship between workload and prevalence of lameness is unknown. We examined 450 cart mules in Bahir Dar, Ethiopia. Lameness and workload were assessed through use of a survey and lameness exam. We found that 26.8 % of cart mules were lame, and acute lameness of the forelimb was the most common. Animals with poor harness quality were 2.5 times more likely to have sores and 1.6 times more likely to be lame. Lameness tended to be associated with cartloads >700 kg (P = 0.09), and there was a significant association between multiple-leg lameness and cartload weight (P = 0.03). The presence of sores was the best predictor of lameness (P = 0.001). Possible areas of intervention may include education to reduce average daily workload and improving harness design.

  11. A comparative study of CART and PTM for modelling water age

    Science.gov (United States)

    Wang, Haiyan; Guo, Xinyu; Liu, Zhe; Gao, Huiwang

    2015-02-01

    CART (Constituent-oriented age and residence time theory) and PTM (Particle-tracking method) are two widely used numerical methods to calculate water age. These two methods are essentially equivalent in theory but their results may be different in practice. The difference of the two methods was evaluated by applying them to calculate water age in an idealized one-dimensional domain. The model results by the two methods are consistent with each other in the case with either spatially uniform flow field or spatially uniform diffusion coefficient. If we allow the spatial variation in horizontal diffusion, a term called pseudo displacement arising from the spatial variation of diffusion coefficient likely plays an important role for the PTM to obtain accurate water age. In particular, if the water particle is released at a place where the diffusion is not the weakest, the water age calculated by the PTM without pseudo displacement is much larger than that by the CART. This suggests that the pseudo displacement cannot be neglected in the PTM to calculate water age in a realistic ocean. As an example, we present its potential importance in the Bohai Sea where the diffusion coefficient varies spatially and greatly.

  12. "New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).

    Science.gov (United States)

    Nelson, Peter T; Trojanowski, John Q; Abner, Erin L; Al-Janabi, Omar M; Jicha, Gregory A; Schmitt, Frederick A; Smith, Charles D; Fardo, David W; Wang, Wang-Xia; Kryscio, Richard J; Neltner, Janna H; Kukull, Walter A; Cykowski, Matthew D; Van Eldik, Linda J; Ighodaro, Eseosa T

    2016-06-01

    The pathology-based classification of Alzheimer's disease (AD) and other neurodegenerative diseases is a work in progress that is important for both clinicians and basic scientists. Analyses of large autopsy series, biomarker studies, and genomics analyses have provided important insights about AD and shed light on previously unrecognized conditions, enabling a deeper understanding of neurodegenerative diseases in general. After demonstrating the importance of correct disease classification for AD and primary age-related tauopathy, we emphasize the public health impact of an underappreciated AD "mimic," which has been termed "hippocampal sclerosis of aging" or "hippocampal sclerosis dementia." This pathology affects >20% of individuals older than 85 years and is strongly associated with cognitive impairment. In this review, we provide an overview of current hypotheses about how genetic risk factors (GRN, TMEM106B, ABCC9, and KCNMB2), and other pathogenetic influences contribute to TDP-43 pathology and hippocampal sclerosis. Because hippocampal sclerosis of aging affects the "oldest-old" with arteriolosclerosis and TDP-43 pathologies that extend well beyond the hippocampus, more appropriate terminology for this disease is required. We recommend "cerebral age-related TDP-43 and sclerosis" (CARTS). A detailed case report is presented, which includes neuroimaging and longitudinal neurocognitive data. Finally, we suggest a neuropathology-based diagnostic rubric for CARTS. © 2016 American Association of Neuropathologists, Inc. All rights reserved.

  13. DeCART v1.2 User's Manual

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Kim, H. Y.; Lee, C. C.; Zee, S. Q; Joo, H. G

    2007-07-15

    DeCART (Deterministic Core Analysis based on Ray Tracing) is a whole core neutron transport code capable of direct subpin level flux calculation at power generating conditions. It does not require a priori homogenization nor group condensation needed in conventional reactor physics calculations. The depletion and transient calculation capabilities are also available. This manual serves as a self-sufficient guide to use the code. First of all, the various features of the code are explained which encompass various modeling options as well as the basic calculation functionalities. The instructions for running the code are also given with a description of the output files generated. Next, the underlying concepts and principles of preparing a DeCART model for a problem under consideration are presented. Each part of the input needed to specify the geometry, material composition, thermal operating condition, program execution control parameters are explained with examples. The descriptions of all the input cards are then followed. Finally, various sample model inputs ranging from a simple 2D pin cell to a realistic 3D core problem, steady-state to transient problems, and from rectangular to hexagonal core problems are presented.

  14. DeCART v1.1 user's manual

    Energy Technology Data Exchange (ETDEWEB)

    Cho, J. Y.; Kim, K. S.; Kim, H. Y.; Lee, C. C.; Zee, S. Q.; Joo, H. G

    2005-03-15

    DeCART (Deterministic Core Analysis based on Ray Tracing) is a whole core neutron transport code capable of direct subpin level flux calculation at power generating conditions. It does not require a priori homogenization nor group condensation needed in conventional reactor physics calculations. The depletion and transient calculation capabilities are also available. This manual serves as a self-sufficient guide to use the code. First of all, the various features of the code are explained which encompass various modeling options as well as the basic calculation functionalities. The instructions for running the code are also given with a description of the output files generated. Next, the underlying concepts and principles of preparing a DeCART model for a problem under consideration are presented. Each part of the input needed to specify the geometry, material composition, thermal operating condition, program execution control parameters are explained with examples. The descriptions of all the input cards are then followed. Finally, various sample model inputs ranging from a simple 2D pin cell to a realistic 3D core problem, steady-state to transient problems, are presented.

  15. Analyse des sous-performances energetiques d'eoliennes en utilisant des cartes de controle EWMA =

    Science.gov (United States)

    Lepvrier, Romain

    L'exploitation de l'energie eolienne est en forte croissance depuis plus de deux decennies. Beaucoup de centrales eoliennes ont ete construites durant cette periode. La tendance aujourd'hui est de surveiller les centrales eoliennes existantes pour obtenir la meilleure performance possible en assurant des conditions d'exploitation optimales et une grande disponibilite de l'equipement. Les recentes avancees technologiques n'ayant pas pu etre implantees a l'epoque ou ces centrales ont ete construites, par consequent, il faut trouver des outils d'analyses pour detecter, le plus precocement possible, les sous-performances des eoliennes et d'anticiper la correction les problemes d'une maniere preventive. En premiere partie, ce memoire presente la construction des courbes de puissance de reference pour un fonctionnement normal des machines. De l'obtention des donnees, provenant directement des eoliennes in-situ, a la courbe de puissance finale permettant l'eventuelle detection de sous-performances d'une maniere robuste et commode, tout le processus est decrit etape par etape. Dans une deuxieme partie, une carte de controle EWMA a ete developpee. A l'aide d'une methode graphique suivie d'un algorithme, elle permet de detecter les faibles sousperformances graduelles qui surviennent au cours du temps sur une eolienne. Il a ete montre que la carte developpee est capable de detecter un niveau de baisse de performance de 1 % par rapport a la performance normale de l'eolienne.

  16. It’s all change for the "carte de légitimation"

    CERN Document Server

    2009-01-01

    From now on, the Swiss carte de légitimation will be issued to associates and users as well as staff members, and applications will be handled electronically, thus facilitating various procedures. In collaboration with the GS-AIS Group, the HR Department is continuing its modernisation of administrative procedures. Now that MARS forms and applications to participate in the saved leave scheme have been computerised and employment certificates and change of home address forms have been made available on line on a self-service basis, it’s the turn of the carte de légitimation to enter the digital era. In future, when a new card needs to be produced, the member of the personnel’s data will be forwarded electronically from CERN’s database to the database of the Swiss Federal Department of Foreign Affairs (DFAE), eliminating the need for a paper form. Similarly, paper ID photos will no longer be needed as the digital photo taken for ...

  17. Short-Term High-Fat Diet Increases Leptin Activation of CART Neurons and Advances Puberty in Female Mice.

    Science.gov (United States)

    Venancio, Jade Cabestre; Margatho, Lisandra Oliveira; Rorato, Rodrigo; Rosales, Roberta Ribeiro Costa; Debarba, Lucas Kniess; Coletti, Ricardo; Antunes-Rodrigues, Jose; Elias, Carol F; Elias, Lucila Leico K

    2017-11-01

    Leptin is a permissive factor for puberty initiation, participating as a metabolic cue in the activation of the kisspeptin (Kiss1)-gonadotropin-releasing hormone neuronal circuitry; however, it has no direct effect on Kiss1 neurons. Leptin acts on hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons, participating in the regulation of energy homeostasis. We investigated the influence of a short-term high-fat diet (HFD) on the effect of leptin on puberty timing. Kiss1-hrGFP female mice received a HFD or regular diet (RD) after weaning at postnatal day (PN)21 and were studied at PN28 and PN32. The HFD increased body weight and plasma leptin concentrations and decreased the age at vaginal opening (HFD, 32 ± 0.53 days; RD, 38 ± 0.67 days). Similar colocalization of neurokinin B and dynorphin in Kiss1-hrGFP neurons of the arcuate nucleus (ARC) was observed between the HFD and RD groups. The HFD increased CART expression in the ARC and Kiss1 messenger RNA expression in the anteroventral periventricular (AVPV)/anterior periventricular (Pe). The HFD also increased the number of ARC CART neurons expressing leptin-induced phosphorylated STAT3 (signal transducer and activator of transcription 3) at PN32. Close apposition of CART fibers to Kiss1-hrGFP neurons was observed in the ARC of both RD- and HFD-fed mice. In conclusion, these data reinforce the notion that a HFD increases kisspeptin expression in the AVPV/Pe and advances puberty initiation. Furthermore, we have demonstrated that the HFD-induced earlier puberty is associated with an increase in CART expression in the ARC. Therefore, these data indicate that CART neurons in the ARC can mediate the effect of leptin on Kiss1 neurons in early puberty induced by a HFD. Copyright © 2017 Endocrine Society.

  18. Malignancies Trends in a Hispanic Cohort of HIV Persons in Puerto Rico before and after cART.

    Science.gov (United States)

    Mayor, Angel M; Santiago-Rodriguez, Eduardo J; Rios-Olivares, Eddy; Tortolero-Luna, Guillermo; Hunter-Mellado, Robert F

    2016-01-01

    The study describes the cancer trends in a Puerto Rican Hispanic HIV/AIDS cohort for three different time periods as defined by the availability of combination antiretroviral therapy (cART) in the Island: pre (1992-1995), early (1996-2002, and recent (2003-2009). AIDS and non-AIDS related malignancies risk, standardized incidence rate and one year mortality was evaluated in the cohort before and after cART. Of the 281 malignancies found in 265 persons; 72% were in men, 38% in injecting drug users and 42.3% were AIDS related cancers. AIDS related cancer standardized incidence rates decreased significantly in the cART eras; however, Kaposi's sarcoma and invasive cervical carcinoma incidence remained significantly higher in the cohort when compare to the general population. On the contrary, non-AIDS related cancer standardized incidence rates increased significantly in the cART eras, specifically those of the oral/cavity/pharynx, liver, anus, vaginal, and Hodgkin's and non-Hodgkin's Lymphomas. Around 50% of the persons with cancers were reported dead within the first year of their diagnoses without a significant variation during the cART eras. The higher incidence of Kaposi's sarcoma, invasive cervical carcinoma and non-AIDS related malignancies and their high mortality in the cART eras is suggestive of the role of oncogenic viruses, environmental agents, risky lifestyle behaviors and inadequate cancer prevention efforts that contribute and accelerate the risk of malignant transformation in these subjects. Aggressive intervention in the form of vaccines, risky practice reduction, early screening, early treatment and adequate risk reduction education needs to be incremented in this vulnerable population.

  19. The Rhode Island Consortium for Autism Research and Treatment (RI-CART): a new statewide autism collaborative.

    Science.gov (United States)

    Gerber, Alan; Morrow, Eric; Sheinkopf, Stephen J; Anders, Thomas

    2014-05-01

    Autism is a neurodevelopmental disorder characterized by core deficits in social interaction, language and repetitive behaviors. The need for services is rising sharply as the number of children identified with autism increases. The Rhode Island Consortium for Autism Research and Treatment (RI-CART) was founded in 2009 with the goal of increasing communication among autism researchers throughout the state and improving treatment for children with autism. RI-CART members have several exciting projects in progress, with its larger aim being the creation of a statewide research registry. A statewide registry would benefit research in Rhode Island and allow for larger collaborations nationally.

  20. Compra compulsiva e a influÃncia do cartÃo de crÃdito.

    OpenAIRE

    Cristiane Machado Veloso

    2009-01-01

    A compra compulsiva à um estado de descontrole, um transtorno no controle do impulso, que tem o intuito de minimizar sentimentos negativos. O cartÃo de crÃdito pode ser uma ferramenta que impulsiona o jovem a comprar mais, e se nÃo houver controle, pode gerar dÃvidas e problemas psicolÃgicos e familiares. Neste contexto, o cartÃo de crÃdito pode ser uma ferramenta influenciadora para os jovens com perfil de compradores compulsivos.O objetivo geral deste estudo foi analisar aspectos do comport...

  1. Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs - San Mateo testbed analysis plan : final report.

    Science.gov (United States)

    2016-06-29

    The primary objective of this project is to develop multiple simulation testbeds/transportation models to : evaluate the impacts of DMA connected vehicle applications and the active and dynamic transportation : management (ATDM) strategies. The outpu...

  2. Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs -- calibration report for San Mateo testbed.

    Science.gov (United States)

    2016-08-22

    The primary objective of this project is to develop multiple simulation Testbeds/transportation models to evaluate the impacts of DMA connected vehicle applications and the active and dynamic transportation management (ATDM) strategies. The outputs (...

  3. First results of the Test-Bed Telescopes (TBT) project: Cebreros telescope commissioning

    Science.gov (United States)

    Ocaña, Francisco; Ibarra, Aitor; Racero, Elena; Montero, Ángel; Doubek, Jirí; Ruiz, Vicente

    2016-07-01

    The TBT project is being developed under ESA's General Studies and Technology Programme (GSTP), and shall implement a test-bed for the validation of an autonomous optical observing system in a realistic scenario within the Space Situational Awareness (SSA) programme of the European Space Agency (ESA). The goal of the project is to provide two fully robotic telescopes, which will serve as prototypes for development of a future network. The system consists of two telescopes, one in Spain and the second one in the Southern Hemisphere. The telescope is a fast astrograph with a large Field of View (FoV) of 2.5 x 2.5 square-degrees and a plate scale of 2.2 arcsec/pixel. The tube is mounted on a fast direct-drive mount moving with speed up to 20 degrees per second. The focal plane hosts a 2-port 4K x 4K back-illuminated CCD with readout speeds up to 1MHz per port. All these characteristics ensure good survey performance for transients and fast moving objects. Detection software and hardware are optimised for the detection of NEOs and objects in high Earth orbits (objects moving from 0.1-40 arcsec/second). Nominal exposures are in the range from 2 to 30 seconds, depending on the observational strategy. Part of the validation scenario involves the scheduling concept integrated in the robotic operations for both sensors. Every night it takes all the input needed and prepares a schedule following predefined rules allocating tasks for the telescopes. Telescopes are managed by RTS2 control software, that performs the real-time scheduling of the observation and manages all the devices at the observatory.1 At the end of the night the observing systems report astrometric positions and photometry of the objects detected. The first telescope was installed in Cebreros Satellite Tracking Station in mid-2015. It is currently in the commissioning phase and we present here the first results of the telescope. We evaluate the site characteristics and the performance of the TBT Cebreros

  4. Wireless Spectrum Research & Development Senior Steering Group's Testbed Information Portal

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — This application contains a list of Federal R&D sites that are available for public-private collaborative research efforts in the field of spectrum and wireless...

  5. Social media analytics and research testbed (SMART): Exploring spatiotemporal patterns of human dynamics with geo-targeted social media messages

    OpenAIRE

    Jiue-An Yang; Ming-Hsiang Tsou; Chin-Te Jung; Christopher Allen; Brian H Spitzberg; Jean Mark Gawron; Su-Yeon Han

    2016-01-01

    The multilevel model of meme diffusion conceptualizes how mediated messages diffuse over time and space. As a pilot application of implementing the meme diffusion, we developed the social media analytics and research testbed to monitor Twitter messages and track the diffusion of information in and across different cities and geographic regions. Social media analytics and research testbed is an online geo-targeted search and analytics tool, including an automatic data processing procedure at t...

  6. Histoire maritime et cartes en ligne, du XVIe au XXIe siècle

    Directory of Open Access Journals (Sweden)

    César Ducruet

    2013-06-01

    Full Text Available Des informations plus ou moins anciennes sur les flux maritimes mondiaux sont aujourd’hui mobilisées à des fins très variées: pour analyser le climat d’après les journaux de bord, reconstituer le trafic entre les ports des différentes parties du monde, mesurer l’impact de l’activité humaine sur les milieux marins, etc. Beaucoup de ces données ont permis de concevoir des cartes, dont de nombreuses sont en ligne, ce qui permet de dresser un aperçu, forcément incomplet mais éclairant, de la diversité des ensembles de données accessibles pour des périodes longues (du XVIe siècle à aujourd’hui, et des formes de mise en valeur cartographique utilisées.

  7. [Current status and future development of CAR-T gene therapy].

    Science.gov (United States)

    Ozawa, Keiya

    2015-10-01

    Adoptive T-cell therapy using chimeric antigen receptor (CAR) technology is a novel approach to cancer immuno-gene therapy. CARs are hybrid proteins consisting of a target-antigen-specific single-chain antibody fragment fused to intracellular T-cell activation domains (CD28 or CD137/CD3ζ receptor). CAR-expressing engineered T lymphocytes can directly recognize and kill tumor cells in an HLA independent manner. In the United States, promising results have been obtained in clinical trials of adoptive immuno-gene therapy using CD19-CAR-T lymphocytes for the treatment of refractory B-cell malignancies, including chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), and malignant lymphoma.

  8. Food Environment in Secondary Schools: À La Carte, Vending Machines, and Food Policies and Practices

    Science.gov (United States)

    French, Simone A.; Story, Mary; Fulkerson, Jayne A.; Gerlach, Anne Faricy

    2003-01-01

    Objectives. This study described the food environment in 20 Minnesota secondary schools. Methods. Data were collected on school food policies and the availability and nutritional content of foods in school à la carte (ALC) areas and vending machines (VMs). Results. Approximately 36% and 35% of foods in ALC areas and in VMs, respectively, met the lower-fat criterion (≤ 5.5 fat grams/serving). The chips/crackers category constituted the largest share of ALC foods (11.5%). The median number of VMs per school was 12 (4 soft drink, 2 snack, 5 other). Few school food policies were reported. Conclusions. The availability of healthful foods and beverages in schools as well as school food policies that foster healthful food choices among students needs greater attention. PMID:12835203

  9. Genetic Algorithm Phase Retrieval for the Systematic Image-Based Optical Alignment Testbed

    Science.gov (United States)

    Taylor, Jaime; Rakoczy, John; Steincamp, James

    2003-01-01

    Phase retrieval requires calculation of the real-valued phase of the pupil fimction from the image intensity distribution and characteristics of an optical system. Genetic 'algorithms were used to solve two one-dimensional phase retrieval problem. A GA successfully estimated the coefficients of a polynomial expansion of the phase when the number of coefficients was correctly specified. A GA also successfully estimated the multiple p h e s of a segmented optical system analogous to the seven-mirror Systematic Image-Based Optical Alignment (SIBOA) testbed located at NASA s Marshall Space Flight Center. The SIBOA testbed was developed to investigate phase retrieval techniques. Tiphilt and piston motions of the mirrors accomplish phase corrections. A constant phase over each mirror can be achieved by an independent tip/tilt correction: the phase Conection term can then be factored out of the Discrete Fourier Tranform (DFT), greatly reducing computations.

  10. An Aircraft Electric Power Testbed for Validating Automatically Synthesized Reactive Control Protocols

    Science.gov (United States)

    2013-01-01

    we describe our recently developed simulation models and a hardware testbed for validating reactive controllers synthesized using TuLiP [1], a...temporal logic planning toolbox, in order to investigate the validity of the assumptions made in controller synthesis. TuLiP is a collection of Python... TuLiP can be used to synthesize logic so that the satisfaction of certain safety requirements is guaranteed. The synthesized logic enables the contac

  11. The end-to-end testbed of the optical metrology system on-board LISA Pathfinder

    Energy Technology Data Exchange (ETDEWEB)

    Steier, F; Cervantes, F Guzman; Marin, A F GarcIa; Heinzel, G; Danzmann, K [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut) and Universitaet Hannover (Germany); Gerardi, D, E-mail: frank.steier@aei.mpg.d [EADS Astrium Satellites GmbH, Friedrichshafen (Germany)

    2009-05-07

    LISA Pathfinder is a technology demonstration mission for the Laser Interferometer Space Antenna (LISA). The main experiment on-board LISA Pathfinder is the so-called LISA Technology Package (LTP) which has the aim to measure the differential acceleration between two free-falling test masses with an accuracy of 3 x 10{sup -14} ms{sup -2} Hz{sup -1/2} between 1 mHz and 30 mHz. This measurement is performed interferometrically by the optical metrology system (OMS) on-board LISA Pathfinder. In this paper, we present the development of an experimental end-to-end testbed of the entire OMS. It includes the interferometer and its sub-units, the interferometer backend which is a phasemeter and the processing of the phasemeter output data. Furthermore, three-axes piezo-actuated mirrors are used instead of the free-falling test masses for the characterization of the dynamic behaviour of the system and some parts of the drag-free and attitude control system (DFACS) which controls the test masses and the satellite. The end-to-end testbed includes all parts of the LTP that can reasonably be tested on earth without free-falling test masses. At its present status it consists mainly of breadboard components. Some of those have already been replaced by engineering models of the LTP experiment. In the next steps, further engineering and flight models will also be inserted in this testbed and tested against well-characterized breadboard components. The presented testbed is an important reference for the unit tests and can also be used for validation of the on-board experiment during the mission.

  12. ASE-BAN, a Wireless Body Area Network Testbed

    DEFF Research Database (Denmark)

    Madsen, Jens Kargaard; Karstoft, Henrik; Hansen, Finn Overgaard

    2010-01-01

    /actuators attached to the body and a host server application. The gateway uses the BlackFin BF533 processor from Analog Devices, and uses Bluetooth for wireless communication. Two types of sensors are attached to the network: an electro-cardio-gram sensor and an oximeter sensor. The testbed has been successfully...... tested for electro-cardio-gram data collection, and using wireless communication in a battery powered configuration....

  13. Development of an Experimental Testbed for Research in Lithium-Ion Battery Management Systems

    Directory of Open Access Journals (Sweden)

    Mehdi Ferdowsi

    2013-10-01

    Full Text Available Advanced electrochemical batteries are becoming an integral part of a wide range of applications from household and commercial to smart grid, transportation, and aerospace applications. Among different battery technologies, lithium-ion (Li-ion batteries are growing more and more popular due to their high energy density, high galvanic potential, low self-discharge, low weight, and the fact that they have almost no memory effect. However, one of the main obstacles facing the widespread commercialization of Li-ion batteries is the design of reliable battery management systems (BMSs. An efficient BMS ensures electrical safety during operation, while increasing battery lifetime, capacity and thermal stability. Despite the need for extensive research in this field, the majority of research conducted on Li-ion battery packs and BMS are proprietary works conducted by manufacturers. The available literature, however, provides either general descriptions or detailed analysis of individual components of the battery system, and ignores addressing details of the overall system development. This paper addresses the development of an experimental research testbed for studying Li-ion batteries and their BMS design. The testbed can be configured in a variety of cell and pack architectures, allowing for a wide range of BMS monitoring, diagnostics, and control technologies to be tested and analyzed. General considerations that should be taken into account while designing Li-ion battery systems are reviewed and different technologies and challenges commonly encountered in Li-ion battery systems are investigated. This testbed facilitates future development of more practical and improved BMS technologies with the aim of increasing the safety, reliability, and efficiency of existing Li-ion battery systems. Experimental results of initial tests performed on the system are used to demonstrate some of the capabilities of the developed research testbed. To the authors

  14. Gowdy waves as a test-bed for constraint-preserving boundary conditions

    CERN Document Server

    Bona, C

    2010-01-01

    Gowdy waves, one of the standard 'apples with apples' tests, is proposed as a test-bed for constraint-preserving boundary conditions in the non-linear regime. As an illustration, energy-constraint preservation is separately tested in the Z4 framework. Both algebraic conditions, derived from energy estimates, and derivative conditions, deduced from the constraint-propagation system, are considered. The numerical errors at the boundary are of the same order than those at the interior points.

  15. Designing and Building SDN Testbeds for Energy-Aware Traffic Engineering Services

    OpenAIRE

    Dias De Assuncao, Marcos; Carpa, Radu; Lefèvre, Laurent; Glück, Olivier; Borylo, Piotr; Lason, Artur; Szymanski, Andrzej; Rzepka, Michal

    2017-01-01

    International audience; As experimenting with energy-aware techniques on large-scale production infrastructure is prohibitive , a large number of proposed traffic-engineering strategies have been evaluated only using discrete-event simulations. The present work discusses (i) challenges towards building testbeds that allow researchers and practitioners to validate and evaluate the performance and quality of energy-aware traffic-engineering strategies , (ii) requirements to fulfill when porting...

