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Sample records for terris phd associate

  1. Use of the Brandley-Terry Model to Quantify Association in Remotely Sensed Images

    NARCIS (Netherlands)

    Stein, A.; Aryal, J.; Gort, G.

    2005-01-01

    Thematic maps prepared from remotely sensed images require a statistical accuracy assessment. For this purpose, the$kappa$-statistic is often used. This statistic does not distinguish between whether one unit is classified as another, or vice versa. In this paper, the Bradley-Terry (BT) model is

  2. Craig Reynolds, Ph.D., to Retire as NCI Associate Director for Frederick | Poster

    Science.gov (United States)

    On December 2, Craig Reynolds, Ph.D., director, Office of Scientific Operations, and NCI associate director for Frederick, will put the finishing touches on a 37-year career with the National Cancer Institute.

  3. Terri Schiavo: een ethische analyse

    NARCIS (Netherlands)

    Boer, Th.A.

    2005-01-01

    Terri Schiavo verkeerde na een ongeval vele jaren in een persistente vegatatieve toestand. Haar man vond, dat de kunstmatige voeding die ze kreeg na verloop van tijd moest worden gestaakt. Schiavo's ouders vochten die visie aan. De rechtszaak kwam tot in het Amerikaanse hooggerechtshof. Uiteindelijk

  4. GM-PHD Filter Combined with Track-Estimate Association and Numerical Interpolation

    Directory of Open Access Journals (Sweden)

    Jinguang Chen

    2015-01-01

    Full Text Available For the standard Gaussian mixture probability hypothesis density (GM-PHD filter, the number of targets can be overestimated if the clutter rate is too high or underestimated if the detection rate is too low. These problems seriously affect the accuracy of multitarget tracking for the number and the value of measurements and clutters cannot be distinguished and recognized. Therefore, we proposed an improved GM-PHD filter to tackle these problems. Firstly, a track-estimate association was implemented in the filtering process to detect and remove false-alarm targets. Secondly, a numerical interpolation technique was used to compensate the missing targets caused by low detection rate. At the end of this paper, simulation results were presented to demonstrate the proposed GM-PHD algorithm is more effective in estimating the number and state of targets than the previous ones.

  5. Terry Miller : Eesti on majandusvabaduse maailmas kangelane

    Index Scriptorium Estoniae

    2008-01-01

    Majanduskonverentsil Restart esinenud pikaajalise kogemusega karjääridiplomaadi Terry Milleri hinnang Eesti majandusvabadusele. Eesti on maailma majandusvabaduse indeksi 12. kohal, kuid tööturu vabaduse osas on Eesti viimaste hulgas. Lisa: Majandusvabadus suurendab rahvuslikku rikkust

  6. Profile Terry Young: man of the match

    CERN Multimedia

    2003-01-01

    Terry Young, chair of health systems at Brunel University, has received a grant of 3.3 million pounds from EPSRC. The money will create the Multidisciplinary Assessment of Technology Centre for Health (MATCH). The aim of the centre is to aid the progress of medical devices from concept to patient care by developing criteria to single out promising technologies and helping them to market (1 page).

  7. Geophysical monitoring of the EDZ during a gallery excavation in the Opalinus clay of the Mont Terri URL: anomalies of noble gases and self-potential associated with fractures and fluid dynamics in a horizontal borehole

    International Nuclear Information System (INIS)

    Maineult, A.; Mahiouz, K.; Lesparre, N.; Thomas, B.; Lavielle, B.; Nussbaum, C.; Wieczorek, K.; Gibert, D.; Kergosien, B.; Nicollin, F.

    2012-01-01

    Document available in extended abstract form only. The research underground rock laboratory (URL) of Mont Terri (Switzerland) was established in 1996 in a Mesozoic clay-stone formation (Opalinus Clay). It is aimed at studying the hydro-mechanical, thermal, geochemical and geophysical behaviour of argillaceous formations in the context of radioactive waste disposal. The EZ-G experiments were designed to monitor the EDZ evolution. The EZ-G08 experiment started in September 2007 to study the EDZ changes at different time scales during the tunnelling of gallery Ga08 starting from the northern part of the URL toward the end-face of the gallery Ga04. Before the excavation process started, we characterized the petrology and the structural properties of the core of the horizontal, 12-m long borehole BEZ-G5 drilled in the end-face of gallery Ga04 (first 2 meters in the shaly facies, the rest in the sandy facies). We quantified its noble gas content for studying gas transport processes in rocks and connected fracture networks. Depletion in He can be observed in the EDZ and other noble gases can also increase as desaturation processes occur. Inflows of water occurred in the borehole few weeks after its drilling until the junction of galleries Ga08 and Ga04. Water amounts of few litres were commonly released in other boreholes in the URL. We recorded the natural electrical potentials (self-potentials - SP), in BEZ-G5. SP originate from the movement of fluid, the diffusion of concentration or temperature gradients, and are sensitive to any change occurring in them. Borehole BEZ-G5 was equipped with a specific device, on which custom-made electrodes were fixed every 15 cm. The signals showed coherent perturbations during the drilling operations in the boreholes BEZ-G12 and in the end-face of the gallery Ga04. Afterwards, an early, strong but rather smooth increase of a few tens of mV, followed by a very slow decrease of much smallest amplitude, can be observed in some signals

  8. The Terri Schiavo case: legal, ethical, and medical perspectives.

    Science.gov (United States)

    Perry, Joshua E; Churchill, Larry R; Kirshner, Howard S

    2005-11-15

    Although tragic, the plight of Terri Schiavo provides a valuable case study. The conflicts and misunderstandings surrounding her situation offer important lessons in medicine, law, and ethics. Despite media saturation and intense public interest, widespread confusion lingers regarding the diagnosis of persistent vegetative state, the judicial processes involved, and the appropriateness of the ethical framework used by those entrusted with Terri Schiavo's care. First, the authors review the current medical understanding of persistent vegetative state, including the requirements for patient examination, the differential diagnosis, and the practice guidelines of the American Academy of Neurology regarding artificial nutrition and hydration for patients with this diagnosis. Second, they examine the legal history, including the 2000 trial, the 2002 evidentiary hearing, and the subsequent appeals. The authors argue that the law did not fail Terri Schiavo, but produced the highest-quality evidence and provided the most judicial review of any end-of-life guardianship case in U.S. history. Third, they review alternative ethical frameworks for understanding the Terri Schiavo case and contend that the principle of respect for autonomy is paramount in this case and in similar cases. Far from being unusual, the manner in which Terri Schiavo's case was reviewed and the basis for the decision reflect a broad medical, legal, and ethical consensus. Greater clarity regarding the persistent vegetative state, less apprehension of the presumed mysteries of legal proceedings, and greater appreciation of the ethical principles at work are the chief benefits obtained from studying this provocative case.

  9. Mont Terri project, cyclic deformations in the Opalinus Clay

    International Nuclear Information System (INIS)

    Moeri, A.; Bossart, P.; Matray, J.M.; Mueller, H.; Frank, E.

    2010-01-01

    Document available in extended abstract form only. Shrinkage structures in the Opalinus Clay, related to seasonal changes in temperature and humidity, are observed on the tunnel walls of the Mont Terri Rock Laboratory. The structures open in winter, when relative humidity in the tunnel decreases to 65%. In summer the cracks close again because of the increase in the clay volume when higher humidity causes rock swelling. Shrinkage structures are monitored in the Mont Terri Rock Laboratory at two different sites within the undisturbed rock matrix and a major fault zone. The relative movements of the rock on both sides of the cracks are monitored in three directions and compared to the fluctuations in ambient relative humidity and temperature. The cyclic deformations (CD) experiment aims to quantify the variations in crack opening in relation to the evolution of climatic conditions and to identify the processes underlying these swell and shrinkage cycles. It consists of the following tasks: - Measuring and quantifying the long-term (now up to three yearly cycles) opening and closing and, if present, the associated shear displacements of selected shrinkage cracks along an undisturbed bedding plane as well as within a major fault zone ('Main Fault'). The measurements are accompanied by temperature and humidity records as well as by a long-term monitoring of tunnel convergence. - Analysing at the micro-scale the surfaces of the crack planes to identify potential relative movements, changes in the rock fabric on the crack surfaces and the formation of fault gouge material as observed in closed cracks. - Processing and analysing measured fluctuations of crack apertures and rock deformation in the time series as well as in the hydro-meteorological variables, in particular relative humidity Hr(t) and air temperature. - Studying and reconstructing the opening cycles on a drill-core sample under well-known laboratory conditions and observing potential propagation of

  10. First Ph.D. Student Workshop of the Hermann von Helmholtz Association of National Research Centers (HGF) on ''Nuclear Safety Research''

    International Nuclear Information System (INIS)

    Knebel, J.U.; Sanchez Espinoza, V.H.

    2006-03-01

    The First Ph.D. Student Workshop ''Nuclear Safety Research'' of the Helmholtz Association of National Research Centers (HGF)'' was jointly organized by the Research Center Karlsruhe GmbH and the Energie Baden-Wuerttemberg AG (EnBW) from Wednesday 9th to Friday 11th March 2005. The workshop was opened with welcome greetings by Dr. Peter Fritz, Forschungszentrum Karlsruhe. Subsequently Dr. Joachim U. Knebel explained the main goals and the content of the workshop. The young scientists reported in 28 high-level presentations about their research work which covered a wide spectrum from reactor safety, partitions and transmutation, and innovative reactor systems, to safety research for nuclear waste disposal. The junior researchs showed excellent professional competence and demonstrated presentation qualities at the highest level. The successful funding of two Virtual Institutes, namely: the ''Competence in Nuclear Technologies'' and ''Functional Characteristics of Aquatic Interfaces both co-ordinated by Forschungszentrum Karlsruhe'', by the President of the Helmholtz Association Prof. Walter Kroell was the motivation for the organization of this first Ph.D. Student Workshop. Thanks to these two Virtual Institutes, the Reseach Center Karlsruhe and Juelich together with several univer-sities i.e. RWTH Aachen, Heidelberg, Karlsruhe, Muenster, and Stuttgart, have successfully financed eight Ph.D. and two post-doctoral students. Moreover, young scientists of the European Institute for Transuranium Elements (ITU) and additional seven Ph.D. Students, who are sponsored by the German nuclear industry (Framatome ANP, RWE Power, EnBW) in the frame of the Alliance Competence in on Nuclear Technology, and who are trained at Forschungszentrum Karlsruhe, actively contributed to this workshop. The EnBW-Award was handed over by Dr. Hans-Josef Zimmer, member of the board of directors of the EnBW-Kraftwerksgesellschaft, to Mrs. Ayelet Walter from the University of Stuttgart for the best

  11. Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer

    International Nuclear Information System (INIS)

    Rawluszko, Agnieszka A; Bujnicka, Katarzyna E; Horbacka, Karolina; Krokowicz, Piotr; Jagodziński, Paweł P

    2013-01-01

    demonstrated that reduced PHD3 expression in cancerous tissue was accompanied by methylation of the CpG rich region located within the first exon and intron of the PHD3 gene. The diminished expression of PHD1 and PHD2 and elevated level of FIH protein in cancerous tissue compared to histopathologically unchanged colonic mucosa was not associated with DNA methylation within the CpG islands of the PHD1, PHD2 and FIH genes

  12. ARM-based control system for terry rapier loom

    Science.gov (United States)

    Shi, Weimin; Gu, Yeqing; Wu, Zhenyu; Wang, Fan

    2007-12-01

    In this paper, a novel ARM-based mechatronics control technique applied in terry rapier loom was presented. Electronic weft selection, electronic fluff, electronic let-off and take-up motions system, which consists of position and speedcontrolled servomechanisms, were studied. The control system configuration, operation principle, and mathematical models of electronic drives system were analyzed. The synchronism among all mechanical motions and an improved intelligent control algorithm for the warp let-off tension control was discussed. The result indict that, by applying electronic and embedded control techniques and the individual servomechanisms, the electronic weft selection, electronic let-off device and electronic take-up device in HGA732T terry rapier loom have greatly simplified the initial complicated mechanism, kept the warp tension constant from full to empty beam, set the variable weft density, eliminated the start mark effectively, promoted its flexibility, reliability and properties, and improved the fabric quality.

  13. Microbial investigations in Opalinus clay from Mont Terri and in Callovo-Oxfordian argillite from Meuse/Haute-Marne

    International Nuclear Information System (INIS)

    Poulain, S.

    2006-12-01

    The subject of this Ph.D. thesis deals with research achieved in the context of the Axis 2 of the law Bataille voted on December 30, 1991 about the possibility of building a deep geological repository for medium or high activity and long living nuclear waste. Nearby such a site, some microorganisms may influence the mobility of radionuclides coming from the waste canisters. This work consisted in looking for autochthonous microorganisms in the Opalinus clay formation from Mont Terri (Switzerland) and in the Callovo-Oxfordian argillite from Meuse/Haute-Marne (France). Microbial Investigations in these unknown unperturbed environments suggested very low microbial densities in the clayey sediments. However, new bacterial species could be isolated from those samples. In addition, a part of the allochthonous population, which has been introduced by air and human activity, could be identified in the Meuse/Haute-Marne underground research laboratory. (author)

  14. Mont Terri Project - Proceedings of the 10 Year Anniversary Workshop

    International Nuclear Information System (INIS)

    Hugi, M.; Bossart, P.; Hayoz, P.

    2007-01-01

    This book is a compilation of 12 reports presented at the St-Ursanne workshop. The workshop was dedicated to the scientific community of the Mont Terri partner organisations, their management and scientific/technical staff, involved research organisations and key contractors. The purpose of the event was to acknowledge the excellent research work that has been performed over the last decade, to evaluate and discuss the present state of knowledge in selected research areas and to explore the potential for future research activities. The topical areas addressed in the workshop are of particular importance with regard to deep geological disposal of radioactive waste and focused on the issues of coupled phenomena and transport processes in argillaceous rock and the demonstration (in underground rock laboratories) of disposal feasibility. After showing the history of the Mont Terri project and the general geology of Northwestern Switzerland, the different presentations are distributed into 3 topics: (a) Coupled phenomena in argillaceous rock, (b) Transport processes in argillaceous rock, and (c) Demonstration of disposal feasibility in underground rock laboratories. The last chapter describes the research still needed and the Mont Terri rock laboratory

  15. SINGLE PHASE ANALYTICAL MODELS FOR TERRY TURBINE NOZZLE

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Haihua; Zhang, Hongbin; Zou, Ling; O' Brien, James

    2016-11-01

    All BWR RCIC (Reactor Core Isolation Cooling) systems and PWR AFW (Auxiliary Feed Water) systems use Terry turbine, which is composed of the wheel with turbine buckets and several groups of fixed nozzles and reversing chambers inside the turbine casing. The inlet steam is accelerated through the turbine nozzle and impacts on the wheel buckets, generating work to drive the RCIC pump. As part of the efforts to understand the unexpected “self-regulating” mode of the RCIC systems in Fukushima accidents and extend BWR RCIC and PWR AFW operational range and flexibility, mechanistic models for the Terry turbine, based on Sandia National Laboratories’ original work, has been developed and implemented in the RELAP-7 code to simulate the RCIC system. RELAP-7 is a new reactor system code currently under development with the funding support from U.S. Department of Energy. The RELAP-7 code is a fully implicit code and the preconditioned Jacobian-free Newton-Krylov (JFNK) method is used to solve the discretized nonlinear system. This paper presents a set of analytical models for simulating the flow through the Terry turbine nozzles when inlet fluid is pure steam. The implementation of the models into RELAP-7 will be briefly discussed. In the Sandia model, the turbine bucket inlet velocity is provided according to a reduced-order model, which was obtained from a large number of CFD simulations. In this work, we propose an alternative method, using an under-expanded jet model to obtain the velocity and thermodynamic conditions for the turbine bucket inlet. The models include both adiabatic expansion process inside the nozzle and free expansion process out of the nozzle to reach the ambient pressure. The combined models are able to predict the steam mass flow rate and supersonic velocity to the Terry turbine bucket entrance, which are the necessary input conditions for the Terry Turbine rotor model. The nozzle analytical models were validated with experimental data and

  16. Report on International Collaboration Involving the FE Heater and HG-A Tests at Mont Terri

    Energy Technology Data Exchange (ETDEWEB)

    Houseworth, Jim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rutqvist, Jonny [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Asahina, Daisuke [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Chen, Fei [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Vilarrasa, Victor [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Liu, Hui-Hai [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Birkholzer, Jens [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2013-11-01

    Nuclear waste programs outside of the US have focused on different host rock types for geological disposal of high-level radioactive waste. Several countries, including France, Switzerland, Belgium, and Japan are exploring the possibility of waste disposal in shale and other clay-rich rock that fall within the general classification of argillaceous rock. This rock type is also of interest for the US program because the US has extensive sedimentary basins containing large deposits of argillaceous rock. LBNL, as part of the DOE-NE Used Fuel Disposition Campaign, is collaborating on some of the underground research laboratory (URL) activities at the Mont Terri URL near Saint-Ursanne, Switzerland. The Mont Terri project, which began in 1995, has developed a URL at a depth of about 300 m in a stiff clay formation called the Opalinus Clay. Our current collaboration efforts include two test modeling activities for the FE heater test and the HG-A leak-off test. This report documents results concerning our current modeling of these field tests. The overall objectives of these activities include an improved understanding of and advanced relevant modeling capabilities for EDZ evolution in clay repositories and the associated coupled processes, and to develop a technical basis for the maximum allowable temperature for a clay repository.

  17. Inclusive Discourse? Local Media Coverage of the Terri Schiavo Case.

    Science.gov (United States)

    Rohlinger, Deana A; Pederson, JoEllen; Valle, Giuseppina

    2015-01-01

    This article contributes to a more systematic understanding of the role of mainstream media in deliberative processes by analyzing how inclusive local newspapers are of diverse perspectives on the Terri Schiavo case. Using both Pearson's chi-square test and multinomial logistic regression, we assess how ownership, state political ideology, geographic location, and news format affect what ideas are included in the debate over whether Terri Schiavo's hydration and nutrition tubes should be removed as well as the tone with which these ideas are discussed. We find that mainstream newspapers are relatively inclusive of diverse ideas and perspectives-regardless of whether the newspaper is independently or corporately owned, the political leanings of the target audience, and the geographic location of the outlet. However, we also find that local newspapers do significantly differ from one another in terms of the frequency and tone with which they include diverse viewpoints. Our research suggests that local outlets downplay ideas that are likely to be regarded as controversial by their target audiences. We conclude with a discussion of the implications of this research for understanding the role of media in deliberative democratic processes in the United States.

  18. John Terry and the Predicament of Englishness: Ambivalence and Nostalgia in the Premier League Era.

    OpenAIRE

    Ewen, Neil

    2013-01-01

    This article examines media discourse surrounding the Chelsea and England footballer John Terry and argues that his iconicity embodies multiple anxieties about Englishness and English football in the era of neoliberalism. In a nostalgic culture in search of ‘traditional’ English heroes, Terry is celebrated for his physicality and traditionally ‘English’ style of play; yet, his off-field behaviour is seen to be both emblematic and symptomatic of a celebrity culture considered to betray the val...

  19. Terry Turbopump Expanded Operating Band Full-Scale Component and Basic Science Detailed Test Plan - Final.

    Energy Technology Data Exchange (ETDEWEB)

    Osborn, Douglas [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Solom, Matthew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-02-01

    This document details the milestone approach to define the true operating limitations (margins) of the Terry turbopump systems used in the nuclear industry for Milestone 3 (full-scale component experiments) and Milestone 4 (Terry turbopump basic science experiments) efforts. The overall multinational-sponsored program creates the technical basis to: (1) reduce and defer additional utility costs, (2) simplify plant operations, and (3) provide a better understanding of the true margin which could reduce overall risk of operations.

  20. Terry Turbopump Analytical Modeling Efforts in Fiscal Year 2016 ? Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Osborn, Douglas; Ross, Kyle; Cardoni, Jeffrey N

    2018-04-01

    This document details the Fiscal Year 2016 modeling efforts to define the true operating limitations (margins) of the Terry turbopump systems used in the nuclear industry for Milestone 3 (full-scale component experiments) and Milestone 4 (Terry turbopump basic science experiments) experiments. The overall multinational-sponsored program creates the technical basis to: (1) reduce and defer additional utility costs, (2) simplify plant operations, and (3) provide a better understanding of the true margin which could reduce overall risk of operations.

  1. Biopolitics, Terri Schiavo, and the sovereign subject of death.

    Science.gov (United States)

    Bishop, Jeffrey P

    2008-12-01

    Humanity does not gradually progress from combat to combat until it arrives at universal reciprocity, where the rule of law finally replaces warfare; humanity installs each of its violences in a system of rules and thus proceeds from domination to domination. (Foucault, 1984, 85) In this essay, I take a note from Michel Foucault regarding the notion of biopolitics. For Foucault, biopolitics has both repressive and constitutive properties. Foucault's claim is that with the rise of modern government, the state became exceedingly concerned about the body politic, the bodies that make up the polis, including the health of those bodies. However, Giorgio Agamben claims that Foucault and all western political philosophy misses the relationship between power and Sovereignty, with disastrous results and totalizing tendencies. I explore the case of Terri Schiavo claiming that the social conservatives have attempted to politicize bare life in its legal maneuverings, but I also show how the social liberals open an uncontrollable space between life and death. Both the left and the right miss the aporia at the heart of western political philosophy, and bioethics is complicit in the totalizing effects of contemporary medicine.

  2. PhD Dissertations

    OpenAIRE

    Redazione Reti Medievali (a cura di)

    2010-01-01

    Report of PhD Dissertations.Anna Airò La scrittura delle regole. Politica e istituzioni a Taranto nel Quattrocento, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Pasquale Arfé La Clavis Physicae II (316-529) di Honorius Augustodunensis. Studio ed edizione critica, Tesi di dottorato in Storia della filosofia medievale, Università degli Studi di Napoli "L'Orientale", 2005 Alessandro Azzimonti Scrittura agiografica e strutture di potere nell'Italia c...

  3. Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia.

    Science.gov (United States)

    Yang, Chunzhang; Zhuang, Zhengping; Fliedner, Stephanie M J; Shankavaram, Uma; Sun, Michael G; Bullova, Petra; Zhu, Roland; Elkahloun, Abdel G; Kourlas, Peter J; Merino, Maria; Kebebew, Electron; Pacak, Karel

    2015-01-01

    We have investigated genetic/pathogenetic factors associated with a new clinical entity in patients presenting with pheochromocytoma/paraganglioma (PHEO/PGL) and polycythemia. Two patients without hypoxia-inducible factor 2α (HIF2A) mutations, who presented with similar clinical manifestations, were analyzed for other gene mutations, including prolyl hydroxylase (PHD) mutations. We have found for the first time a germ-line mutation in PHD1 in one patient and a novel germ-line PHD2 mutation in a second patient. Both mutants exhibited reduced protein stability with substantial quantitative protein loss and thus compromised catalytic activities. Due to the unique association of patients' polycythemia with borderline or mildly elevated erythropoietin (EPO) levels, we also performed an in vitro sensitivity assay of erythroid progenitors to EPO and for EPO receptor (EPOR) expression. The results show inappropriate hypersensitivity of erythroid progenitors to EPO in these patients, indicating increased EPOR expression/activity. In addition, the present study indicates that HIF dysregulation due to PHD mutations plays an important role in the pathogenesis of these tumors and associated polycythemia. The PHD1 mutation appears to be a new member contributing to the genetic landscape of this novel clinical entity. Our results support the existence of a specific PHD1- and PHD2-associated PHEO/PGL-polycythemia disorder. • A novel germ-l i n e PHD1 mutation causing heochromocytoma/paraganglioma and polycythemia. • Increased EPOR activity and inappropriate hypersensitivity of erythroid progenitors to EPO.

  4. Development of non-intrusive monitoring techniques - ESDRED and TEM projects at Mont Terri and the Grimsel test site

    International Nuclear Information System (INIS)

    Breen, B.; Johnson, M.; Frieg, B.; Blechschmidt, I.; Manukyan, E.; Marelli, S.; Maurer, H.R.

    2008-01-01

    The EC Integrated Project, IP ESDRED (Engineering Studies and Demonstration of Repository Designs) was commissioned to establish a sound technical basis for demonstrating the safety of disposing of spent fuel and long-lived radioactive wastes in deep geological formations and to underpin the development of a common European view on the main issues related to the management and disposal of radioactive waste. The in situ development of non-intrusive monitoring techniques is included within the programme as an important component of the overall ESDRED programme. Monitoring will play an important role in providing information to the repository operator and to society in general and to support decision-making about if and when, to move from one phase to the next. The challenges, when constructing engineered barrier systems (EBS) to isolate the waste, is the ability to monitor the waste and the barriers, once isolated. Conventional monitoring systems depend upon wires or cable s to transfer information from the monitoring sensors outside the barriers. Monitoring sensors also have a limited lifetime and new sensors cannot be emplaced without disturbing the barrier. The development of non-intrusive monitoring systems which do not rely upon 'hard-wired' connection, thus providing the opportunity for continued monitoring after isolation. The ESDRED partners developed a programme utilising cross-hole seismic tomography to monitor an experimental demonstration by Nagra at Mont Terri Underground Research Laboratory (URL). The work programme includes PhD studies to conduct full seismic waveform analysis and to develop algorithms to address natural anisotropy in the Opalinus clay at Mont Terri. Following on from the ESDRED developments, some of ESDRED partner organisations identified a further opportunity for developing in situ monitoring techniques utilising the construction and testing programme of a low pH shotcrete plug being constructed in granite at the Grimsel Test Site

  5. Microbial investigations in Opalinus clay from Mont Terri and in Callovo-Oxfordian argillite from Meuse/Haute-Marne; Caracterisation microbiologique de l'argile a opalinus du Mont Terri et de l'argilite du callovo-oxfordien de Meuse/Haute-Marne

    Energy Technology Data Exchange (ETDEWEB)

    Poulain, S

    2006-12-15

    The subject of this Ph.D. thesis deals with research achieved in the context of the Axis 2 of the law Bataille voted on December 30, 1991 about the possibility of building a deep geological repository for medium or high activity and long living nuclear waste. Nearby such a site, some microorganisms may influence the mobility of radionuclides coming from the waste canisters. This work consisted in looking for autochthonous microorganisms in the Opalinus clay formation from Mont Terri (Switzerland) and in the Callovo-Oxfordian argillite from Meuse/Haute-Marne (France). Microbial Investigations in these unknown unperturbed environments suggested very low microbial densities in the clayey sediments. However, new bacterial species could be isolated from those samples. In addition, a part of the allochthonous population, which has been introduced by air and human activity, could be identified in the Meuse/Haute-Marne underground research laboratory. (author)

  6. Microbial investigations in Opalinus clay from Mont Terri and in Callovo-Oxfordian argillite from Meuse/Haute-Marne; Caracterisation microbiologique de l'argile a opalinus du Mont Terri et de l'argilite du callovo-oxfordien de Meuse/Haute-Marne

    Energy Technology Data Exchange (ETDEWEB)

    Poulain, S

    2006-12-15

    The subject of this Ph.D. thesis deals with research achieved in the context of the Axis 2 of the law Bataille voted on December 30, 1991 about the possibility of building a deep geological repository for medium or high activity and long living nuclear waste. Nearby such a site, some microorganisms may influence the mobility of radionuclides coming from the waste canisters. This work consisted in looking for autochthonous microorganisms in the Opalinus clay formation from Mont Terri (Switzerland) and in the Callovo-Oxfordian argillite from Meuse/Haute-Marne (France). Microbial Investigations in these unknown unperturbed environments suggested very low microbial densities in the clayey sediments. However, new bacterial species could be isolated from those samples. In addition, a part of the allochthonous population, which has been introduced by air and human activity, could be identified in the Meuse/Haute-Marne underground research laboratory. (author)

  7. Mont-Terri heater test: design and preliminary results

    International Nuclear Information System (INIS)

    Garcia-Sineriz, J.L.; Fuentes, J.L.; Mayor, J.C.; Huertas, F.

    2003-01-01

    Safety and long-term behaviour of underground permanent repositories depend on a combination of several engineered and geological barriers. The properties of the geological barriers are the natural conditions of the formation, while the performance of the engineered barriers is a result of their design and construction. The properties of the engineered barriers are deeply influenced by the interactions between both geological and engineered barriers in response to the conditions expected in a high level waste repository. These interactions need to be identified and fully understood to allow their input in models describing the behaviour of the near field to predict reliably the long-term performance and safety of a repository. The Heating Experiment (HE) project, which is taking place at the Mont-Terri underground laboratory in Switzerland, is conceived as a research project to learn more about the coupled thermo-hydro-mechanical processes in a clay formation around a heat source similar to those in a potential repository, with special emphasis on the interaction between the clay host rock and the bentonite buffer that is part of the engineered barrier, under saturated conditions. This project is co-funded by the European Commission and performed as part of the fifth EURATOM framework programme, key action Nuclear Fission (1998-2002). For that purpose, a central vertical borehole of 300 mm diameter and 7 m deep was drilled and an electrical heater surrounded with a Spanish bentonite buffer was installed inside. More than seventeen boreholes were instrumented for measuring parameters such as temperatures, total pressures, radial displacements, gas/water release and for performing geo-electric tomography. A total of 112 instruments were installed. The complexity of the issues involved requires a multi-partner approach and there exists a mutual interest of national research organisations to co-operate on a European level: two national agencies, which are responsible

  8. A PhD is a PhD is a PhD

    OpenAIRE

    Ostrow, Deborah Anne

    2017-01-01

    A PhD is a PhD is a PhD is a practice-based project that interrogates the process of an artist undertaking PhD research under established criteria. It consists of an exegesis, an original screenplay, and a digital film made for online viewing, with images drawn from a range of documentaries and films found on YouTube. They have been dissected, re-assembled and then re-embedded to YouTube. The source material covers topics such as medicalization of madness, the conspicuous appropriation of uni...

  9. On the contemporary – and contemporary art history. A review of Terry Smith, What Is Contemporary Art

    Directory of Open Access Journals (Sweden)

    Anthony Gardner

    2011-06-01

    Full Text Available This analysis of Terry Smith’s 'What Is Contemporary Art?' evaluates Smith’s ongoing project to theorise contemporary art around the theme of multiple, interconnected temporalities. It questions how this ‘contemporaneity’ differs from the classic teleologism of modernism and postmodern relativism and suggests that Smith’s categories may be valuable for understanding other cultural areas, such as contemporary music. It then raises methodological problems associated with charting the terrain of contemporary art and how they overlap with economic considerations, arguing that the task implies particular forms of privilege that may threaten the autonomy of critical analysis, but that Smith’s work goes some way toward exposing this problem.

  10. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-06-01

    Full Text Available Report of PhD Dissertations. Francesco Barone Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004   Laura Berti Ceroni Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.   Marco Bicchierai Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004   Emanuela Garimberti Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004   Lorenzo Tanzini Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004   Stefania Tarquini Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

  11. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2010-06-01

    Full Text Available Report of PhD dissertations. Andrea Brugnoli Una storia locale: l’organizzazione del territorio veronese nel medioevo: trasformazioni della realtà e schemi notarili (IX-metà XII secolo, Tesi di dottorato di ricerca in Scienze Storiche e Antropologiche (XXII ciclo, Università degli Studi di Verona, 2010   Luca Filangieri Famiglie e gruppi dirigenti a Genova (secoli XII-metà XIII, Tesi di dottorato di ricerca in Storia medievale (XXII ciclo, Università degli Studi di Firenze, 2010   Jakub Kujawi ski Wernakularna kolekcja historiograficzna z rękopisu francuskiego nr 688 z Biblioteki Narodowej w Paryżu. Studium źródłoznawcze (La raccolta dei volgarizzamenti delle opere storiografiche nel manoscritto francese 688 della Biblioteca Nazionale di Parigi, Tesi di dottorato, Università “Adam Mickiewicz”, Facoltà di Storia, Pozna, a.a. 2009/2010   Marta Longhi I signori “de Radicata”. Strategie di affermazione familiare e patrimoniale nel Piemonte dei secoli XII-XIV, Tesi di dottorato di ricerca in Istituzioni, Società, Religioni dal Tardo Antico alla fine del Medioevo (XX ciclo, Università di Torino, 2008

  12. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-06-01

    Full Text Available Reporto of PhD Dissertations.   Mario Dalle Carbonare Società, potere e clientele nell’Irlanda altomedievale (secoli V-IX, Tesi di dottorato di ricerca in Storia sociale europea, Università "Ca' Foscari" di Venezia, 2003 Vieri Mazzoni La legislazione antighibellina e la politica oligarchica della Parte Guelfa di Firenze nel secondo Trecento (1347-1378, Tesi di dottorato di ricerca in Storia Medievale (ciclo XII, Università degli Studi di Firenze   Alma Poloni Pisa dalle origini del movimento popolare alla discesa di Ludovico il Bavaro. I gruppi dirigenti cittadini tra continuità e trasformazione, Tesi di dottorato di ricerca in Storia dell'Europa nel medioevo, Università degli studi di Pisa, 2003   Andrea Puglia Potere marchionale, amministrazione del territorio, società locali dalla morte di Ugo di Tuscia a Guelfo VI di Baviera (1001-1160, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Milano, 2003

  13. Why Students in Catholic Secondary Schools Should Study Pope John XXIII's Encyclical, "Pacem in Terris" (1963)

    Science.gov (United States)

    Sweeney, James

    2015-01-01

    Pope John XXIII's final encyclical on the subject of peace, "Pacem in Terris," written after the Cuban missile crisis which he helped to resolve, is an extended treatment of the basic principles of political morality and particularly significant for its adoption--the first time by the Catholic Church--of the discourse of human rights.…

  14. Less Government Is Not the Answer: Response to John Chubb and Terry Moe.

    Science.gov (United States)

    Shannon, Thomas A.

    1991-01-01

    Disagrees with John Chubb and Terry Moe's proposal to manage public education according to market principles. America's hope for education is in the hands of the people, through participatory, accountable, and representative governance, not in the vagaries and disorder of the economic marketplace. Public schools and the economic marketplace must…

  15. Cotton/polyester and cotton/nylon warp knitted terry cloth: Why ...

    African Journals Online (AJOL)

    Administrator

    1994:68) and has the added advantage of enhanced durability because of the synthetic component that can be incorporated into the structure (Kadolph &. Langford, 2002:41). In practice, the ground yarns of warp knitted terry cloth fabrics often differ in composi- tion to the yarns of the pile (Miller, 1992:109, Wooten,. 1979).

  16. Astronaut Terry J. Hart in training session RMS for STS-2 bldg 29

    Science.gov (United States)

    1981-01-01

    Astronaut Terry J. Hart in training session with the Remote Manipulator System (RMS) for STS-2 bldg 29. Views show Truly working at the command console while watching out the windows. Karen Ehlers, an RMS procedures specialist, can be seen at left side of frame while Astronaut Sally Ride waits on right for her time at the RMS.

  17. Industrial PhD report: Sustainable Innovation

    DEFF Research Database (Denmark)

    Olesen, Gitte Gylling Hammershøj

    2011-01-01

    Erhvervs PhD rapport udarbejdet i tilknytning til Erhvervs PhD kurset der er obligatorisk for Erhvervs PhD studerende. Rapporten omhandler relationer melllem den akademiske verden og industrien i sammenhæng med PhD projektet, betragtet og analyseret gennem teori om bæredygtig innovation....

  18. Applying squeezing technique to clay-rocks: lessons learned from ten years experiments at Mont Terri

    International Nuclear Information System (INIS)

    Fernandez, A. M.; Melon, A.; Sanchez-Ledesma, D.M.; Tournassat, C.; Gaucher, E.; Astudillo, J.; Vinsot, A.

    2012-01-01

    Document available in extended abstract form only. Argillaceous formations of low permeability are considered in several countries as potential host rocks for the disposal of high level radioactive wastes (HLRW). In order to determine their suitability for waste disposal, evaluations of the hydro-geochemistry and transport mechanisms from such geologic formations to the biosphere must be undertaken. The migration of radionuclides through the geosphere will occur predominantly in the aqueous phase, and hence the pore water chemistry plays an important role in determining ion diffusion characteristics in argillaceous formations. Consequently, a great effort has been made to characterise the pore water chemistry in clay-rocks formations. In the last 10 years various techniques were developed for determining pore water composition of clay-rocks including both direct and indirect methods: 1) In situ pore water sampling (water and gas) from sealed boreholes (Pearson et al., 2003; Vinsot et al. 2008); 2) Laboratory pore water sampling from unaltered core samples by the squeezing technique at high pressures (Fernandez et al., 2009); and 3) Characterization of the water chemistry by geochemical modelling (Gaucher et al. 2009). Pore water chemistry in clay-rocks and extraction techniques were documented and reviewed in different studies (Sacchi et al., 2001). Recovering pristine pore water from low permeable and low water content systems is very difficult and sometimes impossible. Besides, uncertainties are associated to each method used for the pore water characterization. In this paper, a review about the high pressure squeezing technique applied to indurate clay-rocks was performed. For this purpose, the experimental work on Opalinus Clay at the Mont Terri Research Laboratory during the last ten years was evaluated. A complete discussion was made about different issues such as: a) why is necessary to obtain the pore water by squeezing in the context of radioactive waste

  19. The Mont Terri rock laboratory: International research in the Opalinus Clay

    International Nuclear Information System (INIS)

    Bossart, P.

    2015-01-01

    This article reports on a visit made to the rock laboratory in Mont Terri, Switzerland, where research is being done concerning rock materials that can possibly be used for the implementation of repositories for nuclear wastes. Emphasis is placed on the project’s organisation, rock geology and on-going experiments. International organisations also involved in research on nuclear waste repositories are listed. The research facilities in tunnels built in Opalinus Clay at the Mont Terri site are described. The geology of Opalinus Clay and the structures found in the research tunnels are discussed, as is the hydro-geological setting. The research programme and various institutions involved are listed and experiments carried out are noted. The facilities are now also being used for research on topics related to carbon sequestration

  20. GRS' research on clay rock in the Mont Terri underground laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Wieczorek, Klaus; Czaikowski, Oliver [Gesellschaft fuer Anlagen- und Reaktorsicherheit gGmbH, Braunschweig (Germany)

    2016-07-15

    For constructing a nuclear waste repository and for ensuring the safety requirements are met over very long time periods, thorough knowledge about the safety-relevant processes occurring in the coupled system of waste containers, engineered barriers, and the host rock is indispensable. For respectively targeted research work, the Mont Terri rock laboratory is a unique facility where repository research is performed in a clay rock environment. It is run by 16 international partners, and a great variety of questions are investigated. Some of the work which GRS as one of the Mont Terri partners is involved in is presented in this article. The focus is on thermal, hydraulic and mechanical behaviour of host rock and/or engineered barriers.

  1. Hydro-mechanical evolution of the EDZ as transport path for radionuclides and gas: insights from the Mont Terri rock laboratory (Switzerland)

    International Nuclear Information System (INIS)

    Paul Marschall, P.; Giger, S.; La Vassière De, R.

    2017-01-01

    The excavation damaged zone (EDZ) around the backfilled underground structures of a geological repository represents a release path for radionuclides, which needs to be addressed in the assessment of long-term safety. Additionally, the EDZ may form a highly efficient escape route for corrosion and degradation gases, thus limiting the gas overpressures in the backfilled repository structures. The efficiency of this release path depends not only on the shape and extent of the EDZ, but also on the self-sealing capacity of the host rock formation and the prevailing state conditions, such as in situ stresses and pore pressure. The hydro-mechanical and chemico-osmotic phenomena associated with the formation and temporal evolution of the EDZ are complex, thus precluding a detailed representation of the EDZ in conventional modelling tools for safety assessment. Therefore, simplified EDZ models, able to mimic the safety-relevant functional features of the EDZ in a traceable manner are required. In the framework of the Mont Terri Project, a versatile modelling approach has been developed for the simulation of flow and transport processes along the EDZ with the goal of capturing the evolution of hydraulic significance of the EDZ after closure of the backfilled underground structures. The approach draws on both empirical evidence and experimental data, collected in the niches and tunnels of the Mont Terri rock laboratory. The model was benchmarked with a data set from an in situ self-sealing experiment at the Mont Terri rock laboratory. This paper summarises the outcomes of the benchmark exercise that comprises relevant empirical evidence, experimental data bases and the conceptual framework for modelling the evolution of the hydraulic significance of the EDZ around a backfilled tunnel section during the entire re-saturation phase. (authors)

  2. Hydro-mechanical evolution of the EDZ as transport path for radionuclides and gas: insights from the Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Paul Marschall, P.; Giger, S. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); La Vassière De, R. [Agence Nationale pour la Gestion des Déchets Radioactifs ANDRA, Meuse Haute-Marne, Center RD 960, Bure (France); and others

    2017-04-15

    The excavation damaged zone (EDZ) around the backfilled underground structures of a geological repository represents a release path for radionuclides, which needs to be addressed in the assessment of long-term safety. Additionally, the EDZ may form a highly efficient escape route for corrosion and degradation gases, thus limiting the gas overpressures in the backfilled repository structures. The efficiency of this release path depends not only on the shape and extent of the EDZ, but also on the self-sealing capacity of the host rock formation and the prevailing state conditions, such as in situ stresses and pore pressure. The hydro-mechanical and chemico-osmotic phenomena associated with the formation and temporal evolution of the EDZ are complex, thus precluding a detailed representation of the EDZ in conventional modelling tools for safety assessment. Therefore, simplified EDZ models, able to mimic the safety-relevant functional features of the EDZ in a traceable manner are required. In the framework of the Mont Terri Project, a versatile modelling approach has been developed for the simulation of flow and transport processes along the EDZ with the goal of capturing the evolution of hydraulic significance of the EDZ after closure of the backfilled underground structures. The approach draws on both empirical evidence and experimental data, collected in the niches and tunnels of the Mont Terri rock laboratory. The model was benchmarked with a data set from an in situ self-sealing experiment at the Mont Terri rock laboratory. This paper summarises the outcomes of the benchmark exercise that comprises relevant empirical evidence, experimental data bases and the conceptual framework for modelling the evolution of the hydraulic significance of the EDZ around a backfilled tunnel section during the entire re-saturation phase. (authors)

  3. Terry Turbopump Expanded Operating Band Full-Scale Component and Basic Science Detailed Test Plan-Revision 2

    Energy Technology Data Exchange (ETDEWEB)

    Solom, Matthew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Severe Accident Analysis Dept.; Ross, Kyle [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Severe Accident Analysis Dept.; Cardoni, Jeffrey N. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Severe Accident Analysis Dept.; Osborn, Douglas [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Severe Accident Analysis Dept.

    2017-08-01

    This document details the milestone approach to define the true operating limitations (margins) of the Terry turbopump systems used in the nuclear industry for Milestone 3 (full-scale component experiments) and Milestone 4 (Terry turbopump basic science experiments) efforts. The overall multinational-sponsored program creates the technical basis to: (1) reduce and defer additional utility costs, (2) simplify plant operations, and (3) provide a better understanding of the true margin which could reduce overall risk of operations.

  4. Fifteen years of microbiological investigation in Opalinus Clay at the Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Leupin, O.X. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); Bernier-Latmani, R.; Bagnoud, A. [Swiss Federal Office of Technology EPFL, Lausanne (Switzerland); Moors, H.; Leys, N.; Wouters, K. [Belgian Nuclear Research Centre SCK-CEN, Mol (Belgium); Stroes-Gascoyne, S. [University of Saskatchewan, Saskatoon (Canada)

    2017-04-15

    Microbiological studies related to the geological disposal of radioactive waste have been conducted at the Mont Terri rock laboratory in Opalinus Clay, a potential host rock for a deep geologic repository, since 2002. The metabolic potential of microorganisms and their response to excavation-induced effects have been investigated in undisturbed and disturbed claystone cores and in pore- (borehole) water. Results from nearly 15 years of research at the Mont Terri rock laboratory have shown that microorganisms can potentially affect the environment of a repository by influencing redox conditions, metal corrosion and gas production and consumption under favourable conditions. However, the activity of microorganisms in undisturbed Opalinus Clay is limited by the very low porosity, the low water activity, and the largely recalcitrant nature of organic matter in the claystone formation. The presence of microorganisms in numerous experiments at the Mont Terri rock laboratory has suggested that excavation activities and perturbation of the host rock combined with additional contamination during the installation of experiments in boreholes create favourable conditions for microbial activity by providing increased space, water and substrates. Thus effects resulting from microbial activity might be expected in the proximity of a geological repository i.e., in the excavation damaged zone, the engineered barriers, and first containments (the containers). (authors)

  5. Fifteen years of microbiological investigation in Opalinus Clay at the Mont Terri rock laboratory (Switzerland)

    International Nuclear Information System (INIS)

    Leupin, O.X.; Bernier-Latmani, R.; Bagnoud, A.; Moors, H.; Leys, N.; Wouters, K.; Stroes-Gascoyne, S.

    2017-01-01

    Microbiological studies related to the geological disposal of radioactive waste have been conducted at the Mont Terri rock laboratory in Opalinus Clay, a potential host rock for a deep geologic repository, since 2002. The metabolic potential of microorganisms and their response to excavation-induced effects have been investigated in undisturbed and disturbed claystone cores and in pore- (borehole) water. Results from nearly 15 years of research at the Mont Terri rock laboratory have shown that microorganisms can potentially affect the environment of a repository by influencing redox conditions, metal corrosion and gas production and consumption under favourable conditions. However, the activity of microorganisms in undisturbed Opalinus Clay is limited by the very low porosity, the low water activity, and the largely recalcitrant nature of organic matter in the claystone formation. The presence of microorganisms in numerous experiments at the Mont Terri rock laboratory has suggested that excavation activities and perturbation of the host rock combined with additional contamination during the installation of experiments in boreholes create favourable conditions for microbial activity by providing increased space, water and substrates. Thus effects resulting from microbial activity might be expected in the proximity of a geological repository i.e., in the excavation damaged zone, the engineered barriers, and first containments (the containers). (authors)

  6. Preliminary Two-Phase Terry Turbine Nozzle Models for RCIC Off-Design Operation Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Haihua [Idaho National Lab. (INL), Idaho Falls, ID (United States); O' Brien, James [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-06-12

    This report presents the effort to extend the single-phase analytical Terry turbine model to cover two-phase off-design conditions. The work includes: (1) adding well-established two-phase choking models – the Isentropic Homogenous Equilibrium Model (IHEM) and Moody’s model, and (2) theoretical development and implementation of a two-phase nozzle expansion model. The two choking models provide bounding cases for the two-phase choking mass flow rate. The new two-phase Terry turbine model uses the choking models to calculate the mass flow rate, the critical pressure at the nozzle throat, and steam quality. In the divergent stage, we only consider the vapor phase with a similar model for the single-phase case by assuming that the liquid phase would slip along the wall with a much slower speed and will not contribute the impulse on the rotor. We also modify the stagnation conditions according to two-phase choking conditions at the throat and the cross-section areas for steam flow at the nozzle throat and at the nozzle exit. The new two-phase Terry turbine model was benchmarked with the same steam nozzle test as for the single-phase model. Better agreement with the experimental data is observed than from the single-phase model. We also repeated the Terry turbine nozzle benchmark work against the Sandia CFD simulation results with the two-phase model for the pure steam inlet nozzle case. The RCIC start-up tests were simulated and compared with the single-phase model. Similar results are obtained. Finally, we designed a new RCIC system test case to simulate the self-regulated Terry turbine behavior observed in Fukushima accidents. In this test, a period inlet condition for the steam quality varying from 1 to 0 is applied. For the high quality inlet period, the RCIC system behaves just like the normal operation condition with a high pump injection flow rate and a nominal steam release rate through the turbine, with the net addition of water to the primary system; for

  7. Paulette Gray, Ph.D.

    Science.gov (United States)

    Paulette S. Gray, Ph.D. is the Director for the Division of Extramural Activities (DEA). As the director of the division, she is responsible for the overall scientific, fiscal, and administrative management of the division, including broad strategic planning, development, implementation, and evaluation.

  8. PhD students and integrative research

    NARCIS (Netherlands)

    Fry, G.; Tress, B.; Tress, G.

    2006-01-01

    The training of PhD students is currently very dynamic and varies widely from place to place. We present some examples of this variation and comment on how it may affect the way PhD students cope with integrative studies. Our focus is on the training needs of PhD students studying integrative

  9. Gerald L. Epstein, PhD: director, center for science, technology, and security policy, American Association for the Advancement of Science (AAAS). Interview by Madeline Drexler.

    Science.gov (United States)

    Epstein, Gerald L

    2009-12-01

    Over his entire career, Gerald Epstein has toiled at the nexus of science, technology, and security. From 2003 to 2009, he was Senior Fellow for Science and Security at the Center for Strategic and International Studies Homeland Security Program, where he worked on reducing biological weapons threats, improving national preparedness, and easing potential tensions between the scientific research and national security communities. Epstein came to CSIS from the Institute for Defense Analyses. From 1996 to 2001, he served in the White House Office of Science and Technology Policy. And from 1983 to 1989, and again from 1991 until its demise in 1995, Epstein worked at the Congressional Office of Technology Assessment, where he directed a study on the proliferation of weapons of mass destruction, alongside research on other global security topics. A recognized expert in biological risk reduction, Epstein was actually trained as a physicist, having received SB degrees in physics and electrical engineering from MIT, and a PhD in physics from the University of California at Berkeley. How, then, did he come to study the evolving threat from bioterrorism? "What compelled me about bioterrorism was that it was a stellar example of a topic that would lead to a train wreck between the scientific community and the security community unless they figured out how to work together," he said. "The distance between a laboratory and a very large consequence event is a lot shorter in biology than in any other field. I got into bioterrorism to help make sure that the security community doesn't get so scared of the science that it shuts it down, and that the science community isn't so oblivious of security concerns that it pays no attention to them." Epstein spoke on November 6, 2009, with contributing writer Madeline Drexler, author of Emerging Epidemics: The Menace of New Infections (Penguin, 2009), an updated version of an earlier volume. Drexler holds a visiting appointment at the

  10. Litho- and biostratigraphy of the Opalinus Clay and bounding formations in the Mont Terri rock laboratory (Switzerland)

    International Nuclear Information System (INIS)

    Hostettler, B.; Reisdorf, A. G.; Jaeggi, D.

    2017-01-01

    A 250 m-deep inclined well, the Mont Terri BDB-1, was drilled through the Jurassic Opalinus Clay and its bounding formations at the Mont Terri rock laboratory (NW Switzerland). For the first time, a continuous section from (oldest to youngest) the topmost members of the Staffelegg Formation to the basal layers of the Hauptrogenstein Formation is now available in the Mont Terri area. We extensively studied the drill core for lithostratigraphy and biostratigraphy, drawing upon three sections from the Mont Terri area. The macropaleontological, micropaleontological, and palynostratigraphical data are complementary, not only spatially but they also cover almost all biozones from the Late Toarcian to the Early Bajocian. We ran a suite of geophysical logs to determine formational and intraformational boundaries based on clay content in the BDB-1 well. In the framework of an interdisciplinary study, analysis of the above-mentioned formations permitted us to process and derive new and substantial data for the Mont Terri area in a straightforward way. Some parts of the lithologic inventory, stratigraphic architecture, thickness variations, and biostratigraphic classification of the studied formations deviate considerably from occurrences in northern Switzerland that crop out further to the east. For instance, with the exception of the Sissach Member, no further lithostratigraphic subdivision in members is proposed for the Passwang Formation. Also noteworthy is that the ca. 130 m-thick Opalinus Clay in the BDB-1 core is 20 m thinner than that equivalent section found in the Mont Terri tunnel. The lowermost 38 m of the Opalinus Clay can be attributed chronostratigraphically solely to the Aalensis Zone (Late Toarcian). Deposition of the Opalinus Clay began at the same time farther east in northern Switzerland (Aalensis Subzone, Aalensis Zone), but in the Mont Terri area the sedimentation rate was two or three orders of magnitude higher. (authors)

  11. Litho- and biostratigraphy of the Opalinus Clay and bounding formations in the Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Hostettler, B. [Naturhistorisches Museum der Burgergemeinde Berne, Berne (Switzerland); Reisdorf, A. G. [Geologisch-Paläontologisches InstitutUniversität Basle, Basle (Switzerland); Jaeggi, D. [Swisstopo, Federal Office of Topography, Wabern (Switzerland); and others

    2017-04-15

    A 250 m-deep inclined well, the Mont Terri BDB-1, was drilled through the Jurassic Opalinus Clay and its bounding formations at the Mont Terri rock laboratory (NW Switzerland). For the first time, a continuous section from (oldest to youngest) the topmost members of the Staffelegg Formation to the basal layers of the Hauptrogenstein Formation is now available in the Mont Terri area. We extensively studied the drill core for lithostratigraphy and biostratigraphy, drawing upon three sections from the Mont Terri area. The macropaleontological, micropaleontological, and palynostratigraphical data are complementary, not only spatially but they also cover almost all biozones from the Late Toarcian to the Early Bajocian. We ran a suite of geophysical logs to determine formational and intraformational boundaries based on clay content in the BDB-1 well. In the framework of an interdisciplinary study, analysis of the above-mentioned formations permitted us to process and derive new and substantial data for the Mont Terri area in a straightforward way. Some parts of the lithologic inventory, stratigraphic architecture, thickness variations, and biostratigraphic classification of the studied formations deviate considerably from occurrences in northern Switzerland that crop out further to the east. For instance, with the exception of the Sissach Member, no further lithostratigraphic subdivision in members is proposed for the Passwang Formation. Also noteworthy is that the ca. 130 m-thick Opalinus Clay in the BDB-1 core is 20 m thinner than that equivalent section found in the Mont Terri tunnel. The lowermost 38 m of the Opalinus Clay can be attributed chronostratigraphically solely to the Aalensis Zone (Late Toarcian). Deposition of the Opalinus Clay began at the same time farther east in northern Switzerland (Aalensis Subzone, Aalensis Zone), but in the Mont Terri area the sedimentation rate was two or three orders of magnitude higher. (authors)

  12. ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

    CERN Multimedia

    Visual Media Office

    2013-01-01

    ISOLDE PH team, from left to right: Jennifer Weterings (user support), Susanne Kreim (research fellow), Marek Pfützner (scientific associate), Maria Garcia Borge (team leader), Elisa Rapisarda (research fellow) , Magdalena Kowalska (physics coordinator), Jan Kurcewicz (applied fellow), Monika Stachura (applied fellow). Not in the photo: Kara Lynch (PhD student).

  13. Terry Farrell between the gates: Part 2 - On postmodernism which refused to be deconstructed

    OpenAIRE

    Kolakowski, Marcin Mateusz

    1999-01-01

    “On postmodernism which refused to be deconstructed” Since 1991, the work of Terry Farrell has been connected with Asia. His saying “I am not afraid of looking backwards, as well as forwards” was again put to trial. There he had to join his contextual principles of architecture with the futuristic ambition of Asiatic investors: although the British Consulate in Hong Kong was called “very British”, its facade echoes both Hong Kong’s architecture and that of European Coliseum. Two wings of t...

  14. Twenty years of research at the Mont Terri rock laboratory: what we have learnt

    Energy Technology Data Exchange (ETDEWEB)

    Bossart, P. [Federal Office of Topography swisstopo, Wabern (Switzerland)

    2017-04-15

    The 20 papers in this Special Issue address questions related to the safe deep geological disposal of radioactive waste. Here we summarize the main results of these papers related to issues such as: formation of the excavation damaged zone, self-sealing processes, thermo-hydro-mechanical processes, anaerobic corrosion, hydrogen production and effects of microbial activity, and transport and retention processes of radionuclides. In addition, we clarify the question of transferability of results to other sites and programs and the role of rock laboratories for cooperation and training. Finally, we address the important role of the Mont Terri rock laboratory for the public acceptance of radioactive waste disposal. (author)

  15. Researcher Profile: An Interview with Sarah Asebedo, Ph.D.

    Directory of Open Access Journals (Sweden)

    Martie Gillen

    2016-12-01

    Full Text Available Sarah Asebedo, Ph.D., CFP®, is an Assistant Professor of Personal Financial Planning with Texas Tech University. With extensive financial planning practitioner experience, her goal is to connect research and financial planning practice with a focus on the relationship between psychological attributes, financial conflicts, and financial behavior. Her work has been published in the Journal of Financial Planning, Journal of Financial Therapy, Journal of Financial Counseling and Planning, and Financial Planning Review. Asebedo currently serves as President-Elect for the Financial Therapy Association. She earned her Ph.D. in Personal Financial Planning from Kansas State University.

  16. Purification and crystallization of Phd, the antitoxin of the phd/doc operon

    International Nuclear Information System (INIS)

    Garcia-Pino, Abel; Sterckx, Yann; Vandenbussche, Guy; Loris, Remy

    2010-01-01

    The antitoxin Phd from the phd/doc operon of bacteriophage P1 was crystallized in two distinct crystal forms. The antitoxin Phd from the phd/doc module of bacteriophage P1 was crystallized in two distinct crystal forms. Crystals of His-tagged Phd contain a C-terminally truncated version of the protein and diffract to 2.20 Å resolution. Crystals of untagged Phd purified from the Phd–Doc complex diffract to 2.25 Å resolution. These crystals are partially merohedrally twinned and contain the full-length version of the protein

  17. Conference on Stochastic Analysis and Applications 2014 : in honour of Terry Lyons

    CERN Document Server

    Hambly, Ben; Zariphopoulou, Thaleia

    2014-01-01

    Articles from many of the main contributors to recent progress in stochastic analysis are included in this volume, which provides a snapshot of the current state of the area and its ongoing developments. It constitutes the proceedings of the conference on "Stochastic Analysis and Applications" held at the University of Oxford and the Oxford-Man Institute during 23-27 September, 2013. The conference honored the 60th birthday of Professor Terry Lyons FLSW FRSE FRS, Wallis Professor of Mathematics, University of Oxford. Terry Lyons is one of the leaders in the field of stochastic analysis. His introduction of the notion of rough paths has revolutionized the field, both in theory and in practice.  Stochastic Analysis is the branch of mathematics that deals with the analysis of dynamical systems affected by noise. It emerged as a core area of mathematics in the late 20th century and has subsequently developed into an important theory with a wide range of powerful and novel tools, and with impressive applications ...

  18. A Test and Extension of Lane and Terry's (2000) Conceptual Model of Mood-Performance Relationships Using a Large Internet Sample.

    Science.gov (United States)

    Lane, Andrew M; Terry, Peter C; Devonport, Tracey J; Friesen, Andrew P; Totterdell, Peter A

    2017-01-01

    The present study tested and extended Lane and Terry (2000) conceptual model of mood-performance relationships using a large dataset from an online experiment. Methodological and theoretical advances included testing a more balanced model of pleasant and unpleasant emotions, and evaluating relationships among emotion regulation traits, states and beliefs, psychological skills use, perceptions of performance, mental preparation, and effort exerted during competition. Participants ( N = 73,588) completed measures of trait emotion regulation, emotion regulation beliefs, regulation efficacy, use of psychological skills, and rated their anger, anxiety, dejection, excitement, energy, and happiness before completing a competitive concentration task. Post-competition, participants completed measures of effort exerted, beliefs about the quality of mental preparation, and subjective performance. Results showed that dejection associated with worse performance with the no-dejection group performing 3.2% better. Dejection associated with higher anxiety and anger scores and lower energy, excitement, and happiness scores. The proposed moderating effect of dejection was supported for the anxiety-performance relationship but not the anger-performance relationship. In the no-dejection group, participants who reported moderate or high anxiety outperformed those reporting low anxiety by about 1.6%. Overall, results showed partial support for Lane and Terry's model. In terms of extending the model, results showed dejection associated with greater use of suppression, less frequent use of re-appraisal and psychological skills, lower emotion regulation beliefs, and lower emotion regulation efficacy. Further, dejection associated with greater effort during performance, beliefs that pre-competition emotions did not assist goal achievement, and low subjective performance. Future research is required to investigate the role of intense emotions in emotion regulation and performance.

  19. The Origin of The Piz Terri-Lunschania zone (Central Alps, Switzerland)

    Science.gov (United States)

    Galster, Federico; Stockli, Daniel

    2017-04-01

    The Piz Terri-Lunschania zone (PTLZ) represents a band of metasedimentary rocks embedded in a crucial knot at the NE border of the Lepontine dome, at the intersection of the Gotthard, Lucomagno, Simano, Adula and Grava nappes. Its origin and its position in the tectonostratigraphy of the Central Alps are still not completely understood. A better understanding of this sedimentary zone and its tectonic position could shed lights on the Helvetic-Penninic connection and facilitate the disentanglement of the Lepontine dome tectonics. In this study we combine structural and stratigraphic observations with detrital zircon (DZ) and detrital rutile (DR) U-Pb geochronology as well as mineral trace element data from Permian, Triassic and Jurassic sandstones. We compare these data with those from adjacent tectonic units and coeval strata in other portions of the Alpine chain. Maximal depositional ages, abrupt changes in provenances and stratigraphic correlations based on new DZ and DR U-Pb and trace element data allow for a better understanding of the sedimentary evolution of the Terri basin and its palaeogeographic position along the northern margin of the Alpine Tethys. In particular the DZ U-Pb signatures, with its abundant 260-280 Ma zircons and the scarcity of 290-350 Ma zircons, corroborates an Ultra-Adula origin of the PTLZ as proposed by Galster et al (2010; 2012) based on stratigraphic arguments and reinforces the notion of a Briançonnais influence on the stratigraphic record of this complex zone, a fact that has important tectonic and Palaeogeographic implications. Galster F, Cavargna-Sani M, Epard J-L, Masson H (2012) New stratigraphic data from the Lower Penninic between the Adula nappe and the Gotthard massif and consequences for the tectonics and the paleogeography of the Central Alps. Tectonophysics 579:37-55. doi: 10.1016/j.tecto.2012.05.029 Galster F, Epard J-L, Masson H (2010) The Soja and Luzzone-Terri nappes: Discovery of a Briançonnais element below the

  20. Mont Terri rock laboratory, 20 years of research: introduction, site characteristics and overview of experiments

    International Nuclear Information System (INIS)

    Bossart, P.; Bernier, F.; Birkholzer, J.

    2017-01-01

    Geologic repositories for radioactive waste are designed as multi-barrier disposal systems that perform a number of functions including the long-term isolation and containment of waste from the human environment, and the attenuation of radionuclides released to the subsurface. The rock laboratory at Mont Terri (canton Jura, Switzerland) in the Opalinus Clay plays an important role in the development of such repositories. The experimental results gained in the last 20 years are used to study the possible evolution of a repository and investigate processes closely related to the safety functions of a repository hosted in a clay rock. At the same time, these experiments have increased our general knowledge of the complex behaviour of argillaceous formations in response to coupled hydrological, mechanical, thermal, chemical, and biological processes. After presenting the geological setting in and around the Mont Terri rock laboratory and an overview of the mineralogy and key properties of the Opalinus Clay, we give a brief overview of the key experiments that are described in more detail in the following research papers to this Special Issue of the Swiss Journal of Geosciences. These experiments aim to characterise the Opalinus Clay and estimate safety-relevant parameters, test procedures, and technologies for repository construction and waste emplacement. Other aspects covered are: bentonite buffer emplacement, high-pH concrete-clay interaction experiments, anaerobic steel corrosion with hydrogen formation, depletion of hydrogen by microbial activity, and finally, release of radionuclides into the bentonite buffer and the Opalinus Clay barrier. In the case of a spent fuel/high-level waste repository, the time considered in performance assessment for repository evolution is generally 1 million years, starting with a transient phase over the first 10,000 years and followed by an equilibrium phase. Experiments dealing with initial conditions, construction, and waste

  1. Geological modeling of a fault zone in clay rocks at the Mont-Terri laboratory (Switzerland)

    Science.gov (United States)

    Kakurina, M.; Guglielmi, Y.; Nussbaum, C.; Valley, B.

