Alloy development for irradiation performance. Quarterly progress report for period ending December 31, 1980

Energy Technology Data Exchange (ETDEWEB)

1981-04-01

Progress is reported in eight sections: analysis and evaluation studies, test matrices and test methods development, Path A Alloy Development (austenitic stainless steels), Path C Alloy Development (Ti and V alloys), Path D Alloy Development (Fe alloys), Path E Alloy Development (ferritic steels), irradiation experiments and materials inventory, and materials compatibility and hydrogen permeation studies. (DLC)

Individual moral development and moral progress

NARCIS (Netherlands)

Schinkel, Anders; de Ruyter, Doret J.

At first glance, one of the most obvious places to look for moral progress is in individuals, in particular in moral development from childhood to adulthood. In fact, that moral progress is possible is a foundational assumption of moral education. Beyond the general agreement that moral progress is

Individual Moral Development and Moral Progress

NARCIS (Netherlands)

Schinkel, Anders; de Ruyter, Doret J.

2017-01-01

At first glance, one of the most obvious places to look for moral progress is in individuals, in particular in moral development from childhood to adulthood. In fact, that moral progress is possible is a foundational assumption of moral education. Beyond the general agreement that moral progress is

Progress report on fast breeder reactor development in Japan, July - September 1977

International Nuclear Information System (INIS)

1978-06-01

As for the experimental fast breeder reactor ''Joyo'', the low power performance tests have been continued, and the measurements of reactor noise, the reactivity of fuel assemblies, power distribution and Na-void effect have been made. Efforts have been exerted to develop the required maintenance equipments, to manufacture the transfer rotor maintenance facilities, and to construct the spent fuel storing and cooling facilities. The analysis and calculation of the core characteristics have been in progress. The design work on the prototype fast breeder reactor ''Monju'' has been continued, and the development of the computer codes for the design has progressed. Informations have been gathered regarding the technological developments of LMFBRs overseas. The surveys on the site for ''Monju'' have been carried out. The design and research works on the demonstration reactor were started, and the general design factors such as the steam condition and the plant layout have been studied. As for the research and development of reactor physics, structural components, instrumentation and control, sodium technology, fuel materials, structural materials, safety, and steam generators, the progresses are reported in detail. High performance neutron detectors for nuclear instrumentation have been under development, and the tagging gas method for fuel failure detection and location system has been tested. (Kako, I.)

Developing and Validating a Predictive Model for Stroke Progression

Directory of Open Access Journals (Sweden)

L.E. Craig

2011-12-01

Full Text Available Background: Progression is believed to be a common and important complication in acute stroke, and has been associated with increased mortality and morbidity. Reliable identification of predictors of early neurological deterioration could potentially benefit routine clinical care. The aim of this study was to identify predictors of early stroke progression using two independent patient cohorts. Methods: Two patient cohorts were used for this study – the first cohort formed the training data set, which included consecutive patients admitted to an urban teaching hospital between 2000 and 2002, and the second cohort formed the test data set, which included patients admitted to the same hospital between 2003 and 2004. A standard definition of stroke progression was used. The first cohort (n = 863 was used to develop the model. Variables that were statistically significant (p 0.1 in turn. The second cohort (n = 216 was used to test the performance of the model. The performance of the predictive model was assessed in terms of both calibration and discrimination. Multiple imputation methods were used for dealing with the missing values. Results: Variables shown to be significant predictors of stroke progression were conscious level, history of coronary heart disease, presence of hyperosmolarity, CT lesion, living alone on admission, Oxfordshire Community Stroke Project classification, presence of pyrexia and smoking status. The model appears to have reasonable discriminative properties [the median receiver-operating characteristic curve value was 0.72 (range 0.72–0.73] and to fit well with the observed data, which is indicated by the high goodness-of-fit p value [the median p value from the Hosmer-Lemeshow test was 0.90 (range 0.50–0.92]. Conclusion: The predictive model developed in this study contains variables that can be easily collected in practice therefore increasing its usability in clinical practice. Using this analysis approach, the

Developing and validating a predictive model for stroke progression.

Science.gov (United States)

Craig, L E; Wu, O; Gilmour, H; Barber, M; Langhorne, P

2011-01-01

Progression is believed to be a common and important complication in acute stroke, and has been associated with increased mortality and morbidity. Reliable identification of predictors of early neurological deterioration could potentially benefit routine clinical care. The aim of this study was to identify predictors of early stroke progression using two independent patient cohorts. Two patient cohorts were used for this study - the first cohort formed the training data set, which included consecutive patients admitted to an urban teaching hospital between 2000 and 2002, and the second cohort formed the test data set, which included patients admitted to the same hospital between 2003 and 2004. A standard definition of stroke progression was used. The first cohort (n = 863) was used to develop the model. Variables that were statistically significant (p p > 0.1) in turn. The second cohort (n = 216) was used to test the performance of the model. The performance of the predictive model was assessed in terms of both calibration and discrimination. Multiple imputation methods were used for dealing with the missing values. Variables shown to be significant predictors of stroke progression were conscious level, history of coronary heart disease, presence of hyperosmolarity, CT lesion, living alone on admission, Oxfordshire Community Stroke Project classification, presence of pyrexia and smoking status. The model appears to have reasonable discriminative properties [the median receiver-operating characteristic curve value was 0.72 (range 0.72-0.73)] and to fit well with the observed data, which is indicated by the high goodness-of-fit p value [the median p value from the Hosmer-Lemeshow test was 0.90 (range 0.50-0.92)]. The predictive model developed in this study contains variables that can be easily collected in practice therefore increasing its usability in clinical practice. Using this analysis approach, the discrimination and calibration of the predictive model appear

Developing and Validating a Predictive Model for Stroke Progression

Science.gov (United States)

Craig, L.E.; Wu, O.; Gilmour, H.; Barber, M.; Langhorne, P.

2011-01-01

Background Progression is believed to be a common and important complication in acute stroke, and has been associated with increased mortality and morbidity. Reliable identification of predictors of early neurological deterioration could potentially benefit routine clinical care. The aim of this study was to identify predictors of early stroke progression using two independent patient cohorts. Methods Two patient cohorts were used for this study – the first cohort formed the training data set, which included consecutive patients admitted to an urban teaching hospital between 2000 and 2002, and the second cohort formed the test data set, which included patients admitted to the same hospital between 2003 and 2004. A standard definition of stroke progression was used. The first cohort (n = 863) was used to develop the model. Variables that were statistically significant (p 0.1) in turn. The second cohort (n = 216) was used to test the performance of the model. The performance of the predictive model was assessed in terms of both calibration and discrimination. Multiple imputation methods were used for dealing with the missing values. Results Variables shown to be significant predictors of stroke progression were conscious level, history of coronary heart disease, presence of hyperosmolarity, CT lesion, living alone on admission, Oxfordshire Community Stroke Project classification, presence of pyrexia and smoking status. The model appears to have reasonable discriminative properties [the median receiver-operating characteristic curve value was 0.72 (range 0.72–0.73)] and to fit well with the observed data, which is indicated by the high goodness-of-fit p value [the median p value from the Hosmer-Lemeshow test was 0.90 (range 0.50–0.92)]. Conclusion The predictive model developed in this study contains variables that can be easily collected in practice therefore increasing its usability in clinical practice. Using this analysis approach, the discrimination and

Development of testing techniques for mine fan performance

Institute of Scientific and Technical Information of China (English)

WU Zheng-yan; JIANG Shu-guang; PENG Dan-ren

2006-01-01

Three progressive stages of testing techniques are elaborated, which are entirely manual operating, taking separate instruments testing and computer program controlling. The testing method and principle are detailed based on the testing process for meteorological parameters, air pressure, air quality and rotating velocity. And every testing technique is analyzed. Finally, the technique outlook is viewed. All this plays a leading role in development of the testing techniques.

The progress test of medicine: the Dutch experience

NARCIS (Netherlands)

Tio, R.A.; Schutte, B.; Meiboom, A.A.; Greidanus, J.; Dubois, E.A.; Bremers, A.J.

2016-01-01

Progress testing in the Netherlands has a long history. It was first introduced at one medical school which had a problem-based learning (PBL) curriculum from the start. Later, other schools with and without PBL curricula joined. At present, approximately 10,000 students sit a test every three

Overview of the Last Progresses for the European Test Blanket Modules Projects

International Nuclear Information System (INIS)

Salavy, J.-F.; Rampal, G.; Boccaccini, L.V.; Meyder, R.; Neuberger, H.; Laesser, R.; Poitevin, Y.; Zmitko, M.; Rigal, E.

2006-01-01

The long-term objective of the EU Breeding Blankets programme is the development of DEMO breeding blankets, which shall assure tritium self-sufficiency, an economically attractive use of the heat produced inside the blankets for electricity generation and a sufficiently high shielding of the superconducting magnets for long time operation. In the short-term so-called DEMO relevant Test Blanket Modules (TBMs) of these breeder blanket concepts shall be designed, manufactured, tested, installed, commissioned and operated in ITER for first tests in a fusion environment. The Helium Cooled Lithium-Lead (HCLL) breeder blanket and the Helium Cooled Pebble Bed (HCPB) concepts are the two breeder blanket lines presently developed by the EU. The main objective of the EU test strategy related to TBMs in ITER is to provide the necessary information for the design and fabrication of breeding blankets for a future DEMO reactor. EU TBMs shall therefore use the same structural and functional materials, apply similar fabrication technologies, and test adequate processes and components. This paper gives an overview of the last progresses in terms of system design, calculations, test program, safety and R-and-D done these last two years in order to cope with the ambitious objective to introduce two EU TBM systems for day-1 of ITER operation. The engineering design of the two systems is mostly concluded and the priority is now on the development and qualification of the fabrication technologies. From calculations point of view, the last modelling efforts related to the thermal-hydraulic of the first wall, the tritium behaviour, and the box thermal and mechanical resistance in accidental conditions are presented. Last features of the TBM and cooling system designs and integration in ITER reactor are highlighted. In particular, this paper also describes the safety and licensing analyses performed for each concept to be able to include the TBM systems in the ITER preliminary safety report

Flexible electronic feedback using the virtues of progress testing

NARCIS (Netherlands)

Muijtjens, A.M.; Timmermans, I.; Donkers, J.; Peperkamp, R.; Medema, H.; Cohen-Schotanus, J.; Thoben, A.; Wenink, A.C.; van der Vleuten, C.P.

2010-01-01

The potential richness of the feedback for learners and teachers is one of the educational advantages of progress tests (PTs). Every test administration yields information on a student's knowledge level in each sub-domain of the test (cross-sectional information), and it adds a next point to the

Influence of PBL with open-book tests on knowledge retention measured with progress tests

NARCIS (Netherlands)

Heijne-Penninga, M.; Kuks, J. B. M.; Hofman, W. H. A.; Muijtjens, A. M. M.; Cohen-Schotanus, J.

The influence of problem-based learning (PBL) and open-book tests on long-term knowledge retention is unclear and subject of discussion. Hypotheses were that PBL as well as open-book tests positively affect long-term knowledge retention. Four progress test results of fifth and sixth-year medical

ATTAP/AGT101 - Year 2 progress in ceramic technology development

Science.gov (United States)

Kidwell, J. R.; Lindberg, L. J.; Morey, R. E.

1990-01-01

The progress made by the Advanced Turbine Technology Applications Project (ATTAP) is summarized, with emphasis on the following areas: ceramic materials assessment and characterization, ceramic impact damage assessment, ceramic combustor evaluation, turbine inlet particle separator development, impact-tolerant turbine designs, and net-shape ceramic component fabrications. In the evolutionary ceramics development in the Automotive Gas Turbine (AGT101) and ATTAP programs initial designs were conceived to reduce stresses by using well-established criteria: bodies of revolution were preferred over nonaxisymmetric geometries, sharp corners were avoided, the contact area between components was kept as large as possible, and small parts were preferred over large when feasible. Projects discussed include: initial ceramic component fabrication by ceramic suppliers in 1990, engine test to 1371 C in 1991, 100-hr test bed engine durability test in 1991, and 300-hr test bed engine durability in 1992.

Progress in Developing Finite Element Models Replicating Flexural Graphite Testing

International Nuclear Information System (INIS)

Bratton, Robert

2010-01-01

This report documents the status of flexural strength evaluations from current ASTM procedures and of developing finite element models predicting the probability of failure. This work is covered under QLD REC-00030. Flexural testing procedures of the American Society for Testing and Materials (ASTM) assume a linear elastic material that has the same moduli for tension and compression. Contrary to this assumption, graphite is known to have different moduli for tension and compression. A finite element model was developed and demonstrated that accounts for the difference in moduli tension and compression. Brittle materials such as graphite exhibit significant scatter in tensile strength, so probabilistic design approaches must be used when designing components fabricated from brittle materials. ASTM procedures predicting probability of failure in ceramics were compared to methods from the current version of the ASME graphite core components rules predicting probability of failure. Using the ASTM procedures yields failure curves at lower applied forces than the ASME rules. A journal paper was published in the Journal of Nuclear Engineering and Design exploring the statistical models of fracture in graphite.

Progress report on pre-test calculations for the large block test

International Nuclear Information System (INIS)

Lee, K.H.

1995-01-01

The U.S. Department of Energy's (DOE) Yucca Mountain Site Characterization Project (YMP) is investigating the suitability of the Topopah Spring tuff in the thick vadose zone at Yucca Mountain, Nevada, as a host rock for permanent disposal of high-level radioactive waste. As part of the YMP, a group of field tests, referred to as the Large Block Test (LBT), will be conducted on a large electrically heated block of Topopah Spring tuff, isolated at Fran Ridge, Nevada Test Site. The block, which will be 3 x 3 m in horizontal dimensions and 4.5 m in height, will be heated by electrical heaters. The goals of the LBT axe to gain information on the coupled thermal-mechanical-hydrological-chemical processes active in the near-field environment of a repository; to provide field data for testing and calibrating models; and to help the development of measurement systems and techniques. This progress report presents results of on-going numerical modeling calculations carried out in support of the LBT design. An equivalent continuum model with an upper boundary temperature of 60 degrees C was used to simulate the hydrothermal response of the block to heating over a one-year period. The total heating power was started at 1500 W and later reduced to maintain an approximately uniform temperature of 138-140 degrees C. For a homogeneous bulk permeability case, the results show the formation of a distinct dry-out zone in and around the heater plane, and well-developed condensation zones above and below the heater plane. For a heterogeneous permeability distribution, the condensation zone above the heater plane was not well developed. This difference in results suggests that water saturation changes might be sensitive to changes in bulk permeability distribution. Rock temperatures were almost unaffected by permeability distribution. Heat flow was dominated by conduction. No liquid flow through the top of the block was predicted

LIFE: Recent Developments and Progress

International Nuclear Information System (INIS)

Anklam, T.M.

2011-01-01

Test results from the NIF show excellent progress toward achieving ignition. Experiments designed to verify coupling of the laser energy to the fusion target have shown that the efficiency meets that needed for ignition. Several tests with the cryogenic targets needed for ignition have been performed, and world-record neutron output produced. The National Ignition Campaign is on schedule to meet its 2012 ignition milestone, with the next phase in the campaign due to start later this month. It has been a busy and very productive year. The NIF is in full 24/7 operations and has progressed markedly in the path toward ignition. The long-standing goal of the National Ignition Campaign to demonstrate ignition by the end of FY 2012 is on track. The LIFE plant design has matured considerably, and a delivery plan established based on close interactions with vendors. National-level reviews of fusion are underway, and are due to present initial findings later this year. A value proposition has been drafted for review. The LIFE project is ready to move into the delivery phase.

A case of natalizumab-associated progressive multifocal leukoencephalopathy with repeated negative CSF JCV testing.

Science.gov (United States)

Mazda, Monica E; Brosch, Jared R; Wiens, Andrea L; Bonnin, José M; Kamer, Aaron P; Mattson, David H; Snook, Riley J

2013-05-01

The development of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab is a well-known potential risk. Diagnosis of PML can be confounded in patients with multiple sclerosis (MS) if new demyelinating lesions develop, and the sensitivity of existing diagnostic tests is less than ideal. In the case presented here, four samples of cerebrospinal fluid tested negative for John Cunningham virus (JCV) DNA by polymerase chain reaction, yet brain biopsy eventually proved positive by immunohistochemistry. A review of the limitations of existing clinical diagnostic tests is addressed, and we review the most recent literature on the proper management of natalizumab-treated MS patients.

NRC review of passive reactor design certification testing programs: Overview, progress, and regulatory perspective

Energy Technology Data Exchange (ETDEWEB)

Levin, A.E.

1995-09-01

New reactor designs, employing passive safety systems, are currently under development by reactor vendors for certification under the U.S. Nuclear Regulatory Commission`s (NRC`s) design certification rule. The vendors have established testing programs to support the certification of the passive designs, to meet regulatory requirements for demonstration of passive safety system performance. The NRC has, therefore, developed a process for the review of the vendors` testing programs and for incorporation of the results of those reviews into the safety evaluations for the passive plants. This paper discusses progress in the test program reviews, and also addresses unique regulatory aspects of those reviews.

Progress report on fast breeder reactor development in Japan

International Nuclear Information System (INIS)

1976-05-01

Following the completion of the in-argon, high temperature test, the in-sodium functional test of Joyo has set in. The fabrication of the equipments for monitoring the flow rate and temperature in the center channel and the power distribution was finished. The modification of design of the prototype fast breeder reactor Monju came into its phase 3. The interim report on the check-up and review of the Monju project by the Government is now ready. Various calculation codes were developed or are in development stage. The mock-up assembly FCA 7-1 has been built, which consists of the Pu-fueled sector region simulating the Monju core and the U-235-fueled driver region. Various reactor physics experiments have been carried out in this assembly. Also, the calculation methods for reactor physics parameters have been developed, and the detailed calculation on the main shield of Joyo was performed. The situation of the developments of the components for Joyo and Monju and the measuring and control systems is shown. Almost all the existing sodium test facilities in Oarai Engineering Center were in service without any trouble, and the new test facility named ''Carbon transfer test loop'' was commissioned. The progress in the fields of sodium technology, fuel and material, safety and steam generators is reported. (Kako, I.)

Progress in MELCOR development and assessment

International Nuclear Information System (INIS)

Summers, R.M.; Kmetyk, L.N.; Cole, R.K. Jr.; Smith, R.C.; Elsbernd, A.E.; Stuart, D.S.; Thompson, S.L.

1995-01-01

MELCOR models the progression of severe accidents in light water reactor nuclear power plants. Recent efforts in MELCOR development to incorporate CORCON-Mod3 models for core-concrete interactions, new models for advanced reactors, and improvements to several other existing models have resulted in release of MELCOR 1.8.3. In addition, continuing efforts to expand the code assessment database have filled in many of the gaps in phenomenological coverage. Efforts are now under way to develop models for chemical interactions of fission products with structural surfaces and for reactions of iodine in the presence of water, and work is also in progress to improve models for the scrubbing of fission products by water pools, the chemical reactions of boron carbide with steam, and the coupling of flow blockages with the hydrodynamics. Several code assessment analyses are in progress, and more are planned

Progress report on fast breeder reactor development in Japan, October - December 1976

International Nuclear Information System (INIS)

1977-03-01

As for the fast breeder experimental reactor ''Joyo'', the remodeling works for the bearings of primary main circulation pump and the support bands of hanger support have finished. Preparatory arrangement was made for the second performance test, such as preheating the primary cooling system and filling sodium in it. Construction, installation and adjustment of test and inspection apparatuses required after the criticality experiment are in progress. The lining work for the temporary storage pool for solid wastes, the enlarging work for the operation control building, and construction of the brake equipment for cooler blower were over. As for the operation control, operation, inspection and maintenance of each system required for the modeling work are being carried out, and new parts to take the place of old ones were provided. The analysis of the core characteristics and the development of operation-monitoring codes are in progress. The coordination design work (4) for the fast breeder prototype reactor ''Monju'' has been started, and the preliminary design work (2) for the demonstration reactor is going on. Geological, meteorological and seismic researches carried out at the proposed construction site for ''Monju''. The researches and developments on reactor physics, structural components, instrumentation and control, sodium technology, fuel materials, safety and steam generators are in progress. (Kako, I.)

Serologic test systems development. Progress report, October 1, 1978-September 30, 1979

Energy Technology Data Exchange (ETDEWEB)

Seawright, G.L.; Sanders, W.M.; Hollstein, U.; Butler, J.E.; Mills, K.W.; Despommier, D.D.; Zimmerman, W.J.; Martinez, E.; Hindman, K.R.; Payne, R.J.

1980-12-01

Work has continued on the development and automation of enzyme immunoassays (EIA) for detecting diseases and toxic agents in food animals. Further evaluations were made of the Technicon Autoanalyzer II(AAII) for conducting totally automated EIAs. The problems investigated were machine carryover and assay variation. Modifications greatly reduced or eliminated carryover and produced acceptable levels of test variation. The EIA for swine trichinosis was significantly improved by the use of a new, partially purified antigen preparation. The result was improved detection of early seroconversions and reduced probability for false negatives and false positives. The amplified EIA was adapted as a diagnostic test for bovine brucellosis and studies were initiated for differentiating vaccinated and infected animals. Preliminary data indicate that the IgG/sub 1/ response may be diagnostic but further studies are necessary. Development of the EIA for detecting low molecular weight contaminants and residues in food products was also initiated. Compounds studied were the antibiotics chloramphenicol, tetracycline, and gentamicin; the mycotoxin, aflatoxin, and the shale oil toxin, 2-aminofluorene. Results indicate that chloramphenicol nonspecifically binds to antibody and interferes with antibody activity. Thus, the test is not yet satisfactory. Initial attempts to automate the gentamicin test were unsuccessful because of machine carryover but modifications of the AAII have produced encouraging preliminary data. Work is continuing on the development of EIAs for all of the compounds mentioned above. (ERB)

Development of indigenous irradiator - current progress and challenges

International Nuclear Information System (INIS)

Anwar A Rahman; Mohd Arif Hamzah; Muhd Nor Atan; Aznor Hassan; Fadil Ismail; Julia A Karim; Rosli Darmawan

2009-01-01

The development of indigenous irradiator is one of Prototype Development Center main project to support Nuclear Malaysia services. Three (3) projects have been identified and currently the status is in final stage of design. There are some issues and challenges encountered, which delayed the project progress. The paper will discuss the current progress of development and challenges faced in designing the irradiator. (Author)

Overview of software development at the parabolic dish test site

Science.gov (United States)

Miyazono, C. K.

1985-01-01

The development history of the data acquisition and data analysis software is discussed. The software development occurred between 1978 and 1984 in support of solar energy module testing at the Jet Propulsion Laboratory's Parabolic Dish Test Site, located within Edwards Test Station. The development went through incremental stages, starting with a simple single-user BASIC set of programs, and progressing to the relative complex multi-user FORTRAN system that was used until the termination of the project. Additional software in support of testing is discussed including software in support of a meteorological subsystem and the Test Bed Concentrator Control Console interface. Conclusions and recommendations for further development are discussed.

IFMIF High Flux Test Module-Recent progress in design and manufacturing

International Nuclear Information System (INIS)

Leichtle, D.; Arbeiter, F.; Dolensky, B.; Fischer, U.; Gordeev, S.; Heinzel, V.; Ihli, T.; Lang, K.-H.; Moeslang, A.; Simakov, S.P.; Slobodchuk, V.; Stratmanns, E.

2008-01-01

The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Within the High Flux Test Module (HFTM) a testing volume of 0.5 l filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. The contribution also includes (i) recommendations for the use of container, rig and capsule materials, and (ii) a description of the fabrication routes for the entire HFTM including brazing and filling procedures which are currently under development at the Forschungszentrum Karlsruhe

IFMIF High Flux Test Module-Recent progress in design and manufacturing

Energy Technology Data Exchange (ETDEWEB)

Leichtle, D. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)], E-mail: leichtle@irs.fzk.de; Arbeiter, F.; Dolensky, B.; Fischer, U.; Gordeev, S.; Heinzel, V.; Ihli, T.; Lang, K.-H. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany); Moeslang, A. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Materialforschung, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Simakov, S.P.; Slobodchuk, V.; Stratmanns, E. [Association FZK-EURATOM, Forschungszentrum Karlsruhe, Institut fuer Reaktorsicherheit, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen (Germany)

2008-12-15

The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Within the High Flux Test Module (HFTM) a testing volume of 0.5 l filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. The contribution also includes (i) recommendations for the use of container, rig and capsule materials, and (ii) a description of the fabrication routes for the entire HFTM including brazing and filling procedures which are currently under development at the Forschungszentrum Karlsruhe.

[Progress in isokinetic technology in testing and training for assessment of muscle function].

Science.gov (United States)

Huang, Ting-Ting; Fan, Li-Hua; Gao, Dong; Xia, Qing; Zhang, Min

2013-02-01

Isokinetic technology in testing and training is the most advanced practical technique in the evaluation of muscle function. This method is a continuous dynamic test in the full range of the joint motion which has strong pertinence at the aspect of assessing muscle strength, and is an objective and quantitative method for reflecting each point's muscle strength in the range of the joint motion. This article reviews the key concepts, brief history of development and influencing factors of isokinetic technology in testing and training, introduces the progress in the field of rehabilitation medicine and sport science, etc., and discusses the future exploration in forensic science.

Baseline gas turbine development program. Eighteenth quarterly progress report

Energy Technology Data Exchange (ETDEWEB)

Schmidt, F W; Wagner, C E [comps.

1977-04-30

Progress is reported for a program whose goals are to demonstrate an experimental upgraded gas turbine powered automobile which meets the 1978 Federal Emissions Standards, has significantly improved fuel economy, and is competitive in performance, reliability, and potential manufacturing cost with the conventional piston engine powered, compact-size American automobile. Initial running of the upgraded engine took place on July 13, 1976. The engine proved to be mechanically sound, but was also 43% deficient in power. A continuing corrective development effort has to date reduced the power deficiency to 32%. Compressor efficiency was increased 2 points by changing to a 28-channel diffuser and tandem deswirl vanes; improved processing of seals has reduced regenerator leakage from about 5 to 2.5% of engine flow; a new compressor turbine nozzle has increased compressor turbine stage efficiency by about 1 point; and adjustments to burner mixing ports has reduced pressure drop from 2.8 to 2.1% of engine pressure. Key compressor turbine component improvements are scheduled for test during the next quarterly period. During the quarter, progress was also made on development of the Upgraded Vehicle control system; and instrumentation of the fourth program engine was completed by NASA. The engine will be used for development efforts at NASA LeRC.

Sleep Problems are Associated with Development and Progression of Lower Urinary Tract Symptoms: Results from REDUCE.

Science.gov (United States)

Branche, Brandee L; Howard, Lauren E; Moreira, Daniel M; Roehrborn, Claus; Castro-Santamaria, Ramiro; Andriole, Gerald L; Hopp, Martin L; Freedland, Stephen J

2018-02-01

Although lower urinary tract symptoms and sleep problems often develop together, to our knowledge it is unknown whether sleep disturbances are linked to lower urinary tract symptoms development and progression. As measured by the 6-item MOS-Sleep (Medical Outcomes Study Sleep Scale) survey we examined the relationship between sleep problems, and the development and progression of lower urinary tract symptoms in the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) study. REDUCE was a randomized trial testing prostate cancer chemoprevention with dutasteride in men with prostate specific antigen 2.5 to 10 ng/ml and a negative biopsy. At baseline men completed MOS-Sleep and a scaled average was used to calculate the sleep score. Men were followed for 4 years and I-PSS (International Prostate Symptom Score) was completed at baseline and every 6 months. Asymptomatic men had I-PSS less than 8 while symptomatic men had I-PSS 8 or greater. In the placebo arm of 2,588 men not receiving α-blockers or 5α-reductase inhibitors at baseline we tested the association between sleep problems and lower urinary tract symptom development and progression using Cox models. During followup lower urinary tract symptoms developed in 209 of 1,452 asymptomatic men (14%) and 580 of 1,136 (51%) with lower urinary tract symptoms demonstrated progression. On multivariable analysis higher sleep scores were suggestively associated with increased lower urinary tract symptoms in asymptomatic men (quartile 4 vs 1 HR 1.41, 95% CI 0.92-2.17, p = 0.12) and with lower urinary tract symptom progression in symptomatic men (per 10 points of sleep score HR 1.06, 95% CI 1.01-1.12, p = 0.029). Among men with lower urinary tract symptoms worse sleep scores were associated with the progression of lower urinary tract symptoms and among asymptomatic men worse sleep scores were suggestively associated with the development of lower urinary tract symptoms. If confirmed, these data suggest that sleep

Test development and use in five Iberian Latin American countries.

Science.gov (United States)

Wechsler, Solange M; Oakland, Thomas; León, Carmem; Vivas, Eleonora; de Almeida, Leandro; Franco, Amanda; Pérez-Solís, María; Contini, Norma

2014-08-01

The abundance of scholarship on test development and use generally is higher in English-speaking than in Iberian Latin American countries. The purpose of this article is to help overcome this imbalance by describing and identifying similarities and differences in test development and use in two Iberian (Portugal and Spain) and three of the largest Latin American (Argentina, Brazil, and Venezuela) countries. The stages of test development in each country, roles of professional associations, presence of standards for test use, professionals' educational training, commonly used tests, together with prominent challenges to continued progress are discussed. Test development and use in these five countries are transitioning from a dependence on the use of translated tests to greater reliance on adapted and finally nationally constructed tests. Continued growth requires adherence to international standards guiding test development and use. Stronger alliance among professional associations in the Iberian Latin American countries could serve as a catalyst to promote test development in these regions. © 2014 International Union of Psychological Science.

Gammasphere software development. Progress report

Energy Technology Data Exchange (ETDEWEB)

Piercey, R.B.

1994-01-01

This report describes the activities of the nuclear physics group at Mississippi State University which were performed during 1993. Significant progress has been made in the focus areas: chairing the Gammasphere Software Working Group (SWG); assisting with the porting and enhancement of the ORNL UPAK histogramming software package; and developing standard formats for Gammasphere data products. In addition, they have established a new public ftp archive to distribute software and software development tools and information.

Progression and regression of cervical pap test lesions in an urban AIDS clinic in the combined antiretroviral therapy era: a longitudinal, retrospective study.

Science.gov (United States)

Lofgren, Sarah M; Tadros, Talaat; Herring-Bailey, Gina; Birdsong, George; Mosunjac, Marina; Flowers, Lisa; Nguyen, Minh Ly

2015-05-01

Our objective was to evaluate the progression and regression of cervical dysplasia in human immunodeficiency virus (HIV)-positive women during the late antiretroviral era. Risk factors as well as outcomes after treatment of cancerous or precancerous lesions were examined. This is a longitudinal retrospective review of cervical Pap tests performed on HIV-infected women with an intact cervix between 2004 and 2011. Subjects needed over two Pap tests for at least 2 years of follow-up. Progression was defined as those who developed a squamous intraepithelial lesion (SIL), atypical glandular cells (AGC), had low-grade SIL (LSIL) followed by atypical squamous cells-cannot exclude high-grade SIL (ASC-H) or high-grade SIL (HSIL), or cancer. Regression was defined as an initial SIL with two or more subsequent normal Pap tests. Persistence was defined as having an SIL without progression or regression. High-risk human papillomavirus (HPV) testing started in 2006 on atypical squamous cells of undetermined significance (ASCUS) Pap tests. AGC at enrollment were excluded from progression analysis. Of 1,445 screened, 383 patients had over two Pap tests for a 2-year period. Of those, 309 had an intact cervix. The median age was 40 years and CD4+ cell count was 277 cells/mL. Four had AGC at enrollment. A quarter had persistently normal Pap tests, 64 (31%) regressed, and 50 (24%) progressed. Four developed cancer. The only risk factor associated with progression was CD4 count. In those with treated lesions, 24 (59%) had negative Pap tests at the end of follow-up. More studies are needed to evaluate follow-up strategies of LSIL patients, potentially combined with HPV testing. Guidelines for HIV-seropositive women who are in care, have improved CD4, and have persistently negative Pap tests could likely lengthen the follow-up interval.

Second progress report on pre-test calculations for the large block test

International Nuclear Information System (INIS)

Lee, K.H.

1995-01-01

The US Department of Energy's (DOE) Yucca Mountain Site Characterization Project (YMP) is investigating the suitability of the Topopah Spring tuff in the thick vadose zone at Yucca Mountain, Nevada, as a host rock for permanent disposal of high-level radioactive waste. As part of the YMP, a group of field tests, called the Large Block Test (LBT), will be conducted on a large electrically heated block of Topopah Spring tuff. The block will be heated by electrical heaters. The goals of the LBT are to gain information on the coupled thermal-mechanical-hydrological-chemical processes that will be active in the near-field environment of a repository; to provide field data for testing and calibrating models; and to help in the development of measurement systems and techniques. In this second progress report, we present results of the final set of numerical modeling calculations performed in support of the LBT design. The results include block temperatures and heat fluxes across the surfaces. The results are applied primarily to the design of guard heaters to enforce adiabatic conditions along the block walls. Conduction-only runs are adequate to estimate the thermal behavior of the system, because earlier calculations showed that heat transfer in the block is expected to be dominated by conduction. In addition, conduction-only runs can be made at substantially shorter execution times than full hydrothermal runs. We also run a two-dimensional, hydrothermal, discrete fracture model, with 200-μm vertical fractures parallel to the heaters and occurring at a uniform spacing of 30 cm. The results show the development of distinct dryout and recondensation zones. The dryout zones are thickest at the fractures and thinnest in the matrix midway between the fractures

Progress on the Development of Future Airport Surface Wireless Communications Network

Science.gov (United States)

Kerczewski, Robert J.; Budinger, James M.; Brooks, David E.; Franklin, Morgan; DeHart, Steve; Dimond, Robert P.; Borden, Michael

2009-01-01

Continuing advances in airport surface management and improvements in airport surface safety are required to enable future growth in air traffic throughout the airspace, as airport arrival and departure delays create a major system bottleneck. These airport management and safety advances will be built upon improved communications, navigation, surveillance, and weather sensing, creating an information environment supporting system automation. The efficient movement of the digital data generated from these systems requires an underlying communications network infrastructure to connect data sources with the intended users with the required quality of service. Current airport surface communications consists primarily of buried copper or fiber cable. Safety related communications with mobile airport surface assets occurs over 25 kHz VHF voice and data channels. The available VHF spectrum, already congested in many areas, will be insufficient to support future data traffic requirements. Therefore, a broadband wireless airport surface communications network is considered a requirement for the future airport component of the air transportation system. Progress has been made on defining the technology and frequency spectrum for the airport surface wireless communications network. The development of a test and demonstration facility and the definition of required testing and standards development are now underway. This paper will review the progress and planned future work.

Projects at the component development and integration facility. Quarterly technical progress report, April 1, 1994--June 30, 1994

International Nuclear Information System (INIS)

1994-01-01

This quarterly technical progress report presents progress on the projects at the Component Development and Integration Facility (CDIF) during the third quarter of FY94. The CDIF is a major Department of Energy test facility in Butte, Montana, operated by MSE, Inc. Projects in progress include: Biomass Remediation Project; Heavy Metal-Contaminated Soil Project; MHD Shutdown; Mine Waste Technology Pilot Program; Plasma Projects; Resource Recovery Project; and Spray Casting Project

Progress Testing for Medical Students at the University of Auckland: Results from the First Year of Assessments

Directory of Open Access Journals (Sweden)

Steven Lillis

2014-01-01

Full Text Available Background Progress testing is a method of assessing longitudinal progress of students using a single best answer format pitched at the standard of a newly graduated doctor. Aim To evaluate the results of the first year of summative progress testing at the University of Auckland for Years 2 and 4 in 2013. SUBJECTS: Two cohorts of medical students from Years 2 and 4 of the Medical Program. Methods A survey was administered to all involved students. Open text feedback was also sought. Psychometric data were collected on test performance, and indices of reliability and validity were calculated. Results The three tests showed increased mean scores over time. Reliability of the assessments was uniformly high. There was good concurrent validity. Students believe that progress testing assists in integrating science with clinical knowledge and improve learning. Year 4 students reported improved knowledge retention and deeper understanding. Conclusion Progress testing has been successfully introduced into the Faculty for two separate year cohorts and results have met expectations. Other year cohorts will be added incrementally. Recommendation Key success factors for introducing progress testing are partnership with an experienced university, multiple and iterative briefings with staff and students as well as demonstrating the usefulness of progress testing by providing students with detailed feedback on performance.

Progress in the development of very high density research and test reactor fuels

Energy Technology Data Exchange (ETDEWEB)

Wachs, D.M. [Idaho National Laboratory, P.O. Box 2528, Idaho Falls, Idaho 83415 (United States)

2009-06-15

New nuclear fuels are being developed to enable many of the most important research and test reactors worldwide to convert from high enriched uranium (HEU) fuels to low enriched uranium (LEU) fuels without significant loss in performance. The last decade of work has focused on the development of uranium-molybdenum alloy (U-Mo) based fuels and is an international effort that includes the active participation of more than ten national programs. The US RERTR program, under the NNSA's Global Threat Reduction Initiative (GTRI), is in the process of developing both dispersion and monolithic U-Mo fuel designs. While the U-Mo fuel alloy has behaved extremely well under irradiation, initial testing (circa 2003) revealed that the U-Mo fuels dispersed in aluminum had an unexpected tendency toward unstable swelling (pillowing) under high-power conditions. Technical investigations were initiated worldwide at this time by the partner programs to understand this behavior as well as to develop and test remedies. The behavior was corrected by modifying the chemistry of the U-Mo/Al interfaces in both fuel designs. In the dispersion fuel design, this was accomplished by the addition of small amounts of silicon to the aluminum matrix material. Two methods are under development for the monolithic fuel design, which include the application of a thin layer of silicon or a thin zirconium based diffusion barrier at the fuel/clad interface. This paper gives an overview of the current status of U-Mo fuel development, including basic research results, manufacturing aspects, results of the latest irradiations and post irradiation examinations, the approach to fuel performance qualification, and the scale-up and commercialization of fabrication technology. (authors)

The RERTR [Reduced Enrichment Research and Test Reactor] Program: Progress and plans

International Nuclear Information System (INIS)

Travelli, A.

1987-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1986, the activities, results, and new developments which occurred in 1987 are reviewed. Irradiation of the second miniplate series, concentrating on U 3 Si 2 -Al and U 3 Si-Al fuels, was completed and postirradiation examinations were performed on many of its miniplates. The whole-core ORR demonstration with U 3 Si 2 -Al fuel at 4.8 g U/cm 3 was completed at the end of March with excellent results and with 29 elements estimated to have reached at least 40% average burnup. Good progress was made in the area of LEU usage for the production of fission 99 Mo, and in the coordination of safety evaluations related to LEU conversions of US university reactors. Planned activities include testing and demonstrating advanced fuels intended to allow use of reduced enrichment uranium in very-high-performance reactors. Two candidate fuels are U 3 Si-Al with 19.75% enrichment and U 3 Si 2 -Al with 45% enrichment. Demonstration of these fuels will include irradiation of full-size elements and, possibly, a full-core demonstration. Achievement of the final program goals is still projected for 1990. This progress could not have been possible without the close international cooperation which has existed from the beginning, and which is essential to the ultimate success of the RERTR Program

Progress in the development of superconducting quadrupoles for heavy ion fusion

International Nuclear Information System (INIS)

Faltens, A.; Lietzke, A.; Sabbi, G.; Seidl, P.; Lund, S.; Manahan, B.; Martovetsky, N.; Gung, C.; Minervini, J.; Schultz, J.; Myatt, L.; Meinke, R.

2002-01-01

The Heavy Ion Fusion program is developing single aperture superconducting quadrupoles based on NbTi conductor, for use in the High Current Experiment at Lawrence Berkeley National Laboratory. Following the fabrication and testing of prototypes using two different approaches, a baseline design has been selected and further optimized. A prototype cryostat for a quadrupole doublet, with features to accommodate induction acceleration modules, is being fabricated. The single aperture magnet was derived from a conceptual design of a quadrupole array magnet for multi-beam transport. Progress on the development of superconducting quadrupole arrays for future experiments is also reported

Progress in the development of superconducting quadrupoles for heavy ion fusion

Energy Technology Data Exchange (ETDEWEB)

Faltens, A.; Lietzke, A.; Sabbi, G.; Seidl, P.; Lund, S.; Manahan, B.; Martovetsky, N.; Gung, C.; Minervini, J.; Schultz, J.; Myatt, L.; Meinke, R.

2002-05-24

The Heavy Ion Fusion program is developing single aperture superconducting quadrupoles based on NbTi conductor, for use in the High Current Experiment at Lawrence Berkeley National Laboratory. Following the fabrication and testing of prototypes using two different approaches, a baseline design has been selected and further optimized. A prototype cryostat for a quadrupole doublet, with features to accommodate induction acceleration modules, is being fabricated. The single aperture magnet was derived from a conceptual design of a quadrupole array magnet for multi-beam transport. Progress on the development of superconducting quadrupole arrays for future experiments is also reported.

Progress in the Development of Superconducting Quadrupoles forHeavy-ion Fusion

Energy Technology Data Exchange (ETDEWEB)

Faltens, A.; Lietzke, A.; Sabbi, G.; Seidl, P.; Lund, S.; Manahan, R.; Martovetsky, N.; Gung, C.; Minervini, J.; Schultz, J.; Myatt, L.; Meinke, R.

2002-08-19

The Heavy Ion Fusion program is developing single aperture superconducting quadrupoles based on NbTi conductor, for use in the High Current Experiment at Lawrence Berkeley National Laboratory. Following the fabrication and testing of prototypes using two different approaches, a baseline design has been selected and further optimized. A prototype cryostat for a quadrupole doublet, with features to accommodate induction acceleration modules, is being fabricated. The single aperture magnet was derived from a conceptual design of a quadrupole array magnet for multi-beam transport. Progress on the development of superconducting quadrupole arrays for future experiments is also reported.

Progression of Carpal Tunnel Syndrome According to Electrodiagnostic Testing in Nonoperatively Treated Patients

Directory of Open Access Journals (Sweden)

Mark van Suchtelen

2014-09-01

Full Text Available Background:  This study tested the null hypothesis that nonoperatively treated patients would not show disease progression of carpal tunnel syndrome (CTS over time according to median nerve distal motor latency (DML on two electrodiagnostic tests.   Methods:  This retrospective study analyzed sixty-two adult nonoperatively treated patients who were diagnosed with CTS confirmed by a minimum of two electrodiagnostic tests at our institution between December 2006 and  tober 2012. A Wilcoxon signed-rank test was conducted to test the difference between electrodiagnostic measurements between the first and last test. Results: The mean time between the first and last electrodiagnostic test was 26±12 months (range, 12 to 55 months. The only electrodiagnostic measurement that increased significantly was the difference between median and ulnar DML on the same side (r=0.19, P =0.038. The time between the electrodiagnostic tests was significantly longer for patients with at least 10% worsening of the DML at the second test compared to cases of which the DML did not worsen or improve a minimum of 10% (P =0.015.  Conclusions: There is evidence that—on average—idiopathic median neuropathy at the carpal tunnel slowly progresses over time, and this can be measured with electrodiagnostics, but studies with a much longer interval between lectrodiagnostic tests may be needed to determine if it always progresses.

Applied nuclear data research and development. Semiannual progress report, April 1-September 30, 1983

International Nuclear Information System (INIS)

Arthur, E.D.

1984-06-01

This progress report describes the activities of the Los Alamos Nuclear Data Group for April 1, 1983 through September 30, 1983. Topics covered include theory and evaluation of nuclear cross sections; nuclear cross-section processing and testing; neutron activation; fission products, and actinides; and core neutronics code development in support of LMFBR carbide core assessment

Applied nuclear data research and development. Semiannual progress report, April 1-September 30, 1983

Energy Technology Data Exchange (ETDEWEB)

Arthur, E.D. (comp.)

1984-06-01

This progress report describes the activities of the Los Alamos Nuclear Data Group for April 1, 1983 through September 30, 1983. Topics covered include theory and evaluation of nuclear cross sections; nuclear cross-section processing and testing; neutron activation; fission products, and actinides; and core neutronics code development in support of LMFBR carbide core assessment. (GHT)

Yucca Mountain drift scale test progress report

Energy Technology Data Exchange (ETDEWEB)

Apps, J.; Birkholzer, J.T.; Peterson,J.E.; Sonnenthal, E.; Spycher, N.; Tsang, Y.W.; Williams, K.H.

1999-01-01

The Drift Scale Test (DST) is part of the Exploratory Studies Facility (ESF) Thermal Test being conducted underground at the potential high-level nuclear waste repository at Yucca Mountain, Nevada. The purpose of the ESF Thermal Test is to acquire a more in-depth understanding of the coupled thermal, mechanical, hydrological, and chemical processes likely to be encountered in the rock mass surrounding the potential geological repository at Yucca Mountain. These processes are monitored by a multitude of sensors to measure the temperature, humidity, gas pressure, and mechanical displacement, of the rock formation in response to the heat generated by the heaters. In addition to collecting passive monitoring data, active hydrological and geophysical testing is also being carried out periodically in the DST. These active tests are intended to monitor changes in the moisture redistribution in the rock mass, to collect water and gas samples for chemical and isotopic analysis, and to detect microfiacturing due to heating. On December 3, 1998, the heaters in the DST were activated. The planned heating phase of the DST is 4 years, and the cooling phase following the power shutoff will be of similar duration. The present report summarizes interpretation and analysis of thermal, hydrological, chemical, and geophysical data for the first 6 months; it is the first of many progress reports to be prepared during the DST.

Research progress in roles of gut microbiota and bile acid metabolism in development and progression of NAFLD

Directory of Open Access Journals (Sweden)

LU Xu

2014-11-01

Full Text Available With the prevalence of obesity and metabolic syndrome, the incidence of nonalcoholic fatty liver disease (NAFLD is increasing year by year. Studies have uncovered the important roles of gut microbiota and bile acid metabolism in the development and progression of NAFLD. The roles of gut microbiota, as well bile acid and bile acid receptors, in the development and progression of NAFLD are highlighted.

Small scale tests on the progressive retreat of soil slopes

Science.gov (United States)

Voulgari, Chrysoula; Utili, Stefano; Castellanza, Riccardo

2015-04-01

In this paper, the influence due to the presence of cracks on the morphologic evolution of natural cliffs subject to progressive retreat induced by weathering is investigated through small scale laboratory tests. Weathering turns hard rocks into soft rocks that maintain the structure of the intact rocks, but are characterised by higher void ratios and reduced bond strengths; soft rocks are transformed into granular soils generally called residual soils. A number of landslides develop in slopes due to weathering which results in the progressive retrogression of the slope face and the further degradation within the weathering zone. Cracks, that are widely present, can be a result of weathering and they can cause a significant decrease in their stability, as they provide preferential flow channels which increase the soil permeability and decrease the soil strength. The geological models employed until now are mainly empirical. Several researchers have tried to study the stability of slopes through experimental procedures. Centrifuge modelling is widely used to investigate the failure of slopes. Small scale tests are also an important approach, in order to study the behaviour of a slope under certain conditions, such as the existence of water, as they allow the observation of the infiltration processes, the movement of the weathering front, deformation and failure. However, the deformation response of a slope subject to weathering is not yet thoroughly clarified. In this work, a set of experiments were conducted to investigate weathering induced successive landslides. Weathering was applied to the slope model by wetting the slope crest through a rainfall simulator device. The moisture content of the soil during the tests was monitored by soil moisture sensors that were buried inside the slope model. High resolution cameras were recording the behaviour of the slope model. GeoPIV was used to analyse the frames and obtain the deformations of the slope model during the

Proinflammatory Cytokines in Prostate Cancer Development and Progression Promoted by High-Fat Diet

Directory of Open Access Journals (Sweden)

Hua Xu

2015-01-01

Full Text Available Background. We aimed to examine whether proinflammatory cytokines participated in prostate cancer (PCa development and progression promoted by high-fat diet (HFD. Methods. TRAMP (transgenic adenocarcinoma mouse prostate mice were randomly divided into two groups: normal diet group and HFD group. Mortality rate and tumor formation rate were examined. TRAMP mice were sacrificed and sampled on the 20th, 24th, and 28th week, respectively. Levels of proinflammatory cytokines, including IL-1α, IL-1β, IL-6, and TNF-α, were tested by FlowCytomix. Prostate tissue of TRAMP mice was used for histology study. Results. A total of 13 deaths of TRAMP mice were observed, among which 3 (8.33% were from the normal diet group and 10 (27.78% from the HFD group. The mortality rate of TRAMP mice from HFD group was significantly higher than that of normal diet group (P=0.032. Tumor formation rate at 20th week of age of HFD group was significantly higher than that of normal diet group (P=0.045. Proinflammatory cytokines levels, including IL-1α, IL-1β, IL-6, and TNF-α, were significantly higher in HFD TRAMP mice. Conclusions. HFD could promote TRAMP mouse PCa development and progression with elevated proinflammatory cytokines levels. Proinflammatory cytokines could contribute to PCa development and progression promoted by HFD.