  16. Hypothalamic neuronal origin of neuropeptide Y (NPY) or cocaine- and amphetamine-regulated transcript (CART) fibers projecting to the tuberomammillary nucleus of the rat.

    Science.gov (United States)

    Lee, Eun Y; Hwang, Young G; Lee, Hyun S

    2017-02-15

    Based on the importance of tuberomammillary nucleus (TMN) as a target for feeding/arousal-related functions, we aimed in the present study to investigate hypothalamic neuronal origin of neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) fibers projecting to the histaminergic nucleus. In the first series of experiments, we examined NPY (or CART) fiber distribution within the boundary of adenosine deaminase (ADA)-immunoreactive (ir) TMN regions; extensive NPY (or CART)-ir axon terminals were observed in E4 (TMMd), E3 (TMMv), and E2 (TMVr) subdivisions. NPY varicosities co-contained vesicular GABA transporters (vGAT). CART boutons, however, contained either vGAT or vesicular glutamate transporters (vGLU), which suggested dual (or multiple) origins of CART fibers. Based on the previous observation on melanin-concentrating hormone (MCH)-ir neuronal elements in the TMN, their coexistence with CART peptide was examined in detail. In E4 subdivision, approximately 40.8% of MCH-ir somata co-contained CART, but the proportion was reduced to 24.1% in E3 region. In E2 and E1 (TMVc) regions, only MCH-ir axon terminals existed without any MCH-ir somata. In the second series of experiments, we investigated hypothalamic neuronal origin of NPY (or CART) fibers projecting to the TMN. The arcuate nucleus (Arc) was the sole source of hypothalamic NPY fibers projecting to the nucleus. In contrast, CART fibers in the TMN originated from the Arc as well as the other hypothalamic nuclei including the retrochiasmatic nucleus, paraventricular nucleus, lateral hypothalamus (LH), zona incerta (ZI), and dorsal hypothalamic area. Quantitative analysis showed that arcuate CART projection to the TMN occupied approximately 23.5% of the total hypothalamic CART input to the nucleus, while the rest originated mainly from the LH and ZI. The present observations suggested that the TMN might play a key role in energy balance and arousal, by receiving periphery-derived, first

  17. Differences in CART expression and cell cycle behavior discriminate sympathetic neuroblast from chromaffin cell lineages in mouse sympathoadrenal cells.

    Science.gov (United States)

    Chan, Wing Hei; Gonsalvez, David G; Young, Heather M; Southard-Smith, E Michelle; Cane, Kylie N; Anderson, Colin R

    2016-02-01

    Adrenal medullary chromaffin cells and peripheral sympathetic neurons originate from a common sympathoadrenal (SA) progenitor cell. The timing and phenotypic changes that mark this lineage diversification are not fully understood. The present study investigated the expression patterns of phenotypic markers, and cell cycle dynamics, in the adrenal medulla and the neighboring suprarenal ganglion of embryonic mice. The noradrenergic marker, tyrosine hydroxylase (TH), was detected in both presumptive adrenal medulla and sympathetic ganglion cells, but with significantly stronger immunostaining in the former. There was intense cocaine and amphetamine-regulated transcript (CART) peptide immunostaining in most neuroblasts, whereas very few adrenal chromaffin cells showed detectable CART immunostaining. This phenotypic segregation appeared as early as E12.5, before anatomical segregation of the two cell types. Cell cycle dynamics were also examined. Initially, 88% of Sox10 positive (+) neural crest progenitors were proliferating at E10.5. Many SA progenitor cells withdrew from the cell cycle at E11.5 as they started to express TH. Whereas 70% of neuroblasts (TH+/CART+ cells) were back in the cell cycle at E12.5, only around 20% of chromaffin (CART negative) cells were in the cell cycle at E12.5 and subsequent days. Thus, chromaffin cell and neuroblast lineages showed differences in proliferative behavior from their earliest appearance. We conclude that the intensity of TH immunostaining and the expression of CART permit early discrimination of chromaffin cells and sympathetic neuroblasts, and that developing chromaffin cells exhibit significantly lower proliferative activity relative to sympathetic neuroblasts. © 2015 Wiley Periodicals, Inc.

  18. High Contrast Vacuum Nuller Testbed (VNT) Contrast, Performance and Null Control

    Science.gov (United States)

    Lyon, Richard G.; Clampin, Mark; Petrone, Peter; Mallik, Udayan; Madison, Timothy; Bolcar, Matthew R.

    2012-01-01

    Herein we report on our Visible Nulling Coronagraph high-contrast result of 109 contrast averaged over a focal planeregion extending from 14 D with the Vacuum Nuller Testbed (VNT) in a vibration isolated vacuum chamber. TheVNC is a hybrid interferometriccoronagraphic approach for exoplanet science. It operates with high Lyot stopefficiency for filled, segmented and sparse or diluted-aperture telescopes, thereby spanning the range of potential futureNASA flight telescopes. NASAGoddard Space Flight Center (GSFC) has a well-established effort to develop the VNCand its technologies, and has developed an incremental sequence of VNC testbeds to advance this approach and itsenabling technologies. These testbeds have enabled advancement of high-contrast, visible light, nulling interferometry tounprecedented levels. The VNC is based on a modified Mach-Zehnder nulling interferometer, with a W configurationto accommodate a hex-packed MEMS based deformable mirror, a coherent fiber bundle and achromatic phase shifters.We give an overview of the VNT and discuss the high-contrast laboratory results, the optical configuration, criticaltechnologies and null sensing and control.

  19. James Webb Space Telescope Optical Simulation Testbed: Segmented Mirror Phase Retrieval Testing

    Science.gov (United States)

    Laginja, Iva; Egron, Sylvain; Brady, Greg; Soummer, Remi; Lajoie, Charles-Philippe; Bonnefois, Aurélie; Long, Joseph; Michau, Vincent; Choquet, Elodie; Ferrari, Marc; Leboulleux, Lucie; Mazoyer, Johan; N’Diaye, Mamadou; Perrin, Marshall; Petrone, Peter; Pueyo, Laurent; Sivaramakrishnan, Anand

    2018-01-01

    The James Webb Space Telescope (JWST) Optical Simulation Testbed (JOST) is a hardware simulator designed to produce JWST-like images. A model of the JWST three mirror anastigmat is realized with three lenses in form of a Cooke Triplet, which provides JWST-like optical quality over a field equivalent to a NIRCam module, and an Iris AO segmented mirror with hexagonal elements is standing in for the JWST segmented primary. This setup successfully produces images extremely similar to NIRCam images from cryotesting in terms of the PSF morphology and sampling relative to the diffraction limit.The testbed is used for staff training of the wavefront sensing and control (WFS&C) team and for independent analysis of WFS&C scenarios of the JWST. Algorithms like geometric phase retrieval (GPR) that may be used in flight and potential upgrades to JWST WFS&C will be explored. We report on the current status of the testbed after alignment, implementation of the segmented mirror, and testing of phase retrieval techniques.This optical bench complements other work at the Makidon laboratory at the Space Telescope Science Institute, including the investigation of coronagraphy for segmented aperture telescopes. Beyond JWST we intend to use JOST for WFS&C studies for future large segmented space telescopes such as LUVOIR.

  20. Variable Coding and Modulation Experiment Using NASA's Space Communication and Navigation Testbed

    Science.gov (United States)

    Downey, Joseph A.; Mortensen, Dale J.; Evans, Michael A.; Tollis, Nicholas S.

    2016-01-01

    National Aeronautics and Space Administration (NASA)'s Space Communication and Navigation Testbed on the International Space Station provides a unique opportunity to evaluate advanced communication techniques in an operational system. The experimental nature of the Testbed allows for rapid demonstrations while using flight hardware in a deployed system within NASA's networks. One example is variable coding and modulation, which is a method to increase data-throughput in a communication link. This paper describes recent flight testing with variable coding and modulation over S-band using a direct-to-earth link between the SCaN Testbed and the Glenn Research Center. The testing leverages the established Digital Video Broadcasting Second Generation (DVB-S2) standard to provide various modulation and coding options. The experiment was conducted in a challenging environment due to the multipath and shadowing caused by the International Space Station structure. Performance of the variable coding and modulation system is evaluated and compared to the capacity of the link, as well as standard NASA waveforms.

  1. Actual use of and satisfaction associated with rollators and "shopping carts" among frail elderly Japanese people using day-service facilities.

    Science.gov (United States)

    Kitajima, Eiji; Moriuchi, Takefumi; Iso, Naoki; Sagari, Akira; Kikuchi, Yasuyuki; Higashi, Toshio

    2017-07-01

    Purpose This study aimed at clarifying the actual use of and satisfaction with rollators and "shopping carts" (wheeled walkers with storage) among frail elderly people, who were certified by a long-term care insurance system as users of facilities that provide day-service nursing care and rehabilitation. Methods We identified 1247 frail elderly people who used day-service facilities, and evaluated their actual use of, and satisfaction with, rollators and shopping carts. Results Forty-four (3.5%) individuals used rollators, and 53 (4.3%) used shopping carts. The shopping cart group contained more individuals who were certified as care level 1 (26.4%), than the rollator group (20.5%), and 52.8% of the shopping cart group was certified as care levels 1-3. The scores for "repairs and services" and "follow-up" from the Quebec User Evaluation of Satisfaction with assistive Technology second version (QUEST 2.0) survey were significantly higher in the rollator group than in the shopping cart group. Conclusions The QUEST 2.0 scores revealed that shopping cart users exhibit insufficient "repairs and services" and "follow-up" scores. As frail elderly people with poor care status accounted for >50% of the shopping cart group, these individuals urgently need walking aids that are tailored to their care status. Implications for Rehabilitation We conclude that walking aid fitting must be tailored to each persons care status, and suggest that a system should be established to allow occupational or physical therapists to provide this fitting Moreover, our analysis of the QUEST2.0 service scores revealed that repairs, services, and follow-up are insufficient to meet the needs of shopping cart users.

  2. Relationship between antiretrovirals used as part of a cART regimen and CD4 count increases in patients with suppressed viremia

    DEFF Research Database (Denmark)

    Mocroft, A; Phillips, A; Ledergerber, B

    2006-01-01

    BACKGROUND: It is unknown if the CD4 cell count response differs according to antiretroviral drugs used in combination antiretroviral therapy (cART) in patients with maximal virological suppression [viral load (VL) < 50 copies/ml]. OBJECTIVES: To compare the change in CD4 cell count over consecut......BACKGROUND: It is unknown if the CD4 cell count response differs according to antiretroviral drugs used in combination antiretroviral therapy (cART) in patients with maximal virological suppression [viral load (VL) ... from starting cART, age, CD4 at first VL ART. RESULTS: We studied 28418 instances of VL

  3. Lecture matérialiste des Méditations cartésiennes

    Directory of Open Access Journals (Sweden)

    Anne Staquet

    2009-08-01

    Full Text Available Lorsque, à de rares occasions, on envisage le caractère matérialiste de la pensée cartésienne, c'est systématiquement en s'appuyant sur ses textes scientifiques. Les textes plus philosophiques sont dans cette perspective laissés de côté, voire déconsidérés comme le montre de manière exacerbée  Hiram Caton, qui discrédite les Méditations sous prétexte qu'elle ne seraient écrites que pour endormir la censure et acheter une réputation à leur auteur et n'ont donc aucune pertinence philosophique. Or, Descartes n'a cessé d'insister sur l'importance de relier ses deux types écrits : les plus scientifiques et les plus métaphysiques. C'est la raison pour laquelle, à l'inverse de ces considérations, je propose de tenter une lecture matérialiste (au sens leibnizien du terme des Méditations métaphysiques. Pour ce faire, m'appuyant sur les paroles mêmes de Descartes, je commencerai par montrer l'usage que fait le philosophe de la dissimulation dans l'ensemble de ses œuvres. Je montrerai ensuite comment le dualisme cartésien permet de fonder un matérialisme. Et je terminerai en montrant comment les preuves de l'existence de Dieu et la distinction âme-corps ne contredisent en fait pas réellement une lecture matérialiste des Méditations cartésiennes.Materialistic interpretation of the Cartesian MéditationsWhen, on rare occasions, we consider the materialistic nature of the Cartesian thinking, we systematically refer to scientific texts. In this perspective, more philosophical texts are not taken into consideration or are even ignored, as Hiram Caton showed it by discrediting the Méditations because they would only have been written to dupe the censure and buy a reputation for their author. They would therefore have no philosphical pertinence at all. But Descartes never stopped to insist on the importance of combining both writing types: the scientific one and the metaphysical one. For that reason, contrary to these

  4. Veulent-ils encore une carte de presse ? Les jeunes journalistes de Belgique francophone

    Directory of Open Access Journals (Sweden)

    Olivier Standaert

    2013-12-01

    Full Text Available Cet article questionne les formes identitaires développées par les jeunes journalistesbelges lorsque se pose à eux la question de la possession de la carte de presse. La méthodologie s’appuie sur une étude descriptive du profil professionnel des jeunes journalistes et sur des entretiens non directifs menés auprès de journalistes, encartés ou non, ayant moins de cinq ans d’ancienneté. Il apparaît qu’une part importante d’entre eux ne répond plus, et ce durant une période de plus en plus longue, aux critères stricts d’obtention de la carte de presse tels que définis par les autorités belges. La carte de presse est par conséquent souvent sollicitée après l’insertion effective sur le marché du travail. Ceci peut s’expliquer par la précarisation des conditions d’insertion dans le groupe professionnel des journalistes. La montée de la précarisation au sein des médias d’information générale est une des hypothèses explicatives du décalage fréquemment constaté entre les formes identitaires traditionnelles, attachées à la carte de presse, et celles des jeunes journalistes, dominées par la figure de l’individu précaire, flexible et substituable en dépit d’une vocation affichée. Les entretiens mettent cependant en évidence un discours ambivalent où une rhétorique d’indifférence, de questionnement, voire de rejet par rapport à tout document se donnant un pouvoir d’authentifier qui est journaliste et qui ne l’est pas, côtoie un discours de conciliation et d’adhésion, mettant en avant la force symbolique de cette carte et la forme d’aboutissement identitaire que sa délivrance continue d’incarner. Il est significatif de noter que les instances d’agréation adaptent leurs pratiques, plus que leurs discours, à ces nouvelles situations professionnelles et aux identités qui en découlent : la délivrance de la carte de presse se fait de plus en plus au cas par cas, et avec une certaine

  5. MARS: a cabled observatory testbed in Monterey Bay

    Science.gov (United States)

    McNutt, M.; Massion, G.; Raybould, K.; Bellingham, J.; Paull, C.

    2003-04-01

    With funding from the U.S. National Science Foundation and the David and Lucile Packard Foundation, the Monterey Bay Aquarium Research Institute (MBARI) will be installing a deep-sea observatory in Monterey Bay, California, that will serve as a test bed for a future regional-scale cabled observatory. Monterey Bay offers a variety of active processes for scientific inquiry, including a very productive zone of ocean upwelling, a seismically active strand of the San Andreas fault system, cold seeps, and a very dynamic submarine canyon. The MARS (Monterey Accelerated Research System) cable will extend more than 60 km offshore to an instrument node at a depth of approximately 1.2 km. Extension cords can be run by remotely operated vehicles (ROVs) from the cable node up to several kilometers away in order to provide greater flexibility in siting instruments. The observatory will be serviced using ROVs and will serve as a test bed for developing new sensors, instruments systems, experiment protocols, and mobile platforms for which submarine cables will provide power and two-way communications. In addition to serving as a test bed for instrumentation and platforms, the MARS project will demonstrate models for how to operate, service, and manage a community facility of this sort. In cooperation with our outreach partner, the Monterey Bay Aquarium, we will be examining ways to exploit the full potential of deep-sea observatories for student education and public information. We will also be preparing a proposal to the Integrated Ocean Drilling Program (IODP) to provide a nearby drill hole for connecting bore-hole experiments to the MARS cable, thereby accelerating the development of new tools for probing Earth beneath the oceans.

  6. Social media analytics and research testbed (SMART: Exploring spatiotemporal patterns of human dynamics with geo-targeted social media messages

    Directory of Open Access Journals (Sweden)

    Jiue-An Yang

    2016-06-01

    Full Text Available The multilevel model of meme diffusion conceptualizes how mediated messages diffuse over time and space. As a pilot application of implementing the meme diffusion, we developed the social media analytics and research testbed to monitor Twitter messages and track the diffusion of information in and across different cities and geographic regions. Social media analytics and research testbed is an online geo-targeted search and analytics tool, including an automatic data processing procedure at the backend and an interactive frontend user interface. Social media analytics and research testbed is initially designed to facilitate (1 searching and geo-locating tweet topics and terms in different cities and geographic regions; (2 filtering noise from raw data (such as removing redundant retweets and using machine learning methods to improve precision; (3 analyzing social media data from a spatiotemporal perspective; and (4 visualizing social media data in diagnostic ways (such as weekly and monthly trends, trend maps, top media, top retweets, top mentions, or top hashtags. Social media analytics and research testbed provides researchers and domain experts with a tool that can efficiently facilitate the refinement, formalization, and testing of research hypotheses or questions. Three case studies (flu outbreaks, Ebola epidemic, and marijuana legalization are introduced to illustrate how the predictions of meme diffusion can be examined and to demonstrate the potentials and key functions of social media analytics and research testbed.

  7. The cost of a combination Anti-Retroviral Therapy (cART optimization pathway as maintenance therapy in HIV-1 infected patients

    Directory of Open Access Journals (Sweden)

    Roberto Ravasio

    2017-11-01

    CONCLUSIONS: From the Italian NHS’s perspective, the adoption of a specific cART optimization pathway represents a cost-saving option as maintenance antiretroviral therapy in HIV-1 infected patients.

  8. A la carte -ruokalistan ja annoskorttien suunnittelu : Case: Lomayhtymä Finland Oy / Kylpylä Kivitippu

    OpenAIRE

    Hautala, Satu

    2014-01-01

    Opinnäytetyön tavoitteena oli suunnitella ja kehittää uusi a la carte -ruokalista Kylpylä Kivitippuun Lappajärvelle. Ravintolan ruokalista on pysynyt samantapaisena jo useamman vuoden ajan, joten toimeksiantaja halusi, että ruokalistaa uudistetaan. Työn tavoitteena oli suunnitella uusi ruokalista, joka olisi samantyylinen kuin aikaisemmat ruokalistat ja samalla tehden ruokalistan annoksista nykyaikaisempia ja modernimpia. Samalla suunniteltiin ja tehtiin selkeät annoskortit, joissa on anno...

  9. Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response.

    Science.gov (United States)

    Xue, Qiong; Bettini, Emily; Paczkowski, Patrick; Ng, Colin; Kaiser, Alaina; McConnell, Timothy; Kodrasi, Olja; Quigley, Máire F; Heath, James; Fan, Rong; Mackay, Sean; Dudley, Mark E; Kassim, Sadik H; Zhou, Jing

    2017-11-21

    It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency and immunotoxicity ex vivo, despite promising in vivo efficacy in patients with B cell malignancies. We employed a single-cell, 16-plex cytokine microfluidics device and new analysis techniques to evaluate the functional profile of CD19 CAR-T cells upon antigen-specific stimulation. CAR-T cells were manufactured from human PBMCs transfected with the lentivirus encoding the CD19-BB-z transgene and expanded with anti-CD3/anti-CD28 coated beads. The enriched CAR-T cells were stimulated with anti-CAR or control IgG beads, stained with anti-CD4 RPE and anti-CD8 Alexa Fluor 647 antibodies, and incubated for 16 h in a single-cell barcode chip (SCBC). Each SCBC contains ~12,000 microchambers, covered with a glass slide that was pre-patterned with a complete copy of a 16-plex antibody array. Protein secretions from single CAR-T cells were captured and subsequently analyzed using proprietary software and new visualization methods. We demonstrate a new method for single-cell profiling of CD19 CAR-T pre-infusion products prepared from 4 healthy donors. CAR-T single cells exhibited a marked heterogeneity of cytokine secretions and polyfunctional (2+ cytokine) subsets specific to anti-CAR bead stimulation. The breadth of responses includes anti-tumor effector (Granzyme B, IFN-γ, MIP-1α, TNF-α), stimulatory (GM-CSF, IL-2, IL-8), regulatory (IL-4, IL-13, IL-22), and inflammatory (IL-6, IL-17A) functions. Furthermore, we developed two new bioinformatics tools for more effective polyfunctional subset visualization and comparison between donors. Single-cell, multiplexed, proteomic profiling of CD19 CAR-T product reveals a diverse landscape of immune effector response of CD19 CAR-T cells to antigen-specific challenge, providing a new platform for capturing CAR-T product data for correlative analysis. Additionally, such high

  10. FY16 Safeguards Technology Cart-Portable Mass Spectrometer Project Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, Cyril V. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Whitten, William B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-02-01

    The Oak Ridge National Laboratory project for the Next Generation Safeguards Initiative Safeguards Technology Development Subprogram has been involved in the development of a cart portable mass spectrometer based on a Thermo ITQ ion trap mass spectrometer (referred to simply as the ITQ) for the field analysis of 235U/238U ratios in UF6. A recent discovery of the project was that combining CO2 with UF6 and introducing the mixture to the mass spectrometer (MS) appeared to increase the ionization efficiency and, thus, reduce the amount of UF6 needed for an analysis while also reducing the corrosive effects of the sample. However, initial experimentation indicated that mixing parameters should be closely controlled to ensure reproducible results. To this end, a sample manifold (SM) that would ensure the precise mixing of UF6 and CO2 was designed and constructed. A number of experiments were outlined and conducted to determine optimum MS and SM conditions which would provide the most stable isotope ratio analysis. The principal objective of the project was to provide a retrofit ITQ mass spectrometer operating with a SM capable of achieving a variation in precision of less than 1% over 1 hour of sampling. This goal was achieved by project end with a variation in precision of 0.5 to 0.8% over 1 hour of sampling.

  11. Bacterial Contamination and Disinfection Status of Laryngoscopes Stored in Emergency Crash Carts

    Directory of Open Access Journals (Sweden)

    Jae Hyung Choi

    2017-05-01

    Full Text Available Objectives To identify bacterial contamination rates of laryngoscope blades and handles stored in emergency crash carts by hospital and area according to the frequency of intubation attempts. Methods One hundred forty-eight handles and 71 blades deemed ready for patient use from two tertiary hospitals were sampled with sterile swabs using a standardized rolling technique. Samples were considered negative (not contaminated if no colonies were present on the blood agar plate after an 18-hour incubation period. Samples were stratified by hospital and according to the frequency of intubation attempts (10 attempts per year using the χ2-test and Fisher exact test. Results One or more species of bacteria were isolated from 4 (5.6% handle tops, 20 (28.2% handles with knurled surfaces, and 27 (18.2% blades. No significant differences were found in microbial contamination levels on the handle tops and blades between the two hospitals and two areas according to the frequency of intubation attempts. However, significant differences were found between the two hospitals and two areas in the level of microbial contamination on the handles with knurled surfaces (p<0.05. Conclusions Protocols and policies must be reviewed to standardize procedures to clean and disinfect laryngoscope blades and handles; handles should be re-designed to eliminate points of contact with the blade; and single-use, one-piece laryngoscopes should be introduced.

  12. Delay in the issuing of D-type Swiss cartes de légitimation

    CERN Multimedia

    DSU Department

    2007-01-01

    The Permanent Mission of Switzerland to the International Organisations in Geneva has informed CERN that, for technical reasons, the Federal Department of Foreign Affairs (Département fédéral des Affaires étrangères - DFAE) will be unable to issue D-type cartes de légitimation until after 15 December 2007. This is because, following the introduction of a new graphic design decided by the Swiss Federal Council, stocks of this type of card have run out. In the meantime, the Mission will issue E-type cards to the individuals concerned. These are valid for six months and will be gradually exchanged for D-type cards between December 2007 and February 2008. The Mission points out that the holding of an E-type card for a limited period will have no impact on the status of the officials in question, who will continue to benefit from immunity from jurisdiction in the discharge of their duties and be exempt from the payment of the annual tax on vehicles (a special note to this e...

  13. Delay In The Issuing Of D-Type Swiss Cartes De Legitimation

    CERN Multimedia

    DSU Department

    2007-01-01

    The Permanent Mission of Switzerland to the International Organisations in Geneva has informed CERN that, for technical reasons, the Federal Department of Foreign Affairs (Département fédéral des Affaires étrangères - DFAE) will be unable to issue D-type cartes de légitimation until after 15 December 2007. This is because, following the introduction of a new graphic design decided by the Swiss Federal Council, stocks of this type of card have run out. In the meantime, the Mission will issue E-type cards to the individuals concerned. These are valid for six months and will be gradually exchanged for D-type cards between December 2007 and February 2008. The Mission points out that the holding of an E-type card for a limited period will have no impact on the status of the officials in question, who will continue to benefit from immunity from jurisdiction in the discharge of their duties and be exempt from the payment of the annual tax on vehicles (a special note to this effect will be sent to the relevant...

