WorldWideScience

Sample records for test candidate assessments

  1. A computer vision based candidate for functional balance test.

    Science.gov (United States)

    Nalci, Alican; Khodamoradi, Alireza; Balkan, Ozgur; Nahab, Fatta; Garudadri, Harinath

    2015-08-01

    Balance in humans is a motor skill based on complex multimodal sensing, processing and control. Ability to maintain balance in activities of daily living (ADL) is compromised due to aging, diseases, injuries and environmental factors. Center for Disease Control and Prevention (CDC) estimate of the costs of falls among older adults was $34 billion in 2013 and is expected to reach $54.9 billion in 2020. In this paper, we present a brief review of balance impairments followed by subjective and objective tools currently used in clinical settings for human balance assessment. We propose a novel computer vision (CV) based approach as a candidate for functional balance test. The test will take less than a minute to administer and expected to be objective, repeatable and highly discriminative in quantifying ability to maintain posture and balance. We present an informal study with preliminary data from 10 healthy volunteers, and compare performance with a balance assessment system called BTrackS Balance Assessment Board. Our results show high degree of correlation with BTrackS. The proposed system promises to be a good candidate for objective functional balance tests and warrants further investigations to assess validity in clinical settings, including acute care, long term care and assisted living care facilities. Our long term goals include non-intrusive approaches to assess balance competence during ADL in independent living environments.

  2. Ethical issues in the psychosocial assessment of bariatric surgery candidates.

    Science.gov (United States)

    Rouleau, Codie R; Rash, Joshua A; Mothersill, Kerry J

    2016-07-01

    Psychosocial evaluation is recommended prior to bariatric surgery. Practice guidelines have been published on assessment methods for bariatric surgery candidates, but they have not emphasized ethical issues with this population. This review outlines ethical and professional considerations for behavioral healthcare providers who conduct pre-surgical assessments of bariatric surgery candidates by merging ethical principles for mental health professionals with current practices in pre-surgical assessments. Issues discussed include the following: (a) establishing and maintaining competence, (b) obtaining informed consent, (c) respecting confidentiality, (d) avoiding bias and discrimination, (e) avoiding and addressing dual roles, (f) selecting and using psychological tests, and (g) acknowledging limitations of psychosocial assessments. © The Author(s) 2014.

  3. Multidimensional Aptitude Battery-Second Edition Intelligence Testing of Remotely Piloted Aircraft Training Candidates Compared with Manned Airframe Training Candidates

    Science.gov (United States)

    2015-03-01

    assessing the general intelligence and neuropsychological aptitudes of USAF RPA pilot training candidates. Chappelle et al. obtained comprehensive...computer-based intelligence testing (Multidimensional Aptitude Battery-Second Edition [MAB-II]) and neuropsychological screening (MicroCog) on USAF MQ-1... schizophrenia , attention deficit hyperactivity disorder, and autism spectrum disorders) and not on very high functioning populations such as aviators

  4. Candidates' Assessment of a Principal Preparation Program

    Science.gov (United States)

    Williams, Henry S.; Szal, Dennis

    2011-01-01

    The clear call for accountability has been heard throughout the country as it deals with the system of education in the United States. Students are expected to be accountable for their learning as measured by state or national tests. Teachers are held responsible for their students' learning. Colleges and Universities have not, and should not…

  5. Identifying and Assessing Dispositions of Educational Leadership Candidates

    Science.gov (United States)

    Melton, Teri; Mallory, Barbara J.; Green, James

    2010-01-01

    The purpose of this study was to identify educational leadership programs' procedures for the identification and assessment of leadership dispositions. The findings of this cross sectional survey indicated that there is little consistency in practice in defining and assessing dispositions of leadership candidates. While findings indicated that the…

  6. Tests of candidate materials for particle bed reactors

    International Nuclear Information System (INIS)

    Horn, F.L.; Powell, J.R.; Wales, D.

    1987-01-01

    Rhenium metal hot frits and zirconium carbide-coated fuel particles appear suitable for use in flowing hydrogen to at least 2000 K, based on previous tests. Recent tests on alternate candidate cooled particle and frit materials are described. Silicon carbide-coated particles began to react with rhenium frit material at 1600 K, forming a molten silicide at 2000 K. Silicon carbide was extensively attacked by hydrogen at 2066 K for 30 minutes, losing 3.25% of its weight. Vitrous carbon was also rapidly attacked by hydrogen at 2123 K, losing 10% of its weight in two minutes. Long term material tests on candidate materials for closed cycle helium cooled particle bed fuel elements are also described. Surface imperfections were found on the surface of pyrocarbon-coated fuel particles after ninety days exposure to flowing (∼500 ppM) impure helium at 1143 K. The imperfections were superficial and did not affect particle strength

  7. Assessment of potential solder candidates for high temperature applications

    DEFF Research Database (Denmark)

    pressure to eliminate lead containing materials despite the fact that materials for high Pb containing alloys are currently not affected by any legislations. A tentative assessment was carried out to determine the potential solder candidates for high temperature applications based on the solidification...... criterion, phases predicted in the bulk solder and the thermodynamic stability of chlorides. These promising solder candidates were precisely produced using the hot stage microscope and its respective anodic and cathodic polarization curves were investigated using a micro-electrochemical set up...

  8. Kernel Machine SNP-set Testing under Multiple Candidate Kernels

    Science.gov (United States)

    Wu, Michael C.; Maity, Arnab; Lee, Seunggeun; Simmons, Elizabeth M.; Harmon, Quaker E.; Lin, Xinyi; Engel, Stephanie M.; Molldrem, Jeffrey J.; Armistead, Paul M.

    2013-01-01

    Joint testing for the cumulative effect of multiple single nucleotide polymorphisms grouped on the basis of prior biological knowledge has become a popular and powerful strategy for the analysis of large scale genetic association studies. The kernel machine (KM) testing framework is a useful approach that has been proposed for testing associations between multiple genetic variants and many different types of complex traits by comparing pairwise similarity in phenotype between subjects to pairwise similarity in genotype, with similarity in genotype defined via a kernel function. An advantage of the KM framework is its flexibility: choosing different kernel functions allows for different assumptions concerning the underlying model and can allow for improved power. In practice, it is difficult to know which kernel to use a priori since this depends on the unknown underlying trait architecture and selecting the kernel which gives the lowest p-value can lead to inflated type I error. Therefore, we propose practical strategies for KM testing when multiple candidate kernels are present based on constructing composite kernels and based on efficient perturbation procedures. We demonstrate through simulations and real data applications that the procedures protect the type I error rate and can lead to substantially improved power over poor choices of kernels and only modest differences in power versus using the best candidate kernel. PMID:23471868

  9. FUNCTIONAL ASSESSMENT OF OLDER OBESE PATIENTS CANDIDATES FOR BARIATRIC SURGERY

    Directory of Open Access Journals (Sweden)

    Denis PAJECKI

    2014-03-01

    Full Text Available Context Obesity in the elderly is associated with exacerbation of functional decline (dependency, that occurs with aging, because of decreased muscle mass and strength, and increased joint dysfunction. Consequently, there is progressive loss of independence, autonomy, chronic pain and impaired quality of life. The weight loss can bring benefits in all these aspects, especially when accompanied by exercises. Elderly patients with morbid obesity may be submitted to surgical treatment, taking into account that the massive weight loss, eventually caused by bariatric surgery, may exacerbate the loss of muscle mass and nutritional complications that may bring harm to the overall health and quality of life of these patients. The functional assessment of elderly patients, candidates for bariatric surgery and the extent to which surgery can bring benefits to the patients, in the field of functionality, has still to be determined. Objective To describe profile functionality in obese elderly referred to a bariatric surgery program. Methods Patients with age ≥60 and BMI ≥35 underwent comprehensive geriatric assessment that evaluates co morbidities, medication use, ability to perform basic activities of daily living and instrumental activities of daily living, and the “Timedupandgo” test to evaluate mobility, whose cut-off point was ≤10 seconds. Statistical analysis was performed in order to see if there is a positive correlation of dependency with BMI and age (over or under 65 years. Results Forty subjects have completed evaluation. The mean age was 64.1 years (60-72 and 75% were women. They had an average weight of 121.1 kg (72.7-204 and a mean BMI of 47.2 kg/m2 (35.8-68.9. 16 patients (40% have shown dependency for activities of daily living, 19 (47,5% for instrumental activities of daily living and 20 patients (50% had a “Timedupandgo” test over 10 seconds. Statistical analysis (t-Student, Mann-Whitney, Binary Logistic Regression has shown

  10. Socially desirable responding by bariatric surgery candidates during psychological assessment.

    Science.gov (United States)

    Ambwani, Suman; Boeka, Abbe G; Brown, Joshua D; Byrne, T Karl; Budak, Amanda R; Sarwer, David B; Fabricatore, Anthony N; Morey, Leslie C; O'Neil, Patrick M

    2013-01-01

    Most bariatric surgery programs in the United States require preoperative psychological evaluations for candidates for surgery. Among those who perform these evaluations is concern that many patients engage in "impression management" or minimizing the symptoms of distress to receive a recommendation to proceed with surgery from the mental health professional. We sought to assess the prevalence of socially desirable responding and its associations with measures of psychological functioning among bariatric surgery candidates at 2 academic medical centers in the United States. The participants were male (n = 66) and female (n = 293) bariatric surgery candidates who presented for psychological evaluation. The participants completed 2 measures of socially desirable response styles (Marlowe-Crowne Social Desirability Scale and Personality Assessment Inventory Positive Impression Management scale) and standardized measures of anxiety, depression, and alcohol-related problems. The participants exhibited elevated scores on the social desirability indicators, with 33.3-39.8% scoring above the recommended cut-score on the Personality Assessment Inventory Positive Impression Management scale and 62.3-67% scoring 1 standard deviation above the standardization mean on the Marlowe-Crowne Social Desirability Scale. Scores on the Marlowe-Crowne Social Desirability Scale and Personality Assessment Inventory Positive Impression Management scale correlated inversely with the clinical measures of anxiety and depression, and the high/low scorers on the social desirability indices exhibited significant differences in anxiety and depression. Thus, elevated scores on the social desirability indices were associated with underreporting of certain clinical symptoms. A substantial proportion of bariatric surgery candidates appear to present themselves in an overly favorable light during the psychological evaluation. This response style is associated with less reporting of psychological

  11. Exercise Testing Reveals Everyday Physical Challenges of Bariatric Surgery Candidates.

    Science.gov (United States)

    Creel, David B; Schuh, Leslie M; Newton, Robert L; Stote, Joseph J; Cacucci, Brenda M

    2017-12-01

    Few studies have quantified cardiorespiratory fitness among individuals seeking bariatric surgery. Treadmill testing allows researchers to determine exercise capacity through metabolic equivalents. These findings can assist clinicians in understanding patients' capabilities to carry out various activities of daily living. The purpose of this study was to determine exercise tolerance and the variables associated with fitness, among individuals seeking bariatric surgery. Bariatric surgery candidates completed submaximal treadmill testing and provided ratings of perceived exertion. Each participant also completed questionnaires related to history of exercise, mood, and perceived barriers/benefits of exercise. Over half of participants reported that exercise was "hard to very hard" before reaching 70% of heart rate reserve, and one-third of participants reported that exercise was "moderately hard" at less than 3 metabolic equivalents (light activity). Body mass index and age accounted for the majority of the variance in exercise tolerance, but athletic history, employment status, and perceived health benefits also contributed. Perceived benefit scores were higher than barrier scores. Categories commonly used to describe moderate-intensity exercise (3-6 metabolic equivalents) do not coincide with perceptions of intensity among many bariatric surgery candidates, especially those with a body mass index of 50 or more.

  12. Psychological assessment of the adolescent bariatric surgery candidate.

    Science.gov (United States)

    Austin, Heather; Smith, Kevin; Ward, Wendy L

    2013-01-01

    Bariatric surgery for adolescents is an increasingly acceptable treatment option. However, research regarding who makes a successful candidate is limited. Although presurgical psychological assessment is deemed important before bariatric surgery, no formal standards of practice exist. The purpose of this paper is to provide further information and structure for successfully completing a comprehensive preoperative psychological assessment of the adolescent bariatric surgical patient. Contraindications and factors that affect adherence and postsurgical outcome are reviewed, incorporating available research and emerging standards of practice. Common recommendations for the adolescent (and family) after psychological assessment are also presented. Additional research and discussion regarding the psychological assessment of the adolescent bariatric surgery patient and the role of the psychologist on the multidisciplinary team is warranted. Copyright © 2013 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

  13. Lap Shear Testing of Candidate Radiator Panel Adhesives

    Science.gov (United States)

    Ellis, David; Briggs, Maxwell; McGowan, Randy

    2013-01-01

    During testing of a subscale radiator section used to develop manufacturing techniques for a full-scale radiator panel, the adhesive bonds between the titanium heat pipes and the aluminum face sheets failed during installation and operation. Analysis revealed that the thermal expansion mismatch between the two metals resulted in relatively large shear stresses being developed even when operating the radiator at moderate temperatures. Lap shear testing of the adhesive used in the original joints demonstrated that the two-part epoxy adhesive fell far short of the strength required. A literature review resulted in several candidate adhesives being selected for lap shear joint testing at room temperature and 398 K, the nominal radiator operating temperature. The results showed that two-part epoxies cured at room and elevated temperatures generally did not perform well. Epoxy film adhesives cured at elevated temperatures, on the other hand, did very well with most being sufficiently strong to cause yielding in the titanium sheet used for the joints. The use of an epoxy primer generally improved the strength of the joint. Based upon these results, a new adhesive was selected for the second subscale radiator section.

  14. Assessing pharmacologic and nonpharmacologic risks in candidates for kidney transplantation.

    Science.gov (United States)

    Maldonado, Angela Q; Tichy, Eric M; Rogers, Christin C; Campara, Maya; Ensor, Christopher; Doligalski, Christina T; Gabardi, Steven; Descourouez, Jillian L; Doyle, Ian C; Trofe-Clark, Jennifer

    2015-05-15

    Pharmacotherapy concerns and other factors with a bearing on patient selection for kidney transplantation are discussed. The process of selecting appropriate candidates for kidney transplantation involves multidisciplinary assessment to evaluate a patient's mental, social, physical, financial, and medical readiness for successful surgery and good posttransplantation outcomes. Transplantation pharmacists can play important roles in the recognition and stratification of pharmacologic and nonpharmacologic risks in prospective kidney transplant recipients and the identification of issues that require a mitigation strategy. Key pharmacotherapy-related issues and considerations during the risk assessment process include (1) anticoagulation concerns, (2) cytochrome P-450 isoenzyme-mediated drug interactions, (3) mental health-related medication use, (4) chronic pain-related medication use, (5) medication allergies, (6) use of hormonal contraception and replacement therapy, (7) prior or current use of immunosuppressants, (8) issues with drug absorption, (9) alcohol use, (10) tobacco use, (11) active use of illicit substances, and (12) use of herbal supplements. Important areas of nonpharmacologic risk include vaccine delivery, infection prophylaxis and treatment, and socially related factors such as nonadherent behavior, communication barriers, and financial, insurance, or transportation challenges that can compromise posttransplantation outcomes. Consensus opinions of practitioners in transplantation pharmacy regarding the pharmacologic and nonpharmacologic factors that should be considered in assessing candidates for kidney transplantation are presented. Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  15. The psychological assessment of candidates for reconstructive hand transplantation.

    Science.gov (United States)

    Kumnig, Martin; Jowsey, Sheila G; Rumpold, Gerhard; Weissenbacher, Annemarie; Hautz, Theresa; Engelhardt, Timm O; Brandacher, Gerald; Gabl, Markus; Ninkovic, Marina; Rieger, Michael; Zelger, Bernhard; Zelger, Bettina; Blauth, Michael; Margreiter, Raimund; Pierer, Gerhard; Pratschke, Johann; Schneeberger, Stefan

    2012-05-01

    Standardized psychological assessment of candidates for reconstructive hand transplantation (RHT) is a new approach in transplantation medicine. Currently, international guidelines and standardized criteria for the evaluation are not established. Patients suffering from the loss of a hand or an upper extremity have to cope with multiple challenges. For a selected group of patients, RHT represents an option for restoring natural function and for regaining daily living independence. The identification of at-risk patients and those requiring ongoing counseling due to poor coping or limited psychological resources are the primary focus of the psychological assessment. We have developed the 'Innsbruck Psychological Screening Program for Reconstructive Transplantation (iRT-PSP)' which utilizes a semi-structured interview and standardized psychological screening procedures and continuous follow-up ratings. Between January 2011 and October 2011, four candidates were evaluated using the iRT-PSP. Psychological impairments including social withdrawal, embarrassment, reduced self-esteem, and a depressive coping style were identified and poor quality of life was reported. The motivation for transplantation was diverse, depending on many factors such as bi- or unilateral impairment, native or accidental loss of hand, and social integration. © 2012 The Authors. Transplant International © 2012 European Society for Organ Transplantation.

  16. Assessment and Testing.

    Science.gov (United States)

    Clapham, Caroline

    2000-01-01

    Explores the term "applied linguistics" and discusses the role of language testing within this discipline, the relationship between testing and teaching, and the relationship between testing and assessment (Author/VWL)

  17. Cognitive Styles in Admission Procedures for Assessing Candidates of Architecture

    Science.gov (United States)

    Casakin, Hernan; Gigi, Ariela

    2016-01-01

    Cognitive style has a strong predictive power in academic and professional success. This study investigated the cognitive profile of candidates studying architecture. Specifically, it explored the relation between visual and verbal cognitive styles, and the performance of candidates in admission procedures. The cognitive styles of candidates who…

  18. Assessing Student Teaching Experiences: Teacher Candidates' Perceptions of Preparedness

    Science.gov (United States)

    Lee, Joohi; Tice, Kathleen; Collins, Denise; Brown, Amber; Smith, Cleta; Fox, Jill

    2012-01-01

    The purpose of this study is to investigate the effectiveness of student teaching experiences by measuring teacher candidates' perceptions of their preparedness. The participants were 130 teacher candidates who had completed their student teaching as part of a program preparing them to teach children in pre-K through grade 4. Teacher candidates…

  19. An objective framework to test the quality of candidate indicators of good environmental status

    Directory of Open Access Journals (Sweden)

    Ana M Queiros

    2016-05-01

    Full Text Available Large efforts are on-going within the EU to prepare the Marine Strategy Framework Directive’s (MSFD assessment of the environmental status of the European seas. This assessment will only be as good as the indicators chosen to monitor the eleven descriptors of good environmental status (GEnS. An objective and transparent framework to determine whether chosen indicators actually support the aims of this policy is, however, not yet in place. Such frameworks are needed to ensure that the limited resources available to this assessment optimize the likelihood of achieving GEnS within collaborating states. Here, we developed a hypothesis-based protocol to evaluate whether candidate indicators meet quality criteria explicit to the MSFD, which the assessment community aspires to. Eight quality criteria are distilled from existing initiatives, and a testing and scoring protocol for each of them is presented. We exemplify its application in three worked examples, covering indicators for three GEnS descriptors (1, 5 and 6, various habitat components (seaweeds, seagrasses, benthic macrofauna and plankton, and assessment regions (Danish, Lithuanian and UK waters. We argue that this framework provides a necessary, transparent and standardized structure to support the comparison of candidate indicators, and the decision-making process leading to indicator selection. Its application could help identify potential limitations in currently available candidate metrics and, in such cases, help focus the development of more adequate indicators. Use of such standardized approaches will facilitate the sharing of knowledge gained across the MSFD parties despite context-specificity across assessment regions, and support the evidence-based management of European seas.

  20. Assessment of PALB2 as a candidate melanoma susceptibility gene.

    Directory of Open Access Journals (Sweden)

    Lauren G Aoude

    Full Text Available Partner and localizer of BRCA2 (PALB2 interacts with BRCA2 to enable double strand break repair through homologous recombination. Similar to BRCA2, germline mutations in PALB2 have been shown to predispose to Fanconi anaemia as well as pancreatic and breast cancer. The PALB2/BRCA2 protein interaction, as well as the increased melanoma risk observed in families harbouring BRCA2 mutations, makes PALB2 a candidate for melanoma susceptibility. In order to assess PALB2 as a melanoma predisposition gene, we sequenced the entire protein-coding sequence of PALB2 in probands from 182 melanoma families lacking pathogenic mutations in known high penetrance melanoma susceptibility genes: CDKN2A, CDK4, and BAP1. In addition, we interrogated whole-genome and exome data from another 19 kindreds with a strong family history of melanoma for deleterious mutations in PALB2. Here we report a rare known deleterious PALB2 mutation (rs118203998 causing a premature truncation of the protein (p.Y1183X in an individual who had developed four different cancer types, including melanoma. Three other family members affected with melanoma did not carry the variant. Overall our data do not support a case for PALB2 being associated with melanoma predisposition.

  1. Identifying Canadian Teacher Candidates' Needs for Training in the Use of Inclusive Classroom Assessment

    Science.gov (United States)

    Lin, Pei-Ying; Lin, Yu-Cheng

    2015-01-01

    To identify teacher candidates' needs for training in inclusive classroom assessment, the present study investigated teacher candidates' beliefs about inclusive classroom assessments for all students educated in regular classrooms, including those with special needs and English language learners. An innovative theoretical assessment model,…

  2. A preliminary systems assessment of the Starlite Demo candidates

    International Nuclear Information System (INIS)

    Bathke, C.G.

    1995-01-01

    The Starlite project has evaluated the following five tokamaks as candidates for the US Demo Power Plant: (1) steady state, first stability regime; (2) pulsed, first stability regime; (3) steady state, second stability regime; (4) steady state, reversed shear; and (5) steady state, low aspect ratio. Systems analysis of these candidates has played an important role in the selection of a reversed-shear tokamak for further conceptual design as a US Demo Power Plant. The cost-based systems analysis that led to the selection of a reversed-shear tokamak is described herein

  3. Assessment of Educational Neuromyths among Teachers and Teacher Candidates

    Science.gov (United States)

    Canbulat, Tuncay; Kiriktas, Halit

    2017-01-01

    The aim of study is to determine the neuromyth level of teachers and pre-teachers and reveal if there is significant difference in terms of some variables (gender, class, etc.). Research was designed in survey model. The research sample was formed with 241 teachers and 511 teacher candidates. In the collection of data, "Educational neuromyths…

  4. TESTING IN SITU ASSEMBLY WITH THE KEPLER PLANET CANDIDATE SAMPLE

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, Brad M. S. [Department of Physics and Astronomy and Institute of Geophysics and Planetary Physics, University of California Los Angeles, Los Angeles, CA 90095 (United States); Murray, Norm, E-mail: hansen@astro.ucla.edu, E-mail: murray@cita.utoronto.ca [Canadian Institute for Theoretical Astrophysics, 60 St. George Street, University of Toronto, Toronto, ON M5S 3H8 (Canada)

    2013-09-20

    We present a Monte Carlo model for the structure of low-mass (total mass <25 M{sub ⊕}) planetary systems that form by the in situ gravitational assembly of planetary embryos into final planets. Our model includes distributions of mass, eccentricity, inclination, and period spacing that are based on the simulation of a disk of 20 M{sub ⊕}, forming planets around a solar-mass star, and assuming a power-law surface density distribution that drops with distance a as ∝ a {sup –1.5}. The output of the Monte Carlo model is then subjected to the selection effects that mimic the observations of a transiting planet search such as that performed by the Kepler satellite. The resulting comparison of the output to the properties of the observed sample yields an encouraging agreement in terms of the relative frequencies of multiple-planet systems and the distribution of the mutual inclinations when moderate tidal circularization is taken into account. The broad features of the period distribution and radius distribution can also be matched within this framework, although the model underpredicts the distribution of small period ratios. This likely indicates that some dissipation is still required in the formation process. The most striking deviation between the model and observations is in the ratio of single to multiple systems in that there are roughly 50% more single-planet candidates observed than are produced in any model population. This suggests that some systems must suffer additional attrition to reduce the number of planets or increase the range of inclinations.

  5. Corrosion Assessment of Candidate Materials for the SHINE Subcritical Assembly Vessel and Components FY15 Report

    Energy Technology Data Exchange (ETDEWEB)

    Pawel, Steven J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-01-01

    In the previous report of this series, a literature review was performed to assess the potential for substantial corrosion issues associated with the proposed SHINE process conditions to produce 99Mo. Following the initial review, substantial laboratory corrosion testing was performed emphasizing immersion and vapor-phase exposure of candidate alloys in a wide variety of solution chemistries and temperatures representative of potential exposure conditions. Stress corrosion cracking was not identified in any of the exposures up to 10 days at 80°C and 10 additional days at 93°C. Mechanical properties and specimen fracture face features resulting from slow-strain rate tests further supported a lack of sensitivity of these alloys to stress corrosion cracking. Fluid velocity was found not to be an important variable (0 to ~3 m/s) in the corrosion of candidate alloys at room temperature and 50°C. Uranium in solution was not found to adversely influence potential erosion-corrosion. Potentially intense radiolysis conditions slightly accelerated the general corrosion of candidate alloys, but no materials were observed to exhibit an annualized rate above 10 μm/y.

  6. Testing Gone Amok: Leave No Teacher Candidate behind

    Science.gov (United States)

    Wepner, Shelley B.

    2006-01-01

    Teacher preparation, now acknowledged for its impact on K-12 student achievement (Darling-Hammond, 2000; Darling-Hammond, Berry, & Thoreson, 2000), needs to be part of the discussions about ways to address emerging issues with testing and accountability. What then do teacher educators who work with those preparing to teach do to guide their…

  7. Testing the cosmological constant as a candidate for dark energy

    International Nuclear Information System (INIS)

    Kratochvil, Jan; Linde, Andrei; Linder, Eric V.; Shmakova, Marina

    2004-01-01

    It may be difficult to single out the best model of dark energy on the basis of the existing and planned cosmological observations, because many different models can lead to similar observational consequences. However, each particular model can be studied and either found consistent with observations or ruled out. In this paper, we concentrate on the possibility to test and rule out the simplest and by far the most popular of the models of dark energy, the theory described by general relativity with positive vacuum energy (the cosmological constant). We evaluate the conditions under which this model could be ruled out by the future observations made by the Supernova/Acceleration Probe SNAP (both for supernovae and weak lensing) and by the Planck Surveyor cosmic microwave background satellite

  8. Extended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine Candidate.

    Directory of Open Access Journals (Sweden)

    Kenneth S Plante

    Full Text Available We recently described a new, live-attenuated vaccine candidate for chikungunya (CHIK fever, CHIKV/IRES. This vaccine was shown to be well attenuated, immunogenic and efficacious in protecting against CHIK virus (CHIKV challenge of mice and nonhuman primates. To further evaluate its preclinical safety, we compared CHIKV/IRES distribution and viral loads in interferon-α/β receptor-incompetent A129 mice to another CHIK vaccine candidate, 181/clone25, which proved highly immunogenic but mildly reactive in human Phase I/II clinical trials. Compared to wild-type CHIK virus, (wt-CHIKV, both vaccines generated lower viral loads in a wide variety of tissues and organs, including the brain and leg muscle, but CHIKV/IRES exhibited marked restrictions in dissemination and viral loads compared to 181/clone25, and was never found outside the blood, spleen and muscle. Unlike wt-CHIKV, which caused disrupted splenic architecture and hepatic lesions, histopathological lesions were not observed in animals infected with either vaccine strain. To examine the stability of attenuation, both vaccines were passaged 5 times intracranially in infant A129 mice, then assessed for changes in virulence by comparing parental and passaged viruses for footpad swelling, weight stability and survival after subcutaneous infection. Whereas strain 181/clone25 p5 underwent a significant increase in virulence as measured by weight loss (from 30% and mortality (from 0 to 100%, CHIKV/IRES underwent no detectible change in any measure of virulence (no significant weight loss and no mortality. These data indicate greater nonclinical safety of the CHIKV/IRES vaccine candidate compared to 181/clone25, further supporting its eligibility for human testing.

  9. Pulmonary function tests in obese people candidate to bariatric surgery

    Directory of Open Access Journals (Sweden)

    C. Guimarães

    2012-05-01

    Full Text Available Obesity is considered one of the most serious public health problems of the modern world. Because it alters the relationship between the lungs, chest wall and diaphragm, it is to be expected that it impacts on the respiratory function. In Portugal, there is not much data about the relationship between obesity and pulmonary function.The aim of this study was to characterize respiratory function in morbidly obese patients and to evaluate whether weight loss in patients submitted to bariatric surgery affects pulmonary function tests (PFT.We conducted a retrospective study with 36 morbidly obese patients submitted to bariatric surgery, with a mean age of 40.6 years, 64% female and with a mean body mass index (BMI of 49.7 kg/m2. All patients were clinical and functionally evaluated before surgery and after their weight had stabilized following surgery. They underwent a complete pulmonary function testing with spirometry, lung volumes, carbon monoxide diffusing capacity (DLCO, maximum respiratory pressures and arterial blood gases analysis. Prior to surgery almost all the patients had functional respiratory changes, 34 had a decrease in functional residual capacity (FRC 6 of whom a restrictive syndrome. Only 2 patients did not show any functional or arterial blood gas change. After bariatric surgery, BMI decreased to 34 kg/m2 and there was a significant improvement in almost all functional parameters with resolution of restrictive disorders. Nevertheless, in 13 patients the FRC remained decreased.After weight loss, the only correlation found was between reduction of BMI and increased FRC (r = −0.371; p = 0.028. This study suggests a relationship between obesity and pulmonary restriction and a positive impact of bariatric surgery in PFT. Resumo: A obesidade é considerada um problema de saúde pública da atualidade. Devido ao facto de alterar a relação entre pulmões, parede torácica e diafragma, a obesidade tem

  10. Results of the ESA study on psychological selection of astronaut candidates for Columbus missions II: Personality assessment

    Science.gov (United States)

    Goeters, Klaus-Martin; Fassbender, Christoph

    A unique composition of personality assessment methods was applied to a group of 97 ESA scientists and engineers. This group is highly comparable to real astronaut candidates with respect to age and education. The list of used tests includes personality questionnaires, problem solving in groups as well as a projective technique. The study goals were: 1. Verification of psychometric qualities and applicability of tests to the target group; 2. Search for culture-fair tests by which multi-national European groups can be examined; 3. Identification of test methods by which the adaptability of the candidates to the psycho-social stress of long-duration space flights can be assessed. Based on the empirical findings, a test battery was defined which can be used in the selection of ESA space personnel.

  11. Assessment of the candidate markets for liquid boiler fuels

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-12-01

    Liquid fuels can be produced from coal in a number of indirect and direct liquefaction processes. While indirect coal liquefaction has been proved commercially outside the United States, most attention in this country has focused on the direct liquefaction processes, which include the processes under examination in this report; namely, the Exxon Donor Solvent (EDS), the H-Coal, and the Solvent Refined Coal (SRC) II processes. The objectives of the study were to: compare the boiler fuels of direct coal liquefaction with residual fuel oil (No. 6 fuel oil) including physical characteristics and environmental hazards, such as carcinogenic characteristics and toxic hazard characteristics; determine whether a boiler fuel market would exist for the coal liquefaction products given their physical characteristics and potential environmental hazards; determine the advantages of utilizing methanol as a boiler fuel on a continuous basis in commercial boilers utilizing existing technology; identify the potential regional candidate markets for direct coal liquefaction products as liquid boiler fuels; determine the distributing and handling costs associated with marketing coal liquefaction products as liquid boiler fuels; determine the current regulatory issues associated with the marketing of coal liquefaction products as boiler fuels; and determine and evaluate other institutional issues associated with the marketing of direct coal liquefaction products as boiler fuels.

  12. Assessment of Lactobacillus gasseri as a candidate oral vaccine vector.

    Science.gov (United States)

    Stoeker, Laura; Nordone, Shila; Gunderson, Sara; Zhang, Lin; Kajikawa, Akinobu; LaVoy, Alora; Miller, Michael; Klaenhammer, Todd R; Dean, Gregg A

    2011-11-01

    Lactobacillus species are commensal bacteria that have long been recognized as probiotic microbes and are generally regarded as safe (GRAS) for human consumption. We have investigated the use of L. gasseri as a vaccine vector for oral immunization against mucosal pathogens. Recent research has shown that the immune response to different lactobacilli can vary widely depending on the species or subspecies of Lactobacillus being studied. While some lactobacilli seem to induce oral tolerance, others induce an adaptive immune response. This study characterized the systemic and mucosal immune response to wild-type and genetically modified L. gasseri. L. gasseri primarily activates TLR2/6, with additional activation through the TLR2 homodimer. To expand the Toll-like receptor (TLR) activation profile of L. gasseri and the immunogenicity of the vector, a plasmid containing fliC, the gene encoding bacterial flagellin, was introduced which resulted in the strong activation of TLR5. The treatment of human myeloid dendritic cells with recombinant lactobacilli expressing flagellin triggered phenotypic maturation and the release of proinflammatory cytokines. In contrast, bacterial treatment also resulted in a statistically significant increase in IL-10 production. In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon. Furthermore, treatment with genetically modified L. gasseri led to a significant decrease in the percentage of FoxP3(+) colonic lymphocytes. Taken together, these data clarify the interaction of L. gasseri with the host immune system and support further investigation of the in vivo immunogenicity of L. gasseri expressing both flagellin and candidate vaccine antigens.

  13. ANALYZE THE KNOWLEDGE INQUIRY SCIENCE PHYSICS TEACHER CANDIDATES WITH ESSENCE INQUIRY SCIENCE TEST INSTRUMENT OPTIKA GEOMETRY

    Directory of Open Access Journals (Sweden)

    Wawan Bunawan

    2013-06-01

    Full Text Available The objective in this research to explore the relationship between ability of the knowledge essential features inquiry science and their reasons underlying sense of scientific inquiry for physics teacher candidates on content geometrical optics. The essential features of inquiry science are components that should arise during the learning process subject matter of geometrical optics reflectance of light on a flat mirror, the reflection of light on curved mirrors and refraction of light at the lens. Five of essential features inquiry science adopted from assessment system developed by the National Research Council. Content geometrical optics developed from an analysis of a college syllabus material. Based on the study of the essential features of inquiry and content develop the multiple choice diagnostic test three tier. Data were taken from the students who are taking courses in optics and wave from one the LPTK in North Sumatra totaled 38 students. Instruments showed Cronbach alpha reliability of 0.67 to test the essential features of inquiry science and 0.61 to there as on geometrical optics science inquiry.

  14. Assessment of Candidate Molten Salt Coolants for the Advanced High Temperature Reactor (AHTR)

    Energy Technology Data Exchange (ETDEWEB)

    Williams, D.F.

    2006-03-24

    The Advanced High-Temperature Reactor (AHTR) is a novel reactor design that utilizes the graphite-matrix high-temperature fuel of helium-cooled reactors, but provides cooling with a high-temperature fluoride salt. For applications at temperatures greater than 900 C the AHTR is also referred to as a Liquid-Salt-Cooled Very High-Temperature Reactor (LS-VHTR). This report provides an assessment of candidate salts proposed as the primary coolant for the AHTR based upon a review of physical properties, nuclear properties, and chemical factors. The physical properties most relevant for coolant service were reviewed. Key chemical factors that influence material compatibility were also analyzed for the purpose of screening salt candidates. Some simple screening factors related to the nuclear properties of salts were also developed. The moderating ratio and neutron-absorption cross-section were compiled for each salt. The short-lived activation products, long-lived transmutation activity, and reactivity coefficients associated with various salt candidates were estimated using a computational model. Table A presents a summary of the properties of the candidate coolant salts. Certain factors in this table, such as melting point, vapor pressure, and nuclear properties, can be viewed as stand-alone parameters for screening candidates. Heat-transfer properties are considered as a group in Sect. 3 in order to evaluate the combined effects of various factors. In the course of this review, it became apparent that the state of the properties database was strong in some areas and weak in others. A qualitative map of the state of the database and predictive capabilities is given in Table B. It is apparent that the property of thermal conductivity has the greatest uncertainty and is the most difficult to measure. The database, with respect to heat capacity, can be improved with modern instruments and modest effort. In general, ''lighter'' (low-Z) salts tend to

  15. Dialogic and Hortatory Features in the Writing of Chinese Candidates for the IELTS Test

    Science.gov (United States)

    Mayor, Barbara M.

    2006-01-01

    Research conducted in the context of the IELTS Research Program indicates that there are recurrent features in the writing under test conditions of candidates from Chinese language backgrounds, particularly in terms of interpersonal tenor. These include a high level of interpersonal reference, combined with a heavily dialogic and hortatory style.…

  16. 78 FR 43912 - Final Candidate Conservation Agreement with Assurances, Final Environmental Assessment, and...

    Science.gov (United States)

    2013-07-22

    ...-FF02ENEH00] Final Candidate Conservation Agreement with Assurances, Final Environmental Assessment, and Finding of No Significant Impact; Rio Grande Cutthroat Trout, New Mexico and Colorado AGENCY: Fish and... environmental assessment (EA) and the draft Finding of No Significant Impact (FONSI) under the National...

  17. The characterization and testing of candidate immobilization forms for the disposal of plutonium

    International Nuclear Information System (INIS)

    Bakel, A. J.; Buck, E. C.; Chamberlain, D. B.; Ebbinghaus, B. B.; Fortner, J. A.; Marra, J. C.; Mcgrail, B. P.; Mertz, C. J.; Peeler, D. K.; Shaw, H. F.; Strachan, D. M.; Van Konynenburg, R. A.; Vienna, J. D.; Wolf, S. F.

    1997-01-01

    Candidate immobilization forms for the disposal of surplus weapons-useable are being tested and characterized. The goal of the testing program was to provide sufficient data that, by August 1997, an informed selection of a single immobilization form could be made so that the form development and production R and D could be more narrowly focused. Two forms have been under consideration for the past two years: glass and ceramic. In August, 1997, the Department of Energy (DOE) selected ceramic for plutonium disposition, halting further work on the glass material. In this paper, we will briefly describe these two waste forms, then describe our characterization techniques and testing methods. The analytical methods used to characterize altered and unaltered samples are the same. A full suite of microscopic techniques is used. Techniques used include optical, scanning electron, and transmission electron microscopies. For both candidate immobilization forms, the analyses are used to characterize the material for the presence of crystalline phases and amorphous material. Crystalline materials, either in the untested immobilization form or in the alteration products from testing, are characterized with respect to morphology, crystal structure, and composition. The goal of these analyses is to provide data on critical issues such as Pu and neutron absorber volubility in the immobilization form, thermal stability, potential separation of absorber and Pu, and the long-term behavior of the materials. Results from these analyses will be discussed in the presentation. Testing methods include MCC-1 tests, product consistency tests (methods A and B), unsaturated ''drip'' tests, vapor hydration tests, single-pass flow-through tests, and pressurized unsaturated flow tests. Both candidate immobilization forms have very low dissolution rates; examples of typical test results will be reported

  18. Evaluation of Candidate Linear Variable Displacement Transducers for High Temperature Irradiations in the Advanced Test Reactor

    International Nuclear Information System (INIS)

    Knudson, D.L.; Rempe, J.L.; Daw, J.E.

    2009-01-01

    The United States (U.S.) Department of Energy (DOE) designated the Advanced Test Reactor (ATR) as a National Scientific User Facility (NSUF) in April 2007 to promote nuclear science and technology in the U.S. Given this designation, the ATR is supporting new users from universities, laboratories, and industry as they conduct basic and applied nuclear research and development to advance the nation's energy security needs. A fundamental component of the ATR NSUF program is to develop in-pile instrumentation capable of providing real-time measurements of key parameters during irradiation experiments. Dimensional change is a key parameter that must be monitored during irradiation of new materials being considered for fuel, cladding, and structures in next generation and existing nuclear reactors. Such materials can experience significant changes during high temperature irradiation. Currently, dimensional changes are determined by repeatedly irradiating a specimen for a defined period of time in the ATR and then removing it from the reactor for evaluation. The time and labor to remove, examine, and return irradiated samples for each measurement makes this approach very expensive. In addition, such techniques provide limited data (i.e., only characterizing the end state when samples are removed from the reactor) and may disturb the phenomena of interest. To address these issues, the Idaho National Laboratory (INL) recently initiated efforts to evaluate candidate linear variable displacement transducers (LVDTs) for use during high temperature irradiation experiments in typical ATR test locations. Two nuclear grade LVDT vendor designs were identified for consideration - a smaller diameter design qualified for temperatures up to 350 C and a larger design with capabilities to 500 C. Initial evaluation efforts include collecting calibration data as a function of temperature, long duration testing of LVDT response while held at high temperature, and the assessment of changes

  19. DNA Fingerprinting To Improve Data Collection Efficiency and Yield in a Host-Specificity Test of a Weed Biological Control Candidate

    Science.gov (United States)

    An open-field test was conducted in southern France to assess the host-specificity of Ceratapion basicorne, a candidate for biological control of yellow starthistle (Centaurea solstitialis; YST). Test plants were infested by naturally occurring populations of C. basicorne but were also exposed to s...

  20. The Interactive Candidate Assessment Tool: A New Way to Interview Residents.

    Science.gov (United States)

    Platt, Michael P; Akhtar-Khavari, Vafa; Ortega, Rafael; Schneider, Jeffrey I; Fineberg, Tabitha; Grundfast, Kenneth M

    2017-06-01

    The purpose of the residency interview is to determine the extent to which a well-qualified applicant is a good fit with a residency program. However, questions asked during residency interviews tend to be standard and repetitive, and they may not elicit information that best differentiates one applicant from another. The iCAT (interactive Candidate Assessment Tool) is a novel interview instrument that allows both interviewers and interviewees to learn about each other in a meaningful way. The iCAT uses a tablet computer to enable the candidate to select questions from an array of video and nonvideo vignettes. Vignettes include recorded videos regarding some aspect of the program, while other icons include questions within recognizable categories. Postinterview surveys demonstrated advantages over traditional interview methods, with 93% agreeing that it was an innovative and effective tool for conducting residency program interviews. The iCAT for residency interviews is a technological advancement that facilitates in-depth candidate assessment.

  1. Preliminary cleaning tests on candidate materials for APS beamline and front end UHV components

    International Nuclear Information System (INIS)

    Nielsen, R.; Kuzay, T.M.

    1992-01-01

    Comparative cleaning tests have been done on four candidate materials for use in APS beamline and front-end vacuum components. These materials are 304 SS, 304L SS, OFHC copper, and Glidcop* (Cu-Al 2 O 3 )- Samples of each material were prepared and cleaned using two different methods. After cleaning, the sample surfaces were analyzed using ESCA (Electron Spectography for Chemical Analysis). Uncleaned samples were used as a reference. The cleaning methods and surface analysis results are further discussed

  2. Reliability of Scores Obtained from Self-, Peer-, and Teacher-Assessments on Teaching Materials Prepared by Teacher Candidates

    Science.gov (United States)

    Nalbantoglu Yilmaz, Funda

    2017-01-01

    This study aims to determine the reliability of scores obtained from self-, peer-, and teacher-assessments in terms of teaching materials prepared by teacher candidates. The study group of this research constitutes 56 teacher candidates. In the scope of research, teacher candidates were asked to develop teaching material related to their study.…

  3. Assessment of Positive Psychology Course According to Comments and Life Satisfaction Levels of Counselor Candidates

    Science.gov (United States)

    Bas, Asli Uz

    2016-01-01

    The purpose of this study was to assess the "Positive Psychology" course according to comments and life satisfaction levels of counselor candidates. The course was offered in Guidance and Psychological Counseling undergraduate program as an elective course. The participants of the study were 56 senior undergraduate students attended…

  4. Testing the relativistic Doppler boost hypothesis for supermassive black hole binary candidates

    Science.gov (United States)

    Charisi, Maria; Haiman, Zoltán; Schiminovich, David; D'Orazio, Daniel J.

    2018-06-01

    Supermassive black hole binaries (SMBHBs) should be common in galactic nuclei as a result of frequent galaxy mergers. Recently, a large sample of sub-parsec SMBHB candidates was identified as bright periodically variable quasars in optical surveys. If the observed periodicity corresponds to the redshifted binary orbital period, the inferred orbital velocities are relativistic (v/c ≈ 0.1). The optical and ultraviolet (UV) luminosities are expected to arise from gas bound to the individual BHs, and would be modulated by the relativistic Doppler effect. The optical and UV light curves should vary in tandem with relative amplitudes which depend on the respective spectral slopes. We constructed a control sample of 42 quasars with aperiodic variability, to test whether this Doppler colour signature can be distinguished from intrinsic chromatic variability. We found that the Doppler signature can arise by chance in ˜20 per cent (˜37 per cent) of quasars in the nUV (fUV) band. These probabilities reflect the limited quality of the control sample and represent upper limits on how frequently quasars mimic the Doppler brightness+colour variations. We performed separate tests on the periodic quasar candidates, and found that for the majority, the Doppler boost hypothesis requires an unusually steep UV spectrum or an unexpectedly large BH mass and orbital velocity. We conclude that at most approximately one-third of these periodic candidates can harbor Doppler-modulated SMBHBs.

  5. Space Environmental Effects Testing and Characterization of the Candidate Solar Sail Material Aluminized Mylar

    Science.gov (United States)

    Edwards, D. L.; Hubbs, W. S.; Wertz, G. E.; Alstatt, R.; Munafo, Paul (Technical Monitor)

    2001-01-01

    The usage of solar sails as a propellantless propulsion system has been proposed for many years. The technical challenges associated with solar sails are fabrication of ultralightweight films, deploying the sails and controlling the spacecraft. Integral to all these challenges is the mechanical property integrity of the sail while exposed to the harsh environment of space. This paper describes testing and characterization of a candidate solar sail material, Aluminized Mylar. This material was exposed to a simulated Geosynchronous Transfer Orbit (GTO) and evaluated by measuring thermooptical and mechanical property changes. Testing procedures and results are presented.

  6. Eliciting, Identifying, Interpreting, and Responding to Students' Ideas: Teacher Candidates' Growth in Formative Assessment Practices

    Science.gov (United States)

    Gotwals, Amelia Wenk; Birmingham, Daniel

    2016-06-01

    With the goal of helping teacher candidates become well-started beginners, it is important that methods courses in teacher education programs focus on high-leverage practices. Using responsive teaching practices, specifically eliciting, identifying, interpreting, and responding to students' science ideas (i.e., formative assessment), can be used to support all students in learning science successfully. This study follows seven secondary science teacher candidates in a yearlong practice-based methods course. Course assignments (i.e., plans for and reflections on teaching) as well as teaching videos were analyzed using a recursive qualitative approach. In this paper, we present themes and patterns in teacher candidates' abilities to elicit, identify, interpret, and respond to students' ideas. Specifically, we found that those teacher candidates who grew in the ways in which they elicited students' ideas from fall to spring were also those who were able to adopt a more balanced reflection approach (considering both teacher and student moves). However, we found that even the teacher candidates who grew in these practices did not move toward seeing students' ideas as nuanced; rather, they saw students' ideas in a dichotomous fashion: right or wrong. We discuss implications for teacher preparation, specifically for how to promote productive reflection and tools for better understanding students' ideas.

  7. FIVPET Flow-Induced Vibration Test Report (1) - Candidate Spacer Grid Type I (Optimized H Type)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kang Hee; Kang, Heung Seok; Yoon, Kyung Ho; Song, Kee Nam; Kim, Jae Yong

    2006-03-15

    The flow-induced vibration (FIV) test using a 5x5 partial fuel assembly was performed to evaluate mechanical/structural performance of the candidate spacer grid type I (Optimized H shape). From the measured vibration response of the test bundle and the flow parameters, design features of the spacer strap can be analyzed in the point of vibration and hydraulic aspect, and also compared with other spacer strap in simple comparative manner. Furthermore, the FIV test will contributes to understand behaviors of nuclear fuel in operating reactor. The FIV test results will be used to verify the theoretical model of fuel rod and assembly vibration. The aim of this report is to present the results of the FIV test of partial fuel assembly and to introduce the detailed test methodology and analysis procedure. In chapter 2, the overall configuration of test bundle and instrumented tube is remarked and chapter 3 will introduce the test facility (FIVPET) and test section. Chapter 4 deals with overall test condition and procedure, measurement and data acquisition devices, instrumentation equipment and calibration, and error analysis. Finally, test result of vibration and pressure fluctuation is presented and discussed in chapter 5.

  8. Identification and initial assessment of candidate BWR late-phase in-vessel accident management strategies

    International Nuclear Information System (INIS)

    Hodge, S.A.

    1991-01-01

    Work sponsored by the United States Nuclear Regulatory Commission (USNRC) to identify and perform preliminary assessments of candidate BWR [boiling water reactor] in-vessel accident management strategies was completed at Oak Ridge National Laboratory (ORNL) during fiscal year 1990. Mitigative strategies for containment events have been the subject of a companion study at Brookhaven National Laboratory. The focus of this Oak Ridge effort was the development of new strategies for mitigation of the late phase events, that is, the events that would occur in-vessel after the onset of significant core damage. The work began with an investigation of the current status of BWR in-vessel accident management procedures and proceeded through a preliminary evaluation of several candidate new strategies. The steps leading to the identification of the candidate strategies are described. The four new candidate late-phase (in-vessel) accident mitigation strategies identified by this study and discussed in the report are: (1) keep the reactor vessel depressurized; (2) restore injection in a controlled manner; (3) inject boron if control blade damage has occurred; and (4) containment flooding to maintain core and structural debris in-vessel. Additional assessments of these strategies are proposed

  9. Testing candidate interlayers for an enhanced water-cooled divertor target

    International Nuclear Information System (INIS)

    Hancock, David; Barrett, Tom; Foster, James; Fursdon, Mike; Keech, Gregory; McIntosh, Simon; Timmis, William; Rieth, Michael; Reiser, Jens

    2015-01-01

    Highlights: • We introduce an optimised divertor target concept: the “Thermal Break”. • We suggest a candidate interlayer material for this concept: FeltMetal. • We describe a bespoke rig for testing the thermal conductivity of this material. • We present preliminary results for a number of samples. - Abstract: The design of a divertor target for DEMO remains one of the most challenging engineering tasks to be overcome on the path to fusion power. Under the European DEMO programme, a promising concept known as Thermal Break has been developed at CCFE. This concept is a variation of the ITER tungsten divertor in which the pure Copper interlayer between Copper Chrome Zirconium coolant pipe and Tungsten monoblock armour is replaced with a low thermal conductivity compliant interlayer, with the aim of reducing the thermal mismatch stress between the armour and structure. One candidate material for this interlayer is FeltMetal™ (Technetics Group, USA). This material consists of an amorphous matrix of fine copper wires which are sintered onto a thin copper foil, creating a sheet of approximately 1 mm thickness. FeltMetal has been successfully used for many years to provide compliant sliding electrical contacts for the MAST TF coils and on ALCATOR C-Mod and extensive material testing has therefore been undertaken to quantify thermal and mechanical properties. These tests, however, have not been performed under vacuum or DEMO-relevant conditions. A bespoke experimental test rig has therefore been designed and constructed with which to measure the interlayer thermal conductance as a function of temperature and pressure under vacuum conditions. The design of this apparatus and the results of experiments on FeltMetal as well as other candidate interlayers are presented here. In parallel, joint mockups using the candidate interlayers have been prepared and Thermal Break divertor target mockups have been manufactured, requiring the development of a dedicated

  10. Testing candidate interlayers for an enhanced water-cooled divertor target

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, David, E-mail: david.hancock@ccfe.ac.uk [CCFE, Culham Science Centre, Oxfordshire OX14 3DB (United Kingdom); Barrett, Tom; Foster, James; Fursdon, Mike; Keech, Gregory; McIntosh, Simon; Timmis, William [CCFE, Culham Science Centre, Oxfordshire OX14 3DB (United Kingdom); Rieth, Michael; Reiser, Jens [Karlsruhe Institute of Technology, IAM-AWP, P.O. Box 3640, 76021 Karlsruhe (Germany)

    2015-10-15

    Highlights: • We introduce an optimised divertor target concept: the “Thermal Break”. • We suggest a candidate interlayer material for this concept: FeltMetal. • We describe a bespoke rig for testing the thermal conductivity of this material. • We present preliminary results for a number of samples. - Abstract: The design of a divertor target for DEMO remains one of the most challenging engineering tasks to be overcome on the path to fusion power. Under the European DEMO programme, a promising concept known as Thermal Break has been developed at CCFE. This concept is a variation of the ITER tungsten divertor in which the pure Copper interlayer between Copper Chrome Zirconium coolant pipe and Tungsten monoblock armour is replaced with a low thermal conductivity compliant interlayer, with the aim of reducing the thermal mismatch stress between the armour and structure. One candidate material for this interlayer is FeltMetal™ (Technetics Group, USA). This material consists of an amorphous matrix of fine copper wires which are sintered onto a thin copper foil, creating a sheet of approximately 1 mm thickness. FeltMetal has been successfully used for many years to provide compliant sliding electrical contacts for the MAST TF coils and on ALCATOR C-Mod and extensive material testing has therefore been undertaken to quantify thermal and mechanical properties. These tests, however, have not been performed under vacuum or DEMO-relevant conditions. A bespoke experimental test rig has therefore been designed and constructed with which to measure the interlayer thermal conductance as a function of temperature and pressure under vacuum conditions. The design of this apparatus and the results of experiments on FeltMetal as well as other candidate interlayers are presented here. In parallel, joint mockups using the candidate interlayers have been prepared and Thermal Break divertor target mockups have been manufactured, requiring the development of a dedicated

  11. Kepler Data Validation I: Architecture, Diagnostic Tests, and Data Products for Vetting Transiting Planet Candidates

    Science.gov (United States)

    Twicken, Joseph D.; Catanzarite, Joseph H.; Clarke, Bruce D.; Giroud, Forrest; Jenkins, Jon M.; Klaus, Todd C.; Li, Jie; McCauliff, Sean D.; Seader, Shawn E.; Tennenbaum, Peter; hide

    2018-01-01

    The Kepler Mission was designed to identify and characterize transiting planets in the Kepler Field of View and to determine their occurrence rates. Emphasis was placed on identification of Earth-size planets orbiting in the Habitable Zone of their host stars. Science data were acquired for a period of four years. Long-cadence data with 29.4 min sampling were obtained for approx. 200,000 individual stellar targets in at least one observing quarter in the primary Kepler Mission. Light curves for target stars are extracted in the Kepler Science Data Processing Pipeline, and are searched for transiting planet signatures. A Threshold Crossing Event is generated in the transit search for targets where the transit detection threshold is exceeded and transit consistency checks are satisfied. These targets are subjected to further scrutiny in the Data Validation (DV) component of the Pipeline. Transiting planet candidates are characterized in DV, and light curves are searched for additional planets after transit signatures are modeled and removed. A suite of diagnostic tests is performed on all candidates to aid in discrimination between genuine transiting planets and instrumental or astrophysical false positives. Data products are generated per target and planet candidate to document and display transiting planet model fit and diagnostic test results. These products are exported to the Exoplanet Archive at the NASA Exoplanet Science Institute, and are available to the community. We describe the DV architecture and diagnostic tests, and provide a brief overview of the data products. Transiting planet modeling and the search for multiple planets on individual targets are described in a companion paper. The final revision of the Kepler Pipeline code base is available to the general public through GitHub. The Kepler Pipeline has also been modified to support the Transiting Exoplanet Survey Satellite (TESS) Mission which is expected to commence in 2018.

  12. Kepler Data Validation I—Architecture, Diagnostic Tests, and Data Products for Vetting Transiting Planet Candidates

    Science.gov (United States)

    Twicken, Joseph D.; Catanzarite, Joseph H.; Clarke, Bruce D.; Girouard, Forrest; Jenkins, Jon M.; Klaus, Todd C.; Li, Jie; McCauliff, Sean D.; Seader, Shawn E.; Tenenbaum, Peter; Wohler, Bill; Bryson, Stephen T.; Burke, Christopher J.; Caldwell, Douglas A.; Haas, Michael R.; Henze, Christopher E.; Sanderfer, Dwight T.

    2018-06-01

    The Kepler Mission was designed to identify and characterize transiting planets in the Kepler Field of View and to determine their occurrence rates. Emphasis was placed on identification of Earth-size planets orbiting in the Habitable Zone of their host stars. Science data were acquired for a period of four years. Long-cadence data with 29.4 min sampling were obtained for ∼200,000 individual stellar targets in at least one observing quarter in the primary Kepler Mission. Light curves for target stars are extracted in the Kepler Science Data Processing Pipeline, and are searched for transiting planet signatures. A Threshold Crossing Event is generated in the transit search for targets where the transit detection threshold is exceeded and transit consistency checks are satisfied. These targets are subjected to further scrutiny in the Data Validation (DV) component of the Pipeline. Transiting planet candidates are characterized in DV, and light curves are searched for additional planets after transit signatures are modeled and removed. A suite of diagnostic tests is performed on all candidates to aid in discrimination between genuine transiting planets and instrumental or astrophysical false positives. Data products are generated per target and planet candidate to document and display transiting planet model fit and diagnostic test results. These products are exported to the Exoplanet Archive at the NASA Exoplanet Science Institute, and are available to the community. We describe the DV architecture and diagnostic tests, and provide a brief overview of the data products. Transiting planet modeling and the search for multiple planets on individual targets are described in a companion paper. The final revision of the Kepler Pipeline code base is available to the general public through GitHub. The Kepler Pipeline has also been modified to support the Transiting Exoplanet Survey Satellite (TESS) Mission which is expected to commence in 2018.

  13. Collaborative study to assess the suitability of a candidate International Standard for yellow fever vaccine.

    Science.gov (United States)

    Ferguson, Morag; Heath, Alan

    2004-12-01

    Yellow fever vaccines are routinely assayed by plaque assay. However, the results of these assays are then converted into mouse LD(50) using correlations/conversion factors which, in many cases, were established many years ago. The minimum required potency in WHO Recommendations is 10(3) LD(50)/dose. Thirteen participants from 8 countries participated in a collaborative study whose aim was to assess the suitability of two candidate preparations to serve as an International Standard for yellow fever vaccine. In addition, the study investigated the relationship between the mouse LD(50) test and plaque forming units with a view to updating the WHO recommendations. Plaque assays were more reproducible than mouse assays, as expected. Differences in sensitivities of plaque assays were observed between laboratories but these differences appear to be consistent within a laboratory for all samples and the expression of potency relative to the candidate standard vaccine improved the reproducibility of assays between laboratories. However, the use of potencies had little effect on the between laboratory variability in mouse LD(50) assays. There appears to be a consistent relationship between overall mean LD(50) and plaques titre for all study preparations other than sample E. The slope of the correlation curve is >1 and it would appear that 10(3) LD(50) is approximately equivalent to 10(4) plaque forming units (PFU), based on the overall means of all laboratory results. The First International Standard for yellow fever vaccine, NIBSC Code 99/616, has been established as the First International Standard for yellow fever vaccine by the Expert Committee of Biological Standards of the World Health Organisation. The International Standard has been arbitrarily assigned a potency of 10(4.5) International Units (IU) per ampoule. Manufacturers and National Control Laboratories are including the First International Standard for yellow fever vaccine in routine assays so that the minimum

  14. Gastroesophageal reflux symptoms are not sufficient to guide esophageal function testing in lung transplant candidates.

    Science.gov (United States)

    Posner, S; Zheng, J; Wood, R K; Shimpi, R A; Hartwig, M G; Chow, S-C; Leiman, D A

    2018-05-01

    Gastroesophageal reflux disease and esophageal dysmotility are prevalent in patients with advanced lung disease and are associated with graft dysfunction following lung transplantation. As a result, many transplant centers perform esophageal function testing as part of the wait-listing process but guidelines for testing in this population are lacking. The aim of this study is to describe whether symptoms of gastroesophageal reflux correlate with abnormal results on pH-metry and high-resolution manometry and can be used to identify those who require testing. We performed a retrospective cohort study of 226 lung transplant candidates referred for high-resolution manometry and pH-metry over a 12-month period in 2015. Demographic data, results of a standard symptom questionnaire and details of esophageal function testing were obtained. Associations between the presence of symptoms and test results were analyzed using Fisher's exact tests and multivariable logistic regression. The most common lung disease diagnosis was interstitial lung disease (N = 131, 58%). Abnormal pH-metry was seen in 116 (51%) patients and the presence of symptoms was significantly associated with an abnormal study (p advanced lung disease, symptoms of gastroesophageal reflux increase the likelihood of elevated acid exposure on pH-metry but were not associated with dysmotility. Given the proportion of asymptomatic patients with abnormal studies and associated post-transplant risks, a practice of universal high-resolution manometry and pH-metry testing in this population is justifiable.

  15. Methods study of homogeneity and stability test from cerium oxide CRM candidate

    International Nuclear Information System (INIS)

    Samin; Susanna TS

    2016-01-01

    The methods study of homogeneity and stability test from cerium oxide CRM candidate has been studied based on ISO 13258 and KAN DP. 01. 34. The purpose of this study was to select the test method homogeneity and stability tough on making CRM cerium oxide. Prepared 10 sub samples of cerium oxide randomly selected types of analytes which represent two compounds, namely CeO_2 and La_2O_3. At 10 sub sample is analyzed CeO_2 and La_2O_3 contents in duplicate with the same analytical methods, by the same analyst, and in the same laboratory. Data analysis results calculated statistically based on ISO 13528 and KAN DP.01.34. According to ISO 13528 Cerium Oxide samples said to be homogeneous if Ss ≤ 0.3 σ and is stable if | Xr – Yr | ≤ 0.3 σ. In this study, the data of homogeneity test obtained CeO_2 is Ss = 2.073 x 10-4 smaller than 0.3 σ (0.5476) and the stability test obtained | Xr - Yr | = 0.225 and the price is < 0.3 σ. Whereas for La_2O_3, the price for homogeneity test obtained Ss = 1.649 x 10-4 smaller than 0.3 σ (0.4865) and test the stability of the price obtained | Xr - Yr | = 0.2185 where the price is < 0.3 σ. Compared with the method from KAN, a sample of cerium oxide has also been homogenized for Fcalc < Ftable and stable, because | Xi - Xhm | < 0.3 x n IQR. Provided that the results of the evaluation homogeneity and stability test from CeO_2 CRM candidate test data were processed using statistical methods ISO 13528 is not significantly different with statistical methods from KAN DP.01.34, which together meet the requirements of a homogeneous and stable. So the test method homogeneity and stability test based on ISO 13528 can be used to make CRM cerium oxide. (author)

  16. Fireside corrosion testing of candidate superheater tube alloys, coatings, and claddings -- Phase 2 field testing

    Energy Technology Data Exchange (ETDEWEB)

    Blough, J.L. [Foster Wheeler Development Corp., Livingston, NJ (United States)

    1996-08-01

    In Phase 1 of this project, a variety of developmental and commercial tubing alloys and claddings was exposed to laboratory fireside corrosion testing simulating a superheater or reheater in a coal-fired boiler. Phase 2 (in situ testing) has exposed samples of 347, RA85H, HR3C, 253MA, Fe{sub 3}Al + 5Cr, 310 modified, NF 709, 690 clad, and 671 clad for over 10,000 hours to the actual operating conditions of a 250-MW coal-fired boiler. The samples were installed on air-cooled, retractable corrosion probes, installed in the reheater cavity, controlled to the operating metal temperatures of an existing and advanced-cycle, coal-fired boiler. Samples of each alloy are being exposed for 4,000, 12,000, and 16,000 hours of operation. The present results are for the metallurgical examination of the corrosion probe samples after approximately 4,400 hours of exposure.

  17. Irradiation tests of ITER candidate Hall sensors using two types of neutron spectra

    International Nuclear Information System (INIS)

    Duran, I.; Bolshakova, I.; Holyaka, R.; Viererbl, L.; Lahodova, Z.; Sentkerestiova, J.; Bem, P.

    2010-01-01

    We report on irradiation tests of InSb based Hall sensors at two irradiation facilities with two distinct types of neutron spectra. One was a fission reactor neutron spectrum with a significant presence of thermal neutrons, while another one was purely fast neutron field. Total neutron fluence of the order of 10 16 cm -2 was accumulated in both cases, leading to significant drop of Hall sensor sensitivity in case of fission reactor spectrum, while stable performance was observed at purely fast neutron spectrum. This finding suggests that performance of this particular type of Hall sensors is governed dominantly by transmutation. Additionally, it further stresses the need to test ITER candidate Hall sensors under neutron flux with ITER relevant spectrum.

  18. Test reactor risk assessment methodology

    International Nuclear Information System (INIS)

    Jennings, R.H.; Rawlins, J.K.; Stewart, M.E.

    1976-04-01

    A methodology has been developed for the identification of accident initiating events and the fault modeling of systems, including common mode identification, as these methods are applied in overall test reactor risk assessment. The methods are exemplified by a determination of risks to a loss of primary coolant flow in the Engineering Test Reactor

  19. Assessing CPR training: The willingness of teaching credential candidates to provide CPR in a school setting.

    Science.gov (United States)

    Winkelman, Jack L; Fischbach, Ronald; Spinello, Elio F

    2009-12-01

    The study explores the anticipated willingness of teacher credential candidates at one California public university in the U.S. to perform cardiopulmonary resuscitation (CPR) or foreign body airway obstruction (FBAO) skills in a school setting. Objectives included (1) identifying reasons that credential candidates would elect or decline to perform CPR, (2) assisting schools to remediate cardiac/respiratory emergency preparedness, and (3) assessing CPR training courses to determine how they may influence teachers' willingness to perform CPR. Participants included 582 teacher credential candidates, who were 95.2% of those surveyed after completion of a health science course and CPR certification. Participants described their attitudes regarding the importance of CPR, the CPR training course, and their willingness to perform CPR in a school environment. Based upon chi-square analysis, an association was found between the willingness to perform CPR and the presence of any one concern regarding training, with 68.6% of those expressing concerns willing to perform CPR compared to 81.9% of those expressing no concerns (pteachers (76.9% vs. 43.5%, pteachers' willingness to perform CPR. Recommendations based on these findings include pedagogical changes to CPR curricula, focusing on the importance of CPR as a teacher skill and additional time for hands-on practice. Future research should include U.S. and international participants from a broader geographic area and assessment of both learning and affective outcomes.