Recent progress in shear punch testing

International Nuclear Information System (INIS)

Hamilton, M.L.; Toloczko, M.B.; Lucas, G.E.

1994-09-01

The shear punch test was developed in response to the needs of the materials development community for small-scale mechanical properties tests. Such tests will be of great importance when a fusion neutron simulation device is built, since such a device is expected to have a limited irradiation volume. The shear punch test blanks a circular disk from a fixed sheet metal specimen, specifically a TEM disk. Load-displacement data generated during the test can be related to uniaxial tensile properties such as yield and ultimate strength. Shear punch and tensile tests were performed at room temperature on a number of unirradiated aluminum, copper, vanadium, and stainless steel alloys and on several irradiated aluminum alloys. Recent results discussed here suggest that the relationship between shear punch strength and tensile strength varies with alloy class, although the relationship determined for the unirradiated condition remains valid for the irradiated aluminum alloys

Recent progress and tests of radiation resistant impregnation materials for Nb3Sn coils

International Nuclear Information System (INIS)

Bossert, R.; Krave, S.; Ambrosio, G.; Andreev, N.; Chlachidze, G.; Nobrega, A.; Novitski, I.; Yu, M.; Zlobin, A. V.

2014-01-01

Fermilab is collaborating with Lawrence Berkeley National Laboratory (LBNL) and Brookhaven National Laboratory (BNL) (US-LARP collaboration) to develop a large-aperture Nb 3 Sn superconducting quadrupole for the Large Hadron Collider (LHC) luminosity upgrade. An important component of this work is the development of materials that are sufficiently radiation resistant for use in critical areas of the upgrade. This paper describes recent progress in characterization of materials, including the baseline CTD101K epoxy, cyanate ester blends, and Matrimid 5292, a bismaleimide-based system. Structural properties of “ten stacks” of cable impregnated with these materials are tested at room and cryogenic temperatures and compared to the baseline CT-101K. Experience with potting 1 and 2 meter long coils with Matrimid 5292 are described. Test results of a single 1-m coil impregnated with Matrimid 5292 are reported and compared to similar coils impregnated with the traditional epoxy

Recent progress and tests of radiation resistant impregnation materials for Nb3Sn coils

Science.gov (United States)

Bossert, R.; Krave, S.; Ambrosio, G.; Andreev, N.; Chlachidze, G.; Nobrega, A.; Novitski, I.; Yu, M.; Zlobin, A. V.

2014-01-01

Fermilab is collaborating with Lawrence Berkeley National Laboratory (LBNL) and Brookhaven National Laboratory (BNL) (US-LARP collaboration) to develop a large-aperture Nb3Sn superconducting quadrupole for the Large Hadron Collider (LHC) luminosity upgrade. An important component of this work is the development of materials that are sufficiently radiation resistant for use in critical areas of the upgrade. This paper describes recent progress in characterization of materials, including the baseline CTD101K epoxy, cyanate ester blends, and Matrimid 5292, a bismaleimide-based system. Structural properties of "ten stacks" of cable impregnated with these materials are tested at room and cryogenic temperatures and compared to the baseline CT-101K. Experience with potting 1 and 2 meter long coils with Matrimid 5292 are described. Test results of a single 1-m coil impregnated with Matrimid 5292 are reported and compared to similar coils impregnated with the traditional epoxy.

Preliminary Design Progress of the HCCR TBM for ITER testing

Energy Technology Data Exchange (ETDEWEB)

Lee, Dong Won; Park, Sung Dae; Kim, Dong Jun; Jin, Hyung Gon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Ahn, Mu-Young [National Fusion Research Institute, Daejeon (Korea, Republic of)

2016-10-15

Korea has designed a helium cooled ceramic reflector (HCCR) test blanket module (TBM) including the TBM-shield, which is called the TBM-set, to be tested in ITER, a Nuclear Facility INB-174. Through the conceptual design review (CDR), its design integrity was successfully demonstrated at the conceptual design level at various loads. After CD approval, preliminary design (PD) was started and the progress is introduced in the present study. After PD review and approval, final design and then fabrication will be started. The main purpose of PD is to design the TBM-set according to the fabrication aspect and more detailed design for interfaces with ITER machine, such as installed TBM port plug and frame. With these considering, PD of TBM-set was started. PD for HCCR TBM has been performed (so far v0.24) from the CD model. FW, BZ, SW, TES/NAS, BM, and connecting support design were performed through the analyses, if necessary. The manufacturability was the main concern for PD model development. Thermal hydraulic analysis will be performed to evaluate the temperature and pressure drop in TBM-set. The structural integrity of TBM-set will be confirmed with combined various loads condition.

Progress in the development of the write process

Energy Technology Data Exchange (ETDEWEB)

Guffey, F.D.; Fahy, J.; Worman, D.; Lowry, C.; Mones, C. [Western Research Inst., Laramie, WY (United States); Corscadden, T.; Diduch, G. [MEG Energy Corp., Calgary, AB (Canada)

2009-07-01

This presentation described the commercialization of a field deployable upgrader developed by the Western Research Institute (WRI). The WRI Thermal Enhancement (WRITE) process was first tested in a 1-bbl/day bench scale unit. Based on the results of the testing program, a 5 bbl/day WRITE Process pilot plant was designed and built. It is currently in operation at WRI's Advanced Technology Center in Laramie, Wyoming. The 5 bbl/day WRITE Process pilot plant includes a 5 bbl/day distillate recovery unit (DRU) and a continuous coker that receives the produced bottoms. The DRU recovers diluent for recycling. The bitumen undergoes thermal conversion in the WRITE reactor to produce a pipeline quality product. The pyrolyzate produced by the coker is blended with the DRU to produce a synthetic crude oil (SCO) that is pipelined to existing refineries. Studies are currently underway at the pilot plant using dilbit produced at EMG's Christina Lake site. This presentation described the experimental program that is in progress. It also discussed the commercial viability of the technology for producing a pipeline quality product. tabs., figs.

Progression of carpal tunnel syndrome according to electrodiagnostic testing in nonoperatively treated patients

NARCIS (Netherlands)

van Suchtelen, Mark; Becker, Stéphanie J. E.; Gruber, Jillian S.; Ring, David

2014-01-01

This study tested the null hypothesis that nonoperatively treated patients would not show disease progression of carpal tunnel syndrome (CTS) over time according to median nerve distal motor latency (DML) on two electrodiagnostic tests. This retrospective study analyzed sixty-two adult

Design and development of progressive tool for manufacturing washer

Science.gov (United States)

Annigeri, Ulhas K.; Raghavendra Ravi Kiran, K.; Deepthi, Y. P.

2017-07-01

In a progressive tool the raw material is worked at different station to finally fabricate the component. A progressive tool is a lucrative tool for mass production of components. A lot of automobile and other transport industries develop progressive tool for the production of components. The design of tool involves lot of planning and the same amount of skill of process planning is required in the fabrication of the tool. The design also involves use of thumb rules and standard elements as per experience gained in practice. Manufacturing the press tool is a laborious task as special jigs and fixtures have to be designed for the purpose. Assembly of all the press tool elements is another task where use of accurate measuring instruments for alignment of various tool elements is important. In the present study, design and fabrication of progressive press tool for production of washer has been developed and the press tool has been tried out on a mechanical type of press. The components produced are to dimensions.

Recent Progress in the Development of Diagnostic Tests for Malaria.

Science.gov (United States)

Krampa, Francis D; Aniweh, Yaw; Awandare, Gordon A; Kanyong, Prosper

2017-09-19

The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories lack standard facilities, expertise or diagnostic supplies; thus, therapy is administered based on clinical or self-diagnosis. There is the need for accurate diagnosis of malaria due to the continuous increase in the cost of medication, and the emergence and spread of drug resistant strains. However, the widely utilized Giemsa-stained microscopy and immunochromatographic tests for malaria are liable to several drawbacks, including inadequate sensitivity and false-positive outcomes. Alternative methods that offer improvements in performance are either expensive, have longer turnaround time or require a level of expertise that makes them unsuitable for point-of-care (POC) applications. These gaps necessitate exploration of more efficient detection techniques with the potential of POC applications, especially in resource-limited settings. This minireview discusses some of the recent trends and new approaches that are seeking to improve the clinical diagnosis of malaria.

Recent Progress in the Development of Diagnostic Tests for Malaria

Directory of Open Access Journals (Sweden)

Francis D. Krampa

2017-09-01

Full Text Available The impact of malaria on global health has continually prompted the need to develop effective diagnostic strategies. In malaria endemic regions, routine diagnosis is hampered by technical and infrastructural challenges to laboratories. These laboratories lack standard facilities, expertise or diagnostic supplies; thus, therapy is administered based on clinical or self-diagnosis. There is the need for accurate diagnosis of malaria due to the continuous increase in the cost of medication, and the emergence and spread of drug resistant strains. However, the widely utilized Giemsa-stained microscopy and immunochromatographic tests for malaria are liable to several drawbacks, including inadequate sensitivity and false-positive outcomes. Alternative methods that offer improvements in performance are either expensive, have longer turnaround time or require a level of expertise that makes them unsuitable for point-of-care (POC applications. These gaps necessitate exploration of more efficient detection techniques with the potential of POC applications, especially in resource-limited settings. This minireview discusses some of the recent trends and new approaches that are seeking to improve the clinical diagnosis of malaria.

Keratoconus Progression in Patients With Allergy and Elevated Surface Matrix Metalloproteinase 9 Point-of-Care Test.

Science.gov (United States)

Mazzotta, Cosimo; Traversi, Claudio; Mellace, Pierfrancesco; Bagaglia, Simone A; Zuccarini, Silvio; Mencucci, Rita; Jacob, Soosan

2017-10-04

To assess keratoconus (KC) progression in patients with allergies who also tested positive to surface matrix metalloproteinase 9 (MMP-9) point-of-care test. Prospective comparative study including 100 stage I-II keratoconic patients, mean age 16.7±4.6 years. All patients underwent an anamnestic questionnaire for concomitant allergic diseases and were screened with the MMP-9 point-of-care test. Patients were divided into two groups: patients KC with allergies (KC AL) and patients KC without allergies (KC NAL). Severity of allergy was established by papillary subtarsal response grade and KC progression assessed by Scheimpflug corneal tomography, corrected distance visual acuity (CDVA) measurement in a 12-month follow-up. The KC AL group included 52 patients and the KC NAL group 48. In the KC AL group, 42/52 of patients (81%) were positive to MMP-9 point-of-care test versus two positive patients in the KC NAL group (4%). The KC AL group data showed a statistically significant decrease of average CDVA, from 0.155±0.11 to 0.301±0.2 logarithm of the minimum angle of resolution (Paverage. The KC NAL group revealed a slight KC progression without statistically significant changes. Pearson correlation test showed a high correlation between Kmax worsening and severity of PSR in the KC AL group. The study demonstrated a statistically significant progression of KC in patients with concomitant allergies, positive to MMP-9 point-of-care test versus negative. A high correlation between severity of allergy and KC progression was documented.

Design and development of a continuously variable ratio transmission for an automotive vehicle, Phase IV. Quarterly progress report, December 1977--February 1978

Energy Technology Data Exchange (ETDEWEB)

None

1979-02-28

Progress in developing and testing a continuously variable ratio hydraulic transmission unit for automobiles is reported. Major emphasis was placed on the development of a co-axial hydrostatic module.

US Progress on Property Characterization to Support LEU U-10 Mo Monolithic Fuel Development

Energy Technology Data Exchange (ETDEWEB)

Cole, James Irvin [Idaho National Laboratory; Rabin, Barry H [Idaho National Laboratory; Smith, James Arthur [Idaho National Laboratory; Scott, Clark Landon [Idaho National Laboratory; Benefiel, Bradley Curtis [Idaho National Laboratory; Larsen, Eric David [Idaho National Laboratory; Lind, Robert Paul [Idaho National Laboratory; Sell, David Alan [Idaho National Laboratory

2016-03-01

The US High Performance Research Reactor program is pursuing development and qualification of a new high density monolithic LEU fuel to facilitate conversion of five higher power research reactors located in the US (ATR, HFIR, NBSR, MIT and MURR). In order to support fabrication development and fuel performance evaluations, new testing capabilities are being developed to evaluate the properties of fuel specimens. Residual stress and fuel-cladding bond strength are two characteristics related to fuel performance that are being investigated. In this overview, new measurement capabilities being developed to assess these characteristics in both fresh and irradiated fuel are described. Progress on fresh fuel testing is summarized and on-going hot-cell implementation efforts to support future PIE campaigns are detailed. It is anticipated that benchmarking of as-fabricated fuel characteristics will be critical to establishing technical bases for specifications that optimize fuel fabrication and ensure acceptable in-reactor fuel performance.

Progress and controversies in developing cancer vaccines

Directory of Open Access Journals (Sweden)

Speiser Daniel E

2005-04-01

Full Text Available Abstract Immunotherapy has become a standard approach for cancer management, through the use of cytokines (eg: interleukin-2 and monoclonal antibodies. Cancer vaccines hold promise as another form of immunotherapy, and there has been substantial progress in identifying shared antigens recognized by T cells, in developing vaccine approaches that induce antigen-specific T cell responses in cancer patients, and in developing new technology for monitoring immune responses in various human tissue compartments. Dramatic clinical regressions of human solid tumors have occurred with some cancer vaccines, but the rate of those responses remains low. This article is part of a 2-part point:counterpoint series on peptide vaccines and adoptive therapy approaches for cancer. The current status of cancer vaccination, and associated challenges, are discussed. Emphasis is placed on the need to increase our knowledge of cancer immunobiology, as well as to improve monitoring of cellular immune function after vaccination. Progress in both areas will facilitate development of effective cancer vaccines, as well as of adoptive therapy. Effective cancer vaccines promise to be useful for treatment and prevention of cancer at low cost and with low morbidity.

Progress in Development of the ITER Plasma Control System Simulation Platform

Science.gov (United States)

Walker, Michael; Humphreys, David; Sammuli, Brian; Ambrosino, Giuseppe; de Tommasi, Gianmaria; Mattei, Massimiliano; Raupp, Gerhard; Treutterer, Wolfgang; Winter, Axel

2017-10-01

We report on progress made and expected uses of the Plasma Control System Simulation Platform (PCSSP), the primary test environment for development of the ITER Plasma Control System (PCS). PCSSP will be used for verification and validation of the ITER PCS Final Design for First Plasma, to be completed in 2020. We discuss the objectives of PCSSP, its overall structure, selected features, application to existing devices, and expected evolution over the lifetime of the ITER PCS. We describe an archiving solution for simulation results, methods for incorporating physics models of the plasma and physical plant (tokamak, actuator, and diagnostic systems) into PCSSP, and defining characteristics of models suitable for a plasma control development environment such as PCSSP. Applications of PCSSP simulation models including resistive plasma equilibrium evolution are demonstrated. PCSSP development supported by ITER Organization under ITER/CTS/6000000037. Resistive evolution code developed under General Atomics' Internal funding. The views and opinions expressed herein do not necessarily reflect those of the ITER Organization.

The Transrapid test facility between system development and system application

Energy Technology Data Exchange (ETDEWEB)

Baur, L [MVP GmbH, Muenchen (Germany)

1996-12-31

In the development of a new rail technology, such as the magnetic levitation, there is - in contrast to the further development of the railway technology - not the possibility to use existing routes for the technical verification of the system technology until the application. Instead of this there are two possibilities: Cost-effective preliminary development on test beds and small test facilities up to a development stage which justifies the (relatively serious) risk of realising a service route early and to conclude the system trials and verification there; cost-intensive construction of a large-scale test facility which permits an application-related verification of all important system functions and thus creates the technical pre-requisites for a low-risk system application; The presentation deals with the technical requirements of the system at the test facility the challenges and chances linked to its realisation and adjustment to the rapidly progressing state-of-the-art and which this way opens up for a minimisation of the technical application risk. (orig./HW)

Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset

NARCIS (Netherlands)

M.K. Chan (Man K.); M.-O. Krebs (M-O); D. Cox; P.C. Guest (Paul); R.H. Yolken; H. Rahmoune (Hassan); M. Rothermundt (Matthias); J. Steiner (Johann); F.M. Leweke (Marcus); N.J.M. van Beveren (Nico); D. Niebuhr (David); N. Weber (Natalya); D. Cowan (David); P. Suarez-Pinilla; B. Crespo-Facorro (Benedicto); C. Mam-Lam-Fook; J. Bourgin; R.J. Wenstrup (Richard); R.R. Kaldate; J.D. Cooper (Jason); S. Bahn (Sabine)

2015-01-01

markdownabstractRecent research efforts have progressively shifted towards preventative psychiatry and prognostic identification of individuals before disease onset. We describe the development of a serum biomarker test for the identification of individuals at risk of developing schizophrenia based

Progress Report on Sodium Cooled Fast Breeder Reactor Development in Japan, April 1975

International Nuclear Information System (INIS)

Tomabechi, K.

1975-01-01

The progress of the sodium cooled fast Breeder Reactor development in Japan in the past 12 months can be summarized as follows. Installation of all the components of the Experimental Fast Reactor, ''JOYO'', was completed in the end of the last year and various commissioning tests of the reactor began in January 1975. It is planned to charge sodium into the reactor in coming fall and the first criticality experiment is currently planned in the summer 1976. Most of the research and development works for ''JOYO'' are nearing completion. These include an endurance test of 3 prototype primary sodium pump for 12,000 hours. 86 core fuel subassemblies and 220 blanket subassemblies, a sufficient number for composing the initial core, have already been fabricated. Concerning the Prototype Fast Breeder Reactor, ''MONJU'', design activity as well as relevant research and development works are continued. A siting problem exists and it is hoped to be resolved soon. Of the research and development works, a significant achievement in the past 12 months can be a successful operation at full power of the 50 MW Steam Generator Test Facility. This facility was put into operation at full power in June 1974. No leak of water into sodium has been experienced with operation of the steam generator tested. The steam generator is being dismantled for a detailed inspection originally planned

Experience of manual periodic testing and development of automatic test devices

International Nuclear Information System (INIS)

Lorenzen, J.; Bergdahl, B.G.; Oguma, R.; Pazsit, I.; Akerhielm, F.

1989-01-01

During more than two decades experience has been gained in the field of process control and instrumentation using signal noise analysis applied to measurements at Swedish nuclear power plants. The methods developed and employed cover areas like: - Sensor and component status test in safety systems during operation, - Monitoring of BWR-stability during start-up, - Thermal time constant analysis on irradiated fuel, - Monitoring of instrument tube vibrations during operation, Self-diagnosing neutron detectors. Together with stationary surveillance systems like SOLNAS for Early Warning based on spectral analysis and Pattern Recognition we use a mobile mini-computer twin station and PC/AT sets. Further theory development goes hand in hand with experimental results obtained through measurement campaigns. In the following some of the work under progress, demonstrated or already applied is described and the results are reported correspondingly

Progress toward the development and testing of source reconstruction methods for NIF neutron imaging.

Science.gov (United States)

Loomis, E N; Grim, G P; Wilde, C; Wilson, D C; Morgan, G; Wilke, M; Tregillis, I; Merrill, F; Clark, D; Finch, J; Fittinghoff, D; Bower, D

2010-10-01

Development of analysis techniques for neutron imaging at the National Ignition Facility is an important and difficult task for the detailed understanding of high-neutron yield inertial confinement fusion implosions. Once developed, these methods must provide accurate images of the hot and cold fuels so that information about the implosion, such as symmetry and areal density, can be extracted. One method under development involves the numerical inversion of the pinhole image using knowledge of neutron transport through the pinhole aperture from Monte Carlo simulations. In this article we present results of source reconstructions based on simulated images that test the methods effectiveness with regard to pinhole misalignment.

Exploring the Climate Literacy Development Utilizing a Learning Progressions Approach

Science.gov (United States)

Drewes, A.; Breslyn, W.; McGinnis, J. R.; Hestness, E.; Mouza, C.

2017-12-01

Climate change encompasses a broad and complex set of concepts that is often challenging for students and educators. Using a learning progressions framework, in this exploratory study we report our efforts to identify, describe, and organize the development of learners' understanding of climate change in an empirically supported learning progression (LP). The learning progression framework is a well suited analytical tool for investigating how student thinking develops over time (Duschl et al., 2007). Our primary research question is "How do learners progress over time from an initial to a more sophisticated understanding of climate change?"We followed a development process that involved drafting a hypothetical learning progression based on the science education research literature, consensus documents such as the Next Generation Science Standards and the Atlas of Science Literacy. Additionally, we conducted expert reviews with both climate scientists and educational researchers on the content and pedagogical expectations. Data are then collected from learners, which are used to modify the hypothetical learning progression based on how well it describes actual student learning. In this current analysis, we present findings from written assessments (N=294) and in-depth interviews (n=27) with middle school students in which we examine their understanding of the role of human activity, the greenhouse effect as the mechanism of climate change, local and global impacts, and strategies for the adaptation and mitigation of climate change. The culmination of our research is a proposed, empirically supported LP for climate change. Our LP is framed by consideration of four primary constructs: Human Activity, Mechanism, Impacts, and Mitigation and Adaptation. The conditional LP provides a solid foundation for continued research as well as providing urgently needed guidance to the education community on climate change education (for curriculum, instruction, and assessment

Factors of progress in reading literacy test

Directory of Open Access Journals (Sweden)

Jovanović Vitomir

2011-01-01

Full Text Available The main goal of this study was to identify the factors which are most associated with the progress in reading literacy assessed in the PISA survey. In the preliminary sample, students from ten schools (N=235 were retested two years after the 2009 PISA original study. There were measured intrinsic and extrinsic motivation, school self-efficacy, epistemological beliefs, metacognitive strategies, socio-economic status, enjoyment and preference for reading and motivation and self-regulation. The examined factors explain 27% of the variance in reading literacy progress. Factors that contribute most to this progress are school self-efficacy, proper use of metacognitive strategies and low extrinsic motivation. Socio-economic status explained a negligible amount of variance, while some effect of type of school on progress in reading literacy (η2=7% was observed. Achievement in reading literacy is correlated with school marks. Students who attend secondary schools are more likely to make progress in reading literacy than those who attend vocational schools. An attempt was made to formulate the implications for education policy based on this research.

Progress in the development of a tracking transition radiation detector

International Nuclear Information System (INIS)

Whitaker, J.S.; Beatty, J.; Shank, J.T.; Wilson, R.J.; Polychronakos, V.A.; Radeka, V.; Stephani, D.; Beker, H.; Bock, R.K.; Botlo, M.; Fabjan, C.W.; Pfennig, J.; Price, M.J.; Willis, W.J.; Akesson, T.; Chernyatin, V.; Dolgoshein, B.; Nevsky, P.; Potekhin, M.; Romanjuk, A.; Sosnovtsev, V.; Gavrilenko, I.; Maiburov, S.; Muravjev, S.; Shmeleva, A.

1990-01-01

The purpose of the TRD/Tracker is to provide charged particle tracking in the r-z plane and to provide particle identification capabilities that are independent of and complementary to calorimetric methods. The tracking goals include observation of the charged particle multiplicity and topology, reconstruction of the primary vertex or vertices, and assignment of charged particles to the correct vertex. Particle identification goals include the independent validation of electron candidates selected by calorimetric signatures, the rejection of false electron candidates that rise from accidental overlaps of low momentum charged particles with photon-induced electromagnetic showers in the calorimeter, and the identification of electrons arising from Dalitz decays or from photon conversions. The authors report on progress towards the development of an integrated transition radiation detector and charged particle tracker. Mechanical design and simulation of a detector has been pursued; a prototype device with 240 channels has been constructed and tested. Innovative construction techniques have been developed

Baseline gas turbine development program. Seventeenth quarterly progress report

Energy Technology Data Exchange (ETDEWEB)

Schmidt, F W; Wagner, C E

1977-01-31

Progress is reported for a program whose goals are to demonstrate an experimental upgraded gas turbine powered automobile which meets the 1978 Federal Emissions Standards, has significantly improved fuel economy, and is competitive in performance, reliability, and potential manufacturing cost with the conventional piston engine powered, compact-size American automobile. Initial running of the upgraded engine took place on July 13, 1976. The engine has proved to be mechanically sound, but has also been seriously deficient in power. Principal program effort has therefore been in the area of diagnostic testing and corrective development. To date, three upgraded engines have been assembled and run in the test cell. Engine 2 was installed in an upgraded vehicle and became operational on January 25, 1977. Special diagnostic instrumentation was installed on Engine 3 to evaluate the compressor, turbine, and hot engine leakage. It was determined that the power deficiency was principally due to problems in the compressor and first stage turbine areas and during this quarter several corrective changes have been initiated. Parts for a fourth engine being built for NASA Lewis have been shipped to NASA for installation of special instrumentation.

Recent progress in fusion gyrotron development

International Nuclear Information System (INIS)

Shively, J.F.; Stone, D.S.

1981-01-01

The gyrotron, a microwave tube capable of producing high power output at millimeter wavelengths, has recently found applications for electron cyclotron resonance heating of plasmas in controlled thermonuclear fusion reactor experiments. This paper describes work in progress to develop a gyrotron oscillator to deliver 200 kW CW at 60 GHz (/lambda/sub //. 5 mm). A pulsed oscillator is described which produced over 200 kw peak power. A CW oscillator is under construction. The latest experimental results are presented

Technology development, evaluation, and application (TDEA) FY 1997 progress report

Energy Technology Data Exchange (ETDEWEB)

Hoffman, L.G.

1998-05-01

The public expects that the Los Alamos National Laboratory (LANL) will operate in a manner that prevents negative impacts to the environment and protects the safety and health of its employees and the public. To achieve this goal within budget, the Department of Energy (DOE) and LANL must develop new and improved environment, safety, and health (ES and H) technologies and implement innovative, more cost-effective ES and H approaches to operations. In FY95, the Environment, Safety, and Health (ESH) Division initiated a Technology Development, Evaluation, and Application (TDEA) program. The purpose of this unique program is to test and develop technologies that solve LANL ES and H problems and improve the safety of LANL operations. This progress report presents the results of 10 projects funded in FY97 by the TDEA Committee of the Environment, Safety, and Health Division. Products generated from the projects funded in FY97 included implementation of radiation worker dosimetric monitoring systems (two); evaluation and validation of cost-effective animal-tracking systems for environmental studies (two); evaluation of personal protective equipment (two); and development of a method for optimal placement of continuous air monitors in the workplace.

Technology development, evaluation, and application (TDEA) FY 1997 progress report

International Nuclear Information System (INIS)

Hoffman, L.G.

1998-05-01

The public expects that the Los Alamos National Laboratory (LANL) will operate in a manner that prevents negative impacts to the environment and protects the safety and health of its employees and the public. To achieve this goal within budget, the Department of Energy (DOE) and LANL must develop new and improved environment, safety, and health (ES and H) technologies and implement innovative, more cost-effective ES and H approaches to operations. In FY95, the Environment, Safety, and Health (ESH) Division initiated a Technology Development, Evaluation, and Application (TDEA) program. The purpose of this unique program is to test and develop technologies that solve LANL ES and H problems and improve the safety of LANL operations. This progress report presents the results of 10 projects funded in FY97 by the TDEA Committee of the Environment, Safety, and Health Division. Products generated from the projects funded in FY97 included implementation of radiation worker dosimetric monitoring systems (two); evaluation and validation of cost-effective animal-tracking systems for environmental studies (two); evaluation of personal protective equipment (two); and development of a method for optimal placement of continuous air monitors in the workplace

Progress report on fish counting on the Rivers Itchen and Test

OpenAIRE

Welton, J.S.

1982-01-01

This progress report summarises work on NSHEB Mark 10 fish counters which are installed at Woodmill on the River Itchen and Nurseling Mill and Connegar Bridge on the River Test. Counters are evaluated and salmon behaviour regarding the counters examined. The report includes a a list of equipment needed for the efficient running of the project in the future.

Progress and Strategies for Testing of Materials for Solar Panels

Energy Technology Data Exchange (ETDEWEB)

Kurtz, Sarah

2017-04-25

Accelerated testing is key to confident launch of a new product. However, for new products like solar panels, the best approach is not always clear. The challenge for materials manufacturers is that test times can be long. Also, small-coupon testing may not predict the behavior in the full-size module, but testing of the full-size module is too expensive. As a result, solar panel test standards like IEC 61215 are useful, but are not sufficient. Material manufacturers have needed to define their own test protocols. This presentation will review some historical data (e.g., data show that manufacturers are making great progress toward reducing encapsulant discoloration) and describe advances in material testing (for example, new techniques are being demonstrated on how to more quantitatively assess adhesion, detect tendency for delamination, and understand how encapsulant properties affect other properties like cracking of cells). The International PV Quality Assurance Task Force has been researching climate-specific weathering tests toward the goal of defining international standards that would simplify qualification and quality assurance testing for materials. The status of these tests and the strategies for how to organize these standards to best meet the needs of the industry will be discussed.

The Chip-Scale Atomic Clock - Recent Development Progress

Science.gov (United States)

2004-09-01

35th Annual Precise Time and Time Interval (PTTI) Meeting 467 THE CHIP-SCALE ATOMIC CLOCK – RECENT DEVELOPMENT PROGRESS R. Lutwak ...1] R. Lutwak , et al., 2003, “The Chip-Scale Atomic Clock – Coherent Population Trapping vs. Conventional Interrogation,” in

Progress on development of nuclear power in Japan

International Nuclear Information System (INIS)

Anon.

2000-01-01

Since three Laws on the nuclear power were published 45 years has passed. Now, development on nuclear power in Japan is at an emergent state. In Japan, 51 units of commercial nuclear reactors with 44.917 GW are in operation, occupy about 37% of total electric power generation, and is positioned at an essential basic energy source supporting economical society in Japan. However, an accident occurred at Tokai Works of the JCO Co., Ltd., one of the uranium reconversion company, on September 30, 1999, was the first critical accident in Japan, and became the worst case in history on development of nuclear power in Japan, because of forming three heavy radiation disabled persons (One of them was dead) in its operators. This was a big crisis with relation to existence on development of nuclear power in Japan, by which anxiety and distrust of the Japanese against the nuclear power were amplified rapidly. On the other side, for Japan short in energy sources and of a big energy consumption, in order to intend for a long term to carry out energy security, global environmental conservation, and sustainable maintenance of essential growth, it remains to be one of important optional methods to further promote nuclear power generation and to establish nuclear fuel cycle. Here were described on progress on peaceful applications of nuclear power in Japan, progress on the field of nuclear power in Japan (from 1955 to 1999), progress on Tokai nuclear power station, introduction of nuclear power generation and effort on its domestic production. (G.K.)

Development of a psychological test to diagnose abilities required for successful learning medicine

Directory of Open Access Journals (Sweden)

H.-W. Gessmann

2014-08-01

Full Text Available We substantiate the necessity of psychological tools aimed at diagnostics of the capabilities for successful learning in medical university, and show the progress of its development. The questionnaire is developed based on the U.S. and European success tests, and its design meets the famous “test for medical professions” (TMS. “Kostroma test for medical professions” (KTMP is not a translation or adaptation of TMS to Russian conditions. It will be re-designed with new test items based on the principles of classical test construction. Creating scientifically based methods of psychological diagnosis of general cognitive ability is a prerequisite for the successful solution of a wide range of research and practical issues related to improving the effectiveness of education and training programs.

Development of a 20 MeV Dielectric-Loaded Test Accelerator

International Nuclear Information System (INIS)

Gold, Steven H.; Fliflet, Arne W.; Lombardi, Marcie; Kinkead, Allen K.; Gai, Wei; Power, John G.; Konecny, Richard; Long, Jidong; Jing, Chunguang; Tantawi, Sami G.; Nantista, Christopher D.; Bruce, Ralph W.; Lewis, David III

2006-01-01

This paper presents a progress report on a joint project by the Naval Research Laboratory (NRL) and Argonne National Laboratory (ANL), in collaboration with the Stanford Linear Accelerator Center (SLAC), to develop a dielectric-loaded test accelerator in the magnicon facility at NRL. The accelerator will be powered by an experimental 11.424-GHz magnicon amplifier that presently produces 25 MW of output power in a ∼250-ns pulse at up to 10 Hz. The accelerator will include a 5-MeV electron injector originally developed at the Tsinghua University in Beijing, China, and can incorporate DLA structures up to 0.5 m in length. The DLA structures are being developed by ANL, and shorter test structures fabricated from a variety of dielectric materials have undergone testing at NRL at gradients up to ∼8 MV/m. SLAC has developed components to distribute the power from the two magnicon output arms to the injector and to the DLA accelerating structure with separate control of the power ratio and relative phase. RWBruce Associates, Inc., working with NRL, has investigated means to join short ceramic sections into a continuous accelerator tube by a brazing process using an intense 83-GHz beam. The installation and testing of the first dielectric-loaded test accelerator, including injector, DLA test structure, and spectrometer, should take place within the next year

Final Progress Report: Developing Ethical Practices for Genetics Testing in the Workplace

Energy Technology Data Exchange (ETDEWEB)

Laura Roberts, MD; Teddy Warner, PhD

2008-05-14

Our multidisciplinary research team for this project involved collaboration between the Department of Psychiatry and Behavioral Medicine at the Medical College of Wisconsin (MCW) and the Department of Family and Community Medicine at the University of New Mexico Health Sciences Center (UNM HSC). Our research team in Wisconsin was led by Laura Roberts, M.D., Principal Investigator, and included Scott Helberg, MLS (Project Coordinator), Kate Green Hammond, Ph.D. (Consultant), Krisy Edenharder (Research Coordinator), and Mark Talatzko (Research Assistant). Our New Mexico-based team was led by Teddy Warner, Ph.D., Co-Principal Investigator and UNM Site Principal Investigator, and included Suzanne Roybal (Project Assistant), Darlyn Mabon (Project Assistant), Kate Green Hammond, PhD (Senior Research Scientist on the UNM team from 2004 until January, 2007), and Paulette Christopher (Research Assistant). In addition, computer technical and web support for the web-based survey conducted on a secure server at the University of New Mexico was provided by Kevin Wiley and Kim Hagen of the Systems and Programming Team of the Health Sciences Center Library and Information Center. We stated 3 aims in the grant proposal: (1) To collect web survey reports of the ethical perspectives, concerns, preferences and decision-making related to genetic testing using surveys from employees at: (a) Los Alamos National Laboratory (LANL); (b) Sandia National Laboratories (SNL); and (c) the University of New Mexico Health Sciences Center (UNMHSC); (2) To perform an extensive literature search and the extant survey data to develop evidence-based policy recommendations for ethically sound genetic testing associated with research and occupational health activities in the workplace; and, (3) To host a conference at the Medical College of Wisconsin to provide employers, workers, health professionals, researchers, the public, and the media an opportunity to consider ethical issues involved in genetic

Development of a Conceptual Model of Disease Progression for Use in Economic Modeling of Chronic Obstructive Pulmonary Disease.

Science.gov (United States)

Tabberer, Maggie; Gonzalez-McQuire, Sebastian; Muellerova, Hana; Briggs, Andrew H; Rutten-van Mölken, Maureen P M H; Chambers, Mike; Lomas, David A

2017-05-01

To develop and validate a new conceptual model (CM) of chronic obstructive pulmonary disease (COPD) for use in disease progression and economic modeling. The CM identifies and describes qualitative associations between disease attributes, progression and outcomes. A literature review was performed to identify any published CMs or literature reporting the impact and association of COPD disease attributes with outcomes. After critical analysis of the literature, a Steering Group of experts from the disciplines of health economics, epidemiology and clinical medicine was convened to develop a draft CM, which was refined using a Delphi process. The refined CM was validated by testing for associations between attributes using data from the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE). Disease progression attributes included in the final CM were history and occurrence of exacerbations, lung function, exercise capacity, signs and symptoms (cough, sputum, dyspnea), cardiovascular disease comorbidities, 'other' comorbidities (including depression), body composition (body mass index), fibrinogen as a biomarker, smoking and demographic characteristics (age, gender). Mortality and health-related quality of life were determined to be the most relevant final outcome measures for this model, intended to be the foundation of an economic model of COPD. The CM is being used as the foundation for developing a new COPD model of disease progression and to provide a framework for the analysis of patient-level data. The CM is available as a reference for the implementation of further disease progression and economic models.

The Tourism–Development Nexus in sub-Saharan Africa: Progress ...

African Journals Online (AJOL)

The Tourism–Development Nexus in sub-Saharan Africa: Progress and Prospects. ... discussed concerning the impacts of differentiated kinds of tourism: tourism and ... finally, questions around tourism, climate change and the green economy.

Test-retest reliability of the Progressive Isoinertial Lifting Evaluation (PILE).

Science.gov (United States)

Lygren, Hildegunn; Dragesund, Tove; Joensen, Jón; Ask, Tove; Moe-Nilssen, Rolf

2005-05-01

A repeated measures single group design. To investigate test-retest reliability of Progressive Isoinertial Lifting Evaluation on patients with long lasting musculoskeletal problems related to the lumbar spine. Test-retest reliability has been satisfactory in healthy men. Test-retest reliability for clinical populations has not been reported. A total of 31 patients (17 women and 14 men) with long lasting low back pain participated in the study. The patients were tested twice at an interval of 2 days and at the same time of the day. The heaviest load that the patient could lift 4 times was used as outcome measure. The error of measurement indicates that the true result in 95% of cases will be within +/-4.5 kg from the measured value, while the difference between 2 measurements in 95% of cases will be less than 6.4 kg. Intra-class correlation (1,1) was 0.91. Relative test-retest reliability was high assessed by intra-class correlation, but absolute measurement variability reported as the smallest detectable difference has relevance for the interpretation of clinical test results and should also be considered.

Progress report on research and development in 1991, Institute of Reactor Development, KfK

International Nuclear Information System (INIS)

1992-03-01

Progress report on research and development in 1991 Institute of Reactor Development. The papers on nuclear fusion concentrate on the design and material selection for highly stressed components as well as on safety matters. Experiments with the thermomechanical behaviour of different material samples continued, with selected materials being put to a load of up to 10 000 cycles. Carbon fiber reinforced composite materials proved to be very stable as regards their form, and unproblematic from a thermomechanical viewpoint, even at high cycle numbers. The papers on handling techniques refer to specific requirements of nuclear fusion with applications at JET and NET, to the development of system solutions to be used in the classical industrial area, and to standardization accompanying the developments. The system for physical simulation of working scenes was refined and extended by models for the prototype of a testing device to be handled in the torus of a fusion machine. Control of the articulated boom has been further improved. Under the nuclear safety research project, studies have been made of the dynamic behaviour of fast reactors under incident conditions, of the possible propagation of local cooling incidents in the reactor core as well as of core monitoring. The further development of physical models and computer programs on the dynamic behaviour of fast sodium-cooled reactors has been supported by experimental results. (orig./DG) [de

12 tesla test coil. Annual progress report

International Nuclear Information System (INIS)

1979-01-01

The Plasma Fusion Center at MIT has been charged with responsibility for the design, development, fabrication and test operation of a Niobium-3-Tin Superconducting Test Coil. Research is described on DOE's 12 tesla coil demonstration program in which several one-meter diameter superconducting test coils will be inserted and tested in DOE's High Field Test Facility at the Lawrence Livermore Laboratories. The work was initiated at the start of FY 79. FY 79 saw the completion of our Preliminary Design and the initiation of three (3) subcontracts: (1) Westinghouse review of the Preliminary Design, (II) Supercon, Inc. development of a tubular copper matrix, Nb 3 Sn Superconductor and (III) Airco optimization of the LCP-W Nb 3 Sn superconductor for 12T service. In addition, Airco was charged with the production of a 1000 foot length of model 15,000A conductor. Coil winding exercises were initiated at the Everson Electric Company

Fibrosis progression under maintenance interferon in hepatitis C is better detected by blood test than liver morphometry.

Science.gov (United States)

Calès, P; Zarski, J P; Chapplain, J Marc; Bertrais, S; Sturm, N; Michelet, C; Babany, G; Chaigneau, J; Eddine Charaf, M

2012-02-01

We evaluated whether quantitative measurements of liver fibrosis with recently developed diagnostics outperform histological staging in detecting natural or interferon-induced changes. We compared Metavir staging, morphometry (area and fractal dimension) and six blood tests in 157 patients with chronic hepatitis C from two trials testing maintenance interferon for 96 weeks. Paired liver biopsies and blood tests were available for 101 patients, and there was a significant improvement in Metavir activity and a significant increase in blood tests reflecting fibrosis quantity in patients treated with interferon when compared with controls - all per cent changes in histological fibrosis measures were significantly increased in F1 vs F2-4 stages only in the interferon group. For the whole population studied between weeks 0 and 96, there was significant progression only in the area of fibrosis (AOF) (P = 0.026), FibroMeter (P = 0.020) and CirrhoMeter (P = 0.003). With regards to dynamic reproducibility, agreement was good (r(ic) ≥ 0.72) only for Metavir fibrosis score, FibroMeter and CirrhoMeter. The per cent change in AOF was significantly higher than that of fractal dimension (P = 0.003) or Metavir fibrosis score (P = 0.015). CirrhoMeter was the only blood test with a change significantly higher than that of AOF (P = 0.039). AOF and two blood tests, reflecting fibrosis quantity, have high sensitivity and/or reproducibility permitting the detection of a small progression in liver fibrosis over two years. A blood test reflecting fibrosis quantity is more sensitive and reproducible than morphometry. The study also shows that maintenance interferon does not improve fibrosis, whatever its stage. © 2011 Blackwell Publishing Ltd.

Comparison of Individual Performance in Intelligence Tests WAIS III and RPM (Raven's Progressive Matrices)

OpenAIRE

Petrů, Vít

2017-01-01

This thesis deals with replacement of performative scale of Wechsler Adult Intelligence Scale (3rd revision) through Raven's Standard Progressive Matrices and Advanced Progressive Matrices. In the theoretical part introduces the concepts of intelligence, approaches to its exploration and intelligence tests. The theoretical part is also devoted to the description of the used methods and presents an overview of the research on a similar theme as this work. In the empirical part of the thesis is...

Progress on the Fabrication Methods Development for the Korean Test Blanket Module First Wall in the ITER

International Nuclear Information System (INIS)

Lee, Dong Won; Kim, Suk Kwon; Bae, Young Dug; Yoon, Jae Sung; Cho, Seung Yon

2010-01-01

A Korean helium cooled molten lithium (HCML) test blanket module (TBM) has been designed to be tested in the International Thermonuclear Experimental Reactor (ITER) TBM and related fabrication methods have been developed especially for the purpose of joining. Since the first wall (FW) of the HCML TBM is composed of a beryllium (Be) as an armor material and a FMS as a structural one, joining with Be to FMS and FMS to FMS should be developed in order to fabricate it

Development of a 20 MeV Dielectric-Loaded Accelerator Test Facility

International Nuclear Information System (INIS)

Gold, Steven H.; Fliflet, Arne W.; Kinkead, Allen K.; Gai Wei; Power, John G.; Konecny, Richard; Jing Chunguang; Tantawi, Sami G.; Nantista, Christopher D.; Hu, Y.; Chen, H.; Tang, C.; Lin, Y.; Bruce, Ralph W.; Bruce, Robert L.; Lewis, David III

2004-01-01

This paper describes a joint project by the Naval Research Laboratory (NRL) and Argonne National Laboratory (ANL), in collaboration with the StanFord Linear Accelerator Center (SLAC), to develop a dielectric-loaded accelerator (DLA) test facility powered by a high-power 11.424-GHz magnicon amplifier. The magnicon can presently produce 25 MW of output power in a 250-ns pulse at 10 Hz, and efforts are in progress to increase this to 50 MW. The facility will include a 5 MeV electron injector being developed by the Accelerator Laboratory of Tsinghua University in Beijing, China. The DLA test structures are being developed by ANL, and some have undergone testing at NRL at gradients up to ∼8 MV/m. SLAC is developing a means to combine the two magnicon output arms, and to drive an injector and accelerator with separate control of the power ratio and relative phase. RWBruce Associates, Inc., working with NRL, is developing a means to join short ceramic sections into a continuous accelerator tube by ceramic brazing using an intense millimeter-wave beam. The installation and testing of the first dielectric-loaded test accelerator, including injector, DLA structure, and spectrometer, should take place within the next year. The facility will be used for testing DLA structures using a variety of materials and configurations, and also for testing other X-band accelerator concepts. The initial goal is to produce a compact 20 MeV dielectric-loaded test accelerator

US Department of Energy Environment, Safety and Health Progress Assessment of the Nevada Test Site

Energy Technology Data Exchange (ETDEWEB)

1992-08-01

This report documents the result of the US Department of Energy (DOE) Environment, Safety, and Health (ES&H) Progress Assessment of the Nevada Test Site (NTS), Nye County, Nevada. The assessment, which was conducted from July 20 through August 4, 1992, included a selective review of the ES&H management systems and progress of the responsible DOE Headquarters Program Offices; the DOE Nevada Field Office (NV); and the site contractors. The ES&H Progress Assessments are part of the Secretary of Energy`s continuing effort to institutionalize line management accountability and the self-assessment process throughout DOE and its contractor organizations. This report presents a summary of issues and progress in the areas of environment, safety and health, and management.

US Department of Energy Environment, Safety and Health Progress Assessment of the Nevada Test Site

International Nuclear Information System (INIS)

1992-08-01

This report documents the result of the US Department of Energy (DOE) Environment, Safety, and Health (ES ampersand H) Progress Assessment of the Nevada Test Site (NTS), Nye County, Nevada. The assessment, which was conducted from July 20 through August 4, 1992, included a selective review of the ES ampersand H management systems and progress of the responsible DOE Headquarters Program Offices; the DOE Nevada Field Office (NV); and the site contractors. The ES ampersand H Progress Assessments are part of the Secretary of Energy's continuing effort to institutionalize line management accountability and the self-assessment process throughout DOE and its contractor organizations. This report presents a summary of issues and progress in the areas of environment, safety and health, and management

Test facility for the development of 150-keV, multi-megawatt neutral beam systems

International Nuclear Information System (INIS)

Haughian, W.; Baker, W.R.; Biagi, L.A.; Hopkins, D.B.

1975-11-01

The next generation of CTR experiments, such as the Tokamak Fusion Test Reactor (TFTR), will require neutral-beam injection systems that produce multi-megawatt, 120-keV deuterium-beam pulses of 0.5-second duration. Since present injection systems are operating in the 10- to 40-keV range, an intensive development effort is in progress to meet a 150-keV requirement. The vacuum system and power supplies that make up a test facility to be used in the development of these injectors are described

Progress in control and data acquisition for the ITER neutral beam test facility

Energy Technology Data Exchange (ETDEWEB)

Luchetta, Adriano, E-mail: adriano.luchetta@igi.cnr.it [Consorzio RFX, Euratom-ENEA Association, Padova (Italy); Manduchi, Gabriele; Taliercio, Cesare; Soppelsa, Anton [Consorzio RFX, Euratom-ENEA Association, Padova (Italy); Paolucci, Francesco; Sartori, Filippo [Fusion for Energy, Barcelona (Spain); Barbato, Paolo; Capobianco, Roberto; Breda, Mauro; Molon, Federico; Moressa, Modesto; Polato, Sandro; Simionato, Paola; Zampiva, Enrico [Consorzio RFX, Euratom-ENEA Association, Padova (Italy)

2013-10-15

Highlights: ► An ion source experiment, referred to as SPIDER, is under construction in the ITER neutral beam test facility. ► The progress in designing and testing the SPIDER control and data acquisition system is reported. ► An original approach is proposed in using ITER CODAC and non-ITER CODAC technology. -- Abstract: SPIDER, the ion source test bed in the ITER neutral beam test facility, is under construction and its operation is expected to start in 2014. Control and data acquisition for SPIDER are undergoing final design. SPIDER CODAS, as the control and data acquisition system is referred to, is requested to manage 25 plant units, to acquire 1000 analogue signals with sampling rates ranging from a few S/s to 10 MS/s, to acquire images with up to 100 frames per second, to operate with long pulses lasting up to 1 h, and to sustain 200 MB/s data throughput into the data archive with an annual data storage amount of up to 50 TB. SPIDER CODAS software architecture integrates three open-source software frameworks each addressing specific system requirements. Slow control exploits the synergy among EPICS and Siemens S7 programmable controllers. Data handling is by MDSplus a data-centric framework that is geared towards the collection and organization of scientific data. Diagnostics based on imaging drive the design of data throughput and archive size. Fast control is implemented by using MARTe, a data-driven, object-oriented, real-time environment. The paper will describe in detail the progress of the system hardware and software architecture and will show how the software frameworks interact to provide the functions requested by SPIDER CODAS. The paper will focus on how the performance requirements can be met with the described SPIDER CODAS architecture, describing the progress achieved by carrying out prototyping activities.