  14. Hybrid thermochemical/biological processing: putting the cart before the horse?

    Science.gov (United States)

    Brown, Robert C

    2007-04-01

    The conventional view of biorefineries is that lignocellulosic plant material will be fractionated into cellulose, hemicellulose, lignin, and terpenes before these components are biochemically converted into market products. Occasionally, these plants include a thermochemical step at the end of the process to convert recalcitrant plant components or mixed waste streams into heat to meet thermal energy demands elsewhere in the facility. However, another possibility for converting high-fiber plant materials is to start by thermochemically processing it into a uniform intermediate product that can be biologically converted into a bio-based product. This alternative route to bio-based products is known as hybrid thermochemical/biological processing. There are two distinct approaches to hybrid processing: (a) gasification followed by fermentation of the resulting gaseous mixture of carbon monoxide (CO), hydrogen (H(2)), and carbon dioxide (CO(2)) and (b) fast pyrolysis followed by hydrolysis and/or fermentation of the anhydrosugars found in the resulting bio-oil. This article explores this "cart before the horse" approach to biorefineries.

  15. The Potsdam plates of the Carte du Ciel project: I. Present inventory and plate catalogue

    Science.gov (United States)

    Tsvetkova, K.; Tsvetkov, M.; Böhm, P.; Steinmetz, M.; Dick, W. R.

    2009-10-01

    We present an inventory of the Carte du Ciel (CdC) plates stored in the Astrophysical Institute Potsdam. The Potsdam CdC zone (+32° to +39°) was divided into 1232 areas and about 2200 plates from the first and second epochs were obtained within the framework of the CdC project. At present, only 977 plates (45% of all) are stored in AIP, the others got lost during the Second World War. The plates for the first epoch measurements had been obtained during the period 1893 May-1900 February. The plates for the second epoch (1913 August-1924 February) can be separated into two time intervals according to the observer and the observing method used: from 1913 August till 1914 July, and from 1916 February to 1924 February. The present work aims to provide online access to the plate information, given in the plate catalogue and is the first step to online access to the plate images digitized with flatbed scanners.

  16. The CARTS study: Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery

    Directory of Open Access Journals (Sweden)

    Bökkerink Guus MJ

    2011-12-01

    Full Text Available Abstract Background The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer. Methods/Design Patients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy (25 fractions of 2 Gy with concurrent capecitabine. Transanal Endoscopic Microsurgery (TEM will be performed 8 - 10 weeks after the end of the preoperative treatment depending on the clinical response. Primary objective is to determine the number of patients with a (near complete pathological response after chemoradiation therapy and TEM. Secondary objectives are the local recurrence rate and quality of life after this combined therapeutic modality. A three-step analysis will be performed after 20, 33 and 55 patients to ensure the feasibility of this treatment protocol. Discussion The CARTS-study is one of the first prospective multicentre trials to investigate the role of a rectum saving treatment modality using chemoradiation therapy and local excision. The CARTS study is registered at clinicaltrials.gov (NCT01273051

  17. Classication of Status of the Region on Java Island using C4.5, CHAID, and CART Methods

    Science.gov (United States)

    Syaraswati, R. A.; Slamet, I.; Winarno, B.

    2017-06-01

    The indicator of region economic success can be measured by economic growth, presented by value of Gross Regional Domestic Product (GRDP). Java island has the biggest GDP contribution toward the Indonesian government, but not all of the region gives equality contribution. The C4.5, CHAID, and CART methods can be used for classifying the status of the region with nonparametric approach. The C4.5 and CHAID methods are non-binary decision tree, meanwhile the CART methods is binary decision tree. The purposes of this paper are to know how the classification and to determine the factors that influence on classification of the region. The dependent variable is status of the region which is divided into four categories based on Klassen typology. The result shows factors that have the biggest contribution on classification of status of the region on Java island based on C4.5 method are economic growth rate, electricity, gas, and water sector, and area. The factors that have the biggest contribution based on CHAID method are growth rate, manufacturing sector, and electricity, gas, and water sector, while based on CART method are growth rate, manufacturing sector, and electricity, gas, and water sector.

  18. Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus.

    Science.gov (United States)

    Akieda-Asai, Sayaka; Poleni, Paul-Emile; Date, Yukari

    2014-06-01

    CCK and leptin are anorectic hormones produced in the small intestine and white adipose tissue, respectively. Investigating how these hormones act together as an integrated anorectic signal is important for elucidating the mechanisms by which energy balance is maintained. We found here that coadministration of subthreshold CCK and leptin, which individually have no effect on feeding, dramatically reduced food intake in rats. Phosphorylation of AMP-activated protein kinase (AMPK) in the hypothalamus significantly decreased after coinjection of CCK and leptin. In addition, coadministration of these hormones significantly increased mRNA levels of anorectic cocaine- and amphetamine-regulated transcript (CART) and thyrotropin-releasing hormone (TRH) in the hypothalamus. The interactive effect of CCK and leptin on food intake was abolished by intracerebroventricular preadministration of the AMPK activator AICAR or anti-CART/anti-TRH antibodies. These findings indicate that coinjection of CCK and leptin reduces food intake via reduced AMPK phosphorylation and increased CART/TRH in the hypothalamus. Furthermore, by using midbrain-transected rats, we investigated the role of the neural pathway from the hindbrain to the hypothalamus in the interaction of CCK and leptin to reduce food intake. Food intake reduction induced by coinjection of CCK and leptin was blocked in midbrain-transected rats. Therefore, the neural pathway from hindbrain to hypothalamus plays an important role in transmitting the anorectic signals provided by coinjection of CCK and leptin. Our findings give further insight into the mechanisms of feeding and energy balance. Copyright © 2014 the American Physiological Society.

  19. Deployment of a Testbed in a Brazilian Research Network using IPv6 and Optical Access Technologies

    Science.gov (United States)

    Martins, Luciano; Ferramola Pozzuto, João; Olimpio Tognolli, João; Chaves, Niudomar Siqueira De A.; Reggiani, Atilio Eduardo; Hortêncio, Claudio Antonio

    2012-04-01

    This article presents the implementation of a testbed and the experimental results obtained with it on the Brazilian Experimental Network of the government-sponsored "GIGA Project." The use of IPv6 integrated to current and emerging optical architectures and technologies, such as dense wavelength division multiplexing and 10-gigabit Ethernet on the core and gigabit capable passive optical network and optical distribution network on access, were tested. These protocols, architectures, and optical technologies are promising and part of a brand new worldwide technological scenario that has being fairly adopted in the networks of enterprises and providers of the world.

  20. On-line Configuration of Network Emulator for Intelligent Energy System Testbed Applications

    DEFF Research Database (Denmark)

    Kemal, Mohammed Seifu; Iov, Florin; Olsen, Rasmus Løvenstein

    2015-01-01

    interface for visualizing, configuring and monitoring of the emulated scenarios and a network socket linking the graphic server and network emulation server on-line. Specifically, our focus area is to build a model that gives us ability to look at some of the challenges on implementing inter...... a mechanism for on-line configuration and monitoring of heterogeneous communication technologies implemented at smart energy system testbed of Aal-borg university. It proposes a model with three main components, a network emulator used to emulate the communication scenarios using KauNet, graphical user...

  1. Performance Sensitivity Studies on the PIAA Implementation of the High-Contrast Imaging Testbed

    Science.gov (United States)

    Sidick, Erkin; Lou, John; Shaklan, Stuart; Levine, Marie

    2010-01-01

    This slide presentation reviews the sensitivity studies on the Phase-Induced Amplitude Apodization (PIAA), or pupil mapping using the High-Contrast Imaging Testbed (HCIT). PIAA is a promising technique in high-dynamic range stellar coronagraph. This presentation reports on the investigation of the effects of the phase and rigid-body errors of various optics on the narrowband contrast performance of the PIAA/HCIT hybrid system. The results have shown that the 2-step wavefront control method utilizing 2-DMs is quite effective in compensating the effects of realistic phase and rigid-body errors of various optics

  2. Test-bed Assessment of Communication Technologies for a Power-Balancing Controller

    DEFF Research Database (Denmark)

    Findrik, Mislav; Pedersen, Rasmus; Hasenleithner, Eduard

    2016-01-01

    and control. In this paper, we present a Smart Grid test-bed that integrates various communication technologies and deploys a power balancing controller for LV grids. Control performance of the introduced power balancing controller is subsequently investigated and its robustness to communication network cross......Due to growing need for sustainable energy, increasing number of different renewable energy resources are being connected into distribution grids. In order to efficiently manage a decentralized power generation units, the smart grid will rely on communication networks for information exchange......-traffic is evaluated. Various scenarios are demonstrated, assessing impact of communication network performance on quality of control....

  3. Application of the Semi-Empirical Force-Limiting Approach for the CoNNeCT SCAN Testbed

    Science.gov (United States)

    Staab, Lucas D.; McNelis, Mark E.; Akers, James C.; Suarez, Vicente J.; Jones, Trevor M.

    2012-01-01

    The semi-empirical force-limiting vibration method was developed and implemented for payload testing to limit the structural impedance mismatch (high force) that occurs during shaker vibration testing. The method has since been extended for use in analytical models. The Space Communications and Navigation Testbed (SCAN Testbed), known at NASA as, the Communications, Navigation, and Networking re-Configurable Testbed (CoNNeCT), project utilized force-limiting testing and analysis following the semi-empirical approach. This paper presents the steps in performing a force-limiting analysis and then compares the results to test data recovered during the CoNNeCT force-limiting random vibration qualification test that took place at NASA Glenn Research Center (GRC) in the Structural Dynamics Laboratory (SDL) December 19, 2010 to January 7, 2011. A compilation of lessons learned and considerations for future force-limiting tests is also included.

  4. Long Term Performance Metrics of the GD SDR on the SCaN Testbed: The First Year on the ISS

    Science.gov (United States)

    Nappier, Jennifer; Wilson, Molly C.

    2014-01-01

    The General Dynamics (GD) S-Band software defined radio (SDR) in the Space Communications and Navigation (SCaN) Testbed on the International Space Station (ISS) provides experimenters an opportunity to develop and demonstrate experimental waveforms in space. The SCaN Testbed was installed on the ISS in August of 2012. After installation, the initial checkout and commissioning phases were completed and experimental operations commenced. One goal of the SCaN Testbed is to collect long term performance metrics for SDRs operating in space in order to demonstrate long term reliability. These metrics include the time the SDR powered on, the time the power amplifier (PA) is powered on, temperature trends, error detection and correction (EDAC) behavior, and waveform operational usage time. This paper describes the performance of the GD SDR over the first year of operations on the ISS.

  5. High Frequency, Long Time Series Measurements from the Bermuda Testbed Mooring in Support of SIMBIOS. Chapter 8

    Science.gov (United States)

    Dickey, Tommy; Dobeck, Laura; Sigurdson, David; Zedler, Sarah; Manov, Derek; Yu, Xuri

    2001-01-01

    It has been recognized that optical moorings are important platforms for the validation of Sea-Viewing Wide Field-of-view Sensor (SeaWiFS). It was recommended that optical moorings be maintained in order to: (1) provide long-term time series comparisons between in situ and SeaWIFS measurements of normalized water-leaving radiance; (2) develop and test algorithms for pigment biomass and phytoplankton primary productivity; and (3) provide long-term, virtually continuous in situ observations which can be used to determine and optimize the accuracy of derived satellite products. These applications require the use of in situ radiometers for long periods of time to evaluate and correct for inherent satellite undersampling (aliasing and biasing) and degradation of satellite color sensors (e.g., drifts as experienced by the Coastal Zone Color Scanner). The Bermuda Testbed Mooring (BTM) program was initiated in 1994 at a site located about 80km southeast of Bermuda in waters of about 4530 m depth. In August 1997, with NASA's support, we started to provide the Sensor Intercomparison and Merger for Biological and Interdisciplinary Oceanic Studies (SIMBIOS) program with large volumes of high frequency, long-term time-series bio-optical data from the BTM for SeaWiFS satellite ocean color groundtruthing and algorithm development. This NASA supported portion of the BTM activity spanned three years and covered five BTM deployments. During these three years, the quality of radiometric data has improved dramatically. Excellent agreement between BTM moored data and both SeaWiFS and nearby ship profile radiometric data demonstrate that technical advances in the moored optical observations have reduced the major difficulties that moored platforms face: biofouling and less frequent calibration.

  6. Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial.

    Directory of Open Access Journals (Sweden)

    Steven F L van Lelyveld

    Full Text Available The immunomodulatory effects of the CCR5-antagonist maraviroc might be beneficial in patients with a suboptimal immunological response, but results of different cART (combination antiretroviral therapy intensification studies are conflicting. Therefore, we performed a 48-week placebo-controlled trial to determine the effect of maraviroc intensification on CD4+ T-cell counts and immune activation in these patients.Double-blind, placebo-controlled, randomized trial.Major inclusion criteria were 1. CD4+ T-cell count <350 cells/μL while at least two years on cART or CD4+ T-cell count <200 cells/μL while at least one year on cART, and 2. viral suppression for at least the previous 6 months. HIV-infected patients were randomized to add maraviroc (41 patients or placebo (44 patients to their cART regimen for 48 weeks. Changes in CD4+ T-cell counts (primary endpoint and other immunological parameters were modeled using linear mixed effects models.No significant differences for the modelled increase in CD4+ T-cell count (placebo 15.3 CD4+ T cells/μL (95% confidence interval (CI [1.0, 29.5] versus maraviroc arm 22.9 CD4+ T cells/μL (95% CI [7.4, 38.5] p = 0.51 or alterations in the expression of markers for T-cell activation, proliferation and microbial translocation were found between the arms. However, maraviroc intensification did increase the percentage of CCR5 expressing CD4+ and CD8+ T-cells, and the plasma levels of the CCR5 ligand MIP-1β. In contrast, the percentage of ex-vivo apoptotic CD8+ and CD4+ T-cells decreased in the maraviroc arm.Maraviroc intensification of cART did not increase CD4+ T-cell restoration or decrease immune activation as compared to placebo. However, ex-vivo T-cell apoptosis was decreased in the maraviroc arm.ClinicalTrials.gov NCT00875368.

  7. Optimizing Electric Vehicle Coordination Over a Heterogeneous Mesh Network in a Scaled-Down Smart Grid Testbed

    DEFF Research Database (Denmark)

    Bhattarai, Bishnu Prasad; Lévesque, Martin; Maier, Martin

    2015-01-01

    , smart grid (SG) is still at the developmental stage to address those issues. In this regard, a smart grid testbed (SGT) is desirable to develop, analyze, and demonstrate various novel SG solutions, namely demand response, real-time pricing, and congestion management. In this paper, a novel SGT...... is developed in a laboratory by scaling a 250 kVA, 0.4 kV real low-voltage distribution feeder down to 1 kVA, 0.22 kV. Information and communication technology is integrated in the scaled-down network to establish real-time monitoring and control. The novelty of the developed testbed is demonstrated...

  8. Design and Development of a 200-kW Turbo-Electric Distributed Propulsion Testbed

    Science.gov (United States)

    Papathakis, Kurt V.; Kloesel, Kurt J.; Lin, Yohan; Clarke, Sean; Ediger, Jacob J.; Ginn, Starr

    2016-01-01

    The National Aeronautics and Space Administration (NASA) Armstrong Flight Research Center (AFRC) (Edwards, California) is developing a Hybrid-Electric Integrated Systems Testbed (HEIST) Testbed as part of the HEIST Project, to study power management and transition complexities, modular architectures, and flight control laws for turbo-electric distributed propulsion technologies using representative hardware and piloted simulations. Capabilities are being developed to assess the flight readiness of hybrid electric and distributed electric vehicle architectures. Additionally, NASA will leverage experience gained and assets developed from HEIST to assist in flight-test proposal development, flight-test vehicle design, and evaluation of hybrid electric and distributed electric concept vehicles for flight safety. The HEIST test equipment will include three trailers supporting a distributed electric propulsion wing, a battery system and turbogenerator, dynamometers, and supporting power and communication infrastructure, all connected to the AFRC Core simulation. Plans call for 18 high performance electric motors that will be powered by batteries and the turbogenerator, and commanded by a piloted simulation. Flight control algorithms will be developed on the turbo-electric distributed propulsion system.

  9. The Objectives of NASA's Living with a Star Space Environment Testbed

    Science.gov (United States)

    Barth, Janet L.; LaBel, Kenneth A.; Brewer, Dana; Kauffman, Billy; Howard, Regan; Griffin, Geoff; Day, John H. (Technical Monitor)

    2001-01-01

    NASA is planning to fly a series of Space Environment Testbeds (SET) as part of the Living With A Star (LWS) Program. The goal of the testbeds is to improve and develop capabilities to mitigate and/or accommodate the affects of solar variability in spacecraft and avionics design and operation. This will be accomplished by performing technology validation in space to enable routine operations, characterize technology performance in space, and improve and develop models, guidelines and databases. The anticipated result of the LWS/SET program is improved spacecraft performance, design, and operation for survival of the radiation, spacecraft charging, meteoroid, orbital debris and thermosphere/ionosphere environments. The program calls for a series of NASA Research Announcements (NRAs) to be issued to solicit flight validation experiments, improvement in environment effects models and guidelines, and collateral environment measurements. The selected flight experiments may fly on the SET experiment carriers and flights of opportunity on other commercial and technology missions. This paper presents the status of the project so far, including a description of the types of experiments that are intended to fly on SET-1 and a description of the SET-1 carrier parameters.

  10. Carrier Plus: A sensor payload for Living With a Star Space Environment Testbed (LWS/SET)

    Science.gov (United States)

    Marshall, Cheryl J.; Moss, Steven; Howard, Regan; LaBel, Kenneth A.; Grycewicz, Tom; Barth, Janet L.; Brewer, Dana

    2003-01-01

    The Defense Threat Reduction Agency (DTR4) and National Aeronautics and Space Administration (NASA) Goddard Space Flight Center are collaborating to develop the Carrier Plus sensor experiment platform as a capability of the Space Environments Testbed (SET). The Space Environment Testbed (SET) provides flight opportunities for technology experiments as part of NASA's Living With a Star (LWS) program. The Carrier Plus will provide new capability to characterize sensor technologies such as state-of-the-art visible focal plane arrays (FPAs) in a natural space radiation environment. The technical objectives include on-orbit validation of recently developed FPA technologies and performance prediction methodologies, as well as characterization of the FPA radiation response to total ionizing dose damage, displacement damage and transients. It is expected that the sensor experiment will carry 4-6 FPAs and associated radiation correlative environment monitors (CEMs) for a 2006-2007 launch. Sensor technology candidates may include n- and p-charge coupled devices (CCDs), active pixel sensors (APS), and hybrid CMOS arrays. The presentation will describe the Carrier Plus goals and objectives, as well as provide details about the architecture and design. More information on the LWS program can be found at http://lws.gsfc.nasa.gov/. Business announcements for LWS/SET and program briefings are posted at http://lws-set.gsfc.nasa.gov

  11. An Integrated Testbed for Cooperative Perception with Heterogeneous Mobile and Static Sensors

    Directory of Open Access Journals (Sweden)

    Aníbal Ollero

    2011-12-01

    Full Text Available Cooperation among devices with different sensing, computing and communication capabilities provides interesting possibilities in a growing number of problems and applications including domotics (domestic robotics, environmental monitoring or intelligent cities, among others. Despite the increasing interest in academic and industrial communities, experimental tools for evaluation and comparison of cooperative algorithms for such heterogeneous technologies are still very scarce. This paper presents a remote testbed with mobile robots and Wireless Sensor Networks (WSN equipped with a set of low-cost off-the-shelf sensors, commonly used in cooperative perception research and applications, that present high degree of heterogeneity in their technology, sensed magnitudes, features, output bandwidth, interfaces and power consumption, among others. Its open and modular architecture allows tight integration and interoperability between mobile robots and WSN through a bidirectional protocol that enables full interaction. Moreover, the integration of standard tools and interfaces increases usability, allowing an easy extension to new hardware and software components and the reuse of code. Different levels of decentralization are considered, supporting from totally distributed to centralized approaches. Developed for the EU-funded Cooperating Objects Network of Excellence (CONET and currently available at the School of Engineering of Seville (Spain, the testbed provides full remote control through the Internet. Numerous experiments have been performed, some of which are described in the paper.

  12. Investigation of Asymmetric Thrust Detection with Demonstration in a Real-Time Simulation Testbed

    Science.gov (United States)

    Chicatelli, Amy K.; Rinehart, Aidan W.; Sowers, T. Shane; Simon, Donald L.

    2016-01-01

    The purpose of this effort is to develop, demonstrate, and evaluate three asymmetric thrust detection approaches to aid in the reduction of asymmetric thrust-induced aviation accidents. This paper presents the results from that effort and their evaluation in simulation studies, including those from a real-time flight simulation testbed. Asymmetric thrust is recognized as a contributing factor in several Propulsion System Malfunction plus Inappropriate Crew Response (PSM+ICR) aviation accidents. As an improvement over the state-of-the-art, providing annunciation of asymmetric thrust to alert the crew may hold safety benefits. For this, the reliable detection and confirmation of asymmetric thrust conditions is required. For this work, three asymmetric thrust detection methods are presented along with their results obtained through simulation studies. Representative asymmetric thrust conditions are modeled in simulation based on failure scenarios similar to those reported in aviation incident and accident descriptions. These simulated asymmetric thrust scenarios, combined with actual aircraft operational flight data, are then used to conduct a sensitivity study regarding the detection capabilities of the three methods. Additional evaluation results are presented based on pilot-in-the-loop simulation studies conducted in the NASA Glenn Research Center (GRC) flight simulation testbed. Data obtained from this flight simulation facility are used to further evaluate the effectiveness and accuracy of the asymmetric thrust detection approaches. Generally, the asymmetric thrust conditions are correctly detected and confirmed.

  13. A Functional Neuroimaging Analysis of the Trail Making Test-B: Implications for Clinical Application

    Directory of Open Access Journals (Sweden)

    Mark D. Allen

    2011-01-01

    Full Text Available Recent progress has been made using fMRI as a clinical assessment tool, often employing analogues of traditional “paper and pencil” tests. The Trail Making Test (TMT, popular for years as a neuropsychological exam, has been largely ignored in the realm of neuroimaging, most likely because its physical format and administration does not lend itself to straightforward adaptation as an fMRI paradigm. Likewise, there is relatively more ambiguity about the neural systems associated with this test than many other tests of comparable clinical use. In this study, we describe an fMRI version of Trail Making Test-B (TMTB that maintains the core functionality of the TMT while optimizing its use for both research and clinical settings. Subjects (N = 32 were administered the Functional Trail Making Test-B (f-TMTB. Brain region activations elicited by the f-TMTB were consistent with expectations given by prior TMT neurophysiological studies, including significant activations in the ventral and dorsal visual pathways and the medial pre-supplementary motor area. The f-TMTB was further evaluated for concurrent validity with the traditional TMTB using an additional sample of control subjects (N = 100. Together, these results support the f-TMTB as a viable neuroimaging adaptation of the TMT that is optimized to evoke maximally robust fMRI activation with minimal time and equipment requirements.

  14. A low-cost test-bed for real-time landmark tracking

    Science.gov (United States)

    Csaszar, Ambrus; Hanan, Jay C.; Moreels, Pierre; Assad, Christopher

    2007-04-01

    A low-cost vehicle test-bed system was developed to iteratively test, refine and demonstrate navigation algorithms before attempting to transfer the algorithms to more advanced rover prototypes. The platform used here was a modified radio controlled (RC) car. A microcontroller board and onboard laptop computer allow for either autonomous or remote operation via a computer workstation. The sensors onboard the vehicle represent the types currently used on NASA-JPL rover prototypes. For dead-reckoning navigation, optical wheel encoders, a single axis gyroscope, and 2-axis accelerometer were used. An ultrasound ranger is available to calculate distance as a substitute for the stereo vision systems presently used on rovers. The prototype also carries a small laptop computer with a USB camera and wireless transmitter to send real time video to an off-board computer. A real-time user interface was implemented that combines an automatic image feature selector, tracking parameter controls, streaming video viewer, and user generated or autonomous driving commands. Using the test-bed, real-time landmark tracking was demonstrated by autonomously driving the vehicle through the JPL Mars yard. The algorithms tracked rocks as waypoints. This generated coordinates calculating relative motion and visually servoing to science targets. A limitation for the current system is serial computing-each additional landmark is tracked in order-but since each landmark is tracked independently, if transferred to appropriate parallel hardware, adding targets would not significantly diminish system speed.

  15. Adaptive Coding and Modulation Experiment With NASA's Space Communication and Navigation Testbed

    Science.gov (United States)

    Downey, Joseph; Mortensen, Dale; Evans, Michael; Briones, Janette; Tollis, Nicholas

    2016-01-01

    National Aeronautics and Space Administration (NASA)'s Space Communication and Navigation Testbed is an advanced integrated communication payload on the International Space Station. This paper presents results from an adaptive coding and modulation (ACM) experiment over S-band using a direct-to-earth link between the SCaN Testbed and the Glenn Research Center. The testing leverages the established Digital Video Broadcasting Second Generation (DVB-S2) standard to provide various modulation and coding options, and uses the Space Data Link Protocol (Consultative Committee for Space Data Systems (CCSDS) standard) for the uplink and downlink data framing. The experiment was conducted in a challenging environment due to the multipath and shadowing caused by the International Space Station structure. Several approaches for improving the ACM system are presented, including predictive and learning techniques to accommodate signal fades. Performance of the system is evaluated as a function of end-to-end system latency (round-trip delay), and compared to the capacity of the link. Finally, improvements over standard NASA waveforms are presented.