    2016-12-01

    Clay-rich formations are considered to be a natural barrier for radionuclides or fluids (water, hydrocarbons, CO2) migration. However, little is known about the architecture of faults affecting clay formations because of their quick alteration at the Earth's surface. The Mont Terri Underground Research Laboratory provides exceptional conditions to investigate an un-weathered, perfectly exposed clay fault zone architecture and to conduct fault activation experiments that allow explore the conditions for stability of such clay faults. Here we show first results from a detailed geological model of the Mont Terri Main Fault architecture, using GoCad software, a detailed structural analysis of 6 fully cored and logged 30-to-50m long and 3-to-15m spaced boreholes crossing the fault zone. These high-definition geological data were acquired within the Fault Slip (FS) experiment project that consisted in fluid injections in different intervals within the fault using the SIMFIP probe to explore the conditions for the fault mechanical and seismic stability. The Mont Terri Main Fault "core" consists of a thrust zone about 0.8 to 3m wide that is bounded by two major fault planes. Between these planes, there is an assembly of distinct slickensided surfaces and various facies including scaly clays, fault gouge and fractured zones. Scaly clay including S-C bands and microfolds occurs in larger zones at top and bottom of the Mail Fault. A cm-thin layer of gouge, that is known to accommodate high strain parts, runs along the upper fault zone boundary. The non-scaly part mainly consists of undeformed rock block, bounded by slickensides. Such a complexity as well as the continuity of the two major surfaces are hard to correlate between the different boreholes even with the high density of geological data within the relatively small volume of the experiment. This may show that a poor strain localization occurred during faulting giving some perspectives about the potential for

  2. Micro-textures of Deformed Gouges by Friction Experiments of Mont Terri Main Fault, Switzerland

    Science.gov (United States)

    Aoki, K.; Seshimo, K.; Sakai, T.; Komine, Y.; Kametaka, M.; Watanabe, T.; Nussbaum, C.; Guglielmi, Y.

    2017-12-01

    Friction experiment was conducted on samples from the Main Fault of Mont Terri Rock Laboratory, Switzerland and then micro-textures of deformed gouges were observed using a scanning electron microscope JCM-6000 and JXA-8530F. Samples were taken at the depths of 47.2m and 37.3m of borehole BSF-1, and at 36.7m, 37.1m, 41.4m and 44.6m of borehole BSF-2, which were drilled from the drift floor at 260m depth from the surface. Friction experiment was conducted on above 6 samples using a rotary shear low to high-velocity friction apparatus at the Institute of Geology, China Earthquake Administration in Beijing at a normal stress of 3.95 to 4.0 MPa and at slip rates ranging 0.2 microns/s to 2.1mm/s. Cylindrical specimens of Ti-Al-V alloy, exhibiting similar behaviors as the host rock specimen, were used as rotary and stationary pistons of 40 mm diameter. A Teflon sleeve was used around the piston to confine the sample during the test. Main results are summarized as follows. 1) Mud rocks in Mont Terri drill holes (BFS-1, BFS-2) had steady-state or nearly steady-state friction coefficient μss in the range of 0.1 0.3 for wet gouges and 0. 5 0.7 for dry gouges. Friction coefficients of dry gouges were approximately twice as large as those of wet gouges. However, the fault rock (37.3 m, BFS-1) with scaly fabric showed no difference between wet and dry conditions : μss (wet): 0.50 0.77, μss (dry): 0.45 0.78. This is probably because the clay contents of this rock is less ( 33 %) than those in other rocks (67 73 %) (Shimamoto, 2017). 2) Deformed gouges are characterized by well-developed slip zones adjacent to the rotary and stationary pistons, accompanied by slickenside surfaces with clear striations. Such slickenside surfaces are similar to those developed in the drill core samples used in our experiments. 3) Multiple slip zones were observed in the 37.3m of BFS-1 and the 36.7m of BFS-2 samples under dry condition, suggesting that a slip occurred in the interior of the gouge

  3. Mont Terri rock laboratory, 20 years of research: introduction, site characteristics and overview of experiments

    Energy Technology Data Exchange (ETDEWEB)

    Bossart, P. [Swisstopo, Federal Office of Topography, Wabern (Switzerland); Bernier, F. [Federal Agency for Nuclear Control FANC, Brussels (Belgium); Birkholzer, J. [Lawrence Berkeley National Laboratory, Berkeley (United States); and others

    2017-04-15

    Geologic repositories for radioactive waste are designed as multi-barrier disposal systems that perform a number of functions including the long-term isolation and containment of waste from the human environment, and the attenuation of radionuclides released to the subsurface. The rock laboratory at Mont Terri (canton Jura, Switzerland) in the Opalinus Clay plays an important role in the development of such repositories. The experimental results gained in the last 20 years are used to study the possible evolution of a repository and investigate processes closely related to the safety functions of a repository hosted in a clay rock. At the same time, these experiments have increased our general knowledge of the complex behaviour of argillaceous formations in response to coupled hydrological, mechanical, thermal, chemical, and biological processes. After presenting the geological setting in and around the Mont Terri rock laboratory and an overview of the mineralogy and key properties of the Opalinus Clay, we give a brief overview of the key experiments that are described in more detail in the following research papers to this Special Issue of the Swiss Journal of Geosciences. These experiments aim to characterise the Opalinus Clay and estimate safety-relevant parameters, test procedures, and technologies for repository construction and waste emplacement. Other aspects covered are: bentonite buffer emplacement, high-pH concrete-clay interaction experiments, anaerobic steel corrosion with hydrogen formation, depletion of hydrogen by microbial activity, and finally, release of radionuclides into the bentonite buffer and the Opalinus Clay barrier. In the case of a spent fuel/high-level waste repository, the time considered in performance assessment for repository evolution is generally 1 million years, starting with a transient phase over the first 10,000 years and followed by an equilibrium phase. Experiments dealing with initial conditions, construction, and waste

  4. Mont Terri Project - Heater experiment, engineered barriers emplacement and ventilations tests. No 1 - Swiss Geological Survey, Bern, 2007

    International Nuclear Information System (INIS)

    Bossart, P.; Nussbaum, C.

    2007-01-01

    The international Mont Terri project started in January 1996. Research is carried out in the Mont Terri rock laboratory, an underground facility near the security gallery of the Mont Terri motorway tunnel (vicinity of St-Ursanne, Canton of Jura, Switzerland). The aim of the project is the geological, hydrogeological, geochemical and geotechnical characterisation of a clay formation, specifically of the Opalinus Clay. Twelve Partners from European countries and Japan participate in the project. These are ANDRA, BGR, CRIEPI, ENRESA, GRS, HSK, IRSN, JAEA, NAGRA, OBAYASHI, SCK.CEN and swisstopo. Since 2006, swisstopo acts as operator of the rock laboratory and is responsible for the implementation of the research programme decided by the partners. The three following reports are milestones in the research history of the Mont Terri project. It was the first time that an in-situ heating test with about 20 observation boreholes over a time span of several years was carried out in a clay formation. The engineered barrier emplacement experiment has been extended due to very encouraging measurement results and is still going on. The ventilation test was and is a challenge, especially in the very narrow microtunnel. All three projects were financially supported by the European Commission and the Swiss State Secretariat for Education and Research. The three important scientific and technical reports, which are presented in the following, have been provided by a number of scientists, engineers and technicians from the Partners, but also from national research organisations and private contractors. Many fruitful meetings where held, at the rock laboratory and at other facilities, not to forget the weeks and months of installation and testing work carried out by the technicians and engineers. The corresponding names and organisations are listed in detail in the reports. Special thanks are going to the co-ordinators of the three projects for their motivation of the team during

  5. Development and Implementation of Mechanistic Terry Turbine Models in RELAP-7 to Simulate RCIC Normal Operation Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Haihua [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zou, Ling [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zhang, Hongbin [Idaho National Lab. (INL), Idaho Falls, ID (United States); O' Brien, James Edward [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-09-01

    As part of the efforts to understand the unexpected “self-regulating” mode of the RCIC (Reactor Core Isolation Cooling) systems in Fukushima accidents and extend BWR RCIC and PWR AFW (Auxiliary Feed Water) operational range and flexibility, mechanistic models for the Terry turbine, based on Sandia’s original work [1], have been developed and implemented in the RELAP-7 code to simulate the RCIC system. In 2016, our effort has been focused on normal working conditions of the RCIC system. More complex off-design conditions will be pursued in later years when more data are available. In the Sandia model, the turbine stator inlet velocity is provided according to a reduced-order model which was obtained from a large number of CFD (computational fluid dynamics) simulations. In this work, we propose an alternative method, using an under-expanded jet model to obtain the velocity and thermodynamic conditions for the turbine stator inlet. The models include both an adiabatic expansion process inside the nozzle and a free expansion process outside of the nozzle to ambient pressure. The combined models are able to predict the steam mass flow rate and supersonic velocity to the Terry turbine bucket entrance, which are the necessary input information for the Terry turbine rotor model. The analytical models for the nozzle were validated with experimental data and benchmarked with CFD simulations. The analytical models generally agree well with the experimental data and CFD simulations. The analytical models are suitable for implementation into a reactor system analysis code or severe accident code as part of mechanistic and dynamical models to understand the RCIC behaviors. The newly developed nozzle models and modified turbine rotor model according to the Sandia’s original work have been implemented into RELAP-7, along with the original Sandia Terry turbine model. A new pump model has also been developed and implemented to couple with the Terry turbine model. An input

  6. The full-scale Emplacement (FE) Experiment at the Mont Terri URL

    International Nuclear Information System (INIS)

    Mueller, H.R.; Weber, H.P.; Koehler, S.; Vogt, T.; Vietor, T.

    2012-01-01

    Document available in extended abstract form only. The Full-Scale Emplacement (FE) Experiment at the Mont Terri underground research laboratory (URL) is a full-scale heater test in a clay-rich formation. It simulates the construction, waste emplacement and backfilling of a spent fuel (SF) / vitrified high-level waste (HLW) repository tunnel as realistically as possible. The entire experiment implementation as well as the post-closure THM(C) evolution will be monitored using several hundred sensors. These are distributed in the host rock in the near- and far-field, the tunnel lining, the engineered barrier system and on the heaters. The aim of this experiment is to investigate HLW repository-induced thermo-hydro-mechanical (THM) coupled effects on the host rock and the validation of existing coupled THM models. A further aim is the verification of the technical feasibility of constructing a 50 m repository section at full scale with all relevant components using standard industrial equipment. Finally, the experiment will demonstrate the canister and buffer emplacement procedures for underground conditions based on the Swiss disposal concept. Experimental layout The FE experiment is based on the Swiss disposal concept for SF / HLW. The 50 m long test gallery, at the end of the former MB test tunnel in the Mont Terri URL, will be realised with a diameter of approx. 3 m. In the experiment gallery, 3 heaters with dimensions similar to those of waste canisters will be emplaced on top of abutments built of bentonite blocks. The remaining space will be backfilled with compacted bentonite pellets. The experiment will be sealed off towards the start niche with a concrete plug holding the buffer in place and reducing air and water fluxes. The first scoping calculations and design modelling for the 'far-field' instrumentation have been completed; these works have been carried out using CodeBRIGHT and the multiphase flow simulator TOUGH2. With an initial heat output of 1500 W

  7. Performance of the Opalinus Clay under thermal loading: experimental results from Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Gens, A. [Universitat Politència de Catalunya, Barcelona (Spain); Wieczorek, K. [Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) GmbH, Braunschweig (Germany); Gaus, I. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); and others

    2017-04-15

    The paper presents an overview of the behaviour of Opalinus Clay under thermal loading as observed in three in situ heating tests performed in the Mont Terri rock laboratory: HE-B, HE-D and HE-E. The three tests are summarily described; they encompass a broad range of test layouts and experimental conditions. Afterwards, the following topics are examined: determination of thermal conductivity, thermally-induced pore pressure generation and thermally-induced mechanical effects. The mechanisms underlying pore pressure generation and dissipation are discussed in detail and the relationship between rock damage and thermal loading is examined using an additional in situ test: SE-H. The paper concludes with an evaluation of the various thermo-hydro-mechanical (THM) interactions identified in the heating tests. (authors)

  8. Urbanism PhD Research 2008 - 2010

    NARCIS (Netherlands)

    Smit, M.; Van der Hoeven, F.D.; Brand, N.; Van der Burg, L.; Çal??kan, O.; Tan, E.R.; Wang, C.Y.; Zhou, J.

    2009-01-01

    To ensure the quality of the Ph.D. research the Department introduced a special procedure for periodic evaluation: after a period of nine months the potential Ph.D. candidates are asked to present their research design, theoretical framework and methodological approach to the members of the

  9. Geochemical signature of paleofluids in microstructures from Main Fault in the Opalinus Clay of the Mont Terri rock laboratory, Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Clauer, N. [Laboratoire d’Hydrologie et de Géochimie de Strasbourg (CNRS-UdS), Strasbourg (France); Techer, I. [Equipe Associée, Chrome, Université de Nîmes, Nîmes (France); Nussbaum, Ch. [Swiss Geological Survey, Federal Office of Topography Swisstopo, Wabern (Switzerland); Laurich, B. [Structural Geology, Tectonics and Geomechanics, RWTH Aachen University, Aachen (Germany); Laurich, B. [Federal Institute for Geosciences and Natural Resources BGR, Hannover (Germany)

    2017-04-15

    The present study reports on elemental and Sr isotopic analyses of calcite and associated celestite infillings of various microtectonic features collected mostly in the Main Fault of the Opalinus Clay from Mont Terri rock laboratory. Based on a detailed microstructural description of veins, slickensides, scaly clay aggregates and gouges, the geochemical signatures of the infillings were compared to those of the leachates from undeformed Opalinus Clay, and to the calcite from veins crosscutting Hauptrogenstein, Passwang and Staffelegg Formations above and below the Opalinus Clay. Vein calcite and celestite from Main Fault yield identical {sup 87}Sr/{sup 86}Sr ratios that are also close to those recorded in the Opalinus Clay matrix inside the Main Fault, but different from those of the diffuse Opalinus Clay calcite outside the fault. These varied {sup 87}Sr/{sup 86}Sr ratios of the diffuse calcite evidence a lack of interaction among the associated connate waters and the flowing fluids characterized by a homogeneous Sr signature. The {sup 87}Sr/{sup 86}Sr homogeneity at 0.70774 ± 0.00001 (2σ) for the infillings of most microstructures in the Main Fault, as well as of veins from nearby limestone layer and sediments around the Opalinus Clay, claims for an 'infinite' homogeneous marine supply, whereas the gouge infillings apparently interacted with a fluid chemically more complex. According to the known regional paleogeographic evolution, two seawater supplies were inferred and documented in the Delémont Basin: either during the Priabonian (38-34 Ma ago) from western Bresse graben, and/or during the Rupelian (34-28 Ma ago) from northern Rhine Graben. The Rupelian seawater that yields a mean {sup 87}Sr/{sup 86}Sr signature significantly higher than those of the microstructural infillings seems not to be the appropriate source. Alternatively, Priabonian seawater yields a mean {sup 87}Sr/{sup 86}Sr ratio precisely matching that of the leachates from diffuse

  10. Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study.

    Directory of Open Access Journals (Sweden)

    Dimitrios Spiliotopoulos

    Full Text Available PHD fingers represent one of the largest families of epigenetic readers capable of decoding post-translationally modified or unmodified histone H3 tails. Because of their direct involvement in human pathologies they are increasingly considered as a potential therapeutic target. Several PHD/histone-peptide structures have been determined, however relatively little information is available on their dynamics. Studies aiming to characterize the dynamic and energetic determinants driving histone peptide recognition by epigenetic readers would strongly benefit from computational studies. Herein we focus on the dynamic and energetic characterization of the PHD finger subclass specialized in the recognition of histone H3 peptides unmodified in position K4 (H3K4me0. As a case study we focused on the first PHD finger of autoimmune regulator protein (AIRE-PHD1 in complex with H3K4me0. PCA analysis of the covariance matrix of free AIRE-PHD1 highlights the presence of a "flapping" movement, which is blocked in an open conformation upon binding to H3K4me0. Moreover, binding free energy calculations obtained through Molecular Mechanics/Poisson-Boltzmann Surface Area (MM/PBSA methodology are in good qualitative agreement with experiments and allow dissection of the energetic terms associated with native and alanine mutants of AIRE-PHD1/H3K4me0 complexes. MM/PBSA calculations have also been applied to the energetic analysis of other PHD fingers recognizing H3K4me0. In this case we observe excellent correlation between computed and experimental binding free energies. Overall calculations show that H3K4me0 recognition by PHD fingers relies on compensation of the electrostatic and polar solvation energy terms and is stabilized by non-polar interactions.

  11. Ventilation test at Mont Terri. Geoelectric monitoring of the opalinus clay desaturation. Phase 2

    International Nuclear Information System (INIS)

    Wieczorek, Klaus; Zhang, Chun-Liang; Rothfuchs, Tilmann

    2008-04-01

    Between December 2001 and May 2004, a ventilation experiment (VE) was performed in the Mont Terri Underground Research Laboratory (URL) and co-financed by the Commission of the European Communities. The objective was to investigate the desaturation of consolidated clay formations in consequence of the ventilation of underground openings of a repository in such a formation. The results of the geoelectric measurements performed in the second phase of the Mont Terri ventilation test can be summarized as follows: Geoelectric tomography has been found suitable for monitoring ventilation-induced saturation changes in the Opalinus clay. During ventilation with dry air a desaturation down to below 50% could be detected in both desaturation cycles. The desaturated zone extends less than 0.5 m into the rock around the microtunnel. During the second resaturation phase, ventilation with humid air led to quick resaturation at the tunnel surface, while resaturation of the rock mass took months. The still ongoing third resaturation phase seems to imply that resaturation of the rock mass may take years with no air circulation in the tunnel. The laboratory investigations on the Opalinus clay included the determination of water retention capacity, swelling pressure, free swelling/shrinking strains induced by moisture changes, and response of normal and large hollow clay samples to the ventilation of the central boreholes at different air humidity values. The Opalinus clay has a high water absorption capacity. The amount of water uptake in unconstraint conditions is much higher than the water content in the naturally confined state, indicating that the pore water in the natural clay rock is predominantly bound on clay minerals. The swelling pressure induced by wetting with vapour is very close to the major lithostatic stress at the sampling location. Water uptake from vapour causes a large free expansion of up to 12% over 8 months and even a breakdown along bedding planes. Release of

  12. End-of-Life Issues in the United States after Terri Schiavo: Implications for Social Work Practice

    Directory of Open Access Journals (Sweden)

    Darrel Montero

    2011-09-01

    Full Text Available The very public death of Terri Schiavo in 2005 alerted Americans to what is a growing ethical, medical, and social crisis: the status of end-of-life issues and decisions in the United States. Currently, Oregon is the only state to give terminally ill patients the right to end their lives, with physicians’ help, if they so choose. Public opinion data from 1977 to the present show that Americans support greater rights for individuals facing end-of-life decisions--up to and including physician-assisted suicide and euthanasia. This paper considers the status of end-of-life issues in the United States after Terri Schiavo’s death and examines the opportunities for advocacy by social workers who serve clients and families encountering this complex and controversial issue.

  13. Partnership for development: A peer mentorship model for PhD students.

    Science.gov (United States)

    Lewinski, Allison A; Mann, Tara; Flores, Dalmacio; Vance, Ashlee; Bettger, Janet Prvu; Hirschey, Rachel

    Formal mentoring relationships socialize Doctor of Philosophy (PhD) students to their current and future roles as nursing scholars. Despite formal mentoring, some students may desire or benefit from additional mentoring in an informal setting. Informal mentoring complements the one-to-one relationship students develop with a primary faculty mentor or dissertation chair. This manuscript describes the development, implementation, and evaluation of a student-driven, peer mentorship model, titled Partnership for Development. This small group, peer mentorship model was implemented in a PhD program at a School of Nursing during an academic year. Five student peer facilitators organized a total of 32 PhD students, 2 post-doctoral associates, and invited 5 faculty to participate. Data includes pre- and post-implementation surveys completed by the students and peer facilitator field notes. Student reported post-participation benefits included: getting to know faculty in an informal setting (n=6), socializing with students from other cohorts (n=6), and obtaining a sense of camaraderie with other PhD students (n=5). We recommend peer mentorship for other PhD programs as a way to socialize PhD students into the role of nurse scientist and assist students during their tenure as a PhD student. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Natural gas extraction and artificial gas injection experiments in Opalinus Clay, Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Vinsot, A.; Lundy, M. [Agence Nationale pour la Gestion des Déchets Radioactifs ANDRA, Meuse Haute-Marne Center, Bure (France); Appelo, C.A.J. [Dr C.A.J. Appelo, Hydrochemical Consultant, Amsterdam (Netherlands); and others

    2017-04-15

    Two experiments have been installed at Mont Terri in 2004 and 2009 that allowed gas circulation within a borehole at a pressure between 1 and 2 bar. These experiments made it possible to observe the natural gases that were initially dissolved in pore-water degassing into the borehole and to monitor their content evolution in the borehole over several years. They also allowed for inert (He, Ne) and reactive (H{sub 2}) gases to be injected into the borehole with the aim either to determine their diffusion properties into the rock pore-water or to evaluate their removal reaction kinetics. The natural gases identified were CO{sub 2}, light alkanes, He, and more importantly N{sub 2}. The natural concentration of four gases in Opalinus Clay pore-water was evaluated at the experiment location: N{sub 2} 2.2 mmol/L ± 25%, CH{sub 4} 0.30 mmol/L ± 25%, C{sub 2}H{sub 6} 0.023 mmol/L ± 25%, C{sub 3}H{sub 8} 0.012 mmol/L ± 25%. Retention properties of methane, ethane, and propane were estimated. Ne injection tests helped to characterize rock diffusion properties regarding the dissolved inert gases. These experimental results are highly relevant towards evaluating how the fluid composition could possibly evolve in the drifts of a radioactive waste disposal facility. (authors)

  15. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.

    Science.gov (United States)

    Wang, Gang G; Song, Jikui; Wang, Zhanxin; Dormann, Holger L; Casadio, Fabio; Li, Haitao; Luo, Jun-Li; Patel, Dinshaw J; Allis, C David

    2009-06-11

    Histone H3 lysine 4 methylation (H3K4me) has been proposed as a critical component in regulating gene expression, epigenetic states, and cellular identities1. The biological meaning of H3K4me is interpreted by conserved modules including plant homeodomain (PHD) fingers that recognize varied H3K4me states. The dysregulation of PHD fingers has been implicated in several human diseases, including cancers and immune or neurological disorders. Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models. In these processes, a PHD finger that specifically recognizes H3K4me3/2 marks was essential for leukaemogenesis. Mutations in PHD fingers that abrogated H3K4me3 binding also abolished leukaemic transformation. NUP98-PHD fusion prevented the differentiation-associated removal of H3K4me3 at many loci encoding lineage-specific transcription factors (Hox(s), Gata3, Meis1, Eya1 and Pbx1), and enforced their active gene transcription in murine haematopoietic stem/progenitor cells. Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells. Collectively, our studies represent, to our knowledge, the first report that deregulation of the PHD finger, an 'effector' of specific histone modification, perturbs the epigenetic dynamics on developmentally critical loci, catastrophizes cellular fate decision-making, and even causes oncogenesis during mammalian development.

  16. Excavation Induced Hydraulic Response of Opalinus Clay - Investigations of the FE-Experiment at the Mont Terri URL in Switzerland

    Science.gov (United States)

    Vogt, T.; Müller, H. R.; Garitte, B.; Sakaki, T.; Vietor, T.

    2013-12-01

    The Full-Scale Emplacement (FE) Experiment at the Mont Terri underground research laboratory in Switzerland is a full-scale heater test in a clay-rich formation (Opalinus Clay). Based on the Swiss disposal concept it simulates the construction, emplacement, backfilling, and post-closure thermo-hydro-mechanical (THM) evolution of a spent fuel / vitrified high-level waste (SF / HLW) repository tunnel in a realistic manner. The main aim of this experiment is to investigate SF / HLW repository-induced THM coupled effects mainly in the host rock but also in the engineered barrier system (EBS), which consists of bentonite pellets and blocks. A further aim is to gather experience with full-scale tunnel construction and associated hydro-mechanical (HM) processes in the host rock. The entire experiment implementation (in a 50 m long gallery with approx. 3 m diameter) as well as the post-closure THM evolution will be monitored using a network of several hundred sensors (state-of-the-art sensors and measurement systems as well as fiber-optic sensors). The sensors are distributed in the host rock's near- and far-field, the tunnel lining, the EBS, and on the heaters. The heater emplacement and backfilling has not started yet, therefore only the host rock instrumentation is installed at the moment and is currently generating data. We will present the instrumentation concept and rationale as well as the first monitoring results of the excavation and ventilation phase. In particular, we investigated the excavation induced hydraulic response of the host rock. Therefore, the spatiotemporal evolution of porewater-pressure time series was analyzed to get a better understanding of HM coupled processes during and after the excavation phase as well as the impact of anisotropic geomechanic and hydraulic properties of the clay-rich formation on its hydraulic behavior. Excavation related investigations were completed by means of inclinometer data to characterize the non-elastic and time

  17. Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.

    Science.gov (United States)

    Amato, Anastasia; Lucas, Xavier; Bortoluzzi, Alessio; Wright, David; Ciulli, Alessio

    2018-04-20

    Plant homeodomain (PHD) zinc fingers are histone reader domains that are often associated with human diseases. Despite this, they constitute a poorly targeted class of readers, suggesting low ligandability. Here, we describe a successful fragment-based campaign targeting PHD fingers from the proteins BAZ2A and BAZ2B as model systems. We validated a pool of in silico fragments both biophysically and structurally and solved the first crystal structures of PHD zinc fingers in complex with fragments bound to an anchoring pocket at the histone binding site. The best-validated hits were found to displace a histone H3 tail peptide in competition assays. This work identifies new chemical scaffolds that provide suitable starting points for future ligand optimization using structure-guided approaches. The demonstrated ligandability of the PHD reader domains could pave the way for the development of chemical probes to drug this family of epigenetic readers.

  18. 5-year chemico-physical evolution of concrete-claystone interfaces, Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Mäder, U.; Jenni, A. [Institute of Geological Sciences, University of Berne, Berne (Switzerland); Lerouge, C. [French Geological Survey BRGM, Orléans (France); and others

    2017-04-15

    The Cement-Opalinus Clay Interaction (CI) Experiment at the Mont Terri rock laboratory is a long-term passive diffusion-reaction experiment between contrasting materials of relevance to engineered barrier systems/near-field for deep disposal of radioactive waste in claystone (Opalinus Clay). Reaction zones at interfaces of Opalinus Clay with two different types of concrete (OPC and 'low-pH'/ESDRED) were examined by sampling after 2.2 and 4.9 years. Analytical methods included element mapping (SEM, EPMA), select spot analysis (EDAX), 14C-MMA impregnation for radiography, and powder methods (IR, XRD, clay-exchanger characterisation) on carefully extracted miniature samples (mm). The presence of aggregate grains in concrete made the application of all methods difficult. Common features are a very limited extent of reaction within claystone, and a distinct and regularly zoned reaction zone within the cement matrix that is more extensive in the low-alkali cement (ESDRED). Both interfaces feature a de-calcification zone and overprinted a carbonate alteration zone thought to be mainly responsible for the observed porosity reduction. While OPC shows a distinct sulphate enrichment zone (indicative of ingress from Opalinus Clay), ESDRED displays a wide Mg-enriched zone, also with claystone pore-water as a source. A conclusion is that substitution of OPC by low-alkali cementitious products is not advantageous or necessary solely for the purpose of minimizing the extent of reaction between claystone and cementitious materials. Implications for reactive transport modelling are discussed. (authors)

  19. Implementation of the full-scale emplacement (FE) experiment at the Mont Terri rock laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Müller, H.R.; Garitte, B.; Vogt, T.; and others

    2017-04-15

    Opalinus Clay is currently being assessed as the host rock for a deep geological repository for high-level and low- and intermediate-level radioactive wastes in Switzerland. Within this framework, the 'Full-Scale Emplacement' (FE) experiment was initiated at the Mont Terri rock laboratory close to the small town of St-Ursanne in Switzerland. The FE experiment simulates, as realistically as possible, the construction, waste emplacement, backfilling and early post-closure evolution of a spent fuel/vitrified high-level waste disposal tunnel according to the Swiss repository concept. The main aim of this multiple heater test is the investigation of repository-induced thermo-hydro-mechanical (THM) coupled effects on the host rock at this scale and the validation of existing coupled THM models. For this, several hundred sensors were installed in the rock, the tunnel lining, the bentonite buffer, the heaters and the plug. This paper is structured according to the implementation timeline of the FE experiment. It documents relevant details about the instrumentation, the tunnel construction, the production of the bentonite blocks and the highly compacted 'granulated bentonite mixture' (GBM), the development and construction of the prototype 'backfilling machine' (BFM) and its testing for horizontal GBM emplacement. Finally, the plug construction and the start of all 3 heaters (with a thermal output of 1350 Watt each) in February 2015 are briefly described. In this paper, measurement results representative of the different experimental steps are also presented. Tunnel construction aspects are discussed on the basis of tunnel wall displacements, permeability testing and relative humidity measurements around the tunnel. GBM densities achieved with the BFM in the different off-site mock-up tests and, finally, in the FE tunnel are presented. Finally, in situ thermal conductivity and temperature measurements recorded during the first heating months

  20. Applying Squeezing Technique to Clayrocks: Lessons Learned from Experiments at Mont Terri Rock Laboratory

    International Nuclear Information System (INIS)

    Fernandez, A. M.; Sanchez-Ledesma, D. M.; Tournassat, C.; Melon, A.; Gaucher, E.; Astudillo, E.; Vinsot, A.

    2013-01-01

    Knowledge of the pore water chemistry in clay rock formations plays an important role in determining radionuclide migration in the context of nuclear waste disposal. Among the different in situ and ex-situ techniques for pore water sampling in clay sediments and soils, squeezing technique dates back 115 years. Although different studies have been performed about the reliability and representativeness of squeezed pore waters, more of them were achieved on high porosity, high water content and unconsolidated clay sediments. A very few of them tackled the analysis of squeezed pore water from low-porosity, low water content and highly consolidated clay rocks. In this work, a specially designed and fabricated one-dimensional compression cell two directional fluid flow was used to extract and analyse the pore water composition of Opalinus Clay core samples from Mont Terri (Switzerland). The reproducibility of the technique is good and no ionic ultrafiltration, chemical fractionation or anion exclusion was found in the range of pressures analysed: 70-200 MPa. Pore waters extracted in this range of pressures do not decrease in concentration, which would indicate a dilution of water by mixing of the free pore water and the outer layers of double layer water (Donnan water). A threshold (safety) squeezing pressure of 175 MPa was established for avoiding membrane effects (ion filtering, anion exclusion, etc.) from clay particles induced by increasing pressures. Besides, the pore waters extracted at these pressures are representative of the Opalinus Clay formation from a direct comparison against in situ collected borehole waters. (Author)

  1. Applying Squeezing Technique to Clayrocks: Lessons Learned from Experiments at Mont Terri Rock Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, A. M.; Sanchez-Ledesma, D. M.; Tournassat, C.; Melon, A.; Gaucher, E.; Astudillo, E.; Vinsot, A.

    2013-07-01

    Knowledge of the pore water chemistry in clay rock formations plays an important role in determining radionuclide migration in the context of nuclear waste disposal. Among the different in situ and ex-situ techniques for pore water sampling in clay sediments and soils, squeezing technique dates back 115 years. Although different studies have been performed about the reliability and representativeness of squeezed pore waters, more of them were achieved on high porosity, high water content and unconsolidated clay sediments. A very few of them tackled the analysis of squeezed pore water from low-porosity, low water content and highly consolidated clay rocks. In this work, a specially designed and fabricated one-dimensional compression cell two directional fluid flow was used to extract and analyse the pore water composition of Opalinus Clay core samples from Mont Terri (Switzerland). The reproducibility of the technique is good and no ionic ultrafiltration, chemical fractionation or anion exclusion was found in the range of pressures analysed: 70-200 MPa. Pore waters extracted in this range of pressures do not decrease in concentration, which would indicate a dilution of water by mixing of the free pore water and the outer layers of double layer water (Donnan water). A threshold (safety) squeezing pressure of 175 MPa was established for avoiding membrane effects (ion filtering, anion exclusion, etc.) from clay particles induced by increasing pressures. Besides, the pore waters extracted at these pressures are representative of the Opalinus Clay formation from a direct comparison against in situ collected borehole waters. (Author)

  2. Geomechanical behaviour of Opalinus Clay at multiple scales: results from Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Amann, F.; Wild, K.M.; Loew, S. [Institute of Geology, Engineering Geology, Swiss Federal Institute of Technology, Zurich (Switzerland); Yong, S. [Knight Piesold Ltd, Vancouver (Canada); Thoeny, R. [Grundwasserschutz und Entsorgung, AF-Consult Switzerland AG, Baden (Switzerland); Frank, E. [Sektion Geologie (GEOL), Eidgenössisches Nuklear-Sicherheitsinspektorat (ENSI), Brugg (Switzerland)

    2017-04-15

    The paper represents a summary about our research projects conducted between 2003 and 2015 related to the mechanical behaviour of Opalinus Clay at Mont Terri. The research summarized covers a series of laboratory and field tests that address the brittle failure behaviour of Opalinus Clay, its undrained and effective strength, the dependency of petro-physical and mechanical properties on total suction, hydro-mechanically coupled phenomena and the development of a damage zone around excavations. On the laboratory scale, even simple laboratory tests are difficult to interpret and uncertainties remain regarding the representativeness of the results. We show that suction may develop rapidly after core extraction and substantially modifies the strength, stiffness, and petro-physical properties of Opalinus Clay. Consolidated undrained tests performed on fully saturated specimens revealed a relatively small true cohesion and confirmed the strong hydro-mechanically coupled behaviour of this material. Strong hydro-mechanically coupled processes may explain the stability of cores and tunnel excavations in the short term. Pore-pressure effects may cause effective stress states that favour stability in the short term but may cause longer-term deformations and damage as the pore-pressure dissipates. In-situ observations show that macroscopic fracturing is strongly influenced by bedding planes and faults planes. In tunnel sections where opening or shearing along bedding planes or faults planes is kinematically free, the induced fracture type is strongly dependent on the fault plane frequency and orientation. A transition from extensional macroscopic failure to shearing can be observed with increasing fault plane frequency. In zones around the excavation where bedding plane shearing/shearing along tectonic fault planes is kinematically restrained, primary extensional type fractures develop. In addition, heterogeneities such as single tectonic fault planes or fault zones

  3. PhD supervisor-student relationship

    Directory of Open Access Journals (Sweden)

    FILIPE PRAZERES

    2017-10-01

    Full Text Available The relationship between the PhD supervisor and the PhD student is a complex one. When this relationship is neither effective nor efficient, it may yield negative consequences, such as academic failure (1. The intricacy of the supervisor-student relationship may be in part comparable to the one between the physician and his/her patient [see, for example (2]. Both interactions develop over several years and the players involved in each relationship – PhD supervisor-student on the one side and physician-patient on the other side – may at some point of the journey develop different expectations of one another [see, for example (3, 4] and experience emotional distress (5. In both relationships, the perceived satisfaction with the interaction will contribute to the success or failure of the treatment in one case, and in the other, the writing of a thesis. To improve the mentioned satisfaction, not only there is a need to invest time (6, as does the physician to his/ her patients, but also both the supervisor and the PhD student must be willing to negotiate a research path to follow that would be practical and achievable. The communication between the physician and patient is of paramount importance for the provision of health care (7, and so is the communication between the supervisor and PhD student which encourages the progression of both the research and the doctoral study (8. As to a smooth transition to the postgraduate life, supervisors should start thinking about providing the same kind of positive reinforcement that every student is used to experience in the undergraduate course. The recognition for a job well done will mean a lot for a PhD student, as it does for a patient. One good example is the increase in medication compliance by patients with high blood pressure who receive positive reinforcement from their physicians (9. Supervisors can organize regular meetings for (and with PhD students in order to not only discuss their projects

  4. ATLAS PhD Grants 2015

    CERN Multimedia

    Marcelloni De Oliveira, Claudia

    2015-01-01

    ATLAS PHd Grants - We are excited to announce the creation of a dedicated grant scheme (thanks to a donation from Fabiola Gianotti and Peter Jenni following their award from the Fundamental Physics Prize foundation) to encourage young and high-caliber doctoral students in particle physics research (including computing for physics) and permit them to obtain world class exposure, supervision and training within the ATLAS collaboration. This special PhD Grant is aimed at graduate students preparing a doctoral thesis in particle physics (incl. computing for physics) to spend one year at CERN followed by one year support also at the home Institute.

  5. PhD on Track – designing learning for PhD students

    Directory of Open Access Journals (Sweden)

    Gunhild Austrheim

    2013-12-01

    Full Text Available Three years ago we started the project "Information Management for Knowledge Creation". The project was initiated to create online information literacy modules for PhD students. The result of our endeavours, PhD on Track, will be launched in May 2013. The initial stage of the project was mapping out the information behaviour of PhD students, as well as what services they require from the library through a literature review and a focus group study. The findings of these inquiries formed the knowledge base from which we developed our information literacy modules. Our paper will focus on the interaction between content production and user testing when creating PhD on Track. Methods: User testing has been employed throughout the production stage. We have tested navigation and organisation of the web site, content and usability. The project team have conducted expert testing. Analysis: The results from our user testing have played an important part in decisions concerning content production. Our working hypothesis was that the PhD students would want an encyclopaedic website, a place to quickly find answers. However, the user tests revealed that PhD students understood and expected the website to be learning modules. Conclusions: The PhD students in the tests agreed that a site such as this would be useful, especially to new PhD students. They also liked the design, but had some qualms with the level of information. They preferred shorter text, but with more depth. The students would likewise have preferred more practical examples, more illustrations and more discipline specific information. The current content of PhD on Track reflects the feedback from the user testing. We have retained initial ideas such as one section for reviewing and discovering research literature and one section for publishing PhD research work. In addition, we have included more practical examples to indicate efficient workflows or relevant actions in context. Illustrations

  6. Exploring diffusion and sorption processes at the Mont Terri rock laboratory (Switzerland): lessons learned from 20 years of field research

    Energy Technology Data Exchange (ETDEWEB)

    Leupin, O.X. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); Van Loon, L.R. [Paul Scherrer Institute PSI, Villigen (Switzerland); Gimmi, T. [Institute of Geological Sciences, University of Berne, Berne (Switzerland); Gimmi, T. [Institute of Environmental Assessment and Water Research IDAEA-CSIC, Barcelona (Spain); and others

    2017-04-15

    Transport and retardation parameters of radionuclides, which are needed to perform a safety analysis for a deep geological repository for radioactive waste in a compacted claystone such as Opalinus Clay, must be based on a detailed understanding of the mobility of nuclides at different spatial scales (laboratory, field, geological unit). Thanks to steadily improving experimental designs, similar tracer compositions in different experiments and complementary small laboratory-scale diffusion tests, a unique and large database could be compiled. This paper presents the main findings of 20 years of diffusion and retention experiments at the Mont Terri rock laboratory and their impact on safety analysis. (authors)

  7. In situ corrosion measurements by electrochemical method (IC experiment) at Mont Terri

    International Nuclear Information System (INIS)

    Dewonck, S.; Bataillon, C.; Crusset, D.; Schwyn, B.; Nakayama, N.; Kwong, G.

    2010-01-01

    Document available in extended abstract form only. The study of the interactions of steel pieces with an argillaceous rock is the aim of the IC experiment carried out in the Mont Terri Rock Laboratory (Switzerland). More precisely, the IC experiment consists in monitoring the corrosion rate of various steel (Inconel 690, 316L stainless steel, 2 carbon steels one representative of Andra concept and another of Nagra concept) at 80 deg. C, in anaerobic condition, in contact with the Opalinus clay formation. The corrosion rate monitoring is based on Electrochemical Impedance Spectroscopy (EIS). This method is not disturbing for the corrosion process i.e. the corrosion rate doesn't change during the electrochemical measurement. The main drawback of this method is that the corrosion process must be in stationary or quasi stationary state: EIS can only measure corrosion rates which do not change quickly with time. This method is well adapted for long term corrosion monitoring because long term corrosion rate evolves slowly. A special design of the experimental setup was developed to allow optimal interactions between rock and steel samples. It consists in mounting the steel samples inside of a bore-core section. This section is then placed at the extremity of the borehole equipment. The equipment is inserted in a vertical descending borehole and sealed by a large packer. Another particularity of the experimental setup is the possibility of heating the experimental section up to 80 deg. C. Finally, the equipment was built in such a way that such that it will be retrievable from the borehole after several years of experiment, in order to perform further analyses on the reacting materials (core and steel samples). A circulation loop links the experimental interval to the sampling, measuring various parameters (pH, Eh, electrical conductivity, dissolved oxygen and hydrogen) and control equipment installed in a cabinet, in the gallery of the underground laboratory. At the

  8. The panacea toolbox of a PhD biomedical student.

    Science.gov (United States)

    Skaik, Younis

    2014-01-01

    Doing a PhD (doctor of philosophy) for the sake of contribution to knowledge should give the student an immense enthusiasm through the PhD period. It is the time in one's life that one spends to "hit the nail on the head" in a specific area and topic of interest. A PhD consists mostly of hard work and tenacity; however, luck and genius might also play a little role. You can pass all PhD phases without having both luck and genius. The PhD student should have pre-PhD and PhD toolboxes, which are "sine quibus non" for getting successfully a PhD degree. In this manuscript, the toolboxes of the PhD student are discussed.

  9. Biomedical PhD education - an international perspective

    DEFF Research Database (Denmark)

    Mulvany, Michael J.

    2013-01-01

    The PhD, otherwise known as the doctor of philosophy or Dr. Phil., is an internationally recognized degree, indicating that the PhD graduate has received training in research under supervision. Traditionally, the PhD was the route to an academic career, with most successful PhD graduates receiving...... tenured university positions. However, over the past 20–30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the ‘knowledge society’, and thus...... increase the competitiveness of their countries in the future economies of the world. Thus, only a small fraction of PhD graduates now end up in academic research. Yet, the PhD remains a research degree, and indeed, institutions have become heavily dependent on PhD students for their research output...

  10. PhD competences of food studies

    Directory of Open Access Journals (Sweden)

    Chelo Gonzalez-Martinez

    2014-10-01

    Full Text Available In European Higher Education, learning outcomes and competences have been used sometimes with different meanings and sometimes with the same meaning. But both terms have been more commonly used to refer to knowledge, understanding and abilities a student must demonstrate at the end of a learning experience.  Their use is a consequence of the paradigm shift of the Bologna Process to a learner centered education environment. The definition of standards of competences (or learning outcomes for the PhD degree is thus a need for the quality assurance of this degree. In this work, subject-specific and generic competences for the PhD in Food Science and Technology and their alignment with the European Qualifications Framework (EQF level descriptors for quality assurance purposes have been identified.

  11. ATLAS PhD Grant Scholarship Programme

    CERN Multimedia

    Abha Eli Phoboo

    2014-01-01

    On 11 February, the first recipients of the ATLAS PhD Grant were presented with a certificate by the programme’s selection committee. The three scholars - Lailin Xu of China, Josefina Alconada of Argentina and Gagik Vardanyan of Armenia - were delighted at being able to continue their PhD programmes at CERN.   With certificates, from left: Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, from left: IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James Purvis. (Image: ATLAS/Claudia Marcelloni). Former ATLAS spokespersons Peter Jenni and Fabiola Gianotti started the fund with the Fundamental Physics Prize award money they received last year. Both have used the entirety of their prizes for educational and humanitarian programmes. "We wanted to do something for students who are working on ATLAS, in particular those who otherwise could not come here and actually see the detector they are working on,&am...

  12. PhD students share their work

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    Last week, the second Doctoral Student Assembly gave students in the final stages of their PhD at CERN the chance to meet and present their work.   On 9 May, 24 students who are completing their PhD under the CERN Doctoral Student Programme were joined by their CERN supervisors and some of their university supervisors at an event organised by HR and the Technical Students Committee (TSC). After an address by the Director-General Rolf Heuer and short presentations by Ingrid Haug from HR and TSC Chair Stephan Russenschuck, the students presented their work in a poster session. Held in a packed Council Chamber, the event was a great opportunity for the doctoral students to get to know each other and to share their work in fields as diverse as radiation protection, computing, physics and engineering.

  13. Leonard F. Peltier, MD, PhD, 1920-2003.

    Science.gov (United States)

    Reckling, Frederick W; Lo Vecchio, Janolyn G; Reckling, JoAnn B

    2004-05-01

    Leonard F. Peltier, MD, PhD, was an orthopaedic surgeon, academician, administrator, laboratory investigator, historian, and mentor. His career spanned nearly six decades, beginning with graduate education at the University of Minnesota (UM) under the auspices of Owen H. Wangensteen, MD, PhD. In addition to obtaining a PhD in physiology in the UM Graduate School, he completed general and orthopaedic surgery residencies and attained board certification in each specialty. He served in the US Army Occupation Force Medical Corps in Germany just after World War II. In 1957, at 37 years old, he assumed the chairmanship of the orthopaedic training program at the University of Kansas. In 1971, he couldn't resist the opportunity to become one of the founding members of the "start-up" University of Arizona College of Medicine, accepting an appointment as chair of the new orthopaedic training program, where he remained until his retirement in 1990. He took clinical problems to the laboratory, and made important scientific contributions, particularly in the area of fat embolism and in using calcium sulfate (plaster of Paris) to fill bone defects. He served on governing boards of national professional organizations and presided over the American Association for the Surgery of Trauma from 1980-1981. Throughout his career, he was fascinated by, and published extensively in, the history of medicine arena. Known fondly as "the professor" to many of his residents and colleagues, he had a pragmatic, honest, upbeat, and often humorous approach to life's challenges, valuing personal integrity above other virtues. He explored various eclectic interests far beyond his professional contributions while maintaining his family as a central priority. With his exemplary productivity and interests in the surgical and laboratory sciences, history of medicine, appreciation of fine arts, and perceptive and effective interactions with family, friends, patients, and colleagues, the memory of Leonard

  14. Diffusion and retention experiment at the Mont Terri underground rock laboratory in St. Ursanne

    International Nuclear Information System (INIS)

    Leupin, O.X.; Wersin, P.; Gimmi, Th.; Van Loon, L.; Eikenberg, J.; Baeyens, B.; Soler, J.M.; Dewonck, S.; Wittebroodt, C.; Samper, J.; Yi, S.; Naves, A.

    2010-01-01

    Document available in extended abstract form only. Because of their favourable hydraulic and retention properties that limit the migration of radionuclides, indurated clays are being considered as potential host rocks for radioactive waste disposal. Migration of radionuclides by diffusion and retention is thereby one of the main concerns for safety assessment and therefore carefully investigated at different scales. The transfer from dispersed sorption batch and diffusion data from lab experiments to field scale is however not always straightforward. Thus, combined sorption and diffusion experiments at both lab and field scale are instrumental for a critical verification of the applicability of such sorption and diffusion data. The present migration field experiment 'DR' (Diffusion and Retention experiment) at the Mont Terri Rock Laboratory (Switzerland) is the continuation of a series of successful diffusion experiments. The design is based on these previous diffusion experiments and has been extended to two diffusion chambers in a single borehole drilled perpendicular to the bedding plane. The radionuclides were injected as a pulse in both upper and lower loops where artificial pore water is circulating. The injected tracers were tritium, iodide, bromide, sodium-22, strontium-85, caesium (stable) for the lower diffusion chamber and deuterium caesium-137, barium-133, cobalt-60, europium-152, selenium (stable) and selenium-75 for the lower diffusion chamber. Their decrease in the circulation fluid - as they diffuse into the clay - is continuously monitored by online?-detection and regular sampling. The goals are fourfold (i) obtain diffusion and retention data for moderately to strongly sorbing tracers and to verify the corresponding data obtained on small-scale lab samples, (ii) improve diffusion data for the rock anisotropy, (iii) quantify effects of the borehole-disturbed zone for non-reactive tracers and (iv) improve data for long term diffusion. The

  15. Distributed fiber-optic temperature sensing: recent improvements and Nagra's applications in the Mont Terri URL

    International Nuclear Information System (INIS)

    Vogt, Tobias; Mueller, Herwig R.; Vietor, Tim; Frieg, Bernd

    2012-01-01

    engineered clay-barriers using DTS. In addition, first results and experiences of Nagra's DTS applications in the Mont Terri URL will be presented. Fiber-optic sensors were installed within the Full-Scale Emplacement (FE) Experiment. The FE-experiment is a full-scale heater test also simulating the construction, emplacement and backfilling of a repository tunnel according to the Swiss concept for high level waste. The THM evolution in the host rock (near- and far-field), tunnel lining and the engineered barrier system will be monitored by several hundred conventional sensors. In addition to thermo-resistive conventional temperature sensors fiber-optic cables amend the temperature monitoring. In the host rock 45 m long inclinometer casings are equipped with fiber-optic cables to observe the longitudinal temperature evolution above the tunnel. The temperature distribution at the interface engineered barrier - tunnel lining is planned to be monitored by fiber-optic cables covering the surface of the tunnel lining. The fiber-optics in combination with the conventional temperature sensors will result in detailed insights into non-uniformity of heat transport within the engineered barrier and the host rock caused by spatial and temporal variability of thermal conductivity and therewith saturation and porosity. (authors)

  16. The status of PhD education in economic, social, and administrative sciences between 2005 and 2008.

    Science.gov (United States)

    Farley, Joel F; Wang, Chi-Chuan; Blalock, Susan J

    2010-09-10

    To describe the funding, education, enrollment, and graduation patterns from economic, social, and administrative sciences PhD programs in colleges and schools of pharmacy in the United States. Economic, social, and administrative sciences PhD programs were identified from the American Association of Colleges of Pharmacy (AACP) Web site. A 41-item online survey instrument was sent to the director of graduate studies of each identified program. Only programs offering a PhD degree were included in the study. Of the 26 programs surveyed, 20 (77%) provided useable responses to the survey instrument. Approximately 91% of PhD programs guarantee funding to incoming students with an average commitment of 2.9 years. On average, students were paid a stipend of $18,000 per year for commitments to research and teaching assistantships, each averaging approximately 2 years in length. Programs admitted an average of 3.5 students per year and graduated approximately 85% of entering students. The majority of students are non-US citizens and accept positions in either academic or industrial positions after graduation. Most economic, social, and administrative sciences PhD programs guarantee funding to incoming PhD candidates. Programs offering funding packages significantly below the average may be at a competitive disadvantage. It is unclear whether the number of students graduating from PhD programs is adequate to fulfill academic and industrial needs.

  17. The PhD by Publication

    Directory of Open Access Journals (Sweden)

    Susi Peacock

    2017-07-01

    Full Text Available Aim/Purpose: The purpose of this work is to develop more nuanced understandings of the PhD by publication, particularly raising awareness of the retrospective PhD by publication. The article aims to contribute to contemporary debates about the differing pathways to the attainment of doctoral study completion and the artifacts submitted for that purpose. It also seeks to support prospective graduate students and supervisors who are embarking upon alternative routes to doctoral accreditation. Background: The PhD is considered the pinnacle of academic study – highly cherished, and replete with deeply held beliefs. In response to changes in job markets, developments in the disciplines, and more varied student cohorts, diverse pathways to completion of this award have emerged, such as the PhD by publication (PhDP. A PhDP may either be prospective or retrospective. For the former, publications are planned and created with their contributions to the PhDP in mind. The retrospective PhD is assembled after some, or most, of the publications have been completed. The artifact submitted for examination in this case consists of a series of peer-reviewed academic papers, books, chapters, or equivalents that have been published or accepted for publication, accompanied by an over-arching narrative. The retrospective route is particularly attractive for professionals who are research-active but lack formal academic accreditation at the highest level. Methodology: This article calls upon a literature review pertaining to the award of PhDP combined with the work of authors who offer their personal experiences of the award. The author also refers to her candidature as a Scottish doctoral student whilst studying for the award of PhD by publication. Contribution: This work raises awareness of the PhDP as a credible and comparable pathway for graduate students. The article focuses upon the retrospective PhDP which, as with all routes to doctoral accreditation, has

  18. Emerging technologies for sustainable irrigation – a tribute to the career of Terry Howell, Sr. Selected papers from the 2015 ASABE and IA irrigation symposium

    Science.gov (United States)

    This article is an introduction to the “Emerging Technologies in Sustainable Irrigation – A Tribute to the Career of Terry Howell, Sr.” Special Collection in this issue of Transactions ASABE and the next issue of Applied Engineering in Agriculture, consisting of 15 articles selected from 62 papers a...

  19. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

    DEFF Research Database (Denmark)

    Madsen, Chris D; Pedersen, Jesper Thorhauge; Venning, Freja A

    2015-01-01

    , which can be prevented by simultaneous depletion of HIF-1α. Treatment with the PHD inhibitor DMOG in an orthotopic breast cancer model significantly decreases spontaneous metastases to the lungs and liver, associated with decreased tumour stiffness and fibroblast activation. PHD2 depletion in CAFs co......-injected with tumour cells similarly prevents CAF-induced metastasis to lungs and liver. Our data argue that reversion of CAFs towards a less active state is possible and could have important clinical implications....

  20. Low immediate scientific yield of the PhD among medical doctors

    DEFF Research Database (Denmark)

    Fosbol, Emil L.; Fosbøl, Philip Loldrup; Rerup, Sofie

    2016-01-01

    . Scientific activity over time was assessed independently of author-rank and inactivity was measured relative to the date of graduation. Factors associated with inactivity were identified using multivariable logistic regression. 88.6 % of the PhD theses were conducted in internal medicine vs. 11...

  1. Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016)

    OpenAIRE

    Carretero Pérez, Jesús; García Blas, Javier; Petcu, Dana

    2016-01-01

    Proceedings of the First PhD Symposium on Sustainable Ultrascale Computing Systems (NESUS PhD 2016) Timisoara, Romania. February 8-11, 2016. The PhD Symposium was a very good opportunity for the young researchers to share information and knowledge, to present their current research, and to discuss topics with other students in order to look for synergies and common research topics. The idea was very successful and the assessment made by the PhD Student was very good. It also helped t...

  2. The role of PHD2 mutations in the pathogenesis of erythrocytosis

    Directory of Open Access Journals (Sweden)

    Gardie B

    2014-07-01

    of EPO transcription. The α subunits of the hypoxia-inducible transcription factor are hydroxylated by three prolyl hydroxylase domain (PHD enzymes, which belong to the iron and 2-oxoglutarate-dependent oxygenase superfamily. Sequence analysis of the genes encoding the PHDs in patients with erythrocytosis has revealed heterozygous germline mutations only occurring in Egl nine homolog 1 (EGLN1, also known as PHD2, the gene that encodes PHD2. To date, 24 different EGLN1 mutations comprising missense, frameshift, and nonsense mutations have been described. The phenotypes associated with the patients carrying these mutations are fairly homogeneous and typically limited to erythrocytosis with normal to elevated EPO. However, exceptions exist; for example, there is one case with development of concurrent paraganglioma (PHD2-H374R. Analysis of the erythrocytosis-associated PHD2 missense mutations has shown heterogeneous results. Structural studies reveal that mutations can affect different domains of PHD2. Some are close to the hypoxia-inducible transcription factor α/2-oxoglutarate or the iron binding sites for PHD2. In silico studies demonstrate that the mutations do not always affect fully conserved residues. In vitro and in cellulo studies showed varying effects of the mutations, ranging from mild effects to severe loss of function. The exact mechanism of a potential tumor-suppressor role for PHD2 still needs to be elucidated. A knockin mouse model expressing the first reported PHD2-P317R mutation recapitulates the phenotype observed in humans (erythrocytosis with inappropriately normal serum EPO levels and demonstrates that haploinsufficiency and partial deregulation of PHD2 is sufficient to cause erythrocytosis. Keywords: PHD2, EGLN1, HIF, hypoxia, erythropoietin, erythrocytosis

  3. Young PHD's in Human Space Flight

    Science.gov (United States)

    Wilson, Eleanor

    2002-01-01

    The Cooperating Hampton Roads Organizations for Minorities in Engineering (CHROME) in cooperation with the NASA Office of Space Flight, Human Exploration and Development of Space Enterprise sponsored a summer institute, Young PHD#s (Persons Having Dreams) in Human Space Flight. This 3-day institute used the curriculum of a workshop designed for space professionals, 'Human Space Flight-Analysis and Design: An Integrated, Systematic Approach.' The content was tailored to a high school audience. This institute seeks to stimulate the interest of pre-college students in space flight and motivate them to pursue further experiences in this field. Additionally, this institute will serve as a pilot model for a pre- collegiate training program that can be replicated throughout the country. The institute was complemented with a trip to the Goddard Space Flight Center.

  4. [Stop the compulsive PhD trajectory for junior doctors].

    Science.gov (United States)

    Clevers, J C Hans

    2014-01-01

    It has become the rule rather than the exception that junior doctors in training spend 3-4 years on a research project, culminating in a thesis. Without a PhD, clinical career prospects within and outside academia look rather bleak. Here I argue that PhD degrees should be pursued only by the most talented and motivated young clinicians.

  5. Tracking the PhD Students' Daily Computer Use

    Science.gov (United States)

    Sim, Kwong Nui; van der Meer, Jacques

    2015-01-01

    This study investigated PhD students' computer activities in their daily research practice. Software that tracks computer usage (Manic Time) was installed on the computers of nine PhD students, who were at their early, mid and final stage in doing their doctoral research in four different discipline areas (Commerce, Humanities, Health Sciences and…

  6. Exploring the intricacies of contemporary Phd research process ...

    African Journals Online (AJOL)

    The process leading to a PhD degree award has evolved over a period of many years to become what it is today. There are important considerations and emphasis continually being placed by the degree awarding authorities on the PhD research process leading to this award. The authors of this communication wish to ...

  7. Mechanical properties, mineralogical composition, and micro fabric of Opalinus Clay. Sandy and shaly facies (Mont Terri, Switzerland)

    International Nuclear Information System (INIS)

    Kaufhold, Annette; Graesle, Werner; Plischke, Ingo

    2015-01-01

    For the safe disposal of high-level radioactive waste, different host rocks are currently considered. The favorable properties of claystone are low permeability, retention capacity for some radionuclides, and the ability to self-seal cracks, e.g. by swelling or time-dependent compaction creep. For the understanding of the long-term behavior of clay host rocks, the interaction between mechanical behavior, micro fabric, and mineral composition has to be understood (Bock et al., 2010). In the international research project Mont Terri (Switzerland) the Opalinus Clay (Jurassic Formation) is investigated in an underground rock laboratory (URL). In the present study the relationship between mechanical, mineralogical and micro fabric properties were studied on representative samples of the sandy and shaly facies of the Opalinus Clay (OPA) from Mont Terri. The mineral composition of all samples was analysed by using a complex mineral phase analysis. Therefore, the results of the X-ray diffraction, X-ray fluoreszence, organic and inorganic carbonate analysis (LECO) were adjusted with each other. In the case of the sandy facies (OPA) the mechanical strength inrcreases with increasing carbonate content. Here small carbonate particles form the matrix and act as stabilisator. The carbonates of the shaly facies (OPA), on the other hand, are mainly fossil fragments (e.g. shells) aligned parallel to bedding. These large carbonate particles are acting as predetermined breaking surfaces. Hence, in the case of shaly facies (OPA) the mechanical strength decreases with increasing carbonate content. Image Analyses (Fiji registered ) of scattering electron microscope images of polished sections proved the determined microstructural differences. Besides, carbonate particles in the sandy facies are mostly isometric, in contrast carbonates of the shaly facies show different shapes. This is explained further in terms of the aspect ratio. The mechanical tests were carried out as triaxial

  8. Mechanical properties, mineralogical composition, and micro fabric of Opalinus Clay. Sandy and shaly facies (Mont Terri, Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Kaufhold, Annette; Graesle, Werner [BGR Hannover (Germany); Plischke, Ingo

    2015-07-01

    For the safe disposal of high-level radioactive waste, different host rocks are currently considered. The favorable properties of claystone are low permeability, retention capacity for some radionuclides, and the ability to self-seal cracks, e.g. by swelling or time-dependent compaction creep. For the understanding of the long-term behavior of clay host rocks, the interaction between mechanical behavior, micro fabric, and mineral composition has to be understood (Bock et al., 2010). In the international research project Mont Terri (Switzerland) the Opalinus Clay (Jurassic Formation) is investigated in an underground rock laboratory (URL). In the present study the relationship between mechanical, mineralogical and micro fabric properties were studied on representative samples of the sandy and shaly facies of the Opalinus Clay (OPA) from Mont Terri. The mineral composition of all samples was analysed by using a complex mineral phase analysis. Therefore, the results of the X-ray diffraction, X-ray fluoreszence, organic and inorganic carbonate analysis (LECO) were adjusted with each other. In the case of the sandy facies (OPA) the mechanical strength inrcreases with increasing carbonate content. Here small carbonate particles form the matrix and act as stabilisator. The carbonates of the shaly facies (OPA), on the other hand, are mainly fossil fragments (e.g. shells) aligned parallel to bedding. These large carbonate particles are acting as predetermined breaking surfaces. Hence, in the case of shaly facies (OPA) the mechanical strength decreases with increasing carbonate content. Image Analyses (Fiji {sup registered}) of scattering electron microscope images of polished sections proved the determined microstructural differences. Besides, carbonate particles in the sandy facies are mostly isometric, in contrast carbonates of the shaly facies show different shapes. This is explained further in terms of the aspect ratio. The mechanical tests were carried out as triaxial

  9. Launching a Geoscience Career: Insights Gained from MS PHD'S Beyond the PhD

    Science.gov (United States)

    Guzman, W. I.; Johnson, A.; Williamson Whitney, V.; Jansma, P. E.; Huggans, M. J.; Ricciardi, L.