  20. Comparative testing of six antigen-based malaria vaccine candidates directed toward merozoite-stage Plasmodium falciparum

    DEFF Research Database (Denmark)

    Arnot, David E; Cavanagh, David R; Remarque, Edmond J

    2008-01-01

    Immunogenicity testing of Plasmodium falciparum antigens being considered as malaria vaccine candidates was undertaken in rabbits. The antigens compared were recombinant baculovirus MSP-1(19) and five Pichia pastoris candidates, including two versions of MSP-1(19), AMA-1 (domains I and II), AMA-1......G concentrations. The two P. pastoris-produced MSP-1(19)-induced IgGs conferred the lowest growth inhibition. Comparative analysis of immunogenicity of vaccine antigens can be used to prioritize candidates before moving to expensive GMP production and clinical testing. The assays used have given discriminating...

  1. Fireside corrosion testing of candidate superheater tube alloys, coatings, and claddings -- Phase 2 field testing

    Energy Technology Data Exchange (ETDEWEB)

    Blough, J.L.; Seitz, W.W.; Girshik, A. [Foster Wheeler Development Corp., Livingston, NJ (United States)

    1998-06-01

    In Phase 1 of this project, laboratory experiments were performed on a variety of developmental and commercial tubing alloys and claddings by exposing them to fireside corrosion tests which simulated a superheater or reheater in a coal-fired boiler. Phase 2 (in situ testing) has exposed samples of 347, RA85H, HR3C, RA253MA, Fe{sub 3}Al + 5Cr, Ta-modified 310, NF 709, 690 clad, 671 clad, and 800HT for up to approximately 16,000 hours to the actual operating conditions of a 250-MW, coal-fired boiler. The samples were installed on air-cooled, retractable corrosion probes, installed in the reheater cavity, and controlled to the operating metal temperatures of an existing and advanced-cycle, coal-fired boiler. Samples of each alloy were exposed for 4,483, 11,348, and 15,883 hours of operation. The present results are for the metallurgical examination of the corrosion probe samples after the full 15,883 hours of exposure. A previous topical report has been issued for the 4,483 hours of exposure.

  2. Maladaptive eating behavior assessment among bariatric surgery candidates: Evaluation of the Eating Disorder Diagnostic Scale.

    Science.gov (United States)

    Williams, Gail A; Hawkins, Misty A W; Duncan, Jennifer; Rummell, Christina M; Perkins, Shannon; Crowther, Janis H

    2017-07-01

    Eating pathology among bariatric surgery candidates is common and associated with adverse outcomes. However, its assessment is complicated by the inconsistent use of standardized measures. We addressed this by examining the use of the Eating Disorder Diagnostic Scale (EDDS) in a large bariatric sample (N = 343). To evaluate the EDDS among bariatric surgery candidates via examination of: (1) Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR) and fifth edition (DSM-5) rates of binge eating disorder, bulimia nervosa, and maladaptive eating behaviors, and (2) the relationship between response biases and self-reported eating disorder symptoms. Participants were bariatric surgery candidates at a large public hospital in the Midwest. As part of a larger preoperative evaluation, 343 patients seeking bariatric surgery completed the EDDS and measures of problematic response bias. Approximately 16% of the sample met full threshold criteria for binge eating disorder using DSM-5 criteria. Using the DSM-IV-TR, rates were lower but still substantial at 13%. Rates for bulimia nervosa were 8% (DSM-5) and 6% (DSM-IV-TR). The majority (66.1%) of participants reported at least one binge-eating episode per week. The most commonly used compensatory behavior was fasting (20.4%), followed by excessive exercise (11.7%), laxative use (5.6%), and vomiting (1.8%). An inverse relationship between severity of the eating symptomatology and problematic response bias emerged. The EDDS shows promise as a screening tool that uses diagnostic criteria to provide rates of binge eating and eating psychopathology among surgical candidates. Our findings suggest that subsequent validation studies of this measure are needed, should address potential response bias concerns, and should employ clear definitions of binge eating to promote standardization of eating pathology assessment in the bariatric population. Copyright © 2017 American Society for Bariatric

  3. Testing popular VaR models in EU new member and candidate states

    Directory of Open Access Journals (Sweden)

    Saša Žiković

    2007-12-01

    Full Text Available The impact of allowing banks to calculate their capital requirement based on their internal VaR models, and the impact of regulation changes on banks in transitional countries has not been well studied. This paper examines whether VaR models that are created and suited for developed markets apply to the volatile stock markets of EU new member and candidate states (Bulgaria, Romania, Croatia and Turkey. Nine popular VaR models are tested on five stock indexes from EU new member and candidate states. Backtesting results show that VaR models commonly used in developed stock markets are not well suited for measuring market risk in these markets. Presented findings bear very important implications that have to be addressed by regulators and risk practitioners operating in EU new member andcandidate states. Risk managers have to start thinking outside the frames set by their parent companies or else investors present in these markets may find themselves in serious trouble, dealing with losses that they have not been expecting. National regulators have to take into consideration that simplistic VaR models that are widely used in some developed countries are not well suited for these illiquid and developing stock markets.

  4. Development and testing of new candidate psoriatic arthritis screening questionnaires combining optimal questions from existing tools.

    Science.gov (United States)

    Coates, Laura C; Walsh, Jessica; Haroon, Muhammad; FitzGerald, Oliver; Aslam, Tariq; Al Balushi, Farida; Burden, A D; Burden-Teh, Esther; Caperon, Anna R; Cerio, Rino; Chattopadhyay, Chandrabhusan; Chinoy, Hector; Goodfield, Mark J D; Kay, Lesley; Kelly, Stephen; Kirkham, Bruce W; Lovell, Christopher R; Marzo-Ortega, Helena; McHugh, Neil; Murphy, Ruth; Reynolds, Nick J; Smith, Catherine H; Stewart, Elizabeth J C; Warren, Richard B; Waxman, Robin; Wilson, Hilary E; Helliwell, Philip S

    2014-09-01

    Several questionnaires have been developed to screen for psoriatic arthritis (PsA), but head-to-head studies have found limitations. This study aimed to develop new questionnaires encompassing the most discriminative questions from existing instruments. Data from the CONTEST study, a head-to-head comparison of 3 existing questionnaires, were used to identify items with a Youden index score of ≥0.1. These were combined using 4 approaches: CONTEST (simple additions of questions), CONTESTw (weighting using logistic regression), CONTESTjt (addition of a joint manikin), and CONTESTtree (additional questions identified by classification and regression tree [CART] analysis). These candidate questionnaires were tested in independent data sets. Twelve individual questions with a Youden index score of ≥0.1 were identified, but 4 of these were excluded due to duplication and redundancy. Weighting for 2 of these questions was included in CONTESTw. Receiver operating characteristic (ROC) curve analysis showed that involvement in 6 joint areas on the manikin was predictive of PsA for inclusion in CONTESTjt. CART analysis identified a further 5 questions for inclusion in CONTESTtree. CONTESTtree was not significant on ROC curve analysis and discarded. The other 3 questionnaires were significant in all data sets, although CONTESTw was slightly inferior to the others in the validation data sets. Potential cut points for referral were also discussed. Of 4 candidate questionnaires combining existing discriminatory items to identify PsA in people with psoriasis, 3 were found to be significant on ROC curve analysis. Testing in independent data sets identified 2 questionnaires (CONTEST and CONTESTjt) that should be pursued for further prospective testing. Copyright © 2014 by the American College of Rheumatology.

  5. Assessment on separate effect tests

    International Nuclear Information System (INIS)

    Bernard, M.; Kukita, Y.; Renault, C.

    1985-01-01

    In the general frame of Cathare assessment this operation is aimed to qualify the set of constitutive laws by reconstitution of experimental tests. The experimental tests are selected following 2 objectives: to be able to qualify separately (as far as possible) the constitutive laws, and, to cover the entire parameter range which is of interest for safety studies. This selection has led to a set of 135 separate effect tests taken from 15 experimental facilities and which can be arranged in 3 main categories: Adiabatic flow tests, without significant external heat exchange; non adiabatic flow tests, in which external heating or cooling is applied to the test section but not being driven by wall heat exchange; and, heat transfer tests, in which wall heat transfer plays the dominant role

  6. Status of the assessment phase of the ESA M3 mission candidate LOFT

    Science.gov (United States)

    Corral van Damme, Carlos; Ayre, Mark; Lumb, David; Short, Alexander D.; Rando, Nicola

    2012-09-01

    LOFT (Large Observatory For x-ray Timing) is one of four candidates for the M3 slot (launch in 2024, with the option of a launch in 2022) of ESAs Cosmic Vision 2015 - 2025 Plan, and as such it is currently undergoing an initial assessment phase lasting one year. The objective of the assessment phase is to provide the information required to enable the down selection process, in particular: the space segment definition for meeting the assigned science objectives; consideration of and initial definition of the implementation schedule; an estimate of the mission Cost at Completion (CaC); an evaluation of the technology readiness evaluation and risk assessment. The assessment phase is divided into two interleaved components: (i) A payload assessment study, performed by teams funded by member states, which is primarily intended for design, definition and programmatic/cost evaluation of the payload, and (ii) A system industrial study, which has essentially the same objectives for the space segment of the mission. This paper provides an overview of the status of the LOFT assessment phase, both for payload and platform. The initial focus is on the payload design status, providing the reader with an understanding of the main features of the design. Then the space segment assessment study status is presented, with an overview of the principal challenges presented by the LOFT payload and mission requirements, and a presentation of the expected solutions. Overall the mission is expected to enable cutting-edge science, is technically feasible, and should remain within the required CaC for an M3 candidate.

  7. Simplified Abrasion Test Methodology for Candidate EVA Glove Lay-Ups

    Science.gov (United States)

    Rabel, Emily; Aitchison, Lindsay

    2015-01-01

    During the Apollo Program, space suit outer-layer fabrics were badly abraded after performing just a few extravehicular activities (EVAs). For example, the Apollo 12 commander reported abrasive wear on the boots that penetrated the outer-layer fabric into the thermal protection layers after less than 8 hrs of surface operations. Current plans for the exploration planetary space suits require the space suits to support hundreds of hours of EVA on a lunar or Martian surface, creating a challenge for space suit designers to utilize materials advances made over the last 40 years and improve on the space suit fabrics used in the Apollo Program. Over the past 25 years the NASA Johnson Space Center Crew and Thermal Systems Division has focused on tumble testing as means of simulating wear on the outer layer of the space suit fabric. Most recently, in 2009, testing was performed on 4 different candidate outer layers to gather baseline data for future use in design of planetary space suit outer layers. In support of the High Performance EVA Glove Element of the Next Generation Life Support Project, testing a new configuration was recently attempted in which require 10% of the fabric per replicate of that need in 2009. The smaller fabric samples allowed for reduced per sample cost and flexibility to test small samples from manufacturers without the overhead to have a production run completed. Data collected from this iteration was compared to that taken in 2009 to validate the new test method. In addition the method also evaluated the fabrics and fabric layups used in a prototype thermal micrometeoroid garment (TMG) developed for EVA gloves under the NASA High Performance EVA Glove Project. This paper provides a review of previous abrasion studies on space suit fabrics, details methodologies used for abrasion testing in this particular study, results of the validation study, and results of the TMG testing.

  8. Mechanical characterization tests of a candidate skeleton for X-Gen fuel assembly

    International Nuclear Information System (INIS)

    Kim, Hyung Kyu; Yoon, Kyung Ho; Lee, Kang Hee; Kim, Jae Yong; Lee, Young Ho

    2007-09-01

    Since the KNFC (KEPCO Nuclear Fuel Co.) requested a mechanical characterization tests of a candidate skeleton for X-Gen fuel assembly (some welding locations of a center guide tube are free of welding compared with the PLUS7 case) were requested, transverse vibration and stiffness tests were carried out by using the FAMeCT. The major results are as follows. - Transverse vibration test There was no distinguishable discrepancy in the free vibration characteristics between the skeleton without welding at some locations of a center guide tube and that of original assembly (PLUS7; welded at every spacer grid locations). The natural frequencies were measured as 6.8 - 6.9 for the 1st mode; 17.7 - 18.3 for the 2nd mode; 30.2 - 31.2 for the 3rd mode; 50.4 - 52.1 Hz for the 4th mode. As a result, the difference in the vibration characteristics was extremely small regardless of the number of welding of a center guide tube. - Transverse bending test. The transverse bending test results of the X-Gen no. 2 were similar to those of the PLUS7 skeleton. The relationship between the force and displacement was found linear. 521 N was observed at the deflection of 30 mm, and the stiffness at the 6th grid location (load exerting location) was 17.4, 16.3 N/mm in the two consecutive tests. The displacements at the grid locations lower than the 6th grid were at bit smaller than those upper than that due to a comparatively higher rigidity

  9. Testing of candidate non-lethal sampling methods for detection of Renibacterium salmoninarum in juvenile Chinook salmon Oncorhynchus tshawytscha

    Science.gov (United States)

    Elliott, Diane G.; McKibben, Constance L.; Conway, Carla M.; Purcell, Maureen K.; Chase, Dorothy M.; Applegate, Lynn M.

    2015-01-01

    Non-lethal pathogen testing can be a useful tool for fish disease research and management. Our research objectives were to determine if (1) fin clips, gill snips, surface mucus scrapings, blood draws, or kidney biopsies could be obtained non-lethally from 3 to 15 g Chinook salmon Oncorhynchus tshawytscha, (2) non-lethal samples could accurately discriminate between fish exposed to the bacterial kidney disease agent Renibacterium salmoninarum and non-exposed fish, and (3) non-lethal samples could serve as proxies for lethal kidney samples to assess infection intensity. Blood draws and kidney biopsies caused ≥5% post-sampling mortality (Objective 1) and may be appropriate only for larger fish, but the other sample types were non-lethal. Sampling was performed over 21 wk following R. salmoninarum immersion challenge of fish from 2 stocks (Objectives 2 and 3), and nested PCR (nPCR) and real-time quantitative PCR (qPCR) results from candidate non-lethal samples were compared with kidney tissue analysis by nPCR, qPCR, bacteriological culture, enzyme-linked immunosorbent assay (ELISA), fluorescent antibody test (FAT) and histopathology/immunohistochemistry. R. salmoninarum was detected by PCR in >50% of fin, gill, and mucus samples from challenged fish. Mucus qPCR was the only non-lethal assay exhibiting both diagnostic sensitivity and specificity estimates >90% for distinguishing between R. salmoninarum-exposed and non-exposed fish and was the best candidate for use as an alternative to lethal kidney sample testing. Mucus qPCR R. salmoninarum quantity estimates reflected changes in kidney bacterial load estimates, as evidenced by significant positive correlations with kidney R. salmoninaruminfection intensity scores at all sample times and in both fish stocks, and were not significantly impacted by environmentalR. salmoninarum concentrations.

  10. Corrosion Assessment of Candidate Materials for the SHINE Subcritical Assembly Vessel and Components FY14 Report

    Energy Technology Data Exchange (ETDEWEB)

    Pawel, Steven J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-10-01

    Laboratory corrosion testing of candidate alloys—including Zr-4 and Zr-2.5Nb representing the target solution vessel, and 316L, 2304, 304L, and 17-4 PH stainless steels representing process piping and balance-of-plant components—was performed in support of the proposed SHINE process to produce 99Mo from low-enriched uranium. The test solutions used depleted uranyl sulfate in various concentrations and incorporated a range of temperatures, excess sulfuric acid concentrations, nitric acid additions (to simulate radiolysis product generation), and iodine additions. Testing involved static immersion of coupons in solution and in the vapor above the solution, and was extended to include planned-interval tests to examine details associated with stainless steel corrosion in environments containing iodine species. A large number of galvanic tests featuring couples between a stainless steel and a zirconium-based alloy were performed, and limited vibratory horn testing was incorporated to explore potential erosion/corrosion features of compatibility. In all cases, corrosion of the zirconium alloys was observed to be minimal, with corrosion rates based on weight loss calculated to be less than 0.1 mil/year with no change in surface roughness. The resulting passive film appeared to be ZrO2 with variations in thickness that influence apparent coloration (toward light brown for thicker films). Galvanic coupling with various stainless steels in selected exposures had no discernable effect on appearance, surface roughness, or corrosion rate. Erosion/corrosion behavior was the same for zirconium alloys in uranyl sulfate solutions and in sodium sulfate solutions adjusted to a similar pH, suggesting there was no negative effect of uranium resulting from fluid dynamic conditions aggressive to the passive film. Corrosion of the candidate stainless steels was similarly modest across the entire range of exposures. However, some sensitivity to corrosion of the stainless steels was

  11. Characterization of a backfill candidate material, IBECO-RWC-BF Baclo Project - Phase 3 Laboratory tests

    International Nuclear Information System (INIS)

    Johannesson, Lars-Erik; Sanden, Torbjoern; Dueck, Ann; Ohlsson, Lars

    2010-01-01

    A backfill candidate material, IBECO-RWC-BF, which origin from Milos, Greece, has been investigated. The material was delivered both as granules and as pellets. The investigation described in this report aimed to characterize the material and evaluate if it can be used in a future repository. The following investigations have been done and are presented in this report: 1. Standard laboratory tests. Water content, liquid limit and swelling potential are examples on standard tests that have been performed. 2. Block manufacturing. The block compaction properties of the material have been determined. A first test was performed in laboratory but also tests in large scale have been performed. After finishing the test phase, 60 tons of blocks were manufactured at Hoeganaes Bjuf AB. The blocks will be used in large scale laboratory tests at Aespoe HRL. 3. Mechanical parameters. The compressibility of the material was investigated with oedometer tests (four tests) where the load was applied in steps after saturation. The evaluated oedometer modulus varied between 34.50 MPa. Tests were made to evaluate the elastic parameters of the material (E, ν). Altogether three tests were made on specimens with dry densities of about 1,710 kg/m 3 . The evaluated E-modulus and Poisson's ratio varied between 231-263 MPa and 0.16-0.19 respectively. The strength of the material, both the compressive strength and the tensile strength were measured on specimens compacted to different dry densities. The test results yielded a relation between density and the two types of strength. Furthermore, tests have been made in order to determine the compressibility of the unsaturated filling of pellets. Two tests were made where the pellets were loosely filled in a Proctor cylinder and then compressed at a constant rate of strain during continuously measurement of the applied load. 4. Swelling pressure and hydraulic conductivity. There is, as expected, a very clear influence of the dry density on the

  12. Scoping corrosion tests on candidate waste package basket materials for the Yucca Mountain project

    International Nuclear Information System (INIS)

    Konynenburg, R.A. van; Curtis, P.G.; Summers, T.S.E.

    1998-03-01

    A scoping corrosion test was performed on candidate waste package basket materials. The corrosion medium was a pH-buffered solution of chemical species expected to be produced by radiolysis. The test was conducted at 90 C for 96 hours. Samples included aluminum-, copper-, stainless steel- and zirconium-based metallic materials and several ceramics, incorporating neutron-absorbing elements. Sample weight losses and solution chemical changes were measured. Both corrosion of the host materials and dissolution of the neutron-absorbing elements were studied. The ceramics and the zirconium-based materials underwent only minor corrosion. The stainless steel-based materials performed well except for a welded sample. The aluminum- and copper-based materials exhibited the highest corrosion rates. Boron dissolution depends on its chemical form. Boron oxide and many metal borides dissolve readily in acidic solutions while high-chromium borides and boron carbide, though thermodynamically unstable, exhibit little dissolution in short times. The results of solution chemical analyses were consistent with this. Gadolinium did not dissolve significantly from monazite, and hafnium showed little dissolution from a variety of host materials, in keeping with its low solubility

  13. Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior

    DEFF Research Database (Denmark)

    Rohde, Palle Duun; Madsen, Lisbeth Strøm; Arvidson, Sandra Marie Neumann

    2016-01-01

    Fruit flies are important model organisms for functional testing of candidate genes in multiple disciplines, including the study of human diseases. Here we use a high-throughput locomotor activity assay to test the response on activity behavior of gene disruption in Drosophila melanogaster. The aim...

  14. Characterization of a backfill candidate material, IBECO-RWC-BF Baclo Project - Phase 3 Laboratory tests

    Energy Technology Data Exchange (ETDEWEB)

    Johannesson, Lars-Erik; Sanden, Torbjoern; Dueck, Ann; Ohlsson, Lars (Clay Technology AB, Lund (Sweden))

    2010-01-15

    A backfill candidate material, IBECO-RWC-BF, which origin from Milos, Greece, has been investigated. The material was delivered both as granules and as pellets. The investigation described in this report aimed to characterize the material and evaluate if it can be used in a future repository. The following investigations have been done and are presented in this report: 1. Standard laboratory tests. Water content, liquid limit and swelling potential are examples on standard tests that have been performed. 2. Block manufacturing. The block compaction properties of the material have been determined. A first test was performed in laboratory but also tests in large scale have been performed. After finishing the test phase, 60 tons of blocks were manufactured at Hoeganaes Bjuf AB. The blocks will be used in large scale laboratory tests at Aespoe HRL. 3. Mechanical parameters. The compressibility of the material was investigated with oedometer tests (four tests) where the load was applied in steps after saturation. The evaluated oedometer modulus varied between 34.50 MPa. Tests were made to evaluate the elastic parameters of the material (E, nu). Altogether three tests were made on specimens with dry densities of about 1,710 kg/m3. The evaluated E-modulus and Poisson's ratio varied between 231-263 MPa and 0.16-0.19 respectively. The strength of the material, both the compressive strength and the tensile strength were measured on specimens compacted to different dry densities. The test results yielded a relation between density and the two types of strength. Furthermore, tests have been made in order to determine the compressibility of the unsaturated filling of pellets. Two tests were made where the pellets were loosely filled in a Proctor cylinder and then compressed at a constant rate of strain during continuously measurement of the applied load. 4. Swelling pressure and hydraulic conductivity. There is, as expected, a very clear influence of the dry density on the

  15. Integrated Corrosion Facility for long-term testing of candidate materials for high-level radioactive waste containment

    International Nuclear Information System (INIS)

    Estill, J.C.; Dalder, E.N.C.; Gdowski, G.E.; McCright, R.D.

    1994-10-01

    A long-term-testing facility, the Integrated Corrosion Facility (I.C.F.), is being developed to investigate the corrosion behavior of candidate construction materials for high-level-radioactive waste packages for the potential repository at Yucca Mountain, Nevada. Corrosion phenomena will be characterized in environments considered possible under various scenarios of water contact with the waste packages. The testing of the materials will be conducted both in the liquid and high humidity vapor phases at 60 and 90 degrees C. Three classes of materials with different degrees of corrosion resistance will be investigated in order to encompass the various design configurations of waste packages. The facility is expected to be in operation for a minimum of five years, and operation could be extended to longer times if warranted. A sufficient number of specimens will be emplaced in the test environments so that some can be removed and characterized periodically. The corrosion phenomena to be characterized are general, localized, galvanic, and stress corrosion cracking. The long-term data obtained from this study will be used in corrosion mechanism modeling, performance assessment, and waste package design. Three classes of materials are under consideration. The corrosion resistant materials are high-nickel alloys and titanium alloys; the corrosion allowance materials are low-alloy and carbon steels; and the intermediate corrosion resistant materials are copper-nickel alloys

  16. Stress Tests and Vulnerability Assessment

    International Nuclear Information System (INIS)

    Wallner, A.; Lorenz, P.

    2012-01-01

    After the accident in Fukushima, nuclear safety as topic in anti-nuclear work has gained importance within the Joint Project countries. Therefore, nuclear safety and in particular the activities of the European stress tests were chosen to be the main focus of the Joint Project 2011/2012 as well as the common theme of the national projects. This brochure describes: A) Vulnerability Assessment A critical review of the EU Nuclear Stress Tests in Bulgaria, Hungary, Romania and Ukraine is presented in chapter 1. The review details the main weaknesses identified within the stress tests. Important shortcomings not mentioned in the stress tests reports are also discussed. These evaluations do not claim to be exhaustive, but the findings contribute to a more comprehensive understanding of safety and risk of nuclear power plants in Europe. B) Transparency of the stress tests In chapter 2 the experience of the Joint Project NGOs concerning transparency of the stress tests is presented. The information is not meant to be an evaluation of the transparency of the stress tests in general – such an evaluation is not possible within the scope of this brochure. The evaluation aims to show activities concerning stress tests and how they were conceived by the JP NGOs. Some recommendations for improvement are given. C) Safety focus Within the main topic “nuclear safety” of the Joint Project 2011/2012 the NGOs of each JP country selected a special safety relevant topic, which is/was of particular interest in their country: Bulgaria: The short story of Belene NPP – The victory – Key points of the campaign against the nuclear power plant Romania: Risks of the CANDU reactor design Czech Republic: Results of the conference “Power Plant Load Testing: Safety Inspection or Propaganda?“ Slovakia: Safety deficits of the NPP Mochovce These safety relevant issues are discussed in separate sections within the brochure at hand. (author)

  17. Stress Tests and Vulnerability Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Wallner, A. [Austrian Institute of Ecology, Vienna (Austria); Lorenz, P. [ed.; Becker, O. [eds.; Weber, U. [Austrian Institute of Ecology, Vienna (Austria)

    2012-07-01

    After the accident in Fukushima, nuclear safety as topic in anti-nuclear work has gained importance within the Joint Project countries. Therefore, nuclear safety and in particular the activities of the European stress tests were chosen to be the main focus of the Joint Project 2011/2012 as well as the common theme of the national projects. This brochure describes: A) Vulnerability Assessment A critical review of the EU Nuclear Stress Tests in Bulgaria, Hungary, Romania and Ukraine is presented in chapter 1. The review details the main weaknesses identified within the stress tests. Important shortcomings not mentioned in the stress tests reports are also discussed. These evaluations do not claim to be exhaustive, but the findings contribute to a more comprehensive understanding of safety and risk of nuclear power plants in Europe. B) Transparency of the stress tests In chapter 2 the experience of the Joint Project NGOs concerning transparency of the stress tests is presented. The information is not meant to be an evaluation of the transparency of the stress tests in general – such an evaluation is not possible within the scope of this brochure. The evaluation aims to show activities concerning stress tests and how they were conceived by the JP NGOs. Some recommendations for improvement are given. C) Safety focus Within the main topic “nuclear safety” of the Joint Project 2011/2012 the NGOs of each JP country selected a special safety relevant topic, which is/was of particular interest in their country: Bulgaria: The short story of Belene NPP – The victory – Key points of the campaign against the nuclear power plant Romania: Risks of the CANDU reactor design Czech Republic: Results of the conference “Power Plant Load Testing: Safety Inspection or Propaganda?“ Slovakia: Safety deficits of the NPP Mochovce These safety relevant issues are discussed in separate sections within the brochure at hand. (author)

  18. Pick and Eat Crop Testing: Dwarf Tomato and Pepper as Candidate Space Crops

    Science.gov (United States)

    Wheeler, R. M.; Massa, G. D.; Stutte, G. W.; Spencer, L. E.; Hummerick, M. E.; Sirmons, T.; Douglas, G. L.

    2016-01-01

    Several dwarf tomato and pepper varieties were evaluated under International Space Station (ISS)-simulated growth conditions (22 degrees Centigrade, 50 percent relative humidity, 1500 parts per million CO2, and 300 micromoles per square meter per second of light for 16 hours per day) with the goal of selecting those with the best growth, nutrition, and organoleptic potential for use in a pick and eat salad crop system on ISS and future exploration flights. Testing included six cultivars of tomato (Red Robin, Scarlet Sweet 'N' Neat, Tiny Tim, Mohamed, Patio Princess, and Tumbler) and six cultivars of pepper (Red Skin, Fruit Basket, Cajun Belle, Chablis, Sweet Pickle, and Pompeii). Plants were grown to an age sufficient to produce fruit (up to 106 days for tomato and 109 days for pepper) using Turface (arcillite) potting media with 18-6-8 control-release fertilizer and supplemental nutrient solution beginning around 60-days-age. Tomato fruits were harvested when they showed full red color, beginning around 70-days age and then at weekly intervals thereafter, while peppers were grown until fruits showed color and were harvested twice (first test) and just once at the end of the second test, with the final harvests including colored and green fruit. Plant sizes, yields, and nutritional attributes were measured and used to down-select to three cultivars for each species. In particular, we were interested in cultivars that were short (dwarf) but still produced high yields. Nutritional data included elemental (Ca, Mg, Fe, and K) content, vitamin K, phenolics, lycopene (for tomato), anthocyanin, lutein, and zeaxanthin. The three down-selected cultivars for each species were grown again and the harvested fruit sent to NASA's Johnson Space Center for sensory evaluation, which included overall acceptability, appearance, color intensity, aroma, flavor and texture. The combined data were compared and given weighting factors to rank the cultivars as candidates for testing in

  19. Short-term stability test for thorium soil candidate a reference material

    Energy Technology Data Exchange (ETDEWEB)

    Clain, Almir F.; Fonseca, Adelaide M.G.; Dantas, Vanessa V.D.B.; Braganca, Maura J.C.; Souza, Poliana S., E-mail: almir@ird.gov.br, E-mail: adelaide@ird.gov.br, E-mail: vanessa@ird.gov.br, E-mail: maura@ird.gov.br, E-mail: poliana@bolsista.ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    This work describes a methodology to determine the soil short-term stability after the steps of production in laboratory. The short-term stability of the soil is an essential property to be determined in order to producing a reference material. The soil is a candidate of reference material for chemical analysis of thorium with metrological traceability to be used in environmental analysis, equipment calibration, validation methods, and quality control. A material is considered stable in a certain temperature if the property of interest does not change with time, considering the analytical random fluctuations. Due to this, the angular coefficient from the graphic of Th concentration versus elapsed time must be near to zero. The analytical determinations of thorium concentration were performed by Instrumental Neutron activation Analysis. The slopes and their uncertainties were obtained from the regression lines at temperatures of 20 deg C and 60 deg C, with control temperature of -20 deg C. From the obtained data a t-test was applied. In both temperatures the calculated t-value was lower than the critical value, so we can conclude with 95% confidence level that no significant changes happened during the period studied concerning thorium concentration in soil at temperatures of 20 deg C and 60 deg C, showing stability at these temperatures. (author)

  20. Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning.

    Science.gov (United States)

    Herbert, Julia; Thiermann, Horst; Worek, Franz; Wille, Timo

    2017-08-15

    Standard therapeutic options in organophosphate (OP) poisoning are limited to the administration of atropine and oximes, a regimen often lacking in efficacy and applicability. Treatment alternatives are needed, preferably covering a broad spectrum of OP intoxications. Although recent research yielded several promising compounds, e.g. bioscavengers, modulators of the muscarinic acetylcholine (ACh) receptor or bispyridinium non-oximes, these substances still need further evaluation, especially regarding effects on the potentially lethal respiratory symptoms of OP poisoning. Aim of this study was the development of an applicable and easy method to test the therapeutic efficiency of such substances. For this purpose, airway responsiveness in viable precision cut lung slices (PCLS) from rats was analysed. We showed that ACh-induced airway contractions were spontaneously reversible in non-poisoned PCLS, whereas in OP poisoned PCLS, contractions were irreversible. This effect could be antagonized by addition of the standard therapeutic atropine, thereby presenting a clear indication for treatment efficiency. Now, candidate therapeutic compounds can be evaluated, based on their ability to counteract the irreversible airway contraction in OP poisoned PCLS. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Short-term stability test for thorium soil candidate a reference material

    International Nuclear Information System (INIS)

    Clain, Almir F.; Fonseca, Adelaide M.G.; Dantas, Vanessa V.D.B.; Braganca, Maura J.C.; Souza, Poliana S.

    2015-01-01

    This work describes a methodology to determine the soil short-term stability after the steps of production in laboratory. The short-term stability of the soil is an essential property to be determined in order to producing a reference material. The soil is a candidate of reference material for chemical analysis of thorium with metrological traceability to be used in environmental analysis, equipment calibration, validation methods, and quality control. A material is considered stable in a certain temperature if the property of interest does not change with time, considering the analytical random fluctuations. Due to this, the angular coefficient from the graphic of Th concentration versus elapsed time must be near to zero. The analytical determinations of thorium concentration were performed by Instrumental Neutron activation Analysis. The slopes and their uncertainties were obtained from the regression lines at temperatures of 20 deg C and 60 deg C, with control temperature of -20 deg C. From the obtained data a t-test was applied. In both temperatures the calculated t-value was lower than the critical value, so we can conclude with 95% confidence level that no significant changes happened during the period studied concerning thorium concentration in soil at temperatures of 20 deg C and 60 deg C, showing stability at these temperatures. (author)

  2. Focal species candidates for pesticide risk assessment in European rice fields: A review.

    Science.gov (United States)

    Vallon, Martin; Dietzen, Christian; Laucht, Silke; Ludwigs, Jan-Dieter

    2018-04-25

    An assessment of potential risks of pesticides on wildlife is required during the process of product registration within Europe because of the importance of agricultural landscapes as wildlife habitats. Despite their peculiarity and their specific role as artificial wetlands, rice paddies are to date pooled with cereals in guidance documents on how to conduct risk assessments for birds and mammals in Europe. Hence, the focal species currently considered in risk assessments for rice paddies are those known from cereal fields and can therefore be expected to differ significantly from the species actually occurring in the wet environments of rice paddies. We present results of a comprehensive review on bird and mammal species regularly occurring in rice paddies during a time of potential pesticide exposure to identify appropriate focal species candidates for ecotoxicological pesticide risk assessment according to the European Food Safety Authority (EFSA). In addition, we present data on rice cultivation areas and agricultural practices in Europe to give background information supporting the species selection process. Our literature search identified a general scarcity of relevant data, particularly for mammals, which highlights the need for crop-specific focal species studies. However, our results clearly indicate that the relevant bird and mammal species in rice fields indeed differ strongly from the focal species used for the cereal risk assessment. They can thus be used as a baseline for more realistic wildlife risk assessments specific to rice and the development of a revised guidance document to bridge the gap for regulatory decision makers. Integr Environ Assess Manag 2018;00:000-000. © 2018 SETAC. © 2018 SETAC.

  3. Assessing the candidate in the selection interview: The role of interviewer’s personality

    Directory of Open Access Journals (Sweden)

    Čerović Sofija

    2018-01-01

    Full Text Available The study explores the relative contribution of interviewers’ personality and interviewers’ ratings of candidate’s personality in predicting interviewers’ ratings of candidate’s job suitability and examines the moderating effect of interviewers’ personality on the relationship between ratings of candidate’s personality and job suitability. Results showed that ratings of candidate’s Big Five personality traits were related to ratings of candidate’s job suitability, as well as were interviewers’ Agreeableness and Extraversion. Interviewers’ Openness and Agreeableness had a moderating effect on the relationship between interviewers’ ratings of candidate’s personality traits and ratings of candidate’s job suitability. Results reveal the role that interviewer’s Agreeableness, Extraversion and Openness play in the assessment of candidate in the selection interview.

  4. Predicting Performance: A Comparison of University Supervisors' Predictions and Teacher Candidates' Scores on a Teaching Performance Assessment

    Science.gov (United States)

    Sandholtz, Judith Haymore; Shea, Lauren M.

    2012-01-01

    The implementation of teaching performance assessments has prompted a range of concerns. Some educators question whether these assessments provide information beyond what university supervisors gain through their formative evaluations and classroom observations of candidates. This research examines the relationship between supervisors' predictions…

  5. The Flawed Characters in the Campaign: Prestige Newspaper Assessments of the 1992 Presidential Candidates' Integrity and Competence.

    Science.gov (United States)

    King, Erika G.

    1995-01-01

    Examines coverage in three leading newspapers, finding that explicit assessments of the 1992 presidential candidates' character were present in seven percent of all news articles and one-third of op-ed items, with the vast majority unfavorable. Shows that Bill Clinton was consistently assessed as a "slippery obfuscator," George Bush as…

  6. Assessing anti-T. cruzi candidates in vitro for sterile cidality

    Directory of Open Access Journals (Sweden)

    Monica Cal

    2016-12-01

    Full Text Available Total clearance of the T. cruzi infection – referred to herein as “sterile cure” – seems to be a critical prerequisite for new drug candidates for Chagas disease, ensuring long-term beneficial effects for patients in the chronic indeterminate stage. This requirement is notably supported by the recent findings of clinical studies involving posaconazole and fosravuconazole, where the majority of patients treated eventually relapsed after an apparent clearance of parasitaemia at the end of treatment. We have adapted an in vitro system to predict the ability of a compound to deliver sterile cure. It relies on mouse peritoneal macrophages as host cells for Trypanosoma cruzi amastigotes. The macrophages do not proliferate, allowing for long-term testing and wash-out experiments. Giemsa staining followed by microscopy provides a highly sensitive and specific tool to quantify the numbers of infected host cells. Combining macrophages as host cells and Giemsa staining as the read-out, we demonstrate that posaconazole and other CYP51 inhibitors are unable to achieve complete clearance of an established T. cruzi infection in vitro in spite of the fact that these compounds are active at significantly lower concentrations than the reference drugs benznidazole and nifurtimox. Indeed, a few macrophages remained infected after 96 h of drug incubation in the presence of CYP51 inhibitors–albeit at a very low parasite load. These residual T. cruzi amastigotes were shown to be viable and infective, as demonstrated by wash-out experiments. We advocate characterizing any new anti-T. cruzi early stage candidates for sterile cidality early in the discovery cascade, as a surrogate for delivery of sterile cure in vivo.

  7. High Temperature Steam Oxidation Testing of Candidate Accident Tolerant Fuel Cladding Materials

    Energy Technology Data Exchange (ETDEWEB)

    Pint, Bruce A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Terrani, Kurt A [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Nelson, Andrew [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Parker, Scott [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Parkison, Adam [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2013-12-23

    The Fuel Cycle Research and Development (FCRD) program’s Advanced Fuels Campaign has initiated a multifold effort aimed at facilitating development of accident tolerant fuels in order to overcome the inherent shortcomings of light water reactor (LWR) fuels when exposed to beyond design basis accident conditions. The campaign has invested in development of experimental infrastructure within the Department of Energy complex capable of chronicling the performance of a wide range of concepts under prototypic accident conditions. This report summarizes progress made at Oak Ridge National Laboratory (ORNL) and Los Alamos National Laboratory (LANL) in FY13 toward these goals. Alternative fuel cladding materials to Zircaloy for accident tolerance and a significantly extended safety margin requires oxidation resistance to steam or steam-H2 environments at ≥1200°C for short times. At ORNL, prior work focused attention on SiC, FeCr and FeCrAl as the most promising candidates for further development. Also, it was observed that elevated pressure and H2 additions had minor effects on alloy steam oxidation resistance, thus, 1 bar steam was adequate for screening potential candidates. Commercial Fe-20Cr-5Al alloys remain protective up to 1475°C in steam and CVD SiC up to 1700°C in steam. Alloy development has focused on Fe-Cr-Mn-Si-Y and Fe-Cr-Al-Y alloys with the aluminaforming alloys showing more promise. At 1200°C, ferritic binary Fe-Cr alloys required ≥25% Cr to be protective for this application. With minor alloy additions to Fe-Cr, more than 20%Cr was still required, which makes the alloy susceptible to α’ embrittlement. Based on current results, a Fe-15Cr-5Al-Y composition was selected for initial tube fabrication and welding for irradiation experiments in FY14. Evaluations of chemical vapor deposited (CVD) SiC were conducted up to 1700°C in steam. The reaction of H2O with the alumina reaction tube at 1700°C resulted in Al(OH)3

  8. An overview of changes in pressure values of the middle ear using impedance audiometry among diver candidates in a hyperbaric chamber before and after a pressure test

    Science.gov (United States)

    Anoraga, J. S.; Bramantyo, B.; Bardosono, S.; Simanungkalit, S. H.; Basiruddin, J.

    2017-08-01

    Impedance audiometry is not yet routinely used in pressure tests, especially in Indonesia. Direct exposure to pressure in a hyperbaric chamber is sometimes without any assessment of the middle ear or the Eustachian tube function (ETF) of ventilation. Impedance audiometry examinations are important to assess ETF ventilation. This study determined the middle ear pressure value changes associated with the ETF (ventilation) of prospective divers. This study included 29 prospective divers aged 20-40 years without conductive hearing loss. All subjects underwent a modified diving impedance audiometry examination both before and after the pressure test in a double-lock hyperbaric chamber. Using the Toynbee maneuver, the values obtained for changes of pressure in the middle ear were significant before and after the pressure test in the right and left ears: p < 0.001 and p = 0.018, respectively. The impedance audiometry examination is necessary for the selection of candidate divers undergoing pressure tests within a hyperbaric chamber.

  9. HIV-1 Immunogen: an overview of almost 30 years of clinical testing of a candidate therapeutic vaccine.

    Science.gov (United States)

    Graziani, Gina M; Angel, Jonathan B

    2016-07-01

    Although current antiretroviral therapy (ART) has transformed HIV infection into a chronic, manageable disease, ART does not cure HIV infection. Furthermore, the majority of the world's infected individuals live in resource-limited countries in which access to ART is limited. Thus, the development of an effective therapeutic HIV vaccine would be an invaluable treatment alternative. Developed by the late Dr. Jonas Salk, HIV-1 Immunogen (Remune®) is a candidate therapeutic vaccine that has been studied in thousands of HIV-infected individuals in more than a dozen clinical trials during almost three decades. This Drug Evaluation, which summarizes the results of these trials that have shown the vaccine to be safe and immunogenic, also discusses the contradictory and controversial conclusions drawn from the phases 2, 2/3 and 3 trials that assessed the clinical efficacy of this vaccine. Given the lack of unequivocal clinical benefits of HIV-1 Immunogen despite almost 30 years of extensive testing, it does not appear, in our view, that this vaccine is a clinically effective immunotherapy. However, inclusion of this vaccine in the newly proposed 'Kick/Shock and Kill' strategy for HIV eradication, or use as a prophylactic vaccine, could be considered for future trials.

  10. Test for positional candidate genes for body composition on pig chromosome 6

    Directory of Open Access Journals (Sweden)

    Pérez-Enciso Miguel

    2002-07-01

    Full Text Available Abstract One QTL affecting backfat thickness (BF, intramuscular fat content (IMF and eye muscle area (MA was previously localized on porcine chromosome 6 in an F2 cross between Iberian and Landrace pigs. This work was done to study the effect of two positional candidate genes on these traits: H-FABP and LEPR genes. The QTL mapping analysis was repeated with a regression method using genotypes for seven microsatellites and two PCR-RFLPs in the H-FABP and LEPR genes. H-FABP and LEPR genes were located at 85.4 and 107 cM respectively, by linkage analysis. The effects of the candidate gene polymorphisms were analyzed in two ways. When an animal model was fitted, both genes showed significant effects on fatness traits, the H-FABP polymorphism showed significant effects on IMF and MA, and the LEPR polymorphism on BF and IMF. But when the candidate gene effect was included in a QTL regression analysis these associations were not observed, suggesting that they must not be the causal mutations responsible for the effects found. Differences in the results of both analyses showed the inadequacy of the animal model approach for the evaluation of positional candidate genes in populations with linkage disequilibrium, when the probabilities of the parental origin of the QTL alleles are not included in the model.

  11. RESOLVED COMPANIONS OF CEPHEIDS: TESTING THE CANDIDATES WITH X-RAY OBSERVATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Nancy Remage; Pillitteri, Ignazio; Wolk, Scott; Karovska, Margarita; Tingle, Evan [Smithsonian Astrophysical Observatory, MS 4, 60 Garden St., Cambridge, MA 02138 (United States); Guinan, Edward; Engle, Scott [Department of Astronomy and Astrophysics, Villanova University, 800 Lancaster Ave., Villanova, PA 19085 (United States); Bond, Howard E. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Schaefer, Gail H. [The CHARA Array of Georgia State University, Mount Wilson, California 91023 (United States); Mason, Brian D., E-mail: nevans@cfa.harvard.edu, E-mail: heb11@psu.edu, E-mail: schaefer@chara-array.org [US Naval Observatory, 3450 Massachusetts Ave., NW, Washington, DC 20392-5420 (United States)

    2016-04-15

    We have made XMM-Newton observations of 14 Galactic Cepheids that have candidate resolved (≥5″) companion stars based on our earlier HST Wide Field Camera 3 (WFC3) imaging survey. Main-sequence stars that are young enough to be physical companions of Cepheids are expected to be strong X-ray producers in contrast to field stars. XMM-Newton exposures were set to detect essentially all companions hotter than spectral type M0 (corresponding to 0.5 M{sub ⊙}). The large majority of our candidate companions were not detected in X-rays, and hence are not confirmed as young companions. One resolved candidate (S Nor #4) was unambiguously detected, but the Cepheid is a member of a populous cluster. For this reason, it is likely that S Nor #4 is a cluster member rather than a gravitationally bound companion. Two further Cepheids (S Mus and R Cru) have X-ray emission that might be produced by either the Cepheid or the candidate resolved companion. A subsequent Chandra observation of S Mus shows that the X-rays are at the location of the Cepheid/spectroscopic binary. R Cru and also V659 Cen (also X-ray bright) have possible companions closer than 5″ (the limit for this study) which are the likely sources of X-rays. One final X-ray detection (V473 Lyr) has no known optical companion, so the prime suspect is the Cepheid itself. It is a unique Cepheid with a variable amplitude. The 14 stars that we observed with XMM constitute 36% of the 39 Cepheids found to have candidate companions in our HST/WFC3 optical survey. No young probable binary companions were found with separations of ≥5″ or 4000 au.

  12. RESOLVED COMPANIONS OF CEPHEIDS: TESTING THE CANDIDATES WITH X-RAY OBSERVATIONS

    International Nuclear Information System (INIS)

    Evans, Nancy Remage; Pillitteri, Ignazio; Wolk, Scott; Karovska, Margarita; Tingle, Evan; Guinan, Edward; Engle, Scott; Bond, Howard E.; Schaefer, Gail H.; Mason, Brian D.

    2016-01-01

    We have made XMM-Newton observations of 14 Galactic Cepheids that have candidate resolved (≥5″) companion stars based on our earlier HST Wide Field Camera 3 (WFC3) imaging survey. Main-sequence stars that are young enough to be physical companions of Cepheids are expected to be strong X-ray producers in contrast to field stars. XMM-Newton exposures were set to detect essentially all companions hotter than spectral type M0 (corresponding to 0.5 M ⊙ ). The large majority of our candidate companions were not detected in X-rays, and hence are not confirmed as young companions. One resolved candidate (S Nor #4) was unambiguously detected, but the Cepheid is a member of a populous cluster. For this reason, it is likely that S Nor #4 is a cluster member rather than a gravitationally bound companion. Two further Cepheids (S Mus and R Cru) have X-ray emission that might be produced by either the Cepheid or the candidate resolved companion. A subsequent Chandra observation of S Mus shows that the X-rays are at the location of the Cepheid/spectroscopic binary. R Cru and also V659 Cen (also X-ray bright) have possible companions closer than 5″ (the limit for this study) which are the likely sources of X-rays. One final X-ray detection (V473 Lyr) has no known optical companion, so the prime suspect is the Cepheid itself. It is a unique Cepheid with a variable amplitude. The 14 stars that we observed with XMM constitute 36% of the 39 Cepheids found to have candidate companions in our HST/WFC3 optical survey. No young probable binary companions were found with separations of ≥5″ or 4000 au

  13. Resolved Companions of Cepheids: Testing the Candidates with X-Ray Observations

    Science.gov (United States)

    Evans, Nancy Remage; Pillitteri, Ignazio; Wolk, Scott; Karovska, Margarita; Tingle, Evan; Guinan, Edward; Engle, Scott; Bond, Howard E.; Schaefer, Gail H.; Mason, Brian D.

    2016-04-01

    We have made XMM-Newton observations of 14 Galactic Cepheids that have candidate resolved (≥5″) companion stars based on our earlier HST Wide Field Camera 3 (WFC3) imaging survey. Main-sequence stars that are young enough to be physical companions of Cepheids are expected to be strong X-ray producers in contrast to field stars. XMM-Newton exposures were set to detect essentially all companions hotter than spectral type M0 (corresponding to 0.5 M⊙). The large majority of our candidate companions were not detected in X-rays, and hence are not confirmed as young companions. One resolved candidate (S Nor #4) was unambiguously detected, but the Cepheid is a member of a populous cluster. For this reason, it is likely that S Nor #4 is a cluster member rather than a gravitationally bound companion. Two further Cepheids (S Mus and R Cru) have X-ray emission that might be produced by either the Cepheid or the candidate resolved companion. A subsequent Chandra observation of S Mus shows that the X-rays are at the location of the Cepheid/spectroscopic binary. R Cru and also V659 Cen (also X-ray bright) have possible companions closer than 5″ (the limit for this study) which are the likely sources of X-rays. One final X-ray detection (V473 Lyr) has no known optical companion, so the prime suspect is the Cepheid itself. It is a unique Cepheid with a variable amplitude. The 14 stars that we observed with XMM constitute 36% of the 39 Cepheids found to have candidate companions in our HST/WFC3 optical survey. No young probable binary companions were found with separations of ≥5″ or 4000 au. Based on observations obtained with XMM-Newton, an ESA science mission with instruments and contributions directly funded by ESA Member States and the USA (NASA).

  14. Testing the Binary Hypothesis: Pulsar Timing Constraints on Supermassive Black Hole Binary Candidates

    Science.gov (United States)

    Sesana, Alberto; Haiman, Zoltán; Kocsis, Bence; Kelley, Luke Zoltan

    2018-03-01

    The advent of time domain astronomy is revolutionizing our understanding of the universe. Programs such as the Catalina Real-time Transient Survey (CRTS) or the Palomar Transient Factory (PTF) surveyed millions of objects for several years, allowing variability studies on large statistical samples. The inspection of ≈250 k quasars in CRTS resulted in a catalog of 111 potentially periodic sources, put forward as supermassive black hole binary (SMBHB) candidates. A similar investigation on PTF data yielded 33 candidates from a sample of ≈35 k quasars. Working under the SMBHB hypothesis, we compute the implied SMBHB merger rate and we use it to construct the expected gravitational wave background (GWB) at nano-Hz frequencies, probed by pulsar timing arrays (PTAs). After correcting for incompleteness and assuming virial mass estimates, we find that the GWB implied by the CRTS sample exceeds the current most stringent PTA upper limits by almost an order of magnitude. After further correcting for the implicit bias in virial mass measurements, the implied GWB drops significantly but is still in tension with the most stringent PTA upper limits. Similar results hold for the PTF sample. Bayesian model selection shows that the null hypothesis (whereby the candidates are false positives) is preferred over the binary hypothesis at about 2.3σ and 3.6σ for the CRTS and PTF samples respectively. Although not decisive, our analysis highlights the potential of PTAs as astrophysical probes of individual SMBHB candidates and indicates that the CRTS and PTF samples are likely contaminated by several false positives.

  15. Factors underlying the psychological and behavioral characteristics of Office of Strategic Services candidates: the assessment of men data revisited.

    Science.gov (United States)

    Lenzenweger, Mark F

    2015-01-01

    During World War II, the Office of Strategic Services (OSS), the forerunner of the Central Intelligence Agency, sought the assistance of clinical psychologists and psychiatrists to establish an assessment program for evaluating candidates for the OSS. The assessment team developed a novel and rigorous program to evaluate OSS candidates. It is described in Assessment of Men: Selection of Personnel for the Office of Strategic Services (OSS Assessment Staff, 1948). This study examines the sole remaining multivariate data matrix that includes all final ratings for a group of candidates (n = 133) assessed near the end of the assessment program. It applies the modern statistical methods of both exploratory and confirmatory factor analysis to this rich and highly unique data set. An exploratory factor analysis solution suggested 3 factors underlie the OSS assessment staff ratings. Confirmatory factor analysis results of multiple plausible substantive models reveal that a 3-factor model provides the best fit to these data. The 3 factors are emotional/interpersonal factors (social relations, emotional stability, security), intelligence processing (effective IQ, propaganda skills, observing and reporting), and agency/surgency (motivation, energy and initiative, leadership, physical ability). These factors are discussed in terms of their potential utility for personnel selection within the intelligence community.

  16. Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: a systematic literature search on 5 candidate biomarkers

    DEFF Research Database (Denmark)

    Syversen, Silje W; Landewe, Robert; van der Heijde, Désirée

    2009-01-01

    OBJECTIVE: To test the OMERACT 8 draft validation criteria for soluble biomarkers by assessing the strength of literature evidence in support of 5 candidate biomarkers. METHODS: A systematic literature search was conducted on the 5 soluble biomarkers RANKL, osteoprotegerin (OPG), matrix...... metalloprotease (MMP-3), urine C-telopeptide of types I and II collagen (U-CTX-I and U CTX-II), focusing on the 14 OMERACT 8 criteria. Two electronic voting exercises were conducted to address: (1) strength of evidence for each biomarker as reflecting structural damage according to each individual criterion...

  17. In-situ hot corrosion testing of candidate materials for exhaust valve spindles

    DEFF Research Database (Denmark)

    Bihlet, Uffe; Hoeg, Harro A.; Dahl, Kristian Vinter

    2011-01-01

    The two stroke diesel engine has been continually optimized since its invention more than a century ago. One of the ways to increase fuel efficiency further is to increase the compression ratio, and thereby the temperature in the combustion chamber. Because of this, and the composition of the fuel...... used, exhaust valve spindles in marine diesel engines are subjected to high temperatures and stresses as well as molten salt induced corrosion. To investigate candidate materials for future designs which will involve the HIP process, a spindle with Ni superalloy material samples inserted in a HIPd Ni49...

  18. Constructing Aligned Assessments Using Automated Test Construction

    Science.gov (United States)

    Porter, Andrew; Polikoff, Morgan S.; Barghaus, Katherine M.; Yang, Rui

    2013-01-01

    We describe an innovative automated test construction algorithm for building aligned achievement tests. By incorporating the algorithm into the test construction process, along with other test construction procedures for building reliable and unbiased assessments, the result is much more valid tests than result from current test construction…

  19. TESTING THE MAGNETAR MODEL VIA LATE-TIME RADIO OBSERVATIONS OF TWO MACRONOVA CANDIDATES

    Energy Technology Data Exchange (ETDEWEB)

    Horesh, Assaf [Benoziyo Center for Astrophysics, Weizmann Institute of Science, 76100 Rehovot (Israel); Hotokezaka, Kenta; Piran, Tsvi [Racah Institute of Physics, The Hebrew University, Jerusalem 91904 (Israel); Nakar, Ehud [Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978 (Israel); Hancock, Paul [International Centre for Radio Astronomy Research (ICRAR), Curtin University, GPO Box U1987, Perth WA 6845 (Australia)

    2016-03-10

    Compact binary mergers may have already been observed as they are the leading model for short gamma-ray bursts (sGRBs). Radioactive decay within the ejecta from these mergers is expected to produce an infrared flare, dubbed macronova (or kilonova), on a timescale of a week. Recently, two such macronova candidates were identified in followup observations of sGRBs, strengthening the possibility that those indeed arise from mergers. The same ejecta will also produce long-term (months to years) radio emission due to its interaction with the surrounding interstellar medium. In the search for this emission, we observed the two macronova candidates, GRB 130603B and GRB 060614, with the Jansky Very Large Array (VLA) and the Australia Telescope Compact Array (ATCA). Our observations resulted in null-detections, putting strong upper limits on the kinetic energy and mass of the ejecta. A possible outcome of a merger is a highly magnetized neutron star (a magnetar), which has been suggested as the central engine for GRBs. Such a magnetar will deposit a significant fraction of its energy into the ejecta leading to a brighter radio flare. Our results, therefore, rule out magnetars in these two events.

  20. The Cognitive Processing of Candidates during Reading Tests: Evidence from Eye-Tracking

    Science.gov (United States)

    Bax, Stephen

    2013-01-01

    The research described in this article investigates test takers' cognitive processing while completing onscreen IELTS (International English Language Testing System) reading test items. The research aims, among other things, to contribute to our ability to evaluate the cognitive validity of reading test items (Glaser, 1991; Field, in press). The…

  1. Hemodynamic exercise testing. A valuable tool in the selection of cardiac transplantation candidates.

    Science.gov (United States)

    Chomsky, D B; Lang, C C; Rayos, G H; Shyr, Y; Yeoh, T K; Pierson, R N; Davis, S F; Wilson, J R

    1996-12-15

    Peak exercise oxygen consumption (Vo2), a noninvasive index of peak exercise cardiac output (CO), is widely used to select candidates for heart transplantation. However, peak exercise Vo2 can be influenced by noncardiac factors such as deconditioning, motivation, or body composition and may yield misleading prognostic information. Direct measurement of the CO response to exercise may avoid this problem and more accurately predict prognosis. Hemodynamic and ventilatory responses to maximal treadmill exercise were measured in 185 ambulatory patients with chronic heart failure who had been referred for cardiac transplantation (mean left ventricular ejection fraction, 22 +/- 7%; mean peak Vo2, 12.9 +/- 3.0 mL. min-1.kg-1). CO response to exercise was normal in 83 patients and reduced in 102. By univariate analysis, patients with normal CO responses had a better 1-year survival rate (95%) than did those with reduced CO responses (72%) (P 14 mL.min-1.kg-1 (88%) was not different from that of patients with peak Vo2 of 10 mL.min-1.kg-1 (89%) (P < .0001). By Cox regression analysis, exercise CO response was the strongest independent predictor of survival (risk ratio, 4.3), with peak Vo2 dichotomized at 10 mL. min-1.kg-1 (risk ratio, 3.3) as the only other independent predictor. Patients with reduced CO responses and peak Vo2 of < or = 10 mL.min-1.kg-1 had an extremely poor 1-year survival rate (38%). Both CO response to exercise and peak exercise Vo2 provide valuable independent prognostic information in ambulatory patients with heart failure. These variables should be used in combination to select potential heart transplantation candidates.

  2. Quality assessment of organic coffee beans for the preparation of a candidate reference material

    International Nuclear Information System (INIS)

    Tagliaferro, F.S.; Nadai Fernandes de, E.A.; Bacchi, M.A.

    2006-01-01

    A random sampling was carried out in the coffee beans collected for the preparation of the organic green coffee reference material in view of assessing the homogeneity and the presence of soil as impurity. Fifteen samples were taken for the between-sample homogeneity evaluation. One of the samples was selected and 10 test portions withdrawn for the within-sample homogeneity evaluation. Br, Ca, Co, Cs, Fe, K, Na, Rb, Sc and Zn were determined by instrumental neutron activation analysis (INAA). The F-test demonstrated that the material is homogeneous for Ca, Co, Cs, K and Sc, but not homogeneous for Br, Fe, Na, Rb and Zn. Results of terrigenous elements suggested negligible soil contamination in the raw material. (author)

  3. An Assessment of IELTS Speaking Test

    Science.gov (United States)

    Karim, Shahzad; Haq, Naushaba

    2014-01-01

    The present study focused on assessing the speaking test of IELTS. The assessment discussed both positive aspects and weaknesses in IELTS speaking module. The researchers had also suggested some possible measures for the improvement in IELTS speaking test and increasing its validity and reliability. The researchers had analysed and assessed IELTS…

  4. Evaluation of candidate magnetohydrodynamic materials for the U-02 Phase III test

    International Nuclear Information System (INIS)

    Marchant, D.D.; Bates, J.L.

    1978-06-01

    As part of a cooperative U.S.--U.S.S.R. program, electrode and insulator materials tested at the Westinghouse Electrode Systems Test Facility in Pittsburgh, Pennsylvania, were evaluated. From this evaluation materials will be selected for use in the third phase of tests being conducted in the U-02 magnetohydrodynamics test facility in the Soviet Union. Electrode and insulator materials were examined with both an optical microscope and a scanning electron microscope. The cathodes were found to behave differently from the anodes; most notably, the cathodes showed greater potassium interaction. The lanthanum chromite-based electrodes (excluding those fabricated by plasma-spraying) are recommended for testing in the U-02 Phase III test. Hotpressed, fused-grained MgO and sintered MgAl 2 O 4 are recommended as insulator materials. The electrode attachment techniques used in the Westinghouse Tests were inadequate and need to be modified for the U-02 test

  5. Dealing with differences: The impact of perceived diversity outcomes on selection and assessment of minority candidates

    NARCIS (Netherlands)

    Hofhuis, J.; van der Zee, K.I.; Otten, S.

    2016-01-01

    Although many strategies have been employed to specifically recruit and select minority employees, the selection rates for designated minority groups are often lower than those for the majority group. Minority candidates with high cultural maintenance (CM) are particularly vulnerable to cultural

  6. Dealing with differences : the impact of perceived diversity outcomes on selection and assessment of minority candidates

    NARCIS (Netherlands)

    Hofhuis, Joep; van der Zee, Karen I.; Otten, Sabine

    2016-01-01

    Although many strategies have been employed to specifically recruit and select minority employees, the selection rates for designated minority groups are often lower than those for the majority group. Minority candidates with high cultural maintenance (CM) are particularly vulnerable to cultural

  7. Wear Test Results of Candidate Materials for the OK-542 Towed Array Handling Machine Level Winder

    Science.gov (United States)

    1994-12-29

    10 6. Wear Testing Photograph B ....................................................... .11 7. Clad Inconel 625 ...interfere with this wear test. Other materials that were tested included Inconel 625 , Titanium, 304 Stainless, 316 Stainless, and Ni-Al-Br. All of these...Stainless Steel, Inconel 625 , Nickel-Aluminum-Bronze, and Titanium. The specialty materials: Inconel 625 , Monel, Stainless and Stellite, were clad-welded

  8. Do candidate reactions relate to job performance or affect criterion-related validity? A multistudy investigation of relations among reactions, selection test scores, and job performance.

    Science.gov (United States)

    McCarthy, Julie M; Van Iddekinge, Chad H; Lievens, Filip; Kung, Mei-Chuan; Sinar, Evan F; Campion, Michael A

    2013-09-01

    Considerable evidence suggests that how candidates react to selection procedures can affect their test performance and their attitudes toward the hiring organization (e.g., recommending the firm to others). However, very few studies of candidate reactions have examined one of the outcomes organizations care most about: job performance. We attempt to address this gap by developing and testing a conceptual framework that delineates whether and how candidate reactions might influence job performance. We accomplish this objective using data from 4 studies (total N = 6,480), 6 selection procedures (personality tests, job knowledge tests, cognitive ability tests, work samples, situational judgment tests, and a selection inventory), 5 key candidate reactions (anxiety, motivation, belief in tests, self-efficacy, and procedural justice), 2 contexts (industry and education), 3 continents (North America, South America, and Europe), 2 study designs (predictive and concurrent), and 4 occupational areas (medical, sales, customer service, and technological). Consistent with previous research, candidate reactions were related to test scores, and test scores were related to job performance. Further, there was some evidence that reactions affected performance indirectly through their influence on test scores. Finally, in no cases did candidate reactions affect the prediction of job performance by increasing or decreasing the criterion-related validity of test scores. Implications of these findings and avenues for future research are discussed. PsycINFO Database Record (c) 2013 APA, all rights reserved

  9. Stress-corrosion cracking properties of candidate fuel cladding alloys for the Canadian SCWR: a summary of literature data and recent test results

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, W.; Zeng, Y., E-mail: Wenyue@NRcan.gc.ca [CanmetMATERIALS, Hamilton, ON (Canada); Luo, J. [Univ. of Alberta, Edmonton, AB (Canada); Novotny, R. [JRC-European Commission, Patten (Netherlands); Li, J.; Amirkhiz, B.S., E-mail: Jian.li@nrcan.gc.ca [CanmetMATERIALS, Hamilton, ON (Canada); Guzonas, D. [Atomic Energy of Canada Limited, Chalk River, ON (Canada); Matchim, M.; Collier, J.; Yang, L., E-mail: lin.yang@nrcan.gc.ca [CanmetMATERIALS, Hamilton, ON (Canada)

    2014-07-01

    Cracking of fuel claddings is a serious concern when selecting candidate alloys for the development of a next-generation reactor. Whether the cracking is due to an environment-metal interaction such as stress-corrosion, or a pure metallurgical process such as localized plastic deformation along grain boundaries, the final impact is the same: cracking of the cladding can lead to fuel failure. In the course of a review of potential candidate alloys in preparation for further assessment under conditions relevant to the Canadian SCWR concept, relevant cracking studies reported for five short-listed alloys (namely 310S, 347H, 800H, 625 and 214) in the open literature were examined, and the key findings are provided in this paper. Discussions are also made of the recent SCC data from capsule tests and slow-strain rate tests (SSRT) in supercritical water. The data suggest that there is a threshold strain level below which SCC is not developed during SSRT tests. The practical implication of this finding is also discussed. (author)

  10. Aircraft Assessment and Acceptance Testing.

    Science.gov (United States)

    1980-05-01

    telaque le pilote automatique, et lautomnanette, lee syst.-mes de stabilit6 artificielle etc.. A5 - La v~rification des dispositifs de odcuritd B - Essais...signals should be monitored on an oscilloscope, and modulation meter to assist in diagnosis or reasons for poor intelligibility . 7 Qualitative...conditioning in origin, so tests of the effect on com- munications intelligibility should be made in the flight regime that is operationally most

  11. Assessment of candidate sites for disposal of treated effluents at the Hanford Site, Washington

    International Nuclear Information System (INIS)

    Davis, J.D.

    1992-01-01

    A rigidly defined evaluation process was used to recommend a preferred location to dispose of treated effluents from facilities in the 200 Areas of the US Department of Energy's Hanford Site in Washington State. First, siting constraints were defined based on functional design considerations and siting guidelines. Then, criteria for selecting a preferred site from among several candidates were identified and their relative importance defined. Finally, the weighted criteria were applied and a site was selected for detailed characterization by subsurface investigations

  12. Functional loading test for expert estimation of health candidates in cosmonauts (the innovative approach)

    Science.gov (United States)

    Voronkov, Yury; Skedina, Marina; Degterenkova, Natalia; Stepanova, Galina

    Long stay of cosmonauts in conditions of International Space Station demands the increased medical control over their health during selection. Various parameters of cardiovascular system (CVS) undergo significant changes both during adaptation to space flight (period of removing into an orbit), directly under conditions of weightlessness and during readaptation to terrestrial environment. The CVS is sensitive indicator of adaptation reaction of total organism. Therefore much attention is given to the research of CVS regulation, its opportunities to adapt to various stress conditions, detection of pre-nozological changes in mechanisms of its regulation. One of the informative methods for detecting problems in CVS regulation is a postural orthostatic test. This work was designed to research regulation of hemodynamics during passive orthostatic test. 21 practically healthy people in the age from 18 to 36 years old have passed the test. During test the following parameters were registered: 12 Lead ECG and the BP, parameters of a myocardium by means of "CardioVisor-06" (CV) device, and also a condition of microcirculatory bloodstream (MCB) was estimated by means of ultrasonic high-frequency dopplerograph "Minimax-Doppler-K" with 20 MHz sensor. The impedance method of rheoencephalography (REG) by means of the "Encephalan-EEGR-13103" device was used to research a cerebral blood circulation. All subjects had normal parameters of ECG during test. However, during analysis data of CV, REG and MCB high tolerability to the test was observed in 14 test subjects. In other 7 subjects dynamics of parameters during test reflected problems in mechanisms of CVS regulation in its separate parts. Changes in parameters of REG and ultrasound in 4 test subjects reflected a hypotensive reaction. The parameter of a tone of arterioles in carotid and vertebral arteries system decreased for 15,3 % and 55,2 % accordingly. The parameters of MCB: average speed, vascular tone and peripheric

  13. Laboratory corrosion tests on candidate high-level waste container materials: Results from the Belgian programme

    International Nuclear Information System (INIS)

    Druyts, F.; Kursten, B.; Iseghem, P. Van

    2004-01-01

    The Belgian SAFIR-2 concept foresees the geological disposal of conditioned high-level radioactive waste in stainless steel containers and overpacks placed in a concrete gallery backfilled with Boom clay or a bentonite-type backfill. In addition to earlier in situ experiments, we used a laboratory approach to investigate the corrosion properties of selected stainless steels in Boom clay and bentonite environments. In the SAFIR-2 concept, AISI 316L hMo is the main candidate overpack material. As an alternative, we also investigated the higher alloyed stainless steel UHB 904L. Our study focused on localised corrosion and in particular pitting. We used cyclic potentiodynamic polarisation measurements to determine the pit nucleation potential E NP and the protection potential E PP . The evolution of the corrosion potential with time was determined by monitoring the open circuit potential in synthetic clay-water over extended periods. In this paper we present and discuss some results from our laboratory programme, focusing on long-term interactions between the stainless steel overpack and the backfill materials. We describe in particular the influence of chloride and thio-sulphate ions on the pitting corrosion behaviour. The results show that, under geochemical conditions typical for geological disposal, i.e. [Cl-] ∼ 30 mg/L for a Boom clay backfill and [Cl-] ∼ 90 mg/L for a bentonite backfill, neither AISI 316L hMo nor UHB 904L is expected to present pitting problems. An important factor in the long-term prediction of the corrosion behaviour however, is the robustness of the model for the evolution of the geochemistry of the backfill. Indeed, at chloride levels higher than 1000 mg/L, we predict pitting corrosion for AISI 316L hMo. (authors)

  14. Transit timing observations from Kepler. VI. Potentially interesting candidate systems from fourier-based statistical tests

    DEFF Research Database (Denmark)

    Steffen, J.H.; Ford, E.B.; Rowe, J.F.

    2012-01-01

    We analyze the deviations of transit times from a linear ephemeris for the Kepler Objects of Interest (KOI) through quarter six of science data. We conduct two statistical tests for all KOIs and a related statistical test for all pairs of KOIs in multi-transiting systems. These tests identify...... several systems which show potentially interesting transit timing variations (TTVs). Strong TTV systems have been valuable for the confirmation of planets and their mass measurements. Many of the systems identified in this study should prove fruitful for detailed TTV studies....

  15. TRANSIT TIMING OBSERVATIONS FROM KEPLER. VI. POTENTIALLY INTERESTING CANDIDATE SYSTEMS FROM FOURIER-BASED STATISTICAL TESTS

    International Nuclear Information System (INIS)

    Steffen, Jason H.; Ford, Eric B.; Rowe, Jason F.; Borucki, William J.; Bryson, Steve; Caldwell, Douglas A.; Jenkins, Jon M.; Koch, David G.; Sanderfer, Dwight T.; Seader, Shawn; Twicken, Joseph D.; Fabrycky, Daniel C.; Holman, Matthew J.; Welsh, William F.; Batalha, Natalie M.; Ciardi, David R.; Kjeldsen, Hans; Prša, Andrej

    2012-01-01

    We analyze the deviations of transit times from a linear ephemeris for the Kepler Objects of Interest (KOI) through quarter six of science data. We conduct two statistical tests for all KOIs and a related statistical test for all pairs of KOIs in multi-transiting systems. These tests identify several systems which show potentially interesting transit timing variations (TTVs). Strong TTV systems have been valuable for the confirmation of planets and their mass measurements. Many of the systems identified in this study should prove fruitful for detailed TTV studies.

  16. Formulation of a candidate glass for use as an acceptance test standard material

    International Nuclear Information System (INIS)

    Ebert, W.L.; Strachan, D.M.; Wolf, S.F.

    1998-04-01

    In this report, the authors discuss the formulation of a glass that will be used in a laboratory testing program designed to measure the precision of test methods identified in the privatization contracts for the immobilization of Hanford low-activity wastes. Tests will be conducted with that glass to measure the reproducibility of tests and analyses that must be performed by glass producers as a part of the product acceptance procedure. Test results will be used to determine if the contractually required tests and analyses are adequate for evaluating the acceptability of likely immobilized low-activity waste (ILAW) products. They will also be used to evaluate if the glass designed for use in these tests can be used as an analytical standard test material for verifying results reported by vendors for tests withg ILAW products. The results of those tests and analyses will be presented in a separate report. The purpose of this report is to document the strategy used to formulate the glass to be used in the testing program. The low-activity waste reference glass LRM that will be used in the testing program was formulated to be compositionally similar to ILAW products to be made with wastes from Hanford. Since the ILAW product compositions have not been disclosed by the vendors participating in the Hanford privatization project, the composition of LRM was formulated based on simulated Hanford waste stream and amounts of added glass forming chemicals typical for vitrified waste forms. The major components are 54 mass % SiO 2 , 20 mass % Na 2 O, 10 mass % Al 2 O 3 , 8 mass % B 2 O 3 , and 1.5 mass % K 2 O. Small amounts of other chemicals not present in Hanford wastes were also included in the glass, since they may be included as chemical additives in ILAW products. This was done so that the use of LRM as a composition standard could be evaluated. Radionuclides were not included in LRM because a nonradioactive material was desired

  17. Nevada Test Site Wetlands Assessment

    Energy Technology Data Exchange (ETDEWEB)

    D. J. Hansen

    1997-05-01

    This report identifies 16 Nevada Test Site (NTS) natural water sources that may be classified by the U.S. Army Corps of Engineers (USACE) as jurisdictional wetlands and identifies eight water sources that may be classified as waters of the United States. These water sources are rare, localized habitats on the NTS that are important to regional wildlife and to isolated populations of water tolerant plants and aquatic organisms. No field investigations on the NTS have been conducted in the past to identify those natural water sources which would be protected as rare habitats and which may fall under regulatory authority of the Clean Water Act (CWA) of 1997. This report identifies and summarizes previous studies of NTS natural water sources, and identifies the current DOE management practices related to the protection of NTS wetlands. This report also presents management goals specific for NTS wetlands that incorporate the intent of existing wetlands legislation, the principles of ecosystem management, and the interests of regional land managers and other stakeholders.

  18. Assessment of Candidal carriage in patients with Type II Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    RS Lamichhane

    2015-03-01

    Full Text Available Background: It is generally acknowledged that patients with diabetes mellitus are more susceptible to fungal infections, particularly with Candida albicans. Oral infection by Candida can result in a number of clinical lesions, including median rhomboid glossitis (central papillary atrophy, denture stomatitis, squamous cell carcinoma, Radiation therapy, immunocompromised status, etc. Different studies have shown that patients with diabetes mellitus have increased frequency of oral candidal carriage and increased risk of candidiasis, which is related to poor metabolic control, neutrophil dysfunction, reduced salivary flow, high glucose concentration in blood and saliva and in medications.Materials and Methods: Subjects of both the groups were given 10 ml of sterile normal saline and asked to rinse the mouth for one minute. The subjects were then asked to return the oral rinse in a sterile clean, broad-mouthed container which was capped, labelled and taken to the laboratory. The samples were then inoculated onto the culture medium (Sabouraud’s dextrose agar with Chloramphenicol with minimal delay (within 6-8 hours of collection of oral rinse. Candidal colonies were counted and compared with non-diabetics.Results: Statistically significant increase in colony forming units (p=0.0324 were obtainedin patients with diabetes mellitus.Conclusion: The results indicate significant increase in colonization and carriage of candida in the oral cavity among diabetics when compared with non-diabetics. However, further research using larger samples is required which may lend credibility to the suggestion of increased candidal CFUs in diabetics serving as a surrogate marker of serum glucose levels.Journal of Pathology of Nepal (2015 Vol. 5, 733-738

  19. Evaluation of the biomarker candidate MFAP4 for non-invasive assessment of hepatic fibrosis in hepatitis C patients.

    Science.gov (United States)

    Bracht, Thilo; Mölleken, Christian; Ahrens, Maike; Poschmann, Gereon; Schlosser, Anders; Eisenacher, Martin; Stühler, Kai; Meyer, Helmut E; Schmiegel, Wolff H; Holmskov, Uffe; Sorensen, Grith L; Sitek, Barbara

    2016-07-04

    The human microfibrillar-associated protein 4 (MFAP4) is located to extracellular matrix fibers and plays a role in disease-related tissue remodeling. Previously, we identified MFAP4 as a serum biomarker candidate for hepatic fibrosis and cirrhosis in hepatitis C patients. The aim of the present study was to elucidate the potential of MFAP4 as biomarker for hepatic fibrosis with a focus on the differentiation of no to moderate (F0-F2) and severe fibrosis stages and cirrhosis (F3 and F4, Desmet-Scheuer scoring system). MFAP4 levels were measured using an AlphaLISA immunoassay in a retrospective study including n = 542 hepatitis C patients. We applied a univariate logistic regression model based on MFAP4 serum levels and furthermore derived a multivariate model including also age and gender. Youden-optimal cutoffs for binary classification were determined for both models without restrictions and considering a lower limit of 80 % sensitivity (correct classification of F3 and F4), respectively. To assess the generalization error, leave-one-out cross validation (LOOCV) was performed. MFAP4 levels were shown to differ between no to moderate fibrosis stages F0-F2 and severe stages (F3 and F4) with high statistical significance (t test on log scale, p value <2.2·10(-16)). In the LOOCV, the univariate classification resulted in 85.8 % sensitivity and 54.9 % specificity while the multivariate model yielded 81.3 % sensitivity and 61.5 % specificity (restricted approaches). We confirmed the applicability of MFAP4 as a novel serum biomarker for assessment of hepatic fibrosis and identification of high-risk patients with severe fibrosis stages in hepatitis C. The combination of MFAP4 with existing tests might lead to a more accurate non-invasive diagnosis of hepatic fibrosis and allow a cost-effective disease management in the era of new direct acting antivirals.

  20. High-throughput testing of terpenoid biosynthesis candidate genes using transient expression in Nicotiana benthamiana

    DEFF Research Database (Denmark)

    Bach, Søren Spanner; Bassard, Jean-Étienne André; Andersen-Ranberg, Johan

    2014-01-01

    To respond to the rapidly growing number of genes putatively involved in terpenoid metabolism, a robust high-throughput platform for functional testing is needed. An in planta expression system offers several advantages such as the capacity to produce correctly folded and active enzymes localized...

  1. Application of miniaturized disk bend test technique for selection of optimum composition of candidate materials for fusion reactors

    International Nuclear Information System (INIS)

    Tsepelev, A.B.; Poymenov, I.L.

    1992-01-01

    An analysis of the potential of a miniaturized disk bend test (MDBT) technique for estimation of irradiated steel mechanical properties behaviour indicates promise in selecting candidate materials for nuclear applications. The advantages of the method are most clearly demonstrated when a large series of tests is needed. The tiny specimen size gives an additional advantage from the point of view of radiation material science. As an example of the MDBT potential, preliminary results of electron irradiation effects on Cr-Mn-W austenitic and Cr-W ferrite carbon and nitrogen steels are presented. It is shown that electron irradiation causes changes of the loading MDBT-curve form of the steels that most probably are connected with radiation-induced structure-phase transformations in the steels. (orig.)

  2. PROGRAM ASTEC (ADVANCED SOLAR TURBO ELECTRIC CONCEPT). PART 1. CANDIDATE MATERIALS LABORATORY TESTS

    Science.gov (United States)

    A space power system of the type envisioned by the ASTEC program requires the development of a lightweight solar collector of high reflectance...capable of withstanding the space environment for an extended period. A survey of the environment of interest for ASTEC purposes revealed 4 potential...developed by the solar-collector industry for use in the ASTEC program, and to test the effects of space environment on these materials. Of 6 material

  3. Accuracy of computer-calculated and manual QRS duration assessments: Clinical implications to select candidates for cardiac resynchronization therapy.

    Science.gov (United States)

    De Pooter, Jan; El Haddad, Milad; Stroobandt, Roland; De Buyzere, Marc; Timmermans, Frank

    2017-06-01

    QRS duration (QRSD) plays a key role in the field of cardiac resynchronization therapy (CRT). Computer-calculated QRSD assessments are widely used, however inter-manufacturer differences have not been investigated in CRT candidates. QRSD was assessed in 377 digitally stored ECGs: 139 narrow QRS, 140 LBBB and 98 ventricular paced ECGs. Manual QRSD was measured as global QRSD, using digital calipers, by two independent observers. Computer-calculated QRSD was assessed by Marquette 12SL (GE Healthcare, Waukesha, WI, USA) and SEMA3 (Schiller, Baar, Switzerland). Inter-manufacturer differences of computer-calculated QRSD assessments vary among different QRS morphologies: narrow QRSD: 4 [2-9] ms (median [IQR]), p=0.010; LBBB QRSD: 7 [2-10] ms, p=0.003 and paced QRSD: 13 [6-18] ms, p=0.007. Interobserver differences of manual QRSD assessments measured: narrow QRSD: 4 [2-6] ms, p=non-significant; LBBB QRSD: 6 [3-12] ms, p=0.006; paced QRSD: 8 [4-18] ms, p=0.001. In LBBB ECGs, intraclass correlation coefficients (ICCs) were comparable for inter-manufacturer and interobserver agreement (ICC 0.830 versus 0.837). When assessing paced QRSD, manual measurements showed higher ICC compared to inter-manufacturer agreement (ICC 0.902 versus 0.776). Using guideline cutoffs of 130ms, up to 15% of the LBBB ECGs would be misclassified as <130ms or ≥130ms by at least one method. Using a cutoff of 150ms, this number increases to 33% of ECGs being misclassified. However, by combining LBBB-morphology and QRSD, the number of misclassified ECGs can be decreased by half. Inter-manufacturer differences in computer-calculated QRSD assessments are significant and may compromise adequate selection of individual CRT candidates when using QRSD as sole parameter. Paced QRSD should preferentially be assessed by manual QRSD measurements. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Fireside corrosion testing of candidate superheater tube alloys, coatings, and claddings -- Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Blough, J.L.; Seitz, W.W. [Foster Wheeler Development Corp., Livingston, NJ (United States)

    1997-12-01

    In Phase 1 a variety of developmental and commercial tubing alloys and claddings were exposed to laboratory fireside corrosion testing simulating a superheater or reheater in a coal-fired boiler. Phase 2 (in situ testing) has exposed samples of 347 RA-85H, HR3C, 253MA, Fe{sub 3}Al + 5Cr, 310 Ta modified, NF 709, 690 clad, and 671 clad for approximately 4,000, 12,000, and 16,000 hours to the actual operating conditions of a 250-MW coal-fired boiler. The samples were assembled on an air-cooled, retractable corrosion probe, the probe was installed in the reheater activity of the boiler and controlled to the operating metal temperatures of an existing and advanced-cycle coal-fired boiler. The results will be presented for the preliminary metallurgical examination of the corrosion probe samples after 16,000 hours of exposure. Continued metallurgical and interpretive analysis is still on going.

  5. The Predictive Power of the Self-Efficacy Beliefs of Physical Education Candidate Teachers on Their Attitudes towards the Assessment and Evaluation in Education

    Science.gov (United States)

    Varol, Yaprak Kalemoglu

    2016-01-01

    The aim of the research is to examine relationship between self-efficacy beliefs and attitudes for assessment and evaluation of physical education candidate teachers. In this research, the relational model has been used. Study group consists of 86 women (48%), 93 men (52%) and total 179 physical education teacher candidates (M[subscript age] =…

  6. Advanced Test Reactor probabilistic risk assessment

    International Nuclear Information System (INIS)

    Atkinson, S.A.; Eide, S.A.; Khericha, S.T.; Thatcher, T.A.

    1993-01-01

    This report discusses Level 1 probabilistic risk assessment (PRA) incorporating a full-scope external events analysis which has been completed for the Advanced Test Reactor (ATR) located at the Idaho National Engineering Laboratory

  7. Early Phonological Development: Creating an Assessment Test

    Science.gov (United States)

    Stoel-Gammon, Carol; Williams, A. Lynn

    2013-01-01

    This paper describes a new protocol for assessing the phonological systems of two-year-olds with typical development and older children with delays in vocabulary acquisition. The test (Profiles of Early Expressive Phonological Skills ("PEEPS"), Williams & Stoel-Gammon, in preparation) differs from currently available assessments in…

  8. Validation of biomarkers of food intake − critical assessment of candidate biomarkers

    DEFF Research Database (Denmark)

    Dragsted, Lars Ove; Gao, Qian; Scalbert, Augustin

    2018-01-01

    Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promis...

  9. An assessment of enterotoxigenic Escherichia coli and Shigella vaccine candidates for infants and children.

    Science.gov (United States)

    Walker, Richard I

    2015-02-18

    Despite improvements to water quality, sanitation, and the implementation of current prevention and treatment interventions, diarrhea remains a major cause of illness and death, especially among children less than five years of age in the developing world. Rotavirus vaccines have already begun making a real impact on diarrhea, but several more enteric vaccines will be necessary to achieve broader reductions of illness and death. Among the many causes of diarrheal disease, enterotoxigenic Escherichia coli (ETEC) and Shigella are the two most important bacterial pathogens for which there are no currently licensed vaccines. Vaccines against these two pathogens could greatly reduce the impact of disease caused by these infections. This review describes the approaches to ETEC and Shigella vaccines that are currently under development, including a range of both cellular and subunit approaches for each pathogen. In addition, the review discusses strategies for maximizing the potential benefit of these vaccines, which includes the feasibility of co-administration, consolidation, and combination of vaccine candidates, as well as issues related to effective administration of enteric vaccines to infants. Recent impact studies indicate that ETEC and Shigella vaccines could significantly benefit global public health. Either vaccine, particularly if they could be combined together or with another enteric vaccine, would be an extremely valuable tool for saving lives and promoting the health of infants and children in the developing world, as well as potentially providing protection to travelers and military personnel visiting endemic areas. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector ▿

    Science.gov (United States)

    Stoeker, Laura; Nordone, Shila; Gunderson, Sara; Zhang, Lin; Kajikawa, Akinobu; LaVoy, Alora; Miller, Michael; Klaenhammer, Todd R.; Dean, Gregg A.

    2011-01-01

    Lactobacillus species are commensal bacteria that have long been recognized as probiotic microbes and are generally regarded as safe (GRAS) for human consumption. We have investigated the use of L. gasseri as a vaccine vector for oral immunization against mucosal pathogens. Recent research has shown that the immune response to different lactobacilli can vary widely depending on the species or subspecies of Lactobacillus being studied. While some lactobacilli seem to induce oral tolerance, others induce an adaptive immune response. This study characterized the systemic and mucosal immune response to wild-type and genetically modified L. gasseri. L. gasseri primarily activates TLR2/6, with additional activation through the TLR2 homodimer. To expand the Toll-like receptor (TLR) activation profile of L. gasseri and the immunogenicity of the vector, a plasmid containing fliC, the gene encoding bacterial flagellin, was introduced which resulted in the strong activation of TLR5. The treatment of human myeloid dendritic cells with recombinant lactobacilli expressing flagellin triggered phenotypic maturation and the release of proinflammatory cytokines. In contrast, bacterial treatment also resulted in a statistically significant increase in IL-10 production. In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon. Furthermore, treatment with genetically modified L. gasseri led to a significant decrease in the percentage of FoxP3+ colonic lymphocytes. Taken together, these data clarify the interaction of L. gasseri with the host immune system and support further investigation of the in vivo immunogenicity of L. gasseri expressing both flagellin and candidate vaccine antigens. PMID:21900526

  11. How to assess good candidate molecules for self-activated optical power limiting

    Science.gov (United States)

    Lundén, Hampus; Glimsdal, Eirik; Lindgren, Mikael; Lopes, Cesar

    2018-03-01

    Reverse saturable absorbers have shown great potential to attenuate laser radiation. Good candidate molecules and various particles have successfully been incorporated into different glass matrices, enabling the creation of self-activated filters against damaging laser radiation. Although the performance of such filters has been impressive, work is still ongoing to improve the performance in a wider range of wavelengths and pulse widths. The purpose of this tutorial is, from an optical engineering perspective, to give an understanding of the strengths and weaknesses of this class of smart materials, how relevant photophysical parameters are measured and influence system performance and comment on the pitfalls in experimental evaluation of materials. A numerical population model in combination with simple physical formulas is used to demonstrate system behavior from a performance standpoint. Geometrical reasoning shows the advantage of reverse saturable absorption over nonlinear scattering due to a fraction of scattered light being recollected by imaging system optics. The numerical population model illustrates the importance of the optical power limiting performance during the leading edge of a nanosecond pulse, which is most strongly influenced by changes in the two-photon absorption cross section and the triplet linear absorption cross section for a modeled Pt-acetylide. This tutorial not only targets optical engineers evaluating reverse saturable absorbing materials but also aims to assist researchers with a chemistry background working on optical power limiting materials. We also present photophysical data for a series of coumarins that can be useful for the determination of quantum yields and two-photon cross sections and show examples of characterization of molecules with excited triplet states.

  12. Factor Structure and Reliability of Test Items for Saudi Teacher Licence Assessment

    Science.gov (United States)

    Alsadaawi, Abdullah Saleh

    2017-01-01

    The Saudi National Assessment Centre administers the Computer Science Teacher Test for teacher certification. The aim of this study is to explore gender differences in candidates' scores, and investigate dimensionality, reliability, and differential item functioning using confirmatory factor analysis and item response theory. The confirmatory…

  13. 78 FR 14111 - Final Candidate Conservation Agreement With Assurances, Final Environmental Assessment, and...

    Science.gov (United States)

    2013-03-04

    ... Finding of No Significant Impact; Lesser Prairie Chicken, Oklahoma AGENCY: Fish and Wildlife Service... assessment (EA) and the draft Finding of No Significant Impact (FONSI) under the National Environmental... in Alfalfa, Beaver, Beckham, Cimarron, Custer, Dewey, Ellis, Harper, Major, Roger Mills, Texas...

  14. Diagnostic Vocational Assessment for Special Needs Student Candidates for Vocational Training.

    Science.gov (United States)

    Blackstone Valley Regional Vocational School District, Upton, MA.

    A project was conducted to bridge the gap between the coneptualized model of vocational evaluation within a rehabilitation framework and the needs of a changing career development model within an educational setting. The project focus was on ascertaining the state of the art of vocational assessment of special needs individuals, then building a…

  15. Quality of assessment of prior learning in university programmes : Perceptions of candidates, tutors and assessors

    NARCIS (Netherlands)

    Desirée Joosten-ten Brinke; W. Jochems; Dominique Sluijsmans

    2009-01-01

    Formal diplomas and certificates have been accepted as proof that students may receive exemption for parts of their educational programme. Nowadays, though, it is socially desirable that informal and non-formal learning experiences are also recognised. Assessment of prior learning (APL) addresses

  16. Investigation of Mathematics Teacher Candidates' Conceptual Structures about "Measurement" through Word Association Test: The Example of Turkey

    Science.gov (United States)

    Erdogan, Ahmet

    2017-01-01

    The purpose of this research is to determine mathematics teacher candidates' conceptual structures about the concept of "measurement" that is the one of the important learning fields of mathematics. Qualitative research method was used in this study. Participants of this study were 58 mathematics teacher candidates studying in one of the…

  17. Investigation of Physics Teacher Candidates' Cognitive Structures about "Electric Field": A Free Word Association Test Study

    Science.gov (United States)

    Türkkan, Ercan

    2017-01-01

    The aim of this study is to investigate the cognitive structures of physics teacher candidates about "electric field." Phenomenographic research method, one of the qualitative research patterns, was used in the study. The data of the study was collected from 91 physics teacher candidates who had taken General Physics II course at…

  18. An Assessment of Technical and Production Risks of Candidate Low-Cost Attitude/Heading Reference Systems(AHRS)

    Science.gov (United States)

    Yuchnovicz, Daniel; Burgess, Malcolm; Hammers, William

    1999-01-01

    This report provides an assessment of technical and production risks of candidate low-cost attitude/heading reference systems (AHRS) for use in the Advanced General Aviation Transport Experiments (AGATE) airplanes. A low-cost AHRS is a key component of modem "glass cockpit" flight displays for General Aviation (GA) aircraft. The technical capabilities of several candidate low-cost AHRS were examined and described along with the technical issues involved with using all solid-state components for attitude measurement. An economic model was developed which describes the expected profit, rate of return, and volume requirements for the manufacture of low-cost AHRS for GA aircraft in the 2000 to 2020 time frame. The model is the result of interviews with GA airframe manufacturers, avionics manufacturers and historical analysis of avionics of similar complexity. The model shows that a manufacturer will break even after three years of AHRS production, realizing an 18 percent rate of return (23 percent profit) on an investment of $3.5M over the 20 year period. A start-up production estimate showed costs of $6-12M for a new company to build and certify an AHRS from scratch, considered to be a high-risk proposition, versus $0.25-0.75M for an experienced avionics manufacturer to manufacture a design under license, a low-risk proposition.

  19. Report on Reactor Physics Assessment of Candidate Accident Tolerant Fuel Cladding Materials in LWRs

    Energy Technology Data Exchange (ETDEWEB)

    Powers, Jeffrey J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); George, Nathan [Univ. of Tennessee, Knoxville, TN (United States); Maldonado, G. Ivan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Worrall, Andrew [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-08-28

    This work focuses on ATF concepts being researched at Oak Ridge National Laboratory (ORNL), expanding on previous studies of using alternate cladding materials in pressurized water reactors (PWRs). The neutronic performance of two leading alternate cladding materials were assessed in boiling water reactors (BWRs): iron-chromium-aluminum (FeCrAl) cladding, and silicon carbide (SiC)-based composite cladding. This report fulfills ORNL Milestone M3FT-15OR0202332 within the fiscal year 2015 (FY15)

  20. Drug-induced hypotension SEP test and acetazolamide test using sup 133 Xe SPECT in patients with occlusive carotid disease; Selection of candidates for extracranial-intracranial bypass

    Energy Technology Data Exchange (ETDEWEB)

    Kuroda, Satoshi; Kamiyama, Hiroyasu; Abe, Hiroshi; Takigawa, Shugo [Hokkaido Univ., Sapporo (Japan). School of Medicine; Mitsumori, Kenji; Nomura, Mikio; Saitoh, Hisatoshi

    1991-01-01

    The correlation between the drug-induced hypotension somatosensory evoked potential (SEP) test and regional cerebral blood flow changes after acetazolamide administration was studied. Fourteen patients presenting with transient ischemic attack, reversible ischemic neurological deficits, or minor completed stroke were evaluated. All patients had no or only localized low-density areas on computed tomographic scans, and unilateral occlusion or severe stenosis of the internal carotid or middle cerebral artery on cerebral angiograms. The Diamox asymmetry enhancement (DAE) was studied to detect reduced cerebral perfusion reserve in the affected hemispheres. The DAE was 7.9+-5.8% in seven patients positive in the SEP test, significantly higher than -1.5+-2.9% in patients negative in the SEP test. Postoperative SEP tests were negative in all five patients who underwent extracranial-intracranial (EC-IC) bypass surgery, suggesting that the EC-IC bypass improved the cerebral perfusion reserve in the affected hemispheres. The DAE decreased significantly in four of these patients. This study disclosed a significant correlation between the drug-induced hypotension SEP test and DAE. These parameters are considered important for evaluating patients with hemodynamic compromise and/or suitable candidates for EC-IC bypass. (author).

  1. Assessing oral candidal carriage with mixed salivary glucose levels as non-invasive diagnostic tool in type-2 diabetics of davangere, karnataka, India.

    Science.gov (United States)

    Naik, Rashmi; Mujib B R, Ahmed; Raaju, U R; Telagi, Neethu

    2014-07-01

    The health of oral tissues is known to be related to salivary flow and its composition which may be altered in diabetic patients. The purpose of this study is to correlate mixed salivary glucose levels and oral candidal carriage and to assess the prevalence of candidal carriage in diabetics and controls. Thirty adults with type-2 diabetes and 30 without diabetes (control subjects), aged 30-60 yr, participated in the study. Unstimulated saliva was collected and investigated for glucose levels (using glucose oxidase method) and colony-forming units (CFU) of Candida, this was stained with two stains, periodic acid-schiff stain and Grocott Gomori stain. In the present study mixed salivary glucose concentration in diabetics was significantly higher (pCandida was not isolated. The diabetics without intraoral candidal carriage had lower salivary glucose levels (mean = 5.36±2.24 mg/dl). This relationship could be seen in controls (non-diabetics) also. Diabetics showed an oral candidal carriage rate of 80% which was significantly higher compared to nondiabetics who showed an oral candidal carriage rate of 40%. Mixed salivary glucose levels were significantly higher in diabetics. The possible high salivary glucose level could predispose to oral candidal infection. So saliva can be used as a quick, non-invasive tool to assess the oral candidal status and possible infection.

  2. Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

    Directory of Open Access Journals (Sweden)

    Fatou K. Ndiaye

    2017-06-01

    Full Text Available Objectives: Genome-wide association studies (GWAS have identified >100 loci independently contributing to type 2 diabetes (T2D risk. However, translational implications for precision medicine and for the development of novel treatments have been disappointing, due to poor knowledge of how these loci impact T2D pathophysiology. Here, we aimed to measure the expression of genes located nearby T2D associated signals and to assess their effect on insulin secretion from pancreatic beta cells. Methods: The expression of 104 candidate T2D susceptibility genes was measured in a human multi-tissue panel, through PCR-free expression assay. The effects of the knockdown of beta-cell enriched genes were next investigated on insulin secretion from the human EndoC-βH1 beta-cell line. Finally, we performed RNA-sequencing (RNA-seq so as to assess the pathways affected by the knockdown of the new genes impacting insulin secretion from EndoC-βH1, and we analyzed the expression of the new genes in mouse models with altered pancreatic beta-cell function. Results: We found that the candidate T2D susceptibility genes' expression is significantly enriched in pancreatic beta cells obtained by laser capture microdissection or sorted by flow cytometry and in EndoC-βH1 cells, but not in insulin sensitive tissues. Furthermore, the knockdown of seven T2D-susceptibility genes (CDKN2A, GCK, HNF4A, KCNK16, SLC30A8, TBC1D4, and TCF19 with already known expression and/or function in beta cells changed insulin secretion, supporting our functional approach. We showed first evidence for a role in insulin secretion of four candidate T2D-susceptibility genes (PRC1, SRR, ZFAND3, and ZFAND6 with no previous knowledge of presence and function in beta cells. RNA-seq in EndoC-βH1 cells with decreased expression of PRC1, SRR, ZFAND6, or ZFAND3 identified specific gene networks related to T2D pathophysiology. Finally, a positive correlation between the expression of Ins2 and the

  3. Test Bench Development for Femur Stability Assessment

    Directory of Open Access Journals (Sweden)

    Samuel SANCHEZ-CABALLERO

    2015-01-01

    Full Text Available This paper shows the design and development of a test bench for humanfemurs. The main uses of this test bench will run from artificial femurs comparisonwith real femurs, to join stability assessment after bone a fracture repair. Amongthis uses is specially designed for condylar fractures testing. The test bench isdeveloped from a self-made existing tensile/compression testing machine. Thedesign procedure is supported by a literature review about the bone mechanicalbehavior and composition generally and the knee joint performance and repairparticularly. On the basis of this review, the machine was designed to simulate theadduction and abduction movements of the joint. The magnitudes to be measuredare: the compression force, the bone displacement (vertical and the knee jointrotation

  4. Polysaccharide Fabrication Platforms and Biocompatibility Assessment as Candidate Wound Dressing Materials

    Directory of Open Access Journals (Sweden)

    Donald C. Aduba

    2017-01-01

    Full Text Available Wound dressings are critical for wound care because they provide a physical barrier between the injury site and outside environment, preventing further damage or infection. Wound dressings also manage and even encourage the wound healing process for proper recovery. Polysaccharide biopolymers are slowly becoming popular as modern wound dressings materials because they are naturally derived, highly abundant, inexpensive, absorbent, non-toxic and non-immunogenic. Polysaccharide biopolymers have also been processed into biomimetic platforms that offer a bioactive component in wound dressings that aid the healing process. This review primarily focuses on the fabrication and biocompatibility assessment of polysaccharide materials. Specifically, fabrication platforms such as electrospun fibers and hydrogels, their fabrication considerations and popular polysaccharides such as chitosan, alginate, and hyaluronic acid among emerging options such as arabinoxylan are discussed. A survey of biocompatibility and bioactive molecule release studies, leveraging polysaccharide’s naturally derived properties, is highlighted in the text, while challenges and future directions for wound dressing development using emerging fabrication techniques such as 3D bioprinting are outlined in the conclusion. This paper aims to encourage further investigation and open up new, disruptive avenues for polysaccharides in wound dressing material development.

  5. Diastolic Pressure Difference to Classify Pulmonary Hypertension in the Assessment of Heart Transplant Candidates.

    Science.gov (United States)

    Wright, Stephen P; Moayedi, Yasbanoo; Foroutan, Farid; Agarwal, Suhail; Paradero, Geraldine; Alba, Ana C; Baumwol, Jay; Mak, Susanna

    2017-09-01

    The diastolic pressure difference (DPD) is recommended to differentiate between isolated postcapillary and combined pre-/postcapillary pulmonary hypertension (Cpc-PH) in left heart disease (PH-LHD). However, in usual practice, negative DPD values are commonly calculated, potentially related to the use of mean pulmonary artery wedge pressure (PAWP). We used the ECG to gate late-diastolic PAWP measurements. We examined the method's impact on calculated DPD, PH-LHD subclassification, hemodynamic profiles, and mortality. We studied patients with advanced heart failure undergoing right heart catheterization to assess cardiac transplantation candidacy (N=141). Pressure tracings were analyzed offline over 8 to 10 beat intervals. Diastolic pulmonary artery pressure and mean PAWP were measured to calculate the DPD as per usual practice (diastolic pulmonary artery pressure-mean PAWP). Within the same intervals, PAWP was measured gated to the ECG QRS complex to calculate the QRS-gated DPD (diastolic pulmonary artery pressure-QRS-gated PAWP). Outcomes occurring within 1 year were collected retrospectively from chart review. Overall, 72 of 141 cases demonstrated PH-LHD. Within PH-LHD, the QRS-gated DPD yielded higher calculated DPD values (3 [-1 to 6] versus 0 [-4 to 3] mm Hg; P pulmonary hypertension ( P pulmonary hypertension. The QRS-gated DPD reclassifies a subset of PH-LHD patients from isolated postcapillary pulmonary hypertension to Cpc-PH, which is characterized by an adverse hemodynamic profile. © 2017 American Heart Association, Inc.

  6. Examination of Nonchromate Conversion Coatings for Aluminum Armor From Three Final Candidates Using Accelerated Corrosion and Adhesion Test Methods

    National Research Council Canada - National Science Library

    Placzankis, Brian

    2001-01-01

    This study examines the effectiveness of three final candidate nonchromate conversion coatings on aluminum alloys 5083, 7039, and 6061 coated with standard solvent-based Chemical Agent Resistant Coating (CARC) system...

  7. Unified Protocol for psychiatric and psychological assessment of candidates for transplantation of organs and tissues, PSI-CAT.

    Science.gov (United States)

    Fidel Kinori, Sara Guila; Alcántara Tadeo, Antonio; Castan Campanera, Esther; Costa Requena, Gemma; Diez Quevedo, Crisanto; Lligoña Garreta, Anna; Lopez Lazcano, Ana; Martínez del Pozo, Montserrat; Rangil Muñoz, Teresa; Peri Nogués, Josep María

    2015-01-01

    Transplantation is the treatment option that offers improved survival and quality of life as compared to organ failure. Psychiatric and psychological aspects of transplant candidates are important, especially in the pre-assessment stage, as the influence of these factors can hinder post-surgical outcome in both the implanted organ survival and the quality of life of the transplanted person. Of particular importance, are the factors related to pathology due to substance use, psychopathology, and psychosocial support. There are currently few guidelines on the correct evaluation of patients eligible for these complex procedures. Nineteen psychiatrists and clinical psychologists from six public hospitals in Catalonia conducted a systematic consensus to determine the design of a Unified Protocol psychological and psychiatric evaluation. An annual work plan was implemented, during which; the objectives were defined, a literature review was conducted, the inclusion and exclusion criteria were discussed, questionnaires were selected, and a structured interview was developed. With the implementation of the work plan, the Assessment Protocol presented in this article was designed. systematic work and improving cooperation between psychiatrists and clinical psychologists, has led to homogeneity and consensus on a unified evaluation protocol. Copyright © 2013 SEP y SEPB. Published by Elsevier España. All rights reserved.

  8. Advanced Test Reactor outage risk assessment

    International Nuclear Information System (INIS)

    Thatcher, T.A.; Atkinson, S.A.

    1997-01-01

    Beginning in 1997, risk assessment was performed for each Advanced Test Reactor (ATR) outage aiding the coordination of plant configuration and work activities (maintenance, construction projects, etc.) to minimize the risk of reactor fuel damage and to improve defense-in-depth. The risk assessment activities move beyond simply meeting Technical Safety Requirements to increase the awareness of risk sensitive configurations, to focus increased attention on the higher risk activities, and to seek cost-effective design or operational changes that reduce risk. A detailed probabilistic risk assessment (PRA) had been performed to assess the risk of fuel damage during shutdown operations including heavy load handling. This resulted in several design changes to improve safety; however, evaluation of individual outages had not been performed previously and many risk insights were not being utilized in outage planning. The shutdown PRA provided the necessary framework for assessing relative and absolute risk levels and assessing defense-in-depth. Guidelines were written identifying combinations of equipment outages to avoid. Screening criteria were developed for the selection of work activities to receive review. Tabulation of inherent and work-related initiating events and their relative risk level versus plant mode has aided identification of the risk level the scheduled work involves. Preoutage reviews are conducted and post-outage risk assessment is documented to summarize the positive and negative aspects of the outage with regard to risk. The risk for the outage is compared to the risk level that would result from optimal scheduling of the work to be performed and to baseline or average past performance

  9. 40 CFR Table C-4 to Subpart C of... - Test Specifications for PM10, PM2.5 and PM10-2.5 Candidate Equivalent Methods

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Test Specifications for PM10, PM2.5 and PM10-2.5 Candidate Equivalent Methods C Table C-4 to Subpart C of Part 53 Protection of Environment... Pt. 53, Subpt. C, Table C-4 Table C-4 to Subpart C of Part 53—Test Specifications for PM10, PM2.5 and...

  10. Current distribution, habitat, and status of Category 2 candidate plant species on and near the U.S. Department of Energy's Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Blomquist, Kevin W. [EG& G Energy Measurements, Gaithersburg, MD (United States); Lindemann, Tim A. [EG& G Energy Measurements, Gaithersburg, MD (United States); Lyon, Glen E. [EG& G Energy Measurements, Gaithersburg, MD (United States); Steen, Dan C. [EG& G Energy Measurements, Gaithersburg, MD (United States); Wills, Cathy A. [EG& G Energy Measurements, Gaithersburg, MD (United States); Flick, Sarah A. [EG& G Energy Measurements, Gaithersburg, MD (United States); Ostler, W. Kent [EG& G Energy Measurements, Gaithersburg, MD (United States)

    1995-12-31

    Results of surveys conducted between 1991 and 1995 were used to document the distribution and habitat of 11 Category 2 candidate plant species known to occur on or near the Nevada Test Site (NTS). Approximately 200 areas encompassing about 13,000 ha were surveyed. Distributions of all species except Frasera-pahutensis and Phaceliaparishii were increased, and the ranges of Camissonia megalantha, Galium hilendiae ssp. kingstonense, Penstemon albomarginatus, and Penstemon pahutensis were expanded. The status of each species was assessed based on current distribution population trends, and potential threats. Recommendations were made to reclassi& the following five species to Category 3C: Arctomecon merriamii, F. pahutensis, P. pahutensis, Phacelia beatleyae, and Phaceliaparishii. Two species, C. megalantha and Cymopterus ripIeyi var. saniculoides, were recommended for reclassification to Category 3B status. No recommendation was made to reclassify Astragalus funereus, G. hilendiae ssp. kingstonense, P. albomarginatus, or Penstemon fruticiformis var. amargosae from their current Category 2 status. Populations of these four species are not threatened on NTS, but the NTS populations represent only a.small portion of each species’ range and the potential threats of mining or grazing activities off NTS on these species was notassessed. Conservation measures recommended included the development of an NTS ecosystem conservation plan, continued conduct of preactivity and plant surveys on NTS, and protection of plant type localities on NTS.

  11. Kauai Test Facility hazards assessment document

    Energy Technology Data Exchange (ETDEWEB)

    Swihart, A

    1995-05-01

    The Department of Energy Order 55003A requires facility-specific hazards assessment be prepared, maintained, and used for emergency planning purposes. This hazards assessment document describes the chemical and radiological hazards associated with the Kauai Test Facility, Barking Sands, Kauai, Hawaii. The Kauai Test Facility`s chemical and radiological inventories were screened according to potential airborne impact to onsite and offsite individuals. The air dispersion model, ALOHA, estimated pollutant concentrations downwind from the source of a release, taking into consideration the toxicological and physical characteristics of the release site, the atmospheric conditions, and the circumstances of the release. The greatest distance to the Early Severe Health Effects threshold is 4.2 kilometers. The highest emergency classification is a General Emergency at the {open_quotes}Main Complex{close_quotes} and a Site Area Emergency at the Kokole Point Launch Site. The Emergency Planning Zone for the {open_quotes}Main Complex{close_quotes} is 5 kilometers. The Emergency Planning Zone for the Kokole Point Launch Site is the Pacific Missile Range Facility`s site boundary.

  12. Kauai Test Facility hazards assessment document

    International Nuclear Information System (INIS)

    Swihart, A.

    1995-05-01

    The Department of Energy Order 55003A requires facility-specific hazards assessment be prepared, maintained, and used for emergency planning purposes. This hazards assessment document describes the chemical and radiological hazards associated with the Kauai Test Facility, Barking Sands, Kauai, Hawaii. The Kauai Test Facility's chemical and radiological inventories were screened according to potential airborne impact to onsite and offsite individuals. The air dispersion model, ALOHA, estimated pollutant concentrations downwind from the source of a release, taking into consideration the toxicological and physical characteristics of the release site, the atmospheric conditions, and the circumstances of the release. The greatest distance to the Early Severe Health Effects threshold is 4.2 kilometers. The highest emergency classification is a General Emergency at the open-quotes Main Complexclose quotes and a Site Area Emergency at the Kokole Point Launch Site. The Emergency Planning Zone for the open-quotes Main Complexclose quotes is 5 kilometers. The Emergency Planning Zone for the Kokole Point Launch Site is the Pacific Missile Range Facility's site boundary

  13. Environmental assessment report: Nuclear Test Technology Complex

    International Nuclear Information System (INIS)

    Tonnessen, K.; Tewes, H.A.

    1982-08-01

    The US Department of Energy (USDOE) is planning to construct and operate a structure, designated the Nuclear Test Technology Complex (NTTC), on a site located west of and adjacent to the Lawrence Livermore National Laboratory. The NTTC is designed to house 350 nuclear test program personnel, and will accommodate the needs of the entire staff of the continuing Nuclear Test Program (NTP). The project has three phases: land acquisition, facility construction and facility operation. The purpose of this environmental assessment report is to describe the activities associated with the three phases of the NTTC project and to evaluate potential environmental disruptions. The project site is located in a rural area of southeastern Alameda County, California, where the primary land use is agriculture; however, the County has zoned the area for industrial development. The environmental impacts of the project include surface disturbance, high noise levels, possible increases in site erosion, and decreased air quality. These impacts will occur primarily during the construction phase of the NTTC project and can be mitigated in part by measures proposed in this report

  14. Click-PEGylation - A mobility shift approach to assess the redox state of cysteines in candidate proteins.

    Science.gov (United States)

    van Leeuwen, Lucie A G; Hinchy, Elizabeth C; Murphy, Michael P; Robb, Ellen L; Cochemé, Helena M

    2017-07-01

    The redox state of cysteine thiols is critical for protein function. Whereas cysteines play an important role in the maintenance of protein structure through the formation of internal disulfides, their nucleophilic thiol groups can become oxidatively modified in response to diverse redox challenges and thereby function in signalling and antioxidant defences. These oxidative modifications occur in response to a range of agents and stimuli, and can lead to the existence of multiple redox states for a given protein. To assess the role(s) of a protein in redox signalling and antioxidant defence, it is thus vital to be able to assess which of the multiple thiol redox states are present and to investigate how these alter under different conditions. While this can be done by a range of mass spectrometric-based methods, these are time-consuming, costly, and best suited to study abundant proteins or to perform an unbiased proteomic screen. One approach that can facilitate a targeted assessment of candidate proteins, as well as proteins that are low in abundance or proteomically challenging, is by electrophoretic mobility shift assays. Redox-modified cysteine residues are selectively tagged with a large group, such as a polyethylene glycol (PEG) polymer, and then the proteins are separated by electrophoresis followed by immunoblotting, which allows the inference of redox changes based on band shifts. However, the applicability of this method has been impaired by the difficulty of cleanly modifying protein thiols by large PEG reagents. To establish a more robust method for redox-selective PEGylation, we have utilised a Click chemistry approach, where free thiol groups are first labelled with a reagent modified to contain an alkyne moiety, which is subsequently Click-reacted with a PEG molecule containing a complementary azide function. This strategy can be adapted to study reversibly reduced or oxidised cysteines. Separation of the thiol labelling step from the PEG

  15. Psychometric Personality Differences Between Candidates in Astronaut Selection.

    Science.gov (United States)

    Mittelstädt, Justin M; Pecena, Yvonne; Oubaid, Viktor; Maschke, Peter

    This paper investigates personality traits as potential factors for success in an astronaut selection by comparing personality profiles of unsuccessful and successful astronaut candidates in different phases of the ESA selection procedure. It is further addressed whether personality traits could predict an overall assessment rating at the end of the selection. In 2008/2009, ESA performed an astronaut selection with 902 candidates who were either psychologically recommended for mission training (N = 46) or failed in basic aptitude (N = 710) or Assessment Center and interview testing (N = 146). Candidates completed the Temperament Structure Scales (TSS) and the NEO Personality Inventory Revised (NEO-PI-R). Those candidates who failed in basic aptitude testing showed higher levels of Neuroticism (M = 49.8) than the candidates who passed that phase (M = 45.4 and M = 41.6). Additionally, candidates who failed in basic testing had lower levels of Agreeableness (M = 132.9) than recommended candidates (M = 138.1). TSS scales for Achievement (r = 0.19) and Vitality (r = 0.18) showed a significant correlation with the overall assessment rating given by a panel board after a final interview. Results indicate that a personality profile similar to Helmreich's "Right Stuff" is beneficial in astronaut selection. Influences of test anxiety on performance are discussed. Mittelstädt JM, Pecena Y, Oubaid V, Maschke P. Psychometric personality differences between candidates in astronaut selection. Aerosp Med Hum Perform. 2016; 87(11):933-939.

  16. Candidate genes in panic disorder

    DEFF Research Database (Denmark)

    Howe, A. S.; Buttenschön, Henriette N; Bani-Fatemi, A.

    2016-01-01

    The utilization of molecular genetics approaches in examination of panic disorder (PD) has implicated several variants as potential susceptibility factors for panicogenesis. However, the identification of robust PD susceptibility genes has been complicated by phenotypic diversity, underpowered...... association studies and ancestry-specific effects. In the present study, we performed a succinct review of case-control association studies published prior to April 2015. Meta-analyses were performed for candidate gene variants examined in at least three studies using the Cochrane Mantel-Haenszel fixed......-effect model. Secondary analyses were also performed to assess the influences of sex, agoraphobia co-morbidity and ancestry-specific effects on panicogenesis. Meta-analyses were performed on 23 variants in 20 PD candidate genes. Significant associations after correction for multiple testing were observed...

  17. The Use of Semantic Differential to Assess the Perceptions and Attitudes of Preservice and Advanced Degree Candidates Toward Various Exceptionalities.

    Science.gov (United States)

    Stodden, Robert A.; Ianacone, Robert N.

    The perceptions of three groups (n=30) of bachelor level special education majors and doctoral candidates in education toward the mentally retarded and various other exceptionalities were measured after exposure to three types of treatment. Of the three groups, the control group received no treatment, experimental group I received negative…

  18. Preliminary assessment of nuclear waste transportation cost and risk for operation of the first repository at candidate sites

    International Nuclear Information System (INIS)

    Peterson, R.W.; McSweeney, T.I.; Varadarajan, R.V.; Wilmot, E.L.; Cashwell, J.W.; Joy, D.S.

    1983-01-01

    To support the selection of the first commercial nuclear waste repository site in 1987, environmental analyses of five candidate site locations are currently being performed. The five locations are in the Gulf Interior Region, the Permian Basin, the Paradox Basin, Yucca Mountain and the Hanford reservation. Costs and operational risks associated with the transportation of nuclear wastes to a single repository located in these regions have been calculated for a life-cycle of 26 years

  19. On the assessment of usability testing methods for children

    NARCIS (Netherlands)

    Markopoulos, P.; Bekker, M.M.

    2003-01-01

    The paper motivates the need to acquire methodological knowledge for involving children as test users in usability testing. It introduces a methodological framework for delineating comparative assessments of usability testing methods for children participants. This framework consists in three

  20. Evaluation of the biomarker candidate MFAP4 for non-invasive assessment of hepatic fibrosis in hepatitis C patients

    DEFF Research Database (Denmark)

    Bracht, Thilo; Mölleken, Christian; Ahrens, Maike

    2016-01-01

    in a retrospective study including n = 542 hepatitis C patients. We applied a univariate logistic regression model based on MFAP4 serum levels and furthermore derived a multivariate model including also age and gender. Youden-optimal cutoffs for binary classification were determined for both models without......). CONCLUSIONS: We confirmed the applicability of MFAP4 as a novel serum biomarker for assessment of hepatic fibrosis and identification of high-risk patients with severe fibrosis stages in hepatitis C. The combination of MFAP4 with existing tests might lead to a more accurate non-invasive diagnosis of hepatic...... fibrosis and allow a cost-effective disease management in the era of new direct acting antivirals....

  1. Assessing Primary Literacy through Grammar Tests

    Science.gov (United States)

    Hodgson, John

    2017-01-01

    Originally an editorial for "English in Education," this short article summarises key issues in the imposition of a separate test for grammar, punctuation and spelling. It illustrates the poor foundations, lack of clarity and distortion of curriculum which invalidate the test.

  2. Theoretical Models, Assessment Frameworks and Test Construction.

    Science.gov (United States)

    Chalhoub-Deville, Micheline

    1997-01-01

    Reviews the usefulness of proficiency models influencing second language testing. Findings indicate that several factors contribute to the lack of congruence between models and test construction and make a case for distinguishing between theoretical models. Underscores the significance of an empirical, contextualized and structured approach to the…

  3. Mobile Romberg test assessment (mRomberg).

    Science.gov (United States)

    Galán-Mercant, Alejandro; Cuesta-Vargas, Antonio I

    2014-09-12

    The diagnosis of frailty is based on physical impairments and clinicians have indicated that early detection is one of the most effective methods for reducing the severity of physical frailty. Maybe, an alternative to the classical diagnosis could be the instrumentalization of classical functional testing, as Romberg test or Timed Get Up and Go Test. The aim of this study was (I) to measure and describe the magnitude of accelerometry values in the Romberg test in two groups of frail and non-frail elderly people through instrumentation with the iPhone 4®, (II) to analyse the performances and differences between the study groups, and (III) to analyse the performances and differences within study groups to characterise accelerometer responses to increasingly difficult challenges to balance. This is a cross-sectional study of 18 subjects over 70 years old, 9 frail subjects and 9 non-frail subjects. The non-parametric Mann-Whitney U test was used for between-group comparisons in means values derived from different tasks. The Wilcoxon Signed-Rank test was used to analyse differences between different variants of the test in both independent study groups. The highest difference between groups was found in the accelerometer values with eyes closed and feet parallel: maximum peak acceleration in the lateral axis (p test between frail and non-frail elderly people. In addition, the results indicate that the accelerometry values also were significantly different between the frail and non-frail groups, and that values from the accelerometer accelerometer increased as the test was made more complicated.

  4. Test method to assess interface adhesion in composite bonding

    NARCIS (Netherlands)

    Teixeira de Freitas, S.; Sinke, J.

    2015-01-01

    This paper introduces a new type of peel tests dedicated to composite bonding: Composite Peel Tests. This test is inspired on the standard floating roller peel test widely used for metal bonding. The aim of this study is to investigate the potential of the Composite Peel Test to assess interface

  5. Personality Test Scores that Distinguish U.S. Air Force Remotely Piloted Aircraft Drone Pilot Training Candidates

    Science.gov (United States)

    2014-02-18

    advancement of aviation drone technology has led to significant developments and improvements in the capabilities of military remotely piloted aircraft...stress; less excitement seeking and action oriented; less assertive; more socially introverted and withdrawn; more socially compliant and...to age and educational differences. Fifth, evaluations that involve selection and assessment of pilot applicants should include collateral sources of

  6. Adapting the Critical Thinking Assessment Test for Palestinian Universities

    Science.gov (United States)

    Basha, Sami; Drane, Denise; Light, Gregory

    2016-01-01

    Critical thinking is a key learning outcome for Palestinian students. However, there are no validated critical thinking tests in Arabic. Suitability of the US developed Critical Thinking Assessment Test (CAT) for use in Palestine was assessed. The test was piloted with university students in English (n = 30) and 4 questions were piloted in Arabic…

  7. Trial application of the candidate root cause categorization scheme and preliminary assessment of selected data bases for the root causes of component failures program

    International Nuclear Information System (INIS)

    Bruske, S.Z.; Cadwallader, L.C.; Stepina, P.L.

    1985-04-01

    The objective of the Nuclear Regulatory Commission's (NRC) Root Causes of Component Failures Program is to develop and apply a categorization scheme for identifying root causes of failures for components that comprise safety and safety support systems of nuclear power plants. Results from this program will provide valuable input in the areas of probabilistic risk assessment, reliability assurance, and application of risk assessments in the inspection program. This report presents the trial application and assessment of the candidate root cause categorization scheme to three failure data bases: the In-Plant Reliability Data System (IPRDS), the Licensee Event Report (LER) data base, and the Nuclear Plant Reliability Data System (NPRDS). Results of the trial application/assessment show that significant root cause information can be obtained from these failure data bases

  8. SPACE Code Assessment for FLECHT Test

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Hyoung Kyoun; Min, Ji Hong; Park, Chan Eok; Park, Seok Jeong; Kim, Shin Whan [KEPCO E and C, Daejeon (Korea, Republic of)

    2015-10-15

    According to 10 CFR 50 Appendix K, Emergency Core Cooling System (ECCS) performance evaluation model during LBLOCA should be based on the data of FLECHT test. Heat transfer coefficient (HTC) and Carryout Rate Fraction (CRF) during reflood period of LBLOCA should be conservative. To develop Mass and Energy Release (MER) methodology using Safety and Performance Analysis CodE (SPACE), FLECHT test results were compared to the results calculated by SPACE. FLECHT test facility is modeled to compare the reflood HTC and CRF using SPACE. Sensitivity analysis is performed with various options for HTC correlation. Based on this result, it is concluded that the reflood HTC and CRF calculated with COBRA-TF correlation during LBLOCA meet the requirement of 10 CFR 50 Appendix K. In this study, the analysis results using SPACE predicts heat transfer phenomena of FLECHT test reasonably and conservatively. Reflood HTC for the test number of 0690, 3541 and 4225 are conservative in the reference case. In case of 6948 HTC using COBRATF is conservative to calculate film boiling region. All of analysis results for CRF have sufficient conservatism. Based on these results, it is possible to apply with COBRA-TF correlation to develop MER methodology to analyze LBLOCA using SPACE.

  9. Fast flux test facility hazards assessment

    International Nuclear Information System (INIS)

    Sutton, L.N.

    1994-01-01

    This document establishes the technical basis in support of Emergency Planning Activities for the Fast Flux Test Facility on the Hanford Site. The document represents an acceptable interpretation of the implementing guidance document for DOE Order 5500.3A. Through this document, the technical basis for the development of facility specific Emergency Action Levels and the Emergency Planning Zone is demonstrated

  10. Candidal colonization, strain diversity, and antifungal susceptibility among adult diabetic patients.

    Science.gov (United States)

    Al-Attas, Safia A; Amro, Soliman O

    2010-01-01

    Candidal colonization in diabetics is a matter of debate. The aim of this study is to investigate oral candidal colonization, strain diversity, antifungal susceptibility, and the influence of local and systemic host factors on candidal colonization in adult diabetics. We conducted a case-control study that compared 150 diabetics (49 type 1, 101 type 2) with 50 healthy controls. Two salivary samples were collected, using the oral rinse sampling method: one for salivary flow rate and pH determination, and the other for candidal colonization assessment. The candidal isolates were identified and tested in vitro for antifungal susceptibility using the commercial kit, Candifast. The relationship between specific host factors and candidal colonization was also investigated. Diabetics had a higher candidal carriage rate compared to controls, but not density. Candida albicans was the most frequently isolated species, but diabetics had a variety of other candidal species present. None of the control samples were resistant to any tested antifungal, while the diabetic samples had differing resistances to azole antifungals. Although there was a significant positive correlation between glycemic control and candidal colonization in type 2 diabetics, there was a negative correlation between salivary pH and candidal carriage in the controls versus density in type 2 diabetics. Diabetic patients not only had a higher candidal carriage rate, but also a variety of candidal species that were resistant to azole antifungals. Oral candidal colonization was significantly associated with glycemic control, type of diabetes, and salivary pH.

  11. Testing of Candidate Polymeric Materials for Compatibility with Pure Alternate Pretreat as Part of the Universal Waste Management System (UWMS)

    Science.gov (United States)

    Wingard, C. D.

    2018-01-01

    The Universal Waste Management System (UWMS) is an improved Waste Collection System for astronauts living and working in low Earth orbit spacecraft. Polymeric materials used in water recovery on International Space Station are regularly exposed to phosphoric acid-treated 'pretreated' urine. Polymeric materials used in UWMS are not only exposed to pretreated urine, but also to concentrated phosphoric acid with oxidizer before dilution known as 'pure pretreat.' Samples of five different polymeric materials immersed in pure pretreat for 1 year were tested for liquid compatibility by measuring changes in storage modulus with a dynamic mechanical analyzer.

  12. Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet.

    Science.gov (United States)

    Thevis, Mario; Geyer, Hans; Thomas, Andreas; Schänzer, Wilhelm

    2011-05-01

    Identifying the use of non-approved drugs by cheating athletes has been a great challenge for doping control laboratories. This is due to the additional complexities associated with identifying relatively unknown and uncharacterized compounds and their metabolites as opposed to known and well-studied therapeutics. In 2010, the prohibited drug candidates and gene doping substances AICAR and GW1516, together with the selective androgen receptor modulator (SARM) MK-2866 were obtained by the Cologne Doping Control Laboratory from Internet suppliers and their structure, quantity, and formulation elucidated. All three compounds proved authentic as determined by liquid chromatography-high resolution/high accuracy (tandem) mass spectrometry and comparison to reference material. While AICAR was provided as a colourless powder in 100 mg aliquots, GW1516 was obtained as an orange/yellow suspension in water/glycerol (150 mg/ml), and MK-2866 (25 mg/ml) was shipped dissolved in polyethylene glycol (PEG) 300. In all cases, the quantified amounts were considerably lower than indicated on the label. The substances were delivered via courier, with packaging identifying them as containing 'amino acids' and 'green tea extract', arguably to circumvent customs control. Although all of the substances were declared 'for research only', their potential misuse in illicit performance-enhancement cannot be excluded; moreover sports drug testing authorities should be aware of the facile availability of black market copies of these drug candidates. Copyright © 2011 John Wiley & Sons, Ltd.

  13. Safety assessment for the rf Test Facility

    International Nuclear Information System (INIS)

    Nagy, A.; Beane, F.

    1984-08-01

    The Radio Frequency Test Facility (RFTF) is a part of the Magnetic Fusion Program's rf Heating Experiments. The goal of the Magnetic Fusion Program (MFP) is to develop and demonstrate the practical application of fusion. RFTF is an experimental device which will provide an essential link in the research effort aiming at the realization of fusion power. This report was compiled as a summary of the analysis done to ensure the safe operation of RFTF

  14. Operational Based Vision Assessment Automated Vision Test Collection User Guide

    Science.gov (United States)

    2017-05-15

    AFRL-SA-WP-SR-2017-0012 Operational Based Vision Assessment Automated Vision Test Collection User Guide Elizabeth Shoda, Alex...June 2015 – May 2017 4. TITLE AND SUBTITLE Operational Based Vision Assessment Automated Vision Test Collection User Guide 5a. CONTRACT NUMBER... automated vision tests , or AVT. Development of the AVT was required to support threshold-level vision testing capability needed to investigate the

  15. Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28

    Science.gov (United States)

    Poirier, Nicolas; Mary, Caroline; Le Bas-Bernardet, Stephanie; Daguin, Veronique; Belarif, Lyssia; Chevalier, Melanie; Hervouet, Jeremy; Minault, David; Ville, Simon; Charpy, Vianney; Blancho, Gilles; Vanhove, Bernard

    2014-01-01

    Antagonist anti-CD28 antibodies prevent T-cell costimulation and are functionally different from CTLA4Ig since they cannot block CTLA-4 and PDL-1 co-inhibitory signals. They demonstrated preclinical efficacy in suppressing effector T cells while enhancing immunoregulatory mechanisms. Because a severe cytokine release syndrome was observed during the Phase 1 study with the superagonist anti-CD28 TGN1412, development of other anti-CD28 antibodies requires careful preclinical evaluation to exclude any potential immunotoxicity side-effects. The failure to identify immunological toxicity of TGN1412 using macaques led us to investigate more relevant preclinical models. We report here that contrary to macaques, and like in man, all baboon CD4-positive T lymphocytes express CD28 in their effector memory cells compartment, a lymphocyte subtype that is the most prone to releasing cytokines after reactivation. Baboon lymphocytes are able to release pro-inflammatory cytokines in vitro in response to agonist or superagonist anti-CD28 antibodies. Furthermore, we compared the reactivity of human and baboon lymphocytes after transfer into non obese diabetic/severe combined immunodeficiency (NOD/SCID) interleukin-2rγ knockout mice and confirmed that both cell types could release inflammatory cytokines in situ after injection of agonistic anti-CD28 antibodies. In contrast, FR104, a monovalent antagonistic anti-CD28 antibody, did not elicit T cell activation in these assays, even in the presence of anti-drug antibodies. Infusion to baboons also resulted in an absence of cytokine release. In conclusion, the baboon represents a suitable species for preclinical immunotoxicity evaluation of anti-CD28 antibodies because their effector memory T cells do express CD28 and because cytokine release can be assessed in vitro and trans vivo. PMID:24598534

  16. Comparative Testing for Corporate Impact Assessment Tools

    DEFF Research Database (Denmark)

    Farsang, Andrea; Reisch, Lucia A.

    of our study are: poverty, water and sanitation, education, food and agriculture, climate change, and human rights in three industries, namely: footwear, coffee, and paper and pulp. The paper develops a protocol for the selection and quantification of indicators that can be used in selecting...... the appropriate tools for measuring impacts in the selected sectors on SDGs. Background: In the Global Value Project, a long list of indicators was compiled covering the main thematic areas and challenges of sustainability. In a second step, this long list was reduced using predefined criteria as well as other...... criteria, such as the feasibility and scalability of different tools. As a result, a protocol was developed to help compare the different tools that measure corporate impact and to interpret the results in relation to the SDGs. The protocol was pre-tested with a limited number of tools in two case studies...

  17. Design, fabrication, and operation of capsules for the irradiation testing of candidate advanced space reactor fuel pins

    International Nuclear Information System (INIS)

    Thoms, K.R.

    1975-04-01

    Fuel irradiation experiments were designed, built, and operated to test uranium mononitride (UN) fuel clad in tungsten-lined T-111 (Ta-8 percent W-2 percent Hf) and uranium dioxide (UO 2 ) fuel clad in both tungsten-lined T-111 and tungsten-lined Nb-1 percent Zr. A total of nine fuel pins was irradiated (four containing porous UN, two containing dense, nonporous UN, and three containing dense UO 2 ) at average cladding temperatures ranging from 931 to 1015 0 C. The UN experiments, capsules UN-4 and -5, operated for 10,480 and 10,037 hr, respectively, at an average linear heat generation rate of 10 kW/ft. The UO 2 experiment, capsule UN-6, operated for 8333 hr at an average linear heat generation rate of approximately 5 kW/ft. Following irradiation, the nine fuel pins were removed from their capsules, externally examined, and sent to the NASA Plum Brook Facility for more detailed postirradiation examination. During visual examination, it was discovered that the cladding of the fuel pin containing dense UN in each of capsules UN-4 and -5 had failed, exposing the UN fuel to the NaK in which the pins were submerged and permitting the release of fission gas from the failed pins. A rough analysis of the fission gas seen in samples of the gas in the fuel pin region indicated fission gas release-to-birth rates from these fuel pins in the range of 10 -5 . (U.S.)

  18. A Feasibility Assessment of Behavioral-based Interviewing to Improve Candidate Selection for a Pulmonary and Critical Care Medicine Fellowship Program.

    Science.gov (United States)

    Tatem, Geneva; Kokas, Maria; Smith, Cathy L; DiGiovine, Bruno

    2017-04-01

    Traditional interviews for residency and fellowship training programs are an important component in the selection process, but can be of variable value due to a nonstandardized approach. We redesigned the candidate interview process for our large pulmonary and critical care medicine fellowship program in the United States using a behavioral-based interview (BBI) structure. The primary goal of this approach was to standardize the assessment of candidates within noncognitive domains with the goal of selecting those with the best fit for our institution's fellowship program. Eight faculty members attended two BBI workshops. The first workshop identified our program's "best fit" criteria using the framework of the Accreditation Council for Graduate Medical Education's six core competencies and additional behaviors that fit within our programs. BBI questions were then selected from a national database and refined based on the attributes deemed most important by our faculty. In the second workshop, faculty practiced the BBI format in mock interviews with third-year fellows. The interview process was further refined based on feedback from the interviewees, and then applied with fellowship candidates for the 2014 recruitment season. The 1-year pilot of behavioral-based interviewing allowed us to achieve consensus on the traits sought for our incoming fellows and to standardize the interview process for our program using the framework of the Accreditation Council for Graduate Medical Education core competencies. Although the effects of this change on the clinical performance of our fellows have not yet been assessed, this description of our development and implementation processes may be helpful for programs seeking to redesign their applicant interviews.

  19. Objective assessment of surgical performance and its impact on a national selection programme of candidates for higher surgical training in plastic surgery.

    LENUS (Irish Health Repository)

    Carroll, Sean M

    2012-02-01

    OBJECTIVE: The objective of this study was to develop and validate a transparent, fair and objective assessment programme for the selection of surgical trainees into higher surgical training (HST) in plastic surgery in the Republic of Ireland. METHODS: Thirty-four individuals applied for HST in plastic surgery at the Royal College of Surgeons in Ireland (RCSI) in the academic years 2005-2006 and 2006-2007. Eighteen were short-listed for interview and further assessment. All applicants were required to report on their undergraduate educational performance and their postgraduate professional development. Short-listed applicants completed validated objective assessment simulations of surgical skills, an interview and assessment of their suitability for a career in surgery. RESULTS: When applicants\\' short-listing scores were combined with their interview scores and assessment of their suitability for a career in surgery, individuals who were selected for HST in plastic surgery performed significantly better than those who were not (P<0.002). However, when the assessment of technical skills scores were added the significance level of this difference increased further (P<0.0001) as did the statistical power of the difference to 99.9%, thus increasing the robustness of the selection package. CONCLUSION: The results from this study suggest that the assessment protocol we used to select individuals for HST in plastic surgery reliably and statistically significantly discriminated between the performances of candidates.

  20. Assessing Social Isolation: Pilot Testing Different Methods.

    Science.gov (United States)

    Taylor, Harry Owen; Herbers, Stephanie; Talisman, Samuel; Morrow-Howell, Nancy

    2016-04-01

    Social isolation is a significant public health problem among many older adults; however, most of the empirical knowledge about isolation derives from community-based samples. There has been less attention given to isolation in senior housing communities. The objectives of this pilot study were to test two methods to identify socially isolated residents in low-income senior housing and compare findings about the extent of isolation from these two methods. The first method, self-report by residents, included 47 out of 135 residents who completed in-person interviews. To determine self-report isolation, residents completed the Lubben Social Network Scale 6 (LSNS-6). The second method involved a staff member who reported the extent of isolation on all 135 residents via an online survey. Results indicated that 26% of residents who were interviewed were deemed socially isolated by the LSNS-6. Staff members rated 12% of residents as having some or a lot of isolation. In comparing the two methods, staff members rated 2% of interviewed residents as having a lot of isolation. The combination of self-report and staff report could be more informative than just self-report alone, particularly when participation rates are low. However, researchers should be aware of the potential discrepancy between these two methods.

  1. Assessment of subsidence in karst terranes at selected areas in East Tennessee and comparison with a candidate site at Oak Ridge, Tennessee: Phase 2

    International Nuclear Information System (INIS)

    Newton, J.G.; Tanner, J.M.

    1987-09-01

    Work in the respective areas included assessment of conditions related to sinkhole development. Information collected and assessed involved geology, hydrogeology, land use, lineaments and linear trends, identification of karst features and zones, and inventory of historical sinkhole development and type. Karstification of the candidate, Rhea County, and Morristown study areas, in comparison to other karst areas in Tennessee, can be classified informally as youthful, submature, and mature, respectively. Historical sinkhole development in the more karstified areas is attributed to the greater degree of structural deformation by faulting and fracturing, subsequent solutioning of bedrock, thinness of residuum, and degree of development by man. Sinkhole triggering mechanisms identified are progressive solution of bedrock, water-level fluctuations, piping, and loading. 68 refs., 18 figs., 11 tabs

  2. Wald Sequential Probability Ratio Test for Space Object Conjunction Assessment

    Science.gov (United States)

    Carpenter, James R.; Markley, F Landis

    2014-01-01

    This paper shows how satellite owner/operators may use sequential estimates of collision probability, along with a prior assessment of the base risk of collision, in a compound hypothesis ratio test to inform decisions concerning collision risk mitigation maneuvers. The compound hypothesis test reduces to a simple probability ratio test, which appears to be a novel result. The test satisfies tolerances related to targeted false alarm and missed detection rates. This result is independent of the method one uses to compute the probability density that one integrates to compute collision probability. A well-established test case from the literature shows that this test yields acceptable results within the constraints of a typical operational conjunction assessment decision timeline. Another example illustrates the use of the test in a practical conjunction assessment scenario based on operations of the International Space Station.

  3. Counseling and Testing: What Counselors Need to Know about State Laws on Assessment and Testing

    Science.gov (United States)

    Naugle, Kim A.

    2009-01-01

    This article discusses testing in counseling, the history of psychology's attempts to restrict access to testing, and the potential impact on the public. Counselors are encouraged to obtain appropriate training in assessment and to understand that testing is not only consistent with fair testing policies but also essential for ethical practice.…

  4. Glyceria maxima as new test species for the EU risk assessment for herbicides: a microcosm study.

    Science.gov (United States)

    Mohr, S; Schott, J; Hoenemann, L; Feibicke, M

    2015-03-01

    In its recent guidance document on tiered risk assessment for plant protection products for aquatic organisms, the European Food Safety Authority (EFSA) proposed to use Glyceria maxima as monocotyledonous grass species for the testing of special herbicide groups. However, published toxicity data for this species is very limited and there is no test guideline for Glyceria sp. For this reason a microcosm study was conducted in order to gain experience on the degree of sensitivity of G. maxima to the herbicidal substances clodinafop-propargyl (grass herbicide) and fluroxypyr (auxin) in comparison to the already established test organism water milfoil Myriophyllum spicatum and the duckweed species Landoltia punctata. Five concentrations without replicates were tested for each test substance using 10 microcosms and three microcosms served as controls. The experiment was run for 8 weeks. Morphological endpoints were used to determine growth and EC50 values. The results show that M. spicatum was most sensitive to fluroxypyr (37 days EC50 for roots: 62 µg/L) and G. maxima most sensitive to clodinafop-propargyl (22 days EC50 for total shoot length: 48 µg/L) whereas the duckweed species was considerable less sensitive. Hence, G. maxima turns out to be a good candidate for testing grass specific herbicides, supporting its inclusion as an additional macrophyte test for the risk assessment of herbicides as proposed by the EFSA.

  5. Assessors' use of personality traits in descriptions of assessment centre candidates : A five-factor model perspective

    NARCIS (Netherlands)

    Lievens, F.; de Fruyt, F.; van Dam, K.

    2001-01-01

    In assessment centres assessors are typically taught to note down behavioural observations. However, previous studies have shown that about 20% of assessor notes contain trait descriptors. Instead of regarding these descriptors as errors, this study examines their position in a personality

  6. Teleaudiology: efficacy assessment of an online social network as a support tool for parents of children candidates for cochlear implant.

    Science.gov (United States)

    Aiello, Camila Piccini; Ferrari, Deborah Viviane

    2015-01-01

    To assess the efficacy of an online social network as a support for parents of children with hearing impairment. Twenty-two mothers, randomly divided into experimental (n=11) and control (n=11) groups, filled in an online form containing the Parental Stress Index - Short Form (PSI-SF). Only the experimental group had access to the "Babies' Portal" social network. Both groups filled in the online form once again 3 months after the first assessment, for evaluating the use and participation in the social network. The posts on the social network were rated by two independent raters regarding themes and mechanisms of self-help. No difference was observed in mean PSI-SF scores between the groups for both assessments. Intragroup analysis showed no difference for total and subscale results of PSI-SF between the two data collected for both groups except for the "Defensive Response" subscale, in which a decrease was observed in the score for the control group. The most frequent posting themes were related to personal information and expressions of religious beliefs. Regarding self-help mechanisms, a higher frequency of exchanging experiences and gratitude expressions was observed. Participants in the experimental group stated they would have liked to participate more frequently in the social network as they considered this tool important because of the exchange of information and experience with other mothers and hearing health-care professionals. The posts and the assessment of participants indicated the potential of this network to support parents of children with hearing impairment.

  7. Identification of candidate children for maturity-onset diabetes of the young type 2 (MODY2 gene testing: a seven-item clinical flowchart (7-iF.

    Directory of Open Access Journals (Sweden)

    Michele Pinelli

    Full Text Available MODY2 is the most prevalent monogenic form of diabetes in Italy with an estimated prevalence of about 0.5-1.5%. MODY2 is potentially indistinguishable from other forms of diabetes, however, its identification impacts on patients' quality of life and healthcare resources. Unfortunately, DNA direct sequencing as diagnostic test is not readily accessible and expensive. In addition current guidelines, aiming to establish when the test should be performed, proved a poor detection rate. Aim of this study is to propose a reliable and easy-to-use tool to identify candidate patients for MODY2 genetic testing. We designed and validated a diagnostic flowchart in the attempt to improve the detection rate and to increase the number of properly requested tests. The flowchart, called 7-iF, consists of 7 binary "yes or no" questions and its unequivocal output is an indication for whether testing or not. We tested the 7-iF to estimate its clinical utility in comparison to the clinical suspicion alone. The 7-iF, in a prospective 2-year study (921 diabetic children showed a precision of about the 76%. Using retrospective data, the 7-iF showed a precision in identifying MODY2 patients of about 80% compared to the 40% of the clinical suspicion. On the other hand, despite a relatively high number of missing MODY2 patients, the 7-iF would not suggest the test for 90% of the non-MODY2 patients, demonstrating that a wide application of this method might 1 help less experienced clinicians in suspecting MODY2 patients and 2 reducing the number of unnecessary tests. With the 7-iF, a clinician can feel confident of identifying a potential case of MODY2 and suggest the molecular test without fear of wasting time and money. A Qaly-type analysis estimated an increase in the patients' quality of life and savings for the health care system of about 9 million euros per year.

  8. Earthworm avoidance test for soil assessments. An alternative for acute and reproduction tests

    Energy Technology Data Exchange (ETDEWEB)

    Hund-Rinke, K.; Wiechering, H. [Fraunhofer-Inst. fuer Umweltchemie und Oekotoxikologie, Schmallenberg (Germany)

    2001-07-01

    For ecotoxicological assessments of contaminated or remediated soils pointing to the habitat function of soils for biocenoses, standardized tests with earthworms (acute test, reproduction test) are available among others. Tests used for routine applications should be sensitive and indicate impacts on test organisms after short test periods. The usually applied earthworm tests do not satisfactorily fulfil these criteria. Therefore, in the present work, a behavioural test with earthworms (test criterion: avoidance) was investigated in detail using uncontaminated, artificially contaminated and originally contaminated soils. It was demonstrated that the avoidance behaviour is primarily determined by pollutants, and not by chemical-physical soil properties. The sensitivity of the presented test reaches the sensitivity of established tests. For waste sites, a considerably higher sensitivity was determined. An avoidance behaviour of at least 80% of the worms leaving the soil to be assessed is proposed as a criterion for toxicity. (orig.)

  9. Potential Errors and Test Assessment in Software Product Line Engineering

    Directory of Open Access Journals (Sweden)

    Hartmut Lackner

    2015-04-01

    Full Text Available Software product lines (SPL are a method for the development of variant-rich software systems. Compared to non-variable systems, testing SPLs is extensive due to an increasingly amount of possible products. Different approaches exist for testing SPLs, but there is less research for assessing the quality of these tests by means of error detection capability. Such test assessment is based on error injection into correct version of the system under test. However to our knowledge, potential errors in SPL engineering have never been systematically identified before. This article presents an overview over existing paradigms for specifying software product lines and the errors that can occur during the respective specification processes. For assessment of test quality, we leverage mutation testing techniques to SPL engineering and implement the identified errors as mutation operators. This allows us to run existing tests against defective products for the purpose of test assessment. From the results, we draw conclusions about the error-proneness of the surveyed SPL design paradigms and how quality of SPL tests can be improved.

  10. Double Trait Assessment Test Battery for Air Force Pilots

    National Research Council Canada - National Science Library

    Tarnowski, Adam

    1998-01-01

    Building on years of theoretical discussions as well as diagnostic experience in the Polish Air Force Institute of Aviation Medicine, a battery of psychological tests was proposed for the assessment...

  11. Testing the nature of the supermassive black hole candidate in SgrA* with light curves and images of hot spots

    International Nuclear Information System (INIS)

    Li, Zilong; Kong, Lingyao; Bambi, Cosimo

    2014-01-01

    General relativity makes clear predictions about the spacetime geometry around black holes. In the near future, new facilities will have the capability to explore the metric around SgrA*, the supermassive black hole candidate at the center of our Galaxy, and to open a new window to test the Kerr black hole hypothesis. In this paper, we compute light curves and images associated with compact emission regions (hot spots) orbiting around Kerr and non-Kerr black holes. We study how the analysis of the properties of the radiation emitted by a hot spot can be used to test the Kerr nature of SgrA*. We find that the sole observation of the hot spot light curve can at most constrain a combination of the black hole spin and of possible deviations from the Kerr solution. This happens because the same orbital frequency around a Kerr black hole can be found for a non-Kerr object with a different spin parameter. Second order corrections in the light curve due to the background geometry are typically too small to be identified. While the observation of the hot spot centroid track can potentially bound possible deviations from the Kerr solution, that is out of reach for the near future for the Very Large Telescope Interferometer instrument GRAVITY. The Kerr black hole hypothesis could really be tested in the case of the discovery of a radio pulsar in a compact orbit around SgrA*. Radio observations of such a pulsar would provide precise estimates of the mass and the spin of SgrA*, and the combination of these measurements (probing the weak field) with the hot spot light curve information (probing the strong field) may constrain/find possible deviations from the Kerr solution with quite good precision.

  12. Testing the nature of the supermassive black hole candidate in SgrA* with light curves and images of hot spots

    Energy Technology Data Exchange (ETDEWEB)

    Li, Zilong; Kong, Lingyao; Bambi, Cosimo [Center for Field Theory and Particle Physics and Department of Physics, Fudan University, 200433 Shanghai (China)

    2014-06-01

    General relativity makes clear predictions about the spacetime geometry around black holes. In the near future, new facilities will have the capability to explore the metric around SgrA*, the supermassive black hole candidate at the center of our Galaxy, and to open a new window to test the Kerr black hole hypothesis. In this paper, we compute light curves and images associated with compact emission regions (hot spots) orbiting around Kerr and non-Kerr black holes. We study how the analysis of the properties of the radiation emitted by a hot spot can be used to test the Kerr nature of SgrA*. We find that the sole observation of the hot spot light curve can at most constrain a combination of the black hole spin and of possible deviations from the Kerr solution. This happens because the same orbital frequency around a Kerr black hole can be found for a non-Kerr object with a different spin parameter. Second order corrections in the light curve due to the background geometry are typically too small to be identified. While the observation of the hot spot centroid track can potentially bound possible deviations from the Kerr solution, that is out of reach for the near future for the Very Large Telescope Interferometer instrument GRAVITY. The Kerr black hole hypothesis could really be tested in the case of the discovery of a radio pulsar in a compact orbit around SgrA*. Radio observations of such a pulsar would provide precise estimates of the mass and the spin of SgrA*, and the combination of these measurements (probing the weak field) with the hot spot light curve information (probing the strong field) may constrain/find possible deviations from the Kerr solution with quite good precision.

  13. Dark matter candidates

    International Nuclear Information System (INIS)

    Turner, M.S.

    1989-01-01

    One of the simplest, yet most profound, questions we can ask about the Universe is, how much stuff is in it, and further what is that stuff composed of? Needless to say, the answer to this question has very important implications for the evolution of the Universe, determining both the ultimate fate and the course of structure formation. Remarkably, at this late date in the history of the Universe we still do not have a definitive answer to this simplest of questions---although we have some very intriguing clues. It is known with certainty that most of the material in the Universe is dark, and we have the strong suspicion that the dominant component of material in the Cosmos is not baryons, but rather is exotic relic elementary particles left over from the earliest, very hot epoch of the Universe. If true, the Dark Matter question is a most fundamental one facing both particle physics and cosmology. The leading particle dark matter candidates are: the axion, the neutralino, and a light neutrino species. All three candidates are accessible to experimental tests, and experiments are now in progress. In addition, there are several dark horse, long shot, candidates, including the superheavy magnetic monopole and soliton stars. 13 refs

  14. Testing Trends: Considerations for Choosing and Using Assessments

    Science.gov (United States)

    Woods, Julie Rowland

    2015-01-01

    While federal law requires students to be tested in math, English-language arts and science in particular grades, states are still struggling to mount the resources and expertise necessary to fully implement college and career readiness standards, let alone new assessments aligned to these higher standards. New assessments are not only more…

  15. Utility of proverb interpretation measures with cardiac transplant candidates.

    Science.gov (United States)

    Dugbartey, A T

    1998-12-01

    To assess metaphorical understanding and proverb interpretation in cardiac transplant candidates, the neuropsychological assessment records of 22 adults with end-stage cardiac disease under consideration for transplantation were analyzed. Neuropsychological tests consisted of the Controlled Oral Word Association Test, Halstead Category Test, Rey-Osterrieth Complex Figure Test (Copy), Trial Making Test, and summed scores for the proverb items of the WAIS-R Comprehension subtest. Analysis showed that the group tended to interpret proverbs literally. Proverb scores were significantly associated with scores on the Similarities and Picture Arrangement subtests of the WAIS-R. There was a moderate negative association between number of reported heart attacks and Proverb scores. The need for brief yet robust assessments including measures of inferential thinking and conceptualization in transplant candidates are highlighted.

  16. A Serious Flaw in the Collegiate Learning Assessment [CLA] Test

    Directory of Open Access Journals (Sweden)

    Kevin Possin

    2013-09-01

    Full Text Available The Collegiate Learning Assessment Test (CLA has become popular and highly recommended, praised for its reliability and validity. I argue that while the CLA may be a commendable test for measuring critical-thinking, problem-solving, and logical-reasoning skills, those who are scoring students’ answers to the test’s questions are rendering the CLA invalid.

  17. Assessing difference between classical test theory and item ...

    African Journals Online (AJOL)

    Assessing difference between classical test theory and item response theory methods in scoring primary four multiple choice objective test items. ... All research participants were ranked on the CTT number correct scores and the corresponding IRT item pattern scores from their performance on the PRISMADAT. Wilcoxon ...

  18. Preliminary Options Assessment of Versatile Irradiation Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Sen, Ramazan Sonat [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    The objective of this report is to summarize the work undertaken at INL from April 2016 to January 2017 and aimed at analyzing some options for designing and building a versatile test reactor; the scope of work was agreed upon with DOE-NE. Section 2 presents some results related to KNK II and PRISM Mod A. Section 3 presents some alternatives to the VCTR presented in [ ] as well as a neutronic parametric study to assess the minimum power requirement needed for a 235U metal fueled fast test reactor capable to generate a fast (>100 keV) flux of 4.0 x 1015 n /cm2-s at the test location. Section 4 presents some results regarding a fundamental characteristic of test reactors, namely displacement per atom (dpa) in test samples. Section 5 presents the INL assessment of the ANL fast test reactor design FASTER. Section 6 presents a summary.

  19. Caveats for using statistical significance tests in research assessments

    DEFF Research Database (Denmark)

    Schneider, Jesper Wiborg

    2013-01-01

    controversial and numerous criticisms have been leveled against their use. Based on examples from articles by proponents of the use statistical significance tests in research assessments, we address some of the numerous problems with such tests. The issues specifically discussed are the ritual practice......This article raises concerns about the advantages of using statistical significance tests in research assessments as has recently been suggested in the debate about proper normalization procedures for citation indicators by Opthof and Leydesdorff (2010). Statistical significance tests are highly...... argue that applying statistical significance tests and mechanically adhering to their results are highly problematic and detrimental to critical thinking. We claim that the use of such tests do not provide any advantages in relation to deciding whether differences between citation indicators...

  20. FY11 Facility Assessment Study for Aeronautics Test Program

    Science.gov (United States)

    Loboda, John A.; Sydnor, George H.

    2013-01-01

    This paper presents the approach and results for the Aeronautics Test Program (ATP) FY11 Facility Assessment Project. ATP commissioned assessments in FY07 and FY11 to aid in the understanding of the current condition and reliability of its facilities and their ability to meet current and future (five year horizon) test requirements. The principle output of the assessment was a database of facility unique, prioritized investments projects with budgetary cost estimates. This database was also used to identify trends for the condition of facility systems.

  1. A new adaptive testing algorithm for shortening health literacy assessments

    Directory of Open Access Journals (Sweden)

    Currie Leanne M

    2011-08-01

    Full Text Available Abstract Background Low health literacy has a detrimental effect on health outcomes, as well as ability to use online health resources. Good health literacy assessment tools must be brief to be adopted in practice; test development from the perspective of item-response theory requires pretesting on large participant populations. Our objective was to develop a novel classification method for developing brief assessment instruments that does not require pretesting on large numbers of research participants, and that would be suitable for computerized adaptive testing. Methods We present a new algorithm that uses principles of measurement decision theory (MDT and Shannon's information theory. As a demonstration, we applied it to a secondary analysis of data sets from two assessment tests: a study that measured patients' familiarity with health terms (52 participants, 60 items and a study that assessed health numeracy (165 participants, 8 items. Results In the familiarity data set, the method correctly classified 88.5% of the subjects, and the average length of test was reduced by about 50%. In the numeracy data set, for a two-class classification scheme, 96.9% of the subjects were correctly classified with a more modest reduction in test length of 35.7%; a three-class scheme correctly classified 93.8% with a 17.7% reduction in test length. Conclusions MDT-based approaches are a promising alternative to approaches based on item-response theory, and are well-suited for computerized adaptive testing in the health domain.

  2. Computerized Tests. New practical and ethical challenges for Psychological Assessment

    Directory of Open Access Journals (Sweden)

    Gabriela Susana Lozzia

    2013-08-01

    Full Text Available The purpose of this study is to bring the readers in our field of knowledge closer to the new problems and solutions resulting from the application of computer systems to Psychological Assessment. Therefore, this work puts forward a suitable implementation of Computer-based and Internet-delivered Testing, includes a description of the new technologies that can be applied to Psychological Assessment: administration of traditional paper-and-pencil tests through computers, elaboration of automated reports, computerized adaptive tests, automated test construction and automatic generation of items, as well as the specific guidelines and regulations governing the development of each of these areas. This study provides an outline of the current issues connected with the appropriate use of Computerized Tests by way of conclusion and finally encourages psychologists to keep debating and reflecting on these topics.

  3. Assessment of salt tolerance of some newly developed and candidate wheat (triticum aestivum l.) cultivars using gas exchange and chlorophyll fluorescence attributes

    International Nuclear Information System (INIS)

    Kanwal, H.; Shahbaz, M.; Ashraf, M.

    2011-01-01

    The present study was aimed to assess salt tolerance of some newly developed and candidate cultivars of wheat using gas exchange and chlorophyll fluorescence parameters. Ten wheat cultivars including five newly developed (S-24, Saher-2006, Fsd-2008, Lasani and Inqlab-91) and five candidate (P .B-18, M.P-65, S.H-20, AARI-10 and G.A-20) were grown in sand culture. Salt stress (150 mM NaCl in Hoagland's nutrient solution) was applied at the seedling stage. A significant reduction in plant biomass production was recorded in all wheat cultivars. Cultivars S-24, Saher-2006 and Fsd-2008 showed less reduction in biomass production as compared with the other cultivars. Different gas exchange attributes such as leaf net photosynthetic rate (A), transpiration rate ( E), and stomatal conductance (gs) were also adversely affected due to salt stress and were positively associated with the plant biomass production of the genotypes under saline stress. More negative effects in relation to these gas exchange attributes were recorded in cvs. Lasani, G.A-20 and ARRI-10 than those in the other cultivars. Leaf maximum chlorophyll fluorescence (Fm), maximum fluorescence at steady state (Fms ), and photochemical fluorescence quenching (Qp) increased while maximum quantum yield (Fv/Fm), quantum yield of electron transport (Qp), electron transport rate ( ETR ) and non-photochemical quenching (Qn) decreased due to imposition of salt stress. The adverse effects of salt stress on these chlorophyll fluorescence attributes were minimum in cultivars S-24, Saher-2006 and Fsd-2008. A significant positive correlation was recorded between biomass production, different gas exchange attributes and chlorophyll fluorescence parameters. Overall, cvs. S-24, Saher-2006 and Fsd-2008 were ranked as salt tolerant on the basis of their performance in biomass production, gas exchange attributes and chlorophyll fluorescence parameters. (author)

  4. Specificity and sensitivity assessment of selected nasal provocation testing techniques

    Directory of Open Access Journals (Sweden)

    Edyta Krzych-Fałta

    2016-12-01

    Full Text Available Introduction: Nasal provocation testing involves an allergen-specific local reaction of the nasal mucosa to the administered allergen. Aim: To determine the most objective nasal occlusion assessment technique that could be used in nasal provocation testing. Material and methods : A total of 60 subjects, including 30 patients diagnosed with allergy to common environmental allergens and 30 healthy subjects were enrolled into the study. The method used in the study was a nasal provocation test with an allergen, with a standard dose of a control solution and an allergen (5,000 SBU/ml administered using a calibrated atomizer into both nostrils at room temperature. Early-phase nasal mucosa response in the early phase of the allergic reaction was assessed via acoustic rhinometry, optical rhinometry, nitric oxide in nasal air, and tryptase levels in the nasal lavage fluid. Results : In estimating the homogeneity of the average values, the Levene’s test was used and receiver operating characteristic curves were plotted for all the methods used for assessing the nasal provocation test with an allergen. Statistically significant results were defined for p < 0.05. Of all the objective assessment techniques, the most sensitive and characteristic ones were the optical rhinometry techniques (specificity = 1, sensitivity = 1, AUC = 1, PPV = 1, NPV = 1. Conclusions : The techniques used showed significant differences between the group of patients with allergic rhinitis and the control group. Of all the objective assessment techniques, those most sensitive and characteristic were the optical rhinometry.

  5. Procedure to select test organisms for environmental risk assessment of genetically modified crops in aquatic systems.

    Science.gov (United States)

    Hilbeck, Angelika; Bundschuh, Rebecca; Bundschuh, Mirco; Hofmann, Frieder; Oehen, Bernadette; Otto, Mathias; Schulz, Ralf; Trtikova, Miluse

    2017-11-01

    For a long time, the environmental risk assessment (ERA) of genetically modified (GM) crops focused mainly on terrestrial ecosystems. This changed when it was scientifically established that aquatic ecosystems are exposed to GM crop residues that may negatively affect aquatic species. To assist the risk assessment process, we present a tool to identify ecologically relevant species usable in tiered testing prior to authorization or for biological monitoring in the field. The tool is derived from a selection procedure for terrestrial ecosystems with substantial but necessary changes to adequately consider the differences in the type of ecosystems. By using available information from the Water Framework Directive (2000/60/EC), the procedure can draw upon existing biological data on aquatic systems. The proposed procedure for aquatic ecosystems was tested for the first time during an expert workshop in 2013, using the cultivation of Bacillus thuringiensis (Bt) maize as the GM crop and 1 stream type as the receiving environment in the model system. During this workshop, species executing important ecological functions in aquatic environments were identified in a stepwise procedure according to predefined ecological criteria. By doing so, we demonstrated that the procedure is practicable with regard to its goal: From the initial long list of 141 potentially exposed aquatic species, 7 species and 1 genus were identified as the most suitable candidates for nontarget testing programs. Integr Environ Assess Manag 2017;13:974-979. © 2017 SETAC. © 2017 SETAC.

  6. Functional validation of candidate genes detected by genomic feature models

    DEFF Research Database (Denmark)

    Rohde, Palle Duun; Østergaard, Solveig; Kristensen, Torsten Nygaard

    2018-01-01

    Understanding the genetic underpinnings of complex traits requires knowledge of the genetic variants that contribute to phenotypic variability. Reliable statistical approaches are needed to obtain such knowledge. In genome-wide association studies, variants are tested for association with trait...... then functionally assessed whether the identified candidate genes affected locomotor activity by reducing gene expression using RNA interference. In five of the seven candidate genes tested, reduced gene expression altered the phenotype. The ranking of genes within the predictive GO term was highly correlated...

  7. Genome-Wide Scan and Test of Candidate Genes in the Snail Biomphalaria glabrata Reveal New Locus Influencing Resistance to Schistosoma mansoni.

    Directory of Open Access Journals (Sweden)

    Jacob A Tennessen

    Full Text Available New strategies to combat the global scourge of schistosomiasis may be revealed by increased understanding of the mechanisms by which the obligate snail host can resist the schistosome parasite. However, few molecular markers linked to resistance have been identified and characterized in snails.Here we test six independent genetic loci for their influence on resistance to Schistosoma mansoni strain PR1 in the 13-16-R1 strain of the snail Biomphalaria glabrata. We first identify a genomic region, RADres, showing the highest differentiation between susceptible and resistant inbred lines among 1611 informative restriction-site associated DNA (RAD markers, and show that it significantly influences resistance in an independent set of 439 outbred snails. The additive effect of each RADres resistance allele is 2-fold, similar to that of the previously identified resistance gene sod1. The data fit a model in which both loci contribute independently and additively to resistance, such that the odds of infection in homozygotes for the resistance alleles at both loci (13% infected is 16-fold lower than the odds of infection in snails without any resistance alleles (70% infected. Genome-wide linkage disequilibrium is high, with both sod1 and RADres residing on haplotype blocks >2 Mb, and with other markers in each block also showing significant effects on resistance; thus the causal genes within these blocks remain to be demonstrated. Other candidate loci had no effect on resistance, including the Guadeloupe Resistance Complex and three genes (aif, infPhox, and prx1 with immunological roles and expression patterns tied to resistance, which must therefore be trans-regulated.The loci RADres and sod1 both have strong effects on resistance to S. mansoni. Future approaches to control schistosomiasis may benefit from further efforts to characterize and harness this natural genetic variation.

  8. Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape

    International Nuclear Information System (INIS)

    Snellenberg, Suzanne; Strooper, Lise MA De; Hesselink, Albertus T; Meijer, Chris JLM; Snijders, Peter JF; Heideman, Daniëlle AM; Steenbergen, Renske DM

    2012-01-01

    Quantitative methylation-specific PCR (qMSP) analysis for determining the methylation status of (candidate) tumor suppressor genes has potential as objective and valuable test to triage high-risk human papillomavirus (hrHPV) positive women in cervical screening. Particularly combined methylation analysis of a panel of genes shows most promising clinical performance, with sensitivity levels that equal or exceed that of cytology. However, the wide application of such methylation marker panels is hampered by the lack of effective multiplex assays allowing simultaneous methylation detection of various targets in a single reaction. Here, we designed and analyzed a multiplex qMSP assay for three genes whose methylation was previously found to be informative for cervical (pre)cancer (i.e. CADM1, MAL and hsa-miR-124-2) as well as a reference gene β-actin. Based on our experience, we discuss the optimization of the parameters that provide a practical approach towards multiplex qMSP design. Primers and PCR reagents were optimized for multiplex qMSP purposes and the resulting assay was analytically validated on serial dilutions of methylated DNA in unmethylated DNA, and compared with singleplex counterparts on hrHPV-positive cervical scrapings. Upon optimization, including primer redesign and primer limiting assays, the multiplex qMSP showed the same analytical performance as the singleplex qMSPs. A strong correlation between the obtained normalized ratios of the singleplex and multiplex qMSPs on cervical scrapes was found for all three markers: CADM1 (R 2 =0.985), MAL (R 2 =0.986) and hsa-miR-124-2 (R 2 =0.944). Multiplex qMSP offers a promising approach for high-throughput diagnostic analysis of the methylation status of multiple genes, which after proper design and validation can be equally specific, sensitive and reproducible as its singleplex versions

  9. Affirmative Psychological Testing and Neurocognitive Assessment with Transgender Adults.

    Science.gov (United States)

    Keo-Meier, Colton L; Fitzgerald, Kara M

    2017-03-01

    Neither consensus on best practice nor validated neuropsychological, intelligence, or personality testing batteries exist for assessment and psychological testing on the transgender population. Historically, assessment has been used in a gate-keeping fashion with transgender clients. There are no firm standards of care when considering the content and appropriateness of evaluations conducted presurgically. These evaluations are discussed in the setting of other presurgical evaluations, with a recommendation to move toward a competency to make a medical decisions model. Additional considerations are discussed, such as effects of transition on mood and how to interpret scores in a field where normative data are often gender stratified. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Testing and assessment strategies, including alternative and new approaches

    DEFF Research Database (Denmark)

    Meyer, Otto A.

    2003-01-01

    The object of toxicological testing is to predict possible adverse effect in humans when exposed to chemicals whether used as industrial chemicals, pharmaceuticals or pesticides. Animal models are predominantly used in identifying potential hazards of chemicals. The use of laboratory animals raises...... ethical concern. However, irrespective of animal welfare it is an important aspect of the discipline of toxicology that the primary object is human health. The ideal testing and assessment strategy is simple to use all the available test methods and preferably more in laboratory animal species from which...... uses and of the absence of health problems involved with their use. Thus, the regulatory toxicology is a cocktail of science and pragmatism added a crucial concern for animal welfare. Test methods are most often used in a testing sequence as bricks in a testing strategy. The main key driving forces...

  11. [Diagnostic test scale SI5: Assessment of sacroiliac joint dysfunction].

    Science.gov (United States)

    Acevedo González, Juan C; Quintero Oliveros, Silvia

    2015-01-01

    Sacroiliac joint dysfunction is a known cause of low back pain. We think that a diagnostic score scale (SI5) may be performed to assess diagnostic utility of clinical signs of sacroiliac joint dysfunction. The primary aim of the present study was to conduct the pilot study of our new diagnostic score scale, the SI5, for sacroiliac joint syndrome. We reviewed the literature on clinical characteristics, diagnostic tests and imaging most commonly used in diagnosing sacroiliac joint dysfunction. Our group evaluated the diagnostic utility of these aspects and we used those considered most representative to develop the SI5 diagnostic scale. The SI5 scale was applied to 22 patients with low back pain; afterwards, the standard test for diagnosing this pathology (selective blockage of the SI joint) was also performed on these patients. The sensitivity and specificity for each sign were also assessed and the diagnostic scale called SI5 was then proposed, based on these data. The most sensitive clinical tests for diagnosing SI joint dysfunction were 2 patient-reported clinical characteristics, the Laguerre Test, sacroiliac rocking test and Yeomans test (greater than 80% sensitivity). The tests with greatest diagnostic specificity (>80%) were the Lewitt test, Piedallu test and Gillet test. The proposed SI5 test score scale showed sensitivity of 73% and specificity of 71%. Sacroiliac joint syndrome has been shown to produce low back pain frequently; however, the diagnostic value of examination tests for sacroiliac joint pain has been questioned by other authors. The pilot study on the SI5 diagnostic score scale showed good sensitivity and specificity. However, the process of statistical validation of the SI5 needs to be continued. Copyright © 2014 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  12. Testing and assessment of low alloy steel for marine application

    International Nuclear Information System (INIS)

    Amjad, M.; Ahmad, S.; Mahmood, K.; Qureshi, A.H.

    2007-01-01

    This paper is an account of the work carried out during the assessment of low alloy steel (WH-80) for marine application. The relevant acceptance criteria consulted during the process is DEFST AN 02-874 and a standard reference material. Assessment is based on the experimental results of the tests carried out for the steel. Testing comprised of mechanical (tensile, impact and hardness) tests, corrosion (immersion corrosion and stress corrosion cracking) tests, metallography test and weldability (weld joint strength, controlled thermal severity -CTS and Y -Groove) tests undertaken at various testing laboratories in Pakistan. The results obtained after testing have been compared with acceptance criteria (DEFSTAN 02-874 and standard reference material). Moreover results have been compared with contemporary steels used for marine applications. Results showed a reasonable agreement with results available in literature for other low alloy steels with respect to mechanical strength and weldability. Steel weldments qualified the weld joint strength tests and weldability tests. Toughness has been measured at various temperatures. Results revealed that the toughness of base metal is higher than heat affected zone (HAZ) and weld metal. In weldability tests, weld metal and HAZ were examined microscopically to investigate integrity of weld. No cracks have been observed in the weld which indicates complete diffusion in to the welding material. WH- 80 steel has exhibited comparatively high corrosion rate, reduction in tensile strength during SCC test and low Charpy energy values at -50 degree C. It is therefore concluded that the WH-80 steel is unsuitable for use in application at subzero (OC) temperatures and in highly corrosive environment. (author)

  13. Environmental Assessment for the LGF Spill Test Facility at Frenchman Flat, Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    Patton, S.E.; Novo, M.G.; Shinn, J.H.

    1986-04-01

    The LGF Spill Test Facility at Frenchman Flat, Nevada Test Site, is being constructed by the United States Department of Energy (DOE). In this Environmental Assessment, environmental consequences of spilling hazardous materials in the Frenchman Flat basin are evaluated and mitigations and recommendations are stated in order to protect natural resources and reduce land-use impacts. Guidelines and restrictions concerning spill-test procedures will be determined by the LGF Test Facility Operations Manager and DOE based on toxicity documentation for the test material, provided by the user, and mitigations imposed by the Environmental Assessment. In addition to Spill Test Facility operational procedures, certain assumptions have been made in preparation of this document: no materials will be considered for testing that have cumulative, long-term persistence in the environment; spill tests will consist of releases of 15 min or less; and sufficient time will be allowed between tests for recovery of natural resources. Geographic limits to downwind concentrations of spill materials were primarily determined from meteorological data, human occupational exposure standards to hazardous materials and previous spill tests. These limits were established using maximum spill scenarios and environmental impacts are discussed as worst case scenarios; however, spill-test series will begin with smaller spills, gradually increasing in size after the impacts of the initial tests have been evaluated.

  14. Environmental Assessment for the LGF Spill Test Facility at Frenchman Flat, Nevada Test Site

    International Nuclear Information System (INIS)

    Patton, S.E.; Novo, M.G.; Shinn, J.H.

    1986-04-01

    The LGF Spill Test Facility at Frenchman Flat, Nevada Test Site, is being constructed by the United States Department of Energy (DOE). In this Environmental Assessment, environmental consequences of spilling hazardous materials in the Frenchman Flat basin are evaluated and mitigations and recommendations are stated in order to protect natural resources and reduce land-use impacts. Guidelines and restrictions concerning spill-test procedures will be determined by the LGF Test Facility Operations Manager and DOE based on toxicity documentation for the test material, provided by the user, and mitigations imposed by the Environmental Assessment. In addition to Spill Test Facility operational procedures, certain assumptions have been made in preparation of this document: no materials will be considered for testing that have cumulative, long-term persistence in the environment; spill tests will consist of releases of 15 min or less; and sufficient time will be allowed between tests for recovery of natural resources. Geographic limits to downwind concentrations of spill materials were primarily determined from meteorological data, human occupational exposure standards to hazardous materials and previous spill tests. These limits were established using maximum spill scenarios and environmental impacts are discussed as worst case scenarios; however, spill-test series will begin with smaller spills, gradually increasing in size after the impacts of the initial tests have been evaluated

  15. [Normative values of kinetic tests in VNG assessment].

    Science.gov (United States)

    Zamysłowska-Szmytke, Ewa; Sliwińska-Kowalska, Mariola

    2011-01-01

    Balance assessment plays an important role in occupational medicine. The diagnosis of patients with balance disturbances is based on a number of laboratory tests, including rotational chair tests, one of the most important. The normative value of kinetic tests greatly depends on movement parameters and laboratory equipment, which vary between diagnostic centers. The aim of the presented paper was to establish normatives for our laboratory and testing methodology in a group of healthy persons. The balance examination included 45 healthy persons (21 women and 24 men) aged 20-63 years (mean 38.5 +/- 14.9). The study population underwent very thorough neuro-otological examination, static posturography and VNG tests. The caloric test result was a crucial criterion for inclusion to the group of healthy persons. Rotational tests included: one "burst" test analyzing vestibulo-ocular reflex (VOR) with and without optokinetic stimulation visual vestibular optokinetic reflex (VVOR) and cervico-ocular reflex (COR); three impulse tests and sinusoidal harmonic rotation tests of 0.04, 0.08, 0.1, 0.16, 0.32, and 0.64 Hz. The mean values were: VVOR, 0.9 +/- 0.1; VOR, 0.5 +/- 0.1; and COR, 0.2 +/- 0.1. The mean value of rotational and post-rotational nystagmus induced by sudden chair stop (impulse stimulus) was 9 +/- 7 s, the gain values were 0.4 for sinusoidal tests, in the stimulation range of 0.1-0.32 and 0.5 for 0.64 Hz stimulation. There was no significant linear relationship between age and test parameters except for the test using sinusoidal-decreasing stimulation. These normative values form the base for a closer incorporation of rotational tests in occupational medicine procedures.

  16. Expanding Horizons and Unresolved Conundrums: Language Testing and Assessment

    Science.gov (United States)

    Leung, Constant; Lewkowicz, Jo

    2006-01-01

    Since the last "TESOL Quarterly" commemorative issue 15 years ago, there have been too many important developments in language testing and assessment for all of them to be discussed in a single article. Therefore, this article focuses on issues that we believe are integrally linked to pedagogic and curriculum concerns of English language teaching.…

  17. Linking the Virginia SOL Assessments to NWEA MAP Tests

    Science.gov (United States)

    Northwest Evaluation Association, 2016

    2016-01-01

    Northwest Evaluation Association™ (NWEA™) is committed to providing partners with useful tools to help make inferences from the Measures of Academic Progress® (MAP®) interim assessment scores. Recently, NWEA completed a concordance study to connect the scales of the Virginia Standards of Learning (SOL) reading and math tests with those of the MAP…

  18. Pilot Test of an Innovative Interprofessional Education Assessment Strategy

    Science.gov (United States)

    Emmert, Michelle Christine

    2011-01-01

    The primary goal of this study was to test an innovative way of assessing students' teamwork skills in a controlled environment. Twenty-four second year students from Western University of Health Sciences (WesternU) participated in the experimental group and 22 third year students from WesternU participated in the control group. Students in the…

  19. Comparative assessment of seller's staining test (SST) and direct ...

    African Journals Online (AJOL)

    the only standard method. Objective: This study was designed to assess the sensitivity and specificity of the SST in relation to the 'gold standard' dFAT in diagnosis of rabies in Nigeria. Methods: A total of 88 animal specimens submitted to the Rabies National Reference Laboratory, Nigeria were routinely tested for rabies by ...

  20. Advanced Marketing Core Curriculum. Test Items and Assessment Techniques.

    Science.gov (United States)

    Smith, Clifton L.; And Others

    This document contains duties and tasks, multiple-choice test items, and other assessment techniques for Missouri's advanced marketing core curriculum. The core curriculum begins with a list of 13 suggested textbook resources. Next, nine duties with their associated tasks are given. Under each task appears one or more citations to appropriate…

  1. The Empirical Testing of a Musical Performance Assessment Paradigm

    Science.gov (United States)

    Russell, Brian E.

    2010-01-01

    The purpose of this study was to test a hypothesized model of aurally perceived performer-controlled musical factors that influence assessments of performance quality. Previous research studies on musical performance constructs, musical achievement, musical expression, and scale construction were examined to identify the factors that influence…

  2. Assessment of the Diagnostic Potential of Clinotech TB Screen Test ...

    African Journals Online (AJOL)

    The Clinotech TB Screen test, a 3rd generation multi-antigen rapid chromatographic immunoassay for detection of IgG antibodies in serum against recombinant protein antigens 38kDa, 16kDa and 6kDa, was assessed for its diagnostic potential for diagnosis of active pulmonary TB in routine TB control programme in Abia ...

  3. Citizen Candidates Under Uncertainty

    OpenAIRE

    Eguia, Jon X.

    2005-01-01

    In this paper we make two contributions to the growing literature on "citizen-candidate" models of representative democracy. First, we add uncertainty about the total vote count. We show that in a society with a large electorate, where the outcome of the election is uncertain and where winning candidates receive a large reward from holding office, there will be a two-candidate equilibrium and no equilibria with a single candidate. Second, we introduce a new concept of equilibrium, which we te...

  4. Validity of a new assessment rubric for a short-answer test of clinical reasoning.

    Science.gov (United States)

    Yeung, Euson; Kulasagarem, Kulamakan; Woods, Nicole; Dubrowski, Adam; Hodges, Brian; Carnahan, Heather

    2016-07-26

    The validity of high-stakes decisions derived from assessment results is of primary concern to candidates and certifying institutions in the health professions. In the field of orthopaedic manual physical therapy (OMPT), there is a dearth of documented validity evidence to support the certification process particularly for short-answer tests. To address this need, we examined the internal structure of the Case History Assessment Tool (CHAT); this is a new assessment rubric developed to appraise written responses to a short-answer test of clinical reasoning in post-graduate OMPT certification in Canada. Fourteen physical therapy students (novices) and 16 physical therapists (PT) with minimal and substantial OMPT training respectively completed a mock examination. Four pairs of examiners (n = 8) participated in appraising written responses using the CHAT. We conducted separate generalizability studies (G studies) for all participants and also by level of OMPT training. Internal consistency was calculated for test questions with more than 2 assessment items. Decision studies were also conducted to determine optimal application of the CHAT for OMPT certification. The overall reliability of CHAT scores was found to be moderate; however, reliability estimates for the novice group suggest that the scale was incapable of accommodating for scores of novices. Internal consistency estimates indicate item redundancies for several test questions which will require further investigation. Future validity studies should consider discriminating the clinical reasoning competence of OMPT trainees strictly at the post-graduate level. Although rater variance was low, the large variance attributed to error sources not incorporated in our G studies warrant further investigations into other threats to validity. Future examination of examiner stringency is also warranted.

  5. Independent test assessment using the extreme value distribution theory.

    Science.gov (United States)

    Almeida, Marcio; Blondell, Lucy; Peralta, Juan M; Kent, Jack W; Jun, Goo; Teslovich, Tanya M; Fuchsberger, Christian; Wood, Andrew R; Manning, Alisa K; Frayling, Timothy M; Cingolani, Pablo E; Sladek, Robert; Dyer, Thomas D; Abecasis, Goncalo; Duggirala, Ravindranath; Blangero, John

    2016-01-01

    The new generation of whole genome sequencing platforms offers great possibilities and challenges for dissecting the genetic basis of complex traits. With a very high number of sequence variants, a naïve multiple hypothesis threshold correction hinders the identification of reliable associations by the overreduction of statistical power. In this report, we examine 2 alternative approaches to improve the statistical power of a whole genome association study to detect reliable genetic associations. The approaches were tested using the Genetic Analysis Workshop 19 (GAW19) whole genome sequencing data. The first tested method estimates the real number of effective independent tests actually being performed in whole genome association project by the use of an extreme value distribution and a set of phenotype simulations. Given the familiar nature of the GAW19 data and the finite number of pedigree founders in the sample, the number of correlations between genotypes is greater than in a set of unrelated samples. Using our procedure, we estimate that the effective number represents only 15 % of the total number of independent tests performed. However, even using this corrected significance threshold, no genome-wide significant association could be detected for systolic and diastolic blood pressure traits. The second approach implements a biological relevance-driven hypothesis tested by exploiting prior computational predictions on the effect of nonsynonymous genetic variants detected in a whole genome sequencing association study. This guided testing approach was able to identify 2 promising single-nucleotide polymorphisms (SNPs), 1 for each trait, targeting biologically relevant genes that could help shed light on the genesis of the human hypertension. The first gene, PFH14 , associated with systolic blood pressure, interacts directly with genes involved in calcium-channel formation and the second gene, MAP4 , encodes a microtubule-associated protein and had already

  6. Property transfer assessments should include radon gas testing

    International Nuclear Information System (INIS)

    Nardi, M.A.

    1992-01-01

    There are two emerging influences that will require radon gas testing as part of many property transfers and most environmental assessments. These requirements come from lending regulators and state legislatures and affect single family, multifamily, and commercial properties. Fannie Mae and others have developed environmental investigation guidelines for protection from long term legal liabilities in the purchase of environmentally contaminated real estate. These guidelines include radon gas testing for many properties. Several states have enacted laws that require environmental disclosure forms be prepared to ensure that the parties involved in certain real estate transactions are aware of the environmental liabilities that may come with the transfer of property. Indiana has recently enacted legislation that would require the disclosure of the presence of radon gas on many commercial real estate transactions. With more banks and state governments following this trend, radon gas testing should be performed during all property transfers and environmental assessments to protect the parties involved from any long term legal liabilities

  7. Environmental site assessments should include radon gas testing

    International Nuclear Information System (INIS)

    Nardi, M.A.

    1991-01-01

    There are two emerging influences that will require radon gas testing as part of many property transfers and most site assessments. These requirements come from lending regulators and state legislatures. Fannie Mae and others have developed environmental investigation guidelines for the purchase of environmentally contaminated real estate. These guidelines include radon gas testing for many properties. Several states have enacted laws that require environmental disclosure forms be prepared to ensure that the parties involved in certain real estate transactions are aware of the environmental liabilities that may come with the transfer of property. Indiana has recently enacted legislation that would require the disclosure of the presence of radon gas on many commercial real estate transactions. With more lenders and state governments likely to follow this trend, radon gas testing should be performed during all property transfers and site assessment to protect the parties involved from any legal liabilities

  8. Standardised Testing and Assessment in Comprehensive School in Scandinavian Countries

    DEFF Research Database (Denmark)

    Andreasen, Karen Egedal; Eva, Hjörne,

    Assessments can be considered to be an integrated part of formal educational settings, in different forms and used for different purposes. In this contribution we will discuss and analyse the use of assessments in comprehensive school in Scandinavian countries through time, as we will include....... If the comprehensive school is based on the general idea of a school for all, how can different ways of practising assessment support or work against this idea? What conclusions can be drawn from the experiences in the Scandinavian countries?...... different kinds of documentary and empirical studies in the argumentation. We will focus on which kinds of assessments has been used, for which purposes and the role of this in the perspective of society. More contemporary trends will be discussed, specially the use of standardised testing. Scandinavian...

  9. Assessing clinical reasoning in optometry using the script concordance test.

    Science.gov (United States)

    Faucher, Caroline; Dufour-Guindon, Marie-Pier; Lapointe, Gabrielle; Gagnon, Robert; Charlin, Bernard

    2016-05-01

    Clinical reasoning is central to any health profession but its development among learners is difficult to assess. Over the last few decades, the script concordance test (SCT) has been developed to solve this dilemma and has been used in many health professions; however, no study has been published on the use of the script concordance test in optometry. The purpose of this study was to develop and validate a script concordance test for the field of optometry. A 101-question script concordance test (27 short clinical scenarios) was developed and administered online to a convenience sample of 23 second-year and 19 fourth-year students of optometry. It was also administered to a reference panel of 12 experienced optometrists to develop the scoring key. An item-total correlation was calculated for each question. Cronbach's alpha coefficient was used to evaluate the script concordance test reliability and a t-test compared the two groups. A final 77-question script concordance test was created by eliminating questions with low item-total correlation. Cronbach's alpha for this optimised 77-question script concordance test was 0.80. A group comparison revealed that the second-year students' scores (n = 23; mean score = 66.4 ± 7.87 per cent) were statistically lower (t = -4.141; p Optometry © 2016 Optometry Australia.

  10. Biomechanical assessment of dynamic balance: Specificity of different balance tests.

    Science.gov (United States)

    Ringhof, Steffen; Stein, Thorsten

    2018-04-01

    Dynamic balance is vitally important for most sports and activities of daily living, so the assessment of dynamic stability has become an important issue. In consequence, a large number of balance tests have been developed. However, it is not yet known whether these tests (i) measure the same construct and (ii) can differentiate between athletes with different balance expertise. We therefore studied three common dynamic balance tests: one-leg jump landings, Posturomed perturbations and simulated forward falls. Participants were 24 healthy young females in regular training in either gymnastics (n = 12) or swimming (n = 12). In each of the tests, the participants were instructed to recover balance as quickly as possible. Dynamic stability was computed by time to stabilization and margin of stability, deduced from force plates and motion capture respectively. Pearson's correlations between the dynamic balance tests found no significant associations between the respective dynamic stability measures. Furthermore, independent t-tests indicated that only jump landings could properly distinguish between both groups of athletes. In essence, the different dynamic balance tests applied did not measure the same construct but rather task-specific skills, each of which depends on multifactorial internal and external constraints. Our study therefore contradicts the traditional view of considering balance as a general ability, and reinforces that dynamic balance measures are not interchangeable. This highlights the importance of selecting appropriate balance tests. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. Development of a computerized adaptive test for Schizotypy assessment.

    Directory of Open Access Journals (Sweden)

    Eduardo Fonseca-Pedrero

    Full Text Available BACKGROUND: Schizotypal traits in adolescents from the general population represent the behavioral expression of liability for psychotic disorders. Schizotypy assessment in this sector of population has advanced considerably in the last few years; however, it is necessary to incorporate recent advances in psychological and educational measurement. OBJECTIVE: The main goal of this study was to develop a Computerized Adaptive Test (CAT to evaluate schizotypy through "The Oviedo Questionnaire for Schizotypy Assessment" (ESQUIZO-Q, in non-clinical adolescents. METHODS: The final sample consisted of 3,056 participants, 1,469 males, with a mean age of 15.9 years (SD=1.2. RESULTS: The results indicated that the ESQUIZO-Q scores presented adequate psychometric properties under both Classical Test Theory and Item Response Theory. The Information Function estimated using the Gradual Response Model indicated that the item pool effectively assesses schizotypy at the high end of the latent trait. The correlation between the CAT total scores and the paper-and-pencil test was 0.92. The mean number of presented items in the CAT with the standard error fixed at ≤ 0.30 was of 34 items. CONCLUSION: The CAT showed adequate psychometric properties for schizotypy assessment in the general adolescent population. The ESQUIZO-Q adaptive version could be used as a screening method for the detection of adolescents at risk for psychosis in both educational and mental health settings.

  12. Comparison of cough reflex test against instrumental assessment of aspiration.

    Science.gov (United States)

    Miles, Anna; Moore, Sara; McFarlane, Mary; Lee, Fiona; Allen, Jacqueline; Huckabee, Maggie-Lee

    2013-06-13

    Silent aspiration is associated with pneumonia and mortality, and is poorly identified by traditional clinical swallowing evaluation (CSE). The aim of this study was to validate cough reflex testing (CRT) for identification of silent aspiration against aspiration confirmed by instrumental assessment. Cough reflex threshold testing was completed on all patients using inhaled, nebulised citric acid. Within an hour, 80 patients underwent videofluoroscopic study of swallowing (VFSS) and 101 patients underwent fibreoptic endoscopic evaluation of swallowing (FEES). All tests were recorded and analysed by two researchers blinded to the result of the alternate test. Significant associations between CRT result and cough response to aspiration on VFSS (X(2) (2)=11.046, p=.003) and FEES (X(2) (2)=34.079, pacid provide a better predictive measure of silent aspiration. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. Reliability assessment for safety critical systems by statistical random testing

    International Nuclear Information System (INIS)

    Mills, S.E.

    1995-11-01

    In this report we present an overview of reliability assessment for software and focus on some basic aspects of assessing reliability for safety critical systems by statistical random testing. We also discuss possible deviations from some essential assumptions on which the general methodology is based. These deviations appear quite likely in practical applications. We present and discuss possible remedies and adjustments and then undertake applying this methodology to a portion of the SDS1 software. We also indicate shortcomings of the methodology and possible avenues to address to follow to address these problems. (author). 128 refs., 11 tabs., 31 figs

  14. Reliability assessment for safety critical systems by statistical random testing

    Energy Technology Data Exchange (ETDEWEB)

    Mills, S E [Carleton Univ., Ottawa, ON (Canada). Statistical Consulting Centre

    1995-11-01

    In this report we present an overview of reliability assessment for software and focus on some basic aspects of assessing reliability for safety critical systems by statistical random testing. We also discuss possible deviations from some essential assumptions on which the general methodology is based. These deviations appear quite likely in practical applications. We present and discuss possible remedies and adjustments and then undertake applying this methodology to a portion of the SDS1 software. We also indicate shortcomings of the methodology and possible avenues to address to follow to address these problems. (author). 128 refs., 11 tabs., 31 figs.

  15. Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water

    OpenAIRE

    N.V. Zaitseva; O.V. Dolgilh; A.V. Krivtsov; K.G. Starkova; V.A. Luchnikova; O.A. Bubnov; E.A. Otavina; N.V. Bezruchenko; N.A. Vdovina

    2015-01-01

    A sequencing of the candidate genes of the pupils, exposed to strontium by the method of targeted resequencing has been performed. It is shown, that under conditions of increased revenues of strontium in drinking water the number of polymorphonuclear altered portions of candidate genes increases. As a result of the targeted resequencing in conditions of strontium exposure, the maximum polymorph modifications of the following genes are defined: sulfotransferase 1A1 (SULT1A1) and methylenetetra...

  16. EEG INTERFACE MODULE FOR COGNITIVE ASSESSMENT THROUGH NEUROPHYSIOLOGIC TESTS

    Directory of Open Access Journals (Sweden)

    Kundan Lal Verma

    2014-12-01

    Full Text Available The cognitive signal processing is one of the important interdisciplinary field came from areas of life sciences, psychology, psychiatry, engi-neering, mathematics, physics, statistics and many other fields of research. Neurophysiologic tests are utilized to assess and treat brain injury, dementia, neurological conditions, and useful to investigate psychological and psychiatric disorders. This paper presents an ongoing research work on development of EEG interface device based on the principles of cognitive assessments and instrumentation. The method proposed engineering and science of cogni-tive signal processing in case of brain computer in-terface based neurophysiologic tests. The future scope of this study is to build a low cost EEG device for various clinical and pre-clinical applications with specific emphasis to measure the effect of cognitive action on human brain.

  17. Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care.

    Science.gov (United States)

    Vekemans, Johan; Marsh, Kevin; Greenwood, Brian; Leach, Amanda; Kabore, William; Soulanoudjingar, Solange; Asante, Kwaku Poku; Ansong, Daniel; Evans, Jennifer; Sacarlal, Jahit; Bejon, Philip; Kamthunzi, Portia; Salim, Nahya; Njuguna, Patricia; Hamel, Mary J; Otieno, Walter; Gesase, Samwel; Schellenberg, David

    2011-08-04

    An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation. An initial study of an RTS, S vaccine candidate showed promising efficacy against severe malaria in children in Mozambique. Further evidence of its protective efficacy will be gained in a pivotal, multi-centre, phase III study. This paper describes the case definitions of severe malaria used in this study and the programme for standardized assessment of severe malaria according to the case definition. Case definitions of severe malaria were developed from a literature review and a consensus meeting of expert consultants and the RTS, S Clinical Trial Partnership Committee, in collaboration with the World Health Organization and the Malaria Clinical Trials Alliance. The same groups, with input from an Independent Data Monitoring Committee, developed and implemented a programme for standardized data collection.The case definitions developed reflect the typical presentations of severe malaria in African hospitals. Markers of disease severity were chosen on the basis of their association with poor outcome, occurrence in a significant proportion of cases and on an ability to standardize their measurement across research centres. For the primary case definition, one or more clinical and/or laboratory markers of disease severity have to be present, four major co-morbidities (pneumonia, meningitis, bacteraemia or gastroenteritis with severe dehydration) are excluded, and a Plasmodium falciparum parasite density threshold is introduced, in order to maximize the specificity of the case definition. Secondary case definitions allow inclusion of co-morbidities and/or allow for the presence of parasitaemia at any density. The programmatic implementation of standardized case assessment included a clinical algorithm for evaluating seriously sick children

  18. Sound absorption of low-temperature reusable surface insulation candidate materials

    Science.gov (United States)

    Johnston, J. D.

    1974-01-01

    Sound absorption data from tests of four candidate low-temperature reusable surface insulation materials are presented. Limitations on the use of the data are discussed, conclusions concerning the effective absorption of the materials are drawn, and the relative significance to Vibration and Acoustic Test Facility test planning of the absorption of each material is assessed.

  19. Testing of an accident consequence assessment model using field data

    International Nuclear Information System (INIS)

    Homma, Toshimitsu; Matsubara, Takeshi; Tomita, Kenichi

    2007-01-01

    This paper presents the results obtained from the application of an accident consequence assessment model, OSCAAR to the Iput dose reconstruction scenario of BIOMASS and also to the Chernobyl 131 I fallout scenario of EMRAS, both organized by International Atomic Energy Agency. The Iput Scenario deals with 137 Cs contamination of the catchment basin and agricultural area in the Bryansk Region of Russia, which was heavily contaminated after the Chernobyl accident. This exercise was used to test the chronic exposure pathway models in OSCAAR with actual measurements and to identify the most important sources of uncertainty with respect to each part of the assessment. The OSCAAR chronic exposure pathway models had some limitations but the refined model, COLINA almost successfully reconstructed the whole 10-year time course of 137 Cs activity concentrations in most requested types of agricultural products and natural foodstuffs. The Plavsk scenario provides a good opportunity to test not only the food chain transfer model of 131 I but also the method of assessing 131 I thyroid burden. OSCAAR showed in general good capabilities for assessing the important 131 I exposure pathways. (author)

  20. The GP tests of competence assessment: which part best predicts fitness to practise decisions?

    Science.gov (United States)

    Jayaweera, Hirosha Keshani; Potts, Henry W W; Keshwani, Karim; Valerio, Chris; Baker, Magdalen; Mehdizadeh, Leila; Sturrock, Alison

    2018-01-02

    The General Medical Council (GMC) conducts Tests of Competence (ToC) for doctors referred for Fitness to Practise (FtP) issues. GPs take a single best answer knowledge test, an Objective Structured Clinical Examination (OSCE), and a Simulated Surgery (SimSurg) assessment which is a simulated GP consultation. The aim of this study was to examine the similarities between OSCEs and SimSurg to determine whether each assessment contributed something unique to GP ToCs. A mixed methods approach was used. Data were collated on 153 GPs who were required to undertake a ToC as a part of being investigated for FtP issues between February 2010 and October 2016. Using correlation analysis, we examined to what degree performance on the knowledge test, OSCE, and SimSurg related to case examiner recommendations and FtP outcomes, including the unique predictive power of these three assessments. The outcome measures were case examiner recommendations (i) not fit to practise; ii) fit to practise on a limited basis; or iii) fit to practise) as well as FtP outcomes (i) erased/removed from the register; ii) having restrictions/conditions; or iii) be in good standing). For the qualitative component, 45 GP assessors were asked to rate whether they assess the same competencies and which assessment provides better feedback about candidates. There was significant overlap between OSCEs and SimSurg, p < 0.001. SimSurg had additional predictive power in the presence of OSCEs and the knowledge test (p = 0.030) in distinguishing doctors from different FtP categories, while OSCEs did not (p = 0.080). Both the OSCEs (p = 0.004) and SimSurg (p < 0.001) had significant negative correlations with case examiner recommendations when accounting for the effects of the other two assessments. Inductive thematic analysis of the responses to the questionnaire showed that assessors perceived OSCEs to be better suited to target specific knowledge and skills. SimSurg was thought to produce a

  1. Pharmacology of biosimilar candidate drugs in rheumatology: a literature review.

    Science.gov (United States)

    Araújo, F; Cordeiro, I; Teixeira, F; Gonçalves, J; Fonseca, J E

    2014-01-01

    To review current evidence concerning pharmacology of biosimilar candidates to be used in rheumatology. A PubMed search up to August 2013 was performed using relevant search terms to include all studies assessing pharmacological properties of biosimilar candidates to be used in rheumatology. Data on study characteristics, type of intervention, pharmacokinetics (PK), pharmacodynamics (PD) and bioequivalence ratios was extracted. Of 280 articles screened, 5 fulfilled our inclusion criteria. Two trials, PLANETAS and PLANETRA, compared CT-P13 and infliximab in patients with active ankylosing spondylitis and rheumatoid arthritis, respectively. PK bioequivalence was demonstrated in the phase 1 PLANETAS trial by highly comparable area under the curve (AUC) and maximum drug concentrations (Cmax), whose geometric mean ratios fell between the accepted bioequivalence range of 80-125%. Equivalence in efficacy and safety was demonstrated in the phase 3 PLANETRA trial. Two phase 1 trials comparing etanercept biosimilar candidates TuNEX and HD203 in healthy volunteers showed a high degree of similarity in AUC and Cmax, with respective geometric mean ratios between PK bioequivalence range. The last included trial referred to GP2013, a rituximab biosimilar candidate, which demonstrated PK and PD bioequivalence to reference product in three different dosing regimens in cynomolgus monkeys. Infliximab, etanercept and rituximab biosimilar candidates have demonstrated PK bioequivalence in the trials included in this review. CT-P13 has recently been approved for use in the European market and the remaining biosimilar candidates are currently being tested in patients with rheumatoid arthritis.

  2. Validation of a Short Form of an Indecision Test: The Vocational Assessment Test

    Science.gov (United States)

    Picard, France; Frenette, Éric; Guay, Frédéric; Labrosse, Julie

    2015-01-01

    The purpose of this research was to validate the scores of a short form of a new instrument, "l'Épreuve de décision vocationnelle, forme scolaire" (EDV-9S; vocational assessment test), which measures six indecision-related problems (lack of self-knowledge, lack of readiness, lack of method in decision making, lack of information,…

  3. The International Test Commission Guidelines on the Security of Tests, Examinations, and Other Assessments

    Science.gov (United States)

    International Journal of Testing, 2016

    2016-01-01

    The amount and severity of security threats have increased considerably over the past two decades, calling into question the validity of assessments administered around the world. These threats have increased for a number of reasons, including the popular use of computerized and online technologies for test administration and the use of almost…

  4. Integrated testing strategy (ITS) for bioaccumulation assessment under REACH

    DEFF Research Database (Denmark)

    Lombardo, Anna; Roncaglioni, Alessandra; Benfentati, Emilio

    2014-01-01

    in a dossier. REACH promotes the use of alternative methods to replace, refine and reduce the use of animal (eco)toxicity testing. Within the EU OSIRIS project, integrated testing strategies (ITSs) have been developed for the rational use of non-animal testing approaches in chemical hazard assessment. Here we......REACH (registration, evaluation, authorisation and restriction of chemicals) regulation requires that all the chemicals produced or imported in Europe above 1 tonne/year are registered. To register a chemical, physicochemical, toxicological and ecotoxicological information needs to be reported...... present an ITS for evaluating the bioaccumulation potential of organic chemicals. The scheme includes the use of all available data (also the non-optimal ones), waiving schemes, analysis of physicochemical properties related to the end point and alternative methods (both in silico and in vitro). In vivo...

  5. Environmental assessment for Breeder Reprocessing Engineering Test (BRET): Revision 1

    International Nuclear Information System (INIS)

    Lerch, R.E.

    1989-03-01

    This Environmental Assessment (EA) is for the proposed installation and operation of an integrated breeder fuel reprocessing test system in the shielded cells of the Fuels and Materials Examination Facility (FMEF) at Hanford and the associated modifications to the FMEF to accommodate BRET. These modifications would begin in FY-1986 subject to Congressional authorization. Hot operations would be scheduled to start in the early 1990's. The system, called the Breeder Reprocessing Engineering Test (BRET), is being designed to provide a test capability for developing the demonstrating fuel reprocessing, remote maintenance, and safeguards technologies for breeder reactor fuels. This EA describes (1) the action being proposed, (2) the existing environment which would be affected, (3) the potential environmental impacts from normal operations and severe accidents from the proposed action, (4) potential conflicts with federal, state, regional, and/or local plans for the area, and (5) environmental implications of alternatives considered to the proposed action. 41 refs., 10 figs., 31 tabs

  6. Efficient Noninferiority Testing Procedures for Simultaneously Assessing Sensitivity and Specificity of Two Diagnostic Tests

    Directory of Open Access Journals (Sweden)

    Guogen Shan

    2015-01-01

    Full Text Available Sensitivity and specificity are often used to assess the performance of a diagnostic test with binary outcomes. Wald-type test statistics have been proposed for testing sensitivity and specificity individually. In the presence of a gold standard, simultaneous comparison between two diagnostic tests for noninferiority of sensitivity and specificity based on an asymptotic approach has been studied by Chen et al. (2003. However, the asymptotic approach may suffer from unsatisfactory type I error control as observed from many studies, especially in small to medium sample settings. In this paper, we compare three unconditional approaches for simultaneously testing sensitivity and specificity. They are approaches based on estimation, maximization, and a combination of estimation and maximization. Although the estimation approach does not guarantee type I error, it has satisfactory performance with regard to type I error control. The other two unconditional approaches are exact. The approach based on estimation and maximization is generally more powerful than the approach based on maximization.

  7. An in vitro human skin test for assessing sensitization potential.

    Science.gov (United States)

    Ahmed, S S; Wang, X N; Fielding, M; Kerry, A; Dickinson, I; Munuswamy, R; Kimber, I; Dickinson, A M

    2016-05-01

    Sensitization to chemicals resulting in an allergy is an important health issue. The current gold-standard method for identification and characterization of skin-sensitizing chemicals was the mouse local lymph node assay (LLNA). However, for a number of reasons there has been an increasing imperative to develop alternative approaches to hazard identification that do not require the use of animals. Here we describe a human in-vitro skin explant test for identification of sensitization hazards and the assessment of relative skin sensitizing potency. This method measures histological damage in human skin as a readout of the immune response induced by the test material. Using this approach we have measured responses to 44 chemicals including skin sensitizers, pre/pro-haptens, respiratory sensitizers, non-sensitizing chemicals (including skin-irritants) and previously misclassified compounds. Based on comparisons with the LLNA, the skin explant test gave 95% specificity, 95% sensitivity, 95% concordance with a correlation coefficient of 0.9. The same specificity and sensitivity were achieved for comparison of results with published human sensitization data with a correlation coefficient of 0.91. The test also successfully identified nickel sulphate as a human skin sensitizer, which was misclassified as negative in the LLNA. In addition, sensitizers and non-sensitizers identified as positive or negative by the skin explant test have induced high/low T cell proliferation and IFNγ production, respectively. Collectively, the data suggests the human in-vitro skin explant test could provide the basis for a novel approach for characterization of the sensitizing activity as a first step in the risk assessment process. Copyright © 2015 John Wiley & Sons, Ltd.

  8. An association study of 13 SNPs from seven candidate genes with pediatric asthma and a preliminary study for genetic testing by multiple variants in Taiwanese population.

    Science.gov (United States)

    Wang, Jiu-Yao; Liou, Ya-Huei; Wu, Ying-Jye; Hsiao, Ya-Hsin; Wu, Lawrence Shih-Hsin

    2009-03-01

    Asthma is one of the most common chronic diseases in children. It is caused by complex interactions between various genetic factors and exposures to environmental allergens and irritants. Because of the heterogeneity of the disease and the genetic and cultural differences among different populations, a proper association study and genetic testing for asthma and susceptibility genes is difficult to perform. We assessed 13 single-nucleotide polymorphisms (SNPs) in seven well-known asthma susceptibility genes and looked for association with pediatric asthma using 449 asthmatic subjects and 512 non-asthma subjects in Taiwanese population. CD14-159 C/T and MS4A2 Glu237Gly were identified to have difference in genotype/allele frequencies between the control group and asthma patients. Moreover, the genotype synergistic analysis showed that the co-contribution of two functional SNPs was riskier or more protective from asthma attack. Our study provided a genotype synergistic method for studying gene-gene interaction on polymorphism basis and genetic testing using multiple polymorphisms.

  9. The use of neuropsychological tests to assess intelligence.

    Science.gov (United States)

    Gansler, David A; Varvaris, Mark; Schretlen, David J

    We sought to derive a 'neuropsychological intelligence quotient' (NIQ) to replace IQ testing in some routine assessments. We administered neuropsychological testing and a seven-subtest short form of the Wechsler Adult Intelligence Scale to a community sample of 394 adults aged 18-96 years. We regressed Wechsler Full Scale IQs (W-FSIQ) on 23 neuropsychological scores and derived an NIQ from 9 measures that explained significant variance in W-FSIQ. We then compared subgroups of 284 healthy and 108 unhealthy participants in NIQ and W-FSIQ to assess criterion validity, correlated NIQ and W-FSIQ scores with education level and independence for activities of daily living to assess convergent validity, and compared validity coefficients for the NIQ with those of 'hold' and 'no-hold' indices. By design, NIQ and W-FSIQ scores correlated highly (r = .84), and both were higher in healthy participants. The difference was larger for NIQ, which accounted for more variability in activities of daily living. The NIQ and 'no-hold' index were better predicted by health status and less predicted by educational status than the 'hold' index. We constructed an NIQ that correlates highly with Wechsler FSIQ. Tests required to obtain NIQ are commonly used and can be administered in about 45 min. Validity properties of NIQ and W-FSIQ are similar. The NIQ bore greater resemblance to a 'no-hold' than 'hold' index. One can obtain a reasonably accurate estimate of current Full Scale IQ without formal intelligence testing from a brief neuropsychological battery.

  10. A virtual shopping test for realistic assessment of cognitive function.

    Science.gov (United States)

    Okahashi, Sayaka; Seki, Keiko; Nagano, Akinori; Luo, Zhiwei; Kojima, Maki; Futaki, Toshiko

    2013-06-18

    Cognitive dysfunction caused by brain injury often prevents a patient from achieving a healthy and high quality of life. By now, each cognitive function is assessed precisely by neuropsychological tests. However, it is also important to provide an overall assessment of the patients' ability in their everyday life. We have developed a Virtual Shopping Test (VST) using virtual reality technology. The objective of this study was to clarify 1) the significance of VST by comparing VST with other conventional tests, 2) the applicability of VST to brain-damaged patients, and 3) the performance of VST in relation to age differences. The participants included 10 patients with brain damage, 10 age-matched healthy subjects for controls, 10 old healthy subjects, and 10 young healthy subjects. VST and neuropsychological tests/questionnaires about attention, memory and executive function were conducted on the patients, while VST and the Mini-Mental State Examination (MMSE) were conducted on the controls and healthy subjects. Within the VST, the participants were asked to buy four items in the virtual shopping mall quickly in a rational way. The score for evaluation included the number of items bought correctly, the number of times to refer to hints, the number of movements between shops, and the total time spent to complete the shopping. Some variables on VST correlated with the scores of conventional assessment about attention and everyday memory. The mean number of times referring to hints and the mean number of movements were significantly larger for the patients with brain damage, and the mean total time was significantly longer for the patients than for the controls. In addition, the mean total time was significantly longer for the old than for the young. The results suggest that VST is able to evaluate the ability of attention and everyday memory in patients with brain damage. The time of VST is increased by age.

  11. Impacts Analyses Supporting the National Environmental Policy Act Environmental Assessment for the Resumption of Transient Testing Program

    Energy Technology Data Exchange (ETDEWEB)

    Annette L. Schafer; Lloyd C. Brown; David C. Carathers; Boyd D. Christensen; James J. Dahl; Mark L. Miller; Cathy Ottinger Farnum; Steven Peterson; A. Jeffrey Sondrup; Peter V. Subaiya; Daniel M. Wachs; Ruth F. Weiner

    2013-11-01

    Environmental and health impacts are presented for activities associated with transient testing of nuclear fuel and material using two candidate test reactors. Transient testing involves irradiation of nuclear fuel or materials for short time-periods under high neutron flux rates. The transient testing process includes transportation of nuclear fuel or materials inside a robust shipping cask to a hot cell, removal from the shipping cask, pre-irradiation examination of the nuclear materials, assembly of an experiment assembly, transportation of the experiment assembly to the test reactor, irradiation in the test reactor, transport back to the hot cell, and post-irradiation examination of the nuclear fuel or material. The potential for environmental or health consequences during the transportation, examination, and irradiation actions are assessed for normal operations, off-normal (accident) scenarios, and transportation. Impacts to the environment (air, soil, and groundwater), are assessed during each phase of the transient testing process. This report documents the evaluation of potential consequences to the general public. This document supports the Environmental Assessment (EA) required by the U.S. National Environmental Policy Act (NEPA) (42 USC Subsection 4321 et seq.).

  12. Development and assessment of molecular diagnostic tests for 15 enteropathogens causing childhood diarrhoea: a multicentre study.

    Science.gov (United States)

    Liu, Jie; Kabir, Furqan; Manneh, Jainaba; Lertsethtakarn, Paphavee; Begum, Sharmin; Gratz, Jean; Becker, Steve M; Operario, Darwin J; Taniuchi, Mami; Janaki, Lalitha; Platts-Mills, James A; Haverstick, Doris M; Kabir, Mamun; Sobuz, Shihab U; Nakjarung, Kaewkanya; Sakpaisal, Pimmada; Silapong, Sasikorn; Bodhidatta, Ladaporn; Qureshi, Shahida; Kalam, Adil; Saidi, Queen; Swai, Ndealilia; Mujaga, Buliga; Maro, Athanasia; Kwambana, Brenda; Dione, Michel; Antonio, Martin; Kibiki, Gibson; Mason, Carl J; Haque, Rashidul; Iqbal, Najeeha; Zaidi, Anita K M; Houpt, Eric R

    2014-08-01

    Childhood diarrhoea can be caused by many pathogens that are difficult to assay in the laboratory. Molecular diagnostic techniques provide a uniform method to detect and quantify candidate enteropathogens. We aimed to develop and assess molecular tests for identification of enteropathogens and their association with disease. We developed and assessed molecular diagnostic tests for 15 enteropathogens across three platforms-PCR-Luminex, multiplex real-time PCR, and TaqMan array card-at five laboratories worldwide. We judged the analytical and clinical performance of these molecular techniques against comparator methods (bacterial culture, ELISA, and PCR) using 867 diarrhoeal and 619 non-diarrhoeal stool specimens. We also measured molecular quantities of pathogens to predict the association with diarrhoea, by univariate logistic regression analysis. The molecular tests showed very good analytical and clinical performance at all five laboratories. Comparator methods had limited sensitivity compared with the molecular techniques (20-85% depending on the target) but good specificity (median 97·3%, IQR 96·5-98·9; mean 95·2%, SD 9·1). Positive samples by comparator methods usually had higher molecular quantities of pathogens than did negative samples, across almost all platforms and for most pathogens (pMolecular diagnostic tests can be implemented successfully and with fidelity across laboratories around the world. In the case of diarrhoea, these techniques can detect pathogens with high sensitivity and ascribe diarrhoeal associations based on quantification, including in mixed infections, providing rich and unprecedented measurements of infectious causes. Bill & Melinda Gates Foundation Next Generation Molecular Diagnostics Project. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Microscopic assessment of bone toughness using scratch tests

    Directory of Open Access Journals (Sweden)

    Amrita Kataruka

    2017-06-01

    Full Text Available Bone is a composite material with five distinct structural levels: collagen molecules, mineralized collagen fibrils, lamellae, osteon and whole bone. However, most fracture testing methods have been limited to the macroscopic scale and there is a need for advanced characterization methods to assess toughness at the osteon level and below. The goal of this investigation is to present a novel framework to measure the fracture properties of bone at the microscopic scale using scratch testing. A rigorous experimental protocol is articulated and applied to examine cortical bone specimens from porcine femurs. The observed fracture behavior is very complex: we observe a strong anisotropy of the response with toughening mechanisms and a competition between plastic flow and brittle fracture. The challenge consists then in applying nonlinear fracture mechanics methods such as the J-integral or the energetic Size Effect Law to quantify the fracture toughness in a rigorous fashion. Our result suggests that mixed-mode fracture is instrumental in determining the fracture resistance. There is also a pronounced coupling between fracture and elasticity. Our methodology opens the door to fracture assessment at multiple structural levels, microscopic and potentially nanometer length scale, due to the scalability of scratch tests.

  14. Assessment of Replacement Bridge using Proof Load Test

    Science.gov (United States)

    Sundru, Saibabu

    2017-11-01

    This work begins with an overview of the condition assessment of old bridge and explained reasons for demolishing of the bridge. Briefly presented flexural analysis of two stage post-tensioned prestressed concrete girder, which will be replace the old (new bridge). Construction of I-girder and composite girder at first stage and second stage prestressing respectively is explained with figures. Assessment of the load-caring capacity of the one span of the replacement bridge with simple supports using proof load test is presented which is mandatory according to Indian standards. Weighted sand bags were used to load the bridge up to a predetermined service load with impact factor. Deflections of the I-girders of the bridge were measured at selected locations along and across the bridge span and compared with computed values. Linear response was observed during loading and unloading. Considering the load test results, theoretical estimation and criteria as stipulated in codes of practice, it can be inferred that prestressed concrete I-girder bridge span has adequate capacity to carry the loads and hence, deemed to have passed the test.

  15. Elastodynamic spot testing - assessing serviceability of aging elastomer parts

    International Nuclear Information System (INIS)

    Gracie, B.; Metcalfe, R.; Wensel, R.

    1995-01-01

    The properties of all polymers change with time as a function of their environment. Traditional practice has been to replace these parts according to generic time limits based on estimates of worst case material properties and conditions. This is overly-conservative in many cases, and creates unnecessary maintenance work and costs for replacement and disposal. Much of this could be avoided if the serviceability of elastomeric parts such as seals, diaphragms, gaskets, cable insulation and hoses could be reassessed on a routine basis. Elastodynamic spot testing offers a way to do this. Parts can be sampled while in service or storage to compare their as-new and used (or aged) elastodynamic properties. This data can usually be correlated with the results of functional tests to prove that material properties have not degraded to the point where the part could fail. This spot testing is similar to a micro-hardness test, but includes stress-relaxation and subsequent recovery. It provides a nondestructive means to assess the effective age of the material at a point, or several points, on a part. Sampling of hardness alone is rarely sufficient to know whether a part is still functional because this overlooks the material's viscoelastic and strength properties. An elastodynamic spot tester has been used to test different sizes, shapes and hardnesses of elastomeric parts at different levels of strain, i.e., indentation depths. An initial test program has given informative relaxation and recovery data, showing repeatability and comparing well with finite element analysis of the indentation process. Tests of aged 0-rings and diaphragms have revealed different elastodynamic properties, depending on the elastomer compound and aging conditions. (author)

  16. Application of calorimetry to the assessment of the performance of ITER Nb3Sn TF conductor samples in SULTAN tests

    International Nuclear Information System (INIS)

    Richard, L Savoldi; Zanino, R

    2008-01-01

    In the frame of the International Thermonuclear Experimental Reactor (ITER), several short full-size Nb 3 Sn samples of candidate toroidal field (TF) conductors were tested in 2007 at the SULTAN facility, PSI Villigen, Switzerland, in conditions relevant to the ITER TF (background magnetic field of 10.78 T and transport current of 68 kA). The performance of a SULTAN sample is determined by the current sharing temperature T CS . This can be obtained in principle from voltage measurements along the conductor sample, but the procedure is not free of issues and ambiguities. Here a complementary approach, based on the calorimetric assessment of the Joule heating due to current sharing, is critically discussed. Suitable algorithms are defined and the respective error bars are estimated, also based on numerical thermal-hydraulic modeling. The calorimetric approach is then applied to assess the performance of the samples tested in 2007 and compared with the results of the standard (electrical) approach

  17. PERSONALITY AND CLINICAL TESTS IN SPANISH FOR ASSESSING JUVENILE OFFENDERS

    Directory of Open Access Journals (Sweden)

    Lorena Wenger

    2016-05-01

    Full Text Available The psychological assessment of offenders throughout the different stages in the juvenile justice system is essential. It ensures the adequacy of the legal and educational measures to be applied in the process. This paper reviews the main tests of psychological assessment available in Spanish, suitable for use by psychology professionals who work with young offenders in the juvenile justice services in Spanish-speaking countries. We classify these tools into three groups: a personological, i.e. generic tools, suitable for any professional context in psychology, b clinical, i.e. tools whose initial use has been limited to working with adolescents with mental health needs, and c forensic, tools that have been specially developed for use in the juvenile justice population. This last group is described in the second part of this article (which appears in this same issue. The most important instruments of proven utility are presented and reviewed for each group.

  18. FORENSIC TESTS IN SPANISH FOR ASSESSING JUVENILE OFFENDERS

    Directory of Open Access Journals (Sweden)

    Lorena Wenger

    2016-05-01

    Full Text Available Objectively and rigorously understanding the individual psychological characteristics of adolescent offenders, such as intelligence, personality traits and others of a clinical and criminological nature, is essential when developing appropriate processes for intervention in educational and judicial measures in the context of juvenile justice. However, the clinical and personological tools described in the previous article (Wenger & Andrés-Pueyo, 2016 are not enough to address the criminogenic needs of the adolescents and other, more specific, tools are needed. In this article, a number of complementary instruments developed specifically for the forensic area are reviewed. These tools enable us to carry out very specific assessments in this context, such as the evaluation of the risk of violence or the assessment of psychopathy. A review is also presented of the forensic psychological tests available in Spanish for professionals in the field of juvenile justice.

  19. End-preparation assessments and tests for compounded sterile preparations.

    Science.gov (United States)

    McElhiney, Linda F

    2013-01-01

    Outsourcing has become a necessity to obtain sterile products that are currently on backorder. Because of the expense of outsourcing sterile compounding, pharmacy leadership in health systems are now considering the option of insourcing and batch preparing compounded sterile preparations, which can be a viable option for a health system. It can significantly decrease drug-spending costs, and the pharmacy has a complete record of the compounding process. The key to preparing high-quality, safe, sterile preparations and meeting United States Pharmacopeia standards is end-preparation assessments and tests.

  20. Assessing Differential Item Functioning on the Test of Relational Reasoning

    Directory of Open Access Journals (Sweden)

    Denis Dumas

    2018-03-01

    Full Text Available The test of relational reasoning (TORR is designed to assess the ability to identify complex patterns within visuospatial stimuli. The TORR is designed for use in school and university settings, and therefore, its measurement invariance across diverse groups is critical. In this investigation, a large sample, representative of a major university on key demographic variables, was collected, and the resulting data were analyzed using a multi-group, multidimensional item-response theory model-comparison procedure. No significant differential item functioning was found on any of the TORR items across any of the demographic groups of interest. This finding is interpreted as evidence of the cultural fairness of the TORR, and potential test-development choices that may have contributed to that cultural fairness are discussed.

  1. Testing of Method for Assessing of Room Thermal Stability

    Directory of Open Access Journals (Sweden)

    Charvátová Hana

    2017-01-01

    Full Text Available The paper presents the interim results of our research on the developing methodological procedure which could be used for assessment of a thermal stability of buildings with regards to its thermal accumulative parameters. The principle of testing is based on a combination of computer simulation of cooled room model developed in COMSOL Multiphysics software and on theoretical calculations with respect to compliance with valid European and Czech technical standards used in building industry and architecture under conditions obtained by real measurement for the room to be tested. The presented example shows the effect of the heataccumulation properties of the outside wall insulation materials on the course of the cooling room for winter conditions.

  2. Test Methodologies for Hydrogen Sensor Performance Assessment: Chamber vs. Flow Through Test Apparatus: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Buttner, William J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Hartmann, Kevin S [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Schmidt, Kara [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Cebolla, Rafeal O [Joint Research Centre, Petten, the Netherlands; Weidner, Eveline [Joint Research Centre, Petten, the Netherlands; Bonato, Christian [Joint Research Centre, Petten, the Netherlands

    2017-11-06

    Certification of hydrogen sensors to standards often prescribes using large-volume test chambers [1, 2]. However, feedback from stakeholders such as sensor manufacturers and end-users indicate that chamber test methods are often viewed as too slow and expensive for routine assessment. Flow through test methods potentially are an efficient, cost-effective alternative for sensor performance assessment. A large number of sensors can be simultaneously tested, in series or in parallel, with an appropriate flow through test fixture. The recent development of sensors with response times of less than 1s mandates improvements in equipment and methodology to properly capture the performance of this new generation of fast sensors; flow methods are a viable approach for accurate response and recovery time determinations, but there are potential drawbacks. According to ISO 26142 [1], flow through test methods may not properly simulate ambient applications. In chamber test methods, gas transport to the sensor can be dominated by diffusion which is viewed by some users as mimicking deployment in rooms and other confined spaces. Alternatively, in flow through methods, forced flow transports the gas to the sensing element. The advective flow dynamics may induce changes in the sensor behaviour relative to the quasi-quiescent condition that may prevail in chamber test methods. One goal of the current activity in the JRC and NREL sensor laboratories [3, 4] is to develop a validated flow through apparatus and methods for hydrogen sensor performance testing. In addition to minimizing the impact on sensor behaviour induced by differences in flow dynamics, challenges associated with flow through methods include the ability to control environmental parameters (humidity, pressure and temperature) during the test and changes in the test gas composition induced by chemical reactions with upstream sensors. Guidelines on flow through test apparatus design and protocols for the evaluation of

  3. Safety re-assessment of AECL test and research reactors

    International Nuclear Information System (INIS)

    Winfield, D.J.

    1990-01-01

    Atomic Energy of Canada Limited currently has four operating engineering test/research reactors of various sizes and ages; a new isotope-production reactor Maple-X10, under construction at Chalk River Nuclear Laboratories (CRNL), and a heating demonstration reactor, SDR, undergoing high-power commissioning at Whiteshell Nuclear Research Establishment (WNRE). The company is also performing design studies of small reactors for hot water and electricity production. The older reactors are ZED-2, PTR, NRX, and NRU; these range in age from 42 years (NRX) to 29 years (ZED-2). Since 1984, limited-scope safety re-assessments have been underway on three of these reactors (ZED-2, NRX AND NRU). ZED-2 and PTR are operated by the Reactor Physics Branch; all other reactors are operated by the respective site Reactor Operations Branches. For the older reactors the original safety reports produced were entirely deterministic in nature and based on the design-basis accident concept. The limited scope safety re-assessments for these older reactors, carried out over the past 5 years, have comprised both quantitative probabilistic safety-assessment techniques, such as event tree and fault analysis, and/or qualitative techniques, such as failure mode and effect analysis. The technique used for an individual assessment was dependent upon the specific scope required. This paper discusses the types of analyses carried out, specific insights/recommendations resulting from the analysis, and the plan for future analysis. In addition, during the last four years safety assessments have been carried out on the new isotope-, heat-, and electricity-producing reactors, as part of the safety design review, commissioning and licensing activities

  4. Assessment of ADHD Documentation from Candidates Requesting Americans with Disabilities Act (ADA) Accommodations for the National Board of Osteopathic Medical Examiners COMLEX Exam

    Science.gov (United States)

    Joy, Javed A.; Julius, Rose J.; Akter, Rashida; Baron, David A.

    2010-01-01

    Purpose: Every year increasing numbers of candidates request special accommodations for high-stakes medical licensing examinations, due to ADHD, on the basis of the Americans with Disabilities Act (ADA). This poses significant challenges for both the applicant and the medical boards and has significant financial, legal, and ethical implications.…

  5. Safety testing of monoclonal antibodies in non-human primates: Case studies highlighting their impact on human risk assessment.

    Science.gov (United States)

    Brennan, Frank R; Cavagnaro, Joy; McKeever, Kathleen; Ryan, Patricia C; Schutten, Melissa M; Vahle, John; Weinbauer, Gerhard F; Marrer-Berger, Estelle; Black, Lauren E

    2018-01-01

    Monoclonal antibodies (mAbs) are improving the quality of life for patients suffering from serious diseases due to their high specificity for their target and low potential for off-target toxicity. The toxicity of mAbs is primarily driven by their pharmacological activity, and therefore safety testing of these drugs prior to clinical testing is performed in species in which the mAb binds and engages the target to a similar extent to that anticipated in humans. For highly human-specific mAbs, this testing often requires the use of non-human primates (NHPs) as relevant species. It has been argued that the value of these NHP studies is limited because most of the adverse events can be predicted from the knowledge of the target, data from transgenic rodents or target-deficient humans, and other sources. However, many of the mAbs currently in development target novel pathways and may comprise novel scaffolds with multi-functional domains; hence, the pharmacological effects and potential safety risks are less predictable. Here, we present a total of 18 case studies, including some of these novel mAbs, with the aim of interrogating the value of NHP safety studies in human risk assessment. These studies have identified mAb candidate molecules and pharmacological pathways with severe safety risks, leading to candidate or target program termination, as well as highlighting that some pathways with theoretical safety concerns are amenable to safe modulation by mAbs. NHP studies have also informed the rational design of safer drug candidates suitable for human testing and informed human clinical trial design (route, dose and regimen, patient inclusion and exclusion criteria and safety monitoring), further protecting the safety of clinical trial participants.

  6. Use of Six Sigma Worksheets for assessment of internal and external failure costs associated with candidate quality control rules for an ADVIA 120 hematology analyzer.

    Science.gov (United States)

    Cian, Francesco; Villiers, Elisabeth; Archer, Joy; Pitorri, Francesca; Freeman, Kathleen

    2014-06-01

    Quality control (QC) validation is an essential tool in total quality management of a veterinary clinical pathology laboratory. Cost-analysis can be a valuable technique to help identify an appropriate QC procedure for the laboratory, although this has never been reported in veterinary medicine. The aim of this study was to determine the applicability of the Six Sigma Quality Cost Worksheets in the evaluation of possible candidate QC rules identified by QC validation. Three months of internal QC records were analyzed. EZ Rules 3 software was used to evaluate candidate QC procedures, and the costs associated with the application of different QC rules were calculated using the Six Sigma Quality Cost Worksheets. The costs associated with the current and the candidate QC rules were compared, and the amount of cost savings was calculated. There was a significant saving when the candidate 1-2.5s, n = 3 rule was applied instead of the currently utilized 1-2s, n = 3 rule. The savings were 75% per year (£ 8232.5) based on re-evaluating all of the patient samples in addition to the controls, and 72% per year (£ 822.4) based on re-analyzing only the control materials. The savings were also shown to change accordingly with the number of samples analyzed and with the number of daily QC procedures performed. These calculations demonstrated the importance of the selection of an appropriate QC procedure, and the usefulness of the Six Sigma Costs Worksheet in determining the most cost-effective rule(s) when several candidate rules are identified by QC validation. © 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology.

  7. Laboratory tests for assessing adaptability and stickiness of dental composites.

    Science.gov (United States)

    Rosentritt, Martin; Buczovsky, Sebastian; Behr, Michael; Preis, Verena

    2014-09-01

    Handling (stickiness, adaptability) of a dental composite does strongly influence quality and success of a dental restoration. The purpose was to develop an in vitro test, which allows for evaluating adaptability and stickiness. 15 dentists were asked for providing individual assessment (school scores 1-6) of five dental composites addressing adaptability and stickiness. Composites were applied with a dental plugger (d=1.8 mm) in a class I cavity (human tooth 17). The tooth was fixed on a force gauge for simultaneous determination of application forces with varying storage (6/25°C) and application temperatures (6/25°C). On basis of these data tensile tests were performed with a dental plugger (application force 1N/2N; v=35 mm/min) on PMMA- or human tooth plates. Composite was dosed onto the tip of the plugger and applied. Application and unplugging was performed once and unplugging forces (UF) and length of the adhesive flags (LAF) were determined at different storage (6/25°C) and application temperatures (25/37°C). Unplugging work (UW) was calculated from area of UF and LAF data. The individual assessment revealed significantly different temperature-dependent application forces between 0.58 N and 2.23 N. Adaptability was assessed between 2.1 and 2.8 school scores. Stickiness varied significantly between the materials (scores: 2-3.2). UW differed significantly between the materials with values between 3.20 N mm and 37.83 N mm. Between PMMA substrate or tooth slides and between 1N or 2N application force only small UW differences were found. The presented in vitro unplugging work allows for an in vitro estimation of the handling parameters adaptability and stickiness. Copyright © 2014 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  8. Assessing high reliability via Bayesian approach and accelerated tests

    International Nuclear Information System (INIS)

    Erto, Pasquale; Giorgio, Massimiliano

    2002-01-01

    Sometimes the assessment of very high reliability levels is difficult for the following main reasons: - the high reliability level of each item makes it impossible to obtain, in a reasonably short time, a sufficient number of failures; - the high cost of the high reliability items to submit to life tests makes it unfeasible to collect enough data for 'classical' statistical analyses. In the above context, this paper presents a Bayesian solution to the problem of estimation of the parameters of the Weibull-inverse power law model, on the basis of a limited number (say six) of life tests, carried out at different stress levels, all higher than the normal one. The over-stressed (i.e. accelerated) tests allow the use of experimental data obtained in a reasonably short time. The Bayesian approach enables one to reduce the required number of failures adding to the failure information the available a priori engineers' knowledge. This engineers' involvement conforms to the most advanced management policy that aims at involving everyone's commitment in order to obtain total quality. A Monte Carlo study of the non-asymptotic properties of the proposed estimators and a comparison with the properties of maximum likelihood estimators closes the work

  9. A test-bed modeling study for wave resource assessment

    Science.gov (United States)

    Yang, Z.; Neary, V. S.; Wang, T.; Gunawan, B.; Dallman, A.

    2016-02-01

    Hindcasts from phase-averaged wave models are commonly used to estimate standard statistics used in wave energy resource assessments. However, the research community and wave energy converter industry is lacking a well-documented and consistent modeling approach for conducting these resource assessments at different phases of WEC project development, and at different spatial scales, e.g., from small-scale pilot study to large-scale commercial deployment. Therefore, it is necessary to evaluate current wave model codes, as well as limitations and knowledge gaps for predicting sea states, in order to establish best wave modeling practices, and to identify future research needs to improve wave prediction for resource assessment. This paper presents the first phase of an on-going modeling study to address these concerns. The modeling study is being conducted at a test-bed site off the Central Oregon Coast using two of the most widely-used third-generation wave models - WaveWatchIII and SWAN. A nested-grid modeling approach, with domain dimension ranging from global to regional scales, was used to provide wave spectral boundary condition to a local scale model domain, which has a spatial dimension around 60km by 60km and a grid resolution of 250m - 300m. Model results simulated by WaveWatchIII and SWAN in a structured-grid framework are compared to NOAA wave buoy data for the six wave parameters, including omnidirectional wave power, significant wave height, energy period, spectral width, direction of maximum directionally resolved wave power, and directionality coefficient. Model performance and computational efficiency are evaluated, and the best practices for wave resource assessments are discussed, based on a set of standard error statistics and model run times.

  10. Leadership scheme to develop the careers of talented candidates.

    Science.gov (United States)

    Lynas, Karen

    2012-02-01

    The Top Leaders programme supports career development by identifying talented staff and equipping them with a range of management skills and approaches. The programme uses a diagnostic test to help candidates assess their strengths, leadership styles and development needs, and offers them 360 degrees feedback. This enables them to identify areas they need to develop to be effective and supportive leaders. Two case studies illustrate the programme in action.

  11. Can water quality of tubewells be assessed without chemical testing?

    Science.gov (United States)

    Hoque, Mohammad A.; Butler, Adrian P.

    2016-04-01

    Arsenic is one of the major pollutants found in aquifers on a global scale. The screening of tubewells for arsenic has helped many people to avoid drinking from highly polluted wells in the Bengal Delta (West Bengal and Bangladesh). However, there are still many millions of tubewells in Bangladesh yet to be tested, and a substantial proportion of these are likely to contain excessive arsenic. Due to the level of poverty and lack of infrastructure, it is unlikely that the rest of the tubewells will be tested quickly. However, water quality assessment without needing a chemical testing may be helpful in this case. Studies have found that qualitative factors, such as staining in the tubewell basement and/or on utensils, can indicate subsurface geology and water quality. The science behind this staining is well established, red staining is associated with iron reduction leading to release of arsenic whilst black staining is associated with manganese reduction (any release of arsenic due to manganese reduction is sorbed back on the, yet to be reduced, iron), whereas mixed staining may indicate overlapping manganese and iron reduction at the tubewell screen. Reduction is not uniform everywhere and hence chemical water quality including dissolved arsenic varies from place to place. This is why coupling existing tubewell arsenic information with user derived staining data could be useful in predicting the arsenic status at a particular site. Using well location, depth, along with colour of staining, an assessment of both good (nutrients) and bad (toxins and pathogens) substances in the tubewell could be provided. Social-network technology, combined with increasing use of smartphones, provides a powerful opportunity for both sharing and providing feedback to the user. Here we outline how a simple digital application can couple the reception both qualitative and quantitative tubewell data into a centralised interactive database and provide manipulated feedback to an

  12. Objective assessment of gender roles: Gender Roles Test (GRT-36).

    Science.gov (United States)

    Fernández, Juan; Quiroga, M Angeles; del Olmo, Isabel; Aróztegui, Javier; Martín, Arantxa

    2011-11-01

    This study was designed to develop a computerized test to assess gender roles. This test is presented as a decision-making task to mask its purpose. Each item displays a picture representing an activity and a brief sentence that describes it. Participants have to choose the most suitable sex to perform each activity: man or woman. The test (Gender Roles Test, GRT-36) consists of 36 items/activities. The program registers both the choices made and their response times (RTs). Responses are considered as stereotyped when the chosen sex fits stereotyped roles and non-stereotyped when the chosen sex does not fit stereotyped roles. Individual means (RTs) were computed for stereotyped and non-stereotyped responses, differentiating between domestic and work spheres. A "D" score, reflecting the strength of association between activities and sex, was calculated for each sphere and sex. The study incorporated 78 participants (69% women and 31% men) ranging from 19 to 59 years old. The results show that: (a) reading speed does not explain the variability in the RTs; (b) RTs show good internal consistency; (c) RTs are shorter for stereotyped than for neutral stimuli; (d) RTs are shorter for stereotyped than for non-stereotyped responses. Intended goals are supported by obtained results. Scores provided by the task facilitate both group and individual detailed analysis of gender role, differentiating the gender role assigned to men from that assigned to women, at the domestic and work spheres. Obtained data fall within the scope of the genderology and their implications are discussed.

  13. Non-destructive testing for plant life assessment

    International Nuclear Information System (INIS)

    2005-01-01

    The International Atomic Energy Agency (IAEA) is promoting industrial applications of nondestructive testing (NDT) technology, which includes radiography testing (RT) and related methods, to assure safety and reliability of operation of industrial facilities and processes. NDT technology is essentially needed for improvement of the quality of industrial products, safe performance of equipment and plants, including safety of metallic and concrete structures and constructions. The IAEA is playing an important role in promoting the NDT use and technology support to Member States, in harmonisation for training and certification of NDT personnel, and in establishing national accreditation and certifying bodies. All these efforts have led to a stage of maturity and self sufficiency in numerous countries especially in the field of training and certification of personnel, and in provision of services to industries. This has had a positive impact on the improvement of the quality of industrial goods and services. NDT methods are primarily used for detection, location and sizing of surface and internal defects (in welds, castings, forging, composite materials, concrete and many more). Various NDT methods are applied for preventive maintenance (aircraft, bridge), for the inspection of raw materials, half-finished and finished products, for in-service-inspection and for plant life assessment studies. NDT is essential for quality control of the facilities and products, and for fitness - for purpose assessment (so-called plant life assessment). NDT evaluates remaining operation life of plant components (processing lines, pipes, vessels) providing an accurate diagnosis that allows predicting extended life operation beyond design life. Status and trends on the NDT for plant life assessment have been discussed in many IAEA meetings related with NDT development, training and education. Experts have largely demonstrated that, using NDT methods, a comprehensive assessment of the life

  14. Upper limb assessment using a Virtual Peg Insertion Test.

    Science.gov (United States)

    Fluet, Marie-Christine; Lambercy, Olivier; Gassert, Roger

    2011-01-01

    This paper presents the initial evaluation of a Virtual Peg Insertion Test developed to assess sensorimotor functions of arm and hand using an instrumented tool, virtual reality and haptic feedback. Nine performance parameters derived from kinematic and kinetic data were selected and compared between two groups of healthy subjects performing the task with the dominant and non-dominant hand, as well as with a group of chronic stroke subjects suffering from different levels of upper limb impairment. Results showed significantly smaller grasping forces applied by the stroke subjects compared to the healthy subjects. The grasping force profiles suggest a poor coordination between position and grasping for the stroke subjects, and the collision forces with the virtual board were found to be indicative of sensory deficits. These preliminary results suggest that the analyzed parameters could be valid indicators of impairment. © 2011 IEEE

  15. WIPP [Waste Isolation Pilot Plant] test phase plan: Performance assessment

    International Nuclear Information System (INIS)

    1990-04-01

    The U.S. Department of Energy (DOE) is responsible for managing the disposition of transuranic (TRU) wastes resulting from nuclear weapons production activities of the United States. These wastes are currently stored nationwide at several of the DOE's waste generating/storage sites. The goal is to eliminate interim waste storage and achieve environmentally and institutionally acceptable permanent disposal of these TRU wastes. The Waste Isolation Pilot Plant (WIPP) in southeastern New Mexico is being considered as a disposal facility for these TRU wastes. This document describes the first of the following two major programs planned for the Test Phase of WIPP: Performance Assessment -- determination of the long-term performance of the WIPP disposal system in accordance with the requirements of the EPA Standard; and Operations Demonstration -- evaluation of the safety and effectiveness of the DOE TRU waste management system's ability to emplace design throughput quantities of TRU waste in the WIPP underground facility. 120 refs., 19 figs., 8 tabs

  16. Functional validation of candidate genes detected by genomic feature models

    DEFF Research Database (Denmark)

    Rohde, Palle Duun; Østergaard, Solveig; Kristensen, Torsten Nygaard

    2018-01-01

    to investigate locomotor activity, and applied genomic feature prediction models to identify gene ontology (GO) cate- gories predictive of this phenotype. Next, we applied the covariance association test to partition the genomic variance of the predictive GO terms to the genes within these terms. We...... then functionally assessed whether the identified candidate genes affected locomotor activity by reducing gene expression using RNA interference. In five of the seven candidate genes tested, reduced gene expression altered the phenotype. The ranking of genes within the predictive GO term was highly correlated......Understanding the genetic underpinnings of complex traits requires knowledge of the genetic variants that contribute to phenotypic variability. Reliable statistical approaches are needed to obtain such knowledge. In genome-wide association studies, variants are tested for association with trait...

  17. Polymorphism’s assessment of children’s candidate genes associated with low-level long-term exposure to strontium in drinking water

    Directory of Open Access Journals (Sweden)

    N.V. Zaitseva

    2015-12-01

    Full Text Available A sequencing of the candidate genes of the pupils, exposed to strontium by the method of targeted resequencing has been performed. It is shown, that under conditions of increased revenues of strontium in drinking water the number of polymorphonuclear altered portions of candidate genes increases. As a result of the targeted resequencing in conditions of strontium exposure, the maximum polymorph modifications of the following genes are defined: sulfotransferase 1A1 (SULT1A1 and methylenetetrahydrofolate. It was shown that the structure of the mutations in conditions of the strontium exposure was characterized by the formation of defects in the gene mapping detoxification (38.5 % of all mutations and immunoregulation (22.5 %. Analysis of the cause-effect relationships in the system "factor - the number of mutations" revealed that candidate genes reflecting strontium exposure conditions (content of strontium in drinking water is 1.3 MAC, are genes: cytochrome P450, glutathione - transaminase (detoxification; dopamine (CNS, interleukin 17 and the major histocompatibility complex (immune system, methylene-tetra-hydro-folate-reductase (reproduction.

  18. Evolutions in clinical reasoning assessment: The Evolving Script Concordance Test.

    Science.gov (United States)

    Cooke, Suzette; Lemay, Jean-François; Beran, Tanya

    2017-08-01

    Script concordance testing (SCT) is a method of assessment of clinical reasoning. We developed a new type of SCT case design, the evolving SCT (E-SCT), whereby the patient's clinical story is "evolving" and with thoughtful integration of new information at each stage, decisions related to clinical decision-making become increasingly clear. We aimed to: (1) determine whether an E-SCT could differentiate clinical reasoning ability among junior residents (JR), senior residents (SR), and pediatricians, (2) evaluate the reliability of an E-SCT, and (3) obtain qualitative feedback from participants to help inform the potential acceptability of the E-SCT. A 12-case E-SCT, embedded within a 24-case pediatric SCT (PaedSCT), was administered to 91 pediatric residents (JR: n = 50; SR: n = 41). A total of 21 pediatricians served on the panel of experts (POE). A one-way analysis of variance (ANOVA) was conducted across the levels of experience. Participants' feedback on the E-SCT was obtained with a post-test survey and analyzed using two methods: percentage preference and thematic analysis. Statistical differences existed across levels of training: F = 19.31 (df = 2); p decision-making process. The E-SCT demonstrated very good reliability and was effective in distinguishing clinical reasoning ability across three levels of experience. Participants found the E-SCT engaging and representative of real-life clinical reasoning and decision-making processes. We suggest that further refinement and utilization of the evolving style case will enhance SCT as a robust, engaging, and relevant method for the assessment of clinical reasoning.

  19. WSEAT Shock Testing Margin Assessment Using Energy Spectra Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Sisemore, Carl; Babuska, Vit; Booher, Jason

    2018-02-01

    Several programs at Sandia National Laboratories have adopted energy spectra as a metric to relate the severity of mechanical insults to structural capacity. The purpose being to gain insight into the system's capability, reliability, and to quantify the ultimate margin between the normal operating envelope and the likely system failure point -- a system margin assessment. The fundamental concern with the use of energy metrics was that the applicability domain and implementation details were not completely defined for many problems of interest. The goal of this WSEAT project was to examine that domain of applicability and work out the necessary implementation details. The goal of this project was to provide experimental validation for the energy spectra based methods in the context of margin assessment as they relate to shock environments. The extensive test results concluded that failure predictions using energy methods did not agree with failure predictions using S-N data. As a result, a modification to the energy methods was developed following the form of Basquin's equation to incorporate the power law exponent for fatigue damage. This update to the energy-based framework brings the energy based metrics into agreement with experimental data and historical S-N data.

  20. Development of the Test Of Astronomy STandards (TOAST) Assessment Instrument

    Science.gov (United States)

    Slater, Timothy F.; Slater, S. J.

    2008-05-01

    Considerable effort in the astronomy education research (AER) community over the past several years has focused on developing assessment tools in the form of multiple-choice conceptual diagnostics and content knowledge surveys. This has been critically important in advancing the AER discipline so that researchers could establish the initial knowledge state of students as well as to attempt measure some of the impacts of innovative instructional interventions. Unfortunately, few of the existing instruments were constructed upon a solid list of clearly articulated and widely agreed upon learning objectives. This was not done in oversight, but rather as a result of the relative youth of AER as a discipline. Now that several important science education reform documents exist and are generally accepted by the AER community, we are in a position to develop, validate, and disseminate a new assessment instrument which is tightly aligned to the consensus learning goals stated by the American Astronomical Society - Chair's Conference on ASTRO 101, the American Association of the Advancement of Science's Project 2061 Benchmarks, and the National Research Council's National Science Education Standards. In response, researchers from the Cognition in Astronomy, Physics and Earth sciences Research (CAPER) Team at the University of Wyoming's Science & Math Teaching Center (UWYO SMTC) have designed a criterion-referenced assessment tool, called the Test Of Astronomy STandards (TOAST). Through iterative development, this instrument has a high degree of reliability and validity for instructors and researchers needing information on students’ initial knowledge state at the beginning of a course and can be used, in aggregate, to help measure the impact of course-length duration instructional strategies for courses with learning goals tightly aligned to the consensus goals of our community.

  1. Assessing Mediational Models: Testing and Interval Estimation for Indirect Effects.

    Science.gov (United States)

    Biesanz, Jeremy C; Falk, Carl F; Savalei, Victoria

    2010-08-06

    Theoretical models specifying indirect or mediated effects are common in the social sciences. An indirect effect exists when an independent variable's influence on the dependent variable is mediated through an intervening variable. Classic approaches to assessing such mediational hypotheses ( Baron & Kenny, 1986 ; Sobel, 1982 ) have in recent years been supplemented by computationally intensive methods such as bootstrapping, the distribution of the product methods, and hierarchical Bayesian Markov chain Monte Carlo (MCMC) methods. These different approaches for assessing mediation are illustrated using data from Dunn, Biesanz, Human, and Finn (2007). However, little is known about how these methods perform relative to each other, particularly in more challenging situations, such as with data that are incomplete and/or nonnormal. This article presents an extensive Monte Carlo simulation evaluating a host of approaches for assessing mediation. We examine Type I error rates, power, and coverage. We study normal and nonnormal data as well as complete and incomplete data. In addition, we adapt a method, recently proposed in statistical literature, that does not rely on confidence intervals (CIs) to test the null hypothesis of no indirect effect. The results suggest that the new inferential method-the partial posterior p value-slightly outperforms existing ones in terms of maintaining Type I error rates while maximizing power, especially with incomplete data. Among confidence interval approaches, the bias-corrected accelerated (BC a ) bootstrapping approach often has inflated Type I error rates and inconsistent coverage and is not recommended; In contrast, the bootstrapped percentile confidence interval and the hierarchical Bayesian MCMC method perform best overall, maintaining Type I error rates, exhibiting reasonable power, and producing stable and accurate coverage rates.

  2. Environmental Assessment -- Test Area North pool stabilization project update

    International Nuclear Information System (INIS)

    1997-08-01

    The purpose of this Environmental Assessment (EA) is to update the ''Test Area North Pool Stabilization Project'' EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped from the EA/FONSI issued May 6, 1996. A new drying process was subsequently developed and is analyzed in Section 2.1.2 of this document. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN

  3. Draft environmental assessment -- Test Area North pool stabilization project update

    International Nuclear Information System (INIS)

    1997-06-01

    The purpose of this Environmental Assessment (EA) is to update the ''Test Area North Pool Stabilization Project'' EA (DOE/EA-1050) and finding of no significant impact (FONSI) issued May 6, 1996. This update analyzes the environmental and health impacts of a drying process for the Three Mile Island (TMI) nuclear reactor core debris canisters now stored underwater in a facility on the Idaho National Engineering and Environmental Laboratory (INEEL). A drying process was analyzed in the predecision versions of the EA released in 1995 but that particular process was determined to be ineffective and dropped form the Ea/FONSI issued May 6, 1996. The origin and nature of the TMI core debris and the proposed drying process are described and analyzed in detail in this EA. As did the 1996 EA, this update analyzes the environmental and health impacts of removing various radioactive materials from underwater storage, dewatering these materials, constructing a new interim dry storage facility, and transporting and placing the materials into the new facility. Also, as did the 1996 EA, this EA analyzes the removal, treatment and disposal of water from the pool, and placement of the facility into a safe, standby condition. The entire action would take place within the boundaries of the INEEL. The materials are currently stored underwater in the Test Area North (TAN) building 607 pool, the new interim dry storage facility would be constructed at the Idaho Chemical Processing Plant (ICPP) which is about 25 miles south of TAN

  4. Test Area North Pool Stabilization Project: Environmental assessment

    International Nuclear Information System (INIS)

    1996-05-01

    The Test Area North (TAN) Pool is located within the fenced TAN facility boundaries on the Idaho National Engineering Laboratory (INEL). The TAN pool stores 344 canisters of core debris from the March, 1979, Three Mile Island (TMI) Unit 2 reactor accident; fuel assemblies from Loss-of-Fluid Tests (LOFT); and Government-owned commercial fuel rods and assemblies. The LOFT and government owned commercial fuel rods and assemblies are hereafter referred to collectively as open-quotes commercial fuelsclose quotes except where distinction between the two is important to the analysis. DOE proposes to remove the canisters of TMI core debris and commercial fuels from the TAN Pool and transfer them to the Idaho Chemical Processing Plant (ICPP) for interim dry storage until an alternate storage location other than at the INEL, or a permanent federal spent nuclear fuel (SNF) repository is available. The TAN Pool would be drained and placed in an industrially and radiologically safe condition for refurbishment or eventual decommissioning. This environmental assessment (EA) identifies and evaluates environmental impacts associated with (1) constructing an Interim Storage System (ISS) at ICPP; (2) removing the TMI and commercial fuels from the pool and transporting them to ICPP for placement in an ISS, and (3) draining and stabilizing the TAN Pool. Miscellaneous hardware would be removed and decontaminated or disposed of in the INEL Radioactive Waste Management Complex (RWMC). This EA also describes the environmental consequences of the no action alternative

  5. Assessment of residual life of fast breeder test reactor

    International Nuclear Information System (INIS)

    Srinivasan, G.

    2016-01-01

    The Fast Breeder Test Reactor (FBTR) is a loop type sodium cooled fast reactor and has been in operation since 1985. As a part of regulatory requirement for relicensing, residual life assessment had to be carried out. The systems are made of SS 316, and designed for creep and fatigue. The design life for creep is 100,000 h at 550°C. The design fatigue cycle for operation from shutdown to full power varies from component to component. In general, most of the components are designed for 2000 cycles. The reactor has operated mostly below the design temperatures. It is seen that enough creep-fatigue life is available for the non-replaceable, permanent components. The residual life was found to be governed by the residual ductility of the Grid Plate supporting the core after neutron irradiation. Fast flux measurements were carried out at the grid plate location. Samples were irradiated and tensile tested. Results indicate the allowable dpa for a 10% residual ductility criterion as 4.37. This gave a residual life of ~ 6 Effective Full Power Years for the reactor as of Feb 2012. Measures to reduce the neutron dose on the grid plate are being taken. (author)

  6. Environmental assessment for double tracks test site, Nevada Test Site, Nye County, Nevada

    International Nuclear Information System (INIS)

    1996-04-01

    The U.S. Department of Energy, Nevada Operations Office (DOE/NV), with appropriate approvals from the U.S. Air Force (USAF), proposes to conduct environmental restoration operations at the Double Tracks test site located on the Nellis Air Force Range (NAFR) in Nye County, Nevada. This environmental assessment (EA) evaluates the potential environmental consequences of four alternative actions for conducting the restoration operation and of the no action alternative. The EA also identifies mitigation measures, where appropriate, designed to protect natural and cultural resources and reduce impacts to human health and safety. The environmental restoration operation at the Double Tracks test site would serve two primary objectives. First, the proposed work would evaluate the effectiveness of future restoration operations involving contamination over larger areas. The project would implement remediation technology options and evaluate how these technologies could be applied to the larger areas of contaminated soils on the Nevada Test Site (NTS), the Tonopah Test Range (TTR), and the NAFR. Second, the remediation would provide for the removal of plutonium contamination down to or below a predetermined level which would require cleanup of 1 hectare (ha) (2.5 acres), for the most likely case, or up to 3.0 ha (7.4 acres) of contaminated soil, for the upper bounding case

  7. Virtual reality paced serial assessment test for neuropsychological assessment of a military cohort.

    Science.gov (United States)

    Parsons, Thomas D; Courtney, Christopher; Rizzo, Albert A; Armstrong, Christina; Edwards, Joseph; Reger, Gregory

    2012-01-01

    The assessment and treatment of traumatic brain injury (TBI) has become a difficult challenge for the DoD medical health system. Clinical neuropsychologists are being asked to make statements regarding a soldier's functional skills, ability to return to active duty, and competence in tasks of community living. Given the increasing prevalence of blast injuries to the head, and the fact that many brain injuries may have no external marker of injury, there is need for researching innovative assessment methods in detecting blast-related brain injury. To address these issues, two virtual reality-based Paced Auditory/Visual Serial Addition Tests (PA/VSAT) were developed that involve the participant being immersed in a Virtual Middle Eastern City as serial addition stimuli are presented. This study is an initial validation of the VRPASAT and VRPVSAT as assessments of neurocognitive functioning. When compared to the paper-and-pencil version of the test, as well as the Automated Neuropsychological Assessment Metrics, the VRPASAT and VRPVSAT appear to have enhanced capacity for providing an indication of a participant's performance while immersed in a military relevant simulation.

  8. In-Tank Elutriation Test Report And Independent Assessment

    International Nuclear Information System (INIS)

    Burns, H. H.; Adamson, D. J.; Qureshi, Z. H.; Steeper, T. J.

    2011-01-01

    The Department of Energy (DOE) Office of Environmental Management (EM) funded Technology Development and Deployment (TDD) to solve technical problems associated with waste tank closure for sites such as Hanford Site and Savannah River Site (SRS). One of the tasks supported by this funding at Savannah River National Laboratory (SRNL) and Pacific Northwest Laboratory (PNNL) was In-Tank Elutriation. Elutriation is the process whereby physical separation occurs based on particle size and density. This report satisfies the first phase of Task WP 1 .3.1.1 In-Tank Elutriation, which is to assess the feasibility of this method of separation in waste tanks at Hanford Site and SRS. This report includes an analysis of scoping tests performed in the Engineering Development Laboratory of SRNL, analysis of Hanford's inadvertent elutriation, the viability of separation methods such as elutriation and hydrocyclones and recommendations for a path forward. This report will demonstrate that the retrieval of Hanford salt waste tank S-112 very successfully decreased the tank's inventories of radionuclides. Analyses of samples collected from the tank showed that concentrations of the major radionuclides Cs-136 and Sr-90 were decreased by factors of 250 and 6 and their total curie tank inventories decreased by factors of 60,000 and 2000. The total tank curie loading decreased from 300,000 Ci to 55 Ci. The remaining heel was nearly all innocuous gibbsite, Al(OH) 3 . However, in the process of tank retrieval approximately 85% of the tank gibbsite was also removed. Significant amounts of money and processing time could be saved if more gibbsite could be left in tanks while still removing nearly all of the radionuclides. There were factors which helped to make the elutriation of Tank S-112 successful which would not necessarily be present in all salt tanks. 1. The gibbsite particles in the tank were surprisingly large, as much as 200 o)m. The gibbsite crystals had probably grown in size over

  9. Evaluation of project based learning sufficiency of teacher candidates

    Directory of Open Access Journals (Sweden)

    Vasfi Tugun

    2012-01-01

    Full Text Available The aim of that research, it is the project based learning process suffuciency of teacher candidates who developedmultimedia by working in online and blended groups. Importance of research Being able to guide to studies that is going tobe done about assessment of multimedia projection for project based educational application to teachers and teachercandidates and It has been thought as an advisor source about being arranged new educational environment for the futureto teacher and teacher candidates for project based educational application and multimedia projection. Research is anexperimental study and has been shaped according to pre-test and last-test research model with the two groups. This groupsare online group and blended group. Discussion of research In the result of the study, in the process of project basedlearning, it is determined that the success level in multimedia development of teacher candidates who work in blendedlearning model is higher than the success level of teacher candidates who work in online learning model.

  10. Assessment of Dengue Fever Severity Through Liver Function Tests

    International Nuclear Information System (INIS)

    Ahmed, A.; Alvi, A. H.; Nawaz, A. A.; Butt, A.; Hanif, A.

    2014-01-01

    Objective: To assess the utility of liver function tests (LFTs) for early recognition and prediction of severity of Dengue fever in hospitalized patients. Study Design: An analytical study. Place and Duration of Study: Services Institute of Medical Science and Fatima Memorial Hospital, Lahore, from September - December 2010. Methodology: Admitted cases of Dengue fever were divided into 3 groups; mild, moderate and severe increases in aminotransferases. Elevation in LFTs was co-related with good or bad outcome i.e. (survival or complication free stay) or (death or complications). Results were analyzed in SPSS version 18. Results: Out of the 353 patients with mean age of 37.12 +- 15.45 years, 245 (69.4%) were males and 108 (30.6%) were females. Seventy five patients (21.2%) had mild elevation of aminotransferases (2 fold increases), 265 patients (75.1%) had moderate increases (3 to 4 fold) and 13 (3.7%) had severe (> 4 fold increase). ALT was statistically higher in patients with septicemia, hepatic and renal failure (p-value 0.05). AST was higher in almost all complications. Prolonged hospital stay was associated with raised LFTs and greater complications and mortality. AST was found to be twice as much raised as ALT. Conclusion: AST and ALT were statistically higher in patients with worse outcome thus can lead to early recognition of high risk cases. (author)

  11. Neutron activation analysis method - international ring test for proficiency assessment

    International Nuclear Information System (INIS)

    Barbos, D.; Bucsa, A. F.

    2016-01-01

    The main objective of this test is to assess the quality control of analytical procedures for soils and plants which is of utmost importance to produce reliable and reproducible analytical data. For this purpose first, second, and third line quality control measures are taken in analytical laboratories. For first line control certified reference materials (CRM's) are preferred. However, the number and matrix variation in CRM's for environmental analytical research is still very limited. For second line control internal reference samples are often used, but again here the values for many element and parameter concentrations are questionable since almost no check versus CRM's is possible. For third line control participation in laboratory-evaluating exchange programs is recommended. This article contains the results achieved by our neutron activation analysis laboratory after irradiation experiment of soil and vegetation samples in TRIGA Reactor. All the samples were irradiated in the same location of the reactor in roughly similar conditions. (authors)

  12. Advanced Test Reactor probabilistic risk assessment methodology and results summary

    International Nuclear Information System (INIS)

    Eide, S.A.; Atkinson, S.A.; Thatcher, T.A.

    1992-01-01

    The Advanced Test Reactor (ATR) probabilistic risk assessment (PRA) Level 1 report documents a comprehensive and state-of-the-art study to establish and reduce the risk associated with operation of the ATR, expressed as a mean frequency of fuel damage. The ATR Level 1 PRA effort is unique and outstanding because of its consistent and state-of-the-art treatment of all facets of the risk study, its comprehensive and cost-effective risk reduction effort while the risk baseline was being established, and its thorough and comprehensive documentation. The PRA includes many improvements to the state-of-the-art, including the following: establishment of a comprehensive generic data base for component failures, treatment of initiating event frequencies given significant plant improvements in recent years, performance of efficient identification and screening of fire and flood events using code-assisted vital area analysis, identification and treatment of significant seismic-fire-flood-wind interactions, and modeling of large loss-of-coolant accidents (LOCAs) and experiment loop ruptures leading to direct damage of the ATR core. 18 refs

  13. Chromium 51-ethylenediaminetetraacetate test: a useful test in the assessment of inflammatory bowel disease

    International Nuclear Information System (INIS)

    O'Morain, C.A.; Abelow, A.C.; Chervu, L.R.; Fleischner, G.M.; Das, K.M.

    1986-01-01

    We evaluated the usefulness of urinary excretion values in assessing mucosal damage in inflammatory bowel disease after administration of chromium 51-labeled EDTA either orally or rectally. In the oral study, 19 controls, 18 patients with Crohn's disease, and 13 patients with ulcerative colitis were given 100 microCi 51 Cr-EDTA by mouth. The amount of 51 Cr-EDTA in a 24-hour urine collection was expressed as a percentage of the ingested dose. The patients with Crohn's disease of the small bowel excreted 6.3% +/- 4.3%, which was significantly (P less than 0.001) higher than the percentage in patients with ulcerative colitis (1.7% +/- 1.1%) and controls (1.4% +/- 0.6%). In the enema study, 19 patients with ulcerative colitis, two with Crohn's disease, two with radiation colitis, and four controls (spastic colitis, lactose intolerance) were given 100 microCi 51 Cr-EDTA by retention enema. The patients with active colonic inflammation excreted 8.4% +/- 3.9% of the dose given by enema, which was significantly (P less than 0.01) higher than in other controls (1.9% +/- 0.91%) or patients with inactive colitis (2.2% +/- 1.9%). The 51 Cr-EDTA excretion test is a safe, inexpensive test useful in evaluating patients with inflammatory bowel disease. It can be given orally to screen patients with abdominal complaints who are suspected of having Crohn's disease involving the small intestine, and when given by enema it provides additional objective assessment of idiopathic ulcerative colitis or proctitis

  14. Chromium 51-ethylenediaminetetraacetate test: a useful test in the assessment of inflammatory bowel disease

    Energy Technology Data Exchange (ETDEWEB)

    O' Morain, C.A.; Abelow, A.C.; Chervu, L.R.; Fleischner, G.M.; Das, K.M.

    1986-11-01

    We evaluated the usefulness of urinary excretion values in assessing mucosal damage in inflammatory bowel disease after administration of chromium 51-labeled EDTA either orally or rectally. In the oral study, 19 controls, 18 patients with Crohn's disease, and 13 patients with ulcerative colitis were given 100 microCi /sup 51/Cr-EDTA by mouth. The amount of /sup 51/Cr-EDTA in a 24-hour urine collection was expressed as a percentage of the ingested dose. The patients with Crohn's disease of the small bowel excreted 6.3% +/- 4.3%, which was significantly (P less than 0.001) higher than the percentage in patients with ulcerative colitis (1.7% +/- 1.1%) and controls (1.4% +/- 0.6%). In the enema study, 19 patients with ulcerative colitis, two with Crohn's disease, two with radiation colitis, and four controls (spastic colitis, lactose intolerance) were given 100 microCi /sup 51/Cr-EDTA by retention enema. The patients with active colonic inflammation excreted 8.4% +/- 3.9% of the dose given by enema, which was significantly (P less than 0.01) higher than in other controls (1.9% +/- 0.91%) or patients with inactive colitis (2.2% +/- 1.9%). The /sup 51/Cr-EDTA excretion test is a safe, inexpensive test useful in evaluating patients with inflammatory bowel disease. It can be given orally to screen patients with abdominal complaints who are suspected of having Crohn's disease involving the small intestine, and when given by enema it provides additional objective assessment of idiopathic ulcerative colitis or proctitis.

  15. Comparison of Classical Test Theory and Item Response Theory in Individual Change Assessment

    NARCIS (Netherlands)

    Jabrayilov, Ruslan; Emons, Wilco H. M.; Sijtsma, Klaas

    2016-01-01

    Clinical psychologists are advised to assess clinical and statistical significance when assessing change in individual patients. Individual change assessment can be conducted using either the methodologies of classical test theory (CTT) or item response theory (IRT). Researchers have been optimistic

  16. Assessment of homogeneity of candidate reference material at the nanogram level and investigation on representativeness of single particle analysis using electron probe X ray microanalysis

    International Nuclear Information System (INIS)

    Ro, Chul-Un; Hoornaerta, S.; Griekena, R. van

    2002-01-01

    Particulate samples of a candidate reference material are evaluated on their homogeneity from bottle to bottle using electron probe X ray microanalysis technique. The evaluation on the homogeneity is done by the utilization of the Kolmogorov-Smirnov statistics to the processing of the quantitative electron probe X ray microanalysis data. Due to a limitation, existing even in computer controlled electron probe X ray microanalysis, in terms of analysis time and expenses, the number of particles analyzed is much smaller compared to that in the sample. Therefore, it is investigated whether this technique provides representative analysis results for the characteristics of the sample, even though a very small portion of the sample is really analyzed. Furthermore, the required number of particles for the analysis, to insure a certain level of reproducibility, e.g. 5% relative standard deviation, is determined by the application of the Ingamells sampling theory. (author)

  17. Testing an Automated Accuracy Assessment Method on Bibliographic Data

    Directory of Open Access Journals (Sweden)

    Marlies Olensky

    2014-12-01

    Full Text Available This study investigates automated data accuracy assessment as described in data quality literature for its suitability to assess bibliographic data. The data samples comprise the publications of two Nobel Prize winners in the field of Chemistry for a 10-year-publication period retrieved from the two bibliometric data sources, Web of Science and Scopus. The bibliographic records are assessed against the original publication (gold standard and an automatic assessment method is compared to a manual one. The results show that the manual assessment method reflects truer accuracy scores. The automated assessment method would need to be extended by additional rules that reflect specific characteristics of bibliographic data. Both data sources had higher accuracy scores per field than accumulated per record. This study contributes to the research on finding a standardized assessment method of bibliographic data accuracy as well as defining the impact of data accuracy on the citation matching process.

  18. Pruebas de acceso a la formación sanitaria especializada para médicos y otros profesionales sanitarios en España: examinando el examen y los examinados Access tests to specialized health training for doctors and other healthcare professionals in Spain: examining the exam and the examined candidates

    Directory of Open Access Journals (Sweden)

    Albert Bonillo

    2012-06-01

    Full Text Available Objetivos: Estudiar las pruebas de acceso a la Formación Sanitaria Especializada de las convocatorias 2005 y 2006. Se pretende evaluar la calidad de los exámenes y explorar las variables de los aspirantes que permiten predecir la puntuación final. Métodos: El Ministerio de Sanidad y Consumo proporcionó las respuestas de los 23.136 aspirantes de ambas convocatorias, así como variables demográficas y el valor baremado de su expediente académico. Resultados: Se realiza un análisis de ítems a partir de las respuestas de los aspirantes para así evaluar la fiabilidad de las pruebas. Además, se calculan modelos de regresión lineal para estudiar qué variables permiten predecir la puntuación final de un aspirante. Conclusiones: Las pruebas de acceso a la Formación Sanitaria Especializada tienen una excelente calidad psicométrica. Serían optimizables reduciendo el número de alternativas y eliminando algunos ítems más a posteriori. Por último, los alumnos españoles son los que mejor nota media ajustada logran.Objectives: This study examines the accessing tests to Specialised Health Training for 2005 and 2006 calls. It aims to assess the quality of exams and explore candidates' variables that allow predicting the final score. Methods: The Ministry of Health provided the 23,136 candidates' answer from both calls, plus demographic variables and the normalised value of their student record. Results: Item's analysis is made from candidates' answers for evaluating the test reliability. In addition, it's been calculated linear regression models for studying which variables allow predicting a candidate's final score. Conclusions: the accessing tests to Specialised Health Training have excellent psychometric quality. It would be improved by reducing the number of choices and eliminating some items more afterwards. Finally, Spanish students are the ones who achieved best adjusted mean score.

  19. Assessment of the Use of the Nelson Denny Reading Test.

    Science.gov (United States)

    Perkins, Dorothy

    1984-01-01

    The Nelson Denny Reading Test (NDRT) is probably the most widely used test of reading comprehension at the college level in the nation. However, reviews of the test, as well as recent reports of its failure to adequately measure gain or lack of gain of college students enrolled in reading improvement courses, do not support the popularity it has…

  20. Construction of Valid and Reliable Test for Assessment of Students

    Science.gov (United States)

    Osadebe, P. U.

    2015-01-01

    The study was carried out to construct a valid and reliable test in Economics for secondary school students. Two research questions were drawn to guide the establishment of validity and reliability for the Economics Achievement Test (EAT). It is a multiple choice objective test of five options with 100 items. A sample of 1000 students was randomly…

  1. Benchmark Tests for Stirling Convertor Heater Head Life Assessment Conducted

    Science.gov (United States)

    Krause, David L.; Halford, Gary R.; Bowman, Randy R.

    2004-01-01

    A new in-house test capability has been developed at the NASA Glenn Research Center, where a critical component of the Stirling Radioisotope Generator (SRG) is undergoing extensive testing to aid the development of analytical life prediction methodology and to experimentally aid in verification of the flight-design component's life. The new facility includes two test rigs that are performing creep testing of the SRG heater head pressure vessel test articles at design temperature and with wall stresses ranging from operating level to seven times that (see the following photograph).

  2. Gene Expression Profiling of Human Vaginal Cells In Vitro Discriminates Compounds with Pro-Inflammatory and Mucosa-Altering Properties: Novel Biomarkers for Preclinical Testing of HIV Microbicide Candidates.

    Directory of Open Access Journals (Sweden)

    Irina A Zalenskaya

    Full Text Available Inflammation and immune activation of the cervicovaginal mucosa are considered factors that increase susceptibility to HIV infection. Therefore, it is essential to screen candidate anti-HIV microbicides for potential mucosal immunomodulatory/inflammatory effects prior to further clinical development. The goal of this study was to develop an in vitro method for preclinical evaluation of the inflammatory potential of new candidate microbicides using a microarray gene expression profiling strategy.To this end, we compared transcriptomes of human vaginal cells (Vk2/E6E7 treated with well-characterized pro-inflammatory (PIC and non-inflammatory (NIC compounds. PICs included compounds with different mechanisms of action. Gene expression was analyzed using Affymetrix U133 Plus 2 arrays. Data processing was performed using GeneSpring 11.5 (Agilent Technologies, Santa Clara, CA.Microarraray comparative analysis allowed us to generate a panel of 20 genes that were consistently deregulated by PICs compared to NICs, thus distinguishing between these two groups. Functional analysis mapped 14 of these genes to immune and inflammatory responses. This was confirmed by the fact that PICs induced NFkB pathway activation in Vk2 cells. By testing microbicide candidates previously characterized in clinical trials we demonstrated that the selected PIC-associated genes properly identified compounds with mucosa-altering effects. The discriminatory power of these genes was further demonstrated after culturing vaginal cells with vaginal bacteria. Prevotella bivia, prevalent bacteria in the disturbed microbiota of bacterial vaginosis, induced strong upregulation of seven selected PIC-associated genes, while a commensal Lactobacillus gasseri associated to vaginal health did not cause any changes.In vitro evaluation of the immunoinflammatory potential of microbicides using the PIC-associated genes defined in this study could help in the initial screening of candidates prior

  3. Lay perceptions of predictive testing for diabetes based on DNA test results versus family history assessment: a focus group study.

    Science.gov (United States)

    Wijdenes-Pijl, Miranda; Dondorp, Wybo J; Timmermans, Danielle Rm; Cornel, Martina C; Henneman, Lidewij

    2011-07-05

    This study assessed lay perceptions of issues related to predictive genetic testing for multifactorial diseases. These perceived issues may differ from the "classic" issues, e.g. autonomy, discrimination, and psychological harm that are considered important in predictive testing for monogenic disorders. In this study, type 2 diabetes was used as an example, and perceptions with regard to predictive testing based on DNA test results and family history assessment were compared. Eight focus group interviews were held with 45 individuals aged 35-70 years with (n = 3) and without (n = 1) a family history of diabetes, mixed groups of these two (n = 2), and diabetes patients (n = 2). All interviews were transcribed and analysed using Atlas-ti. Most participants believed in the ability of a predictive test to identify people at risk for diabetes and to motivate preventive behaviour. Different reasons underlying motivation were considered when comparing DNA test results and a family history risk assessment. A perceived drawback of DNA testing was that diabetes was considered not severe enough for this type of risk assessment. In addition, diabetes family history assessment was not considered useful by some participants, since there are also other risk factors involved, not everyone has a diabetes family history or knows their family history, and it might have a negative influence on family relations. Respect for autonomy of individuals was emphasized more with regard to DNA testing than family history assessment. Other issues such as psychological harm, discrimination, and privacy were only briefly mentioned for both tests. The results suggest that most participants believe a predictive genetic test could be used in the prevention of multifactorial disorders, such as diabetes, but indicate points to consider before both these tests are applied. These considerations differ with regard to the method of assessment (DNA test or obtaining family history) and also differ from

  4. Lay perceptions of predictive testing for diabetes based on DNA test results versus family history assessment: a focus group study

    Directory of Open Access Journals (Sweden)

    Cornel Martina C

    2011-07-01

    Full Text Available Abstract Background This study assessed lay perceptions of issues related to predictive genetic testing for multifactorial diseases. These perceived issues may differ from the "classic" issues, e.g. autonomy, discrimination, and psychological harm that are considered important in predictive testing for monogenic disorders. In this study, type 2 diabetes was used as an example, and perceptions with regard to predictive testing based on DNA test results and family history assessment were compared. Methods Eight focus group interviews were held with 45 individuals aged 35-70 years with (n = 3 and without (n = 1 a family history of diabetes, mixed groups of these two (n = 2, and diabetes patients (n = 2. All interviews were transcribed and analysed using Atlas-ti. Results Most participants believed in the ability of a predictive test to identify people at risk for diabetes and to motivate preventive behaviour. Different reasons underlying motivation were considered when comparing DNA test results and a family history risk assessment. A perceived drawback of DNA testing was that diabetes was considered not severe enough for this type of risk assessment. In addition, diabetes family history assessment was not considered useful by some participants, since there are also other risk factors involved, not everyone has a diabetes family history or knows their family history, and it might have a negative influence on family relations. Respect for autonomy of individuals was emphasized more with regard to DNA testing than family history assessment. Other issues such as psychological harm, discrimination, and privacy were only briefly mentioned for both tests. Conclusion The results suggest that most participants believe a predictive genetic test could be used in the prevention of multifactorial disorders, such as diabetes, but indicate points to consider before both these tests are applied. These considerations differ with regard to the method of assessment

  5. Acceptance Test Data for Candidate AGR-5/6/7 TRISO Particle Batches BWXT Coater Batches 93165 93172 Defective IPyC Fraction and Pyrocarbon Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, Grant W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hunn, John D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skitt, Darren J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dyer, John A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Schumacher, Austin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-03-01

    Coated particle fuel batches J52O-16-93165, 93166, 93168, 93169, 93170, and 93172 were produced by Babcock and Wilcox Technologies (BWXT) for possible selection as fuel for the Advanced Gas Reactor Fuel Development and Qualification (AGR) Program’s AGR-5/6/7 irradiation test in the Idaho National Laboratory (INL) Advanced Test Reactor (ATR). Some of these batches may alternately be used as demonstration coated particle fuel for other experiments. Each batch was coated in a 150-mm-diameter production-scale fluidized-bed chemical vapor deposition (CVD) furnace. Tristructural isotropic (TRISO) coatings were deposited on 425-μm-nominal-diameter spherical kernels from BWXT lot J52R-16-69317 containing a mixture of 15.5%-enriched uranium carbide and uranium oxide (UCO). The TRISO coatings consisted of four consecutive CVD layers: a ~50% dense carbon buffer layer with 100-μm-nominal thickness, a dense inner pyrolytic carbon (IPyC) layer with 40-μm-nominal thickness, a silicon carbide (SiC) layer with 35-μm-nominal thickness, and a dense outer pyrolytic carbon (OPyC) layer with 40-μmnominal thickness. The TRISO-coated particle batches were sieved to upgrade the particles by removing over-sized and under-sized material, and the upgraded batches were designated by appending the letter A to the end of the batch number (e.g., 93165A).

  6. Using a Bedside Video-assisted Test Tube Test to Assess Stoma Viability: A Report of 4 Cases.

    Science.gov (United States)

    Ahmad, Sarwat; Turner, Keli; Shah, Paulesh; Diaz, Jose

    2016-07-01

    Mucosal discoloration of an intestinal stoma may indicate self-limited venous congestion or necrosis necessitating operative revision. A common bedside technique to assess stoma viability is the "test tube test". A clear tube is inserted into the stoma and a hand-held light is used to assess the color of the stoma. A technique (video-assisted test tube test [VATTT]) developed by the authors utilizes a standard video bronchoscope inserted into a clear plastic blood collection tube to visually inspect and assess the mucosa. This technique was evaluated in 4 patients (age range 49-72 years, all critically ill) with a discolored stoma after emergency surgery. In each case, physical exam revealed ischemic mucosa at the surface either immediately after surgery or after worsening hypotension weeks later. Serial test tube test assessments were ambiguous when trying to assess deeper mucosa. The VATTT assessment showed viable pink mucosa beneath the surface and until the fascia was revealed in 3 patients. One (1) patient had mucosal ischemia down to the fascia, which prompted operative revision of the stoma. The new stoma was assessed with a VATTT and was viable for the entire length of the stoma. VATTT provided an enhanced, magnified, and clearer way to visually assess stoma viability in the postoperative period that can be performed at the bedside with no adverse events. It may prevent unnecessary relaparotomy or enable earlier diagnosis of deep ostomy necrosis. Validity and reliability studies are warranted.

  7. Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice

    Directory of Open Access Journals (Sweden)

    Qiu Chunhui

    2012-08-01

    Full Text Available Abstract Background Thyroid hormones (TH modulate growth, development and differentiation and metabolic processes by interacting with thyroid hormone receptors (THRs. The purpose of this study was to identify a novel thyroid hormone receptor beta encoding gene of Schistosoma japonicum (SjTHRβ and to investigate its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice. Methods The full-length cDNA sequence of SjTHRβ, its gene organization, and its transcript levels were characterized, and the phylogenetic relationship between THR, RAR and RXR from other organisms were analysis, the ability of this protein binding to a conserved DNA core motif, and its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice were evaluated. Results The SjTHRβ cDNA was cloned, verified by 5’ and 3’ Rapid Amplification of cDNA Ends and shown to be polyadenylated at the 3’end, suggesting the transcript is full-length. SjTHRβ is homologous to THRs from other species and has a predicted conservative DNA binding domain and ligand binding domain that normally characterizes these receptors. A comparative quantitative PCR analysis showed that SjTHRβ was the highest expressed in 21d worms and the lowest in 7 d and 13 d schistosomula. The cDNA corresponding to DNA binding domain (SjTHRβ-DBD and ligand binding domain (SjTHRβ-LBD were cloned and subsequently expressed in E coli. The expressed proteins were used to immunize mice and generate specific serum against recombinant SjTHRβ (rSjTHRβ. Western blotting revealed that anti-rSjTHRβ-LBD serum recognized two protein bands in extracts from 21 d worm with molecular sizes of approximately 95 kDa and 72 kDa. Electrophoretic mobility shift assay (EMSA analysis showed that rSjTHRβ-DBD could bind to a conserved DNA core motif. Immunization of BALB/c mice with rSjTHRβ-LBD could induce partial protective efficacy(27.52% worm reduction and 29.50% liver eggs

  8. Assessment of the quality of test results from selected civil engineering material testing laboratories in Tanzania

    CSIR Research Space (South Africa)

    Mbawala, SJ

    2017-12-01

    Full Text Available Civil and geotechnical engineering material testing laboratories are expected to produce accurate and reliable test results. However, the ability of laboratories to produce accurate and reliable test results depends on many factors, among others...

  9. Assessment of chimeric mice with humanized livers in new drug development: generation of pharmacokinetics, metabolism and toxicity data for selecting the final candidate compound.

    Science.gov (United States)

    Kamimura, Hidetaka; Ito, Satoshi

    2016-01-01

    1. Chimeric mice with humanized livers are expected to be a novel tool for new drug development. This review discusses four applications where these animals can be used efficiently to collect supportive data for selecting the best compound in the final stage of drug discovery. 2. The first application is selection of the final compound based on estimated pharmacokinetic parameters in humans. Since chimeric mouse livers are highly repopulated with human hepatocytes, hepatic clearance values in vivo could be used preferentially to estimate pharmacokinetic profiles for humans. 3. The second is prediction of human-specific or disproportionate metabolites. Chimeric mice reproduce human-specific metabolites of drugs under development to conform to ICH guidance M3(R2), except for compounds that were extensively eliminated by co-existing mouse hepatocytes. 4. The third is identifying metabolites with distinct pharmacokinetic profiles in humans. Slow metabolite elimination specifically in humans increases its exposure level, but if its elimination is faster in laboratory animals, the animal exposure level might not satisfy ICH guidance M3(R2). 5. Finally, two examples of reproducing acute liver toxicity in chimeric mice are introduced. Integrated pharmacokinetics, metabolism and toxicity information are expected to assist pharmaceutical scientists in selecting the best candidate compound in new drug development.

  10. Beam path toxicity in candidate organs-at-risk: Assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy

    International Nuclear Information System (INIS)

    Kocak-Uzel, Esengul; Gunn, G. Brandon; Colen, Rivka R.; Kantor, Micheal E.; Mohamed, Abdallah S.R.; Schoultz-Henley, Sara; Mavroidis, Paniyotis; Frank, Steven J.; Garden, Adam S.; Beadle, Beth M.; Morrison, William H.; Phan, Jack; Rosenthal, David I.; Fuller, Clifton D.

    2014-01-01

    Background: To investigate potential dose–response relationship between radiation-associated nausea and vomiting (RANV) reported during radiotherapy and candidate nausea/vomiting-associated regions of interest (CNV-ROIs) in head and neck (HNC) squamous cell carcinomas. Methods and material: A total of 130 patients treated with IMRT with squamous cell carcinomas of head and neck were evaluated. For each patient, CNV-ROIs were segmented manually on planning CT images. Clinical on-treatment RANV data were reconstructed by a review of the records for all patients. Dosimetric data parameters were recorded from dose–volume histograms. Nausea and vomiting reports were concatenated as a single binary “Any N/V” variable, and as a “CTC-V2+” variable. Results: The mean dose to CNV-ROIs was higher for patients experiencing RANV events. For patients receiving IMRT alone, a dose–response effect was observed with varying degrees of magnitude, at a statistically significant level for the area postrema, brainstem, dorsal vagal complex, medulla oblongata, solitary nucleus, oropharyngeal mucosa and whole brain CNV-ROIs. Conclusion: RANV is a common therapy-related morbidity facing patients receiving HNC radiotherapy, and, for those receiving radiotherapy-alone, is associated with modifiable dose to specific CNS structures

  11. [The methodological assessment and qualitative evaluation of psychometric performance tests based on the example of modern tests that assess reading and spelling skills].

    Science.gov (United States)

    Galuschka, Katharina; Rothe, Josefine; Schulte-Körne, Gerd

    2015-09-01

    This article looks at a means of objectively evaluating the quality of psychometric tests. This approach enables users to evaluate psychometric tests based on their methodological characteristics, in order to decide which instrument should be used. Reading and spelling assessment tools serve as examples. The paper also provides a review of German psychometric tests for the assessment of reading and spelling skills. This method facilitates the identification of psychometric tests.of high methodological quality which can be used for the assessment of reading and spelling skills. Reading performance should ideally be assessed with the following instruments: ELFE 1-6, LGVT 6-12, LESEN 6-7, LESEN 8-9, or WLLP-R. The tests to be used for the evaluation of spelling skills are DERET 1-2+, DERET 3-4+, WRT 1+, WRT 2+, WRT 3+, WRT 4+ or HSP 1-10.

  12. The conditioned place preference test for assessing welfare consequences and potential refinements in a mouse bladder cancer model.

    Directory of Open Access Journals (Sweden)

    John V Roughan

    Full Text Available Most pre-clinical analgesic efficacy assays still involve nociceptive testing in rodents. This is despite concerns as to the relevance of these tests for evaluating the pain-preventative properties of drugs. More appropriate methods would target pain rather than nociception, but these are currently not available, so it remains unknown whether animal pain equates to the negatively affective and subjective/emotional state it causes in humans. Mouse cancer models are common despite the likelihood of substantial pain. We used Conditioned Place Preference (CPP testing, assessments of thermal hyperalgesia and behaviour to determine the likelihood that MBT-2 bladder cancer impacts negatively on mouse welfare, such as by causing pain. There was no CPP to saline, but morphine preference in tumour bearing mice exceeded that seen in tumour-free controls. This occurred up to 10 days before the study end-point alongside reduced body weight, development of hyperalgesia and behaviour changes. These effects indicated mice experienced a negative welfare state caused by malaise (if not pain before euthanasia. Due to the complexity of the assessments needed to demonstrate this, it is unlikely that this approach could be used for routine welfare assessment on a study-by-study basis. However, our results show mice in sufficiently similar studies are likely to benefit from more intensive severity assessment and re-evaluation of end-points with a view to implementing appropriate refinements. In this particular case, a refinement would have been to have euthanased mice at least 7 days earlier or possibly by provision of end-stage pain relief. CPP testing was found to be a helpful method to investigate the responses of mice to analgesics, possibly on a subjective level. These findings and those of other recent studies show it could be a valuable method of screening candidate analgesics for efficacy against cancer pain and possibly other pain or disease models.

  13. Deep Learning Questions Can Help Selection of High Ability Candidates for Universities

    Science.gov (United States)

    Mellanby, Jane; Cortina-Borja, Mario; Stein, John

    2009-01-01

    Selection of students for places at universities mainly depends on GCSE grades and predictions of A-level grades, both of which tend to favour applicants from independent schools. We have therefore developed a new type of test that would measure candidates' "deep learning" approach since this assesses the motivation and creative thinking…

  14. Assessment of Minimal HE (with emphasis on computerized psychometric tests)

    Science.gov (United States)

    Kappus, Matthew R; Bajaj, Jasmohan S

    2012-01-01

    Synopsis Minimal hepatic encephalopathy (MHE) is associated with a high risk of development of overt hepatic encephalopathy, impaired quality of life and driving accidents. The detection of MHE requires specialized testing since it cannot by definition, be diagnosed on standard clinical examination. Psychometric (paper-pencil or computerized or a combination) and neuro-physiological techniques are often used to test for MHE. Paper-pencil psychometric batteries like the Psychometric Hepatic Encephalopathy Score (PHES) have been validated in several countries but do not have US normative values. Computerized tests such as the inhibitory control test (ICT), cognitive drug research system and Scan test have proven useful to diagnose MHE and predict outcomes. The specificity and sensitivity of these tests are similar to the recommended gold standards. Neuro-physiological tests such as the EEG and its interpretations, evoked potentials and Critical Flicker Frequency (CFF) also provide useful information. The diagnosis of MHE is an important issue for clinicians and patients alike and the testing strategies depend on the normative data available, patient comfort and local expertise. PMID:22321464

  15. Assessing Mathematical Competencies: An Analysis of Swedish National Mathematics Tests

    Science.gov (United States)

    Boesen, Jesper; Lithner, Johan; Palm, Torulf

    2018-01-01

    Internationally, education reform has been directed towards describing educational goals that go beyond topic and content descriptions. The idea of mathematical competencies describes such goals. National tests have been seen as one way of communicating these goals and influence teaching. The present study analyses Swedish national tests in…

  16. Creating an Online Assessment Test for Heritage Learners of Russian

    Science.gov (United States)

    Titus, Julia

    2012-01-01

    This paper examines the differences between second-language learners and heritage learners of Russian in terms of their linguistic performance, a finding supported by current research (Andrews, 2001; Kagan & Dillon, 2001/2003), examines the implications of these differences for the creation of testing tools, and offers a sample of a test designed…

  17. Assessment of the Nevada Test Site as a Site for Distributed Resource Testing and Project Plan: March 2002

    Energy Technology Data Exchange (ETDEWEB)

    Horgan, S.; Iannucci, J.; Whitaker, C.; Cibulka, L.; Erdman, W.

    2002-05-01

    The objective of this project was to evaluate the Nevada Test Site (NTS) as a location for performing dedicated, in-depth testing of distributed resources (DR) integrated with the electric distribution system. In this large scale testing, it is desired to operate multiple DRs and loads in an actual operating environment, in a series of controlled tests to concentrate on issues of interest to the DR community. This report includes an inventory of existing facilities at NTS, an assessment of site attributes in relation to DR testing requirements, and an evaluation of the feasibility and cost of upgrades to the site that would make it a fully qualified DR testing facility.

  18. Assessing cultural validity in standardized tests in stem education

    Science.gov (United States)

    Gassant, Lunes

    This quantitative ex post facto study examined how race and gender, as elements of culture, influence the development of common misconceptions among STEM students. Primary data came from a standardized test: the Digital Logic Concept Inventory (DLCI) developed by Drs. Geoffrey L. Herman, Michael C. Louis, and Craig Zilles from the University of Illinois at Urbana-Champaign. The sample consisted of a cohort of 82 STEM students recruited from three universities in Northern Louisiana. Microsoft Excel and the Statistical Package for the Social Sciences (SPSS) were used for data computation. Two key concepts, several sub concepts, and 19 misconceptions were tested through 11 items in the DLCI. Statistical analyses based on both the Classical Test Theory (Spearman, 1904) and the Item Response Theory (Lord, 1952) yielded similar results: some misconceptions in the DLCI can reliably be predicted by the Race or the Gender of the test taker. The research is significant because it has shown that some misconceptions in a STEM discipline attracted students with similar ethnic backgrounds differently; thus, leading to the existence of some cultural bias in the standardized test. Therefore the study encourages further research in cultural validity in standardized tests. With culturally valid tests, it will be possible to increase the effectiveness of targeted teaching and learning strategies for STEM students from diverse ethnic backgrounds. To some extent, this dissertation has contributed to understanding, better, the gap between high enrollment rates and low graduation rates among African American students and also among other minority students in STEM disciplines.

  19. Segmental analysis of cochlea on three-dimensional MR imaging and high-resolution CT. Application to pre-operative assessment of cochlear implant candidates

    International Nuclear Information System (INIS)

    Akiba, Hidenari; Himi, Tetsuo; Hareyama, Masato

    2002-01-01

    High-resolution computed tomography (HRCT) and magnetic resonance imaging (MRI) have recently become standard pre-operative examinations for cochlear implant candidates. HRCT can demonstrate ossification and narrowing of the cochlea, but subtle calcification or soft tissue obstruction may not be detected by this method alone, and so conventional T2 weighted image (T2WI) on MRI has been recommended to disclose them. In this study, segmental analyses of the cochlea were made on three-dimensional MRI (3DMRI) and HRCT in order to predict cochlear implant difficulties. The study involved 59 consecutive patients with bilateral profound sensorineural hearing loss who underwent MRI and HRCT from November 1992 to February 1998. Etiologies of deafness were meningogenic labyrinthitis (n=9), tympanogenic labyrinthitis (n=12), and others (n=38). Pulse sequence of heavy T2WI was steady state free precession and 3DMRI was reconstructed by maximum intensity projection method. HRCT was reconstructed by bone algorithm focusing on the temporal bone. For alternative segmental analysis, cochleas were anatomically divided into five parts and each of them was classified by three ranks of score depending on 3DMRI or HRCT findings. There was a close correlation by ranks between the total score of the five parts on 3DMRI and HRCT (rs=0.86, P<0.001), and a statistically significant difference was identified between causes of deafness in the total score on 3DMRI or HRCT (P<0.001, respectively). There was a significant difference in the score among the five parts on each examination (P<0.001, respectively), and abnormal findings were more frequent in the inferior horizontal part (IHP) of the basal turn. Of the 35 patients who underwent cochlear implantation, no one had ossification in the IHP on HRCT and only one patient had an obstacle to implantation. When no signal void in the IHP on 3DMRI and no ossification in the IHP on HRCT were assumed to be the criteria for candidacy for cochlear

  20. Testing-Context Analysis: Assessment Is Just Another Part of Language Curriculum Development

    Science.gov (United States)

    Brown, James Dean

    2008-01-01

    In keeping with the theme of the International Language Testing Association/Language Testing Research Colloquium Conference in 2008, "Focusing on the Core: Justifying the Use of Language Assessments to Stakeholders," I define "stakeholder-friendly tests," "defensible testing," and "testing-context analysis."…

  1. A randomized trial assessing the safety and immunogenicity of AS01 and AS02 adjuvanted RTS,S malaria vaccine candidates in children in Gabon.

    Directory of Open Access Journals (Sweden)

    Bertrand Lell

    2009-10-01

    Full Text Available The malaria vaccine candidate antigen RTS,S includes parts of the pre-erythrocytic stage circumsporozoite protein fused to the Hepatitis B surface antigen. Two Adjuvant Systems are in development for this vaccine, an oil-in water emulsion--based formulation (AS02 and a formulation based on liposomes (AS01.In this Phase II, double-blind study (NCT00307021, 180 healthy Gabonese children aged 18 months to 4 years were randomized to receive either RTS,S/AS01(E or RTS,S/AS02(D, on a 0-1-2 month vaccination schedule. The children were followed-up daily for six days after each vaccination and monthly for 14 months. Blood samples were collected at 4 time-points. Both vaccines were well tolerated. Safety parameters were distributed similarly between the two groups. Both vaccines elicited a strong specific immune response after Doses 2 and 3 with a ratio of anti-CS GMT titers (AS02(D/AS01(E of 0.88 (95% CI: 0.68-1.15 post-Dose 3. After Doses 2 and 3 of experimental vaccines, anti-CS and anti-HBs antibody GMTs were higher in children who had been previously vaccinated with at least one dose of hepatitis B vaccine compared to those not previously vaccinated.RTS,S/AS01(E proved similarly as well tolerated and immunogenic as RTS,S/AS02(D, completing an essential step in the age de-escalation process within the RTS,S clinical development plan.ClinicalTrials.gov. NCT00307021.

  2. Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.

    Science.gov (United States)

    Lauschke, Volker M; Hendriks, Delilah F G; Bell, Catherine C; Andersson, Tommy B; Ingelman-Sundberg, Magnus

    2016-12-19

    The liver is an organ with critical importance for drug treatment as the disposition and response to a given drug is often determined by its hepatic metabolism. Patient-specific factors can entail increased susceptibility to drug-induced liver injury, which constitutes a major risk for drug development programs causing attrition of promising drug candidates or costly withdrawals in postmarketing stages. Hitherto, mainly animal studies and 2D hepatocyte systems have been used for the examination of human drug metabolism and toxicity. Yet, these models are far from satisfactory due to extensive species differences and because hepatocytes in 2D cultures rapidly dedifferentiate resulting in the loss of their hepatic phenotype and functionality. With the increasing comprehension that 3D cell culture systems more accurately reflect in vivo physiology, in the recent decade more and more research has focused on the development and optimization of various 3D culture strategies in an attempt to preserve liver properties in vitro. In this contribution, we critically review these developments, which have resulted in an arsenal of different static and perfused 3D models. These systems include sandwich-cultured hepatocytes, spheroid culture platforms, and various microfluidic liver or multiorgan biochips. Importantly, in many of these models hepatocytes maintain their phenotype for prolonged times, which allows probing the potential of newly developed chemical entities to cause chronic hepatotoxicity. Moreover, some platforms permit the investigation of drug action in specific genetic backgrounds or diseased hepatocytes, thereby significantly expanding the repertoire of tools to detect drug-induced liver injuries. It is concluded that the development of 3D liver models has hitherto been fruitful and that systems are now at hand whose sensitivity and specificity in detecting hepatotoxicity are superior to those of classical 2D culture systems. For the future, we highlight the

  3. The Role of Alternative Testing Strategies in Environmental Risk Assessment of Engineered Nanomaterials

    OpenAIRE

    Hjorth, Rune; Holden, Patricia; Hansen, Steffen Foss; Colman, Ben; Grieger, Khara; Hendren, Christine

    2017-01-01

    Within toxicology there is a pressure to find new test systems and organisms to replace, reduce and refine animal testing. In nanoecotoxicology the need for alternative testing strategies (ATS) is further emphasized as the validity of tests and risk assessment practices developed for dissolved chemicals are challenged. Nonetheless, standardized whole organism animal testing is still considered the gold standard for environmental risk assessment. Advancing risk analysis of engineered nanomater...

  4. An assessment of drug testing within the construction industry.

    Science.gov (United States)

    Gerber, Jonathan K; Yacoubian, George S

    2002-01-01

    Drug testing in the workplace has gone from virtual nonexistence to widespread employer acceptance during the past two decades. This growth is particularly significant for the construction industry. High rates of alcohol and other drug use, coupled with the high-risk, safety-sensitive nature of the industry, have prompted the development of a variety of drug surveillance and prevention strategies. Despite this growing vigilance, no scholarly works have examined the impact of drug-related policies in the construction industry. To address this limitation, we investigate the efficacy of workplace drug-testing programs in reducing injury incident rates and workers' compensation experience-rating modification factors (MODs) within the construction industry. Analyses indicate that companies with drug-testing programs experienced a 51 percent reduction in incident rates within two years of implementation. Moreover, companies that drug test their employees experienced a significant reduction in their MODs. Policy implications are discussed in light of the current findings.

  5. Relationship between candidate communication ability and oral certification examination scores.

    Science.gov (United States)

    Lunz, Mary E; Bashook, Philip G

    2008-12-01

    Structured case-based oral examinations are widely used in medical certifying examinations in the USA. These orals assess the candidate's decision-making skills using real or realistic patient cases. Frequently mentioned but not empirically evaluated is the potential bias introduced by the candidate's communication ability. This study aimed to assess the relationship between candidate communication ability and medical certification oral examination scores. Non-doctor communication observers rated a random sample of 90 candidates on communication ability during a medical oral certification examination. The multi-facet Rasch model was used to analyse the communication survey and the oral examination data. The multi-facet model accounts for observer and examiner severity bias. anova was used to measure differences in communication ability between passing and failing candidates and candidates grouped by level of communication ability. Pearson's correlations were used to compare candidate communication ability and oral certification examination performance. Candidate separation reliability values for the communication survey and the oral examination were 0.85 and 0.97, respectively, suggesting accurate candidate measurement. The correlation between communication scores and oral examination scores was 0.10. No significant difference was found between passing and failing candidates for measured communication ability. When candidates were grouped by high, moderate and low communication ability, there was no significant difference in their oral certification examination performance. Candidates' communication ability has little relationship to candidate performance on high-stakes, case-based oral examinations. Examiners for this certifying examination focused on assessing candidate decision-making ability and were not influenced by candidate communication ability.

  6. The Vitotox and ToxTracker assays: A two-test combination for quick and reliable assessment of genotoxic hazards.

    Science.gov (United States)

    Ates, Gamze; Favyts, Dorien; Hendriks, Giel; Derr, Remco; Mertens, Birgit; Verschaeve, Luc; Rogiers, Vera; Y Doktorova, Tatyana

    2016-11-01

    To ensure safety for humans, it is essential to characterize the genotoxic potential of new chemical entities, such as pharmaceutical and cosmetic substances. In a first tier, a battery of in vitro tests is recommended by international regulatory agencies. However, these tests suffer from inadequate specificity: compounds may be wrongly categorized as genotoxic, resulting in unnecessary, time-consuming, and expensive in vivo follow-up testing. In the last decade, novel assays (notably, reporter-based assays) have been developed in an attempt to overcome these drawbacks. Here, we have investigated the performance of two in vitro reporter-based assays, Vitotox and ToxTracker. A set of reference compounds was selected to span a variety of mechanisms of genotoxic action and applicability domains (e.g., pharmaceutical and cosmetic ingredients). Combining the performance of the two assays, we achieved 93% sensitivity and 79% specificity for prediction of gentoxicity for this set of compounds. Both assays permit quick high-throughput analysis of drug candidates, while requiring only small quantities of the test substances. Our study shows that these two assays, when combined, can be a reliable method for assessment of genotoxicity hazard. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. New Rock Abrasivity Test Method for Tool Life Assessments on Hard Rock Tunnel Boring: The Rolling Indentation Abrasion Test (RIAT)

    Science.gov (United States)

    Macias, F. J.; Dahl, F.; Bruland, A.

    2016-05-01

    The tunnel boring machine (TBM) method has become widely used and is currently an important presence within the tunnelling industry. Large investments and high geological risk are involved using TBMs, and disc cutter consumption has a great influence on performance and cost, especially in hard rock conditions. Furthermore, reliable cutter life assessments facilitate the control of risk as well as avoiding delays and budget overruns. Since abrasive wear is the most common process affecting cutter consumption, good laboratory tests for rock abrasivity assessments are needed. A new abrasivity test method by rolling disc named Rolling Indentation Abrasion Test (RIAT) has been developed. The goal of the new test design and procedure is to reproduce wear behaviour on hard rock tunnel boring in a more realistic way than the traditionally used methods. Wear by rolling contact on intact rock samples is introduced and several rock types, covering a wide rock abrasiveness range, have been tested by RIAT. The RIAT procedure indicates a great ability of the testing method to assess abrasive wear on rolling discs. In addition and to evaluate the newly developed RIAT test method, a comprehensive laboratory testing programme including the most commonly used abrasivity test methods and the mineral composition were carried out. Relationships between the achieved results from conventional testing and RIAT results have been analysed.

  8. Testing of Some Canine Blood Types in Transfusion Compatibility Assessment

    Directory of Open Access Journals (Sweden)

    L Ognean

    2014-01-01

    Full Text Available Blood types were determined using SHIGETA (n=136 and DEA1.1 (n=25 kits, in two groups of dogs, consisting of patients that underwent blood transfusions and healthy donors. The tests were conducted in accordance with the procedures established by the manufacturers, using specific monoclonal antibodies kits, heparinized blood for the tube agglutination (TUBE and slide (SLIDE methods, and EDTA treated blood for the CARD and chromatographic (CHROM methods. The clear expression of tube agglutination reaction in the SHIGETA kit provided a good detection of antigens. Positive reactions with anti-DEA1.1 were clear and evident with the CHROM test. SHIGETA tests revealed a predominance 1.1B (47.05% of blood type, common in Rotweilers (81.81% and Romanian Shepherds (73.68% and group 1(-B (24.26%, frequently found in German Shepherds (54.16%, these also representing an important source of compatible blood. DEA1.1 type test, revealed a high frequency of positive dogs (75%, associated with lower number of potential donors. Extrapolation of SHIGETA groups into the DEA system, confirmed the 1(-B positive dogs as DEA 1.1 negative, and their prevalence in German Shepherds also confirmed their known tendency to be “ideal donors”. The CHROME test showed a good efficiency in auto agglutination control and detecting DEA1.1 positive dogs, including patients with severe forms of anemia.

  9. Assessment Guide for Educators: A Content Comparison--2002 Series Test and the Current GED® Test

    Science.gov (United States)

    GED Testing Service, 2017

    2017-01-01

    This report provides a content comparison for the 2002 Series GED® test and the current GED® for the following test topic areas: (1) Mathematical Reasoning; (2) Reasoning through Language Arts; (3) Science; and (4) Social Studies.

  10. Pyrosequencing-based assessment of the bacteria diversity in surface and subsurface peat layers of a northern wetland, with focus on poorly studied phyla and candidate divisions.

    Science.gov (United States)

    Serkebaeva, Yulia M; Kim, Yongkyu; Liesack, Werner; Dedysh, Svetlana N

    2013-01-01

    Northern peatlands play a key role in the global carbon and water budget, but the bacterial diversity in these ecosystems remains poorly described. Here, we compared the bacterial community composition in the surface (0-5 cm depth) and subsurface (45-50 cm) peat layers of an acidic (pH 4.0) Sphagnum-dominated wetland, using pyrosequencing of 16S rRNA genes. The denoised sequences (37,229 reads, average length ∼430 bp) were affiliated with 27 bacterial phyla and corresponded to 1,269 operational taxonomic units (OTUs) determined at 97% sequence identity. Abundant OTUs were affiliated with the Acidobacteria (35.5±2.4% and 39.2±1.2% of all classified sequences in surface and subsurface peat, respectively), Alphaproteobacteria (15.9±1.7% and 25.8±1.4%), Actinobacteria (9.5±2.0% and 10.7±0.5%), Verrucomicrobia (8.5±1.4% and 0.6±0.2%), Planctomycetes (5.8±0.4% and 9.7±0.6%), Deltaproteobacteria (7.1±0.4% and 4.4%±0.3%), and Gammaproteobacteria (6.6±0.4% and 2.1±0.1%). The taxonomic patterns of the abundant OTUs were uniform across all the subsamples taken from each peat layer. In contrast, the taxonomic patterns of rare OTUs were different from those of the abundant OTUs and varied greatly among subsamples, in both surface and subsurface peat. In addition to the bacterial taxa listed above, rare OTUs represented the following groups: Armatimonadetes, Bacteroidetes, Chlamydia, Chloroflexi, Cyanobacteria, Elusimicrobia, Fibrobacteres, Firmicutes, Gemmatimonadetes, Spirochaetes, AD3, WS1, WS4, WS5, WYO, OD1, OP3, BRC1, TM6, TM7, WPS-2, and FCPU426. OTU richness was notably higher in the surface layer (882 OTUs) than in the anoxic subsurface peat (483 OTUs), with only 96 OTUs common to both data sets. Most members of poorly studied phyla, such as the Acidobacteria, Verrucomicrobia, Planctomycetes and the candidate division TM6, showed a clear preference for growth in either oxic or anoxic conditions. Apparently, the bacterial communities in surface and

  11. Assessment of three substrata for maize seed testing | Ajayi | African ...

    African Journals Online (AJOL)

    Traits assessed were germination percentage, emergence index, number of primary roots, and root and shoot lengths. The experiment was repeated four times. Substratum had highly significant effect on number of primary roots and root and shoot lengths but not on germination percentage and emergence index.

  12. Development and Validation of the Personality Assessment Questionnaire: Test Manual.

    Science.gov (United States)

    Rohner, Ronald P.; And Others

    Data are presented evaluating the validity and reliability of the Personality Assessment Questionnaire (PAQ), a self-report questionnaire designed to elicit respondents' perceptions of themselves with respect to seven personality and behavioral dispositions: hostility and aggression, dependence, self-esteem, self-adequacy, emotional…

  13. Seismic hazard assessment for the Caucasus test area

    Czech Academy of Sciences Publication Activity Database

    Balassanian, S.; Ashirov, T.; Chelidze, T.; Gassanov, A.; Kondorskaya, N.; Molchan, G.; Pustovitenko, B.; Trifonov, V.; Ulomov, V.; Giardini, D.; Erdik, M.; Ghafory-Ashtiany, M.; Grunthal, G.; Mayer-Rosa, D.; Schenk, Vladimír; Stucchi, M.

    1999-01-01

    Roč. 42, č. 6 (1999), s. 1139-1151 ISSN 0365-2556 R&D Projects: GA AV ČR Global Seismic Hazard Assessment Program (GSHAP) - project of the UN International Decade of Natural Disaster Reduction and International Litosphere Program. Subject RIV: DC - Siesmology, Volcanology, Earth Structure

  14. Platelet function testing: methods of assessment and clinical utility.

    LENUS (Irish Health Repository)

    Mylotte, Darren

    2012-02-01

    Platelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.

  15. Platelet function testing: methods of assessment and clinical utility.

    LENUS (Irish Health Repository)

    Mylotte, Darren

    2011-01-01

    Platelets play a central role in the regulation of both thrombosis and haemostasis yet tests of platelet function have, until recently, been exclusively used in the diagnosis and management of bleeding disorders. Recent advances have demonstrated the clinical utility of platelet function testing in patients with cardiovascular disease. The ex vivo measurement of response to antiplatelet therapies (aspirin and clopidogrel), by an ever-increasing array of platelet function tests, is with some assays, predictive of adverse clinical events and thus, represents an emerging area of interest for both the clinician and basic scientist. This review article will describe the advantages and disadvantages of the currently available methods of measuring platelet function and discuss both the limitations and emerging data supporting the role of platelet function studies in clinical practice.

  16. Assessing Old and New Diagnostic Tests for Gastroesophageal Reflux Disease.

    Science.gov (United States)

    Vaezi, Michael F; Sifrim, Daniel

    2018-01-01

    A detailed critique of objective measurements of gastroesophageal reflux disease (GERD) would improve management of patients suspecting of having reflux, leading to rational selection of treatment and better outcomes. Many diagnostic tests for GERD have been developed over the past decades. We analyze their development, positive- and negative-predictive values, and ability to predict response to treatment. These features are important for development of medical, surgical, and endoscopic therapies for GERD. We discuss the value of available diagnostic tests and review their role in management of patients with persistent reflux symptoms despite adequate medical or surgical treatment. This is becoming a significant health economic problem, due to the widespread use of proton pump inhibitors. GERD is believed to cause nonesophageal symptoms, such as those provoked by ear, nose, throat, or respiratory disorders. We analyze the value of GERD diagnostic tests in evaluation of these troublesome, nonesophageal symptoms. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

  17. Assessment of SPACE Code Using the LSTF 10% MSLB Test

    International Nuclear Information System (INIS)

    Kim, Yo Han; Yang, Chang Keun; Ha, Sang Jun

    2012-01-01

    The Korea Nuclear Hydro and Nuclear Power Co. (KHNP) has developed a multipurpose nuclear safety analysis code called the Safety and Performance Analysis Code for Nuclear Power Plants (SPACE). The SPACE is a best-estimated two-phase three-field thermal-hydraulic analysis code used to analyze the safety and performance of pressurized water reactors (PWRs). As in the second phase of the project, the beta version of the code has been developed through the validation and verification (V and V) using integral loop test data or plant operating data and the complement of code to solve the SPACE code user problem and resolution reports. In this study, the Large Scale Test Facility (LSTF) 10% main steam line break (MSLB) test, SB-SL-01, was simulated as a V and V work. The results were compared with the experimental data and those of the RELAP5/MOD3.1 code simulation

  18. R and D needs assessment for the Engineering Test Facility

    International Nuclear Information System (INIS)

    1980-10-01

    The Engineering Test Facility (ETF), planned to be the next major US magnetic fusion device, has its mission (1) to provide the capability for moving into the engineering phase of fusion development and (2) to provide a test-bed for reactor components in a fusion environment. The design, construction, and operation of the ETF requires an increasing emphasis on certain key research and development (R and D) programs in magnetic fusion in order to provide the necessary facility design base. This report identifies these needs and discusses the apparent inadequacies of the presently planned US program to meet them, commensurate with the ETF schedule

  19. Operational Based Vision Assessment Cone Contrast Test: Description and Operation

    Science.gov (United States)

    2016-06-02

    time and even between monitors from the same manufacturer. Because of this, the system will include a colorimeter that can test the system to see if...it is in the proper state. If the system is out of calibration, the colorimeter and custom software can be used to return the system to the

  20. A Control Systems Concept Inventory Test Design and Assessment

    Science.gov (United States)

    Bristow, M.; Erkorkmaz, K.; Huissoon, J. P.; Jeon, Soo; Owen, W. S.; Waslander, S. L.; Stubley, G. D.

    2012-01-01

    Any meaningful initiative to improve the teaching and learning in introductory control systems courses needs a clear test of student conceptual understanding to determine the effectiveness of proposed methods and activities. The authors propose a control systems concept inventory. Development of the inventory was collaborative and iterative. The…

  1. Physics and engineering assessments of spherical torus component test facility

    International Nuclear Information System (INIS)

    Peng, Y.-K.M.; Neumeyer, C.A.; Kessel, C.; Rutherford, P.; Mikkelsen, D.; Bell, R.; Menard, J.; Gates, D.; Schmidt, J.; Synakowski, E.; Grisham, L.; Fogarty, P.J.; Strickler, D.J.; Burgess, T.W.; Tsai, J.; Nelson, B.E.; Sabbagh, S.; Mitarai, O.; Cheng, E.T.; El-Guebaly, L.

    2005-01-01

    A broadly based study of the fusion engineering and plasma science conditions of a Component Test Facility (CTF), using the Spherical Torus or Spherical Tokamak (ST) configuration, have been carried out. The chamber systems testing conditions in a CTF are characterized by high fusion neutron fluxes Γ n > 4.4x10 13 n/s/cm 2 , over size scales > 10 5 cm 2 and depth scales > 50 cm, delivering > 3 accumulated displacement per atom (dpa) per year. The desired chamber conditions can be provided by a CTF with R 0 1.2 m, A = 1.5, elongation ∼ 3.2, I p ∼ 9 MA, B T ∼ 2.5 T, producing a driven fusion burn using 36 MW of combined neutral beam and RF power. Relatively robust ST plasma conditions are adequate, which have been shown achievable [4] without active feedback manipulation of the MHD modes. The ST CTF will test the single-turn, copper alloy center leg for the toroidal field coil without an induction solenoid and neutron shielding, and require physics data on solenoid-free plasma current initiation, ramp-up, and sustainment to multiple MA level. A new systems code that combines the key required plasma and engineering science conditions of CTF has been prepared and utilized as part of this study. The results show high potential for a family of lowercost CTF devices to suit a variety of fusion engineering science test missions. (author)

  2. STS-133/ET-137 Tanking Test Photogrammetry Assessment

    Science.gov (United States)

    Oliver, Stanley T.

    2012-01-01

    Following the launch scrub of Space Shuttle mission STS-133 on November 5, 2010, an anomalous condition of cracked and raised thermal protection system (TPS) foam was observed on the External Tank (ET). Subsequent dissection of the affected TPS region revealed cracks in the feet of two Intertank (IT) metallic stringers. An extensive investigation into the cause(s) and corrective action(s) for the cracked stringers was initiated, involving a wide array of material and structural tests and nondestructive evaluations, with the intent to culminate into the development of flight rational. One such structural test was the instrumented tanking test performed on December 17, 2010. The tanking test incorporated two three-dimensional optical displacement measurement systems to measure full-field outer surface displacements of the TPS surrounding the affected region that contained the stringer cracks. The results showed that the radial displacement and rotation of the liquid oxygen (LO2) tank flange changed significantly as the fluid level of the LO2 approached and passed the LO2 tank flange.

  3. Health literacy assessment: relexicalising a US test for a South ...

    African Journals Online (AJOL)

    It is an objective vocabulary test, designed as a screening instrument to identify the health literacy levels of patients in clinics, which uses item recognition of 66 ... of the REALM, using words gathered from health information and promotional texts in local clinics, hypothesising that this would improve its applicability.

  4. Laboratory testing and assessment of the Pickering PRD supporting frame

    International Nuclear Information System (INIS)

    Ghobarah, A.

    1995-05-01

    The objective of this study was to design and test reinforced concrete beam-column subassemblages representing the beam, column and joint of the Centre Pier (CP) support of the Pressure Relief Duct (PRD) at the Pickering A Nuclear Generating Station. The testing program was expected to establish the failure mode of the subassemblage and to compare the performance of the existing CP with a specimen detailed in accordance with current code provisions. A one-third scale specimen of the beam-column subassemblage was designed and tested to failure when subjected to simulated seismic loads. A second specimen was constructed with shear reinforcement that was detailed according to the provisions of the CAN3-N287.3-M82 code. The second specimen was tested in the same manner as the first specimen. From the experimental data on the behaviour and mode of failure of the specimens, analytical evaluations were conducted to determine the inelastic nonlinear behaviour of the CP structural system when subjected to various levels of ground motion. (author). 11 refs., 3 tabs., 40 figs

  5. Deriving Oral Assessment Scales across Different Tests and Rater Groups.

    Science.gov (United States)

    Chalhoub-Deville, Micheline

    1995-01-01

    The purpose of this study was to derive the criteria/dimensions underlying learners' second-language oral ability scores across three tests: an oral interview, a narration, and a read-aloud. A stimulus tape of 18 speech samples was presented to 3 native speaker rater groups for evaluation. Results indicate that researchers might need to reconsider…

  6. Direct Tensile Test to Assess Healing in Asphalt

    NARCIS (Netherlands)

    Leegwater, G.A.; Scarpas, Athanasios; Erkens, Sandra

    2016-01-01

    Asphalt concrete has the advantageous ability to heal. During rest
    periods, damage present In the material is restored to a certain extent.
    Healing of the material can be observed in iis regaining of strength
    and stiffness after rest periods. In this paper, a new test method is

  7. Direct tensile test to assess healing in asphalt

    NARCIS (Netherlands)

    Leegwater, G.A.; Scarpas, T.; Erkens, S.

    2016-01-01

    Asphalt concrete has the advantageous ability to heal. During rest periods, damage present in the material is restored to a certain extent. Healing of the material can be observed in its regaining of strength and stiffness after rest periods. In this paper, a new test method is presented. It was

  8. Results of the Minnesota Multiphasic Personality Inventory-2 among gestational surrogacy candidates.

    Science.gov (United States)

    Klock, Susan C; Covington, Sharon N

    2015-09-01

    To obtain normative data on the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) personality test for gestational surrogate (GS) candidates. A retrospective study was undertaken through chart review of all GS candidates assessed at Shady Grove Fertility Center, Rockville, MD, USA, between June 2007 and December 2009. Participants completed the MMPI-2 test during screening. MMPI-2 scores, demographic information, and screening outcome were retrieved. Among 153 included candidates, 132 (86.3%) were accepted to be a GS, 6 (3.9%) were ruled out because of medical reasons, and 15 (9.8%) were ruled out because of psychological reasons. The mean scores on each of the MMPI-2 scales were within the normal range. A score of more than 65 (the clinical cutoff) was recorded on the L scale for 46 (30.1%) candidates, on the K scale for 61 (39.9%), and on the S scale for 84 (54.9%). Women who were ruled out for psychological reasons had significantly higher mean scores on the validity scales F and L, and on clinical scale 8 than did women who were accepted (P<0.05 for all). Most GS candidates are well adjusted and free of psychopathology, but candidates tend to present themselves in an overly positive way. Copyright © 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  9. Test manufacturing of copper canisters with cast inserts. Assessment report

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, C.G

    1998-08-01

    The current design of canisters for the deep repository for spent nuclear fuel consists of an outer corrosion-protective copper casing in the form of a tubular section with lid and bottom and an inner pressure-resistant insert. The insert is designed to be manufactured by casting and inside are channels in which the fuel assemblies are to be placed. Over the last years, a number of full-scale manufacturing tests of all canister components have been carried out. The purpose has been to determine and develop the best manufacturing technique and to establish long-term contacts with the best suppliers of material and technology. Part of the work has involved the developing and implementing of a quality assurance system in accordance with ISO 9001, covering the whole chain from suppliers of material up to and including the delivery of assembled canisters. This report consists of a description of the design of the canister together with current drawings and complementary technical specifications stipulating, among other things, requirements placed on different materials. The different manufacturing methods that have been used are also described and commented on in both text and illustrations. For the manufacturing of copper tubes, the roll-forming of rolled plate to tube halves and longitudinal welding is a method that has been tested on a relatively large number of tubes by now, and that probably can be developed into a functioning production method. However, the very promising outcome of performed tests on seamless tube manufacturing, has resulted in a change in direction in tube manufacturing, focusing on continued testing of extrusion as well as pierce and draw processing in the immediate future. In connection with ongoing operations, new manufacturing tests of tubes with less material thickness will be carried out. Test manufacturing of cast inserts has resulted in the choice of nodular iron as material in the continued work. This improvement in design has resulted

  10. Test manufacturing of copper canisters with cast inserts. Assessment report

    International Nuclear Information System (INIS)

    Andersson, C.G.

    1998-08-01

    The current design of canisters for the deep repository for spent nuclear fuel consists of an outer corrosion-protective copper casing in the form of a tubular section with lid and bottom and an inner pressure-resistant insert. The insert is designed to be manufactured by casting and inside are channels in which the fuel assemblies are to be placed. Over the last years, a number of full-scale manufacturing tests of all canister components have been carried out. The purpose has been to determine and develop the best manufacturing technique and to establish long-term contacts with the best suppliers of material and technology. Part of the work has involved the developing and implementing of a quality assurance system in accordance with ISO 9001, covering the whole chain from suppliers of material up to and including the delivery of assembled canisters. This report consists of a description of the design of the canister together with current drawings and complementary technical specifications stipulating, among other things, requirements placed on different materials. The different manufacturing methods that have been used are also described and commented on in both text and illustrations. For the manufacturing of copper tubes, the roll-forming of rolled plate to tube halves and longitudinal welding is a method that has been tested on a relatively large number of tubes by now, and that probably can be developed into a functioning production method. However, the very promising outcome of performed tests on seamless tube manufacturing, has resulted in a change in direction in tube manufacturing, focusing on continued testing of extrusion as well as pierce and draw processing in the immediate future. In connection with ongoing operations, new manufacturing tests of tubes with less material thickness will be carried out. Test manufacturing of cast inserts has resulted in the choice of nodular iron as material in the continued work. This improvement in design has resulted

  11. Gas Test Loop Facilities Alternatives Assessment Report Rev 1

    International Nuclear Information System (INIS)

    William J. Skerjanc; William F. Skerjanc

    2005-01-01

    An important task in the Gas Test Loop (GTL) conceptual design was to determine the best facility to serve as host for this apparatus, which will allow fast-flux neutron testing in an existing nuclear facility. A survey was undertaken of domestic and foreign nuclear reactors and accelerator facilities to arrive at that determination. Two major research reactors in the U.S. were considered in detail, the Advanced Test Reactor (ATR) and the High Flux Isotope Reactor (HFIR), each with sufficient power to attain the required neutron fluxes. HFIR routinely operates near its design power limit of 100 MW. ATR has traditionally operated at less than half its design power limit of 250 MW. Both of these reactors should be available for at least the next 30 years. The other major U.S. research reactor, the Missouri University Research Reactor, does not have sufficient power to reach the required neutron flux nor do the smaller research reactors. Of the foreign reactors investigated, BOR-60 is perhaps the most attractive. Monju and BN 600 are power reactors for their respective electrical grids. Although the Joyo reactor is vigorously campaigning for customers, local laws regarding transport of radioactive material mean it would be very difficult to retrieve test articles from either Japanese reactor for post irradiation examination. PHENIX is scheduled to close in 2008 and is fully booked until then. FBTR is limited to domestic (Indian) users only. Data quality is often suspect in Russia. The only accelerator seriously considered was the Fuel and Material Test Station (FMTS) currently proposed for operation at Los Alamos National Laboratory. The neutron spectrum in FMTS is similar to that found in a fast reactor, but it has a pronounced high-energy tail that is atypical of fast fission reactor spectra. First irradiation in the FMTS is being contemplated for 2008. Detailed review of these facilities resulted in the recommendation that the ATR would be the best host for the GTL

  12. Systematic evaluation of candidate blood markers for detecting ovarian cancer.

    Directory of Open Access Journals (Sweden)

    Chana Palmer

    2008-07-01

    Full Text Available Epithelial ovarian cancer is a significant cause of mortality both in the United States and worldwide, due largely to the high proportion of cases that present at a late stage, when survival is extremely poor. Early detection of epithelial ovarian cancer, and of the serous subtype in particular, is a promising strategy for saving lives. The low prevalence of ovarian cancer makes the development of an adequately sensitive and specific test based on blood markers very challenging. We evaluated the performance of a set of candidate blood markers and combinations of these markers in detecting serous ovarian cancer.We selected 14 candidate blood markers of serous ovarian cancer for which assays were available to measure their levels in serum or plasma, based on our analysis of global gene expression data and on literature searches. We evaluated the performance of these candidate markers individually and in combination by measuring them in overlapping sets of serum (or plasma samples from women with clinically detectable ovarian cancer and women without ovarian cancer. Based on sensitivity at high specificity, we determined that 4 of the 14 candidate markers--MUC16, WFDC2, MSLN and MMP7--warrant further evaluation in precious serum specimens collected months to years prior to clinical diagnosis to assess their utility in early detection. We also reported differences in the performance of these candidate blood markers across histological types of epithelial ovarian cancer.By systematically analyzing the performance of candidate blood markers of ovarian cancer in distinguishing women with clinically apparent ovarian cancer from women without ovarian cancer, we identified a set of serum markers with adequate performance to warrant testing for their ability to identify ovarian cancer months to years prior to clinical diagnosis. We argued for the importance of sensitivity at high specificity and of magnitude of difference in marker levels between cases and

  13. Enhanced Cover Assessment Project:Soil Manipulation and Revegetation Tests

    Energy Technology Data Exchange (ETDEWEB)

    Waugh, W. Joseph [Navarro Research and Engineering, Inc.; Albright, Dr. Bill [Desert Research Inst. (DRI), Reno, NV (United States); Benson, Dr. Craig [University of Wisconsin-Madison

    2014-02-01

    The U.S. Department of Energy Office of Legacy Management is evaluating methods to enhance natural changes that are essentially converting conventional disposal cell covers for uranium mill tailings into water balance covers. Conventional covers rely on a layer of compacted clayey soil to limit exhalation of radon gas and percolation of rainwater. Water balance covers rely on a less compacted soil “sponge” to store rainwater, and on soil evaporation and plant transpiration (evapotranspiration) to remove stored water and thereby limit percolation. Over time, natural soil-forming and ecological processes are changing conventional covers by increasing hydraulic conductivity, loosening compaction, and increasing evapotranspiration. The rock armor on conventional covers creates a favorable habitat for vegetation by slowing soil evaporation, increasing soil water storage, and trapping dust and organic matter, thereby providing the water and nutrients needed for plant germination, survival, and sustainable transpiration. Goals and Objectives Our overall goal is to determine if allowing or enhancing these natural changes could improve cover performance and reduce maintenance costs over the long term. This test pad study focuses on cover soil hydrology and ecology. Companion studies are evaluating effects of natural and enhanced changes in covers on radon attenuation, erosion, and biointrusion. We constructed a test cover at the Grand Junction disposal site to evaluate soil manipulation and revegetation methods. The engineering design, construction, and properties of the test cover match the upper three layers of the nearby disposal cell cover: a 1-foot armoring of rock riprap, a 6-inch bedding layer of coarse sand and gravel, and a 2-foot protection layer of compacted fine soil. The test cover does not have a radon barrier—cover enhancement tests leave the radon barrier intact. We tested furrowing and ripping as means for creating depressions parallel to the slope

  14. Optimized candidal biofilm microtiter assay

    NARCIS (Netherlands)

    Krom, Bastiaan P.; Cohen, Jesse B.; Feser, Gail E. McElhaney; Cihlar, Ronald L.

    Microtiter based candidal biofilm formation is commonly being used. Here we describe the analysis of factors influencing the development of candidal biofilms such as the coating with serum, growth medium and pH. The data reported here show that optimal candidal biofilm formation is obtained when

  15. Spent LWR fuel leach tests: Waste Isolation Safety Assessment program

    International Nuclear Information System (INIS)

    Katayama, Y.B.

    1979-04-01

    Spent light-water-reactor (LWR) fuels with burnups of 54.5, 28 and 9 MWd/kgU were leach-tested in deionized water at 25 0 C. Fuel burnup has no apparent effect on the calculated leach rates based upon the behavior of 137 Cs and 239+240 Pu. A leach test of 54.5 MWd/kgU spent fuel in synthetic sea brine showed that the cesium-based leach rate is lower in sea brine than in deionized water. A rise in the leach rate was observed after approximately 600 d of cumulative leaching. During the rise, the leach rate for all the measured radionuclides become nearly equal. Evidence suggests that exposure of new surfaces to the leachant may cause the increase. As a result, experimental work to study leaching mechanisms of spent fuel has been initiated. 22 figures

  16. Assessment of Aluminum FSW Joints Using Ultrasonic Testing

    Directory of Open Access Journals (Sweden)

    Adamus K.

    2017-12-01

    Full Text Available The paper concerns aluminum joints made using friction stir welding. Although in the aerospace industry there is a tendency to replace metal components with composites, aluminum continues to be a valuable material. Its share in the aircraft structures is the biggest among all structural metals. Lots of aluminum components are made of sheets and most of them require joining. Friction stir welding is a relatively new joining technology, particularly with regard to the sheets having a thickness of 1 mm or lower. The paper is dedicated to non-destructive testing of such joints using ultrasonic inspection. It was found that ultrasonic testing allows for distinguishing between joints without material discontinuities, joint with material discontinuities at the advancing side and joint with discontinuities extending through the whole width of the stir zone. During research only horizontally aligned defects were taken into account.

  17. Double-shell tank integrity assessments ultrasonic test equipment performance test

    Energy Technology Data Exchange (ETDEWEB)

    Pfluger, D.C.

    1996-09-26

    A double-shell tank (DST) inspection (DSTI) system was performance tested over three months until August 1995 at Pittsburgh, Pennsylvania, completing a contract initiated in February 1993 to design, fabricate, and test an ultrasonic inspection system intended to provide ultrasonic test (UT) and visual data to determine the integrity of 28 DSTs at Hanford. The DSTs are approximately one-million-gallon underground radioactive-waste storage tanks. The test was performed in accordance with a procedure (Jensen 1995) that included requirements described in the contract specification (Pfluger 1995). This report documents the results of tests conducted to evaluate the performance of the DSTI system against the requirements of the contract specification. The test of the DSTI system also reflects the performance of qualified personnel and operating procedures.

  18. An assessment of testing requirement impacts on nuclear thermal propulsion ground test facility design

    International Nuclear Information System (INIS)

    Shipers, L.R.; Ottinger, C.A.; Sanchez, L.C.

    1993-01-01

    Programs to develop solid core nuclear thermal propulsion (NTP) systems have been under way at the Department of Defense (DoD), the National Aeronautics and Space Administration (NASA), and the Department of Energy (DOE). These programs have recognized the need for a new ground test facility to support development of NTP systems. However, the different military and civilian applications have led to different ground test facility requirements. The Department of Energy (DOE) in its role as landlord and operator of the proposed research reactor test facilities has initiated an effort to explore opportunities for a common ground test facility to meet both DoD and NASA needs. The baseline design and operating limits of the proposed DoD NTP ground test facility are described. The NASA ground test facility requirements are reviewed and their potential impact on the DoD facility baseline is discussed

  19. Assessment of boundary lubrication in biodiesels by nanotribological tests

    International Nuclear Information System (INIS)

    Maru, Marcia M.; Almeida, Clara M.; Silva, Rui F.; Achete, Carlos A.

    2013-01-01

    Nanoscale measurements using atomic force microscopy are performed in order to scrutinize the friction phenomena observed in microscale ball-on-disc tribological tests under (boundary lubrication) BL regime. Two reference biodiesels, one derived from a vegetable source (soybean) and the other from animal fat, are compared. A linear dependence of the friction coefficient (μ) with the Stribeck parameter (S = viscosity × velocity/load) is observed: μ = 0.11 − 26.54 × S for the animal fat and μ = 0.12 − 51.56 × S for the soybean biodiesel. The nanotribological tests allowed highlighting the cohesion component of friction force in the BL regime that is associated to the intrinsic characteristics of the biodiesels, the respective friction coefficients being μ = 0.0206 for the animal fat and μ = 0.0233 for the soybean biodiesel. The better lubricity of the animal fat biodiesel compared to the soybean observed in microscale is attributed to the presence of sulfur and to the higher amount of mono- and di-glycerides contaminants in it. The polarity and/or chemical affinity of the respective sulfur and OH groups facilitate them to reacting with the steel surfaces during the rubbing action. At nanoscale level, the same ranking in friction is observed among the biodiesels, being that here the friction phenomena are attributed to the cohesive forces other than those related to viscosity. - Highlights: • The frictional behavior of standard reference biodiesels is studied. • Nanotribology tests help scrutinizing microscale friction in boundary lubrication. • AFM tests allowed highlighting the cohesion component of friction in the BL regime. • Animal fat biodiesel promotes lower and more stable friction than soybean biodiesel

  20. GPR Laboratory Tests For Railways Materials Dielectric Properties Assessment

    Directory of Open Access Journals (Sweden)

    Francesca De Chiara

    2014-10-01

    Full Text Available In railways Ground Penetrating Radar (GPR studies, the evaluation of materials dielectric properties is critical as they are sensitive to water content, to petrographic type of aggregates and to fouling condition of the ballast. Under the load traffic, maintenance actions and climatic effects, ballast condition change due to aggregate breakdown and to subgrade soils pumping, mainly on existing lines with no sub ballast layer. The main purpose of this study was to validate, under controlled conditions, the dielectric values of materials used in Portuguese railways, in order to improve the GPR interpretation using commercial software and consequently the management maintenance planning. Different materials were tested and a broad range of in situ conditions were simulated in laboratory, in physical models. GPR tests were performed with five antennas with frequencies between 400 and 1800 MHz. The variation of the dielectric properties was measured, and the range of values that can be obtained for different material condition was defined. Additionally, in situ GPR measurements and test pits were performed for validation of the dielectric constant of clean ballast. The results obtained are analyzed and the main conclusions are presented herein.

  1. Unipedal stance testing in the assessment of peripheral neuropathy.

    Science.gov (United States)

    Hurvitz, E A; Richardson, J K; Werner, R A

    2001-02-01

    To define further the relation between unipedal stance testing and peripheral neuropathy. Prospective cohort. Electroneuromyography laboratory of a Veterans Affairs medical center and a university hospital. Ninety-two patients referred for lower extremity electrodiagnostic studies. A standardized history and physical examination designed to detect peripheral neuropathy, 3 trials of unipedal stance, and electrodiagnostic studies. Peripheral neuropathy was identified by electrodiagnostic testing in 32%. These subjects had a significantly shorter (p unipedal stance time (15.7s, longest of 3 trials) than the patients without peripheral neuropathy (37.1s). Abnormal unipedal stance time (unipedal stance time had a negative predictive value of 90%. Abnormal unipedal stance time was associated with an increased risk of having peripheral neuropathy on univariate analysis (odds ratio = 8.8, 95% confidence interval = 2.5--31), and was the only significant predictor of peripheral neuropathy in the regression model. Aspects of the neurologic examination did not add to the regression model compared with abnormal unipedal stance time. Unipedal stance testing is useful in the clinical setting both to identify and to exclude the presence of peripheral neuropathy.

  2. Environmental Hazard Assessment of Jarosite Waste Using Batch Leaching Tests

    Directory of Open Access Journals (Sweden)

    M. Kerolli – Mustafa

    2018-01-01

    Full Text Available Jarosite waste samples from Trepça Zinc Industry in Kosovo were subjected to two batch leaching tests as an attempt to characterize the leaching behavior and mobility of minor and major elements of jarosite waste. To achieve this, deionized water and synthetic acidic rain leaching tests were employed. A two-step acidic treatment in microwave digestion system were used to dissolve jarosite waste samples, followed by determination of Al, Ag, As, Ba, Cd, Co, Cr, Cu, Fe, Mn, Ni, P, Pb, S, Si, Sr, and Zn by inductively coupled plasma optical emission spectrometry (ICP-OES. The validation of the procedure was performed by the analysis of two geochemical reference materials, S JR-3 and S Jsy-1. Two toxicity leaching tests revealed a high metal releasing of Cd, Cu, Ni, Mn, Pb, Zn, and As, and the metal release risk for these elements is still very high due the low pH and acid rain. The statistical analysis showed useful data information on the relationship between elements in jarosite samples in two different extraction conditions (deionized water and synthetic acid rain.

  3. A Portable Environment Test System: A Field Assessment of Organotin Leachates--Test and Evaluation.

    Science.gov (United States)

    1987-11-01

    of organotin-based antifouling (AF) coatings, NOSC researchers used this facility to study the effects of tributyltin ( TBT ), the primary toxic ...Environmental Test System (PETS) was evaluated with tributyltin ( TBT ) anti oling leachates in Sin Diego Bay over a 7-month period. Overall mean test...EXECUTIVE SUMMARY A Portable Environmental Test System (PETS) was evaluated with tributyltin ( TBT ) antifouling leachates in San Diego Bay for 7

  4. Appropriate statistical methods are required to assess diagnostic tests for replacement, add-on, and triage

    NARCIS (Netherlands)

    Hayen, Andrew; Macaskill, Petra; Irwig, Les; Bossuyt, Patrick

    2010-01-01

    To explain which measures of accuracy and which statistical methods should be used in studies to assess the value of a new binary test as a replacement test, an add-on test, or a triage test. Selection and explanation of statistical methods, illustrated with examples. Statistical methods for

  5. Safety assessment document for the dynamic test complex (Building 836)

    International Nuclear Information System (INIS)

    Odell, B.N.; Pfeifer, H.E.

    1981-01-01

    A safety assessment was performed to determine if potential accidents at the 836 Complex at Site 300 could present undue hazards to the general public, personnel at Site 300, or have an adverse effect on the environment. The credible accidents that might have an effect on these facilities or have off-site consequences were considered. These were earthquake, extreme wind (including missiles), lightning, flood, criticality, high explosive (H) detonation that disperses uranium and beryllium, spontaneous oxidation of plutonium, explosions due to finely divided particles, and a fire

  6. Safety assessment document for the dynamic test complex (Building 836)

    Energy Technology Data Exchange (ETDEWEB)

    Odell, B.N.; Pfeifer, H.E.

    1981-11-24

    A safety assessment was performed to determine if potential accidents at the 836 Complex at Site 300 could present undue hazards to the general public, personnel at Site 300, or have an adverse effect on the environment. The credible accidents that might have an effect on these facilities or have off-site consequences were considered. These were earthquake, extreme wind (including missiles), lightning, flood, criticality, high explosive (H) detonation that disperses uranium and beryllium, spontaneous oxidation of plutonium, explosions due to finely divided particles, and a fire.

  7. Assessment of Color Vision Among School Children: A Comparative Study Between The Ishihara Test and The Farnsworth D-15 Test

    Directory of Open Access Journals (Sweden)

    Rajesh Kishor Shrestha

    2016-10-01

    Full Text Available Introduction: Color vision is one of the important attribute of visual perception. The study was conducted at different schools of Kathmandu to compare the  ndings of the Ishihara Pseudoisochromatic test and the Farnsworth D-15 test.  Method: A cross-sectional study was conducted among 2120 students of four schools of Kathmandu. Assessment included visual acuity measurement, slit lamp examination of anterior segment and fundus examination with direct ophthalmoscopy. Each student was assessed with the Ishihara pseudoisochromatic test and the Farnsworth D-15 test. The Chi-square test was performed to analyse color vision defect detected by the Ishihara test and the Farnsworth D-15 test. Results: A total of 2120 students comprising of 1114 males (52.5% and 1006 females (47.5% were recruited in the study with mean age of 12.2 years (SD 2.3 years. The prevalence of color vision defect as indicated by the Ishihara was 2.6 and as indicated by the D-15 test was 2.15 in males.  Conclusion: For school color vision screening, the Ishihara color test and the Farnsworth D-15 test have equal capacity to detect congenital color vision defect and they complement each other.  Keywords: color vision; children; defect; Farnsworth D-15; Ishihara.

  8. Test-Taking Strategies in L2 Assessment: The Test of English for International Communication Speaking Test.

    Science.gov (United States)

    Huang, Heng-Tsung Danny

    2016-08-01

    This research explored the test-taking strategies associated with the Test of English for International Communication Speaking Test (TOEIC-S) and their relationship with test performance. Capitalizing on two sets of TOEIC-S and a custom-made strategy inventory, the researcher collected data from a total of 215 Taiwanese English learners consisting of 84 males and 131 females with an average age of 20.1 years (SD = 2.6). Quantitative data analysis gave rise to three major findings. First, TOEIC-S test-taking strategy use constituted a multi-faceted construct that involved multiple types of strategic behaviors. Second, these strategic behaviors matched those allowing test-takers to communicate both in real life and in the workplace. Third, communication strategy use and cognitive strategy use both contributed significantly to TOEIC-S performance. © The Author(s) 2016.

  9. Psychological testing and psychological assessment. A review of evidence and issues.

    Science.gov (United States)

    Meyer, G J; Finn, S E; Eyde, L D; Kay, G G; Moreland, K L; Dies, R R; Eisman, E J; Kubiszyn, T W; Reed, G M

    2001-02-01

    This article summarizes evidence and issues associated with psychological assessment. Data from more than 125 meta-analyses on test validity and 800 samples examining multimethod assessment suggest 4 general conclusions: (a) Psychological test validity is strong and compelling, (b) psychological test validity is comparable to medical test validity, (c) distinct assessment methods provide unique sources of information, and (d) clinicians who rely exclusively on interviews are prone to incomplete understandings. Following principles for optimal nomothetic research, the authors suggest that a multimethod assessment battery provides a structured means for skilled clinicians to maximize the validity of individualized assessments. Future investigations should move beyond an examination of test scales to focus more on the role of psychologists who use tests as helpful tools to furnish patients and referral sources with professional consultation.

  10. Contact allergy to popular perfumes; assessed by patch test, use test and chemical analysis.

    Science.gov (United States)

    Johansen, J D; Rastogi, S C; Menné, T

    1996-09-01

    The frequency of contact allergy to the 10 best-selling women's perfumes was studied in 335 consecutive female eczema patients by patch testing. The diagnostic ability of the fragrance mix, in relation to these products, was evaluated. Of eczema patients, 6.9% had a positive patch test to one or more of the perfumes, and 56.5% of these had a concurrent positive reaction to the fragrance mix. Hence, testing with the patients' own cosmetics is a significant part of diagnosing perfume allergy. The clinical relevance of the patch-test reactions to the commercial perfumes was equal to that of the fragrance mix, as judged from the patient's history and use testing with one of the perfumes. At least three of the chemically defined sensitizers in the fragrance mix were detected in all the perfumes by gas chromatography-mass spectrometry, which indicates that the fragrance mix is a good imitation of actual exposure.

  11. Contact allergy to popular perfumes; assessed by patch test, use test and chemical analysis

    DEFF Research Database (Denmark)

    Johansen, J D; Rastogi, Suresh Chandra; Menné, T

    1996-01-01

    The frequency of contact allergy to the 10 best-selling women's perfumes was studied in 335 consecutive female eczema patients by patch testing. The diagnostic ability of the fragrance mix, in relation to these products, was evaluated. Of eczema patients, 6.9% had a positive patch test to one...... or more of the perfumes, and 56.5% of these had a concurrent positive reaction to the fragrance mix. Hence, testing with the patients' own cosmetics is a significant part of diagnosing perfume allergy. The clinical relevance of the patch-test reactions to the commercial perfumes was equal...... to that of the fragrance mix, as judged from the patient's history and use testing with one of the perfumes. At least three of the chemically defined sensitizers in the fragrance mix were detected in all the perfumes by gas chromatography-mass spectrometry, which indicates that the fragrance mix is a good imitation...

  12. Integrating data-based decision making, Assessment for Learning and diagnostic testing in formative assessment

    NARCIS (Netherlands)

    van der Kleij, Fabienne; Vermeulen, Jorine; Schildkamp, Kim; Eggen, Theodorus Johannes Hendrikus Maria

    2015-01-01

    Recent research has highlighted the lack of a uniform definition of formative assessment, although its effectiveness is widely acknowledged. This paper addresses the theoretical differences and similarities amongst three approaches to formative assessment that are currently most frequently discussed

  13. Assessment of portal venous system patency in the liver transplant candidate: A prospective study comparing ultrasound, microbubble-enhanced colour Doppler ultrasound, with arteriography and surgery

    International Nuclear Information System (INIS)

    Marshall, M.M.; Beese, R.C.; Muiesan, P.; Sarma, D.I.; O'Grady, J.; Sidhu, P.S.

    2002-01-01

    AIM: To determine the role of microbubble-enhanced colour Doppler ultrasound (CDUS) in assessing portal venous patency prior to liver transplantation. MATERIALS AND METHODS: Over a 2-year period, all patients with chronic liver disease undergoing routine pre-transplant CDUS examination in whom the portal venous system was inadequately demonstrated were recruited to the study. CDUS was performed in 368 patients and 33 patients (9%) were recruited. A repeat CDUS examination following an intravenous bolus injection of the microbubble contrast agent Levovist[reg] (Schering Healthcare AG, Berlin, Germany) was performed. Diagnostic confidence was recorded on a free linear analogue scale for both examinations. Findings were compared with indirect portography and surgery. RESULTS: Of the 33 patients with sub-optimal baseline examinations, improvement in portal vein visualization was achieved in 31 patients (94%). Median diagnostic confidence increased from 50% (interquartile range 30-60) to 90% (interquartile range 75-98) (P < 0.001) following administration of Levovist[reg]. Overall accuracy of portal vein assessment using microbubble-enhanced CDUS in 15 patients in whom a definitive diagnosis was made within 2 months was 87%. CONCLUSION: Microbubble-enhanced CDUS is a simple, inexpensive adjunct to standard pre liver transplant screening of the portal vein. It is particularly helpful in patients with end-stage cirrhosis who are at high risk of portal vein thrombosis and in whom the conventional examination is sub-optimal.Marshall, M.M. et al. (2002)

  14. Salicytamide: a New Anti-inflammatory Designed Drug Candidate.

    Science.gov (United States)

    Guedes, Karen Marinho Maciel; Borges, Rosivaldo Santos; Fontes-Júnior, Enéas Andrade; Silva, Andressa Santa Brigida; Fernandes, Luanna Melo Pereira; Cartágenes, Sabrina Carvalho; Pinto, Ana Carla Godinho; Silva, Mallone Lopes; Queiroz, Luana Melo Diogo; Vieira, José Luís Fernandes; Sousa, Pergentino José Cunha; Maia, Cristiane Socorro Ferraz

    2018-04-13

    Salicytamide is a new drug developed through molecular modelling and rational drug design by the molecular association of paracetamol and salicylic acid. This study was conducted to assess the acute oral toxicity, antinociceptive, and antioedematogenic properties of salicytamide. Acute toxicity was based on the OECD 423 guidelines. Antinociceptive properties were investigated using the writhing, hot plate and formalin tests in Swiss mice. Antioedematogenic properties were evaluated using the carrageenan-induced paw oedema model and croton oil-induced dermatitis in Wistar rats. Salicytamide did not promote behavioural changes or animal deaths during acute oral toxicity evaluation. Furthermore, salicytamide exhibited peripheral antinociceptive activity as evidenced by the reduction in writhing behaviour (ED50 = 4.95 mg/kg) and licking time in the formalin test's inflammatory phase. Also, salicytamide elicited central antinociceptive activity on both hot plate test and formalin test's neurogenic phase. Additionally, salicytamide was effective in reducing carrageenan or croton oil-induced oedema formation. Overall, we have shown that salicytamide, proposed here as a new NSAID candidate, did not induce oral acute toxicity and elicited both peripheral antinociceptive effects (about 10-25 times more potent than its precursors in the writhing test) and antioedematogenic properties. Salicytamide also presented central antinociceptive activity, which seems to be mediated through opioid-independent mechanisms. These findings reveal salicytamide as a promising antinociceptive/antioedematogenic drug candidate.

  15. Leadership potential analysis of elementary school headmaster candidates in trenggalek region, east java Indonesia

    Science.gov (United States)

    Widodo, BS; Sulistinah

    2018-01-01

    Leadership is the important component that should be possessed by headmaster candidates. Headmaster with a strong leadership potential can make a better development for school so there are many people say that “school is headmaster itself”. This study was aimed to analyze leadership potential of elementary school headmaster candidates in Trenggalek region. The samples of this study were 46 teachers who followed headmaster selection. The measurement was conducted through Leadership Potential Assessment (LPA) and interview. The result showed that there were 24 of 46 teachers who followed the test and interview had a good leadership potential to lead the elementary school. Of 24 candidates who passed the test had a good result on leadership skill, as follows: 1) quick and urgent decision making, 2) critical decision making, 3) creative decision making, and decision making based on evident that implements the four leadership skill (influence, move, develop and empower).

  16. Biomarker assessment and molecular testing for prognostication in breast cancer.

    Science.gov (United States)

    Kos, Zuzana; Dabbs, David J

    2016-01-01

    Current treatment of breast cancer incorporates clinical, pathological and molecular data. Oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) define prognosis and identify tumours for targeted therapy, and remain the sole established single-molecule biomarkers defining the minimum breast cancer pathology data set. Ki67 remains one of the most promising yet controversial biomarkers in breast cancer, implemented routinely in some, but not all, pathology departments. Beyond the single-molecule biomarkers, a host of multigene expression tests have been developed to interrogate the driver pathways and biology of individual breast cancers to predict clinical outcome more accurately. A minority of these assays have entered into clinical practice. This review focuses on the established biomarkers of ER, PR and HER2, the controversial but clinically implemented biomarker Ki67 and the currently marketed gene expression signatures. © 2015 John Wiley & Sons Ltd.

  17. A NEW CLINICAL MUSCLE FUNCTION TEST FOR ASSESSMENT OF HIP EXTERNAL ROTATION STRENGTH: AUGUSTSSON STRENGTH TEST.

    Science.gov (United States)

    Augustsson, Jesper

    2016-08-01

    Dynamic clinical tests of hip strength applicable on patients, non-athletes and athletes alike, are lacking. The aim of this study was therefore to develop and evaluate the reliability of a dynamic muscle function test of hip external rotation strength, using a novel device. A second aim was to determine if gender differences exist in absolute and relative hip strength using the new test. Fifty-three healthy sport science students (34 women and 19 men) were tested for hip external rotation strength using a device that consisted of a strap connected in series with an elastic resistance band loop, and a measuring tape connected in parallel with the elastic resistance band. The test was carried out with the subject side lying, positioned in 45 ° of hip flexion and the knees flexed to 90 ° with the device firmly fastened proximally across the knees. The subject then exerted maximal concentric hip external rotation force against the device thereby extending the elastic resistance band. The displacement achieved by the subject was documented by the tape measure and the corresponding force production was calculated. Both right and left hip strength was measured. Fifteen of the subjects were tested on repeated occasions to evaluate test-retest reliability. No significant test-retest differences were observed. Intra-class correlation coefficients ranged 0.93-0.94 and coefficients of variation 2.76-4.60%. In absolute values, men were significantly stronger in hip external rotation than women (right side 13.2 vs 11.0 kg, p = 0.001, left side 13.2 vs 11.5 kg, p = 0.002). There were no significant differences in hip external rotation strength normalized for body weight (BW) between men and women (right side 0.17 kg/BW vs 0.17 kg/BW, p = 0.675, left side 0.17 kg/BW vs 0.18 kg/BW, p = 0.156). The new muscle function test showed high reliability and thus could be useful for measuring dynamic hip external rotation strength in patients, non-athletes and athletes

  18. [A new assessment for episodic memory. Episodic memory test and caregiver's episodic memory test].

    Science.gov (United States)

    Ojea Ortega, T; González Álvarez de Sotomayor, M M; Pérez González, O; Fernández Fernández, O

    2013-10-01

    The purpose of the episodic memory test and the caregiver's episodic memory test is to evaluate episodic memory according to its definition in a way that is feasible for families and achieves high degrees of sensitivity and specificity. We administered a test consisting of 10 questions about episodic events to 332 subjects, of whom 65 had Alzheimer's disease (AD), 115 had amnestic MCI (aMCI) and 152 showed no cognitive impairment according to Reisberg's global deterioration scale (GDS). We calculated the test's sensitivity and specificity to distinguish AD from episodic aMCI and from normal ageing. The area under the ROC curve for the diagnosis of aMCI was 0.94 and the best cut-off value was 20; for that value, sensitivity was 89% and specificity was 82%. For a diagnosis of AD, the area under the ROC curve was 0.99 and the best cut-off point was 17, with a sensitivity of 98% and a specificity of 91%. A subsequent study using similar methodology yielded similar results when the test was administered directly by the caregiver. The episodic memory test and the caregiver's episodic memory test are useful as brief screening tools for identifying patients with early-stage AD. It is suitable for use by primary care medical staff and in the home, since it can be administered by a caregiver. The test's limitations are that it must be administered by a reliable caregiver and the fact that it measures episodic memory only. Copyright © 2012 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

  19. Unilateral Arm Crank Exercise Test for Assessing Cardiorespiratory Fitness in Individuals with Hemiparetic Stroke

    DEFF Research Database (Denmark)

    Oyake, Kazuaki; Yamaguchi, Tomofumi; Oda, Chihiro

    2017-01-01

    Cardiorespiratory fitness assessment with leg cycle exercise testing may be influenced by motor impairments in the paretic lower extremity. Hence, this study examined the usefulness of a unilateral arm crank exercise test to assess cardiorespiratory fitness in individuals with stroke, including s...

  20. 78 FR 49287 - Environmental Assessment for Potential Lease Issuance and Marine Hydrokinetic Technology Testing...

    Science.gov (United States)

    2013-08-13

    ...; MMAA104000] Environmental Assessment for Potential Lease Issuance and Marine Hydrokinetic Technology Testing... important environmental issues associated with data collection and technology testing activities (76 FR... Availability of a Revised Environmental Assessment and a Finding of No Significant Impact. SUMMARY: BOEM has...

  1. Ecological-economical approach to assessment of environment state at the Semipalatinsk test site

    International Nuclear Information System (INIS)

    Chugunova, N.S.; Balykbaeva, S.Y.

    2002-01-01

    The paper presents methods used for ecological-economical assessment of the environment condition at the former Semipalatinsk Test Site. It also presents methodology of calculating ecological and economical parameters for different options. Besides, the paper provides data describing assessment of ecological and economical damage caused by defense establishment activities at the Semipalatinsk Test Site. (author)

  2. 78 FR 29698 - Availability of an Environmental Assessment for Field Testing a Canine Lymphoma Vaccine, DNA

    Science.gov (United States)

    2013-05-21

    ...] Availability of an Environmental Assessment for Field Testing a Canine Lymphoma Vaccine, DNA AGENCY: Animal and... Canine Lymphoma Vaccine, DNA. The environmental assessment, which is based on a risk analysis prepared to... biological product: Requester: Merial, Inc. Product: Canine Lymphoma Vaccine, DNA. Possible Field Test...

  3. Psychological Testing and Psychological Assessment: A Review of Evidence and Issues.

    Science.gov (United States)

    Meyer, Gregory J.; Finn, Stephen E.; Eyde, Lorraine D.; Kay, Gary G.; Moreland, Kevin L.; Dies, Robert R.; Eisman, Elena J.; Kubiszyn, Tom W.; Reed, Geoffrey M.

    2001-01-01

    Summarizes issues associated with psychological assessment, concluding that: psychological test validity is strong and is comparable to medical test validity; distinct assessment methods provide unique sources of information; and clinicians who rely solely on interviews are prone to incomplete understandings. Suggests that multimethod assessment…

  4. Fuzzy Treatment of Candidate Outliers in Measurements

    Directory of Open Access Journals (Sweden)

    Giampaolo E. D'Errico

    2012-01-01

    Full Text Available Robustness against the possible occurrence of outlying observations is critical to the performance of a measurement process. Open questions relevant to statistical testing for candidate outliers are reviewed. A novel fuzzy logic approach is developed and exemplified in a metrology context. A simulation procedure is presented and discussed by comparing fuzzy versus probabilistic models.

  5. Assessing Groundwater Model Uncertainty for the Central Nevada Test Area

    International Nuclear Information System (INIS)

    Pohll, Greg; Pohlmann, Karl; Hassan, Ahmed; Chapman, Jenny; Mihevc, Todd

    2002-01-01

    The purpose of this study is to quantify the flow and transport model uncertainty for the Central Nevada Test Area (CNTA). Six parameters were identified as uncertain, including the specified head boundary conditions used in the flow model, the spatial distribution of the underlying welded tuff unit, effective porosity, sorption coefficients, matrix diffusion coefficient, and the geochemical release function which describes nuclear glass dissolution. The parameter uncertainty was described by assigning prior statistical distributions for each of these parameters. Standard Monte Carlo techniques were used to sample from the parameter distributions to determine the full prediction uncertainty. Additional analysis is performed to determine the most cost-beneficial characterization activities. The maximum radius of the tritium and strontium-90 contaminant boundary was used as the output metric for evaluation of prediction uncertainty. The results indicate that combining all of the uncertainty in the parameters listed above propagates to a prediction uncertainty in the maximum radius of the contaminant boundary of 234 to 308 m and 234 to 302 m, for tritium and strontium-90, respectively. Although the uncertainty in the input parameters is large, the prediction uncertainty in the contaminant boundary is relatively small. The relatively small prediction uncertainty is primarily due to the small transport velocities such that large changes in the uncertain input parameters causes small changes in the contaminant boundary. This suggests that the model is suitable in terms of predictive capability for the contaminant boundary delineation

  6. Assessment of Pipe Wall Loss Using Guided Wave Testing

    International Nuclear Information System (INIS)

    Joo, Kyung Mun; Jin, Seuk Hong; Moon, Yong Sig

    2010-01-01

    Flow accelerated corrosion(FAC) of carbon steel pipes in nuclear power plants has been known as one of the major degradation mechanisms. It could have bad influence on the plant reliability and safety. Also detection of FAC is a significant cost to the nuclear power plant because of the need to remove and replace insulation. Recently, the interest of the guided wave testing(GWT) has grown because it allows long range inspection without removing insulation of the pipe except at the probe position. If GWT can be applied to detection of FAC damages, it will can significantly reduce the cost for the inspection of the pipes. The objective of this study was to determine the capability of GWT to identify location of FAC damages. In this paper, three kinds of techniques were used to measure the amplitude ratio between the first and the second welds at the elbow area of mock-ups that contain real FAC damages. As a result, optimal inspection technique and minimum detectability to detect FAC damages drew a conclusion

  7. A New Way to Confirm Planet Candidates

    Science.gov (United States)

    Kohler, Susanna

    2016-05-01

    What was the big deal behind the Kepler news conference yesterday? Its not just that the number of confirmed planets found by Kepler has more than doubled (though thats certainly exciting news!). Whats especially interesting is the way in which these new planets were confirmed.Number of planet discoveries by year since 1995, including previous non-Kepler discoveries (blue), previous Kepler discoveries (light blue) and the newly validated Kepler planets (orange). [NASA Ames/W. Stenzel; Princeton University/T. Morton]No Need for Follow-UpBefore Kepler, the way we confirmed planet candidates was with follow-up observations. The candidate could be validated either by directly imaging (which is rare) or obtaining a large number radial-velocity measurements of the wobble of the planets host star due to the planets orbit. But once Kepler started producing planet candidates, these approaches to validation became less feasible. A lot of Kepler candidates are small and orbit faint stars, making follow-up observations difficult or impossible.This problem is what inspired the development of whats known as probabilistic validation, an analysis technique that involves assessing the likelihood that the candidates signal is caused by various false-positive scenarios. Using this technique allows astronomers to estimate the likelihood of a candidate signal being a true planet detection; if that likelihood is high enough, the planet candidate can be confirmed without the need for follow-up observations.A breakdown of the catalog of Kepler Objects of Interest. Just over half had previously been identified as false positives or confirmed as candidates. 1284 are newly validated, and another 455 have FPP of1090%. [Morton et al. 2016]Probabilistic validation has been used in the past to confirm individual planet candidates in Kepler data, but now Timothy Morton (Princeton University) and collaborators have taken this to a new level: they developed the first code thats designed to do fully

  8. Safety assessment document for the Dynamic Test Complex B854

    International Nuclear Information System (INIS)

    Odell, B.N.; Pfeifer, H.E.

    1981-01-01

    A safety assessment was performed to determine if potential accidents at the 854 Complex at Site 300 could present undue hazards to the general public, personnel at Site 300, or have an adverse effect on the environment. The credible accidents that might have an effect on these facilities or have off-site consequences were considered. These were earthquake, extreme wind (including missiles), lightning, flood, criticality, high explosive (HE) detonation that disperses uranium and beryllium, spontaneous oxidation of plutonium, explosions due to finely divided particles, and a fire. Seismic and extreme wind (including missiles) analyses indicate that the buildings are basically sound. The lightning protection system is in the process of being upgraded to meet AMCR 385-100. These buildings are located high above the dry creek bed so that a flood is improbable. The probability of high explosive detonation involving plutonium is very remote since the radioactive materials are encased and plutonium and HE are not permitted concurrently in the same area at Site 300. (The exception to this policy is that explosive actuating devices are sometimes located in assemblies containing fissile materials. However, an accidental actuation will not affect the safe containment of the plutonium within the assembly.) There is a remote possibility of an HE explosion involving uranium and beryllium since these are permitted in the same area.The possibility of a criticality accident is very remote since the fissile materials are doubly encased in stout metal containers. All operations involving these materials are independently reviewed and inspected by the Criticality Safety Office. It was determined that a fire was unlikely due to the low fire loading and the absence of ignition sources. It was also determined that the consequences of any accidents were reduced by the remote location of these facilities, their design, and by administrative controls

  9. Recent progress in safety assessments of Japanese water cooled solid breeder test blanket module

    International Nuclear Information System (INIS)

    Tsuru, Daigo; Enoeda, Mikio; Akiba, Masato

    2007-01-01

    Water Cooled Solid Breeder Test Blanket Module (WCSB TBM) is being designed by JAEA for the primary candidate TBM of Japan, and the safety evaluation of WCSB TBM has been performed. This reports presents summary of safety evaluation activities of the Japanese WCSB TBM, including nuclear analysis, source of RI, waste evaluation, occupational radiolysis exposure (ORE), failure mode effect analysis (FMEA) and postulated initiating event (PIE). For the purpose of basic evaluation of source terms on nuclear heating and radioactivity generation, two-dimensional nuclear analysis has been carried out. By the nuclear analysis, distributions of neutron flux, tritium breeding ratio (TBR), nuclear heat, decay heat and induced activity are calculated. Tritium production is calculated by the nuclear analysis by integrating distributions of TBR values, as about 0.2 g-T/FPD. With respect to the radioactive waste, the induced activity of the irradiated TBM is estimated. For the purpose of occupational radiolysis exposure (ORE), RI inventory is estimated. Tritium inventory in pebble bed of TBM is about 3 x 10 12 Bq, and tritium in purge gas is about 3 x 10 11 Bq. FMEA has been carried out to identify the PIEs that need safety evaluation. PIEs are summarized into three groups, i.e., heating, pressurization and release of RI. PIEs of local heating are converged without any special cares. With respect to heating of whole module, two PIEs are selected as the most severe events, i.e., loss of cooling of TBM during plasma operation and ingress of coolant into TBM during plasma operation. With respect to PIEs about pressurization, the PIEs of pressurization of the compartment nearby the pipes of cooling system are evaluated, because rupture of the pipes result pressurization of such compartments, i.e., box structure of TBM, purge gas loop, TRS, VV, port cell and TCWS vault. Box structure of TBM is designed to withstand the maximum pressure of the cooling system. At other compartments

  10. Assessment of strength characteristics of Al2024 ECAP metal using small punch testing

    International Nuclear Information System (INIS)

    Ma, Young Wha; Choi, Jeong Woo; Yoon, Kee Bong; Kim, Seon Hwa

    2006-01-01

    When subjected to severe shear deformation by ECAP, microstructure of Al2024 becomes extremely refined. To measure the strength of that, Small Punch(SP) testing method was adopted as a substitute for the conventional uniaxial tensile testing because the size of material processed by ECAP were limited to ψ12 mm in transverse direction. SP tests were performed with specimens in longitudinal and transverse directions of Al2024 ECAP metal. For comparing the strength values with those assessed by SP tests, uniaxial tensile tests were also conducted with specimens in longitudinal direction. Failure surfaces of the tested SP specimens showed that failure mode was shear deformation and Al2024 ECAP metal has an anisotropy in strength. Thus, conventional equations proposed for assessing the strength characteristics were improper to assess those of Al2024 ECAP metal. In this paper a way of assessing the strength of Al2024 ECAP metal was proposed and was proven to be effective

  11. Puzzle test: A tool for non-analytical clinical reasoning assessment.

    Science.gov (United States)

    Monajemi, Alireza; Yaghmaei, Minoo

    2016-01-01

    Most contemporary clinical reasoning tests typically assess non-automatic thinking. Therefore, a test is needed to measure automatic reasoning or pattern recognition, which has been largely neglected in clinical reasoning tests. The Puzzle Test (PT) is dedicated to assess automatic clinical reasoning in routine situations. This test has been introduced first in 2009 by Monajemi et al in the Olympiad for Medical Sciences Students.PT is an item format that has gained acceptance in medical education, but no detailed guidelines exist for this test's format, construction and scoring. In this article, a format is described and the steps to prepare and administer valid and reliable PTs are presented. PT examines a specific clinical reasoning task: Pattern recognition. PT does not replace other clinical reasoning assessment tools. However, it complements them in strategies for assessing comprehensive clinical reasoning.

  12. MOODLE XML TO IMS QTI ASSESSMENT TEST PORTABILITY ON LEARNING MANAGEMENT SYSTEM

    OpenAIRE

    Kautsar, Irwan Alnarus; Kubota, Shin-Ichiro; Musashi, Yasuo; Sugitani, Kenichi

    2013-01-01

    Learning Management Systems (i.e. LMS) is one of the most popular solutions towards the e-Learning objective in different universities all around the world, where this environments are used to not only deliver contents but to perform assessments, tests and other tasks related to learning. Although, there are popular LMS such as Moodle, and more developed, such as Chamilo, there is no assessment/test portability among their LMS. Each assessment export formats make difficult to transfer well do...

  13. 76 FR 81467 - Availability of an Environmental Assessment for Field Testing Swine Influenza Vaccine, RNA

    Science.gov (United States)

    2011-12-28

    ...] Availability of an Environmental Assessment for Field Testing Swine Influenza Vaccine, RNA AGENCY: Animal and... Vaccine, RNA. The environmental assessment, which is based on a risk analysis prepared to assess the risks...: Send your comment to Docket No. APHIS-2011-0114, Regulatory Analysis and Development, PPD, APHIS...

  14. Using slides to test for changes in crown defoliation assessment methods. Part I: Visual assessment of slides.

    Science.gov (United States)

    Dobbertin, Matthias; Hug, Christian; Mizoue, Nobuya

    2004-11-01

    In this study we used photographs of tree crowns to test whether the assessment methods for tree defoliation in Switzerland have changed over time. We randomly selected 24 series of slides of Norway spruce with field assessments made between 1986 and 1995. The slides were randomly arranged and assessed by three experts without prior knowledge of the year when the slide was taken or the tree number. Defoliation was assessed using the Swiss reference photo guide. Although the correlations between the field assessments and slide assessments were high (Spearman's rank correlation coefficient ranged between 0.79 and 0.83), we found significant differences between field and slide assessments (4.3 to 9% underprediction by the slide assessors) and between the slide assessments. However, no significant trends in field assessment methods could be detected. When the mean differences between field and slide assessments were subtracted, in some years, field assessors consistently underpredicted (1990, 1992) or overpredicted defoliation (1987, 1991). Defoliation tended to be overpredicted in slides taken against the light, and underpredicted for trees with more than 25% crown overlap. We conclude that slide series can be used to detect changes in assessment methods. However, potential observer bias calls for more objective methods of assessment.

  15. Explanatory item response modelling of an abstract reasoning assessment: A case for modern test design

    OpenAIRE

    Helland, Fredrik

    2016-01-01

    Assessment is an integral part of society and education, and for this reason it is important to know what you measure. This thesis is about explanatory item response modelling of an abstract reasoning assessment, with the objective to create a modern test design framework for automatic generation of valid and precalibrated items of abstract reasoning. Modern test design aims to strengthen the connections between the different components of a test, with a stress on strong theory, systematic it...

  16. Nigeria; Publication of Financial Sector Assessment Program Documentation––Technical Note on Stress Testing

    OpenAIRE

    International Monetary Fund

    2013-01-01

    To assess the financial stability in Nigeria, various stress tests and analytic processes were undertaken jointly by the Nigerian authorities and the Financial Sector Assessment Program (FSAP) team. The exercise included macroeconomic scenario analysis and its transmission into a range of single- and multifactor shocks. The tests covered the entire Nigerian banking system and looked at the short-term horizon, in part because of data constraints. Sensitivity stress tests estimated the impact o...

  17. Application and sensitivity testing of a eutrophication assessment method on coastal systems in the United States and European Union.

    Science.gov (United States)

    Ferreira, João Gomes; Bricker, Suzanne B; Simas, Teresa Castro

    2007-03-01

    The Assessment of Estuarine Trophic Status (ASSETS) screening model has been extended to allow its application to both estuarine and coastal systems. The model, which combines elements of pressure, state and response, was tested on four systems: Maryland Coastal Bays and Long Island Sound in the United States and The Firth of Clyde (Scotland) and Tagus Estuary (Portugal) in the European Union. The overall scores were: Maryland Coastal Bays: Bad; Firth of Clyde: Poor; Tagus Estuary: Good. Long Island Sound was modelled along a timeline, using 1991 data (score: Bad) and 2002 data (score: Moderate). The improvement registered for Long Island Sound is a consequence of the reduction in nutrient loading, and the ASSETS score changed accordingly. The two main areas where developments are needed are (a) In the definition of type-specific ranges for eutrophication parameters, due to the recognition that natural or pristine conditions may vary widely, and the use of a uniform set of thresholds artificially penalizes some systems and potentially leads to misclassification; (b) In the definition and quantification of measures which will result in an improved state through a change in pressures, as well as in the definition of appropriate metrics through which response may be assessed. One possibility is the use of detailed research models where different response scenarios potentially produce changes in pressure and state. These outputs may be used to drive screening models and analyze the suitability of candidate metrics for evaluating management options.

  18. Integrating Data-Based Decision Making, Assessment for Learning and Diagnostic Testing in Formative Assessment

    Science.gov (United States)

    Van der Kleij, Fabienne M.; Vermeulen, Jorine A.; Schildkamp, Kim; Eggen, Theo J. H .M.

    2015-01-01

    Recent research has highlighted the lack of a uniform definition of formative assessment, although its effectiveness is widely acknowledged. This paper addresses the theoretical differences and similarities amongst three approaches to formative assessment that are currently most frequently discussed in educational research literature: data-based…

  19. The Sympathetic Release Test: A Test Used to Assess Thermoregulation and Autonomic Control of Blood Flow

    Science.gov (United States)

    Tansey, E. A.; Roe, S. M.; Johnson, C. J.

    2014-01-01

    When a subject is heated, the stimulation of temperature-sensitive nerve endings in the skin, and the raising of the central body temperature, results in the reflex release of sympathetic vasoconstrictor tone in the skin of the extremities, causing a measurable temperature increase at the site of release. In the sympathetic release test, the…

  20. Assessment of Feasibility of Suction Pile/Anchor Installation and Pullout Testing through Field Tests

    Directory of Open Access Journals (Sweden)

    R. Vijaya

    2014-09-01

    Full Text Available Suction pile anchors are large cylindrical (inverted bucket type structure open at the bottom and closed at the top and largely used for mooring of offshore platforms, exploratory vessels etc. Prediction of the mooring capacity of suction piles is a critical issue faced by the design engineers and rational methods are required to produce reliable designs. Tests have been conducted in an existing natural pond within NIOT campus with the objective of developing methodology of deployment, design and logistics for suction pile installation and testing of mooring capacity under static pullout. Small size suction piles with varying diameters and lengths have been used in the tests. The tests have been carried out in the natural pond with constant water depth of 1.5 m with the top 1.5 m layer of bed comprising soft marine clay. It is found that pile geometry, aspect ratio and angle of pullout have a significant influence on the response to pullout. As angle of mooring load application changes from vertical to horizontal the reaction offered by the suction pile changes from skin friction to passive soil resistance. Resistance offered by the internal plug of soil is found to vary according to dimension of the anchor piles.

  1. Drill Sergeant Candidate Transformation

    Science.gov (United States)

    2009-02-01

    leadership styles of NCOs entering Drill Sergeant School (DSS). ARI also developed and administered a prototype DS Assessment Battery to assess...preferred leadership styles . DSS training increases both the degree to which the DSC feels obligated to and identifies with the Army. DSS training...4 TABLE 3. PREFERRED LEADERSHIP STYLES DEFINITIONS .............................................6 TABLE 4. DSC CHANGE IN

  2. A creep life assessment method for boiler pipes using small punch creep test

    International Nuclear Information System (INIS)

    Izaki, Toru; Kobayashi, Toshimi; Kusumoto, Junichi; Kanaya, Akihiro

    2009-01-01

    The small punch creep (SPC) test is considered as a highly useful method for creep life assessment for high temperature plant components. SPC uses miniature-sized specimens and does not cause any serious sampling damages, and its assessment accuracy is at a high level. However, in applying the SPC test to the residual creep life assessment of the boiler in service, there are some issues to be studied. In order to apply SPC test to the residual creep life assessment of the 2.25Cr-1Mo steel boiler pipe, the relationship between uniaxial creep stress and the SPC test load has been studied. The virgin material, pre-crept, weldment and service aged samples of 2.25Cr-1Mo steel were tested. It was confirmed that the relationship between uniaxial creep stress and the SPC test load at the same rupture time can be described as a single straight line independent of test conditions and materials. Therefore a life assessment is possible by using SPC test in place of uniaxial creep tests. The creep life assessment using SPC was applied to actual thermal power plant components which are in service.

  3. The Politics of Testing/Assessment (Or a Chameleon in the Classroom).

    Science.gov (United States)

    Lewis, Anne E.

    A number of political issues are involved in educational testing and the National Assessment of Educational Progress (NAEP). Many school officials are disturbed by the number of tests administered and the information and instructional time lost; they are reluctant to accede to further voluntary testing programs which might duplicate current…

  4. Promising new vaccine candidates against Campylobacter in broilers.

    Directory of Open Access Journals (Sweden)

    Marine Meunier

    Full Text Available Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the incidence of human diseases. At the primary production level, several measures have been identified to reach this goal, including vaccination of poultry. Despite many studies, however, no efficient vaccine is currently available. We have recently identified new vaccine candidates using the reverse vaccinology strategy. This study assessed the in vivo immune and protective potential of six newly-identified vaccine antigens. Among the candidates tested on Ross broiler chickens, four (YP_001000437.1, YP_001000562.1, YP_999817.1, and YP_999838.1 significantly reduced cecal Campylobacter loads by between 2 and 4.2 log10 CFU/g, with the concomitant development of a specific humoral immune response. In a second trial, cecal load reductions results were not statistically confirmed despite the induction of a strong immune response. These vaccine candidates need to be further investigated since they present promising features.

  5. Higher quality of molecular testing, an unfulfilled priority: Results from external quality assessment for KRAS mutation testing in colorectal cancer.

    Science.gov (United States)

    Tembuyser, Lien; Ligtenberg, Marjolijn J L; Normanno, Nicola; Delen, Sofie; van Krieken, J Han; Dequeker, Elisabeth M C

    2014-05-01

    Precision medicine is now a key element in clinical oncology. RAS mutational status is a crucial predictor of responsiveness to anti-epidermal growth factor receptor agents in metastatic colorectal cancer. In an effort to guarantee high-quality testing services in molecular pathology, the European Society of Pathology has been organizing an annual KRAS external quality assessment program since 2009. In 2012, 10 formalin-fixed, paraffin-embedded samples, of which 8 from invasive metastatic colorectal cancer tissue and 2 artificial samples of cell line material, were sent to more than 100 laboratories from 26 countries with a request for routine KRAS testing. Both genotyping and clinical reports were assessed independently. Twenty-seven percent of the participants genotyped at least 1 of 10 samples incorrectly. In total, less than 5% of the distributed specimens were genotyped incorrectly. Genotyping errors consisted of false negatives, false positives, and incorrectly genotyped mutations. Twenty percent of the laboratories reported a technical error for one or more samples. A review of the written reports showed that several essential elements were missing, most notably a clinical interpretation of the test result, the method sensitivity, and the use of a reference sequence. External quality assessment serves as a valuable educational tool in assessing and improving molecular testing quality and is an important asset for monitoring quality assurance upon incorporation of new biomarkers in diagnostic services. Copyright © 2014 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  6. Open-book tests to complement assessment-programmes : Analysis of open and closed-book tests

    NARCIS (Netherlands)

    Heijne-Penninga, M.; Kuks, J. B. M.; Schonrock-Adema, J.; Snijders, T. A. B.; Cohen-Schotanus, J.

    Today's health sciences educational programmes have to deal with a growing and changing amount of knowledge. It is becoming increasingly important for students to be able to use and manage knowledge. We suggest incorporating open-book tests in assessment programmes to meet these changes. This view

  7. A comparison of the efficacy of test-driven learning versus self-assessment learning

    Science.gov (United States)

    He, Xiaohua; Canty, Anne

    2013-01-01

    Objective We compared self-assessment and test-driven learning in two groups of students who studied the same subject. Methods This was a randomized comparative experimental study. The subjects were 259 first-quarter students who were divided into a test group and a self-assessment group based on the methods they used for their learning assessments. We measured the scores and difficulty levels of 3 formal written exams. Students' attitudes toward self-assessment or test-driven learning were surveyed. Results The mean scores of exam 1, exam 2, and a summative exam were 34 (±6), 32 (±8), and 44 (±6) for the self-assessment group, respectively, with corresponding scores of 33 (±6), 33 (±7), 43 (±6) for the test group. There were no significant differences in the mean scores on all 3 tests between the two groups (p > .05). Of the students in the self-assessment group, 64% scored at least 90%, whereas 47% of students in the test group answered at least 90% of the questions correctly (p self-assessment and tests could have a significant impact on students' learning, but each offers different strengths and weaknesses. PMID:23957317

  8. Comparison between Standing Broad Jump test and Wingate test for assessing lower limb anaerobic power in elite sportsmen.

    Science.gov (United States)

    Krishnan, Anup; Sharma, Deep; Bhatt, Madhu; Dixit, Apoorv; Pradeep, P

    2017-04-01

    Lower limb explosive power is an important motor quality for sporting performance and indicates use of anaerobic energy systems like stored ATP and Creatine phosphate system. Weightlifting, Fencing and Wrestling use it for monitoring and identification of potential sportsmen. The Wingate test and Standing Broad Jump (SBJ) test are reliable and accurate tests for its assessment. This study conducted on elite Indian sportsmen tries to analyse feasibility of use of the SBJ test in sports and military medicine when Wingate test is impractical. 95 elite sportsmen (51 Fencers, 17 Weight lifters and 27 Wrestlers) of a sports institute were administered Wingate cycle ergometer test and SBJ under standardised conditions. The results were analysed for mass and inter-discipline correlation. Analysis using Pearson's correlation showed significant positive correlation between Peak power ( r  = 0.446, p  Weightlifters. Bland-Altman plot analysis showed that about 94% pairs of peak power and SBJ were within limits of agreement for each discipline as well as among all sportsmen. The test results show definite correlation and SBJ test can be used as a field test in performance monitoring, talent identification, military recruit screening and injury prevention.

  9. Practice effects and test-re-test reliability of the Five Digit Test in patients with stroke over four serial assessments.

    Science.gov (United States)

    Chiu, En-Chi; Koh, Chia-Lin; Tsai, Chia-Yin; Lu, Wen-Shian; Sheu, Ching-Fan; Hsueh, I-Ping; Hsieh, Ching-Lin

    2014-01-01

    To investigate practice effect and test-re-test reliability of the Five Digit Test (FDT) over four serial assessments in patients with stroke. Single-group repeated measures design. Twenty-five patients with stroke were administered the FDT in four consecutive assessments every 2 weeks. The FDT contains four parts with five indices: 'basic measures of attention and processing speed', 'selective attention', 'alternating attention', 'ability of inhibition' and 'ability of switching'. The five indices of the FDT showed trivial-to-small practice effects (Cohen's d = 0.03-0.47) and moderate-to-excellent test-re-test reliability (intra-class correlation coefficient = 0.59-0.97). Practice effects of the five indices all appeared cumulative, but one index, 'basic measures of attention and processing speed', reached a plateau after the second assessment. The minimum and maximum values of the 90% confidence interval (CI) of reliable change index modified for practice (RCIp) for this index were [-17.6, 11.2]. One of five indices of the FDT reached a plateau, whose minimum and maximum values of the 90% CI RCIp are useful to determine whether the change in an individual's score is real. However, clinicians and researchers should be cautious when interpreting the test results of these four indices over repeated assessments.

  10. THEORY AND PRACTICE OF DESIGNING COURSES ON LANGUAGE TESTING AND ASSESSMENT

    Directory of Open Access Journals (Sweden)

    Olha Kvasova

    2016-12-01

    Full Text Available The paper considers the theoretical underpinnings and practices of designing courses on language testing and assessment for pre-service FL teacher training. The author analyses definitions of assessment literacy offered in the studies of world experts including teaching content and objectives of such long implemented courses. She further reasons the urgent need in introducing courses on language testing and assessment in Ukrainian universities; specifies the goal of the courses which lies in training student teachers in developing quality tests and administering assessments on the outset of their teaching career; outlines the content area to be covered in the course placing emphasis on its being based on professional needs; specifies course objectives such as building students’ awareness of key concepts and principles of language testing, developing ability to critically analyze available ready-made tests and make decisions about their fitting particular assessment needs, building skills to develop own or adapt ready-made tests and tailor them to the educational context; discusses preconditions of efficient running and attaining good outcomes of such courses which, in her view, are predetermined by traditionally high standards of teaching language pedagogy in Ukraine. An innovative structure of the course based on principles of testing cycle as well as interactive and constructivist methods of teaching language testing and assessment to student teachers are offered in the article.

  11. The most frequently used tests for assessing executive functions in aging

    Directory of Open Access Journals (Sweden)

    Camila de Assis Faria

    Full Text Available There are numerous neuropsychological tests for assessing executive functions in aging, which vary according to the different domains assessed. OBJECTIVE: To present a systematic review of the most frequently used instruments for assessing executive functions in older adults with different educational levels in clinical and experimental research. METHODS: We searched for articles published in the last five years, using the PubMed database with the following terms: "neuropsychological tests", "executive functions", and "mild cognitive impairment". There was no language restriction. RESULTS: 25 articles fulfilled all the inclusion criteria. The seven neuropsychological tests most frequently used to evaluate executive functions in aging were: [1] Trail Making Test (TMT Form B; [2] Verbal Fluency Test (VFT - F, A and S; [3] VFT Animals category; [4] Clock Drawing Test (CDT; [5] Digits Forward and Backward subtests (WAIS-R or WAIS-III; [6] Stroop Test; and [7] Wisconsin Card Sorting Test (WCST and its variants. The domains of executive functions most frequently assessed were: mental flexibility, verbal fluency, planning, working memory, and inhibitory control. CONCLUSION: The study identified the tests and domains of executive functions most frequently used in the last five years by research groups worldwide to evaluate older adults. These results can direct future research and help build evaluation protocols for assessing executive functions, taking into account the different educational levels and socio-demographic profiles of older adults in Brazil.

  12. Use of combined destructive and non-destructive test methods to assess the strength of concrete

    Energy Technology Data Exchange (ETDEWEB)

    Arioz, O. [Optimizing Consultancy, Izmir (Turkey); Kilinc, K. [Kirklareli University, Department of Civil Engineering, Kirklareli (Turkey); Ramyar, K. [Ege University, Department of Civil Engineering, Ismir (Turkey); Tuncan, M.; Tuncan, A. [Anadolu University, Department of Civil Engineering, Eskişehir (Turkey)

    2013-07-01

    The compressive strength test applied on standard samples is one of the most important tests indicating the quality of concrete in structures. The results of the standard tests are compared with the values used in design calculations and the quality of concrete is controlled. Although the standard tests are well accepted by the construction industry, they may not represent the in-situ strength of concrete due to the differences between the degree of compaction and curing conditions of concrete and those of standard samples. In-situ strength is also important for the efficient planning of the construction works in huge projects. In the present study, the results obtained from standard tests, core tests, ultrasonic pulse velocity tests, and rebound hammer tests were extensively analysed for the assessment of concrete strength. Key words: Concrete strength, standard tests, core test, ultrasonic pulse velocity, rebound number.

  13. Assessment of CPA Candidates' Education: Part Two

    Science.gov (United States)

    Giffin, Richard B.; Geddie, Mary; Moser, Ernest; Griffin, B. Wynne

    2012-01-01

    This paper is the second of a two part study comparing The Sixth Edition of the Uniform Accountancy Act as prepared and adopted by the National Association of State Boards of Accountancy (NASBA)with the actual regulatory practice of the various jurisdictional boards of accountancy in place just prior to the release of the most recent NASBA…

  14. An immunologic model for rapid vaccine assessment -- a clinical trial in a test tube.

    Science.gov (United States)

    Higbee, Russell G; Byers, Anthony M; Dhir, Vipra; Drake, Donald; Fahlenkamp, Heather G; Gangur, Jyoti; Kachurin, Anatoly; Kachurina, Olga; Leistritz, Del; Ma, Yifan; Mehta, Riyaz; Mishkin, Eric; Moser, Janice; Mosquera, Luis; Nguyen, Mike; Parkhill, Robert; Pawar, Santosh; Poisson, Louis; Sanchez-Schmitz, Guzman; Schanen, Brian; Singh, Inderpal; Song, Haifeng; Tapia, Tenekua; Warren, William; Wittman, Vaughan

    2009-09-01

    While the duration and size of human clinical trials may be difficult to reduce, there are several parameters in pre-clinical vaccine development that may be possible to further optimise. By increasing the accuracy of the models used for pre-clinical vaccine testing, it should be possible to increase the probability that any particular vaccine candidate will be successful in human trials. In addition, an improved model will allow the collection of increasingly more-informative data in pre-clinical tests, thus aiding the rational design and formulation of candidates entered into clinical evaluation. An acceleration and increase in sophistication of pre-clinical vaccine development will thus require the advent of more physiologically-accurate models of the human immune system, coupled with substantial advances in the mechanistic understanding of vaccine efficacy, achieved by using this model. We believe the best viable option available is to use human cells and/or tissues in a functional in vitro model of human physiology. Not only will this more accurately model human diseases, it will also eliminate any ethical, moral and scientific issues involved with use of live humans and animals. An in vitro model, termed "MIMIC" (Modular IMmune In vitro Construct), was designed and developed to reflect the human immune system in a well-based format. The MIMIC System is a laboratory-based methodology that replicates the human immune system response. It is highly automated, and can be used to simulate a clinical trial for a diverse population, without putting human subjects at risk. The MIMIC System uses the circulating immune cells of individual donors to recapitulate each individual human immune response by maintaining the autonomy of the donor. Thus, an in vitro test system has been created that is functionally equivalent to the donor's own immune system and is designed to respond in a similar manner to the in vivo response. 2009 FRAME.

  15. Licensure tests for special education teachers: how well they assess knowledge of reading instruction and mathematics.

    Science.gov (United States)

    Stotsky, Sandra

    2009-01-01

    To determine the extent to which knowledge of evidence-based reading instruction and mathematics is assessed on licensure tests for prospective special education teachers, this study drew on information provided by Educational Testing Service (ETS), the American Board for Certification of Teacher Excellence, and National Evaluation Systems (now Evaluation Systems group of Pearson). It estimated the percentage of test items on phonemic awareness, phonics, and vocabulary knowledge and on mathematics content. It also analyzed descriptions of ETS's tests of "principles of teaching and learning." Findings imply that prospective special education teachers should be required to take both a dedicated test of evidence-based reading instructional knowledge, as in California, Massachusetts, and Virginia, and a test of mathematical knowledge, as in Massachusetts. States must design their own tests of teaching principles to assess knowledge of evidence-based educational theories.

  16. A New Generation of Leaching Tests – The Leaching Environmental Assessment Framework

    Science.gov (United States)

    Provides an overview of newly released leaching tests that provide a more accurate source term when estimating environmental release of metals and other constituents of potential concern (COPCs). The Leaching Environmental Assessment Framework (LEAF) methods have been (1) develo...

  17. Orthopaedic nurses' knowledge and interrater reliability of neurovascular assessments with 2-point discrimination test.

    Science.gov (United States)

    Turney, Jennifer; Raley Noble, Deana; Kim, Son Chae

    2013-01-01

    : This study was conducted to evaluate the effects of education on knowledge and interrater reliability of neurovascular assessments with 2-point discrimination (2-PD) test among pediatric orthopaedic nurses. : A pre- and posttest study was done among 60 nurses attending 2-hour educational sessions. Neurovascular assessments with 2-PD test were performed on 64 casted pediatric patients by the nurses and 5 nurse experts before and after the educational sessions. : The mean neurovascular assessment knowledge score was improved at posteducation compared with the preeducation (p < .001). The 2-PD test interrater reliability also improved from Cohen's kappa value of 0.24-0.48 at posteducation. : The 2-hour educational session may be effective in improving nurses' knowledge and the interrater reliability of neurovascular assessment with 2-PD test.

  18. Global optimization of maintenance and surveillance testing based on reliability and probabilistic safety assessment. Research project

    International Nuclear Information System (INIS)

    Martorell, S.; Serradell, V.; Munoz, A.; Sanchez, A.

    1997-01-01

    Background, objective, scope, detailed working plan and follow-up and final product of the project ''Global optimization of maintenance and surveillance testing based on reliability and probabilistic safety assessment'' are described

  19. Field assessment of soil structural quality - a development of the Peerlkamp test

    DEFF Research Database (Denmark)

    Ball, B C; Batey, T; Munkholm, Lars Juhl

    2007-01-01

    properties (bulk density, penetration resistance and porosity) and crop growth. Indicative thresholds of soil management are suggested. The assessment should be viewed as complementary to conventional laboratory assessments of soil structure. Visual soil structure assessment can indicate to the soil......Increased awareness of the role of soil structure in defining the physical fertility or quality of soil has led to the need for a simple assessment relevant to the environmental and economic sustainability of soil productivity. A test is required that is usable by farmer, consultant and researcher...... alike. Here an assessment of soil structure quality (Sq) is described which is based on a visual key linked to criteria chosen to be as objective as possible. The influences of operator, tillage and crop type on Sq value were tested. The test takes 5-15 min per location and enough replicates were...

  20. Usefulness of the jump-and-reach test in assessment of vertical jump performance.

    Science.gov (United States)

    Menzel, Hans-Joachim; Chagas, Mauro H; Szmuchrowski, Leszek A; Araujo, Silvia R; Campos, Carlos E; Giannetti, Marcus R

    2010-02-01

    The objective was to estimate the reliability and criterion-related validity of the Jump-and-Reach Test for the assessment of squat, countermovement, and drop jump performance of 32 male Brazilian professional volleyball players. Performance of squat, countermovement, and drop jumps with different dropping heights was assessed on the Jump-and-Reach Test and the measurement of flight time, then compared across different jump trials. The very high reliability coefficients of both assessment methods and the lower correlation coefficients between scores on the assessments indicate a very high consistency of each method but only moderate covariation, which means that they measure partly different items. As a consequence, the Jump-and-Reach Test has good ecological validity in situations when reaching height during the flight phase is critical for performance (e.g., basketball and volleyball) but only limited accuracy for the assessment of vertical impulse production with different jump techniques and conditions.

  1. Balance Assessment in Sports-Related Concussion: Evaluating Test-Retest Reliability of the Equilibrate System.

    Science.gov (United States)

    Odom, Mitchell J; Lee, Young M; Zuckerman, Scott L; Apple, Rachel P; Germanos, Theodore; Solomon, Gary S; Sills, Allen K

    2016-01-01

    This study evaluated the test-retest reliability of a novel computer-based, portable balance assessment tool, the Equilibrate System (ES), used to diagnose sports-related concussion. Twenty-seven students participated in ES testing consisting of three sessions over 4 weeks. The modified Balance Error Scoring System was performed. For each participant, test-retest reliability was established using the intraclass correlation coefficient (ICC). The ES test-retest reliability from baseline to week 2 produced an ICC value of 0.495 (95% CI, 0.123-0.745). Week 2 testing produced ICC values of 0.602 (95% CI, 0.279-0.803) and 0.610 (95% CI, 0.299-0.804), respectively. All other single measures test-retest reliability values produced poor ICC values. Same-day ES testing showed fair to good test-retest reliability while interweek measures displayed poor to fair test-retest reliability. Testing conditions should be controlled when using computerized balance assessment methods. ES testing should only be used as a part of a comprehensive assessment.

  2. Web tools for the prioritization of candidate disease genes.

    NARCIS (Netherlands)

    Oti, M.O.; Ballouz, S.; Wouters, M.A.

    2011-01-01

    Despite increasing sequencing capacity, genetic disease investigation still frequently results in the identification of loci containing multiple candidate disease genes that need to be tested for involvement in the disease. This process can be expedited by prioritizing the candidates prior to

  3. Finding of No Significant Impact and Environmental Assessment for Flight Test to the Edge of Space

    Science.gov (United States)

    2008-12-01

    Runway 22 or on Rogers Dry Lakebed at Edwards AFB. 17 On the basis of the findings of the Environmental Assessment, no significant impact to human...FLIGHT TEST CENTER Environmental Assessment for Flight Test to the Edge of Space Page 5-3 Bowles, A.E., S. Eckert, L . Starke, E. Berg, L . Wolski, and...Numbers. Anne Choate, Laura 20 Pederson , Jeremy Scharfenberg, Henry Farland. Washington, D.C. September. 21 Jeppesen Sanderson, Incorporated 22

  4. Seedling imaging analysis and traditional tests to assess okra seed vigor

    OpenAIRE

    Kikuti,Ana Lúcia Pereira; Marcos-Filho,Júlio

    2013-01-01

    Seed vigor testing is an important component of quality control programs adopted by seed industry. The software Seed Vigor Imaging System (SVIS) has been successfully used for seed vigor assessment in different species. The objective of this research was to verify the SVIS efficiency to assess okra seed vigor in comparison to other vigor tests used for this species. Five seed lots of 'Clemson Americano' and four of 'Santa Cruz' were submitted to germination (speed and percentage), cold germin...

  5. Development of an Agility Test for Badminton Players and Assessment of Its Validity and Test-Retest Reliability.

    Science.gov (United States)

    Loureiro, Luiz de França Bahia; de Freitas, Paulo Barbosa

    2016-04-01

    Badminton requires open and fast actions toward the shuttlecock, but there is no specific agility test for badminton players with specific movements. To develop an agility test that simultaneously assesses perception and motor capacity and examine the test's concurrent and construct validity and its test-retest reliability. The Badcamp agility test consists of running as fast as possible to 6 targets placed on the corners and middle points of a rectangular area (5.6 × 4.2 m) from the start position located in the center of it, following visual stimuli presented in a luminous panel. The authors recruited 43 badminton players (17-32 y old) to evaluate concurrent (with shuttle-run agility test--SRAT) and construct validity and test-retest reliability. Results revealed that Badcamp presents concurrent and construct validity, as its performance is strongly related to SRAT (ρ = 0.83, P < .001), with performance of experts being better than nonexpert players (P < .01). In addition, Badcamp is reliable, as no difference (P = .07) and a high intraclass correlation (ICC = .93) were found in the performance of the players on 2 different occasions. The findings indicate that Badcamp is an effective, valid, and reliable tool to measure agility, allowing coaches and athletic trainers to evaluate players' athletic condition and training effectiveness and possibly detect talented individuals in this sport.

  6. Modification of Harvard step-test for assessment of students’ with health problems functional potentials

    Directory of Open Access Journals (Sweden)

    E.N. Kopeikina

    2016-08-01

    Full Text Available Purpose: to substantiate, work out and experimentally prove modified test for assessment of students’ with health problems functional potentials. Material: in the research students and girl students of 18-20 years’ age (n=522 participated. According to the worked out modification of test during 30 seconds student ascended on bench (h=43 cm and descended from it. Then pulse was measured three times. In total the test took 4 minutes. Results: For working out the scale for interpretation of the received results we assessed new 30 seconds’ modification of Harvard step-test for validity. First, for this purpose all students fulfilled modified step-test. Then after full restoration (after 20 minutes they fulfilled its three minutes’ variant. Correlation analysis of the received results showed the presence of average correlation between two samples (r=0.64. Conclusions: application of this modified variant permits for pedagogues to completely assess functional potentials of students with heath problems.

  7. A street intercept survey to assess HIV-testing attitudes and behaviors.

    Science.gov (United States)

    Rotheram-Borus, M J; Mann, T; Newman, P A; Grusky, O; Frerichs, R R; Wight, R G; Kuklinski, M

    2001-06-01

    Nationally, it has been estimated that 44% of adults in the United States have been tested for HIV, with substantial individual and community-level variations in HIV-testing attitudes and behaviors. HIV-testing behaviors and intentions and attitudes toward HIV testing, particularly toward home tests, were assessed among 385 adults recruited in a street intercept survey from a gay-identified agency, a substance-abuse treatment program, and inner-city community venues (a shopping mall and community center). Across these Los Angeles sites, the proportion of persons reported being tested for HIV in their lifetime (77%) was higher than the national estimate. Gay-identified agency (88%) and substance-abuse treatment program participants (99%) were more likely to have been tested than were the community participants (67%). Participants from a gay-identified agency were more likely to have had an anonymous test (51%) than were those from a substance-abuse treatment program (25%) or community sites (24%). Attitudes toward HIV testing, including mail-in home-test kits and instant home tests, were very positive. Most participants were willing to pay about $20 for a home-test kit. Participants from the community sites (82%) and the substance-abuse treatment program participants (87%) endorsed notification of HIV status to health departments and sexual partners more than did participants from the gay identified agency (48%). The street intercept survey appears to be a quick and feasible method to assess HIV testing in urban areas.

  8. Applying computer adaptive testing to optimize online assessment of suicidal behavior: a simulation study.

    NARCIS (Netherlands)

    de Beurs, D.P.; de Vries, A.L.M.; de Groot, M.H.; de Keijser, J.; Kerkhof, A.J.F.M.

    2014-01-01

    Background: The Internet is used increasingly for both suicide research and prevention. To optimize online assessment of suicidal patients, there is a need for short, good-quality tools to assess elevated risk of future suicidal behavior. Computer adaptive testing (CAT) can be used to reduce

  9. A Test-Retest Analysis of the Vanderbilt Assessment for Leadership in Education in the USA

    Science.gov (United States)

    Minor, Elizabeth Covay; Porter, Andrew C.; Murphy, Joseph; Goldring, Ellen; Elliott, Stephen N.

    2017-01-01

    The Vanderbilt Assessment for Leadership in Education (VAL-ED) is a 360-degree learning-centered behaviors principal evaluation tool that includes ratings from the principal, supervisors, and teachers. The current study assesses the test-retest reliability of the VAL-ED for a sample of seven school districts as part of multiple validity and…

  10. A Classroom-Based Assessment Method to Test Speaking Skills in English for Specific Purposes

    Science.gov (United States)

    Alberola Colomar, María Pilar

    2014-01-01

    This article presents and analyses a classroom-based assessment method to test students' speaking skills in a variety of professional settings in tourism. The assessment system has been implemented in the Communication in English for Tourism course, as part of the Tourism Management degree programme, at Florida Universitaria (affiliated to the…

  11. 76 FR 3075 - Availability of an Environmental Assessment for Field Testing Feline Leukemia Vaccine, Live...

    Science.gov (United States)

    2011-01-19

    ...] Availability of an Environmental Assessment for Field Testing Feline Leukemia Vaccine, Live Canarypox Vector... Feline Leukemia Vaccine, Live Canarypox Vector. The environmental assessment, which is based on a risk... ADDRESSES above for a link to Regulations.gov ). Requester: Merial, Inc. Product: Feline Leukemia Vaccine...

  12. Verification of the analytical fracture assessments methods by a large scale pressure vessel test

    Energy Technology Data Exchange (ETDEWEB)

    Keinanen, H; Oberg, T; Rintamaa, R; Wallin, K

    1988-12-31

    This document deals with the use of fracture mechanics for the assessment of reactor pressure vessel. Tests have been carried out to verify the analytical fracture assessment methods. The analysis is focused on flaw dimensions and the scatter band of material characteristics. Results are provided and are compared to experimental ones. (TEC).

  13. Properties of the COPD assessment test in a cross-sectional European study

    NARCIS (Netherlands)

    Jones, P. W.; Brusselle, G.; Dal Negro, R. W.; Ferrer, M.; Kardos, P.; Levye, M. L.; Perez, T.; Cataluna, J. J. Soler; van der Molen, T.; Adamek, L.; Banik, N.

    A short, easy-to-use health status questionnaire is needed in the multidimensional assessment of chronic obstructive pulmonary disease (COPD) in routine practice. The performance of the eight-item COPD assessment test (CAT) was analysed in 1,817 patients from primary care in seven European

  14. The Impact of the 2004 Hurricanes on Florida Comprehensive Assessment Test Scores: Implications for School Counselors

    Science.gov (United States)

    Baggerly, Jennifer; Ferretti, Larissa K.

    2008-01-01

    What is the impact of natural disasters on students' statewide assessment scores? To answer this question, Florida Comprehensive Assessment Test (FCAT) scores of 55,881 students in grades 4 through 10 were analyzed to determine if there were significant decreases after the 2004 hurricanes. Results reveal that there was statistical but no practical…

  15. Assessment of Current Practice for Tank Testing of Small Marine Energy Devices

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter; Frigaard, Peter

    Discussion Report. Equitable Testing and Evaluation of Marine Energy Extraction Devices in terms of Performance, Cost and Environmental Impact. The report is a contribution by Aalborg University (AAU) to the deliverable on Assessment of current practice for tank testing of small marine energy...

  16. The Sally-Anne Test: An Interactional Analysis of a Dyadic Assessment

    Science.gov (United States)

    Korkiakangas, Terhi; Dindar, Katja; Laitila, Aarno; Kärnä, Eija

    2016-01-01

    Background: The Sally-Anne test has been extensively used to examine children's theory of mind understanding. Many task-related factors have been suggested to impact children's performance on this test. Yet little is known about the interactional aspects of such dyadic assessment situations that might contribute to the ways in which children…

  17. On pre-test sensitisation and peer assessment to enhance learning gain in science education

    NARCIS (Netherlands)

    Bos, Floor/Floris

    2009-01-01

    *The main part of this thesis focuses on designing, optimising, and studying the embedding of two types of interventions: pre-testing and peer assessment, both supported by or combined with ICT-tools. * Pre-test sensitisation is used intentionally to boost the learning gain of the main intervention,

  18. Assessment of Prospective Memory – a Validity Study of Memory for Intentions Screening Test

    NARCIS (Netherlands)

    Bezdicek, O.; Raskin, S.A.; Altgassen, A.M.; Ruzicka, E.

    2014-01-01

    Aim: The goal of the present study was to validate the Czech version of the Memory for Intentions (Screening) Test (MIST, 2010). We included standardized testing material, translation of administration and scoring, and assessment of normative data for the MIST in the Czech population. Introduction:

  19. Multilevel Assessment of the Predictive Validity of Teacher Made Tests in the Zimbabwean Primary Education Sector

    Science.gov (United States)

    Machingambi, Zadzisai

    2017-01-01

    The principal focus of this study was to undertake a multilevel assessment of the predictive validity of teacher made tests in the Zimbabwean primary education sector. A correlational research design was adopted for the study, mainly to allow for statistical treatment of data and subsequent classical hypotheses testing using the spearman's rho.…

  20. 76 FR 12932 - Availability of an Environmental Assessment for Field Testing Fowl Laryngotracheitis-Marek's...

    Science.gov (United States)

    2011-03-09

    ... Inspection Service (APHIS), as well as obtain APHIS' authorization to ship the product for field testing. To... Inspection Service [Docket No. APHIS-2011-0011] Availability of an Environmental Assessment for Field Testing... and Plant Health Inspection Service, USDA. ACTION: Notice. SUMMARY: We are advising the public that...

  1. A Short Test for the Assessment of Basic Knowledge in Psychology

    Science.gov (United States)

    Peter, Johannes; Leichner, Nikolas; Mayer, Anne-Kathrin; Krampen, Günter

    2015-01-01

    This paper reports the development of a fixed-choice test for the assessment of basic knowledge in psychology, for use with undergraduate as well as graduate students. Test content is selected based on a core concepts approach and includes a sample of concepts which are indexed most frequently in common introductory psychology textbooks. In a…

  2. Assessment of Nondeclarative Learning in Severe Alzheimer Dementia The Implicit Memory Test (IMT)

    NARCIS (Netherlands)

    Kessels, R.P.C.; Remmerswaal, M.; Wilson, B.A.

    2011-01-01

    Although patients with Alzheimer dementia (AD) have impaired explicit memory, more automatic, implicit aspects of learning and memory may be relatively preserved. However, neuropsychological tests for the assessment of implicit memory are lacking. This study examines a newly developed test, the

  3. Assessment of nondeclarative learning in severe Alzheimer dementia: the Implicit Memory Test (IMT)

    NARCIS (Netherlands)

    Kessels, R.P.C.; Remmerswaal, M.; Wilson, B.A.

    2011-01-01

    Although patients with Alzheimer dementia (AD) have impaired explicit memory, more automatic, implicit aspects of learning and memory may be relatively preserved. However, neuropsychological tests for the assessment of implicit memory are lacking. This study examines a newly developed test, the

  4. Assessment of Selective Attention with CSCWT (Computerized Stroop Color-Word Test) among Children and Adults

    Science.gov (United States)

    Afsaneh, Zarghi; Alireza, Zali; Mehdi, Tehranidost; Farzad, Ashrafi; Reza, Zarindast Mohammad; Mehdi, Moazzezi; Mojtaba, Khodadadi Seyed

    2012-01-01

    The SCWT (Stroop Color-Word Test) is a quick and frequently used measure for assessing selective attention and cognitive flexibility. This study determines age, sex and education level influence on attention and cognitive flexibility by CSCWT (Computerized Stroop Color-Word Test) among healthy Iranian children and adults. There were 78 healthy…

  5. A Particle Swarm Optimization Approach to Composing Serial Test Sheets for Multiple Assessment Criteria

    Science.gov (United States)

    Yin, Peng-Yeng; Chang, Kuang-Cheng; Hwang, Gwo-Jen; Hwang, Gwo-Haur; Chan, Ying

    2006-01-01

    To accurately analyze the problems of students in learning, the composed test sheets must meet multiple assessment criteria, such as the ratio of relevant concepts to be evaluated, the average discrimination degree, difficulty degree and estimated testing time. Furthermore, to precisely evaluate the improvement of student's learning performance…

  6. Self-Assessment, Preparation and Response Time on a Computerized Oral Proficiency Test

    Science.gov (United States)

    Malabonga, Valerie; Kenyon, Dorry M.; Carpenter, Helen

    2005-01-01

    Two studies investigated technical aspects of a computer-mediated test, the Computerized Oral Proficiency Instrument (COPI), particularly in contrast to a similar tape-mediated test, the Simulated Oral Proficiency Interview (SOPI). The first study investigated how examinees used self-assessment to choose an appropriate starting level on the COPI.…

  7. Assessment of performance of selected serological tests for diagnosing brucellosis in pigs.

    NARCIS (Netherlands)

    Munoz, P.M.; Blasco, J.M.; Engel, B.; Miguel, de M.J.; Marín, C.M.; Dieste, L.; Mainar-Jaime, R.C.

    2012-01-01

    Swine brucellosis due to Brucella suis is considered an emerging zoonotic disease whose control is based on serological testing and the subsequent culling of seropositive animals or the full depopulation of affected flocks. Here we assessed the performance of several serological tests (Rose Bengal

  8. The effect of a discrete signal on context conditioning: Assessment by preference and freezing tests

    NARCIS (Netherlands)

    Maes, J.H.R.; LoLordo, V.M.

    1996-01-01

    Four experiments with rats assessed conditioning to contextual cues after the delivery of footshocks that were either signaled by a discrete stimulus or unsignaled. Two different tests were used. The first was a context preference test in which subjects were allowed to move freely in a brightly lit,

  9. An Alternative Approach to Assessing Laboratory and Field Notebooks: The Data Retrieval Test

    Science.gov (United States)

    Bedford, Hilary; Bedford, Alan; Thomas, Judith; Ashton, Paul

    2010-01-01

    Marking field and laboratory notebooks can be a time consuming and tedious task. This article describes a system whereby the contents of student's notebooks are assessed by testing the students on what they have included and their understanding of what has been done. It also tests the quality of the student's notes--detailed, organised notes…

  10. Survey of total error of precipitation and homogeneous HDL-cholesterol methods and simultaneous evaluation of lyophilized saccharose-containing candidate reference materials for HDL-cholesterol

    NARCIS (Netherlands)

    C.M. Cobbaert (Christa); H. Baadenhuijsen; L. Zwang (Louwerens); C.W. Weykamp; P.N. Demacker; P.G.H. Mulder (Paul)

    1999-01-01

    textabstractBACKGROUND: Standardization of HDL-cholesterol is needed for risk assessment. We assessed for the first time the accuracy of HDL-cholesterol testing in The Netherlands and evaluated 11 candidate reference materials (CRMs). METHODS: The total error (TE) of

  11. Independent assessment of TRAC and RELAP5 codes through separate effects tests

    International Nuclear Information System (INIS)

    Saha, P.; Rohatgi, U.S.; Jo, J.H.; Neymotin, L.; Slovik, G.; Yuelys-Miksis, C.; Pu, J.

    1983-01-01

    Independent assessment of TRAC-PF1 (Version 7.0), TRAC-BD1 (Version 12.0) and RELAP5/MOD1 (Cycle 14) that was initiated at BNL in FY 1982, has been completed in FY 1983. As in the previous years, emphasis at Brookhaven has been in simulating various separate-effects tests with these advanced codes and identifying the areas where further thermal-hydraulic modeling improvements are needed. The following six catetories of tests were simulated with the above codes: (1) critical flow tests (Moby-Dick nitrogen-water, BNL flashing flow, Marviken Test 24); (2) Counter-Current Flow Limiting (CCFL) tests (University of Houston, Dartmouth College single and parallel tube test); (3) level swell tests (G.E. large vessel test); (4) steam generator tests (B and W 19-tube model S.G. tests, FLECHT-SEASET U-tube S.G. tests); (5) natural circulation tests (FRIGG loop tests); and (6) post-CHF tests (Oak Ridge steady-state test)

  12. Academic performance of ethnic minority candidates and discrimination in the MRCGP examinations between 2010 and 2012: analysis of data.

    Science.gov (United States)

    Esmail, Aneez; Roberts, Chris

    2013-09-26

    To determine the difference in failure rates in the postgraduate examination of the Royal College of General Practitioners (MRCGP) by ethnic or national background, and to identify factors associated with pass rates in the clinical skills assessment component of the examination. Analysis of data provided by the Royal College of General Practitioners and the General Medical Council. Cohort of 5095 candidates sitting the applied knowledge test and clinical skills assessment components of the MRCGP examination between November 2010 and November 2012. A further analysis was carried out on 1175 candidates not trained in the United Kingdom, who sat an English language capability test (IELTS) and the Professional and Linguistic Assessment Board (PLAB) examination (as required for full medical registration), controlling for scores on these examinations and relating them to pass rates of the clinical skills assessment. United Kingdom. After controlling for age, sex, and performance in the applied knowledge test, significant differences persisted between white UK graduates and other candidate groups. Black and minority ethnic graduates trained in the UK were more likely to fail the clinical skills assessment at their first attempt than their white UK colleagues (odds ratio 3.536 (95% confidence interval 2.701 to 4.629), PIELTS, and PLAB examinations (adjusted odds ratio 1.580 (95% confidence interval 0.878 to 2.845), P=0.127). Subjective bias due to racial discrimination in the clinical skills assessment may be a cause of failure for UK trained candidates and international medical graduates. The difference between British black and minority ethnic candidates and British white candidates in the pass rates of the clinical skills assessment, despite controlling for prior attainment, suggests that subjective bias could also be a factor. Changes to the clinical skills assessment could improve the perception of the examination as being biased against black and minority ethnic

  13. Wind Resource Assessment – Østerild National Test Centre for Large Wind Turbines

    OpenAIRE

    Hansen, Brian Ohrbeck; Courtney, Michael; Mortensen, Niels Gylling

    2014-01-01

    This report presents a wind resource assessment for the seven test stands at the Østerild National Test Centre for Large Wind Turbines in Denmark. Calculations have been carried out mainly using wind data from three on-site wind lidars. The generalized wind climates applied in the wind resource calculations for the seven test stands are based on correlations between a short period of on-site wind data from the wind lidars with a long-term reference. The wind resource assessment for the seven ...

  14. Assessment of three cuban sites for testing resistance to sugarcane mosaic virus

    Directory of Open Access Journals (Sweden)

    Yaquelin Puchades

    2015-03-01

    Full Text Available Sugarcane mosaic disease is amongst the world’s most important diseases affecting sugarcane worldwide. The objective was to assess the environmental conditions of the sites where the test for SCMV resistance is done. Multi-environment trial Data were analyzed using a Principal Components Analysis Eighteen sugarcane genotypes s were evaluated from the main testing sites in Cuba (Jovellanos, Florida, Mayarí . The information of the climatic conditions was recorded at local weather stations. The assessment of the sites was done by analyzing the main components. Results showed that the testing sites were different from one another, and proved that the environment strongly influences on the mosaic symptom manifestation. PCA was an excellent procedure to assess the testing sites .for SCMV resistance.

  15. Validity, Reliability and Standardization Study of the Language Assessment Test for Aphasia

    Directory of Open Access Journals (Sweden)

    Bülent Toğram

    2012-09-01

    Full Text Available OBJECTIVE: Aphasia assessment is the first step towards a well- founded language therapy. Language tests need to consider cultural as well as typological linguistic aspects of a given language. This study was designed to determine the standardization, validity and reliability of Language Assessment Test for Aphasia, which consists of eight subtests including spontaneous speech and language, auditory comprehension, repetition, naming, reading, grammar, speech acts, and writing. METHODS: The test was administered to 282 healthy participants and 92 aphasic participants in age, education and gender matched groups. The validity study of the test was investigated with analysis of content, structure and criterion-related validity. For reliability of the test, the analysis of internal consistency, stability and equivalence reliability was conducted. The influence of variables on healhty participants’ sub-test scores, test score and language score was examined. According to significant differences, norms and cut-off scores based on language score were determined. RESULTS: The group with aphasia performed highly lower than healthy participants on subtest, test and language scores. The test scores of healthy group were mostly affected by age and educational level but not affected by gender. According to significant differences, age and educational level for both groups were determined. Considering age and educational levels, the reference values for the cut-off scores were presented. CONCLUSION: The test was found to be a highly reliable and valid aphasia test for Turkish- speaking aphasic patients either in Turkey or other Turkish communities around the world

  16. Reliability of Arm Curl and Chair Stand tests for assessing muscular endurance in older people

    Directory of Open Access Journals (Sweden)

    Boneth M

    2012-05-01

    Full Text Available Objective: to assess the test-retest reliability and level of agreement between measures of the 30 second (30-s Arm Curl and 30-s Chair Stand test in a sample of older adults from Bucaramanga. Materials and methods: a study of evaluation of diagnostic technology was done. Both tests were administered by the same evaluator to 111 adults older than 59 year-old (70,4 ± 7,3, on two occasions, with an interval of time between measures of 4 to 8 days. In the analysis, test-retest reliability was determined using the Intraclass Correlation Coefficient ICC= 2,1 with their confidence interval 95% (CI 95% respective. The agreement level was established by the Bland and Altman method. Results: the test-retest reproducibility of the 30-s Arm Curl test was very good ICC= 0,88 and to the Chair Stand test was good ICC= 0,78. The agreement was very good for both tests of muscle endurance. The CI 95% were between -3,8 and 3,2 stands to 30-s Chair Stand test and between -3,1 and 2,8 curls to 30-s Arm Curl test. Conclusion: the 30-s Arm Curl and 30-s Chair Stand test have good reliability and agreement to assess muscle endurance in older adults functionally independent.

  17. Plant Disease Severity Assessment-How Rater Bias, Assessment Method, and Experimental Design Affect Hypothesis Testing and Resource Use Efficiency.

    Science.gov (United States)

    Chiang, Kuo-Szu; Bock, Clive H; Lee, I-Hsuan; El Jarroudi, Moussa; Delfosse, Philippe

    2016-12-01

    The effect of rater bias and assessment method on hypothesis testing was studied for representative experimental designs for plant disease assessment using balanced and unbalanced data sets. Data sets with the same number of replicate estimates for each of two treatments are termed "balanced" and those with unequal numbers of replicate estimates are termed "unbalanced". The three assessment methods considered were nearest percent estimates (NPEs), an amended 10% incremental scale, and the Horsfall-Barratt (H-B) scale. Estimates of severity of Septoria leaf blotch on leaves of winter wheat were used to develop distributions for a simulation model. The experimental designs are presented here in the context of simulation experiments which consider the optimal design for the number of specimens (individual units sampled) and the number of replicate estimates per specimen for a fixed total number of observations (total sample size for the treatments being compared). The criterion used to gauge each method was the power of the hypothesis test. As expected, at a given fixed number of observations, the balanced experimental designs invariably resulted in a higher power compared with the unbalanced designs at different disease severity means, mean differences, and variances. Based on these results, with unbiased estimates using NPE, the recommended number of replicate estimates taken per specimen is 2 (from a sample of specimens of at least 30), because this conserves resources. Furthermore, for biased estimates, an apparent difference in the power of the hypothesis test was observed between assessment methods and between experimental designs. Results indicated that, regardless of experimental design or rater bias, an amended 10% incremental scale has slightly less power compared with NPEs, and that the H-B scale is more likely than the others to cause a type II error. These results suggest that choice of assessment method, optimizing sample number and number of replicate

  18. Recent development in low-constraint fracture toughness testing for structural integrity assessment of pipelines

    Science.gov (United States)

    Kang, Jidong; Gianetto, James A.; Tyson, William R.

    2018-03-01

    Fracture toughness measurement is an integral part of structural integrity assessment of pipelines. Traditionally, a single-edge-notched bend (SE(B)) specimen with a deep crack is recommended in many existing pipeline structural integrity assessment procedures. Such a test provides high constraint and therefore conservative fracture toughness results. However, for girth welds in service, defects are usually subjected to primarily tensile loading where the constraint is usually much lower than in the three-point bend case. Moreover, there is increasing use of strain-based design of pipelines that allows applied strains above yield. Low-constraint toughness tests represent more realistic loading conditions for girth weld defects, and the corresponding increased toughness can minimize unnecessary conservatism in assessments. In this review, we present recent developments in low-constraint fracture toughness testing, specifically using single-edgenotched tension specimens, SENT or SE(T). We focus our review on the test procedure development and automation, round-robin test results and some common concerns such as the effect of crack tip, crack size monitoring techniques, and testing at low temperatures. Examples are also given of the integration of fracture toughness data from SE(T) tests into structural integrity assessment.

  19. A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment.

    Science.gov (United States)

    Scholz, Stefan; Sela, Erika; Blaha, Ludek; Braunbeck, Thomas; Galay-Burgos, Malyka; García-Franco, Mauricio; Guinea, Joaquin; Klüver, Nils; Schirmer, Kristin; Tanneberger, Katrin; Tobor-Kapłon, Marysia; Witters, Hilda; Belanger, Scott; Benfenati, Emilio; Creton, Stuart; Cronin, Mark T D; Eggen, Rik I L; Embry, Michelle; Ekman, Drew; Gourmelon, Anne; Halder, Marlies; Hardy, Barry; Hartung, Thomas; Hubesch, Bruno; Jungmann, Dirk; Lampi, Mark A; Lee, Lucy; Léonard, Marc; Küster, Eberhard; Lillicrap, Adam; Luckenbach, Till; Murk, Albertinka J; Navas, José M; Peijnenburg, Willie; Repetto, Guillermo; Salinas, Edward; Schüürmann, Gerrit; Spielmann, Horst; Tollefsen, Knut Erik; Walter-Rohde, Susanne; Whale, Graham; Wheeler, James R; Winter, Matthew J

    2013-12-01

    Tests with vertebrates are an integral part of environmental hazard identification and risk assessment of chemicals, plant protection products, pharmaceuticals, biocides, feed additives and effluents. These tests raise ethical and economic concerns and are considered as inappropriate for assessing all of the substances and effluents that require regulatory testing. Hence, there is a strong demand for replacement, reduction and refinement strategies and methods. However, until now alternative approaches have only rarely been used in regulatory settings. This review provides an overview on current regulations of chemicals and the requirements for animal tests in environmental hazard and risk assessment. It aims to highlight the potential areas for alternative approaches in environmental hazard identification and risk assessment. Perspectives and limitations of alternative approaches to animal tests using vertebrates in environmental toxicology, i.e. mainly fish and amphibians, are discussed. Free access to existing (proprietary) animal test data, availability of validated alternative methods and a practical implementation of conceptual approaches such as the Adverse Outcome Pathways and Integrated Testing Strategies were identified as major requirements towards the successful development and implementation of alternative approaches. Although this article focusses on European regulations, its considerations and conclusions are of global relevance. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Military Ecological Risk Assessment Framework (MERAF) for Assessment of Risks of Military Training and Testing to Natural Resources

    Energy Technology Data Exchange (ETDEWEB)

    Suter II, G.W.

    2003-06-18

    The objective of this research is to provide the DoD with a framework based on a systematic, risk-based approach to assess impacts for management of natural resources in an ecosystem context. This risk assessment framework is consistent with, but extends beyond, the EPA's ecological risk assessment framework, and specifically addresses DoD activities and management needs. MERAF is intended to be consistent with existing procedures for environmental assessment and planning with DoD testing and training. The intention is to supplement these procedures rather than creating new procedural requirements. MERAF is suitable for use for training and testing area assessment and management. It does not include human health risks nor does it address specific permitting or compliance requirements, although it may be useful in some of these cases. Use of MERAF fits into the National Environmental Policy Act (NEPA) process by providing a consistent and rigorous way of organizing and conducting the technical analysis for Environmental Impact Statements (EISs) (Sigal 1993; Carpenter 1995; Canter and Sadler 1997). It neither conflicts with, nor replaces, procedural requirements within the NEPA process or document management processes already in place within DoD.

  1. Gulf Coast Programmatic Environmental Assessment Geothermal Well Testing: The Frio Formation of Texas and Louisiana

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-10-01

    In accordance with the requirements of 10 CFR Part 711, environmental assessments are being prepared for significant activities and individual projects of the Division of Geothermal Energy (DGE) of the Energy Research and Development Administration (ERDA). This environmental assessment of geopressure well testing addresses, on a regional basis, the expected activities, affected environments, and possible impacts in a broad sense. The specific part of the program addressed by this environmental assessment is geothermal well testing by the take-over of one or more unsuccessful oil wells before the drilling rig is removed and completion of drilling into the geopressured zone. Along the Texas and Louisiana Gulf Coast (Plate 1 and Overlay) water at high temperatures and high pressures is trapped within Gulf basin sediments. The water is confined within or below essentially impermeable shale sequences and carries most or all of the overburden pressure. Such zones are referred to as geopressured strata. These fluids and sediments are heated to abnormally high temperatures (up to 260 C) and may provide potential reservoirs for economical production of geothermal energy. The obvious need in resource development is to assess the resource. Ongoing studies to define large-sand-volume reservoirs will ultimately define optimum sites for drilling special large diameter wells to perform large volume flow production tests. In the interim, existing well tests need to be made to help define and assess the resource. The project addressed by this environmental assessment is the performance of a geothermal well test in high potential geothermal areas. Well tests involve four major actions each of which may or may not be required for each of the well tests. The four major actions are: site preparation, drilling a salt-water disposal well, actual flow testing, and abandonment of the well.

  2. A study on assessment methodology of surveillance test interval and allowed outage time

    International Nuclear Information System (INIS)

    Che, Moo Seong; Cheong, Chang Hyeon; Lee, Byeong Cheol

    1996-07-01

    The objectives of this study is the development of methodology by which assessing the optimizes Surveillance Test Interval(STI) and Allowed Outage Time(AOT) using PSA method that can supplement the current deterministic methods and the improvement of Korea nuclear power plants safety. In the first year of this study, the survey about the assessment methodologies, modeling and results performed by domestic and international researches is performed as the basic step before developing the assessment methodology of this study. The assessment methodology that supplement the revealed problems in many other studies is presented and the application of new methodology into the example system assures the feasibility of this method

  3. A study on assessment methodology of surveillance test interval and allowed outage time

    Energy Technology Data Exchange (ETDEWEB)

    Che, Moo Seong; Cheong, Chang Hyeon; Lee, Byeong Cheol [Seoul Nationl Univ., Seoul (Korea, Republic of)] (and others)

    1996-07-15

    The objectives of this study is the development of methodology by which assessing the optimizes Surveillance Test Interval(STI) and Allowed Outage Time(AOT) using PSA method that can supplement the current deterministic methods and the improvement of Korea nuclear power plants safety. In the first year of this study, the survey about the assessment methodologies, modeling and results performed by domestic and international researches is performed as the basic step before developing the assessment methodology of this study. The assessment methodology that supplement the revealed problems in many other studies is presented and the application of new methodology into the example system assures the feasibility of this method.

  4. The Harvard Beat Assessment Test (H-BAT): a battery for assessing beat perception and production and their dissociation

    Science.gov (United States)

    Fujii, Shinya; Schlaug, Gottfried

    2013-01-01

    Humans have the abilities to perceive, produce, and synchronize with a musical beat, yet there are widespread individual differences. To investigate these abilities and to determine if a dissociation between beat perception and production exists, we developed the Harvard Beat Assessment Test (H-BAT), a new battery that assesses beat perception and production abilities. H-BAT consists of four subtests: (1) music tapping test (MTT), (2) beat saliency test (BST), (3) beat interval test (BIT), and (4) beat finding and interval test (BFIT). MTT measures the degree of tapping synchronization with the beat of music, whereas BST, BIT, and BFIT measure perception and production thresholds via psychophysical adaptive stair-case methods. We administered the H-BAT on thirty individuals and investigated the performance distribution across these individuals in each subtest. There was a wide distribution in individual abilities to tap in synchrony with the beat of music during the MTT. The degree of synchronization consistency was negatively correlated with thresholds in the BST, BIT, and BFIT: a lower degree of synchronization was associated with higher perception and production thresholds. H-BAT can be a useful tool in determining an individual's ability to perceive and produce a beat within a single session. PMID:24324421

  5. The Harvard Beat Assessment Test (H-BAT): a battery for assessing beat perception and production and their dissociation.

    Science.gov (United States)

    Fujii, Shinya; Schlaug, Gottfried

    2013-01-01

    Humans have the abilities to perceive, produce, and synchronize with a musical beat, yet there are widespread individual differences. To investigate these abilities and to determine if a dissociation between beat perception and production exists, we developed the Harvard Beat Assessment Test (H-BAT), a new battery that assesses beat perception and production abilities. H-BAT consists of four subtests: (1) music tapping test (MTT), (2) beat saliency test (BST), (3) beat interval test (BIT), and (4) beat finding and interval test (BFIT). MTT measures the degree of tapping synchronization with the beat of music, whereas BST, BIT, and BFIT measure perception and production thresholds via psychophysical adaptive stair-case methods. We administered the H-BAT on thirty individuals and investigated the performance distribution across these individuals in each subtest. There was a wide distribution in individual abilities to tap in synchrony with the beat of music during the MTT. The degree of synchronization consistency was negatively correlated with thresholds in the BST, BIT, and BFIT: a lower degree of synchronization was associated with higher perception and production thresholds. H-BAT can be a useful tool in determining an individual's ability to perceive and produce a beat within a single session.

  6. Determination of the number of software tests using probabilistic safety assessment

    International Nuclear Information System (INIS)

    Kang, H. K.; Seong, T. Y.; Lee, K. Y.

    2000-01-01

    The broader usage of digital equipment in nuclear power plants gives rise to the safety problems of software. The field test should be performed before the software is used in critical applications because it is well known that software shows non-linear response when it is applied to different target systems in different environment. In the case of safety-critical applications, the result of tests contains usually zero failure case and the satisfiable number of tests is hard to be determined. In this paper, we suggests the method to determine the number of software tests without failure using the probabilistic safety assessment. From the result of the probabilistic safety assessment on total system, the desirable unavailability of software is calculated and the number of tests is determined

  7. Sensitivity and specificity of the 3-item memory test in the assessment of post traumatic amnesia.

    Science.gov (United States)

    Andriessen, Teuntje M J C; de Jong, Ben; Jacobs, Bram; van der Werf, Sieberen P; Vos, Pieter E

    2009-04-01

    To investigate how the type of stimulus (pictures or words) and the method of reproduction (free recall or recognition after a short or a long delay) affect the sensitivity and specificity of a 3-item memory test in the assessment of post traumatic amnesia (PTA). Daily testing was performed in 64 consecutively admitted traumatic brain injured patients, 22 orthopedically injured patients and 26 healthy controls until criteria for resolution of PTA were reached. Subjects were randomly assigned to a test with visual or verbal stimuli. Short delay reproduction was tested after an interval of 3-5 minutes, long delay reproduction was tested after 24 hours. Sensitivity and specificity were calculated over the first 4 test days. The 3-word test showed higher sensitivity than the 3-picture test, while specificity of the two tests was equally high. Free recall was a more effortful task than recognition for both patients and controls. In patients, a longer delay between registration and recall resulted in a significant decrease in the number of items reproduced. Presence of PTA is best assessed with a memory test that incorporates the free recall of words after a long delay.

  8. The Timed 180° Turn Test for Assessing People with Hemiplegia from Chronic Stroke

    Directory of Open Access Journals (Sweden)

    Regan L. Robinson

    2018-01-01

    Full Text Available Background. Turning is ubiquitous in activities of daily living. For people with hemiplegia, persistent impairments in strength, balance, and coordination will affect their ability to turn safely. Consequently, turning retraining should be addressed in rehabilitation programs. To measure turning for these individuals, a reliable clinical tool is required. Objective. To investigate (i the intrarater, interrater, and test-retest reliability of the timed 180° turn test; (ii the correlation of the timed 180° turn test with other measures of stroke-specific impairments; and (iii the cut-off time that best discriminates individuals with hemiplegia from chronic stroke and healthy older adults. Methods. 33 individuals with hemiplegia due to chronic stroke and 32 healthy elderly individuals participated in this cross-sectional study. The timed 180° turn test was administered along with other measures of stroke-specific impairment. Results. The timed 180° turn test demonstrated excellent intrarater, interrater, and test-retest reliability in individuals with hemiplegia from chronic stroke. The timed 180° turn test (times significantly correlated with the Fugl-Meyer Assessment of the Lower Extremities (FMA-LE, affected ankle plantar flexion strength, the 5-Times-Sit-To-Stand test, the Berg Balance Scale (BBS, and the Timed Up and Go (TUG test. Conclusion. The timed 180° turn test is a reliable clinical tool to assess the turning ability of subjects with hemiplegia from chronic stroke.

  9. from microarrays and quantitative trait loci to candidate genes

    Indian Academy of Sciences (India)

    Unknown

    2004-10-15

    Oct 15, 2004 ... to candidate genes – A research plan and preliminary results using Drosophila as a model organism and climatic ... Recent developments in molecular genetics ..... scientists in agriculture, medicine and psychology for test-.

  10. How to assess the mutagenic potential of cosmetic products without animal tests?

    Science.gov (United States)

    Speit, Günter

    2009-08-01

    Animal experiments (in vivo tests) currently play a key role in genotoxicity testing. Results from in vivo tests are, in many cases, decisive for the assessment of a mutagenic potential of a test compound. The Seventh Amendment to the European Cosmetics Directive will, however, ban the European marketing of cosmetic/personal care products that contain ingredients that have been tested in animal experiments. If genotoxicity testing is solely based on the currently established in vitro tests, the attrition rate for chemicals used in cosmetic products will greatly increase due to irrelevant positive in vitro test results. There is urgent need for new and/or improved in vitro genotoxicity tests and for modified test strategies. Test strategies should consider all available information on chemistry of the test substance/the chemical class (e.g. SAR, metabolic activation and dermal adsorption). Test protocols for in vitro genotoxicity tests should be sensitive and robust enough to ensure that negative results can be accepted with confidence. It should be excluded that positive in vitro test results are due to high cytotoxicity or secondary genotoxic effects which may be thresholded and/or only occur under in vitro test conditions. Consequently, further research is needed to establish the nature of thresholds in in vitro assays and to determine the potential for incorporation of mode of action data into future risk assessments. New/improved tests have to be established and validated, considering the use of (metabolically competent) primary (skin) cells, 3D skin models and cells with defined capacity for metabolic activation (e.g. genetically engineered cell lines). The sensitivity and specificity of new and improved genotoxicity tests has to be determined by testing a battery of genotoxic and non-genotoxic chemicals. New or adapted international guidelines will be needed for these tests. The establishment of such a new genotoxicity testing strategy will take time and the

  11. The verification tests of residual radioactivity measurement and assessment techniques for buildings and soils

    International Nuclear Information System (INIS)

    Onozawa, T.; Ishikura, T.; Yoshimura, Yukio; Nakazawa, M.; Makino, S.; Urayama, K.; Kawasaki, S.

    1996-01-01

    According to the standard procedure for decommissioning a commercial nuclear power plant (CNPP) in Japan, controlled areas will be released for unrestricted use before the dismantling of a reactor building. If manual survey and sampling techniques were applied to measurement for unrestricted release on and in the extensive surface of the building, much time and much specialized labor would be required to assess the appropriateness of the releasing. Therefore the authors selected the following three techniques for demonstrating reliability and applicability of the techniques for CNPPs: (1) technique of assessing radioactive concentration distribution on the surface of buildings (ADB); (2) technique of assessing radioactive permeation distribution in the concrete structure of buildings (APB); (3) technique of assessing radioactive concentration distribution in soil (ADS). These tests include the techniques of measuring and assessing very low radioactive concentration distribution on the extensive surfaces of buildings and the soil surrounding of a plant with automatic devices. Technical investigation and preliminary study of the verification tests were started in 1990. In the study, preconditions were clarified for each technique and the performance requirements were set up. Moreover, simulation models have been constructed for several feasible measurement method to assess their performance in terms of both measurement test and simulation analysis. Fundamental tests have been under way using small-scale apparatuses since 1994

  12. Cluster Detection Tests in Spatial Epidemiology: A Global Indicator for Performance Assessment.

    Directory of Open Access Journals (Sweden)

    Aline Guttmann

    Full Text Available In cluster detection of disease, the use of local cluster detection tests (CDTs is current. These methods aim both at locating likely clusters and testing for their statistical significance. New or improved CDTs are regularly proposed to epidemiologists and must be subjected to performance assessment. Because location accuracy has to be considered, performance assessment goes beyond the raw estimation of type I or II errors. As no consensus exists for performance evaluations, heterogeneous methods are used, and therefore studies are rarely comparable. A global indicator of performance, which assesses both spatial accuracy and usual power, would facilitate the exploration of CDTs behaviour and help between-studies comparisons. The Tanimoto coefficient (TC is a well-known measure of similarity that can assess location accuracy but only for one detected cluster. In a simulation study, performance is measured for many tests. From the TC, we here propose two statistics, the averaged TC and the cumulated TC, as indicators able to provide a global overview of CDTs performance for both usual power and location accuracy. We evidence the properties of these two indicators and the superiority of the cumulated TC to assess performance. We tested these indicators to conduct a systematic spatial assessment displayed through performance maps.

  13. Cluster Detection Tests in Spatial Epidemiology: A Global Indicator for Performance Assessment

    Science.gov (United States)

    Guttmann, Aline; Li, Xinran; Feschet, Fabien; Gaudart, Jean; Demongeot, Jacques; Boire, Jean-Yves; Ouchchane, Lemlih

    2015-01-01

    In cluster detection of disease, the use of local cluster detection tests (CDTs) is current. These methods aim both at locating likely clusters and testing for their statistical significance. New or improved CDTs are regularly proposed to epidemiologists and must be subjected to performance assessment. Because location accuracy has to be considered, performance assessment goes beyond the raw estimation of type I or II errors. As no consensus exists for performance evaluations, heterogeneous methods are used, and therefore studies are rarely comparable. A global indicator of performance, which assesses both spatial accuracy and usual power, would facilitate the exploration of CDTs behaviour and help between-studies comparisons. The Tanimoto coefficient (TC) is a well-known measure of similarity that can assess location accuracy but only for one detected cluster. In a simulation study, performance is measured for many tests. From the TC, we here propose two statistics, the averaged TC and the cumulated TC, as indicators able to provide a global overview of CDTs performance for both usual power and location accuracy. We evidence the properties of these two indicators and the superiority of the cumulated TC to assess performance. We tested these indicators to conduct a systematic spatial assessment displayed through performance maps. PMID:26086911

  14. Assessment of fitness to drive after acquired brain injury: The role of neuropsychological tests

    DEFF Research Database (Denmark)

    Meng, Annette

    It is a well established fact that Acquired Brain Injury (ABI) can affect fitness to drive. Some cognitive functions have been emphasized as particular important when driving e.g. attention, reaction time, visual perception, and executive functioning. Research attempts have been made in order...... to identify a neuropsychological test battery to predict driving ability. However, there is no consensus as to which test such a test battery should consist of. The aim of this study was to explore the relationship between some neuropsychological test results and the results of an on-road test.......g. WCST will not predict the driving ability of this group. This illustrates that many things can affect the predictive value a neuropsychological test and the belief that neuropsychological testing on its own cannot predict fitness to drive. As findings in the field of driving assessment of older people...

  15. Assessment of implicit personality self-concept using the implicit association test (IAT): concurrent assessment of anxiousness and angriness.

    Science.gov (United States)

    Schnabel, Konrad; Banse, Rainer; Asendorpf, Jens B

    2006-06-01

    This study explored the psychometric properties of the Implicit Association Test (IAT) when it is employed for the assessment of two personality traits within one sample. The sequence of an anxiousness and an angriness IAT was counterbalanced across 100 participants and the IATs' predictive validity for anxious versus angry behaviour after emotion inductions was examined and compared to direct self-report measures. The anxiousness IAT added incremental validity over direct measures for the prediction of anxious behaviour. The angriness IAT was affected by an order effect. When the angriness IAT was completed after the anxiousness IAT both tests correlated with r=.46 whereas they were not significantly correlated when the angriness IAT was completed first. Direct anxiousness and angriness measures were uncorrelated. Implications for the assessment of multiple implicit personality self-concept dimensions are discussed.

  16. Test-retest reliability of Brazilian version of Memorial Symptom Assessment Scale for assessing symptoms in cancer patients.

    Science.gov (United States)

    Menezes, Josiane Roberta de; Luvisaro, Bianca Maria Oliveira; Rodrigues, Claudia Fernandes; Muzi, Camila Drumond; Guimarães, Raphael Mendonça

    2017-01-01

    To assess the test-retest reliability of the Memorial Symptom Assessment Scale translated and culturally adapted into Brazilian Portuguese. The scale was applied in an interview format for 190 patients with various cancers type hospitalized in clinical and surgical sectors of the Instituto Nacional de Câncer José de Alencar Gomes da Silva and reapplied in 58 patients. Data from the test-retest were double typed into a Microsoft Excel spreadsheet and analyzed by the weighted Kappa. The reliability of the scale was satisfactory in test-retest. The weighted Kappa values obtained for each scale item had to be adequate, the largest item was 0.96 and the lowest was 0.69. The Kappa subscale was also evaluated and values were 0.84 for high frequency physic symptoms, 0.81 for low frequency physical symptoms, 0.81 for psychological symptoms, and 0.78 for Global Distress Index. High level of reliability estimated suggests that the process of measurement of Memorial Symptom Assessment Scale aspects was adequate. Avaliar a confiabilidade teste-reteste da versão traduzida e adaptada culturalmente para o português do Brasil do Memorial Symptom Assessment Scale. A escala foi aplicada em forma de entrevista em 190 pacientes com diversos tipos de câncer internados nos setores clínicos e cirúrgicos do Instituto Nacional de Câncer José de Alencar Gomes da Silva e reaplicada em 58 pacientes. Os dados dos testes-retestes foram inseridos num banco de dados por dupla digitação independente em Excel e analisados pelo Kappa ponderado. A confiabilidade da escala mostrou-se satisfatória nos testes-retestes. Os valores do Kappa ponderado obtidos para cada item da escala apresentaram-se adequados, sendo o maior item de 0,96 e o menor de 0,69. Também se avaliou o Kappa das subescalas, sendo de 0,84 para sintomas físicos de alta frequência, de 0,81 para sintomas físicos de baixa frequência, de 0,81 também para sintomas psicológicos, e de 0,78 para Índice Geral de Sofrimento

  17. Developing and pilot testing of a tool for "clinicosocial case study" assessment of community medicine residents.

    Science.gov (United States)

    Gohel, Manisha; Singh, Uday Shankar; Bhanderi, Dinesh; Phatak, Ajay

    2016-01-01

    Practical and clinical skills teaching should constitute a core part of the postgraduate curriculum of Community Medicine. The clinicosocial case study is a method to enhance learners' skills but there is no generally accepted organized system of formative assessment and structured feedback to guide students. A new tool based on the principles of mini-Clinical Evaluation Exercise (mini CEX) was developed and pilot tested as a 'clinicosocial case study' assessment of community medicine residents with feedback as a core component. Ten core domains of clinicosocial skills were identified after reviewing the relevant literature and input from local experts in community medicine and medical education. We pilot tested the tool with eight faculty members to assess five residents during clinicosocial case presentations on a variety of topics. Kappa statistic and Bland Altman plots were used to assess agreement between faculty members' average assessment scores. Cronbach's alpha was used to test the internal consistency with faculty members as domains. All 95% confidence limits using the Bland-Altman method were within the predetermined limit of 2 points. The overall Kappa between two faculty members was fair ranging from 0.2 to 0.3. Qualitative feedback revealed that both faculty and residents were enthusiastic about the process but faculty suggested further standardization, while residents suggested streamlining of the process. This new assessment tool is available for objective and unbiased assessment of residents through 'clinicosocial case study,' which enriches learning through comprehensive feedback. Further validation in different settings is needed.

  18. Joint Ordnance Test Procedure (JOTP)-010 Safety and Suitability for Service Assessment Testing for Shoulder Launched Munitions

    Science.gov (United States)

    2016-05-09

    A. BACKGROUND/RATIONALE. ANNEX 1. ENVIRONMENTAL TESTS. A.1-16 TABLE A-4. HELICOPTER MAIN ROTOR PARAMETERS HELICOPTER MAIN ROTOR ...3.1.2.3.2 A.1-15 C.2-4.1.2 C.2-6 Helicopter Cargo Transportation Vibration A.1-3.1.2.3.3 A.1-15 C.2-4.2 C.2-7 Parachute Delivery A.1-3.1.2.3.4 A.1-16...inspection. This is typified by destructive inspection assessing the chemical ( composition , hazard properties, etc.) and physical (tensile, hardness, etc

  19. Assessment of classroom performance of trainees in nondestructive testing (NDT) training courses

    International Nuclear Information System (INIS)

    Elauria, Erla Rhysa R.; Banaga, Renato T.; Loterina, Roel A.

    2009-01-01

    Criterion-referenced tests in an NDT course for Radiography, Level 2, are constructed and evaluated using item analysis such as item difficulty index and discrimination index. A 10-part test item was given to 37 students in a Radiography course and an item analysis of the test questions was conducted right after.The results showed that the indices of difficulty of the test items were within the desired values. Three of the test items were relatively easy questions (items 2, 3, and 4). Three of the test items were moderately difficult (items 1, 5, and 10). The discriminating indices of the items revealed acceptable values for all but a low value of 0.2 for two test items (item 2 and 10) were measured. These two items should be modified to increase their discriminating ability or eliminated. The study concluded that the said test is a reliable test with adequate discriminatory power in assessing classroom performance of NDT trainees. The study recommended that similar studies be conducted on other NDT methods like Ultrasonic Testing, Eddy Current Testing, and Surface Methods Testing. (author)

  20. Negotiating the use of formative assessment for learning in an era of accountability testing

    Science.gov (United States)

    Yin, Xinying

    The purpose of this collaborative action research was to understand how science educators can negotiate the tension between integrating formative assessment (FA) for students' learning and meeting the need for standardized summative assessment (testing) from a critical perspective. Using formative assessment in the era of accountability testing was a process in which the science educators identified the ways that the standardized testing system constrained the teacher's use of FA to improve students' learning, sought solutions to overcome the obstacles and came to understand how FA can be utilized to neutralize the power relationship between the institutional requirement and classroom teaching and learning. The challenge of doing FA under the pressure of standardized testing mainly lie in two dimensions: one was the demand of teaching all the desired standard-based content to all students in a limited amount of time and the sufficient time and flexibility required by doing FA to improve students' understanding, the other was the different levels of knowledge and forms of knowledge representation on FA and tests. The negotiation of doing FA for teaching standards and preparing students for tests entailed six aspects for the collaborative team, including clarifying teaching objectives, reconstructing instructional activities, negotiating with time constraints, designing effective FA activities, attending to students' needs in doing FA, and modifying end-of-unit tests to better assess the learning goals. As the teacher's instructional goals evolved to be more focused on conceptual understanding of standards and more thorough understanding for less activities, she perceived doing FA for learning and preparing students for standardized tests as more congruent. By integrating both divergent and convergent FA into instruction as well as modifying tests to be more aligned with standards, students' learning were enhanced and they were also being prepared for tests. This

  1. Pulmonary rehabilitation in lung transplant candidates.

    Science.gov (United States)

    Li, Melinda; Mathur, Sunita; Chowdhury, Noori A; Helm, Denise; Singer, Lianne G

    2013-06-01

    While awaiting lung transplantation, candidates may participate in pulmonary rehabilitation to improve their fitness for surgery. However, pulmonary rehabilitation outcomes have not been systematically evaluated in lung transplant candidates. This investigation was a retrospective cohort study of 345 pre-transplant pulmonary rehabilitation participants who received a lung transplant between January 2004 and June 2009 and had available pre-transplant exercise data. Data extracted included: 6-minute walk tests at standard intervals; exercise training details; health-related quality-of-life (HRQL) measures; and early post-transplant outcomes. Paired t-tests were used to examine changes in the 6MW distance (6MWD), exercise training volume and HRQL during the pre-transplant period. We evaluated the association between pre-transplant 6MWD and transplant hospitalization outcomes. The final 6MWD prior to transplantation was only 15 m less than the listing 6MWD (n = 200; p = 0.002). Exercise training volumes increased slightly from the start of the pulmonary rehabilitation program until transplant: treadmill, increase 0.69 ml/kg/min (n = 238; p volumes are well preserved among lung transplant candidates participating in pulmonary rehabilitation, even in the setting of severe, progressive lung disease. Participants with greater exercise capacity prior to transplantation have more favorable early post-transplant outcomes. Copyright © 2013 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

  2. Energy Beverage Consumption Among Naval Aviation Candidates.

    Science.gov (United States)

    Sather, Thomas E; Delorey, Donald R

    2016-06-01

    Since the debut of energy beverages, the consumption of energy beverages has been immensely popular with young adults. Research regarding energy beverage consumption has included college students, European Union residents, and U.S. Army military personnel. However, energy beverage consumption among naval aviation candidates in the United States has yet to be examined. The purpose of this study was to assess energy beverage consumption patterns (frequency and volume) among naval aviation candidates, including attitudes and perceptions regarding the benefits and safety of energy beverage consumption. A 44-item survey was used to assess energy beverage consumption patterns of 302 students enrolled in the Aviation Preflight Indoctrination Course at Naval Air Station Pensacola, FL. Results indicated that 79% of participants (N = 239) reported consuming energy beverages within the last year. However, of those who reported consuming energy beverages within the last year, only 36% (N = 85) reported consuming energy beverages within the last 30 d. Additionally, 51% (N = 153) of participants reported no regular energy beverages consumption. The majority of participants consumed energy beverages for mental alertness (67%), mental endurance (37%), and physical endurance (12%). The most reported side effects among participants included increased mental alertness (67%), increased heart rate (53%), and restlessness (41%). Naval aviation candidates appear to use energy drinks as frequently as a college student population, but less frequently than expected for an active duty military population. The findings of this study indicate that naval aviation candidates rarely use energy beverages (less than once per month), but when consumed, they use it for fatigue management.

  3. Developmental assessment of RELAP5/MOD3 using the semiscale natural circulation tests

    International Nuclear Information System (INIS)

    Carlson, K.E.

    1990-01-01

    A code development effort creating RELAP5/MOD3 from RELAP5/MOD2 has been completed. Upon completion, a developmental assessment task was performed. One of the problems used for the developmental assessment was the Semiscale Natural Circulation Test. Calculated results from RELAP5/MOD3 are compared to measured data and previously calculated results from RELAP5/MOD2. 10 refs., 6 figs., 1 tab

  4. Handbook of safety assessment of nanomaterials from toxicological testing to personalized medicine

    CERN Document Server

    Fadeel, Bengt

    2014-01-01

    "The Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine provides a comprehensive overview of the state of the art of nanotoxicology and is a unique resource that fills up many knowledge gaps in the toxicity issue of nanomaterials in medical applications. The book is distinguished by up-to-date insights into creating a science-based framework for safety assessment of nanomedicines." -Prof. Yuliang Zhao, National Center for Nanosciences and Technology, China.

  5. An Analysis Of Tensile Test Results to Assess the Innovation Risk for an Additive Manufacturing Technology

    Directory of Open Access Journals (Sweden)

    Adamczak Stanisław

    2015-03-01

    Full Text Available The aim of this study was to assess the innovation risk for an additive manufacturing process. The analysis was based on the results of static tensile tests obtained for specimens made of photocured resin. The assessment involved analyzing the measurement uncertainty by applying the FMEA method. The structure of the causes and effects of the discrepancies was illustrated using the Ishikawa diagram. The risk priority numbers were calculated. The uncertainty of the tensile test measurement was determined for three printing orientations. The results suggest that the material used to fabricate the tensile specimens shows clear anisotropy of the properties in relation to the printing direction.

  6. Underground Test Area Subproject Phase I Data Analysis Task. Volume VIII - Risk Assessment Documentation Package

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-12-01

    Volume VIII of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the risk assessment documentation. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

  7. Environmental risk assessment and management of engineered nanomaterials - The role of ecotoxicity testing

    DEFF Research Database (Denmark)

    Hjorth, Rune

    replaced with a focus on in silico and in vitro studies with an even greater need for and reliance on extrapolation. However, in this thesis it is argued that within ecotoxicity, whole organism models remain at the foundation of environmental risk assessment, and as such, they are likely to remain in use...... will be available, it is important that tools encompassing uncertainty are utilized to facilitate decision-support. As the risk constituted by ENMs cannot be quantified, the use, need and ability of risk management options to encompass the potential risk are similarly challenged. This should invoke a precautionary...... to these is the continued examination of the applicability of ecotoxicity testing to encompass the testing of particles, as the tests originally are developed for dissolved chemicals. Furthermore, the ability of such testing to inform environmental risk assessment and environmental risk management, including...

  8. Environmental assessment of SP-100 ground engineering system test site: Hanford Site, Richland, Washington

    Energy Technology Data Exchange (ETDEWEB)

    1988-12-01

    The US Department of Energy (DOE) proposes to modify an existing reactor containment building (decommissioned Plutonium Recycle Test Reactor (PRTR) 309 Building) to provide ground test capability for the prototype SP-100 reactor. The 309 Building (Figure 1.1) is located in the 300 Area on the Hanford Site in Washington State. The National Environmental Policy Act (NEPA) requires that Federal agencies assess the potential impacts that their actions may have on the environment. This Environmental Assessment describes the consideration given to environmental impacts during reactor concept and test site selection, examines the environmental effects of the DOE proposal to ground test the nuclear subsystem, describes alternatives to the proposed action, and examines radiological risks of potential SP-100 use in space. 73 refs., 19 figs., 7 tabs.

  9. EOS suspension test for the assessment of spinal flexibility in adolescent idiopathic scoliosis.

    Science.gov (United States)

    Hirsch, Caroline; Ilharreborde, Brice; Mazda, Keyvan

    2015-07-01

    The assessment of spinal flexibility is essential for the planning of adolescent idiopathic scoliosis (AIS) surgery. Various radiographic methods have been used but none of them has shown any superiority. The new low-dose stereography system EOS (EOS imaging, Paris, France) captures whole body images in a single scan without vertical distortion. EOS is now used in routine clinical use for AIS follow-up. The aim of this study was to prospectively evaluate the feasibility and the reproducibility of a new suspension test during the EOS imaging for the assessment of spinal flexibility in AIS. Fifty AIS patients scheduled for surgery were prospectively included. For each patient, a standard EOS radiograph was obtained, then a suspension test in the EOS and a classic traction test on the cotrel frame were performed. The examinations were compared in terms of radiation exposure, tolerance, mean traction force, and Cobb angle reduction for each curve. Axial and sagittal reductions during suspension were analyzed on three-dimensional EOS reconstructions. The tolerance of the suspension test was lower than the traction test but it was less operator dependent. Radiation exposure was 7 times lower during the suspension test. Cobb angle reductions achieved in the proximal and main curves by the two tests were similar. The traction test achieved greater reduction of the distal curve. Flexibility in the axial plane and in the sagittal plane was analyzed with the suspension test. The reduction in apical rotation was not correlated with the reduction in Cobb angle. The EOS suspension test can be used for the assessment of spinal flexibility in AIS. It gives a global vision of the deformity with new flexibility indices in the axial and sagittal planes.

  10. Biaxial testing for nuclear grade graphite by ball on three balls assessment

    International Nuclear Information System (INIS)

    Mohd Reusmaazran Yusof; Yusof Abdullah

    2012-01-01

    Nuclear grade (high-purity) graphite for fuel element and moderator material in Advanced Gas Cooling Reactors (AGR) displays large scatter in strength and a non-linear stress-strain response from the damage accumulation. These responses can be characterized as quasi-brittle behaviour. Current assessments of fracture in core graphite components are based on the linear elastic approximation and thus represent a major assumption. The quasi-brittle behaviour gives challenge to assess the real nuclear graphite component. The selected test method would help to bridge the gap between microscale to macro-scale in real reactor component. The small scale tests presented here can contribute some statistical data to manifests the failure in real component. The evaluation and choice of different solution design of biaxial test will be discussed in this paper. The ball on-three ball test method was used for assessment test follows by numerous of analytical method. The results shown that biaxial strength of the EY9 grade graphite depends on the method used for evaluation. Some of the analytical methods use to calculate biaxial strength were found not to be valid and therefore should not be used to assess the mechanical properties of nuclear graphite. (author)

  11. SELF-ASSESSMENT, QUESTIONNAIRES AND MEMORY TESTS IN A SIMULATED DRIVING TASK

    OpenAIRE

    Combe-Pangaud , Chantal; Jacquet-Andrieu , Armelle

    2009-01-01

    disponible sur : http://www.chalmers.se/safer/driverdistraction-en; International audience; This paper concerns the results of a memorizing test (visual recognition and hearing recall) during an experiment of simulated driving in a magneto-encephalographic environment. The memory tests (questionnaires) are adapted to the measurement of subjective self-assessment: "tiredness" and "facility" perceptions, corralled to simple (ST) and double task (ST/DT: hearing a radio broadcast). Each subject h...

  12. Strength assessment of a cryostat used by the hollow electron test station.

    CERN Document Server

    Efremov, Filip

    2015-01-01

    The following report explains the work I have done on my summer student work project and the experience I have gained during the process. The work consisted of a strength assessment of a cryogenic vacuum insulated vessel according to European regulations. The cryogenic vacuum insulated vessel is used for the cooling of the solenoids. The solenoids are used in the hollow electron test station and create the magnetic fields used for testing electron guns and validating the concept of a hollow electron lens.

  13. Reliability of core test – Critical assessment and proposed new approach

    OpenAIRE

    Shafik Khoury; Ali Abdel-Hakam Aliabdo; Ahmed Ghazy

    2014-01-01

    Core test is commonly required in the area of concrete industry to evaluate the concrete strength and sometimes it becomes the unique tool for safety assessment of existing concrete structures. Core test is therefore introduced in most codes. An extensive literature survey on different international codes’ provisions; including the Egyptian, British, European and ACI Codes, for core analysis is presented. All studied codes’ provisions seem to be unreliable for predicting the in-situ concrete ...

  14. Emergency department assessment of abdominal pain: clinical indicator tests for detecting peritonism.

    Science.gov (United States)

    Taylor, Scott; Watt, Martin

    2005-12-01

    Peritonism is a finding that leads to a more cautious approach in the emergency department management of abdominal pain. This study examined whether peritonism assessment using inspiration, expiration and cough tests was associated with the patient's clinical management. This prospective observational study evaluated consecutive patients presenting directly to the emergency department for 3 months from June 2000 with abdominal pain. Triage initial observations of blood pressure, pulse, respiratory rate, oxygen saturation and temperature were recorded. The examining emergency physician recorded each patient's response and pain score to the individual peritonism tests and scored it as positive if there was an indication of it being a painful manoeuvre. The results were blinded from the receiving specialty if subsequent referral was required. Sixty-seven patients had peritonism tests performed. No individual test was more painful than the others with similar values in pain scores. In all, 70% (7/10) were admitted when all three tests were positive, compared with 21% (12/57) when two or less of the tests scored positive (P=0.004, Fisher's exact test). Admission was not associated with any individual test or combination of tests, or any other variable. The peritonism tests were not associated with any other physiological observation or measurement. These peritonism tests represent a simple investigation, and are significantly associated with admission when all three tests are positive. They seem to be a clinical predictor of cases in which continuing assessment was required, and may be useful as a departmental 'safety net' in the management of abdominal pain.

  15. Should we assess climate model predictions in light of severe tests?

    Science.gov (United States)

    Katzav, Joel

    2011-06-01

    According to Austro-British philosopher Karl Popper, a system of theoretical claims is scientific only if it is methodologically falsifiable, i.e., only if systematic attempts to falsify or severely test the system are being carried out [Popper, 2005, pp. 20, 62]. He holds that a test of a theoretical system is severe if and only if it is a test of the applicability of the system to a case in which the system's failure is likely in light of background knowledge, i.e., in light of scientific assumptions other than those of the system being tested [Popper, 2002, p. 150]. Popper counts the 1919 tests of general relativity's then unlikely predictions of the deflection of light in the Sun's gravitational field as severe. An implication of Popper's above condition for being a scientific theoretical system is the injunction to assess theoretical systems in light of how well they have withstood severe testing. Applying this injunction to assessing the quality of climate model predictions (CMPs), including climate model projections, would involve assigning a quality to each CMP as a function of how well it has withstood severe tests allowed by its implications for past, present, and nearfuture climate or, alternatively, as a function of how well the models that generated the CMP have withstood severe tests of their suitability for generating the CMP.

  16. Systematic evaluation of non-animal test methods for skin sensitisation safety assessment.

    Science.gov (United States)

    Reisinger, Kerstin; Hoffmann, Sebastian; Alépée, Nathalie; Ashikaga, Takao; Barroso, Joao; Elcombe, Cliff; Gellatly, Nicola; Galbiati, Valentina; Gibbs, Susan; Groux, Hervé; Hibatallah, Jalila; Keller, Donald; Kern, Petra; Klaric, Martina; Kolle, Susanne; Kuehnl, Jochen; Lambrechts, Nathalie; Lindstedt, Malin; Millet, Marion; Martinozzi-Teissier, Silvia; Natsch, Andreas; Petersohn, Dirk; Pike, Ian; Sakaguchi, Hitoshi; Schepky, Andreas; Tailhardat, Magalie; Templier, Marie; van Vliet, Erwin; Maxwell, Gavin

    2015-02-01

    The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitization potency prediction. The results of the first phase – systematic evaluation of 16 test methods – are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data,potential for throughput, transferability and accessibility in cooperation with the test method developers.A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy – combined with bioavailability and skin metabolism data and exposure consideration – is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients.

  17. CLINICAL TESTS FOR THE ASSESSMENT OF THE PELVIC GIRDLE PAIN IN PREGNANCY AND POSTPARTUM

    Directory of Open Access Journals (Sweden)

    Darija Šćepanović

    2018-02-01

    Full Text Available Background: Pregnancy-related pelvic girdle pain (PGP refers to the pain in the lumbosacral region, the sacroiliac joints and the symphysis pubis joint. The results of the high methodological quality studies indicate that the point prevalence of pregnant women suffering from PGP is about 20 %. Pregnancy-related PGP requires a comprehensive physiotherapy assessment in order to make or confirm a diagnosis, plan the treatment and evaluate the patient’s condi- tion. Physiotherapy assessment includes clinical diagnostic tests which should satisfy the criteria of safety, feasibility, reliability, sensitivity, specificity and validity. The aim of the present paper was to systematically review the literature on clinical diagnostic tests of PGP in order to determine which clinical tests meet the necessary criteria and are appropriate for clinical examination of PGP in pregnancy and postpartum. Methods: PubMed, Cinahl, Embase, Index Medicus databases and the Cochrane controlled trials reg- ister from 1980 to 2008 were searched using the key words, pregnancy/pelvic girdle pain, pregnancy/clinical tests/sacroiliac joint/symphysis pubis. Only the articles/texts in English and Slovene were reviewed unless translated abstract was available. Additional manual searches of the reference lists in books and review articles were undertaken. Along with the randomized clinical studies the literature search encompassed also the basic studies. Results: Nine studies evaluating the tests for clinical examination of the pregnancy-related PGP met the criteria for inclusion in this review. The studies evaluated and analysed six provocation tests for the sacroiliac joint, namely, the Posterior pelvic pain provocation test (P4, Patrick’s Faber test, palpation of the long dorsal ligament, compression test, separation test, Menell’s test as well as two provocation tests for the symphysis pubis joint (pain palpation and a modified Trendelenburg test and one functional

  18. A virtual reality test battery for assessment and screening of spatial neglect.

    Science.gov (United States)

    Fordell, H; Bodin, K; Bucht, G; Malm, J

    2011-03-01

    There is a need for improved screening methods for spatial neglect. To construct a VR-test battery and evaluate its accuracy and usability in patients with acute stroke. VR-DiSTRO consists of a standard desktop computer, a CRT monitor and eye shutter stereoscopic glasses, a force feedback interface, and software, developed to create an interactive and immersive 3D experience. VR-tests were developed and validated to the conventional Star Cancellation test, Line bisection, Baking Tray Task (BTT), and Visual Extinction test. A construct validation to The Rivermead Behavioral Inattention Test, used as criterion of visuospatial neglect, was made. Usability was assessed according to ISO 9241-11. Thirty-one patients with stroke were included, 9/31 patients had neglect. The sensitivity was 100% and the specificity 82% for the VR-DiSTRO to correctly identify neglect. VR-BTT and VR-Extinction had the highest correlation (r² = 0.64 and 0.78), as well as high sensitivity and specificity. The kappa values describing the agreement between traditional neglect tests and the corresponding virtual reality test were between 0.47-0.85. Usability was assessed by a questionnaire; 77% reported that the VR-DiSTRO was 'easy' to use. Eighty-eight percent reported that they felt 'focused', 'pleased' or 'alert'. No patient had adverse symptoms. The test session took 15 min. The VR-DiSTRO quickly and with a high accuracy identified visuospatial neglect in patients with stroke in this construct validation. The usability among elderly patients with stroke was high. This VR-test battery has the potential to become an important screening instrument for neglect and a valuable adjunct to the neuropsychological assessment. © 2010 John Wiley & Sons A/S.

  19. Model testing for the remediation assessment of a radium contaminated site in Olen, Belgium

    International Nuclear Information System (INIS)

    Sweeck, Lieve; Kanyar, Bela; Krajewski, Pawel; Kryshev, Alexander; Lietava, Peter; Nenyei, Arpad; Sazykina, Tatiana; Yu, Charley; Zeevaert, Theo

    2005-01-01

    Environmental assessment models are used as decision-aiding tools in the selection of remediation options for radioactively contaminated sites. In most cases, the effectiveness of the remedial actions in terms of dose savings cannot be demonstrated directly, but can be established with the help of environmental assessment models, through the assessment of future radiological impacts. It should be emphasized that, given the complexity of the processes involved and our current understanding of how they operate, these models are simplified descriptions of the behaviour of radionuclides in the environment and therefore imperfect. One way of testing and improving the reliability of the models is to compare their predictions with real data and/or the predictions of other models. Within the framework of the Remediation Assessment Working Group (RAWG) of the BIOMASS (BIOsphere Modelling and ASSessment) programme coordinated by IAEA, two scenarios were constructed and applied to test the reliability of environmental assessment models when remedial actions are involved. As a test site, an area of approximately 100 ha contaminated by the discharges of an old radium extraction plant in Olen (Belgium) has been considered. In the first scenario, a real situation was evaluated and model predictions were compared with measured data. In the second scenario the model predictions for specific hypothetical but realistic situations were compared. Most of the biosphere models were not developed to assess the performance of remedial actions and had to be modified for this purpose. It was demonstrated clearly that the modeller's experience and familiarity with the mathematical model, the site and with the scenario play a very important role in the outcome of the model calculations. More model testing studies, preferably for real situations, are needed in order to improve the models and modelling methods and to expand the areas in which the models are applicable

  20. Balancing technical and regulatory concerns related to testing and control of performance assessment software

    International Nuclear Information System (INIS)

    Seitz, R.R.; Matthews, S.D.; Kostelnik, K.M.

    1990-01-01

    What activities are required to assure that a performance assessment (PA) computer code operates as it is intended? Answers to this question will vary depending on the individual's area of expertise. Different perspectives on testing and control of PA software are discussed based on interpretations of the testing and control process associated with the different involved parties. This discussion leads into the presentation of a general approach to software testing and control that address regulatory requirements. Finally, the need for balance between regulatory and scientific concerns is illustrated through lessons learned in previous implementations of software testing and control programs. Configuration control and software testing are required to provide assurance that a computer code performs as intended. Configuration control provides traceability and reproducibility of results produced with PA software and provides a system to assure that users have access to the current version of the software. Software testing is conducted to assure that the computer code has been written properly, solution techniques have been properly implemented, and the software is capable of representing the behavior of the specific system to be modeled. Comprehensive software testing includes: software analysis, verification testing, benchmark testing, and site-specific calibration/validation testing