Progress in control and data acquisition for the ITER neutral beam test facility

International Nuclear Information System (INIS)

Luchetta, Adriano; Manduchi, Gabriele; Taliercio, Cesare; Soppelsa, Anton; Paolucci, Francesco; Sartori, Filippo; Barbato, Paolo; Capobianco, Roberto; Breda, Mauro; Molon, Federico; Moressa, Modesto; Polato, Sandro; Simionato, Paola; Zampiva, Enrico

2013-01-01

Highlights: ► An ion source experiment, referred to as SPIDER, is under construction in the ITER neutral beam test facility. ► The progress in designing and testing the SPIDER control and data acquisition system is reported. ► An original approach is proposed in using ITER CODAC and non-ITER CODAC technology. -- Abstract: SPIDER, the ion source test bed in the ITER neutral beam test facility, is under construction and its operation is expected to start in 2014. Control and data acquisition for SPIDER are undergoing final design. SPIDER CODAS, as the control and data acquisition system is referred to, is requested to manage 25 plant units, to acquire 1000 analogue signals with sampling rates ranging from a few S/s to 10 MS/s, to acquire images with up to 100 frames per second, to operate with long pulses lasting up to 1 h, and to sustain 200 MB/s data throughput into the data archive with an annual data storage amount of up to 50 TB. SPIDER CODAS software architecture integrates three open-source software frameworks each addressing specific system requirements. Slow control exploits the synergy among EPICS and Siemens S7 programmable controllers. Data handling is by MDSplus a data-centric framework that is geared towards the collection and organization of scientific data. Diagnostics based on imaging drive the design of data throughput and archive size. Fast control is implemented by using MARTe, a data-driven, object-oriented, real-time environment. The paper will describe in detail the progress of the system hardware and software architecture and will show how the software frameworks interact to provide the functions requested by SPIDER CODAS. The paper will focus on how the performance requirements can be met with the described SPIDER CODAS architecture, describing the progress achieved by carrying out prototyping activities

Teaching the Possible: Justice-Oriented Professional Development for Progressive Educators

Directory of Open Access Journals (Sweden)

Mollie A. Gambone

2017-12-01

Full Text Available Providing justice-oriented professional development for progressive educators has historically been a site of tension. To address this, The Progressive Education Network (PEN, the leading professional organization of progressive educators in the United States, brought together over 800 educators for its 2015 National Conference, titled “Teaching the Possible: Access, Equity, and Activism!” This article documents PEN’s framework for facilitating an opportunity for educators to engage in dialogue about areas of social injustice throughout education and within their own schools. Findings derived from a discourse analysis of workshop abstracts published in the conference program suggest that the conference provided professional development in three areas: 1 workshops were designed by teachers to share useful methodologies relevant to the conference theme with other teachers; 2 workshops encouraged attendees to critically examine how problematic issues in education are commonly understood, then reframe them to consider the issues from different perspectives; 3 doing so gave rise to an understanding that in order to imagine innovative solutions to systemic problems, one must first be able understand how different groups of individuals experience the problems. This analysis establishes that by aligning the conference with a critical, justice-oriented theme, the workshops were designed to provide attendees with opportunities to investigate their own roles in producing, changing, and interpreting socially-just learning and teaching in their own school contexts. This is important because it advances the study of equitable access to progressive pedagogy, while at the same time utilizing Desimone’s (2009 framework for judging effective professional development for teachers.

Specimen aspect ratio and progressive field strain development of sandstone under uniaxial compression by three-dimensional digital image correlation

Directory of Open Access Journals (Sweden)

H. Munoz

2017-08-01

Full Text Available The complete stress–strain characteristics of sandstone specimens were investigated in a series of quasi-static monotonic uniaxial compression tests. Strain patterns development during pre- and post-peak behaviours in specimens with different aspect ratios was also examined. Peak stress, post-peak portion of stress–strain, brittleness, characteristics of progressive localisation and field strain patterns development were affected at different extents by specimen aspect ratio. Strain patterns of the rocks were obtained by applying three-dimensional (3D digital image correlation (DIC technique. Unlike conventional strain measurement using strain gauges attached to specimen, 3D DIC allowed not only measuring large strains, but more importantly, mapping the development of field strain throughout the compression test, i.e. in pre- and post-peak regimes. Field strain development in the surface of rock specimen suggests that strain starts localising progressively and develops at a lower rate in pre-peak regime. However, in post-peak regime, strains increase at different rates as local deformations take place at different extents in the vicinity and outside the localised zone. The extent of localised strains together with the rate of strain localisation is associated with the increase in rate of strength degradation. Strain localisation and local inelastic unloading outside the localised zone both feature post-peak regime.

FY 1997 Progress report on tube propagation testing of tank waste using the PRSST

International Nuclear Information System (INIS)

Bechtold, D.B.

1997-01-01

The subject of this FY 1997 progress report is tube propagation tests of actual, dried tank waste to verify the contact temperature ignition (CTI) criterion for point-source ignition in the Hanford Site waste tanks. Testing is in support of the Organic Tanks Safety Project and will help resolve safety issues with waste containing organic constituents. In FY 1997, improvements were made to the laboratory apparatus and procedures for conducting the testing, and the final testing strategy was formulated. The strategy lays out details of the tests to be performed, samples to be tested, and modes of reporting results

Fear of progression in chronic diseases: psychometric properties of the Fear of Progression Questionnaire.

Science.gov (United States)

Herschbach, Peter; Berg, Petra; Dankert, Andrea; Duran, Gabriele; Engst-Hastreiter, Ursula; Waadt, Sabine; Keller, Monika; Ukat, Robert; Henrich, Gerhard

2005-06-01

The aim of this study was the development and psychometric testing of a new psychological questionnaire to measure the fear of progression (FoP) in chronically ill patients (cancer, diabetes mellitus and rheumatic diseases). The Fear of Progression Questionnaire (FoP-Q) was developed in four phases: (1) generation of items (65 interviews); (2) reduction of items--the initial version of the questionnaire (87 items) was presented to 411 patients, to construct subscales and test the reliability; (3) testing the convergent and discriminative validity of the reduced test version (43 items) within a new sample (n=439); (4) translation--German to English. The scale comprised five factors (Cronbach's alpha >.70): affective reactions (13 items), partnership/family (7), occupation (7), loss of autonomy (7) and coping with anxiety (9). The test-retest reliability coefficients varied between .77 and .94. There was only a medium relationship to traditional anxiety scales. This is an indication of the independence of the FoP. Significant relationships between the FoP-Q and the patient's illness behaviour indicate discriminative validity. The FoP-Q is a new and unique questionnaire developed for the chronically ill. A major problem and source of stress for this patient group has been measuring both specifically and economically the FoP of an illness. The FoP-Q was designed to resolve this problem, fulfill this need and reduce this stress.

Manufacturing of cells and stacks for SOFC development, test and demonstration projects and SOFC hotbox design development

Energy Technology Data Exchange (ETDEWEB)

2008-09-15

The purpose of this project is to support the continued SOFC development through manufacturing process optimization and manufacturing of SOFC cells and stacks. These cells and stacks will serve as a necessary base for the development activities and for the establishment of a number of test and demonstration activities. The manufacture will also help provide operating experience and reduce manufacturing cost. Another main focus of the manufacturing is to assure technical improvements and reliability. It is imperative to the eventual success of the technology that test and demonstration is carried out in the pre-market conditions that will exist for the next years in the three market segments targeted by TOFC (Distributed generation, micro CHP and APU incl. marine APU). Finally, the project also includes development activities focusing on the stack-system interface (hotbox design development) and on dealing with transients and start up and shut down times, which is of particular importance for APU and micro CHP applications. Three topics are addressed:1) Cell manufacture, including production development, capacity lift and manuf. of cells for test and demonstration; 2) Stack manufacture and test, including a test facility, stack manuf. and test of stacks in a system at HCV; 3) Hotbox design development, including design, prototype construction and testing. The progress of this project is documented. Major achievements are successful manufacture of adequate amounts of cells and stacks according to the application. Furthermore significant over-performance in design, construction and test of a methanol based hotbox prototype as well as publication of this. (au)

Experimental tests of general relativity: recent progress and future directions

International Nuclear Information System (INIS)

Turyshev, S G

2009-01-01

Einstein's general theory of relativity is the standard theory of gravity, especially where the needs of astronomy, astrophysics, cosmology, and fundamental physics are concerned. As such, this theory is used for many practical purposes involving spacecraft navigation, geodesy, and time transfer. We review the foundations of general relativity, discuss recent progress in tests of relativistic gravity, and present motivations for the new generation of high-accuracy tests of new physics beyond general relativity. Space-based experiments in fundamental physics are presently capable of uniquely addressing important questions related to the fundamental laws of nature. We discuss the advances in our understanding of fundamental physics that are anticipated in the near future and evaluate the discovery potential of a number of recently proposed space-based gravitational experiments. (reviews of topical problems)

Assessing progress in the development of safety culture

International Nuclear Information System (INIS)

Rotaru, I.; Ghita, S.; Biro, L.

2002-01-01

This paper is focussed on the organizational culture and learning processes required for the implementation of all aspects of safety culture. There is no prescriptive formula for improving safety culture. However, some common characteristics and practices are emerging that can be adopted by organizations in order to make progress. The paper refers to some approaches that have been successful in a number of countries. The experience of the international nuclear industry in the development and improvement of safety culture could be extended and found useful in other nuclear activities, irrespective of scale. The examples given of specific practice cover a wide range of activities including analysis of events, the regulatory approach on safety culture, employee participation and safety performance measures. Many of these practices may be relevant to smaller organizations and could contribute to improving safety culture, whatever the size of the organization. The most effective approach is to pursue a range of practices that can be mutually supportive in the development of a progressive safety culture, supported by professional standards, organizational and management commitment. Some guidance is also given on the assessment of safety culture and on the detection of a weakening safety culture. Few suggestions for accelerating the safety culture development and improvement process are also provided. (author)

QUARTERLY PROGRESS REPORT JANUARY, FEBRUARY, MARCH, 1968 REACTOR FUELS AND MATERIALS DEVELOPMENT PROGRAMS FOR FUELS AND MATERIALS BRANCH OF USAEC DIVISION OF REACTOR DEVELOPMENT AND TECHNOLOGY

Energy Technology Data Exchange (ETDEWEB)

Cadwell, J. J.; de Halas, D. R.; Nightingale, R. E.; Worlton, D. C.

1968-06-01

Progress is reported in these areas: nuclear graphite; fuel development for gas-cooled reactors; HTGR graphite studies; nuclear ceramics; fast-reactor nitrides research; non-destructive testing; metallic fuels; basic swelling studies; ATR gas and water loop operation and maintenance; reactor fuels and materials; fast reactor dosimetry and damage analysis; and irradiation damage to reactor metals.

Chemistry research and development. Progress report, December 1978-May 1979

International Nuclear Information System (INIS)

Miner, F.J.

1980-01-01

Progress and activities are reported on component development, pilot plant development, and instrumentation and statistical systems. Specific items studied include processing of pond sludge, transport of radioactive materials and wastes, corrosion, decontamination and cleaning, fluidized-bed incineration, Pu contamination of soils, chemical analysis, radiometric analysis, security

Drivers of inequality in Millennium Development Goal progress: a statistical analysis.

Science.gov (United States)

Stuckler, David; Basu, Sanjay; McKee, Martin

2010-03-02

Many low- and middle-income countries are not on track to reach the public health targets set out in the Millennium Development Goals (MDGs). We evaluated whether differential progress towards health MDGs was associated with economic development, public health funding (both overall and as percentage of available domestic funds), or health system infrastructure. We also examined the impact of joint epidemics of HIV/AIDS and noncommunicable diseases (NCDs), which may limit the ability of households to address child mortality and increase risks of infectious diseases. We calculated each country's distance from its MDG goals for HIV/AIDS, tuberculosis, and infant and child mortality targets for the year 2005 using the United Nations MDG database for 227 countries from 1990 to the present. We studied the association of economic development (gross domestic product [GDP] per capita in purchasing-power-parity), the relative priority placed on health (health spending as a percentage of GDP), real health spending (health system expenditures in purchasing-power-parity), HIV/AIDS burden (prevalence rates among ages 15-49 y), and NCD burden (age-standardised chronic disease mortality rates), with measures of distance from attainment of health MDGs. To avoid spurious correlations that may exist simply because countries with high disease burdens would be expected to have low MDG progress, and to adjust for potential confounding arising from differences in countries' initial disease burdens, we analysed the variations in rates of change in MDG progress versus expected rates for each country. While economic development, health priority, health spending, and health infrastructure did not explain more than one-fifth of the differences in progress to health MDGs among countries, burdens of HIV and NCDs explained more than half of between-country inequalities in child mortality progress (R(2)-infant mortality = 0.57, R(2)-under 5 mortality = 0.54). HIV/AIDS and NCD burdens were also

Drivers of inequality in Millennium Development Goal progress: a statistical analysis.

Directory of Open Access Journals (Sweden)

David Stuckler

2010-03-01

Full Text Available Many low- and middle-income countries are not on track to reach the public health targets set out in the Millennium Development Goals (MDGs. We evaluated whether differential progress towards health MDGs was associated with economic development, public health funding (both overall and as percentage of available domestic funds, or health system infrastructure. We also examined the impact of joint epidemics of HIV/AIDS and noncommunicable diseases (NCDs, which may limit the ability of households to address child mortality and increase risks of infectious diseases.We calculated each country's distance from its MDG goals for HIV/AIDS, tuberculosis, and infant and child mortality targets for the year 2005 using the United Nations MDG database for 227 countries from 1990 to the present. We studied the association of economic development (gross domestic product [GDP] per capita in purchasing-power-parity, the relative priority placed on health (health spending as a percentage of GDP, real health spending (health system expenditures in purchasing-power-parity, HIV/AIDS burden (prevalence rates among ages 15-49 y, and NCD burden (age-standardised chronic disease mortality rates, with measures of distance from attainment of health MDGs. To avoid spurious correlations that may exist simply because countries with high disease burdens would be expected to have low MDG progress, and to adjust for potential confounding arising from differences in countries' initial disease burdens, we analysed the variations in rates of change in MDG progress versus expected rates for each country. While economic development, health priority, health spending, and health infrastructure did not explain more than one-fifth of the differences in progress to health MDGs among countries, burdens of HIV and NCDs explained more than half of between-country inequalities in child mortality progress (R(2-infant mortality = 0.57, R(2-under 5 mortality = 0.54. HIV/AIDS and NCD burdens were

Design and development of RF system for vertical test stand for characterization of superconducting RF cavities

International Nuclear Information System (INIS)

Mohania, Praveen; Rajput, Vikas; Baxy, Deodatta; Agrawal, Ankur; Mahawar, Ashish; Adarsh, Kunver; Singh, Pratap; Shrivastava, Purushottam

2011-01-01

RRCAT is developing a Vertical Test Stand (VTS) to test and qualify 1.3 GHz/650 MHz, SCRF Cavities in collaboration with Fermi National Accelerator Laboratory (FNAL) under Indian Institutions' Fermilab Collaboration. The technical details for VTS is being provided by FNAL, USA. The RF System of VTS needs to provide stable RF power to SCRF cavity with control of amplitude, relative phase and frequency. The incident, reflected, transmitted power and field decay time constant of the cavity are measured to evaluate cavity performance parameters (E, Qo). RF Power is supplied via 500 W Solid State amplifier, 1270-1310 MHz being developed by PHPMS, RRCAT. VTS system is controlled by PXI Platform and National Instruments LabVIEW software. Low Level RF (LLRF) system is used to track the cavity frequency using Phase Locked Loop (PLL). The system is comprised of several integrated functional modules which would be assembled, optimized, and tested separately. Required components and instruments have been identified and procurement for the same is underway. Inhouse development for the Solid State RF amplifier and instrument interfacing is in progress. This paper describes the progress on the development of the RF system for VTS. (author)

The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months.

Science.gov (United States)

Sosenko, Jay M; Skyler, Jay S; Beam, Craig A; Boulware, David; Mahon, Jeffrey L; Krischer, Jeffrey P; Greenbaum, Carla J; Rafkin, Lisa E; Matheson, Della; Herold, Kevan C; Palmer, Jerry P

2015-05-01

We developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D. The PS6M was developed from Diabetes Prevention Trial-Type 1 (DPT-1) data and tested in the TrialNet Pathway to Prevention Study (PTP). It is the difference between 6-month glucose sum values (30-120 min oral glucose tolerance test values) and values predicted for nonprogressors. The PS6M predicted T1D in the PTP (P 7.00 (P < 0.001 for all). The PS6M is an indicator of short-term glycemic progression to T1D that could be a useful tool for assessing preventive treatments and biomarkers. © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

Workforce Training and Economic Development Fund: 2015 Annual Progress Report

Science.gov (United States)

Iowa Department of Education, 2015

2015-01-01

The Department of Education, Division of Community Colleges, will annually provide the State Board of Education with The Workforce Training and Economic Development (WTED) Fund Annual Progress Report. Administration and oversight responsibility for the fund was transferred from the Iowa Economic Development Authority to the Iowa Department of…

LMFBR flexible pipe joint development program. Annual technical progress report, government fiscal year 1977

International Nuclear Information System (INIS)

1978-01-01

Currently, the ASME Boiler and Pressure Vessel Code does not allow the use of flexible pipe joints (bellows) in Section III, Class 1 reactor primary piping systems. Studies have shown that the primary piping loops of LMFBR's could be simplified by using these joints. This simplification translates directly into shorter primary piping runs and reduced costs for the primary piping system. Further cost savings result through reduced vault sizes and reduced containment building diameter. In addition, the use of flexible joints localizes the motions from thermally-induced piping growth into components which are specifically designed to accommodate this motion. This reduces the stress levels in the piping system and its components. It is thus economically and structurally important that flexible piping joints be available to the LMFBR designer. The overall objective of the Flexible Joint Program is to provide this availability. This will be accomplished through the development of ASME rules which allow the appropriate use of such joints in Section III, Class 1 piping systems and through the development and demonstration of construction methods which satisfy these rules. The rule development includes analytic and testing methodology formulations which will be supported by subscale bellows testing. The construction development and demonstration encompass the design, fabrication, and in-sodium testing of prototypical LMFBR plant-size flexible pipe joints which meet all ASME rule requirements. The satisfactory completion of these developmental goals will result in an approved flexible pipe joint design for the LMFBR. Progress is summarized in the following efforts undertaken during 1977 to accomplish these goals: (1) code case support, (2) engineering and design, (3) material development, (4) testing, and (5) manufacturing development

Progress in Development of an Airborne Turbulence Detection System

Science.gov (United States)

Hamilton, David W.; Proctor, Fred H.

2006-01-01

Aircraft encounters with turbulence are the leading cause of in-flight injuries (Tyrvanas 2003) and have occasionally resulted in passenger and crew fatalities. Most of these injuries are caused by sudden and unexpected encounters with severe turbulence in and around convective activity (Kaplan et al 2005). To alleviate this problem, the Turbulence Prediction and Warning Systems (TPAWS) element of NASA s Aviation Safety program has investigated technologies to detect and warn of hazardous in-flight turbulence. This effort has required the numerical modeling of atmospheric convection: 1) for characterizing convectively induced turbulence (CIT) environments, 2) for defining turbulence hazard metrics, and 3) as a means of providing realistic three-dimensional data sets that can be used to test and evaluate turbulence detection sensors. The data sets are being made available to industry and the FAA for certification of future airborne turbulence-detection systems (ATDS) with warning capability. Early in the TPAWS project, a radar-based ATDS was installed and flight tested on NASA s research aircraft, a B-757. This ATDS utilized new algorithms and hazard metrics that were developed for use with existing airborne predictive windshear radars, thus avoiding the installation of new hardware. This system was designed to detect and warn of hazardous CIT even in regions with weak radar reflectivity (i.e. 5-15 dBz). Results from an initial flight test of the ATDS were discussed in Hamilton and Proctor (2002a; 2002b). In companion papers (Proctor et al 2002a; 2002b), a numerical simulation of the most significant encounter from that flight test was presented. Since the presentation of these papers a second flight test has been conducted providing additional cases for examination. In this paper, we will present results from NASA s flight test and a numerical model simulation of a turbulence environment encountered on 30 April 2002. Progress leading towards FAA certification of

Progress in sensor performance testing, modeling and range prediction using the TOD method: an overview

Science.gov (United States)

Bijl, Piet; Hogervorst, Maarten A.; Toet, Alexander

2017-05-01

The Triangle Orientation Discrimination (TOD) methodology includes i) a widely applicable, accurate end-to-end EO/IR sensor test, ii) an image-based sensor system model and iii) a Target Acquisition (TA) range model. The method has been extensively validated against TA field performance for a wide variety of well- and under-sampled imagers, systems with advanced image processing techniques such as dynamic super resolution and local adaptive contrast enhancement, and sensors showing smear or noise drift, for both static and dynamic test stimuli and as a function of target contrast. Recently, significant progress has been made in various directions. Dedicated visual and NIR test charts for lab and field testing are available and thermal test benches are on the market. Automated sensor testing using an objective synthetic human observer is within reach. Both an analytical and an image-based TOD model have recently been developed and are being implemented in the European Target Acquisition model ECOMOS and in the EOSTAR TDA. Further, the methodology is being applied for design optimization of high-end security camera systems. Finally, results from a recent perception study suggest that DRI ranges for real targets can be predicted by replacing the relevant distinctive target features by TOD test patterns of the same characteristic size and contrast, enabling a new TA modeling approach. This paper provides an overview.

The Progressive Development of Environmental Education in Sweden and Denmark

Science.gov (United States)

Breiting, Soren; Wickenberg, Per

2010-01-01

Our paper traces the history and progressive development of environmental education and education for sustainable development (ESD) in Sweden and Denmark. Our main focus is on work in primary and lower secondary schools as part of a search for trends of international interest related to the conceptualisation and practice of environmental education…

Progress towards the development of SH2 domain inhibitors.

Science.gov (United States)

Kraskouskaya, Dziyana; Duodu, Eugenia; Arpin, Carolynn C; Gunning, Patrick T

2013-04-21

Src homology 2 (SH2) domains are 100 amino acid modular units, which recognize and bind to tyrosyl-phosphorylated peptide sequences on their target proteins, and thereby mediate intracellular protein-protein interactions. This review summarizes the progress towards the development of synthetic agents that disrupt the function of the SH2 domains in different proteins as well as the clinical relevance of targeting a specific SH2 domain. Since 1986, SH2 domains have been identified in over 110 human proteins, including kinases, transcription factors, and adaptor proteins. A number of these proteins are over-activated in many diseases, including cancer, and their function is highly dependent on their SH2 domain. Thus, inhibition of a protein's function through disrupting that of its SH2 domain has emerged as a promising approach towards the development of novel therapeutic modalities. Although targeting the SH2 domain is a challenging task in molecular recognition, the progress reported here demonstrates the feasibility of such an approach.

Progress in the developing countries

International Nuclear Information System (INIS)

Simnad, M.

1981-01-01

Nuclear programmes in selective developing countries are briefly discussed. The oil rich countries of Iraq, Libya and Iran all have reactors on order. Turkey has decided to purchase a PWR from the USSR and Egypt's programme anticipates a capacity of 6600 MWe by 2000. The current projections for India are 6000 MWe by 1990 and 20,000 MWe by 2000. The progress of Pakistan, South Korea and other Asian countries are discussed. The predicted growth in reactors and population in Latin America is considered - 17 reactors presently planned for a population of 340 million and 18-57 possible additions in 2000 for an estimated population of 600 million. The role of the IAEA and experience of some Western countries in technology transfer is discussed with the ambitious Spanish nuclear power programme and the experience of Argentina in purchasing Candu reactors. (author)

SOURCE 1ST 2.0: development and beta testing

International Nuclear Information System (INIS)

Barber, D.H.; Iglesias, F.C.; Hoang, Y.; Dickson, L.W.; Dickson, R.S.; Richards, M.J.; Gibb, R.A.

1999-01-01

SOURCE 1ST 2.0 is the Industry Standard fission product release code that is being developed by Ontario Power Generation, New Brunswick Power, Hydro-Quebec, and Atomic Energy of Canada Ltd. This paper is a report on recent progress on requirement specification, code development, and module verification and validation activities. The theoretical basis for each model in the code is described in a module Software Theory Manual. The development of SOURCE IST 2.0 has required code design decisions about how to implement the software requirements. Development and module testing of the β1 release of SOURCE IST 2.0 (released in July 1999) have led to some interesting insights into fission product release modelling. The beta testing process has allowed code developers and analysts to refine the software requirements for the code. The need to verify physical reference data has guided some decisions on the code and data structure design. Examples of these design decisions are provided. Module testing, and verification and validation activities are discussed. These activities include code-targeted testing, stress testing, code inspection, comparison of code with requirements, and comparison of code results with independent algebraic, numerical, or semi-algebraic calculations. The list of isotopes to be modelled by SOURCE IST 2.0 provides an example of a subset of a reference data set. Isotopes are present on the list for a variety of reasons: personnel or public dose, equipment dose (for environmental qualification), fission rate and actinide modelling, or stable (or long-lived) targets for activation processes. To accommodate controlled changes to the isotope list, the isotope list and associated nuclear data are contained in a reference data file. The questions of multiple computing platforms, and of Year 2000 compliance have been addressed by programming rules for the code. By developing and testing modules on most of the different platforms on which the code is intended

Development and testing of prototype alpha waste incinerator off-gas systems

International Nuclear Information System (INIS)

Freed, E.J.; Becker, G.W.

1982-01-01

A test program is in progress at Savannah River Laboratory (SRL) to confirm and develop incinerator design technology for an SRP production Alpha Waste Incinerator (AWI) to be built in the mid-1980's. The Incinerator Components Test Facility (ICTF) is a full-scale (5 kg/h), electrically heated, controlled-air prototype incinerator built to burn nonradioactive solid waste. The incinerator has been operating successfully at SRL since March 1979 and has met or exceeded all design criteria. During the first 1-1/2 years of operation, liquid scrubbers were used to remove particulates and hydrochloric acid from the incinerator exhaust gases. A dry off-gas system is currently being tested to provide data to Savannah River Plant's proposed AWI

Review of progresses on clinical applications of ion selective electrodes for electrolytic ion tests: from conventional ISEs to graphene-based ISEs

Directory of Open Access Journals (Sweden)

Rongguo Yan

2016-10-01

Full Text Available There exist several positively and negatively charged electrolytes or ions in human blood, urine, and other body fluids. Tests that measure the concentration of these ions in clinics are performed using a more affordable, portable, and disposable potentiometric sensing method with few sample volumes, which requires the use of ion-selective electrodes (ISEs and reference electrodes. This review summarily descriptively presents progressive developments and applications of ion selective electrodes in medical laboratory electrolytic ion tests, from conventional ISEs, solid-contact ISEs, carbon nanotube based ISEs, to graphene-based ISEs.

IFMIF high flux test module - recent progress in design and manufacturing

International Nuclear Information System (INIS)

Leichtle, D.; Arbeiter, F.; Dolensky, B.

2007-01-01

The International Fusion Material Irradiation Facility (IFMIF) is an accelerator driven neutron source for irradiation tests of candidate fusion reactor materials. Two 40 MeV deuterium beams with 125 mA each strike a liquid lithium jet target, producing a high intensity neutron flux up to 55 MeV, which penetrates the adjacent test modules. Within the High Flux Test Module (HFTM) a testing volume of 0.5 litres filled by qualified small scale specimens will be irradiated at displacement rates of 20-50 dpa/fpy in structural materials. The HFTM will also provide helium and hydrogen production to dpa ratios that reflect within the uncertainties the values expected in a DEMO fusion reactor The Forschungszentrum Karlsruhe (FZK) has developed a HFTM design which closely follows the design premise of maximising the space available for irradiation specimens in the IFMIF high flux zone and in addition allows keeping the temperature nearly constant in the rigs containing the specimen. Within the entire specimen stack the temperature deviation will be below about 15 K. The main design principles applied are (i) filling the gaps between the specimens with liquid metal, (ii) winding three separately controlled heater sections on the inner capsules and (iii) dividing the test rigs in a hot inner and a cold outer zone, which a separated by a gap filled with stagnant helium that serves as a thermal insulator. Channels between the outer covers (the cold parts) are cooled by helium gas at moderate pressure (3 bars at inlet) and temperature (50 C). 12 identical rigs holding the specimen capsules which are heated by segmented helically wound electrical heaters ensure a flexible loading scheme during IFMIF operation. Complementary analyses on nuclear, thermo-hydraulics and mechanical performance of the HFTM were performed to optimize the design. The present paper highlights the main design characteristics as well as recent progress achieved in this area. This includes the stiffening of

FY2012 Progress Report for Energy Storage Research & Development

Energy Technology Data Exchange (ETDEWEB)

none,

2013-01-01

FY 2012 annual report of the energy storage research and development effort within the VT Office. An important step for the electrification of the nation’s light duty transportation sector is the development of more cost-effective, long lasting, and abuse-tolerant PEV batteries. In fiscal year 2012, battery R&D work continued to focus on the development of high-energy batteries for PEVs and very high power devices for hybrid vehicles. This document provides a summary and progress update of the VTP battery R&D projects that were supported in 2012.

Performance and Environmental Test Results of the High Voltage Hall Accelerator Engineering Development Unit

Science.gov (United States)

Kamhawi, Hani; Haag, Thomas; Huang, Wensheng; Shastry, Rohit; Pinero, Luis; Peterson, Todd; Mathers, Alex

2012-01-01

NASA Science Mission Directorate's In-Space Propulsion Technology Program is sponsoring the development of a 3.5 kW-class engineering development unit Hall thruster for implementation in NASA science and exploration missions. NASA Glenn and Aerojet are developing a high fidelity high voltage Hall accelerator that can achieve specific impulse magnitudes greater than 2,700 seconds and xenon throughput capability in excess of 300 kilograms. Performance, plume mappings, thermal characterization, and vibration tests of the high voltage Hall accelerator engineering development unit have been performed. Performance test results indicated that at 3.9 kW the thruster achieved a total thrust efficiency and specific impulse of 58%, and 2,700 sec, respectively. Thermal characterization tests indicated that the thruster component temperatures were within the prescribed material maximum operating temperature limits during full power thruster operation. Finally, thruster vibration tests indicated that the thruster survived the 3-axes qualification full-level random vibration test series. Pre and post-vibration test performance mappings indicated almost identical thruster performance. Finally, an update on the development progress of a power processing unit and a xenon feed system is provided.

'Alzheimer's Progression Score': Development of a Biomarker Summary Outcome for AD Prevention Trials.

Science.gov (United States)

Leoutsakos, J-M; Gross, A L; Jones, R N; Albert, M S; Breitner, J C S

2016-01-01

Alzheimer's disease (AD) prevention research requires methods for measurement of disease progression not yet revealed by symptoms. Preferably, such measurement should encompass multiple disease markers. Evaluate an item response theory (IRT) model-based latent variable Alzheimer Progression Score (APS) that uses multi-modal disease markers to estimate pre-clinical disease progression. Estimate APS scores in the BIOCARD observational study, and in the parallel PREVENT-AD Cohort and its sister INTREPAD placebo-controlled prevention trial. Use BIOCARD data to evaluate whether baseline and early APS trajectory predict later progression to MCI/dementia. Similarly, use longitudinal PREVENT-AD data to assess test measurement invariance over time. Further, assess portability of the PREVENT-AD IRT model to baseline INTREPAD data, and explore model changes when CSF markers are added or withdrawn. BIOCARD was established in 1995 and participants were followed up to 20 years in Baltimore, USA. The PREVENT-AD and INTREPAD trial cohorts were established between 2011-2015 in Montreal, Canada, using nearly identical entry criteria to enroll high-risk cognitively normal persons aged 60+ then followed for several years. 349 cognitively normal, primarily middle-aged participants in BIOCARD, 125 high-risk participants aged 60+ in PREVENT-AD, and 217 similar subjects in INTREPAD. 106 INTREPAD participants donated up to four serial CSF samples. Global cognitive assessment and multiple structural, functional, and diffusion MRI metrics, sensori-neural tests, and CSF concentrations of tau, Aβ42 and their ratio. Both baseline values and early slope of APS scores in BIOCARD predicted later progression to MCI or AD. Presence of CSF variables strongly improved such prediction. A similarly derived APS in PREVENT-AD showed measurement invariance over time and portability to the parallel INTREPAD sample. An IRT-based APS can summarize multimodal information to provide a longitudinal measure of

A process for developing and revising a learning progression on sea level rise using learners' explanations

Science.gov (United States)

McDonald, Robert Christopher

The purpose of this study was to explore the process of developing a learning progression (LP) on constructing explanations about sea level rise. I used a learning progressions theoretical framework informed by the situated cognition learning theory. During this exploration, I explicitly described my decision-making process as I developed and revised a hypothetical learning progression. Correspondingly, my research question was: What is a process by which a hypothetical learning progression on sea level rise is developed into an empirical learning progression using learners' explanations? To answer this question, I used a qualitative descriptive single case study with multiple embedded cases (Yin, 2014) that employed analytic induction (Denzin, 1970) to analyze data collected on middle school learners (grades 6-8). Data sources included written artifacts, classroom observations, and semi-structured interviews. Additionally, I kept a researcher journal to track my thinking about the learning progression throughout the research study. Using analytic induction to analyze collected data, I developed eight analytic concepts: participant explanation structures varied widely, global warming and ice melt cause sea level rise, participants held alternative conceptions about sea level rise, participants learned about thermal expansion as a fundamental aspect of sea level rise, participants learned to incorporate authentic scientific data, participants' mental models of the ocean varied widely, sea ice melt contributes to sea level rise, and participants held vague and alternative conceptions about how pollution impacts the ocean. I started with a hypothetical learning progression, gathered empirical data via various sources (especially semi-structured interviews), revised the hypothetical learning progression in response to those data, and ended with an empirical learning progression comprising six levels of learner thinking. As a result of developing an empirically based LP

Developing and testing an operational framework for assessing quality of life

International Nuclear Information System (INIS)

Fahy, F.; O Cinneide, M.

2008-01-01

Difficulties with operationalising the concept of sustainable development have generated much debate, and have stimulated a good deal of research on the challenging task of assessing progress towards that goal. This paper focuses on quality of life, as one discourse in the sustainable development literature, and reports on the development and testing of an operational framework for the assessment of quality of life in an urban setting. Core principles of sustainable development are translated into a set of operational criteria for investigating quality of life. The process of formulating these criteria and the manner in which they may be linked to policy and practice are outlined. The application of the framework is demonstrated by reference to the experience of implementing it in an urban centre in Ireland

Development and progress of the South African uranium enrichment project

International Nuclear Information System (INIS)

Roux, A.J.A.; Grant, W.L.; Barbour, R.A.; Loubser, R.S.; Wannenburg, J.J.

1977-01-01

The earlier development of the project is briefly reviewed, and some of the salient features of the South African process are touched upon. Development of the separation element in the last 18 months is discussed, as well as further work on the helikon cascade process. A brief description of the helikon cascade operation is given by means of diagrams. Because of time limitations, the complete helikon theory is not presented, but only some examples shown. Experimental work done to verify the helikon concept, as well as theoretical treatment, is presented. A brief report of the progress made on the experimental module of 6 t/a separative work capacity is given. This module, known as Mini-Z, is well advanced and details of its features and construction are shown. A short discussion of progress on the full-scale prototype module, known as Proto-Z, is next presented. The flexibility of such a design to fit a wide range of cascade sizes is considered, as well as cost implications of various approaches to design. Apart from progress on the development of the commercial plant, a brief review is given of the present state of the pilot plant at Valindaba. Some of the information obtained is mentioned. In conclusion, some information is given in regard to further planning and other work on the commercial plant at present being undertaken. Projected operation of the plant and some nuclear fuel service aspects are touched on

Chewability testing in the development of a chewable tablet for hyperphosphatemia.

Science.gov (United States)

Lanz, Michael; Baldischweiler, Jan; Kriwet, Burkhard; Schill, Jutta; Stafford, John; Imanidis, Georgios

2014-12-01

The official Pharmacopeia does not include a test procedure for the in vitro estimation of the chewability of tablets and publications in the scientific literature on this subject are rare. The purpose of this study was to evaluate a number of different test procedures for assessing chewability, starting from standard breaking force and strength testing and progressing to develop new procedures that simulate the actual chewing action on tablets. A further goal was to apply these test procedures to characterize the chewability of the novel phosphate binder PA21 in comparison with a commercially available phosphate binder chewable tablet product based on lanthanum (Fosrenol®) and a chewable tablet product containing calcium (Calcimagon®) - the latter being used as a standard for its very good chewability. For this purpose, a number of development formulations (different batches of PA21) were tested. The radial or diametrical tablet breaking force offers a poor means of assessing chewability while the axial breaking force was concluded to better reflect the effect of chewing on the tablet. Measurement of tablet behavior upon repeated loading afforded the best simulation of the actual chewing action and was found to have a good discriminating power with respect to chewability of the tested tablets, especially when the tablet was moistened with artificial saliva. The developed tests are shown to be more suitable for evaluating chewing properties of tablets than currently used Pharmacopeial tests. Following ICHQ6, which calls for specification of hardness for chewable tablets, these test procedures enabled the optimal chewability features of PA21 tablets in development to be confirmed whilst still maintaining capabilities for robust production and transportation processes.

Baseline Gas Turbine Development Program. Fourteenth quarterly progress report

Energy Technology Data Exchange (ETDEWEB)

Schmidt, F W; Wagner, C E

1976-04-30

Progress is reported for a Baseline Gas Turbine Development Program sponsored by the Heat Engine Systems Branch, Division of Transportation Energy Conservation (TEC) of the Energy Research and Development Administration (ERDA). Structurally, this program is made up of three parts: (1) documentation of the existing automotive gas turbine state-of-the-art; (2) conduction of an extensive component improvement program; and (3) utilization of the improvements in the design, and building of an Upgraded Engine capable of demonstrating program goals.

Progress in Brucella vaccine development

Science.gov (United States)

YANG, Xinghong; SKYBERG, Jerod A.; CAO, Ling; CLAPP, Beata; THORNBURG, Theresa; PASCUAL, David W.

2012-01-01

Brucella spp. are zoonotic, facultative intracellular pathogens, which cause animal and human disease. Animal disease results in abortion of fetuses; in humans, it manifests flu-like symptoms with an undulant fever, with osteoarthritis as a common complication of infection. Antibiotic regimens for human brucellosis patients may last several months and are not always completely effective. While there are no vaccines for humans, several licensed live Brucella vaccines are available for use in livestock. The performance of these animal vaccines is dependent upon the host species, dose, and route of immunization. Newly engineered live vaccines, lacking well-defined virulence factors, retain low residual virulence, are highly protective, and may someday replace currently used animal vaccines. These also have possible human applications. Moreover, due to their enhanced safety and efficacy in animal models, subunit vaccines for brucellosis show great promise for their application in livestock and humans. This review summarizes the progress of brucellosis vaccine development and presents an overview of candidate vaccines. PMID:23730309

Progress report on fast breeder reactor development in Japan

International Nuclear Information System (INIS)

1979-01-01

The experimental fast reactor ''Joyo'' will be tested at 75 MW output, starting in April, 1980. In connection with the accident in the Three Mile Island plant, the reexamination of the plant safety and the rechecking-up of the maintenance control system were carried out, and the special inspection by the Science and Technology Agency was executed from May 21 to 23, 1979. Thereafter, the preparation for raising the power output was completed. The periodical inspection after the completion of 50 MW operation is being carried out. The state of progress of various equipments and the codes for core characteristic analysis is reported. The construction preliminary design (2) of the prototype reactor ''Monju'' is examined, and the same design (3) is prepared. The analysis of the decay heat in the prototype reactor is carried on for the safety licensing. The technological investigation of LMFBRs in foreign countries is under way. The preliminary design (4) of the demonstration reactor is under examination, and the technical specifications of the conceptual design (1) are prepared. The researches and developments of reactor physics, structural components, instrumentation and control, sodium technology, fuel materials, structures and materials, safety and steam generators are reported. (Kako, I.)

Development and field testing of a smartphone "App" for tinnitus management.

Science.gov (United States)

Henry, James A; Thielman, Emily; Zaugg, Tara; Kaelin, Christine; Choma, Christie; Chang, Bill; Hahn, Shira; Fuller, Bret

2017-10-01

This study's objective was to develop and test a smartphone app that supports learning and using coping skills for managing tinnitus. The app's content was based on coping skills that are taught as a part of progressive tinnitus management (PTM). The study involved three phases: (1) develop a prototype app and conduct usability testing; (2) conduct two focus groups to obtain initial feedback from individuals representing potential users; and (3) conduct a field study to evaluate the app, with three successive groups of participants. Participants were adults with bothersome tinnitus. For Phase 2, two focus groups were attended by a total of 17 participants. Phase 3 involved three consecutive rounds of participants: five from the focus groups followed by two rounds with 10 participants each who had not seen the app previously. In both the focus groups and field studies, participants responded favourably to the content. Certain features, however, were deemed too complex. Completion of this project resulted in the development and testing of the delivery of PTM coping skills via a smartphone app. This new approach has the potential to improve access to coping skills for those with bothersome tinnitus.

Los Alamos Scientific Laboratory waste management technology development activities. Summary progress report, 1979

International Nuclear Information System (INIS)

Johnson, L.J.

1980-10-01

Summary reports on the Department of Energy's Nuclear Energy-sponsored waste management technology development projects at the Los Alamos Scientific Laboratory describe progress for calendar year 1979. Activities in airborne, low-level, and transuranic waste management areas are discussed. Work progress on waste assay, treatment, disposal, and environmental monitoring is reviewed

The RERTR [Reduced Enrichment Research and Test Reactor] program: A progress report

International Nuclear Information System (INIS)

Travelli, A.

1986-11-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1985, the activities, results, and new developments which occurred in 1986 are reviewed. The second miniplate series, concentrating on U 3 Si 2 -Al and U 3 Si-Al fuels, was expanded and its irradiation continued. Postirradiation examinations of several of these miniplates and of six previously irradiated U 3 Si 2 -Al full-size elements were completed with excellent results. The whole-core ORR demonstration with U 3 Si 2 -Al fuel at 4.8 g U/cm 3 is well under way and due for completion before the end of 1987. DOE removed an important barrier to conversions by announcing that the new LEU fuels will be accepted for reprocessing. New DOE prices for enrichment and reprocessing services were calculated to have minimal effect on HEU reactors, and to reduce by about 8 to 10% the total fuel cycle costs of LEU reactors. New program activities include preliminary feasibility studies of LEU use in DOE reactors, evaluation of the feasibility to use LEU targets for the production of fission-product 99 Mo, and responsibility for coordinating safety evaluations related to LEU conversions of US university reactors, as required by NRC. Achievement of the final program goals is projected for 1990. This progress could not have been achieved without close international cooperation, whose continuation and intensification are essential to the achievement of the ultimate goals of the RERTR Program

Creating a test blueprint for a progress testing program: A paired-comparisons approach.

Science.gov (United States)

von Bergmann, HsingChi; Childs, Ruth A

2018-03-01

Creating a new testing program requires the development of a test blueprint that will determine how the items on each test form are distributed across possible content areas and practice domains. To achieve validity, categories of a blueprint are typically based on the judgments of content experts. How experts judgments are elicited and combined is important to the quality of resulting test blueprints. Content experts in dentistry participated in a day-long faculty-wide workshop to discuss, refine, and confirm the categories and their relative weights. After reaching agreement on categories and their definitions, experts judged the relative importance between category pairs, registering their judgments anonymously using iClicker, an audience response system. Judgments were combined in two ways: a simple calculation that could be performed during the workshop and a multidimensional scaling of the judgments performed later. Content experts were able to produce a set of relative weights using this approach. The multidimensional scaling yielded a three-dimensional model with the potential to provide deeper insights into the basis of the experts' judgments. The approach developed and demonstrated in this study can be applied across academic disciplines to elicit and combine content experts judgments for the development of test blueprints.

What are the factors that affect band 5 nurses' career development and progression?

Science.gov (United States)

Balls, Paula

Continuing professional development (CPD) and career progression opportunities have been linked with job satisfaction and intent to remain in nursing. To provide an insight into band 5 registered nurses' perceptions of development opportunities and their ability to change posts. A hermeneutic phenomenological approach was used, collecting data through semi structured interviews with six RNs. Seven themes emerged, including the thirst for knowledge and the importance of structured learning and career advice. Barriers to career development were perceived as the working environment and the trust not enabling and facilitating development through funding and release time. Ward and team culture can inhibit career development and progression by failing to nurture staff and promote self confidence. In addition, organisational changes can facilitate career mobility.

Los Alamos Scientific Laboratory waste management technology development activities. Summary progress report, 1979

Energy Technology Data Exchange (ETDEWEB)

Johnson, L.J. (comp.)

1980-10-01

Summary reports on the Department of Energy's Nuclear Energy-sponsored waste management technology development projects at the Los Alamos Scientific Laboratory describe progress for calendar year 1979. Activities in airborne, low-level, and transuranic waste management areas are discussed. Work progress on waste assay, treatment, disposal, and environmental monitoring is reviewed.

Progressive Modularization: Reframing Our Understanding of Typical and Atypical Language Development

Science.gov (United States)

D'Souza, Dean; Filippi, Roberto

2017-01-01

The ability to acquire language is a critical part of human development. Yet there is no consensus on how the skill emerges in early development. Does it constitute an innately-specified, language-processing module or is it acquired progressively? One of Annette Karmiloff-Smith's (1938-2016) key contributions to developmental science addresses…

Progress in Developing a New 5 Kilowatt Free-Piston Stirling Space Convertor

International Nuclear Information System (INIS)

Brandhorst, Henry W. Jr.; Kirby, Raymond L.; Chapman, Peter A.

2008-01-01

The NASA Vision for Exploration of the Moon envisions a nuclear reactor coupled with a free-piston Stirling convertor at a power level of 30-40 kWe. In the 1990s, Mechanical Technology, Inc.'s Stirling Engine Systems Division (now a part of Foster-Miller, Inc.) developed a 25 kWe free piston Stirling Space Power Demonstrator Engine under the SP-100 program. This system consisted of two 12.5 kWe engines connected at their hot ends and mounted in tandem to cancel vibration. Recently, NASA and DoE have been developing dual 55 We and 80 We Stirling convertor systems for use with radioisotope heat sources. Total test times of all convertors in this effort exceed 120,000 hours. Recently, NASA began a new project with Auburn University to develop a 5 kWe, single convertor for use in the Lunar power system. Goals of this development program include a specific power in excess of 140 We/kg at the convertor level, lifetime in excess of five years and a control system that will safely manage the convertors in case of an emergency. Auburn University awarded a subcontract to Foster-Miller, Inc. to undertake development of the 5 kWe Stirling Convertor Assembly. The characteristics of the design along with progress in developing the system will be described

Progress in Developing a New 5 Kilowatt Free-Piston Stirling Space Convertor

Science.gov (United States)

Brandhorst, Henry W.; Kirby, Raymond L.; Chapman, Peter A.

2008-01-01

The NASA Vision for Exploration of the Moon envisions a nuclear reactor coupled with a free-piston Stirling convertor at a power level of 30-40 kWe. In the 1990s, Mechanical Technology, Inc.'s Stirling Engine Systems Division (now a part of Foster-Miller, Inc.) developed a 25 kWe free piston Stirling Space Power Demonstrator Engine under the SP-100 program. This system consisted of two 12.5 kWe engines connected at their hot ends and mounted in tandem to cancel vibration. Recently, NASA and DoE have been developing dual 55 We and 80 We Stirling convertor systems for use with radioisotope heat sources. Total test times of all convertors in this effort exceed 120,000 hours. Recently, NASA began a new project with Auburn University to develop a 5 kWe, single convertor for use in the Lunar power system. Goals of this development program include a specific power in excess of 140 We/kg at the convertor level, lifetime in excess of five years and a control system that will safely manage the convertors in case of an emergency. Auburn University awarded a subcontract to Foster-Miller, Inc. to undertake development of the 5 kWe Stirling Convertor Assembly. The characteristics of the design along with progress in developing the system will be described.

Taking stock of Myanmar's progress toward the health-related Millennium Development Goals: current roadblocks, paths ahead.