  16. The Orlando TDWR testbed and airborne wind shear date comparison results

    Science.gov (United States)

    Campbell, Steven; Berke, Anthony; Matthews, Michael

    1992-01-01

    The focus of this talk is on comparing terminal Doppler Weather Radar (TDWR) and airborne wind shear data in computing a microburst hazard index called the F factor. The TDWR is a ground-based system for detecting wind shear hazards to aviation in the terminal area. The Federal Aviation Administration will begin deploying TDWR units near 45 airports in late 1992. As part of this development effort, M.I.T. Lincoln Laboratory operates under F.A.A. support a TDWR testbed radar in Orlando, FL. During the past two years, a series of flight tests has been conducted with instrumented aircraft penetrating microburst events while under testbed radar surveillance. These tests were carried out with a Cessna Citation 2 aircraft operated by the University of North Dakota (UND) Center for Aerospace Sciences in 1990, and a Boeing 737 operated by NASA Langley Research Center in 1991. A large data base of approximately 60 instrumented microburst penetrations has been obtained from these flights.

  17. An integrated testbed for cooperative perception with heterogeneous mobile and static sensors.

    Science.gov (United States)

    Jiménez-González, Adrián; Martínez-De Dios, José Ramiro; Ollero, Aníbal

    2011-01-01

    Cooperation among devices with different sensing, computing and communication capabilities provides interesting possibilities in a growing number of problems and applications including domotics (domestic robotics), environmental monitoring or intelligent cities, among others. Despite the increasing interest in academic and industrial communities, experimental tools for evaluation and comparison of cooperative algorithms for such heterogeneous technologies are still very scarce. This paper presents a remote testbed with mobile robots and Wireless Sensor Networks (WSN) equipped with a set of low-cost off-the-shelf sensors, commonly used in cooperative perception research and applications, that present high degree of heterogeneity in their technology, sensed magnitudes, features, output bandwidth, interfaces and power consumption, among others. Its open and modular architecture allows tight integration and interoperability between mobile robots and WSN through a bidirectional protocol that enables full interaction. Moreover, the integration of standard tools and interfaces increases usability, allowing an easy extension to new hardware and software components and the reuse of code. Different levels of decentralization are considered, supporting from totally distributed to centralized approaches. Developed for the EU-funded Cooperating Objects Network of Excellence (CONET) and currently available at the School of Engineering of Seville (Spain), the testbed provides full remote control through the Internet. Numerous experiments have been performed, some of which are described in the paper.

  18. An Integrated Testbed for Cooperative Perception with Heterogeneous Mobile and Static Sensors

    Science.gov (United States)

    Jiménez-González, Adrián; Martínez-De Dios, José Ramiro; Ollero, Aníbal

    2011-01-01

    Cooperation among devices with different sensing, computing and communication capabilities provides interesting possibilities in a growing number of problems and applications including domotics (domestic robotics), environmental monitoring or intelligent cities, among others. Despite the increasing interest in academic and industrial communities, experimental tools for evaluation and comparison of cooperative algorithms for such heterogeneous technologies are still very scarce. This paper presents a remote testbed with mobile robots and Wireless Sensor Networks (WSN) equipped with a set of low-cost off-the-shelf sensors, commonly used in cooperative perception research and applications, that present high degree of heterogeneity in their technology, sensed magnitudes, features, output bandwidth, interfaces and power consumption, among others. Its open and modular architecture allows tight integration and interoperability between mobile robots and WSN through a bidirectional protocol that enables full interaction. Moreover, the integration of standard tools and interfaces increases usability, allowing an easy extension to new hardware and software components and the reuse of code. Different levels of decentralization are considered, supporting from totally distributed to centralized approaches. Developed for the EU-funded Cooperating Objects Network of Excellence (CONET) and currently available at the School of Engineering of Seville (Spain), the testbed provides full remote control through the Internet. Numerous experiments have been performed, some of which are described in the paper. PMID:22247679

  19. Open-Source Based Testbed for Multioperator 4G/5G Infrastructure Sharing in Virtual Environments

    Directory of Open Access Journals (Sweden)

    Ricardo Marco Alaez

    2017-01-01

    Full Text Available Fourth-Generation (4G mobile networks are based on Long-Term Evolution (LTE technologies and are being deployed worldwide, while research on further evolution towards the Fifth Generation (5G has been recently initiated. 5G will be featured with advanced network infrastructure sharing capabilities among different operators. Therefore, an open-source implementation of 4G/5G networks with this capability is crucial to enable early research in this area. The main contribution of this paper is the design and implementation of such a 4G/5G open-source testbed to investigate multioperator infrastructure sharing capabilities executed in virtual architectures. The proposed design and implementation enable the virtualization and sharing of some of the components of the LTE architecture. A testbed has been implemented and validated with intensive empirical experiments conducted to validate the suitability of virtualizing LTE components in virtual infrastructures (i.e., infrastructures with multitenancy sharing capabilities. The impact of the proposed technologies can lead to significant saving of both capital and operational costs for mobile telecommunication operators.

  20. Current Status of the High Contrast Imager for Complex Aperture Telescopes (HiCAT) Testbed

    Science.gov (United States)

    Brooks, Keira; Brady, Gregory; Brito, Arturo; Comeau, Tom; Dillon, Thomas; Choquet, Elodie; Egron, Sylvain; Rob, Gontrum; John, Hagopian; Leboulleux, Lucie; Perrin, Marshall; Petrone, Peter; Pueyo, Laurent; Mazoyer, Johan; Moriarty, Christopher; N’Diaye, Mamadou; Eldorado Riggs, A. J.; Shiri, Ron; Sivaramakrishnan, Anand; St. Laurent, Kathryn; Valenzuela, Ana Maria; Zimmerman, Neil; Soummer, Remi; JHU Mechanical Engineering Senior Design Team

    2018-01-01

    The coming decades will bring the next space telescopes to take on the ambitious goal of exoplanet discovery via direct imaging, driving the development of innovative coronagraphic solutions. High contrast imager for Complex Aperture Telescopes (HiCAT) is an optical testbed meant to test such solutions for complex aperture telescopes, such as the Large UV/Optical/InfraRed surveyor (LUVOIR), or any other segmented space observatory. High contrast imaging becomes more demanding with the addition of segments, a secondary mirror obscuration, and support structure. LUVOIR, a candidate for the next-next generation major space telescope funded in part by NASA, will have all three. In the past year, HiCAT has made significant hardware and software updates in order to meet the needs of LUVOIR. In addition to completely overhauling the software that runs the testbed, we have received the first two custom-made apodizers for the Apodized Pupil Lyot Coronagraph (APLC) that we are testing for LUVOIR, and are continuing the development of the wavefront sensing and control. This poster will serve to give an update on these, and other, changes, as well as the most recent results.

  1. Investigations Using Laboratory Testbeds to Interpret Flight Instrument Datasets from Mars Robotic Missions

    Science.gov (United States)

    Ming, D. W.; Morris, R. V.; Sutter, B.; Archer, P. D., Jr.; Achilles, C. N.

    2012-01-01

    The Astromaterials Research and Exploration Science Directorate at the NASA Johnson Space Center (JSC) has laboratory instrumentation that mimic the capabilities of corresponding flight instruments to enable interpretation of datasets returned from Mars robotic missions. The lab instruments have been and continue to be applied to datasets for the Moessbauer Spectrometer (MB) on the Mars Exploration Rovers (MER), the Thermal & Evolved Gas Analyzer (TEGA) on the Mars Phoenix Scout, the CRISM instrument on the Mars Reconnaissance Orbiter Missions and will be applied to datasets for the Sample Analysis at Mars (SAM), Chemistry and Mineralogy (CheMin) and Chemistry & Camera (ChemCam) instruments onboard the Mars Science Laboratory (MSL). The laboratory instruments can analyze analog samples at costs that are substantially lower than engineering models of flight instruments, but their success to enable interpretation of flight data depends on how closely their capabilities mimic those of the flight instrument. The JSC lab MB instruments are equivalent to the MER instruments except without flight qualified components and no reference channel Co-57 source. Data from analog samples were critical for identification of Mg-Fe carbonate at Gusev crater. Fiber-optic VNIR spectrometers are used to obtain CRISM-like spectral data over the range 350-2500 nm, and data for Fephyllosilicates show irreversible behavior in the electronic transition region upon dessication. The MB and VNIR instruments can be operated within chambers where, for example, the absolute H2O concentration can be measured and controlled. Phoenix's TEGA consisted of a calorimeter coupled to a mass spectrometer (MS). The JSC laboratory testbed instrument consisted of a differential scanning calorimeter (DSC) coupled to a MS configured to operate under total pressure (12 mbar), heating rate (20 C/min), and purge gas composition (N2) analogous to the flight TEGA. TEGA detected CO2 release at both low (400-680 C

  2. [New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "à la carte" treatment?].

    Science.gov (United States)

    Dreyer, Chantal; Afchain, Pauline; Trouilloud, Isabelle; André, Thierry

    2016-01-01

    This review reports 3 of recently published molecular classifications of the 3 main gastro-intestinal cancers: gastric, pancreatic and colorectal adenocarcinoma. In colorectal adenocarcinoma, 6 independent classifications were combined to finally hold 4 molecular sub-groups, Consensus Molecular Subtypes (CMS 1-4), linked to various clinical, molecular and survival data. CMS1 (14% MSI with immune activation); CMS2 (37%: canonical with epithelial differentiation and activation of the WNT/MYC pathway); CMS3 (13% metabolic with epithelial differentiation and RAS mutation); CMS4 (23%: mesenchymal with activation of TGFβ pathway and angiogenesis with stromal invasion). In gastric adenocarcinoma, 4 groups were established: subtype "EBV" (9%, high frequency of PIK3CA mutations, hypermetylation and amplification of JAK2, PD-L1 and PD-L2), subtype "MSI" (22%, high rate of mutation), subtype "genomically stable tumor" (20%, diffuse histology type and mutations of RAS and genes encoding integrins and adhesion proteins including CDH1) and subtype "tumors with chromosomal instability" (50%, intestinal type, aneuploidy and receptor tyrosine kinase amplification). In pancreatic adenocarcinomas, a classification in four sub-groups has been proposed, stable subtype (20%, aneuploidy), locally rearranged subtype (30%, focal event on one or two chromosoms), scattered subtype (36%,200 structural variation events, defects in DNA maintenance). Although currently away from the care of patients, these classifications open the way to "à la carte" treatment depending on molecular biology. Copyright © 2016 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  3. Anti-CD123 chimeric antigen receptor T-cells (CART): an evolving treatment strategy for hematological malignancies, and a potential ace-in-the-hole against antigen-negative relapse.

    Science.gov (United States)

    Cummins, Katherine D; Gill, Saar

    2017-09-13

    Chimeric antigen receptor-modified T-cells (CART) are a potent and targeted immunotherapy which have induced remissions in some patients with chemotherapy refractory or relapsed (RR) hematologic malignancies. Hundreds of patients have now been treated worldwide with anti-CD19 CART cells, with complete response rates of up to 90%. CART therapy has a unique toxicity profile, and unfortunately not all responses are durable. Treatment failure occurs via two main routes - by loss of the CART cell population, or relapse with antigen loss. Emerging data indicate that targeting an alternative antigen instead of, or as well as CD19, could improve CART cell efficacy and reduce antigen-negative relapse. Other strategies include the addition of other immune-based therapies. This review explores the rationale, pre-clinical data and currently investigative strategies underway for CART therapy targeting the myeloid and lymphoid stem/progenitor antigen CD123.

  4. Building a ROS-Based Testbed for Realistic Multi-Robot Simulation: Taking the Exploration as an Example

    Directory of Open Access Journals (Sweden)

    Zhi Yan

    2017-09-01

    Full Text Available While the robotics community agrees that the benchmarking is of high importance to objectively compare different solutions, there are only few and limited tools to support it. To address this issue in the context of multi-robot systems, we have defined a benchmarking process based on experimental designs, which aimed at improving the reproducibility of experiments by making explicit all elements of a benchmark such as parameters, measurements and metrics. We have also developed a ROS (Robot Operating System-based testbed with the goal of making it easy for users to validate, benchmark, and compare different algorithms including coordination strategies. Our testbed uses the MORSE (Modular OpenRobots Simulation Engine simulator for realistic simulation and a computer cluster for decentralized computation. In this paper, we present our testbed in details with the architecture and infrastructure, the issues encountered in implementing the infrastructure, and the automation of the deployment. We also report a series of experiments on multi-robot exploration, in order to demonstrate the capabilities of our testbed.

  5. MSFC Robotic Lunar Lander Testbed and Current Status of the International Lunar Network (ILN) Anchor Nodes Mission

    Science.gov (United States)

    Cohen, Barbara; Bassler, Julie; Harris, Danny; Morse, Brian; Reed, Cheryl; Kirby, Karen; Eng, Douglas

    2009-01-01

    The lunar lander robotic exploration testbed at Marshall Spaceflight Center provides a test environment for robotic lander test articles, components and algorithms to reduce the risk on the airless body designs during lunar landing. Also included is a chart comparing the two different types of Anchor nodes for the International Lunar Network (ILN): Solar/Battery and the Advanced Stirling Radioisotope generator (ARSG.)

  6. The WorldGrid transatlantic testbed: a successful example of Grid interoperability across EU and U.S. domains

    CERN Document Server

    Donno, F; Rebatto, D; Vaccarossa, L; Verlato, M; Donno, Flavia; Ciaschini, Vincenzo; Rebatto, David; Vaccarossa, Luca; Verlato, Marco

    2003-01-01

    The European DataTAG project has taken a major step towards making the concept of a worldwide computing Grid a reality. In collaboration with the companion U.S. project iVDGL, DataTAG has realized an intercontinental testbed spanning Europe and the U.S. integrating architecturally different Grid implementations based on the Globus toolkit. The WorldGrid testbed has been successfully demonstrated at SuperComputing 2002 and IST2002 where real HEP application jobs were transparently submitted from U.S. and Europe using native mechanisms and run where resources were available, independently of their location. In this paper we describe the architecture of the WorldGrid testbed, the problems encountered and the solutions taken in realizing such a testbed. With our work we present an important step towards interoperability of Grid middleware developed and deployed in Europe and the U.S.. Some of the solutions developed in WorldGrid will be adopted by the LHC Computing Grid first service. To the best of our knowledge...

  7. Photovoltaic Engineering Testbed: A Facility for Space Calibration and Measurement of Solar Cells on the International Space Station

    Science.gov (United States)

    Landis, Geoffrey A.; Bailey, Sheila G.; Jenkins, Phillip; Sexton, J. Andrew; Scheiman, David; Christie, Robert; Charpie, James; Gerber, Scott S.; Johnson, D. Bruce

    2001-01-01

    The Photovoltaic Engineering Testbed ("PET") is a facility to be flown on the International Space Station to perform calibration, measurement, and qualification of solar cells in the space environment and then returning the cells to Earth for laboratory use. PET will allow rapid turnaround testing of new photovoltaic technology under AM0 conditions.

  8. Dynamic virtual GMPLS-controlled WSON using a Resource Broker with a VNT Manager on the ADRENALINE testbed.

    Science.gov (United States)

    Vilalta, Ricard; Muñoz, Raul; Casellas, Ramon; Martinez, Ricardo

    2012-12-31

    We present a Resource Broker with a Virtual Network Topology Manager (VNTM) which dynamically deploys virtual GMPLS-controlled WSON networks. Virtual Optical links are constructed by grouping established optical connections which are managed by the VNTM. We evaluate the performance of the Resource Broker in the ADRENALINE testbed.

  9. First light of an external occulter testbed at flight Fresnel numbers

    Science.gov (United States)

    Kim, Yunjong; Sirbu, Dan; Hu, Mia; Kasdin, Jeremy; Vanderbei, Robert J.; Harness, Anthony; Shaklan, Stuart

    2017-01-01

    Many approaches have been suggested over the last couple of decades for imaging Earth-like planets. One of the main candidates for creating high-contrast for future Earth-like planets detection is an external occulter. The external occulter is a spacecraft flown along the line-of-sight of a space telescope to suppress starlight and enable high-contrast direct imaging of exoplanets. The occulter is typically tens of meters in diameter and the separation from the telescope is of the order of tens of thousands of kilometers. Optical testing of a full-scale external occulter on the ground is impossible because of the long separations. Therefore, laboratory verification of occulter designs is necessary to validate the optical models used to design and predict occulter performance. At Princeton, we have designed and built a testbed that allows verification of scaled occulter designs whose suppressed shadow is mathematically identical to that of space occulters. The goal of this experiment is to demonstrate a pupil plane suppression of better than 1e-9 with a corresponding image plane contrast of better than 1e-11. The occulter testbed uses a 77.2 m optical propagation distance to realize the flight Fresnel number of 14.5. The scaled mask is placed at 27.2 m from the artificial source and the camera is located 50.0 m from the scaled mask. We will use an etched silicon mask, manufactured by the Microdevices Lab(MDL) of the Jet Propulsion Laboratory(JPL), as the occulter. Based on conversations with MDL, we expect that 0.5 μm feature size is an achievable resolution in the mask manufacturing process and is therefore likely the indicator of the best possible performance. The occulter is illuminated by a diverging laser beam to reduce the aberrations from the optics before the occulter. Here, we present first light result of a sample design operating at a flight Fresnel number and the experimental setup of the testbed. We compare the experimental results with simulations

  10. Recent Successes and Future Plans for NASA's Space Communications and Navigation Testbed on the International Space Station

    Science.gov (United States)

    Reinhart, Richard C.; Sankovic, John M.; Johnson, Sandra K.; Lux, James P.; Chelmins, David T.

    2014-01-01

    Flexible and extensible space communications architectures and technology are essential to enable future space exploration and science activities. NASA has championed the development of the Space Telecommunications Radio System (STRS) software defined radio (SDR) standard and the application of SDR technology to reduce the costs and risks of using SDRs for space missions, and has developed an on-orbit testbed to validate these capabilities. The Space Communications and Navigation (SCaN) Testbed (previously known as the Communications, Navigation, and Networking reConfigurable Testbed (CoNNeCT)) is advancing SDR, on-board networking, and navigation technologies by conducting space experiments aboard the International Space Station. During its first year(s) on-orbit, the SCaN Testbed has achieved considerable accomplishments to better understand SDRs and their applications. The SDR platforms and software waveforms on each SDR have over 1500 hours of operation and are performing as designed. The Ka-band SDR on the SCaN Testbed is NASAs first space Ka-band transceiver and is NASA's first Ka-band mission using the Space Network. This has provided exciting opportunities to operate at Ka-band and assist with on-orbit tests of NASA newest Tracking and Data Relay Satellites (TDRS). During its first year, SCaN Testbed completed its first on-orbit SDR reconfigurations. SDR reconfigurations occur when implementing new waveforms on an SDR. SDR reconfigurations allow a radio to change minor parameters, such as data rate, or complete functionality. New waveforms which provide new capability and are reusable across different missions provide long term value for reconfigurable platforms such as SDRs. The STRS Standard provides guidelines for new waveform development by third parties. Waveform development by organizations other than the platform provider offers NASA the ability to develop waveforms itself and reduce its dependence and costs on the platform developer. Each of these

  11. A Hybrid PCA-CART-MARS-Based Prognostic Approach of the Remaining Useful Life for Aircraft Engines

    Directory of Open Access Journals (Sweden)

    Fernando Sánchez Lasheras

    2015-03-01

    Full Text Available Prognostics is an engineering discipline that predicts the future health of a system. In this research work, a data-driven approach for prognostics is proposed. Indeed, the present paper describes a data-driven hybrid model for the successful prediction of the remaining useful life of aircraft engines. The approach combines the multivariate adaptive regression splines (MARS technique with the principal component analysis (PCA, dendrograms and classification and regression trees (CARTs. Elements extracted from sensor signals are used to train this hybrid model, representing different levels of health for aircraft engines. In this way, this hybrid algorithm is used to predict the trends of these elements. Based on this fitting, one can determine the future health state of a system and estimate its remaining useful life (RUL with accuracy. To evaluate the proposed approach, a test was carried out using aircraft engine signals collected from physical sensors (temperature, pressure, speed, fuel flow, etc.. Simulation results show that the PCA-CART-MARS-based approach can forecast faults long before they occur and can predict the RUL. The proposed hybrid model presents as its main advantage the fact that it does not require information about the previous operation states of the input variables of the engine. The performance of this model was compared with those obtained by other benchmark models (multivariate linear regression and artificial neural networks also applied in recent years for the modeling of remaining useful life. Therefore, the PCA-CART-MARS-based approach is very promising in the field of prognostics of the RUL for aircraft engines.

  12. Genetic polymorphisms associated with fatty liver disease and fibrosis in HIV positive patients receiving combined antiretroviral therapy (cART).

    Science.gov (United States)

    Dold, Leona; Luda, Carolin; Schwarze-Zander, Carolynne; Boesecke, Christoph; Hansel, Cordula; Nischalke, Hans-Dieter; Lutz, Philipp; Mohr, Raphael; Wasmuth, Jan-Christian; Strassburg, Christian P; Trebicka, Jonel; Rockstroh, Jürgen Kurt; Spengler, Ulrich

    2017-01-01

    Hepatic steatosis can occur with any antiretroviral therapy (cART). Although single nucleotide polymorphisms (SNPs) have been identified to predispose to alcoholic and non-alcoholic fatty liver disease, their role for treatment-associated steatosis in HIV-positive patients remains unclear. We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), PPP1R3B (rs4240624), TM6SF (rs8542926), LYPLAL1 (rs12137855) and MBOAT7 (rs626283) by RT-PCR in 117 HIV-positive patients on cART and stratified participants based on their "controlled attenuation parameter" (CAP) into probable (CAP: 215-300 dB/m) and definite (CAP >300 dB/m) hepatic steatosis. We analyzed CAP values and routine metabolic parameters according to the allele frequencies. Sixty-five (55.6%) and 13 (11.1%) patients were allocated to probable and definite steatosis. CAP values (p = 0.012) and serum triglycerides (p = 0.043) were increased in carriers of the GCKR (rs780094) A allele. Cox logistic regression identified triglycerides (p = 0.006), bilirubin (p = 0.021) and BMI (p = 0.068), but not the genetic parameters as risk factors for the occurrence of hepatic steatosis. Taken together, according to the limited sample size, this exploratory study generates the hypothesis that genetic polymorphisms seem to exert minor effects on the risk for fatty liver disease in HIV-positive patients on cART. Nevertheless, SNPs may modify metabolic complications once metabolic abnormalities have developed. Hence, subsequent analysis of a larger cohort is needed.

  13. Intermittent Feedback-Control Strategy for Stabilizing Inverted Pendulum on Manually Controlled Cart as Analogy to Human Stick Balancing.

    Science.gov (United States)

    Yoshikawa, Naoya; Suzuki, Yasuyuki; Kiyono, Ken; Nomura, Taishin

    2016-01-01

    The stabilization of an inverted pendulum on a manually controlled cart (cart-inverted-pendulum; CIP) in an upright position, which is analogous to balancing a stick on a fingertip, is considered in order to investigate how the human central nervous system (CNS) stabilizes unstable dynamics due to mechanical instability and time delays in neural feedback control. We explore the possibility that a type of intermittent time-delayed feedback control, which has been proposed for human postural control during quiet standing, is also a promising strategy for the CIP task and stick balancing on a fingertip. Such a strategy hypothesizes that the CNS exploits transient contracting dynamics along a stable manifold of a saddle-type unstable upright equilibrium of the inverted pendulum in the absence of control by inactivating neural feedback control intermittently for compensating delay-induced instability. To this end, the motions of a CIP stabilized by human subjects were experimentally acquired, and computational models of the system were employed to characterize the experimental behaviors. We first confirmed fat-tailed non-Gaussian temporal fluctuation in the acceleration distribution of the pendulum, as well as the power-law distributions of corrective cart movements for skilled subjects, which was previously reported for stick balancing. We then showed that the experimental behaviors could be better described by the models with an intermittent delayed feedback controller than by those with the conventional continuous delayed feedback controller, suggesting that the human CNS stabilizes the upright posture of the pendulum by utilizing the intermittent delayed feedback-control strategy.

  14. Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons

    Science.gov (United States)

    Sousa-Ferreira, Lígia; Álvaro, Ana Rita; Aveleira, Célia; Santana, Magda; Brandão, Inês; Kügler, Sebastian; Pereira de Almeida, Luís; Cavadas, Cláudia

    2011-01-01

    Some pathological conditions with feeding pattern alterations, including obesity and Huntington disease (HD) are associated with hypothalamic dysfunction and neuronal cell death. Additionally, the hypothalamus is a neurogenic region with the constitutive capacity to generate new cells of neuronal lineage, in adult rodents. The aim of the present work was to evaluate the expression of feeding-related neuropeptides in hypothalamic progenitor cells and their capacity to differentiate to functional neurons which have been described to be affected by hypothalamic dysfunction. Our study shows that hypothalamic progenitor cells from rat embryos grow as floating neurospheres and express the feeding-related neuropeptides Neuropeptide Y (NPY), Agouti-related Protein (AGRP), Pro-OpioMelanocortin (POMC), Cocaine-and-Amphetamine Responsive Transcript (CART) and Orexin-A/Hypocretin-1. Moreover the relative mRNA expression of NPY and POMC increases during the expansion of hypothalamic neurospheres in proliferative conditions. Mature neurons were obtained from the differentiation of hypothalamic progenitor cells including NPY, AGRP, POMC, CART and Orexin-A positive neurons. Furthermore the relative mRNA expression of NPY, CART and Orexin-A increases after the differentiation of hypothalamic neurospheres. Similarly to the adult hypothalamic neurons the neurospheres-derived neurons express the glutamate transporter EAAT3. The orexigenic and anorexigenic phenotype of these neurons was identified by functional response to ghrelin and leptin hormones, respectively. This work demonstrates the presence of appetite-related neuropeptides in hypothalamic progenitor cells and neurons obtained from the differentiation of hypothalamic neurospheres, including the neuronal phenotypes that have been described by others as being affected by hypothalamic neurodegeneration. These in vitro models can be used to study hypothalamic progenitor cells aiming a therapeutic intervention to mitigate feeding

  15. Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.