    2013-05-01

    The Beyond the PhD (B-PhD) Professional Development Program is the newest addition to the Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S®) Professional Development Program in Earth System Science. This exciting new program is designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. Building upon MS PHD'S extensive professional development activities provided to URM undergraduate and graduate students, B-PhD's vision is to encourage and support URM doctoral students and early career PhD's in becoming part of the global workforce. (Since its inception in 2003, MSPHD'S supports 213 participants of which 42 have achieved the doctoral degree and another 71 are enrolled in doctoral programs.) By providing customized support and advocacy for participants, B-PhD facilitates smoother and informed transitions from graduate school to postdoctoral and tenure-track positions, as well as other "first" jobs in academia, government, industry, and non-profit organizations. In 2011, the first conference for 18 doctoral candidate and recent graduates was hosted at the University of Texas at Arlington's (UTA) College of Science. Using a format of guest speakers, brown bag discussions, and interactive breakout sessions, participants engaged in sessions entitled "Toolkits for Success in Academia, Business and Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This presentation will discuss outcomes from this pilot project, the use of social media to track and support ongoing B-PhD activities, and objectives for future B-PhD workshops.

  10. Improving completion rates of students in biomedical PhD programs: an interventional study.

    Science.gov (United States)

    Viđak, Marin; Tokalić, Ružica; Marušić, Matko; Puljak, Livia; Sapunar, Damir

    2017-08-25

    Analysis of graduation success at the University of Split School of Medicine PhD programs conducted in 2011 revealed that only 11% of students who enrolled and completed their graduate coursework between 1999 and 2011 earned a doctoral degree. In this prospective cohort study we evaluated and compared three PhD programs within the same medical school, where the newest program, called Translational Research in Biomedicine (TRIBE), established in the academic year 2010/11, aimed to increase the graduation rate through an innovative approach. The intervention in the new program was related to three domains: redefined recruitment strategy, strict study regulations, and changes to the curriculum. We compared performance of PhD students between the new and existing programs and analyzed their current status, time to obtain a degree (from enrolment to doctorate), age at doctorate, number of publications on which the thesis was based and the impact factor of journals in which these were published. These improvement strategies were associated with higher thesis completion rate and reduced time to degree for students enrolled in the TRIBE program. There was no change in the impact factor or number of publications that were the basis for the doctoral theses. Our study describes good practices which proved useful in the design or reform of the PhD training program.

  11. Water Retention Capacity of Argillite from the VE Test - Phase II at Mont Terri: Effect of Ventilation

    Energy Technology Data Exchange (ETDEWEB)

    Villar, M. V.; Fernandez, A. M.; Melon, A. M.

    2009-10-12

    The VE (ventilation) test carried out at the Mont Terri underground laboratory in Switzerland intended to evaluate in situ the behaviour of a consolidated clay formation when subjected to alternate periods of flow of wet and dry air during several months. For that, a 10-m gallery was excavated in the Opalinus Clay formation and carefully instrumented. Before and after a second ventilation phase boreholes were drilled. Samples were taken from the drill cores and were analysed from mineralogical and geochemical points of view. Also, the retention curves of these samples were determined in the laboratory following drying paths performed under free volume conditions at 20 degree centigrade, what is the content of this report. Although there are not large differences in the WRC of samples taken from different boreholes, at different distances from the gallery wall or before or after ventilation, those samples taken near the gallery wall and after ventilation tend to show a higher water retention capacity. This has been correlated to the higher salinity of the pore water of these samples, what increases their osmotic suction. This effect is attenuated towards high suctions. (Author) 10 refs.

  12. Water Retention Capacity of Argillite from the VE Test - Phase II at Mont Terri: Effect of Ventilation

    International Nuclear Information System (INIS)

    Villar, M. V.; Fernandez, A. M.; Melon, A. M.

    2009-01-01

    The VE (ventilation) test carried out at the Mont Terri underground laboratory in Switzerland intended to evaluate in situ the behaviour of a consolidated clay formation when subjected to alternate periods of flow of wet and dry air during several months. For that, a 10-m gallery was excavated in the Opalinus Clay formation and carefully instrumented. Before and after a second ventilation phase boreholes were drilled. Samples were taken from the drill cores and were analysed from mineralogical and geochemical points of view. Also, the retention curves of these samples were determined in the laboratory following drying paths performed under free volume conditions at 20 degree centigrade, what is the content of this report. Although there are not large differences in the WRC of samples taken from different boreholes, at different distances from the gallery wall or before or after ventilation, those samples taken near the gallery wall and after ventilation tend to show a higher water retention capacity. This has been correlated to the higher salinity of the pore water of these samples, what increases their osmotic suction. This effect is attenuated towards high suctions. (Author) 10 refs

  13. Seven steps towards a PhD in psychiatry.

    Science.gov (United States)

    Molina-Ruiz, Rosa María

    2016-12-01

    The present review aims to describe the main steps for completing a psychiatric PhD thesis with success. A selective review of the literature and the author's experience as a psychiatrist completing a PhD. Deciding upon a topic, choosing a mentor, organising your time, persevering and remaining motivated are the key elements. Preparedness and diligence lead the way towards a PhD. This advice is also relevant for those undertaking research at any stage of their career. © The Royal Australian and New Zealand College of Psychiatrists 2016.

  14. Meet EPA Natural Resource Economist Marisa Mazzotta, Ph.D.

    Science.gov (United States)

    Marisa Mazzotta, Ph.D. currently works as an Economist at EPA's Atlantic Ecology Division. Her research focuses on the public's valuation and prioritization of natural resources, and the relationship between ecological changes and economic benefits.

  15. Meet EPA Scientist Jordan West, Ph.D.

    Science.gov (United States)

    Jordan West, Ph.D. is an aquatic ecologist at EPA. Her areas of expertise include freshwater & marine ecology, climate change impacts and adaptation, resilience and threshold theory, environmental risk assessment, expert elicitation & stakeholder processes

  16. Meet EPA Scientist Susan Yee, Ph.D.

    Science.gov (United States)

    Susan Yee, Ph.D., is an ecologist at EPA's Gulf Ecology Division. She is working on the Puerto Rico Sustainable Communities program, developing decision support tools to evaluate how alternative decisions impact coastal ecosystem goods and services

  17. Meet EPA Engineer Shawn Ryan, Ph.D.

    Science.gov (United States)

    Shawn Ryan, Ph.D. is a chemical engineer at EPA's National Homeland Security Research Center. He has worked at EPA for 12 years, nine of which have been devoted to leading research to support decontamination and consequence management.

  18. Meet EPA Chemist Quincy Teng, Ph.D.

    Science.gov (United States)

    EPA research chemist Quincy Teng, Ph.D., focuses on the application of metabolomics—a relatively new, specialized field of biochemistry focused on studying small molecules known as metabolites—on environmental and life sciences.

  19. Meet EPA Scientist Jody Shoemaker, Ph.D.

    Science.gov (United States)

    EPA research chemist Jody Shoemaker, Ph.D., works to support Agency efforts to protect drinking water. She helps develop methods for analyzing organic chemicals on the Drinking Water Contaminant Candidate List (CCL).

  20. Meet EPA Environmental Engineer Terra Haxton, Ph.D.

    Science.gov (United States)

    EPA Environmental Engineer Terra Haxton, Ph.D., uses computer simulation models to protect drinking water. She investigates approaches to help water utilities be better prepared to respond to contamination incidents in their distribution systems.

  1. Meet EPA Scientist Jeff Szabo, Ph.D.

    Science.gov (United States)

    EPA scientist Jeff Szabo, Ph.D., has worked for the EPA’s National Homeland Security Research Center since 2005. He conducts and manages water security research projects at EPA’s Test and Evaluation facility.

  2. Meet EPA Scientist Tim Shafer, Ph.D.

    Science.gov (United States)

    Tim Shafer earned his bachelor’s degree in biology and chemistry from Hope College in Holland, MI, in 1986 and his Ph.D. in pharmacology and environmental toxicology from Michigan State University in 1991.

  3. Meet EPA Ecologist Paul Mayer, Ph.D.

    Science.gov (United States)

    EPA ecologist Paul Mayer, Ph.D. works in EPA's Groundwater and Ecosystem Restoration division where he studies riparian zones (the area along rivers and streams where the habitats are influenced by both the land and water) and stream restoration

  4. ebibliographical compilation of phd theses produced at the faculty

    African Journals Online (AJOL)

    USER

    2015-06-01

    Jun 1, 2015 ... comprehensive list of Ph.D theses produced by the following ... Science: Applied and Plant Biology, Micro-Biology, ... Communities. ... Water Purification Potentials and in-vivo ... Cultivation at Small-Hoiders Level in Semi.

  5. Experiments on thermo-hydro-mechanical behaviour of Opalinus Clay at Mont Terri rock laboratory, Switzerland

    Directory of Open Access Journals (Sweden)

    Paul Bossart

    2017-06-01

    Full Text Available Repositories for deep geological disposal of radioactive waste rely on multi-barrier systems to isolate waste from the biosphere. A multi-barrier system typically comprises the natural geological barrier provided by the repository host rock – in our case the Opalinus Clay – and an engineered barrier system (EBS. The Swiss repository concept for spent fuel and vitrified high-level waste (HLW consists of waste canisters, which are emplaced horizontally in the middle of an emplacement gallery and are separated from the gallery wall by granular backfill material (GBM. We describe here a selection of five in-situ experiments where characteristic hydro-mechanical (HM and thermo-hydro-mechanical (THM processes have been observed. The first example is a coupled HM and mine-by test where the evolution of the excavation damaged zone (EDZ was monitored around a gallery in the Opalinus Clay (ED-B experiment. Measurements of pore-water pressures and convergences due to stress redistribution during excavation highlighted the HM behaviour. The same measurements were subsequently carried out in a heater test (HE-D where we were able to characterise the Opalinus Clay in terms of its THM behaviour. These yielded detailed data to better understand the THM behaviours of the granular backfill and the natural host rock. For a presentation of the Swiss concept for HLW storage, we designed three demonstration experiments that were subsequently implemented in the Mont Terri rock laboratory: (1 the engineered barrier (EB experiment, (2 the in-situ heater test on key-THM processes and parameters (HE-E experiment, and (3 the full-scale emplacement (FE experiment. The first demonstration experiment has been dismantled, but the last two ones are on-going.

  6. Corrosion of carbon steel in clay environments relevant to radioactive waste geological disposals, Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Necib, S. [Agence Nationale pour la Gestion des Déchets Radioactifs ANDRA, Meuse Haute-Marne, Center RD 960, Bure (France); Diomidis, N. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); Keech, P. [Nuclear Waste Management Organisation NWMO, Toronto (Canada); Nakayama, M. [Japan Atomic Energy Agency JAEA, Horonobe-Cho (Japan)

    2017-04-15

    Carbon steel is widely considered as a candidate material for the construction of spent fuel and high-level waste disposal canisters. In order to investigate corrosion processes representative of the long term evolution of deep geological repositories, two in situ experiments are being conducted in the Mont Terri rock laboratory. The iron corrosion (IC) experiment, aims to measure the evolution of the instantaneous corrosion rate of carbon steel in contact with Opalinus Clay as a function of time, by using electrochemical impedance spectroscopy measurements. The Iron Corrosion in Bentonite (IC-A) experiment intends to determine the evolution of the average corrosion rate of carbon steel in contact with bentonite of different densities, by using gravimetric and surface analysis measurements, post exposure. Both experiments investigate the effect of microbial activity on corrosion. In the IC experiment, carbon steel showed a gradual decrease of the corrosion rate over a period of 7 years, which is consistent with the ongoing formation of protective corrosion products. Corrosion product layers composed of magnetite, mackinawite, hydroxychloride and siderite with some traces of oxidising species such as goethite were identified on the steel surface. Microbial investigations revealed thermophilic bacteria (sulphate and thiosulphate reducing bacteria) at the metal surface in low concentrations. In the IC-A experiment, carbon steel samples in direct contact with bentonite exhibited corrosion rates in the range of 2 µm/year after 20 months of exposure, in agreement with measurements in absence of microbes. Microstructural and chemical characterisation of the samples identified a complex corrosion product consisting mainly of magnetite. Microbial investigations confirmed the limited viability of microbes in highly compacted bentonite. (authors)

  7. In-situ experiments on bentonite-based buffer and sealing materials at the Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Wieczorek, K. [Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) GmbH, Braunschweig (Germany); Gaus, I. [National Cooperative for the Disposal of Radioactive Waste (NAGRA), Wettingen (Switzerland); Mayor, J. C. [Empresa Nacional de Residuos Radiactivos SA (ENRESA), Madrid (Spain); and others

    2017-04-15

    Repository concepts in clay or crystalline rock involve bentonite-based buffer or seal systems to provide containment of the waste and limit advective flow. A thorough understanding of buffer and seal evolution is required to make sure the safety functions are fulfilled in the short and long term. Experiments at the real or near-real scale taking into account the interaction with the host rock help to make sure the safety-relevant processes are identified and understood and to show that laboratory-scale findings can be extrapolated to repository scale. Three large-scale experiments on buffer and seal properties performed in recent years at the Mont Terri rock laboratory are presented in this paper: The 1:2 scale HE-E heater experiment which is currently in operation, and the full-scale engineered barrier experiment and the Borehole Seal experiment which have been completed successfully in 2014 and 2012, respectively. All experiments faced considerable difficulties during installation, operation, evaluation or dismantling that required significant effort to overcome. The in situ experiments show that buffer and seal elements can be constructed meeting the expectations raised through small-scale testing. It was, however, also shown that interaction with the host rock caused additional effects in the buffer or seal that could not always be quantified or even anticipated from the experience of small-scale tests (such as re-saturation by pore-water from the rock, interaction with the excavation damaged zone in terms of preferential flow or mechanical effects). This led to the conclusion that testing of the integral system buffer/rock or seal/rock is needed. (authors)

  8. The PhD Conundrum in South African Academia

    Science.gov (United States)

    Breier, Mignonne; Herman, Chaya

    2017-01-01

    South African universities need more academics with PhDs, from historically disadvantaged population groups in particular, but they face a conundrum. In order to have more staff with PhDs, they need to produce more PhD graduates. But in order to produce more PhD graduates, they need more staff with PhDs to supervise. This article explores this…

  9. Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD.

    Science.gov (United States)

    Topper, James N; Rutherford, John D

    2016-11-15

    Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine. He completed postgraduate training in internal medicine and cardiovascular disease at the Brigham and Women's Hospital in Boston and is board certified in both disciplines. © 2016 American Heart Association, Inc.

  10. Interview with Xiaoli Wang PhD winner of CACA 2016 Young Investigator Award

    Directory of Open Access Journals (Sweden)

    Xiaoli Wang

    2016-07-01

    Full Text Available Xiaoli Wang is currently an R&D Senior Scientist in Agilent’s HPLC instrument R&D group at Agilent Technologies, Waldbronn, Germany. Prior to this, he was an R&D manager in Agilent’s CrossLab Group in the US focusing on development of novel chromatographic columns. He has a B.S. degree in Chemistry from Peking University, Beijing China and a PhD. degree in Analytical Chemistry from the University of Minnesota in 2006. He started his industrial career in the pharmaceutical industry at AstraZeneca for four years before joining Agilent Technologies in 2010. Recently, he won the prestigious 2016 Young Investigator Award from Chinese American Chromatography Association (CACA. This interview was conducted by Roland J.W. Meesters PhD, Editor-in-Chief of Journal of Applied Bioanalysis.

  11. Emerging areas of nursing science and PhD education for the 21(st) century: response to commentaries.

    Science.gov (United States)

    Henly, Susan J; McCarthy, Donna O; Wyman, Jean F; Alt-White, Anna C; Stone, Patricia W; McCarthy, Ann Marie; Redeker, Nancy S; Dunbar-Jacob, Jacqueline; Titler, Marita G; Conley, Yvette P; Heitkemper, Margaret M; Moore, Shirley M

    2015-01-01

    We respond to commentaries from the American Academy of Nursing, the American Association of Colleges of Nursing, and the National Institute of Nursing Research on our thoughts about integrating emerging areas of science into nursing PhD programs. We identify areas of agreement and focus our response on cross-cutting issues arising from cautions about the unique focus of nursing science and how best to proceed with incorporation of emerging areas of science into nursing PhD programs. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. EZG08 project: acoustic experiments to monitor the EDZ during the gallery excavation process in the Mont Terri Underground Research Laboratory (Switzerland)

    International Nuclear Information System (INIS)

    Le Gonidec, Y.; Kergosien, B.; Schubnel, A.; Gueguen, Y.; Wassermann, J.; Gibert, D.; Sarout, J.; Nussbaum, C.

    2010-01-01

    Document available in extended abstract form only. In the Underground Research Laboratory (URL) at Mont Terri, a new gallery G08 was planned to be excavated in 2008 following an original process: the excavation process allowed to monitor the Excavation Damaged Zone (EDZ) from geophysical measurements designed and installed at the end of face of the EZ-G04 gallery during the excavation from the other side, i.e. the end face of the EZ-G08 gallery. The objectives of the project concern spatio-temporal changes of the EDZ: among the methodological developments adapted for the EZG08 project to provide complementary information, acoustic experiments have been prepared in horizontal boreholes to perform the continuous acoustic monitoring of the Excavation Damaged Zone (EDZ). The acoustic measurements, performed on acoustic arrays of several receivers, have been recorded during one month, following two main steps: - Active acoustic surveys: a source is introduced in a central borehole (BEZG5) allowing tomography experiments in the far field and in the near field, i.e. close to and far from BEZG5, respectively. - Acoustic emissions: during the excavation process, numerous acoustic emissions can be detected and associated to micro-seismic events due to rapid crack propagation, generated by the rock relaxation, or simply associated to the excavation process. From the tomography measurements, the acoustic wave velocity field can be estimated, with P and S-wave velocities roughly equal to 2500 m/s-3500 m/s, and 1500 m/s, respectively. The acoustic setup does not show variations of P-wave velocity during the campaign, but spatial variations which could be associated to anisotropic elastic properties of the rock with the maximum P-wave velocities close to the bedding plane. An original method based on a multifrequency approach puts in evidence a frequency dependence of the velocity, with a striking phenomena since the wave velocity decreases with increasing frequency. This effect

  13. PhD students: making research and publishing

    Directory of Open Access Journals (Sweden)

    Ioan Sporea, MD, PhD

    2016-12-01

    Full Text Available PhD student time is very interesting in the life of researchers. Many of them are young graduates, without or with very few experience in the field of scientific research. During four years, they must become experts in a narrow field (virtually, the subject of their PhD thesis, but at the same time they have to be trained for research and for publishing. Is it possible? It is mandatory! PhD students start with a one year training in the basic field of research during which they attend different courses regarding how to search the literature, how to perform research, how to perform statistical analysis, how to prepare a paper, where and how to publish and so on. Following this training year, together with their mentor (the coordinator of the PhD thesis, the PhD student starts working on the thesis. And this means reading as much as possible significant published data regarding his/her subject, proper research (basic, experimental, or clinical, and finally preparing papers for publication (in the beginning as abstracts for different meetings and later as original articles in dedicated journals.Participation of PhD students to different meetings is important to improve the quality of their research as an exercise for oral presentations. On the other hand, oral presentation is useful because the paper is open for discussion and corrections can be made during and after the oral presentation. During last ten years, there were organized conferences for PhD students and young doctors, particularly in Târgu Mureș and Timișoara. It was a good opportunity to show results, to discuss and to cooperate.This is why in December 2016, the Doctoral School of Victor Babes University of Medicine and Pharmacy decided to organize a scientific competition between PhD students, in an interesting scientific session. The top 10 PhD students (according to the cumulative Impact Factor of their first author publications were invited to present their scientific research

  14. The Production Rate and Employment of Ph.D. Astronomers

    Science.gov (United States)

    Metcalfe, Travis S.

    2008-02-01

    In an effort to encourage self-regulation of the astronomy job market, I examine the supply of, and demand for, astronomers over time. On the supply side, I document the production rate of Ph.D. astronomers from 1970 to 2006 using the UMI Dissertation Abstracts database, along with data from other independent sources. I compare the long-term trends in Ph.D. production with federal astronomy research funding over the same time period, and I demonstrate that additional funding is correlated with higher subsequent Ph.D. production. On the demand side, I monitor the changing patterns of employment using statistics about the number and types of jobs advertised in the AAS Job Register from 1984 to 2006. Finally, I assess the sustainability of the job market by normalizing this demand by the annual Ph.D. production. The most recent data suggest that there are now annual advertisements for about one postdoctoral job, half a faculty job, and half a research/support position for every new domestic Ph.D. recipient in astronomy and astrophysics. The average new astronomer might expect to hold up to 3 jobs before finding a steady position.

  15. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Lindsey A. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States); Allis, C. David [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: alliscd@rockefeller.edu; Wang, Gang G. [Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, Box 78, New York, NY 10065 (United States)], E-mail: gwang@rockefeller.edu

    2008-12-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved 'reader/effector' modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized 'reader' modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., 'writers' and 'erasers') are already known to be involved in various human diseases, mutations in the modification-specific 'reader' proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies

  16. PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

    International Nuclear Information System (INIS)

    Baker, Lindsey A.; Allis, C. David; Wang, Gang G.

    2008-01-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved 'reader/effector' modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialized 'reader' modules that, in some instances, recognize the methylation status of histone lysine residues, such as histone H3 lysine 4 (H3K4). While mutations in catalytic enzymes that mediate the addition or removal of histone modifications (i.e., 'writers' and 'erasers') are already known to be involved in various human diseases, mutations in the modification-specific 'reader' proteins are only beginning to be recognized as contributing to human diseases. For instance, point mutations, deletions or chromosomal translocations that target PHD fingers encoded by many genes (such as recombination activating gene 2 (RAG2), Inhibitor of Growth (ING), nuclear receptor-binding SET domain-containing 1 (NSD1) and Alpha Thalassaemia and Mental Retardation Syndrome, X-linked (ATRX)) have been associated with a wide range of human pathologies including immunological disorders, cancers, and neurological diseases. In this review, we will discuss the structural features of PHD fingers as well as the diseases for which direct mutation or dysregulation of the PHD finger has been reported. We propose that misinterpretation of the epigenetic marks may serve as a general mechanism for human diseases of this category. Determining the regulatory roles of histone covalent modifications in the context of human disease will allow for a more thorough understanding of normal and pathological development, and may provide innovative therapeutic strategies wherein 'chromatin readers' stand as potential drug

  17. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2003-12-01

    Full Text Available Report of PhD Dissertations.Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2003   Marco Meschini, Innocenzo III e il "negotium pacis et fidei" in Linguadoca tra il 1198 e il 1215, Tesi di dottorato di ricerca in Storia medievale, Università Cattolica del Sacro Cuore, 2003   Fabrizio Ricciardelli The Politics of Exclusion in Florence (1215-1434, thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in History, University of Warwick, Department of History, April 2003 Renata Salvarani Baptizare pueros et decimas dare. Cura delle anime, strutturazione ecclesiastica e organizzazione delle campagne in area gardesana fra VIII e XIII secolo (diocesi di Brescia, Verona, Mantova e Trento, Tesi di dottorato in Storia medievale (XV ciclo, Università Cattolica del Sacro Cuore di Milano, 2002-2003   Vito Sibilio Le parole della prima crociata, Tesi di dottorato di ricerca in Storia dei centri delle vie e della cultura dei pellegrinaggi nel medioevo euromediterraneo, Università degli studi di Lecce, 2003Segnalazione di tesi di dottorato. Guido Antonioli Conservator pacis et iustitie. La signoria di Taddeo Pepoli a Bologna (1337-1347, Tesi di dottorato di ricerca in Filologia romanza e cultura medievale (XIII ciclo, Università degli Studi di Bologna, 2001   Elisabetta Filippini «In vassallatico episcopi permanere debent». Rapporti vassallatici e concessioni beneficiali dei vescovi di Cremona fra X e XIII secolo, Tesi di dottorato di Ricerca in Storia Medievale (XV

  18. Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs.

    Directory of Open Access Journals (Sweden)

    Kevin J Paik

    Full Text Available The transcription factor hypoxia-inducible factor 1-alpha (HIF-1α is responsible for the downstream expression of over 60 genes that regulate cell survival and metabolism in hypoxic conditions as well as those that enhance angiogenesis to alleviate hypoxia. However, under normoxic conditions, HIF-1α is hydroxylated by prolyl hydroxylase 2, and subsequently degraded, with a biological half-life of less than five minutes. Here we investigated the therapeutic potential of inhibiting HIF-1α degradation through short hairpin RNA silencing of PHD-2 in the setting of diabetic wounds and limb ischemia. Treatment of diabetic mouse fibroblasts with shPHD-2 in vitro resulted in decreased levels of PHD-2 transcript demonstrated by qRT-PCR, higher levels of HIF-1α as measured by western blot, and higher expression of the downstream angiogenic genes SDF-1 and VEGFα, as measured by qRT-PCR. In vivo, shPHD-2 accelerated healing of full thickness excisional wounds in diabetic mice compared to shScr control, (14.33 ± 0.45 days vs. 19 ± 0.33 days and was associated with an increased vascular density. Delivery of shPHD-2 also resulted in improved perfusion of ischemic hind limbs compared to shScr, prevention of distal digit tip necrosis, and increased survival of muscle tissue. Knockdown of PHD-2 through shRNA treatment has the potential to stimulate angiogenesis through overexpression of HIF-1α and upregulation of pro-angiogenic genes downstream of HIF-1α, and may represent a viable, non-viral approach to gene therapy for ischemia related applications.

  19. Mont Terri Project - Ventilation experiment in Opalinus Clay for the disposal of radioactive waste in underground repositories

    Energy Technology Data Exchange (ETDEWEB)

    Mayor, J. C. [Empresa Nacional de Residuos Radioactivos SA (ENRESA), Madrid (Spain); Garcia-Sineriz, J. [Asociacion para la Investigacion y Desarollo Industrial de los Recursos Naturales (AITEMIN), Madrid (Spain); Velasco, M. [DM Iberia SA, Madrid (Spain); Gomez-Hernandez, J. [Ingenieria Hidraulica y Medio Ambiente, Escuela de Ingenieros de Caminos (UPV), Valencia (Spain); Lloret, A.; Matray, J.-M. [IRSN/DEI/SARG/LETS, Fontenay-aux-Roses (France); Coste, F. [Aradis ESG, Sevres Cedex (France); Giraud, A. [LAEGO-ENSG, Vandoeuvre les Nancy (France); Rothfuchs, T. [Gesellschaft fuer Anlagen und Reaktorsicherheit mbH (GRS), Braunschweig (Germany); Marschall, P. [National Cooperative for the Disposal of Radioactive Waste (Nagra), Wettingen (Switzerland); Roesli, U. [Solexperts AG, Moenchaltorf (Switzerland); Mayer, G. [Colenco Power Engineering Ltd, Baden (Switzerland)

    2007-07-01

    The ventilation of the underground drifts during the construction and operation of a radioactive waste repository could produce the partial desaturation of the rock around the drifts, modifying its thermo-hydro-mechanical properties, especially in clayey rocks. This change of rock properties may have an impact on the design of the repositories (drifts spacing and repository size), which depends on the thermal load that the clay barrier and the rock can accept. To evaluate 'in situ' and better understand the desaturation process of a hard clay formation, the Ventilation Experiment (VE) has been carried out at the Mont Terri underground laboratory (Switzerland), generating a flow of dry air during several months along a section of a microtunnel. Specifically, the VE test has been performed, under practically isothermal conditions (T {approx_equal} 15-16 {sup o}C), in a 10 m long section of a non-lined horizontal microtunnel (diameter = 1.3 m), excavated in 1999 in the shaly facies of the Opalinus Clay of Mont Terri. The microtunnel is oriented perpendicular to the bedding strike direction of the rock (mean value of the bedding dip {approx_equal} 25{sup o}). The VE experiment real data and its modelling have shown that the desaturation of clayey rocks of low hydraulic conductivity (K < 10{sup -12} m/s) due to ventilation is very small. Under real repository conditions, the thermal and hydro-mechanical rock characteristics will not be practically affected by the ventilation. Specifically, the monitoring of the VE test (mainly the hygrometer data, confirmed also by the geoelectrical measurements) indicates that, after about 5 months of ventilation with almost dry air, the rock relative humidity (and then the degree of saturation) was less than 95% only in a ring of thickness less than 40 cm. Nevertheless, a suction state (subatmospheric liquid pressures) developed up to a distance of about 2 m, but it should be kept in mind that a clayey rock such as the

  20. Mont Terri Project - Ventilation experiment in Opalinus Clay for the disposal of radioactive waste in underground repositories

    International Nuclear Information System (INIS)

    Mayor, J. C.; Garcia-Sineriz, J.; Velasco, M.; Gomez-Hernandez, J.; Lloret, A.; Matray, J.-M.; Coste, F.; Giraud, A.; Rothfuchs, T.; Marschall, P.; Roesli, U.; Mayer, G.

    2007-01-01

    The ventilation of the underground drifts during the construction and operation of a radioactive waste repository could produce the partial desaturation of the rock around the drifts, modifying its thermo-hydro-mechanical properties, especially in clayey rocks. This change of rock properties may have an impact on the design of the repositories (drifts spacing and repository size), which depends on the thermal load that the clay barrier and the rock can accept. To evaluate 'in situ' and better understand the desaturation process of a hard clay formation, the Ventilation Experiment (VE) has been carried out at the Mont Terri underground laboratory (Switzerland), generating a flow of dry air during several months along a section of a microtunnel. Specifically, the VE test has been performed, under practically isothermal conditions (T ≅ 15-16 o C), in a 10 m long section of a non-lined horizontal microtunnel (diameter = 1.3 m), excavated in 1999 in the shaly facies of the Opalinus Clay of Mont Terri. The microtunnel is oriented perpendicular to the bedding strike direction of the rock (mean value of the bedding dip ≅ 25 o ). The VE experiment real data and its modelling have shown that the desaturation of clayey rocks of low hydraulic conductivity (K -12 m/s) due to ventilation is very small. Under real repository conditions, the thermal and hydro-mechanical rock characteristics will not be practically affected by the ventilation. Specifically, the monitoring of the VE test (mainly the hygrometer data, confirmed also by the geoelectrical measurements) indicates that, after about 5 months of ventilation with almost dry air, the rock relative humidity (and then the degree of saturation) was less than 95% only in a ring of thickness less than 40 cm. Nevertheless, a suction state (subatmospheric liquid pressures) developed up to a distance of about 2 m, but it should be kept in mind that a clayey rock such as the Opalinus Clay is quasi-saturated for suction values up

  1. Predictive hydro-mechanical excavation simulation of a mine-by test at the Mont Terri rock laboratory

    International Nuclear Information System (INIS)

    Krug, St.; Shao, H.; Hesser, J.; Nowak, T.; Kunz, H.; Vietor, T.

    2010-01-01

    Document available in extended abstract form only. The Mont Terri rock laboratory was extended from mid October 2007 to end 2008 with the goal to allow the project partners to continue their cooperative research on the long term. The extension of the underground laboratory by the excavation of an additional 165 metres long access tunnel (Gallery 08) with four niches was taken as opportunity to conduct an instrumented mine-by test in one of the niches (Niche 2/Niche MB). The measurements during the bedding parallel excavation provided a large amount of data as a basis to understand the hydro-mechanical (HM) coupled behaviour of Opalinus Clay around the excavated niche. BGR was involved in the in-situ investigations (seismic measurements) as a member of the experiment team consisting of five organisations (incl. NAGRA, ANDRA, GRS, Obayashi). An important issue for BGR is the application of the numerical code RockFlow (RF) for HM coupled simulations in order to understand the behaviour of Opalinus Clay by the use of the gained measuring data for validation. Under the management of NAGRA a blind prediction was carried out for a group of modelers belonging to some of the experiment team organisations. After a first comparison between the numerical results of different HM coupled models during the prediction meeting of the teams in June 2009 the measurement data are provided by NAGRA in order to validate the numerical models. Basically the model predictions have already shown the correct tendencies and ranges of observed deformation and pore water pressure evolution besides some under- or overestimations. The future RF validation results after having done some slight parameter adjustments are intended to be presented in the paper. The excavation of Niche 2 was done from 13 October to 7 November 2008 with a constant excavation rate of 1.30 m per day. The orientation of the niche follows the bedding strike, which amounts 60 deg.. The bedding planes have an average dip of

  2. The Training and Work of Ph.D. Physical Scientists

    Science.gov (United States)

    Smith, S. J.; Schweitzer, A. E.

    2003-05-01

    Doctoral education has often been viewed as the pinnacle of the formal education system. How useful is doctoral training in one's later career? In an NSF-funded project, we set out to perform a study of the training, careers, and work activities of Ph.D. physical scientists. The study included both in-depth interviews and a survey sent out to a sample of Ph.D. holders 4-8 years after graduation. Come and find out the results of this study: What skills are most Ph.D. physical scientists using? What should graduate programs be teaching? Are Ph.D.'s who are working in their specific field of training happier than their counterparts working different jobs? What skills and preparation lead to future job satisfaction, perhaps the most important indicator of the "success" of graduate education? A preprint and further details can be found at the project web site at: spot.colorado.edu/ phdcarer.

  3. Dido3 PHD Modulates Cell Differentiation and Division

    Directory of Open Access Journals (Sweden)

    Jovylyn Gatchalian

    2013-07-01

    Full Text Available Death Inducer Obliterator 3 (Dido3 is implicated in the maintenance of stem cell genomic stability and tumorigenesis. Here, we show that Dido3 regulates the expression of stemness genes in embryonic stem cells through its plant homeodomain (PHD finger. Binding of Dido3 PHD to histone H3K4me3 is disrupted by threonine phosphorylation that triggers Dido3 translocation from chromatin to the mitotic spindle. The crystal structure of Dido3 PHD in complex with H3K4me3 reveals an atypical aromatic-cage-like binding site that contains a histidine residue. Biochemical, structural, and mutational analyses of the binding mechanism identified the determinants of specificity and affinity and explained the inability of homologous PHF3 to bind H3K4me3. Together, our findings reveal a link between the transcriptional control in embryonic development and regulation of cell division.

  4. Proceedings of the ICTSS 2012 PhD Workshop - Preface

    DEFF Research Database (Denmark)

    Nielsen, Brian; Weise, Carsten

    2012-01-01

    and their thesis work and receive constructive feedback from experts in the field as well as from peers. Also it is an opportunity for researchers to get an insight into new research topics in the field. Ph.D. students at any stage of their doctoral studies may participate. Seven abstracts were submitted......This technical report contains the proceedings of the Ph.D. Workshop held in conjunction with the The 24th IFIP Int. Conference on Testing Software and Systems (ICTSS'12) in Aalborg, Denmark, November 19, 2012. The well‐established ICTSS series of international conferences addresses the conceptual......, theoretic, and practical challenges of testing software systems, including communication protocols, services, distributed platforms, middleware, embedded systems, and security infrastructures. The aims of the ICTSS Doctoral Workshop is to provide a forum for PhD students to present preliminary results...

  5. Genome-Wide Identification and Analysis of Genes Encoding PHD-Finger Protein in Tomato

    International Nuclear Information System (INIS)

    Hayat, S.; Cheng, Z.; Chen, X.

    2016-01-01

    The PHD-finger proteins are conserved in eukaryotic organisms and are involved in a variety of important functions in different biological processes in plants. However, the function of PHD fingers are poorly known in tomato (Solanum lycopersicum L.). In current study, we identified 45 putative genes coding Phd finger protein in tomato distributed on 11 chromosomes except for chromosome 8. Some of the genes encode other conserved key domains besides Phd-finger. Phylogenetic analysis of these 45 proteins resulted in seven clusters. Most Phd finger proteins were predicted to PML body location. These PHD-finger genes displayed differential expression either in various organs, at different development stages and under stresses in tomato. Our study provides the first systematic analysis of PHD-finger genes and proteins in tomato. This preliminary study provides a very useful reference information for Phd-finger proteins in tomato. They will be helpful for cloning and functional study of tomato PHD-finger genes. (author)

  6. Survey on the Labour Market Position of PhD Graduates: Competence comparison and relation between PhD and current employment

    Energy Technology Data Exchange (ETDEWEB)

    Heuritsch, J.; Waaijer, C.J.F.; Van der Weijden, I.C.M.

    2016-07-01

    We compared the skills PhD graduates acquired during their PhDs to the ones they need in their current job. We also studied the relation between PhD topic and content of the current job of recent PhD graduates. Data was collected in a survey of 1,133 respondents with a PhD from five Dutch universities between early 2008 and mid-2012. We show that scientific skills and independence are developed sufficiently during the PhD education, whereas PhDs are lacking in management and communication skills. These competence discrepancies were compared to the educational level required for the PhD holder’s current job and the relatedness of the current job to the PhD topic. (Author)

  7. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2004-06-01

    Full Text Available

    Report of PhD Dissertations.

    Francesco Barone

    Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Laura Berti Ceroni

    Il territorio e le strutture di Cesarea e Classe tra tarda antichità e alto medioevo in rapporto con Ravenna, Tesi di dottorato di ricerca in Storia e Informatica, Università degli studi di Bologna, 2002-2003.

     

    Marco Bicchierai

    Poppi dalla signoria dei conti Guidi al vicariato del Casentino (1360-1480, Tesi di dottorato in Storia medievale (XIV ciclo, Università degli Studi di Firenze, 2004

     

    Emanuela Garimberti

    Spatiosa ad habitandum loca. Luoghi e identità nella Historia Langobardorum di Paolo Diacono, Tesi di dottorato in Storia medievale (XV ciclo, Università degli Studi di Bologna, 2004

     

    Lorenzo Tanzini

    Sistemi normativi e pratiche istituzionali a Firenze dalla fine del XIII all’inizio del XV secolo, Tesi di dottorato di ricerca in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Stefania Tarquini

    Pellegrinaggio e asseto urbano di Roma, Tesi di dottorato di ricerca in Storia dei centri, delle vie e della cultura dei pellegrinaggi nel Medioevo euro mediterraneo (XV ciclo, Università degli studi di Lecce, 2003

    Segnalazione di tesi di dottorato.

    Francesco Barone

    Istituzioni, società ed economia a Catania nel tardo medioevo (XIV-XV secolo, Tesi di dottorato in Storia medievale (XVI ciclo, Università degli Studi di Firenze, 2004

     

    Laura Berti Ceroni

  8. Microbial analyses of clay and water from different samples from the Mont Terri Rock Laboratory (RL), Switzerland

    International Nuclear Information System (INIS)

    Sergeant, C.; Vesvres, M.H.; Barsotti, V.; Stroes-Gascoyne, S.; Hamon, C.J.; Neble, S.; Shippers, A.; Le Marrec, C.; Vinsot, A.; Schwyn, B.

    2010-01-01

    Document available in extended abstract form only. Exploration of deep subsurface microbial life has increased for very diverse motives. One of them is that these environments are potential host rocks for radioactive waste repositories and that microorganisms may influence geochemical conditions around such sites and migration properties of radionuclides. The pore water Chemistry experiment (PC) was conducted at the Mont Terri-RL to measure in situ the pH, Eh, and other geochemical parameters within the pore water of the Opalinus Clay formation. The borehole for PC was drilled with N 2 under clean but not aseptic conditions, filled immediately with synthetic pore water, which was circulated and monitored for five years. Soon after initiation of PC it was evident that microbial activity affected the borehole water geochemistry. Microbial analyses, including molecular biology and culturing methods, were performed repeatedly during PC (2003-2006), with detailed analysis of water and over-core clay upon termination in 2007. Results indicated the presence of heterotrophic aerobes and anaerobes, nitrate-reducers, iron-reducers, sulphate-reducers and Archaea, which together with geochemical data suggested a reducing environment with sulphate reduction in the water and adjacent clay. A black precipitate containing pyrite and a strong H 2 S smell confirmed the occurrence of sulphate reduction. Specific species identified (> 98% similarity) in PC water included Pseudomonas stutzeri, Bacillus licheniformis, and Desulfosporosinus sp., with similar and additional species (e.g., Trichococcus sp.; Koccuria sp.) in the clay. The origin of these (mostly anaerobic) species cannot be determined with certainty. Some species likely resulted from contamination, but others could be revived species indigenous in the Opalinus Clay. The microbial processes that occurred in PC are not representative of the processes in the undisturbed formation but illustrate the potential for microbial

  9. PhD Dissertations Tesi di dottorato

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Full Text Available Report of PhD Dissertations.Anna Airò La scrittura delle regole. Politica e istituzioni a Taranto nel Quattrocento, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Pasquale Arfé La Clavis Physicae II (316-529 di Honorius Augustodunensis. Studio ed edizione critica, Tesi di dottorato in Storia della filosofia medievale, Università degli Studi di Napoli "L'Orientale", 2005 Alessandro Azzimonti Scrittura agiografica e strutture di potere nell'Italia centro-settentrionale (X-XII secolo, Tesi di dottorato di ricerca in Forme del sapere storico dal medioevo alla contemporaneità, Università degli Studi di Trieste, 2004 Domenico Cerami Il "Confine conteso". Uomini, istituzioni, culture a Monteveglio tra VIII-XII secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Bologna, 2005 Federica Chilà Ostaggi. Uno strumento di pacificazione e governo tra i secoli VIII e XII, Tesi di dottorato di ricerca in Istituzioni, società, religioni dal Tardo Antico alla fine del Medioevo, Università degli Studi di Torino, 2004 Enrico Faini Firenze nei secoli X-XIII: economia e società, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005Alessio FioreStrutture e pratiche del potere signorile in area umbro-marchigiana (secoli XI-XIII, Tesi di dottorato ricerca in Storia, Università degli studi di Pisa, 2004Giampaolo FrancesconiTra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post

  10. Peer Mentorship and Transformational Learning: PhD Student Experiences

    Science.gov (United States)

    Preston, Jane P.; Ogenchuk, Marcella J.; Nsiah, Joseph K.

    2014-01-01

    The purpose of the paper is to describe our peer mentorship experiences and explain how these experiences fostered transformational learning during our PhD graduate program in educational administration. As a literature backdrop, we discuss characteristics of traditional forms of mentorship and depict how our experiences of peer mentorship was…

  11. Ph.D Afhandling: Restaurering verus instaurering og transstaurering

    DEFF Research Database (Denmark)

    Bech-Nielsen, Grith

    2012-01-01

    Ph.d. afhandlingen udforsker holdningen som arkitektfagligt instrument. Fagudøverens "holdning" til værdisætning af arkitektoniske kulturarvsobjekter og til arkitektonisk intervention heri fungerer aktuelt som et anerkendt og konstituerende beslutningsinstrument i praksisnære processer og sammenh...

  12. Governance mode choice in collaborative Ph.D. projects

    NARCIS (Netherlands)

    Salimi, N.; Bekkers, R.N.A.; Frenken, K.

    2015-01-01

    Joint Ph.D. projects are a prominent form of research collaboration, connecting universities to firms and public research organizations. When entering into such collaborations, partners need to make choices regarding a project’s governance. This paper investigates how a university and its partners

  13. Governance mode choice in collaborative PhD projects

    NARCIS (Netherlands)

    Salimi, N.; Bekkers, R.N.A.; Frenken, K.

    2013-01-01

    Joint PhD projects are a promising form of research collaboration, connecting universities to firms and public research organizations. Entering into such collaborations, however, requires decisions in terms of governance. This paper investigates how a university and its partners govern such

  14. PhD by Publication: A Student's Perspective

    Directory of Open Access Journals (Sweden)

    Peter Kanowski

    2008-01-01

    Full Text Available This article presents the first author's experiences as an Australian doctoral student undertaking a PhD by publication in the arena of the social sciences. She published nine articles in refereed journals and a peer-reviewed book chapter during the course of her PhD. We situate this experience in the context of current discussion about doctoral publication practices, in order to inform both postgraduate students and academics in general. The article discusses recent thinking about PhD by publication and identifies the factors that students should consider prior to adopting this approach, in terms of university requirements, supervisors' attitudes, the research subject matter, intellectual property, capacity and working style, and issues of co-authorship. It then outlines our perceptions of the advantages and disadvantages of undertaking a PhD by publication. We suggest that, in general, the advantages outweigh the disadvantages. We conclude by reflecting on how the first author's experiences relate to current discussions about fostering publications by doctoral students.

  15. Consistency and Inconsistency in PhD Thesis Examination

    Science.gov (United States)

    Holbrook, Allyson; Bourke, Sid; Lovat, Terry; Fairbairn, Hedy

    2008-01-01

    This is a mixed methods investigation of consistency in PhD examination. At its core is the quantification of the content and conceptual analysis of examiner reports for 804 Australian theses. First, the level of consistency between what examiners say in their reports and the recommendation they provide for a thesis is explored, followed by an…

  16. Enhancing the skills of PhD supervisors facing internationalization

    DEFF Research Database (Denmark)

    Bøgelund, Pia

    2013-01-01

    interview study within the faculty, and an inquiry into the field of cross-cultural supervision with the purpose of enhancing the skills of PhD supervisors. As is often the case with cross-cultural exchange and inquiry, the study ended up by being just as informative on the supervision cultures and settings...

  17. Measures for Ph.D. Evaluation: The Recruitment Process

    Science.gov (United States)

    D'Agostino, Antonella; Fruzzetti, Stefania; Ghellini, Giulio; Neri, Laura

    2011-01-01

    In the last years the quality of Higher Education (HE) system and its evaluation have been key issues of the political and scientific debate on education policies all over Europe. In the wide landscape that involves the entire HE system we draw attention on the third level of its organization, i.e. the Ph.D. In particular, this paper discusses the…

  18. Supervising the PhD: A Guide to Success.

    Science.gov (United States)

    Delamont, Sara; Atkinson, Paul; Parry, Odette

    This handbook is a practical guide for the novice and experienced supervisor of Ph.D. students focusing on the British system. The book is organized to follow the progress of a student from starting out to a career after the viva voce examination. The chapters are: (1) "A Most Persuasive Piece of Argument"; (2) "Caught and Held by a…

  19. Ph.d. report nº1

    DEFF Research Database (Denmark)

    Hernandez, Lorenzo Banos

    The following report serves as an introduction to the Ph.d subject "Control system Modeling of the Wave Star Energy's Power Take-O". The device studied belongs to the Wave Energy field, which forms part of the renewable hydro Power generation sector. In Denmark, following the succesful course...

  20. PhD thesis: The relationship between expertise and creativity

    DEFF Research Database (Denmark)

    Boysen, Mikkel Snorre Wilms

    2015-01-01

    I Ph.d. projektet undersøges sammenhænge mellem ekspertise og kreativitet via et eksperiment, hvor eksperter og novicer laver musik ved computer. Musikken vurderes efterfølgende af en række fokusgrupper. Studiet peger overraskende på, at novicer på linje med eksperter er i stand til at skabe musi...

  1. PhD Students, Interculturality, Reflexivity, Community and Internationalisation

    Science.gov (United States)

    Holliday, Adrian

    2017-01-01

    Interviews with a small group of doctoral students at a British university indicate that the students feel that the programme provides an environment within which they develop interculturality through reflexive engagement with the PhD community and in some cases with the participants in their research. Significant here is that they are…

  2. Methods of Academic Course Planning for Cancer Biology PhD Students to Enhance Knowledge of Clinical Oncology.

    Science.gov (United States)

    Mattes, Malcolm D; Swart, Elizabeth; Markwell, Steven M; Wen, Sijin; Vona-Davis, Linda C

    2017-09-15

    Little is known about how clinical oncology concepts are taught to PhD students or the most effective methods of doing so. In this study, electronic surveys were sent to faculty and students at PhD training programs, assessing their institution's methods of clinical oncology education and their perspective on optimal approaches to clinical oncology education. Only 40.0% of students reported any clinical oncology component to their institution's training, and only 26.5% had a clinician on their graduate advisory committee. Forty-three percent of students believed that they had a good understanding for translating basic science research into clinical practice, and 77.2% of all participants believed dual degree MD/PhD students were superior to PhD students in this regard. Lectures on clinical oncology research topics were the most valuable type of experience for all participants and were also the most common type of experience utilized. Working with a clinician to develop a clinical trial with correlative endpoints was also highly valued, but was only utilized by approximately 10% of programs. Faculty rated the value of nearly all types of clinical oncology exposure significantly lower than did students. Inclusion of the approaches identified in this study is likely to enhance PhD training in oncology-related disciplines. Cancer Res; 77(18); 4741-4. ©2017 AACR . ©2017 American Association for Cancer Research.

  3. PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing.

    Science.gov (United States)

    Ko, Sae Hee; Nauta, Allison C; Morrison, Shane D; Hu, Michael S; Zimmermann, Andrew S; Chung, Michael T; Glotzbach, Jason P; Wong, Victor W; Walmsley, Graham G; Peter Lorenz, H; Chan, Denise A; Gurtner, Geoffrey C; Giaccia, Amato J; Longaker, Michael T

    2018-01-01

    Cell therapy with mesenchymal stromal cells is a promising strategy for tissue repair. Restoration of blood flow to ischemic tissues is a key step in wound repair, and mesenchymal stromal cells have been shown to be proangiogenic. Angiogenesis is critically regulated by the hypoxia-inducible factor (HIF) superfamily, consisting of transcription factors targeted for degradation by prolyl hydroxylase domain (PHD)-2. The aim of this study was to enhance the proangiogenic capability of mesenchymal stromal cells and to use these modified cells to promote wound healing. Mesenchymal stromal cells harvested from mouse bone marrow were transduced with short hairpin RNA (shRNA) against PHD-2; control cells were transduced with scrambled shRNA (shScramble) construct. Gene expression quantification, human umbilical vein endothelial cell tube formation assays, and wound healing assays were used to assess the effect of PHD knockdown mesenchymal stromal cells on wound healing dynamics. PHD-2 knockdown mesenchymal stromal cells overexpressed HIF-1α and multiple angiogenic factors compared to control (p cells treated with conditioned medium from PHD-2 knockdown mesenchymal stromal cells exhibited increased formation of capillary-like structures and enhanced migration compared with human umbilical vein endothelial cells treated with conditioned medium from shScramble-transduced mesenchymal stromal cells (p cells healed at a significantly accelerated rate compared with wounds treated with shScramble mesenchymal stromal cells (p cells (p cells augments their proangiogenic potential in wound healing therapy. This effect appears to be mediated by overexpression of HIF family transcription factors and up-regulation of multiple downstream angiogenic factors.

  4. Monitoring the Excavation Damaged Zone in Opalinus clay by three dimensional reconstruction of the electrical resistivity in the Mont Terri gallery G-04

    Science.gov (United States)

    Lesparre, N.; Adler, A.; Nicollin, F.; Gibert, D.; Nussbaum, C.

    2012-04-01

    The characteristics of opalinus clay have been studied in the last years for its capacity to retain radionuclide transport as a low permeable rock. This formation presents thereby suitable properties for hosting repository sites of radioactive waste. The Mont Terri underground rock laboratory (Switzerland) has been excavated in opalinus clay layer in order to develop experiences improving the knowledge on the physico-chemical properties of the rock. The study of electrical properties furnishes information on the rock structure, its anisotropy and the changes of these properties with time (Nicollin et al., 2010 ; Thovert et al., 2011). Here the three dimensional reconstruction of the electrical resistivity aims at monitoring the temporal evolution of the excavation damaged zone. Three rings of electrodes have been set-up around the gallery and voltage is measured between two electrodes while a current is injected between two others (Gibert et al., 2006). Measurements have been achieved from July 2004 until April 2008 before, during and after the excavation of the gallery 04. In this study we develop a computational approach to reconstruct three dimensional images of the resistivity in the vicinity of the electrodes. A finite element model is used to represent the complex geometry of the gallery. The measurements inferred from a given resistivity distribution are estimated using the software EIDORS (Adler and Lionheart, 2006), this constitutes the forward problem. The reconstruction of the media resistivity is then implemented by fitting the estimated to the measured data, via the resolution of an inverse problem. The parameters of this inverse problem are defined by mapping the forward problem elements into a coarser mesh. This allows to reduce drastically the number of unknowns and so increases the robustness of the inversion. The inversion is executed with the conjugate gradient method regularised by an analysis of the Jacobian singular values. The results show an

  5. A model perception on the independence of PhD students in ...

    African Journals Online (AJOL)

    Rwandan Journal of Education ... As results, we suggest that a well-trained independent PhD student from UR should be able to think critically, to initiate, to innovate and to enhance the research capabilities. Therefore ... Keywords: PhD supervision, independent researcher, PhD student, research capability, critical thinking ...

  6. How Prepared Are MSW Graduates for Doctoral Research? Views of PhD Research Faculty

    Science.gov (United States)

    Drisko, James W.; Evans, Kristin

    2018-01-01

    This national survey of PhD faculty assessed the research preparation of entering doctoral social work students on a wide range of research knowledge and related skills. The prior literature shows that PhD programs repeat much BSW and MSW research course content. This study shows that the trend continues and has perhaps widened. PhD research…

  7. Electrical tomography monitoring of the EDZ during the excavation of the gallery Ga08 in the Mont Terri URL

    International Nuclear Information System (INIS)

    Nicollin, Florence; Gibert, Dominique; Lesparre, Nolwenn; Nussbaum, Christophe

    2010-01-01

    Document available in extended abstract form only. In the Mont Terri Underground Rock Laboratory, the excavation of the new gallery Ga08 provided a unique opportunity to monitor the excavation damaged zone (EDZ) in the Opalinus clay, at time scales ranging from hours to months. The excavation of the gallery Ga08 has started from the northern end of the URL and has progressed towards the South, ending by the junction with the end of the gallery Ga04. Several geophysical and geochemical methods were performed from the end face of the gallery Ga04, to observe the evolution of the rock mass located in the so-called EZ-G08 section during the progress of the excavation. Thus, electrical resistivity measurements were performed, with electrodes placed both on the Ga04 face and in boreholes perpendicular to the face. These experiments revealed a strong anisotropy of the electrical resistivity of the rock mass, and they allowed to study the temporal evolution of the electrical resistivity in the EDZ. An array of more than 700 electrodes was installed on the rough face according to a square mesh with a mean side of 30 cm. On each line of the mesh, the electrodes were equally spaced every 15 cm. 4 horizontal boreholes, 8 m long and 56 mm in diameter, were equipped with lines of 64 electrodes equally spaced every 5 cm. Finally, 2 groups of 4 boreholes, 1 m long and spaced about 20 cm, were equipped with lines of 16 electrodes equally spaced every 5 cm. Using the electrode array of the face, Wenner profiles were acquired along both the horizontal and the vertical lines, highlighting a strong anisotropy of electrical resistivity since the values depend on the direction in which they are measured. In order to characterize this anisotropy, other measurements were done using the array of the face and the lines of the short boreholes, with the so-called square array configuration where the electrodes are located at the corners of squares with different orientations. On the face

  8. Mont Terri Project - Engineered barrier emplacement experiment in Opalinus Clay for the disposal of radioactive waste in underground repositories

    International Nuclear Information System (INIS)

    Mayor, J. C.; Garcia-Sineriz, J.; Alonso, E.; Alheid, H.-J.; Bluemling, P.

    2007-01-01

    The Engineered Barrier (EB) experiment was a full-scale test for the demonstration, in a horizontal drift, of an emplacement technics of the clay barrier, using a granular bentonite material in the upper part of this barrier and bentonite blocks at the bottom. The test has been carried out in a 6 m long section of a niche excavated in Opalinus Clay of the Mont Terri underground laboratory. A steel dummy canister, with the same dimensions and weight as the real reference canisters, was placed on top of a bed of highly compacted bentonite blocks (in turn lying on a concrete bed), and the rest of the clay barrier volume was backfilled with a Granular Bentonite Material (GBM), made of very highly compacted pellets of different sizes. Hydro-mechanical instrumentation and an artificial hydration system (to accelerate the saturation of the clay barrier) were installed, and the test section sealed with a concrete plug. The evolution of the hydro-mechanical parameters along the hydration, both in the barrier and in the clayey rock formation, has been monitored during about 1.5 years, and modelled using the CODE-BRIGHT code. The EB experiment has proved that fully automated production of a Granular Bentonite Material (GBM) is possible and large quantities can be produced in due time in the required quality. Only minor modifications of existing production lines in industry for other applications were necessary to achieve this result. In the EB test section, a dry density of 1.36 g/cm 3 of the emplaced GBM has been obtained. With this value it is estimated that the hydraulic conductivity of this material is lower than 5 x 10 -12 m/s and the swelling pressure is about 1.3 MPa. Even though the EB test section conditions are now not considered as representative of a true demonstration, it is deemed that the model emplacement testing results (dry density of about 1.40 g/cm 3 ) serve well to demonstrate the achievable densities expected in the real world setting. The artificial

  9. Mont Terri Project - Engineered barrier emplacement experiment in Opalinus Clay for the disposal of radioactive waste in underground repositories

    Energy Technology Data Exchange (ETDEWEB)

    Mayor, J. C. [Empresa Nacional de Residuos Radioactivos SA (ENRESA), Madrid (Spain); Garcia-Sineriz, J. [Asociacion para la Investigacion y Desarollo Industrial de los Recursos Naturales (AITEMIN), Madrid (Spain); Alonso, E. [Centre Internacional de Metodos Numerics en Ingenyeria (CIMNE), Barcelona (Spain); Alheid, H.-J. [Bundesanstalt fuer Geowissenschaften und Rohstoffe (BGR), Hannover (Germany); Bluemling, P. [National Cooperative for the Disposal of Radioactive Waste (Nagra), Wettingen (Switzerland)

    2007-07-01

    The Engineered Barrier (EB) experiment was a full-scale test for the demonstration, in a horizontal drift, of an emplacement technics of the clay barrier, using a granular bentonite material in the upper part of this barrier and bentonite blocks at the bottom. The test has been carried out in a 6 m long section of a niche excavated in Opalinus Clay of the Mont Terri underground laboratory. A steel dummy canister, with the same dimensions and weight as the real reference canisters, was placed on top of a bed of highly compacted bentonite blocks (in turn lying on a concrete bed), and the rest of the clay barrier volume was backfilled with a Granular Bentonite Material (GBM), made of very highly compacted pellets of different sizes. Hydro-mechanical instrumentation and an artificial hydration system (to accelerate the saturation of the clay barrier) were installed, and the test section sealed with a concrete plug. The evolution of the hydro-mechanical parameters along the hydration, both in the barrier and in the clayey rock formation, has been monitored during about 1.5 years, and modelled using the CODE-BRIGHT code. The EB experiment has proved that fully automated production of a Granular Bentonite Material (GBM) is possible and large quantities can be produced in due time in the required quality. Only minor modifications of existing production lines in industry for other applications were necessary to achieve this result. In the EB test section, a dry density of 1.36 g/cm{sup 3} of the emplaced GBM has been obtained. With this value it is estimated that the hydraulic conductivity of this material is lower than 5 x 10{sup -12} m/s and the swelling pressure is about 1.3 MPa. Even though the EB test section conditions are now not considered as representative of a true demonstration, it is deemed that the model emplacement testing results (dry density of about 1.40 g/cm{sup 3}) serve well to demonstrate the achievable densities expected in the real world setting. The

  10. Geomechanical analysis of excavation-induced rock mass behavior of faulted Opalinus clay at the Mont Terri underground rock laboratory (Switzerland)

    International Nuclear Information System (INIS)

    Thoeny, R.

    2014-01-01

    Clay rock formations are potential host rocks for deep geological disposal of nuclear waste. However, they exhibit relatively low strength and brittle failure behaviour. Construction of underground openings in clay rocks may lead to the formation of an excavation damage zone (EDZ) in the near-field area of the tunnel. This has to be taken into account during risk assessment for waste-disposal facilities. To investigate the geomechanical processes associated with the rock mass response of faulted Opalinus Clay during tunnelling, a full-scale ‘mine-by’ experiment was carried out at the Mont Terri Underground Rock Laboratory (URL) in Switzerland. In the ‘mine-by’ experiment, fracture network characteristics within the experimental section were characterized prior to and after excavation by integrating structural data from geological mapping of the excavation surfaces and from four pre- and post-excavation boreholes.The displacements and deformations in the surrounding rock mass were measured using geo-technical instrumentation including borehole inclinometers, extensometers and deflectometers, together with high-resolution geodetic displacement measurements and laser scanning measurements on the excavation surfaces. Complementary data was gathered from structural and geophysical characterization of the surrounding rock mass. Geological and geophysical techniques were used to analyse the structural and kinematic relationships between the natural and excavation-induced fracture network surrounding the ‘mine-by’ experiment. Integrating the results from seismic refraction tomography, borehole logging, and tunnel surface mapping revealed that spatial variations in fault frequency along the tunnel axis alter the rock mass deformability and strength. Failure mechanisms, orientation and frequency of excavation-induced fractures are significantly influenced by tectonic faults. On the side walls, extensional fracturing tangential to the tunnel circumference was the

  11. Geomechanical analysis of excavation-induced rock mass behavior of faulted Opalinus clay at the Mont Terri underground rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Thoeny, R.

    2014-07-01

    Clay rock formations are potential host rocks for deep geological disposal of nuclear waste. However, they exhibit relatively low strength and brittle failure behaviour. Construction of underground openings in clay rocks may lead to the formation of an excavation damage zone (EDZ) in the near-field area of the tunnel. This has to be taken into account during risk assessment for waste-disposal facilities. To investigate the geomechanical processes associated with the rock mass response of faulted Opalinus Clay during tunnelling, a full-scale ‘mine-by’ experiment was carried out at the Mont Terri Underground Rock Laboratory (URL) in Switzerland. In the ‘mine-by’ experiment, fracture network characteristics within the experimental section were characterized prior to and after excavation by integrating structural data from geological mapping of the excavation surfaces and from four pre- and post-excavation boreholes.The displacements and deformations in the surrounding rock mass were measured using geo-technical instrumentation including borehole inclinometers, extensometers and deflectometers, together with high-resolution geodetic displacement measurements and laser scanning measurements on the excavation surfaces. Complementary data was gathered from structural and geophysical characterization of the surrounding rock mass. Geological and geophysical techniques were used to analyse the structural and kinematic relationships between the natural and excavation-induced fracture network surrounding the ‘mine-by’ experiment. Integrating the results from seismic refraction tomography, borehole logging, and tunnel surface mapping revealed that spatial variations in fault frequency along the tunnel axis alter the rock mass deformability and strength. Failure mechanisms, orientation and frequency of excavation-induced fractures are significantly influenced by tectonic faults. On the side walls, extensional fracturing tangential to the tunnel circumference was the

  12. Qualitative methods in PhD theses from general practice in Scandinavia

    DEFF Research Database (Denmark)

    Malterud, Kirsti; Hamberg, Katarina; Reventlow, Susanne

    2017-01-01

    . Qualitative studies are often included in Ph.D. theses from general practice in Scandinavia. Still, the Ph.D. programs across nations and institutions offer only limited training in qualitative methods. In this opinion article, we draw upon our observations and experiences, unpacking and reflecting upon...... values and challenges at stake when qualitative studies are included in Ph.D. theses. Hypotheses to explain these observations are presented, followed by suggestions for standards of evaluation and improvement of Ph.D. programs. The authors conclude that multimethod Ph.D. theses should be encouraged...

  13. Postgraduate research training: the PhD and MD thesis.

    Science.gov (United States)

    Higginson, I; Corner, J

    1996-04-01

    Higher research degrees, such as the PhD, MPhil and MD, have existed within universities for 80 years or more, although the differences between the MD and PhD remain confused. A higher research degree training provides individuals with greater research knowledge and skills, and benefits the specialty. Concern exists about the levels of supervision sometimes provided, failure to complete degrees, and the variable levels of research knowledge and skills attained. We propose that higher research degrees in palliative care have four functions: extending personal scholarship, generating knowledge, training for the individual and contributing to the growth of the specialty. Such an approach may include: a formalised first year with taught components such as in research MSc programmes, formal supervision and progress assessment. In palliative care, clinical and academic approaches need greater integration. Multiprofessional learning is essential. To allow individuals to undertake higher research degree programmes, fellowships or specific funding are needed.