Science.gov (United States)

Saw, Yu Mon; Win, Khine Lae; Shiao, Laura Wen-Shuan; Thandar, Moe Moe; Amiya, Rachel M; Shibanuma, Akira; Tun, Soe; Jimba, Masamine

2013-09-11

Myanmar is a developing country with considerable humanitarian needs, rendering its pursuit of the Millennium Development Goals (MDGs) an especially high priority. Yet progress to date remains under-examined on key fronts. Particularly within the three health-related MDGs (MDGs 4, 5, and 6), the limited data reported point to patchy levels of achievement. This study was undertaken to provide an overview and assessment of Myanmar's progress toward the health-related MDGs, along with possible solutions for accelerating health-related development into 2015 and beyond. The review highlights off-track progress in the spheres of maternal and child health (MDGs 4 and 5). It also shows Myanmar's achievements toward MDG 6 targets--in the areas of HIV/AIDS, malaria, and tuberculosis. Such achievements are especially notable in that Myanmar has been receiving the lowest level of official development assistance among all of the least developed countries in Asia. However, to make similar progress in MDGs 4 and 5, Myanmar needs increased investment and commitment in health. Toward moving forward with the post-2015 development agenda, Myanmar's government also needs to take the lead in calling for attention from the World Health Organization and its global development partners to address the stagnation in health-related development progress within the country. In particular, Myanmar's government should invest greater efforts into health system strengthening to pave the road to universal health coverage.

Advanced Turbine Systems (ATS) program conceptual design and product development. Quarterly progress report, December 1, 1995--February 29, 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-06-01

This report describes the overall program status of the General Electric Advanced Gas Turbine Development program, and reports progress on three main task areas. The program is focused on two specific products: (1) a 70-MW class industrial gas turbine based on the GE90 core technology, utilizing a new air cooling methodology; and (2) a 200-MW class utility gas turbine based on an advanced GE heavy-duty machine, utilizing advanced cooling and enhancement in component efficiency. The emphasis for the industrial system is placed on cycle design and low emission combustion. For the utility system, the focus is on developing a technology base for advanced turbine cooling while achieving low emission combustion. The three tasks included in this progress report are on: conversion to a coal-fueled advanced turbine system, integrated program plan, and design and test of critical components. 13 figs., 1 tab.

Semiannual progress report for the Idaho Geothermal Program, April 1-September 30, 1981

Energy Technology Data Exchange (ETDEWEB)

Parker, J.T. (ed.)

1982-01-01

Modifications incorporated in the 5-MW Pilot Power Plant at Raft River Geothermal Test Site, system operational testing and maintenance activities at that plant, and the water treatment program's corrosion studies are summarized. Progress is reported on performance tests of the ORNL condenser and the direct-contact heat exchanger in the Prototype Power Plant. Production-injection tests associated with pump installation in monitor wells at Raft River are reported. Case studies conducted and publications prepared for the program of low-to moderate-temperature hydrothermal resource development are also reported. Monitoring activities and studies of the environmental program at Raft River are described and two new areas of research under the Environmental Support Injection Research Program: pressure monitoring, and dispersion studies. Progress of three successful proposers under the User-Coupled Confirmation Drilling Program is summarized. A program to encourage use of geothermal energy at Federal facilities was developed and initiated. Investigation of direct use of hydrothermal energy is reported. Progress is reported on the marketing Assistance Program, through which technical information and assistance are provided to potential users and developers of geothermal resources. Also reported is progress on DOE's Program Opportunity Notice (PON) Program demonstration projects and the Program Research and Development Announcement (PRDA) Program study projects.

Diagnostic development and support of MHD test facilities: Technical progress report for the period January, February, March 1985

International Nuclear Information System (INIS)

Shepard, W.S.; Cook, R.L.

1985-04-01

Mississippi State University is developing diagnostic instruments for MHD power train data acquisition and for support of MHD component development test facilities. Microprocessor-controlled optical instruments, initially developed for HRSR support, are being refined, and new systems to measure temperatures and gas-seed-slag stream characteristics are being developed. To further data acquisition and analysis capabilities, the diagnostic systems are being interfaced with MHD Energy Center computers. Additionally, technical support of the diagnostic needs of the national MHD research effort is being provided

Progress towards extreme attitude testing with Magnetic Suspension and Balance Systems

Science.gov (United States)

Britcher, Colin P.; Parker, David H.

1988-01-01

Progress is reported in a research effort aimed towards demonstration of the feasibility of suspension and aerodynamic testing of models at high angles of attack in wind tunnel Magnetic Suspension and Balance Systems. Extensive modifications, described in this paper, have been made to the Southampton University suspension system in order to facilitate this work. They include revision of electromagnet configuration, installation of all-new position sensors and expansion of control system programs. An angle of attack range of 0 to 90 deg is expected for axisymmetric models. To date, suspension up to 80 deg angle of attack has been achieved.

Progress on standardization and automation in software development on W7X

International Nuclear Information System (INIS)

Kühner, Georg; Bluhm, Torsten; Heimann, Peter; Hennig, Christine; Kroiss, Hugo; Krom, Jon; Laqua, Heike; Lewerentz, Marc; Maier, Josef; Schacht, Jörg; Spring, Anett; Werner, Andreas; Zilker, Manfred

2012-01-01

Highlights: ► For W7X software development the use of ISO/IEC15504-5 is further extended. ► The standard provides a basis to manage software multi-projects for a large system project. ► Adoption of a scrum-like management allows for quick reaction on priority changes. ► A high degree of software build automation allows for quick responses to user requests. ► It provides additional resources to concentrate work on product quality (ISO/IEC 25000). - Abstract: For a complex experiment like W7X being subject to changes all along its projected lifetime the advantages of a formalized software development method have already been stated. Quality standards like ISO/IEC-12207 provide a guideline for structuring of development work and improving process and product quality. A considerable number of tools has emerged supporting and automating parts of development work. On W7X progress has been made during the last years in exploiting the benefit of automation and management during software development: –Continuous build, integration and automated test of software artefacts. ∘Syntax checks and code quality metrics. ∘Documentation generation. ∘Feedback for developers by temporal statistics. –Versioned repository for build products (libraries, executables). –Separate snapshot and release repositories and automatic deployment. –Semi-automatic provisioning of applications. –Feedback from testers and feature requests by ticket system. This toolset is working efficiently and allows the team to concentrate on development. The activity there is presently focused on increasing the quality of the existing software to become a dependable product. Testing of single functions and qualities must be simplified. So a restructuring is underway which relies more on small, individually testable components with standardized interfaces providing the capability to construct arbitrary function aggregates for dedicated tests of quality attributes as availability, reliability

Progress on standardization and automation in software development on W7X

Energy Technology Data Exchange (ETDEWEB)

Kuehner, Georg, E-mail: kuehner@ipp.mpg.de [Max-Planck-Institut fuer Plasmaphysik, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Bluhm, Torsten [Max-Planck-Institut fuer Plasmaphysik, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Heimann, Peter [Max-Planck-Institut fuer Plasmaphysik, Boltzmannstrasse 2, D-85748 Garching (Germany); Hennig, Christine [Max-Planck-Institut fuer Plasmaphysik, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Kroiss, Hugo [Max-Planck-Institut fuer Plasmaphysik, Boltzmannstrasse 2, D-85748 Garching (Germany); Krom, Jon; Laqua, Heike; Lewerentz, Marc [Max-Planck-Institut fuer Plasmaphysik, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Maier, Josef [Max-Planck-Institut fuer Plasmaphysik, Boltzmannstrasse 2, D-85748 Garching (Germany); Schacht, Joerg; Spring, Anett; Werner, Andreas [Max-Planck-Institut fuer Plasmaphysik, Wendelsteinstrasse 1, D-17491 Greifswald (Germany); Zilker, Manfred [Max-Planck-Institut fuer Plasmaphysik, Boltzmannstrasse 2, D-85748 Garching (Germany)

2012-12-15

Highlights: Black-Right-Pointing-Pointer For W7X software development the use of ISO/IEC15504-5 is further extended. Black-Right-Pointing-Pointer The standard provides a basis to manage software multi-projects for a large system project. Black-Right-Pointing-Pointer Adoption of a scrum-like management allows for quick reaction on priority changes. Black-Right-Pointing-Pointer A high degree of software build automation allows for quick responses to user requests. Black-Right-Pointing-Pointer It provides additional resources to concentrate work on product quality (ISO/IEC 25000). - Abstract: For a complex experiment like W7X being subject to changes all along its projected lifetime the advantages of a formalized software development method have already been stated. Quality standards like ISO/IEC-12207 provide a guideline for structuring of development work and improving process and product quality. A considerable number of tools has emerged supporting and automating parts of development work. On W7X progress has been made during the last years in exploiting the benefit of automation and management during software development: -Continuous build, integration and automated test of software artefacts. Ring-Operator Syntax checks and code quality metrics. Ring-Operator Documentation generation. Ring-Operator Feedback for developers by temporal statistics. -Versioned repository for build products (libraries, executables). -Separate snapshot and release repositories and automatic deployment. -Semi-automatic provisioning of applications. -Feedback from testers and feature requests by ticket system. This toolset is working efficiently and allows the team to concentrate on development. The activity there is presently focused on increasing the quality of the existing software to become a dependable product. Testing of single functions and qualities must be simplified. So a restructuring is underway which relies more on small, individually testable components with standardized

Stromal Androgen Receptor in Prostate Cancer Development and Progression

Science.gov (United States)

Leach, Damien A.; Buchanan, Grant

2017-01-01

Prostate cancer development and progression is the result of complex interactions between epithelia cells and fibroblasts/myofibroblasts, in a series of dynamic process amenable to regulation by hormones. Whilst androgen action through the androgen receptor (AR) is a well-established component of prostate cancer biology, it has been becoming increasingly apparent that changes in AR signalling in the surrounding stroma can dramatically influence tumour cell behavior. This is reflected in the consistent finding of a strong association between stromal AR expression and patient outcomes. In this review, we explore the relationship between AR signalling in fibroblasts/myofibroblasts and prostate cancer cells in the primary site, and detail the known functions, actions, and mechanisms of fibroblast AR signaling. We conclude with an evidence-based summary of how androgen action in stroma dramatically influences disease progression. PMID:28117763

Large shaft development test plan

International Nuclear Information System (INIS)

Krug, A.D.

1984-03-01

This test plan proposes the conduct of shaft liner tests as part of the large shaft development test proposed for the Hanford Site in support of the repository development program. The objectives of these tests are to develop techniques for measuring liner alignment (straightness), both construction assembly alignment and downhole cumulative alignment, and to assess the alignment information as a real time feedback to aid the installation procedure. The test plan is based upon installing a 16 foot ID shaft liner into a 20 foot diameter shaft to a depth of 1000 feet. This test plan is considered to be preliminary in that it was prepared as input for the decision to determine if development testing is required in this area. Should the decision be made to proceed with development testing, this test plan shall be updated and revised. 6 refs., 2 figs

Current developments in mechanized non-destructive testing in nuclear power plants

International Nuclear Information System (INIS)

Zeilinger, R.

2008-01-01

Nuclear power plants require frequent in-service activities to be carried out conscientiously in areas potentially hazardous to human operators (because of the associated radiation exposure), such as non-destructive testing of pressurized components of the steam system. Locations to be inspected in this way include the reactor pressure vessel, core internals, steam generators, pressurizers, and pipes. The codes to be used as a basis of these inspections demand high absolute positioning and repeating accuracy. These requirements can be met by mechanized test procedures. Accordingly, many new applications of, mostly mobile, robots have been developed over the past few years. The innovative control and sensor systems for stationary and mobile robots now on the market offer a potential for economic application in a large number of new areas in inspection, maintenance and service in nuclear power plants. More progress in this area is expected for the near future. Areva NP founded the new NDT Center, NETEC (Non-destructive Examination Technical Center), as a global technical center for non-destructive materials testing. NETEC is to advance research and development of all basic NDT technologies, robotics included. For many years, intelligeNDT has offered solutions and products for a variety of inspection and testing purposes and locations in nuclear power plants and is involved in continuous further development of the experience collected in nuclear power plants on the spot. (orig.)

Progress in quantitative GPR development at CNDE

Science.gov (United States)

Eisenmann, David; Margetan, F. J.; Chiou, C.-P.; Roberts, Ron; Wendt, Scott

2014-02-01

Ground penetrating radar (GPR) uses electromagnetic (EM) radiation pulses to locate and map embedded objects. Commercial GPR instruments are generally geared toward producing images showing the location and extent of buried objects, and often do not make full use of available absolute amplitude information. At the Center for Nondestructive Evaluation (CNDE) at Iowa State University efforts are underway to develop a more quantitative approach to GPR inspections in which absolute amplitudes and spectra of measured signals play a key role. Guided by analogous work in ultrasonic inspection, there are three main thrusts to the effort. These focus, respectively, on the development of tools for: (1) analyzing raw GPR data; (2) measuring the EM properties of soils and other embedding media; and (3) simulating GPR inspections. This paper reviews progress in each category. The ultimate goal of the work is to develop model-based simulation tools that can be used assess the usefulness of GPR for a given inspection scenario, to optimize inspection choices, and to determine inspection reliability.

Progress in quantitative GPR development at CNDE

International Nuclear Information System (INIS)

Eisenmann, David; Margetan, F. J.; Chiou, C.-P.; Roberts, Ron; Wendt, Scott

2014-01-01

Ground penetrating radar (GPR) uses electromagnetic (EM) radiation pulses to locate and map embedded objects. Commercial GPR instruments are generally geared toward producing images showing the location and extent of buried objects, and often do not make full use of available absolute amplitude information. At the Center for Nondestructive Evaluation (CNDE) at Iowa State University efforts are underway to develop a more quantitative approach to GPR inspections in which absolute amplitudes and spectra of measured signals play a key role. Guided by analogous work in ultrasonic inspection, there are three main thrusts to the effort. These focus, respectively, on the development of tools for: (1) analyzing raw GPR data; (2) measuring the EM properties of soils and other embedding media; and (3) simulating GPR inspections. This paper reviews progress in each category. The ultimate goal of the work is to develop model-based simulation tools that can be used assess the usefulness of GPR for a given inspection scenario, to optimize inspection choices, and to determine inspection reliability

Progress in quantitative GPR development at CNDE

Energy Technology Data Exchange (ETDEWEB)

Eisenmann, David; Margetan, F. J.; Chiou, C.-P.; Roberts, Ron; Wendt, Scott [Center for Nondestructive Evaluation, Iowa State University, 1915 Scholl Road, Ames, IA 50011-3042 (United States)

2014-02-18

Ground penetrating radar (GPR) uses electromagnetic (EM) radiation pulses to locate and map embedded objects. Commercial GPR instruments are generally geared toward producing images showing the location and extent of buried objects, and often do not make full use of available absolute amplitude information. At the Center for Nondestructive Evaluation (CNDE) at Iowa State University efforts are underway to develop a more quantitative approach to GPR inspections in which absolute amplitudes and spectra of measured signals play a key role. Guided by analogous work in ultrasonic inspection, there are three main thrusts to the effort. These focus, respectively, on the development of tools for: (1) analyzing raw GPR data; (2) measuring the EM properties of soils and other embedding media; and (3) simulating GPR inspections. This paper reviews progress in each category. The ultimate goal of the work is to develop model-based simulation tools that can be used assess the usefulness of GPR for a given inspection scenario, to optimize inspection choices, and to determine inspection reliability.

Next generation of procedural skills curriculum development: Proficiency-based progression

Directory of Open Access Journals (Sweden)

Richard M. Satava

2015-01-01

Conclusion: The FRS use a new process (full life-cycle curriculum development with proficiency-based progression which can be used in order to develop any quantitative procedural curriculum, through generic templates that have been developed. Such an approach will dramatically decrease the cost, time and effort to develop a new specific curriculum, while producing uniformity in approach, inter-operability among different curricula and consistency in objective assessment. This process is currently online, open source and freely available, to encourage the adoption of a scholarly and rigorous approach to curriculum development which is flexible enough to be adopted and adapted to most technical skills curriculum needs.

High temperature turbine technology program. Phase II. Technology test and support studies. Annual technical progress report, January 1, 1979-December 31, 1979

Energy Technology Data Exchange (ETDEWEB)

1980-01-01

Work performed on the High Temperature Turbine Technology Program, Phase II - Technology Test and Support Studies during the period from January 1, 1979 through December 31, 1979 is summarized. Objectives of the program elements as well as technical progress and problems encountered during this Phase II annual reporting period are presented. Progress on design, fabrication and checkout of test facilities and test rigs is described. LP turbine cascade tests were concluded. 350 hours of testing were conducted on the LP rig engine first with clean distillate fuel and then with fly ash particulates injected into the hot gas stream. Design and fabrication of the turbine spool technology rig components are described. TSTR 60/sup 0/ sector combustor rig fabrication and testing are reviewed. Progress in the design and fabrication of TSTR cascade rig components for operation on both distillate fuel and low Btu gas is described. The new coal-derived gaseous fuel synthesizing facility is reviewed. Results and future plans for the supporting metallurgical programs are discussed.

Progressive development of a digital cadastral data base

OpenAIRE

Thompson, R.J.

2013-01-01

A Digital Cadastral Data Base (DCDB) is a big investment for a jurisdiction tasked with the administration of land boundaries. In the past, the development of such a database produced no real pay-back on investment until many years, and millions of dollars had been committed. The Land Administration Domain Model (LADM) (ISO-TC211 2012) provides a model of a schema in which a progressive creation and improvement of a DCDB is possible, to allow benefits to be obtained even in the early stages o...

Tandem mirror experiment-upgrade neutral beam test stand: a powerful tool for development and quality assurance

International Nuclear Information System (INIS)

Hibbs, S.M.; Kane, R.J.; Kerr, R.G.; Poulsen, P.

1983-01-01

During construction of the Tandem Mirror Experiment-Upgrade (TMX-U), we assembled a test stand to develop electronics for the neutral beam system. In the first six months of test stand use we operated a few neutral beam injector modules and directed considerable effort toward improving the electronic system. As system development progressed, our focus turned toward improving the injector modules themselves. The test stand has proved to be the largest single contributor to the successful operation of neutral beams on TMX-U, primarily because it provides quality assurance andd development capability in conjunction with the scheduled activities of the main experiment. This support falls into five major categories: (1) electronics development, (2) operator training, (3) injector module testing and characterization, (4) injector module improvements, and (5) physics improvements (through areas affected by injector operation). Normal day-to-day operation of the test stand comes under the third category, testing and characterization, and comprises our final quality assurance activity for newly assembled or repaired modules before they are installed on TMX-U

Materials testing and requirements for the ERDA nuclear-powered artificial heart. Technical progress report, July 15, 1974--May 1, 1975

International Nuclear Information System (INIS)

Andrade, J.D.; Coleman, D.L.; Leigh, A.; Hufferd, W.L.

1975-01-01

Progress on the materials research and development effort for the ERDA-sponsored nuclear-powered artificial heart program is presented. Progress made during the first three years on hydrogel grafting and biological studies is summarized. Progress during the fourth year on studies of implanted artificial hearts, development of albumin surfaces, and in vitro mechanical studies is presented. (U.S.)

Fidelity of test development process within a national science grant

Science.gov (United States)

Brumfield, Teresa E.

In 2002, a math-science partnership (MSP) program was initiated by a national science grant. The purpose of the MSP program was to promote the development, implementation, and sustainability of promising partnerships among institutions of higher education, K-12 schools and school systems, as well as other important stakeholders. One of the funded projects included a teacher-scientist collaborative that instituted a professional development system to prepare teachers to use inquiry-based instructional modules. The MSP program mandated evaluations of its funded projects. One of the teacher-scientist collaborative project's outcomes specifically focused on teacher and student science content and process skills. In order to provide annual evidence of progress and to measure the impact of the project's efforts, and because no appropriate science tests were available to measure improvements in content knowledge of participating teachers and their students, the project contracted for the development of science tests. This dissertation focused on the process of test development within an evaluation and examined planned (i.e., expected) and actual (i.e., observed) test development, specifically concentrating on the factors that affected the actual test development process. Planned test development was defined as the process of creating tests according to the well-established test development procedures recommended by the AERA/APA/NCME 1999 Standards for Educational and Psychological Testing. Actual test development was defined as the process of creating tests as it actually took place. Because case study provides an in-depth, longitudinal examination of an event (i.e., case) in a naturalistic setting, it was selected as the appropriate methodology to examine the difference between planned and actual test development. The case (or unit of analysis) was the test development task, a task that was bounded by the context in which it occurred---and over which this researcher had

A learning progression based teaching module on the causes of seasons

International Nuclear Information System (INIS)

Galano, S.

2016-01-01

In this paper, we report about designing and validating a teaching learning module based on a learning progression and focused on the causes of seasons. An initial learning progression about the Celestial Motion big idea —causes of seasons, lunar and solar eclipse and Moon phases— was developed and validated. Existing curricula, research studies on alternative conceptions about these phenomena, and students’ answers to an open questionnaire were the starting point to develop initial learning progressions; then, a two-tier multiple-choice questionnaire was designed to validate and improve it. The questionnaire was submitted to about 300 secondary-school students whose answers were used to revise the hypothesized learning progressions. This improved version of the learning progression was used to design a module focused on the causes of seasons in which students were engaged in quantitative measurements with a photovoltaic panel to explain changes of the Sun rays’ flow on the Earth’s surface over the year. The efficacy of our module in improving students’ understanding of the phenomenon of the seasons was tested using our questionnaire as pre- and post-test.

Initial progress in the first wall, blanket, and shield Engineering Test Program for magnetically confined fusion-power reactors

International Nuclear Information System (INIS)

Herman, H.; Baker, C.C.; Maroni, V.A.

1981-10-01

The first wall/blanket/shield (FW/B/S) Engineering Test Program (ETP) progressed from the planning stage into implementation during July, 1981. The program, generic in nature, comprises four Test Program Elements (TPE's), the emphasis of which is on defining the performance parameters for the Fusion Engineering Device (FED) and the major fusion device to follow FED. These elements are: (1) nonnuclear thermal-hydraulic and thermomechanical testing of first wall and component facsimiles with emphasis on surface heat loads and heat transient (i.e., plasma disruption) effects; (2) nonnuclear and nuclear testing of FW/B/S components and assemblies with emphasis on bulk (nuclear) heating effects, integrated FW/B/S hydraulics and mechanics, blanket coolant system transients, and nuclear benchmarks; (3) FW/B/S electromagnetic and eddy current effects testing, including pulsed field penetration, torque and force restraint, electromagnetic materials, liquid metal MHD effects and the like; and (4) FW/B/S Assembly, Maintenance and Repair (AMR) studies focusing on generic AMR criteria, with the objective of preparing an AMR designers guidebook; also, development of rapid remote assembly/disassembly joint system technology, leak detection and remote handling methods

[Research progress and development trend of quantitative assessment techniques for urban thermal environment.

Science.gov (United States)

Sun, Tie Gang; Xiao, Rong Bo; Cai, Yun Nan; Wang, Yao Wu; Wu, Chang Guang

2016-08-01

Quantitative assessment of urban thermal environment has become a focus for urban climate and environmental science since the concept of urban heat island has been proposed. With the continual development of space information and computer simulation technology, substantial progresses have been made on quantitative assessment techniques and methods of urban thermal environment. The quantitative assessment techniques have been developed to dynamics simulation and forecast of thermal environment at various scales based on statistical analysis of thermal environment on urban-scale using the historical data of weather stations. This study reviewed the development progress of ground meteorological observation, thermal infrared remote sensing and numerical simulation. Moreover, the potential advantages and disadvantages, applicability and the development trends of these techniques were also summarized, aiming to add fundamental knowledge of understanding the urban thermal environment assessment and optimization.

Launch Control System Software Development System Automation Testing

Science.gov (United States)

Hwang, Andrew

2017-01-01

) tool to Brandon Echols, a fellow intern, and I. The purpose of the OCR tool is to analyze an image and find the coordinates of any group of text. Some issues that arose while installing the OCR tool included the absence of certain libraries needed to train the tool and an outdated software version. We eventually resolved the issues and successfully installed the OCR tool. Training the tool required many images and different fonts and sizes, but in the end the tool learned to accurately decipher the text in the images and their coordinates. The OCR tool produced a file that contained significant metadata for each section of text, but only the text and coordinates of the text was required for our purpose. The team made a script to parse the information we wanted from the OCR file to a different file that would be used by automation functions within the automated framework. Since a majority of development and testing for the automated test cases for the GUI in question has been done using live simulated data on the workstations at the Launch Control Center (LCC), a large amount of progress has been made. As of this writing, about 60% of all of automated testing has been implemented. Additionally, the OCR tool will help make our automated tests more robust due to the tool's text recognition being highly scalable to different text fonts and text sizes. Soon we will have the whole test system automated, allowing for more full-time engineers working on development projects.

Test-driven development with Mockito

CERN Document Server

Acharya, Sujoy

2013-01-01

This book is a hands-on guide, full of practical examples to illustrate the concepts of Test Driven Development.If you are a developer who wants to develop software following Test Driven Development using Mockito and leveraging various Mockito features, this book is ideal for you. You don't need prior knowledge of TDD, Mockito, or JUnit.It is ideal for developers, who have some experience in Java application development as well as a basic knowledge of unit testing, but it covers the basic fundamentals of TDD and JUnit testing to get you acquainted with these concepts before delving into them.

Oxidative stress: development and progression of breast cancer:review article

Directory of Open Access Journals (Sweden)

Arash Salmaninejad

2017-04-01

Full Text Available Breast cancer is the most commonly diagnosed cancer in women worldwide. Enormous advancement has been made over the last decades in understanding the biology of breast cancer. Nevertheless, the molecular mechanisms regulating progression, gaining of invasive and metastatic phenotypes, and therapeutic resistance are still not completely understood. Oxidative stress initiate by disbalance in redox status of body. In this case, increase of free radicals in body cause tissue damage. One of the significant species of free radicals is reactive oxygen species (ROS that produced by various metabolic pathways, comprising aerobic metabolism in the mitochondrial respiratory chain. They play a serious role in cellular physiology and pathophysiology likewise beginning and evolution of numerous types of cancers. ROS overproduction is deleterious to cells, and considered key-factors for the development of numerous diseases, such as cardiovascular disorders, neurodegenerative diseases, and cancer. Cancer cells are commonly submitted to upper ROS levels that further incite malignant phenotype through motivation to preserved proliferation, angiogenesis, death evasion, invasiveness, and metastasis. ROS impress various signaling pathways, comprising mitogenic pathways and growth factors, and also controls numerous cellular processes, containing cell proliferation, thus stimulates the undisciplined growth of cells which inspires the development of tumors and initiates the progression of carcinogenesis. The importance of ROS on breast cancer development and etiology is being increasingly clarified. Nevertheless, fewer consideration has been given to the progress of redox system-targeted strategies for breast cancer treatment. Augmented oxidative stress caused by reactive species can diminish the body’s antioxidant defense against angiogenesis and metastasis in cancer cells. These processes are core factors in the development of cancer. Bimolecular reactions cause

Large shaft development test plan

International Nuclear Information System (INIS)

Krug, A.D.

1984-03-01

This test plan proposes the conduct of a large shaft development test at the Hanford site in support of the repository development program. The purpose and objective of the test plan is to obtain the information necessary to establish feasibility and to predict the performance of the drilling system used to drill large diameter shafts. The test plan is based upon drilling a 20 ft diameter shaft to a depth of 1,000 feet. The test plan specifies series of tests to evaluate the performance of the downhole assembly, the performance of the rig, and the ability of the system to cope with geologic hazards. The quality of the hole produced will also be determined. This test plan is considered to be preliminary in that it was prepared as input for the decision to determine if development testing is required in this area. Should the decision be made to proceed with development testing, this test plan shall be updated and revised. 6 refs., 2 figs., 3 tabs

Development of Career Progression Systems for Employees in the Foodservice Industry. Final Report.

Science.gov (United States)

National Restaurant Association, Chicago, IL.

Firms representing four segments of the foodservice industry (institutional foodservice (9 jobs), commercial restaurants (19 jobs), hotel foodservice (100 jobs), and airline foodservice (10 jobs), participated in a career and training study to test the feasibility of designing and implementing career progression (c.p.) systems within these…

Structured approach to design of diagnostic test evaluation studies for chronic progressive infections in animals

DEFF Research Database (Denmark)

Nielsen, Søren Saxmose; Toft, Nils; Gardner, Ian Andrew

2011-01-01

Diagnostic test evaluations (DTEs) for chronic infections are challenging because a protracted incubation period has to be considered in the design of the DTE, and the adverse effects of infection may be widespread and progressive over an animal's entire life. Frequently, the specific purpose......) than originally intended. The objective of this paper is to outline a structured approach to the design and conduct of a DTE for diagnostic tests used for chronic infections in animals, and intended for different purposes. We describe the process from reflections about test purpose and the underlying...... of the test is not formally considered when a test is evaluated. Therefore, the result is often a DTE where test sensitivity and specificity estimates are biased, either because of problems with establishing the true infection status or because the test detects another aspect of the infection (and analyte...

FY2011 Progress Report for Energy Storage Research & Development

Energy Technology Data Exchange (ETDEWEB)

none,

2012-01-31

The FY 2011 Progress Report for Energy Storage R&D focuses on advancing the development of batteries to enable a large market penetration of hybrid and electric vehicles. Program targets focus on overcoming technical barriers to enable market success including: (1) significantly reducing battery cost, (2) increasing battery performance (power, energy, durability), (3) reducing battery weight & volume, and (4) increasing battery tolerance to abusive conditions such as short circuit, overcharge, and crush.

Laboratory Directed Research and Development FY 1998 Progress Report

Energy Technology Data Exchange (ETDEWEB)

John Vigil; Kyle Wheeler

1999-04-01

This is the FY 1998 Progress Report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principle investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic, molecular, optical, and plasma physics, fluids, and particle beams, (5) engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.

Laboratory directed research and development: FY 1997 progress report

Energy Technology Data Exchange (ETDEWEB)

Vigil, J.; Prono, J. [comps.

1998-05-01

This is the FY 1997 Progress Report for the Laboratory Directed Research and Development (LDRD) program at Los Alamos National Laboratory. It gives an overview of the LDRD program, summarizes work done on individual research projects, relates the projects to major Laboratory program sponsors, and provides an index to the principal investigators. Project summaries are grouped by their LDRD component: Competency Development, Program Development, and Individual Projects. Within each component, they are further grouped into nine technical categories: (1) materials science, (2) chemistry, (3) mathematics and computational science, (4) atomic and molecular physics and plasmas, fluids, and particle beams, (5) engineering science, (6) instrumentation and diagnostics, (7) geoscience, space science, and astrophysics, (8) nuclear and particle physics, and (9) bioscience.

Soil behavior under earthquake loading conditions. In situ impulse test for determination of shear modulus for seismic response analyses. Progress report

International Nuclear Information System (INIS)

1974-06-01

Progress is reported in the determination of the best methods of evaluation and prediction of soil behavior of potential nuclear power plant sites under seismic loading conditions. Results are reported of combined experimental and analytical studies undertaken to continue development of an in situ impulse test for determination of the soil shear modulus. Emphasis of the field work was directed toward making the field measurements at frequent depth intervals and at shear strains in the strong motion earthquake range. Emphasis of the analytical work was aimed toward supporting the field effort through processing and evaluation of the experimental test results combined with additional calculations required to gain insight into data interpretation and the in situ test setup itself. Continuing studies to evaluate free field soil behavior under earthquake loading conditions are discussed. (U.S.)

Progress of ITER vacuum vessel

Energy Technology Data Exchange (ETDEWEB)

Ioki, K., E-mail: Kimihiro.Ioki@iter.org [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Bayon, A. [F4E, c/ Josep Pla, No. 2, Torres Diagonal Litoral, Edificio B3, E-08019 Barcelona (Spain); Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kim, B.C. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Kuzmin, E. [NTC “Sintez”, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Le Barbier, R.; Martinez, J.-M. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Pathak, H. [ITER-India, A-29, GIDC Electronic Estate, Sector 25, Gandhinagar 382025 (India); Preble, J. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Sa, J.W. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Terasawa, A.; Utin, Yu. [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

2013-10-15

Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure.

Progress of ITER vacuum vessel

International Nuclear Information System (INIS)

Ioki, K.; Bayon, A.; Choi, C.H.; Daly, E.; Dani, S.; Davis, J.; Giraud, B.; Gribov, Y.; Hamlyn-Harris, C.; Jun, C.; Levesy, B.; Kim, B.C.; Kuzmin, E.; Le Barbier, R.; Martinez, J.-M.; Pathak, H.; Preble, J.; Sa, J.W.; Terasawa, A.; Utin, Yu.

2013-01-01

Highlights: ► This covers the overall status and progress of the ITER vacuum vessel activities. ► It includes design, R and D, manufacturing and approval process of the regulators. ► The baseline design was completed and now manufacturing designs are on-going. ► R and D includes ISI, dynamic test of keys and lip-seal welding/cutting technology. ► The VV suppliers produced full-scale mock-ups and started VV manufacturing. -- Abstract: Design modifications were implemented in the vacuum vessel (VV) baseline design in 2011–2012 for finalization. The modifications are mostly due to interface components, such as support rails and feedthroughs for the in-vessel coils (IVC). Manufacturing designs are being developed at the domestic agencies (DAs) based on the baseline design. The VV support design was also finalized and tests on scale mock-ups are under preparation. Design of the in-wall shielding (IWS) has progressed, considering the assembly methods and the required tolerances. Further modifications are required to be consistent with the DAs’ manufacturing designs. Dynamic tests on the inter-modular and stub keys to support the blanket modules are being performed to measure the dynamic amplification factor (DAF). An in-service inspection (ISI) plan has been developed and R and D was launched for ISI. Conceptual design of the VV instrumentation has been developed. The VV baseline design was approved by the agreed notified body (ANB) in accordance with the French Nuclear Pressure Equipment Order procedure

Progress in Development of Kharkov X-Ray Generator Nestor

CERN Document Server

Androsov, V; Botman, J I M; Bulyak, V; Dovbnya, A; Drebot, I; Gladkikh, P; Grevtsev, V; Grigorev, Yu; Gvozd, A; Ivashchenko, V; Karnaukhov, I; Kovalyova, N; Kozin, V; Lapshin, V; Lebedev, A; Lyashchenko, V; Markov, V; Mocheshnikov, N; Molodkin, V; Mytsykov, A; Neklyudov, I; Peev, F; Rezaev, A; Shcherbakov, A; Shpak, A; Skirda, V; Skomorovsky, V I; Tatchyn, R; Telegin, Yu P; Trotsenko, V; Zelinsky, A; Zvonarova, O

2005-01-01

The sources of the X-rays based on Compton scattering of intense Nd:YAG laser beam on electron beam circulating in a storage ring with beam energy 43 - 225 MeV is under construction in NSC KIPT. In the paper the progress in development and construction of Kharkov X-ray generator NESTOR is presented. The current status of the main facility system design and development are described. New scheme and main parameters of injection system are presented. The facility is going to be in operation in the middle of 2007 and generated X-rays flux is expected to be of about 10(13) phot/s.

Recent Progress toward Microfluidic Quality Control Testing of Radiopharmaceuticals

Directory of Open Access Journals (Sweden)

Noel S. Ha

2017-11-01

Full Text Available Radiopharmaceuticals labeled with short-lived positron-emitting or gamma-emitting isotopes are injected into patients just prior to performing positron emission tomography (PET or single photon emission tomography (SPECT scans, respectively. These imaging modalities are widely used in clinical care, as well as in the development and evaluation of new therapies in clinical research. Prior to injection, these radiopharmaceuticals (tracers must undergo quality control (QC testing to ensure product purity, identity, and safety for human use. Quality tests can be broadly categorized as (i pharmaceutical tests, needed to ensure molecular identity, physiological compatibility and that no microbiological, pyrogenic, chemical, or particulate contamination is present in the final preparation; and (ii radioactive tests, needed to ensure proper dosing and that there are no radiochemical and radionuclidic impurities that could interfere with the biodistribution or imaging. Performing the required QC tests is cumbersome and time-consuming, and requires an array of expensive analytical chemistry equipment and significant dedicated lab space. Calibrations, day of use tests, and documentation create an additional burden. Furthermore, in contrast to ordinary pharmaceuticals, each batch of short-lived radiopharmaceuticals must be manufactured and tested within a short period of time to avoid significant losses due to radioactive decay. To meet these challenges, several efforts are underway to develop integrated QC testing instruments that automatically perform and document all of the required tests. More recently, microfluidic quality control systems have been gaining increasing attention due to vastly reduced sample and reagent consumption, shorter analysis times, higher detection sensitivity, increased multiplexing, and reduced instrumentation size. In this review, we describe each of the required QC tests and conventional testing methods, followed by a

Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound

International Nuclear Information System (INIS)

Galvao dos Santos, G.; Reinders, J.; Ouwehand, K.; Rustemeyer, T.; Scheper, R.J.; Gibbs, S.

2009-01-01

Allergic contact dermatitis is the result of an adaptive immune response of the skin to direct exposure to an allergen. Since many chemicals are also allergens, European regulations require strict screening of all ingredients in consumer products. Until recently, identifying a potential allergen has completely relied on animal testing (e.g.: Local Lymph Node Assay). In addition to the ethical problems, both the 7th Amendment to the Cosmetics Directive and REACH have stimulated the development of alternative tests for the assessment of potential sensitizers. This review is aimed at summarising the progress on cell based assays, in particular dendritic cell based assays, being developed as animal alternatives. Primary cells (CD34 + derived dendritic cells, monocyte derived dendritic cells) as well as dendritic cell-like cell lines (THP-1, U-937, MUTZ-3, KG-1, HL-60, and K562) are extensively described along with biomarkers such as cell surface markers, cytokines, chemokines and kinases. From this review, it can be concluded that no single cell based assay nor single marker is yet able to distinguish all sensitizers from non-sensitizers in a test panel of chemicals, nor is it possible to rank the sensitizing potential of the test chemicals. This suggests that sensitivity and specificity may be increased by a tiered assay approach. Only a limited number of genomic and proteomic studies have been completed until now. Such studies have the potential to identify novel biomarkers for inclusion in future assay development. Although progress is promising, this review suggests that it may be difficult to meet the up and coming European regulatory deadlines.

Laboratory Directed Research and Development FY 2000 Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

Los Alamos National Laboratory

2001-05-01

This is the FY00 Annual Progress report for the Laboratory Directed Research and Development (LDRD) Program at Los Alamos National Laboratory. It gives an overview of the LDRD Program, summarizes progress on each project conducted during FY00, characterizes the projects according to their relevance to major funding sources, and provides an index to principal investigators. Project summaries are grouped by LDRD component: Directed Research and Exploratory Research. Within each component, they are further grouped into the ten technical categories: (1) atomic, molecular, optical, and plasma physics, fluids, and beams, (2) bioscience, (3) chemistry, (4) computer science and software engineering, (5) engineering science, (6) geoscience, space science, and astrophysics, (7) instrumentation and diagnostics, (8) materials science, (9) mathematics, simulation, and modeling, and (10) nuclear and particle physics.

Millennium Development Goals progress: a perspective from sub-Saharan Africa

Science.gov (United States)

English, Mike; English, Rex; English, Atti

2015-01-01

Sub-Saharan Africa is a highly diverse geo-political region. Any brief discussion of the progress made over the last 15 years towards the Millennium Development Goals (MDGs) will therefore not do justice to the true complexity of context and events. Our focus will be MDG4—to reduce child mortality by 66% from 1990 levels. We will touch briefly on MDG1, to eradicate extreme poverty and hunger, MDG2, to achieve universal primary education, and MDG5, to improve maternal health, which are inextricably linked with child well-being. We will also draw on an eclectic mix of additional global indicators. Acknowledging the limitations of this approach, we first offer a summary of expected progress and then point to debates on future goals. PMID:25613971

Scenario development and analysis in JNC'S second progress report

International Nuclear Information System (INIS)

Umeki, H.; Makino, H.; Miyahara, K.; Naito, M.

2001-01-01

Scenario development and analysis is an integral part of the performance assessment in the JNC's second progress report which will be issued by the end of November 1999. A systematic approach has been elaborated to ensure traceability and transparency in overall context of the scenario development and set up of calculation cases for assessment of the repository performance. In this approach, the hierarchical FEP matrix was designed to flexibly identify FEPs at different level of detail. The reasoned argument with clearly defined criteria was then applied for screening and grouping of FEPs to define scenarios in the form of influence diagrams. Scenarios and calculation cases were developed based on the expected safety functions of disposal system and relationships with potential detrimental/favorable factors and perturbation factors. The process to develop scenarios and calculation cases are recorded and managed in a computer system. (authors)

Human resource development progress to sustain nuclear science and technology applications in Cameroon

International Nuclear Information System (INIS)

Simo, A.; Nyobe, J.B.

2004-01-01

Full text: Cameroon as a Member of the International Atomic Energy Agency (IAEA) has made full use of the Agency's Technical Co-operation Programme in his effort to promote peaceful applications of nuclear science and technology at national level. This paper presents the progress made in the development of reliable human resources. Results obtained have been achieved through national and regional technical co-operation projects. Over the past twenty years, the development of human resources in nuclear science and technology has focused on the training of national scientists and engineers in various fields such as crop and animal production, human and animal nutrition, human health applications, medical physics, non-destructive testing in industry, groundwater management, maintenance of medical and scientific equipment, radiation protection and radioactive waste management. Efforts made also involve the development of graduate teaching in nuclear sciences at the national universities. However, the lack of adequate training facilities remains a major concern. The development of new training/learning methods is being considered at national level through network linking of national training centres with existing international training institutions, and the use of Information Communication Technologies (ICT) which offer great flexibility with regard to the number of trainees and the actual needs. (author)

Human resource development progress to sustain nuclear science and technology applications in Cameroon

International Nuclear Information System (INIS)

Simo, A.; Nyobe, J.B.

2004-01-01

Cameroon as a Member of the International Atomic Energy Agency (IAEA) has made full use of the Agency's Technical Co-operation Programme in his effort to promote peaceful applications of nuclear science and technology at national level. This paper presents the progress made in the development of reliable human resources. Results obtained have been achieved through national and regional technical co-operation projects. Over the past twenty years, the development of human resources in nuclear science and technology has focussed on the training of national scientists and engineers in various fields such as crop and animal production, human and animal nutrition, human health applications, medical physics, non destructive testing in industry, groundwater management, maintenance of medical and scientific equipment, radiation protection and radioactive waste management. Efforts made also involve the development of graduate teaching in nuclear sciences at the national universities. However, the lack of adequate training facilities remains a major concern. The development of new training/learning methods is being considered at national level through network linking of national training centres with existing international training institutions, and the use of Information Communication Technologies (ICT) which offer great flexibility with regard to the number of trainees and the actual needs. (author)

Recent progress in the development of a B-factory monolithic active pixel detector

International Nuclear Information System (INIS)

Stanic, S.; Aihara, H.; Barbero, M.; Bozek, A.; Browder, T.; Hazumi, M.; Kennedy, J.; Kent, N.; Olsen, S.; Palka, H.; Rosen, M.; Ruckman, L.; Trabelsi, K.; Tsuboyama, T.; Uchida, K.; Varner, G.; Yang, Q.

2006-01-01

Due to the need for precise vertexing at future higher luminosity B-factories with the expectedly increasing track densities and radiation exposures, upgrade of present silicon strip detectors with thin, radiation resistant pixel detectors is highly desired. Considerable progress in the technological development of thin CMOS based Monolithic Active Pixel Sensors (MAPS) in the last years makes them a realistic upgrade option and the feasibility studies of their application in Belle are actively pursued. The most serious concerns are their radiation hardness and their read-out speed. To address them, several prototypes denoted as Continuous Acquisition Pixel (CAP) sensors have been developed and tested. The latest of the CAP sensor prototypes is CAP3, designed in the TSMC 0.25μm process with a 5-deep sample pair pipeline in each pixel. A setup with several CAP3 sensors will be used to assess the performance of a full scale pixel read-out system running at realistic read-out speed. The results and plans for the next stages of R and D towards a full Pixel Vertex Detector (PVD) are presented

Design and development of a continuously variable ratio transmission for an automotive vehicle. Phase IV. Quarterly progress report

Energy Technology Data Exchange (ETDEWEB)

None

1978-05-31

Progress in the design and development of a continuously variable ratio transmission for an automotive vehicle is reported. The Major automotive hydromechanical transmission development problem continues to be the reduction of hydrostatic noise and the project plan, therefore, concentrated on the new hydrostatic module. The potential for achieving acceptably low noise levels in the second generation hydromechanical transmission is to be assessed by comparing the noise levels of the hydrostatic modules for the first and second generation transmissions. A set of twelve test points was selected comprising of road load steady state and wide-open-throttle acceleration at 10, 20, 30, 40, 50 and 60 mph. The module operating conditions for the two transmissions at each of these twelve points were calculated. Baseline noise data was measured on the first generation module. The results are given testing of co-axial hydrostatic module for second generation hydromechanical transmission will be emphasized. (LCL)

Taking stock of Myanmar’s progress toward the health-related Millennium Development Goals: current roadblocks, paths ahead

Science.gov (United States)

2013-01-01

Myanmar is a developing country with considerable humanitarian needs, rendering its pursuit of the Millennium Development Goals (MDGs) an especially high priority. Yet progress to date remains under-examined on key fronts. Particularly within the three health-related MDGs (MDGs 4, 5, and 6), the limited data reported point to patchy levels of achievement. This study was undertaken to provide an overview and assessment of Myanmar’s progress toward the health-related MDGs, along with possible solutions for accelerating health-related development into 2015 and beyond. The review highlights off-track progress in the spheres of maternal and child health (MDGs 4 and 5). It also shows Myanmar’s achievements toward MDG 6 targets – in the areas of HIV/AIDS, malaria, and tuberculosis. Such achievements are especially notable in that Myanmar has been receiving the lowest level of official development assistance among all of the least developed countries in Asia. However, to make similar progress in MDGs 4 and 5, Myanmar needs increased investment and commitment in health. Toward moving forward with the post-2015 development agenda, Myanmar’s government also needs to take the lead in calling for attention from the World Health Organization and its global development partners to address the stagnation in health-related development progress within the country. In particular, Myanmar’s government should invest greater efforts into health system strengthening to pave the road to universal health coverage. PMID:24025845

Assessing progress in the development of safety culture

International Nuclear Information System (INIS)

Rotaru, Ioan; Ghita, Sorin

1999-01-01

visible prescriptive formula for developing a strong safety culture. However, a prerequisite is genuine and consistent commitment by the top management of an organization to improving safety . Providing this commitment exists, the best recommendation is to due something tangible and visible to improve safety, preferably involving employees from the outset. The choice of practices for developing an improved safety culture should take account of the existing national and organizational culture in order to ensure effective implementation. The importance of the learning process has been emphasized. A mechanism is necessary to ensure that international experience of practices to develop a strong safety culture is shared on a regular and frequent basis. The maintenance and improvement of a safety culture is a process of continuous evolution. Indicators are available to assess positive progress in this evolution and to detect a weakening safety culture. (authors)

Chemical Engineering Division Fuel Cycle Programs. Quarterly progress report, October-December 1981

International Nuclear Information System (INIS)

Steindler, M.J.; Bates, J.K.; Cannon, T.F.

1982-05-01

Methods of measuring rates of leaching from simulated waste glasses using neutron activation analysis and radiotracers have been developed. Laboratory-scale impact tests of solid alternative waste forms are being performed to obtain a size analysis of the fragments. Logging techniques are being developed to measure the relative amount of residual oil in a depleted oil reservoir by injecting gamma-active solution into it. Work to test the behavior of radionuclides leached from proposed nuclear-waste repositories using laboratory-analog experiments is in progress. High potassium levels in crushed granite from a Northern Illinois drill hole are probably derived by the leaching of potassium feldspar. Testing and development of equipment for the destructive analysis of full-length irradiated fuel rods from the LWBR are in progress. 19 figures, 13 tables

Development of new low level radioactive waste disposal sites: A progress report

International Nuclear Information System (INIS)

Anderson, Robert T.; Antonucci, George J.; Ryan, Michael T.

1992-01-01

The status of the development of three new low level radioactive waste disposal facilities for the Central Midwest (Illinois), Southeastern (North Carolina) and Appalachian (Pennsylvania) compacts is presented. These three sites will dispose of about 50-65 percent of the commercial low-level waste (LLW) generated in the U.S. annually. Chem-Nuclear, as developer and proposed operator of all three sites has used a common approach to site development. This approach has been based on their twenty-plus years of operating experience and a standard technical approach. The technology employed is an above-grade, multiple engineered barrier design. The paper also contrasts actual progress at each site with a generalized project schedule. Areas of schedule delays are noted along with the steps being taken to accelerate schedule. Finally, we note that continued progress and timely start-up of operations of these new sites is critical on a national basis. This is due to the possibility of near-term closure of the existing LLW disposal sites. (author)

MIT miniaturized disk bend test

International Nuclear Information System (INIS)

Harling, O.K.; Lee, M.; Sohn, D.S.; Kohse, G.; Lau, C.W.