    Directory of Open Access Journals (Sweden)

    Lígia Sousa-Ferreira

    Full Text Available Some pathological conditions with feeding pattern alterations, including obesity and Huntington disease (HD are associated with hypothalamic dysfunction and neuronal cell death. Additionally, the hypothalamus is a neurogenic region with the constitutive capacity to generate new cells of neuronal lineage, in adult rodents. The aim of the present work was to evaluate the expression of feeding-related neuropeptides in hypothalamic progenitor cells and their capacity to differentiate to functional neurons which have been described to be affected by hypothalamic dysfunction. Our study shows that hypothalamic progenitor cells from rat embryos grow as floating neurospheres and express the feeding-related neuropeptides Neuropeptide Y (NPY, Agouti-related Protein (AGRP, Pro-OpioMelanocortin (POMC, Cocaine-and-Amphetamine Responsive Transcript (CART and Orexin-A/Hypocretin-1. Moreover the relative mRNA expression of NPY and POMC increases during the expansion of hypothalamic neurospheres in proliferative conditions.Mature neurons were obtained from the differentiation of hypothalamic progenitor cells including NPY, AGRP, POMC, CART and Orexin-A positive neurons. Furthermore the relative mRNA expression of NPY, CART and Orexin-A increases after the differentiation of hypothalamic neurospheres. Similarly to the adult hypothalamic neurons the neurospheres-derived neurons express the glutamate transporter EAAT3. The orexigenic and anorexigenic phenotype of these neurons was identified by functional response to ghrelin and leptin hormones, respectively. This work demonstrates the presence of appetite-related neuropeptides in hypothalamic progenitor cells and neurons obtained from the differentiation of hypothalamic neurospheres, including the neuronal phenotypes that have been described by others as being affected by hypothalamic neurodegeneration. These in vitro models can be used to study hypothalamic progenitor cells aiming a therapeutic intervention to

  16. Un processus automatique d’amélioration des contrastes colorés sur les cartes de risques

    Directory of Open Access Journals (Sweden)

    Élisabeth Chesneau

    2009-12-01

    Full Text Available Sur les cartes de risques, la densité et la superposition des signes rendent la lecture et la compréhension des informations parfois difficiles. Pour améliorer cette lisibilité, il a semblé pertinent de jouer sur les couleurs, précisément leurs contrastes: un modèle d’analyse et d'amélioration automatiques des contrastes colorés a été développé dans le cadre d’une thèse de doctorat au laboratoire COGIT de l’IGN.

  17. Á la carte -listan uudistaminen kevät- ja kesäsesongille : case Hotelli Ravintola Ruukin Kievari

    OpenAIRE

    Räsänen, Rebekka

    2016-01-01

    Tämän toiminnallisen opinnäytetyön tavoitteena oli uudistaa Hotelli Ravintola Ruukin Kievarin á la carte -lista kevät- ja kesäsesongille 2015. Sain toimeksiannoksi suunnitella yhteistyössä henkilökunnan ja ravintoloitsijan kanssa uuden ruokalistan, joka noudattelisi aiemman ruokalistan mutkatonta ja maukasta tyyliä. Ruokalistasta haluttiin luonnollisesti myyvä sekä asiakkaiden tarpeiden ja liikeidean mukainen. Ruoka-annosten haluttiin olevan yksinkertaisen maistuvia ja hyvistä ja tuoreista ra...

  18. Disseny i construcció d’un exosquelet per la millora del cartílag del turmell

    OpenAIRE

    San Mateo Diego, Víctor

    2017-01-01

    Quan arribem a una edat avançada el cos ens comença a fallar degut al seu ús. Una de les malalties més comunes és l’artrosi. L’artrosi és una malaltia degenerativa que afecta als cartílags que, degut al seu ús, es desgasten. Aquesta malaltia pot afectar a qualsevol articulació del cos, entre elles les del turmell. Actualment per al tractament de l’artrosi al turmell es poden contemplar dos tipus de tractaments: els no quirúrgics i els quirúrgics. Els tractaments no quirúrgics estan diri...

  19. Prototipo de material polimérico compuesto a base de vasos de cartón para bebidas calientes

    OpenAIRE

    Jiménez Moreno, Luz Adriana

    2013-01-01

    La transformación de un residuo como vasos de cartón para bebidas calientes en un material compuesto polimérico requiere un análisis de las propiedades de la materia prima inicial y de los procesos que pueden llevarse a cabo de acuerdo a los recursos disponibles para la manufactura del mismo. Por medio de la selección de procedimientos experimentales, casos de estudio relevantes en el área y el uso de normas internacionales que provean un marco experimental adecuado, se realiza la caracteriza...

  20. T-cell phenotypes, apoptosis and inflammation in HIV+ patients on virologically effective cART with early atherosclerosis.

    Directory of Open Access Journals (Sweden)

    Esther Merlini

    Full Text Available OBJECTIVE: We investigated the potential relationship between T-cell phenotype, inflammation, endotoxemia, and atherosclerosis evaluated by carotid intima-media thickness (IMT in a cohort of HIV-positive patients undergoing long-term virologically suppressive combination antiretroviral therapy (cART. DESIGN: We studied 163 patients receiving virologically suppressive cART. METHODS: We measured IMT (carotid ultrasound; CD4+/CD8+ T-cell activation (CD38, CD45R0, differentiation (CD127, apoptosis (CD95, and senescence (CD28, CD57 (flow cytometry; plasma sCD14, IL-6, TNF- α, sVCAM-1, hs-CRP, anti-CMV IgG (ELISA; LPS (LAL. The results were compared by Mann-Whitney, Kruskal-Wallis or Chi-square tests, and factors associated with IMT were evaluated by multivariable logistic regression. RESULTS: Of 163 patients, 112 demonstrated normal IMT (nIMT, whereas 51 (31.3% had pathological IMT (pIMT: ≥1 mm. Of the patients with pIMT, 22 demonstrated an increased IMT (iIMT, and 29 were shown to have plaques. These patient groups had comparable nadir and current CD4+, VLs and total length of time on cART. Despite similar proportions of CD38-expressing CD8+ cells (p = .95, pIMT patients exhibited higher activated memory CD8+CD38+CD45R0+ cells (p = .038 and apoptotic CD4+CD95+ (p = .01 and CD8+CD95+ cells (p = .003. In comparison to nIMT patients, iIMT patients tended to have lower numbers of early differentiated CD28+CD57- memory CD4+ (p = .048 and CD28-CD57-CD8+ cells (p = .006, both of which are associated with a higher proliferative potential. Despite no differences in plasma LPS levels, pIMT patients showed significantly higher circulating levels of sCD14 than did nIMT patients (p = .046. No differences in anti-CMV IgG was shown. Although circulating levels of sCD14 seemed to be associated with a risk of ATS in an unadjusted analysis, this effect was lost after adjusting for classical cardiovascular predictors. CONCLUSIONS: Despite the provision of full

  1. Comparison of buffet and a la carte serving at worksite canteens on nutrient intake and fruit and vegetable consumption

    DEFF Research Database (Denmark)

    Lassen, Anne Dahl; Hansen, K.S.; Trolle, Ellen

    2007-01-01

    : Fifteen randomly chosen worksite canteens in Denmark: eight canteens serving buffet style and seven canteens with an A la carte line. Subjects: one hundred and eighty randomly chosen employees having lunch at the worksite canteens. Results: The average percentage energy from fat was 37 +/- 12 among men...... of the food for both genders. Conclusion: The results highlight the possibilities of promoting healthy food choices in the catering sector and the need to identify models of healthy catering practice. Serving buffet style appears to be a promising strategy in order to increase fruit and vegetable consumption...

  2. Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research

    Science.gov (United States)

    Inoo, Kanako; Inagaki, Ryo; Fujiwara, Kento; Sasawatari, Shigemi; Kamigaki, Takashi; Nakagawa, Shinsaku; Okada, Naoki

    2016-01-01

    We previously reported that tumor vessel-redirected T cells, which were genetically engineered with chimeric antigen receptor (CAR) specific for vascular endothelial growth factor receptor 2 (VEGFR2), demonstrated significant antitumor effects in various murine solid tumor models. In the present study, we prepared anti-VEGFR2 CAR-T cells by CAR-coding mRNA electroporation (mRNA-EP) and analyzed their immunological characteristics and functions for use in clinical research. The expression of anti-VEGFR2 CAR on murine and human T cells was detected with approximately 100% efficiency for a few days, after peaking 6–12 hours after mRNA-EP. Triple transfer of murine anti-VEGFR2 CAR-T cells into B16BL6 tumor-bearing mice demonstrated an antitumor effect comparable to that for the single transfer of CAR-T cells engineered with retroviral vector. The mRNA-EP did not cause any damage or defects to human T-cell characteristics, as determined by viability, growth, and phenotypic parameters. Additionally, two kinds of human anti-VEGFR2 CAR-T cells, which expressed different CAR construction, differentiated to effector phase with cytokine secretion and cytotoxic activity in antigen-specific manner. These results indicate that our anti-VEGFR2 CAR-T cells prepared by mRNA-EP have the potential in terms of quality and performance to offer the prospect of safety and efficacy in clinical research as cellular medicine. PMID:27909701

  3. Age, Sex & Nutritional Status Modify CD4+T-Cell Recovery Rate in HIV/Tuberculosis Co-infected Patients on cART

    Science.gov (United States)

    Ezeamama, Amara E; Mupere, Ezekiel; Oloya, James; Martinez, Leonardo; Kakaire, Robert; Yin, Xiaoping; Sekandi, Juliet N; Whalen, Christopher C

    2015-01-01

    Background We examined baseline age and combination antiretroviral therapy (cART) as determinants of CD4+T-cell recovery during six months of tuberculosis (TB) therapy with/without cART. We determined whether this association was modified by patient sex and nutritional status. Methods This longitudinal analysis included 208 immune-competent, non-pregnant, ART-naive HIV-positive patients from Uganda with a first episode of pulmonary TB. CD4+T-cell count was measured using flow cytometry. Age was defined as ≤24, 25–29, 30–34, 35–39 vs. ≥ 40 years. Nutritional status was defined as normal (>18.5kg/m2) vs. underweight (≤18.5kg/m2) using body mass index (BMI). Multivariate random-effects linear mixed models were fitted to estimate differences in CD4+T-cell recovery in relation to specified determinants. Results cART was associated with a monthly rise of 15.7 cells/μL (page was not associated with CD4+T-cell recovery during TB therapy (p=0.655). However, among patients on cART, age-associated CD4+T-cell recovery rate varied by sex and nutritional status such that age 18.5kg/m2 or female. They may benefit from increased monitoring and nutritional support during cART. PMID:25910854

  4. Design, Development, and Testing of a UAV Hardware-in-the-Loop Testbed for Aviation and Airspace Prognostics Research

    Science.gov (United States)

    Kulkarni, Chetan; Teubert, Chris; Gorospe, George; Burgett, Drew; Quach, Cuong C.; Hogge, Edward

    2016-01-01

    The airspace is becoming more and more complicated, and will continue to do so in the future with the integration of Unmanned Aerial Vehicles (UAVs), autonomy, spacecraft, other forms of aviation technology into the airspace. The new technology and complexity increases the importance and difficulty of safety assurance. Additionally, testing new technologies on complex aviation systems & systems of systems can be very difficult, expensive, and sometimes unsafe in real life scenarios. Prognostic methodology provides an estimate of the health and risks of a component, vehicle, or airspace and knowledge of how that will change over time. That measure is especially useful in safety determination, mission planning, and maintenance scheduling. The developed testbed will be used to validate prediction algorithms for the real-time safety monitoring of the National Airspace System (NAS) and the prediction of unsafe events. The framework injects flight related anomalies related to ground systems, routing, airport congestion, etc. to test and verify algorithms for NAS safety. In our research work, we develop a live, distributed, hardware-in-the-loop testbed for aviation and airspace prognostics along with exploring further research possibilities to verify and validate future algorithms for NAS safety. The testbed integrates virtual aircraft using the X-Plane simulator and X-PlaneConnect toolbox, UAVs using onboard sensors and cellular communications, and hardware in the loop components. In addition, the testbed includes an additional research framework to support and simplify future research activities. It enables safe, accurate, and inexpensive experimentation and research into airspace and vehicle prognosis that would not have been possible otherwise. This paper describes the design, development, and testing of this system. Software reliability, safety and latency are some of the critical design considerations in development of the testbed. Integration of HITL elements in

  5. MatchingLand, geospatial data testbed for the assessment of matching methods.

    Science.gov (United States)

    Xavier, Emerson M A; Ariza-López, Francisco J; Ureña-Cámara, Manuel A

    2017-12-05

    This article presents datasets prepared with the aim of helping the evaluation of geospatial matching methods for vector data. These datasets were built up from mapping data produced by official Spanish mapping agencies. The testbed supplied encompasses the three geometry types: point, line and area. Initial datasets were submitted to geometric transformations in order to generate synthetic datasets. These transformations represent factors that might influence the performance of geospatial matching methods, like the morphology of linear or areal features, systematic transformations, and random disturbance over initial data. We call our 11 GiB benchmark data 'MatchingLand' and we hope it can be useful for the geographic information science research community.

  6. Living with a Star (LWS) Space Environment Testbeds (SET), Mission Carrier Overview and Capabilities

    Science.gov (United States)

    Patschke, Robert; Barth, Janet; Label, Ken; Mariano, Carolyn; Pham, Karen; Brewer, Dana; Cuviello, Michael; Kobe, David; Wu, Carl; Jarosz, Donald

    2004-01-01

    NASA has initiated the Living With a Star (LWS) Program to develop the scientific understanding to address the aspects of the Connected Sun-Earth system that affect life and society. A goal of the program is to bridge the gap between science, engineering, and user application communities. This will enable future science, operational, and commercial objectives in space and atmospheric environments by improving engineering approaches to the accommodation and/or mitigation of the effects of solar variability on technological systems. The three program elements of the LWS Program are Science Missions; Targeted Research and Technology; and Space Environment Testbeds (SETS). SET is an ideal platform for small experiments performing research on space environment effects on technologies and on the mitigation of space weather effects. A short description of the LWS Program will be given, and the SET will be described in detail, giving the mission objectives, available carrier services, and upcoming flight opportunities.

  7. Analysis of Quantum Information Test-Bed by Parametric Down-Converted Photons Interference Measurement

    Science.gov (United States)

    To, Wing H.

    2005-01-01

    Quantum optical experiments require all the components involved to be extremely stable relative to each other. The stability can be "measured" by using an interferometric experiment. A pair of coherent photons produced by parametric down-conversion could be chosen to be orthogonally polarized initially. By rotating the polarization of one of the wave packets, they can be recombined at a beam splitter such that interference will occur. Theoretically, the interference will create four terms in the wave function. Two terms with both photons going to the same detector, and two terms will have the photons each going to different detectors. However, the latter will cancel each other out, thus no photons will arrive at the two detectors simultaneously under ideal conditions. The stability Of the test-bed can then be inferred by the dependence of coincidence count on the rotation angle.

  8. An Overview of NASA SPoRT GOES-R JPSS Proving Ground Testbed Activities

    Science.gov (United States)

    Berndt, Emily; Stano, Geoffrey; Fuell, Kevin; Leroy, Anita; Mcgrath, Kevin; Molthan, Andrew; Schultz, Lori; Smith, Matthew; White, Kris; Schultz, Christopher; hide

    2017-01-01

    The Short-term Prediction Research and Transition (SPoRT) Center is funded by NASA's Earth Science Division and NOAA's JPSS and GOES-R Proving Grounds to transition satellite products and capabilities to the NWS to improve short term (0-48 hr) forecasts on a regional and local scale. SPoRT currently collaborates with 30+ NWS WFOs (at least one in each NWS region) and 5 National Centers/Testbeds. SPoRT matches user-identified forecast challenges to specific products, providing access to these data in AWIPS through new plug-in development, and generating applications-based training to use the products for their needs (R20). Upon transition, SPoRT collaborates with the user to assess the product impact in a real-world environment for feedback to product developers (O2R) and to benefit their peers.

  9. An interactive testbed for development of expert tools for pattern recognition

    Science.gov (United States)

    Wharton, Stephen W.

    1988-01-01

    The initial implementation of an interactive testbed for development of expert system applications in image processing, i.e., a toolbox of procedures designed to facilitate the capture of expert knowledge for region grouping and analysis is described. The user can elect to interactively enter commands (via a command interpreter) for region manipulation to, in effect, simulate the actions of a hypothetical expert system. The user can then incorporate any rules and procedures as derived from interactive experimentation into customized region processing procedures using the library of utility functions. An iterative technique based on image pyramids is used to compute the initial region segmentation without the use of process parameters. These regions can then be interactively examined and manipulated using the command interpreter.

  10. Thermal and Fluid Modeling of the CRYogenic Orbital TEstbed (CRYOTE) Ground Test Article (GTA)

    Science.gov (United States)

    Piryk, David; Schallhorn, Paul; Walls, Laurie; Stopnitzky, Benny; Rhys, Noah; Wollen, Mark

    2012-01-01

    The purpose of this study was to anchor thermal and fluid system models to data acquired from a ground test article (GTA) for the CRYogenic Orbital TEstbed - CRYOTE. To accomplish this analysis, it was broken into four primary tasks. These included model development, pre-test predictions, testing support at Marshall Space Flight Center (MSFC} and post-test correlations. Information from MSFC facilitated the task of refining and correlating the initial models. The primary goal of the modeling/testing/correlating efforts was to characterize heat loads throughout the ground test article. Significant factors impacting the heat loads included radiative environments, multi-layer insulation (MLI) performance, tank fill levels, tank pressures, and even contact conductance coefficients. This paper demonstrates how analytical thermal/fluid networks were established, and it includes supporting rationale for specific thermal responses seen during testing.

  11. Low-signal, coronagraphic wavefront estimation with Kalman filtering in the high contrast imaging testbed

    Science.gov (United States)

    Riggs, A. J. Eldorado; Cady, Eric J.; Prada, Camilo M.; Kern, Brian D.; Zhou, Hanying; Kasdin, N. Jeremy; Groff, Tyler D.

    2016-07-01

    For direct imaging and spectral characterization of cold exoplanets in reflected light, the proposed Wide-Field Infrared Survey Telescope (WFIRST) Coronagraph Instrument (CGI) will carry two types of coronagraphs. The High Contrast Imaging Testbed (HCIT) at the Jet Propulsion Laboratory has been testing both coronagraph types and demonstrated their abilities to achieve high contrast. Focal plane wavefront correction is used to estimate and mitigate aberrations. As the most time-consuming part of correction during a space mission, the acquisition of probed images for electric field estimation needs to be as short as possible. We present results from the HCIT of narrowband, low-signal wavefront estimation tests using a shaped pupil Lyot coronagraph (SPLC) designed for the WFIRST CGI. In the low-flux regime, the Kalman filter and iterated extended Kalman filter provide faster correction, better achievable contrast, and more accurate estimates than batch process estimation.

  12. SAVANT analysis of the microelectronics and photonics testbed solar cell data

    Energy Technology Data Exchange (ETDEWEB)

    Walters, Robert J.; Summers, G.P. [Naval Research Lab., Code 6818, Washington, DC (United States); Messenger, S.R. [SFA, Inc., Largo, MD (United States); Morton, T.L. [Ohio Aerospace Inst., Cleveland, OH (United States)

    2005-07-01

    An analysis of solar array data from the Microelectronic and Photonic Testbed (MPTB) space experiment is presented. The data are analyzed using the displacement damage dose (D{sub d}) methodology developed by the US Naval Research Laboratory (NRL) as implemented in the Solar Array Verification and Analysis Tool (SAVANT). SAVANT is a WindowsTM-based computer code that predicts the on-orbit performance of a solar cell in a specified Earth orbit. The predicted solar cell performance produced by the SAVANT code are compared with the measured on-orbit data. In addition, the calculated data are compared with onboard dosimeter measurements. The results allow both a validation of the SAVANT code and a comparison of the space environment models with measured on-orbit data. The results show the models to match the measured data within a factor of 2. (Author)

  13. High-Resolution Adaptive Optics Test-Bed for Vision Science

    Energy Technology Data Exchange (ETDEWEB)

    Wilks, S C; Thomspon, C A; Olivier, S S; Bauman, B J; Barnes, T; Werner, J S

    2001-09-27

    We discuss the design and implementation of a low-cost, high-resolution adaptive optics test-bed for vision research. It is well known that high-order aberrations in the human eye reduce optical resolution and limit visual acuity. However, the effects of aberration-free eyesight on vision are only now beginning to be studied using adaptive optics to sense and correct the aberrations in the eye. We are developing a high-resolution adaptive optics system for this purpose using a Hamamatsu Parallel Aligned Nematic Liquid Crystal Spatial Light Modulator. Phase-wrapping is used to extend the effective stroke of the device, and the wavefront sensing and wavefront correction are done at different wavelengths. Issues associated with these techniques will be discussed.

  14. Break junction under electrochemical gating: testbed for single-molecule electronics.

    Science.gov (United States)

    Huang, Cancan; Rudnev, Alexander V; Hong, Wenjing; Wandlowski, Thomas

    2015-02-21

    Molecular electronics aims to construct functional molecular devices at the single-molecule scale. One of the major challenges is to construct a single-molecule junction and to further manipulate the charge transport through the molecular junction. Break junction techniques, including STM break junctions and mechanically controllable break junctions are considered as testbed to investigate and control the charge transport on a single-molecule scale. Moreover, additional electrochemical gating provides a unique opportunity to manipulate the energy alignment and molecular redox processes for a single-molecule junction. In this review, we start from the technical aspects of the break junction technique, then discuss the molecular structure-conductance correlation derived from break junction studies, and, finally, emphasize electrochemical gating as a promising method for the functional molecular devices.

  15. Automated tools and techniques for distributed Grid Software Development of the testbed infrastructure

    CERN Document Server

    Aguado Sanchez, C

    2007-01-01

    Grid technology is becoming more and more important as the new paradigm for sharing computational resources across different organizations in a secure way. The great powerfulness of this solution, requires the definition of a generic stack of services and protocols and this is the scope of the different Grid initiatives. As a result of international collaborations for its development, the Open Grid Forum created the Open Grid Services Architecture (OGSA) which aims to define the common set of services that will enable interoperability across the different implementations. This master thesis has been developed in this framework, as part of the two European-funded projects ETICS and OMII-Europe. The main objective is to contribute to the design and maintenance of large distributed development projects with the automated tool that enables to implement Software Engineering techniques oriented to achieve an acceptable level of quality at the release process. Specifically, this thesis develops the testbed concept a...

  16. First experiences with a parallel architecture testbed in the LHCb trigger system

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00293740; Lucchesi, Donatella; Gianelle, Alessio; Amerio, Silvia; Corvo, Marco

    2017-01-01

    In this note we will discuss the application of new technologies, such as GPU cards, in the current LHCb trigger system. During Run2, a node equipped with a GPU has been inserted in the LHCb online monitoring system. During normal data taking, real events have been sent to the node and processed by GPU-based and CPU-based tracking algorithms. This gave us the unique opportunity to test the new hardware and the new algorithms in the real-time environment of the experiment. In the following sections, we will describe the algorithm developed for parallel architectures, the setup of the testbed and the results compared to the LHCb official reconstruction.

  17. Static and dynamic optimization of CAPE problems using a Model Testbed

    DEFF Research Database (Denmark)

    This paper presents a new computer aided tool for setting up and solving CAPE related static and dynamic optimisation problems. The Model Testbed (MOT) offers an integrated environment for setting up and solving a very large range of CAPE problems, including complex optimisation problems...... in the different stages of the process lifecycle. The usefulness of MoT is illustrated through a case study, which highlights the design and optimisation of a continuous stirred tank reactor as steps in the process model lifecycle. It is demonstrated how this integrated environment is used for both static...... and dynamic optimisation, and how interfacing of solvers and seamless information flow can lead to more efficient solution of process design problems....

  18. Analysis of 100Mb/s Ethernet for the Whitney Commodity Computing Testbed

    Science.gov (United States)

    Fineberg, Samuel A.; Pedretti, Kevin T.; Kutler, Paul (Technical Monitor)

    1997-01-01

    We evaluate the performance of a Fast Ethernet network configured with a single large switch, a single hub, and a 4x4 2D torus topology in a testbed cluster of "commodity" Pentium Pro PCs. We also evaluated a mixed network composed of ethernet hubs and switches. An MPI collective communication benchmark, and the NAS Parallel Benchmarks version 2.2 (NPB2) show that the torus network performs best for all sizes that we were able to test (up to 16 nodes). For larger networks the ethernet switch outperforms the hub, though its performance is far less than peak. The hub/switch combination tests indicate that the NAS parallel benchmarks are relatively insensitive to hub densities of less than 7 nodes per hub.