  14. Biomedical PhD education - an international perspective

    DEFF Research Database (Denmark)

    Mulvany, Michael J.

    2013-01-01

    tenured university positions. However, over the past 20–30 years, and particularly the past 10 years, the situation has changed dramatically. Governments in many countries have invested massively in PhD education, believing that trained researchers will contribute to the ‘knowledge society’, and thus...... during their PhD studies. The purpose of this article is to explore how this seeming paradox is being addressed in biomedicine and to show that far from being inconsistent that the two aspects are in fact complementary. The article is based on the author’s experience as Head of Aarhus Graduate School...... of Health Sciences 2002–2011 and his work with graduate schools across Europe and internationally through the organization ORPHEUS....

  15. Iterative Mixture Component Pruning Algorithm for Gaussian Mixture PHD Filter

    Directory of Open Access Journals (Sweden)

    Xiaoxi Yan

    2014-01-01

    Full Text Available As far as the increasing number of mixture components in the Gaussian mixture PHD filter is concerned, an iterative mixture component pruning algorithm is proposed. The pruning algorithm is based on maximizing the posterior probability density of the mixture weights. The entropy distribution of the mixture weights is adopted as the prior distribution of mixture component parameters. The iterative update formulations of the mixture weights are derived by Lagrange multiplier and Lambert W function. Mixture components, whose weights become negative during iterative procedure, are pruned by setting corresponding mixture weights to zeros. In addition, multiple mixture components with similar parameters describing the same PHD peak can be merged into one mixture component in the algorithm. Simulation results show that the proposed iterative mixture component pruning algorithm is superior to the typical pruning algorithm based on thresholds.

  16. Academic PHD School at Faculty of Agriculture in Tirana, Albania.

    Science.gov (United States)

    Bijo, B; Hoda, A; Thamaj, F

    2010-01-01

    Agricultural University of Tirana (AUT) is one of 12 public Universities in Albania. There are five Faculties within AUT. The study courses in AUT except of Faculty of Veterinary Medicine, are organized in three levels. Courses of the first level offer the fundamental knowledge. The students at the end of this cycle own 180 credits and obtain a first level diploma. In the second level study courses, the students get deeper theoretical and practical knowledge and modules are spread across 120 credits. At the end of this level the students obtain a second level diploma, according to the study course. In FVM, the study courses are organized as integrated program of second level that is spread across 300 credits. The students, who have finished the first level course, may go further in "Master of First level" for a professional training, where they do obtain 60 credits. The program of third cycle includes the courses of "Master of Second level" and the programs of PhD. The course of "Master of second level" is offered to the students who have achieved a Diploma of Second Level, and the students get deeper knowledge of scientific and professional character and do obtain at least 60 credits. PhD programs have totally an academic character. The principal aspect is the research and independent scientific activity. This program can be followed by the students who have a diploma of second level, or a diploma of "Master of Second level". The PhD program is organized in four years. The first year, consists of theoretical knowledge of the students. The second year is mainly research. The third year is research, data manipulation, publications, oral presentations and the last year is compilation of PhD thesis, its presentation and defense. Here is presented newly established doctoral school at Faculty of Agriculture and Environment.

  17. Lynn Sorbara, PhD | Division of Cancer Prevention

    Science.gov (United States)

    Dr. Lynn Sorbara earned her PhD from Albert Einstein College of Medicine in 1986. Her thesis research was in the areas of the mechanism of action of the drug, Taxol, and of multidrug resistance. After postdoctoral fellowships at the Rockefeller University and the Mount Sinai College of Medicine in Manhattan, she came to the NIH as a Senior Staff Fellow in the Diabetes Branch

  18. The PhD track: who succeeds, who drops out?

    OpenAIRE

    Groenvynck, Hans; Vandevelde, Karen; Van Rossem, Ronan

    2013-01-01

    Doctoral completion rates are an indicator of successful doctoral programmes and of a region's potential of highly skilled workforce. The Human Resources in Research - Flanders (HRRF) database contains data of all academic staff appointments, doctoral student registrations, and doctoral degrees of all Flemish universities from 1990 onwards. Previous research has identified the following factors as affecting successfully completing the PhD: cohort, scientific discipline, type of scholarship or...

  19. Researcher Profile: An Interview with Sarah Asebedo, Ph.D.

    OpenAIRE

    Martie Gillen

    2016-01-01

    Sarah Asebedo, Ph.D., CFP®, is an Assistant Professor of Personal Financial Planning with Texas Tech University. With extensive financial planning practitioner experience, her goal is to connect research and financial planning practice with a focus on the relationship between psychological attributes, financial conflicts, and financial behavior. Her work has been published in the Journal of Financial Planning, Journal of Financial Therapy, Journal of Financial Counselin...

  20. Instructable autonomous agents. Ph.D. Thesis

    Science.gov (United States)

    Huffman, Scott Bradley

    1994-01-01

    In contrast to current intelligent systems, which must be laboriously programmed for each task they are meant to perform, instructable agents can be taught new tasks and associated knowledge. This thesis presents a general theory of learning from tutorial instruction and its use to produce an instructable agent. Tutorial instruction is a particularly powerful form of instruction, because it allows the instructor to communicate whatever kind of knowledge a student needs at whatever point it is needed. To exploit this broad flexibility, however, a tutorable agent must support a full range of interaction with its instructor to learn a full range of knowledge. Thus, unlike most machine learning tasks, which target deep learning of a single kind of knowledge from a single kind of input, tutorability requires a breadth of learning from a broad range of instructional interactions. The theory of learning from tutorial instruction presented here has two parts. First, a computational model of an intelligent agent, the problem space computational model, indicates the types of knowledge that determine an agent's performance, and thus, that should be acquirable via instruction. Second, a learning technique, called situated explanation specifies how the agent learns general knowledge from instruction. The theory is embodied by an implemented agent, Instructo-Soar, built within the Soar architecture. Instructo-Soar is able to learn hierarchies of completely new tasks, to extend task knowledge to apply in new situations, and in fact to acquire every type of knowledge it uses during task performance - control knowledge, knowledge of operators' effects, state inferences, etc. - from interactive natural language instructions. This variety of learning occurs by applying the situated explanation technique to a variety of instructional interactions involving a variety of types of instructions (commands, statements, conditionals, etc.). By taking seriously the requirements of flexible

  1. Researcher Profile: An Interview with Sonya Britt, Ph.D., CFP, AFC

    Directory of Open Access Journals (Sweden)

    Sonya Britt

    2013-08-01

    Full Text Available Sonya Britt, Ph.D., CFP, AFC graduated from Texas Tech University in 2010 with a doctorate in Personal Financial Planning. Her first two degrees are from Kansas State University in Personal Financial Planning (B.S. and Marriage and Family Therapy (M.S.. and she was the founding president of the Financial Therapy Association and recently retired from the board as past-president. She currently serves on the board of the American Council on Consumer Interests association. Sonya is an associate editor for the Journal of Family and Economic Issues and on the editorial board of the Journal of Financial Therapy and on the international scientific board of the Italian Journal of Sociology of Education.

  2. Biogeochemical processes in a clay formation in situ experiment: Part E - Equilibrium controls on chemistry of pore water from the Opalinus Clay, Mont Terri Underground Research Laboratory, Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Pearson, F.J., E-mail: fjpearson@gmail.com [Ground-Water Geochemistry, 5108 Trent Woods Dr., New Bern, NC 28562 (United States); Tournassat, Christophe; Gaucher, Eric C. [BRGM, B.P. 36009, 45060 Orleans Cedex 2 (France)

    2011-06-15

    Highlights: > Equilibrium models of water-rock reactions in clay rocks are reviewed. > Analyses of pore waters of the Opalinus Clay from boreholes in the Mont Terri URL, Switzerland, are tabulated. > Results of modelling with various mineral controls are compared with the analyses. > Best agreement results with calcite, dolomite and siderite or daphnite saturation, Na-K-Ca-Mg exchange and/or kaolinite, illite, quartz and celestite saturation. > This approach allows calculation of the chemistry of pore water in clays too impermeable to yield water samples. - Abstract: The chemistry of pore water (particularly pH and ionic strength) is an important property of clay rocks being considered as host rocks for long-term storage of radioactive waste. Pore waters in clay-rich rocks generally cannot be sampled directly. Instead, their chemistry must be found using laboratory-measured properties of core samples and geochemical modelling. Many such measurements have been made on samples from the Opalinus Clay from the Mont Terri Underground Research Laboratory (URL). Several boreholes in that URL yielded water samples against which pore water models have been calibrated. Following a first synthesis report published in 2003, this paper presents the evolution of the modelling approaches developed within Mont Terri URL scientific programs through the last decade (1997-2009). Models are compared to the composition of waters sampled during dedicated borehole experiments. Reanalysis of the models, parameters and database enabled the principal shortcomings of the previous modelling efforts to be overcome. The inability to model the K concentrations correctly with the measured cation exchange properties was found to be due to the use of an inappropriate selectivity coefficient for Na-K exchange; the inability to reproduce the measured carbonate chemistry and pH of the pore waters using mineral-water reactions alone was corrected by considering clay mineral equilibria. Re

  3. Feasibility study for the preparation of a twin-hole disposal configuration test at the Mont Terri URL - MACH-2. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Jobmann, M.; Wolf, J.

    2009-08-15

    The German Federal Government has announced that research and development activities concerning final repositories for high-level waste are to focus on clay formations as host rock in order to investigate alternatives to salt rock which is favoured in the current reference concept. Within the scope of design calculations for a final repository in clay formations, thermohydro-mechanical interaction effects have thus been studied, but only based on numerical calculation. The currently preferred disposal concept is based on the emplacement of heat-generating waste in vertical boreholes with a depth of 50 m maximum. How strongly thermally induced interaction between adjacent emplacement boreholes affects a system of vertical boreholes in claystone has not yet been investigated in-situ. However, these interaction effects need to be considered as in a real repository the emplacement boreholes are drilled successively and, depending on the delivery and necessary cooling-off time of the containers at the interim storage facility, are filled at corresponding intervals. The main goal of the suggested in-situ experiment is to investigate the THM interaction of two adjacent emplacement boreholes that are filled and heated at different times. The project is to be planned and carried out jointly by DBE TECHNOLOGY GmbH and GRS. The Federal Institute for Geosciences and Natural Resources (GBR) has declared its interest in participating. A location for this experiment has been found at the underground research laboratory in Mont Terri, Switzerland, which is located in an Opalinus-clay formation. The project has been presented to the Mont Terri consortium, and a positive vote to carry out the experiment was obtained. The exact location of the experiment has been set within the so-called ''sandy facies'' of the rock lab which is similar to the German part of the Opalinus clay. Since time and costs involved in such a major project cannot be reliably estimated

  4. Erythropoietin inhibits HIF-1α expression via upregulation of PHD-2 transcription and translation in an in-vitro model of hypoxia ischemia

    Science.gov (United States)

    Souvenir, Rhonda; Flores, Jerry J.; Ostrowski, Robert P.; Manaenko, Anatol; Duris, Kamil; Tang, Jiping

    2014-01-01

    Hypoxia inducible factor (HIF)-1α is the central transcriptional factor for the regulation of oxygen-associated genes in response to hypoxia. Erythropoietin (EPO), a hematopoietic growth factor, increases oxygen availability during hypoxia/ischemia and is associated with neuroprotection following hypoxia ischemia in laboratory models of stroke. However, EPO has failed to translate in a clinical setting. Thus it is critical to elucidate the key players in EPO-induced neuroprotection. Our preliminary studies have shown that EPO, as a downstream gene of hypoxia inducible factor (HIF), inhibits HIF-1α in a dose-dependent manner in an in-vitro model of hypoxia ischemia. This study is designed to elucidate the primary mediator of EPO-induced HIF-1α inhibition and subsequent cell survival/neuroprotection. Oxygen and glucose deprivation (OGD) of nerve growth factor (NGF) differentiated rat pheochromocytoma (PC-12) cells were used to model hypoxia ischemia in an in vitro environment. The profile of HIF-1α, HIF-2α and PHD-2 expression, HIF-1α and prolyl hydroxylase (PHD-2) mRNA levels, MMP-9 and cell death was evaluated in the presence and absence of either EPO or PHD-2 inhibitor during OGD. Our findings showed that EPO treatment resulted in an increase in PHD-2 transcription and translation, inhibition of HIF-1α expression, reactive oxygen species (ROS) formation and matrix metalloproteinase (MMP)-9 activity, resulting in increased cell survival after OGD. We also observed that EPO-induced cell survival/neuroprotection was reversed by siRNA silencing of PHD-2. This led to the conclusion that PHD-2 is a key mediator of EPO-induced HIF-1α inhibition and subsequent neuroprotection in an in vitro model of hypoxia ischemia. PMID:24323731

  5. Erythropoietin inhibits HIF-1α expression via upregulation of PHD-2 transcription and translation in an in vitro model of hypoxia-ischemia.

    Science.gov (United States)

    Souvenir, Rhonda; Flores, Jerry J; Ostrowski, Robert P; Manaenko, Anatol; Duris, Kamil; Tang, Jiping

    2014-02-01

    Hypoxia inducible factor (HIF)-1α is the central transcriptional factor for the regulation of oxygen-associated genes in response to hypoxia. Erythropoietin (EPO), a hematopoietic growth factor, increases oxygen availability during hypoxia/ischemia and is associated with neuroprotection following hypoxia-ischemia in laboratory models of stroke. However, EPO has failed to translate in a clinical setting. Thus, it is critical to elucidate the key players in EPO-induced neuroprotection. Our preliminary studies have shown that EPO, as a downstream gene of HIF, inhibits HIF-1α in a dose-dependent manner in an in vitro model of hypoxia-ischemia. This study is designed to elucidate the primary mediator of EPO-induced HIF-1α inhibition and subsequent cell survival/neuroprotection. Oxygen and glucose deprivation (OGD) of nerve growth factor-differentiated rat pheochromocytoma (PC-12) cells were used to model hypoxia-ischemia in an in vitro environment. The profile of HIF-1α, HIF-2α and prolyl hydroxylase domain 2 (PHD-2) expression; HIF-1α and prolyl hydroxylase (PHD-2) mRNA levels; matrix metalloproteinase (MMP)-9; and cell death was evaluated in the presence and absence of either EPO or PHD-2 inhibitor during OGD. Our findings showed that EPO treatment resulted in an increase in PHD-2 transcription and translation, inhibition of HIF-1α expression, reactive oxygen species formation, and MMP-9 activity, resulting in increased cell survival after OGD. We also observed that EPO-induced cell survival/neuroprotection was reversed by siRNA silencing of PHD-2. This led to the conclusion that PHD-2 is a key mediator of EPO-induced HIF-1α inhibition and subsequent neuroprotection in an in vitro model of hypoxia-ischemia.

  6. MS PHD'S Professional Development Program: A Scientific Renaissance in Cyberspace

    Science.gov (United States)

    Powell, J. M.; Williamson, V. A.; Griess, C. A.; Pyrtle, A. J.

    2004-12-01

    This study is a component of a four-year investigation of MS PHD'S Professional Development Program's virtual community through the lenses of underrepresented minority students in Earth system science and engineering fields. In this presentation, the development, assessment and projected utilization of the ongoing study will be discussed. The overall goal of this study is to examine the effectiveness of virtual team building methods and understand how the development of a communal cyberinfrastructure acts as an integral part of the emergence of a Scientific Renaissance. The exemplar, Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S), provides professional development experiences to facilitate the advancement of students of color achieving outstanding Earth system careers. Undergraduate and graduate students are supported through access to scientific conferences, mentorship and virtual community building. Framed by critical theory, this ethnographic exploration uses a mixed methods research design to record, observe, and analyze both the processes and products of the website, listserv and synchronous web-based dialogue. First, key findings of the formative evaluation and annual reports of the successfully implemented 2003 MS PHD'S Pilot Project are presented. These findings inform future evaluations of the use of technological resources and illustrate how this public space provides peer support and enriched research opportunities. Quantitative methods such as statistical analysis, academic and professional tracking and evaluative tools for scientific content and competency are complimented by qualitative methods that include observations, heuristic case studies and focus group interviews. The findings of this ongoing investigation will provide insight on how national organizations, higher education practitioners, community-based support systems and underrepresented minorities in the sciences promote diversity by developing

  7. Researcher Profile: An Interview with Virginia Solis Zuiker, Ph.D.

    Directory of Open Access Journals (Sweden)

    Virginia Solis Zuiker

    2015-12-01

    Full Text Available Virginia Solis Zuiker is an Associate Professor in the Department of Family Social Science at the University of Minnesota. She teaches courses on personal and family finance, family financial counseling, family resource management, economic perspectives of families, and family decision-making. Her scholarly research focus is in the area of economic well-being of families with particular interest in self-employment and family-owned businesses. Her research focuses on the Hispanic family life and she is the author of “Hispanic Self-Employment in the Southwest: Rising Above the Threshold of Poverty,” (Garland Publishing, 1997. She received her B.S. from the University of North Texas, an M.S. from Texas Tech University, and a Ph.D. from The Ohio State University. She served three years on the Board of Directors for the Association of Financial Counseling and Planning Education.

  8. Financial Law (By: Lecturer PhD Cosmin Flavius Costas)

    OpenAIRE

    Bostan, Ionel

    2018-01-01

    Through these lines we will stop on a specialty written by a young university student, an exponent of the Superior Law School in Cluj-Napoca. This is the book entitled Drept Financiar [Financial Law], published by Lecturer PhD Cosmin Flavius Costas. On the volume entitled Financial Law, which was published at the end of the year 2016 (ISBN:978-606-673-816-3, Pages: 396) we mention here a radiography "made from four perspectives - national finances, local finance, social security finances and ...

  9. Mladen Zrinjski, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Tomislav Bašić

    2010-12-01

    Full Text Available Mladen Zrinjski defended his PhD thesis Defining the Calibration Baseline Scale of the Faculty of Geodesy by Applying Precise Electro-Optical Distance Meter and GPS at the Faculty of Geodesy of the University of Zagreb on April 8, 2010. The Defence Committee included Prof. Dr. Vedran Mudronja from the Faculty of Mechanical Engineering and Naval Architecture of the University of Zagreb, Prof. Dr. Tomislav Bašić (mentor 1 and Prof. Emeritus Nikola Solarić (mentor 2.

  10. Hrvoje Tomić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Siniša Mastelić Ivić

    2010-12-01

    Full Text Available Hrvoje Tomić defended his PhD thesis Geospatial Data Analysis for the Purpose of Real Estate Valuation in Urban Areas at the Faculty of Geodesy, University of Zagreb, on November 15, 2010. His mentor was Prof. Dr. Siniša Mastelić Ivić, and the other two members of the Grading and Defence Committee were Assist. Prof. Dr. Vlado Cetl and Prof. Dr. Goran Poljanec from the Faculty of Civil Engineering, University of Zagreb.

  11. Communication and information-seeking behavior of PhD students in physicists and astronomy

    OpenAIRE

    Jamali, Hamid R.

    2006-01-01

    As a part of a wider doctoral research, this paper deals with the communication and information-seeking behavior of research (PhD) students in physics and astronomy. Based on a qualitative case study of PhD students in the Department of Physics and Astronomy at University College London, this study seeks to derive behavioral patterns in information-seeking activities of PhD students. The study aims to investigate the intradisciplinary differences in information-seeking activities of physicist...

  12. Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Beyond the PhD Professional Development Program: A Pilot Project

    Science.gov (United States)

    Johnson, A.; Jearld, A.; Williamson Whitney, V.; Huggans, M.; Ricciardi, L.; Thomas, S. H.; Jansma, P. E.

    2012-12-01

    In 2011 the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S)® initiative launched its newest activity entitled the MS PHD'S "Beyond the PhD (B-PhD) Professional Development Program." This exciting new program was designed to facilitate the development of a new community of underrepresented minority (URM) doctoral candidates and recent doctorate degree recipients in Earth system science (ESS)-related fields. The MS PHD'S B-PhD provides customized support and advocacy for MS PHD'S B-PhD participants in order to facilitate smoother and informed transitions from graduate school, to postdoctoral and tenure-track positions, as well as other "first" jobs in government, industry, and non-profit organizations. In November 2011 the first cohort of MS PHD'S B-PhD participants engaged in intensive sessions on the following topics: "Toolkits for Success for Academia, Business/Industry, Federal Government and Non-Profits", "Defining Short, Mid and Long Term Career Goals", "Accessing and Refining Skill Sets and Other Door Openers", "International Preparation and Opportunities", "Paying it Forward/Lifting as You Climb", and "Customized Strategies for Next Steps". This pilot event, which was hosted by the University of Texas at Arlington's (UTA) College of Science, also provided opportunities for participants to serve as guest lecturers in the UTA's Colleges of Science and Engineering and included one-on-one discussions with MS PHD'S B-PhD mentors and guest speakers who are well established within their individual ESS fields. Insights regarding opportunities, challenges and obstacles commonly faced by URMs within the ESS fields, as well as strategies for success were shared by MS PHD'S B-PhD mentors and guest speakers. Survey results indicate that MS PHD'S B-PhD participants appreciated not only the material covered during this pilot activity, but also appreciated the opportunity to become part of a community of young URM ESS

  13. Mentored peer reviewing for PhD faculty and students.

    Science.gov (United States)

    Xu, Jiayun; Kim, Kyounghae; Kurtz, Melissa; Nolan, Marie T

    2016-02-01

    There is a need for scholars to be prepared as peer reviewers in order to ensure the continual publication of quality science. However, developing the skills to craft a constructive critique can be difficult. In this commentary, we discuss the use of a group peer review mentoring model for PhD students to gain experience in peer review from a faculty member who is experienced in peer review. Central to this model, was the opportunity for each student and faculty mentor to openly discuss their critique of the manuscript. Through this enriching experience, novice researchers were able to learn the elements of a good peer review, better determine a manuscript's substantive contribution to science, and advance the quality of their own manuscript writing. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. PhD Thesis: Functional Textiles in Hospital Interiors

    DEFF Research Database (Denmark)

    Mogensen, Jeppe Emil

    The PhD thesis explores the possibilities and design qualities of using functional textiles in the interior of hospital environments, and is the result of a three-year collaboration between Aalborg University, Department of Civil Engineering, and VIA University College, VIA Design. The thesis...... years, knowledge on the use of interior materials and textiles are still rather limited. Contemporary hospital design has been widely criticised of being too institutional and clinical, and one of the main reasons for this experience may be related to the use of ‘cold’, hard-surfaced materials...... of plastic, vinyl and steel. These materials also dominate the new hospitals, designed and constructed these years, and despite the increased focus on the design concept healing architecture, the rational requirements of ef cient cleaning and maintenance still seems to direct the interior design of hospital...

  15. Denis Radoš, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Damir Magaš

    2017-12-01

    Full Text Available Denis Radoš, MSc in Geography, and assistant and junior researcher at the Chair for Cartography and Geographic Information Systems (GIS at the Department of Geography of the University of Zadar, has successfully defended his PhD thesis entitled Topography Analysis in the Wind Estimation Process within the doctoral studies in The Adriatic – A Link Between Continents organized by the Department of History and the Department of Geography of the University of Zadar. The thesis was defended in the Rectorate of the University of Zadar before a commission comprising Assoc. Prof. Dr. Sanja Lozić, chairperson, Full Professor with tenure Dr. Damir Magaš, mentor, and Assist. Prof. Dr. Mladen Pahernik.

  16. Researcher Profile: An Interview with Jodi Letkiewicz, Ph.D.

    Directory of Open Access Journals (Sweden)

    Jodi Letkiewicz

    2014-12-01

    Full Text Available Jodi Letkiewicz, Ph.D., is an assistant professor of finance at York University in Toronto, Ontario. She teaches in the Certified Financial Planner® Core Curriculum program preparing undergraduate students for the Canadian CFP® certification and conducts research in several areas of personal finance and consumer decision-making, including behavioral aspects influencing the decision to seek financial help, how personality traits affect financial decision-making, and the financial state of young adults, including the impact student loans have on overall well-being and financial milestones early in their adult life. Dr. Letkiewicz’s goal is to increase financial well-being in the general public, which she hopes to accomplish through teaching, research, and community outreach.

  17. Attitude of PhD Students Towards Academic Dishonesty

    Directory of Open Access Journals (Sweden)

    Vilija Grincevičienė

    2011-04-01

    Full Text Available The article describes the problem of academic dishonesty. Looking over the results of research done in foreign countries (the USA, Romania, Poland, it is possible to assert that the ethics of a scientist is a topical problem nowadays not only in Lithuania but also all over the world. The results of pilot research show that although in all curricula, textbooks and other sources it is declared that each researcher or a team must keep to certain ethics rules, not everything goes well. Respondents were first year PhD students of Vilnius Gediminas Technical University (N=51. Taking into account the results, more attention should be paid to the analysis and correction of the situation.

  18. Earth and Space Science PhD Employment Trends

    Science.gov (United States)

    Giesler, J. L.

    2001-05-01

    A recent report by the American Geophysical Union and the American Geological Institute, "Earth and Space Science PhDs, Class of 1999" looked at employment trends of recent graduates. Demographically, our graduates are, as a population, older than those who graduated in any other physical science. While almost one-third of graduates are employed in a different subfield than that of their degree, more than 80% of Earth and space science PhDs secure initial employment in the geosciences. Graduates are finding employment in less than 6 months and the unemployment rate has dropped significantly below that of two years ago. The PhD classes of 1996, 1997, and 1998 had ~ 50% of their graduates taking postdoctoral appointments. In 1999, this declined to only 38% postdocs with an increase in permanent employment in both the education and government sectors. Perception of the job market is improving as well. Respondents are considerably happier than they were in 1996.

  19. Analysis list: ph-d [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ph-d Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/p...h-d.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/ph-d.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/ph-d.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/ph-d.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/ph-d.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

  20. Learning from a Lived Experience of a PhD: A Reflexive Ethnography of Two Journeys

    Science.gov (United States)

    Aziato, Lydia

    2015-01-01

    Introduction: Nurses globally have strived to obtain a Doctor of Philosophy Degree (PhD) especially those in academia. Few publications have focused on lived experiences of nurses especially those reporting failed attempts. Thus, this paper presents how lessons learnt from a failed attempt of a PhD in Nursing was used to achieve an outstanding…

  1. Pipelines or pipe dreams? PhD production and other matters in a ...

    African Journals Online (AJOL)

    This retrospective study documents the Masters and PhD training of 131 Dental Research Institute (DRI) postgraduates (1954-2006) to establish demographics, throughput and research outcomes for future PhD pipeline strategies using the DRI database. Descriptive statistics show four degree-based groups of ...

  2. A networked pathway to the PhD: The African-Norwegian case of ...

    African Journals Online (AJOL)

    How do PhD students become socialised into the professional world of academic work? This article pays attention to a 'networked' support pathway towards a PhD. The network constitutes an international research collaboration through a programme called Productive Learning Cultures (PLC) (2002-2011) between Norway ...

  3. Searching for "A Third Space": A Creative Pathway towards International PhD Students' Academic Acculturation

    Science.gov (United States)

    Elliot, Dely Lazarte; Baumfield, Vivienne; Reid, Kate

    2016-01-01

    Undertaking a PhD is a challenging endeavour. Pursuing a doctoral education in a "foreign" context tends to increase the demands of this intellectual venture. The nature of research-based PhD programmes, often characterised by a lack of formal curricula where academic supervision lasts several years, may add another layer of complexity.…

  4. A model perception on the independence of PhD students in ...

    African Journals Online (AJOL)

    Amy Stambach

    A model perception on the independence of PhD students in promoting the ... At school of postgraduate studies, all academic documents related to PhD ..... Workshop series sponsored by the counseling center at the University of Illinois in ...

  5. A fast ellipse extended target PHD filter using box-particle implementation

    Science.gov (United States)

    Zhang, Yongquan; Ji, Hongbing; Hu, Qi

    2018-01-01

    This paper presents a box-particle implementation of the ellipse extended target probability hypothesis density (ET-PHD) filter, called the ellipse extended target box particle PHD (EET-BP-PHD) filter, where the extended targets are described as a Poisson model developed by Gilholm et al. and the term "box" is here equivalent to the term "interval" used in interval analysis. The proposed EET-BP-PHD filter is capable of dynamically tracking multiple ellipse extended targets and estimating the target states and the number of targets, in the presence of clutter measurements, false alarms and missed detections. To derive the PHD recursion of the EET-BP-PHD filter, a suitable measurement likelihood is defined for a given partitioning cell, and the main implementation steps are presented along with the necessary box approximations and manipulations. The limitations and capabilities of the proposed EET-BP-PHD filter are illustrated by simulation examples. The simulation results show that a box-particle implementation of the ET-PHD filter can avoid the high number of particles and reduce computational burden, compared to a particle implementation of that for extended target tracking.

  6. Self-sealing barriers of sand/bentonite-mixtures in a clay repository. SB-experiment in the Mont Terri Rock Laboratory. Final report

    International Nuclear Information System (INIS)

    Rothfuchs, Tilmann; Czaikowski, Oliver; Hartwig, Lothar; Hellwald, Karsten; Komischke, Michael; Miehe, Ruediger; Zhang, Chun-Liang

    2012-10-01

    Several years ago, GRS performed laboratory investigations on the suitability of clay/mineral mixtures as optimized sealing materials in underground repositories for radioactive wastes /JOC 00/ /MIE 03/. The investigations yielded promising results so that plans were developed for testing the sealing properties of those materials under representative in-situ conditions in the Mont Terri Rock Laboratory (MTRL). The project was proposed to the ''Projekttraeger Wassertechnologie und Entsorgung (PtWT+E)'', and finally launched in January 2003 under the name SB-project (''Self-sealing Barriers of Clay/Mineral Mixtures in a Clay Repository''). The project was divided in two parts, a pre-project running from January 2003 until June 2004 under contract No. 02E9713 /ROT 04/ and the main project running from January 2004 until June 2012 under contract No. 02E9894 with originally PtWT+E, later renamed as PTKA-WTE. In the course of the pre-project it was decided to incorporate the SB main project as a cost shared action of PtWT+E and the European Commission (contract No. FI6W-CT-2004-508851) into the EC Integrated Project ESDRED (Engineering Studies and Demonstrations of Repository Designs) performed by 11 European project partners within the 6th European framework programme. The ESDRED project was terminated prior to the termination of the SB project. Interim results were reported by mid 2009 in two ESDRED reports /DEB09/ /SEI 09/. This report presents the results achieved in the whole SB-project comprising preceding laboratory investigations for the final selection of suited material mixtures, the conduction of mock-up tests in the geotechnical laboratory of GRS in Braunschweig and the execution of in-situ experiments at the MTRL.

  7. Impact of the electron donor on in situ microbial nitrate reduction in Opalinus Clay: results from the Mont Terri rock laboratory (Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Bleyen, N.; Smets, S. [Belgian Nuclear Research Centre SCK-CEN, Mol (Belgium); Small, J. [National Nuclear Laboratory NLL, Warrington (United Kingdom); and others

    2017-04-15

    At the Mont Terri rock laboratory (Switzerland), an in situ experiment is being carried out to examine the fate of nitrate leaching from nitrate-containing bituminized radioactive waste, in a clay host rock for geological disposal. Such a release of nitrate may cause a geochemical perturbation of the clay, possibly affecting some of the favorable characteristics of the host rock. In this in situ experiment, combined transport and reactivity of nitrate is studied inside anoxic and water-saturated chambers in a borehole in the Opalinus Clay. Continuous circulation of the solution from the borehole to the surface equipment allows a regular sampling and online monitoring of its chemical composition. In this paper, in situ microbial nitrate reduction in the Opalinus Clay is discussed, in the presence or absence of additional electron donors relevant for the disposal concept and likely to be released from nitrate-containing bituminized radioactive waste: acetate (simulating bitumen degradation products) and H{sub 2} (originating from radiolysis and corrosion in the repository). The results of these tests indicate that - in case microorganisms would be active in the repository or the surrounding clay - microbial nitrate reduction can occur using electron donors naturally present in the clay (e.g. pyrite, dissolved organic matter). Nevertheless, non-reactive transport of nitrate in the clay is expected to be the main process. In contrast, when easily oxidizable electron donors would be available (e.g. acetate and H{sub 2}), the microbial activity will be strongly stimulated. Both in the presence of H{sub 2} and acetate, nitrite and nitrogenous gases are predominantly produced, although some ammonium can also be formed when H{sub 2} is present. The reduction of nitrate in the clay could have an impact on the redox conditions in the pore-water and might also lead to a gas-related perturbation of the host rock, depending on the electron donor used during denitrification

  8. Deformation mechanisms and evolution of the microstructure of gouge in the Main Fault in Opalinus Clay in the Mont Terri rock laboratory (CH)

    Science.gov (United States)

    Laurich, Ben; Urai, Janos L.; Vollmer, Christian; Nussbaum, Christophe

    2018-01-01

    We studied gouge from an upper-crustal, low-offset reverse fault in slightly overconsolidated claystone in the Mont Terri rock laboratory (Switzerland). The laboratory is designed to evaluate the suitability of the Opalinus Clay formation (OPA) to host a repository for radioactive waste. The gouge occurs in thin bands and lenses in the fault zone; it is darker in color and less fissile than the surrounding rock. It shows a matrix-based, P-foliated microfabric bordered and truncated by micrometer-thin shear zones consisting of aligned clay grains, as shown with broad-ion-beam scanning electron microscopy (BIB-SEM) and optical microscopy. Selected area electron diffraction based on transmission electron microscopy (TEM) shows evidence for randomly oriented nanometer-sized clay particles in the gouge matrix, surrounding larger elongated phyllosilicates with a strict P foliation. For the first time for the OPA, we report the occurrence of amorphous SiO2 grains within the gouge. Gouge has lower SEM-visible porosity and almost no calcite grains compared to the undeformed OPA. We present two hypotheses to explain the origin of gouge in the Main Fault: (i) authigenic generation consisting of fluid-mediated removal of calcite from the deforming OPA during shearing and (ii) clay smear consisting of mechanical smearing of calcite-poor (yet to be identified) source layers into the fault zone. Based on our data we prefer the first or a combination of both, but more work is needed to resolve this. Microstructures indicate a range of deformation mechanisms including solution-precipitation processes and a gouge that is weaker than the OPA because of the lower fraction of hard grains. For gouge, we infer a more rate-dependent frictional rheology than suggested from laboratory experiments on the undeformed OPA.

  9. NASA Graduate Student Researchers Program Ronald E. McNair PhD Program

    Science.gov (United States)

    Howard, Sunnie

    1998-01-01

    The NASA Ronald E. McNair PHD Program was funded in September 1995. Implementation began during the spring of 1996. The deferment of the actual program initial semester enabled the program to continue support through the fall semester of 1998. This was accomplished by a no-cost extension from August 15, 1998 through December 31, 1998. There were 12 fellows supported by the program in 1996, 15 fellows in 1997, and 15 fellows 1998. Current program capacity is 15 fellows per funding support. Support for the academic outreach component began in spring 1998. The program was named the "Good Enough" Crew Activity (GECA) in honor of Dr. McNair's philosophy of everyone being good enough to achieve anything they want bad enough. The program currently enrolls 65 students from the third through the eight grades. The program is held 12 Saturdays per semester. The time is 9:00 AM to 12:30 PM each Saturday Morning. Program direction and facilitation is jointly administered with the PHD fellows and the Saturday Academy staff. Dr. John Kelly, REM-PHD Principal Investigator serves in a program oversight and leadership capacity. Ms. Sunnie Howard, The NASA REM-PHD Administrative Coordinator serves in an administrative and logistical capacity. Mr. Aaron Hatch, the NASA-AMES Liaison Officer, serve@'in a consultative and curriculum review capacity. The first recognition activity will be held on December 12, 1998, with the students, parents, faculty, PHD fellows, and other local student support services persons. Program outreach efforts are jointly supported by the NASA REM-PHD Program and the National Space Grant College and Fellowship Program. The Ph.D. program reached its first milestone in May 1998. North Carolina A&T State University graduated the first Ph.D. fellows. The first three Ph.D. Alumni were Ronald E. McNair PHD Program Fellows. It is hoped that this is just the beginning of a highly acclaimed doctoral program. The ultimate program success will be recognized when the

  10. Qualitative methods in PhD theses from general practice in Scandinavia.

    Science.gov (United States)

    Malterud, Kirsti; Hamberg, Katarina; Reventlow, Susanne

    2017-12-01

    Qualitative methodology is gaining increasing attention and esteem in medical research, with general practice research taking a lead. With these methods, human and social interaction and meaning can be explored and shared by systematic interpretation of text from talk, observation or video. Qualitative studies are often included in Ph.D. theses from general practice in Scandinavia. Still, the Ph.D. programs across nations and institutions offer only limited training in qualitative methods. In this opinion article, we draw upon our observations and experiences, unpacking and reflecting upon values and challenges at stake when qualitative studies are included in Ph.D. theses. Hypotheses to explain these observations are presented, followed by suggestions for standards of evaluation and improvement of Ph.D. programs. The authors conclude that multimethod Ph.D. theses should be encouraged in general practice research, in order to offer future researchers an appropriate toolbox.

  11. MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing

    DEFF Research Database (Denmark)

    2014-01-01

    MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing......MATLAB simulation software used for the PhD thesis "Acquisition of Multi-Band Signals via Compressed Sensing...

  12. Integrative research on environmental and landscape change: PhD students' motivations and challenges.

    Science.gov (United States)

    Tress, Bärbel; Tress, Gunther; Fry, Gary

    2009-07-01

    The growing demand for integrative (interdisciplinary or transdisciplinary) approaches in the field of environmental and landscape change has increased the number of PhD students working in this area. Yet, the motivations to join integrative projects and the challenges for PhD students have so far not been investigated. The aims of this paper were to identify the understanding of PhD students with regard to integrative research, their motivations to join integrative projects, their expectations in terms of integration and results, and to reveal the challenges they face in integrative projects. We collected data by a questionnaire survey of 104 PhD students attending five PhD Master Classes held from 2003 to 2006. We used manual content analysis to analyse the free-text answers. The results revealed that students lack a differentiated understanding of integrative approaches. The main motivations to join integrative projects were the dissertation subject, the practical relevance of the project, the intellectual stimulation of working with different disciplines, and the belief that integrative research is more innovative. Expectations in terms of integration were high. Core challenges for integration included intellectual and external challenges such as lack of knowledge of other disciplines, knowledge transfer, reaching depth, supervision, lack of exchange with other students and time demands. To improve the situation for PhD students, we suggest improving knowledge on integrative approaches, balancing practical applicability with theoretical advancement, providing formal introductions to other fields of research, and enhancing institutional support for integrative PhD projects.

  13. Al menos, un poco de aire fresco. Contribución a una relectura de la paz y la libertad religiosa desde la encíclica Pacem in terris

    Directory of Open Access Journals (Sweden)

    Alberto Echeverri

    2014-09-01

    Full Text Available In the fiftieth anniversary of the publication of the Pacem in terris of John XXIII, contemporary to the beginning of the II Vatican Council, the text makes emphasis on the interrelationship between peace and religious liberty as a result of the opening allowed by the encyclical that was determinant to overcome the tolerance attitude in religious issues that was promoted by the Roman Catholic Church in the last century. The conciliation assembly highlights the contributions made by two specific documents: the Religious Liberty Decree and the Declaration regarding Non-Christian Religions. The assembly also suggests some lines to reflect about religious liberty in a discussion among diverse religious organizations.

  14. Reply to: Terry, J. and Goff, J. comment on “Late Cenozoic sea level and the rise of modern rimmed atolls” by Toomey et al. (2016), Palaeogeography, Palaeoclimatology, Palaeoecology 4 51: 73–83.

    Science.gov (United States)

    Toomey, Michael; Ashton, Andrew; Raymo, Maureen E.; Perron, J. Taylor

    2017-01-01

    We appreciate Terry and Goff's thoughtful comment in response to our proposed atoll development model. Flank collapse of reef-built slopes likely does affect plan-form atoll morphology in some locations and potentially poses a tsunami hazard to low-lying Pacific islands (Terry and Goff, 2013). However, given the often rapid rates of lagoon infill (> 1 mm/yr; Montaggioni, 2005), such failure events would likely need to be frequent and widespread in order to leave a morphologic imprint on modern western Pacific atoll lagoon depths. Few atoll flank collapse features have been dated but many of the arcuate bight-like structures (ABLS) identified could be inherited from scars incised into the initial volcanic edifice (e.g. Terry and Goff, 2013 and refs. therein) — submarine mass wasting has been extensively documented on young hotspot islands (e.g. Hawaiian Islands: Moore et al., 1989; Reunion: Oehler et al., 2008). Atolls in the Marshall Islands, where our main study site Enewetak Atoll is located, are likely ~ 50–100 million years old (Larson et al., 1995) and dating of adjacent deep-water turbidite aprons in the Nauru Basin (DSDP Site 462; Schlanger and Silva, 1986) suggests that large atoll flank collapse events have been relatively infrequent there since the mid-Miocene (wasting events, will be essential for exploring the plan-form and 3D shapes of atolls. To our knowledge, no quantitative model of long-term atoll development has explicitly linked lagoon restriction/sedimentation to episodic flank collapse events (e.g. Montaggioni et al., 2015; Paterson et al., 2006; Quinn, 1991; Warrlich et al., 2002). Testing Terry and Goff's proposed conceptual model for how rim failure processes affect atoll morphology in a numerical context will require deep drilling along arcuate bight-like structures, as well as adjacent, unaffected, rim and lagoon areas, in order quantify how often failures occur and how quickly the rim/lagoon is rebuilt afterwards. The model we present

  15. Strategy formulation for the Phd Health Market (Pty) Ltd franchise group / Henk Heath

    OpenAIRE

    Heath, Henk

    2007-01-01

    Phd Health Market (Pty) Ltd was born from the vision of Anton Dupper and Advocate Jan Grobler, to turn a health store in Welkom, South Africa, into a national health franchise in the health & fitness industry. Phd Health Market has a vision to radically change society as a whole by changing nutritional eating and instilling a healthy lifestyle as a whole, which could be easily adapted by all. Phd Health Market is a small developing franchise group, requiring a much needed strategic plan in or...

  16. Doc of prophage P1 is inhibited by its antitoxin partner Phd through fold complementation

    DEFF Research Database (Denmark)

    Garcia-Pino, Abel; Christensen-Dalsgaard, Mikkel; Wyns, Lode

    2008-01-01

    Prokaryotic toxin-antitoxin modules are involved in major physiological events set in motion under stress conditions. The toxin Doc (death on curing) from the phd/doc module on phage P1 hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation....... This Phd domain is intrinsically disordered in solution and folds into an alpha-helix upon binding to Doc. The details of the interactions reveal the molecular basis for the inhibitory action of the antitoxin. The complex resembles the Fic (filamentation induced by cAMP) proteins and suggests a possible......-antitoxin locus for its action in vivo....

  17. Physico-chemical characterisation and sorption measurements of Cs, Sr, Ni, Eu, Th, Sn and Se on Opalinus clay from Mont Terri

    International Nuclear Information System (INIS)

    Lauber, Matthias; Baeyens, Bart; Bradbury, Michael H.

    2000-12-01

    Opalinus Clay is currently under investigation as a potential host rock for the disposal of high level and long-lived intermediate radioactive waste. A throughout physico-chemical characterisation was carried out on a bore core sample from the underground rock laboratory Mont Terri (Canton Jura). The results of these investigations indicate that the major characteristics (mineralogy, cation exchange capacity, cation occupancies, selectivity coefficients, chloride and sulphate inventories) were very similar to a different core sample, previously used for pore water modelling studies. It was concluded that the pore water compositions derived in the earlier studies were reliable and could be used in this work. The organic matter which dissolved from the Opalinus Clay rock was not humic or fulvic acids and the concentration remaining in the liquid phase in the sorption experiments was < 0.5 ppm C. The organic matter is therefore considered to have little or no influence on the sorption behaviour of the studied radionuclides. Redox potential measurements of the Opalinus Clay/synthetic pore water system inside the glove boxes indicated anoxic conditions. The main focus of the experimental work presented here is on the sorption behaviour of Cs (I), Sr (II), Ni (II), Eu (III), Th (IV), Sn (IV) and Se (IV) on Opalinus Clay equilibrated with synthetic pore waters at pH 6.3 and 8. Sorption isotherms were measured for Cs, Ni, Eu, Th and Se. Single point data were measured for Sr and Sn. For all radionuclides studied the sorption kinetics were measured first. The times required to complete the sorption on the Opalinus Clay varied between one day for Th and one month for Ni and Se. Within the concentration ranges under study the uptake of Cs, Ni, Eu and Se on Opalinus Clay was non-linear, whereas for Th a linear sorption behaviour was observed. For Ni, Eu and Th the sorption increased with increasing pH. For Cs a pH independent sorption behaviour was observed. The concentration

  18. Pore-water evolution and solute-transport mechanisms in Opalinus Clay at Mont Terri and Mont Russelin (Canton Jura, Switzerland)

    Energy Technology Data Exchange (ETDEWEB)

    Mazurek, M. [Institute of Geological Sciences, University of Berne, Berne (Switzerland); Haller de, A. [Earth and Environmental Sciences, University of Geneva, Geneva (Switzerland)

    2017-04-15

    Data pertinent to pore-water composition in Opalinus Clay in the Mont Terri and Mont Russelin anticlines have been collected over the last 20 years from long-term in situ pore-water sampling in dedicated boreholes, from laboratory analyses on drill cores and from the geochemical characteristics of vein infills. Together with independent knowledge on regional geology, an attempt is made here to constrain the geochemical evolution of the pore-waters. Following basin inversion and the establishment of continental conditions in the late Cretaceous, the Malm limestones acted as a fresh-water upper boundary leading to progressive out-diffusion of salinity from the originally marine pore-waters of the Jurassic low-permeability sequence. Model calculations suggest that at the end of the Palaeogene, pore-water salinity in Opalinus Clay was about half the original value. In the Chattian/Aquitanian, partial evaporation of sea-water occurred. It is postulated that brines diffused into the underlying sequence over a period of several Myr, resulting in an increase of salinity in Opalinus Clay to levels observed today. This hypothesis is further supported by the isotopic signatures of SO{sub 4}{sup 2-} and {sup 87}Sr/{sup 86}Sr in current pore-waters. These are not simple binary mixtures of sea and meteoric water, but their Cl{sup -} and stable water-isotope signatures can be potentially explained by a component of partially evaporated sea-water. After the re-establishment of fresh-water conditions on the surface and the formation of the Jura Fold and Thrust Belt, erosion caused the activation of aquifers embedding the low-permeability sequence, leading to the curved profiles of various pore-water tracers that are observed today. Fluid flow triggered by deformation events during thrusting and folding of the anticlines occurred and is documented by infrequent vein infills in major fault structures. However, this flow was spatially focussed and of limited duration and so did not

  19. Simulation with Phast of the pore water chemistry experiment results (Mont Terri Url, Switzerland), including transport, thermodynamics, kinetics, and biological activity

    International Nuclear Information System (INIS)

    Tournassat, C.; Gaucher, E.; Pearson, F.J.; Mettler, S.; Wersin, P.

    2005-01-01

    Full text of publication follows: The Pore water Chemistry (PC-)experiment was initially designed to determine the processes that control the redox properties of pore water in the Opalinus Clay at the Mont Terri URL. However, changes in isotopic data and chemical parameters such as pH, alkalinity, dissolved methane, acetate and sulphate concentrations indicated unexpected microbial activity. The origin of the bacteria is not clear. In the light of published data, an indigenous origin cannot be ruled out. A combined biological and reactive transport model has been developed with the parallel PHAST software to simulate the processes that determine pore water chemistry. The influence of bacterial activity on the system is successfully modelled by considering different reaction pathways scenarios including aceto-genesis, methano-genesis, and methane/acetate oxidation coupled to sulphate reduction. Several conclusions can be clearly stated in the light of the simulation results: - The measured redox potentials (redox electrode) are in line with the S(-II)/S(+VI) redox system. - In the undisturbed pore water, S(-II) and S(+VI) activities are controlled by a mineral assemblage containing pyrite and a Fe carbonate (siderite or ankerite). pH is buffered by mineral phases and SO 4 2- concentration is inherited from the marine sedimentary rock. - Some local redox potentials in the sedimentary rock do not correspond to the measured redox potential; for instance, organic matter/HCO 3 - and CH 4 /HCO 3 - systems are not at equilibrium with the measured redox potential. - Redox disequilibrium can be exploited by micro-organisms as a source of energy for their metabolism. In this experiment CH 4 , acetate and other organic acids were produced and SO 4 2- was reduced to HS - . The redox properties of the system are then governed by kinetics rather than by thermodynamic equilibrium. The unexpected persistence of acetate in the borehole water is one of the consequences of these

  20. Development of a tomographic method using cosmic ray muons: application to the Mont Terri underground laboratory and la Soufriere de Guadeloupe

    International Nuclear Information System (INIS)

    Lesparre, N.

    2011-01-01

    Cosmic muons are produced in cascade processes following the interactions of cosmic rays with the atmosphere. Muons are fundamental particles with a mass 200 times higher than electrons. Their low interaction probability with matter allows them to cross the atmosphere and even the first kilometers of the Earth crust. The muons flux is attenuated through a media as function of the quantity of matter crossed. The study of the muon flux attenuation allows then to obtain a direct measurement of the rock opacity. This opacity corresponds to the media density, integrated along the muon path through rock. Muons' trajectory is indeed considered to be straight when crossing rock. It is then possible to realise geophysical tomographies by setting a sensor network around geological objects in order to determine the internal structures geometry inside these objects. An underground muon flux model is developed herein from flux models estimated at surface and a model of muon flux attenuation through rock. A feasibility equation of the muon tomography is then established in order to determine the minimum time of data acquisition to distinguish heterogeneities. Four muons telescopes have been built during this thesis and conditioned to bear field installation, notably in tropical media. These telescopes are made by two or three matrices of detection constituted of scintillating bars linked to photomultipliers. The modeling of the telescopes detection capacity and angular resolution is realised as function of their geometrical configuration. A calibration method is also established in order to correct the signal from any distortion. Moreover, arrangements to reduce the backward noise produced by low energy particles are set up and evaluated. The development of this new tomographic method is then illustrated by two geophysical applications. The measurements realised in the Mont Terri underground laboratory (Switzerland) allowed us to benefit from stable acquisition conditions to

  1. Personal profile: interview with Bill Andrews, Ph.D.

    Science.gov (United States)

    Andrews, Bill

    2011-08-01

    Dr. William H. Andrews has worked in the biotech industry for 31 years, focusing the last 19 years on finding ways to extend human life span through the intervention of telomere shortening in human cells. Dr. Andrews earned his Ph.D. in Molecular and Population Genetics at the University of Georgia. He was a Senior Scientist at Armos Corporation and Codon Corporation, Director of Molecular Biology at Codon and at Geron Corporation, and Director of Technology Development at EOS Biosciences. He is presently the founder, President, and CEO of Sierra Sciences, a biotechnology company focused exclusively on finding drugs that will transiently induce the expression of endogenous telomerase in human cells. Sierra Sciences has already identified more than 30 such drugs and is presently characterizing their mechanism of action. While Director of Molecular Biology at Geron Corporation, Dr. Andrews was one of the principal discoverers of both the RNA and protein components of human telomerase and was awarded second place as "National Inventor of the Year" in 1997 for this work. He is presently a named inventor on 43 U.S- issued telomerase patents.

  2. The Intrinsically Disordered Domain of the Antitoxin Phd Chaperones the Toxin Doc against Irreversible Inactivation and Misfolding*

    Science.gov (United States)

    De Gieter, Steven; Konijnenberg, Albert; Talavera, Ariel; Butterer, Annika; Haesaerts, Sarah; De Greve, Henri; Sobott, Frank; Loris, Remy; Garcia-Pino, Abel

    2014-01-01

    The toxin Doc from the phd/doc toxin-antitoxin module targets the cellular translation machinery and is inhibited by its antitoxin partner Phd. Here we show that Phd also functions as a chaperone, keeping Doc in an active, correctly folded conformation. In the absence of Phd, Doc exists in a relatively expanded state that is prone to dimerization through domain swapping with its active site loop acting as hinge region. The domain-swapped dimer is not capable of arresting protein synthesis in vitro, whereas the Doc monomer is. Upon binding to Phd, Doc becomes more compact and is secured in its monomeric state with a neutralized active site. PMID:25326388

  3. UK to train 100 PhD students in data science

    Science.gov (United States)

    Allen, Michael

    2017-12-01

    A new PhD programme to develop techniques to handle the vast amounts of data being generated by experiments and facilities has been launched by the UK's Science and Technology Facilities Council (STFC).

  4. Trends in landscape research and landscape planning : implications for PhD students

    NARCIS (Netherlands)

    Tress, G.; Tress, B.; Fry, G.; Antrop, M.

    2005-01-01

    This chapter introduces the contents of the book through an analysis of current trends in landscape research and landscape planning and a discussion of the consequences of these trends for PhD students.

  5. WHAT ARE AGRICULTURAL ECONOMICS PH.D. STUDENTS LEARNING ABOUT AGRIBUSINESS RESEARCH METHODS AND SUBJECT AREAS?

    OpenAIRE

    House, Lisa; Sterns, James A.

    2002-01-01

    This document contains the PowerPoint presentation given by the authors at the 2002 WCC-72 meetings, regarding what agricultural economics Ph.D students are learning about agribusiness research methods and subject areas.

  6. Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students

    OpenAIRE

    Tesh, Vernon L.

    2016-01-01

    With the goal of promoting the development of early career investigators in the field of toxinology, Toxins welcomed applications for the 2016 Toxins Travel Awards for post-doctoral fellows and Ph.D. students. [...

  7. Announcing the 2016 Toxins Travel Awards for Post-Doctoral Fellows and Ph.D. Students

    Directory of Open Access Journals (Sweden)

    Vernon L. Tesh

    2016-02-01

    Full Text Available With the goal of promoting the development of early career investigators in the field of toxinology, Toxins welcomed applications for the 2016 Toxins Travel Awards for post-doctoral fellows and Ph.D. students. [...

  8. Actualization of the PhD Students' Intercultural Research Competencies in Global Society

    Directory of Open Access Journals (Sweden)

    Inga Dailidiene

    2013-12-01

    Full Text Available globalization is changing the qualitative characteristics of society, affecting both the life and mentality of people. In relevance to globalization, higher education is gaining new dimensions as well. Bologna and Lisbon documents guide and obligate each country to create integrated and harmonious international space of higher education in Europe. phd studies are considered as integral in the higher education structure; therefore, internationalization is a significant imperative for phd studies development. In the process of internationalization, the need for students’ intercultural competencies is widely recognized. Firstly, we suppose that the impact of globalization on internationalization still remains underestimated. Globalization makes internationalization not only more intense, but also qualitatively different. Secondly, there is a lack of systemic analysis on the development of intercultural research competencies in phd studies. We relate the need for intercultural research competencies to the following critical and rhetorical question: ‘Are today’s phd students ready to solve tomorrow’s global problems?’

  9. Ph.D. Post-Doctoral Training Program in Breast Cancer Research

    National Research Council Canada - National Science Library

    Edwards, Dean

    2002-01-01

    .... The curriculum of the Breast Cancer Training Program extends beyond that of the normal Ph.D. requirements to include didactic classroom teaching, journal clubs, seminars, workshops and mini-symposiums on relevant topics in breast cancer...

  10. Ph.D. Post-Doctoral Training Program in Breast Cancer Research

    National Research Council Canada - National Science Library

    Edwards, Dean

    2001-01-01

    .... The curriculum of the Breast Cancer Training Program extends beyond that of the normal Ph.D. requirements to include didactic classroom teaching, journal clubs, seminars, workshops and mini-symposiums on relevant topics in breast cancer...

  11. Ph.D. Post-Doctoral Training Program in Breast Cancer Research

    National Research Council Canada - National Science Library

    Edwards, Dean

    2004-01-01

    .... The curriculum of the Breast Cancer Training Program extends beyond that of the normal Ph.D. requirements to include didactic classroom teaching, journal clubs, seminars, workshops and mini-symposiums on relevant topics in breast cancer...

  12. CPT Special Report: Survey of Ph.D. Programs in Chemistry.

    Science.gov (United States)

    Journal of Chemical Education, 1997

    1997-01-01

    Presents preliminary results from a survey taken by the American Chemical Society (ACS) Committee on Professional Training (CPT) to determine the current practices among 155 Ph.D. programs in chemistry. (DKM)

  13. Articulating Expectations for PhD Candidature upon Commencement: Ensuring Supervisor/Student "Best Fit"

    Science.gov (United States)

    Moxham, Lorna; Dwyer, Trudy; Reid-Searl, Kerry

    2013-01-01

    The journey towards completion of a PhD is a bumpy one for many. One of the major factors that influence successful and on-time thesis completion is the relationship that the PhD candidate has with her or his supervisor. This paper presents results from research undertaken using a 12-item survey to collect data from a purposive sample: PhD…

  14. Social Policy in Social Work PhD Programs in the United States

    Science.gov (United States)

    Lightfoot, Elizabeth; Gal, John; Weiss-Gal, Idit

    2018-01-01

    While there has been a long-standing concern about the role of policy within social work education and social work practice, most of the emphasis has been on social work education at the BSW and MSW levels. This article examines policy education at the PhD level. It first explores how policy is taught in social work PhD programs in the United…

  15. MS PHD'S: Effective Strategies for the Retention and Advancement of URM Students in ESS

    Science.gov (United States)

    Escalera, J.; Burgess, A. K.; Pace, L.; Scott, O.; Strickland, J.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.

    2012-12-01

    The Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) Professional Development Program in Earth system science (ESS) is a model initiative for improving the retention of underrepresented minority (URM) students in STEM fields. Entering its ninth cohort, MS PHD'S remains committed to helping URM undergraduate and graduate students achieve outstanding careers in ESS. MS PHD'S facilitates URM student achievement through a three-phase program designed to increase student exposure to the ESS community. By engaging in a series of professional development and skill building exercises, peer-to-peer community building activities, participation in scientific society conferences and workshops, mentoring by URM and other scientists, and a virtual community, URM students gain the confidence and support necessary to achieve their academic goals and enter the ESS workforce. Since its inception, MS PHD'S continues to support 189 participants. Of these 189 participants, 35 have advanced from undergraduate and graduate academic pathways to completion of their PhD and another 60 are currently enrolled in doctoral programs. MS PHD'S maintains close ties with program alumni to further support retention, inclusivity, and broadening participation of URM students and graduates in STEM activities. Its model is built on reengaging alumni to become mentors and leaders for each new cohort as well as facilitating valuable opportunities for alumni to advance in their ESS related academic and professional career pathways.

  16. Skill development in collaborative research projects: A comparison between PhD students in multi-actor research programs and in traditional trajectories

    NARCIS (Netherlands)

    Wardenaar, T.; Belder, R.; de Goede, M.E.E; Horlings, E.; van den Besselaar, P.

    2014-01-01

    The growing number of PhD students has spurred debates about the societal relevance of PhD training trajectories. The academic labour market does not provide enough jobs and many PhD graduates will have a career outside academia. It has been questioned whether current PhD training trajectories are

  17. Preparing for Graduate-Level Training in Professional Psychology: Comparisons across Clinical PhD, Counseling PhD, and Clinical PsyD Programs

    Science.gov (United States)

    Karazsia, Bryan T.; Smith, Lena

    2016-01-01

    In the present study, faculty who teach in clinical and counseling doctor of philosophy (PhD) or doctor of psychology (PsyD) programs completed surveys regarding preferences for prospective student preparations to graduate programs. Faculty expectations of minimum and ideal undergraduate training were highest for scientific methods, though…

  18. Oral biology in middle age: a history of the University at Buffalo Oral Biology PhD Program.

    Science.gov (United States)

    Scannapieco, F A

    2014-05-01

    In 1960, the first Department of Oral Biology in the United States dedicated to the conduct of research, graduate biomedical research education, and the provision of basic oral science education for the DDS curriculum was established at the University at Buffalo. In 1963, the Department organized the first PhD Program in Oral Biology in the United States. This PhD program has produced a large cadre of oral health researchers, many of whom have gone on to make major contributions to dental research and education. This article provides a brief history of the program, the context within which the program was organized and developed, and a description of some of the many faculty, students, and fellows associated with the program. Additionally, to celebrate the 50th anniversary of this program, a symposium, entitled "The Oral Microbiome, Immunity and Chronic Disease", was held on June 12-14, 2013, in Buffalo, New York. The proceedings are published online in Advances in Dental Research (2014, Vol. 26).

  19. Geophysical monitoring of the EDZ during a gallery excavation in the Opalinus clay of the Mont Terri URL: design and principles of specific in situ experimental setups

    International Nuclear Information System (INIS)

    Gibert, D.; Maineult, A.; Kergosien, B.; Le Gonidec, Y.; Nicollin, F.; Sarout, J.; Wassermann, J.

    2012-01-01

    Document available in extended abstract form only. At the Mont Terri Underground Rock Laboratory, the gallery Ga08 was excavated in August 2008 to join the end-face of the pre-existing gallery Ga04. The Excavation Damaged Zone (EDZ) induced during the gallery construction was monitored from the instrumented face of Ga04. The EZ-G08 experiments required original acquisition setups, specifically designed to be installed in small boreholes and to ensure long term measurements. Different geophysical methods have been experimented for the EZ-G08 project and specific design of the experiments were required in order to coordinate multiple and simultaneous acquisitions, including acoustic emission (AE) acquisition setup (16 acoustic receivers), manufacturing of a combined electrical (256 electrodes) and acoustic tomography setup (64 receivers) to be introduced in horizontal boreholes with small diameters (56 mm), design of an acoustic source, design and manufacturing of a combined electrical tomography (64 lead electrodes) and self-potential measurements (64 un-polarizable electrodes). Other arrays of electrodes have also been placed at the end-face of Ga04 (715 inox electrodes and an array of 16 un-polarizable electrodes). The self-potential (SP) monitoring took place in the borehole BEZ-G5 equipped in mid- February 2008 with a specific device on which custom-made electrodes were fixed. To avoid polarisation effect and guaranty a satisfactorily signal-to-noise ratio, SP was measured with 64 un-polarizable electrodes, with an offset of 15 cm made of a metallic wire in chemical equilibrium with a surrounding solution containing a salt of the same metal. The electrical contact between the solution and the natural medium is ensured by a porous material. The electrodes were mounted upward on a half-cylinder fixed onto an inflatable pipe and introduced in BEZ-G5. The internal pipe was inflated to ensure a good electrical contact between the electrodes and the borehole wall. The

  20. Monitoring and modelling of thermo-hydro-mechanical processes - main results of a heater experiment at the Mont Terri underground rock laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Ingeborg, G.; Alheid, H.J. [BGR - Federal Institute for Geosciences and Natural Resources, Hannover (Germany); Jockwerz, N. [Gesellschaft fur Anlagen- und Reaktorsicherheit (GRS) - Final Repository Research Division, Braunschweig (Germany); Mayor, J.C. [ENRESA - Empresa Nacional des Residuos Radioactivos, Madrid (Spain); Garcia-Siner, J.L. [AITEMIN -Asociacion para la Investigacion y Desarrollo Industrial de los Recursos Naturales, Madrid, (Spain); Alonso, E. [CIMNE - Centre Internacional de Metodos Numerics en Ingenyeria, UPC, Barcelona (Spain); Weber, H.P. [NAGRA - National Cooperative for the Disposal of Radioactive Waste, Wettingen (Switzerland); Plotze, M. [ETHZ - Swiss Federal Institute of Technology Zurich, IGT, Zurich, (Switzerland); Klubertanz, G. [COLENCO Power Engineering Ltd., Baden (Switzerland)

    2005-07-01

    The long-term safety of permanent underground repositories relies on a combination of engineered and geological barriers, so that the interactions between the barriers in response to conditions expected in a high-level waste repository need to be identified and fully understood. Co-financed by the European Community, a heater experiment was realized on a pilot plant scale at the underground laboratory in Mont Terri, Switzerland. The experiment was accompanied by an extensive programme of continuous monitoring, experimental investigations on-site as well as in laboratories, and numerical modelling of the coupled thermo-hydro-mechanical processes. Heat-producing waste was simulated by a heater element of 10 cm diameter, held at a constant surface temperature of 100 C. The heater element (length 2 m) operated in a vertical borehole of 7 m depth at 4 to 6 m depth. It was embedded in a geotechnical barrier of pre-compacted bentonite blocks (outer diameter 30 cm) that were irrigated for 35 months before the heating phase (duration 18 months) began. The host rock is a highly consolidated stiff Jurassic clay stone (Opalinus Clay). After the heating phase, the vicinity of the heater element was explored by seismic, hydraulic, and geotechnical tests to investigate if the heating had induced changes in the Opalinus Clay. Additionally, rock mechanic specimens were tested in the laboratory. Finally, the experiment was dismantled to provide laboratory specimens of post - heating buffer and host rock material. The bentonite blocks were thoroughly wetted at the time of the dismantling. The volume increase amounted to 5 to 9% and was thus below the bentonite potential. Geo-electrical measurements showed no decrease of the water content in the vicinity of the heater during the heating phase. Decreasing energy input to the heater element over time suggests hence, that the bentonite dried leading to a decrease of its thermal conductivity. Gas release during the heating period occurred

  1. DELETION OR INHIBITION OF THE OXYGEN SENSOR PHD1 PROTECTS AGAINST ISCHEMIC STROKE VIA REPROGRAMMING OF NEURONAL METABOLISM

    Science.gov (United States)

    Quaegebeur, Annelies; Segura, Inmaculada; Schmieder, Roberta; Verdegem, Dries; Decimo, Ilaria; Bifari, Francesco; Dresselaers, Tom; Eelen, Guy; Ghosh, Debapriva; Schoors, Sandra; Janaki Raman, Sudha Rani; Cruys, Bert; Govaerts, Kristof; De Legher, Carla; Bouché, Ann; Schoonjans, Luc; Ramer, Matt S.; Hung, Gene; Bossaert, Goele; Cleveland, Don W.; Himmelreich, Uwe; Voets, Thomas; Lemmens, Robin; Bennett, C. Frank; Robberecht, Wim; De Bock, Katrien; Dewerchin, Mieke; Fendt, Sarah-Maria; Ghesquière, Bart; Carmeliet, Peter

    2016-01-01

    Summary The oxygen-sensing prolyl hydroxylase domain proteins (PHDs) regulate cellular metabolism, but their role in neuronal metabolism during stroke is unknown. Here we report that PHD1 deficiency provides neuroprotection in a murine model of permanent brain ischemia. This was not due to an increased collateral vessel network, nor to enhanced neurotrophin expression. Instead, PHD1−/− neurons were protected against oxygen-nutrient deprivation by reprogramming glucose metabolism. Indeed, PHD1−/− neurons enhanced glucose flux through the oxidative pentose phosphate pathway by diverting glucose from glycolysis. As a result, PHD1−/− neurons increased their redox buffering capacity to scavenge oxygen radicals in ischemia. Intracerebroventricular injection of PHD1-antisense oligonucleotides reduced the cerebral infarct size and neurological deficits following stroke. These data identify PHD1 as a novel regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke. PMID:26774962

  2. Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

    Science.gov (United States)

    Quaegebeur, Annelies; Segura, Inmaculada; Schmieder, Roberta; Verdegem, Dries; Decimo, Ilaria; Bifari, Francesco; Dresselaers, Tom; Eelen, Guy; Ghosh, Debapriva; Davidson, Shawn M; Schoors, Sandra; Broekaert, Dorien; Cruys, Bert; Govaerts, Kristof; De Legher, Carla; Bouché, Ann; Schoonjans, Luc; Ramer, Matt S; Hung, Gene; Bossaert, Goele; Cleveland, Don W; Himmelreich, Uwe; Voets, Thomas; Lemmens, Robin; Bennett, C Frank; Robberecht, Wim; De Bock, Katrien; Dewerchin, Mieke; Ghesquière, Bart; Fendt, Sarah-Maria; Carmeliet, Peter

    2016-02-09

    The oxygen-sensing prolyl hydroxylase domain proteins (PHDs) regulate cellular metabolism, but their role in neuronal metabolism during stroke is unknown. Here we report that PHD1 deficiency provides neuroprotection in a murine model of permanent brain ischemia. This was not due to an increased collateral vessel network. Instead, PHD1(-/-) neurons were protected against oxygen-nutrient deprivation by reprogramming glucose metabolism. Indeed, PHD1(-/-) neurons enhanced glucose flux through the oxidative pentose phosphate pathway by diverting glucose away from glycolysis. As a result, PHD1(-/-) neurons increased their redox buffering capacity to scavenge oxygen radicals in ischemia. Intracerebroventricular injection of PHD1-antisense oligonucleotides reduced the cerebral infarct size and neurological deficits following stroke. These data identify PHD1 as a regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke. Copyright © 2016 Elsevier Inc. All rights reserved.

  3. Employability of genetic counselors with a PhD in genetic counseling.

    Science.gov (United States)

    Wallace, Jody P; Myers, Melanie F; Huether, Carl A; Bedard, Angela C; Warren, Nancy Steinberg

    2008-06-01

    The development of a PhD in genetic counseling has been discussed for more than 20 years, yet the perspectives of employers have not been assessed. The goal of this qualitative study was to gain an understanding of the employability of genetic counselors with a PhD in genetic counseling by conducting interviews with United States employers of genetic counselors. Study participants were categorized according to one of the following practice areas: academic, clinical, government, industry, laboratory, or research. All participants were responsible for hiring genetic counselors in their institutions. Of the 30 employers interviewed, 23 envisioned opportunities for individuals with a PhD degree in genetic counseling, particularly in academic and research settings. Performing research and having the ability to be a principal investigator on a grant was the primary role envisioned for these individuals by 22/30 participants. Employers expect individuals with a PhD in genetic counseling to perform different roles than MS genetic counselors with a master's degree. This study suggests there is an employment niche for individuals who have a PhD in genetic counseling that complements, and does not compete with, master's prepared genetic counselors.

  4. Interoperability in digital electrocardiography: harmonization of ISO/IEEE x73-PHD and SCP-ECG.

    Science.gov (United States)

    Trigo, Jesús D; Chiarugi, Franco; Alesanco, Alvaro; Martínez-Espronceda, Miguel; Serrano, Luis; Chronaki, Catherine E; Escayola, Javier; Martínez, Ignacio; García, José

    2010-11-01

    The ISO/IEEE 11073 (x73) family of standards is a reference frame for medical device interoperability. A draft for an ECG device specialization (ISO/IEEE 11073-10406-d02) has already been presented to the Personal Health Device (PHD) Working Group, and the Standard Communications Protocol for Computer-Assisted ElectroCardioGraphy (SCP-ECG) Standard for short-term diagnostic ECGs (EN1064:2005+A1:2007) has recently been approved as part of the x73 family (ISO 11073-91064:2009). These factors suggest the coordinated use of these two standards in foreseeable telecardiology environments, and hence the need to harmonize them. Such harmonization is the subject of this paper. Thus, a mapping of the mandatory attributes defined in the second draft of the ISO/IEEE 11073-10406-d02 and the minimum SCP-ECG fields is presented, and various other capabilities of the SCP-ECG Standard (such as the messaging part) are also analyzed from an x73-PHD point of view. As a result, this paper addresses and analyzes the implications of some inconsistencies in the coordinated use of these two standards. Finally, a proof-of-concept implementation of the draft x73-PHD ECG device specialization is presented, along with the conversion from x73-PHD to SCP-ECG. This paper, therefore, provides recommendations for future implementations of telecardiology systems that are compliant with both x73-PHD and SCP-ECG.

  5. [MD PhD programs: Providing basic science education for ophthalmologists].

    Science.gov (United States)

    Spaniol, K; Geerling, G

    2015-06-01

    Enrollment in MD PhD programs offers the opportunity of a basic science education for medical students and doctors. These programs originated in the USA where structured programs have been offered for many years, but now German universities also run MD PhD programs. The MD PhD programs provided by German universities were investigated regarding entrance requirements, structure and financing modalities. An internet and telephone-based search was carried out. Out of 34 German universities 22 offered MD PhD programs. At 15 of the 22 universities a successfully completed course of studies in medicine was required for enrollment, 7 programs admitted medical students in training and 7 programs required a medical doctoral thesis, which had to be completed with at least a grade of magna cum laude in 3 cases. Financing required scholarships in many cases. Several German universities currently offer MD PhD programs; however, these differ considerably regarding entrance requirements, structure and financing. A detailed analysis investigating the success rates of these programs (e.g. successful completion and career paths of graduates) would be of benefit.

  6. Cellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)

    Energy Technology Data Exchange (ETDEWEB)

    McDonough,M.; Li, V.; Flashman, E.; Chowdhury, R.; Mohr, C.; Lienard, B.; Zondlo, J.; Oldham, N.; Clifton, I.; et al.

    2006-01-01

    Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation of hypoxia-inducible transcription factor (HIF). Hydroxylation of conserved prolyl residues in the HIF-{alpha} subunit, catalyzed by HIF prolyl-hydroxylases (PHDs), signals for its proteasomal degradation. The requirement of the PHDs for dioxygen links changes in dioxygen levels with the transcriptional regulation of the gene array that enables the cellular response to chronic hypoxia; the PHDs thus act as an oxygen-sensing component of the HIF system, and their inhibition mimics the hypoxic response. We describe crystal structures of the catalytic domain of human PHD2, an important prolyl-4-hydroxylase in the human hypoxic response in normal cells, in complex with Fe(II) and an inhibitor to 1.7 Angstroms resolution. PHD2 crystallizes as a homotrimer and contains a double-stranded {beta}-helix core fold common to the Fe(II) and 2-oxoglutarate-dependant dioxygenase family, the residues of which are well conserved in the three human PHD enzymes (PHD 1-3). The structure provides insights into the hypoxic response, helps to rationalize a clinically observed mutation leading to familial erythrocytosis, and will aid in the design of PHD selective inhibitors for the treatment of anemia and ischemic disease.

  7. PhD students’ expectations from their supervisors: A qualitative content analysis

    Directory of Open Access Journals (Sweden)

    SH Rimaz

    2015-03-01

    Full Text Available Introduction: Quality of research in PhD programs increases if supervisors become aware of students' expectations from them. This qualitative study aimed to explore expectations of PhD students from their supervisors was done.   Methods: This qualitative content analysis study was conducted on 22 graduated PhD students of Iran University of Medical Sciences, in 2014. The samples were purposefully selected and interviewed. All interviews were recorded and transcribed verbatim.   Results: After analyzing and coding data, it was found that PhD students have four main expectations from their supervisors. These expectations consist of scientific support including help with selection of subject, preparation and registration of proposal, data collection and support for writing and examination of the thesis. Developing scientific skills and help with preparing manuscripts were other expectations. Emotional-social support with five categories including relationship between supervisor-student, general expectations of supervisor, supervisor personality characteristics, needed emotional skills and social activities related to thesis and finally providing adequate resources including financial support and access to facilities inside and outside the university were among the other expectations.   Conclusion: PhD students need to scientific, emotional, social and material supports from their supervisors in the process of performing thesis. These expectations should be told to supervisors.

  8. Strategic innovation between PhD and DNP programs: Collaboration, collegiality, and shared resources.

    Science.gov (United States)

    Edwards, Joellen; Rayman, Kathleen; Diffenderfer, Sandra; Stidham, April

    2016-01-01

    At least 111 schools and colleges of nursing across the nation provide both PhD and DNP programs (AACN, 2014a). Collaboration between nurses with doctoral preparation as researchers (PhD) and practitioners (DNP) has been recommended as essential to further the profession; that collaboration can begin during the educational process. The purpose of this paper is to describe the development and implementation of successful DNP and PhD program collaboration, and to share the results of that collaboration in an educational setting. Faculty set strategic goals to maximize the effectiveness and efficiency of both new DNP and existing PhD programs. The goals were to promote collaboration and complementarity between the programs through careful capstone and dissertation differentiation, complementary residency activities, joint courses and inter-professional experiences; promote collegiality in a blended on-line learning environment through shared orientation and intensive on-campus sessions; and maximize resources in program delivery through a supportive organizational structure, equal access to technology support, and shared faculty responsibilities as appropriate to terminal degrees. Successes such as student and faculty accomplishments, and challenges such as managing class size and workload, are described. Collaboration, collegiality and the sharing of resources have strengthened and enriched both programs and contributed to the success of students, faculty. These innovative program strategies can provide a solid foundation for DNP and PhD collaboration. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Predicting the "graduate on time (GOT)" of PhD students using binary logistics regression model

    Science.gov (United States)

    Shariff, S. Sarifah Radiah; Rodzi, Nur Atiqah Mohd; Rahman, Kahartini Abdul; Zahari, Siti Meriam; Deni, Sayang Mohd

    2016-10-01

    Malaysian government has recently set a new goal to produce 60,000 Malaysian PhD holders by the year 2023. As a Malaysia's largest institution of higher learning in terms of size and population which offers more than 500 academic programmes in a conducive and vibrant environment, UiTM has taken several initiatives to fill up the gap. Strategies to increase the numbers of graduates with PhD are a process that is challenging. In many occasions, many have already identified that the struggle to get into the target set is even more daunting, and that implementation is far too ideal. This has further being progressing slowly as the attrition rate increases. This study aims to apply the proposed models that incorporates several factors in predicting the number PhD students that will complete their PhD studies on time. Binary Logistic Regression model is proposed and used on the set of data to determine the number. The results show that only 6.8% of the 2014 PhD students are predicted to graduate on time and the results are compared wih the actual number for validation purpose.

  10. The PH-D proposal - A manned mission to PHOBOS and Deimos

    Science.gov (United States)

    Singer, S. F.

    The rationale for a manned mission to the satellites of Mars is discussed. The view has been expressed that NASA must define a major program to follow the Shuttle and to utilize it. However, such a program could not be initiated and proceed without public support, and to obtain this support, public interest would have to be excited. It is shown that, of a number of possible targets for manned exploration in the solar system, Mars appears to be the only possible candidate. Attention is given to a comparison of three Mars missions, a Mars 1984 mission, a manned landing on Mars surface, a manned landing on Phobos and Deimos (Ph-D project), putting men in Mars orbit, the capabilities of the Ph-D mission, a description of the spacecraft, a Ph-D project operations plan, and aspects of timing, technology, and costs.

  11. Cooperative Localization for Multi-AUVs Based on GM-PHD Filters and Information Entropy Theory

    Directory of Open Access Journals (Sweden)

    Lichuan Zhang

    2017-10-01

    Full Text Available Cooperative localization (CL is considered a promising method for underwater localization with respect to multiple autonomous underwater vehicles (multi-AUVs. In this paper, we proposed a CL algorithm based on information entropy theory and the probability hypothesis density (PHD filter, aiming to enhance the global localization accuracy of the follower. In the proposed framework, the follower carries lower cost navigation systems, whereas the leaders carry better ones. Meanwhile, the leaders acquire the followers’ observations, including both measurements and clutter. Then, the PHD filters are utilized on the leaders and the results are communicated to the followers. The followers then perform weighted summation based on all received messages and obtain a final positioning result. Based on the information entropy theory and the PHD filter, the follower is able to acquire a precise knowledge of its position.

  12. Characterization of the porosity in Boom (Mol site, Belgium) and Opalinus (Mont Terri, Switzerland) clays - about the benefit of using ion beam milling tools and CRYO-SEM

    International Nuclear Information System (INIS)

    Desbois, G.; Houben, M.E.; Sholokhova, Y.; Urai, J.L.; Kukla, P.A.

    2010-01-01

    imaging of pore space at high resolution. The first of them is to use ion beam milling tools able to prepare smooth, damage free cross-sectioned surfaces. Two main ion source are available: (1) a broad ion beam (BIB, up to 3.5 mA) is suitable to produce large polished cross-sections area of few mm 2 , while the focused ion beam (FIB, 1 pA - 45 nA) is better used for fine and precise polished cross-sections area of about few μm 2 . The second alternative is to preserve the in-situ nanostructures of wet clay-stones by using cryogenic techniques in order to stabilize in-situ fluids at temperature of liquid nitrogen. A FIB/BIB-cryo- SEM instrument combines cryo-techniques to preserve wet samples, in-situ sample preparation by ion beam cross-sectioning (BIB or FIB) and observations of the stabilized microstructure at high resolution (SEM). Since the ion beam is directly embedded into the SEM, this instrument offers a unique way to get a direct access of the pore space in 3D by using a 'slice and view' procedure equivalent to nano-serial sectioning. This procedure allows us investigating the natural in-situ pore space as a 3D matrix. This contribution reports on a study of Boom and Opalinus clays from reference sites for research (respectively at Mol site, Belgium and Mont Terri, Switzerland) using cryo-SEM at cryogenic temperature, with ion beam cross-sectioning to prepare smooth, damage free surfaces. Pores commonly have crack-like tips, preferred orientation parallel to bedding and power law size distribution. We define a number of pore types depending on shape and location in the microstructure. 3-D reconstruction by serial cross-sectioning shows 3-D connectivity of the pore space and provide natural pore matrix for simulation of permeability using Lattice Boltzmann method. These findings offer a new insight into the morphology of pores and quantification of porosity down to nano-scale and provide the basis for microstructure-based models of transport in clays

  13. Science PhD career preferences: levels, changes, and advisor encouragement.

    Directory of Open Access Journals (Sweden)

    Henry Sauermann

    Full Text Available Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

  14. Science PhD career preferences: levels, changes, and advisor encouragement.

    Science.gov (United States)

    Sauermann, Henry; Roach, Michael

    2012-01-01

    Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

  15. Education of MSc and PhD Students in Fluid Power and Mechatronics at DTU

    DEFF Research Database (Denmark)

    Conrad, Finn

    1996-01-01

    The paper deals with education of MSc and PhD students in engineering areas fluid power and mechatronics at the Technical Univ of Denmark, DTU, Lyngby. The new education structure and programs for MSc and PhD students adapted to the change and development of technologies. Focus is on two of twenty...... engineering profilies:(1) Engineeing Design and Product Development and (2)Control Engineering which give possibilitie for specialisation in fluid power and mechatronics design and productdevelopment. Synthesis, design and self-learning competency have a high priority taking the importance of training...

  16. The 7th Workshop for PhD Students in Object-Oriented Systems

    DEFF Research Database (Denmark)

    1997-01-01

    the communication and cooperation between them. In a year of the PhDOOS network the workshop is the main event where we meet face-to-face. Between workshops we stay in touch through our mailing list. More information on the PhDOOS network can be found at http://purl.org/net/PhDOOS.......It is a tradition at ECOOP conferences to have a workshop for PhD students, conducted by the network of PhD Students in Object-Oriented Systems (PhDOOS). The purpose of this network is to help leveraging the collective resources of young researchers in the object community by improving...

  17. An interview with James Wilbur, Ph.D. General Manager, Life Sciences, Meso Scale Discovery.

    Science.gov (United States)

    Wilbur, James

    2004-06-01

    James L. Wilbur, Ph.D. received a Bachelor's degree from the University of California, San Diego and a Ph.D. in Chemistry from Stanford University. After completing an NIH Postdoctoral Fellowship with Professor George M. Whitesides in the Department of Chemistry at Harvard University, he joined IGEN International, Inc., where he held a variety of positions in Research and Development. During that time, he was part of the team that developed the core technology and products for Meso Scale Discovery. He assumed his current position in 2001 when Meso Scale Discovery launched the products discussed here.

  18. A Content Analysis on the Subjects of Hospitality PhD Dissertations in Turkey

    Directory of Open Access Journals (Sweden)

    İbrahim GİRİTLİOĞLU

    2014-12-01

    Full Text Available The aim of this paper is to review the evaluation of hospitality dissertations as their subjects and their completed years. To perform on this aim, completed PhD dissertations were reached on National Dissertation Centre website at Turkish Higher Education Institute (YOK. According to study’s results, hospitality marketing strategies and organizational behavior in hospitality industry were the most popular research subjects on the dissertations in Turkey. However, the most completed PhD dissertations at the hospitality area was the year of 2011

  19. Deconstructing doctoral dissertations: how many papers does it take to make a PhD?

    Science.gov (United States)

    Hagen, Nils T

    2010-11-01

    A collection of coauthored papers is the new norm for doctoral dissertations in the natural and biomedical sciences, yet there is no consensus on how to partition authorship credit between PhD candidates and their coauthors. Guidelines for PhD programs vary but tend to specify only a suggested range for the number of papers to be submitted for evaluation, sometimes supplemented with a requirement for the PhD candidate to be the principal author on the majority of submitted papers. Here I use harmonic counting to quantify the actual amount of authorship credit attributable to individual PhD graduates from two Scandinavian universities in 2008. Harmonic counting corrects for the inherent inflationary and equalizing biases of routine counting methods, thereby allowing the bibliometrically identifiable amount of authorship credit in approved dissertations to be analyzed with unprecedented accuracy. Unbiased partitioning of authorship credit between graduates and their coauthors provides a post hoc bibliometric measure of current PhD requirements, and sets a de facto baseline for the requisite scientific productivity of these contemporary PhD's at a median value of approximately 1.6 undivided papers per dissertation. Comparison with previous census data suggests that the baseline has shifted over the past two decades as a result of a decrease in the number of submitted papers per candidate and an increase in the number of coauthors per paper. A simple solution to this shifting baseline syndrome would be to benchmark the amount of unbiased authorship credit deemed necessary for successful completion of a specific PhD program, and then monitor for departures from this level over time. Harmonic partitioning of authorship credit also facilitates cross-disciplinary and inter-institutional analysis of the scientific output from different PhD programs. Juxtaposing bibliometric benchmarks with current baselines may thus assist the development of harmonized guidelines and

  20. Top tips for PhD thesis examination: nurse clinicians, researchers and novices.

    Science.gov (United States)

    Cleary, Michelle; Horsfall, Jan; Hunt, Glenn E

    2012-01-01

    Interestingly, there are very few guidelines in the literature to assist novice nurse PhD examiners. In this paper, we aim to provide information to nurses, researchers or early career academics who have little experience in assessing a university thesis. The article provides background information about recent changes in the university sector; overviews some research on experienced examiners views; presents factors that differentiate between high and low quality PhD theses; and outlines some pointers that may be useful when marking at the doctoral level. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. PhD Crisis Discourse: A Critical Approach to the Framing of the Problem and Some Australian "Solutions"

    Science.gov (United States)

    Cuthbert, Denise; Molla, Tebeje

    2015-01-01

    A feature of HE reform discourse is the tendency to construct the rationale for reform in terms of averting calamity and risk. We refer to this risk talk as "crisis discourse." This study examines the formulation of PhD crisis discourse internationally and in Australia. We find that a key feature of PhD crisis discourse is that…

  2. PhD by Publication as an Argument for Innovation and Technology Transfer: With Emphasis on Africa

    Science.gov (United States)

    Asongu, Simplice A.; Nwachukwu, Jacinta C.

    2018-01-01

    The contribution of African researchers to knowledge by means of scientific publications is low compared to other regions of the world. This paper presents an argument in favour of PhD by publication as a tool for innovation and technology transfer. The conception of PhD by publication used in this study is more suited for doctorates in science…

  3. Challenges of PhD Graduated Nurses for Role Acceptance as a Clinical Educator: A Qualitative Study.

    Science.gov (United States)

    Haghighi Moghadam, Yousef; Atashzadeh-Shoorideh, Foroozan; Abbaszadeh, Abbas; Feizi, Aram

    2017-06-01

    Introduction: Clinical education is the core component of nursing education. PhD graduated nurses who are faculty members can play a main role in clinical instruction. However, there is not clear understanding about the challenges which they may encounter for accepting their role as clinical educator. The aim of this study was to explore the challenges of role acceptance by PhD aduated nurses who are faculty members. Methods: In this qualitative exploratory study a total of 13 participants (8 PhD graduated in nursing, 3 head of departments of nursing, one educational vice chancellor of nursing school, and one nurse) were selected by purposive sampling method. Data were collected by semi-structured, face to face interview and analyzed by conventional content analysis approach developed by Graneheim and Lundman. Results: The main theme emerged from data analysis was "identity threat". This theme had five categories including expectations beyond ability, lack of staff's rely on the performance of PhD graduated nurses, poor clinical competencies, doubtfulness, and obligation. Conclusion: PhD graduated nurses experienced some worries about their role as clinical educators and argued that they have not been prepared for their role. Therefore, policy makers and authorities of nursing schools should support PhD graduated nurses for accepting their new roles as clinical educators. Moreover, some changes in nursing PhD curriculum is needed to improve the clinical competencies of PhD graduated and prepare them for their role as a clinical educator.

  4. Meet EPA Scientist Betsy Smith, Ph.D.

    Science.gov (United States)

    Dr. Betsy Smith is Associate National Program Director for Systems Analysis within the Sustainable and Healthy Communities Research Program. Her work has focused on new methods to analyze spatial data on multiple problems.

  5. Using a nursing theory or a model in nursing PhD dissertations: a qualitative study from Turkey.

    Science.gov (United States)

    Mete, Samiye; Gokçe İsbir, Gozde

    2015-04-01

    The aim of this study was to reveal experiences of nursing students and their advisors using theories and models in their PhD dissertations. The study adopted a descriptive qualitative approach. This study was performed with 10 PhD candidates and their five advisors from nursing faculty. The results of the study were categorized into four. These are reasons for using a theory/model in a PhD dissertation, reasons for preferring a given model, causes of difficulties in using models in PhD dissertations, and facilitating factors of using theories and models in PhD of dissertations. It was also reported to contribute to the methodology of research and professional development of the students and advisors. © 2014 NANDA International, Inc.

  6. The intrinsically disordered domain of the antitoxin Phd chaperones the toxin Doc against irreversible inactivation and misfolding.

    Science.gov (United States)

    De Gieter, Steven; Konijnenberg, Albert; Talavera, Ariel; Butterer, Annika; Haesaerts, Sarah; De Greve, Henri; Sobott, Frank; Loris, Remy; Garcia-Pino, Abel

    2014-12-05

    The toxin Doc from the phd/doc toxin-antitoxin module targets the cellular translation machinery and is inhibited by its antitoxin partner Phd. Here we show that Phd also functions as a chaperone, keeping Doc in an active, correctly folded conformation. In the absence of Phd, Doc exists in a relatively expanded state that is prone to dimerization through domain swapping with its active site loop acting as hinge region. The domain-swapped dimer is not capable of arresting protein synthesis in vitro, whereas the Doc monomer is. Upon binding to Phd, Doc becomes more compact and is secured in its monomeric state with a neutralized active site. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  7. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark

    DEFF Research Database (Denmark)

    Raffing, Rie; Jensen, Thor Bern; Tønnesen, Hanne

    2017-01-01

    Background: Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students...... and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. Methods: A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health...... and Medical Sciences at the University of Copenhagen were interviewed. Empirical data were analysed using qualitative methods of analysis. Results: Overall, the results indicated a general interest in improved competence and development of a new supervision programme. Those who were not interested argued that...

  8. Three new students selected for the ATLAS PhD Grant Scheme

    CERN Multimedia

    Antonella Del Rosso

    2016-01-01

    Initiated in 2013, the ATLAS PhD Grant Scheme aims to enable young, talented and motivated students to work on part of their PhD thesis at CERN. The collaboration has just selected the three students who will start their theses in 2016.   The three students who received the ATLAS grant, which will cover part of their PhD studies. From left to right: Ruth Jacobs (Germany), Artem Basalaev (Russia), Nedaa B I Asbah (Palestine). The ATLAS PhD Grant Scheme was made possible thanks to a large donation by former ATLAS spokespersons Fabiola Gianotti and Peter Jenni, who started the fund with money from the Fundamental Physics Prize they received in 2013. Applications are handled by CERN HR, via this link. The aim of the initiative is to offer a unique educational opportunity to students within the ATLAS collaboration and to give them the possibility to continue their career in particle physics. Selected candidates receive a stipend allowing them to spend one year at CERN, followed by one year at their h...

  9. Regulating Emotions and Aiming for a Ph.D.: Excerpts from "Anthropology Matters"

    Science.gov (United States)

    Hovland, Ingie

    2012-01-01

    In this article I will present a range of experiences of graduate socialisation that have been discussed in past articles in the journal "Anthropology Matters". These are the experiences of social anthropology Ph.D. students in the United Kingdom. The overarching theme for the article is "regulating emotions", and the excerpts…

  10. International Students' Motivation to Pursue and Complete a Ph.D. in the U.S.

    Science.gov (United States)

    Zhou, Ji

    2015-01-01

    This study explores what motivates 19 international students to pursue a Ph.D. at a public research university in the U.S. and, more importantly, what motivates them to persist despite unsatisfying socialization. Based on value-expectancy achievement motivation theory, four motivations emerged: intrinsic interest in research, intrinsic interest in…

  11. Temporary Contracts: Effect on Job Satisfaction and Personal Lives of Recent Phd Graduates

    Science.gov (United States)

    Waaijer, Cathelijn J. F.; Belder, Rosalie; Sonneveld, Hans; van Bochove, Cornelis A.; van der Weijden, Inge C. M.

    2017-01-01

    In this study, we assess the effects of temporary employment on job satisfaction and the personal lives of recent PhD graduates. Temporary employment is becoming increasingly prevalent in many sectors, but has been relatively common in academia, especially for early career scientists. Labor market theory shows temporary employment to have a…

  12. Temporary contracts : Effect on job satisfaction and personal lives of recent PhD graduates

    NARCIS (Netherlands)

    Waaijer, C.J.F.; Belder, R.; Sonneveld, H.; Van, Bochove C.A.; Van, der Weijden I.C.M.

    2017-01-01

    In this study, we assess the effects of temporary employment on job satisfaction and the personal lives of recent PhD graduates. Temporary employment is becoming increasingly prevalent in many sectors, but has been relatively common in academia, especially for early career scientists. Labor market

  13. Women Ph.D. Students in Engineering and a Nuanced Terrain: Avoiding and Revealing Gender

    Science.gov (United States)

    Erickson, Shelley K.

    2012-01-01

    Tensions regarding gender emerged from interviews conducted with 20 women Ph.D. students. This article does not focus explicitly on the reasons for women's continued underrepresentation in engineering. Rather the students' explanations for underrepresentation serve as a case study with which to analyze their gendered experiences. They avoid freely…

  14. The Impact of Institutional Student Support on Graduation Rates in US Ph.D. Programmes

    Science.gov (United States)

    Bolli, Thomas; Agasisti, Tommaso; Johnes, Geraint

    2015-01-01

    Using National Research Council data, we investigate the determinants of graduation rates in US Ph.D. programmes. We emphasise the impact that support and facilities offered to doctoral students have on completion rates. Significant, strong and positive effects are found for the provision of on-site graduate conferences and dedicated workspace,…

  15. The first recipients of the ATLAS PhD Grant Scholarship Programme 2014

    CERN Multimedia

    Marcelloni, Claudia

    2014-01-01

    First recipients of the ATLAS PhD Grant Scholarship 2014 : With certificates, Lailin Xu, Josefina Alconada, and Gagik Vardanyan. The selection committee members, IFAE Barcelona’s Martine Bosman, Fabiola Gianotti, Peter Jenni and from CERN HR James PurvisProgramme: Lailin Xu, Josefina Alconada, and Gagik Vardanyan

  16. Gender and Doctoral Studies: The Perceptions of Ph.D. Students in an American University

    Science.gov (United States)

    Kurtz-Costes, Beth; Helmke, Laura Andrews; Ulku-Steiner, Beril

    2006-01-01

    Twenty students enrolled in Ph.D. programmes were interviewed to examine the role of gender in their academic experiences. Gender was examined in three ways: gender of the student, gender of the student's faculty supervisor and gender make-up of the faculty within the student's department or academic unit. All students reported the importance of…

  17. Learning Opportunities in PhD Supervisory Talks: A Social Constructionist Perspective

    Science.gov (United States)

    Tian, Wenwen; Singhasiri, Wareesiri

    2016-01-01

    Although PhD supervision has been recognised as an educative process and a complex pedagogy for decades, there is little research into on-site pedagogic processes. Informed by social constructionism and a Foucauldian approach, this qualitative case study explores how learning opportunities were created by analysing both a supervisor's verbal…

  18. Crystallization of Doc and the Phd-Doc toxin-antitoxin complex.

    Science.gov (United States)

    Garcia-Pino, Abel; Dao-Thi, Minh-Hoa; Gazit, Ehud; Magnuson, Roy David; Wyns, Lode; Loris, Remy

    2008-11-01

    The phd/doc addiction system is responsible for the stable inheritance of lysogenic bacteriophage P1 in its plasmidic form in Escherichia coli and is the archetype of a family of bacterial toxin-antitoxin modules. The His66Tyr mutant of Doc (Doc(H66Y)) was crystallized in space group P2(1), with unit-cell parameters a = 53.1, b = 198.0, c = 54.1 A, beta = 93.0 degrees . These crystals diffracted to 2.5 A resolution and probably contained four dimers of Doc in the asymmetric unit. Doc(H66Y) in complex with a 22-amino-acid C-terminal peptide of Phd (Phd(52-73Se)) was crystallized in space group C2, with unit-cell parameters a = 111.1, b = 38.6, c = 63.3 A, beta = 99.3 degrees , and diffracted to 1.9 A resolution. Crystals of the complete wild-type Phd-Doc complex belonged to space group P3(1)21 or P3(2)21, had an elongated unit cell with dimensions a = b = 48.9, c = 354.9 A and diffracted to 2.4 A resolution using synchrotron radiation.

  19. Originality and the PhD: what is it and how can it be demonstrated?

    Science.gov (United States)

    Gill, Paul; Dolan, Gina

    2015-07-01

    To explore the concept of originality in doctoral research and outline ways in which doctoral candidates can begin to identify, formulate and articulate their individual contributions to knowledge. Originality is a major feature of doctoral research but considerable confusion exists regarding what can and cannot constitute originality in the PhD and how the contribution to knowledge can be demonstrated clearly. This is a discussion paper. A review of relevant, published literature relating to originality in the PhD. Many doctoral candidates merely outline why they believe their work to be original, instead of demonstrating critically how and in what way their research makes a meaningful contribution to the body of knowledge. The concept of originality in the PhD is complex and multi-faceted. Identifying and conveying originality in doctoral research takes considerable time, contemplation and effort. This process is, however, integral to the PhD itself, and the skills acquired are essential for post-doctoral development. A good doctoral thesis should clearly outline the different ways in which the work is original. A succinct, focused, critical appraisal of the specific contribution to knowledge is preferable to an exhaustive list.

  20. An Analysis of Written Feedback on a PhD Thesis

    Science.gov (United States)

    Kumar, Vijay; Stracke, Elke

    2007-01-01

    This paper offers an interim analysis of written feedback on a first draft of a PhD thesis. It first looks at two sources of data: in-text feedback and overall feedback. Looking at how language is used in its situational context, we then coded the feedback and developed a model for analysis based on three fundamental functions of speech:…

  1. Classifying Australian PhD Theses: Linking Research and Library Practices

    Science.gov (United States)

    Macauley, Peter; Evans, Terry; Pearson, Margot

    2010-01-01

    This article draws on the findings from, and the methods and approach used in the provision of a database of Australian PhD thesis records for the period 1987 to 2006, coded by Research Fields, Courses and Disciplines (RFCD) fields of study. Importantly, the project was not merely the creation of yet another database but something that constitutes…

  2. Three graduate students receive Virginia Tech's first AdvanceVT Ph.D. fellowships

    OpenAIRE

    Cox, Clara B.

    2004-01-01

    AdvanceVT, a comprehensive program that promotes and enhances the careers of women in science and engineering, has awarded its first three Ph.D. fellowships as part of an ongoing effort to increase the number of women electing to pursue academic careers.

  3. Identification and characterization of small molecule inhibitors of a PHD finger§

    Science.gov (United States)

    Wagner, Elise K.; Nath, Nidhi; Flemming, Rod; Feltenberger, John B.; Denu, John M.

    2012-01-01

    A number of histone-binding domains are implicated in cancer through improper binding of chromatin. In a clinically reported case of acute myeloid leukemia (AML), a genetic fusion protein between nucleoporin 98 and the third plant homeodomain (PHD) finger of JARID1A drives an oncogenic transcriptional program that is dependent on histone binding by the PHD finger. By exploiting the requirement for chromatin binding in oncogenesis, therapeutics targeting histone readers may represent a new paradigm in drug development. In this study, we developed a novel small molecule screening strategy that utilizes HaloTag technology to identify several small molecules that disrupt binding of the JARID1A PHD finger to histone peptides. Small molecule inhibitors were validated biochemically through affinity pull downs, fluorescence polarization, and histone reader specificity studies. One compound was modified through medicinal chemistry to improve its potency while retaining histone reader selectivity. Molecular modeling and site-directed mutagenesis of JARID1A PHD3 provided insights into the biochemical basis of competitive inhibition. PMID:22994852

  4. Measuring efficiency of university-industry Ph.D. projects using best worst method

    NARCIS (Netherlands)

    Salimi, N.; Rezaei, J.

    2016-01-01

    A collaborative Ph.D. project, carried out by a doctoral candidate, is a type of collaboration between university and industry. Due to the importance of such projects, researchers have considered different ways to evaluate the success, with a focus on the outputs of these projects. However, what

  5. Measuring efficiency of university-industry Ph.D. projects using best worst method.

    Science.gov (United States)

    Salimi, Negin; Rezaei, Jafar

    A collaborative Ph.D. project, carried out by a doctoral candidate, is a type of collaboration between university and industry. Due to the importance of such projects, researchers have considered different ways to evaluate the success, with a focus on the outputs of these projects. However, what has been neglected is the other side of the coin-the inputs. The main aim of this study is to incorporate both the inputs and outputs of these projects into a more meaningful measure called efficiency. A ratio of the weighted sum of outputs over the weighted sum of inputs identifies the efficiency of a Ph.D. The weights of the inputs and outputs can be identified using a multi-criteria decision-making (MCDM) method. Data on inputs and outputs are collected from 51 Ph.D. candidates who graduated from Eindhoven University of Technology. The weights are identified using a new MCDM method called Best Worst Method (BWM). Because there may be differences in the opinion of Ph.D. candidates and supervisors on weighing the inputs and outputs, data for BWM are collected from both groups. It is interesting to see that there are differences in the level of efficiency from the two perspectives, because of the weight differences. Moreover, a comparison between the efficiency scores of these projects and their success scores reveals differences that may have significant implications. A sensitivity analysis divulges the most contributing inputs and outputs.

  6. Rethinking the Ph.D. in English. Carnegie Essays on the Doctorate: English.

    Science.gov (United States)

    Lunsford, Andrea Abernethy

    The Carnegie Foundation commissioned a series of essays as part of the Carnegie Initiative on the Doctorate (CID). The essays and essayists represent six disciplines that are part of the CID: chemistry, education, English, history, mathematics, and neuroscience. The essay explores the Ph.D. in English and suggests changes the author would make in…

  7. Winning the PhD Game: Evocative Playing of Snakes and Ladders

    Science.gov (United States)

    Dickie, Carolyn

    2011-01-01

    The purpose of this paper is to describe a qualitative approach to developing an understanding of the lived experiences of PhD students. Rather than relying on textbook reports and theories about studying a higher degree by research, by allowing the students' voices to be heard, explicit and conscious research can be used to generate appropriate…

  8. Liberal Arts Colleges and the Production of PhD Economists

    Science.gov (United States)

    Jefferson, Philip N.; Magenheim, Ellen

    2015-01-01

    Data from the National Science Foundation (2014) indicate that at least one PhD in economics was awarded to a Swarthmore College graduate in every year since 1966. The authors' purpose in this article is to consider factors that may have contributed to the high number of PhDs in economics awarded to Swarthmore College graduates. While there is…

  9. As others see us: what PhD students say about supervisors.

    Science.gov (United States)

    Yarwood-Ross, Lee; Haigh, Carol

    2014-09-01

    To explore the attitudes that doctoral students share with each other in an online postgraduate discussion forum. The supervisory role is pivotal to the successful completion of a PhD. Student satisfaction surveys are implemented by some universities, but there is currently no research that has investigated PhD students' experiences of supervision in the less formal environment of an online postgraduate discussion forum. Data were collected between September and December 2012 from the Postgraduate Forum, which receives posts from the global student community. The keywords used in the search were 'supervisor(s)' and 'supervision'. The data were analysed using thematic analysis. All relevant titles and posts from between January 2002 and the end of December 2012 were searched. The authors discovered five major themes: communication difficulties, control and engagement, academic bullying, lack of trust, and desertion. The relationship between students and supervisors is vital to successful PhD completion, and this study has provided some of the experiences students share with each other in an online postgraduate discussion forum. The online discussion forum provided an insight into students' perspectives of supervision but as it is asynchronous, there is limited analysis. Further research incorporating synchronous data collection methods would be helpful to examine students' experiences in greater detail. This study shows how an online postgraduate forum can be used as a source of data to gain an insight into PhD students' perspectives of supervision.

  10. Peer and Faculty Mentoring for Students Pursuing a PhD in Gerontology

    Science.gov (United States)

    Webb, Alicia K.; Wangmo, Tenzin; Ewen, Heidi H.; Teaster, Pamela B.; Hatch, Laurie R.

    2009-01-01

    The Graduate Center for Gerontology at the University of Kentucky incorporates three levels of mentoring in its PhD program. This project assessed satisfaction with peer and faculty mentoring and explored their perceived benefits and purposes. Core and affiliate faculty and current and graduated students were surveyed. Participants seemed…

  11. What We Know about the Dramatic Increase in PhD Degrees and ...

    African Journals Online (AJOL)

    Reforms in doctoral education are being shaped by the changing needs of society, of research modes, and of a changed labor markets for PhD holders. ... systems, such as the introduction of postgraduate schools that help implement and initiate innovations in doctoral education on a campus with an eye to high quality.

  12. Analysis of Citations to Books in Chemistry PhD Dissertations in an Era of Transition

    Science.gov (United States)

    Flaxbart, David

    2018-01-01

    A citation analysis of chemistry PhD dissertations at the University of Texas at Austin yielded data on how often graduate students cite books in their bibliographies, and on the characteristics of the books cited, in terms of age and local ownership. The analysis examined samples of dissertations selected from five discrete years--1988, 2006,…

  13. Work organization and mental health problems in PhD students

    NARCIS (Netherlands)

    Levecque, K.; Anseel, F.; Beuckelaer, A. de; Van Der Heyden, J.; Gisle, L.

    2017-01-01

    Research policy observers are increasingly concerned about the potential impact of current academic working conditions on mental health, particularly in PhD students. The aim of the current study is threefold. First, we assess the prevalence of mental health problems in a representative sample of

  14. Is a PhD a necessary requirement for lecturers in a`Medical School ...

    African Journals Online (AJOL)

    user

    2005-04-01

    Apr 1, 2005 ... universities did not require a PhD or equivalent qualifications as a minimum requirement for appointment to the ... report of 2002, Common-wealth year books. 1997/8 and 2002, ..... threatens to erode teaching standards and.

  15. ChemSession'08 - 5. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Madura, I.

    2008-01-01

    Book of Abstracts consists of short descriptions of presentations: 5 lectures and 127 posters presented during ChemSession'08 - 5 th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  16. UK PhD Assessment in Accounting and Finance: Social Capital in Action

    Science.gov (United States)

    Smith, Sarah Jane; Urquhart, Vivien

    2018-01-01

    Assessment lies at the centre of PhD degree quality standards, with quality assurance relying on independent external examiners. This study investigates the role of the viva and the selection of external examiners from within the accounting and finance discipline across UK institutions. A questionnaire survey and follow-up interviews with…

  17. ChemSession'09 - 6. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    2009-01-01

    Book of Abstracts contains short descriptions of presentations 3 lectures and 105 posters presented during ChemSession'09 - 6 th Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found

  18. Determinants of PhD Completion Time at the University of Ibadan ...

    African Journals Online (AJOL)

    Apart from conducting an extensive exploratory analysis on PhD production in the university, a binary logistic regression model was also fitted. The dichotomous responses were: completion on time and completion over time. The fitted logistic regression shows that only 10% of PhDs have predicted probability of completion ...

  19. Completing a PhD by Publication: A Review of Australian Policy and Implications for Practice

    Science.gov (United States)

    Jackson, Denise

    2013-01-01

    There is increasing impetus for higher-degree-by-research students to publish during candidature. Research performance, including higher degree completions and publication output, commonly determines university funding, and doctorates with publishing experience are better positioned for a career in softening academic labour markets. The PhD by…

  20. Exploring challenges of the reproductive health PhD curriculum: A qualitative research

    Directory of Open Access Journals (Sweden)

    Sh Kohan

    2016-07-01

    Full Text Available Introduction: Enhancing the quality and dynamicity of higher education programs requires continuous evaluation of curriculums. Reproductive health PhD program was established in 2006 in Iran while recommending that its curriculum be evaluated by assessing graduates’ performance in workplace and surveying students, faculty members and managers. This study aimed to explore challenges of the curriculum of reproductive health PhD program. Methods: Employing a qualitative content analysis approach and using purposive and sometimes opportunistic sampling, experiences and viewpoints of 33 graduates and students of reproductive health PhD program, educational managers and reproductive health board members about the curriculum of reproductive health PhD program were collected through individual interviews and notes in 2014-15. Data were transcribed and important expressions were coded. Classification of similar codes led to preliminary categories. Five main categories were extracted by further classifications. Results: The five main categories included inadequacy of course topics and contents, challenges of student education, failure in realizing curriculum goals, long research period, and ambiguity in graduates’ professional status were appeared; each of these included various subcategories. Conclusion: Results showed that the curriculum of reproductive health PhD program required revisions to meet the program’s mission and designing courses such as sexual health and reinforcing the clinical nature of the program were necessary. Moreover, the results emphasized that the establishment of an independent educational department of reproductive health for managing higher education affairs and greater supervision of the reproductive health board on educational affairs was necessary. Furthermore, reproductive health specialists should be employed in different positions to meet society’s reproductive health needs.

  1. Does working with industry come at a price? A study of doctoral candidates’ performance in collaborative vs. non-collaborative Ph.D. projects

    NARCIS (Netherlands)

    Salimi, Negin; Bekkers, Rudi; Frenken, Koen

    2015-01-01

    Collaborative Ph.D. projects between university and industry constitute an important aspect of university–industry collaboration, yet has remained under-researched thus far. The specific question this paper asks is how collaborative Ph.D. projects perform compared to non-collaborative Ph.D.

  2. Practicioner Profile: An Interview with Ted Klontz, Ph.D.

    Directory of Open Access Journals (Sweden)

    2010-10-01

    Full Text Available Dr. Ted Klontz is generally considered to be one the leading pioneers in the field of financial therapy. He defines his role as a consultant, but this simple term masks the important role he has played in changing the attitudes and behaviors of clients worldwide. His innovative work has been cited in the Wall Street Journal, the New York Times, and ABC’s 20/20 to name a few. Dr. Klontz currently serves on the Board of Directors of the Financial Therapy Association. In this interview the editors of the Journal of Financial Therapy ask questions related to what drives Dr. Klontz as a consultant/therapist.

  3. Career intentions of PhD students in nursing: A cross-sectional survey.

    Science.gov (United States)

    Bai, XiaoLing; Luo, ZhongChen; Lou, Ting; Pang, Jin; Tang, SiYuan

    2018-05-01

    Despite the rapid growth of Chinese nursing PhD programs, little is known about the career intentions of students in this field. To investigate the career intentions of nursing PhD students. Online cross-sectional survey. Nursing PhD students at Chinese universities. An online questionnaire was designed and the data were analyzed using SPSS. The mean age of the participants was 31.53 ± 4.92 years, and most were female (89.9%), married (74.2%), and had been employed previously (69.7%). Most intended to work in the city where their family lived (34.8%) or near their previous workplace (32.6%). Most (60.7%) desired to work in an educational institution (e.g., a university or college). The most common expected salary was 8000-11,999 RMB/month. The work benefits perceived as indispensable were "Five Insurances and One Fund" (77.5%), good educational resources for children (59.6%), financial allowances for PhD graduates (52.8%), staff dormitories/housing subsidies (50.6%), and tenure (50.6%). Nursing education (75.3%) and research (70.8%) were the most favored fields. The key job characteristics were the opportunity to put strengths to fullest use (79.8%), time to conduct research (60.7%), and work-life balance (51.7%). The key research conditions included a good research incentive mechanism (77.5%), a Basic Scientific Research Foundation (68.5%), opportunity to apply to conduct research projects (66.3%), and the nursing team's atmosphere regarding research (64.0%), and 91.0% were eager to study abroad (e.g., as part of an international exchange). Nursing PhD students would like to work in their hometown or near their previous workplace. Most preferred working in an educational institution, and the most popular fields were nursing education and research (rather than clinical care), despite the high demand of hospital management for nursing PhD graduates. Flexible work, high-quality research conditions, a certain salary, work benefits, and training were key

  4. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark

    Directory of Open Access Journals (Sweden)

    Rie Raffing

    2017-10-01

    Full Text Available Abstract Background Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Education Committee at the University of Copenhagen to recommend that supervisors further develop their supervision competence. The aim of this study was to explore PhD supervisors’ self-reported needs and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. Methods A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health and Medical Sciences at the University of Copenhagen were interviewed. Empirical data were analysed using qualitative methods of analysis. Results Overall, the results indicated a general interest in improved competence and development of a new supervision programme. Those who were not interested argued that, due to their extensive experience with supervision, they had no need to participate in such a programme. The analysis revealed seven overall themes to be included in the course. The clinical context offers PhD supervisors additional challenges that include the following sub-themes: patient recruitment, writing the first article, agreements and scheduled appointments and two main groups of students, in addition to the main themes. Conclusions The PhD supervisors reported the clear need and desire for a competence enhancement programme targeting the supervision of PhD students at the Faculty of Health and Medical Sciences. Supervision in the clinical context appeared to require additional competence. Trial registration The Scientific Ethical Committee

  5. Self-reported needs for improving the supervision competence of PhD supervisors from the medical sciences in Denmark.

    Science.gov (United States)

    Raffing, Rie; Jensen, Thor Bern; Tønnesen, Hanne

    2017-10-23

    Quality of supervision is a major predictor for successful PhD projects. A survey showed that almost all PhD students in the Health Sciences in Denmark indicated that good supervision was important for the completion of their PhD study. Interestingly, approximately half of the students who withdrew from their program had experienced insufficient supervision. This led the Research Education Committee at the University of Copenhagen to recommend that supervisors further develop their supervision competence. The aim of this study was to explore PhD supervisors' self-reported needs and wishes regarding the content of a new program in supervision, with a special focus on the supervision of PhD students in medical fields. A semi-structured interview guide was developed, and 20 PhD supervisors from the Graduate School of Health and Medical Sciences at the Faculty of Health and Medical Sciences at the University of Copenhagen were interviewed. Empirical data were analysed using qualitative methods of analysis. Overall, the results indicated a general interest in improved competence and development of a new supervision programme. Those who were not interested argued that, due to their extensive experience with supervision, they had no need to participate in such a programme. The analysis revealed seven overall themes to be included in the course. The clinical context offers PhD supervisors additional challenges that include the following sub-themes: patient recruitment, writing the first article, agreements and scheduled appointments and two main groups of students, in addition to the main themes. The PhD supervisors reported the clear need and desire for a competence enhancement programme targeting the supervision of PhD students at the Faculty of Health and Medical Sciences. Supervision in the clinical context appeared to require additional competence. The Scientific Ethical Committee for the Capital Region of Denmark. Number: H-3-2010-101, date: 2010.09.29.

  6. The training, careers, and work of Ph.D. physical scientists: Not simply academic

    Science.gov (United States)

    Smith, Steven J.; Pedersen-Gallegos, Liane; Riegle-Crumb, Catherine

    2002-11-01

    We present an in-depth portrait of the training, careers, and work of recent Ph.D. physical scientists. Use of specialized training varies widely, with about half often using knowledge of their Ph.D. specialty area in their jobs. The use of specialized training does not, however, correlate with job satisfaction. In this and other important measures, there are relatively few differences between "academics" and "nonacademics." Important job skills for all employment sectors include writing, oral presentation, management, data analysis, designing projects, critical thinking, and working in an interdisciplinary context. Rankings given by respondents of graduate training in some of these skill areas were significantly lower than the importance of these skills in the workplace. We also found that the rated quality of graduate training varies relatively little by department or advisor. Finally, although nonacademic aspirations among graduate students are fairly common, these do not appear to be well supported while in graduate school.

  7. Publication ethics from the perspective of PhD students of health sciences: a limited experience.

    Science.gov (United States)

    Arda, Berna

    2012-06-01

    Publication ethics, an important subtopic of science ethics, deals with determination of the misconducts of science in performing research or in the dissemination of ideas, data and products. Science, the main features of which are secure, reliable and ethically obtained data, plays a major role in shaping the society. As long as science maintains its quality by being based on reliable and ethically obtained data, it will be possible to maintain its role in shaping the society. This article is devoted to the presentation of opinions of PhD candidate students in health sciences in Ankara concerning publication ethics. The data obtained from 143 PhD students from the fields of medicine, dentistry, pharmacy and veterinary reveal limited but unique experiences. It also shows that plagiarism is one of the worst issues in the publication ethics from the perspective of these young academics.

  8. Examining the British PhD viva: opening new doors or scarring for life?

    Science.gov (United States)

    Carter, Bernie; Whittaker, Karen

    2009-01-01

    The PhD viva -- regardless of its format -- has the potential to be a significant rite of passage for the student. It is an experience that can resonate for months or years afterwards. Part of the challenge is that for everyone involved -- student, supervisory team and examiners -- a degree of end-point uncertainty exists. These ambiguities and tensions are perhaps an inherent part of any examination but are particularly characteristic of the examination of the individual and unique body of work that constitutes the doctoral thesis. In recent years, increased attention has been placed on the processes that surround the examination, aiming to increase transparency, consistency and fairness. However, the process of examining a student and their thesis remains challenging and is surrounded by different agendas, ideologies and practices. This paper examines some of the issues surrounding the PhD viva, primarily focusing on the British viva whilst weaving in commentary about the Australian system.

  9. Hydrogeologic characterization and evolution of the 'excavation damaged zone' by statistical analyses of pressure signals: application to galleries excavated at the clay-stone sites of Mont Terri (Ga98) and Tournemire (Ga03)

    International Nuclear Information System (INIS)

    Fatmi, H.; Ababou, R.; Matray, J.M.; Joly, C.

    2010-01-01

    Document available in extended abstract form only. This paper presents methods of statistical analysis and interpretation of hydrogeological signals in clayey formations, e.g., pore water pressure and atmospheric pressure. The purpose of these analyses is to characterize the hydraulic behaviour of this type of formation in the case of a deep repository of Mid- Level/High-Level and Long-lived radioactive wastes, and to study the evolution of the geologic formation and its EDZ (Excavation Damaged Zone) during the excavation of galleries. We focus on galleries Ga98 and Ga03 in the sites of Mont Terri (Jura, Switzerland) and Tournemire (France, Aveyron), through data collected in the BPP- 1 and PH2 boreholes, respectively. The Mont Terri site, crossing the Aalenian Opalinus clay-stone, is an underground laboratory managed by an international consortium, namely the Mont Terri project (Switzerland). The Tournemire site, crossing the Toarcian clay-stone, is an Underground Research facility managed by IRSN (France). We have analysed pore water and atmospheric pressure signals at these sites, sometimes in correlation with other data. The methods of analysis are based on the theory of stationary random signals (correlation functions, Fourier spectra, transfer functions, envelopes), and on multi-resolution wavelet analysis (adapted to nonstationary and evolutionary signals). These methods are also combined with filtering techniques, and they can be used for single signals as well as pairs of signals (cross-analyses). The objective of this work is to exploit pressure measurements in selected boreholes from the two compacted clay sites, in order to: - evaluate phenomena affecting the measurements (earth tides, barometric pressures..); - estimate hydraulic properties (specific storage..) of the clay-stones prior to excavation works and compare them with those estimated by pulse or slug tests on shorter time scales; - analyze the effects of drift excavation on pore pressures

  10. Hydro-mechanical analysis of results acquired by video-observations and deformation measurements performed in boreholes in the Opalinus clay of the URL Mont Terri supported by laboratory investigations on the hydro-mechanical behaviour of Opalinus clay

    International Nuclear Information System (INIS)

    Seeska, R.; Rutenberg, M.; Lux, K.H.

    2012-01-01

    Document available in extended abstract form only. Seven different boreholes in the Opalinus Clay formation of the Mont Terri Underground Rock Laboratory (URL Mont Terri) have been investigated by the Clausthal University of Technology (TUC) in cooperation with different partners with time, namely the National Cooperative for the Disposal of Radioactive Waste (NAGRA), the Federal Institute for Geosciences and Natural Resources (BGR) as well as the Swiss Federal Institute of Technology Zurich (ETHZ) and the Swiss Federal Nuclear Safety Inspectorate (ENSI). Aim of the investigations was to gain a large amount of high-quality and significant information on rock mass behaviour that can be used to increase knowledge about and improve understanding of time-dependent load-bearing and deformation behaviour of Opalinus Clay including pore water influences. For this purpose, an axial borehole camera and a three-arm calliper have been used. High-quality information on the load-bearing and deformation behaviour of the investigated boreholes was generated by the measurement and monitoring techniques used in the research project. The recordings reveal great as well as occasionally unexpected differences regarding the load-bearing behaviour as well as differences regarding the hydro-mechanical behaviour of the observed boreholes. While most of the boreholes have proved to be rather stable with only partial failure of the borehole wall in some areas, a complete borehole wall collapse occurred in two of the observed boreholes. The differences regarding the borehole wall stability and also the differences between the appearances of the occurring failure mechanisms are very likely due to the different orientation, the different locations within the URL Mont Terri, and the different facies the boreholes are located in. Figure 1 shows the time-dependent development of a borehole wall instability in one of the observed boreholes in a borehole section where an increase of moisture could

  11. Motivation in medical students: a PhD thesis report.

    Science.gov (United States)

    Kusurkar, Rashmi

    2012-08-01

    The aims of this thesis were to gather insights and investigate the factors influencing, outcomes and applications of medical students' motivation. This thesis consists of three literature reviews, four research papers and two application papers. Two research studies investigated the relationships of student motivation with study strategy, effort and academic performance through structural equation modelling and cluster analysis. The relationships of age, maturity, gender and educational background with motivation were investigated through multiple regression analysis. The results of this thesis were 1. Developments in medical education appear to have undervalued student motivation. 2. Motivation is an independent variable in medical education; intrinsic motivation is significantly associated with deep study strategy, high study effort and good academic performance. 3. Motivation is a dependent variable in medical education and is significantly affected by age, maturity, gender, educational background; intrinsic motivation is enhanced by providing students with autonomy, feedback and emotional support. 4. Strength of motivation for medical school can be reliably measured by Strength of Motivation for Medical School questionnaire. The conclusion of this thesis was that it is important to give consideration to motivation in medical education because intrinsic motivation leads to better learning and performance and it can be enhanced through giving students autonomy in learning, feedback about competence and emotional support.

  12. Earth and Space Science Ph.D. Class of 2003 Report released

    Science.gov (United States)

    Keelor, Brad

    AGU and the American Geological Institute (AGI) released on 26 July an employment study of 180 Earth and space science Ph.D. recipients who received degrees from U.S. universities in 2003. The AGU/AGI survey asked graduates about their education and employment, efforts to find their first job after graduation, and experiences in graduate school. Key results from the study include: The vast majority (87%) of 2003 graduates found work in the Earth and space sciences, earning salaries commensurate with or slightly higher than 2001 and 2002 salary averages. Most (64%) graduates were employed within academia (including postdoctoral appointments), with the remainder in government (19%), industry (10%), and other (7%) sectors. Most graduates were positive about their employment situation and found that their work was challenging, relevant, and appropriate for someone with a Ph.D. The percentage of Ph.D. recipients accepting postdoctoral positions (58%) increased slightly from 2002. In contrast, the fields of physics and chemistry showed significant increases in postdoctoral appointments for Ph.D.s during the same time period. As in previous years, recipients of Ph.D.s in the Earth, atmospheric, and ocean sciences (median age of 32.7 years) are slightly older than Ph.D. recipients in most other natural sciences (except computer sciences), which is attributed to time taken off between undergraduate and graduate studies. Women in the Earth, atmospheric,and ocean sciences earned 33% of Ph.D.s in the class of 2003, surpassing the percentage of Ph.D.s earned by women in chemistry (32%) and well ahead of the percentage in computer sciences (20%), physics (19%), and engineering (17%). Participation of other underrepresented groups in the Earth, atmospheric, and ocean sciences remained extremely low.

  13. ChemSession'10: 7. Warsaw Seminar of the PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Madura, I.

    2010-01-01

    Book of Abstracts contains short descriptions of presentations 4 lectures and 151 posters presented during ChemSession'10 - 7 th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 14.05.2010). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  14. Pathways to the PhD in Nursing: An Analysis of Similarities and Differences.

    Science.gov (United States)

    Nehls, Nadine; Barber, Gale; Rice, Elizabeth

    2016-01-01

    New educational pathways are needed to increase the number of doctor of philosophy (PhD)-prepared nurses. To address this need, an early-entry PhD option designed to engage students in PhD coursework and research during the undergraduate nursing major was developed at the University of Wisconsin-Madison. An evaluation comparing the early-entry option with two more conventional entry points was conducted. Three groups (N = 84) comprised the sample: (a) early-entry students admitted as undergraduates or immediately upon graduation (N = 29), (b) mid-entry students with baccalaureate degrees and at least 1 year of work experience (N = 27), and (c) delayed-entry students with master's degrees and 1 or more years of work experience (N = 28). Qualitative and quantitative data were collected from the 3 groups of students who were admitted from 2002 to 2011. The sources of data were transcriptions of individual interviews and reviews of existing data. Seventy-seven percent of the sample participated in the individual interviews. The database review included all students who matriculated into the PhD program. Common themes among the 3 groups included a need for educational funding, the importance of a faculty mentor, and concern about preparation for the teaching role and the academic work environment. The groups were also comparable in terms of research productivity during doctoral study and postgraduation employment. Differences were found on measures of diversity, program progression, and perceptions of clinical competence. The findings provide needed data for the development and expansion of educational pathways to the PhD in nursing. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Dražen Tutić, PhD in Technical Sciences

    Directory of Open Access Journals (Sweden)

    Miljenko Lapaine

    2009-12-01

    Full Text Available Dražen Tutić defended his PhD thesis Stereographic and Other Conformal Map Projections  for Croatia at the Faculty of Geodesy of the University of Zagreb on August 4, 2009. The thesis was evaluated by the Committee: Prof. Emeritus Nedjeljko Frančula, Prof. Dr. Miljenko Lapaine (mentor and Prof. Dr. Dušan Petrovič from the Faculty of Civil and Geodetic Engineering of the University of Ljubljana.

  16. ChemSession'06 - 3rd Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Zachara, J.; Lulinski, S.; Dobrowolski, J.C.; Raczynska, E.D.; Fuks, L.; Cyranski, M.K.; Stepien, B.T.; Sawicki, M.G.

    2006-01-01

    3 rd Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2006 participants presented 4 plenary lectures, and 109 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  17. Bucharest PhD Training School : Modern Aspects of Quantum Field Theory and Applications

    CERN Document Server

    2015-01-01

    Bucharest 2015 – Modern Aspects of Quantum Field Theory is part of the CERN – SEENET-MTP PhD Training Program, which consists of a number of seminars in theoretical high energy Physics. This is the second seminar organized by this Program. Here are some photos from this event held in Bucharest between 8-14 November 2015. The previous seminar was organized in Belgrade, under the name Belgrade 2015 - Supergravity.

  18. PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks

    OpenAIRE

    Baker, Lindsey A.; Allis, C. David; Wang, Gang G.

    2008-01-01

    Histone covalent modifications regulate many, if not all, DNA-templated processes, including gene expression and DNA damage response. The biological consequences of histone modifications are mediated partially by evolutionarily conserved “reader/effector” modules that bind to histone marks in a modification- and context-specific fashion and subsequently enact chromatin changes or recruit other proteins to do so. Recently, the Plant Homeodomain (PHD) finger has emerged as a class of specialize...

  19. ChemSession'11 - 8. Warsaw Seminar of the PhD Students in Chemistry - Abstracts

    International Nuclear Information System (INIS)

    Madura, I.

    2011-01-01

    Book of Abstracts contains short descriptions of presentations: 4 lectures, 1 communication and 149 posters presented during ChemSession'11 - 8 th Warsaw Seminar of the PhD Students in Chemistry (Warsaw, 13.05.2011). Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry, application of the radionuclides and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also mentioned.

  20. ChemSession'07 - 4th Seminary of Warsaw PhD Students in Chemistry. Abstracts

    International Nuclear Information System (INIS)

    Dobrowolski, J.C.; Ostrowski, S.; Madura, I.; Sporzynski, A.; Szatylowicz, H.; Zubrowska, A.

    2007-01-01

    4 th Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2007 participants presented 4 plenary lectures, and 101 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology

  1. Management of Stress and Anxiety Among PhD Students During Thesis Writing: A Qualitative Study.

    Science.gov (United States)

    Bazrafkan, Leila; Shokrpour, Nasrin; Yousefi, Alireza; Yamani, Nikoo

    2016-01-01

    Today, postgraduate students experience a variety of stresses and anxiety in different situations of academic cycle. Stress and anxiety have been defined as a syndrome shown by emotional exhaustion and reduced personal goal achievement. This article addresses the causes and different strategies of coping with this phenomena by PhD students at Iranian Universities of Medical Sciences. The study was conducted by a qualitative method using conventional content analysis approach. Through purposive sampling, 16 postgraduate medical sciences PhD students were selected on the basis of theoretical sampling. Data were gathered through semistructured interviews and field observations. Six hundred fifty-four initial codes were summarized and classified into 4 main categories and 11 subcategories on the thematic coding stage dependent on conceptual similarities and differences. The obtained codes were categorized under 4 themes including "thesis as a major source of stress," "supervisor relationship," "socioeconomic problem," and "coping with stress and anxiety." It was concluded that PhD students experience stress and anxiety from a variety of sources and apply different methods of coping in effective and ineffective ways. Purposeful supervision and guidance can reduce the cause of stress and anxiety; in addition, coping strategy must be in a thoughtful approach, as recommended in this study.

  2. "PhD Comics" author Jorge Cham on the power of procrastination

    CERN Multimedia

    Stefania Pandolfi

    2015-01-01

    From Tuesday, 22 to Friday, 25 September, Jorge Cham visited CERN. The PHD Movie 2 was screened in the Main Auditorium  and the cartoonist also took part in one of the Researchers' Night events.    Jorge Cham in the CERN Control Centre. On the first day, the author of the comic strip Piled Higher and Deeper (PhD Comics) visited the CERN Control Centre, the Synchrocyclotron, the CMS Service Cavern and the ATLAS control room. On Thursday, he had a busy afternoon, starting with signing copies of his books and then giving a talk entitled “The Power of Procrastination” in a packed Main Auditorium. He made the audience laugh by narrating his experience as a graduate student in robotics at Stanford University, recounting how he started drawing PhD Comics and how it rapidly became popular in universities all over the world. He then analysed the frustrations and anxieties commonly experienced by any graduate student, causing...

  3. Using Simulation in Nursing PhD Education: Facilitating Application of Responsible Conduct of Research Principles.

    Science.gov (United States)

    Clayton, Margaret F; Supiano, Katherine; Wilson, Rebecca; Lassche, Madeline; Latendresse, Gwen

    Simulation is a standard clinical nursing educational approach; however, simulation is rarely used in nonclinical nursing education. In doctor of philosophy (PhD) programs, ethical content about responsible conduct of research (RCR) is traditionally didactic, presented early in the program of study. Ethics content merits review before students begin the dissertation phase; thus, the purpose of this project was to design and implement simulated scenarios to help students apply RCR principles prior to beginning independent research. Two scenarios were developed: (a) a potential protocol change discussed in a research team meeting and (b) an in-home data collection experience with an elderly participant and her daughter. Actors were trained faculty volunteers, playing roles outside their usual academic positions. Faculty facilitated scenarios by posing questions as cues related to desired learning outcomes as scenarios unfolded. Eleven nursing PhD students and 6 faculty participated. Debriefing facilitated discussion of RCR principles, common research quandaries, and suggested scenario revisions. Faculty, expert observation, and video-review showed that younger and less experienced students tried to give the "right" answer rather than implement RCR appropriate solutions. Students with more clinical experience had difficulty adopting the less familiar researcher role. Overall, simulation is a novel and useful way to enhance RCR content in PhD programs. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Forensic odontology education:from undergraduate to PhD - a Brazilian experience.

    Science.gov (United States)

    Dietrichkeit Pereira, J G; Frontanilla Recalde, T S; Barreto Costa, P; Jacometti, V; Vigorito Magalhães, L; Alves Da Silva, R H

    2017-12-01

    Forensic Odontology is a topic present in the majority of Dental Schools in Brazil, and due to this reality, some universities develop activities related to undergraduate and graduate students, from the Dentistry course until the Ph.D. degree. To present the education experience related to Forensic Odontology at School of Dentistry of Ribeirão Preto (USP - University of São Paulo), showing the strategies and activities in the different degrees (Dental course, Forensic Odontology Specialization Program, Specific Professional Training, Master, and Ph.D.). To the undergraduate students, many activities are developed in order to demonstrate all the possibilities that Forensic Dentistry allow, including theoretical and practical activities; in the Forensic Odontology Specialization Program, the dentists are trained to act as Forensic Odontologists in all its amplitude; in the Specific Professional Training, some courses are available, related to specific topics as DVI, Forensic Facial Reconstruction, Auditor in Dental Care Insurance and others; and in the Master and Ph.D. Programs, the professionals receive training in skills like teaching, research, student's guidance and others. In Brazil, Forensic Odontology is a well-known field in Dentistry and universities develop an important role in training a qualified workforce.

  5. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

    Directory of Open Access Journals (Sweden)

    Javier Rodriguez

    2016-03-01

    Full Text Available Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been described for these enzymes. Using quantitative interaction proteomics, we screened for substrates of the proline hydroxylase PHD3 and the asparagine hydroxylase FIH, which regulate the HIF-mediated hypoxic response. We were able to identify hundreds of potential substrates. Enrichment analysis revealed that the potential substrates of both hydroxylases cluster in the same pathways but frequently modify different nodes of signaling networks. We confirm that two proteins identified in our screen, MAPK6 (Erk3 and RIPK4, are indeed hydroxylated in a FIH- or PHD3-dependent mechanism. We further determined that FIH-dependent hydroxylation regulates RIPK4-dependent Wnt signaling, and that PHD3-dependent hydroxylation of MAPK6 protects the protein from proteasomal degradation.

  6. Pioneering women in American mathematics the pre-1940 PhD's

    CERN Document Server

    Green, Judy

    2008-01-01

    More than 14 percent of the PhD's awarded in the United States during the first four decades of the twentieth century went to women, a proportion not achieved again until the 1980s. This book is the result of a study in which the authors identified all of the American women who earned PhD's in mathematics before 1940, and collected extensive biographical and bibliographical information about each of them. By reconstructing as complete a picture as possible of this group of women, Green and LaDuke reveal insights into the larger scientific and cultural communities in which they lived and worked. The book contains an extended introductory essay, as well as biographical entries for each of the 228 women in the study. The authors examine family backgrounds, education, careers, and other professional activities. They show that there were many more women earning PhD's in mathematics before 1940 than is commonly thought. Extended biographies and bibliographical information are available from the companion website fo...

  7. Biomedical Science Ph.D. Career Interest Patterns by Race/Ethnicity and Gender.

    Directory of Open Access Journals (Sweden)

    Kenneth D Gibbs

    Full Text Available Increasing biomedical workforce diversity remains a persistent challenge. Recent reports have shown that biomedical sciences (BMS graduate students become less interested in faculty careers as training progresses; however, it is unclear whether or how the career preferences of women and underrepresented minority (URM scientists change in manners distinct from their better-represented peers. We report results from a survey of 1500 recent American BMS Ph.D. graduates (including 276 URMs that examined career preferences over the course of their graduate training experiences. On average, scientists from all social backgrounds showed significantly decreased interest in faculty careers at research universities, and significantly increased interest in non-research careers at Ph.D. completion relative to entry. However, group differences emerged in overall levels of interest (at Ph.D. entry and completion, and the magnitude of change in interest in these careers. Multiple logistic regression showed that when controlling for career pathway interest at Ph.D. entry, first-author publication rate, faculty support, research self-efficacy, and graduate training experiences, differences in career pathway interest between social identity groups persisted. All groups were less likely than men from well-represented (WR racial/ethnic backgrounds to report high interest in faculty careers at research-intensive universities (URM men: OR 0.60, 95% CI: 0.36-0.98, p = 0.04; WR women: OR: 0.64, 95% CI: 0.47-0.89, p = 0.008; URM women: OR: 0.46, 95% CI: 0.30-0.71, p<0.001, and URM women were more likely than all other groups to report high interest in non-research careers (OR: 1.93, 95% CI: 1.28-2.90, p = 0.002. The persistence of disparities in the career interests of Ph.D. recipients suggests that a supply-side (or "pipeline" framing of biomedical workforce diversity challenges may limit the effectiveness of efforts to attract and retain the best and most

  8. Basics of SCI Rehabilitation

    Medline Plus

    Full Text Available ... PhD Sigmund Hough, PhD Laura Tuck, PsyD Terrie Price, PhD Heather Taylor, PhD Michelle Meade, PhD Jonathon ... the most important thing for families to know right away? play_arrow What are the main concerns ...

  9. Spinal Cord Injury 101

    Medline Plus

    Full Text Available ... PhD Sigmund Hough, PhD Laura Tuck, PsyD Terrie Price, PhD Heather Taylor, PhD Michelle Meade, PhD Jonathon ... arrow Why are high-dose steroids often used right after an injury? play_arrow What is meant ...

  10. Increasing PhD students’ employability by focusing on the academic entrepreneurship. The analysis of the entrepreneurial competences

    Directory of Open Access Journals (Sweden)

    Sabina Hodzic

    2016-05-01

    Full Text Available The aim of the present study was to explore the perspective for entrepreneurship among PhD students coming from variety of disciplines. More precisely, to identify the most important entrepreneurial competences for succeeding in the entrepreneurial venture, to explore whether these competences are being developed during the 3rd cycle studies, and to explore the entrepreneurial intentions of the future doctors. In order to choose the most important entrepreneurial competences, individual semi-structured interviews with ten entrepreneurs from different fields were conducted. In addition, the importance of each competence was evaluated in form of the questionnaire, by seventeen entrepreneurs. After the qualitative and quantitative analysis of the interviews and the questionnaire, 20 competences were selected as the most important entrepreneurial competences. These 20 competences were then evaluated by 50 PhD students from different fields of study. They evaluated the importance of each entrepreneurial competence, the level of its development during their PhD studies, and indicated their entrepreneurial intentions after finishing the PhD. The most important and the most developed competences are presented in the results. In addition, the results showed relatively high entrepreneurial intentions in case of not finding a job after the PhD and in general. These results imply the need for incorporating some sort of entrepreneurial training and the development of entrepreneurial competences adapted to each subject area during the PhD studies.

  11. Factors that facilitate or inhibit interest of domestic students in the engineering PhD: A mixed methods study

    Science.gov (United States)

    Howell Smith, Michelle C.

    Given the increasing complexity of technology in our society, the United States has a growing demand for a more highly educated technical workforce. Unfortunately, the proportion of United States citizens earning a PhD in engineering has been declining and there is concern about meeting the economic, national security and quality of life needs of our country. This mixed methods sequential exploratory instrument design study identified factors that facilitate or inhibit interest in engineering PhD programs among domestic engineering undergraduate students in the United States. This study developed a testable theory for how domestic students become interested in engineering PhD programs and a measure of that process, the Exploring Engineering Interest Inventory (EEII). The study was conducted in four phases. The first phase of the study was a qualitative grounded theory exploration of interest in the engineering PhD. Qualitative data were collected from domestic engineering students, engineering faculty and industry professional who had earned a PhD in engineering. The second phase, instrument development, developed the Exploring Engineering Interest Inventory (EEII), a measurement instrument designed with good psychometric properties to test a series of preliminary hypotheses related to the theory generated in the qualitative phase. In the third phase of the study, the EEII was used to collect data from a larger sample of junior and senior engineering majors. The fourth phase integrated the findings from the qualitative and quantitative phases. Four factors were identified as being significant influences of interest in the engineering PhD: Personal characteristics, educational environment, misperceptions of the economic and personal costs, and misperceptions of engineering work. Recommendations include increasing faculty encouragement of students to pursue an engineering PhD and programming to correct the misperceptions of the costs of the engineering PhD and the

  12. Publishing scientific papers based on Master's and Ph.D. theses from a small scientific community: case study of Croatian medical schools.

    Science.gov (United States)

    Frković, Vedran; Skender, Tomislav; Dojćinović, Bojan; Bilić-Zulle, Lidija

    2003-02-01

    To evaluate publishing activity of medical doctors after they have obtained Master's or Ph.D. degree at the Rijeka and Zagreb University Schools of Medicine in Croatia, and establish the number of journal articles based on these theses. Data on Master's and Ph.D. theses defended at the Rijeka and Zagreb University Schools of Medicine in the 1990-1999 period were collected by hand-search of the archive. MEDLINE and Current Contents databases were searched for journal articles resulting from the theses. During the 10-year period, 1,535 Master's and 634 Ph.D. theses were defended at the Rijeka and Zagreb University Schools of Medicine (253 Master's and 138 Ph.D. theses from Rijeka and 1,282 Master's and 496 Ph.D. theses from Zagreb). There were 201 (14%) Master's and 218 (34%) Ph.D. theses that resulted in articles published in journals indexed in MEDLINE (13% of Master's and 11% of Ph.D. theses from Rijeka, and 14% of Master's and 41% of Ph.D. theses from Zagreb). Also, 97 (6%) Master's and 129 (20%) Ph.D. theses that resulted in articles published in Current Contents journals (8% of Master's and 6% of Ph.D. theses from Rijeka, and 6% of Master's and 24% of Ph.D. theses from Zagreb). There was no significant difference between the two Universities with respect to published articles based on Master's theses, but there were significantly more articles from Ph.D. theses in Zagreb (ptheses resulted in a single publication (95%), 19 (5%) in 2, and 2 in 3 publications. Out of all 453 journal articles, 31% were published in Croatian and 69% in international journals. Most Croatian Master's and Ph.D. theses are not made available to the scientific community. There should be more institutional effort directed at the stimulation of postgraduate students to publish their scientific work.

  13. An interdepartmental Ph.D. program in computational biology and bioinformatics: the Yale perspective.

    Science.gov (United States)

    Gerstein, Mark; Greenbaum, Dov; Cheung, Kei; Miller, Perry L

    2007-02-01

    Computational biology and bioinformatics (CBB), the terms often used interchangeably, represent a rapidly evolving biological discipline. With the clear potential for discovery and innovation, and the need to deal with the deluge of biological data, many academic institutions are committing significant resources to develop CBB research and training programs. Yale formally established an interdepartmental Ph.D. program in CBB in May 2003. This paper describes Yale's program, discussing the scope of the field, the program's goals and curriculum, as well as a number of issues that arose in implementing the program. (Further updated information is available from the program's website, www.cbb.yale.edu.)

  14. Phd study of reliability and validity: One step closer to a standardized music therapy assessment model

    DEFF Research Database (Denmark)

    Jacobsen, Stine Lindahl

    The paper will present a phd study concerning reliability and validity of music therapy assessment model “Assessment of Parenting Competences” (APC) in the area of families with emotionally neglected children. This study had a multiple strategy design with a philosophical base of critical realism...... and pragmatism. The fixed design for this study was a between and within groups design in testing the APCs reliability and validity. The two different groups were parents with neglected children and parents with non-neglected children. The flexible design had a multiple case study strategy specifically...

  15. Synthesis of the PhD thesis "Anti-money laundering and counter terrorism financing management"

    Directory of Open Access Journals (Sweden)

    Camelia Popa

    2013-03-01

    Full Text Available As a whole, this PhD thesis follows three research lines, namely: (1 the conceptual line - concerns the definition of the money laundering and terrorism financing phenomenon, the processes, mechanisms, stages and instruments of the laundering of illegally obtained fund; (2 the estimative line aimed at measuring the size of money laundering phenomenon, the economic, social and security effects and consequences; (3 the line of an awareness of the need to prevent and fight against the effects arising from money laundering processes, the national and international efforts taken until present nation- and worldwide and the future measures required to diminish the consequences of this scourge.

  16. The first Italian doctorate (PhD Course) in Physics Education Research

    Science.gov (United States)

    Michelini, Marisa; Santi, Lorenzo

    2008-05-01

    The first PhD Italian course in Physics Education Research in Udine aims to qualify young researchers and teachers coming from all the Italian groups of research in the field. It becomes a context for developing research projects carried out following parallel research lines on: Teaching/Learning paths for didactic innovation, cognitive research, ICT for strategies to overcome conceptual knots in physics; E-learning for personalization; d) Computer on-line experiments and modelling; e) Teacher formation and training; f) Informal learning in science.

  17. HSI2/VAL1 PHD-like domain promotes H3K27 trimethylation to repress the expression of seed maturation genes and complex transgenes in Arabidopsis seedlings.

    Science.gov (United States)

    Veerappan, Vijaykumar; Chen, Naichong; Reichert, Angelika I; Allen, Randy D

    2014-11-01

    The novel mutant allele hsi2-4 was isolated in a genetic screen to identify Arabidopsis mutants with constitutively elevated expression of a glutathione S-transferase F8::luciferase (GSTF8::LUC) reporter gene in Arabidopsis. The hsi2-4 mutant harbors a point mutation that affects the plant homeodomain (PHD)-like domain in HIGH-LEVEL EXPRESSION OF SUGAR-INDUCIBLE GENE2 (HSI2)/VIVIPAROUS1/ABI3-LIKE1 (VAL1). In hsi2-4 seedlings, expression of this LUC transgene and certain endogenous seed-maturation genes is constitutively enhanced. The parental reporter line (WT LUC ) that was used for mutagenesis harbors two independent transgene loci, Kan R and Kan S . Both loci express luciferase whereas only the Kan R locus confers resistance to kanamycin. Here we show that both transgene loci harbor multiple tandem insertions at single sites. Luciferase expression from these sites is regulated by the HSI2 PHD-like domain, which is required for the deposition of repressive histone methylation marks (H3K27me3) at both Kan R and Kan S loci. Expression of LUC and Neomycin Phosphotransferase II transgenes is associated with dynamic changes in H3K27me3 levels, and the activation marks H3K4me3 and H3K36me3 but does not appear to involve repressive H3K9me2 marks, DNA methylation or histone deacetylation. However, hsi2-2 and hsi2-4 mutants are partially resistant to growth inhibition associated with exposure to the DNA methylation inhibitor 5-aza-2'-deoxycytidine. HSI2 is also required for the repression of a subset of regulatory and structural seed maturation genes in vegetative tissues and H3K27me3 marks associated with most of these genes are also HSI2-dependent. These data implicate HSI2 PHD-like domain in the regulation of gene expression involving histone modifications and DNA methylation-mediated epigenetic mechanisms.

  18. The bachelor's to Ph.D. STEM pipeline no longer leaks more women than men: a 30-year analysis.

    Science.gov (United States)

    Miller, David I; Wai, Jonathan

    2015-01-01

    For decades, research and public discourse about gender and science have often assumed that women are more likely than men to "leak" from the science pipeline at multiple points after entering college. We used retrospective longitudinal methods to investigate how accurately this "leaky pipeline" metaphor has described the bachelor's to Ph.D. transition in science, technology, engineering, and mathematics (STEM) fields in the U.S. since the 1970s. Among STEM bachelor's degree earners in the 1970s and 1980s, women were less likely than men to later earn a STEM Ph.D. However, this gender difference closed in the 1990s. Qualitatively similar trends were found across STEM disciplines. The leaky pipeline metaphor therefore partially explains historical gender differences in the U.S., but no longer describes current gender differences in the bachelor's to Ph.D. transition in STEM. The results help constrain theories about women's underrepresentation in STEM. Overall, these results point to the need to understand gender differences at the bachelor's level and below to understand women's representation in STEM at the Ph.D. level and above. Consistent with trends at the bachelor's level, women's representation at the Ph.D. level has been recently declining for the first time in over 40 years.

  19. Systematic analysis and comparison of the PHD-Finger gene family in Chinese pear (Pyrus bretschneideri) and its role in fruit development.

    Science.gov (United States)

    Cao, Yunpeng; Han, Yahui; Meng, Dandan; Abdullah, Muhammad; Li, Dahui; Jin, Qing; Lin, Yi; Cai, Yongping

    2018-04-20

    PHD-finger proteins, which belongs to the type of zinc finger family, and that play an important role in the regulation of both transcription and the chromatin state in eukaryotes. Currently, PHD-finger proteins have been well studied in animals, while few studies have been carried out on their function in plants. In the present study, 129 non-redundant PHD-finger genes were identified from 5 Rosaceae species (pear, apple, strawberry, mei, and peach); among them, 31 genes were identified in pear. Subsequently, we carried out a bioinformatics analysis of the PHD-finger genes. Thirty-one PbPHD genes were divided into 7 subfamilies based on the phylogenetic analysis, which are consistent with the intron-exon and conserved motif analyses. In addition, we identified five segmental duplication events, implying that the segmental duplications might be a crucial role in the expansion of the PHD-finger gene family in pear. The microsynteny analysis of five Rosaceae species showed that there were independent duplication events in addition to the genome-wide duplication of the pear genome. Subsequently, ten expressed PHD-finger genes of pear fruit were identified using qRT-PCR, and one of these genes, PbPHD10, was identified as an important candidate gene for the regulation of lignin synthesis. Our research provides useful information for the further analysis of the function of PHD-finger gene family in pear.

  20. An Analysis of Gender Differences in Recent Earth and Space Science PhD Graduates

    Science.gov (United States)

    Giesler, J.

    2001-12-01

    The American Geophysical Union (AGU) and the American Geological Institute (AGI) have been collecting data on recent PhDs in the geosciences for 5 years (1996-2000). The 1999-2000 PhD classes were combined for an increased sample size and analyzed for gender differences. Other than salary, place of employment, and job search methodology no differences were found. Females had salaries that were slightly lower than those of their male counterparts. This might be due to the fact that there are a greater number of female postdoctoral candidates 47% compared to males 40%. Place of employment tended to be similar with fewer women in industry and a higher number of recent female PhD graduates in the academic sector. Interestingly, men and women differed in the ways in which they found their first job. A higher percent of men reported they felt their advisor was helpful in their job search (52% for men and 50% for women). Women used electronic resources at a higher rate (17.3%) than men (12.1%) and 33.6% of the women felt their scientific society was helpful in their job search, compared to only 24.1% of the men.

  1. Pharmacoeconomics and outcomes research degree-granting PhD programs in the United States.

    Science.gov (United States)

    Slejko, Julia F; Libby, Anne M; Nair, Kavita V; Valuck, Robert J; Campbell, Jonathan D

    2013-01-01

    Evidence is missing on showcasing current practices of degree programs specific to the field of pharmaceutical outcomes research. To measure current practices of pharmacoeconomics and outcomes research PhD programs in the United States and synthesize recommendations for improving the success of programs and prospective students. A 23-question online survey instrument was created and distributed to 32 program directors identified in the International Society for Pharmacoeconomics and Outcomes Research educational directory. Descriptive statistics summarized both the program characteristics (including observed and desired number of faculty and students) and training recommendations (traits of program and student success). Of 30 eligible programs that conferred a PhD in pharmacoeconomics, pharmaceutical outcomes research, or a related field, 16 respondents (53%) completed the survey. Seventy-five percent of respondents were located in a school of pharmacy. The average observed number of faculty (7.5) and students (11.5) was lower than the average desired numbers (8.1) and (14.7), respectively. Reputation of faculty research and a collaborative environment with other disciplines were rated highest for a program's success. Faculty's mentoring experience and reputation and student funding opportunities were rated highest for prospective students' success. Existing and emerging programs as well as prospective students can use these findings to further their chances of success. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. [PhD theses on gerontological topics in Russia 1995-2012: scientometric analysis].

    Science.gov (United States)

    Smol'kin, A A; Makarova, E A

    2014-01-01

    The paper presents a scientometric analysis of PhD theses on gerontological topics in Russian humanities (excluding economics) for the period from 1995 to 2012. During this period, 253 PhD theses (238 of "candidate dissertations," and 15 of "doctoral dissertations") were defended in Russia. Almost half of them were defended during the boom years (2005-2006; 2009-2010). The number of theses defended in the 2000-s has increased significantly compared to the second half of 1990-s. However for gerontological PhD-s overall as a percentage of all theses defended in Russian humanities, the number hardly changed and remained small (less than 0.3%). The leading discipline in the study of aging (within the humanities) is sociology accounting for more than a third of all defended theses. Though the theses were defended in 48 cities, more than half of them were defended in 3 cities, which are Moscow, St. Petersburg and Saratov. Thematic analysis showed that the leading position was occupied by two topics: "the elderly and the state" (42%) and "(re)socialization/adaptation of the elderly" (25%). 14% of the works are devoted to intergenerational relations and social status of the elderly. Other topics (old man/woman's personality, self-perceptions of aging, violence and crime against the elderly, loneliness, discrimination, etc.) are presented by very few studies.

  3. Next gen PhD a guide to career paths in science

    CERN Document Server

    Sinche, Melanie V

    2016-01-01

    For decades, top scientists in colleges and universities pursued a clear path to success: enroll in a prestigious graduate program, conduct research, publish papers, complete the PhD, pursue postdoctoral work. With perseverance and a bit of luck, a tenure-track professorship awaited at the end. In today s academic job market, this scenario represents the exception. As the number of newly conferred science PhDs keeps rising, the number of tenured professorships remains stubbornly stagnant. Only 14 percent of those with PhDs in science occupy tenure-track positions five years after completing their degree. Next Gen PhD provides a frank and up-to-date assessment of the current career landscape facing science PhDs. Nonfaculty careers once considered Plan B are now preferred by the majority of degree holders, says Melanie Sinche. An upper-level science degree is a prized asset in the eyes of many employers, and a majority of science PhDs build rewarding careers both inside and outside the university. A certified ...

  4. First ‘Gentner Doktor’ finishes PhD at CERN

    CERN Multimedia

    Jordan Juras

    2011-01-01

    In 2007, the CERN Doctoral Student Programme saw the addition of the Gentner Doctoral Student Programme, named in honour of the celebrated nuclear physicist, Wolfgang Gentner. Four years later, on 22 June 2011, Marcel Schuh finished his PhD with a thesis in the field of accelerator technology and became the very first ‘Gentner Doktor’.   Marcel Schuh, first 'Gentner Doktor', celebrates completing his PhD. (Photo by Carsten P. Welsch) Marcel Schuh became a Gentner student in April 2008, after completing a physics degree in 2007 at the University of Heidelberg. His thesis allowed him to gain exposure to CERN and the LHC, as he worked on monitoring and control systems for trigger and readout electronics on the ALICE detector at the LHC. With the support of university supervisor, Carsten P. Welsch, Schuh applied for a Gentner Doctoral Studentship on the Superconducting Proton Linac (SPL) project. “My task was to evaluate whether dedicated higher order mode (HOM) coupler...

  5. Empirical Essays on the Labor Market Outcomes of PhD Graduates

    DEFF Research Database (Denmark)

    Pedersen, Heidi Skovgaard

    that PhDs accelerate growth. A major objective has been to direct more PhDs to the industry to use their skills to monetize knowledge. However, we have limited evidence on how PhDs are absorbed into the labor market, how the market values PhD labor, and how PhDs value the possibility to work......During the past decade, policy makers have accentuated the need for more PhDs to drive innovation and use their research skills to push the technological frontier. The public sector in Denmark has financially supported a doubling of the number of enrolled PhD students based on a strong belief...... in the private sector. The dissertation investigates determinants of labor market decisions among recent cohorts of PhDs in Denmark to assess how the increasing number of PhDs is absorbed into the economy. Based on econometric models, it examines what factors trigger individual career decisions and supply...

  6. Internationalization Impact on PhD Training Policy in Russia: Insights from The Comparative Document Analysis

    Directory of Open Access Journals (Sweden)

    Oksana Chigisheva

    2017-09-01

    Full Text Available The relevance of the study is due to the need for an objective picture of the Russian third level tertiary education transformation driven by internationalization issues and global trends in education. The article provides an analytical comparative review of the official documents related to the main phases of education reform in Russia and focuses on the system of PhD training which has undergone significant reorganization in recent years. A series of alterations introduced into the theory and practice of postgraduate education in Russia are traced in regulatory documents and interpreted in terms of growing internationalization demand. Possible implications for further development of the research human potential in Russia are being discussed. The method of comparative document analysis produces the best possible insight into the subject. The findings of the study contribute to the understanding of current challenges facing the system of doctoral studies in Russia and lead to certain conclusions on the transformation of educational policy in relation to PhD training under the influence of internationalization agenda.

  7. COMPARISON OF RESEARCH ENGAGEMENT OF PHD STUDENTS AT VARIOUS STUDY PROGRAMS AT CULS PRAGUE: AN INTRODUCTORY STUDY

    Directory of Open Access Journals (Sweden)

    FLÉGL, Martin

    2014-12-01

    Full Text Available In an attempt to improve the quality of doctoral studies and the satisfaction of PhD students at the Czech University of Life Sciences Prague (CULS Prague the authors disseminated online questionnaire among all PhD students in May and June 2014. The questionnaire covered areas related to doctoral study, PhD supervisors, doctoral scholarship, research publications, and last but not least, to satisfaction with the doctoral study. In this article responses related to research, such as allocation of time to doctoral studies, allocation of time to research, involvement in research projects and satisfaction with research outputs. The authors provide comparison of all above mentioned domains according to faculties as well as form of doctoral studies at CULS Prague.

  8. The Road to Become a Legitimate Scholar: A Case Study of International PhD Students in Science and Engineering

    Directory of Open Access Journals (Sweden)

    Pia Bøgelund

    2015-11-01

    Full Text Available The purpose of the doctoral education process is to create and legitimize scholarly researchers. This transformation, from student to scholar, is widely discussed in the literature. However, recent rapid changes in university culture have resulted in less time for supervision, stricter completion deadlines, and a greater focus on efficiency and productivity. This has had an impact on this transition process, and this impact has not been widely studied. The aim of this article is to understand the consequences of the current trends for PhD students and the education of PhD students in general. The article is based on interviews with 14 international students from two different research programs at the Faculty of Engineering and Science at Aalborg University in Denmark. The case of international PhD students in a western setting is singled out as a challenging case for becoming a legitimate scholar, since they face the additional challenge of becoming socialised into their new foreign setting. Overall, the study concludes that the transition process of doctoral students is affected by the way different supervisors deal with current university trends and how PhD students fit or do not fit into their knowledge production practices. The study identifies matches or mismatches in a knowledge production perspective, quality of contact, and degree of independence of the PhD student as factors that influence whether a transition process can be marked as sound, troublesome, or lacking. Finally, the study identifies an overall risk of neglecting the more interdependent types of international PhD students. Suggestions are given as how to address this risk.

  9. Customizing Process to Align with Purpose and Program: The 2003 MS PHD'S in Ocean Sciences Program Evaluative Case Study

    Science.gov (United States)

    Williamson, V. A.; Pyrtle, A. J.

    2004-12-01

    How did the 2003 Minorities Striving and Pursuing Higher Degrees of Success (MS PHD'S) in Ocean Sciences Program customize evaluative methodology and instruments to align with program goals and processes? How is data captured to document cognitive and affective impact? How are words and numbers utilized to accurately illustrate programmatic outcomes? How is compliance with implicit and explicit funding regulations demonstrated? The 2003 MS PHD'S in Ocean Sciences Program case study provides insightful responses to each of these questions. MS PHD'S was developed by and for underrepresented minorities to facilitate increased and sustained participation in Earth system science. Key components of this initiative include development of a community of scholars sustained by face-to-face and virtual mentoring partnerships; establishment of networking activities between and among undergraduate, graduate, postgraduate students, scientists, faculty, professional organization representatives, and federal program officers; and provision of forums to address real world issues as identified by each constituent group. The evaluative case study of the 2003 MS PHD'S in Ocean Sciences Program consists of an analysis of four data sets. Each data set was aligned to document progress in the achievement of the following program goals: Goal 1: The MS PHD'S Ocean Sciences Program will successfully market, recruit, select, and engage underrepresented student and non-student participants with interest/ involvement in Ocean Sciences; Goal 2: The MS PHD'S Ocean Sciences Program will provide meaningful engagement for participants as determined by quantitative analysis of user-feedback; Goal 3: The MS PHD'S Ocean Sciences Program will provide meaningful engagement for participants as determined by qualitative analysis of user-feedback, and; Goal 4: The MS PHD'S Ocean Sciences Program will develop a constituent base adequate to demonstrate evidence of interest, value, need and sustainability in

  10. The Market for Ph.D. Holders in Greece: Probit and Multinomial Logit Analysis of their Employment Status

    OpenAIRE

    Joan Daouli; Eirini Konstantina Nikolatou

    2015-01-01

    The objective of this paper is to investigate the factors influencing the probability that a Ph.D. holder in Greece will work in the academic sector, as well as the probability of his or her choosing employment in various sectors of industry and occupational categories. Probit/multinomial logit models are employed using the 2001 Census data. The empirical results indicate that being young, married, having a Ph.D. in Natural Sciences and/or in Engineering, granted by a Greek university, increa...

  11. 75 FR 16490 - Prospective Grant of Exclusive License: Development of PANVAC and Tumor Associated Antigens as...

    Science.gov (United States)

    2010-04-01

    ... exclusive license should be directed to: Sabarni K. Chatterjee, Ph.D. Licensing and Patenting Associate... indicates that Brachyury is aberrantly expressed on tumors of the lung, intestine, stomach, kidney, bladder...

  12. Tallinn ja Moskva austagu teineteist / Terry Davis

    Index Scriptorium Estoniae

    Davis, Terry

    2007-01-01

    Ilmunud ka: Molodjozh Estonii, 8. mai 2007, lk. 4; Postimees : na russkom jazõke, 9. mai 2007, lk. 9. Euroopa Nõukogu peasekretär mõistab hukka vandalismi ja rüüstamise Tallinna ja Moskva tänavatel Teise maailmasõja mälestusmärgi teisaldamise pärast ning ütleb, et on aeg käituda väärikalt nii teineteise kui mineviku suhtes, kuigi see võib olla vastuoluline

  13. Researcher Profile: An Interview with John E. Grable, Ph.D., CFP(R

    Directory of Open Access Journals (Sweden)

    John Grable

    2014-08-01

    Full Text Available John E. Grable, Ph.D., CFP(R teaches and conducts research in the Certified Financial Planner(TM Board of Standards undergraduate and graduate programs at the University of Georgia. Prior to entering the academic profession, he worked as a pension/benefits administrator and later as a Registered Investment Advisor in an asset management firm. He served as the founding editor for the Journal of Personal Finance and as the co-founding editor of the Journal of Financial Therapy. His research interests include financial risk-tolerance assessment, psychophysiological economics, and financial planning help-seeking behavior. Dr. Grable has published nearly 100 peer-reviewed papers, co-authored two financial planning textbooks, and co-edited a financial planning and counseling scales book. He currently writes a quarterly column for the Journal of Financial Service Professionals, serves as academic consultant to the Journal of Financial Planning, and chair the CFP Board Council on Education.

  14. Sample Size and Saturation in PhD Studies Using Qualitative Interviews

    Directory of Open Access Journals (Sweden)

    Mark Mason

    2010-08-01

    Full Text Available A number of issues can affect sample size in qualitative research; however, the guiding principle should be the concept of saturation. This has been explored in detail by a number of authors but is still hotly debated, and some say little understood. A sample of PhD studies using qualitative approaches, and qualitative interviews as the method of data collection was taken from theses.com and contents analysed for their sample sizes. Five hundred and sixty studies were identified that fitted the inclusion criteria. Results showed that the mean sample size was 31; however, the distribution was non-random, with a statistically significant proportion of studies, presenting sample sizes that were multiples of ten. These results are discussed in relation to saturation. They suggest a pre-meditated approach that is not wholly congruent with the principles of qualitative research. URN: urn:nbn:de:0114-fqs100387

  15. Investigator profile. An interview with Salvador Contreras Balderas, Ph.D. Interview by Vicki Glaser.

    Science.gov (United States)

    Contreras Balderas, Salvador

    2006-01-01

    Dr. Contreras Balderas is Professor Emeritus in the Department of Biology at Universidad Autonoma de Nuevo Leon (Monterrey, Mexico). He received a Master's degree and Ph.D. in Biological Sciences from Tulane University (New Orleans, LA) and wrote his dissertation on Ichthyology. He was awarded the President's Excellence Award of the American Fisheries Society. Dr. Contreras Balderas is Founder, President, and Honorary Member of the Mexican Society of Zoology, the Ichthyological Society of Mexico, and the Desert Fishes Council, is an ex-officio member of the Coalition for the Sustainable Development of the Rio Grande/Rio Bravo, U.S. & Mexico, and is a member of the U.S. Fish and Wildlife's Rio Grande Fishes Recovery Team. Dr. Contreras Balderas's areas of expertise include fish faunas, fishes at risk, exotic species, aquatic restoration, environmental impacts as detected by fishes, integral conservation, integral basin/ecosystem management, and ecological evaluation of integrity in basins.

  16. Instructors of psychotherapy in M.A. and Ph.D. clinical programs.

    Science.gov (United States)

    Stevens, H B

    1996-08-01

    The present study investigated the characteristics and orientations of the instructors of the initial psychotherapy course of the 44 members and affiliates of the Council of Applied Master's Programs in Psychology. Also examined were the focus of instruction in the course and the teachers' style of instruction. Responses for 26 completed surveys (58%) were compared with responses from instructors of initial psychotherapy courses in 69 of the 170 APA accredited doctoral programs. Five general theoretical orientations were represented by the M.A. instructors with 28% self-identifying as humanistic, 24% as dynamic, 20% as cognitive behavioral, 16% as interpersonal, and 12% as behavioral. No significant differences were found on demographic characteristics, theoretical orientation, focus of instruction, or method of instruction between instructors in M.A. and those in Ph.D. programs.

  17. Do PhD supervisors play a role in bridging academic cultures?

    DEFF Research Database (Denmark)

    Elliot, Dely; Kobayashi, Sofie

    Our study reports a phenomenological investigation of ten international PhD students’ and nine supervisors’ first-hand experience of being in doctoral supervisory relationships in a Danish setting. In-depth qualitative data were gathered through face-to-face individual interviews, which explored...... differences and challenges experienced as a result of diversity with respect to their educational background and practices, particularly the pedagogic variation. In the same way that the literature suggests that educators play a crucial role in mediating such diversity in the teaching and learning contexts...... relationship (that crosses over academic and non-academic concerns) and the distinct role it plays deserves further attention. Cotterall, S. (2013). More than just a brain: emotions and the doctoral experience. Higher Education Research & Development, 1-14. Wright, T. (2003). Postgraduate research students...

  18. Are MS in Economics Programs in Departments That Also Have a PhD Program in Economics Different from Their Counterparts?

    Science.gov (United States)

    Milkman, Martin I.; Marjadi, Riza; McCoy, James P.

    2016-01-01

    This is the first article that compares terminal master's degree programs in economics from universities that have a PhD program in economics with those that do not offer PhD programs in economics. The authors compare these differences based on surveys in 2002 and 2012. They examine differences in general program characteristics, department…

  19. Determinants of the Job Satisfaction of PhD Holders: An Analysis by Gender, Employment Sector, and Type of Satisfaction in Spain

    Science.gov (United States)

    Escardíbul, Josep-Oriol; Afcha, Sergio

    2017-01-01

    We analyze the determinants of job satisfaction of PhD holders in Spain. Specifically, we consider overall job satisfaction as well as basic and motivational satisfaction, following Herzberg's typology (based on Maslow's hierarchy of needs). Using representative data for Spain's PhD population--collected from the Spanish Survey on Human Resources…

  20. Serving Many Masters: The PhD on the Labour Market, the Everlasting Need of Inequality, and the Premature Death of Humboldt.

    Science.gov (United States)

    Enders, Jurgen

    2002-01-01

    Surveyed German doctoral degree holders to examine the processes and outcomes of doctoral training and their impact on subsequent careers and work affiliations. Found a positive outcome of the Ph.D. on the labor market, and that selection for doctoral training is biased by social origin while later career attainment among Ph.D. holders is not. (EV)

  1. What Matters for Excellence in PhD Programs? Latent Constructs of Doctoral Program Quality Used by Early Career Social Scientists

    Science.gov (United States)

    Morrison, Emory; Rudd, Elizabeth; Zumeta, William; Nerad, Maresi

    2011-01-01

    This paper unpacks how social science doctorate-holders come to evaluate overall excellence in their PhD training programs based on their domain-specific assessments of aspects of their programs. Latent class analysis reveals that social scientists 6-10 years beyond their PhD evaluate the quality of their doctoral program with one of two…

  2. Factors Influencing the Degree Progress of International PhD Students from Africa: An Exploratory Study

    Directory of Open Access Journals (Sweden)

    Almoustapha Oumarou Soumana

    2017-05-01

    Full Text Available In recent decades some countries of the Middle East have offered facilities to attract international students to pursue their higher education within their higher education institutions. The purpose of this study is to understand the difficulties faced by these students while conducting their studies abroad, and in doing so, to broaden the awareness of the challenges they face to complete their research. The participants of this qualitative study are international PhD students studying at a Middle Eastern public university. The university has reported increasing enrollment of international students, particularly from Africa in the last few years. Data were collected using a set of semi-structured interviews that drew out information on critical incidents that characterized the kind of difficulties students had faced in their studies. The data collected was further analyzed using a qualitative software package, NVivo (QSR International, 11. Six main themes came out from the content analysis of the interviews, which are the role of the adviser, student features, funding issues, family engagement, research and psychological obstacles which provide a holistic picture of student perspectives on the factors that influence degree progress. While these students might have faced difficulties mentioned in existing literature, this study argues that the participants have indicated experiencing psychological obstacles that were not described in earlier studies, such as the state of mind they were in as a result of being worried for family members due to war or violence in their home countries, and drop in currency exchange rates and difficulties in acquiring money due to international sanctions imposed against their countries. This study provides important thoughts on the factors that impact the degree progress of international PhD students from Africa, while at the same time revealing a serious gap in the advisers’ role which can contribute to the

  3. Examining students' views about validity of experiments: From introductory to Ph.D. students

    Science.gov (United States)

    Hu, Dehui; Zwickl, Benjamin M.

    2018-06-01

    We investigated physics students' epistemological views on measurements and validity of experimental results. The roles of experiments in physics have been underemphasized in previous research on students' personal epistemology, and there is a need for a broader view of personal epistemology that incorporates experiments. An epistemological framework incorporating the structure, methodology, and validity of scientific knowledge guided the development of an open-ended survey. The survey was administered to students in algebra-based and calculus-based introductory physics courses, upper-division physics labs, and physics Ph.D. students. Within our sample, we identified several differences in students' ideas about validity and uncertainty in measurement. The majority of introductory students justified the validity of results through agreement with theory or with results from others. Alternatively, Ph.D. students frequently justified the validity of results based on the quality of the experimental process and repeatability of results. When asked about the role of uncertainty analysis, introductory students tended to focus on the representational roles (e.g., describing imperfections, data variability, and human mistakes). However, advanced students focused on the inferential roles of uncertainty analysis (e.g., quantifying reliability, making comparisons, and guiding refinements). The findings suggest that lab courses could emphasize a variety of approaches to establish validity, such as by valuing documentation of the experimental process when evaluating the quality of student work. In order to emphasize the role of uncertainty in an authentic way, labs could provide opportunities to iterate, make repeated comparisons, and make decisions based on those comparisons.

  4. The multidisciplinary PhD course: A history and a way forward

    Directory of Open Access Journals (Sweden)

    Ruba Saleh

    2015-12-01

    Full Text Available This paper attempts to trace the last three decades of the PhD in Regional Planning and Public Policies (RPPP at Iuav, Venice.  The programme started in 1985; fifteen years after Giovanni Astengo established an undergraduate course in urban planning at the Iuav  Venice University of Architecture. Astengo was a leading authority on urban planning in the twentieth century, and the founder of the first graduate urban planning program in Italy. On the national level he was a vigorously active urban planner, who contributed both to the drafting of several Italian laws concerning the protection of the territory and landscape,(DOES "protection of the territory and landscape" simply mean 'the environment'? and a number of far-reaching plans. Astengo was the honorary president of the Italian National Institute of Planning (INU from 1986 to 1990.  He also re-founded the magazine Urbanistica, the magazine of the INU in 1949 and directed it for almost three decades.Another significant pioneer, Pierluigi Crosta who coordinated the course for two decades, was, and still is, a leader in the theory and development of the discipline.  Professor Crosta had a clear vision which he communicated to his students. In 2010, Crosta retired and many changes came about. A new coordinator was appointed with a new teaching plan. This paper has two objectives. First of all, it will aim to trace the contributions of Crosta to development of the subject at national level. Secondly, it will try to reflect the viewpoints of some of the PhD candidates who experienced the transition after Crosta, as a way to improve the methodology and organizational structure. Finally, it will speculate on the possibility of establishing a research centre at Iuav for the advancement of studies on contemporary cities.

  5. Support for PhD Students: The Impact of Institutional Dynamics on the Pedagogy of Learning Development

    Science.gov (United States)

    Peelo, Moira

    2013-01-01

    This paper explores one practitioner's learning development work with PhD students in a changing university context in which managerialism and financial stringency have combined. It questions how learning development practitioners can maintain their professional goals while negotiating issues arising from managerialism, financial stringency,…

  6. How to measure PhD. students' conceptions of academic writing - and are they related to well-being?

    Directory of Open Access Journals (Sweden)

    Kirsti Lonka

    2014-02-01

    Full Text Available This study investigated PhD students’ conceptions of writing and how they saw themselves as writers. The Writing Process Questionnaire was created to analyse PhD students’ ideas of academic writing. In addition, it was of interest, what the relation between conceptions of writing and the PhD students’ well-being was. The participants were 669 PhD students from a major Finnish university who volunteered to fill in a questionnaire. The present study covered scales for measuring six distinct theoretical constructs that were created by forming sum variables of 26 questions: Blocks, Procrastination, Perfectionism, Innate ability, Knowledge transforming, and Productivity. Confirmatory factor analysis (CFA was used to verify the six-dimension construct. Exhaustion, stress, anxiety and lack of interest all correlated positively with Blocks, Procrastination, and Perfectionism, and negatively with Productivity. Confirmatory factor analysis conducted by LISREL confirmed the six-factor structure of the writing scale. In conclusion, there is good evidence that the questionnaire is a reliable and valid tool, and it captures some essential aspectsof academic writing process and its emotional dimensions.

  7. Human radiation studies: Remembering the early years. Oral history of Biochemist Waldo E. Cohn, Ph.D

    International Nuclear Information System (INIS)

    1995-01-01

    In September 1994, the Department of Energy began an oral history project as part of the Openess initiative on the documentation of the human radiation experiments. This paper presents the oral history of Waldo E Cohn, Ph.D., a Biochemist who worked for the Oak Ridge National Laboratory and the Manhattan Project

  8. Trends in Ph.D. Productivity and Diversity in Top-50 U.S. Chemistry Departments: An Institutional Analysis

    Science.gov (United States)

    Laursen, Sandra L.; Weston, Timothy J.

    2014-01-01

    The education of doctoral chemists contributes to the chemical research enterprise and thus to innovation as an engine of the economy. This quantitative analysis describes trends in the production and diversity of chemistry Ph.D. degrees in the top-50 U.S. Ph.D.-granting departments in the past two decades. Time series data for individual…

  9. An Impact Analysis of Regional Industry--University Interactions: The Case of Industrial PhD Schools

    Science.gov (United States)

    Gustavsson, Linda; Nuur, Cali; Söderlind, Johan

    2016-01-01

    The authors discuss Triple Helix collaborations in the context of regional competitiveness. Through an exploratory case study, they identify and analyse the impact of the establishment of industrial PhD schools for participating industry and universities. The study was conducted in Sweden in 2014 and focuses on three industry--university…

  10. An Impact Analysis of Regional Industry-University Interactions: The Case of Industrial PhD Schools

    Science.gov (United States)

    Gustavsson, Linda; Nuur, Cali; Söderlind, Johan

    2016-01-01

    The authors discuss Triple Helix collaborations in the context of regional competitiveness. Through an exploratory case study, they identify and analyse the impact of the establishment of industrial PhD schools for participating industry and universities. The study was conducted in Sweden in 2014 and focuses on three industry-university…

  11. Research Productivity of LIS Schools in Pakistan: A Study of MPhil and PhD Theses to 2015

    Science.gov (United States)

    Sheikh, Arslan; Jan, Saeed Ullah

    2017-01-01

    This article aims to present a comprehensive review of MPhil and PhD research theses produced by library and information science (LIS) schools in Pakistan from their beginning to 2015. It also explores the research trends in LIS, identifies gaps, and presents an agenda for future research by LIS scholars. The origin, development, and current…

  12. PhD Students' Experiences of Thesis Supervision in Malaysia: Managing Relationships in the Midst of Institutional Change

    Science.gov (United States)

    Krauss, Steven Eric; Ismail, Ismi Arif

    2010-01-01

    Despite the plethora of studies that have been conducted on PhD supervision, little qualitative investigation has been conducted with a diverse, non-Western sample of doctoral students in an attempt to understand how the supervisory relationship is experienced. In response, eighteen students from diverse, non-Western backgrounds studying at one…

  13. Move-step structures of literature Ph.D. theses in the Japanese and UK higher education

    Directory of Open Access Journals (Sweden)

    Masumi Ono

    2017-02-01

    Full Text Available This study investigates the move-step structures of Japanese and English introductory chapters of literature Ph.D. theses and perceptions of Ph.D. supervisors in the Japanese and UK higher education contexts. In this study, 51 Japanese and 48 English introductory chapters of literature Ph.D. theses written by first language writers of Japanese or English were collected from three Japanese and three British universities. Genre analysis of 99 introductory chapters was conducted using a revised “Create a Research Space” (CARS model (Swales, 1990, 2004. Semi-structured interviews were also carried out with seven Japanese supervisors and ten British supervisors. The findings showed that the introductory chapters of literature Ph.D. theses had 13 move-specific steps and five move-independent steps, each of which presented different cyclical patterns, indicating cross-cultural similarities and differences between the two language groups. The perceptions of supervisors varied in terms of the importance and the sequence of individual steps in the introductory chapters. Based on the textual and interview analyses, a discipline-oriented Open-CARS model is proposed for pedagogical purposes of teaching and writing about this genre in Japanese or English in the field of literature and related fields.

  14. Assessment Procedures of Norwegian PhD Theses as Viewed by Examiners from the USA, the UK and Sweden

    Science.gov (United States)

    Kyvik, Svein

    2014-01-01

    This article focuses on the assessment procedures of Norwegian PhD theses as viewed by external members of evaluation committees from three countries with different examination systems; the USA, the UK and Sweden. Their viewpoints give useful information not only on the pros and cons with the Norwegian system, but also on the strengths and…

  15. Multimodal Identity Texts as Mediational Spaces in Researching Ph.D. Students' Critical Teacher-Researcher Selves

    Science.gov (United States)

    Valencia, Marlon; Herath, Sreemali

    2015-01-01

    This paper analyses how two Ph.D. students used multimodal identity texts (MMITs) to document their research journeys as they engaged in their doctoral studies. Drawing on qualitative data collected from multiple pre-service teacher preparation programmes in Chile and Sri Lanka, two bi-national researchers (a Colombian-Canadian and a Sri…

  16. Device interoperability and authentication for telemedical appliance based on the ISO/IEEE 11073 Personal Health Device (PHD) Standards.

    Science.gov (United States)

    Caranguian, Luther Paul R; Pancho-Festin, Susan; Sison, Luis G

    2012-01-01

    In this study, we focused on the interoperability and authentication of medical devices in the context of telemedical systems. A recent standard called the ISO/IEEE 11073 Personal Health Device (X73-PHD) Standards addresses the device interoperability problem by defining common protocols for agent (medical device) and manager (appliance) interface. The X73-PHD standard however has not addressed security and authentication of medical devices which is important in establishing integrity of a telemedical system. We have designed and implemented a security policy within the X73-PHD standards. The policy will enable device authentication using Asymmetric-Key Cryptography and the RSA algorithm as the digital signature scheme. We used two approaches for performing the digital signatures: direct software implementation and use of embedded security modules (ESM). The two approaches were evaluated and compared in terms of execution time and memory requirement. For the standard 2048-bit RSA, ESM calculates digital signatures only 12% of the total time for the direct implementation. Moreover, analysis shows that ESM offers more security advantage such as secure storage of keys compared to using direct implementation. Interoperability with other systems was verified by testing the system with LNI Healthlink, a manager software that implements the X73-PHD standard. Lastly, security analysis was done and the system's response to common attacks on authentication systems was analyzed and several measures were implemented to protect the system against them.

  17. Thai PhD Students and Their Supervisors at an Australian University: Working Relationship, Communication, and Agency

    Science.gov (United States)

    Nomnian, Singhanat

    2017-01-01

    PhD supervision is crucial for higher degree research students in western academic contexts. Despite an increasing body of literature regarding the international student-supervisor relationship, Thai students in Australian higher education are under-represented. This qualitative study aims to explore discursive practices that impact on Thai…

  18. A Study on Changes of Supervision Model in Universities and Fostering Creative PhD Students in China

    DEFF Research Database (Denmark)

    Luo, Lingling; Zhou, Chunfang; Zhang, Song

    2015-01-01

    This paper aims to explore the changes of supervision model in higher education in relation to fostering creative Ph.D. students in China. The changes are being made from the traditional Apprentice Master Model (AMM) to the modern Collaborative Cohort Model (CCM). According to the results...

  19. MS PHD'S: Bridging the Gap of Academic and Career Success Through Educational and Professional Development for Minorities

    Science.gov (United States)

    Brown, D.; Vargas, W.; Padilla, E.; Strickland, J.; Echols, E.; Johnson, A.; Williamson Whitney, V.; Ithier-Guzman, W.; Ricciardi, L.; Johnson, A.; Braxton, L.

    2011-12-01

    Historically, there has been a lack of ethnic and gender diversity in the geo-sciences. The Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Professional Development Program provides a bridge to young scientists of diverse backgrounds who in turn will impact many. In a process of 3 phases, the program introduces the students to the scientific community through participation in professional and society meetings and networking with scientists and personnel within federal agencies, academic institutions and STEM-based industries. The program builds confidence, offers role models for professional development and provides students support during their education. Upon completion, students achieve a high level of self-actualization and self-esteem combined with individual growth. They become part of a community that continuously provides support and security to each other. This support is tangible through the mentor/mentee relationships which will help with individual growth throughout the mentoring cycle. Having role models and familiar faces to whom mentees can relate to will encourage our students to succeed in the STEM's field. To date, 159 students have participated in the program: 26 have successfully completed their PhD and 56 are currently enrolled in the PhD programs nationwide. The MS PHD'S Program creates a forum of diverse peoples by diverse peoples with diverse interest and strength, where the ongoing goal is to continually raise the bar for each individual. MS PHD'S establishes a nurturing goal-oriented environment for the geo scientist of the future who in turn will make profound contributions on a local, national and global scale. To conclude, MSPHD'S not only bridges the gap of unrepresented minorities in STEM careers, but also generates educational approaches to make the earth system sciences available to more, impacting all.

  20. Persona Grata - Bernard Vanheusden, Contemporary Issues in International Law, an Interview with Associate Professor of Environmental Law, Hasselt University

    OpenAIRE

    Gordeeva, Yelena M.

    2016-01-01

    An Interview with an Associate Professor of Environmental Law, Law Faculty, Hasselt University, PhD in Law Bernard Vanheusden environmental law; climate change; European Environmental Law Forum; procedural environmental rights

  1. The Ph-D project: Manned expedition to the Moons of Mars

    Science.gov (United States)

    Singer, S. Fred

    2000-01-01

    The Ph-D (Phobos-Deimos) mission involves the transfer of six to eight men (and women), including two medical scientists, from Earth orbit to Deimos, the outer satellite of Mars. There follows a sequential program of unmanned exploration of the surface of Mars by means of some ten to twenty unmanned rover vehicles, each of which returns Mars samples to the Deimos laboratory. A two-man sortie descends to the surface of Mars to gain a direct geological perspective and develop priorities in selecting samples. At the same time, other astronauts conduct a coordinated program of exploration (including sample studies) of Phobos and Deimos. Bringing men close to Mars to control exploration is shown to have scientific and other advantages over either (i) (manned) control from the Earth, or (ii) manned operations from Mars surface. The mission is envisaged to take place after 2010, and to last about two years (including a three-to six-month stay at Deimos). Depending on then-available technology, take-off weight from Earth orbit is of the order of 300 tons. A preferred mission scheme may preposition propellants and equipment at Deimos by means of ``slow freight,'' possibly using a ``gravity boost'' from Venus. It is then followed by a ``manned express'' that conveys the astronauts more rapidly to Deimos. Both chemical and electric propulsion are used in this mission, as appropriate. Electric power is derived from solar and nuclear sources. Assuming that certain development costs can be shared with space-station programs, the incremental cost of the project is estimated as less than $40 billion (in 1998 dollars), expended over a 15-year period. The potential scientific returns are both unique and important: (i) Establishing current or ancient existence of life-forms on Mars; (ii) Understanding the causes of climate change by comparing Earth and Mars; (iii) Martian planetary history; (iv) Nature and origin of the Martian moons. Beyond the Ph-D Project, many advanced programs

  2. Improving Doctoral Success by Matching PhD Students with Supervisors

    Directory of Open Access Journals (Sweden)

    Antònia Darder

    2016-02-01

    Full Text Available A key aspect of the effective supervision of PhD research is the supervisor-student relationship. This interaction is affected by the characteristics and needs of students and institutional conditions, as well as the skills, attitudes, and roles of supervisors and their supervisory styles. When supervision is carried out at a distance, it entails an additional challenge, mainly concerning interaction. The purpose of this study is to improve the research process, supervision, and design of virtual environments in order to support this supervision. The study identifies the supervisory relationships that affect doctoral research conducted at a distance from the student’s academic institution. It also describes how students and their supervisors perceived the characteristics of supervision and the skills and attitudes students perceived in and expected from their supervisors. For data collection, semistructured interviews were used. The results indicate important differences between supervisors’ perceptions concerning their own role and students’ needs regarding supervision, and they demonstrate the importance of attending to student needs and, on the part of supervisors, exercising responsibility in the development of research competencies in students, as is the case of independence of criteria and autonomy.

  3. The postgraduate students’ (masters, PhD metaphors about education of statistic

    Directory of Open Access Journals (Sweden)

    Colak Serap

    2016-01-01

    Full Text Available Statistics is an important part of our life when it comes to economy, education, sport, politics and research. Research is a primary job for the ones pursuing academic career and statistics is one of the basic components of a research. Metaphor is used as an equivalent to figurative expression (‘mecaz’ in Turkish language. Study group is composed of 19 females (age 27.7 and 40 males (age 30.85 - 59 students in total. Demographic information of participants was collected. Participants were provided with questionnaire in order to assess their metaphorical creation whereby they were asked to fill in the sentence - “statistics is like/ similar to …, because…” - with metaphor. The study has collected total of 59 metaphors in 6 categories. The most created metaphor is in ‘discovering/ revealing’ category. 42.5% of Master’s students and 25% of PhD students are in this category. Metaphors created by graduate students are representing their views about statistics course and hence their view about importance of research. The category ‘discovering/ revealing’, the one with the most created metaphor of this study, is the main concept of science. Consequently, good knowledge of statistics is needed for graduate students to conduct research.

  4. Healing in forgiveness: A discussion with Amanda Lindhout and Katherine Porterfield, PhD

    Directory of Open Access Journals (Sweden)

    Katherine A. Porterfield

    2014-09-01

    Full Text Available In 2008, Amanda Lindhout was kidnapped by a group of extremists while traveling as a freelance journalist in Somalia. She and a colleague were held captive for more than 15 months, released only after their families paid a ransom. In this interview, Amanda discusses her experiences in captivity and her ongoing recovery from this experience with Katherine Porterfield, Ph.D. a clinical psychologist at the Bellevue/NYU Program for Survivors of Torture. Specifically, Amanda describes the childhood experiences that shaped her thirst for travel and knowledge, the conditions of her kidnapping, and her experiences after she was released from captivity. Amanda outlines the techniques that she employed to survive in the early aftermath of her capture, and how these coping strategies changed as her captivity lengthened. She reflects on her transition home, her recovery process, and her experiences with mental health professionals. Amanda's insights provide an example of resilience in the face of severe, extended trauma to researchers, clinicians, and survivors alike. The article ends with an discussion of the ways that Amanda's coping strategies and recovery process are consistent with existing resilience literature. Amanda's experiences as a hostage, her astonishing struggle for physical and mental survival, and her life after being freed are documented in her book, co-authored with Sara Corbett, A House in the Sky.

  5. The accuracy of references in PhD theses: a case study.

    Science.gov (United States)

    Azadeh, Fereydoon; Vaez, Reyhaneh

    2013-09-01

    Inaccurate references and citations cause confusion, distrust in the accuracy of a report, waste of time and unnecessary financial charges for libraries, information centres and researchers. The aim of the study was to establish the accuracy of article references in PhD theses from the Tehran and Tabriz Universities of Medical Sciences and their compliance with the Vancouver style. We analysed 357 article references in the Tehran and 347 in the Tabriz. Six bibliographic elements were assessed: authors' names, article title, journal title, publication year, volume and page range. Referencing errors were divided into major and minor. Sixty two percent of references in the Tehran and 53% of those in the Tabriz were erroneous. In total, 164 references in the Tehran and 136 in the Tabriz were complete without error. Of 357 reference articles in the Tehran, 34 (9.8%) were in complete accordance with the Vancouver style, compared with none in the Tabriz. Accuracy of referencing did not differ significantly between the two groups, but compliance with the Vancouver style was significantly better in the Tehran. The accuracy of referencing was not satisfactory in both groups, and students need to gain adequate instruction in appropriate referencing methods. © 2013 The authors. Health Information and Libraries Journal © 2013 Health Libraries Group.

  6. ANALYSIS OF METHODICAL DEFECTS IN PHD AND DOCTORAL THESIS ON ECONOMICS

    Directory of Open Access Journals (Sweden)

    R. D. Gutgarts

    2016-01-01

    Full Text Available The aim of the article is to consider the most typical defectswhich can be found in PhD and doctoral dissertations on economic sciences. The research is based on a work experience of the author as the member of dissertation council, the reviewer and the opponent of dissertation works.Methods. The methods of the analysis, comparison, and generalization are used while researching the problem.Results and scientific novelty. The miscalculations and errors in master’s and doctoral dissertations on economics which have methodical nature and not depend on a specific subject of work are disclosed and systematized. In particular, the following questions concerning the process of work are studied out on specific examples: work with information sources, Internet resources; options of correct and incorrect use o tools of information technologies; applied problems of results of scientific research, etc.Practical significance of the publication consists, firstly, in recommendations of the author concerning leveling and elimination of common defects of dissertation works and scientific articles; secondly, in the proposal of the general and methodical plan for introduction of training standards in a postgraduate study.

  7. Ballistic Target PHD Filter Based on Infrared Focal Plane Ambiguous Observation

    Directory of Open Access Journals (Sweden)

    Wei Zhao

    2017-01-01

    Full Text Available Space-based early warning system, the main detection means of which is passive detection based on focal plane, is an important part of ballistic missile defense system. The focal plane is mainly composed of CCD, and its size can reach the micron level, so the pixel is often regarded as point of no area in image postprocessing. The design of traditional tracking methods is based on this, and the observation based on the focal plane is modeled as the azimuth with random noise. However, this modeling is inaccurate. In the context of space-based detection, CCD cannot be simplified as a point, and its size should be considered. And the corresponding observation cannot be treated as azimuth with random noise. In this paper, the observation based on focal plane is modeled as Unambiguously Generated Ambiguous (UGA measurement. The PHD filter algorithm is redesigned and simplified. The simulation results show that the algorithm based on UGA measurement observation model has better tracking effect compared with that based on traditional observation model. This method provides technical support for more accurate target tracking for space-based early warning system.

  8. A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.

    Science.gov (United States)

    Mansisidor, Andres R; Cecere, Germano; Hoersch, Sebastian; Jensen, Morten B; Kawli, Trupti; Kennedy, Lisa M; Chavez, Violeta; Tan, Man-Wah; Lieb, Jason D; Grishok, Alla

    2011-09-01

    Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studying the biological functions of the endogenous RNA interference factor RDE-4 and conserved PHD zinc finger protein ZFP-1 (AF10), which regulate overlapping sets of genes in Caenorhabditis elegans, we identified an important role for these factors in the negative modulation of transcription of the insulin/PI3 signaling-dependent kinase PDK-1. Consistently, increased expression of pdk-1 in zfp-1 and rde-4 mutants contributed to their reduced lifespan and sensitivity to oxidative stress and pathogens due to the reduction in the expression of DAF-16 and SKN-1 targets. We found that the function of ZFP-1 in modulating pdk-1 transcription was important for the extended lifespan of the age-1(hx546) reduction-of-function PI3 kinase mutant, since the lifespan of the age-1; zfp-1 double mutant strain was significantly shorter compared to age-1(hx546). We further demonstrate that overexpression of ZFP-1 caused an increased resistance to oxidative stress in a DAF-16-dependent manner. Our findings suggest that epigenetic regulation of key upstream signaling components in signal transduction pathways through chromatin and RNAi may have a large impact on the outcome of signaling and expression of numerous downstream genes.

  9. Frizzled to finance: one PhD's path from a Drosophila lab to Wall Street.

    Science.gov (United States)

    Taylor, Job

    2016-06-01

    An equity research analyst's job is to determine whether the price of a stock is likely to go up or down. For science-based businesses, particularly biotechnology companies, a PhD in the life sciences can be very helpful in making this determination. I transitioned from a postdoc position to working in equity research. Here I present information on how I made the transition, an overview of the day-to-day activities of an analyst, and thoughts on how to prepare to look for a job in finance. There are significant positives to working on Wall Street, including exposure to cutting-edge clinical/translational research, access to some of the best scientists in the world, a dynamic work environment, and compensation that generally exceeds academic salaries. This comes at the cost of some independence and the satisfaction of being able to call oneself a scientist. © 2016 Taylor. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  10. What Does It Take? Auto/biography as Performative PhD Thesis

    Directory of Open Access Journals (Sweden)

    Sally Berridge

    2008-05-01

    Full Text Available Recently I completed a performative (creative PhD in the School of Creative Communication (now the Faculty of Design and Creative Practice at the University of Canberra, Australia, where such doctorates were established only in 2002. Since I completed in 2006, I have been contemplating some process issues that emerged during my three and a half year's studies. While conferring with fellow students and colleagues at three universities in England, I found that the many of the problems they encountered were similar and so were not due uniquely to the innovative phase that I encountered, but were part of a wider scenario. At my university, the requirements for a creative doctorate are a creative component (equivalent to about 60,000 words and a theoretical component (exegesis of about 30,000 words. The physical outcome of my thesis is two artist's books: one, Tissue, is autobiographical, while questioning the nature of autobiography, memory and identity. The other, Re-Picturing My Life, is the theoretical component, examining several paradigms including issues of methodology; the value of art as research; theories of memory, identity, autobiography, and human interactions with objects. I have placed some of my text/images in this paper to provide a taste of the work in my thesis. My paper reflects on performative work in the context of academic research, and the resilience, determination and sense of humour needed to complete a doctorate successfully in this valuable area of endeavour. URN: urn:nbn:de:0114-fqs0802451

  11. Stepping Stones to Research: Providing Pipelines from Middle School through PhD

    Science.gov (United States)

    Noel-Storr, Jacob; Baum, S. A.; RIT Insight Lab SSR Team; Carlson CenterImaging Science Faculty, Chester F.

    2014-01-01

    We present a decade's worth of strategies designed to promote and provide "Stepping Stones to Research" to provide a realistic pipeline of educational opportunities, with multiple gateways and exit points, for students moving towards STEM careers along the "STEM pipeline". We also illustrate how the Stepping Stones are designed to incidentally co-inside with related external opportunities through which we can also guide and support our mentees on their paths. We present programs such as middle school family science programs, high school research opportunities, high school internships, undergraduate research pathways, research experiences for undergraduates, and other opportunities. We will highlight the presentations being made at this very meeting -- from the first presentation of a high school student, to a dissertation presentation of a PhD graduate -- that have benefited from this stepping stone principle. We also reflect on the essential nature of building a "researcher-trust", even as a young student, of advocates and mentors who can support the continuation of a scientific career.

  12. Shaping the esp curriculum of an english for PhD students program: a colombian case study of questionnaire research

    Directory of Open Access Journals (Sweden)

    Gerriet Janssen

    2012-12-01

    Full Text Available This report presents the findings from an EAP curriculum development project directed towards PhD students at Colombian university.An analysis of this stakeholder group’s learning needs was conducted through questionnaire research, focusing on (a describing students’situated contexts and interests and (b obtaining data contributing towards future program development. Measures of central tendency,dispersion, and internal consistency for each section of the questionnaire are reported. Key results include these students’ strong interest inEAP programming, their language needs and experience regarding their intellectual production, and their perceived importance of differentlanguage sub-skills in both the local and international contexts. The results highlight the importance of continued evaluation cycles and theimportant role EAP coursework has for PhD students today.

  13. Eberhard Widmann (Stefan Meyer Institute, Vienna) and Silke Federmann (Ph.D. Student from Vienna in the CERN-Austrian Ph.D. program) together with a microwave cavity developed by Silke at CERN. The cavity will be used for the first time to look for spin-flip transitions of antihydrogen atoms later this year.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Eberhard Widmann (Stefan Meyer Institute, Vienna) and Silke Federmann (Ph.D. Student from Vienna in the CERN-Austrian Ph.D. program) together with a microwave cavity developed by Silke at CERN. The cavity will be used for the first time to look for spin-flip transitions of antihydrogen atoms later this year.

  14. ChemSession'07 - 4{sup th} Seminary of Warsaw PhD Students in Chemistry. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Dobrowolski, J C [Industrial Chemistry Research Institute, Warsaw (Poland); National Institute of Drugs, Warsaw (Poland); Ostrowski, S [Industrial Chemistry Research Institute, Warsaw (Poland); Madura, I; Sporzynski, A; Szatylowicz, H; Zubrowska, A [Warsaw University of Technology, Warsaw (Poland)

    2007-07-01

    4{sup th} Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2007 participants presented 4 plenary lectures, and 101 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology.

  15. ChemSession'06 - 3{sup rd} Seminary of Warsaw PhD Students in Chemistry. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Zachara, J; Lulinski, S [Warsaw University of Technology, Warsaw (Poland); Dobrowolski, J C [Industrial Chemistry Research Institute, Warsaw (Poland); National Institute of Drugs, Warsaw (Poland); Raczynska, E D [Warsaw University of Life Sciences (SGGW), Warsaw (Poland); Fuks, L [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cyranski, M K; Stepien, B T [University of Warsaw, Warsaw (Poland); Sawicki, M G [Cecylia Plater-Zylberkowna High School, Warsaw (Poland)

    2006-07-01

    3{sup rd} Annual Seminary of Warsaw PhD Students in Chemistry presented the latest achievements in chemistry, obtained in all Warsaw universities and scientific institutes. In 2006 participants presented 4 plenary lectures, and 109 posters. Among others, posters covered four disciplines related to the nuclear sciences: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) isotopic effects in chemistry, and (d) chemical technology.

  16. Simulation Programs for Ph.D. Study of Analysis, Modeling and Optimum Design of Solar Domestic Hot Water Systems

    DEFF Research Database (Denmark)

    Qin, Lin

    1999-01-01

    The design of solar domestic hot water system is a complex process, due to characteristics inherent in solar heating technology. Recently, computer simulation has become a widely used technique to improve the understanding of the thermal processes in such systems. This report presents the detaile...... programs or units that were developed in the Ph.D study of " Analysis, Modeling and Optimum Design of Solar Domestic Hot Water Systems"....

  17. A biographical note on Max Friedrich (1856-1887), Wundt's first PhD student in experimental psychology.

    Science.gov (United States)

    Domanski, Cezary W

    2004-01-01

    This article unveils some previously unknown facts about the short life of Max Friedrich (1856-1887), the author in 1881 of the first PhD dissertation on experimental psychology, written under the supervision of Wilhelm Wundt: "On the Duration of Apperception for Simple and Complex Visual Stimuli." The article describes Friedrich's family background and life, professional career as a teacher, and works in psychology and mathematics. Copyright 2004 Wiley Periodicals, Inc.

  18. A National Survey Examining Manuscript Dissertation Formats Among Nursing PhD Programs in the United States.

    Science.gov (United States)

    Graves, Janessa M; Postma, Julie; Katz, Janet R; Kehoe, Leanne; Swalling, Eileen; Barbosa-Leiker, Celestina

    2018-03-08

    Among research-focused nursing doctoral (PhD) programs in the United States, the traditional dissertation format has recently given way to a series of publication-ready manuscripts, often bookended by introduction and conclusion chapters. To help programs make decisions about the use of these formats, this study undertook a national survey of programs offering PhDs in nursing. The purpose of this study was to explore the advantages and disadvantages of the traditional format versus manuscript option for dissertations among nursing PhD programs in the United States. Cross-sectional census survey of U.S. nursing PhD programs. A web-based survey was administered to all U.S. nursing PhD programs. Respondents indicated formats offered, factors contributing to decisions of which formats to offer, and lessons learned. Descriptive statistics and inductive content analyses were used for analysis. Of 121 eligible institutions, 79 provided eligible responses (66.7%). The majority (59%) offered both formats; 11% offered the manuscript option only, and 24% offered the traditional format only. Faculty support (or lack thereof) contributed to adoption (or not) of the manuscript option. Respondents' approaches to the manuscript option (e.g., number of papers) and advice are summarized. Manuscript option dissertations are commonly offered and provide benefits to students and faculty; however, thoughtful implementation is critical. Programs need to agree upon clear expectations and have graduate school support (e.g., formatting). Faculty need mentorship in advising manuscript option students who choose to use this format, and the time and support. Finally, students need additional writing skills that could be provided through coursework or via individual work with mentors. As nursing education continues to expand further into doctoral research, programs must examine dissertation formats in order to both prepare future nurse scholars and disseminate nursing research that is critical

  19. Cooperation and human development projects as bachelor, master and PhD thesis: evaluating an internship program

    OpenAIRE

    Ferrer Martí, Laia; Garfi, Marianna; Ferrer Martí, Ivet

    2015-01-01

    The Research Group on Cooperation and Human Development (GRECDH) of the Technical University of Catalonia (UPC) has long promoted Bachelor, Master and PhD Theses in the framework of sustainable energy projects in low income countries. In this way, students combine their work at UPC with tasks in these countries. The aim of this paper is to present and evaluate the program through the experience of several students who participated in sustainable energy projects in Central and South America.

  20. Industrial Ph.D. Programs for the Strengthening of the Industry’s Production of Innovation in Colombia

    Directory of Open Access Journals (Sweden)

    Jorge Celis

    2016-09-01

    Full Text Available Today’s firms face a new global economy powered by knowledge rather than physical resources and natural raw materials. Universities are crucial actors in ensuring economic development, not only by training highly qualified human capital, but also by producing new knowledge with innovation potential. University–industry research collaborations (UICs have been increaingly recognized as an innovation mode. Highly qualified people, mainly at Ph.D. level, are fundamental for the increase of the knowledge pool from which firms and society as a whole can benefit in terms of the production of innovation. The demand for more specialized researchers in business/industry has led to new versions of doctoral programs, such as Industrial Ph.D. Programs (IPPs, which are well-established in a number of countries. After using an analytical international and comparative education methodology, we have found that the cooperation with industry to develop Ph.D. programs in Colombia is relatively weak and requires to be enhanced. In this paper, we argue for the alignment of the so-called third academic mission of economic development with the traditional academic missions of teaching and research through the implementation of IPPs as a mechanism for strengthening the innovation process of firms and country’s economic growth.

  1. Using Communicative Action Theory to Analyse Relationships Between Supervisors and Phd Students in a Technical University in Sweden

    Directory of Open Access Journals (Sweden)

    Michael Christie

    2013-04-01

    Full Text Available In this paper the authors use the theory of communicative action (Habermas, 1984-6 to analyse problematic relationships that can occur between supervisors and PhD students, between co-supervisors and between the students themselves. In a situation where power is distributed unequally, instrumental and strategic action on the part of either party can complicate and disturb efficacious relationships. We use Flanagan’s critical incident technique (Flanagan, 1954 to analyse twenty-five incidents that are told from a supervisor perspective and twentyfive from a PhD student perspective. The analysis reveals that a large proportion of incidents involved power struggles. Other categories include lack of professional or emotional support and poor communication. Rational dialogue based on Habermasian principles might have avoided many of these problems. The analysis concludes with some practical suggestions as to how the use of communicative action theory and critical incident technique can improve supervision, supervision training and the PhD process.

  2. The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin

    Science.gov (United States)

    Papait, Roberto; Pistore, Christian; Grazini, Ursula; Babbio, Federica; Cogliati, Sara; Pecoraro, Daniela; Brino, Laurent; Morand, Anne-Laure; Dechampesme, Anne-Marie; Spada, Fabio; Leonhardt, Heinrich; McBlane, Fraser; Oudet, Pierre

    2008-01-01

    Heterochromatic chromosomal regions undergo large-scale reorganization and progressively aggregate, forming chromocenters. These are dynamic structures that rapidly adapt to various stimuli that influence gene expression patterns, cell cycle progression, and differentiation. Np95-ICBP90 (m- and h-UHRF1) is a histone-binding protein expressed only in proliferating cells. During pericentromeric heterochromatin (PH) replication, Np95 specifically relocalizes to chromocenters where it highly concentrates in the replication factories that correspond to less compacted DNA. Np95 recruits HDAC and DNMT1 to PH and depletion of Np95 impairs PH replication. Here we show that Np95 causes large-scale modifications of chromocenters independently from the H3:K9 and H4:K20 trimethylation pathways, from the expression levels of HP1, from DNA methylation and from the cell cycle. The PHD domain is essential to induce this effect. The PHD domain is also required in vitro to increase access of a restriction enzyme to DNA packaged into nucleosomal arrays. We propose that the PHD domain of Np95-ICBP90 contributes to the opening and/or stabilization of dense chromocenter structures to support the recruitment of modifying enzymes, like HDAC and DNMT1, required for the replication and formation of PH. PMID:18508923

  3. Genome-Wide Identification of the PHD-Finger Family Genes and Their Responses to Environmental Stresses in Oryza sativa L.

    Science.gov (United States)

    Sun, Mingzhe; Yang, Junkai; Cui, Na; Zhu, Yanming

    2017-01-01

    The PHD-finger family has been demonstrated to be involved in regulating plant growth and development. However, little information is given for its role in environmental stress responses. Here, we identified a total of 59 PHD family genes in the rice genome. These OsPHDs genes were located on eleven chromosomes and synteny analysis only revealed nine duplicated pairs within the rice PHD family. Phylogenetic analysis of all OsPHDs and PHDs from other species revealed that they could be grouped into two major clusters. Furthermore, OsPHDs were clustered into eight groups and members from different groups displayed a great divergence in terms of gene structure, functional domains and conserved motifs. We also found that with the exception of OsPHD6, all OsPHDs were expressed in at least one of the ten tested tissues and OsPHDs from certain groups were expressed in specific tissues. Moreover, our results also uncovered differential responses of OsPHDs expression to environmental stresses, including ABA (abscisic acid), water deficit, cold and high Cd. By using quantitative real-time PCR, we further confirmed the differential expression of OsPHDs under these stresses. OsPHD1/7/8/13/33 were differentially expressed under water deficit and Cd stresses, while OsPHD5/17 showed altered expression under water deficit and cold stresses. Moreover, OsPHD3/44/28 displayed differential expression under ABA and Cd stresses. In conclusion, our results provide valuable information on the rice PHD family in plant responses to environmental stress, which will be helpful for further characterizing their biological roles in responding to environmental stresses.

  4. English summary of chapters in PhD Thesis 'Landscape transformations. A new paradigm for working with the synergy of physical and abstract landscapes

    DEFF Research Database (Denmark)

    Munck Petersen, Rikke

    2011-01-01

    English summary of chapters in PhD Thesis 'Landscape transformations. A new paradigm for working with the synergy of physical and abstract landscapes in relation to the ICAR-CORA Prize 2011......English summary of chapters in PhD Thesis 'Landscape transformations. A new paradigm for working with the synergy of physical and abstract landscapes in relation to the ICAR-CORA Prize 2011...

  5. QGIS TimeManager and how the QGIS community helped me make a great leap forward in visualizing tracking data for my PhD project

    DEFF Research Database (Denmark)

    Nielsen, Søren Zebitz

    2015-01-01

    This blog post is the story how collaboration with the QGIS developer community made me able to produce some much needed visualizations of pedestrian tracking data for my ongoing PhD project.......This blog post is the story how collaboration with the QGIS developer community made me able to produce some much needed visualizations of pedestrian tracking data for my ongoing PhD project....

  6. Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic-Ischemic Injury in the Neonatal Rat.

    Science.gov (United States)

    Chu, Hannah X; Jones, Nicole M

    2016-03-01

    Hypoxia leads to activation of many cellular adaptive processes which are regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 consists of HIF-1α and HIF-1ß subunits and levels of HIF-1α protein are regulated by HIF prolyl-hydroxylase enzymes (PHD1, 2, 3). The aim of the current study was to investigate the expression of HIF-1α and PHDs at various time points after hypoxia-ischemia (HI), using a neonatal rat model of HI brain injury. Sprague-Dawley rat pups (postnatal day 7) were anaesthetized and underwent right carotid artery occlusion and were then exposed to 6 % oxygen for 2.5 h at 37 °C. HI injured animals demonstrated a significant reduction in the size of the ipsilateral hemisphere, compared to sham controls. Protein analysis using western blotting and enzyme-linked immunosorbent assay showed that 24 h after HI, there was a significant increase in PHD3 protein and an increase of HIF-1α compared to controls. At the 72 h time point, there was a reduction in PHD3 protein, which appeared to relate to cellular loss. There were no changes in PHD1 or PHD2 protein levels after HI when compared to age-matched controls. Further studies are necessary to establish roles for the HIF-1 regulatory enzyme PHD3 in brain injury processes.

  7. To make a kick start together – A PhD course co-developed by librarians and professors

    Directory of Open Access Journals (Sweden)

    Ann-Sofie Zettergren

    2013-12-01

    Full Text Available This paper presents a PhD-course called "Kick start to academic life - Information Management and Publication Process for Social Scientists", a collaboration between the Social Sciences Faculty Library at Lund University and professors at the Faculty. The objective of the course is to provide PhD candidates with generic knowledge about how to effectively conduct their PhD studies when it comes to information management and the publication processes. The course combines an introduction to the process of managing one's need of information as a PhD student, and an introduction to the process of managing the publication of one's results. The librarians have been involved in the development of this PhD course, from the first idea of a course in generic competences and on to the actual implementation. The Faculty of Social Science came up with the idea of a course like this in 2009, and asked two teachers/professors and two librarians to make an outline. We choose to focus on students in the beginning of their PhD studies, who would benefit most from it. We have now run it for 3 years (2010-2012, developed the course as for content and size, from demands from students and faculty as well as from our own experiences. Designing the course together, librarians and professors gained an insight into each other's competences and area of expertise. We used previous experiences from working with PhD students, like the providing of shorter courses, seminars and workshops. We choose a course design mixing lectures and workshops, in order to make the course both theoretical and practical. The course design also helped emphasizing aspects of the subject being discussed. One example is by adding a practical workshop in reference management program given by the librarians just after a lecture given by a professor about how and why academics cite. Another example is when we invite an editor of a high ranked peer-reviewed journal to talk about article submission from

  8. associated with keratitis.

    African Journals Online (AJOL)

    2004-02-23

    Feb 23, 2004 ... offers a reasonable alternative for the treatment of bacterial keratitis. Also, the isolation of ... presence of bacteria on corneal scraping of the eye. (Terry et al. ... lenses, failure to air-dry lens-storage cases or the use of one-step ...

  9. Predictors of High Motivation Score for Performing Research Initiation Fellowship, Master 1, Research Master 2, and PhD Curricula During Medical Studies: A Strobe-Compliant Article.

    Science.gov (United States)

    Feigerlova, Eva; Oussalah, Abderrahim; Fournier, Jean-Paul; Antonelli, Arnaud; Hadjadj, Samy; Marechaud, Richard; Guéant, Jean-Louis; Roblot, Pascal; Braun, Marc

    2016-02-01

    Translational research plays a crucial role in bridging the gap between fundamental and clinical research. The importance of integrating research training into medical education has been emphasized. Predictive factors that help to identify the most motivated medical students to perform academic research are unknown. In a cross-sectional study on a representative sample of 315 medical students, residents and attending physicians, using a comprehensive structured questionnaire we assessed motivations and obstacles to perform academic research curricula (ie, research initiation fellowship, Master 1, Research Master 2, and PhD). Independent predictive factors associated with high "motivation score" (top quartile on motivation score ranging from 0 to 10) to enroll in academic research curricula were derived using multivariate logistic regression analysis. Independent predictors of high motivation score for performing Master 1 curriculum were: "considering that the integration of translational research in medical curriculum is essential" (OR, 3.79; 95% CI, 1.49-9.59; P = 0.005) and "knowledge of at least 2 research units within the university" (OR, 3.60; 95% CI, 2.01-6.47; P motivation score for performing Research Master 2 curriculum were: "attending physician" (OR, 4.60; 95% CI, 1.86-11.37; P = 0.001); "considering that the integration of translational research in medical curriculum is essential" (OR, 4.12; 95% CI, 1.51-11.23; P = 0.006); "knowledge of at least 2 research units within the university" (OR, 3.51; 95% CI, 1.91-6.46; P = 0.0001); and "male gender" (OR, 1.82; 95% CI, 1.02-3.25; P = 0.04). Independent predictors of high motivation score for performing PhD curriculum were: "considering that the integration of translational research in medical curriculum is essential" (OR, 5.94; 95% CI, 2.33-15.19; P = 0.0002) and "knowledge of at least 2 research units within the university" (OR, 2.63; 95% CI, 1.46-4.77; P = 0.001). This is the

  10. MS PHD'S: A Successful Model Promoting Inclusion, Preparation and Engagement of Underrepresented Minorities within the Geosciences Workforce

    Science.gov (United States)

    Padilla, E.; Scott, O.; Strickland, J. T.; Ricciardi, L.; Guzman, W. I.; Braxton, L.; Williamson, V.; Johnson, A.

    2015-12-01

    According to 2014 findings of the National Research Council, geoscience and related industries indicate an anticipated 48,000 blue-collar, scientific, and managerial positions to be filled by underrepresented minority (URM) workers in the next 15 years. An Information Handling Services (IHS) report prepared for the American Petroleum Institute forecasts even greater numbers estimating upward of 408,000 opportunities for URM workers related to growth in accelerated development of oil, gas and petroleum industries. However, many URM students lack the training in both the hard sciences and craft skills necessary to fill these positions. The Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science (MS PHD'S) Professional Development Program uses integrative and holistic strategies to better prepare URM students for entry into all levels of the geoscience workforce. Through a three-phase program of mentoring, community building, networking and professional development activities, MS PHD'S promotes collaboration, critical thinking, and soft skills development for participants. Program activities expose URM students to education, training and real-life geoscience workforce experiences while maintaining a continuity of supportive mentoring and training networks via an active virtual community. MS PHD'S participants report increased self-confidence and self-efficacy in pursuing geoscience workforce goals. To date, the program supports 223 participants of who 57, 21 and 16 have received Doctorate, Masters and Baccalaureate degrees respectively and are currently employed within the geoscience and related industries workforce. The remaining 129 participants are enrolled in undergraduate and graduate programs throughout the U.S. Geographic representation of participants includes 35 states, the District of Columbia, Puerto Rico and two international postdoctoral appointments - one in Saudi Arabia and the other in France.

  11. The impact of teaching experience on interview performance of different candidates of basic medical sciences in PhD admission.

    Science.gov (United States)

    Mehridehnavi, Alireza

    2015-01-01

    Admission includes written and interview at universities belonging to the ministry of the health and medical education of Iran at PhD level. In the present work, it was tried to find out the likelihood of interview performance of different candidates with their teaching experience in Iranian national medical PhD admission in the year 1386-87. In this study, applicants' exam results were extracted from their score workbooks for year 86-87. PhD applicants' categories were public (ordinary) and employed lecturers. Invited numbers of candidates for interview were 556 from 29 different fields of study. As the number of written subjects were not the same within different fields of study, at the first, each group score distribution were normalized to one and then combined together for final consideration. Accept and reject percentage within public applicants were 45.1 and 54.9, respectively, while the accept percentage within lecturer applicants was 66 and the reject was 34 respectively. Scores of all 29 groups were combined after normalization. The overall performance including test plus interview for public and lecturers were 1.02 ± 0.12 and 0.95 ± 0.1, respectively. The average and standard deviation of test exam of public and lecturer were 1.04 ± 0.16 and 0.91 ± 0.12, respectively. The average and standard deviation of interview exam of public applicants and lecturers applicants were 0.98 ± 0.18 and 1.04 ± 0.17, respectively. As results show, the interview performance of lecturers is better than public applicants. Unbalanced acceptance rate amongst lecturers was increased due to the hold of reservation toward interview and due to their higher results gain during interview. If the test performance was a reliable measure for viability of applicant, this reservation would change the acceptance rate close to balance.

  12. MS PHD'S PDP: Vision, Design, Implementation, and Outcomes of a Minority-Focused Earth System Sciences Program

    Science.gov (United States)

    Habtes, S. Y.; Mayo, M.; Ithier-Guzman, W.; Pyrtle, A. J.; Williamson Whitney, V.

    2007-05-01

    As minorities are predicted to comprise at least 33% of the US population by the year 2010, their representation in the STEM fields, including the ocean sciences, is still poorly established. In order to advance the goal of better decision making, the Ocean Sciences community must achieve greater levels of diversity in membership. To achieve this objective of greater diversity in the sciences, the Minorities Striving and Pursuing Higher Degrees of Success in Earth System Science® Professional Development Program (MS PHD'S PDP), which was launched in 2003, is supported via grants from NASA's Office of Earth Science, and NSF's Directorate for Geosciences. The MS PHD'S PDP is designed to provide professional and mentoring experiences that facilitate the advancement of minorities committed to achieving outstanding Earth System Science careers. The MS PHD'S PDP is structured in three phases, connected by engagement in a virtual community, continuous peer and mentor to mentee interactions, and the professional support necessary for ensuring the educational success of the student participants. Since the pilot program in 2003, the MSPHD'S PDP, housed at the University of South Florida's College of Marine Science, has produced 4 cohorts of students. Seventy-five have completed the program; of those 6 have earned their doctoral degrees. Of the 45 current participants 10 are graduate students in Marine Science and 15 are still undergraduates, the remaining 10 participants are graduate students in other STEM fields. Since the implementation of the MSPHD'S PDP a total of 87 students and 33 scientist mentors have become part of the MSPHD'S virtual community, helping to improve the learning environment for current and future participants as well as build a community of minority students that encourages each other to pursue their academic degrees.

  13. Simulation programs for ph.D. study of analysis, modeling and optimum design of solar domestic hot water systems

    Energy Technology Data Exchange (ETDEWEB)

    Lin Qin

    1998-12-31

    The design of solar domestic hot water (DHW) systems is a complex process, due to characteristics inherent in the solar heating technology. Recently, computer simulation has become a widely used technique to improve the understanding of the thermal processes in such systems. One of the main objects of the Ph.D. study of `Analysis, Modelling and optimum Design of Solar Domestic Hot Water Systems` is to develop and verify programs for carrying out the simulation and evaluation of the dynamic performance of solar DHW systems. During this study, simulation programs for hot water distribution networks and for certain types of solar DHW systems were developed. (au)

  14. Something going on in Milan: a review of the 4th International PhD Student Cancer Conference.

    Science.gov (United States)

    Segré, C

    2010-01-01

    The 4th International PhD Student Cancer Conference was held at the IFOM-IEO-Campus in Milan from 19-21 May 2010 http://www.semm.it/events_researchPast.phpThe Conference covered many topics related to cancer, from basic biology to clinical aspects of the disease. All attendees presented their research, by either giving a talk or presenting a poster. This conference is an opportunity to introduce PhD students to top cancer research institutes across Europe.THE CORE PARTICIPANTING INSTITUTES INCLUDED: European School of Molecular Medicine (SEMM)-IFOM-IEO Campus, MilanBeatson Institute for Cancer Research (BICR), GlasgowCambridge Research Institute (CRI), Cambridge, UKMRC Gray Institute of Radiation Biology (GIROB), OxfordLondon Research Institute (LRI), LondonPaterson Institute for Cancer Research (PICR), ManchesterThe Netherlands Cancer Institute (NKI), Amsterdam'You organizers have crushed all my prejudices towards Italians. Congratulations, I enjoyed the conference immensely!' Even if it might have sounded like rudeness for sure this was supposed to be a genuine compliment (at least, that's how we took it), also considering that it was told by a guy who himself was the fusion of two usually antithetical concepts: fashion style and English nationality.The year 2010 has marked an important event for Italian research in the international scientific panorama: the European School of Molecular Medicine (SEMM) had the honour to host the 4th International PhD Student Cancer Conference, which was held from 19-21 May 2010 at the IFOM-IEO-Campus (http://www.semm.it/events_researchPast.php) in Milan.The conference was attended by more than one hundred students, coming from a selection of cutting edge European institutes devoted to cancer research. The rationale behind it is the promotion of cooperation among young scientists across Europe to debate about science and to exchange ideas and experiences. But that is not all, it is also designed for PhD students to get in touch

  15. The experience of international nursing students studying for a PhD in the U.K: A qualitative study.

    Science.gov (United States)

    Evans, Catrin; Stevenson, Keith

    2011-06-13

    Educating nurses to doctoral level is an important means of developing nursing capacity globally. There is an international shortage of doctoral nursing programmes, hence many nurses seek their doctorates overseas. The UK is a key provider of doctoral education for international nursing students, however, very little is known about international doctoral nursing students' learning experiences during their doctoral study. This paper reports on a national study that sought to investigate the learning expectations and experiences of overseas doctoral nursing students in the UK. Semi-structured qualitative interviews were conducted in 2008/09 with 17 international doctoral nursing students representing 9 different countries from 6 different UK universities. Data were analysed thematically. All 17 interviewees were enrolled on 'traditional' 3 year PhD programmes and the majority (15/17) planned to work in higher education institutions back in their home country upon graduation. Studying for a UK PhD involved a number of significant transitions, including adjusting to a new country/culture, to new pedagogical approaches and, in some cases, to learning in a second language. Many students had expected a more structured programme of study, with a stronger emphasis on professional nursing issues as well as research - akin to the professional doctorate. Students did not always feel well integrated into their department's wider research environment, and wanted more opportunities to network with their UK peers. A good supervision relationship was perceived as the most critical element of support in a doctoral programme, but good relationships were sometimes difficult to attain due to differences in student/supervisor expectations and in approaches to supervision. The PhD was perceived as a difficult and stressful journey, but those nearing the end reflected positively on it as a life changing experience in which they had developed key professional and personal skills. Doctoral

  16. The experience of international nursing students studying for a PhD in the U.K: A qualitative study

    Directory of Open Access Journals (Sweden)

    Stevenson Keith

    2011-06-01

    Full Text Available Abstract Background Educating nurses to doctoral level is an important means of developing nursing capacity globally. There is an international shortage of doctoral nursing programmes, hence many nurses seek their doctorates overseas. The UK is a key provider of doctoral education for international nursing students, however, very little is known about international doctoral nursing students' learning experiences during their doctoral study. This paper reports on a national study that sought to investigate the learning expectations and experiences of overseas doctoral nursing students in the UK. Methods Semi-structured qualitative interviews were conducted in 2008/09 with 17 international doctoral nursing students representing 9 different countries from 6 different UK universities. Data were analysed thematically. All 17 interviewees were enrolled on 'traditional' 3 year PhD programmes and the majority (15/17 planned to work in higher education institutions back in their home country upon graduation. Results Studying for a UK PhD involved a number of significant transitions, including adjusting to a new country/culture, to new pedagogical approaches and, in some cases, to learning in a second language. Many students had expected a more structured programme of study, with a stronger emphasis on professional nursing issues as well as research - akin to the professional doctorate. Students did not always feel well integrated into their department's wider research environment, and wanted more opportunities to network with their UK peers. A good supervision relationship was perceived as the most critical element of support in a doctoral programme, but good relationships were sometimes difficult to attain due to differences in student/supervisor expectations and in approaches to supervision. The PhD was perceived as a difficult and stressful journey, but those nearing the end reflected positively on it as a life changing experience in which they had

  17. Identifying most important skills for PhD students in Food Science and Technology: a comparison between industry and academic stakeholders

    Directory of Open Access Journals (Sweden)

    Chelo González-Martínez

    2015-10-01

    Full Text Available Nowadays, there is an increasing need of new skills for PhD students to face the future labour market prospects. PhD graduates must have qualities attractive not only in academia but also outside, in both manufacture and service-oriented enterprises, in small innovative companies, and in the civil services and public administration, among others. To know what the needs of these future employees are, is of great importance to be able to improve their personal and academic formation. The aim of this work was, in the framework of the EC-funded ISEKI_Food 4 network, to evaluate the most desirable specific and soft skills that PhD students should acquire by the end of their doctoral studies. To this aim, several surveys were conducted and sent to the different stakeholders (academia and food industry partners in order to collect the information needed. Results showed that competences related to research skills and techniques, research management, personal effectiveness and communication skills were considered to be the most valuable skills to be acquired by our PhD students to meet the future needs of the labour market.  The importance of these skills was appreciated differently, depending on the stakeholder. To sum up, some recommendations to integrate such valuable skills into the curricula of the PhD student are given.

  18. Harnessing the power of communities: career networking strategies for bioscience PhD students and postdoctoral researchers.

    Science.gov (United States)

    Blackford, Sarah

    2018-04-01

    With an ever more competitive global labour market, coupled with an ever-increasing population of PhD-qualified graduates, the ability to communicate effectively and build strategic connections with others can be advantageous in the job-search process. Whether in pursuit of a tenure-track or non-academic position, many postdoctoral researchers and PhD students will benefit from networking as early as possible to enhance their career prospects. Sometimes viewed cynically as 'using people' or dismissed as 'the old boy network,' the ability to make meaningful connections and build relationships can be more valuable than other job-related skills in order to gain entry to, and progress within, many professions. This mini-review highlights the positive influence of networking and how bioscience PhD students and postdoctoral researchers can harness the power of communities to achieve career success. It is argued that those who make connections and promote personal patronage through networking can gain an advantage over their contemporaries. A summary of key theories and research studies that underpin the practice of networking provides credence to these assertions, which are further substantiated with examples pertinent to the academic community. Although primarily focussed on the biosciences, much of the content is applicable to other scientists at a similar career stage.

  19. Spanish production of PhD Thesis in the field of guidance on TESEO database (2001-2012

    Directory of Open Access Journals (Sweden)

    Ferreira-Villa, Camino

    2013-04-01

    Full Text Available The objective of this research is to analyse the scientific production in PhD Thesis about guidance in Spain from 2001 to 2012. The data have been recollected on the TESEO database belonging to the Ministry of Education, Culture and Sport. It has realized a content analysis of the titles, keywords and abstracts and it has assessed of them their productivity, the general and methodological features and the subjects that have been studied. It has been obtained ninety PhD Thesis in relation to the field of guidance over the last ten years that have studied mainly curriculum and career development. El objetivo de este estudio es analizar la producción científica en Tesis Doctorales sobre orientación en España entre 2001 y 2012. Los datos han sido recogidos a través de la Base de datos TESEO del Ministerio de Educación, Cultura y Deporte. Se ha realizado un análisis de contenido de los títulos, descriptores y resúmenes, valorando la productividad del área, las principales características generales y metodológicas y las temáticas estudiadas. Se han obtenido noventa Tesis Doctorales relacionadas con el ámbito de la orientación en los últimos diez años que han estudiado principalmente aspectos sobre el currículum y el desarrollo vocacional.

  20. Preparing MD-PhD students for clinical rotations: navigating the interface between PhD and MD training.

    Science.gov (United States)

    Goldberg, Charles; Insel, Paul A

    2013-06-01

    Many aspects of MD-PhD training are not optimally designed to prepare students for their future roles as translational clinician-scientists. The transition between PhD research efforts and clinical rotations is one hurdle that must be overcome. MD-PhD students have deficits in clinical skills compared with those of their MD-only colleagues at the time of this transition. Reimmersion programs (RPs) targeted to MD-PhD students have the potential to help them navigate this transition.The authors draw on their experience creating and implementing an RP that incorporates multiple types of activities (clinical exam review, objective structured clinical examination, and supervised practice in patient care settings) designed to enhance the participants' skills and readiness for clinical efforts. On the basis of this experience, they note that MD-PhD students' time away from the clinical environment negatively affects their clinical skills, causing them to feel underprepared for clinical rotations. The authors argue that participation in an RP can help students feel more comfortable speaking with and examining patients and decrease their anxiety regarding clinical encounters. The authors propose that RPs can have positive outcomes for improving the transition from PhD to clinical MD training in dual-degree programs. Identifying and addressing this and other transitions need to be considered to improve the educational experience of MD-PhD students.

  1. Too Many PhD Graduates or Too Few Academic Job Openings: The Basic Reproductive Number R0 in Academia.

    Science.gov (United States)

    Larson, Richard C; Ghaffarzadegan, Navid; Xue, Yi

    2014-01-01

    The academic job market has become increasingly competitive for PhD graduates. In this note, we ask the basic question of 'Are we producing more PhDs than needed?' We take a systems approach and offer a 'birth rate' perspective: professors graduate PhDs who later become professors themselves, an analogue to how a population grows. We show that the reproduction rate in academia is very high. For example, in engineering, a professor in the US graduates 7.8 new PhDs during his/her whole career on average, and only one of these graduates can replace the professor's position. This implies that in a steady state, only 12.8% of PhD graduates can attain academic positions in the USA. The key insight is that the system in many places is saturated, far beyond capacity to absorb new PhDs in academia at the rates that they are being produced. Based on the analysis, we discuss policy implications.

  2. Comparison of Automated and Manual Recording of Brief Episodes of Intracranial Hypertension and Cerebral Hypoperfusion and Their Association with Outcome After Severe Traumatic Brain Injury

    Science.gov (United States)

    2017-03-01

    which could limit our ability to evaluate the difference between EVD ICP and IPM ICP. Second, due to the complexity of the human brain and our...quartile 24.8 years and third quartile 49.3 years. There were 68 males and 13 females in this study group. In terms of the severity, those patients...Hypoperfusion and Their Association with Outcome After Severe Traumatic Brain Injury Peter Hu, PhD; Yao Li, MS; Shiming Yang, PhD; Catriona

  3. A study of quadrupole dynamics: quantification of classical motion chaos, and new features of the coherent states model. Resume of Ph.D thesis

    International Nuclear Information System (INIS)

    Baran, V.

    1995-01-01

    This resume of the Ph.D. thesis has three main parts. In the first part a fourth order quadrupole boson Hamiltonian is semi classically treated through a time-dependent variational principle (TDVP), the variational states being of coherent type for the boson operators b 20 + and 1/√2 (b 22 + + b 2-2 + ). The static ground state is studied as a function of the parameters involved in the model Hamiltonian. Linearizing the classical equations of motion one obtains the RPA approach for the many boson correlations. There are two RPA roots which describe the beta and gamma vibrations, respectively. Several quantization procedures for both small and large amplitude regimes are discussed. The quantized Hamiltonians are compared with some others which were previously obtained by using different methods. A special attention is paid to the quantal states associated to some of the peaks appearing in the Fourier spectrum of the classical action density. Some of the quantal states exhibit a pronounced anharmonic structure. Therefore the procedure may be used for a unified description of small and large amplitude regimes. In the next part the semiclassical foundations of the Coherent State Model are established using the formalism elaborated in the previous section. In the third part the semiclassical treatment through a time-dependent variational principle (TDVP) of the fourth order quadrupole boson Hamiltonian H is continued. In the parameter space of H there are regions, conventionally called as 'nuclear phases', determining specific static properties. Several ground states corresponding to different equilibrium shapes are found as static solutions of classical equations of motion. The non-integrable system may follow a chaotic trajectory. The mechanism of destroying the tori bearing regular orbits and the onset of chaos may depend on nuclear phase. The regular and chaotic motions are analyzed in terms of Poincare sections and Lyapunov largest exponent. Specific features of

  4. GRANTS FOR PH.D. STUDENTS ON VSB‐TECHNICAL UNIVERSITY OF OSTRAVA IN THE CZECH REPUBLIC

    Directory of Open Access Journals (Sweden)

    Pavla FOITOVÁ DERNEROVÁ

    2013-07-01

    Full Text Available Projects and grants are unique for development of science and research. For many people it is only source of money for their research. Particularly on universities the projects expanded. From this reason the participation of Ph.D. students in the Student Grant Competition is the best start in this field. Paper discusses in its first part how the Student Grant Competition takes its place on Technical University of Ostrava. Focuses on difficulties with submission of the application, explain process of whole project evaluation and states total amounts acquired from the Ministry of Education, Youth and Sports for Student Grand Competitions since 2010. Second part of this paper directly shows concrete project for “Research of utilization of mining waste in chosen localities.” In the paper is described subject of the research, concrete goals of project, timetable. It is stated the preliminary budget of project and actual progress in the project.

  5. ChemSession'09 - 6. Warsaw Seminar of the PhD Students in Chemistry - Abstracts; ChemSession'09 - 6. Warszawskie Seminarium Doktorantow Chemikow - Streszczenia

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    Book of Abstracts contains short descriptions of presentations 3 lectures and 105 posters presented during ChemSession'09 - 6{sup th} Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found.

  6. Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US

    Science.gov (United States)

    Gibbs, Kenneth D; Basson, Jacob; Xierali, Imam M; Broniatowski, David A

    2016-01-01

    Faculty diversity is a longstanding challenge in the US. However, we lack a quantitative and systemic understanding of how the career transitions into assistant professor positions of PhD scientists from underrepresented minority (URM) and well-represented (WR) racial/ethnic backgrounds compare. Between 1980 and 2013, the number of PhD graduates from URM backgrounds increased by a factor of 9.3, compared with a 2.6-fold increase in the number of PhD graduates from WR groups. However, the number of scientists from URM backgrounds hired as assistant professors in medical school basic science departments was not related to the number of potential candidates (R2=0.12, p>0.07), whereas there was a strong correlation between these two numbers for scientists from WR backgrounds (R2=0.48, pprofessors and posited no hiring discrimination. Simulations show that, given current transition rates of scientists from URM backgrounds to faculty positions, faculty diversity would not increase significantly through the year 2080 even in the context of an exponential growth in the population of PhD graduates from URM backgrounds, or significant increases in the number of faculty positions. Instead, the simulations showed that diversity increased as more postdoctoral candidates from URM backgrounds transitioned onto the market and were hired. DOI: http://dx.doi.org/10.7554/eLife.21393.001 PMID:27852433

  7. Toward an Evaluation Framework for Doctoral Education in Social Work: A 10-Year Retrospective of One PhD Program's Assessment Experiences

    Science.gov (United States)

    Bentley, Kia J.

    2013-01-01

    This article presents a framework for evaluation in social work doctoral education and details 10 years of successes and challenges in one PhD program's use of the framework, including planning and implementing specific assessment activities around student learning outcomes and larger program goals. The article argues that a range of…

  8. Implementation of an Education-Focused PhD Program in Anatomy and Cell Biology at Indiana University: Lessons Learned and Future Challenges

    Science.gov (United States)

    Brokaw, James J.; O'Loughlin, Valerie D.

    2015-01-01

    In 2008, the Indiana University School of Medicine, in collaboration with the School of Education, admitted its first student to a newly approved PhD program in Anatomy and Cell Biology focusing on educational research rather than biomedical research. The goal of the program is twofold: (1) to provide students with extensive training in all of the…

  9. Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger

    Institute of Scientific and Technical Information of China (English)

    Chengkun Wang; Jie Shen; Zhongzheng Yang; Ping Chen; Bin Zhao; Wei Hu; Wenxian Lan

    2011-01-01

    Dear Editor,We report two NMR complex structures of PHDUHRF1 binding to unmodified or K9 trimethylated histone tails,which clarify a controversy regarding how the binding of UHRF1 to H3 tails is mediated.Based on our structures,H3R2,not H3K9,mediates PHD binding.

  10. Queueing systems with heavy tails (Summary of Ph.D. thesis on the occasion of receiving the Gijs de Leve prize)

    NARCIS (Netherlands)

    Zwart, A.P.

    2003-01-01

    This article gives a short summary of my PhD thesis Queueing Systems with Heavy-tails, winner of the Gijs De Leve prize for the best Dutch thesis in operations research in the period 2000-2002. Apart from the Gijs de Leve prize, this thesis also received the ASML prize, for best thesis in Ihe

  11. Revealing Future Research Capacity from an Analysis of a National Database of Discipline-Coded Australian PhD Thesis Records

    Science.gov (United States)

    Pittayachawan, Siddhi; Macauley, Peter; Evans, Terry

    2016-01-01

    This article reports how statistical analyses of PhD thesis records can reveal future research capacities for disciplines beyond their primary fields. The previous research showed that most theses contributed to and/or used methodologies from more than one discipline. In Australia, there was a concern for declining mathematical teaching and…

  12. ChemSession'08 - 5. Warsaw Seminar of the PhD Students in Chemistry - Abstracts; ChemSession'08 - 5. Warszawskie Seminarium Doktorantow Chemikow - Streszczenia

    Energy Technology Data Exchange (ETDEWEB)

    Madura, I [ed.

    2008-07-01

    Book of Abstracts consists of short descriptions of presentations: 5 lectures and 127 posters presented during ChemSession'08 - 5{sup th} Warsaw Seminar of the PhD Students in Chemistry. Several posters were devoted to the radiochemistry, radiochemical analysis, radiation chemistry and radiobiology. Some posters on the material science dealing with materials important to nuclear sciences can be also found.

  13. The Bachelor’s to PhD STEM Pipeline No Longer Leaks More Women Than Men: A 30-Year Analysis

    Directory of Open Access Journals (Sweden)

    David I. Miller

    2015-02-01

    Full Text Available For three decades, research and public discourse about women’s underrepresentation in academic science have often focused on the leaky pipeline metaphor. According to this metaphor, women are more likely than men to leave science at multiple points from the beginning of college through academic tenure. We used retrospective longitudinal methods to investigate how accurately this metaphor has described the bachelor’s to PhD pipeline in science, technology, engineering, and mathematics (STEM fields in the United States (U.S. since the 1970s. Among STEM bachelor’s degree earners in the 1970s and 1980s, women were less likely than men to later earn a STEM PhD. However, this gender difference closed in the 1990s. Qualitatively similar trends were found across STEM disciplines. The leaky pipeline metaphor therefore partially explains historical gender differences in the U.S., but no longer describes current gender differences in the bachelor’s to PhD transition in STEM. Our results help constrain theories of how various factors contribute to women’s underrepresentation in STEM. Overall, these results point to the need to understand gender differences at the bachelor’s level and below to understand women’s representation in STEM at the PhD level and above.

  14. The Linguistic Memory of Composition and the Rhetoric and Composition PhD: Forgetting (and Remembering) Language and Language Difference in Doctoral Curricula

    Science.gov (United States)

    Kilfoil, Carrie Byars

    2017-01-01

    This article analyzes the decline of linguistics in rhetoric and composition PhD programs in terms of the "linguistic memory" (Trimbur) of composition. Since the field of linguistics once offered the primary means for composition to address the structural, psychological, sociohistorical, and cultural dimensions of language in student…

  15. The Role of Gender in the Employment, Career Perception and Research Performance of Recent PhD Graduates from Dutch Universities.

    Science.gov (United States)

    Waaijer, Cathelijn J F; Sonneveld, Hans; Buitendijk, Simone E; van Bochove, Cornelis A; van der Weijden, Inge C M

    2016-01-01

    Recent decades have seen a sharp increase in the number of female PhD graduates in the Netherlands. Currently, the share of females among newly graduated PhDs is almost on par with that of males. A considerable body of scientific studies has investigated the role of gender in the academic workplace. However, the role of gender in the careers of all PhD graduates, including those outside academia, has been studied less. In this study, we investigate gender differences in type of job, occupation, career perception and research performance of recent PhDs. The study is based on a survey of persons who obtained a PhD from one of five Dutch universities between 2008 and early 2012. We show that gender differences in post-PhD careers are non-existent in some aspects studied, but there are small differences in other aspects, such as sector of employment, type of contract, involvement in teaching and management, and career perception. In contrast, male and female PhDs differ sharply on two factors. The first is field of PhD, females being heavily underrepresented in engineering and the natural sciences. The second is part-time employment, females being much more likely to work part-time than males, especially if they work in the Netherlands. In later career stages, the combination of the small and large differences can be presumed to affect the career progression of female PhDs through cumulative disadvantage.

  16. The Motivation and Identity Challenges for PhD Holders in the Transition to Science and Mathematics Teaching in Secondary Education: A Pilot Study

    Science.gov (United States)

    Whannell, Robert; Allen, Bill

    2014-01-01

    Australian secondary education has endured a chronic shortage of qualified mathematics and science teachers for a number of years, particularly in rural and remote areas. A longitudinal research project examining the capacity for the holders of PhD level qualifications in mathematics and science to be utilised as one means of addressing this…

  17. Does working with industry come at a price? : a study of doctoral candidates' performance in collaborative vs. non-collaborative PhD projects

    NARCIS (Netherlands)

    Salimi, N.; Bekkers, R.N.A.; Frenken, K.

    2014-01-01

    The increasing involvement of industry in academic research raised concerns whether university-industry projects actually meet the same academic standards as university projects in-house. Looking at the academic output and impact of collaborative versus non-collaborative Ph.D. projects at Eindhoven

  18. Scaling up nurse education: An evaluation of a national PhD capacity development programme in South Africa, in the context of the global shortage of nursing graduates.

    Science.gov (United States)

    Comiskey, Catherine M; Matthews, Anne; Williamson, Charmaine; Bruce, Judith; Mulaudzi, Mavis; Klopper, Hester

    2015-05-01

    The global shortage of nursing professionals educated at baccalaureate level and beyond has been highlighted. Within America, services are preparing to treat an additional 32 million individuals under the Health Reform Bill. Within South Africa nursing education outputs do not meet demands. Countries are addressing these shortages by developing advanced nurse roles which require research degrees. To evaluate a national PhD programme within the context of a nurse education strategy and a national health insurance plan. A comparative effectiveness research design was employed. The setting was in South Africa between 2011 and 2013, a county with 51.7 million inhabitants. Participants included PhD candidates, programme facilitators, supervisors and key stakeholders. Data from a one day workshop was analysed using an inductive thematic analysis. Three years of evaluation reports were analysed. A mapping of the alignment of the PhD topics with healthcare priorities, and a comparison of the development of nurse education, of the national and international funder were conducted. The evaluation reports rated the programme highly. Three themes were identified from the workshop. These were, "support" with the sub-themes of burden, leveraging and a physical supportive place; "planning" with the sub-themes of the national context and practice, and "quality" with the sub-themes of processes and monitoring and evaluation. The mapping of PhD topics revealed that research was in line with development priorities. However, further investment and infrastructural changes were necessary to sustain the programme and its impact. To address sustainability and capacity in nations scaling up nurse education and healthcare insurance, it was recommended that top-up degrees for diploma educated nurses be developed along with, the implementation of a national nursing strategy for PhD and post-doctoral training encompassing clinical practice implementation and collaboration. Copyright © 2015

  19. Ann O'Mara, PhD, RN, MPH | Division of Cancer Prevention

    Science.gov (United States)

    Dr. Ann O'Mara is Head of Palliative Research in the NCI Division of Cancer Prevention. She manages a portfolio of symptom management and palliative and end-of-life care research projects. The majority of these projects focus on the more common morbidities associated with cancer and its treatment, e.g., pain, chemotherapy induced neuropathy, fatigue, sleep disturbances, and

  20. Models for Theory-Based M.A. and Ph.D. Programs.

    Science.gov (United States)

    Botan, Carl; Vasquez, Gabriel

    1999-01-01

    Presents work accomplished at the 1998 National Communication Association Summer Conference. Outlines reasons for theory-based education in public relations. Presents an integrated model of student outcomes, curriculum, pedagogy, and assessment for theory-based master's and doctoral programs, including assumptions made and rationale for such…

  1. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Energy Technology Data Exchange (ETDEWEB)

    Chardonnet, Pascal [Coordinator IRAP PhD EMJD, Université de Nice 28, avenue Valrose 06103 Nice (France); LAPTh, Université de Savoie, CNRS, B.P. 110, Annecy-le-Vieux F-74941 (France); ICRANet, Piazza della Repubblica 10, 65122 Pescara (Italy); Department for Theoretical Nuclear Physics, National Research Nuclear University Moscow Engineering Physics Institute, MEPhI, Moscow (Russian Federation)

    2015-12-17

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d’Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet

  2. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    International Nuclear Information System (INIS)

    Chardonnet, Pascal

    2015-01-01

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d’Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet

  3. Artium mater in relativistic astrophysics : New perspectives for a European-Latin American PhD program

    Science.gov (United States)

    Chardonnet, Pascal

    2015-12-01

    Following the successful scientific space missions by the European Space Agency (ESA) and the European Southern Observatory (ESO) in Chile, as well as the high-energy particle activities at CERN in Genve, we have created a Ph.D. program dedicated to the formation of scientists in the field of relativistic astrophysics. The students of such a program will lead the theoretical developments of one of the most active fields of research, based on the above observational and experimental facilities. This program needs expertise in the most advanced topics of mathematical and theoretical physics, and in relativistic field theories. It requires the ability to model the observational data received from the above facilities, as well as all the basic knowledge in astronomy, astrophysics and cosmology. This activity is necessarily international, no single university can cover the broad expertises. From this, the proposed program of the IRAP Ph.D., in one of the youngest and most dynamical French universities, pole of research and teaching in the Euro-Mediterranean region (PRES): the University of Nice. It benefits from the presence of the astrophysics research institute of Observatoire de la Cte d'Azur involved in relativistic and non-photonic astrophysics. The participation of the Freie Universitaet Berlin, Oldenburg and Bremen Universities and of the Einstein Institute in Potsdam offers the possibility of teaching in relativistic field theories at the highest level. The University of Savoy offers the link to the particle physics at CERN. The activities at the University of Rome, at Stockholm University and at ICRANet offer teaching programs in all the fields of relativistic astrophysics, including cosmology, the physics of gravitational collapse, gamma-ray bursts, and black hole physics. Finally, the University of Ferrara will be present with lectures and researches in the topics they have pioneered such as x-ray astrophysics and observational cosmology. Through ICRANet the

  4. An Adaptive Technique for a Redundant-Sensor Navigation System. Ph.D. Thesis

    Science.gov (United States)

    Chien, T. T.

    1972-01-01

    An on-line adaptive technique is developed to provide a self-contained redundant-sensor navigation system with a capability to utilize its full potentiality in reliability and performance. The gyro navigation system is modeled as a Gauss-Markov process, with degradation modes defined as changes in characteristics specified by parameters associated with the model. The adaptive system is formulated as a multistage stochastic process: (1) a detection system, (2) an identification system and (3) a compensation system. It is shown that the sufficient statistics for the partially observable process in the detection and identification system is the posterior measure of the state of degradation, conditioned on the measurement history.

  5. Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon.

    Science.gov (United States)

    Chan, Wai Ting; Yeo, Chew Chieng; Sadowy, Ewa; Espinosa, Manuel

    2014-01-01

    Bacterial toxin-antitoxin (TAs) loci usually consist of two genes organized as an operon, where their products are bound together and inert under normal conditions. However, under stressful circumstances the antitoxin, which is more labile, will be degraded more rapidly, thereby unleashing its cognate toxin to act on the cell. This, in turn, causes cell stasis or cell death, depending on the type of TAs and/or time of toxin exposure. Previously based on in silico analyses, we proposed that Streptococcus pneumoniae, a pathogenic Gram-positive bacterium, may harbor between 4 and 10 putative TA loci depending on the strains. Here we have chosen the pneumococcal strain Hungary(19A)-6 which contains all possible 10 TA loci. In addition to the three well-characterized operons, namely relBE2, yefM-yoeB, and pezAT, we show here the functionality of a fourth operon that encodes the pneumococcal equivalent of the phd-doc TA. Transcriptional fusions with gene encoding Green Fluorescent Protein showed that the promoter was slightly repressed by the Phd antitoxin, and exhibited almost background values when both Phd-Doc were expressed together. These findings demonstrate that phd-doc shows the negative self-regulatory features typical for an authentic TA. Further, we also show that the previously proposed TAs XreA-Ant and Bro-XreB, although they exhibit a genetic organization resembling those of typical TAs, did not appear to confer a functional behavior corresponding to bona fide TAs. In addition, we have also discovered new interesting bioinformatics results for the known pneumococcal TAs RelBE2 and PezAT. A global analysis of the four identified toxins-antitoxins in the pneumococcal genomes (PezAT, RelBE2, YefM-YoeB, and Phd-Doc) showed that RelBE2 and Phd-Doc are the most conserved ones. Further, there was good correlation among TA types, clonal complexes and sequence types in the 48 pneumococcal strains analyzed.

  6. Outcomes assessment of science & engineering doctor of philosophy (Ph.D.) programs: An exploratory study of prospective influencers in distinguished graduate placement

    Science.gov (United States)

    Williamson, Louise M.

    This exploratory study was an investigation of the mission and emphases of twenty-two science & engineering doctor of philosophy (Ph.D.) programs in ten fields of study at nine public research universities in the United States and the corresponding influence those factors impose on placement of Ph.D. graduates of those programs into academic program settings. Ph.D. program chairs participated via protocol to provide descriptive, statistical, and experiential details of their Ph.D. programs and offered insight on current conditions for academic placement opportunities. The quantitative analysis served as the basis of examination of influencers in graduate placement for those Ph.D. programs that are informed about placement activity of their graduates. Among the nine tested hypotheses there were no statistically significant findings. The qualitative expressions of this study---those found in the confounding variables, the limitations of the study, those questions that elicited opinions and further discussion and follow-up queries with program chairs---added most meaningfully, however, to the study in that they served as a gauge of the implications of neglect for those Ph.D. programs that remain uninformed about their graduate placement activity. Central to the findings of this study was that one compelling fact remains the same. Denecke, Director of Best Practice at the Council of Graduate Schools, pointed out years ago that just as "we know very little about why those who finish and why those who leave do so, we also know surprisingly little about where students go after their degrees...we therefore have little information about how effective doctoral programs are in preparing doctorates for short- and long-term career success." The fact remains that the effectiveness of doctoral programs in the context of career success is just as uncertain today. A serious admonition is that one-half of those programs that participated in this study remain uninformed about the

  7. Regulation of IGF binding protein proteolysis by pregnancy-associated plasma protein-ARegulation of IGF binding protein proteolysis by pregnancy-associated plasma protein-A

    DEFF Research Database (Denmark)

    Gaidamauskas, Ervinas

    During his PhD studies, Ervinas Gaidamauskas researched the proteins pregnancy-associated plasma protein-A (PAPP-A) and its homologue PAPP-A2 in vitro. As suggested by its name, PAPP-A plays an important role in pregnancy and fetal development. Additionally, recent studies indicate a newly...

  8. An interview with Arthur M. "Buzz" Brown, M.D., Ph.D. by Vicki Glaser.

    Science.gov (United States)

    Brown, Arthur M

    2008-12-01

    Dr. Arthur M. "Buzz" Brown is the founder and CEO of ChanTest Corporation, an ion channel company specializing in drug discovery and safety services. He is Adjunct Professor of Physiology and Biophysics, School of Medicine, Case Western Reserve University. Dr. Brown has more than 30 years of experience in ion channel structure-function relationships and their associations with human health. He established world-leading ion channel departments at University of Texas Medical Branch, Baylor College of Medicine, and Case Western Reserve University. His lab first applied liquid ion exchanger ion-selective microelectrodes to single cells, introduced the concept of membrane delimited action of G proteins on ion channels, identified the ion channel conduction pathway or pore of voltage-gated channels and inwardly rectifying potassium channels, showed that the human ether-à-go-go-related gene potassium channel was the molecular target for lethal arrhythmias associated with noncardiac drugs, and established that noncardiac drugs could also produce lethal arrhythmias by inhibiting ion channel trafficking. Dr. Brown holds eight patents on ion channel methodology and application of ion channel pharmacology to therapeutics.

  9. [A PhD completed. Trauma to the gingiva by oral hygiene aids and oral piercings].

    Science.gov (United States)

    Hennequin-Hoenderdos, N L; Slot, D E; van der Weijden, G A

    2017-12-01

    Maintaining healthy teeth and soft oral tissue is important. Clinical research has shown manual toothbrushes with end-rounded filaments to cause significantly less gingival abrasions than those without end-rounding. Tapered filaments are an alternative to end-rounded filaments, but there is no solid evidence for their effectiveness. For the interdental spaces that the toothbrush doesn't reach, the use of special oral hygiene aids is advised. Clinical studies of gingivitis patients have shown that both interdental brushes and plastic-rubber bristles reduce gingivitis after 4 weeks of use. Plastic-rubber bristles result in a significant improvement in the tendency for interdental bleeding compared with interdental brushes, and they cause less abrasion of the gingiva. Other factors that can potentially traumatise soft and hard oral tissue are oral piercings. Wearing oral piercings is not without risk. Tongue and lip piercings are associated with the risk of gingival recession, and tongue piercings are associated with tooth fractures. To prevent the risk of complications, patients should be discouraged from wearing oral piercings.

  10. Transport phenomena in high Tc superconductors. Resume of Ph.D thesis

    International Nuclear Information System (INIS)

    Crisan, I.A.

    1994-01-01

    This is an extended abstract of the Ph. D. thesis devoted to the transport phenomena in high-Tc superconductors. There are three chapters. The first chapter presents an overview of the essential theoretical aspects concerning the vortex dynamics particularly in ceramic superconductors. The chapter two gives a description of the preparation methods of superconductor samples used by the author as well as the measurement devices for volt-ampere characteristics and the associated electronic circuitry. In the third chapter there are presented the experimental data obtained from different samples prepared in different temperature and magnetic field conditions. The obtained results are finally interpreted in the frame of existent or original models. (M.I.C.). 31 Refs

  11. A Course in Critical Thinking for PhD Students in Biomolecular Sciences and Biotechnology: Classical Experiments in Biochemistry

    Directory of Open Access Journals (Sweden)

    Carlos B. Hirschberg

    2016-03-01

    Full Text Available This essay presents and discusses an eight-session seminar course designed to develop critical thinking skills in doctoral biochemistry students by exposing them to classical experiments in biochemistry. During each 2.5 session, different key topics of the discovery and development of biochemical concepts are discussed. Before each session, students are required to read the one or two classical papers. The size of the seminar course and the seating of the students are critical to make this a highly interactive environment for all students to participate in the critique and re-designing of key experiments, including control experiments, which helped formulate these classical concepts. Final student evaluation of the course’s goals has two equal components: Course participation and a final take home exam due two weeks after the course is completed. Together with the take home exam students are also required to write an evaluation of the course, preferably no longer than half a page. Students’ comments of the course have been uniformly positive. The author notes the sooner students are exposed to this manner of thinking, the better they will be equipped to choose an appropriate mentor and contribute creatively to attempt to solve the scientific problem of their PhD thesis.

  12. Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis.

    Science.gov (United States)

    Grapin-Botton, Anne

    2005-01-01

    This review is dedicated to the work on chick digestive tract organogenesis that Nicole Le Douarin performed as a PhD student under the direction of Etienne Wolf. I discuss how she laid the grounds for future work by establishing fate maps at somitic stages, by describing morphogenetic movements between germ layers and by pointing to signaling events between endoderm and mesoderm. Her inspiring work was extended by others, in particular at the molecular level, leading to a better understanding of antero-posterior patterning in the digestive tract. Antero-posterior patterning of endoderm is initiated at gastrulation when future anterior and posterior endoderm ingress at different times and accordingly express different genes. Plasticity is however maintained at somite stages and even later, when organ primordia can be delineated. There is a cross-talk between endoderm and mesoderm and the two layers exchange instructive signals that induce specific antero-posterior identities as well as permissive signals required for organogenesis from previously patterned fields. Recent experiments suggest that several signaling molecules involved in neural tube antero-posterior patterning are also instrumental in the digestive tract including retinoic acid and FGF4.

  13. California State University Long Beach: Model for a Terminal Master's Program as a Bridge to PhD

    Science.gov (United States)

    Bill, Andreas; Kenealy, Patrick; Kwon, Chuhee; Papp, Zoltan; Pickett, Galen T.

    The department of Physics & Astronomy at California State University Long Beach has redesigned its Master's program in 2008 with the goal to provide a true graduate experience in Physics. The hallmarks of the program are five core graduate courses and a research-based MS thesis. During the last five years, 42% of MS recipients (24 students) were accepted to PhD programs, 41% started private-sector STEM careers, and 17% decided on teaching and other paths. The program doubled in size during that period. In 2013 we also became one of six Bridge Sites and only non-PhD granting institution of the American Physical Society (APS). We will describe the structure of the MS program, its goals and its place in the University degree plan landscape. We will also discuss how the APS Bridge Program has been implemented in our institution and has influenced our MS program. We gratefully acknowledge support from a variety of sources that contributed to establish the MS program, including the APS Bridge Program, individual NSF and Army Research Laboratory Grants.

  14. Defense behavior and coping in an autistic savant: the story of Temple Grandin, PhD.

    Science.gov (United States)

    Ratey, J J; Grandin, T; Miller, A

    1992-11-01

    The causal factors in the behaviorally defined syndrome of autism remain unclear, although the past decade has brought to bear two significant developments that shape our view of the disorder. The first of these developments is a growing body of biomedical research that indicates there are multiple etiologies associated with the disorder. This research has allowed for the formation of subgroups based upon neuroanatomical, neurobiological, and neurophysiological abnormalities (Damasio 1984; Piggot 1979; Ritvo et al. 1990). The second is neuropsychological research indicating that the socioemotional deficits are primary to the disorder and may underlie much of the behavioral symptomatology (Fein et al. 1986). These areas of concern undoubtedly have enhanced our understanding of the disorder, yet in their achievements they may too easily absorb what we know about autistics who experience a chronic state of physiological hyperarousal, evidence of which has been found in neurophysiological studies (Delius 1967; Hutt et al. 1965), neurochemical studies (Lake et al. 1977), psychopharmacologic studies (Ratey et al. 1987a), and behavioral studies (Kinsbourne 1980; Kootz et al. 1982; Tinbergen and Tinbergen 1972; Zentall and Zentall 1983). These individuals, perhaps constituting a subgroup of their own, experience an inner state of disorganization that markedly impairs their functioning (Sands and Ratey 1986).

  15. From the Bench to the Clinic Part 1: Martin McIntosh, Ph.D., Introduces His Lab's Immunotherapy Research | Office of Cancer Genomics

    Science.gov (United States)

    The field of immunotherapy is rapidly advancing and genomics techniques are being incorporated to add a “precision” approach. OCG spoke with two CTD2 investigators from the Fred Hutchinson Cancer Research Center (FHCRC) about new advances in immunotherapy. For the first article of this two-part series, we interviewed Martin McIntosh, Ph.D., member of the Fred Hutchinson Translational Research program and previously Program Head in Computational Biology at FHCRC/University of Washington Comprehensive Cancer Center.

  16. Early career researchers and PhD students from the social sciences use of Social Networking Sites (SNS) for science communication: an affordances approach

    OpenAIRE

    Manco Vega, Alejandra

    2017-01-01

    This research aims to understand the different practices and strategies early career researchers and PhD students from the social sciences have in Social Networking Sites (SNSs) for science communication in one particular country: Brazil. Following this purpose, the central research question is which are the motives and rationale of the researchers for using social networking sites for science communication. Two sub-questions arise from this general research question: How do practices and str...

  17. Careers of PhD's: Academic Versus Nonacademic. A Second Report on Follow-up of Doctorate Cohorts 1935-1960.

    Science.gov (United States)

    National Academy of Sciences - National Research Council, Washington, DC.

    Data were collected on the careers of 10,000 holders of research degrees (PhDs, ScDs, and EdDs), via questionnaire, for a second study of PhD holders from the graduating classes of 1935, 1940, 1945, 1950, 1955, and 1960. The careers were systematically selected to represent a cross section of PhDs, and categorized into 4 groups: those always in…

  18. Multidisciplinary Design Techniques Applied to Conceptual Aerospace Vehicle Design. Ph.D. Thesis Final Technical Report

    Science.gov (United States)

    Olds, John Robert; Walberg, Gerald D.

    1993-01-01

    Multidisciplinary design optimization (MDO) is an emerging discipline within aerospace engineering. Its goal is to bring structure and efficiency to the complex design process associated with advanced aerospace launch vehicles. Aerospace vehicles generally require input from a variety of traditional aerospace disciplines - aerodynamics, structures, performance, etc. As such, traditional optimization methods cannot always be applied. Several multidisciplinary techniques and methods were proposed as potentially applicable to this class of design problem. Among the candidate options are calculus-based (or gradient-based) optimization schemes and parametric schemes based on design of experiments theory. A brief overview of several applicable multidisciplinary design optimization methods is included. Methods from the calculus-based class and the parametric class are reviewed, but the research application reported focuses on methods from the parametric class. A vehicle of current interest was chosen as a test application for this research. The rocket-based combined-cycle (RBCC) single-stage-to-orbit (SSTO) launch vehicle combines elements of rocket and airbreathing propulsion in an attempt to produce an attractive option for launching medium sized payloads into low earth orbit. The RBCC SSTO presents a particularly difficult problem for traditional one-variable-at-a-time optimization methods because of the lack of an adequate experience base and the highly coupled nature of the design variables. MDO, however, with it's structured approach to design, is well suited to this problem. The result of the application of Taguchi methods, central composite designs, and response surface methods to the design optimization of the RBCC SSTO are presented. Attention is given to the aspect of Taguchi methods that attempts to locate a 'robust' design - that is, a design that is least sensitive to uncontrollable influences on the design. Near-optimum minimum dry weight solutions are

  19. A Study of Strong Stability of Distributed Systems. Ph.D. Thesis

    Science.gov (United States)

    Cataltepe, Tayfun

    1989-01-01

    The strong stability of distributed systems is studied and the problem of characterizing strongly stable semigroups of operators associated with distributed systems is addressed. Main emphasis is on contractive systems. Three different approaches to characterization of strongly stable contractive semigroups are developed. The first one is an operator theoretical approach. Using the theory of dilations, it is shown that every strongly stable contractive semigroup is related to the left shift semigroup on an L(exp 2) space. Then, a decomposition for the state space which identifies strongly stable and unstable states is introduced. Based on this decomposition, conditions for a contractive semigroup to be strongly stable are obtained. Finally, extensions of Lyapunov's equation for distributed parameter systems are investigated. Sufficient conditions for weak and strong stabilities of uniformly bounded semigroups are obtained by relaxing the equivalent norm condition on the right hand side of the Lyanupov equation. These characterizations are then applied to the problem of feedback stabilization. First, it is shown via the state space decomposition that under certain conditions a contractive system (A,B) can be strongly stabilized by the feedback -B(*). Then, application of the extensions of the Lyapunov equation results in sufficient conditions for weak, strong, and exponential stabilizations of contractive systems by the feedback -B(*). Finally, it is shown that for a contractive system, the first derivative of x with respect to time = Ax + Bu (where B is any linear bounded operator), there is a related linear quadratic regulator problem and a corresponding steady state Riccati equation which always has a bounded nonnegative solution.

  20. Base Input - Enrollment and Graduation Data for Naval Postgraduate School for the School of Business and Public Policy, Meyer Institute of Systems Engineering, and PhD Grads by curriculum by year.

    OpenAIRE

    2005-01-01

    Graphs of Base Input - Enrollment and Graduation Data for Naval Postgraduate School for the School of Business and Public Policy, Meyer Institute of Systems Engineering, and PhD Grads by curriculum by year.

  1. Visible-infrared remote-sensing model and applications for ocean waters. Ph.D. Thesis

    Science.gov (United States)

    Lee, Zhongping

    1994-01-01

    Remote sensing has become important in the ocean sciences, especially for research involving large spatial scales. To estimate the in-water constituents through remote sensing, whether carried out by satellite or airplane, the signal emitted from beneath the sea surface, the so called water-leaving radiance (L(w)), is of prime importance. The magnitude of L(w) depends on two terms: one is the intensity of the solar input, and the other is the reflectance of the in-water constituents. The ratio of the water-leaving radiance to the downwelling irradiance (E(d)) above the sear surface (remote-sensing reflectance, R(sub rs)) is independent of the intensity of the irradiance input, and is largely a function of the optical properties of the in-water constituents. In this work, a model is developed to interpret r(sub rs) for ocean water in the visible-infrared range. In addition to terms for the radiance scattered from molecules and particles, the model includes terms that describe contributions from bottom reflectance, fluorescence of gelbstoff or colored dissolved organic matter (CDOM), and water Raman scattering. By using this model, the measured R(sub rs) of waters from the West Florida Shelf to the Mississippi River plume, which covered a (concentration of chlorophyll a) range of 0.07 - 50 mg/cu m, were well interpreted. The average percentage difference (a.p.d.) between the measured and modeled R(sub rs) is 3.4%, and, for the shallow waters, the model-required water depth is within 10% of the chart depth. Simple mathematical simulations for the phytoplankton pigment absorption coefficient (a(sub theta)) are suggested for using the R(sub rs) model. The inverse problem of R(sub rs), which is to analytically derive the in-water constituents from R(sub rs) data alone, can be solved using the a(sub theta) functions without prior knowledge of the in-water optical properties. More importantly, this method avoids problems associated with a need for knowledge of the shape

  2. Turbulent Jet Flames Into a Vitiated Coflow. PhD Thesis awarded Spring 2003

    Science.gov (United States)

    Holdeman, James D. (Technical Monitor); Cabra, Ricardo

    2004-01-01

    Examined is the vitiated coflow flame, an experimental condition that decouples the combustion processes of flows found in practical combustors from the associated recirculating fluid mechanics. The configuration consists of a 4.57 mm diameter fuel jet into a coaxial flow of hot combustion products from a lean premixed flame. The 210 mm diameter coflow isolates the jet flame from the cool ambient, providing a hot environment similar to the operating conditions of advanced combustors; this important high temperature element is lacking in the traditional laboratory experiments of jet flames into cool (room) air. A family of flows of increasing complexity is presented: 1) nonreacting flow, 2) all hydrogen flame (fuel jet and premixed coflow), and 3) set of methane flames. This sequence of experiments provides a convenient ordering of validation data for combustion models. Laser Raman-Rayleigh-LIF diagnostics at the Turbulent Diffusion Flame laboratory of Sandia National Laboratories produced instantaneous multiscalar point measurements. These results attest to the attractive features of the vitiated coflow burner and the well-defined boundary conditions provided by the coflow. The coflow is uniform and steady, isolating the jet flame from the laboratory air for a downstream distance ranging from z/d = 50-70. The statistical results show that differential diffusion effects in this highly turbulent flow are negligible. Complementing the comprehensive set of multiscalar measurements is a parametric study of lifted methane flames that was conducted to analyze flame sensitivity to jet and coflow velocity, as well as coflow temperature. The linear relationship found between the lift-off height and the jet velocity is consistent with previous experiments. New linear sensitivities were found correlating the lift-off height to coflow velocity and temperature. A blow-off study revealed that the methane flame blows off at a common coflow temperature (1260 K), regardless of

  3. Research that Guides Practice: Outcome Research in Swedish PhD Theses Across Seven Disciplines 1997-2012.

    Science.gov (United States)

    Olsson, Tina M; Sundell, Knut

    2016-05-01

    The core of evidence-based practice (EBP) as advocated for within the practice arms of the health and social sciences is to promote the routine incorporation of the best available research evidence into practice efforts. This requires discipline-specific education that is not only grounded in professional practice but also prepares would-be scientists in the application of the sophisticated techniques that characterize today's high research standards. Doctoral-level education is an important primer for future scientific endeavors across disciplines. This study examined 2334 theses published across Sweden in public health, criminology, nursing, psychiatry, psychology, social work, and sociology during the period 1997-2012. Of the theses reviewed, 13% aimed to investigate the effects of interventions. The highest percentage of effectiveness studies was found in nursing, public health, and psychology. The percentage of outcome research increased during the period. Controlled studies (with comparison group and pre- and post-test) occurred primarily within public health, nursing, psychiatry, and psychology. Of the 296 theses that included an intervention effectiveness study, 131 (44%), or 5.6% of all theses reviewed, met all four assessment criteria for quality. PhD education across seven disciplines in Sweden may be producing a professional core of scientists that is ill prepared to produce the type of research that is necessary to inform practice of the effects of its interventions as exposure to the rigors of quality effectiveness research is all but non-existent. This has implications for the advancement of an evidence-based practice and intervention science more broadly.

  4. PhD Dissertations

    Directory of Open Access Journals (Sweden)

    Redazione Reti Medievali (a cura di

    2005-12-01

    Tra Riforma, vescovo e clientes. Camaldoli e le società locali (secoli XI-XIII, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 [09/05] Giuseppe Gardoni "Episcopus et potestas". Vescovi e società a Mantova nella prima metà del Duecento, Tesi di dottorato di ricerca in Storia del Cristianesimo e delle Chiese (antichità, medioevo, età moderna, Università degli Studi di Padova, 2005 Nicola Mancassola La gestione delle campagne tra Langobardia e Romània in età carolingia e post carolingia. La struttura delle aziende fondiarie in Emilia e Romagna, Tesi di dottorato in Storia Medievale, Università degli Studi di Bologna, 2005 Gloria Papaccio Storia e archeologia degli opifici idraulici in Val di Pesa. La Badia di Passignano e i suoi mulini (XI-XIV secolo, Tesi di dottorato di ricerca in Storia medievale, Università degli studi di Firenze, 2005 Adelaide Ricci La città e il suo ospedale: assetti urbani, dinamiche sociali e organizzazione del sistema caritativo-assistenziale a Cremona nel XV secolo, Tesi di dottorato di ricerca in Storia Medievale, Università degli studi di Torino, 2005 Luca Sant'Ambrogio Il borgo di Treviglio nel secondo Quattrocento: istituzioni e società, Tesi di dottorato di ricerca in Storia Medievale, Università degli Studi di Milano, 2005 Elisabetta Scarton Giovanni Lanfredini. Uomo d'affari e diplomatico nell'Italia del Quattrocento, Tesi di dottorato in Storia della società europea, Università degli Studi di Napoli "Federico II", 2005

  5. An Absorbing Look at Terry-Cloth Towels

    Science.gov (United States)

    Moyer, Richard; Everett, Susan

    2010-01-01

    This article describes a lesson where students explore the absorbency of several towels with different weaves and weights. The lesson follows the 5E learning-cycle model and incorporates engineering in the sense of product testing with a focus on the relationship between the weave of a towel and its absorbency. The National Science Education…

  6. Tchaikovsky, P.: Orchestral Suite no. 3 op. 55 / Terry Williams

    Index Scriptorium Estoniae

    Williams, Terry

    1996-01-01

    Uuest heliplaadist "Tchaikovsky, P.: Orchestral Suite no. 3 op. 55. Francesca di Rimini op. 32. Detroit Symphony Orchestra, Neeme Järvi". Chandos CHAN 9 419, distribution Media 7 (CD: 160F). TT: 1h 09'20"

  7. The methyltransferase NSD3 has chromatin-binding motifs, PHD5-C5HCH, that are distinct from other NSD (nuclear receptor SET domain) family members in their histone H3 recognition.

    Science.gov (United States)

    He, Chao; Li, Fudong; Zhang, Jiahai; Wu, Jihui; Shi, Yunyu

    2013-02-15

    The NSD (nuclear receptor SET domain-containing) family members, consisting of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1), are SET domain-containing methyltransferases and aberrant expression of each member has been implicated in multiple diseases. They have specific mono- and dimethylase activities for H3K36, whereas play nonredundant roles during development. Aside from the well characterized catalytic SET domain, NSD proteins have multiple potential chromatin-binding motifs that are clinically relevant, including the fifth plant homeodomain (PHD5) and the adjacent Cys-His-rich domain (C5HCH) located at the C terminus. Herein, we report the crystal structures of the PHD5-C5HCH module of NSD3, in the free state and in complex with H3(1-7) (H3 residues 1-7), H3(1-15) (H3 residues 1-15), and H3(1-15)K9me3 (H3 residues 1-15 with trimethylation on K9) peptides. These structures reveal that the PHD5 and C5HCH domains fold into a novel integrated PHD-PHD-like structural module with H3 peptide bound only on the surface of PHD5 and provide the molecular basis for the recognition of unmodified H3K4 and trimethylated H3K9 by NSD3 PHD5. Structural studies and binding assays show that differences exist in histone binding specificity of the PHD5 domain between three members of the NSD family. For NSD2, the PHD5-C5HCH:H3 N terminus interaction is largely conserved, although with a stronger preference for unmethylated H3K9 (H3K9me0) than trimethylated H3K9 (H3K9me3), and NSD1 PHD5-C5HCH does not bind to H3 peptides. Our results shed light on how NSD proteins that mediate H3K36 methylation are localized to specific genomic sites and provide implications for the mechanism of functional diversity of NSD proteins.

  8. Career Coaches as a Source of Vicarious Learning for Racial and Ethnic Minority PhD Students in the Biomedical Sciences: A Qualitative Study.

    Science.gov (United States)

    Williams, Simon N; Thakore, Bhoomi K; McGee, Richard

    2016-01-01

    Many recent mentoring initiatives have sought to help improve the proportion of underrepresented racial and ethnic minorities (URMs) in academic positions across the biomedical sciences. However, the intractable nature of the problem of underrepresentation suggests that many young scientists may require supplemental career development beyond what many mentors are able to offer. As an adjunct to traditional scientific mentoring, we created a novel academic career "coaching" intervention for PhD students in the biomedical sciences. To determine whether and how academic career coaches can provide effective career-development-related learning experiences for URM PhD students in the biomedical sciences. We focus specifically on vicarious learning experiences, where individuals learn indirectly through the experiences of others. The intervention is being tested as part of a longitudinal randomized control trial (RCT). Here, we describe a nested qualitative study, using a framework approach to analyze data from a total of 48 semi-structured interviews from 24 URM PhD students (2 interviews per participant, 1 at baseline, 1 at 12-month follow-up) (16 female, 8 male; 11 Black, 12 Hispanic, 1 Native-American). We explored the role of the coach as a source of vicarious learning, in relation to the students' goal of being future biomedical science faculty. Coaches were resources through which most students in the study were able to learn vicariously about how to pursue, and succeed within, an academic career. Coaches were particularly useful in instances where students' research mentors are unable to provide such vicarious learning opportunities, for example because the mentor is too busy to have career-related discussions with a student, or because they have, or value, a different type of academic career to the type the student hopes to achieve. Coaching can be an important way to address the lack of structured career development that students receive in their home training

  9. Biomedical Ph.D. students enrolled in two elite universities in the United kingdom and the United States report adopting multiple learning relationships.

    Science.gov (United States)

    Kemp, Matthew W; Lazarus, Benjamin M; Perron, Gabriel G; Hanage, William P; Chapman, Elaine

    2014-01-01

    The ability to form multiple learning relationships is a key element of the doctoral learning environment in the biomedical sciences. Of these relationships, that between student and supervisor has long been viewed as key. There are, however, limited data to describe the student perspective on what makes this relationship valuable. In the present study, we discuss the findings of semi-structured interviews with biomedical Ph.D. students from the United Kingdom and the United States to: i) determine if the learning relationships identified in an Australian biomedical Ph.D. cohort are also important in a larger international student cohort; and ii) improve our understanding of student perceptions of value in their supervisory relationships. 32 students from two research intensive universities, one in the United Kingdom (n = 17), and one in the United States (n = 15) were recruited to participate in a semi-structured interview. Verbatim transcripts were transcribed, validated and analysed using a Miles and Huberman method for thematic analysis. Students reported that relationships with other Ph.D. students, post-doctoral scientists and supervisors were all essential to their learning. Effective supervisory relationships were perceived as the primary source of high-level project guidance, intellectual support and confidence. Relationships with fellow students were viewed as essential for the provision of empathetic emotional support. Technical learning was facilitated, almost exclusively, by relationships with postdoctoral staff. These data make two important contributions to the scholarship of doctoral education in the biomedical sciences. Firstly, they provide further evidence for the importance of multiple learning relationships in the biomedical doctorate. Secondly, they clarify the form of a 'valued' supervisory relationship from a student perspective. We conclude that biomedical doctoral programs should be designed to contain a minimum level of formalised

  10. Biomedical Ph.D. students enrolled in two elite universities in the United kingdom and the United States report adopting multiple learning relationships.

    Directory of Open Access Journals (Sweden)

    Matthew W Kemp

    Full Text Available The ability to form multiple learning relationships is a key element of the doctoral learning environment in the biomedical sciences. Of these relationships, that between student and supervisor has long been viewed as key. There are, however, limited data to describe the student perspective on what makes this relationship valuable. In the present study, we discuss the findings of semi-structured interviews with biomedical Ph.D. students from the United Kingdom and the United States to: i determine if the learning relationships identified in an Australian biomedical Ph.D. cohort are also important in a larger international student cohort; and ii improve our understanding of student perceptions of value in their supervisory relationships.32 students from two research intensive universities, one in the United Kingdom (n = 17, and one in the United States (n = 15 were recruited to participate in a semi-structured interview. Verbatim transcripts were transcribed, validated and analysed using a Miles and Huberman method for thematic analysis.Students reported that relationships with other Ph.D. students, post-doctoral scientists and supervisors were all essential to their learning. Effective supervisory relationships were perceived as the primary source of high-level project guidance, intellectual support and confidence. Relationships with fellow students were viewed as essential for the provision of empathetic emotional support. Technical learning was facilitated, almost exclusively, by relationships with postdoctoral staff.These data make two important contributions to the scholarship of doctoral education in the biomedical sciences. Firstly, they provide further evidence for the importance of multiple learning relationships in the biomedical doctorate. Secondly, they clarify the form of a 'valued' supervisory relationship from a student perspective. We conclude that biomedical doctoral programs should be designed to contain a minimum level

  11. Outcomes and Processes in the Meyerhoff Scholars Program: STEM PhD Completion, Sense of Community, Perceived Program Benefit, Science Identity, and Research Self-Efficacy.

    Science.gov (United States)

    Maton, Kenneth I; Beason, Tiffany S; Godsay, Surbhi; Sto Domingo, Mariano R; Bailey, TaShara C; Sun, Shuyan; Hrabowski, Freeman A

    2016-01-01

    Previous research has shown that the Meyerhoff Scholars Program at the University of Maryland, Baltimore County, is an effective intervention for high-achieving underrepresented minority (URM) students; African-American Meyerhoff students are significantly more likely to enter science, technology, engineering, and mathematics (STEM) PhD programs than comparison students. The first of two studies in this report extends the prior research by examining levels of PhD completion for Meyerhoff (N = 479) versus comparison sample (N = 249) students among the first 16 cohorts. Entering African-American Meyerhoff students were 4.8 times more likely to complete STEM PhDs than comparison sample students. To enhance understanding of potential mechanisms of influence, the second study used data from the 22nd (Fall 2010) to 25th (Fall 2013) cohorts (N = 109) to test the hypothesis that perceived program benefit at the end of freshman year would mediate the relationship between sense of community at the end of Summer Bridge and science identity and research self-efficacy at the end of sophomore year. Study 2 results indicated that perceived program benefit fully mediated the relationship between sense of community and both criterion measures. The findings underscore the potential of comprehensive STEM intervention programs to enhance PhD completion, and suggest mechanisms of influence. © 2016 K. I. Maton et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  12. Prof. dr. Vesna Vucinic Neškovic - A New President of the World Council of Anthropological Association (WCAA

    Directory of Open Access Journals (Sweden)

    Danijela Velimirović

    2016-02-01

    Full Text Available Vesna Vučinić Nešković PhD, professor at Department of Ethnology and Anthropology,Faculty of Philosophy, University of Belgrade, became in the year 2014 a new President of the World Council of Anthropological Association (WCAA

  13. When You are more Likely to Die of Cancer than Become an Academic: What is the Role of PhD students?

    Directory of Open Access Journals (Sweden)

    Doug Rocks-Macqueen

    2016-04-01

    Full Text Available It was 25 years ago that 'Papers from the Institute of Archaeology' (PIA was launched by postgraduates at the Institute of Archaeology. In the introduction to the first issue David Harris, then Director of the Institute, described the role postgraduates played in creating the journal: ‘I am therefore delighted that several of our current research students have taken the initiative – and put in the necessary sustained effort – to launch Papers from the Institute of Archaeology (PIA. The appearance of this first issue of PIA is the result of much hard work by a dedicated group of postgraduates who not only assumed responsibility for the practicalities of production but also for extracting the contributions from their colleagues and editing them to a high standard! The result is a substantive contribution to archaeological scholarship…’ David Harris (1990 That opening shows a glimpse of the different roles that PhD students play in archaeology: contributors to archaeological scholarship, managers of journals, editors, and much more. It was the role of PhD students in archaeology that I was asked to write about as the opening for this, the 25th anniversary PIA lead article.

  14. ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 4: From Discovery to Cure: The Future of Therapeutics

    Directory of Open Access Journals (Sweden)

    Gianmarco Di Mauro

    2018-05-01

    Full Text Available The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE is an initiative funded by the European Union Horizon 2020 program involving four renowned European Research Institutes (Institute for Research in Biomedicine—IRB Barcelona, Spain; Radboud Institute for Molecular Life Sciences—RIMLS, the Netherlands; Novo Nordisk Foundation Center for Protein Research—NNF CPR, Denmark; European School of Molecular Medicine—SEMM, Italy and an innovative science communication agency (Scienseed. With the aim of promoting biomedical science of excellence in Europe, ENABLE organizes an annual three-day international event. This gathering includes a top-level scientific symposium bringing together leading scientists, PhD students, and post-doctoral fellows; career development activities supporting the progression of young researchers and fostering discussion about opportunities beyond the bench; and outreach activities stimulating the interaction between science and society. The first European PhD and Postdoc Symposium, entitled “Breaking Down Complexity: Innovative Models and Techniques in Biomedicine”, was hosted by the vibrant city of Barcelona. The scientific program of the conference was focused on the most recent advances and applications of modern techniques and models in biomedical research and covered a wide range of topics, from synthetic biology to translational medicine. Overall, the event was a great success, with more than 200 attendees from all over Europe actively participating in the symposium by presenting their research and exchanging ideas with their peers and world-renowned scientists.

  15. ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 4: From Discovery to Cure: The Future of Therapeutics.

    Science.gov (United States)

    Di Mauro, Gianmarco; Dondi, Ambra; Giangreco, Giovanni; Hogrebe, Alexander; Louer, Elja; Magistrati, Elisa; Mullari, Meeli; Turon, Gemma; Verdurmen, Wouter; Xicoy Cortada, Helena; Zivanovic, Sanja

    2018-05-28

    The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European Research Institutes (Institute for Research in Biomedicine-IRB Barcelona, Spain; Radboud Institute for Molecular Life Sciences-RIMLS, the Netherlands; Novo Nordisk Foundation Center for Protein Research-NNF CPR, Denmark; European School of Molecular Medicine-SEMM, Italy) and an innovative science communication agency (Scienseed). With the aim of promoting biomedical science of excellence in Europe, ENABLE organizes an annual three-day international event. This gathering includes a top-level scientific symposium bringing together leading scientists, PhD students, and post-doctoral fellows; career development activities supporting the progression of young researchers and fostering discussion about opportunities beyond the bench; and outreach activities stimulating the interaction between science and society. The first European PhD and Postdoc Symposium, entitled "Breaking Down Complexity: Innovative Models and Techniques in Biomedicine", was hosted by the vibrant city of Barcelona. The scientific program of the conference was focused on the most recent advances and applications of modern techniques and models in biomedical research and covered a wide range of topics, from synthetic biology to translational medicine. Overall, the event was a great success, with more than 200 attendees from all over Europe actively participating in the symposium by presenting their research and exchanging ideas with their peers and world-renowned scientists.

  16. Direct and controllable nitric oxide delivery into biological media and living cells by a pin-to-hole spark discharge (PHD) plasma

    Energy Technology Data Exchange (ETDEWEB)

    Dobrynin, D; Friedman, G [Electrical and Computer Engineering Department, College of Engineering, Drexel University, Philadelphia, PA (United States); Arjunan, K; Clyne, A Morss [School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA (United States); Fridman, A, E-mail: alisam@coe.drexel.edu [Department of Mechanical Engineering and Mechanics, College of Engineering, Drexel University, Philadelphia, PA (United States)

    2011-02-23

    Nitric oxide has great potential for improving wound healing through both inflammatory and vascularization processes. Nitric oxide can be produced in high concentrations by atmospheric pressure thermal plasmas. We measured the physical characteristics and nitric oxide production of a pin-to-hole spark discharge (PHD) plasma, as well as plasma-produced nitric oxide delivery into liquid and endothelial cells. The plasma temperature was calculated as 9030 {+-} 320 K by the Boltzmann method, which was adequate to produce nitric oxide, although the average gas temperature was near room temperature. The plasma produced significant UV radiation and hydrogen peroxide, but these were prevented from reaching the cells by adding a straight or curved tube extension to the plasma device. Plasma-produced nitric oxide in gas reached 2000 ppm and rapidly diffused into liquid and cells. Cells remained viable following plasma treatment and showed a linear increase in cGMP concentration with plasma treatment, indicating an intracellular functional response to PHD plasma NO. These data suggest that this plasma may provide a novel method for delivering NO locally and directly for enhanced wound healing.

  17. Direct and controllable nitric oxide delivery into biological media and living cells by a pin-to-hole spark discharge (PHD) plasma

    International Nuclear Information System (INIS)

    Dobrynin, D; Friedman, G; Arjunan, K; Clyne, A Morss; Fridman, A

    2011-01-01

    Nitric oxide has great potential for improving wound healing through both inflammatory and vascularization processes. Nitric oxide can be produced in high concentrations by atmospheric pressure thermal plasmas. We measured the physical characteristics and nitric oxide production of a pin-to-hole spark discharge (PHD) plasma, as well as plasma-produced nitric oxide delivery into liquid and endothelial cells. The plasma temperature was calculated as 9030 ± 320 K by the Boltzmann method, which was adequate to produce nitric oxide, although the average gas temperature was near room temperature. The plasma produced significant UV radiation and hydrogen peroxide, but these were prevented from reaching the cells by adding a straight or curved tube extension to the plasma device. Plasma-produced nitric oxide in gas reached 2000 ppm and rapidly diffused into liquid and cells. Cells remained viable following plasma treatment and showed a linear increase in cGMP concentration with plasma treatment, indicating an intracellular functional response to PHD plasma NO. These data suggest that this plasma may provide a novel method for delivering NO locally and directly for enhanced wound healing.

  18. Extension of association models to complex chemicals

    DEFF Research Database (Denmark)

    Avlund, Ane Søgaard

    Summary of “Extension of association models to complex chemicals”. Ph.D. thesis by Ane Søgaard Avlund The subject of this thesis is application of SAFT type equations of state (EoS). Accurate and predictive thermodynamic models are important in many industries including the petroleum industry......; CPA and sPC-SAFT. Phase equilibrium and monomer fraction calculations with sPC-SAFT for methanol are used in the thesis to illustrate the importance of parameter estimation when using SAFT. Different parameter sets give similar pure component vapor pressure and liquid density results, whereas very...... association is presented in the thesis, and compared to the corresponding lattice theory. The theory for intramolecular association is then applied in connection with sPC-SAFT for mixtures containing glycol ethers. Calculations with sPC-SAFT (without intramolecular association) are presented for comparison...

  19. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger.

    Science.gov (United States)

    Gangloff, Y G; Pointud, J C; Thuault, S; Carré, L; Romier, C; Muratoglu, S; Brand, M; Tora, L; Couderc, J L; Davidson, I

    2001-08-01

    The RNA polymerase II transcription factor TFIID comprises the TATA binding protein (TBP) and a set of TBP-associated factors (TAF(II)s). TFIID has been extensively characterized for yeast, Drosophila, and humans, demonstrating a high degree of conservation of both the amino acid sequences of the constituent TAF(II)s and overall molecular organization. In recent years, it has been assumed that all the metazoan TAF(II)s have been identified, yet no metazoan homologues of yeast TAF(II)47 (yTAF(II)47) and yTAF(II)65 are known. Both of these yTAF(II)s contain a histone fold domain (HFD) which selectively heterodimerizes with that of yTAF(II)25. We have cloned a novel mouse protein, TAF(II)140, containing an HFD and a plant homeodomain (PHD) finger, which we demonstrated by immunoprecipitation to be a mammalian TFIID component. TAF(II)140 shows extensive sequence similarity to Drosophila BIP2 (dBIP2) (dTAF(II)155), which we also show to be a component of Drosophila TFIID. These proteins are metazoan homologues of yTAF(II)47 as their HFDs selectively heterodimerize with dTAF(II)24 and human TAF(II)30, metazoan homologues of yTAF(II)25. We further show that yTAF(II)65 shares two domains with the Drosophila Prodos protein, a recently described potential dTAF(II). These conserved domains are critical for yTAF(II)65 function in vivo. Our results therefore identify metazoan homologues of yTAF(II)47 and yTAF(II)65.

  20. Construction of a multicontrol sterility system for a maize male-sterile line and hybrid seed production based on the ZmMs7 gene encoding a PHD-finger transcription factor.

    Science.gov (United States)

    Zhang, Danfeng; Wu, Suowei; An, Xueli; Xie, Ke; Dong, Zhenying; Zhou, Yan; Xu, Liwen; Fang, Wen; Liu, Shensi; Liu, Shuangshuang; Zhu, Taotao; Li, Jinping; Rao, Liqun; Zhao, Jiuran; Wan, Xiangyuan

    2018-02-01

    Although hundreds of genetic male sterility (GMS) mutants have been identified in maize, few are commercially used due to a lack of effective methods to produce large quantities of pure male-sterile seeds. Here, we develop a multicontrol sterility (MCS) system based on the maize male sterility 7 (ms7) mutant and its wild-type Zea mays Male sterility 7 (ZmMs7) gene via a transgenic strategy, leading to the utilization of GMS in hybrid seed production. ZmMs7 is isolated by a map-based cloning approach and encodes a PHD-finger transcription factor orthologous to rice PTC1 and Arabidopsis MS1. The MCS transgenic maintainer lines are developed based on the ms7-6007 mutant transformed with MCS constructs containing the (i) ZmMs7 gene to restore fertility, (ii) α-amylase gene ZmAA and/or (iii) DNA adenine methylase gene Dam to devitalize transgenic pollen, (iv) red fluorescence protein gene DsRed2 or mCherry to mark transgenic seeds and (v) herbicide-resistant gene Bar for transgenic seed selection. Self-pollination of the MCS transgenic maintainer line produces transgenic red fluorescent seeds and nontransgenic normal colour seeds at a 1:1 ratio. Among them, all the fluorescent seeds are male fertile, but the seeds with a normal colour are male sterile. Cross-pollination of the transgenic plants to male-sterile plants propagates male-sterile seeds with high purity. Moreover, the transgene transmission rate through pollen of transgenic plants harbouring two pollen-disrupted genes is lower than that containing one pollen-disrupted gene. The MCS system has great potential to enhance the efficiency of maize male-sterile line propagation and commercial hybrid seed production. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  1. STATE, MARKET AND CIVIL SOCIETY AS ACTORS OF DEVELOPMENT: the Challenge of Sustainability in the 21st Century. Interview with Lecturer Heike Doering, PhD

    Directory of Open Access Journals (Sweden)

    Priscila De Nadai

    2016-01-01

    Full Text Available In this edition, professor Priscila De Nadai interviewed Heike Doering, PhD in Sociology from Cardiff University (United Kingdom, lecturer at Cardiff Business School and researcher of the Centre for Local and Regional Government Research, also from Cardiff University. In the past few years,  she has conducted research about reginal development and sustainability management, in emerging economies. One of her research projects is being developed in Espírito Santo in partnership with researchers from our State. In this interview, profesor Heike Doering will tell us about her trajectory as a researcher, about her studies and the specific research she is currently conducting in Espírito Santo.

  2. Origin and diversification of hoverflies: a revision of the genera Asarkina and Allobaccha – A BIG4 Consortium PhD project

    Directory of Open Access Journals (Sweden)

    Trevor Burt

    2017-08-01

    Full Text Available This BIG4 PhD project involves the overall taxonomic revision of the genera Allobaccha Curran and Asarkina Macquart (Diptera: Syrphidae. The revisions will be divided by biogeographic region (Afrotropical and Indomalayan and published accordingly. The publications will be collated as a thesis for submission to the University of Bonn (Rheinische Friedrich-Wilhelms-Universität Bonn, Germany doctoral program of biology. The goal of this project is to resolve alpha taxonomy and to infer the phylogenetic placement of these genera within the Syrphidae using Next-Generation Sequencing and Anchored Hybrid Enrichment techniques. The techniques undertaken in this project will be applied to future systematic problems in Diptera and testing future phylogenetic hypotheses.

  3. Physics on your feet Berkeley graduate exam questions : or ninety minutes of shame but a PhD for the rest of your life!

    CERN Document Server

    Budker, Dmitry; Demas, Vasiliki

    2015-01-01

    Physics on Your Feet gives a collection of physics problems covering the broad range of topics in classical and modern physics that were, or could have been, asked at oral PhD exams at Berkeley. The questions are easy to formulate, but some of them can only be answered using an out-of-the-box approach. Detailed solutions are provided, from which the reader is guaranteed to learn a lot about the physicists' way of thinking. The book is also packed full of cartoons and dry humour to help take the edge off the stress and anxiety surrounding exams. This is a helpful guide to students preparing for their exams, as well as to University lecturers looking for good instructive problems. No exams are necessary to enjoy the book!

  4. Teaching Engineering Ethics to PhD Students : A Berkeley–Delft Initiative: Commentary on “Ethics Across the Curriculum: Prospects for Broader (and Deeper) Teaching and Learning in Research and Engineering Ethics”

    NARCIS (Netherlands)

    Taebi, B.; Kastenberg, William E.

    2016-01-01

    A joint effort by the University of California at Berkeley and Delft University of Technology to develop a graduate engineering ethics course for PhD students encountered two types of challenges: academic and institutional. Academically, long-term collaborative research efforts between

  5. Hyphae colonizing bacteria associated with Penicillium bilaii

    DEFF Research Database (Denmark)

    Ghodsalavi, Behnoushsadat

    shown that mycorrhizal helper bacteria presenting in mycorrhizal fungi could stimulate fungal growth, promote establishment of root-fungus symbiosis and enhance plant production. But it is unknown if the comparable relationship exist between the non-mycorrhizal fungus P. bilaii and its hyphae associated...... bacteria. In the current PhD thesis, we assumed that hyphae-associated microbiome of P. bilaii might harbor helper bacteria with ability to improve fungal growth and P solubilization performance. Therefore, we aimed to isolate bacteria associated with the P. bilaii hyphae and identify the fungal growth...... stimulating bacteria with the perspective of promoting efficiency of Jumpstart in soil – plant system. For this purpose, most of the work within the current project was carried out by development of suitable model systems by mimicking the natural soil habitat to reach to the reliable performance in soil...

  6. Association between Contact allergy and Psoriasis

    DEFF Research Database (Denmark)

    Bangsgaard, Nannie

    2011-01-01

    6. SUMMERY 6.1 Summery in English Allergic contact dermatitis (ACD) and psoriasis are the two most prevalent skin diseases in the western world. ACD is the clinical manifestation of contact allergy. Contact allergy and psoriasis are both due to inflammatory mechanisms involving the innate...... and adaptive immune system. Psoriasis is conceived to be an autoimmune disease. Recent studies have suggested an inverse relation between contact allergy and autoimmune diseases. The association between contact allergy and psoriasis could reveal mechanistic insights into both inflammatory processes....... The overall aim of this PhD study was to investigate the association between contact allergy and autoimmune disease, with focus on psoriasis. The work was done in three study parts. Part I Epidemiological studies. Part II Sensitization study and Part III Experimental studies. In part I the association between...

  7. 78 FR 49764 - Certain Electronic Digital Media Devices and Components Thereof; Commission's Final Determination...

    Science.gov (United States)

    2013-08-15

    ... Job Security; Associated Carrier Group; Capital Policy Analytics; Congresswoman Eva M. Clayton... Sires, Dan Maffei, Terri Sewell, and Steve Israel; Congressman Pete Sessions; CTIA--The Wireless...

  8. Laboratory simulated hydrothermal alteration of sedimentary organic matter from Guaymas Basin, Gulf of California. Ph.D. Thesis

    Science.gov (United States)

    Leif, Roald N.

    1993-01-01

    High temperature alteration of sedimentary organic matter associated with marine hydrothermal systems involves complex physical and chemical processes that are not easily measured in most natural systems. Many of these processes can be evaluated indirectly by examining the geochemistry of the hydrothermal system in the laboratory. In this investigation, an experimental organic geochemical approach to studying pyrolysis of sedimentary organic matter is applied to the hydrothermal system in the Guaymas Basin, Gulf of California. A general survey of hydrothermal oils and extractable organic matter (bitumen) in hydrothermally altered sediments identified several homologous series of alkanones associated with a high temperature hydrothermal origin. The alkanones range in carbon number from C11 to C30 with no carbon number preference. Alkan-2-ones are in highest concentrations, with lower amounts of 3-, 4-, 5- (and higher) homologs. The alkanones appear to be pyrolysis products synthesized under extreme hydrothermal conditions. Hydrous pyrolysis and confinement pyrolysis experiments were performed to simulate thermally enhanced diagenetic and catagenetic changes in the immature sedimentary organic matter. The extent of alteration was measured by monitoring the n-alkanes, acyclic isoprenoids, steroid and triterpenoid biomarkers, polycyclic aromatic hydrocarbons and alkanones. The results were compared to bitumen extracts from sediments which have been naturally altered by a sill intrusion and accompanied hydrothermal fluid flow. These pyrolysis experiments duplicated many of the organic matter transformations observed in the natural system. Full hopane and sterane maturation occurred after 48 hr in experiments at 330 deg C with low water/rock mass ratios (0.29). A variety of radical and ionic reactions are responsible for the organic compound conversions which occur under extreme hydrothermal conditions. Short duration pyrolysis experiments revealed that a portion of the

  9. International Symposium: “Scientific School of L.S. Vygotsky: Traditions and Innovations” and International ISCAR Summer University for PhD Students

    Directory of Open Access Journals (Sweden)

    Baykovskaya N.A.,

    2016-12-01

    Full Text Available The article represents a brief report on the work of the International Symposium: «Scientific School of L.S. Vygotsky: Traditions and Innovations» and VI th International ISCAR Summer University for PhD Students and young scholars, that were held in Moscow State University of Psychology & Education on June, 28 — July, 3 in 2016 in commemoration of the 120th anniversary of the great Russian psychologist L.S. Vygotsky. The main goals of the events organised by MSUPE include: analysis of the basic principles and the system of concepts of L.S. Vygotsky’s scientific school, discussion of the current state and the prospect for the development of the cultural-historical theory in Russia and abroad, integration of the ideas of the cultural-historical psychology and activity approach in various kinds of social and educational practices, as well as conducting research in the international scientific space. Symposium gathered the world’s leading experts and young scholars in the field of cultural-historical theory and activity approach from 19 countries, including United Kingdom, Australia, Switzerland, Greece, Brasil and USA.

  10. Incorporation of autopsy case-based learning into PhD graduate education: a novel approach to bridging the "bench-to-bedside" gap.

    Science.gov (United States)

    Brooks, Erin G; Thornton, Joanne M; Ranheim, Erik A; Fabry, Zsuzsanna

    2017-10-01

    Given the current rapid expansion of biological knowledge and the challenges of translating that knowledge into clinical practice, finding effective methods of teaching graduate students clinical medicine concepts has become even more critical. The utility of autopsy in medical student and resident education has been well established. Multiple studies have reported it to be a helpful means of teaching anatomy, pathophysiology, clinical problem-solving skills, and medical diagnostic techniques. Although various models of training PhD candidates in clinical medicine have been reported, an autopsy-based curriculum has not been previously described. For over 4 years, our pathology department has offered a novel semester-long autopsy-based course to educate future Cellular and Molecular Pathology scientists about clinical medicine. Our results indicate that this "hands-on" approach is a popular as well as effective means of teaching the pathogenesis of disease at the level of the cell, organ, and patient. The course reputation has recently led to requests to open registration to graduate students from other university programs as well as undergraduate students. Additionally, it has played an important role in our Cellular and Molecular Pathology program's recent receipt of a 5-year renewal National Institutes of Health-funded T32 award. Overall, this course model has been successful at our own institution and could provide a useful template for other institutions seeking to provide graduate investigators with in-depth exposure to clinical medicine. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. ‘AN INCREDIBLY STEEP HILL:’ HOW GENDER, RACE, AND CLASS SHAPE PERSPECTIVES ON ACADEMIC CAREERS AMONG BEGINNING BIOMEDICAL PHD STUDENTS

    Science.gov (United States)

    Wood, Christine V.; Campbell, Patricia B.; McGee, Richard

    2017-01-01

    This paper analyzes perspectives on academic careers among 60 beginning PhD students in the biomedical sciences. It presents seven perspectives on academic careers articulated by the students in the sample and explains the way that race/ethnicity, gender, and students’ family education backgrounds are tied to those perspectives. The findings show that traditionally underrepresented students find the academic career path less navigable than students from well-represented groups. Among underrepresented students, even those from higher family education backgrounds, experiences related to race/ethnicity and gender often inform perceptions of the academic career even before they start their graduate research training. As the composition of the graduate population changes to include more women and underrepresented racial and ethnic minority men, it is important to note that not all graduate students enter with the same perspectives and views of the academic career and that there are meaningful differences in perspectives across demographic lines. Graduate programs can play a critical role in providing information and support for graduate students as they navigate their career choices, particularly at the earliest stages of training. By becoming sensitive to students’ perspectives on career options, and understanding how differences in perspectives arise, mentors and others can align advising strategies with the experiences and views of students. PMID:28239250

  12. KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1

    Science.gov (United States)

    Borgel, Julie; Tyl, Marek; Schiller, Karin; Pusztai, Zsofia; Dooley, Christopher M.; Deng, Wen; Wooding, Carol; White, Richard J.; Warnecke, Tobias; Leonhardt, Heinrich; Busch-Nentwich, Elisabeth M.

    2017-01-01

    Abstract Functional genomic elements are marked by characteristic DNA and histone modification signatures. How combinatorial chromatin modification states are recognized by epigenetic reader proteins and how this is linked to their biological function is largely unknown. Here we provide a detailed molecular analysis of chromatin recognition by the lysine demethylase KDM2A. Using biochemical approaches we identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (HP1) interaction motif that mediates direct binding between KDM2A and HP1. This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals. The multivalent engagement with DNA and HP1 results in a nucleosome binding circuit in which KDM2A can be recruited to H3K9me3-modified chromatin through HP1, and HP1 can be recruited to unmodified chromatin by KDM2A. A KDM2A mutant deficient in HP1-binding is inactive in an in vivo overexpression assay in zebrafish embryos demonstrating that the HP1 interaction is essential for KDM2A function. Our results reveal a complex regulation of chromatin binding for both KDM2A and HP1 that is modulated by DNA- and H3K9-methylation, and suggest a direct role for KDM2A in chromatin silencing. PMID:28180290

  13. Interoperable End-to-End Remote Patient Monitoring Platform Based on IEEE 11073 PHD and ZigBee Health Care Profile.

    Science.gov (United States)

    Clarke, Malcolm; de Folter, Joost; Verma, Vivek; Gokalp, Hulya

    2018-05-01

    This paper describes the implementation of an end-to-end remote monitoring platform based on the IEEE 11073 standards for personal health devices (PHD). It provides an overview of the concepts and approaches and describes how the standard has been optimized for small devices with limited resources of processor, memory, and power that use short-range wireless technology. It explains aspects of IEEE 11073, including the domain information model, state model, and nomenclature, and how these support its plug-and-play architecture. It shows how these aspects underpin a much larger ecosystem of interoperable devices and systems that include IHE PCD-01, HL7, and BlueTooth LE medical devices, and the relationship to the Continua Guidelines, advocating the adoption of data standards and nomenclature to support semantic interoperability between health and ambient assisted living in future platforms. The paper further describes the adaptions that have been made in order to implement the standard on the ZigBee Health Care Profile and the experiences of implementing an end-to-end platform that has been deployed to frail elderly patients with chronic disease(s) and patients with diabetes.

  14. [Research in the PhD Program led by János Fehér between 1993 and 2010 at the Biochemical Research Laboratory, 2nd Department of Medicine, Semmelweis University].

    Science.gov (United States)

    Blázovics, Anna

    2010-11-21

    Author wish to express gratitude to late professor János Fehér for the invitation to participate in "Free Radical and Immunological References of Hepatology" PhD program in 1993 and for providing opportunity to establish a laboratory at the 2nd Department of Medicine, Semmelweis University. He established a joint medical and biological research that is continuing unbrokenly. In this research group, between 1993 and 2010, eleven Ph.D. students received their scientific degrees and two candidate dissertations were prepared. Three students are working in this very exciting field even today. Author would like to salute before János Fehér's remembrance by giving a list of results of topics under her leadership.

  15. Mutations in the BAF-Complex Subunit DPF2 Are Associated with Coffin-Siris Syndrome.

    Science.gov (United States)

    Vasileiou, Georgia; Vergarajauregui, Silvia; Endele, Sabine; Popp, Bernt; Büttner, Christian; Ekici, Arif B; Gerard, Marion; Bramswig, Nuria C; Albrecht, Beate; Clayton-Smith, Jill; Morton, Jenny; Tomkins, Susan; Low, Karen; Weber, Astrid; Wenzel, Maren; Altmüller, Janine; Li, Yun; Wollnik, Bernd; Hoganson, George; Plona, Maria-Renée; Cho, Megan T; Thiel, Christian T; Lüdecke, Hermann-Josef; Strom, Tim M; Calpena, Eduardo; Wilkie, Andrew O M; Wieczorek, Dagmar; Engel, Felix B; Reis, André

    2018-03-01

    Variants affecting the function of different subunits of the BAF chromatin-remodelling complex lead to various neurodevelopmental syndromes, including Coffin-Siris syndrome. Furthermore, variants in proteins containing PHD fingers, motifs recognizing specific histone tail modifications, have been associated with several neurological and developmental-delay disorders. Here, we report eight heterozygous de novo variants (one frameshift, two splice site, and five missense) in the gene encoding the BAF complex subunit double plant homeodomain finger 2 (DPF2). Affected individuals share common clinical features described in individuals with Coffin-Siris syndrome, including coarse facial features, global developmental delay, intellectual disability, speech impairment, and hypoplasia of fingernails and toenails. All variants occur within the highly conserved PHD1 and PHD2 motifs. Moreover, missense variants are situated close to zinc binding sites and are predicted to disrupt these sites. Pull-down assays of recombinant proteins and histone peptides revealed that a subset of the identified missense variants abolish or impaire DPF2 binding to unmodified and modified H3 histone tails. These results suggest an impairment of PHD finger structural integrity and cohesion and most likely an aberrant recognition of histone modifications. Furthermore, the overexpression of these variants in HEK293 and COS7 cell lines was associated with the formation of nuclear aggregates and the recruitment of both wild-type DPF2 and BRG1 to these aggregates. Expression analysis of truncating variants found in the affected individuals indicated that the aberrant transcripts escape nonsense-mediated decay. Altogether, we provide compelling evidence that de novo variants in DPF2 cause Coffin-Siris syndrome and propose a dominant-negative mechanism of pathogenicity. Copyright © 2018 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  16. A study of aluminum-lithium alloy solidification using acoustic emission techniques. Ph.D. Thesis, 1991

    Science.gov (United States)

    Henkel, Daniel P.

    1992-01-01

    Physical phenomena associated with the solidification of an aluminum lithium alloy was characterized using acoustic emission (AE) techniques. It is shown that repeatable patterns of AE activity may be correlated to microstructural changes that occur during solidification. The influence of the experimental system on generated signals was examined in the time and frequency domains. The analysis was used to show how an AE signal from solidifying aluminum is changed by each component in the detection system to produce a complex waveform. Conventional AE analysis has shown that a period of high AE activity occurs in pure aluminum, an Al-Cu alloy, and the Al-Li alloy, as the last fraction of solid forms. A model attributes this to the internal stresses of grain boundary formation. An additional period of activity occurs as the last fraction of solid forms, but only in the two alloys. A model attributes this to the formation of interdendritic porosity which was not present in the pure aluminum. The AE waveforms were dominated by resonant effects of the waveguide and the transducer.

  17. Landscape and participation: construction of a PhD research problem and an analysis method. Towards the comparative analysis of participatory processes of landscape management projects design on a local scale in the Walloon region (Belgium)

    OpenAIRE

    Droeven, Emilie

    2007-01-01

    A preliminary reflection to the definition of a PhD research problem on the concepts of participation, landscape and project, led the student to be interested in the participatory processes of landscape management projects design, and in the inhabitants landscapes representations. The method includes the comparative analysis of local processes of projects design, and the direct observation of two Walloon landscape management projects design (investigation conducted with stakeholders implied i...

  18. Komentovaný překlad: Love and Stockholm Syndrome: The Mystery of Loving an Abuser. Joe Carver, PhD. http: drjoecarver.makeswebsites.com/clients/49355/File/love_and_stockholm_syndrome.html

    OpenAIRE

    Vašková, Adéla

    2013-01-01

    This bachelor's thesis consists of a Czech translation of an article Love and Stockholm Syndrome: The Mystery of Loving an Abuser written by an american author Joseph Carver, Ph.D., and a commentary on the translation. The commentary is divided into four parts: an analysis of the source text based on the model of Christiane Nord, the translation problems and their solutions, typology of the translation shifts based on the theory of Anton Popovič and the chosen translation method.

  19. Molecular characterization and mRNA expression of two key enzymes of hypoxia-sensing pathways in eastern oysters Crassostrea virginica (Gmelin): Hypoxia-inducible factor α (HIF-α) and HIF-prolyl hydroxylase (PHD)

    Science.gov (United States)

    Piontkivska, Helen; Chung, J. Sook; Ivanina, Anna V.; Sokolov, Eugene P.; Techa, Sirinart; Sokolova, Inna M.

    2010-01-01

    Oxygen homeostasis is crucial for development, survival and normal function of all metazoans. A family of transcription factors called hypoxia-inducible factors (HIF) is critical in mediating the adaptive responses to reduced oxygen availability. The HIF transcription factor consists of a constitutively expressed β subunit and an oxygen-dependent α subunit; the abundance of the latter determines the activity of HIF and is regulated by a family of O2- and Fe2+-dependent enzymes prolyl hydroxylases (PHDs). Currently very little is known about the function of this important pathway and the molecular structure of its key players in hypoxia-tolerant intertidal mollusks including oysters, which are among the animal champions of anoxic and hypoxic tolerance and thus can serve as excellent models to study the role of HIF cascade in adaptations to oxygen deficiency. We have isolated transcripts of two key components of the oxygen sensing pathway - the oxygen-regulated HIF-α subunit and PHD - from an intertidal mollusk, the eastern oyster Crassostrea virginica, and determined the transcriptional responses of these two genes to anoxia, hypoxia and cadmium (Cd) stress. HIF-α and PHD homologs from eastern oysters C. virginica show significant sequence similarity and share key functional domains with the earlier described isoforms from vertebrates and invertebrates. Phylogenetic analysis shows that genetic diversification of HIF and PHD isoforms occurred within the vertebrate lineage indicating functional diversification and specialization of the oxygen-sensing pathways in this group, which parallels situation observed for many other important genes. HIF-α and PHD homologs are broadly expressed at the mRNA level in different oyster tissues and show transcriptional responses to prolonged hypoxia in the gills consistent with their putative role in oxygen sensing and the adaptive response to hypoxia. Similarity in amino acid sequence, domain structure and transcriptional

  20. Analysis of training load and competition during the PhD course of a 3000-m steeplechase female master athlete: an autobiography

    Directory of Open Access Journals (Sweden)

    Elisa Gabrielli

    2015-08-01

    Full Text Available The first author, Elisa Gabrielli, has been a distance runner for many years, and then at a particular point in her career, she decided to move over to the 3000-m steeplechase. She was attracted by this discipline as she believed that it would be the appropriate discipline for her, due to the challenge it provided her, and the necessary knowledge and awareness she had through her studies. For reasons that are discussed in this report, the 3000-m steeplechase is a race that is more difficult to interpret and manage biomechanically and physiologically than most others. Combining this with her PhD allowed her to use a multidisciplinary approach to review the competitive experience gained in this discipline. During this period, she indeed not only deepened the technical aspects of her training, but also those that underlie this discipline, through her knowledge of sport, with particular reference to the female athlete. Through her technical research, she was able to take ‘snapshots’ of what could happen from the physiological point of view. With satisfaction, she improved her performance in the 3000-m race and in the 3000-m steeplechase. How? In particular, she worked on her running technique through specific exercises. She worked on de-contraction and posture, while saving energy consumption. She worked on the control of her breathing, and she took into account her prevailing heart rate. This was all in combination with the consumption of specific nutrients, as she tried to manage the production of lactate with the training of the red muscle fibres that are rich in mitochondria. Finally, she tried to improve her perception of strenuous work, by training at high altitude. This allowed her not only to improve her physical performance, but especially to improve her mind-set, which allowed her to be more confident in herself and her abilities.