1983-01-01

A miniaturized disk bend test (MDBT) using transmission electron microscopy specimens for the determination of various mechanical properties is being developed at MIT. Recent progress in obtaining strengths and ductilities of highly irradiated metal alloys is reviewed. Other mechanical properties can also be obtained using the MDBT approach. Progress in fatigue testing and in determination of the ductile-to-brittle transition temperature is reviewed briefly. 11 figures

Cryobiotechnology of apple (Malus spp.): development, progress and future prospects.

Science.gov (United States)

Wang, Min-Rui; Chen, Long; Teixeira da Silva, Jaime A; Volk, Gayle M; Wang, Qiao-Chun

2018-05-01

Cryopreservation provides valuable genes for further breeding of elite cultivars, and cryotherapy improves the production of virus-free plants in Malus spp., thus assisting the sustainable development of the apple industry. Apple (Malus spp.) is one of the most economically important temperate fruit crops. Wild Malus genetic resources and existing cultivars provide valuable genes for breeding new elite cultivars and rootstocks through traditional and biotechnological breeding programs. These valuable genes include those resistant to abiotic factors such as drought and salinity, and to biotic factors such as fungi, bacteria and aphids. Over the last three decades, great progress has been made in apple cryobiology, making Malus one of the most extensively studied plant genera with respect to cryopreservation. Explants such as pollen, seeds, in vivo dormant buds, and in vitro shoot tips have all been successfully cryopreserved, and large Malus cryobanks have been established. Cryotherapy has been used for virus eradication, to obtain virus-free apple plants. Cryopreservation provided valuable genes for further breeding of elite cultivars, and cryotherapy improved the production of virus-free plants in Malus spp., thus assisting the sustainable development of the apple industry. This review provides updated and comprehensive information on the development and progress of apple cryopreservation and cryotherapy. Future research will reveal new applications and uses for apple cryopreservation and cryotherapy.

Progress in Development of Kharkov X-Ray Generator Nestor

Energy Technology Data Exchange (ETDEWEB)

Androsov, V.; Bulyak, V.; Dovbnya, A.; Drebot, I.; Gladkikh, P.; Grevtsev, V.; Grigorev, Yu.; Gvozd, A.; Ivashchenko, V.; Karnaukhov, I.; Kovalyova, N.; Kozin, V.; Lapshin, V.; Lyashchenko, V.; Markov, V.; Mocheshnikov, N.; Mytsykov, A.; Neklyudov, I.; Peev, F.; Rezaev, A.; Shcherbakov, A.; /Kharkov, KIPT /SLAC, SSRL /Eindhoven, Tech. U.

2005-09-14

The sources of the X-rays based on Compton scattering of intense Nd:YAG laser beam on electron beam circulating in a storage ring with beam energy 43-225 MeV is under construction in NSC KIPT. In the paper the progress in development and construction of Kharkov X-ray generator NESTOR is presented. The current status of the main facility system design and development are described. New scheme and main parameters of injection system are presented. The status of power supply system and control system is described. The facility is going to be in operation in the middle of 2007 and generated X-rays flux is expected to be of about 10{sup 13} phot/s.

Progress in the development of uranium silicide (U3Si2) fuel at BATAN

International Nuclear Information System (INIS)

Suripto, A.; Soentono, S.

1995-01-01

After successful fabrication of two full-size prototype fuel elements containing ∼3.0 gU/cm 3 in the form of U 3 Si 2 -Al dispersion now undergoing irradiation in the Reaktor Serba Guna G.A. Siwabessy (RSG-GAS) core since 1990, further development in U 3 Si 2 -A2 dispersion fuel element manufacturing has been pursued, whose progress in discussed in this paper, with a special attention on the use of much higher-loading aimed at obtaining a better understanding on the influence of higher-loading on fuel core and plate manufacturing and quality. At present, high-loading U 3 Si 2 -AI dispersion miniplates are being manufactured for preparing some mini-fuel elements to be test-irradiated in the new MTR in-pile loop of the RSG-GAS. (author)

Mycobacterium intracellulare Infection Mimicking Progression of Scleroderma

DEFF Research Database (Denmark)

Krabbe, Simon; Engelhart, Merete; Thybo, Sören

2017-01-01

This case report describes a patient with scleroderma who developed Mycobacterium intracellulare infection, which for more than a year mimicked worsening of her connective tissue disorder. The patient was diagnosed with scleroderma based on puffy fingers that developed into sclerodactyly, abnormal......, unfortunately with significant scarring. Immunodeficiency testing was unremarkable. In summary, an infection with Mycobacterium intracellulare was mistaken for an unusually severe progression of scleroderma....

Progress report on LOFT rake designs

International Nuclear Information System (INIS)

Bearden, R.G.

1977-01-01

Evaluation of data from Loss-of-Fluid Test (LOFT) nonnuclear tests has shown a need for profile measurements at several locations in the LOFT piping. A prototype rake consisting of three Drag-Disc Turbine Transducers (DTT) has been designed and fabricated for installation at one location (FE-BL-1) in the blowdown loop. After successful operation during a LOFT nonnuclear test (L1-4) scheduled for May, 1977, additional rakes will be installed in the primary and blowdown loops. A research program to develop a pitot tube rake for measurement of steady state and transient two-phase flows is in progress at McMaster University, Hamilton, Ontario. A rake of thermocouples and pitot tubes will be developed for installation near the emergency core coolant (ECC) injection points

Tandem Mirror Experiment-Upgrade neutral beam test stand: A powerful tool for development and quality assurance

International Nuclear Information System (INIS)

Hibbs, S.M.; Kane, R.J.; Kerr, R.G.; Poulsen, P.

1983-01-01

During construction of the Tandem Mirror Experiment-Upgrade (TMX-U), a test stand was assembled to develop electronics for the neutral beam system. In the first six months of test stand use the authors operated a few neutral beam injector modules and directed considerable effort toward improving the electronic system. As system development progressed, the focus turned toward improving the injector modules themselves. The test stand has proved to be the largest single contributor to the successful operation of neutral beams on TMX-U, primarily because it provides quality assurance and development capability in conjunction with the scheduled activities of the main experiment. This support falls into five major categories: (1) electronics development, (2) operator training, (3) injector module testing and characterization, (4) injector module improvements, and (5) physics improvements (through areas affected by injector operation). Normal day-to-day operation of the test stand comes under the third category, testing and characterization, and comprises the final quality assurance activity for newly assembled or repaired modules before they are installed on TMX-U. They have also used the test stand to perform a series of physics experiments, including: reducing gas flow through valve and arc chamber characterization, reducing impurities by titanium gettering, and reducing streaming gas using apertures and collisional gas dynamics

The progress reports on the development of therapies of Duchenne muscular dystrophy

Science.gov (United States)

Scheuerbrandt, G

2009-01-01

Summary The roots of the progress reports on the development of therapies for Duchenne muscular dystrophy (DMD) that since 2000 have been produced at Breitnau/Germany and distributed to the parents of DMD patients cover over 30 years of continual occupation with this disease. The beginning was marked by the development of an early detection programme for the genetic disposition for DMD in infant boys. The next step was the organisation of workshops on the management of DMD and the writing of progress reports on these and other relevant conferences. Getting acquainted with the ideas of the protagonists in the research field by holding interviews was a decisive prerequisite for this activity. This took place in tandem with the development of a new kind of multiplex “family letters” that attempted to answer frequently asked questions to many DMD families at the same time. When – with the beginning of the new millennium – the endeavours towards gene therapies for DMD started to boom all over the scientific world, progress reports designed to keep the families informed about research on DMD treatment were added to the family letters. These reports that give an account of the latest state of the research are written in a plain language that can be understood by laypersons. In the meantime the reports have adopted the character of reviews that are updated annually. They are written in English and German and translated into Spanish and many other languages. PMID:20128138

Letter report for the superconducting magnet development program (Number 4). Progress report, June 1, 1975--September 1, 1975

International Nuclear Information System (INIS)

1976-01-01

The program objectives are outlined. Brief discussions of research progress are given for the following: systems design, coil design, conductor selection and test, radiation effects, coil protection, structural analysis and material tests, cryogenics and refrigeration, coil fabrication, and coil test and evaluation

Around Semipalatinsk nuclear test site: Progress of dose estimations relevant to the consequences of nuclear tests

International Nuclear Information System (INIS)

Stepanenko, Valeriy F.; Hoshi, Masaharu; Bailiff, Ian K.

2006-01-01

by RLD and calculations. A possible explanation of the differences between ESR and RLD/calculations doses is the following: for interpretation of ESR data the shielding and behaviour' factors for investigated persons should be taken into account. The 'upper level' of the combination of 'shielding and behaviour' factors of dose reduction for inhabitants of Dolon' village of about 0.28 was obtained by comparing the individual ESR tooth enamel dose estimates with the calculated mean dose for this settlement. The biological dosimetry data related to the settlements near SNTS were presented at the Workshop. A higher incidence of unstable chromosome aberrations, micronucleus in lymphocytes, nuclear abnormalities of thyroid follicular cells, T-cell receptor mutations in peripheral blood were found for exposed areas (Dolan', Sarjal) in comparison with unexposed ones (Kokpekty). The significant greater frequency of stable translocations (results of analyses of chromosome aberrations in lymphocytes by the FISH technique) was demonstrated for Dolon' village in comparison with Chekoman (unexposed village). The elevated level of stable translocations in Dolon' corresponds to a dose of about 180 mSv, which is close to the results of ESR dosimetry for this village. The importance of investigating specific morphological types of thyroid nodules for dosimetry studies was pointed out. In general the 3rd Dosimetry Workshop has demonstrated remarkable progress in developing an international level of common approaches for retrospective dose estimations around the SNTS and in understanding the tasks for the future joint work in this direction. In the framework of a special session the problems of developing a database and registry in order to support epidemiological studies around SNTS were discussed. The results of investigation of psychological consequences of nuclear tests, which are expressed in the form of verbal behaviour, were presented at this session as well. (author)

Progress in developing new commercial LLRW disposal facilities and DOE assistance

International Nuclear Information System (INIS)

Tait, T.D.; Hinschberger, S.T.

1988-01-01

This paper reports state and regional progress in developing new commercial low-level radioactive waste disposal facilities. Specifically the paper addresses DOE determination of state and regional compliance with the 1988 milestone requirements of the Low-Level Radioactive Waste Policy Amendments Act of 1985 (LLRWPAA). In addition, the paper summarizes the assistance provided by the Department of Energy (DOE) to the states and regions in their efforts to develop new disposal facilities as mandated in the LLRWPAA

Poverty and progress: choices for the developing world.

Science.gov (United States)

Chenery, H B

1980-06-01

Some development strategists equate progress with economic growth and others consider increased equity in income distribution or a reduction in poverty as indicators of progress. This report examined the empirical relationship between economic growth and income distribution using data derived from a number of recent comparative studies. Various studies supported the Kuznets hypothesis, which states that during the early phases of development income distribution worsens and improves during the later phases. These studies demonstrated that as per capita income increases in poor countries, income distribution worsens until the per capita income reaches the $800 level. After that level is reached, income distribution generally improves. In a study of 11 countries, the relationship, in recent years, between income growth for the rich and for the poor, and income growth for the country as a whole was examined. Of the 11 countries, Taiwan, Yugoslavia, Sri Lanka, Korea, and Costa Rica were ranked as good performers, since more than 30% of the increment in national income was allocated to the poorest 60% of the population. The countries of India, Philippines, Turkey, and Colombia were ranked as intermediate performers since 20-30% of the increment in national income went to the poorest 60%. Poor performance countries were Brazil, Mexico, and Peru. In these countries less than 20% of the income increment was allocated to the poorest 60%. A table provided comparative national income and income distribution data for the 11 countries. These findings did not permit an assessment of different development strategies; however, they did indicate that: 1) some countries, such as Taiwan, Yugoslavia, and Korea, achieved both rapid growth and greater income distribution equity; and that 2) although some countires, such as Sri Lanka, which stressed equity, grew less rapidly than other countries, such as Mexico, which stressed economic growth, the poor fared much better in the former

RDT&E Progress and Plansfor Hexavalent Chromium (Cr6+)

Science.gov (United States)

2011-05-12

RDT&E Progress and Plans for Hexavalent Chromium (Cr6+) Bruce Sartwell Weapons Systems and Platforms Program Manager E2S2 Conference May 12, 2011...2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE RDT&E Progress and Plansfor Hexavalent Chromium (Cr6+) 5a...Development of Accelerated Corrosion Test Protocols Alternatives to Hex Chrome and Cadmium Plating Alternatives to Hex Chrome Pretreatments

Memory performance on the story recall test and prediction of cognitive dysfunction progression in mild cognitive impairment and Alzheimer's dementia.

Science.gov (United States)

Park, Jong-Hwan; Park, Hyuntae; Sohn, Sang Wuk; Kim, Sungjae; Park, Kyung Won

2017-10-01

To determine the factors that influence diagnosis and differentiation of patients with mild cognitive impairment (MCI) and Alzheimer's dementia (AD) by comparing memory test results at baseline with those at 1-2-year follow up. We consecutively recruited 23 healthy participants, 44 MCI patients and 27 patients with very mild AD according to the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorder Association criteria for probable Alzheimer's disease and Petersen's clinical diagnostic criteria. We carried out detailed neuropsychological tests, including the Story Recall Test (SRT) and the Seoul Verbal Learning Test, for all participants. We defined study participants as the "progression group" as follows: (i) participants who showed conversion to dementia from the MCI state; and (ii) those with dementia who showed more than a three-point decrement in their Mini-Mental State Examination scores with accompanying functional decline from baseline status, which were ascertained by physician's clinical judgment. The SRT delayed recall scores were significantly lower in the patients with mild AD than in those with MCI and after progression. Lower (relative risk 1.1, 95% confidence interval 0.1-1.6) and higher SRT delayed recall scores (relative risk 2.1, confidence interval 1.0-2.8), and two-test combined immediate and delayed recall scores (relative risk 2.0, confidence interval 0.9-2.3; and relative risk 2.8, confidence interval 1.1-4.2, respectively) were independent predictors of progression in a stepwise multiple adjusted Cox proportional hazards model, with age, sex, depression and educational level forced into the model. The present study suggests that the SRT delayed recall score independently predicts progression to dementia in patients with MCI. Geriatr Gerontol Int 2017; 17: 1603-1609. © 2016 Japan Geriatrics Society.

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1993-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1993-03-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions.

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1993-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions.

Development of an extended-burnup Mark B design. Second semiannual progress report, January-June 1979

International Nuclear Information System (INIS)

1979-11-01

The immediate goal of the DOE/AP and L/B and W project is to extend the burnup of light water reactor fuel assemblies beyond present limits to 50,000 MWd/mtU batch average burnup. Fuel management plans and fuel designs are being directed to attain the increased burnup limits. Lead-test assemblies of extended-burnup designs will be manufactured, irradiated in a commercial pressurized water reactor, and examined to support extended-burnup fuel cycles. This report, covering the period from January through June 1979, is the second semiannual progress report for the program. Efforts have included analyses of extended-burnup fuel cycles, developed of both annular fuel pellet and segmented rod designs, and design of a nondestructive post-irradiation examination system

Development of incident progress prediction technologies for nuclear emergency preparedness. Current status and future subjects

International Nuclear Information System (INIS)

Yoshida, Yoshitaka; Yamamoto, Yasunori; Kusunoki, Takayoshi; Kawasaki, Ikuo; Yanagi, Chihiro; Kinoshita, Ikuo; Iwasaki, Yoshito

2014-01-01

Nuclear licensees are required to maintain a prediction system during normal condition for using a nuclear emergency by the Basic Plan for Disaster Prevention of government. With prediction of the incident progress, if the present condition of nuclear power plant is understood appropriately and it grows more serious with keeping the present situation, it is in predicting what kind of situation will be occurred in the near future, choosing the effective countermeasures against the coming threat, and understanding the time available of intervention time. Following the accident on September 30 1999 in the nuclear fuel fabrication facility in Tokai Village of Ibaraki Prefecture, the Institute of Nuclear Safety System started development of incident progress prediction technologies for nuclear emergency preparedness. We have performed technical applications and made improvements in nuclear emergency exercises and verified the developed systems using the observed values of the Fukushima Daiichi Nuclear Power Plant accident. As a result, our developed Incident Progress Prediction System was applied to nuclear emergency exercises and we accumulated knowledge and experience by which we improved the system to make predictions more rapidly and more precisely, including for example, the development of a prediction method for leak size of reactor coolant. On the other hand, if a rapidly progressing incident occurs, since end users need simple and quick predictions about the public's protection and evacuation areas, we developed the Radioactive Materials Release, Radiation Dose and Radiological Protection Area Prediction System which changed solving an inverse problem into a forward problem solution. In view of the water-level-decline incident of the spent fuel storage facility at the Fukushima Daiichi Nuclear Power Plant, the spent fuel storage facility water level and the water temperature evaluation tool were improved. Such incident progress prediction technologies were

The development of Business Ethics in front of the progress of organizational neuroscience and neuroethics

Directory of Open Access Journals (Sweden)

Elsa González Esteban

2017-02-01

Full Text Available Organizational neuroscience and neuroethics are proving to have already made a number of advances in the discovery of both cognition and human behaviour. Those progresses invite us to rethink some of the classical assumptions on which have been developed applied ethics. This article focuses on the analysis about how the progresses of the neurosciences affect our understanding of business ethics and its future development, specially in its organizational level. In order to achieve this objective, the paper is structured in two steps. On the one hand, it considers whether such developments undermine or erode normative foundations of business ethics. On the other hand, it tries to discover the implications of such developments have for business ethics in its practical development.

Consolidated fuel reprocessing program. Progress report, January 1-March 31, 1981

International Nuclear Information System (INIS)

1981-06-01

Progress and activities are reported on process development, laboratory R and D, engineering research, engineering systems, Integrated Equipment Test (IET) facility operations, and HTGR fuel reprocessing

Geothermal drilling and completion technology development program. Quarterly progress report, January-March 1980

Energy Technology Data Exchange (ETDEWEB)

Varnado, S.G. (ed.)

1980-04-01

The progress, status, and results of ongoing Research and Development (R and D) within the Geothermal Drilling and Completion Technology Development Program are described. The program emphasizes the development of geothermal drilling hardware, drilling fluids, completion technology, and lost circulation control methods. Advanced drilling systems are also under development. The goals of the program are to develop the technology required to reduce well costs by 25% by 1983 and by 50% by 1987.

Progress update of NASA's free-piston Stirling space power converter technology project

Science.gov (United States)

Dudenhoefer, James E.; Winter, Jerry M.; Alger, Donald

1992-01-01

A progress update is presented of the NASA LeRC Free-Piston Stirling Space Power Converter Technology Project. This work is being conducted under NASA's Civil Space Technology Initiative (CSTI). The goal of the CSTI High Capacity Power Element is to develop the technology base needed to meet the long duration, high capacity power requirements for future NASA space initiatives. Efforts are focused upon increasing system power output and system thermal and electric energy conversion efficiency at least five fold over current SP-100 technology, and on achieving systems that are compatible with space nuclear reactors. This paper will discuss progress toward 1050 K Stirling Space Power Converters. Fabrication is nearly completed for the 1050 K Component Test Power Converter (CTPC); results of motoring tests of the cold end (525 K), are presented. The success of these and future designs is dependent upon supporting research and technology efforts including heat pipes, bearings, superalloy joining technologies, high efficiency alternators, life and reliability testing, and predictive methodologies. This paper will compare progress in significant areas of component development from the start of the program with the Space Power Development Engine (SPDE) to the present work on CTPC.

Progress in Development of I2S-LWR Concept

International Nuclear Information System (INIS)

Petrovic, Bojan

2014-01-01

The paper will present the progress in developing the Integral Inherently Safe Light Water Reactor (12S-LWR) concept. This new concept aims to combine the competitive economics of a large nuclear power plant, with enhanced safety achieved by the integral primary circuit configuration (previously considered only for PWRs with power levels not exceeding several hundred MWc), and with enhanced accident tolerance (to address concerns after the Fukushima Dai-lchi accidents). Several new technologies are being developed to enable this concept, including novel silicide fuel and micro-channel primary heat exchangers. This project is performed by a multi-disciplinary multi-organization team led by Georgia Tech, including academia, a national laboratory, nuclear industry, and a power utility, wit expected participation of the University of Zagreb. (author)

A Method to Reveal Fine-Grained and Diverse Conceptual Progressions during Learning

Science.gov (United States)

Lombard, François; Merminod, Marie; Widmer, Vincent; Schneider, Daniel K.

2018-01-01

Empirical data on learners' conceptual progression is required to design curricula and guide students. In this paper, we present the Reference Map Change Coding (RMCC) method for revealing students' progression at a fine-grained level. The method has been developed and tested through the analysis of successive versions of the productions of eight…

Progress report physics division 1984 January 1 - June 30

International Nuclear Information System (INIS)

1984-08-01

This report reviews progress made during the first half of 1984 in the following areas: development of the TASCC facility; experimental and theoretical nuclear physics research; development of the heavy-ion superconducting cyclotron, the high current proton accelerator and the electron test accelerator; condensed matter physics; applied mathematics and computer facility operation

Progress report physics division 1984 July 1 - December 31

International Nuclear Information System (INIS)

1985-02-01

This report reviews progress made during the last half of 1984 in the following areas: development of the TASCC facility; experimental and theoretical nuclear physics research; development of the heavy-ion superconducting cyclotron, the high current proton accelerator and the electron test accelerator; condensed matter physics; applied mathematics and computer facility operation

‘Alzheimer’s Progression Score’: Development of a Biomarker Summary Outcome for AD Prevention Trials

Science.gov (United States)

Leoutsakos, J.-M.; Gross, A.L.; Jones, R.N.; Albert, M.S.; Breitner, J.C.S.

2017-01-01

BACKGROUND Alzheimer’s disease (AD) prevention research requires methods for measurement of disease progression not yet revealed by symptoms. Preferably, such measurement should encompass multiple disease markers. OBJECTIVES Evaluate an item response theory (IRT) model-based latent variable Alzheimer Progression Score (APS) that uses multi-modal disease markers to estimate pre-clinical disease progression. DESIGN Estimate APS scores in the BIOCARD observational study, and in the parallel PREVENT-AD Cohort and its sister INTREPAD placebo-controlled prevention trial. Use BIOCARD data to evaluate whether baseline and early APS trajectory predict later progression to MCI/dementia. Similarly, use longitudinal PREVENT-AD data to assess test measurement invariance over time. Further, assess portability of the PREVENT-AD IRT model to baseline INTREPAD data, and explore model changes when CSF markers are added or withdrawn. SETTING BIOCARD was established in 1995 and participants were followed up to 20 years in Baltimore, USA. The PREVENT-AD and INTREPAD trial cohorts were established between 2011–2015 in Montreal, Canada, using nearly identical entry criteria to enroll high-risk cognitively normal persons aged 60+ then followed for several years. PARTICIPANTS 349 cognitively normal, primarily middle-aged participants in BIOCARD, 125 high-risk participants aged 60+ in PREVENT-AD, and 217 similar subjects in INTREPAD. 106 INTREPAD participants donated up to four serial CSF samples. MEASUREMENTS Global cognitive assessment and multiple structural, functional, and diffusion MRI metrics, sensori-neural tests, and CSF concentrations of tau, Aβ42 and their ratio. RESULTS Both baseline values and early slope of APS scores in BIOCARD predicted later progression to MCI or AD. Presence of CSF variables strongly improved such prediction. A similarly derived APS in PREVENT-AD showed measurement invariance over time and portability to the parallel INTREPAD sample. CONCLUSIONS An

Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS.

Science.gov (United States)

Fox, Robert J; Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

2012-11-01

Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS.

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

Science.gov (United States)

Thompson, Alan; Baker, David; Baneke, Peer; Brown, Doug; Browne, Paul; Chandraratna, Dhia; Ciccarelli, Olga; Coetzee, Timothy; Comi, Giancarlo; Feinstein, Anthony; Kapoor, Raj; Lee, Karen; Salvetti, Marco; Sharrock, Kersten; Toosy, Ahmed; Zaratin, Paola; Zuidwijk, Kim

2012-01-01

Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS. PMID:22917690

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. 10 refs

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

Energy Technology Data Exchange (ETDEWEB)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. 10 refs.

Progress and status of the Integral Fast Reactor (IFR) fuel cycle development

International Nuclear Information System (INIS)

Till, C.E.; Chang, Y.I.

1991-01-01

The Integral Fast Reactor (IFR) fuel cycle holds promise for substantial improvements in economics, diversion-resistance, and waste management. This paper discusses technical features of the IFR fuel cycle, its technical progress, the development status, and the future plans and directions. (author)

Power systems development facility. Quarterly technical progress report, July 1--September 30, 1993

Energy Technology Data Exchange (ETDEWEB)

1993-12-31

This quarterly technical progress report summarizes work completed during the Second Quarter of the Second Budget Period, July 1 through September 30, 1993, under the Department of Energy (DOE) Cooperative Agreement No. DE-FC21-90MC25140 entitled ``Hot Gas Cleanup Test Facility for Gasification and Pressurized Combustion.`` The objective of this project is to evaluate hot gas particle control technologies using coal-derived gas streams. This will entail the design, construction, installation, and use of a flexible test facility which can operate under realistic gasification and combustion conditions. The major particulate control device issues to be addressed include the integration of the particulate control devices into coal utilization systems, on-line cleaning techniques, chemical and thermal degradation of components, fatigue or structural failures, blinding, collection efficiency as a function of particle size, and scaleup of particulate control systems to commercial size. The conceptual design of the facility was extended to include a within scope, phased expansion of the existing Hot Gas Cleanup Test Facility Cooperative Agreement to also address systems integration issues of hot particulate removal in advanced coal-based power generation systems. This expansion included the consideration of the following modules at the test facility in addition to the existing Transport Reactor gas source and Hot Gas Cleanup Units: Carbonizer/Pressurized Circulating Fluidized Bed Gas Source. Hot Gas Cleanup Units to mate to all gas streams; Combustion Gas Turbine; and Fuel Cell and associated gas treatment. This expansion to the Hot Gas Cleanup Test Facility is herein referred to as the Power Systems Development Facility (PSDF). The major emphasis during this reporting period was continuing the detailed design of the facility.

Progress in High Power Free-Piston Stirling Convertor Development

Science.gov (United States)

Brandhorst, Henry W., Jr.; Kirby, Raymond L.; Chapman, Peter A.; Walter, Thomas J.

2008-09-01

The U.S. Space Exploration Policy has established a vision for human exploration of the moon and Mars. One option for power for future outposts on the lunar and Martian surfaces is a nuclear reactor coupled with a free-piston Stirling convertor at a power level of 30-40 kWe. A 25 kW convertor was developed in the 1990s under the SP-100 program. This system consisted of two 12.5 kWe engines connected at their hot ends and mounted in tandem to cancel vibration. Recently, NASA began a new project with Auburn University to develop a 5 kWe, single convertor for use in such a possible lunar power system. Goals of this development program include a specific power in excess of 140 We/kg at the convertor level, lifetime in excess of five years and a control system that will safely manage the convertors in case of an emergency. Foster-Miller, Inc. is developing the 5 kWe Stirling Convertor Assembly. The characteristics of the design along with progress in developing the system will be described.

Progress report

International Nuclear Information System (INIS)

Brumovsky, M.

1979-01-01

Progress Report, covering the period up to the end of 1979 year, was sent to the IAEA according to the research agreement No. 1971 /CF. This work covered the following fields: preparation and dummy irradiation experiments with a new experimental capsule of ''CHOUCA-M'' type; measurement of temperature fields and design of specimen holders; measurement of neutron energy spectrum in the irradiation place in our experimental reactor of VVR-S type (Nuclear Research Institute) using a set of activation detectors; unification and calibration of the measurement of neutron fluence with the use of Fe, Cu, Mn-Mg and Co-Al monitors; development and improvement of the measuring apparatus and technique for the dynamic testing of pre-cracked specimens with determination of dynamic parameters of fracture mechanics; preparation and manufacture of testing specimens from the Japanese steels - forging, plate and weld metal; preparation of the irradiation capsule for assembling

Vivitron - Progress report 1990

International Nuclear Information System (INIS)

1991-01-01

The 1990 activity report of the Strasbourg Nuclear Research, concerning the Vivitron project, is presented. After having mounted all the Van de Graaff elements of the Vivitron needed for the generator tests, the tank was closed in July 1990. It was then put under vacuum, leaks were searched for and repaired. Voltage tests started in December and a voltage of 17.6 MV was reached in February. Modifications on the charging system and to improvement of the column protection against sparks are necessary before the voltage tests can be carried on. Great progress has been made in the setting up of the new Vivitron injector and analysing magnet. In this report are included the description of project different development steps, the Vivitron budget and the list of publications, congress contributions and internal reports. 18 figs

Mollusc reproductive toxicity tests - Development and validation of test guidelines

DEFF Research Database (Denmark)

Ducrot, Virginie; Holbech, Henrik; Kinnberg, Karin Lund

. Draft standard operating procedures (SOPs) have been designed based upon literature and expert knowledge from project partners. Pre-validation studies have been implemented to validate the proposed test conditions and identify issues in performing the SOPs and analyzing test results. Pre-validation work......The Organisation for Economic Cooperation and Development is promoting the development and validation of mollusc toxicity tests within its test guidelines programme, eventually aiming for the standardization of mollusc apical toxicity tests. Through collaborative work between academia, industry...... and stakeholders, this study aims to develop innovative partial life-cycle tests on the reproduction of the freshwater gastropods Potamopyrgus antipodarum and Lymnaea stagnalis, which are relevant candidate species for the standardization of mollusc apical toxicity tests assessing reprotoxic effects of chemicals...

Laser development for laser fusion applications research. Progress report, October 1977--March 1978

International Nuclear Information System (INIS)

1978-06-01

Research progress is reported on three laser programs being developed for the commercialization of laser-fusion energy. The lasers include iodine, hydrogen fluoride and Group VI atoms (e.g., O, S, Se, Te)

Millennium Development Goals progress: a perspective from sub-Saharan Africa.

Science.gov (United States)

English, Mike; English, Rex; English, Atti

2015-02-01

Sub-Saharan Africa is a highly diverse geo-political region. Any brief discussion of the progress made over the last 15 years towards the Millennium Development Goals (MDGs) will therefore not do justice to the true complexity of context and events. Our focus will be MDG4-to reduce child mortality by 66% from 1990 levels. We will touch briefly on MDG1, to eradicate extreme poverty and hunger, MDG2, to achieve universal primary education, and MDG5, to improve maternal health, which are inextricably linked with child well-being. We will also draw on an eclectic mix of additional global indicators. Acknowledging the limitations of this approach, we first offer a summary of expected progress and then point to debates on future goals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Proceedings of the international meeting on development, fabrication, and application of Reduced Enrichment fuels for Research and Test Reactors (RERTR). Base technology

Energy Technology Data Exchange (ETDEWEB)

NONE

1983-08-01

The international effort to develop new fuel materials and designs which will make it feasible to fuel research and test reactors throughout the world with low-enrichment uranium, instead of high-enrichment uranium, has made significant progress during the past year. This progress has taken place at research centers located in many different countries, and is of crucial interest to reactor operators and licensors whose geographical distribution is even more varied. It is appropriate, therefore, that international meetings be held periodically to foster direct communication among the specialists in this area. To achieve this purpose, the Reduced Enrichment Research and Test Reactor (RERTR) Program, at the Argonne National Laboratory, sponsored this meeting as the third of a series which begun in 1978. The papers presented at this meeting were divided into sessions according to relevant subject: status of RERTR program and safety issues; development of new fuel types; testing of new fuel elements; specific reactor applications. These proceedings were edited by various members of the RERTR Program.

Proceedings of the international meeting on development, fabrication, and application of Reduced Enrichment fuels for Research and Test Reactors (RERTR). Base technology

International Nuclear Information System (INIS)

1983-08-01

The international effort to develop new fuel materials and designs which will make it feasible to fuel research and test reactors throughout the world with low-enrichment uranium, instead of high-enrichment uranium, has made significant progress during the past year. This progress has taken place at research centers located in many different countries, and is of crucial interest to reactor operators and licensors whose geographical distribution is even more varied. It is appropriate, therefore, that international meetings be held periodically to foster direct communication among the specialists in this area. To achieve this purpose, the Reduced Enrichment Research and Test Reactor (RERTR) Program, at the Argonne National Laboratory, sponsored this meeting as the third of a series which begun in 1978. The papers presented at this meeting were divided into sessions according to relevant subject: status of RERTR program and safety issues; development of new fuel types; testing of new fuel elements; specific reactor applications. These proceedings were edited by various members of the RERTR Program

Test-driven development with Django

CERN Document Server

Harvey, Kevin

2015-01-01

This book is for Django developers with little or no knowledge of test-driven development or testing in general. Familiarity with the command line, setting up a Python virtual environment, and starting a Django project are assumed.

A review of global progress toward the Millennium Development Goal 1 Hunger Target.

Science.gov (United States)

Fanzo, Jessica C; Pronyk, Paul M

2011-06-01

The hunger component of the first Millennium Development Goal (MDG) aims to reduce the proportion of people who suffer from hunger by half between 1990 and 2015. In low- and middle-income countries, progress has been mixed, with approximately 925 million people hungry and 125 million and 195 million children underweight and stunted, respectively. To assess global progress on the hunger component of MDG1 and evaluate the success of interventions and country programs in reducing undernutrition. We review global progress on the hunger component of MDG1, examining experience from 40 community-based programs as well as national efforts to move interventions to scale drawn from the published and gray literature, alongside personal interviews with representatives of governments and development agencies. Based on this review, most strategies being implemented and scaled are focusing on treatment of malnutrition and rooted within the health sector. While critical, these programs generally address disease-related effects and emphasize the immediate determinants of undernutrition. Other major strategies to tackle undernutrition rely on the production of staple grains within the agriculture sector. These programs address hunger, as opposed to improving the quality of diets within communities. Strategies that adopt multisectoral programming as crucial to address longer-term determinants of undernutrition, such as poverty, gender equality, and functioning food and health systems, remain underdeveloped and under-researched. This review suggests that accelerating progress toward the MDG1 targets is less about the development of novel innovations and new technologies and more about putting what is already known into practice. Success will hinge on linking clear policies with effective delivery systems in working towards an evidence-based and contextually relevant multisectoral package of interventions that can rapidly be taken to scale.

Survey of experimental tests about progressive distortion

International Nuclear Information System (INIS)

Clement, Gerard.

1981-02-01

A procedure for evaluation of progressive distorsion experimental data has been set up in CEA. This procedure based on the effective primary stress concept, permits the establishment of a simple design rule. Various published experimental data have been used for verification, validation and generalization of design rule proposed. This rule is compared with existing codified rules (3 Sm, BREE, O'DONNEL and POROWSKI) [fr

FY2011 Annual Progress Report for Advanced Combustion Engine Research and Development

Energy Technology Data Exchange (ETDEWEB)

none,

2011-12-01

Annual Progress Report for the Advanced Combustion Engine Research and Development (R&D) subprogram supporting the mission of the Vehicle Technologies Program by removing the critical technical barriers to commercialization of advanced internal combustion engines (ICEs) for passenger and commercial vehicles that meet future federal emissions regulations.

ERIP invention 637. Technical progress report 2nd quarter, April 1997--June 1997

Energy Technology Data Exchange (ETDEWEB)

Thacker, G.W.

1997-07-22

This technical report describes progress in the development of the Pegasus plow, a stalk and root embedding apparatus. Prototype testing is reported, and includes the addition of precision tillage. Disease data, organic matter, and nitrogen levels results are very briefly described. Progress in marketing is also reported. Current marketing issues include test use by cotton and wheat growers, establishment of dealer relationships, incorporation of design modifications, expansion of marketing activities, and expansion of loan and lease program.

Impact of Scientific and Technological Progress on Economic Development - the Views of Some Nobel Laureates of the Economic Science

OpenAIRE

Florentina Xhelili KRASNIQI; Nexhmie Berisha VOKSHI

2017-01-01

There are different authors' opinions and numerous theories according to which scientific technological progress is a determining factor of the economic development. The paper aims to present the contributions of some Nobel laureates to the impact of scientific and technological progress on economic development such as Arrow, Debreu, Hicks, Solow, Kuznets, Kantorovich and Stiglitz. The research results of their contributions show that scientific technological progress is considered as a sour...

General-purpose heat source project and space nuclear safety and fuels program. Progress report

International Nuclear Information System (INIS)

Maraman, W.J.

1980-02-01

Studies related to the use of 238 PuO 2 in radioisotopic power systems carried out for the Advanced Nuclear Systems and Projects Division of LASL are presented. The three programs involved are: general-purpose heat source development; space nuclear safety; and fuels program. Three impact tests were conducted to evaluate the effects of a high temperature reentry pulse and the use of CBCF on impact performance. Additionally, two 238 PuO 2 pellets were encapsulated in Ir-0.3% W for impact testing. Results of the clad development test and vent testing are noted. Results of the environmental tests are summarized. Progress on the Stirling isotope power systems test and the status of the improved MHW tests are indicated. The examination of the impact failure of the iridium shell of MHFT-65 at a fuel pass-through continued. A test plan was written for vibration testing of the assembled light-weight radioisotopic heater unit. Progress on fuel processing is reported

Nuclear data progress in China (1987 ∼ 1990)

International Nuclear Information System (INIS)

Cai Dunjiu; Yuan Hanrong

1991-01-01

The nuclear data progress from 1987 to 1990 in China were described. It includes nuclear data evaluations and nuclear data library development, development of theory method and code used for nuclear data calculation and evaluation, group constant generating and benchmark testing, nuclear data measurement; international activities and co-operations. These works were carried out by the Chinese Nuclear Data Center and the chinese Nuclear Data Coordination Network

Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer.

Science.gov (United States)

Bruner, Heather C; Derksen, Patrick W B

2018-03-01

Classical cadherins are the key molecules that control cell-cell adhesion. Notwithstanding this function, it is also clear that classical cadherins are more than just the "glue" that keeps the cells together. Cadherins are essential regulators of tissue homeostasis that govern multiple facets of cellular function and development, by transducing adhesive signals to a complex network of signaling effectors and transcriptional programs. In cancer, cadherins are often inactivated or functionally inhibited, resulting in disease development and/or progression. This review focuses on E-cadherin and its causal role in the development and progression of breast and gastric cancer. We provide a summary of the biochemical consequences and consider the conceptual impact of early (mutational) E-cadherin loss in cancer. We advocate that carcinomas driven by E-cadherin loss should be considered "actin-diseases," caused by the specific disruption of the E-cadherin-actin connection and a subsequent dependence on sustained actomyosin contraction for tumor progression. Based on the available data from mouse and human studies we discuss opportunities for targeted clinical intervention. Copyright © 2018 Cold Spring Harbor Laboratory Press; all rights reserved.

When Progressive Disease Does Not Mean Treatment Failure: Reconsidering the Criteria for Progression

Science.gov (United States)

2012-01-01

Although progression-based endpoints, such as progression-free survival, are often key clinical trial endpoints for anticancer agents, the clinical meaning of “objective progression” is much less certain. As scrutiny of progression-based endpoints in clinical trials increases, it should be remembered that the Response Evaluation Criteria In Solid Tumors (RECIST) progression criteria were not developed as a surrogate for survival. Now that progression-free survival has come to be an increasingly important trial endpoint, the criteria that define progression deserve critical evaluation to determine whether alternate definitions of progression might facilitate the development of stronger surrogate endpoints and more meaningful trial results. In this commentary, we review the genesis of the criteria for progression, highlight recent data that question their value as a marker of treatment failure, and advocate for several research strategies that could lay the groundwork for a clinically validated definition of disease progression in solid tumor oncology. PMID:22927506

Development and Validation of a Learning Progression for Change of Seasons, Solar and Lunar Eclipses, and Moon Phases

Science.gov (United States)

Testa, Italo; Galano, Silvia; Leccia, Silvio; Puddu, Emanuella

2015-01-01

In this paper, we report about the development and validation of a learning progression about the Celestial Motion big idea. Existing curricula, research studies on alternative conceptions about these phenomena, and students' answers to an open questionnaire were the starting point to develop initial learning progressions about change of seasons,…

International Study Group Progress Report

Energy Technology Data Exchange (ETDEWEB)

Raubenheimer, Tor O

2000-07-18

The focus of the ISG work was on advancing the accelerator design and supporting technologies. This is a complex process which involves a close interaction between theoretical analysis of the collider design and R and D progress on hardware components. The sequence of efforts took place roughly in the following order: (1) Optimization of the collider parameters and definition of system and subsystem requirements, (2) Identification of design strategies and options, and (3) Development of specific technologies to achieve these requirements. Development and testing of the required components, and R and D on manufacturing techniques have been important activities of the ISG. Experiments at the major test facilities such as the ATF at KEK and ASSET at SLAC have also played a significant role in the ISG studies.

Progress in integrated energy-economy-environment model system development

International Nuclear Information System (INIS)

Yasukawa, Shigeru; Mankin, Shuichi; Sato, Osamu; Tadokoro, Yoshihiro; Nakano, Yasuyuki; Nagano, Takao

1987-11-01

The Integrated Energy-Economy-Environment Model System has been developed for providing analytical tools for the system analysis and technology assessments in the field of nuclear research and development. This model system consists of the following four model groups. The first model block installs 5 models and can serve to analyze and generate long-term scenarios on economy-energy-environment evolution. The second model block installs 2 models and can serve to analyze the structural transition phenomena in energy-economy-environment interactions. The third model block installs 2 models and can handle power reactor installation strategy problem and long-term fuel cycle analysis. The fourth model block installs 5 models and codes and can treats cost-benefit-risk analysis and assessments. This report describes mainly the progress and the outlines of application of the model system in these years after the first report on the research and development of the model system (JAERI-M 84 - 139). (author)

Development of small specimen test techniques. Development of a remote controlled small punch testing apparatus

International Nuclear Information System (INIS)

Ohmi, Masao; Saito, Junichi; Ooka, Norikazu; Jitsukawa, Shiro; Hishinuma, Akimichi; Umino, Akira.

1997-01-01

An accelerator-driven deuterium-lithium (d-Li) stripping reaction-type neutron source, such as the International Fusion Materials Irradiation Facility (IFMIF) planned by the International Energy Agency is recognized as one of the most promising facility to obtain test environments of high-energy neutrons for fusion reactor materials development. The limitation on the available irradiation volume of the irradiation facility requires the development of the small specimen test techniques (SSTT). Application of SSTT to evaluate the degradation of various components in the light water reactor for the life extension is expected to be also quite beneficial. A remote-controlled testing machine for the Small Punch (SP) and miniaturized tensile tests was developed at the hot laboratory of the Japan Materials Testing Reactor (JMTR). The machine is designed for testing at temperatures ranging between 93 and 1,123 K to evaluate the temperature dependence of the strength of materials including the embrittlement at low temperatures and the softening at elevated temperatures. The tests are performed in a vacuum or in an inert gas environment. The machine has been installed in a hot cell and is being used for the round robin test program of the SP test method. The round robin test program is planned to identify the capability of the test method and to establish a standard test procedure. The configuration and the specifications of the test machine are introduced and the results of the SP tests are also shown. (author)

Low-density hydrocarbon foams for laser fusion targets: Progress report, 1987

International Nuclear Information System (INIS)

Haendler, B.L.; Buckley, S.R.; Chen, C.

1988-06-01

This report describes progress made in the development of direct-drive hydrocarbon foam targets for laser inertial confinement fusion during 1987. The foam materials are polystyrene, resorcinol-formaldehyde, carbonized resorcinol-formaldehyde, and cellulose acetate. The processes for making the foams, their properties, characterization techniques, and the relationship of their properties to target specifications are presented. Progress in the creation and testing of prototype targets is also described

The MIT miniaturized disk bend test

International Nuclear Information System (INIS)

Harling, O.K.; Lee, M.; Sohn, D.S.; Kohse, G.; Lau, C.W.

1983-01-01

A miniaturized disk bend test (MDBT) using transmission electron microscopy specimens for the determination of various mechanical properties is being developed at MIT. Recent progress in obtaining strengths and ductilities of highly irradiated metal alloys is reviewed. Possibilities exist for applying the MDBT approach to the determination of other mechanical properties. Progress in fatigue testing and in determination of the ductile-to-brittle transition temperature is reviewed briefly

Consolidated fuel reprocessing program. Progress report, July 1-September 30, 1981

International Nuclear Information System (INIS)

1981-12-01

Technical progress is reported in overview fashion in the following areas: process development, laboratory R and D, engineering research, engineering systems, integrated equipment test facility (IET) operations, and HTGR fuel reprocessing

Annual Progress Report on the Development of Waste Tank Leak Monitoring and Detection and Mitigation Activities in Support of M-45-08

International Nuclear Information System (INIS)

DEFIGH PRICE, C.

2000-01-01

Milestone M-45-09E of the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement or TPA) [TPA 1996] requires submittal of an annual progress report on the development of waste tank leak detection, monitoring, and mitigation (LDMM) activities associated with the retrieval of waste from single-shell tanks (SSTs). This report details progress for fiscal year 2000, building on the current LDMM strategy and including discussion of technologies, applications, cost, schedule, and technical data. The report also includes discussion of demonstrations conducted and recommendations for additional testing. Tri-Party Agreement Milestones M-45-08A and M-45-08B required design and demonstration of LDMM systems for initial retrieval of SST waste. These specific milestones have recently been deleted as part of the M-45-00A change package. Future LDMM development work has been incorporated into specific technology demonstration milestones and SST waste retrieval milestones in the M-45-03 and M-45-05 milestone series

Methodology for developing new test methods

Directory of Open Access Journals (Sweden)

A. I. Korobko

2017-06-01

Full Text Available The paper describes the methodology for developing new test methods and forming solutions for the development of new test methods. The basis of the methodology for developing new test methods is the individual elements of the system and process approaches. They contribute to the development of an effective research strategy for the object, the study of interrelations, the synthesis of an adequate model of the test method. The effectiveness of the developed test method is determined by the correct choice of the set of concepts, their interrelations and mutual influence. This allows you to solve the tasks assigned to achieve the goal. The methodology is based on the use of fuzzy cognitive maps. The question of the choice of the method on the basis of which the model for the formation of solutions is based is considered. The methodology provides for recording a model for a new test method in the form of a finite set of objects. These objects are significant for the test method characteristics. Then a causal relationship is established between the objects. Further, the values of fitness indicators and the observability of the method and metrological tolerance for the indicator are established. The work is aimed at the overall goal of ensuring the quality of tests by improving the methodology for developing the test method.

Progress on development of SPIDER diagnostics

Science.gov (United States)

Pasqualotto, R.; Agostini, M.; Barbisan, M.; Bernardi, M.; Brombin, M.; Cavazzana, R.; Croci, G.; Palma, M. Dalla; Delogu, R. S.; Gorini, G.; Lotto, L.; Muraro, A.; Peruzzo, S.; Pimazzoni, A.; Pomaro, N.; Rizzolo, A.; Serianni, G.; Spolaore, M.; Tardocchi, M.; Zaniol, B.; Zaupa, M.

2017-08-01

SPIDER experiment, the full size prototype of the beam source for the ITER heating neutral beam injector, has to demonstrate extraction and acceleration to 100 kV of a large negative ion hydrogen or deuterium beam with co-extracted electron fraction e-/D- SPIDER plant systems are being installed, the different diagnostic systems are in the procurement phase. Their final design is described here with a focus on some key solutions and most original and cost effective implementations. Thermocouples used to measure the power load distribution in the source and over the beam dump front surface will be efficiently fixed with proven technique and acquired through commercial and custom electronics. Spectroscopy needs to use well collimated lines of sight and will employ novel design spectrometers with higher efficiency and resolution and filtered detectors with custom built amplifiers. The electrostatic probes will be operated through electronics specifically developed to cope with the challenging environment of the RF source. The instrumented calorimeter STRIKE will use new CFC tiles, still under development. Two linear cameras, one built in house, have been tested as suitable for optical beam tomography. Some diagnostic components are off the shelf, others are custom developed: some of these are being prototyped or are under test before final production and installation, which will be completed before start of SPIDER operation.

Test Driven Development of Scientific Models

Science.gov (United States)

Clune, Thomas L.