  19. Observed and simulated temperature dependence of the liquid water path of low clouds

    Energy Technology Data Exchange (ETDEWEB)

    Del Genio, A.D.; Wolf, A.B. [NASA Goddard Institute for Space Studies, New York, NY (United States)

    1996-04-01

    Data being acquired at the Atmospheric Radiation Measurement (ARM) Southern great Plains (SGP) Cloud and Radiation Testbed (CART) site can be used to examine the factors determining the temperature dependence of cloud optical thickness. We focus on cloud liquid water and physical thickness variations which can be derived from existing ARM measurements.

  20. Observations of a cold front with strong vertical undulations during the ARM RCS-IOP

    Energy Technology Data Exchange (ETDEWEB)

    Starr, D.O`C.; Whiteman, D.N. [Goddard Space Flight Center, Greenbelt, MD (United States); Melfi, S.H. [Univ. of Maryland, Baltimore, MD (United States)] [and others

    1996-04-01

    Passage of a cold front was observed on the night of April 14-15, 1994, during the Atmospheric Radiation Measurement (ARM) Remote Cloud Sensing (RCS) Intensive Observatios Period (IOP) at the Southern Great Plains Cloud and Radiation Testbed (CART) site near Lamont, Oklahoma. The observations are described.

  1. Causas e consequências da dívida no cartão de crédito: uma análise multifatores

    OpenAIRE

    Kunkel, Franciele Inês Reis; Vieira, Kelmara Mendes; Potrich, Ani Caroline Grigion

    2015-01-01

    RESUMONeste estudo, o objetivo é avaliar as causas e as consequências da dívida no cartão de crédito a partir de fatores comportamentais. Realizou-se uma pesquisa com 1.831 usuários de cartão de crédito dos estados de Rio Grande do Sul, Minas Gerais e Maranhão por meio da aplicação de questionários. Inicialmente, observou-se que os respondentes mantêm baixos índices de endividamento no cartão de crédito. Nos resultados obtidos com a modelagem de equações estruturais, apontam-se como determina...

  2. CART peptide in the nucleus accumbens shell inhibits cocaine-induced locomotor sensitization to transient overexpression of α-Ca2+/Calmodulin-dependent Protein Kinase II.

    Science.gov (United States)

    Xiong, Lixia; Meng, Qing; Sun, Xi; Lu, Xiangtong; Fu, Qiang; Peng, Qinghua; Yang, Jianhua; Oh, Ki-Wan; Hu, Zhen Zhen

    2018-01-04

    Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter that attenuates cocaine-induced locomotor activity when injected into the nucleus accumbens (NAc). Our previous work first confirmed that the inhibitory mechanism of the CART peptide on cocaine-induced locomotor activity is related to a reduction in cocaine-enhanced phosphorylated Ca2+ /calmodulin-dependent protein kinaseIIα (pCaMKIIα) and the enhancement of cocaine-induced D3R function. The present study investigated whether CART peptide inhibited cocaine-induced locomotor activity via inhibition of interactions between pCaMKIIα and the D3 dopamine receptor (D3R). We demonstrated that lentivirus-mediated gene transfer transiently increased pCaMKIIα expression, which peaked at 10 days after microinjection into the rat NAc shell, and induced a significant increase in Ca2+ influx along with greater behavioral sensitivity in the open field test after intraperitoneal injections of cocaine (15 mg/kg). However, western blot analysis and coimmunoprecipitation demonstrated that CART peptide treatment in lentivirus-transfected CaMKIIα-overexpressing NAc rat tissues or cells prior to cocaine administration inhibited the cocaine-induced Ca2+ influx and attenuated the cocaine-increased pCaMKIIα expression in lentivirus-transfected CaMKIIα-overexpressing cells. CART peptide decreased the cocaine-enhanced phosphorylated cAMP response element binding protein (pCREB) expression via inhibition of the pCaMKIIα-D3R interaction, which may account for the prolonged locomotor sensitization induced by repeated cocaine treatment in lentivirus-transfected CaMKIIα-overexpressing cells. These results provide strong evidence for the inhibitory modulation of CART peptide in cocaine-induced locomotor sensitization. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  3. Distribution of cocaine- and amphetamine-regulated transcript (CART), neuropeptide Y (NPY) and galanin (GAL) in the pterygopalatine ganglion of the domestic duck (Anas platyrhynchos f. domestica).

    Science.gov (United States)

    Radzimirska, Malgorzata; Bogus-Nowakowska, Krystyna; Kuder, Tadeusz; Robak, Anna

    2016-01-01

    Cocaine- and amphetamine-regulated transcript (CART), neuropeptide Y (NPY) and galanin (GAL) act as neurotransmitters and neuromodulators in both the central and peripheral nervous systems. Their presence has been found in different taxonomic groups, in particular in mammals. However, only few investigators have studied these neuropeptides in the class Aves (birds). The aim of the present study was to describe the distribution of CART, NPY and GAL in the pterygopalatine ganglion (PPG) of the domestic duck (Anas platyrhynchos f. domestica). The experiment was conducted on 16 one-year-old domestic ducks of the Pekin breed of both sexes (8 males and 8 females). Frozen sections of the PPG were subjected to immunofluorescence staining using primary mouse monoclonal antibodies directed against CART and GAL and rabbit polyclonal antibody directed against NPY. Secondary antibodies were conjugated with Cy3 and FITC fluorochromes. CART, NPY, and GAL were present in the PPG of the domestic duck. The highest immunoreactivity (IR) in the ganglionic cells was found for CART in the majority (83-85%) of neurons of both superior (SPPG) and inferior (IPPG) PPG. CART-IR was also found in small aggregations of neurons on the medial surface of the Harderian gland, and on the course of the palatine branch of the facial nerve. CART-IR was also observed in the nerve fibers of these neurons' aggregations; however, it was low in comparison to the immunoreactivity of the perikarya. Immunoreactivity of NPY was found in ganglionic neurons, but above all in numerous fibers of the SPPG and IPPG and within aggregations on the surface of the Harderian gland. NPY-IR cells were distributed irregularly over the cross-sections of the tested aggregations, and constituted from 36% to 43% of the SPPG and from 37% to 40% of the IPPG of all cross-sectioned neurons. GAL-immunoreactive perikarya, distributed irregularly across the sections, were observed in the SPPG, where they constituted 61-65%, and in the

  4. Analysis, modeling, and simulation (AMS) testbed development and evaluation to support dynamic mobility applications (DMA) and active transportation and demand management (ATDM) programs - Pasadena calibration report : draft report.

    Science.gov (United States)

    2017-03-01

    The primary objective of this project is to develop multiple simulation testbeds/transportation models to : evaluate the impacts of DMA connected vehicle applications and the active transportation and demand : management (ATDM) strategies. The primar...

  5. The Soil Moisture Active Passive Mission (SMAP) Science Data Products: Results of Testing with Field Experiment and Algorithm Testbed Simulation Environment Data

    Science.gov (United States)

    Entekhabi, Dara; Njoku, Eni E.; O'Neill, Peggy E.; Kellogg, Kent H.; Entin, Jared K.

    2010-01-01

    Talk outline 1. Derivation of SMAP basic and applied science requirements from the NRC Earth Science Decadal Survey applications 2. Data products and latencies 3. Algorithm highlights 4. SMAP Algorithm Testbed 5. SMAP Working Groups and community engagement

  6. Design and Test of an Attitude Determination and Control System for a 6U CubeSat using AFIT’s CubeSat Testbed

    Science.gov (United States)

    2015-03-01

    Including Sensor Bias in Shape from Motion Calibration and Sensor Fusion ”. Multisensor Fusion and Integration for Intelligent Systems, 1996. IEEE/SICE...for attitude determination. Along with the ADCS hardware, the ADCS testbed also includes an Electrical Power System (EPS) and Command and Data ...eter sensor data to estimate a current quaternion. A Proportional-Integral-Derivative (PID) controller is used for control of the ADCS testbed while

  7. Implementation of Motion Simulation Software and Visual-Auditory Electronics for Use in a Low Gravity Robotic Testbed

    Science.gov (United States)

    Martin, William Campbell

    2011-01-01

    The Jet Propulsion Laboratory (JPL) is developing the All-Terrain Hex-Limbed Extra-Terrestrial Explorer (ATHLETE) to assist in manned space missions. One of the proposed targets for this robotic vehicle is a near-Earth asteroid (NEA), which typically exhibit a surface gravity of only a few micro-g. In order to properly test ATHLETE in such an environment, the development team has constructed an inverted Stewart platform testbed that acts as a robotic motion simulator. This project focused on creating physical simulation software that is able to predict how ATHLETE will function on and around a NEA. The corresponding platform configurations are calculated and then passed to the testbed to control ATHLETE's motion. In addition, imitation attitude, imitation attitude control thrusters were designed and fabricated for use on ATHLETE. These utilize a combination of high power LEDs and audio amplifiers to provide visual and auditory cues that correspond to the physics simulation.

  8. Evaluasi Kinerja Layanan IPTV pada Jaringan Testbed WiMAX Berbasis Standar IEEE 802.16-2004

    Directory of Open Access Journals (Sweden)

    Prasetiyono Hari Mukti

    2015-09-01

    Full Text Available In this paper, a performance evaluation for IPTV Services over WiMAX testbed based on IEEE Standard 802.16-2004 will be described. The performance of the proposed system is evaluated in terms of delay, jitter, throughput and packet loss. Service performance evaluations are conducted on network topology of point-to-point in the variation of background traffic with different scheduling types. Background traffic is injected into the system to give the sense that the proposed system has variation traffic load. Scheduling type which are used in this paper are Best Effort (BE, Non-Real-Time Polling Service (nrtPS, Real-Time Polling Service (rtPS and Unsolicited Grant Service (UGS. The expemerintal results of IPTV service performance over the testbed network show that the maximum average of delay, jitter, packet loss and jitter are 16.581 ms, 58.515 ms, 0.67 Mbps dan 10.96%, respectively.

  9. Oceanic Platform of the Canary Islands: an ocean testbed for ocean energy converters

    Science.gov (United States)

    González, Javier; Hernández-Brito, Joaquín.; Llinás, Octavio

    2010-05-01

    The Oceanic Platform of the Canary Islands (PLOCAN) is a Governmental Consortium aimed to build and operate an off-shore infrastructure to facilitate the deep sea research and speed up the technology associated. This Consortium is overseen by the Spanish Ministry of Science and Innovation and the Canarian Agency for Research and Innovation. The infrastructure consists of an oceanic platform located in an area with depths between 50-100 meters, close to the continental slope and four kilometers off the coast of Gran Canaria, in the archipelago of the Canary Islands. The process of construction will start during the first months of 2010 and is expected to be finished in mid-year 2011. PLOCAN serves five strategic lines: an integral observatory able to explore from the deep ocean to the atmosphere, an ocean technology testbed, a base for underwater vehicles, an innovation platform and a highly specialized training centre. Ocean energy is a suitable source to contribute the limited mix-energy conformed in the archipelago of the Canary Islands with a total population around 2 million people unequally distributed in seven islands. Islands of Gran Canaria and Tenerife support the 80% of the total population with 800.000 people each. PLOCAN will contribute to develop the ocean energy sector establishing a marine testbed allowing prototypes testing at sea under a meticulous monitoring network provided by the integral observatory, generating valuable information to developers. Reducing costs throughout an integral project management is an essential objective to be reach, providing services such as transportation, customs and administrative permits. Ocean surface for testing activities is around 8 km2 with a depth going from 50 to 100 meters, 4km off the coast. Selected areas for testing have off-shore wind power conditions around 500-600 W/m2 and wave power conditions around 6 kW/m in the East coast and 10 kW/m in the North coast. Marine currents in the Canary Islands are

  10. Use of Cultivation Data from the Algae Testbed Public Private Partnership as Utilized in NREL's Algae State of Technology Assessments

    Energy Technology Data Exchange (ETDEWEB)

    Knoshaug, Eric [National Renewable Energy Lab. (NREL), Golden, CO (United States); Laurens, Lieve [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kinchin, Christopher [National Renewable Energy Lab. (NREL), Golden, CO (United States); Davis, Ryan [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-10-01

    The Algae Testbed Public Private Partnership (ATP3) conducted algal growth experiments over the course of 16 months termed the Unified Field Studies (UFS). These experiments were conducted at 5 different geographic locations in Arizona (ASU), California (CP), Florida (FA), Georgia (GT), and Hawaii (CELL). The UFS sought to evaluate different algal biomass harvesting strategies using identical ponds, media, and operational conditions through all four seasons across different geographic regions to isolate the effects on productivity attributed to locational climate and seasonal variability, overlaid by the differing harvest strategies. Set up as the baseline against which other experiments would build upon, it must be emphasized that as per the stated, approved experimental goals of the ATP3 UFS, no attempts at growth or lipid accumulation optimization were made; rather, the primary focus of the UFS work was to cultivate algal biomass under deliberate, consistent conditions, time periods, and harvesting protocols, to provide public data on year-round outdoor biomass production that could be directly compared between one site and another (with accompanying climate data for each site). Thus the resulting productivity numbers in effect represent a conservative baseline of non-optimized algal growth one may expect at these sites. Also clearly weather can vary dramatically from season to season and from year to year, and even within a given 'season' where an individual season's data was typically based on 4-6 week operating windows. Thus these numbers also only reflect a short snapshot in time, and must be interpreted carefully in projecting what may be expected over many years or decades (for example, a 30-year facility lifetime as evaluated in techno-economic models).

  11. Aumento de dorso nasal con implante blando de tejido conectivo laxo y cartílago troce

    Directory of Open Access Journals (Sweden)

    Mariana Vásquez-García

    Full Text Available Introducción y Objetivo: Están descritas innumerables técnicas para el aumento del dorso nasal. Los injertos autólogos son el material preferido en la reconstrucción nasal debido a su biocompatibilidad y a su menor riesgo de infección y exposición. La técnica de cartílago troceado envuelto en fascia temporal se ha popularizado porque evita la visualización de los injertos a través de la piel del dorso nasal. Nuestro estudio tiene como objetivo demostrar que también el tejido conectivo laxo retroauricular es una envoltura útil para conformar con el cartílago troceado un implante blando que aumente el dorso nasal, proporcionando un resultado estético natural. Material y Método: Realizamos un estudio retrospectivo, entre diciembre de 2012 a diciembre de 2015 con 15 pacientes sometidos a aumento de dorso nasal con cartílago troceado de septum y concha auricular envuelto en tejido conectivo laxo retroauricular, utilizando la vía de rinoplastia externa. Evaluamos los resultados de forma subjetiva con un cuestionario entregado a los pacientes y observando las fotos pre y postoperatorias a corto, medio y largo plazo. Objetivamente medimos las alturas del dorso nasal pre y postoperatoriamente. Resultados: Todos los pacientes presentaron resultados muy satisfactorios. El valor promedio de aumento del dorso nasal a los 3 meses de postoperatorio en nasion fue de 0.38 cm, en rinion de 0.39 cm y en suprapunta de 0.41 cm, manteniéndose iguales valores a los 6, 12 y 18 meses. Conclusiones: Destacamos los beneficios de la envoltura con tejido conectivo laxo retroauricular para cubrir de forma natural las irregularidades del dorso nasal, eliminando el estigma de nariz operada (fibrosis y cicatrización anómala. Su viabilidad en la zona receptora (dorso nasal lo hace muy recomendable para la corrección de deformidades de esta zona. Es por ello que recomendamos su uso como alternativa para corregir hundimientos de dorso nasal de origen

  12. PNNL Strategic Goods Testbed: A Data Library for Illicit Nuclear Trafficking

    Energy Technology Data Exchange (ETDEWEB)

    Webster, Jennifer B.; Erikson, Luke E.; Toomey, Christopher M.; Lewis, Valerie A.

    2014-05-12

    Pacific Northwest National Laboratory (PNNL) has put significant effort into nonproliferation activities as an institution, both in terms of the classical nuclear material focused approach and in the examination of other strategic goods necessary to implement a nuclear program. To assist in these efforts, several projects in the Analysis in Motion (AIM) and Signature Discovery (SDI) Initiatives at PNNL are developing machine learning methodology for human-computer interaction in real time environments to assist analysts in this domain. All of these technical projects require access to data – whether it is in terms of detector data, shipping records, financial information, company relations, or other communications. The first question that mathematical and computational researchers come up with when asked to build analyst assist or automated tools is “What does the data look like? ” They become frustrated when basic questions like this can not be easily answered and this can have the effect of pushing researchers away from the nuclear trafficking domain, especially in strategic commodity and export control areas where data sets can not easily be generated through standard experimental techniques. For small projects that are building a proof of concept for their methodology, obtaining this data can be arduous and expensive. To relieve the burden of data collection from these projects and grow a lab-wide capability, the Strategic Goods Testbed Team has taken over data collection and placed subscriptions and access to flat data files in a centralized location so that all projects can benefit from these items. We have collected shipping data in the form of PIERS records, judicial information about export control cases, NAC data on the nuclear fuel industry, and financial data from Dun and Bradstreet and our data sets are continuing to expand. With a single access agreement, researchers in data-mining and other fields can utilize all of the records that have been

  13. Dynamic Testing of the NASA Hypersonic Project Combined Cycle Engine Testbed for Mode Transition Experiments

    Science.gov (United States)

    2011-01-01

    NASA is interested in developing technology that leads to more routine, safe, and affordable access to space. Access to space using airbreathing propulsion systems has potential to meet these objectives based on Airbreathing Access to Space (AAS) system studies. To this end, the NASA Fundamental Aeronautics Program (FAP) Hypersonic Project is conducting fundamental research on a Turbine Based Combined Cycle (TBCC) propulsion system. The TBCC being studied considers a dual flow-path inlet system. One flow-path includes variable geometry to regulate airflow to a turbine engine cycle. The turbine cycle provides propulsion from take-off to supersonic flight. The second flow-path supports a dual-mode scramjet (DMSJ) cycle which would be initiated at supersonic speed to further accelerate the vehicle to hypersonic speed. For a TBCC propulsion system to accelerate a vehicle from supersonic to hypersonic speed, a critical enabling technology is the ability to safely and effectively transition from the turbine to the DMSJ-referred to as mode transition. To experimentally test methods of mode transition, a Combined Cycle Engine (CCE) Large-scale Inlet testbed was designed with two flow paths-a low speed flow-path sized for a turbine cycle and a high speed flow-path designed for a DMSJ. This testbed system is identified as the CCE Large-Scale Inlet for Mode Transition studies (CCE-LIMX). The test plan for the CCE-LIMX in the NASA Glenn Research Center (GRC) 10- by 10-ft Supersonic Wind Tunnel (10x10 SWT) is segmented into multiple phases. The first phase is a matrix of inlet characterization (IC) tests to evaluate the inlet performance and establish the mode transition schedule. The second phase is a matrix of dynamic system identification (SysID) experiments designed to support closed-loop control development at mode transition schedule operating points for the CCE-LIMX. The third phase includes a direct demonstration of controlled mode transition using a closed loop control

  14. Developing the science product algorithm testbed for Chinese next-generation geostationary meteorological satellites: Fengyun-4 series

    Science.gov (United States)

    Min, Min; Wu, Chunqiang; Li, Chuan; Liu, Hui; Xu, Na; Wu, Xiao; Chen, Lin; Wang, Fu; Sun, Fenglin; Qin, Danyu; Wang, Xi; Li, Bo; Zheng, Zhaojun; Cao, Guangzhen; Dong, Lixin

    2017-08-01

    Fengyun-4A (FY-4A), the first of the Chinese next-generation geostationary meteorological satellites, launched in 2016, offers several advances over the FY-2: more spectral bands, faster imaging, and infrared hyperspectral measurements. To support the major objective of developing the prototypes of FY-4 science algorithms, two science product algorithm testbeds for imagers and sounders have been developed by the scientists in the FY-4 Algorithm Working Group (AWG). Both testbeds, written in FORTRAN and C programming languages for Linux or UNIX systems, have been tested successfully by using Intel/g compilers. Some important FY-4 science products, including cloud mask, cloud properties, and temperature profiles, have been retrieved successfully through using a proxy imager, Himawari-8/Advanced Himawari Imager (AHI), and sounder data, obtained from the Atmospheric InfraRed Sounder, thus demonstrating their robustness. In addition, in early 2016, the FY-4 AWG was developed based on the imager testbed—a near real-time processing system for Himawari-8/AHI data for use by Chinese weather forecasters. Consequently, robust and flexible science product algorithm testbeds have provided essential and productive tools for popularizing FY-4 data and developing substantial improvements in FY-4 products.

  15. Real-Time Emulation of Heterogeneous Wireless Networks with End-to-Edge Quality of Service Guarantees: The AROMA Testbed

    Directory of Open Access Journals (Sweden)

    Anna Umbert

    2010-01-01

    Full Text Available This work presents and describes the real-time testbed for all-IP Beyond 3G (B3G heterogeneous wireless networks that has been developed in the framework of the European IST AROMA project. The main objective of the AROMA testbed is to provide a highly accurate and realistic framework where the performance of algorithms, policies, protocols, services, and applications for a complete heterogeneous wireless network can be fully assessed and evaluated before bringing them to a real system. The complexity of the interaction between all-IP B3G systems and user applications, while dealing with the Quality of Service (QoS concept, motivates the development of this kind of emulation platform where different solutions can be tested in realistic conditions that could not be achieved by means of simple offline simulations. This work provides an in-depth description of the AROMA testbed, emphasizing many interesting implementation details and lessons learned during the development of the tool that may result helpful to other researchers and system engineers in the development of similar emulation platforms. Several case studies are also presented in order to illustrate the full potential and capabilities of the presented emulation platform.

  16. A testbed to explore the optimal electrical stimulation parameters for suppressing inter-ictal spikes in human hippocampal slices.

    Science.gov (United States)

    Min-Chi Hsiao; Pen-Ning Yu; Dong Song; Liu, Charles Y; Heck, Christi N; Millett, David; Berger, Theodore W

    2014-01-01

    New interventions using neuromodulatory devices such as vagus nerve stimulation, deep brain stimulation and responsive neurostimulation are available or under study for the treatment of refractory epilepsy. Since the actual mechanisms of the onset and termination of the seizure are still unclear, most researchers or clinicians determine the optimal stimulation parameters through trial-and-error procedures. It is necessary to further explore what types of electrical stimulation parameters (these may include stimulation frequency, amplitude, duration, interval pattern, and location) constitute a set of optimal stimulation paradigms to suppress seizures. In a previous study, we developed an in vitro epilepsy model using hippocampal slices from patients suffering from mesial temporal lobe epilepsy. Using a planar multi-electrode array system, inter-ictal activity from human hippocampal slices was consistently recorded. In this study, we have further transferred this in vitro seizure model to a testbed for exploring the possible neurostimulation paradigms to inhibit inter-ictal spikes. The methodology used to collect the electrophysiological data, the approach to apply different electrical stimulation parameters to the slices are provided in this paper. The results show that this experimental testbed will provide a platform for testing the optimal stimulation parameters of seizure cessation. We expect this testbed will expedite the process for identifying the most effective parameters, and may ultimately be used to guide programming of new stimulating paradigms for neuromodulatory devices.

  17. A Testbed to Evaluate the FIWARE-Based IoT Platform in the Domain of Precision Agriculture.

    Science.gov (United States)

    Martínez, Ramón; Pastor, Juan Ángel; Álvarez, Bárbara; Iborra, Andrés

    2016-11-23

    Wireless sensor networks (WSNs) represent one of the most promising technologies for precision farming. Over the next few years, a significant increase in the use of such systems on commercial farms is expected. WSNs present a number of problems, regarding scalability, interoperability, communications, connectivity with databases and data processing. Different Internet of Things middleware is appearing to overcome these challenges. This paper checks whether one of these middleware, FIWARE, is suitable for the development of agricultural applications. To the authors' knowledge, there are no works that show how to use FIWARE in precision agriculture and study its appropriateness, its scalability and its efficiency for this kind of applications. To do this, a testbed has been designed and implemented to simulate different deployments and load conditions. The testbed is a typical FIWARE application, complete, yet simple and comprehensible enough to show the main features and components of FIWARE, as well as the complexity of using this technology. Although the testbed has been deployed in a laboratory environment, its design is based on the analysis of an Internet of Things use case scenario in the domain of precision agriculture.

  18. A Testbed to Evaluate the FIWARE-Based IoT Platform in the Domain of Precision Agriculture

    Science.gov (United States)

    Martínez, Ramón; Pastor, Juan Ángel; Álvarez, Bárbara; Iborra, Andrés

    2016-01-01

    Wireless sensor networks (WSNs) represent one of the most promising technologies for precision farming. Over the next few years, a significant increase in the use of such systems on commercial farms is expected. WSNs present a number of problems, regarding scalability, interoperability, communications, connectivity with databases and data processing. Different Internet of Things middleware is appearing to overcome these challenges. This paper checks whether one of these middleware, FIWARE, is suitable for the development of agricultural applications. To the authors’ knowledge, there are no works that show how to use FIWARE in precision agriculture and study its appropriateness, its scalability and its efficiency for this kind of applications. To do this, a testbed has been designed and implemented to simulate different deployments and load conditions. The testbed is a typical FIWARE application, complete, yet simple and comprehensible enough to show the main features and components of FIWARE, as well as the complexity of using this technology. Although the testbed has been deployed in a laboratory environment, its design is based on the analysis of an Internet of Things use case scenario in the domain of precision agriculture. PMID:27886091

  19. Causas e consequências da dívida no cartão de crédito: uma análise multifatores

    Directory of Open Access Journals (Sweden)

    Franciele Inês Reis Kunkel

    2015-06-01

    Full Text Available RESUMO Neste estudo, o objetivo é avaliar as causas e as consequências da dívida no cartão de crédito a partir de fatores comportamentais. Realizou-se uma pesquisa com 1.831 usuários de cartão de crédito dos estados de Rio Grande do Sul, Minas Gerais e Maranhão por meio da aplicação de questionários. Inicialmente, observou-se que os respondentes mantêm baixos índices de endividamento no cartão de crédito. Nos resultados obtidos com a modelagem de equações estruturais, apontam-se como determinantes da dívida os construtos materialismo, compras compulsivas, comportamento de uso no cartão de crédito e alfabetização financeira; e como consequências, o baixo nível de bem-estar financeiro e as emoções negativas.

  20. Risk Factors for Non-Adherence to cART in Immigrants with HIV Living in the Netherlands: Results from the ROtterdam ADherence (ROAD) Project

    NARCIS (Netherlands)

    Been, Sabrina K.; van de Vijver, David A. M. C.; Nieuwkerk, Pythia T.; Brito, Inês; Stutterheim, Sarah E.; Bos, Arjan E. R.; Wolfers, Mireille E. G.; Pogány, Katalin; Verbon, Annelies

    2016-01-01

    In the Netherlands, immigrant people living with HIV (PLWH) have poorer psychological and treatment outcomes than Dutch PLWH. This cross-sectional field study examined risk factors for non-adherence to combination Antiretroviral Therapy (cART) among immigrant PLWH. First and second generation

  1. Risk factors for non-adherence to cART in immigrants with HIV living in the Netherlands: Results from the Rotterdam ADherence (ROAD) project

    NARCIS (Netherlands)

    S.K. Been; D.A.M.C. van de Vijver (David); P.T. Nieuwkerk (Pythia); Brito, I. (Inês); J. Stutterheim (Janine); A.E.R. Bos (Arjan); M.E.G. Wolfers (Mireille); K. Pogány (Katalin); A. Verbon (Annelies)

    2016-01-01

    textabstractIn the Netherlands, immigrant people living with HIV (PLWH) have poorer psychological and treatment outcomes than Dutch PLWH. This cross-sectional field study examined risk factors for non-adherence to combination Antiretroviral Therapy (cART) among immigrant PLWH. First and second

  2. Brief Report: High Need to Switch cART or Comedication With the Initiation of DAAs in Elderly HIV/HCV-Coinfected Patients

    NARCIS (Netherlands)

    Smolders, E.J.; Smit, C.; Kanter, C.T.M.M. de; Dofferiiof, A.S.M.; Arends, J.E.; Brinkman, K.; Rijnders, B.; Valk, M. van der; Reiss, P.; Burger, D.M.

    2017-01-01

    BACKGROUND: To describe the use of nonantiretroviral comedication and combination antiretroviral therapy (cART) in patients coinfected with HIV/hepatitis C virus (HCV) and to predict the potential for drug-drug interactions (DDIs) with direct-acting antivirals (DAAs) against HCV. METHODS: This is a

  3. L4-L5 compression and anterior/posterior joint shear forces in cabin attendants during the initial push/pull actions of airplane meal carts

    DEFF Research Database (Denmark)

    Sandfeld, Jesper; Rosgaard, Christian; Jensen, Bente Rona

    2014-01-01

    The aim of the present study was to assess the acute low back load of cabin attendants during cart handling and to identify working situations which present the highest strain on the worker. In a setup, 17 cabin attendants (ten females and seven males) pushed, pulled and turned a 20kg standard me...

  4. L4-L5 compression and anterior/posterior joint shear forces in cabin attendants during the initial push/pull actions of airplane meal carts.

    Science.gov (United States)

    Sandfeld, Jesper; Rosgaard, Christian; Jensen, Bente Rona

    2014-07-01

    The aim of the present study was to assess the acute low back load of cabin attendants during cart handling and to identify working situations which present the highest strain on the worker. In a setup, 17 cabin attendants (ten females and seven males) pushed, pulled and turned a 20 kg standard meal cart (L: 0.5m × W: 0.3 m × H: 0.92 m) loaded with extra 20 kg and 40 kg, respectively on two different surfaces (carpet and linoleum) and at three floor inclinations (-2°, 0° and +2°). Two force transducers were mounted as handles. Two-dimensional movement analysis was performed and a 4D WATBAK modelling tool was used to calculate the acute L4-L5 load. No working situations created loads greater than the accepted values for single exertions, however compression and anterior/posterior shear forces during pulling and turning were much higher when compared with pushing. There were significant effects of handling the cart on different floor types, at the varying inclinations and with different cart weights. Additionally, when external forces were reduced, the cabin attendants did not decrease push/pull force proportionally and thus the L4-L5 load did not decrease as much as expected. Copyright © 2014 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  5. A Study to Assess the Effectiveness of An A-La-Carte Feeding System at Naval Regional Medical Center, Orlando, Florida.

    Science.gov (United States)

    1982-08-01

    patrons subsisted in kind. When calculating the ration rate, the food service manager does not segregate and accumulate related labor, supply, utility...la-carte food serving system at the Naval Regional Medical Center, Orlando. The goal of the food service manager , to provide the highest quality meal

  6. Does less frequent routine monitoring of patients on a stable, fully suppressed cART regimen lead to an increased risk of treatment failure?

    DEFF Research Database (Denmark)

    Reekie, Joanne; Mocroft, Amanda; Sambatakou, Helen

    2008-01-01

    OBJECTIVE: To investigate whether HIV-infected patients on a stable and fully suppressive combination antiretroviral therapy (cART) regimen could safely be monitored less often than the current recommendations of every 3 months. DESIGN: Two thousand two hundred and forty patients from the Euro...

  7. Changes in first-line cART regimens and short-term clinical outcome between 1996 and 2010 in The Netherlands

    NARCIS (Netherlands)

    Smit, Mikaela; Smit, Colette; Geerlings, Suzanne; Gras, Luuk; Brinkman, Kees; Hallett, Timothy B.; de Wolf, Frank; Prins, J. M.; Kuijpers, T. W.; Scherpbier, H. J.; van der Meer, J. T. M.; Wit, F. W. M. N.; Godfried, M. H.; Reiss, P.; van der Poll, T.; Nellen, F. J. B.; Lange, J. M. A.; van Vugt, M.; Pajkrt, D.; Bos, J. C.; van der Valk, M.; Grijsen, M. L.; Wiersinga, W. J.; Lowe, S.; Schreij, G.; Oude Lashof, A.; Posthouwer, D.; Pronk, M. J. H.; Bravenboer, B.; van der Ende, M. E.; de Vries-Sluijs, T. E. M. S.; Schurink, C. A. M.; Nouwen, J. L.; tot Pannerden, M. H. Nispen; Verbon, A.; Rijnders, B. J. A.; van Gorp, E. C. M.; Hassing, R. J.; Smeulders, A. W. M.; Hartwig, N. G.; Driessen, G. J. A.; Branger, J.; Schippers, E. F.; van Nieuwkoop, C.; van Elzakker, E. P.; Groeneveld, P. H. P.; Alleman, M. A.; Bouwhuis, J. W.; Soetekouw, R.; ten Kate, R. W.; Kroon, F. P.; van Dissel, J. T.; Arend, S. M.; de Boer, M. G. J.; Jolink, H.; ter Vollaard, H. J. M.; Bauer, M. P.; den Hollander, J. G.; Pogany, K.; van Twillert, G.; Kortmann, W.; Leyten, E. M. S.; Gelinck, L. B. S.; Kootstra, G. J.; Delsing, C. E.; Brinkman, K.; Blok, W. L.; Frissen, P. H. J.; Schouten, W. E. M.; van den Berk, G. E. L.; van Kasteren, M. E. E.; Veenstra, J.; Lettinga, K. D.; Mulder, J. W.; Vrouenraets, S. M. E.; Lauw, F. N.; van Eeden, A.; Verhagen, D. W. M.; Sprenger, H. G.; Doedens, R.; Scholvinck, E. H.; van Assen, S.; Bierman, W. F. W.; Koopmans, P. P.; Keuter, M.; van der Ven, A. J. A. M.; ter Hofstede, H. J. M.; Dofferhoff, A. S. M.; Warris, A.; van Crevel, R.; Hoepelman, A. I. M.; Mudrikova, T.; Schneider, M. M. E.; Ellerbroek, P. M.; Oosterheert, J. J.; Arends, J. E.; Wassenberg, M. W. M.; Barth, R. E.; van Agtmael, M. A.; Perenboom, R. M.; Claessen, F. A. P.; Bomers, M.; Peters, E. J. G.; Geelen, S. P. M.; Wolfs, T. F. W.; Bont, L. J.; Richter, C.; van der Berg, J. P.; Gisolf, E. H.; van den Berge, M.; Stegeman, A.; van Vonderen, M. G. A.; van Houte, D. P. F.; Weijer, S.; el Moussaoui, R.; Winkel, C.; Muskiet, F.; Durand, N. N.; Voigt, R.

    2013-01-01

    Document progress in HIV-treatment in The Netherlands since 1996 by reviewing changing patterns of cART use and relating those to trends in patients' short-term clinical outcomes between 1996 and 2010. 1996-2010 data from 10,278 patients in the Dutch ATHENA national observational cohort were

  8. La Carte du Ciel et l'ajustement des pratiques (fin XIXe et début XXe siècle)

    Science.gov (United States)

    Lamy, J.

    2008-06-01

    Ce chapitre s'intéresse aux modes d'organisation et de coordination qui caractérisent la Carte du Ciel. La standardisation des instruments et la normalisation des pratiques s'opèrent sur un mode directif. Les instances dirigeantes de la Carte du Ciel élaborent des règles très contraignantes pour uniformiser les opérations. Les astronomes doivent donc ajuster les normes édictées à leur expérience d'observateurs. Les débats qui agitent les conférences internationales de la Carte du Ciel réunies à Paris en 1887, 1889 et 1891, permettent d'apaiser les tensions entre prescriptions et pratiques individuelles. De plus, le Bulletin du Comité international permanent pour l'exécution de la Carte du Ciel, véritable forum informel, offre un espace inédit de discussion sur les aménagements à envisager.

  9. The impact of type of manual medication cart filling method on the frequency of medication administration errors : A prospective before and after study

    NARCIS (Netherlands)

    Schimmel, Anneliene M.; Becker, Matthijs L.; van den Bout, Tilly; Taxis, Katja; van den Bemt, Patricia M. L. A.

    Background: The medication cart can be filled using an automated system or a manual method and when using a manual method the medication can be arranged either by round time or by medication name. For the manual methods, it is hypothesized that the latter method would result in a lower frequency of

  10. Photography as a means of identity representation: from Disdéri visit cards to cyberspace A fotografia como modo de representação da identidade: dos cartões de visita de Disdéri ao ciberespaço

    Directory of Open Access Journals (Sweden)

    Dirce Vasconcellos Lopes

    2007-01-01

    Full Text Available This article discusses the aspects of construction of personal identities through image, from the invention of the carte-de-visite by Disdéri, in 1851, to current days. It analyses the technological developments of image production, of social communication and of information systems and their effects in identity representation. Methods include: literature review, field research and participant observation, fundamental to the analysis of relationship sites: orkut.com and seconlife.com. O artigo aborda os aspectos da construção das identidades pessoais por meio da imagem, da invenção das carte-de-visite por Disdéri, em 1854, aos dias atuais. Analisa os desenvolvimentos tecnológicos da produção imagética, da comunicação social e da informática e seus efeitos na representação da identidade. Os métodos utilizados para sua realização incluem: revisão de literatura, pesquisa de campo e observação-participante, fundamental para a análise dos sites de relacionamento: orkut.com e secondlife.com.

  11. Vous avez dit rock arabe ? Retour sur la trajectoire du groupe Carte de séjour (1980-1989)

    OpenAIRE

    Hanus, Philippe

    2016-01-01

    En 1981, la presse spécialisée consacre le groupe Carte de séjour ambassadeur du « rock arabe ». Cet article retrace la trajectoire d’un ensemble musical à géométrie variable, formé autour de Mohamed Amini et Rachid Taha, dans une banlieue ouvrière lyonnaise. Ces jeunes artistes contestataires inventent une langue nourrie de darja (arabe populaire algérien) de français et matinée d’anglicismes. Il s’agira enfin de monter en quoi leur prise de parole s’inscrit dans les mouvements de lutte pour...

  12. Integral backstepping sliding mode control for underactuated systems: swing-up and stabilization of the Cart-Pendulum System.

    Science.gov (United States)

    Adhikary, Nabanita; Mahanta, Chitralekha

    2013-11-01

    In this paper an integral backstepping sliding mode controller is proposed for controlling underactuated systems. A feedback control law is designed based on backstepping algorithm and a sliding surface is introduced in the final stage of the algorithm. The backstepping algorithm makes the controller immune to matched and mismatched uncertainties and the sliding mode control provides robustness. The proposed controller ensures asymptotic stability. The effectiveness of the proposed controller is compared against a coupled sliding mode controller for swing-up and stabilization of the Cart-Pendulum System. Simulation results show that the proposed integral backstepping sliding mode controller is able to reject both matched and mismatched uncertainties with a chattering free control law, while utilizing less control effort than the sliding mode controller. Copyright © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

  13. Une carte rupestre précolombienne? La modélisation des pétroglyphes mexicains

    Directory of Open Access Journals (Sweden)

    Véronique Darras

    1990-05-01

    Full Text Available Une carte rupestre précolombienne? L'analyse chorématique des pétroglyphes de Las Estacas (Zináparo, Michoacán, Mexique permet cette excitante hypothèse. La modélisation graphique révèle deux structures semi-concentriques opposées, différenciées par leur symbolique interne et associées par un ensemble de signes hiérarchisés et orientés. Nous l'interprétons comme la cartographie d'un événement social qui met en relation deux groupes culturels distincts mais complémentaires.

  14. Evolution of drug resistance in HIV infected patients remaining on a virologically failing cART regimen

    DEFF Research Database (Denmark)

    Cozzi-Lepri, A; Phillips, AN; Ruiz, L

    2007-01-01

    OBJECTIVE: To estimate the extent of drug resistance accumulation in patients kept on a virologically failing regimen and its determinants in the clinical setting. DESIGN: The study focused on 110 patients of EuroSIDA on an unchanged regimen who had two genotypic tests performed at two time points.......08 [95% confidence interval (CI), -2.13 to -0.03; P = 0.04] in those with GSS_f-t0 of 0.5-1.5 and -1.24 (95% CI, -2.44 to -0.04; P = 0.04) in those with GSS_f-t0 >or= 2. CONCLUSIONS: In patients kept on the same virologically failing cART regimen for a median of 6 months, there was considerable...

  15. La géographie de Jules Verne et ses cartes dans L’île mystérieuse

    Directory of Open Access Journals (Sweden)

    Jacky Fontanabona

    2010-05-01

    Full Text Available Destinés à la jeunesse, les Voyages extraordinaires ont une vocation récréative mais aussi éducative. Romancier, Jules Verne veut aussi contribuer à la diffusion d'une géographie de son temps, descriptive, encyclopédique, de plain-pied dans une réalité constituée de «faits avérés». Dans L’île mystérieuse, il subvertit cette dernière règle en narrant la colonisation d’un territoire fictif par des Robinsons. Articulant carte, images et texte littéraire, l'édition illustrée devient alors un système d’expression qui joue du diptyque véracité/véridicité pour inventer une chimère géographique.

  16. Assessing the family dynamics of childhood maltreatment history with the Childhood Attachment and Relational Trauma Screen (CARTS

    Directory of Open Access Journals (Sweden)

    Paul Frewen

    2015-08-01

    Full Text Available Background: Existing survey measures of childhood trauma history generally fail to take into account the relational-socioecological environment in which childhood maltreatment occurs. Variables such as the relationship between the perpetrator and the victim, the emotional availability of caregivers, witnessing the abuse of others, and the respondent's own thoughts, feelings, and actions in response to maltreatment are rarely assessed by current measures. Methods: To address these concerns, the current study further investigated the family dynamics of childhood maltreatment using the Childhood Attachment and Relational Trauma Screen (CARTS in 1,782 persons assessed online. Results: Paired differences in means between item-rated descriptiveness of self, mothers, and fathers suggested that respondents’ relationship with their biological fathers was less positive and secure than their relationship with their biological mothers, and that biological fathers were more often the perpetrator of emotional, physical, and sexual abuse than biological mothers. However, results further suggested that ratings between self, mothers, and fathers were positively correlated such that, for example, reports of a mother's or a respondent's own abusive behavior were more likely in the presence of reports of a father's abusive behavior. In addition, analyses evaluating witnessing violence demonstrated that fathers were rated as more often violent toward mothers than the reverse, although intimate partner violence was also frequently bidirectional. Analyses of sibling ratings further demonstrated that older brothers were either as or more frequently abusive when compared with parents. Finally, results suggested that childhood emotional, physical, and sexual abuse were much more often perpetrated by family members than extra-familial and non-family members. Conclusions: In so far as these findings are consistent with the prior childhood trauma and attachment literature

  17. Influence of Sub-grid-Scale Isentropic Transports on McRAS Evaluations using ARM-CART SCM Datasets

    Science.gov (United States)

    Sud, Y. C.; Walker, G. K.; Tao, W. K.

    2004-01-01

    In GCM-physics evaluations with the currently available ARM-CART SCM datasets, McRAS produced very similar character of near surface errors of simulated temperature and humidity containing typically warm and moist biases near the surface and cold and dry biases aloft. We argued it must have a common cause presumably rooted in the model physics. Lack of vertical adjustment of horizontal transport was thought to be a plausible source. Clearly, debarring such a freedom would force the incoming air to diffuse into the grid-cell which would naturally bias the surface air to become warm and moist while the upper air becomes cold and dry, a characteristic feature of McRAS biases. Since, the errors were significantly larger in the two winter cases that contain potentially more intense episodes of cold and warm advective transports, it further reaffirmed our argument and provided additional motivation to introduce the corrections. When the horizontal advective transports were suitably modified to allow rising and/or sinking following isentropic pathways of subgrid scale motions, the outcome was to cool and dry (or warm and moisten) the lower (or upper) levels. Ever, crude approximations invoking such a correction reduced the temperature and humidity biases considerably. The tests were performed on all the available ARM-CART SCM cases with consistent outcome. With the isentropic corrections implemented through two different numerical approximations, virtually similar benefits were derived further confirming the robustness of our inferences. These results suggest the need for insentropic advective transport adjustment in a GCM due to subgrid scale motions.

  18. Experimental validation of optical layer performance monitoring using an all-optical network testbed

    Science.gov (United States)

    Vukovic, Alex; Savoie, Michel J.; Hua, Heng

    2004-11-01

    Communication transmission systems continue to evolve towards higher data rates, increased wavelength densities, longer transmission distances and more intelligence. Further development of dense wavelength division multiplexing (DWDM) and all-optical networks (AONs) will demand ever-tighter monitoring to assure a specified quality of service (QoS). Traditional monitoring methods have been proven to be insufficient. Higher degree of self-control, intelligence and optimization for functions within next generation networks require new monitoring schemes to be developed and deployed. Both perspective and challenges of performance monitoring, its techniques, requirements and drivers are discussed. It is pointed out that optical layer monitoring is a key enabler for self-control of next generation optical networks. Aside from its real-time feedback and the safeguarding of neighbouring channels, optical performance monitoring ensures the ability to build and control complex network topologies while maintaining an efficiently high QoS. Within an all-optical network testbed environment, key performance monitoring parameters are identified, assessed through real-time proof-of-concept, and proposed for network applications for the safeguarding of neighbouring channels in WDM systems.

  19. Design and Validation of a Software Defined Radio Testbed for DVB-T Transmission

    Directory of Open Access Journals (Sweden)

    G. Baruffa

    2014-04-01

    Full Text Available This paper describes the design and validation of a Software Defined Radio (SDR testbed, which can be used for Digital Television transmission using the Digital Video Broadcasting - Terrestrial (DVB-T standard. In order to generate a DVB-T-compliant signal with low computational complexity, we design an SDR architecture that uses the C/C++ language and exploits multithreading and vectorized instructions. Then, we transmit the generated DVB-T signal in real time, using a common PC equipped with multicore central processing units (CPUs and a commercially available SDR modem board. The proposed SDR architecture has been validated using fixed TV sets, and portable receivers. Our results show that the proposed SDR architecture for DVB-T transmission is a low-cost low-complexity solution that, in the worst case, only requires less than 22% of CPU load and less than 170 MB of memory usage, on a 3.0 GHz Core i7 processor. In addition, using the same SDR modem board, we design an off-line software receiver that also performs time synchronization and carrier frequency offset estimation and compensation.

  20. First experiences with a parallel architecture testbed in the LHCb trigger system

    Science.gov (United States)

    Gallorini, S.; Lucchesi, D.; Gianelle, A.; Amerio, S.; Corvo, M.

    2017-10-01

    In view of Run3 (2020) the LHCb experiment is planning a major upgrade to fully readout events at 40 MHz collision rate. This in order to highly increase the statistic of the collected samples and go further in precision beyond Run2. An unprecedented amount of data will be produced, which will be fully reconstructed real-time to perform fast selection and categorization of interesting events. The collaboration has decided to go for a fully software trigger which will have a total time budget of 13 ms to take a decision. This calls for faster hardware and software. In this talk we will present our efforts on the application of new technologies, such as GPU cards, for the future LHCb trigger system. During Run2 a node equipped with a GPU has been inserted in the LHCb online monitoring system; during normal data taking, a subset of real events is sent to the node and processed in parallel by GPU-based and CPU-based track reconstruction algorithms. This gives us the unique opportunity to test the new hardware and the new algorithms in a realistic environment. We will present the setup of the testbed, the algorithms developed for parallel architectures and discuss the performance compared to the current LHCb track reconstruction algorithms.

  1. Characterisation of a turbulent module for the MITHIC high-contrast imaging testbed

    Science.gov (United States)

    Vigan, A.; Postnikova, M.; Caillat, A.; Sauvage, J.-F.; Dohlen, K.; El Hadi, K.; Fusco, T.; Lamb, M.; N'Diaye, M.

    2016-07-01

    Future high-contrast imagers on ground-based extremely large telescopes will have to deal with the segmentation of the primary mirrors. Residual phase errors coming from the phase steps at the edges of the segments will have to be minimized in order to reach the highest possible wavefront correction and thus the best contrast performance. To study these effects, we have developed the MITHIC high-contrast testbed, which is designed to test various strategies for wavefront sensing, including the Zernike sensor for Extremely accurate measurements of Low-level Differential Aberrations (ZELDA) and COronagraphic Focal-plane wave-Front Estimation for Exoplanet detection (COFFEE). We recently equipped the bench with a new atmospheric turbulence simulation module that offers both static phase patterns representing segmented primary mirrors and continuous phase strips representing atmospheric turbulence filtered by an AO or an XAO system. We present a characterisation of the module using different instruments and wavefront sensors, and the first coronagraphic measurements obtained on MITHIC.

  2. Evaluation of Five Control Algorithms for Addressing CMG Induced Jitter on a Spacecraft Testbed

    Science.gov (United States)

    Ahn, Edwin S.; Longman, Richard W.; Kim, Jae J.; Agrawal, Brij N.

    2013-12-01

    Spacecraft often experience jitter from reaction wheels, control moment gyros (CMGs), or from motion of other internal parts. One may isolate fine pointing equipment by passive techniques, but active vibration control employing knowledge of the periodic nature of jitter can improve performance. Previous work by the authors and co-workers tested active isolation using a 6 degree-of-freedom Stewart platform. A new class of applications is laser communication relay satellites, which replaces radio frequencies communication by laser communications. Laser beam jitter can be corrected by control of tip and tilt in fast steering mirrors. This paper develops experiments testing five candidate jitter cancellation algorithms on the Bifocal Relay Mirror Spacecraft, Three Axis Simulator 2 testbed at the Naval Postgraduate School. Jitter results from the CMGs. Multiple period repetitive control (MPRC) and matched basis function repetitive control (MBFRC) are tested. Both use disturbance period information from Hall effect sensors for the CMG three phase brushless DC motors. Filtered-X LMS, adaptive linear model predictive control, and the Clear Box algorithm with Adaptive Basis Method are also tested. The best disturbance rejection resulted from the last of these choices, with a 66 % overall amplitude reduction. Concerning MPRC it was discovered that repeating an addressed period can be used as a technique to decrease sensitivity to accurate knowledge of the disturbance period.

  3. Networked seduction: a test-bed for the study of strategic communication on the Internet.

    Science.gov (United States)

    Mantovani, F

    2001-02-01

    One of the emerging features of the Internet is its relational and communicative nature: the initial centrality of the information exchange is moving to the building of online relationships, from friendship to romantic and even sexual relationships. The main goal of this paper is to define a theoretical model for the study of seductive processes on the Internet. In particular, taking up the perspective of the user, a shift of focus is proposed: from the description of the development of interpersonal attraction to the investigation of seduction, considered as a strategic communication process. According to the presented model, the key effort of the subjects involved in a computer-mediated seductive interaction is the negotiation of the meaning of the situation they are involved in. This process usually requires two tasks: the analysis of the characteristics of the communicative environment in which the play of interpersonal attraction develops, and the exploitation of the affordances offered by the communicative environment according to specific strategic goals. The main features of the model are both the focus on the communicative tools employed by the users to reach their relational goals, and the ergonomic characteristics of the networked environment. This approach can be used as a test-bed for the definition of specific hypotheses concerning the development of seductive interaction online.

  4. Evaluation of the Second Transport Rotorcraft Airframe Crash Testbed (TRACT 2) Full Scale Crash Test

    Science.gov (United States)

    Annett, Martin; Littell, Justin

    2015-01-01

    Two Transport Rotorcraft Airframe Crash Testbed (TRACT) full-scale tests were performed at NASA Langley Research Center's Landing and Impact Research Facility in 2013 and 2014. Two CH-46E airframes were impacted at 33-ft/s forward and 25-ft/s vertical combined velocities onto soft soil, which represents a severe, but potentially survivable impact scenario. TRACT 1 provided a baseline set of responses, while TRACT 2 included retrofits with composite subfloors and other crash system improvements based on TRACT 1. For TRACT 2, a total of 18 unique experiments were conducted to evaluate ATD responses, seat and restraint performance, cargo restraint effectiveness, patient litter behavior, and activation of emergency locator transmitters and crash sensors. Combinations of Hybrid II, Hybrid III, and ES-2 Anthropomorphic Test Devices (ATDs) were placed in forward and side facing seats and occupant results were compared against injury criteria. The structural response of the airframe was assessed based on accelerometers located throughout the airframe and using three-dimensional photogrammetric techniques. Analysis of the photogrammetric data indicated regions of maximum deflection and permanent deformation. The response of TRACT 2 was noticeably different in the longitudinal direction due to changes in the cabin configuration and soil surface, with higher acceleration and damage occurring in the cabin. Loads from ATDs in energy absorbing seats and restraints were within injury limits. Severe injury was likely for ATDs in forward facing passenger seats.

  5. Overview of the Transport Rotorcraft Airframe Crash Testbed (TRACT) Full Scale Crash Tests

    Science.gov (United States)

    Annett, Martin; Littell, Justin

    2015-01-01

    The Transport Rotorcraft Airframe Crash Testbed (TRACT) full-scale tests were performed at NASA Langley Research Center's Landing and Impact Research Facility in 2013 and 2014. Two CH-46E airframes were impacted at 33-ft/s forward and 25-ft/s vertical combined velocities onto soft soil, which represents a severe, but potentially survivable impact scenario. TRACT 1 provided a baseline set of responses, while TRACT 2 included retrofits with composite subfloors and other crash system improvements based on TRACT 1. For TRACT 2, a total of 18 unique experiments were conducted to evaluate Anthropomorphic Test Devices (ATD) responses, seat and restraint performance, cargo restraint effectiveness, patient litter behavior, and activation of emergency locator transmitters and crash sensors. Combinations of Hybrid II, Hybrid III, and ES-2 ATDs were placed in forward and side facing seats and occupant results were compared against injury criteria. The structural response of the airframe was assessed based on accelerometers located throughout the airframe and using three-dimensional photogrammetric techniques. Analysis of the photogrammetric data indicated regions of maximum deflection and permanent deformation. The response of TRACT 2 was noticeably different in the horizontal direction due to changes in the cabin configuration and soil surface, with higher acceleration and damage occurring in the cabin. Loads from ATDs in energy absorbing seats and restraints were within injury limits. Severe injury was likely for ATDs in forward facing passenger seats.

  6. Computer graphics testbed to simulate and test vision systems for space applications

    Science.gov (United States)

    Cheatham, John B.; Wu, Chris K.; Lin, Y. H.

    1991-01-01

    A system was developed for displaying computer graphics images of space objects and the use of the system was demonstrated as a testbed for evaluating vision systems for space applications. In order to evaluate vision systems, it is desirable to be able to control all factors involved in creating the images used for processing by the vision system. Considerable time and expense is involved in building accurate physical models of space objects. Also, precise location of the model relative to the viewer and accurate location of the light source require additional effort. As part of this project, graphics models of space objects such as the Solarmax satellite are created that the user can control the light direction and the relative position of the object and the viewer. The work is also aimed at providing control of hue, shading, noise and shadows for use in demonstrating and testing imaging processing techniques. The simulated camera data can provide XYZ coordinates, pitch, yaw, and roll for the models. A physical model is also being used to provide comparison of camera images with the graphics images.

  7. Demonstration of symmetric dark holes using two deformable mirrors at the high-contrast imaging testbed

    Science.gov (United States)

    Riggs, A. J. Eldorado; Groff, Tyler D.; Carlotti, Alexis; Kasdin, N. Jeremy; Cady, Eric J.; Kern, Brian D.; Kuhnert, Andreas

    2013-09-01

    The High Contrast Imaging Laboratory (HCIL) at Princeton has developed several important algorithms and technologies for space-based coronagraphy missions to detect earth-like exoplanets. Before June 2013 the HCIL was the only facility with two deformable mirrors (DMs) in series for focal plane wavefront control, which allows for quasi-static speckle correction on both sides of the image plane. From June through August 2013, the High- Contrast Imaging Testbed (HCIT) at JPL had a second DM installed. In this paper we report on the results of our Technology Development for Exoplanet Missions project to achieve high contrast in two symmetric dark holes using a shaped pupil (SP) coronagraph at the HCIT. Our previous experiment with a similar SP at the HCIT in 2007 yielded single-sided dark holes. That experiment utilized an iterative, batch-process wavefront estimator and Electric Field Conjugation for wavefront control. Our current tests use the faster Kalman filter estimator and the stroke minimization control algorithm. We use the same ripple-style SPs as in the previous HCIT experiment because that mask manufacturing technique proved successful. Our tests of symmetric dark holes in monochromatic light at the HCIT demonstrate Princeton's steady improvements in wavefront control and estimation techniques for a space-based coronagraphy mission.

  8. EXTENDED PHOTOMETRY FOR THE DEEP2 GALAXY REDSHIFT SURVEY: A TESTBED FOR PHOTOMETRIC REDSHIFT EXPERIMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Daniel J.; Newman, Jeffrey A. [Department of Physics and Astronomy, University of Pittsburgh, 3941 O' Hara Street, Pittsburgh, PA 15260 (United States); Coil, Alison L. [Department of Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 (United States); Cooper, Michael C. [Center for Galaxy Evolution, Department of Physics and Astronomy, University of California, Irvine, 4129 Frederick Reines Hall, Irvine, CA 92697 (United States); Gwyn, Stephen D. J., E-mail: djm70@pitt.edu, E-mail: janewman@pitt.edu, E-mail: acoil@ucsd.edu, E-mail: m.cooper@uci.edu, E-mail: Stephen.Gwyn@nrc-cnrc.gc.ca [Canadian Astronomical Data Centre, Herzberg Institute of Astrophysics, 5071 West Saanich Road, Victoria, British Columbia V9E 2E7 (Canada)

    2013-02-15

    This paper describes a new catalog that supplements the existing DEEP2 Galaxy Redshift Survey photometric and spectroscopic catalogs with ugriz photometry from two other surveys: the Canada-France-Hawaii Legacy Survey (CFHTLS) and the Sloan Digital Sky Survey (SDSS). Each catalog is cross-matched by position on the sky in order to assign ugriz photometry to objects in the DEEP2 catalogs. We have recalibrated the CFHTLS photometry where it overlaps DEEP2 in order to provide a more uniform data set. We have also used this improved photometry to predict DEEP2 BRI photometry in regions where only poorer measurements were available previously. In addition, we have included improved astrometry tied to SDSS rather than USNO-A2.0 for all DEEP2 objects. In total this catalog contains {approx}27, 000 objects with full ugriz photometry as well as robust spectroscopic redshift measurements, 64% of which have r > 23. By combining the secure and accurate redshifts of the DEEP2 Galaxy Redshift Survey with ugriz photometry, we have created a catalog that can be used as an excellent testbed for future photo-z studies, including tests of algorithms for surveys such as LSST and DES.

  9. A test-bed for optimizing high-resolution single particle reconstructions.

    Science.gov (United States)

    Stagg, Scott M; Lander, Gabriel C; Quispe, Joel; Voss, Neil R; Cheng, Anchi; Bradlow, Henry; Bradlow, Steven; Carragher, Bridget; Potter, Clinton S

    2008-07-01

    It is becoming routine for cryoEM single particle reconstructions to result in 3D electron density maps with resolutions of approximately 10A, but maps with resolutions of 5A or better are still celebrated events. The electron microscope has a resolving power to better than 2A, and thus should not be a limiting factor; instead the practical limitations in resolution most likely arise from a combination of specimen preparation methods, data collection parameters, and data analysis procedures. With the aid of a highly automated system for acquiring images, coupled to a relational database to keep track of all processing parameters, we have taken a systematic approach to optimizing parameters affecting the resolution of single particle reconstructions. Using GroEL as a test-bed, we performed a series of 3D reconstructions where we systematically varied the number of particles used in computing the map, the accelerating voltage of the microscope, and the electron dose used to acquire the images. We also investigated methods for excluding unacceptable or "bad" particles from contributing to the final 3D map. Using relatively standard instrumentation (Tecnai F20, 4K x 4K CCD, side entry cold stage) and a completely automated approach, these approaches resulted in a map with a nominal resolution of 5.4A (FSC(0.5)) in which secondary structure is clearly discernable and the handedness of some of the alpha-helices in the GroEL structure can be determined.

  10. Energy Conversion Loop: A Testbed for Nuclear Hybrid Energy Systems Use in Biomass Pyrolysis

    Science.gov (United States)

    Verner, Kelley M.

    Nuclear hybrid energy systems are a possible solution for contemporary energy challenges. Nuclear energy produces electricity without greenhouse gas emissions. However, nuclear power production is not as flexible as electrical grids demand and renewables create highly variable electricity. Nuclear hybrid energy systems are able to address both of these problems. Wasted heat can be used in processes such as desalination, hydrogen production, or biofuel production. This research explores the possible uses of nuclear process heat in bio-oil production via biomass pyrolysis. The energy conversion loop is a testbed designed and built to mimic the heat from a nuclear reactor. Small scale biomass pyrolysis experiments were performed and compared to results from the energy conversion loop tests to determine future pyrolysis experimentation with the energy conversion loop. Further improvements must be made to the energy conversion loop before more complex experiments may be performed. The current conditions produced by the energy conversion loop are not conducive for current biomass pyrolysis experimentation.tion.

  11. Design of a Loose Part Monitoring System Test-bed using CompactRIO

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min-seok; Lee, Kwang-Dae; Lee, Eui-Jong [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    A loose part monitoring system (LPMS) is included in the NSSS integrity monitoring system (NIMS), which serves to detect loose parts in reactor coolant systems (RCS). LPMSs at Nuclear Power Plants (NPPs) in Korea follow the ASME OM standard and acquire data from 18 sensors simultaneously. Data acquisition requires a sampling rate of more than 50KHz along with a 12bit A/D converter. Existing LPMS equipment is composed of several different platforms, such as a digital signal processor (DSP), a field-programmable gate array (FPGA), a micro control unit (MCU), and electric circuit cards. These systems have vulnerabilities, such as discontinuance due to aging and incompatibility issues between different pieces of equipment. This paper suggests CompactRIO as a new platform. We devised a Test-bed using CompactRIO and demonstrate that the proposed method meets the criteria required by the standard. The LPMS provides an alert when an impact event occurs and provides information with which to analyze the location, energy, and mass of the loose parts. LPMSs in NPPs in Korea operate on a variety of platforms. Thus, these systems are vulnerable to discontinuances due to aging and incompatibilities arising from the use of different type of equipment. In order to solve these problems, this paper suggests CompactRIO as a new platform. It is a rugged, reconfigurable, high-performance industrial embedded system. The results of performance tests meet the criteria set by the current standard.

  12. A Rural Next Generation Network (R-NGN and Its Testbed

    Directory of Open Access Journals (Sweden)

    Armein Z. R. Langi

    2013-09-01

    Full Text Available Rural Next Generation Networks (R-NGN technology allows Internet protocol (IP based systems to be used in rural areas. This paper reports a testbed of R-NGN that uses low cost Ethernet radio links, combined with media gateways and a softswitch. The network consists of point-to-point IP Ethernet 2.4 GHz wireless link, IP switches and gateways in each community, standard copper wires and telephone sets for users. It uses low power consumption, and suitable for low density users. This combination allows low cost systems as well as multiservices (voice, data, and multimedia for rural communications. An infrastructure has been deployed in two communities in Cipicung Girang, a village 10 km outside Bandung city, Indonesia. Two towers link the communities with a network of Institut Teknologi Bandung (ITB campus. In addition, local wirelines connect community houses to the network. Currently there are four houses connected to each community node (for a total of eight house, upon which we can perform various tests and measurements.

  13. A Rural Next Generation Network (R-NGN and Its Testbed

    Directory of Open Access Journals (Sweden)

    Armein Z. R. Langi

    2007-05-01

    Full Text Available Rural Next Generation Networks (R-NGN technology allows Internet protocol (IP based systems to be used in rural areas. This paper reports a testbed of R-NGN that uses low cost Ethernet radio links, combined with media gateways and a softswitch. The network consists of point-to-point IP Ethernet 2.4 GHz wireless link, IP switches and gateways in each community, standard copper wires and telephone sets for users. It uses low power consumption, and suitable for low density users. This combination allows low cost systems as well as multiservices (voice, data, and multimedia for rural communications. An infrastructure has been deployed in two communities in Cipicung Girang, a village 10 km outside Bandung city, Indonesia. Two towers link the communities with a network of Institut Teknologi Bandung (ITB campus. In addition, local wirelines connect community houses to the network. Currently there are four houses connected to each community node (for a total of eight house, upon which we can perform various tests and measurements.

  14. Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research

    Directory of Open Access Journals (Sweden)

    Kanako Inoo

    2016-01-01

    Full Text Available We previously reported that tumor vessel-redirected T cells, which were genetically engineered with chimeric antigen receptor (CAR specific for vascular endothelial growth factor receptor 2 (VEGFR2, demonstrated significant antitumor effects in various murine solid tumor models. In the present study, we prepared anti-VEGFR2 CAR-T cells by CAR-coding mRNA electroporation (mRNA-EP and analyzed their immunological characteristics and functions for use in clinical research. The expression of anti-VEGFR2 CAR on murine and human T cells was detected with approximately 100% efficiency for a few days, after peaking 6–12 hours after mRNA-EP. Triple transfer of murine anti-VEGFR2 CAR-T cells into B16BL6 tumor-bearing mice demonstrated an antitumor effect comparable to that for the single transfer of CAR-T cells engineered with retroviral vector. The mRNA-EP did not cause any damage or defects to human T-cell characteristics, as determined by viability, growth, and phenotypic parameters. Additionally, two kinds of human anti-VEGFR2 CAR-T cells, which expressed different CAR construction, differentiated to effector phase with cytokine secretion and cytotoxic activity in antigen-specific manner. These results indicate that our anti-VEGFR2 CAR-T cells prepared by mRNA-EP have the potential in terms of quality and performance to offer the prospect of safety and efficacy in clinical research as cellular medicine.

  15. ELECTROPHYSIOLOGICAL CHARACTERISTICS OF PARAVENTRICULAR THALAMIC (PVT NEURONS IN RESPONSE TO CHRONIC COCAINE EXPOSURE: EFFECTS OF COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT (CART

    Directory of Open Access Journals (Sweden)

    Jiann Wei eYeoh

    2014-08-01

    Full Text Available Recent work has established that the paraventricular thalamus (PVT is a central node in the brain reward-seeking pathway. This role is likely mediated in part through the dense projections to the PVT from hypothalamic peptide transmitter systems such as orexin, and cocaine- and amphetamine-regulated transcript (CART, both of which play key roles in drug-seeking behaviour. Consistent with this proposition, we previously found that inactivation of the PVT or infusions of CART into the PVT suppressed drug-seeking behaviour in an animal model of contingent cocaine self-administration. Despite this work, very few studies have assessed the basic physiological properties of PVT neurons and how these parameters are altered by exposure to drugs such as cocaine. We set out to address these questions by employing an electrophysiological approach to record from anterior PVT (aPVT neurons from cocaine-treated and control animals. First, we determined the excitability of aPVT neurons by injecting a series of depolarizing current steps and characterizing the resulting action potential (AP discharge properties. Second, we investigated the effects of CART on excitatory synaptic inputs to aPVT neurons. We found that the majority of aPVT neurons exhibited tonic firing (TF, and initial bursting (IB consistent with previous studies. However, we also identified PVT neurons that exhibited delayed firing (DF, single spiking (SS and reluctant firing (RF. Interestingly, cocaine exposure shifted the proportion of aPVT neurons that exhibited TF. Further, application of CART suppressed excitatory synaptic drive to PVT. This finding is consistent with our previous behavioural data, which showed that CART signaling in the PVT negatively regulates drug-seeking behaviour. Together, these studies support previous anatomical evidence that the PVT can integrate reward-relevant information and provides a putative mechanism through which drugs of abuse can dysregulate this system in

  16. Magnetic Resonance Imaging Characterization and Clinical Outcomes After NeoCart Surgical Therapy as a Primary Reparative Treatment for Knee Cartilage Injuries.

    Science.gov (United States)

    Anderson, Devon E; Williams, Riley J; DeBerardino, Thomas M; Taylor, Dean C; Ma, C Benjamin; Kane, Marie S; Crawford, Dennis C

    2017-03-01

    Autologous cartilage tissue implants, including the NeoCart implant, are intended to repair focal articular cartilage lesions. Short-term results from United States Food and Drug Administration (FDA) phase I and phase II clinical trials indicated that the NeoCart implant was safe when surgically applied as a cell-based therapy and efficacious compared with microfracture. Quantitative magnetic resonance imaging (MRI) analysis would reveal NeoCart tissue maturation through to 60-month follow-up. Case series; Level of evidence, 4. Patients with symptomatic full-thickness cartilage lesions of the distal femoral condyle were treated with NeoCart in FDA clinical trials. Safety and efficacy were evaluated prospectively by MRI and clinical patient-reported outcomes (PROs) through to 60-month follow-up. Qualitative MRI metrics were quantified according to modified MOCART (magnetic resonance observation of cartilage repair tissue) criteria, with an independent evaluation of repair tissue signal intensity. Subjective PROs and objective range of motion (ROM) were obtained at baseline and through to 60 months. Twenty-nine patients treated with NeoCart were observed over a mean of 52.0 ± 15.5 months (median, 60 months). MOCART analyses indicated significant improvement ( P cartilage quality from 3 to 24 months, with stabilization from 24 to 60 months. Signal intensity of the repair tissue evolved from hyperintense at early follow-up to isointense after 6 months and to hypointense after 24 months. The temporal progression toward hypointense T2 signals at later time points observed here indicated a further reorganization of the repair tissue toward a dense tissue that was less similar to the surrounding native tissue. However, 80% of patients showed evidence of subchondral bone changes on MRI at all time points; 4 patients (14%) showed no improvement of MRI criteria. Compared with baseline values, significant improvement ( P cartilage lesions through to 5-year follow

  17. « À la recherche des Macédoniens » : le regard des cartes, 1840-1918

    Directory of Open Access Journals (Sweden)

    Joëlle Dalègre

    2011-12-01

    Full Text Available Comment peu à peu les cartes ethnographiques découvrent et signalent, en Macédoine, à l’aube du XXe siècle, des « Macédoniens slaves »L’expression « péninsule balkanique » est employée pour la première fois en 1808 par August Zeune, en 1821, un autre Allemand, d’Oetzel, dessine la première carte des populations européennes. Les cartes se multiplient jusqu’en 1920. Peu à peu se précisent les techniques, la connaissance des régions et des populations ; les cartes deviennent une arme de propagande, attribuant, selon le concepteur, le territoire macédonien aux Grecs, aux Serbes et majoritairement aux Bulgares. Le Serbe Cvijic, en 1906, le premier, situe sur une carte, des « macédoslaves ». Cette communication présente les étapes principales de cette évolution cartographique qui aboutit à découvrir des « Macédoniens » en… Macédoine.The expression ’Balkan peninsula’ was first employed in 1808 by August Zeune. In 1821 another German, d’Oetzel, drew the first map of the European populations. The maps continued multiplying until 1920. Little by little the techniques as well as the knowledge of the various regions and populations became more precise. The maps became a propaganda tool, in as much as they attributed—depending on the cartographer—Macedonian territory to the Greeks, the Serbs or, most often, the Bulgarians. In 1906, the Serb Cvijic, the first, situated on a map, the “macédoslaves”. This communication outlines the principal stages of this cartographic evolution, which eventually situated the “Macedonians” in none other than… Macedonia.

  18. Réduction à 1/2 500 000 de la Carte géomorphologique de la France 1/1000 000. Généralisation et utilisation

    Directory of Open Access Journals (Sweden)

    Fernand JOLY

    1988-06-01

    Full Text Available Réduction à 1/2 500 000 des deux feuilles NW et NE de la Carte géomorphologique de la France à 1/1 000 000 à partir des fichiers de zones lithologiques et de formations superficielles et d'une réduction photographique des formes. Principes d'aménagement de la légende. Perspectives d'utilisation comme carte d'atlas, comme base de données pour d'autres cartes et comme source sélective de documentation.

  19. James Webb Space Telescope optical simulation testbed IV: linear control alignment of the primary segmented mirror

    Science.gov (United States)

    Egron, Sylvain; Soummer, Rémi; Lajoie, Charles-Philippe; Bonnefois, Aurélie; Long, Joseph; Michau, Vincent; Choquet, Elodie; Ferrari, Marc; Leboulleux, Lucie; Levecq, Olivier; Mazoyer, Johan; N'Diaye, Mamadou; Perrin, Marshall; Petrone, Peter; Pueyo, Laurent; Sivaramakrishnan, Anand

    2017-09-01

    The James Webb Space Telescope (JWST) Optical Simulation Testbed (JOST) is a tabletop experiment designed to study wavefront sensing and control for a segmented space telescope, such as JWST. With the JWST Science and Operations Center co-located at STScI, JOST was developed to provide both a platform for staff training and to test alternate wavefront sensing and control strategies for independent validation or future improvements beyond the baseline operations. The design of JOST reproduces the physics of JWST's three-mirror anastigmat (TMA) using three custom aspheric lenses. It provides similar quality image as JWST (80% Strehl ratio) over a field equivalent to a NIRCam module, but at 633 nm. An Iris AO segmented mirror stands for the segmented primary mirror of JWST. Actuators allow us to control (1) the 18 segments of the segmented mirror in piston, tip, tilt and (2) the second lens, which stands for the secondary mirror, in tip, tilt and x, y, z positions. We present the most recent experimental results for the segmented mirror alignment. Our implementation of the Wavefront Sensing (WFS) algorithms using phase diversity is tested on simulation and experimentally. The wavefront control (WFC) algorithms, which rely on a linear model for optical aberrations induced by misalignment of the secondary lens and the segmented mirror, are tested and validated both on simulations and experimentally. In this proceeding, we present the performance of the full active optic control loop in presence of perturbations on the segmented mirror, and we detail the quality of the alignment correction.

  20. Photovoltaic Shading Testbed for Module-Level Power Electronics: 2016 Performance Data Update

    Energy Technology Data Exchange (ETDEWEB)

    Deline, Chris [National Renewable Energy Lab. (NREL), Golden, CO (United States); Meydbray, Jenya [PV Evolution Labs (PVEL), Davis, CA (United States); Donovan, Matt [PV Evolution Labs (PVEL), Davis, CA (United States)

    2016-09-01

    The 2012 NREL report 'Photovoltaic Shading Testbed for Module-Level Power Electronics' provides a standard methodology for estimating the performance benefit of distributed power electronics under partial shading conditions. Since the release of the report, experiments have been conducted for a number of products and for different system configurations. Drawing from these experiences, updates to the test and analysis methods are recommended. Proposed changes in data processing have the benefit of reducing the sensitivity to measurement errors and weather variability, as well as bringing the updated performance score in line with measured and simulated values of the shade recovery benefit of distributed PV power electronics. Also, due to the emergence of new technologies including sub-module embedded power electronics, the shading method has been extended to include power electronics that operate at a finer granularity than the module level. An update to the method is proposed to account for these emerging technologies that respond to shading differently than module-level devices. The partial shading test remains a repeatable test procedure that attempts to simulate shading situations as would be experienced by typical residential or commercial rooftop photovoltaic (PV) systems. Performance data for multiple products tested using this method are discussed, based on equipment from Enphase, Solar Edge, Maxim Integrated and SMA. In general, the annual recovery of shading losses from the module-level electronics evaluated is 25-35%, with the major difference between different trials being related to the number of parallel strings in the test installation rather than differences between the equipment tested. Appendix D data has been added in this update.