2012-01-01

Test-Driven Development (TDD) is a software development process that promises many advantages for developer productivity and has become widely accepted among professional software engineers. As the name suggests, TDD practitioners alternate between writing short automated tests and producing code that passes those tests. Although this overly simplified description will undoubtedly sound prohibitively burdensome to many uninitiated developers, the advent of powerful unit-testing frameworks greatly reduces the effort required to produce and routinely execute suites of tests. By testimony, many developers find TDD to be addicting after only a few days of exposure, and find it unthinkable to return to previous practices. Of course, scientific/technical software differs from other software categories in a number of important respects, but I nonetheless believe that TDD is quite applicable to the development of such software and has the potential to significantly improve programmer productivity and code quality within the scientific community. After a detailed introduction to TDD, I will present the experience within the Software Systems Support Office (SSSO) in applying the technique to various scientific applications. This discussion will emphasize the various direct and indirect benefits as well as some of the difficulties and limitations of the methodology. I will conclude with a brief description of pFUnit, a unit testing framework I co-developed to support test-driven development of parallel Fortran applications.

Nuclear reactor safety. Quarterly progress report, October 1--December 31, 1977

International Nuclear Information System (INIS)

Jackson, J.F.; Stevenson, M.G.

1978-02-01

Progress in reactor safety research is summarized. LWR studies include TRAC code development for thermal-hydraulic analysis of accidents, containment systems evaluation, and safety experiments. LMFBR studies include SIMMER code development and applications, modeling of core disruptive accidents, and safety test facilities studies. HTGR safety studies cover fission product release and transport, structural evaluation, phenomena modeling, systems analysis, and accident delineation. GCFR studies are focussed on core disruptive testing

Crossfit training changes brain-derived neurotrophic factor and irisin levels at rest, after wingate and progressive tests, and improves aerobic capacity and body composition of young physically active men and women.

Science.gov (United States)

Murawska-Cialowicz, E; Wojna, J; Zuwala-Jagiello, J

2015-12-01

Brain-derived neurotrophic factor (BDNF) is a protein that stimulates processes of neurogenesis, the survival of neurons and microglia, stimulates neuroplasticity, and takes part in the differentiation of cells developed in the hippocampus. BDNF is also released from skeletal muscles during exercise and can facilitate cross-talk between the nervous and muscular system. Irisin, the exercise hormone, is also released from skeletal muscles and is involved in oxidation processes in the organism. It is a vital issue from the point of view of prophylaxis and treatment through exercise of age-related diseases (e.g. senile dementia), obesity, type-2 diabetes. The aim of the study was to assess the changes in BDNF and irisin levels in young people after a 3-month CrossFit training program. At baseline and after the training, levels of BDNF and irisin were assayed before and after Wingate and progressive tests. Physical performance, body mass and composition, and muscle circumferences were also measured. There were noted: an improvement in aerobic capacity, an increase in VO2max, a reduction in adipose tissue percentage in women and an increase in LBM in all subjects. After CrossFit training the resting BDNF level increased significantly in all subjects while the resting level of irisin decreased in women, without changes in men. The resting level of BDNF at baseline was higher in men than in women. At baseline we observed an increased level of BDNF in women after Wingate and progressive tests, but in men only after the progressive test. After 3 months of CrossFit training the level of BDNF increased in all subjects, and also was higher in men than in women. In women we did not observe significant differences after both tests in comparison to rest. After the training BDNF was lower in men after Wingate and progressive tests than at rest. At baseline irisin level decreased in women after the Wingate and progressive tests. Changes in men were not observed after both tests

Innovative progress and sustainable development of remote sensing for uranium geology

International Nuclear Information System (INIS)

Liu Dechang; Zhao Yingjun; Ye Fawang

2009-01-01

The paper reviewes the innovative process of remote sensing for the uranium geology in Beijing Research Institute of Uranium Geology (BRIUG), discusses the science and technology progress of uranium geology due to remote sensing technique, and the way how to keep sustainable development of the remote sensing for uranium geology so as to play an important role in the uranium geology in the future. (authors)

Recent progress at NASA in LISA formulation and technology development

International Nuclear Information System (INIS)

Stebbins, R T

2008-01-01

Over the last year, the NASA half of the joint LISA project has focused its efforts on responding to a major review, and advancing the formulation and technology development of the mission. The NAS/NRC Beyond Einstein program assessment review will be described, including the outcome. The basis of the LISA science requirements has changed from detection determined by integrated signal-to-noise ratio to observation determined by uncertainty in the estimation of astrophysical source parameters. The NASA team has further defined the spacecraft bus design, participated in many design trade studies and advanced the requirements flow down and the associated current best estimates of performance. Recent progress in technology development is also summarized

Test Driven Development of Scientific Models

Science.gov (United States)

Clune, Thomas L.

2014-01-01

Test-Driven Development (TDD), a software development process that promises many advantages for developer productivity and software reliability, has become widely accepted among professional software engineers. As the name suggests, TDD practitioners alternate between writing short automated tests and producing code that passes those tests. Although this overly simplified description will undoubtedly sound prohibitively burdensome to many uninitiated developers, the advent of powerful unit-testing frameworks greatly reduces the effort required to produce and routinely execute suites of tests. By testimony, many developers find TDD to be addicting after only a few days of exposure, and find it unthinkable to return to previous practices.After a brief overview of the TDD process and my experience in applying the methodology for development activities at Goddard, I will delve more deeply into some of the challenges that are posed by numerical and scientific software as well as tools and implementation approaches that should address those challenges.

Development and Initial Testing of the Tiltrotor Test Rig

Science.gov (United States)

Acree, C. W., Jr.; Sheikman, A. L.

2018-01-01

The NASA Tiltrotor Test Rig (TTR) is a new, large-scale proprotor test system, developed jointly with the U.S. Army and Air Force, to develop a new, large-scale proprotor test system for the National Full-Scale Aerodynamics Complex (NFAC). The TTR is designed to test advanced proprotors up to 26 feet in diameter at speeds up to 300 knots, and even larger rotors at lower airspeeds. This combination of size and speed is unprecedented and is necessary for research into 21st-century tiltrotors and other advanced rotorcraft concepts. The TTR will provide critical data for validation of state-of-the-art design and analysis tools.

Nuclear air cleaning programs in progress in France

International Nuclear Information System (INIS)

Mulcey, P.

1991-01-01

A short presentation is given of the nuclear air cleaning programs in progress in France with respect to pressurized water reactors, fuel reprocessing plants, radioactive waste management facilities, and the dismantling of nuclear facilities. The effects of fires in rooms and ventilation ducts in all nuclear facilities is being studied and computer simulation codes are being developed. A brief review of filter development and filter testing is also presented

Progress toward sustainable development : 1998 sustainable development report of Shell Canada Ltd

International Nuclear Information System (INIS)

1999-04-01

The efforts made by Shell Canada Ltd. to continuously improve the overall environmental performance of their operations and products were reflected in this report. According to the report, in 1998 the company reached or bettered most of their targets, especially for energy conservation and emissions. They also made progress in implementing a health, safety and development management system. The report provides a detailed summary of how the company is managing for sustainability through: (1) regulatory compliance, (2) protecting air and water, (3) conserving energy, (4) protecting soil and groundwater, (5) managing waste, (6) emergency preparedness, (7) ensuring health and safety, (8) social responsibility, and (9) land use and habitat protection. The company's 1999 objectives and targets are also included. 22 figs

Opportunities for Collaborative Adaptive Management Progress: Integrating Stakeholder Assessments into Progress Measurement

Directory of Open Access Journals (Sweden)

Jim Berkley

2013-12-01

There are differences among stakeholders in the indicators they consider as relevant to the assessment of progress. Elucidating these differences can provide useful information about system components and relationships that are important to public support of a CAM program and progress. One of the sources of differences in progress assessments among stakeholders comes from their diverse perceptions about the desired and current states of the social-ecological systems. Stakeholder behavior can be inconsistent between group and individual settings. Individually they may make plans, based on their assessments, that do not conform to the group plan because of their unique interests and preferences. The results of this study need to be further tested. The framework should be used through multiple cycles to determine whether the information gathered with this approach results in additional progress as compared with past approaches. In particular, it would be helpful to test whether gathering such information resulted in a decrease in stakeholders electing to go outside of the CAM process to get their needs met.

LH Dynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity

Directory of Open Access Journals (Sweden)

Rosenfield RobertL

2010-08-01

Full Text Available Background. Excess adiposity and premature adrenarche (PA are risk factors for the development of polycystic ovary syndrome (PCOS. Methods. Girls with slowly progressive precocious breast development, who were overweight and had PA (SPPOPA, 6.2–8.2 years, , overweight PA (6.6–10.8 years, , and overweight premenarcheal controls (OW-PUB, 10.6–12.8 years, underwent hormonal sleep testing and GnRH agonist (GnRHag and ACTH tests. Results. Despite an insignificant sleep-related increase in LH and prepubertal baseline hormone levels, SPPOPA peak LH and estradiol responses to GnRHag were intermediate between those of PA and OW-PUB, the LH being significantly different from both. Conclusions. GnRHag tests indicate that SPPOPA is a slowly progressive form of true puberty with blunted LH dynamics. These results argue against the prepubertal hyperandrogenism of excess adiposity or PA enhancing LH secretion or causing ovarian hyperandrogenism prior to menarche. Excess adiposity may contribute to both the early onset and slow progression of puberty.

Geothermal drilling and completion technology development program. Annual progress report, October 1979-September 1980

Energy Technology Data Exchange (ETDEWEB)

Varnado, S.G. (ed.)

1980-11-01

The progress, status, and results of ongoing research and development (R and D) within the Geothermal Drilling and Completion Technology Development Program are described. The program emphasizes the development of geothermal drilling hardware, drilling fluids, completion technology, and lost circulation control methods. Advanced drilling systems are also under development. The goals of the program are to develop the technology required to reduce well costs by 25% by 1983 and by 50% by 1987.

[Landscape classification: research progress and development trend].

Science.gov (United States)

Liang, Fa-Chao; Liu, Li-Ming

2011-06-01

Landscape classification is the basis of the researches on landscape structure, process, and function, and also, the prerequisite for landscape evaluation, planning, protection, and management, directly affecting the precision and practicability of landscape research. This paper reviewed the research progress on the landscape classification system, theory, and methodology, and summarized the key problems and deficiencies of current researches. Some major landscape classification systems, e. g. , LANMAP and MUFIC, were introduced and discussed. It was suggested that a qualitative and quantitative comprehensive classification based on the ideology of functional structure shape and on the integral consideration of landscape classification utility, landscape function, landscape structure, physiogeographical factors, and human disturbance intensity should be the major research directions in the future. The integration of mapping, 3S technology, quantitative mathematics modeling, computer artificial intelligence, and professional knowledge to enhance the precision of landscape classification would be the key issues and the development trend in the researches of landscape classification.

Recent progress in the development of anode materials for solid oxide fuel cells

Energy Technology Data Exchange (ETDEWEB)

Cowin, Peter I.; Petit, Christophe T.G.; Lan, Rong; Tao, Shanwen [Department of Chemical and Process Engineering, University of Strathclyde, Glasgow G1 1XJ (United Kingdom); Irvine, John T.S. [School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST (United Kingdom)

2011-05-15

The field of research into solid oxide fuel cell (SOFC) anode materials has been rapidly moving forward. In the four years since the last in-depth review significant advancements have been made in the reduction of the operating temperature and improvement of the performance of SOFCs. This progress report examines the developments in the field and looks to draw conclusions and inspiration from this research. A brief introduction is given to the field, followed by an overview of the principal previous materials. A detailed analysis of the developments of the last 4 years is given using a selection of the available literature, concentrating on metal-fluorite cermets and perovskite-based materials. This is followed by a consideration of alternate fuels for use in SOFCs and their associated problems and a short discussion on the effect of synthesis method on anode performance. The concluding remarks compile the significant developments in the field along with a consideration of the promise of future research. The recent progress in the development of anode materials for SOFCs based on oxygen ion conducting electrolytes is reviewed. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

Filter testing and development for prolonged transuranic service and waste reduction

International Nuclear Information System (INIS)

Geer, J.A.; Buttedahl, O.I.; Skaats, C.D.; Terada, K.; Woodard, R.W.

1977-02-01

The life of High Efficiency Particulate Air (HEPA) filters used in transuranic service is influenced greatly by the gaseous and particulate matter to which the filters are exposed. The most severe conditions encountered at Rocky Flats are at the ventilation systems serving the plutonium recovery operations in Bldg. 771. A project of filter testing and development for prolonged transuranic service and waste reduction was formally initiated at Rocky Flats on July 1, 1975. The project is directed toward improving filtration methods which will prolong the life of HEPA filter systems without sacrificing effectiveness. Another important aspect of the project is to reduce the volume of HEPA filter waste shipped from the plant for long-term storage. Progress to September 30, 1976, is reported

[Attempt for development of rapid word reading test for children--evaluation of reliability and validity].

Science.gov (United States)

Hashimoto, Ryusaku; Kashiwagi, Mitsuru; Suzuki, Shuhei

2008-09-01

We developed a rapid word reading test for examining the phonological processing ability of Japanese children. We prepared two versions of the test, version A and B. Each test has word and non-word tasks. Twenty-two healthy boys of third grade in primary schools participated in this validation study. For criterion related validity, we performed the serial Hiragana reading test, the sentence reading test, Raven's coloured progressive matrices (RCPM), the Token test for children, the Kana word dictation test, the standardized comprehension test of abstract words (SCTAW), and Trail Circle test. The reading times of the newly developed test correlated moderately or highly with those of the serial Hiragana reading test and the sentence reading test. However, the scores of the other tests (RCPM, Token test for children, Kana word dictation test, SCTAW, Trail Circle test) did not correlated with the reading time of the rapid word reading test. Test-retest reliabilities in the word tasks were more than moderate: 0.52 and 0.76 in versions A and B, while those in the non-word tasks were high: 0.91 and 0.88 in versions A and B. The correlation coefficient between versions A and B was 0.7 for the word tasks and 0.92 for the non-word tasks. This study showed that the rapid word reading test has substantial validity and reliability for testing the phonological processing ability of Japanese children. In addition, the non-word tasks were more suitable for selectively examining the speed of the grapheme to phoneme conversion process.

Progress of the RERTR [Reduced Enrichment Research and Test Reactor] Program in 1989

International Nuclear Information System (INIS)

Travelli, A.

1989-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program is described. After a brief summary of the results which the RERTR Program, in collaboration with its many international partners, had achieved by the end of 1988, the major events, findings, and activities of 1989 are reviewed. The scope of the RERTR Program activities was curtailed, in 1989, by an unexpected legislative restriction which limited the ability of the Arms Control and Disarmament Agency to adequately fund the program. Nevertheless, the thrust of the major planned program activities was maintained, and meaningful results were obtained in several areas of great significance for future work. 15 refs., 12 figs

Progress in the development of a video-based wind farm simulation technique

OpenAIRE

Robotham, AJ

1992-01-01

The progress in the development of a video-based wind farm simulation technique is reviewed. While improvements have been achieved in the quality of the composite picture created by combining computer generated animation sequences of wind turbines with background scenes of the wind farm site, extending the technique to include camera movements has proved troublesome.

Using Rasch models to develop and validate an environmental thinking learning progression

Science.gov (United States)

Hashimoto-Martell, Erin A.

Environmental understanding is highly relevant in today's global society. Social, economic, and political structures are connected to the state of environmental degradation and exploitation, and disproportionately affect those in poor or urban communities (Brulle & Pellow, 2006; Executive Order No. 12898, 1994). Environmental education must challenge the way we live, and our social and ecological quality of life, with the goal of responsible action. The development of a learning progression in environmental thinking, along with a corresponding assessment, could provide a tool that could be used across environmental education programs to help evaluate and guide programmatic decisions. This study sought to determine if a scale could be constructed that allowed individuals to be ordered along a continuum of environmental thinking. First, I developed the Environmental Thinking Learning Progression, a scale of environmental thinking from novice to advanced, based on the current available research and literature. The scale consisted of four subscales, each measuring a different aspect of environmental thinking: place consciousness, human connection, agency, and science concepts. Second, a measurement instrument was developed, so that the data appropriately fit the model using Rasch analysis. A Rasch analysis of the data placed respondents along a continuum, given the range of item difficulty for each subscale. Across three iterations of instrument revision and data collection, findings indicated that the items were ordered in a hierarchical way that corresponded to the construct of environmental thinking. Comparisons between groups showed that the average score of respondents who had participated in environmental education programs was significantly higher than those who had not. A comparison between males and females showed no significant difference in average measure, however, there were varied significant differences between how racial/ethnic groups performed. Overall

Hazards control progress report No. 57, October-March 1979

International Nuclear Information System (INIS)

Griffith, R.V.

1979-01-01

Progress is reported in research on the following subjects: gas chromatographic/mass spectrometric analysis of thermal degradation products from wood and composite burns; corrosion in the experimental ducting of the fire test cell; on-line x-ray fluorescence analysis of transition metals in waste water: Phase II; fire environmental tests for self-contained breathing apparatus; developments in neutron spectrometry; and, intermediate energy x-ray spectra for general shielding calculations

Progress and Overview on Neutronics Modelling Development in RTP

International Nuclear Information System (INIS)

Mohamad Hairie Rabir; Muhammad Rawi Mohamed Zin; Julia Abdul Karim

2016-01-01

Reactor calculation and simulation are significantly important to ensure safety and better utilization of a research reactor. The Malaysian PUSPATI TRIGA Reactor (RTP) achieved initial criticality on June 28, 1982. The reactor is designed to effectively implement the various fields of basic nuclear research, manpower training, and production of radioisotopes. Since early 90s, neutronics modelling were used as part of its routine in-core fuel management activities. The are several computer codes have been used in RTP since then, based on 1D neutron diffusion, 2D neutron diffusion and 3D Monte Carlo neutron transport method. This paper describes current progress and overview on neutronics modelling development in RTP. Several important parameters were analysed such as k_e_f_f, reactivity, neutron flux, power distribution, B_e_f_f, and fission product build-up for the latest core configuration. The developed core neutronics model was validated by means of comparison with experimental and measurement data. Along with the RTP core model, the calculation procedure also developed to establish better prediction capability of RTP behaviour. (author)

Waste Tank Organic Safety Program: Analytical methods development. Progress report, FY 1994

International Nuclear Information System (INIS)

Campbell, J.A.; Clauss, S.A.; Grant, K.E.

1994-09-01

The objectives of this task are to develop and document extraction and analysis methods for organics in waste tanks, and to extend these methods to the analysis of actual core samples to support the Waste Tank organic Safety Program. This report documents progress at Pacific Northwest Laboratory (a) during FY 1994 on methods development, the analysis of waste from Tank 241-C-103 (Tank C-103) and T-111, and the transfer of documented, developed analytical methods to personnel in the Analytical Chemistry Laboratory (ACL) and 222-S laboratory. This report is intended as an annual report, not a completed work

Impact of Scientific and Technological Progress on Economic Development - the Views of Some Nobel Laureates of the Economic Science

Directory of Open Access Journals (Sweden)

Florentina Xhelili KRASNIQI

2017-12-01

Full Text Available There are different authors' opinions and numerous theories according to which scientific technological progress is a determining factor of the economic development. The paper aims to present the contributions of some Nobel laureates to the impact of scientific and technological progress on economic development such as Arrow, Debreu, Hicks, Solow, Kuznets, Kantorovich and Stiglitz. The research results of their contributions show that scientific technological progress is considered as a source of economic development but this advanced technology to be widely and effectively used should be accompanied by such ideological and institutional adjustments that guarantee the reasonable use of innovations produced by the huge improvements of human knowledge.

Scope and status of the USA Engineering Test Facility including relevant TFTR research and development

International Nuclear Information System (INIS)

Becraft, W.R.; Reardon, P.J.

1980-01-01

The vehicle by which the fusion program would move into the engineering testing phase of fusion power development is designated the Engineering Test Facility (ETF). The progress toward the design and construction of the ETF will reflect the significant achievements of past, present, and future experimental tokamak devices. Some of the features of this foundation of experimental results and relevant engineering designs and operation will derive from the Tokamak Fusion Test Reactor (TFTR) Project, now nearing the completion of its construction phase. The ETF would provide a test-bed for reactor components in the fusion environment. In order to initiate preliminary planning for the ETF decision, the Office of Fusion Energy (OFE) established the ETF Design Center activity to prepare the design of the ETF. This paper describes the design status of the ETF and discusses some highlights of the TFTR R and D work

Scope and status of the USA Engineering Test Facility including relevant TFTR research and development

International Nuclear Information System (INIS)

Becraft, W.R.; Reardon, P.J.

1981-01-01

The vehicle by which the fusion programme would move into the engineering testing phase of fusion power development is designated the Engineering Test Facility (ETF). The progress toward the design and construction of the ETF will reflect the significant achievements of past, present, and future experimental tokamak devices. Some of the features of this foundation of experimental results and relevant engineering designs and operation will derive from the Tokamak Fusion Test Reactor (TFTR) Project, now nearing the completion of its construction phase. The ETF would provide a test-bed for reactor components in the fusion environment. To initiate preliminary planning for the ETF decision, the Office of Fusion Energy (OFE) established the ETF Design Center activity to prepare the design of the ETF. This paper describes the design status of the ETF and discusses some highlights of the TFTR R and D work. (author)

Chemistry research and development. Progress report, July 1977--May 1978

International Nuclear Information System (INIS)

Miner, F.J.

1979-01-01

Studies were continued to determine the compatibility of non-nuclear weapons metals with various production processing materials. The corrosion resistance of 304L stainless steel in mixed acid environment was tested. Intergranular corrosion tests were performed on welded 21-6-9 and 304L stainless steels. A laboratory scale fast fluidized bed incineration system was installed and operating techniques developed. A new uranium chip burning process is being developed. Component development, pilot plant development, and instrumentation and statistical systems development are briefly discussed

Progress of MICE RFCC Module

Energy Technology Data Exchange (ETDEWEB)

Li, D.; Bowring, D.; DeMello, A.; Gourlay, S.; Green, M.; Li, N.; Niinikoski, T.; Pan, H.; Prestemon, S.; Virostek, S.; Zisman, M.; Bross, A.; Carcagno, R.; Kashikhin, V.; Sylvester, C.; Chen, A. B.; Guo, Bin; Li, Liyi; Xu, Fengyu; Cao, Y.; Sun, S.; Wang, Li; Yin, Lixin; Luo, Tianhuan; Summers, Don; Smith, B.; Radovinsky, A.; Zhukovsky, A.; Kaplan, D.

2012-05-20

Recent progress on the design and fabrication of the RFCC (RF and superconducting Coupling Coil) module for the international MICE (Muon Ionization Cooling Experiment) are reported. The MICE ionization cooling channel has two RFCC modules, each having four 201- MHz normal conducting RF cavities surrounded by one superconducting coupling coil (solenoid) magnet. The magnet is designed to be cooled by three cryocoolers. Fabrication of the RF cavities is complete; preparation for the cavity electro-polishing, low power RF measurements, and tuning are in progress at Lawrence Berkeley National Laboratory (LBNL). Fabrication of the cold mass of the first coupling coil magnet has been completed in China and the cold mass arrived at LBNL in late 2011. Preparations for testing the cold mass are currently under way at Fermilab. Plans for the RFCC module assembly and integration are being developed and are described.

Progress on solid breeder TBM at SWIP

International Nuclear Information System (INIS)

Feng, K.M.; Pan, C.H.; Zhang, G.S.; Luo, T.Y.; Zhao, Z.; Chen, Y.J.; Ye, X.F.; Hu, G.; Wang, P.H.; Yuan, T.; Feng, Y.J.; Xiang, B.; Zhang, L.; Wang, Q.J.; Cao, Q.X.; Li, Z.X.; Wang, F.

2010-01-01

Current progress on the design and R and D of Chinese helium-cooled solid breeder test blanket module, CN HCSB TBM is presented. The updated design on structural, neutronics, thermal-hydraulics and safety analysis has been completed. In order to accommodate the HCSB TBM ancillary system, the design and necessary R and Ds corresponding sub-systems have being developed. Current status on the development of function materials, structure material and the helium test loop are also presented. The Chinese low-activation ferritic/martensitic steels CLF-1, which is the structural material for the HCSB TBM is being manufactured by industry. The neutron multiplier Be and tritium breeder Li 4 SiO 4 pebbles are being prepared in laboratory scale.

Molecular Tagging Velocimetry Development for In-situ Measurement in High-Temperature Test Facility

Science.gov (United States)

Andre, Matthieu A.; Bardet, Philippe M.; Burns, Ross A.; Danehy, Paul M.

2015-01-01

The High Temperature Test Facility, HTTF, at Oregon State University (OSU) is an integral-effect test facility designed to model the behavior of a Very High Temperature Gas Reactor (VHTR) during a Depressurized Conduction Cooldown (DCC) event. It also has the ability to conduct limited investigations into the progression of a Pressurized Conduction Cooldown (PCC) event in addition to phenomena occurring during normal operations. Both of these phenomena will be studied with in-situ velocity field measurements. Experimental measurements of velocity are critical to provide proper boundary conditions to validate CFD codes, as well as developing correlations for system level codes, such as RELAP5 (http://www4vip.inl.gov/relap5/). Such data will be the first acquired in the HTTF and will introduce a diagnostic with numerous other applications to the field of nuclear thermal hydraulics. A laser-based optical diagnostic under development at The George Washington University (GWU) is presented; the technique is demonstrated with velocity data obtained in ambient temperature air, and adaptation to high-pressure, high-temperature flow is discussed.

Review of core technologies for development of 2G HTS NMR/MRI magnet: A status report of progress in Korea University

Directory of Open Access Journals (Sweden)

J.B. Song

Full Text Available In this paper, we briefly review our recent progress on development of core technologies for 2G HTS NMR/MRI magnets at Korea University. To outperform the current state-of-art NMR/MRI magnet systems, we have developed the following technologies: 1 a REBCO-REBCO superconducting joint for operation of persistent current mode; 2 partial and grease-insulation winding techniques for self-protection of the HTS magnets; 3 pre-shimming to reduce the screening-current-induced-field; and 4 optimization of multi-width winding to minimize conductor consumption and volume of the HTS magnets. The test results demonstrated the feasibility of employing the developed techniques to achieve ultra-high-field and LHe-free 2G NMR/MRI magnets possessing self-protecting feature.

Gas-Cooled Reactor Programs annual progress report for period ending December 31, 1973

International Nuclear Information System (INIS)

Kasten, P.R.; Coobs, J.H.; Lotts, A.L.

1976-04-01

Progress is summarized in studies relating to HTGR fuel reprocessing, refabrication, and recycle; HTGR fuel materials development and performance testing; HTGR PCRV development; HTGR materials investigations; HTGR fuel chemistry; HTGR safety studies; and GCFR irradiation experiments and steam generator modeling

LFCM [liquid-fed ceramic melter] vitrification technology: Quarterly progress report, January--March 1987

International Nuclear Information System (INIS)

Brouns, R. A.; Allen, C. R.; Powell, J. A.

1988-05-01

This report is compiled by the Nuclear Waste Treatment Program and the Hanford Waste Vitrification Program at Pacific Northwest Laboratory to describe the progress in developing, testing, applying and documenting liquid-fed ceramic melter vitrification technology. Progress in the following technical subject areas during the second quarter of FY 1987 is discussed: melting process chemistry and glass development, feed preparation and transfer systems, melter systems, canister filling and handling systems, and process/product modeling. 23 refs., 14 figs., 10 tabs

YUCCA Mountain Project - Argonne National Laboratory, Annual Progress Report, FY 1997 for activity WP 1221 unsaturated drip condition testing of spent fuel and unsaturated dissolution tests of glass.

Energy Technology Data Exchange (ETDEWEB)

Bates, J. K.; Buck, E. C.; Emery, J. W.; Finch, R. J.; Finn, P. A.; Fortner, J.; Hoh, J. C.; Mertz, C.; Neimark, L. A.; Wolf, S. F.; Wronkiewicz, D. J.

1998-09-18

This document reports on the work done by the Nuclear Waste Management Section of the Chemical Technology Division of Argonne National Laboratory in the period of October 1996 through September 1997. Studies have been performed to evaluate the behavior of nuclear waste glass and spent fuel samples under the unsaturated conditions (low-volume water contact) that are likely to exist in the Yucca Mountain environment being considered as a potential site for a high-level waste repository. Tests with actinide-doped waste glasses, in progress for over 11 years, indicate that the transuranic element release is dominated by colloids that continuously form and span from the glass surface. The nature of the colloids that form in the glass and spent fuel testing programs is being investigated by dynamic light scattering to determine the size distribution, by autoradiography to determine the chemistry, and by zeta potential to measure the electrical properties of the colloids. Tests with UO{sub 2} have been ongoing for 12 years. They show that the oxidation of UO{sub 2} occurs rapidly, and the resulting paragenetic sequence of secondary phases forming on the sample surface is similar to that observed for uranium found in natural oxidizing environments. The reaction of spent fuel samples in conditions similar to those used with UO{sub 2} have been in progress for over six years, and the results suggest that spent fuel forms many of the same alteration products as UO{sub 2}. With spent fuel, the bulk of the reaction occurs via a through-grain reaction process, although grain boundary attack is sufficient to have reacted all of the grain boundary regions in the samples. New test methods are under development to evaluate the behavior of spent fuel samples with intact cladding: the rate at which alteration and radionuclide release occurs when water penetrates fuel sections and whether the reaction causes the cladding to split. Alteration phases have been formed on fine grains of UO

YUCCA Mountain Project - Argonne National Laboratory, Annual Progress Report, FY 1997 for activity WP 1221 unsaturated drip condition testing of spent fuel and unsaturated dissolution tests of glass

International Nuclear Information System (INIS)

Bates, J.K.; Buck, E.C.; Emery, J.W.; Finch, R.J.; Finn, P.A.; Fortner, J.; Hoh, J.C.; Mertz, C.; Neimark, L.A.; Wolf, S.F.; Wronkiewicz, D.J.

1998-01-01

This document reports on the work done by the Nuclear Waste Management Section of the Chemical Technology Division of Argonne National Laboratory in the period of October 1996 through September 1997. Studies have been performed to evaluate the behavior of nuclear waste glass and spent fuel samples under the unsaturated conditions (low-volume water contact) that are likely to exist in the Yucca Mountain environment being considered as a potential site for a high-level waste repository. Tests with actinide-doped waste glasses, in progress for over 11 years, indicate that the transuranic element release is dominated by colloids that continuously form and span from the glass surface. The nature of the colloids that form in the glass and spent fuel testing programs is being investigated by dynamic light scattering to determine the size distribution, by autoradiography to determine the chemistry, and by zeta potential to measure the electrical properties of the colloids. Tests with UO 2 have been ongoing for 12 years. They show that the oxidation of UO 2 occurs rapidly, and the resulting paragenetic sequence of secondary phases forming on the sample surface is similar to that observed for uranium found in natural oxidizing environments. The reaction of spent fuel samples in conditions similar to those used with UO 2 have been in progress for over six years, and the results suggest that spent fuel forms many of the same alteration products as UO 2 . With spent fuel, the bulk of the reaction occurs via a through-grain reaction process, although grain boundary attack is sufficient to have reacted all of the grain boundary regions in the samples. New test methods are under development to evaluate the behavior of spent fuel samples with intact cladding: the rate at which alteration and radionuclide release occurs when water penetrates fuel sections and whether the reaction causes the cladding to split. Alteration phases have been formed on fine grains of UO 2 in contact with

Progress in design, research and development and testing of safety systems for advanced water cooled reactors. Proceedings of a technical committee meeting

International Nuclear Information System (INIS)

1996-04-01

The meeting covered the following topics: Developments in design of safety-related heat removal components and systems for advanced water cooled reactors; status of test programmes on heat removal components and systems of new designs; range of validity and extrapolation of test results for the qualification of design/licensing computer models and codes for advanced water cooled reactors; future needs and trends in testing of safety systems for advanced water cooled reactors. Tests of heat removal safety systems have been conducted by various groups supporting the design, testing and certification of advanced water cooled reactors. The Technical Committee concluded that the reported test results generally confirm the predicted performance features of the advanced designs. Refs, figs, tabs

Progress in design, research and development and testing of safety systems for advanced water cooled reactors. Proceedings of a technical committee meeting

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

The meeting covered the following topics: Developments in design of safety-related heat removal components and systems for advanced water cooled reactors; status of test programmes on heat removal components and systems of new designs; range of validity and extrapolation of test results for the qualification of design/licensing computer models and codes for advanced water cooled reactors; future needs and trends in testing of safety systems for advanced water cooled reactors. Tests of heat removal safety systems have been conducted by various groups supporting the design, testing and certification of advanced water cooled reactors. The Technical Committee concluded that the reported test results generally confirm the predicted performance features of the advanced designs. Refs, figs, tabs.

Development of inactivated poliovirus vaccine from Sabin strains: A progress report.

Science.gov (United States)

Okayasu, Hiromasa; Sein, Carolyn; Hamidi, Ahd; Bakker, Wilfried A M; Sutter, Roland W

2016-11-01

The Global Polio Eradication Initiative (GPEI) has seen significant progress since it began in 1988, largely due to the worldwide use of oral poliovirus vaccine (OPV). In order to achieve polio eradication the global cessation of OPV is necessary because OPV contains live attenuated poliovirus, which in rare circumstances could re-gain wild poliovirus (WPV) characteristics with potential to establish transmission. The GPEI endgame strategy for the period 2013-2018 recommends the globally synchronised sequential cessation of the Sabin strains contained in the OPV, starting with type 2 Sabin. The withdrawal of Sabin type 2 took place in April 2016, with the introduction of at least one dose of inactivated poliovirus vaccine (IPV) as a risk mitigation strategy. The introduction of IPV into 126 countries since 2013 has required a rapid scale-up of IPV production by the two manufacturers supplying the global public sector market. This scale-up has been fraught with challenges, resulting in reductions of 40-50% of initial supply commitments. Consequently, 22 countries will not be supplied until 2018, and another 23 countries will experience serious stock-outs. In the last decade repeated calls-for-action were made to the global community to invigorate their vision and investment in developing "new poliovirus vaccines" including the development of IPV from less-virulent strains, such as Sabin-IPV (S-IPV). The conventional Salk-IPV production is limited to high-income industrialized-country manufacturers due to the containment requirements (i.e., high sanitation, low force-of-poliovirus-infection, and high population immunity). The use of Sabin strains in the production of S-IPV carries a lower biosafety risk, and was determined to be suitable for production in developing countries, expanding the manufacturing base and making IPV more affordable and accessible in the long term. Significant progress in the S-IPV has been made since 2006. S-IPV is now licensed as S-IPV in

Electronic refrigerant leak detector. Quarterly technical progress report

Energy Technology Data Exchange (ETDEWEB)

Talamas, E. Jr.

1998-10-15

The project comprises three main tasks. They are (1) Develop, design, and fabricate sensors, (2) Develop, design, and fabricate test instruments, (3) Testing and data analysis. The milestone includes 17 sub-tasks for the 52-weeks project period, starting on May 1, 1998 and ending on April 30, 1999. As stated in the Application for Federal Assistance, Micronic intended to relocate to a new office by June of 1998. This decision was delayed, since the first partial payment was transferred on August 12, 1998. Micronic plans to relocate this November. A second Provisional Application for a US patent has been filed. Progress made during this period is reported.

Cell cycle in egg cell and its progression during zygotic development in rice.

Science.gov (United States)

Sukawa, Yumiko; Okamoto, Takashi

2018-03-01

Rice egg is arrested at G1 phase probably by OsKRP2. After fusion with sperm, karyogamy, OsWEE1-mediated parental DNA integrity in zygote nucleus, zygote progresses cell cycle to produce two-celled embryo. In angiosperms, female and male gametes exist in gametophytes after the complementation of meiosis and the progression of nuclear/cell division of the haploid cell. Within the embryo sac, the egg cell is specially differentiated for fertilization and subsequent embryogenesis, and cellular programs for embryonic development, such as restarting the cell cycle and de novo gene expression, are halted. There is only limited knowledge about how the cell cycle in egg cells restarts toward zygotic division, although the conversion of the cell cycle from a quiescent and arrested state to an active state is the most evident transition of cell status from egg cell to zygote. This is partly due to the difficulty in direct access and analysis of egg cells, zygotes and early embryos, which are deeply embedded in ovaries. In this study, precise relative DNA amounts in the nuclei of egg cells, developing zygotes and cells of early embryos were measured, and the cell cycle of a rice egg cell was estimated as the G1 phase with a 1C DNA level. In addition, increases in DNA content in zygote nuclei via karyogamy and DNA replication were also detectable according to progression of the cell cycle. In addition, expression profiles for cell cycle-related genes in egg cells and zygotes were also addressed, and it was suggested that OsKRP2 and OsWEE1 function in the inhibition of cell cycle progression in egg cells and in checkpoint of parental DNA integrity in zygote nucleus, respectively.

State of development progress of advanced boiling water reactors

International Nuclear Information System (INIS)

Tomono, Katsuya

1982-01-01

Advanced BWRs being developed at present are those aiming at the improvement of reliability and safety, the reduction of radiation exposure, the improvement of operation performance and capacity ratio of plants, and the heightening of economical efficiency by concentrating the experience and excellent technology of BWR manufacturers in the world. Now in Japan, the independence with Japanese technology is possible in almost all fields of nuclear power generation, and the improvement and standardization project is in progress to obtain the steady results. However, in order to pursue the most desirable BWRs conceivable at present, five BWR manufacturers in the world organized the Advanced Engineering Team in July, 1978, and performed the feasibility study of advanced BWRs for more than one year. Tokyo Electric Power Co., Inc., evaluated the report on the results, and judged that it is desirable to advance into the next stage aiming at the practical use of advanced BWRs. For the purpose, the electric power common research on advanced BWRs has been in progress, and the A-BWR project is to be examined in the third improvement and standardization project of MITI. The main technical features such as the coolant recirculation system of internal pump type, reinforced concrete containment vessels, fine motion control rod drive, improved core and fuel and others are explained. (Kako, I.)

Process development studies on the bioconversion of cellulose and production of ethanol. Progress report, September 1, 1978

Energy Technology Data Exchange (ETDEWEB)

Wilke, C.R.

1978-09-01

Progress is reported in studies on the pretreatment of cellulosic materials to facilitate enzymatic hydrolysis, sulfuric acid hydrolysis, investigation of the Purdue processing scheme including an economic analysis, and the fermentability of the enzymatic hydrolyzate. Progress is also reported on enzyme fermentation studies, hydrolysis reactor development, and utilization of hemicellulose sugars. (JSR)

Progressive geometric algorithms

NARCIS (Netherlands)

Alewijnse, S.P.A.; Bagautdinov, T.M.; de Berg, M.T.; Bouts, Q.W.; ten Brink, Alex P.; Buchin, K.A.; Westenberg, M.A.

2015-01-01

Progressive algorithms are algorithms that, on the way to computing a complete solution to the problem at hand, output intermediate solutions that approximate the complete solution increasingly well. We present a framework for analyzing such algorithms, and develop efficient progressive algorithms

Progressive geometric algorithms

NARCIS (Netherlands)

Alewijnse, S.P.A.; Bagautdinov, T.M.; Berg, de M.T.; Bouts, Q.W.; Brink, ten A.P.; Buchin, K.; Westenberg, M.A.

2014-01-01

Progressive algorithms are algorithms that, on the way to computing a complete solution to the problem at hand, output intermediate solutions that approximate the complete solution increasingly well. We present a framework for analyzing such algorithms, and develop efficient progressive algorithms

Tokamak poloidal field systems. Progress report, January 1-December 31, 1979

International Nuclear Information System (INIS)

Rogers, J.D.

1980-05-01

Work is reported on the development of superconducting tokamak poloidal field systems (TPFS). Progress is discussed on the design of a 20 MJ, 50 kA, 7.5 T superconducting pulsed energy storage coil operated in a 1 to 2 s bipolar mode from +7.5 T to -7.5 T in 1982. Conductor development for the coil is presented. A facility that uses a traction motor energy transfer system to test coils in the 20 to 100 MJ energy range is discussed. Current interrupter development and testing for protection and energy transfer circuits are also presented. The 400 kJ METS coil test preparation is under way

Progress in second-generation HTS wire development and manufacturing

International Nuclear Information System (INIS)

Selvamanickam, V.; Chen, Y.; Xiong, X.; Xie, Y.; Zhang, X.; Rar, A.; Martchevskii, M.; Schmidt, R.; Lenseth, K.; Herrin, J.

2008-01-01

2007 has marked yet another year of continued rapid progress in developing and manufacturing high-performance, long-length second-generation (2G) HTS wires at high speeds. Using ion beam assisted deposition (IBAD) MgO and associated buffer sputtering processes, SuperPower has now exceeded piece lengths of 1000 m of fully buffered tape reproducibly with excellent in-plane texture of 6-7 degrees and uniformity of about 2%. These kilometer lengths are produced at high speeds of about 350 m/h of 4 mm wide tape. In combination with metal organic chemical vapor deposition (MOCVD), 2G wires up to single piece lengths to 790 m with a minimum critical current value of 190 A/cm corresponding to a Critical current x Length performance of 150,100 Am have been achieved. Tape speeds up to 180 m/h have been reached MOCVD while maintaining critical currents above 200 A/cm in 100+ m lengths. Thick film MOCVD technology has been transitioned to Pilot manufacturing system where a minimum critical current of 320 A/cm has been demonstrated over a length of 155 m processed at a speed of 70 m/h in 4 mm width. Finally, nearly 10,000 m of 2G wire has been produced, exhaustively tested, and delivered to the Albany Cable project. The average minimum critical current of the wire delivered in 225 segments of 43-44 m is 70 A in 4 mm widths. A 30 m cable has been fabricated with this wire by Sumitomo Electric and has been installed in the power grid of National Grid in downtown Albany and is the world's first 2G device installed in the grid

Investigation of Spiral Bevel Gear Condition Indicator Validation Via AC-29-2C Using Damage Progression Tests

Science.gov (United States)

Dempsey, Paula J.

2014-01-01

This report documents the results of spiral bevel gear rig tests performed under a NASA Space Act Agreement with the Federal Aviation Administration (FAA) to support validation and demonstration of rotorcraft Health and Usage Monitoring Systems (HUMS) for maintenance credits via FAA Advisory Circular (AC) 29-2C, Section MG-15, Airworthiness Approval of Rotorcraft (HUMS) (Ref. 1). The overarching goal of this work was to determine a method to validate condition indicators in the lab that better represent their response to faults in the field. Using existing in-service helicopter HUMS flight data from faulted spiral bevel gears as a "Case Study," to better understand the differences between both systems, and the availability of the NASA Glenn Spiral Bevel Gear Fatigue Rig, a plan was put in place to design, fabricate and test comparable gear sets with comparable failure modes within the constraints of the test rig. The research objectives of the rig tests were to evaluate the capability of detecting gear surface pitting fatigue and other generated failure modes on spiral bevel gear teeth using gear condition indicators currently used in fielded HUMS. Nineteen final design gear sets were tested. Tables were generated for each test, summarizing the failure modes observed on the gear teeth for each test during each inspection interval and color coded based on damage mode per inspection photos. Gear condition indicators (CI) Figure of Merit 4 (FM4), Root Mean Square (RMS), +/- 1 Sideband Index (SI1) and +/- 3 Sideband Index (SI3) were plotted along with rig operational parameters. Statistical tables of the means and standard deviations were calculated within inspection intervals for each CI. As testing progressed, it became clear that certain condition indicators were more sensitive to a specific component and failure mode. These tests were clustered together for further analysis. Maintenance actions during testing were also documented. Correlation coefficients were

Waste generation and pollution prevention progress fact sheet: Nevada Test Site

International Nuclear Information System (INIS)

1994-01-01

The Nevada Test Site is responsible for maintaining nuclear testing capability, supporting science-based Stockpile Stewardship experiments, maintaining nuclear agency response capability, applying environmental restoration techniques to areas affected by nuclear testing, managing low-level and mixed radioactive waste, investigating demilitarization technologies, investigating counter- proliferation technologies, supporting work-for-others programs and special Department of Defense activities, operating a hazardous materials spill test center, and providing for the commercial development of the site. This fact sheet provides information on routine waste generation and projected reduction by waste type. Also, materials recycled by the Nevada Test Site in 1994 are listed

Psychometric Investigation of the Raven's Colored Progressive Matrices Test in a Sample of Preschool Children.

Science.gov (United States)

Lúcio, Patrícia Silva; Cogo-Moreira, Hugo; Puglisi, Marina; Polanczyk, Guilherme Vanoni; Little, Todd D

2017-11-01

The present study investigated the psychometric properties of the Raven's Colored Progressive Matrices (CPM) test in a sample of preschoolers from Brazil ( n = 582; age: mean = 57 months, SD = 7 months; 46% female). We investigated the plausibility of unidimensionality of the items (confirmatory factor analysis) and differential item functioning (DIF) for sex and age (multiple indicators multiple causes method). We tested four unidimensional models and the one with the best-fit index was a reduced form of the Raven's CPM. The DIF analysis was carried out with the reduced form of the test. A few items presented DIF (two for sex and one for age), confirming that the Raven's CPM items are mostly measurement invariant. There was no effect of sex on the general factor, but increasing age was associated with higher values of the g factor. Future research should indicate if the reduced form is suitable for evaluating the general ability of preschoolers.

The development and validation of testing materials for literacy, numeracy and digital skills in a Dutch context

Science.gov (United States)

de Greef, Maurice; Segers, Mien; Nijhuis, Jan; Lam, Jo Fond; van Groenestijn, Mieke; van Hoek, Frans; van Deursen, Alexander J. A. M.; Bohnenn, Ella; Tubbing, Marga

2015-10-01

Besides work-oriented training, most Dutch adult learning courses of formal and non-formal education focus on three basic skills: literacy, numeracy and problem solving in technology-rich environments. In the Netherlands, the Ministry of Education, Culture and Science recently initiated the development of a new adult education framework concerning literacy, numeracy and digital skills. In order to monitor the progress of literacy, numeracy and digital competencies, it is necessary to develop and validate testing materials for specific competencies. This study validates the testing materials which were developed to assess learners' proficiency in literacy (reading and writing), numeracy and digital skills based on the new Dutch framework. The outcome is that the materials proved valid and can be used in different courses referring to basic skills and adult learning, though there are still some limitations. Besides adult education professionals (such teachers and trainers), policy makers can also use the results of these tests in order to describe and monitor the impact of adult education on the lives of adult learners.

Development of oxygen sensing technology in an irradiated fuel rod. Characteristic test of oxygen sensor

International Nuclear Information System (INIS)

Saito, Junichi; Hoshiya, Taiji; Sakurai, Fumio; Sakai, Haruyuki

1996-03-01

At the Department of JMTR (Japan Materials Test Reactor), the re-instrumentation technologies to a high burnup fuel rod irradiated in an LWR have been developed to study irradiation behavior of the fuel during power transient. It has been progressed developing a chemical sensor as one of the re-instrumentation technologies. This report summarizes the results of characteristic tests of an oxygen sensor made of Yttria Stabilized Zirconia (YSZ) as a solid electrolyte. Several kinds of experiments were carried out to evaluate the electromotive force (emf) performance, stability and lifetime of the oxygen sensor with Ni/NiO, Cr/Cr 2 O 3 and Fe/FeO, respectively as a reference electrode. From the experimental data, it is suggested that the reference electrode of Ni/NiO reveals the most appropriate characteristic of the sensor to measure the partial oxygen pressure in a fuel rod. It is the final goal of this development to clarify the change of oxygen chemical potential in a fuel rod during power transient. (author)

Developing E-Governance in the Eurasian Economic Union: Progress, Challenges and Prospects

Directory of Open Access Journals (Sweden)

Lyudmila Vidiasova

2017-03-01

Full Text Available he article provides an overview of e-governance development in the members of the Eurasian Economic Union (EEU. There is a lack of integrated research on e-governance in the EEU countries, although given the strengthening of this regional bloc, new information and communication technologies (ICT could serve as significant growth driver. Given the history and specifics of regional cooperation in the post-Soviet space and international best practices in ICT use in regional blocs, this article reviews the development of e-governance in the EEU members The research methodology was based on a three-stage concept of regionalism [Van Langenhov, Coste, 2005]. The study examines three key components: progress in developing e-governance, barriers to that development and future prospects. It used qualitative and quantitative methods. Data sources included the results of the United Nations E-Government rating, EEU countries’ regulations based on 3,200 documents and the authors’ expert survey, in which 18 experts (12 EEU representatives and six international experts participated. The study revealed the progress made by EEU countries in improving technological development and reducing human capital development indicators. The survey identified key barriers to e-governance development in the EEU: low motivation and information technology skills among civil servants, and citizens’ low computer literacy. The analysis of EEU members’ national economic priorities revealed a common focus on ICT development. The authors concluded that prospects for e-governance in the EEU were associated with strengthening regional cooperation in standardizing information systems, implementing one-stop-shop services, managing electronic documents and expanding online services. The authors presented two areas for developing e-governance within the EEU. The first is external integration, which, if strengthened, would affect the economy positivelyand optimize business processes

Progress in the development of integrated mental health care in Scotland

Directory of Open Access Journals (Sweden)

Kevin Woods

2002-06-01

Full Text Available The development of integrated care through the promotion of ‘partnership working’ is a key policy objective of the Scottish Executive, the administration responsible for health services in Scotland. This paper considers the extent to which this goal is being achieved in mental health services, particularly those for people with severe and enduring mental illness. Distinguishing between the horizontal and vertical integration of services, exploratory research was conducted to assess progress towards this objective by examining how far a range of functional activities in Primary Care Trusts (PCTs and their constituent Local Health Care Co-operatives (LHCCs were themselves becoming increasingly integrated. All PCTs in Scotland were surveyed by postal questionnaire, and followed up by detailed telephone interviews. Six LHCC areas were selected for detailed case study analysis. A Reference Group was used to discuss and review emerging themes from the fieldwork. The report suggests that faster progress is being made in the horizontal integration of services between health and social care organisations than is the case for vertical integration between primary health care and specialist mental health care services; and that there are significant gaps in the extent to which functional activities within Trusts are changing to support the development of integrated care. A number of models are briefly considered, including the idea of ‘intermediate care’ that might speed the process of integration.

The MSRC research and development program: An update on progress

International Nuclear Information System (INIS)

Engelhardt, F.R.

1993-01-01

The research and development program of the Marine Spill Response Corporation is solidly under way in a variety of project areas. These include remote sensing, in-situ burning, dispersants, oil water separation, countermeasures effectiveness, bioremediation, and evaluation of spill effects. More than thirty projects have been contracted. Among these are remote sensing studies, which started with in-depth market analyses, technical feasibility evaluations, and field studies. The remote sensing program is engaged in rapid development of a research test bed system, as well as longer-term studies on sensor development and use of satellite systems. In-situ burning studies included a detailed analysis of operational feasibility and information needs; preparations are being made for test burns at sea and improvements of fire-resistant barrier systems. Studies are underway on both aerial dispersant application system development and dispersant effects in selected environments. Studies have commenced on the development of oil water separators for vessels of opportunity used in oil spill response, as well as the related issue of demulsification. The effectiveness of spill countermeasures is being investigated from both engineering and ecological perspectives. Bioremediation projects are under way to promote the development of test systems and on shoreline test sites. Interest continues in test spills in the marine environment, including participation in experimental spills outside the United States and a search for possible scenarios where such field experiments can be carried out in United States waters. In all of these project areas, the research and development program stresses information transfer by way of meetings and publications, and is initiating publication of a peer reviewed international journal on oil spill science and technology

Testing Infrastructure for Operating System Kernel Development

DEFF Research Database (Denmark)

Walter, Maxwell; Karlsson, Sven

2014-01-01

Testing is an important part of system development, and to test effectively we require knowledge of the internal state of the system under test. Testing an operating system kernel is a challenge as it is the operating system that typically provides access to this internal state information. Multi......-core kernels pose an even greater challenge due to concurrency and their shared kernel state. In this paper, we present a testing framework that addresses these challenges by running the operating system in a virtual machine, and using virtual machine introspection to both communicate with the kernel...... and obtain information about the system. We have also developed an in-kernel testing API that we can use to develop a suite of unit tests in the kernel. We are using our framework for for the development of our own multi-core research kernel....

The U.S. RERTR program status and progress

International Nuclear Information System (INIS)

Travelli, A.

1998-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program since its inception in 1978 is described. A brief summary of the results which the RERTR Program had achieved by the end of 1996 in collaboration with its many international partners is followed by a detailed review of the major events, findings, and activities of 1997. Significant progress has been made during the past year. In the area of U.S. acceptance of spent fuel from foreign research reactors, several shipments have taken place and additional are being planned. Intense fuel development activities are in progress, including procurement of equipment, screening of candidate materials, and production of microplates. Irradiation of the first series of microplates began in August 1997 in the Advanced Test Reactor, in Idaho. Progress has been made in the Russian RERTR program, which aims to develop and demonstrate within five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with favorable results, controversial performance issues which were raised at last year's meeting. Progress was also made on several aspects of producing molybdenum-99 from fission targets utilizing LEU instead of HEU. Various types of targets and processes are being pursued, with FDA approval of an LEU process projected to occur within two years. The feasibility of LEU Fuel conversion for three important DOE research reactors (BMRR, HFBR, and HFIR) has been evaluated by the RERTR program. In spite of the many momentous events which have occurred during the intervening years, and the excellent progress achieved, the most important challenges that the RERTR program faces today are not very different in type from those that were faced during the first RERTR meeting. Now, as then, the most important task is to develop new LEU fuels satisfying requirements which cannot be satisfied by any

The U.S. RERTR Program. Status and progress

International Nuclear Information System (INIS)

Travelli, A.

1997-01-01

The progress of the Reduced Enrichment Research and Test Reactor (RERTR) Program since its inception in 1978 is described. A brief summary of the results which the RERTR Program had achieved by the end of 1996 in collaboration with its many international partners is followed by a detailed review of the major events, findings, and activities of 1997. Significant progress has been made during the past year. In the area of U.S. acceptance of spent fuel from foreign research reactors, several shipments have taken place and additional are being planned. Intense fuel development activities are in progress, including procurement of equipment, screening of candidate materials, and production of microplates. Irradiation of the first series of microplates began in August 1997 in the Advanced Test Reactor, in Idaho. Progress has been made in the Russian RERTR program, which aims to develop and demonstrate within five years the technical means needed to convert Russian-supplied research reactors to LEU fuels. The study of an alternative LEU core for the FRM-II design has been extended to address, with favorable results, controversial performance issues which were raised at last year's meeting. Progress was also made on several aspects of producing molybdenum-99 from fission targets utilizing LEU instead of HEU. Various types of targets and processes are being pursued, with FDA approval of an LEU process projected to occur within two years. The feasibility of LEU fuel conversion for three important DOE research reactors (BMRR, HFBR, and HFIR) has been evaluated by the RERTR program. In spite of the many momentous events which have occurred during the intervening years, and the excellent progress achieved, the most important challenges that the RERTR program faces today are not very different in type from those that were faced during the first RERTR meeting. Now, as then, the most important task is to develop new LEU fuels satisfying requirements which cannot be satisfied by any

DEVELOPING COMMUNICATIVE LANGUAGE TESTS FOR SENIOR HIGH SCHOOL

Directory of Open Access Journals (Sweden)

Y. M. Harsono

2005-01-01

Full Text Available The Communicative Approach of teaching English in senior high school in Indonesia has been adopted since the implementation of The 1984 Curriculum, but the tests–the communicative language tests–(CL Tests have not been developed and used properly. The objective of the study is to develop CL Tests for senior high school. The procedure of conducting the study consists of three major steps, that is, identifying the objectives, developing the test specification, and developing the CL Tests. The development of the CL Tests in detail consists of fifteen sub-steps from determining what language skills tested, selecting the suitable source materials, up to rewriting the CL Tests to be used as CL Tests alternative for senior high school. The results of the test development reveal that there are fifteen CL Tests consisting of three tests of listening, three reading, three speaking, and three writing tests. The whole tests have construct and content validity, no complete evidence of concurrent validity with report marks and semester test scores, high to very high inter-rater reliability, and no complete practicality.

Cask development, testing, and licensing

International Nuclear Information System (INIS)

Quinn, G.J.; Haelsig, R.T.; Warrant, M.M.

1986-01-01

The NuPac 125-B Rail Cask was developed to provide a safe means of transporting the damaged core of Three Mile Island Unit 2 from the TMI site at Middletown, PA, to the Idaho National Engineering laboratory (INEL) at Idaho Falls, ID. The development of the NuPac 125-B Rail Cask posed two engineering and technical management challenges; Licensing Strategy - The NuPac 125-B Rail Cask represented the first irradiated fuel rail cask developed within the United States in the past decade, a decade characterized by changing nuclear regulations, and Accelerated Schedule - The TMI-2 defueling schedule demanded a cask development schedule one-third as long as normally required. These challenges governed the overall development and licensing process for the cask. First, a high degree of conservation was incorporated into the design to allow quick, simplified demonstrations of adequacy to regulatory staff. Second, redundant design techniques were employed in all areas of uncertainty. The testing program eliminated performance uncertainties and validated predictions and predictive models. Drop tests of a quarter-scale model of the cask were conducted, and results were correlated with analytic predictions to verify structural and mechanical performance of the cask. Full-scale tests of the canisters were conducted to verify structural behavior of canister internals which provide criticality control. This paper describes the testing program for the NuPac 125-B Rail Cask, presents results therefrom, and correlates findings with Regulation 10 CFR 71 of the U.S. Nuclear Regulatory Commission

Tokamak poloidal field systems. Progress report, January 1-December 31, 1980

International Nuclear Information System (INIS)

Rogers, J.D.

1981-03-01

Work is reported on the development of superconducting tokamak poloidal field system (TPFS) program. Progress is discussed on the design of the 20 MJ, 50 kA, 7.5 T superconducting pulsed energy storage coil to be operated in a bipolar mode from +7.5 T to -7.5 T in an energy transfer period of 1.5 to 5 s in 1982 followed by extensive cyclic testing. The facility to conduct the tests uses a traction motor energy transfer system and a nonconducting dewar. Status of the hardware development for the TPFS program is presented. Current interrupter development and testing for protection and energy transfer circuits are also presented. The 400 kJ METS coil test results are given

Can a fatigue test of the isolated lumbar extensor muscles of untrained young men predict strength progression in a resistance exercise program?

NARCIS (Netherlands)

Helmhout, P.; Staal, B.; Dijk, J. van; Harts, C.; Bertina, F.; Bie, R. de

2010-01-01

AIM: The aim of this exploratory study was to investigate the predictive value of a fatigue test of the lumbar extensor muscles for training progression in a group of 28 healthy but predominantly sedentary male students, in an 8-week resistance exercise program. METHODS: A three-phased fatigue test

Development of lubricant test for punching and blanking

DEFF Research Database (Denmark)

Olsson, David Dam

2001-01-01

The background for development of new lubricants Requirements to lubricant test for punching Methods of evaluating lubricants Test equipment developed at DTU Conclusion.......The background for development of new lubricants Requirements to lubricant test for punching Methods of evaluating lubricants Test equipment developed at DTU Conclusion....

Development status of irradiation devices and instrumentation for material and nuclear fuel irradiation tests in HANARO

Energy Technology Data Exchange (ETDEWEB)

Kim, Bong Goo; Sohn, Jae Min; Choo, Kee Nam [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2010-04-15

The High flux Advanced Neutron Application ReactOr (HANARO), an open-tank-in-pool type reactor, is one of the multi-purpose research reactors in the world. Since the commencement of HANARO's operations in 1995, a significant number of experimental facilities have been developed and installed at HANARO, and continued efforts to develop more facilities are in progress. Owing to the stable operation of the reactor and its frequent utilization, more experimental facilities are being continuously added to satisfy various fields of study and diverse applications. The irradiation testing equipment for nuclear fuels and materials at HANARO can be classified into capsules and the Fuel Test Loop (FTL). Capsules for irradiation tests of nuclear fuels in HANARO have been developed for use under the dry conditions of the coolant and materials at HANARO and are now successfully utilized to perform irradiation tests. The FTL can be used to conduct irradiation testing of a nuclear fuel under the operating conditions of commercial nuclear power plants. During irradiation tests conducted using these capsules in HANARO, instruments such as the thermocouple, Linear Variable Differential Transformer (LVDT), small heater, Fluence Monitor (F/M) and Self-Powered Neutron Detector (SPND) are used to measure various characteristics of the nuclear fuel and irradiated material. This paper describes not only the status of HANARO and the status and perspective of irradiation devices and instrumentation for carrying out nuclear fuel and material tests in HANARO but also some results from instrumentation during irradiation tests

Global Monitoring of the CTBT: Progress, Capabilities and Plans (Invited)

Science.gov (United States)

Zerbo, L.

2013-12-01

The Preparatory Commission for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO), established in 1996, is tasked with building up the verification regime of the CTBT. The regime includes a global system for monitoring the earth, the oceans and the atmosphere for nuclear tests, and an on-site inspection (OSI) capability. More than 80% of the 337 facilities of the International Monitoring System (IMS) have been installed and are sending data to the International Data Centre (IDC) in Vienna, Austria for processing. These IMS data along with IDC processed and reviewed products are available to all States that have signed the Treaty. Concurrent with the build-up of the global monitoring networks, near-field geophysical methods are being developed and tested for OSIs. The monitoring system is currently operating in a provisional mode, as the Treaty has not yet entered into force. Progress in installing and operating the IMS and the IDC and in building up an OSI capability will be described. The capabilities of the monitoring networks have progressively improved as stations are added to the IMS and IDC processing techniques refined. Detection thresholds for seismic, hydroacoustic, infrasound and radionuclide events have been measured and in general are equal to or lower than the predictions used during the Treaty negotiations. The measurements have led to improved models and tools that allow more accurate predictions of future capabilities and network performance under any configuration. Unplanned tests of the monitoring network occurred when the DPRK announced nuclear tests in 2006, 2009, and 2013. All three tests were well above the detection threshold and easily detected and located by the seismic monitoring network. In addition, noble gas consistent with the nuclear tests in 2006 and 2013 (according to atmospheric transport models) was detected by stations in the network. On-site inspections of these tests were not conducted as the Treaty has not entered

Perl Testing A Developer's Notebook

CERN Document Server

Langworth, Ian

2005-01-01

Is there any sexier topic in software development than software testing? That is, besides game programming, 3D graphics, audio, high-performance clustering, cool websites, et cetera? Okay, so software testing is low on the list. And that's unfortunate, because good software testing can increase your productivity, improve your designs, raise your quality, ease your maintenance burdens, and help to satisfy your customers, coworkers, and managers. Perl has a strong history of automated tests. A very early release of Perl 1.0 included a comprehensive test suite, and it's only improved from th

Significance of Selective Predation and Development of Prey Protection Measures for Juvenile Salmonids in the Columbia and Snake River Reservoirs: Annual Progress Report, February 1991-February 1992.

Energy Technology Data Exchange (ETDEWEB)

Poe, Thomas P.

1992-12-31

This document is the 1991 annual report of progress for the Bonneville Power Administration (BPA) research Project conducted by the US Fish and Wildlife Service (FWS). Our approach was to present the progress achieved during 1991 in a series of separate reports for each major project task. Each report is prepared in the format of a scientific paper and is able to stand alone, whatever the state of progress or completion. This project has two major goals. One is to understand the significance of selective predation and prey vulnerability by determining if substandard juvenile salmonids (dead, injured, stressed, diseased, or naive) are more vulnerable to predation by northern squawfish, than standard or normal juvenile salmonids. The second goal is to develop and test prey protection measures to control predation on juvenile salmonids by reducing predator-smolt encounters or predator capture efficiency.

Annual progress report on the NSRR experiments, (19)

International Nuclear Information System (INIS)

1991-08-01

Fuel behavior studies in simulated reactivity initiated accident (RIA) conditions have been performed by utilizing Nuclear Safety Research Reactor (NSRR) since October 1975. This report describes the results obtained from experiments performed from January through December, 1987. A total of 38 tests was carried out during this period : those are 5 NSRR standard fuel test, 6 fuel design parameter tests (2 fuel tests with iodine, 3 tests with SUS claddings, and 1 for destructive force measurement test), 7 cooling parameter tests (3 test with flow tube and 4 bundle tests), 8 advanced type fuel tests (1 NRC tests, 5 PCI-resistant fuel tests, 2 pressurized hollow fuel tests), 1 high pressure / high temperature tests, 2 high temperature / high pressure loop tests, 3 high temperature flooding tests, 3 fuel motion observation tests, and 3 miscellaneous atmospheric pressure capsule tests (1 fuel damage test, 2 acceleration tests). The progress of computer code development is also described. (author)

Progress report of the ECN contribution to the experiments in the HAW project

International Nuclear Information System (INIS)

Duijves, K.A.; Vonka, V.

1990-12-01

This progress report documents the progress of the ECN contribution in the High Active Waste experiment, a large-scale in situ test being performed underground at the Asse salt mine in Remlingen FRG, during the period April 1st through June 30th, 1990. In ch. 2 a general overview is given of the experiment development. Problems and solutions are discussed in ch. 3. (author). 4 refs.; 10 figs

Accuracy of progress ratios determined from experience curves: the case of photovoltaic technology development

NARCIS (Netherlands)

van Sark, W.G.J.H.M.|info:eu-repo/dai/nl/074628526; Alsema, E.A.|info:eu-repo/dai/nl/073416258; Junginger, H.M.|info:eu-repo/dai/nl/202130703; de Moor, H.H.C.; Schaeffer, G.J.

2008-01-01

Learning curves are extensively used in policy and scenario studies. Progress ratios (PRs) are derived from historical data and are used for forecasting cost development of many technologies, including photovoltaics (PV). Forecasts are highly sensitive to uncertainties in the PR. A PR usually is

Environment, safety and health progress assessment manual

International Nuclear Information System (INIS)

1992-12-01

On June 27, 1989, the Secretary of Energy announced a 10-Point Initiative to strengthen environment, safety, and health (ES ampersand H) programs, and waste management activities at DOE production, research, and testing facilities. One of the points involved conducting dent Tiger Team Assessments of DOE operating facilities. The Office of Special independent Projects (OSP), EH-5, in the Office of the Assistant Secretary for Environment, Safety and Health, EH-1, was assigned the responsibility to conduct the Tiger Team Assessments. Through June 1992, a total of 35 Tiger Team Assessments were completed. The Secretary directed that Corrective Action Plans be developed and implemented to address the concerns identified by the Tiger Teams. In March 1991, the Secretary approved a plan for assessments that are ''more focused, concentrating on ES ampersand H management, ES ampersand H corrective actions, self-assessment programs, and root-cause related issues.'' In July 1991, the Secretary approved the initiation of ES ampersand H Progress Assessments, as a followup to the Tiger Team Assessments, and in the continuing effort to institutionalize the self-assessment process and line management accountability in the ES ampersand H areas. This manual documents the processes to be used to perform the ES ampersand H Progress Assessments. It was developed based upon the lessons learned from Tiger Team Assessments, the two pilot Progress Assessments, and Progress Assessments that have been completed. The manual will be updated periodically to reflect lessons learned or changes in policy

Understanding Urban Communication in Information Era: Analyzing Development Progress of Coastal Territories in the Context of West Java’s Metropolitan Regions

Science.gov (United States)

Sutriadi, Ridwan; Indriyani Kurniasari, Meta

2017-07-01

This paper explores a consequence of metropolitan and development centers policy to the development progress of coastal territories by analyzing municipal website base on urban communication functions of communicative city concept. In terms of coastal territories as a part of development center, efforts have to be made in enhancing the role and function of municipal website to show their development progress. Perceptual analysis is taken as a method to measure their position, especially kabupaten/kota as coastal territories in regional context (West Java Province). The results indicate that the availability of public information in coastal territories cities lower than other cities in metropolitan area. Innovation in specifying coastal features has to be promoted in illustrating development progress of coastal territories as a part of development centers in West Java Province.

Geochemical Testing And Model Development - Residual Tank Waste Test Plan

International Nuclear Information System (INIS)

Cantrell, K.J.; Connelly, M.P.

2010-01-01

This Test Plan describes the testing and chemical analyses release rate studies on tank residual samples collected following the retrieval of waste from the tank. This work will provide the data required to develop a contaminant release model for the tank residuals from both sludge and salt cake single-shell tanks. The data are intended for use in the long-term performance assessment and conceptual model development.

Progress of research and development of nuclear fusion and development of large nuclear fusion device technology

International Nuclear Information System (INIS)

1994-01-01

In the last several years, the results of tokamak experiments were conspicuous, and the progress of plasma confinement performance, transport mechanism, divertors and impurities, helium transport and exhaust, electric current drive, magnetic field ripple effect and high speed particle transport and DT experiment are reported. The other confinement methods than tokamak, the related theories and reactor technology are described. The conceptual design of ITER was carried out by the cooperation of Japan, USA, EC and the former USSR. The projects of developing nuclear fusion in various countries, the design and the required research and development of ITER, the reconstruction and the required research and development of JT-60, JET and TFTR, the design and the required research and development of large helical device, the state of research and development of laser nuclear fusion and inversion magnetic field pinch nuclear fusion, the activities and roles of industrial circles in large nuclear fusion device technology, and the long term perspective of the technical development of nuclear fusion are described. (K.I.)

AngularJS test-driven development

CERN Document Server

Chaplin, Tim

2015-01-01

This book is for developers who want to learn about AngularJS development by applying testing techniques. You are assumed to have a basic knowledge and understanding of HTML, JavaScript, and AngularJS.

Progress in second-generation HTS wire development and manufacturing

Energy Technology Data Exchange (ETDEWEB)

Selvamanickam, V. [SuperPower, Inc., 450 Duane Avenue, Schenectady, NY 12304 (United States)], E-mail: vselva@superpower-inc.com; Chen, Y.; Xiong, X.; Xie, Y.; Zhang, X.; Rar, A.; Martchevskii, M.; Schmidt, R.; Lenseth, K.; Herrin, J. [SuperPower, Inc., 450 Duane Avenue, Schenectady, NY 12304 (United States)

2008-09-15

2007 has marked yet another year of continued rapid progress in developing and manufacturing high-performance, long-length second-generation (2G) HTS wires at high speeds. Using ion beam assisted deposition (IBAD) MgO and associated buffer sputtering processes, SuperPower has now exceeded piece lengths of 1000 m of fully buffered tape reproducibly with excellent in-plane texture of 6-7 degrees and uniformity of about 2%. These kilometer lengths are produced at high speeds of about 350 m/h of 4 mm wide tape. In combination with metal organic chemical vapor deposition (MOCVD), 2G wires up to single piece lengths to 790 m with a minimum critical current value of 190 A/cm corresponding to a Critical current x Length performance of 150,100 Am have been achieved. Tape speeds up to 180 m/h have been reached MOCVD while maintaining critical currents above 200 A/cm in 100+ m lengths. Thick film MOCVD technology has been transitioned to Pilot manufacturing system where a minimum critical current of 320 A/cm has been demonstrated over a length of 155 m processed at a speed of 70 m/h in 4 mm width. Finally, nearly 10,000 m of 2G wire has been produced, exhaustively tested, and delivered to the Albany Cable project. The average minimum critical current of the wire delivered in 225 segments of 43-44 m is 70 A in 4 mm widths. A 30 m cable has been fabricated with this wire by Sumitomo Electric and has been installed in the power grid of National Grid in downtown Albany and is the world's first 2G device installed in the grid.

Progress on Variable Cycle Engines

Science.gov (United States)

Westmoreland, J. S.; Howlett, R. A.; Lohmann, R. P.

1979-01-01

Progress in the development and future requirements of the Variable Stream Control Engine (VSCE) are presented. The two most critical components of this advanced system for future supersonic transports, the high performance duct burner for thrust augmentation, and the low jet coannular nozzle were studied. Nozzle model tests substantiated the jet noise benefit associated with the unique velocity profile possible with a coannular nozzle system on a VSCE. Additional nozzle model performance tests have established high thrust efficiency levels only at takeoff and supersonic cruise for this nozzle system. An experimental program involving both isolated component and complete engine tests has been conducted for the high performance, low emissions duct burner with good results and large scale testing of these two components is being conducted using a F100 engine as the testbed for simulating the VSCE. Future work includes application of computer programs for supersonic flow fields to coannular nozzle geometries, further experimental testing with the duct burner segment rig, and the use of the Variable Cycle Engine (VCE) Testbed Program for evaluating the VSCE duct burner and coannular nozzle technologies.

Developing and validating a predictive model for stroke progression

OpenAIRE

Craig, L.E.; Wu, Olivia; Gilmour, H.; Barber, M.; Langhorne, P.

2011-01-01

Background: Progression is believed to be a common and important complication in acute stroke, and has been associated with increased mortality and morbidity. Reliable identification of predictors of early neurological deterioration could potentially benefit routine clinical care. The aim of this study was to identify predictors of early stroke progression using two independent patient cohorts. \\ud \\ud Methods: Two patient cohorts were used for this study – the first cohort formed the trainin...

UCLA accelerator research ampersand development. Progress report

International Nuclear Information System (INIS)

1997-01-01

This report discusses work on advanced accelerators and beam dynamics at ANL, BNL, SLAC, UCLA and Pulse Sciences Incorporated. Discussed in this report are the following concepts: Wakefield acceleration studies; plasma lens research; high gradient rf cavities and beam dynamics studies at the Brookhaven accelerator test facility; rf pulse compression development; and buncher systems for high gradient accelerator and relativistic klystron applications

Development of an aging evaluation and life extension program for the Advanced Test Reactor

International Nuclear Information System (INIS)

Dwight, J.E. Jr.

1988-01-01

A life extension program has been developed for the US Department of Energy's Advanced Test Reactor. The program is an adaptation of life extension pilot programs at the Surry Unit 1 and Monticello generating stations and is being completed in three phases. In Phase 1, the critical plant components were identified. In Phase 2, existing lifetime analyses and support data for the critical components were reviewed. The results from the review give a preliminary indication that an overall plant lifetime in excess of forty years is feasible. In Phase 3, now in progress, detailed evaluations for component life extensions are being performed. 2 refs., 2 figs., 1 tab

Expression of XPG protein in the development, progression and prognosis of gastric cancer.

Directory of Open Access Journals (Sweden)

Na Deng

Full Text Available BACKGROUND: Xeroderma pigmentosum group G (XPG plays a critical role in preventing cells from oxidative DNA damage. This study aimed to investigate XPG protein expression in different gastric tissues and in patients with diverse prognoses, thus providing insights into its role in the development, progression and prognosis of gastric cancer (GC. METHODS: A total of 176 GC, 131 adjacent non-tumour tissues, 53 atrophic gastritis (AG and 49 superficial gastritis (SG samples were included. Immunohistochemical staining was used to detect XPG protein expression. RESULTS: XPG expression was significantly higher in GC tissues compared with adjacent non-tumour tissues. In the progressive disease sequence SG→AG→GC, XPG expression was significantly higher in AG and GC compared with SG. Analysis of clinicopathological parameters and survival in GC patients demonstrated a significant association between XPG expression level and depth of tumour invasion, macroscopic type, Lauren's classification, smoking, Helicobacter pylori infection and family history. Cox multivariate survival analysis indicated that patients with positive XPG expression had significantly longer overall survival (P = 0.020, HR = 0.394, 95%CI 0.179-0.866, especially in aged younger than 60 years (P = 0.027, HR = 0.361, 95%CI 0.147-0.888 and male patients (P = 0.002, HR = 0.209, 95%CI 0.077-0.571. CONCLUSIONS: This study demonstrated that XPG protein expression was related to the development, progression and prognosis of GC, and might thus serve as a potential biomarker for its diagnosis and prognosis.

Instrumentation and Controls Division biennial progress report, September 1, 1976--September 1, 1978

Energy Technology Data Exchange (ETDEWEB)

Sadowski, G.S. (ed.)

1978-11-01

Progress is summarized in the following research and development areas: electronic circuits;instruments; radiation monitoring; process systems and instrumentation; thermometry; instrumentation for engineering experiments and test loops; HTGR fuel recycle development; reactor measurements and analysis; automatic control and data acquisition; electronic engineering support for research facilities; miscellaneous engineering services, studies, and developments; maintenance; and environmental science studies.

Instrumentation and Controls Division biennial progress report, September 1, 1976--September 1, 1978

International Nuclear Information System (INIS)

Sadowski, G.S.

1978-11-01

Progress is summarized in the following research and development areas: electronic circuits;instruments; radiation monitoring; process systems and instrumentation; thermometry; instrumentation for engineering experiments and test loops; HTGR fuel recycle development; reactor measurements and analysis; automatic control and data acquisition; electronic engineering support for research facilities; miscellaneous engineering services, studies, and developments; maintenance; and environmental science studies

Progress report on a fully automatic Gas Tungsten Arc Welding (GTAW) system development

Energy Technology Data Exchange (ETDEWEB)

Daumeyer, G.J. III

1994-12-01

A plan to develop a fully automatic gas tungsten arc welding (GTAW) system that will utilize a vision-sensing computer (which will provide in-process feedback control) is presently in work. Evaluations of different technological aspects and system design requirements continue. This report summaries major activities in the plan`s successful progress. The technological feasibility of producing the fully automated GTAW system has been proven. The goal of this process development project is to provide a production-ready system within the shortest reasonable time frame.

Developing test materials for dyscalculia

DEFF Research Database (Denmark)

Lindenskov, Lena; Bent, Lindhardt,

Aims, requirements and context for the development of test materials for dyscalculia are analyzed. The test materials are to be used for Grade 4 pupils in Danish primary schools. Preliminary results are presented from focus group interview with adolescents and adults, who see themselves as being...

Comparison of Psychomotor Development Screening Test and Clinical Assessment of Psychomotor Development

Science.gov (United States)

Radmilović, Goranka; Matijević, Valentina; Zavoreo, Iris

2016-12-01

Numerous adverse factors are acting in the prenatal, perinatal and postnatal period of life and may be the cause of later mild or severe deviations from normal psychomotor development. Therefore, it is crucial to identify infants with neurological risk factors and infants that already have a delay from orderly development, in order to immediately initiate the rehabilitation process. The aim of this study was to determine whether there is difference in the assessment of psychomotor development in neurological risk children based on the psychomotor development test (Croatian, Razvoj psihomotorike, RPM test) and clinical evaluation of neuromotor development. RPM test is designed for rough estimate of psychomotor development in children in the first two years of life. The study included 15 full term children (8 male and 7 female) with clinical diagnosis of mild paraparesis and mild deviation from normal psychological and social development, and 15 full term children (8 male and 7 female) without neurological risk factors and deviations from normal psychomotor development, all at the age of 12-24 months. Of the 15 children diagnosed with mild paraparesis, none had delayed psychomotor development, 6.7% had suspect development and 93.3% had normal development on RPM test. All children in the control group had normal development on RPM test. According to the results, the RPM test is not sensitive enough to detect mild neurodevelopmental disorders.

Does the level of physical activity in university students influence development and progression of myopia? - A 2-year prospective cohort study

DEFF Research Database (Denmark)

Jacobsen, Niels; Jensen, Hanne; Goldschmidt, E.

2008-01-01

PURPOSE. To study whether physical activity has a protective effect on the development and progression of myopia in medical students. METHODS. In a 2-year longitudinal cohort study, 156 Caucasian first-year medical students from the University of Copenhagen were enrolled. The baseline examination...... with a refractive change toward myopia, whereas physical activity was inversely associated with a refractive change toward myopia (P = 0.015). Myopic eyes progressed significantly more than did emmetropic and hyperopic eyes (P = 0.002). CONCLUSIONS. An association between physical activity and myopia was observed......, suggesting a protective effect of physical activity on the development and progression of myopia in university students. The results confirm that intensive studying is a risk factor of myopia and that myopic progression or development is more likely in medical students in their early 20s than in their late...

Progress in the blood supply of Afghanistan.

Science.gov (United States)

Riley, William J; McCullough, Terri Konstenius; Rhamani, Ahmad Masoud; McCullough, Jeffrey

2017-07-01

The blood supply system in Afghanistan was badly damaged by years of conflict. In 2009, the Afghanistan National Blood Safety and Transfusion Service (ANBSTS) was established. For 6 years, we collaborated to assist with policy and infrastructure development; blood bank operations; blood collection, testing, and component production; transfusion practices; and training of technicians, nurses, midwives, and physicians. Policies were established, infrastructure was strengthened, and capable staff was acquired and trained. Standard operating procedures were developed, testing was improved, and quality systems were established. Thirty trainings were held for blood center staff. Four additional formal trainings were held for 39 physicians, 36 nurses and/or midwives, and 38 laboratory technicians. During 5 years of this project, blood collection increased by 40%. The ANBSTS has made impressive progress developing infrastructure, personnel, procedures, quality systems, and training programs and increasing blood collection. Knowledge of transfusion medicine was improved through structured training. © 2017 AABB.

Pakistan and the Millennium Development Goals for Maternal and Child Health: progress and the way forward.

Science.gov (United States)

Rizvi, Arjumand; Bhatti, Zaid; Das, Jai K; Bhutta, Zulfiqar A

2015-01-01

The world has made substantial progress in reducing maternal and child mortality, but many countries are projected to fall short of achieving their Millennium Development Goals (MDGs) 4 and 5 targets. The major objective of this paper is to examine progress in Pakistan in reducing maternal and child mortality and malnutrition over the last two decades. Data from recent national and international surveys suggest that Pakistan lags behind on all of its MDGs related to maternal and child health and, for some indicators especially related to nutrition, the situation has worsened from the baseline of 1990. Progress in addressing key social determinants such as poverty, female education and empowerment has also been slow and unregulated population growth has further compromised progress. There is a need to integrate the various different sectors and programmes to achieve the desired results effectively and efficiently as many of the determinants and influencing factors are outside the health sector.

Development of Deterministic and Probabilistic Fracture Mechanics Analysis Code PROFAS-RV for Reactor Pressure Vessel - Progress of the Work

Energy Technology Data Exchange (ETDEWEB)

Kim, Jong Min; Lee, Bong Sang [KAERI, Daejeon (Korea, Republic of)

2016-05-15

In this study, a deterministic/probabilistic fracture mechanics analysis program for reactor pressure vessel, PROFAS-RV, is developed. This program can evaluate failure probability of RPV using recent radiation embrittlement model of 10CFR50.61a and stress intensity factor calculation method of RCC-MRx code as well as the required basic functions of PFM program. Applications of some new radiation embrittlement model, material database, calculation method of stress intensity factors, and others which can improve fracture mechanics assessment of RPV are introduced. The purpose of this study is to develop a probabilistic fracture mechanics (PFM) analysis program for RPV considering above modification and application of newly developed models and calculation methods. In this paper, it deals with the development progress of the PFM analysis program for RPV, PROFAS-RV. The PROFAS-RV is being tested with other codes, and it is expected to revise and upgrade by reflecting the latest model and calculation method continuously. These efforts can minimize the uncertainty of the integrity evaluation for the reactor pressure vessel.

Progress report on fast breeder reactor development in Japan

International Nuclear Information System (INIS)

1980-01-01

The performance test on the reactor power increase to 75 MW was started on July 3, and the target of 75 MW was reached on July 16, in the experimental fast reactor Joyo. The tests on the heat transport characteristics, power coefficient, the response to the change of outlet temperature, the loss of external power supply and so on were carried out, and the performance test was finished on August 23, except the test of 75 MW continuous operation. The annual inspection of the systems is being carried out in parallel with the regular inspection. The design to prepare for the manufacture of the prototype fast reactor Monju is being prepared. The analysis of decay heat removal is being carried out, and various calculation codes were developed. The technological survey on overseas LMFBRs is being made. The conceptual design of the demonstration reactor is being prepared. The research and development of reactor physics, structural components for Joyo and Monju, instrumentation and control, sodium technology, fuel materials, structural materials, safety problems and steam generators are reported. The tests on the transient boiling of sodium, fuel failure propagation, heat transfer between molten materials, post-accident decay heat removal and so on have been carried out. (Kako, I.)

Progress in fusion technology at SWIP

Energy Technology Data Exchange (ETDEWEB)

Duan, X.R., E-mail: duanxr@swip.ac.cn; Chen, J.M.; Feng, K.M.; Liu, X.; Li, B.; Wu, J.H.; Wang, X.Y.; Zheng, P.F.; Wang, Y.Q.; Wang, P.H.; Liu, Yong

2016-11-01

Highlights: • Dispersion strengthened CLF-1 steel, vanadium alloys and tungsten alloys are developed. • The HCCB TBM conceptual design, development of functional materials such as Li{sub 4}SiO{sub 4} pebbles and Be pebbles are in progress. • A full size prototype shield block has been fabricated and passed ITER qualification. • Advanced divertor for a new tokamak are designed and analyzed. • GIS and GDC have entered the engineering design phase. - Abstract: The fusion research activities at Southwestern Institute of Physics (SWIP) include the HL-2A & HL-2M tokamak programs, fusion reactor design and materials, along with key fusion technologies including R&D on ITER procurement packages. This paper presents the progress of fusion technology at SWIP, including the ITER first wall and blanket, Chinese helium cooled ceramic breeder test blanket module (HCCB–TBM) for ITER, gas injection system and gas discharge cleaning system, as well as the recent activities on reactor materials and R&D related to advanced divertor. The final design for ITER first wall and blanket shielding blocks allocated to SWIP have been completed, and were validated by recent tests. Major manufacturing technologies, such as forging, deep drilling, explosion bonding and deep laser welding, have been successfully demonstrated. Furthermore, the conceptual design of CN–HCCB–TBM has been completed, the related materials’ preparation, mock-up manufacturing and tests have been implemented. The tungsten divertor has been studied with various bonding and coating technologies. Meanwhile, highlights of functional material for TBM, oxides and carbides dispersion strengthened (ODS, CDS) reduced activation ferritic/martensitic (RAFM) steel, vanadium and tungsten alloys are also presented.

THE EFFECTS OF SINGLE LEG HOP PROGRESSION AND DOUBLE LEGS HOP PROGRESSION EXERCISE TO INCREASE SPEED AND EXPLOSIVE POWER OF LEG MUSCLE

Directory of Open Access Journals (Sweden)

Nining W. Kusnanik

2015-05-01

Full Text Available The main purpose of this study was to determine the effect of single leg hop progression and double legs hop progression exercise to increase speed and explosive power of leg muscles. Plyometric is one of the training methods that can increase explosive power. There are many models of plyometric training including single leg hop progression and double leg hop progression. This research was experimental using match subject design techniques. The subjects of this study were 39 students who joined basketball school club. There were 3 groups in this study: Group 1 were 13 students who given sin¬gle leg hop progression exercise, Group 2 were 13 students who given double legs hop progression exercise, Group 3 were 13 students who given conventional exercise. The data was collected during pre test and post test by testing 30m speed running and vertical jump. The data was analyzed using Analysis of Varians (Anova. It was found that there were significantly increased on speed and explosive power of leg muscles of Group 1 and Group 2. It can be stated that single leg hop progression exercise was more effective than double leg hop progression exercise. The recent findings supported the hypothesis that single leg hop progression and double legs hop progression exercise can increase speed and explosive power of leg muscles. These finding were supported by some previous studies (Singh, et al, 2011; Shallaby, H.K., 2010. The single leg hop progression is more effective than double legs hop progression. This finding was consistent with some previous evidences (McCurdy, et al, 2005; Makaruk et al, 2011.

Development of a Computerized Visual Search Test

Science.gov (United States)

Reid, Denise; Babani, Harsha; Jon, Eugenia

2009-01-01

Visual attention and visual search are the features of visual perception, essential for attending and scanning one's environment while engaging in daily occupations. This study describes the development of a novel web-based test of visual search. The development information including the format of the test will be described. The test was designed…

BWR core melt progression phenomena: Experimental analyses

International Nuclear Information System (INIS)

Ott, L.J.

1992-01-01

In the BWR Core Melt in Progression Phenomena Program, experimental results concerning severe fuel damage and core melt progression in BWR core geometry are used to evaluate existing models of the governing phenomena. These include control blade eutectic liquefaction and the subsequent relocation and attack on the channel box structure; oxidation heating and hydrogen generation; Zircaloy melting and relocation; and the continuing oxidation of zirconium with metallic blockage formation. Integral data have been obtained from the BWR DF-4 experiment in the ACRR and from BWR tests in the German CORA exreactor fuel-damage test facility. Additional integral data will be obtained from new CORA BWR test, the full-length FLHT-6 BWR test in the NRU test reactor, and the new program of exreactor experiments at Sandia National Laboratories (SNL) on metallic melt relocation and blockage formation. an essential part of this activity is interpretation and use of the results of the BWR tests. The Oak Ridge National Laboratory (ORNL) has developed experiment-specific models for analysis of the BWR experiments; to date, these models have permitted far more precise analyses of the conditions in these experiments than has previously been available. These analyses have provided a basis for more accurate interpretation of the phenomena that the experiments are intended to investigate. The results of posttest analyses of BWR experiments are discussed and significant findings from these analyses are explained. The ORNL control blade/canister models with materials interaction, relocation and blockage models are currently being implemented in SCDAP/RELAP5 as an optional structural component

Test Driven Development: Performing Art

Science.gov (United States)

Bache, Emily

The art of Test Driven Development (TDD) is a skill that needs to be learnt, and which needs time and practice to master. In this workshop a select number of conference participants with considerable skill and experience are invited to perform code katas [1]. The aim is for them to demonstrate excellence and the use of Test Driven Development, and result in some high quality code. This would be for the benefit of the many programmers attending the conference, who could come along and witness high quality code being written using TDD, and get a chance to ask questions and provide feedback.

"Rekindle and Recapture the Love": Establishing System-Wide Indicators of Progress in Community Engagement and Economic Development

Science.gov (United States)

Janke, Emily M.

2014-01-01

In May 2012, University of North Carolina (UNC) President Tom Ross simultaneously commissioned two task forces to develop indicators that all UNC campuses could use to measure "progress in community engagement and economic development." The charge to the Community Engagement Task Force and the Economic Development Task Force was to…

The Community's research and development programme on decommissioning of nuclear installations: First annual progress report (year 1985)

International Nuclear Information System (INIS)

1986-01-01

This is the first Annual Progress Report of the European Community's 1984-88 programme of research on the decommissioning of nuclear installations. It shows the status of implementation reached on 31 December 1985. The 1984-88 programme has the following contents: A. Research and development projects concerning the following subjects: Project No 1: Long-term integrity of building and systems; Project No 2: Decontamination for decommissioning purposes; Project No 3: Dismantling techniques; Project No 4: Treatment of specific waste materials: steel, concrete and graphite; Project No 5: Large containers for radioactive waste produced in the dismantling of nuclear installations; Project No 6: Estimation of the quantities of radioactive wastes arising from the decommissioning of nuclear installations in the Community; Project No 7: Influence of installation design features on decommissioning. B. Identification of guiding principles, namely: - certain guiding principles in the design and operation of nuclear installations with a view to simplifying their subsequent decommissioning, - guiding principles in the decommissioning of nuclear installations which could form the initial elements of a Community policy in this field. C. Testing of new techniques under real conditions, within the framework of large-scale decommissioning operations undertaken in Member States. This first progress report, covering the period of putting the programme into action, describes the work to be carried out under the 27 research contracts concluded, as well as initial work performed and first results obtained

The Audiovisual Vocational Preferences Test: A Research Note on Test Development.

Science.gov (United States)

Wilgosh, Lorraine

1992-01-01

This paper reports on the development of the Audiovisual Vocational Preferences Test to facilitate career planning for adolescents and young adults with mild to moderate intellectual impairments. The strategies involved in test construction, data on initial use of the test, and improvements in format and content after pilot testing are discussed.…

Progress Report on Alloy 617 Notched Specimen Testing

Energy Technology Data Exchange (ETDEWEB)

McMurtrey, Michael David [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wright, Richard Neil [Idaho National Lab. (INL), Idaho Falls, ID (United States); Lillo, Thomas Martin [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-08-01

Creep behavior of Alloy 617 has been extensively characterized to support the development of a draft Code Case to qualify Alloy 617 in Section III division 5 of the ASME Boiler and Pressure Vessel Code. This will allow use of Alloy 617 in construction of nuclear reactor components at elevated temperatures and longer periods of time (up to 950°C and 100,000 hours). Prior to actual use, additional concerns not considered in the ASME code need to be addressed. Code Cases are based largely on uniaxial testing of smooth gage specimens. In service conditions, components will generally be under multi axial loading. There is also the concern of the behavior at discontinuities, such as threaded components. To address the concerns of multi axial creep behavior and at geometric discontinuities, notched specimens have been designed to create conditions representative of the states that service components experience. Two general notch geometries have been used for these series of tests: U notch and V notch specimens. The notches produce a tri axial stress state, though not uniform across the specimen. Characterization of the creep behavior of the U notch specimens and the creep rupture behavior of the V notch specimens provides a good approximation of the behavior expected of actual components. Preliminary testing and analysis have been completed and are reported in this document. This includes results from V notch specimens tested at 900°C and 800°C. Failure occurred in the smooth gage section of the specimen rather than at the root of the notch, though some damage was present at the root of the notch, where initial stress was highest. This indicates notch strengthening behavior in this material at these temperatures.

Van de Graaff Laboratory progress report [for 1973

International Nuclear Information System (INIS)

Bhatia, M.S.

1975-01-01

Research and development activities of the Van de Graaff Laboratory of the Bhabha Atomic Research Centre, Bombay, during 1973 are reported. Brief account of the research experiments carried out with the 5.5 Mev and 400 kV Van de Graaff accelerator is given. A heavy ion source for ion implantation has been fabricated from indigenous raw materials. Progress and testing of its various components such as duo-plasmatron ion source, inverted motor, resistors, glass rings, stripper for 2 MV tandem accelerator, now under construction is reported. Various components for dual mass separator (DUMAS) are being fabricated and tested. (M.G.B.)

ABB’s Internationalization in the Emerging Chinese Market : Entry Mode and Market Development Progress

OpenAIRE

Phan Van, Thang; Xin, Zhang

2008-01-01

The aim of the thesis is to describe the entry mode choice and market development progress of the successful MNC ABB in the specific emerging market China. The authors also want to use theories in the master course of International Business and Entrepreneurship to explain the internationalization of one specific company ABB

Progress in development of MOSART concept with Th support

Energy Technology Data Exchange (ETDEWEB)

Ignatiev, V.; Feynberg, O.; Merzlyakov, A.; Surenkov, A.; Zagnitko, A. [National Research Center, Kurchatov Inst., Moscow (Russian Federation); Afonichkin, V.; Bovet, A.; Khokhlov, V. [Inst. of High Temperature Electrochemisty, Ekaterinburg (Russian Federation); Subbotin, V.; Fazilov, R.; Gordeev, M.; Panov, A.; Toropov, A. [Inst. of Technical Physics, Snezhinsk (Russian Federation)

2012-07-01

A study is under progress to examine the feasibility of Molten Salt Actinide Recycler and Transmuter system with U-Th support (MOSART+Th) fuelled with different compositions of actinide tri-fluorides (AnF{sub 3}) from used LWR fuel. New fast-spectrum design options with homogeneous core and fuel salt with high enough solubility for AnF{sub 3} are being examined because of new goals. Experimental data base created was used for further development of MOSART+Th technology as applied to consumption of AnF{sub 3} while extracting their energy. The flexibility of single fluid MOSART+Th concept fuel cycle is underlined, particularly, possibility of its operation in self-sustainable mode (CR=1) using different loadings and make up. The paper summarizes the current status of the design data for the MOSART+Th concept received within ISTC 3749 Task. (authors)

Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain.

Science.gov (United States)

Li, Wenwu; Sun, Guoqiang; Yang, Su; Qu, Qiuhao; Nakashima, Kinichi; Shi, Yanhong

2008-01-01

TLX is an orphan nuclear receptor that is expressed exclusively in vertebrate forebrains. Although TLX is known to be expressed in embryonic brains, the mechanism by which it influences neural development remains largely unknown. We show here that TLX is expressed specifically in periventricular neural stem cells in embryonic brains. Significant thinning of neocortex was observed in embryonic d 14.5 TLX-null brains with reduced nestin labeling and decreased cell proliferation in the germinal zone. Cell cycle analysis revealed both prolonged cell cycles and increased cell cycle exit in TLX-null embryonic brains. Increased expression of a cyclin-dependent kinase inhibitor p21 and decreased expression of cyclin D1 provide a molecular basis for the deficiency of cell cycle progression in embryonic brains of TLX-null mice. Furthermore, transient knockdown of TLX by in utero electroporation led to precocious cell cycle exit and differentiation of neural stem cells followed by outward migration. Together these results indicate that TLX plays an important role in neural development by regulating cell cycle progression and exit of neural stem cells in the developing brain.

Development and Validation of a Model to Determine Risk of Progression of Barrett's Esophagus to Neoplasia.

Science.gov (United States)

Parasa, Sravanthi; Vennalaganti, Sreekar; Gaddam, Srinivas; Vennalaganti, Prashanth; Young, Patrick; Gupta, Neil; Thota, Prashanthi; Cash, Brooks; Mathur, Sharad; Sampliner, Richard; Moawad, Fouad; Lieberman, David; Bansal, Ajay; Kennedy, Kevin F; Vargo, John; Falk, Gary; Spaander, Manon; Bruno, Marco; Sharma, Prateek

2018-04-01

A system is needed to determine the risk of patients with Barrett's esophagus for progression to high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). We developed and validated a model to determine of progression to HGD or EAC in patients with BE, based on demographic data and endoscopic and histologic findings at the time of index endoscopy. We performed a longitudinal study of patients with BE at 5 centers in United States and 1 center in Netherlands enrolled in the Barrett's Esophagus Study database from 1985 through 2014. Patients were excluded from the analysis if they had less than 1 year of follow-up, were diagnosed with HGD or EAC within the past year, were missing baseline histologic data, or had no intestinal metaplasia. Seventy percent of the patients were used to derive the model and 30% were used for the validation study. The primary outcome was development of HGD or EAC during the follow-up period (median, 5.9 years). Survival analysis was performed using the Kaplan-Meier method. We assigned a specific number of points to each BE risk factor, and point totals (scores) were used to create categories of low, intermediate, and high risk. We used Cox regression to compute hazard ratios and 95% confidence intervals to determine associations between risk of progression and scores. Of 4584 patients in the database, 2697 were included in our analysis (84.1% men; 87.6% Caucasian; mean age, 55.4 ± 20.1 years; mean body mass index, 27.9 ± 5.5 kg/m 2 ; mean length of BE, 3.7 ± 3.2 cm). During the follow-up period, 154 patients (5.7%) developed HGD or EAC, with an annual rate of progression of 0.95%. Male sex, smoking, length of BE, and baseline-confirmed low-grade dysplasia were significantly associated with progression. Scores assigned identified patients with BE that progressed to HGD or EAC with a c-statistic of 0.76 (95% confidence interval, 0.72-0.80; P Esophagus score) based on male sex, smoking, length of BE, and baseline low-grade dysplasia

Progression og underviserkompetencer

Directory of Open Access Journals (Sweden)

Lene Tortzen Bager

2014-03-01

Full Text Available På baggrund af en kvalitativ interviewundersøgelse af undervisere ved Aarhus Universitet lavet i 2012, tematiserer artiklen, hvordan undervisere udvikler deres faglige og pædagogiske kompetencer i forhold til at kunne skabe progression inden for innovation og entreprenørskab forstået enten som didaktik, arbejdsformer i faglige forløb eller som fag på universitetet. I arbejdet med progression er det en udfordring at integrere de nye faglige dimensioner i det kernefaglige felt. Den seneste model for progression inden for innovation og entreprenør-skab siger, at det er den lærendes generelle erfaringsniveau, der er den afgørende progressionsskabende faktor (Progressionsmodellen, Fonden for Entreprenørskab, 2013b. Samtidig skelner international forskning inden for studiekompetenceområdet mellem niveauer, hvor indlejret viden er det mest avancerede kompetenceniveau (Barrie, 2002.Ifølge progressionsmodellen og den nævnte kompetenceforskning er erfaring og dybt integreret læring altså centrale dimensioner i progression. Men hvad er underviserens rolle heri? Underviserens professionelle udviklingsarbejde forekommer at være underbelyst i forhold til, at underviseren er den legitime garant for integrationen af nye faglige dimensioner og for den studerendes kompetenceniveau. Interviewundersøgelsen forholder sig til spørgsmålet om progression gennem de deltagende underviseres beskrivelse af betydningslag i entreprenørskabsbegrebet koblet til de praksisformer i undervisningen, der knytter sig hertil samt et indblik i undervisernes refleksioner over deres kompetenceudviklingsprocesser. Artiklens bidrag til progression er at se underviserens motivation og kompetenceudvikling som forudsætninger herfor.     Based on a qualitative study of five teachers in the Faculty of Arts at Aarhus University that took place during 2012, the article thematizes how teachers develop their professional and educational qualifications in innovation and

The OSIRIS-REx laser altimeter (OLA): Development progress

Science.gov (United States)

Daly, M.; Barnouin, O.; Johnson, C.; Bierhaus, E.; Seabrook, J.; Dickinson, C.; Haltigin, T.; Gaudreau, D.; Brunet, C.; Cunningham, G.; Lauretta, D.; Boynton, W.; Beshore, E.

2014-07-01

will provide detailed information on the geological and geophysical processes which influence the surface regolith at scales relevant to the samples that will be collected. High resolution (meter-scale) spatial measurements of surface topographic slopes, center-of-mass referenced elevation, and vertical roughness within the sample ellipse will provide quantitative data on regolith processes such as surface granular flows that could have displaced the regolith sampled by OSIRIS-REx spacecraft. The OLA system will also be responsible for assessing hazards at any proposed sample site. Specifically, the OLA system will measure the slope distribution within the sample ellipse and characterize backscatter roughness at or below the scale of the OLA spot size. Technical Specifications: The completed OLA instrument is expected to achieve all these objectives through its specifications that are based on the characteristics of Bennu and operational considerations: Maximum Operational Range, 7.5 km; Minimum Operational Range, 0.150 km; Range Accuracy, 5--20 cm (range dependent); Range Resolution, <4 cm; Scanner Field of Regard, ±10 deg. (each axis); Laser Spot Size (on surface), 0.015--2 m (range dependent). Progress To-date: A prototype of the OLA system has been developed and successfully tested. Results from this testing will be presented and compared with the instrument requirements. Simulated OLA datasets will be presented along with the first engineering model hardware and test results.

Progressive multiple sclerosis, cognitive function, and quality of life.

Science.gov (United States)

Højsgaard Chow, Helene; Schreiber, Karen; Magyari, Melinda; Ammitzbøll, Cecilie; Börnsen, Lars; Romme Christensen, Jeppe; Ratzer, Rikke; Soelberg Sørensen, Per; Sellebjerg, Finn

2018-02-01

Patients with progressive multiple sclerosis (MS) often have cognitive impairment in addition to physical impairment. The burden of cognitive and physical impairment progresses over time, and may be major determinants of quality of life. The aim of this study was to assess to which degree quality of life correlates with physical and cognitive function in progressive MS. This is a retrospective study of 52 patients with primary progressive ( N  = 18) and secondary progressive MS ( N  = 34). Physical disability was assessed using the Expanded Disability Status Scale, Timed 25 Foot Walk (T25FW) test and 9-Hole Peg Test (9HPT). Cognitive function was assessed using Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test, and Trail Making Test B (TRAIL-B). In addition, quality of life was assessed by the Short Form 36 (SF-36) questionnaire. Only measures of cognitive function correlated with the overall SF-36 quality of life score and the Mental Component Summary score from the SF-36. The only physical measure that correlated with a measure of quality of life was T25FW test, which correlated with the Physical Component Summary from the SF-36. We found no other significant correlations between the measures of cognitive function and the overall physical measures but interestingly, we found a possible relationship between the 9HPT score for the nondominant hand and the SDMT and TRAIL-B. Our findings support inclusion of measures of cognitive function in the assessment of patients with progressive MS as these correlated closer with quality of life than measures of physical impairment.

State of the art in non-animal approaches for skin sensitization testing: from individual test methods towards testing strategies.

Science.gov (United States)

Ezendam, Janine; Braakhuis, Hedwig M; Vandebriel, Rob J

2016-12-01

The hazard assessment of skin sensitizers relies mainly on animal testing, but much progress is made in the development, validation and regulatory acceptance and implementation of non-animal predictive approaches. In this review, we provide an update on the available computational tools and animal-free test methods for the prediction of skin sensitization hazard. These individual test methods address mostly one mechanistic step of the process of skin sensitization induction. The adverse outcome pathway (AOP) for skin sensitization describes the key events (KEs) that lead to skin sensitization. In our review, we have clustered the available test methods according to the KE they inform: the molecular initiating event (MIE/KE1)-protein binding, KE2-keratinocyte activation, KE3-dendritic cell activation and KE4-T cell activation and proliferation. In recent years, most progress has been made in the development and validation of in vitro assays that address KE2 and KE3. No standardized in vitro assays for T cell activation are available; thus, KE4 cannot be measured in vitro. Three non-animal test methods, addressing either the MIE, KE2 or KE3, are accepted as OECD test guidelines, and this has accelerated the development of integrated or defined approaches for testing and assessment (e.g. testing strategies). The majority of these approaches are mechanism-based, since they combine results from multiple test methods and/or computational tools that address different KEs of the AOP to estimate skin sensitization potential and sometimes potency. Other approaches are based on statistical tools. Until now, eleven different testing strategies have been published, the majority using the same individual information sources. Our review shows that some of the defined approaches to testing and assessment are able to accurately predict skin sensitization hazard, sometimes even more accurate than the currently used animal test. A few defined approaches are developed to provide an

Progress towards a new Canadian irradiation-research facility

International Nuclear Information System (INIS)

Lee, A.G.; Lidstone, R.F.

1993-01-01

As reported at the second meeting of the International Group on Research Reactors, Atomic Energy of Canada Limited (AECL) is evaluating its options for future irradiation facilities. During the past year significant progress has been made towards achieving consensus on the irradiation requirements for AECL's major research programs and interpreting those requirements in terms of desirable characteristics for experimental facilities in a research reactor. The next stage of the study involves identifying near-term and long-term options for irradiation-research facilities to meet the requirements. The near-term options include assessing the availability of the NRU reactor and the capabilities of existing research reactors. The long-term options include developing a new irradiation-research facility by adapting the technology base for the MAPLE-X10 reactor design. Because materials testing in support of CANDU power reactors dominates AECL's irradiation requirements, the new reactor concept is called the MAPLE Materials Testing Reactor (MAPLE-MTR). Parametric physics and engineering studies are in progress on alternative MAPLE-MTR configurations to assess the capabilities for the following types of test facilities: - fast-neutron sites, that accommodate materials-irradiation assemblies, - small-diameter vertical fuel test loops that accommodate multielement assemblies, - large-diameter vertical fuel test loops, each able to hold one or more CANDU fuel bundles, - horizontal test loops, each able to hold full-size CANDU fuel bundles or small-diameter multi-element assemblies, and - horizontal beam tubes

Host microenvironment in breast cancer development: Inflammatory cells, cytokines and chemokines in breast cancer progression: reciprocal tumor–microenvironment interactions

International Nuclear Information System (INIS)

Ben-Baruch, A

2003-01-01

A comprehensive overview of breast cancer development and progression suggests that the process is influenced by intrinsic properties of the tumor cells, as well as by microenvironmental factors. Indeed, in breast carcinoma, an intensive interplay exists between the tumor cells on one hand, and inflammatory cells/cytokines/chemokines on the other. The purpose of the present review is to outline the reciprocal interactions that exist between these different elements, and to shed light on their potential involvement in breast cancer development and progression

Fuel Cell Development and Test Laboratory | Energy Systems Integration

Science.gov (United States)

Facility | NREL Fuel Cell Development and Test Laboratory Fuel Cell Development and Test Laboratory The Energy System Integration Facility's Fuel Cell Development and Test Laboratory supports fuel cell research and development projects through in-situ fuel cell testing. Photo of a researcher running

Recent progress and development of building vibration control systems in Japan

International Nuclear Information System (INIS)

Izumi, Masanori

1989-01-01

Japan is on a seismically active zone. The people are frequently shaken, and there is good reason to develop vibration control systems. Ministries and major construction companies have contributed to the progress of the technology. An example is the Fast Breeder Reactor (FBR) Research project, which may be equipped with a base-isolation system. Rubber bearings will be standardized and base-isolated buildings will be designed and constructed easily on good ground in the near future. But one needs time to realize a building with an active control system, which is effective in potentially destructive earthquakes

Waste Handling Equipment Development Test and Evaluation Study

International Nuclear Information System (INIS)

R.L. Tome

1998-01-01

The purpose of this study is to identify candidate Monitored Geologic Repository (MGR) surface waste handling equipment for development testing. This study will also identify strategies for performing the development tests. Development testing shall be implemented to support detail design and reduce design risks. Development testing shall be conducted to confirm design concepts, evaluate alternative design concepts, show the availability of needed technology, and provide design documentation. The candidate equipment will be selected from MGR surface waste handling equipment that is the responsibility of the Management and Operating Contractor (M and O) Surface Design Department. The equipment identified in this study is based on Viability Assessment (VA) design. The ''Monitored Geologic Repository Test and Evaluation Plan'' (MGR T and EP), Reference 5.1, was used as a basis for this study. The MGR T and EP reflects the extent of test planning and analysis that can be conducted, given the current status of the MGR requirements and latest VA design information. The MGR T and EP supports the appropriate sections in the license application (LA) in accordance with 10 CFR 60.2 1(c)(14). The MGR T and EP describes the following test activities: site characterization to confirm, by test and analysis, the suitability of the Yucca Mountain site for housing a geologic repository; development testing to investigate and document design concepts to reduce risk; qualification testing to verify equipment compliance with design requirements, specifications, and regulatory requirements; system testing to validate compliance with MGR requirements, which include the receipt, handling, retrieval, and disposal of waste; periodic performance testing to verify preclosure requirements and to demonstrate safe and reliable MGR operation; and performance confirmation modeling, testing, and analysis to verify adherence to postclosure regulatory requirements. Development test activities can be

Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64).

Science.gov (United States)

Adler, Amanda I; Stevens, Richard J; Manley, Sue E; Bilous, Rudy W; Cull, Carole A; Holman, Rury R

2003-01-01

The progression of nephropathy from diagnosis of type 2 diabetes has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma creatinine or renal replacement therapy (RRT), and death. Using observed and modeled data from 5097 subjects in the UK Prospective Diabetes Study, we measured the annual probability of transition from stage to stage (incidence), prevalence, cumulative incidence, ten-year survival, median duration per stage, and risk of death from all-causes or cardiovascular disease. From diagnosis of diabetes, progression to microalbuminuria occurred at 2.0% per year, from microalbuminuria to macroalbuminuria at 2.8% per year, and from macroalbuminuria to elevated plasma creatinine (>or=175 micromol/L) or renal replacement therapy at 2.3% per year. Ten years following diagnosis of diabetes, the prevalence of microalbuminuria was 24.9%, of macroalbuminuria was 5.3%, and of elevated plasma creatinine or RRT was 0.8%. Patients with elevated plasma creatinine or RRT had an annual death rate of 19.2% (95% confidence interval, CI, 14.0 to 24.4%). There was a trend for increasing risk of cardiovascular death with increasing nephropathy (P < 0.0001), with an annual rate of 0.7% for subjects in the stage of no nephropathy, 2.0% for those with microalbuminuria, 3.5% for those with macroalbuminuria, and 12.1% with elevated plasma creatinine or RRT. Individuals with macroalbuminuria were more likely to die in any year than to develop renal failure. The proportion of patients with type 2 diabetes who develop microalbuminuria is substantial with one quarter affected by 10 years from diagnosis. Relatively fewer patients develop macroalbuminuria, but in those who do, the death rate exceeds the rate of progression to worse nephropathy.

Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy

Directory of Open Access Journals (Sweden)

Juan C. Almagro

2018-01-01

Full Text Available The remarkable progress in engineering and clinical development of therapeutic antibodies in the last 40 years, after the seminal work by Köhler and Milstein, has led to the approval by the United States Food and Drug Administration (FDA of 21 antibodies for cancer immunotherapy. We review here these approved antibodies, with emphasis on the methods used for their discovery, engineering, and optimization for therapeutic settings. These methods include antibody engineering via chimerization and humanization of non-human antibodies, as well as selection and further optimization of fully human antibodies isolated from human antibody phage-displayed libraries and immunization of transgenic mice capable of generating human antibodies. These technology platforms have progressively led to the development of therapeutic antibodies with higher human content and, thus, less immunogenicity. We also discuss the genetic engineering approaches that have allowed isotype switching and Fc modifications to modulate effector functions and bioavailability (half-life, which together with the technologies for engineering the Fv fragment, have been pivotal in generating more efficacious and better tolerated therapeutic antibodies to treat cancer.

Gyrotron development at KIT: FULGOR test facility and gyrotron concepts for DEMO

Energy Technology Data Exchange (ETDEWEB)

Schmid, M., E-mail: martin.schmid@kit.edu [Institute for Pulsed Power and Microwave Technology (IHM), Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Franck, J.; Kalaria, P.; Avramidis, K.A.; Gantenbein, G.; Illy, S. [Institute for Pulsed Power and Microwave Technology (IHM), Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Jelonnek, J. [Institute for Pulsed Power and Microwave Technology (IHM), Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute of High Frequency Techniques and Electronics (IHE), Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Pagonakis, I. Gr.; Rzesnicki, T. [Institute for Pulsed Power and Microwave Technology (IHM), Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Thumm, M. [Institute for Pulsed Power and Microwave Technology (IHM), Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany); Institute of High Frequency Techniques and Electronics (IHE), Karlsruhe Institute of Technology, Association EURATOM-KIT, Karlsruhe (Germany)

2015-10-15

Highlights: • Substantial extension of the KIT gyrotron test facility FULGOR has started. • FULGOR will be able to test gyrotrons with continuous RF output power up to 4 MW. • Design of 240 GHz gyrotrons for efficient electron cyclotron current drive is progressing. • Output power of 240 GHz gyrotrons with conventional cavity up to 830 kW, with coaxial cavity up to 2 MW is feasible. • Multi-frequency operation with gyrotrons is also possible (170–267 GHz). - Abstract: At the Karlsruhe Institute of Technology (KIT), theoretical and experimental foundations for the development of future gyrotrons for fusion applications are being laid down. This includes the construction of the new Fusion Long Pulse Gyrotron Laboratory (FULGOR) test facility as well as physical design studies towards DEMO-compatible gyrotrons. Initially FULGOR will comprise of a 10 MW CW power supply, a 5 MW water cooling system (upgradeable to 10 MW), a superconducting 10 T magnet, one or two 2 MW ECRH test loads and a new control and data acquisition system for all these elements. The test facility will then be equipped to test the conventional 1 MW or coaxial 2 MW gyrotrons for DEMO, currently under design, as well as possible upgraded gyrotrons for W7-X and ITER. The design of the new high voltage DC power supply (HVDCPS) is flexible enough to handle gyrotrons with 4 MW CW output power (conceivably up to 170 GHz), but also test gyrotrons with higher frequencies (>250 GHz) which, due to physical limitations in the gyrotron design, will require less power but have more stringent demands on voltage stability.

Role of chymotrypsin C in development and progression of pancreatitis and pancreatic cancer

Directory of Open Access Journals (Sweden)

LIU Zejie

2016-11-01

Full Text Available Chymotrypsin C (CTRC is a trypsinogen synthesized by pancreatic acinar cells and secreted by pancreatic duct cells and belongs to the family of serine chymotrypsin. The main function of CTRC is to regulate the balance between activation and degradation of trypsin and maintain the structural and functional integrity of the pancreas. CTRC gene mutations can cause abnormal activation of trypsinogen and abnormal degradation of trypsin and then lead to the development of pancreatitis. The downregulation or absence of CTRC expression may be associated with the development and metastasis of pancreatic cancer. This article introduces the structure and biological function of CTRC and its mechanism of action in the development and progression of pancreatitis and pancreatic cancer.

Thermal-hydraulic tests with out-of-pile test facility for BOCA development

International Nuclear Information System (INIS)

Kitagishi, Shigeru; Aoyama, Masashi; Tobita, Masahiro; Inaba, Yoshitomo; Yamaura, Takayuki

2012-01-01

The fuel transient test facility was prepared for power ramping tests of light-water-reactor (LWR) fuels in the Japan Materials Testing Reactor (JMTR) under a contract project with the Nuclear Industrial Safety Agent (NISA) of the Ministry of Economy, Trade and Industry (METI). It is necessary to develop high accuracy analysis procedure for power ramping tests after restart of the JMTR. The out-of-pile test facility to simulate thermal-hydraulic conditions of the fuel transient test facility was therefore developed. Applicability of the analysis code ACE-3D was examined for thermal-hydraulic analysis of power ramping tests for 10x10 BWR fuels by the fuel transient test facility. As the results, the calculated temperature was 304°C in comparison with measured value of 304.9-317.4°C in the condition of 600 W/cm. There is a bright prospect of high accuracy power ramping tests by the fuel transient test facility in JMTR. (author)

Free-piston Stirling component test power converter test results and potential Stirling applications

Science.gov (United States)

Dochat, G. R.

1992-01-01

As the principal contractor to NASA-Lewis Research Center, Mechanical Technology Incorporated is under contract to develop free-piston Stirling power converters in the context of the competitive multiyear Space Stirling Technology Program. The first generation Stirling power converter, the component test power converter (CTPC) initiated cold end testing in 1991, with hot testing scheduled for summer of 1992. This paper reviews the test progress of the CTPC and discusses the potential of Stirling technology for various potential missions at given point designs of 250 watts, 2500 watts, and 25,000 watts.

Status of the Flooding Fragility Testing Development

Energy Technology Data Exchange (ETDEWEB)

Pope, C. L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Savage, B. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bhandari, B. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kamerman, D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Muchmore, C. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Roberts, G. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Ryan, E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Suresh, S. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tahhan, A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wells, A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, C. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-06-01

This report provides an update on research addressing nuclear power plant component reliability under flooding conditions. The research includes use of the Component Flooding Evaluation Laboratory (CFEL) where individual components and component subassemblies will be tested to failure under various flooding conditions. The resulting component reliability data can then be incorporated with risk simulation strategies to provide a more thorough representation of overall plant risk. The CFEL development strategy consists of four interleaved phases. Phase 1 addresses design and application of CFEL with water rise and water spray capabilities allowing testing of passive and active components including fully electrified components. Phase 2 addresses research into wave generation techniques followed by the design and addition of the wave generation capability to CFEL. Phase 3 addresses methodology development activities including small scale component testing, development of full scale component testing protocol, and simulation techniques including Smoothed Particle Hydrodynamic (SPH) based computer codes. Phase 4 involves full scale component testing including work on full scale component testing in a surrogate CFEL testing apparatus.

Status of the Flooding Fragility Testing Development

International Nuclear Information System (INIS)

Pope, C. L.; Savage, B.; Bhandari, B.; Kamerman, D.; Muchmore, C.; Roberts, G.; Ryan, E.; Suresh, S.; Tahhan, A.; Wells, A.; Smith, C.

2016-01-01

This report provides an update on research addressing nuclear power plant component reliability under flooding conditions. The research includes use of the Component Flooding Evaluation Laboratory (CFEL) where individual components and component subassemblies will be tested to failure under various flooding conditions. The resulting component reliability data can then be incorporated with risk simulation strategies to provide a more thorough representation of overall plant risk. The CFEL development strategy consists of four interleaved phases. Phase 1 addresses design and application of CFEL with water rise and water spray capabilities allowing testing of passive and active components including fully electrified components. Phase 2 addresses research into wave generation techniques followed by the design and addition of the wave generation capability to CFEL. Phase 3 addresses methodology development activities including small scale component testing, development of full scale component testing protocol, and simulation techniques including Smoothed Particle Hydrodynamic (SPH) based computer codes. Phase 4 involves full scale component testing including work on full scale component testing in a surrogate CFEL testing apparatus.

Development of Dissolution Test Method for Drotaverine ...

African Journals Online (AJOL)

Development of Dissolution Test Method for Drotaverine ... Methods: Sink conditions, drug stability and specificity in different dissolution media were tested to optimize a dissolution test .... test by Prism 4.0 software, and differences between ...

Progress in the realization of the PRIMA neutral beam test facility

Science.gov (United States)

Toigo, V.; Boilson, D.; Bonicelli, T.; Piovan, R.; Hanada, M.; Chakraborty, A.; Agarici, G.; Antoni, V.; Baruah, U.; Bigi, M.; Chitarin, G.; Dal Bello, S.; Decamps, H.; Graceffa, J.; Kashiwagi, M.; Hemsworth, R.; Luchetta, A.; Marcuzzi, D.; Masiello, A.; Paolucci, F.; Pasqualotto, R.; Patel, H.; Pomaro, N.; Rotti, C.; Serianni, G.; Simon, M.; Singh, M.; Singh, N. P.; Svensson, L.; Tobari, H.; Watanabe, K.; Zaccaria, P.; Agostinetti, P.; Agostini, M.; Andreani, R.; Aprile, D.; Bandyopadhyay, M.; Barbisan, M.; Battistella, M.; Bettini, P.; Blatchford, P.; Boldrin, M.; Bonomo, F.; Bragulat, E.; Brombin, M.; Cavenago, M.; Chuilon, B.; Coniglio, A.; Croci, G.; Dalla Palma, M.; D'Arienzo, M.; Dave, R.; De Esch, H. P. L.; De Lorenzi, A.; De Muri, M.; Delogu, R.; Dhola, H.; Fantz, U.; Fellin, F.; Fellin, L.; Ferro, A.; Fiorentin, A.; Fonnesu, N.; Franzen, P.; Fröschle, M.; Gaio, E.; Gambetta, G.; Gomez, G.; Gnesotto, F.; Gorini, G.; Grando, L.; Gupta, V.; Gutierrez, D.; Hanke, S.; Hardie, C.; Heinemann, B.; Kojima, A.; Kraus, W.; Maeshima, T.; Maistrello, A.; Manduchi, G.; Marconato, N.; Mico, G.; Moreno, J. F.; Moresco, M.; Muraro, A.; Muvvala, V.; Nocentini, R.; Ocello, E.; Ochoa, S.; Parmar, D.; Patel, A.; Pavei, M.; Peruzzo, S.; Pilan, N.; Pilard, V.; Recchia, M.; Riedl, R.; Rizzolo, A.; Roopesh, G.; Rostagni, G.; Sandri, S.; Sartori, E.; Sonato, P.; Sottocornola, A.; Spagnolo, S.; Spolaore, M.; Taliercio, C.; Tardocchi, M.; Thakkar, A.; Umeda, N.; Valente, M.; Veltri, P.; Yadav, A.; Yamanaka, H.; Zamengo, A.; Zaniol, B.; Zanotto, L.; Zaupa, M.

2015-08-01

The ITER project requires additional heating by two neutral beam injectors, each accelerating to 1 MV a 40 A beam of negative deuterium ions, to deliver to the plasma a power of about 17 MW for one hour. As these requirements have never been experimentally met, it was recognized as necessary to setup a test facility, PRIMA (Padova Research on ITER Megavolt Accelerator), in Italy, including a full-size negative ion source, SPIDER, and a prototype of the whole ITER injector, MITICA, aiming to develop the heating injectors to be installed in ITER. This realization is made with the main contribution of the European Union, through the Joint Undertaking for ITER (F4E), the ITER Organization and Consorzio RFX which hosts the Test Facility. The Japanese and the Indian ITER Domestic Agencies (JADA and INDA) participate in the PRIMA enterprise; European laboratories, such as IPP-Garching, KIT-Karlsruhe, CCFE-Culham, CEA-Cadarache and others are also cooperating. Presently, the assembly of SPIDER is on-going and the MITICA design is being completed. The paper gives a general overview of the test facility and of the status of development of the MITICA and SPIDER main components at this important stage of the overall development; then it focuses on the latest and most critical issues, regarding both physics and technology, describing the identified solutions.

Large animal models for vaccine development and testing.

Science.gov (United States)

Gerdts, Volker; Wilson, Heather L; Meurens, Francois; van Drunen Littel-van den Hurk, Sylvia; Wilson, Don; Walker, Stewart; Wheler, Colette; Townsend, Hugh; Potter, Andrew A

2015-01-01

The development of human vaccines continues to rely on the use of animals for research. Regulatory authorities require novel vaccine candidates to undergo preclinical assessment in animal models before being permitted to enter the clinical phase in human subjects. Substantial progress has been made in recent years in reducing and replacing the number of animals used for preclinical vaccine research through the use of bioinformatics and computational biology to design new vaccine candidates. However, the ultimate goal of a new vaccine is to instruct the immune system to elicit an effective immune response against the pathogen of interest, and no alternatives to live animal use currently exist for evaluation of this response. Studies identifying the mechanisms of immune protection; determining the optimal route and formulation of vaccines; establishing the duration and onset of immunity, as well as the safety and efficacy of new vaccines, must be performed in a living system. Importantly, no single animal model provides all the information required for advancing a new vaccine through the preclinical stage, and research over the last two decades has highlighted that large animals more accurately predict vaccine outcome in humans than do other models. Here we review the advantages and disadvantages of large animal models for human vaccine development and demonstrate that much of the success in bringing a new vaccine to market depends on choosing the most appropriate animal model for preclinical testing. © The Author 2015. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Genetics Home Reference: progressive external ophthalmoplegia

Science.gov (United States)

... and can affect both males and females, but fathers do not pass traits associated with changes in ... Genetic Testing (4 links) Genetic Testing Registry: Autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 1 ...

Power systems development facility. Quarterly technical progress report, January 1, 1994--March 31, 1994

Energy Technology Data Exchange (ETDEWEB)

1994-07-01

This quarterly technical progress report summarizes work completed during the last quarter of the Second Budget Period, January 1 through March 31, 1994, entitled {open_quotes}Hot Gas Cleanup Test Facility for Gasification and Pressurized Combustion.{close_quotes} The objective of this project is to evaluate hot gas particulate control technologies using coal-derived gas streams. This will entail the design, construction, installation, and use of a flexible test facility which can operate under realistic gasification and combustion conditions. The major particulate control device issues to be addressed include the integration of the particulate control devices into coal utilization systems, on-line cleaning techniques, chemical and thermal degradation of components, fatigue or structural failures, blinding, collection efficiency as a function of particle size, and scale-up of particulate control systems to commercial size.

FY2014 Vehicle and Systems Simulation and Testing Annual Progress Report

Energy Technology Data Exchange (ETDEWEB)

None

2015-03-01

The Vehicle and Systems Simulation and Testing research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to advancing light-, medium-, and heavy-duty vehicle systems to help maximize the number of electric miles driven and increase the energy efficiency of transportation vehicles.

Sequential Progressions in a Theory of Mind Scale: Longitudinal Perspectives

Science.gov (United States)

Wellman, Henry M.; Fuxi, Fang; Peterson, Candida C.

2011-01-01

Consecutive re-testings of 92 U.S. preschoolers (n = 30), Chinese preschoolers (n = 31), and deaf children (n = 31) examined whether the sequences of development apparent in cross-sectional results with a theory-of-mind scale also appeared in longitudinal assessment. Longitudinal data confirmed that theory-of-mind progressions apparent in cross-sectional scaling data also characterized longitudinal sequences of understanding for individual children. The match between cross-sectional and longitudinal sequences appeared for children who exhibit different progressions across cultures (U.S. vs. China) and for children with substantial delays (deaf children of hearing parents). Moreover, greater scale distances reflected larger longitudinal age differences. PMID:21428982

Chemistry research and development progress report, May-October, 1978

International Nuclear Information System (INIS)

Miner, F.J.

1979-01-01

Work in progress includes: calorimetry and thermodynamics of nuclear materials; americium recovery and purification; optimization of the cation exchange process for recovering americium and plutonium from molten salt extraction residues, photochemical separations of actinides; advanced ion exchange materials and techniques; secondary actinide recovery; removal of plutonium from lathe coolant oil; evaluation of tributyl phosphate-impregnated sorbent for plutonium-uranium separations; plutonium recovery in advance size reduction facility; plutonium peroxide precipitation; decontamination of Rocky Flats soil; soil decontamination at other Department of Energy sites; recovery of actinides from combustible wastes; induction-heated, tilt-pour furnace; vacuum melting; determination of plutonium and americium in salts and alloys by calorimetry; plutonium peroxide precipitation process; silica removal study; a comparative study of annular and Raschig ring-filled tanks; recovery of plutonium and americium from a salt cleanup alloy; and process development for recovery of americium from vacuum melt furnace crucibles

Development and validation of OECD test guidelines on mollusc reproductive toxicity tests

DEFF Research Database (Denmark)

Lagadic, Laurent; Holbech, Henrik; hutchinson, tom

the comparison of endpoints relevant for reproduction in invertebrates often shows a much higher sensitivity in molluscs vs. e.g. daphnids. The OECD test guideline programme has thus been extended to cover reproduction effects of chemicals in molluscs. Existing mollusc toxicity test protocols have been reviewed...... in an OECD Detailed Review Paper that identifies two relevant candidate species for developing freshwater tests: Potamopyrgus antipodarum and Lymnaea stagnalis. However, this review did not clarify which toxicity test design/conditions are the most appropriate for chemicals assessment. Therefore, a mollusc...... reproduction test guideline will be developed describing partial- and full- life-cycle test protocols in these species, so as to propose a balanced suite of apical mollusc toxicity tests applicable for the assessment of any type of chemical, including endocrine disruptors, as level 4 and 5 assays of the EDTA...

Assessment of regional progression of pulmonary emphysema with CT densitometry

DEFF Research Database (Denmark)

Bakker, M Els; Putter, Hein; Stolk, Jan

2008-01-01

BACKGROUND: Lung densitometry is an effective method to assess overall progression of emphysema, but generally the location of the progression is not estimated. We hypothesized that progression of emphysema is the result of extension from affected areas toward less affected areas in the lung....... To test this hypothesis, a method was developed to assess emphysema severity at different levels in the lungs in order to estimate regional changes. METHODS: Fifty subjects with emphysema due to alpha(1)-antitrypsin deficiency (AATD) [AATD deficiency of phenotype PiZZ (PiZ) group] and 16 subjects...... with general emphysema (general emphysema without phenotype PiZZ [non-PiZ] group) were scanned with CT at baseline and after 30 months. Densitometry was performed in 12 axial partitions of equal volumes. To indicate predominant location, craniocaudal locality was defined as the slope in the plot of densities...

Distribution of cadmium among geochemical fractions in floodplain soils of progressing development

International Nuclear Information System (INIS)

Lair, G.J.; Graf, M.; Zehetner, F.; Gerzabek, M.H.

2008-01-01

Initial soil development in river floodplains influences soil properties and processes. In this study, suites of young floodplain soils sampled at three European rivers (Danube/Austria, Ebro/Spain and Elbe/Germany) were used to link soil development to the soils' retention capacity for cadmium. Geochemichal fractionation of original and metal-spiked soils was conducted. Cadmium remained in weakly bound fractions in both original and spiked soils, representing an entirely different behaviour than observed for copper in an earlier study. The tendency of incorporation into more stable forms over time was only slightly expressed. Correlation analysis revealed the involvement of different sorption surfaces in soil, with no single soil constituent determining cadmium retention behaviour. Nevertheless, in the calcareous soils of the Danube floodplain, we found increased cadmium retention and decreased portions of desorbable cadmium with progressing soil development. - Distribution of cadmium among geochemical fractions in floodplain soils reveals high mobility but increased retention capacity with increasing soil age and development

Recent developments in dynamic testing of materials

Directory of Open Access Journals (Sweden)

Gilat Amos

2015-01-01

Full Text Available New techniques for dynamic characterization of materials that have been developed in the last three years (since the last DYMAT conference in 2012, and results from recent dynamic testing of Inconel 718 are presented. The first development is a dynamic punch test in which three dimensional Digital Image Correlation (DIC is used to measure the deformation of the rear surface of a specimen as it being penetrated. The second experimental technique that is under development is a dynamic tension experiment in which full-field strain measurement with DIC and full-field temperature measurement are done simultaneously during the test.

The Role of DNA Methylation in the Development and Progression of Lung Adenocarcinoma

Directory of Open Access Journals (Sweden)

Keith M. Kerr

2007-01-01

Full Text Available Lung cancer, caused by smoking in ∼87% of cases, is the leading cause of cancer death in the United States and Western Europe. Adenocarcinoma is now the most common type of lung cancer in men and women in the United States, and the histological subtype most frequently seen in never-smokers and former smokers. The increasing frequency of adenocarcinoma, which occurs more peripherally in the lung, is thought to be at least partially related to modifications in cigarette manufacturing that have led to a change in the depth of smoke inhalation. The rising incidence of lung adenocarcinoma and its lethal nature underline the importance of understanding the development and progression of this disease. Alterations in DNA methylation are recognized as key epigenetic changes in cancer, contributing to chromosomal instability through global hypomethylation, and aberrant gene expression through alterations in the methylation levels at promoter CpG islands. The identification of sequential changes in DNA methylation during progression and metastasis of lung adenocarcinoma, and the elucidation of their interplay with genetic changes, will broaden our molecular understanding of this disease, providing insights that may be applicable to the development of targeted drugs, as well as powerful markers for early detection and patient classification.

Biomedical Progress Rates as New Parameters for Models of Economic Growth in Developed Countries

Directory of Open Access Journals (Sweden)

Alex Zhavoronkov

2013-11-01

Full Text Available While the doubling of life expectancy in developed countries during the 20th century can be attributed mostly to decreases in child mortality, the trillions of dollars spent on biomedical research by governments, foundations and corporations over the past sixty years are also yielding longevity dividends in both working and retired population. Biomedical progress will likely increase the healthy productive lifespan and the number of years of government support in the old age. In this paper we introduce several new parameters that can be applied to established models of economic growth: the biomedical progress rate, the rate of clinical adoption and the rate of change in retirement age. The biomedical progress rate is comprised of the rejuvenation rate (extending the productive lifespan and the non-rejuvenating rate (extending the lifespan beyond the age at which the net contribution to the economy becomes negative. While staying within the neoclassical economics framework and extending the overlapping generations (OLG growth model and assumptions from the life cycle theory of saving behavior, we provide an example of the relations between these new parameters in the context of demographics, labor, households and the firm.

Biomedical progress rates as new parameters for models of economic growth in developed countries.

Science.gov (United States)

Zhavoronkov, Alex; Litovchenko, Maria

2013-11-08

While the doubling of life expectancy in developed countries during the 20th century can be attributed mostly to decreases in child mortality, the trillions of dollars spent on biomedical research by governments, foundations and corporations over the past sixty years are also yielding longevity dividends in both working and retired population. Biomedical progress will likely increase the healthy productive lifespan and the number of years of government support in the old age. In this paper we introduce several new parameters that can be applied to established models of economic growth: the biomedical progress rate, the rate of clinical adoption and the rate of change in retirement age. The biomedical progress rate is comprised of the rejuvenation rate (extending the productive lifespan) and the non-rejuvenating rate (extending the lifespan beyond the age at which the net contribution to the economy becomes negative). While staying within the neoclassical economics framework and extending the overlapping generations (OLG) growth model and assumptions from the life cycle theory of saving behavior, we provide an example of the relations between these new parameters in the context of demographics, labor, households and the firm.

New progressive technology of flat gears processing development

Directory of Open Access Journals (Sweden)

Михайло Володимирович Маргуліс

2015-11-01

Full Text Available Relevant scientific and technical problems in relation to mechanical engineering is development of new technological processes that make it possible to achieve high accuracy and durability of machine parts that meet the requirements imposed on them. So it is important to develop a new method to make a flat gear teeth by plastic deformation of the ingot. The article deals with the actual problem of improving productivity and quality of plane wheels teeth that are widely used in advanced wave, planetary and other transmissions. A progressive method to produce flat gear teeth gear by plastic deformation of the ingot with two knurl rollers alternately moving reciprocally in the direction not intersecting the axis of the ingot mounting surface has been described in the article. The working surface of the rollers corresponds to the resulting shape of the teeth. The schemes of the teeth installing and knurling have been shown. The necessary material and the heat treatment of the knurling tools have been described. Its use will significantly increase the wear resistance of the working surfaces of the teeth and their durability as well as to increase productivity and its manufacturing costs. The material of the rollers is BC15steel. The surface layer of the knurling tools was subjected to nitration, surface hardness being up to 65 HRC. Knurling is made in the5236P shaper suited for this purpose

Progress in CPI Microwave Tube Development

Science.gov (United States)

Wright, Edward L.; Bohlen, Heinz

2006-01-01

CPI continues its role as a leading supplier of state-of-the-art, high-power microwave tubes; from linear beam, velocity- and density-modulated devices, to high frequency gyro-devices. Klystrons are the device-of-choice for many high-power microwave applications, and can provide multi-megawatts to multi-kilowatts of power from UHF to W-band, respectively. A number of recent and on-going developments will be described. At UHF frequencies, the inductive output tube (IOT) has replaced the klystron for terrestrial NTSC and HDTV broadcast, due to its high efficiency and linearity, and is beginning to see use in scientific applications requiring 300 kW or less. Recent advances have enabled use well into L-band. CPI has developed a number of multiple-beam amplifiers. The VKL-8301 multiple-beam klystron (MBK) was built for the TESLA V/UV and x-ray FEL projects, and is a candidate RF source for the International Linear Collider (ILC). We have also contributed to the development of the U.S. Naval Research Laboratory (NRL) high-power fundamental-mode S-band MBK. The VHP-8330B multiple-beam, high-order mode (HOM) IOT shows great promise as a compact, CW UHF source for high power applications. These topics will be discussed, along with CPI's development capabilities for new and novel applications. Most important is our availability to provide design and fabrication services to organizations requiring CPI's manufacturing and process control infrastructure to build and test state-of-the-art devices.

LMFBR aerosol release and transport program. Quarterly progress report, July--September 1975

International Nuclear Information System (INIS)

Fontana, M.H.; Kress, T.S.; Adams, R.E.; Parsly, L.F.; Parker, G.W.

1976-04-01

Progress is summarized in the areas of capacitor discharge vaporizer (CDV) development, small-vessel fuel and fuel-simulant aerosol studies, large-vessel aerosol studies, HCDA bubble simulant tests, fuel-simulant response to CDV electrical energy deposition, bubble shape and rise behavior, and structural integrity of equipment cell liners

Chemical/Biological Agent Resistance Test (CBART) Test Fixture System Verification and Analytical Monitioring System Development

Science.gov (United States)

2011-03-15

progress was made towards the proportional intergral derivative (PID) tuning. The CBART NRT analytical system was developed, moved, replumbed, and...efficacy, or applicability of the contents hereof. The use of trade names in this report does not constitute endorsement of any commercial product ...Office MFC mass flow controller MS mass spectrometer MSD mass selective detector NRT near real-time PID proportional intergral derivative

Test Marketing in New Product Development

Science.gov (United States)

Klompmaker, Jay E.; And Others

1976-01-01

Discusses the role of test marketing in new product development, based on interviews with marketing executives. Attempts to clarify when a test market should be done, what its aims should be, and how it should be used. (JG)

Progress towards developing neutron tolerant magnetostrictive and piezoelectric transducers

Science.gov (United States)

Reinhardt, Brian; Tittmann, Bernhard; Rempe, Joy; Daw, Joshua; Kohse, Gordon; Carpenter, David; Ames, Michael; Ostrovsky, Yakov; Ramuhalli, Pradeep; Montgomery, Robert; Chien, Hualte; Wernsman, Bernard

2015-03-01

Current generation light water reactors (LWRs), sodium cooled fast reactors (SFRs), small modular reactors (SMRs), and next generation nuclear plants (NGNPs) produce harsh environments in and near the reactor core that can severely tax material performance and limit component operational life. To address this issue, several Department of Energy Office of Nuclear Energy (DOE-NE) research programs are evaluating the long duration irradiation performance of fuel and structural materials used in existing and new reactors. In order to maximize the amount of information obtained from Material Testing Reactor (MTR) irradiations, DOE is also funding development of enhanced instrumentation that will be able to obtain in-situ, real-time data on key material characteristics and properties, with unprecedented accuracy and resolution. Such data are required to validate new multi-scale, multi-physics modeling tools under development as part of a science-based, engineering driven approach to reactor development. It is not feasible to obtain high resolution/microscale data with the current state of instrumentation technology. However, ultrasound-based sensors offer the ability to obtain such data if it is demonstrated that these sensors and their associated transducers are resistant to high neutron flux, high gamma radiation, and high temperature. To address this need, the Advanced Test Reactor National Scientific User Facility (ATR-NSUF) is funding an irradiation, led by PSU, at the Massachusetts Institute of Technology Research Reactor to test the survivability of ultrasound transducers. As part of this effort, PSU and collaborators have designed, fabricated, and provided piezoelectric and magnetostrictive transducers that are optimized to perform in harsh, high flux, environments. Four piezoelectric transducers were fabricated with either aluminum nitride, zinc oxide, or bismuth titanate as the active element that were coupled to either Kovar or aluminum waveguides and two

Progress towards developing neutron tolerant magnetostrictive and piezoelectric transducers

Energy Technology Data Exchange (ETDEWEB)

Reinhardt, Brian; Tittmann, Bernhard [The Pennsylvania State University (United States); Rempe, Joy; Daw, Joshua [Idaho National Laboratory (United States); Kohse, Gordon; Carpenter, David; Ames, Michael; Ostrovsky, Yakov [Massachusetts Institute of Technology (United States); Ramuhalli, Pradeep; Montgomery, Robert [Pacific Northwest National Laboratory (United States); Chien, Hualte [Argonne National Laboratory (United States); Wernsman, Bernard [Bechtel Marine Propulsion Corp (United States)

2015-03-31

Current generation light water reactors (LWRs), sodium cooled fast reactors (SFRs), small modular reactors (SMRs), and next generation nuclear plants (NGNPs) produce harsh environments in and near the reactor core that can severely tax material performance and limit component operational life. To address this issue, several Department of Energy Office of Nuclear Energy (DOE-NE) research programs are evaluating the long duration irradiation performance of fuel and structural materials used in existing and new reactors. In order to maximize the amount of information obtained from Material Testing Reactor (MTR) irradiations, DOE is also funding development of enhanced instrumentation that will be able to obtain in-situ, real-time data on key material characteristics and properties, with unprecedented accuracy and resolution. Such data are required to validate new multi-scale, multi-physics modeling tools under development as part of a science-based, engineering driven approach to reactor development. It is not feasible to obtain high resolution/microscale data with the current state of instrumentation technology. However, ultrasound-based sensors offer the ability to obtain such data if it is demonstrated that these sensors and their associated transducers are resistant to high neutron flux, high gamma radiation, and high temperature. To address this need, the Advanced Test Reactor National Scientific User Facility (ATR-NSUF) is funding an irradiation, led by PSU, at the Massachusetts Institute of Technology Research Reactor to test the survivability of ultrasound transducers. As part of this effort, PSU and collaborators have designed, fabricated, and provided piezoelectric and magnetostrictive transducers that are optimized to perform in harsh, high flux, environments. Four piezoelectric transducers were fabricated with either aluminum nitride, zinc oxide, or bismuth titanate as the active element that were coupled to either Kovar or aluminum waveguides and two

Recent progress in safety-related applications of reactor noise analysis

International Nuclear Information System (INIS)

Hirota, Jitsuya; Shinohara, Yoshikuni; Saito, Keiichi

1982-01-01

Recent progress in safety-related applications of reactor noise analysis is reviewed, mainly referring to various papers presented at the Third Specialists' Meeting on Reactor Noise (SMORN-III) held in Tokyo in 1981. Advances in application of autoregressive model, coherence analysis and pattern recognition technique are significant since SMORN-II in 1977. Development of reactor diagnosis systems based on noise analysis is in progress. Practical experiences in the safety-related applications to power plants are being accumulated. Advances in quantitative monitoring of vibration of internal structures in PWR and diagnosis of core stability and control system characteristics in BWR are notable. Acoustic methods are also improved to detect sodium boiling in LMFBR. The Reactor Noise Analysis Benchmark Test performed by Japan in connection with SMORN-III is successful so that it is possible to proceed to the second stage of the benchmark test. (author)

ORNL Interim Progress Report on Static CIRFT Testing Curvature Data Update

Energy Technology Data Exchange (ETDEWEB)

Wang, Jy-An John [ORNL; Wang, Hong [ORNL

2016-10-10

Since the CIRFT tests reported in NUREG-7198 were generated, a number of factors that influence the recorded curvature measurement data were identified. In 2016, a data reanalysis task was undertaken to implement the lessons learned. This letter report provides the revised results of previous CIRFT tests, after implementing the following data reanalysis procedures: (A) experimental data smoothing and LVDT reset, (B) LVDT probe contact and sensor spacing correction for curvature data, and (C) LVDT probe dynamic vibration adjustment procedure development.

US NRC/LLL liaison with the Federal Republic of Germany for the GKSS-PSS steam condensation tests. Progress report No. 1

International Nuclear Information System (INIS)

McCauley, E.W.

1979-01-01

This progress report for the USNRC/LLL Liaison program with the Federal Republic of Germany regarding boiling water reactor containment multivent steam condensation tests being conducted by GKSS (Gesellschaft fuer Kernenergieverwertung in Schiffbau und Schiffahrt) address program activity during the period of May-June 1979. During this period the program scope was defined, initial contacts between LLL and GKSS were established, and the first trip by an LLL representative to the GKSS test facility was taken

Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons

DEFF Research Database (Denmark)

Kamara, David A; Nielsen, Lene Ryom; Ross, Michael

2014-01-01

No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glomerular filtration rate (eGFR) >90ml/min/1.73m2 (using Cockcroft Gault) in the Data...

Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas