WorldWideScience

Sample records for terrestrial analogue environments

  1. The Planetary Terrestrial Analogues Library (PTAL)

    Science.gov (United States)

    Werner, S. C.; Dypvik, H.; Poulet, F.; Rull Perez, F.; Bibring, J.-P.; Bultel, B.; Casanova Roque, C.; Carter, J.; Cousin, A.; Guzman, A.; Hamm, V.; Hellevang, H.; Lantz, C.; Lopez-Reyes, G.; Manrique, J. A.; Maurice, S.; Medina Garcia, J.; Navarro, R.; Negro, J. I.; Neumann, E. R.; Pilorget, C.; Riu, L.; Sætre, C.; Sansano Caramazana, A.; Sanz Arranz, A.; Sobron Grañón, F.; Veneranda, M.; Viennet, J.-C.; PTAL Team

    2018-04-01

    The Planetary Terrestrial Analogues Library project aims to build and exploit a spectral data base for the characterisation of the mineralogical and geological evolution of terrestrial planets and small solar system bodies.

  2. Astrobiology through the ages of Mars: the study of terrestrial analogues to understand the habitability of Mars.

    Science.gov (United States)

    Fairén, Alberto G; Davila, Alfonso F; Lim, Darlene; Bramall, Nathan; Bonaccorsi, Rosalba; Zavaleta, Jhony; Uceda, Esther R; Stoker, Carol; Wierzchos, Jacek; Dohm, James M; Amils, Ricardo; Andersen, Dale; McKay, Christopher P

    2010-10-01

    Mars has undergone three main climatic stages throughout its geological history, beginning with a water-rich epoch, followed by a cold and semi-arid era, and transitioning into present-day arid and very cold desert conditions. These global climatic eras also represent three different stages of planetary habitability: an early, potentially habitable stage when the basic requisites for life as we know it were present (liquid water and energy); an intermediate extreme stage, when liquid solutions became scarce or very challenging for life; and the most recent stage during which conditions on the surface have been largely uninhabitable, except perhaps in some isolated niches. Our understanding of the evolution of Mars is now sufficient to assign specific terrestrial environments to each of these periods. Through the study of Mars terrestrial analogues, we have assessed and constrained the habitability conditions for each of these stages, the geochemistry of the surface, and the likelihood for the preservation of organic and inorganic biosignatures. The study of these analog environments provides important information to better understand past and current mission results as well as to support the design and selection of instruments and the planning for future exploratory missions to Mars.

  3. Aquatic and Terrestrial Environment 2004

    DEFF Research Database (Denmark)

    Andersen, J. M.; Boutrup, S.; Bijl, L. van der

    This report presents the 2004 results of the Danish National Monitoring and Assess-ment Programme for the Aquatic and Terrestrial Environments (NOVANA). 2004 was the first year in which terrestrial nature was included in the monitoring pro-gramme. The report reviews the state of the groundwater......, watercourses, lakes and marine waters and the pressures upon them and reviews the monitoring of terrestrial natural habitats and selected plants and animals. The report is based on the annual reports prepared for each subprogramme by the Topic Centres. The latter reports are mainly based on data collected...

  4. PTAL Database and Website: Developing a Novel Information System for the Scientific Exploitation of the Planetary Terrestrial Analogues Library

    Science.gov (United States)

    Veneranda, M.; Negro, J. I.; Medina, J.; Rull, F.; Lantz, C.; Poulet, F.; Cousin, A.; Dypvik, H.; Hellevang, H.; Werner, S. C.

    2018-04-01

    The PTAL website will store multispectral analysis of samples collected from several terrestrial analogue sites and pretend to become a cornerstone tool for the scientific community interested in deepening the knowledge on Mars geological processes.

  5. Evaluation of meteorites as habitats for terrestrial microorganisms: Results from the Nullarbor Plain, Australia, a Mars analogue site

    Science.gov (United States)

    Tait, Alastair W.; Wilson, Siobhan A.; Tomkins, Andrew G.; Gagen, Emma J.; Fallon, Stewart J.; Southam, Gordon

    2017-10-01

    Unambiguous identification of biosignatures on Mars requires access to well-characterized, long-lasting geochemical standards at the planet's surface that can be modified by theoretical martian life. Ordinary chondrites, which are ancient meteorites that commonly fall to the surface of Mars and Earth, have well-characterized, narrow ranges in trace element and isotope geochemistry compared to martian rocks. Given that their mineralogy is more attractive to known chemolithotrophic life than the basaltic rocks that dominate the martian surface, exogenic rocks (e.g., chondritic meteorites) may be good places to look for signs of prior life endemic to Mars. In this study, we show that ordinary chondrites, collected from the arid Australian Nullarbor Plain, are commonly colonized and inhabited by terrestrial microorganisms that are endemic to this Mars analogue site. These terrestrial endolithic and chasmolithic microbial contaminants are commonly found in close association with hygroscopic veins of gypsum and Mg-calcite, which have formed within cracks penetrating deep into the meteorites. Terrestrial bacteria are observed within corrosion cavities, where troilite (FeS) oxidation has produced jarosite [KFe3(SO4)2(OH)6]. Where terrestrial microorganisms have colonized primary silicate minerals and secondary calcite, these mineral surfaces are heavily etched. Our results show that inhabitation of meteorites by terrestrial microorganisms in arid environments relies upon humidity and pH regulation by minerals. Furthermore, microbial colonization affects the weathering of meteorites and production of sulfate, carbonate, Fe-oxide and smectite minerals that can preserve chemical and isotopic biosignatures for thousands to millions of years on Earth. Meteorites are thus habitable by terrestrial microorganisms, even under highly desiccating environmental conditions of relevance to Mars. They may therefore be useful as chemical and isotopic ;standards; that preserve evidence of

  6. From the Canadian High Arctic to Mars by Analogue

    Science.gov (United States)

    Soare, R. J.; Pollard, W. H.

    2002-12-01

    Planetary scientists are limited in their understanding of physical bodies in the solar system by the lack of primary data or knowledge. Analogue science is science practised in absentia, precisely in those instances when a non-terrestrial physical environment lies beyond one's direct, empirical grasp. Recognising that some environments on Earth may mirror present or past conditions on Mars, planetary scientists have invoked terrestrial analogues with increasing regularity over the last thirty years as fonts of putative understanding. Notwithstanding its ubiquity in planetary science, analogical reasoning has stood, by and large, unconstrained by rules or guidelines of usage. In order to redress this imbalance we propose to take two steps: 1. introduce primary data on newly discovered pingos at Axel Heiberg Island in the Canadian High Arctic, and 2. coalesce these and related data on Martian glacial, peri-glacial and fluvio-glacial landforms as a model with which to evaluate the meaningfulness of analogical reasoning in planetary science.

  7. Sampling Terrestrial Environments for Bacterial Polyketides

    Directory of Open Access Journals (Sweden)

    Patrick Hill

    2017-04-01

    Full Text Available Bacterial polyketides are highly biologically active molecules that are frequently used as drugs, particularly as antibiotics and anticancer agents, thus the discovery of new polyketides is of major interest. Since the 1980s discovery of polyketides has slowed dramatically due in large part to the repeated rediscovery of known compounds. While recent scientific and technical advances have improved our ability to discover new polyketides, one key area has been under addressed, namely the distribution of polyketide-producing bacteria in the environment. Identifying environments where producing bacteria are abundant and diverse should improve our ability to discover (bioprospect new polyketides. This review summarizes for the bioprospector the state-of-the-field in terrestrial microbial ecology. It provides insight into the scientific and technical challenges limiting the application of microbial ecology discoveries for bioprospecting and summarizes key developments in the field that will enable more effective bioprospecting. The major recent efforts by researchers to sample new environments for polyketide discovery is also reviewed and key emerging environments such as insect associated bacteria, desert soils, disease suppressive soils, and caves are highlighted. Finally strategies for taking and characterizing terrestrial samples to help maximize discovery efforts are proposed and the inclusion of non-actinomycetal bacteria in any terrestrial discovery strategy is recommended.

  8. Application of Terrestrial Environments in Orion Assessments

    Science.gov (United States)

    Barbre, Robert E.

    2016-01-01

    This presentation summarizes the Marshall Space Flight Center Natural Environments Terrestrial and Planetary Environments (TPE) Team support to the NASA Orion space vehicle. The TPE utilizes meteorological data to assess the sensitivities of the vehicle due to the terrestrial environment. The Orion vehicle, part of the Multi-Purpose Crew Vehicle Program, is designed to carry astronauts beyond low-earth orbit and is currently undergoing a series of tests including Exploration Test Flight (EFT) - 1. The presentation describes examples of TPE support for vehicle design and several tests, as well as support for EFT-1 and planning for upcoming Exploration Missions while emphasizing the importance of accounting for the natural environment's impact to the vehicle early in the vehicle's program.

  9. Space Analogue Environments: Are the Populations Comparable?

    Science.gov (United States)

    Sandal, G. M.

    Background: Much of our present understanding about psychology in space is based on studies of groups operating in so-called analogue environments where personnel are exposed to many of the same stressors as those experienced by astronauts in space. One possible problem with extrapolating results is that personnel operating in various hazardous and confined environments might differ in characteristics influencing coping, interaction, and performance. The object of this study was to compare the psychological similarity of these populations in order to get a better understanding of whether this extrapolation is justifiable. The samples investigated include polar crossings (N= 22), personnel on Antarctic research stations (N= 183), several military occupations (N= 187), and participants in space simulation studies (N=20). Methods: Personnel in each of these environments were assessed using the Personality Characteristic Inventory (PCI) and Utrecht Coping List (UCL). The PCI is a multidimensional trait assessment battery that measures various aspects of achievement orientation and social competence. The UCL is a questionnaire designed to assess habitual coping strategies when encountering stressful or demanding situations. Results: Only minor differences in use of habitual coping strategies were evident across the different samples. In relation to personality scores, the military subjects and participants in space simulation studies indicated higher competitiveness and negative instrumentality compared to both the personnel on Antarctic research stations and participants in polar expedition. Among the personnel on Antarctic research stations, significant gender differences were found with women scoring lower on competitiveness, negative instrumentality and impatience/irritability. Compared to the other samples, the participants in polar expeditions were found to be more homogeneous in personality and no significant gender differences were evident on the traits that

  10. Computer-based Role Playing Game Environment for Analogue Electronics

    Directory of Open Access Journals (Sweden)

    Lachlan M MacKinnon

    2009-02-01

    Full Text Available An implementation of a design for a game based virtual learning environment is described. The game is developed for a course in analogue electronics, and the topic is the design of a power supply. This task can be solved in a number of different ways, with certain constraints, giving the students a certain amount of freedom, although the game is designed not to facilitate trial-and-error approach. The use of storytelling and a virtual gaming environment provides the student with the learning material in a MMORPG environment.

  11. Habitability & Astrobiology Research in Mars Terrestrial Analogues

    Science.gov (United States)

    Foing, Bernard

    2014-05-01

    We performed a series of field research campaigns (ILEWG EuroMoonMars) in the extreme Utah desert relevant to Mars environments, and in order to help in the interpretation of Mars missions measurements from orbit (MEX, MRO) or from the surface (MER, MSL), or Moon geochemistry (SMART-1, LRO). We shall give an update on the sample analysis in the context of habitability and astrobiology. Methods & Results: In the frame of ILEWG EuroMoonMars campaigns (2009 to 2013) we deployed at Mars Desert Research station, near Hanksville Utah, a suite of instruments and techniques [A, 1, 2, 9-11] including sample collection, context imaging from remote to local and microscale, drilling, spectrometers and life sensors. We analyzed how geological and geochemical evolution affected local parameters (mineralogy, organics content, environment variations) and the habitability and signature of organics and biota. Among the important findings are the diversity in the composition of soil samples even when collected in close proximity, the low abundances of detectable PAHs and amino acids and the presence of biota of all three domains of life with significant heterogeneity. An extraordinary variety of putative extremophiles was observed [3,4,9]. A dominant factor seems to be soil porosity and lower clay-sized particle content [6-8]. A protocol was developed for sterile sampling, contamination issues, and the diagnostics of biodiversity via PCR and DGGE analysis in soils and rocks samples [10, 11]. We compare the 2009 campaign results [1-9] to new measurements from 2010-2013 campaigns [10-12] relevant to: comparison between remote sensing and in-situ measurements; the study of minerals; the detection of organics and signs of life. Keywords: field analogue research, astrobiology, habitability, life detection, Earth-Moon-Mars, organics References [A] Foing, Stoker & Ehrenfreund (Editors, 2011) "Astrobiology field Research in Moon/Mars Analogue Environments", Special Issue of International

  12. Astrobiology Field Research in Moon/Mars Analogue Environments: Preface

    Science.gov (United States)

    Foing, B. H.; Stoker, C.; Ehrenfreund, P.

    2011-01-01

    Extreme environments on Earth often provide similar terrain conditions to landing/operation sites on Moon and Mars. Several field campaigns (EuroGeoMars2009 and DOMMEX/ILEWG EuroMoonMars from November 2009 to March 2010) were conducted at the Mars Desert Research Station (MDRS) in Utah. Some of the key astrobiology results are presented in this special issue on Astrobiology field research in Moon/Mars analogue environments relevant to investigate the link between geology, minerals, organics and biota. Preliminary results from a multidisciplinary field campaign at Rio Tinto in Spain are presented.

  13. The behaviour of iodine in the terrestrial environment

    International Nuclear Information System (INIS)

    Christiansen, J.V.

    1990-02-01

    Literature on the geochemistry of iodine is surveyed, focusing on fundamental chemical aspects which influence the migration behaviour of iodine in the terrestrial environment. It is stated that the organic fraction in soil plays the predominant role in the retention of iodine. Simple aromatic molecules serve as simple models for humic acid, and humic acid is iodinated catalyzed by haloperoxidases. The enzymatically controlled iodination of humic acid is described in detail and it is demonstrated that the results may reflect a kind of equilibrium. It is shown that soil extracts are able to catalyze the iodination of humic acid and it is suggested that extracellular peroxidases in soil are reponsible for the reaction. The enzymatically controlled iodination of humic acid is discussed and some considerations about the influence on the migration of iodine in the terrestrial environment are given. (author) 4 tabs., 26 ills., 82 refs

  14. The transfer of radionuclides in the terrestrial environment

    International Nuclear Information System (INIS)

    Oehlenschlaeger, M.

    1991-04-01

    The transfer of radionuclides in the terrestrial environment have been investigated. The thesis is divided into two parts. Part I; Dynamic model for the transfer of radionuclides in the terrestrial environment. The study comprises the development of a compartment model, that simulates the dynamic transport of radioactive pollution in the terrestrial environment. The dynamic processes include, dry and wet deposition, soil resuspension, plant growth, root uptake, foliar interception, animal metabolism, agricultural practice, and production of bread. The ingested amount of radioactivity, by man, is multiplied by a dose conversion factor to yield a dose estimate. The dynamic properties and the predictive accuracy of the model have been tested. The results support the dynamics very well and predicitions within a factor of three, of a hypothetical accident, are likely. Part II; Influence of plant variety on the root transfer of radiocaesium. Studies of genetic differences, in plant uptake of radiocaesium, were concluded with a pot experiment. Four varieties of spring barley and three varieties of rye-grass have been tested in two types of soil. The results for barley showed a significant difference between the four varieties. Analyses of variance confirmed a high root uptake of radiocaesium in the variety Sila and a significantly lower root uptake in the variety Apex in each type of soil. The pattern between the varieties was identical in 1988, 1989 and 1990. Similarly for the grass varieties, one variety, the Italian rye grass, was identified as having the relatively highest uptake of radiocaesium. (author) 22 tabs., 30 ills., 56 refs

  15. Ecological effects of transuranics in the terrestrial environment

    International Nuclear Information System (INIS)

    Whicker, F.W.

    1980-01-01

    This chapter explores the ecological effects of transuranium radionuclides in terrestrial environments. No direct studies that relate the level of transuranic contamination to specific changes in structure or function of ecological systems have been carried out. The only alternative approach presently available is to infer such relationships from observations of biota in contaminated environments and models. Advantages and shortcomings of these observations as well as those of the direct experimental approach are discussed

  16. NOVANA. National Monitering and Assessment Programme for the Aquatic and Terrestrial Environments

    DEFF Research Database (Denmark)

    Svendsen, L. M.; Bijl, L. van der; Boutrup, S.

    This report is Part 2 of the Programme Description of NOVANA - the National Monitoring and Assessment Programme for the Aquatic and Terrestrial Environments. Part 2 comprises a de-tailed description of the nine NOVANA subprogrammes: Background monitoring of air......This report is Part 2 of the Programme Description of NOVANA - the National Monitoring and Assessment Programme for the Aquatic and Terrestrial Environments. Part 2 comprises a de-tailed description of the nine NOVANA subprogrammes: Background monitoring of air...

  17. Río Tinto: A Geochemical and Mineralogical Terrestrial Analogue of Mars

    Directory of Open Access Journals (Sweden)

    Ricardo Amils

    2014-09-01

    Full Text Available The geomicrobiological characterization of the water column and sediments of Río Tinto (Huelva, Southwestern Spain have proven the importance of the iron and the sulfur cycles, not only in generating the extreme conditions of the habitat (low pH, high concentration of toxic heavy metals, but also in maintaining the high level of microbial diversity detected in the basin. It has been proven that the extreme acidic conditions of Río Tinto basin are not the product of 5000 years of mining activity in the area, but the consequence of an active underground bioreactor that obtains its energy from the massive sulfidic minerals existing in the Iberian Pyrite Belt. Two drilling projects, MARTE (Mars Astrobiology Research and Technology Experiment (2003–2006 and IPBSL (Iberian Pyrite Belt Subsurface Life Detection (2011–2015, were developed and carried out to provide evidence of subsurface microbial activity and the potential resources that support these activities. The reduced substrates and the oxidants that drive the system appear to come from the rock matrix. These resources need only groundwater to launch diverse microbial metabolisms. The similarities between the vast sulfate and iron oxide deposits on Mars and the main sulfide bioleaching products found in the Tinto basin have given Río Tinto the status of a geochemical and mineralogical Mars terrestrial analogue.

  18. Handbook of the Solar-Terrestrial Environment

    CERN Document Server

    Kamide, Y

    2007-01-01

    The Handbook of the Solar-Terrestrial Environment is a unique compendium. Recognized international leaders in their field contribute chapters on basic topics of solar physics, space plasmas and the Earth's magnetosphere, and on applied topics like the aurora, magnetospheric storms, space weather, space climatology and planetary science. This book will be of highest value as a reference for researchers working in the area of planetary and space science. However, it is also written in a style accessible to graduate students majoring in those fields.

  19. Mercury in the Canadian Arctic terrestrial environment: an update.

    Science.gov (United States)

    Gamberg, Mary; Chételat, John; Poulain, Alexandre J; Zdanowicz, Christian; Zheng, Jiancheng

    2015-03-15

    Contaminants in the Canadian Arctic have been studied over the last twenty years under the guidance of the Northern Contaminants Program. This paper provides the current state of knowledge on mercury (Hg) in the Canadian Arctic terrestrial environment. Snow, ice, and soils on land are key reservoirs for atmospheric deposition and can become sources of Hg through the melting of terrestrial ice and snow and via soil erosion. In the Canadian Arctic, new data have been collected for snow and ice that provide more information on the net accumulation and storage of Hg in the cryosphere. Concentrations of total Hg (THg) in terrestrial snow are highly variable but on average, relatively low (Porcupine caribou herd vary among years but there has been no significant increase or decrease over the last two decades. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. MAFF monitoring of the terrestrial environment

    International Nuclear Information System (INIS)

    Sherlock, J.C.

    1991-01-01

    This paper addresses the MAFF food surveillance programme, in particular our Terrestrial Radioactivity Monitoring Programme (TRAMP), and the estimation of dietary intake of radionuclides. The MAFF programme exists primarily to demonstrate that authorized discharges of radioactivity to the environment do not result in individuals receiving doses of radiation in excess of accepted limits. The estimation radionuclide intake ensures over estimation rather than underestimation of dose. Improvements in detection limits and absorption level research could lower the calculated dose to man from radionuclides in food without losing their validity. (author)

  1. Contaminants in the Greenland terrestrial and freshwater environment. National assessment

    International Nuclear Information System (INIS)

    Riget, F.; Aastrup, P.; Dietz, R.

    1997-01-01

    The present report reviews the available information on heavy metals, persistent organic pollutants and radioactivity in the Greenland freshwater and terrestrial environments. Levels in lake sediments, soil, humus and organisms are presented, spatial and temporal trends are discussed and where possible also biological effects. Many of the contaminants that occur in the Greenland environment originate from distant sources outside of the region, and are transported to the Arctic via three major pathways - atmospheric, terrestrial/freshwater and marine. The main sources of pollution in Greenland is considered to be the industrialization of Eurasia. Pollutants are mainly. The organochlorine levels in Greenland char are typically in the low range compared to values reported from Canada. The Greenland sediment samples showed all organochlorine values below the detection limits of 0.1 μg/kg dry weight, thus being among the lowest contaminated sediments within the Arctic. The total content of PAH in the Greenland sediment samples ranged between 78-635 μ3 g/kg dry wight, with a geometric mean of 178 μg/kg, comparable to or lower than reported values from other arctic countries. The lowest concentrations of anthropogenic radionuclides in the Greenland terrestrial and freshwater environment are found in the northern parts of Greenland and the highest in the south western parts. The main source of anthropogenic radioactivity is nuclear weapons testing in the atmosphere and the fallout from this activity is closely related to the amounts of precipitation. The predominant foodchain in the Arctic with regard to transport of radiocaesium to man is: Lichen-reindeer-man. Although the doses from the terrestrial foodchain are 20 times higher than those received from the marine foodchain, they are not considered to be of any relevance for the human health in Greenland. 4 appendices contain experimental results. (EG)

  2. Mutnovsky and Gorely Volcanoes, Kamchatka as Planetary Analogue Sites

    Science.gov (United States)

    Evdokimova, N.; Izbekov, P. E.; Krupskaya, V.; Muratov, A.

    2016-12-01

    Recent advances in Mars studies suggest that volcanic rocks, which dominated Martian surface in the past, have been exposed to alteration processes in a water-bearing environment during Noachian, before 3.7 Gy. Active volcanoes on Earth are natural laboratories, where volcanic processes and their associated products can be studied directly. This is particularly important for studying of alteration of juvenile volcanic products in aqueous environment because of the transient nature of some of the alteration products, as well as the environment itself. Terrestrial analogues help us to better understand processes on Mars; they are particularly useful as a test sites for preparation to future Mars missions. In this presentation we describe planetary analogue sites at Mutnovsky and Gorely Volcanoes in Kamchatka, which might be helpful for comparative studies and preparation to future Mars missions. Mutnovsky and Gorely Volcanoes are located 75 km south of Petropavlovsk-Kamchatsky, in the southern part of the Kamchatka Peninsula, Russia. The modern volcanic landscape in the area was shaped in Holocene (recent 10,000 years) through intermittent eruption of magmas ranging in composition from basalts to dacites and rhyodacites, with basaltic andesite lavas dominating in the modern relief. Two localities could be of a particular interest: (1) Mutnovsky NW thermal field featuring processes of active hydrothermal alteration of lavas of basaltic andesite and (2) dry lake at the bottom of Gorely caldera featuring products of mechanical disintegration of basaltic andesite lavas by eolian processes with short seasonal sedimentation in aqueous environment.

  3. Po-210 and other radionuclides in terrestrial and freshwater environments

    Energy Technology Data Exchange (ETDEWEB)

    Gjelsvik, Runhild; Brown, Justin [eds.; Norwegian Radiation Protection Authority (Norway); Holm, Elis [Univ. of Lund (Sweden); Roos, Per [Risoe DTU (Denmark); Saxen, Ritva; Outola, Iisa [STUK - Radiation and Nuclear Safety Authority (Finland)

    2009-01-15

    This report provides new information on Po-210 (and where appropriate its grandparent Pb-210) behaviour in environmental systems including humans. This has primarily been achieved through measurements of Po-210 in aquatic and terrestrial environments that has led to the derivation of information on the levels of this radioisotope in plants, animals and the biotic components of their habitat (i.e. water, soil) providing basic information on transfer where practicable. For freshwater environments, Po-210 concentration ratios derived for freshwater benthic fish and bivalve mollusc were substantially different to values collated from earlier review work. For terrestrial environments, activity concentrations of Po-210 in small mammals (although of a preliminary nature because no correction was made for ingrowth from Pb-210) were considerably higher than values derived from earlier data compilations. It was envisaged that data on levels of naturally occurring radionuclides would render underpinning data sets more comprehensive and would thus allow more robust background dose calculations to be performed subsequently. By way of example, unweighted background dose-rates arising from internal distributions of Po-210 were calculated for small mammals in the terrestrial study. The biokinetics of polonium in humans has been studied following chronic and acute oral intakes of selected Po radioisotopes. This work has provided information on gastrointestinal absorption factors and biological retention times thus improving the database upon which committed effective doses to humans are derived. The information generated in the report, in its entirety, should be of direct relevance for both human and non-human impact assessments. (au)

  4. Po-210 and other radionuclides in terrestrial and freshwater environments

    International Nuclear Information System (INIS)

    Gjelsvik, Runhild; Brown, Justin; Roos, Per; Saxen, Ritva; Outola, Iisa

    2009-01-01

    This report provides new information on Po-210 (and where appropriate its grandparent Pb-210) behaviour in environmental systems including humans. This has primarily been achieved through measurements of Po-210 in aquatic and terrestrial environments that has led to the derivation of information on the levels of this radioisotope in plants, animals and the biotic components of their habitat (i.e. water, soil) providing basic information on transfer where practicable. For freshwater environments, Po-210 concentration ratios derived for freshwater benthic fish and bivalve mollusc were substantially different to values collated from earlier review work. For terrestrial environments, activity concentrations of Po-210 in small mammals (although of a preliminary nature because no correction was made for ingrowth from Pb-210) were considerably higher than values derived from earlier data compilations. It was envisaged that data on levels of naturally occurring radionuclides would render underpinning data sets more comprehensive and would thus allow more robust background dose calculations to be performed subsequently. By way of example, unweighted background dose-rates arising from internal distributions of Po-210 were calculated for small mammals in the terrestrial study. The biokinetics of polonium in humans has been studied following chronic and acute oral intakes of selected Po radioisotopes. This work has provided information on gastrointestinal absorption factors and biological retention times thus improving the database upon which committed effective doses to humans are derived. The information generated in the report, in its entirety, should be of direct relevance for both human and non-human impact assessments. (au)

  5. 210Po behaviour in terrestrial environment: a review

    International Nuclear Information System (INIS)

    Coppin, F.; Roussel-Debet, S.

    2004-01-01

    This bibliographical review illustrates the behaviour of 210 polonium in the terrestrial environment. Sources of 210 Po in the atmosphere vary especially with the geographical localization and the occurrence or the absence of mining activities. In soils, polonium, because of its atmospheric origin, is concentrated in the first upper centimeters. 210 Po is rather immobile and adsorbed on mineral surfaces; it can (co)precipitate with metallic (oxi)hydroxides or in the form of sulphide. The main transfer pathway of 210 Po to vegetation is foliar deposit, which is not, or only slightly, followed by incorporation or translocation. 210 Po is transferred to animals mainly by ingestion, with relatively high transfer factors. In fresh waters, 210 Po is generally immobile in the form of insoluble Po(IV) and/or associated with the particulate or colloidal phase. Plankton, invertebrates and fish concentrate the 210 Po, especially in soft tissues. Polonium, which is an omnipresent natural radionuclide, is likely to occasion a significant exposure to man, compared with other natural or artificial radioisotopes. Nearly all studies derive from in situ measurements and are very descriptive, therefore experimental work aiming at a better knowledge and modeling of its behaviour in the terrestrial environment would be useful. (author)

  6. Distribution of {sup 129}I in terrestrial surface water environments

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xuegao [State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Hohai University, Nanjing 210098 (China); College of Hydrology and Water Resources, Hohai University, Nanjing (China); Gong, Meng [College of Hydrology and Water Resources, Hohai University, Nanjing (China); Yi, Peng, E-mail: pengyi1915@163.com [State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Hohai University, Nanjing 210098 (China); College of Hydrology and Water Resources, Hohai University, Nanjing (China); Aldahan, Ala [Department of Earth Sciences, Uppsala University, Uppsala (Sweden); Department of Geology, United Arab Emirates University, Al Ain (United Arab Emirates); Yu, Zhongbo [State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Hohai University, Nanjing 210098 (China); College of Hydrology and Water Resources, Hohai University, Nanjing (China); Possnert, Göran [Tandem Laboratory, Uppsala University, Uppsala (Sweden); Chen, Li [State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Hohai University, Nanjing 210098 (China); College of Hydrology and Water Resources, Hohai University, Nanjing (China)

    2015-10-15

    The global distribution of the radioactive isotope iodine-129 in surface waters (lakes and rivers) is presented here and compared with the atmospheric deposition and distribution in surface marine waters. The results indicate relatively high concentrations in surface water systems in close vicinity of the anthropogenic release sources as well as in parts of Western Europe, North America and Central Asia. {sup 129}I level is generally higher in the terrestrial surface water of the Northern hemisphere compared to the southern hemisphere. The highest values of {sup 129}I appear around 50°N and 40°S in the northern and southern hemisphere, separately. Direct gaseous and marine atmospheric emissions are the most likely avenues for the transport of {sup 129}I from the sources to the terrestrial surface waters. To apply iodine-129 as process tracer in terrestrial surface water environment, more data are needed on {sup 129}I distribution patterns both locally and globally.

  7. Plant volatiles in extreme terrestrial and marine environments.

    Science.gov (United States)

    Rinnan, Riikka; Steinke, Michael; McGenity, Terry; Loreto, Francesco

    2014-08-01

    This review summarizes the current understanding on plant and algal volatile organic compound (VOC) production and emission in extreme environments, where temperature, water availability, salinity or other environmental factors pose stress on vegetation. Here, the extreme environments include terrestrial systems, such as arctic tundra, deserts, CO₂ springs and wetlands, and marine systems such as sea ice, tidal rock pools and hypersaline environments, with mangroves and salt marshes at the land-sea interface. The emission potentials at fixed temperature and light level or actual emission rates for phototrophs in extreme environments are frequently higher than for organisms from less stressful environments. For example, plants from the arctic tundra appear to have higher emission potentials for isoprenoids than temperate species, and hypersaline marine habitats contribute to global dimethyl sulphide (DMS) emissions in significant amounts. DMS emissions are more widespread than previously considered, for example, in salt marshes and some desert plants. The reason for widespread VOC, especially isoprenoid, emissions from different extreme environments deserves further attention, as these compounds may have important roles in stress resistance and adaptation to extremes. Climate warming is likely to significantly increase VOC emissions from extreme environments both by direct effects on VOC production and volatility, and indirectly by altering the composition of the vegetation. © 2014 John Wiley & Sons Ltd.

  8. Effects of solar electromagnetic radiation on the terrestrial environment

    International Nuclear Information System (INIS)

    Dickinson, R.E.

    1986-01-01

    The general intent of this essay is to discuss the effect of solar electromagnetic radiation on the terrestrial environment. Instead of giving a systematic approach considering all environment processes where solar emission is the primary energy source and all important materials which have been generated by solar driven processes, the author sketches an impression of the range of the effects of solar radiation on the environment by surveying a number of topics of particular current interest, in varying levels of detail. These include atmospheric chemistry, some aspects of the transfer of radiation within the atmosphere, global energy balance and climate feedbacks, especially those due to clouds, impacts of fossil fuel energy use, evolution of early life processes, photosynthesis and plant productivity as it relates to photosynthesis and the global carbon cycle. (Auth.)

  9. Physiological Integration Affects Expansion of an Amphibious Clonal Plant from Terrestrial to Cu-Polluted Aquatic Environments

    Science.gov (United States)

    Xu, Liang; Zhou, Zhen-Feng

    2017-03-01

    The effects of physiological integration on clonal plants growing in aquatic and terrestrial habitats have been extensively studied, but little is known about the role in the extension of amphibious clonal plants in the heterogeneous aquatic-terrestrial ecotones, especially when the water environments are polluted by heavy metals. Ramets of the amphibious clonal herb Alternanthera philoxeroides were rooted in unpolluted soil and polluted water at three concentrations of Cu. The extension of populations from unpolluted terrestrial to polluted aqueous environments mainly relied on stem elongation rather than production of new ramets. The absorbed Cu in the ramets growing in polluted water could be spread horizontally to other ramets in unpolluted soil via physiological integration and redistributed in different organs. The performances of ramets in both terrestrial and aquatic habitats were negatively correlated with Cu intensities in different organs of plants. It is concluded that physiological integration might lessen the fitness of connected ramets in heterogeneously polluted environments. The mechanical strength of the stems decreased with increasing Cu levels, especially in polluted water. We suggest that, except for direct toxicity to growth and expansion, heavy metal pollution might also increase the mechanical risk in breaking failure of plants.

  10. Studies of fracture network geometry of reservoir outcrop analogues from terrestrial lidar data: attempts to quantify spatial variations of fracture characteristics

    Science.gov (United States)

    Vsemirnova, E. A.; Jones, R. R.; McCaffrey, K. J. W.

    2012-04-01

    We describe studies analysing terrestrial lidar datasets of fracture systems from a range of reservoir analogues in clastic and carbonate lithologies that represent geological analogues of offshore hydrocarbon reservoirs for the UK continental shelf. As fracture networks (observed here from centimetre to kilometre scale) can significantly affect the permeability of a fractured reservoir, the definition of fracture network geometry at various scales has become an important goal of structural analysis. The main aim of the study has been to extend the investigation of fracture networks in order to quantify spatial variations in fracture parameters in a variety of lithologies. The datasets were pre-processed using RiSCAN PRO software, and then re-sampled and filtered to derive characteristics which are traditionally measured from outcrops, including size distributions, fracture spacing and clustering statistics. This type of analysis can significantly reduce the uncertainty associated with some field fracture network measurements. The digitised fracture networks datasets are then used to investigate various aspects of spatial heterogeneity. A series of fracture maps (joints and faults) were generated at different scales, and fracture trends were studied to test scale dependency of fracture orientations. Multiscale trend analysis was then applied to describe the trend structure of the fracture networks.

  11. Investigation of 210Po/210Pb in terrestrial environment of uranium mineralized area of Jaduguda

    International Nuclear Information System (INIS)

    Sethy, N.K.; Jha, V.N.; Singh, S.; Sharma, B.D.; Sahoo, S.K.; Jha, S.K.; Tripathi, R.M.

    2018-01-01

    Soil is the major components for evaluation of migration characteristics and distribution of radionuclides like 210 Po and 210 Pb in a terrestrial ecosystem. In this study spatial profile of 210 Po in to soil and its equilibrium status with 210 Pb in the terrestrial environment have been studied and correlated with basic soil quality parameters

  12. LASSIE: the large analogue signal and scaling information environment for FAIR

    International Nuclear Information System (INIS)

    Hoffmann, T.; Braeuning, H.; Haseitl, R.

    2012-01-01

    At FAIR, the Facility for Antiproton and Ion Research, several new accelerators and storage rings such as the SIS-100, HESR, CR, the inter-connecting HEBT beam lines, S-FRS and experiments will be built. All of these installations are equipped with beam diagnostic devices and other components, which deliver time-resolved analogue signals to show status, quality and performance of the accelerators. These signals can originate from particle detectors such as ionization chambers and plastic scintillators, but also from adapted output signals of transformers, collimators, magnet functions, RF cavities and others. To visualize and precisely correlate the time axis of all input signals a dedicated FESA based data acquisition and analysis system named LASSIE, the Large Analogue Signal and Scaling Information Environment, is currently being developed. The main operation mode of LASSIE is currently pulse counting with latching VME scaler boards. Later enhancements for ADC, QDC, or TDC digitization in the future are foreseen. The concept, features and challenges of this large distributed data acquisition system are presented. (authors)

  13. Terrestrial Environment (Climatic) Criteria Guidelines for use in Aerospace Vehicle Development. 2008 Revision

    Science.gov (United States)

    Johnson, D. L. (Editor)

    2008-01-01

    This document provides guidelines for the terrestrial environment that are specifically applicable in the development of design requirements/specifications for NASA aerospace vehicles, payloads, and associated ground support equipment. The primary geographic areas encompassed are the John F. Kennedy Space Center, FL; Vandenberg AFB, CA; Edwards AFB, CA; Michoud Assembly Facility, New Orleans, LA; John C. Stennis Space Center, MS; Lyndon B. Johnson Space Center, Houston, TX; George C. Marshall Space Flight Center, Huntsville, AL; and the White Sands Missile Range, NM. This document presents the latest available information on the terrestrial environment applicable to the design and operations of aerospace vehicles and supersedes information presented in NASA-HDBK-1001 and TM X-64589, TM X-64757, TM-78118, TM-82473, and TM-4511. Information is included on winds, atmospheric thermodynamic models, radiation, humidity, precipitation, severe weather, sea state, lightning, atmospheric chemistry, seismic criteria, and a model to predict atmospheric dispersion of aerospace engine exhaust cloud rise and growth. In addition, a section has been included to provide information on the general distribution of natural environmental extremes in the conterminous United States, and world-wide, that may be needed to specify design criteria in the transportation of space vehicle subsystems and components. A section on atmospheric attenuation has been added since measurements by sensors on certain Earth orbital experiment missions are influenced by the Earth s atmosphere. There is also a section on mission analysis, prelaunch monitoring, and flight evaluation as related to the terrestrial environment inputs. The information in these guidelines is recommended for use in the development of aerospace vehicle and related equipment design and associated operational criteria, unless otherwise stated in contract work specifications. The terrestrial environmental data in these guidelines are

  14. Rethinking of the criteria for natural analogue study. A case of Tono natural analogue study

    International Nuclear Information System (INIS)

    Yoshida, Hidekazu

    1996-01-01

    Natural analogue regarding long-term performance of the geological disposal system for radioactive waste isolation is essentially the study of geochemical process which has been evolved in geological environment. All geochemical studies, however, will not be nominated as natural analogue studies. It is, therefore, important to be clear the criteria for natural analogue study with the view of analogy by following three categories, (1) Conceptual model development, (2) Data provision and (3) Model testing, for the concept of geological disposal and safety assessment model. Rethinking of the criteria for natural analogue study through the case of Tono Natural Analogue Study, and the usefulness of natural analogue study for the safety assessment of geological disposal system in Japan have been presented in this paper. (author)

  15. Mars analogue glaciovolcanic hydrothermal environments in Iceland : detection and implications for astrobiology

    OpenAIRE

    Cousins, Claire Rachel; Crawford, Ian; Carrivick, Jonathan; Gunn, Matthew; Harris, Jennifer; Kee, Terence; Karlsson, Magnus; Carmody, Laura; Cockell, Charles; Herschy, Barry; Joy, Katherine

    2013-01-01

    This work was funded by the Leverhulme Trust, and the Science and Technology Facility Council. Volcanism has been a dominant process on Mars, along with a pervasive global cryosphere. Therefore, the interaction between these two is considered likely. Terrestrial glaciovolcanism produces distinctive lithologies and alteration terrains, as well as hydrothermal environments that can be inhabited by microorganisms. Here, we provide a framework for identifying evidence of such glaciovolcanic en...

  16. Modeling and Monitoring Terrestrial Primary Production in a Changing Global Environment: Toward a Multiscale Synthesis of Observation and Simulation

    Directory of Open Access Journals (Sweden)

    Shufen Pan

    2014-01-01

    Full Text Available There is a critical need to monitor and predict terrestrial primary production, the key indicator of ecosystem functioning, in a changing global environment. Here we provide a brief review of three major approaches to monitoring and predicting terrestrial primary production: (1 ground-based field measurements, (2 satellite-based observations, and (3 process-based ecosystem modelling. Much uncertainty exists in the multi-approach estimations of terrestrial gross primary production (GPP and net primary production (NPP. To improve the capacity of model simulation and prediction, it is essential to evaluate ecosystem models against ground and satellite-based measurements and observations. As a case, we have shown the performance of the dynamic land ecosystem model (DLEM at various scales from site to region to global. We also discuss how terrestrial primary production might respond to climate change and increasing atmospheric CO2 and uncertainties associated with model and data. Further progress in monitoring and predicting terrestrial primary production requires a multiscale synthesis of observations and model simulations. In the Anthropocene era in which human activity has indeed changed the Earth’s biosphere, therefore, it is essential to incorporate the socioeconomic component into terrestrial ecosystem models for accurately estimating and predicting terrestrial primary production in a changing global environment.

  17. NOVANA - National Monitoring and Assessment Programme for the Aquatic and Terrestrial Environment

    DEFF Research Database (Denmark)

    Svendsen, L. M.

    This report is Part 1 of the Programme Description of NOVANA - the Nationwide Monitoring and Assessment Programme for the Aquatic and Terrestrial Environments. Part 1 comprises a general description of the background for the programme, including the international obliga-tions and requirements...... for monitoring of nature and the environment. The overall objective and the scientific and strategic background for the priorities upon which NOVANA pro-gramme is based are described, as are the organization of the programme, the overall economy and the technical assumptions made. Finally the scientific content...

  18. Arctic Terrestrial Biodiversity Monitoring Plan

    DEFF Research Database (Denmark)

    Christensen, Tom; Payne, J.; Doyle, M.

    The Conservation of Arctic Flora and Fauna (CAFF), the biodiversity working group of the Arctic Council, established the Circumpolar Biodiversity Monitoring Program (CBMP) to address the need for coordinated and standardized monitoring of Arctic environments. The CBMP includes an international...... on developing and implementing long-term plans for monitoring the integrity of Arctic biomes: terrestrial, marine, freshwater, and coastal (under development) environments. The CBMP Terrestrial Expert Monitoring Group (CBMP-TEMG) has developed the Arctic Terrestrial Biodiversity Monitoring Plan (CBMP......-Terrestrial Plan/the Plan) as the framework for coordinated, long-term Arctic terrestrial biodiversity monitoring. The goal of the CBMP-Terrestrial Plan is to improve the collective ability of Arctic traditional knowledge (TK) holders, northern communities, and scientists to detect, understand and report on long...

  19. Formation mechanisms of trichloromethyl-containing compounds in the terrestrial environment

    DEFF Research Database (Denmark)

    Breider, Florian; Albers, Christian Nyrop

    2015-01-01

    Natural trichloromethyl compounds present in the terrestrial environment are important contributors to chlorine in the lower atmosphere and may be also a cause for concern when high concentrations are detected in soils and groundwater. During the last decade our knowledge of the mechanisms involved...... of trichloromethyl compounds and then to compare these mechanisms with the much more comprehensive literature on the reactions occurring during chemical chlorination of organic material. It turns out that the reaction mechanisms during chemical chlorination are likely to be similar to those occurring naturally...

  20. Microplastics in the terrestrial ecosystem: Implications for Lumbricus terrestris (Oligochaeta, Lumbricidae)

    NARCIS (Netherlands)

    Huerta Lwanga, Esperanza; Gertsen, H.F.; Gooren, H.; Peters, P.D.; Salanki, T.E.; Ploeg, van der M.J.C.; Besseling, E.; Koelmans, A.A.; Geissen, V.

    2016-01-01

    Plastic debris is widespread in the environment, but information on the effects of microplastics on terrestrial fauna is completely lacking. Here, we studied the survival and fitness of the earthworm Lumbricus terrestris (Oligochaeta, Lumbricidae) exposed to microplastics (Polyethylene, <150 μm)

  1. Studies of volatiles and organic materials in early terrestrial and present-day outer solar system environments

    Science.gov (United States)

    Sagan, Carl; Thompson, W. Reid; Chyba, Christopher F.; Khare, B. N.

    1991-01-01

    A review and partial summary of projects within several areas of research generally involving the origin, distribution, chemistry, and spectral/dielectric properties of volatiles and organic materials in the outer solar system and early terrestrial environments are presented. The major topics covered include: (1) impact delivery of volatiles and organic compounds to the early terrestrial planets; (2) optical constants measurements; (3) spectral classification, chemical processes, and distribution of materials; and (4) radar properties of ice, hydrocarbons, and organic heteropolymers.

  2. Fate of rhenium in the environment as a chemical analogue of technetium

    International Nuclear Information System (INIS)

    Tagami, Keiko; Uchida, Shigeo

    2007-01-01

    Concentrations of rhenium, a chemical analogue of Tc, were measured in various environmental samples by ICP-MS to obtain information values on long-lived 99 Tc mobility in the environment. From the results, it was assumed that Re was removed from the rock and soil by water due to weathering and transport to the sea through rivers. The element would be retained in seawater for a long time, i.e., 2 x 10 5 to 7.5 x 10 5 y. The reservoirs of Re in the sea would be seaweeds, and anoxic and suboxic sediments, especially slightly below the water-sediment interface. (author)

  3. Oligo-Miocene peatland ecosystems of the Gippsland Basin and modern analogues

    Science.gov (United States)

    Korasidis, Vera A.; Wallace, Malcolm W.; Wagstaff, Barbara E.; Holdgate, Guy R.

    2017-02-01

    A detailed examination of the brown coal facies preserved in the Latrobe Valley Morwell 1B seam indicates that the type of peat-forming environment and the associated hydrological regime are the main factors influencing the development of lithotypes in brown coal deposits. New palynological data from the Morwell 1B seam suggests that each respective lithotype in the lightening-upwards lithotype cycles was deposited in a particular depositional environment that was characterised by a distinct floral community. The laminated dark lithotype represents a fire-prone emergent marsh that grew on the margins of a coastal lagoon and/or freshwater swamp. This facies grades into the dark lithotype, representing the transition from a meadow marsh to a periodically flooded ombrogenous forested bog. The medium and lighter lithotypes are interpreted as being deposited in an angiosperm-dominated ombrogenous forest bog that was intolerant of fire. These peat-forming environments are interpreted as being largely controlled by moisture and relative depth to water table. Each environment produces distinct lithotypes and lightening-upwards cycles are interpreted as terrestrialization cycles. As the peat grew upwards and above the water table, less moist conditions prevailed and lighter lithotypes were produced. The observed change in colour, from darker to lighter lithotypes, results from the environment evolving from anaerobic/inundated to less anaerobic/less moist settings via terrestrialization. The thin and laterally extensive light and pale lithotypes that top the cycles are interpreted to represent a residual layer of concentrated, oxidation resistant peat-forming elements that result from intense weathering and aerobic degradation of the peats. At a generic level, modern lowland bogs of South Westland in New Zealand have remarkably similar floral/ecological gradients to those of the Oligo-Miocene Morwell 1B brown coal cycles in Australia. This suggests that modern New Zealand

  4. Overview of exposure to and effects from radionuclides in terrestrial and marine environments.

    Science.gov (United States)

    Sample, Bradley E

    2011-07-01

    The accident at the Fukushima Daiichi nuclear power plant, precipitated by the devastating earthquake and subsequent tsunami that struck the northeastern coast of Japan in March 2011, has raised concerns about potential impacts to terrestrial and marine environments from radionuclides released into the environment. A preliminary understanding of the potential ecological impacts from radionuclides can be ascertained from observations and data developed following previous environmental incidents elsewhere in the world. This article briefly summarizes how biota experience exposure to ionizing radiation, what effects may be produced, and how they may differ among taxa and habitats. Copyright © 2011 SETAC.

  5. Textural and mineralogical characteristics of microbial fossils associated with modern and ancient iron (oxyhydr)oxides: terrestrial analogue for sediments in Gale Crater.

    Science.gov (United States)

    Potter-McIntyre, Sally L; Chan, Marjorie A; McPherson, Brian J

    2014-01-01

    Iron (oxyhydr)oxide microbial mats in modern to ∼100 ka tufa terraces are present in a cold spring system along Ten Mile Graben, southeastern Utah, USA. Mats exhibit morphological, chemical, and textural biosignatures and show diagenetic changes that occur over millennial scales. The Jurassic Brushy Basin Member of the Morrison Formation in the Four Corners region of the USA also exhibits comparable microbial fossils and iron (oxyhydr)oxide biosignatures in the lacustrine unit. Both the modern spring system and Brushy Basin Member represent alkaline, saline, groundwater-fed systems and preserve diatoms and other similar algal forms with cellular elaboration. Two distinct suites of elements (1. C, Fe, As and 2. C, S, Se, P) are associated with microbial fossils in modern and ancient iron (oxyhydr)oxides and may be potential markers for biosignatures. The presence of ferrihydrite in ∼100 ka fossil microbial mats and Jurassic rocks suggests that this thermodynamically unstable mineral may also be a potential biomarker. One of the most extensive sedimentary records on Mars is exposed in Gale Crater and consists of non-acidic clays and sulfates possibly of lacustrine origin. These terrestrial iron (oxyhydr)oxide examples are a valuable analogue because of similar iron- and clay-rich host rock compositions and will help (1) understand diagenetic processes in a non-acidic, saline lacustrine environment such as the sedimentary rocks in Gale Crater, (2) document specific biomediated textures, (3) demonstrate how biomediated textures might persist or respond to diagenesis over time, and (4) provide a ground truth library of textures to explore and compare in extraterrestrial iron (oxyhydr)oxides, where future explorations hope to detect past evidence of life.

  6. Migration of radiocesium and radioiodine released by FDNPP accident in the terrestrial environment and its interpretation by their speciation analyses

    International Nuclear Information System (INIS)

    Takahashi, Yoshio; Fan, Qiaohui; Sakaguchi, Aya; Tanaka, Kazuya; Togo, Yoko S.

    2013-01-01

    Distribution of radiocesium and radioiodine such as vertical profile in soil layer, particulate matter-water distribution in river water, and size distributions in sediments were studied to understand their migration in the terrestrial environment in Fukushima area. In addition, speciation studies on cesium and iodine focusing on (1) the surface complex structure of cesium on clay minerals and (2) formation of organoiodine in soil have been conducted, which can clearly explain the possible chemical processes that control the behavior of these radionuclides in the terrestrial environment. (author)

  7. The monitoring of the terrestrial environment around Almirante Alvaro Alberto nuclear power station

    International Nuclear Information System (INIS)

    Tavares, P.G.; Souza, R.F.; Cardoso, S.N.M.

    2011-01-01

    The goal of this paper is to evaluate the environmental monitoring around Almirante Alvaro Alberto Nuclear Power Station after the beginning the operation of Unit II, in July 2000. The Environmental Monitoring Laboratory (EML) has, for purpose, to monitor the environment around the station to verify if there is a potential impact caused by the operation of the units. The EML collects several environmental samples and analyses radiometrically to determine the presence of artificial radionuclides. The types of the samples are marine samples (sea water, fish, algae, beach sand and sediments), terrestrial (milk, banana, soil, grass, superficial and underground water and river water and sediment) and aerial samples (rain water, airborne for iodine and particulate). This paper only describes the monitoring of terrestrial samples. At the EML, the samples are prepared and analysed following international procedures. The samples of milk, banana, soil, grass, surface and underground water, river water and river sediment are analysed by gamma spectrometry in a multi-channel analyser GENIE-2000 System with High-purity Germanium (HpGe) detectors to determine the activities of the detectable radionuclides. The EML also analyses tritium in surface water by liquid scintillation counting. In addition, analysis of 89 Sr/ 9 0 Sr, by beta counting and 131 I by gamma spectrometry are performed in the processed milk. The results are, then, compared with those obtained in pre-operational time of Angra 1 (1978 - 1982) and those obtained in operational time of the units until 2010. The results show us that, from 1982 until now, there is no impact in terrestrial environment caused by the operation neither of Angra 1 nor both Angra 1 and Angra 2. (author)

  8. The monitoring of the terrestrial environment around Almirante Alvaro Alberto nuclear power station

    Energy Technology Data Exchange (ETDEWEB)

    Tavares, P.G.; Souza, R.F.; Cardoso, S.N.M., E-mail: pgtares@eletronuclear.gov.b, E-mail: rfsouza@eletronuclear.gov.b, E-mail: sergion@eletronuclear.gov.b [ELETROBRAS Eletronuclear S.A., Paraty, RJ (Brazil). Lab. de Monitoracao Ambiental

    2011-07-01

    The goal of this paper is to evaluate the environmental monitoring around Almirante Alvaro Alberto Nuclear Power Station after the beginning the operation of Unit II, in July 2000. The Environmental Monitoring Laboratory (EML) has, for purpose, to monitor the environment around the station to verify if there is a potential impact caused by the operation of the units. The EML collects several environmental samples and analyses radiometrically to determine the presence of artificial radionuclides. The types of the samples are marine samples (sea water, fish, algae, beach sand and sediments), terrestrial (milk, banana, soil, grass, superficial and underground water and river water and sediment) and aerial samples (rain water, airborne for iodine and particulate). This paper only describes the monitoring of terrestrial samples. At the EML, the samples are prepared and analysed following international procedures. The samples of milk, banana, soil, grass, surface and underground water, river water and river sediment are analysed by gamma spectrometry in a multi-channel analyser GENIE-2000 System with High-purity Germanium (HpGe) detectors to determine the activities of the detectable radionuclides. The EML also analyses tritium in surface water by liquid scintillation counting. In addition, analysis of {sup 89}Sr/{sup 90}Sr, by beta counting and {sup 131}I by gamma spectrometry are performed in the processed milk. The results are, then, compared with those obtained in pre-operational time of Angra 1 (1978 - 1982) and those obtained in operational time of the units until 2010. The results show us that, from 1982 until now, there is no impact in terrestrial environment caused by the operation neither of Angra 1 nor both Angra 1 and Angra 2. (author)

  9. The solar-terrestrial environment. An introduction to geospace - the science of the terrestrial upper atmosphere, ionosphere and magnetosphere.

    Science.gov (United States)

    Hargreaves, J. K.

    This textbook is a successor to "The upper atmosphere and solar-terrestrial relations" first published in 1979. It describes physical conditions in the upper atmosphere and magnetosphere of the Earth. This geospace environment begins 70 kilometres above the surface of the Earth and extends in near space to many times the Earth's radius. It is the region of near-Earth environment where the Space Shuttle flies, the aurora is generated, and the outer atmosphere meets particles streaming out of the sun. The account is introductory. The intent is to present basic concepts, and for that reason the mathematical treatment is not complex. There are three introductory chapters that give basic physics and explain the principles of physical investigation. The principal material contained in the main part of the book covers the neutral and ionized upper atmosphere, the magetosphere, and structures, dynamics, disturbances and irregularities. The concluding chapter deals with technological applications.

  10. Iberian Pyrite Belt Subsurface Life (IPBSL), a drilling project in a geochemical Mars terrestrial analogue

    Science.gov (United States)

    Amils, R.; Fernández-Remolar, D. C.; Parro, V.; Manfredi, J. A.; Timmis, K.; Oggerin, M.; Sánchez-Román, M.; López, F. J.; Fernández, J. P.; Omoregie, E.; Gómez-Ortiz, D.; Briones, C.; Gómez, F.; García, M.; Rodríguez, N.; Sanz, J. L.

    2012-09-01

    Iberian Pyrite Belt Subsurface Life (IPBSL) is a drilling project specifically designed to characterize the subsurface ecosystems operating in the Iberian Pyrite Belt (IPB), in the area of Peña de Hierro, and responsible of the extreme acidic conditions existing in the Rio Tinto basin [1]. Rio Tinto is considered a good geochemical terrestrial analogue of Mars [2, 3]. A dedicated geophysical characterization of the area selected two drilling sites (4) due to the possible existence of water with high ionic content (low resistivity). Two wells have been drilled in the selected area, BH11 and BH10, of depths of 340 and 620 meters respectively, with recovery of cores and generation of samples in anaerobic and sterile conditions. Preliminary results showed an important alteration of mineral structures associated with the presence of water, with production of expected products from the bacterial oxidation of pyrite (sulfates and ferric iron). Ion chromatography of water soluble compounds from uncontaminated samples showed the existence of putative electron donors (ferrous iron, nitrite in addition of the metal sulfides), electron acceptors (sulfate, nitrate, ferric iron) as well as variable concentration of metabolic organic acids (mainly acetate, formate, propionate and oxalate), which are strong signals of the presence of active subsurface ecosystem associated to the high sulfidic mineral content of the IPB. The system is driven by oxidants that appear to be provided by the rock matrix, only groundwater is needed to launch microbial metabolism. The geological, geomicrobiological and molecular biology analysis which are under way, should allow the characterization of this ecosystem of paramount interest in the design of an astrobiological underground Mars exploration mission in the near future.

  11. Riparian vegetation in the alpine connectome: Terrestrial-aquatic and terrestrial-terrestrial interactions.

    Science.gov (United States)

    Zaharescu, Dragos G; Palanca-Soler, Antonio; Hooda, Peter S; Tanase, Catalin; Burghelea, Carmen I; Lester, Richard N

    2017-12-01

    Alpine regions are under increased attention worldwide for their critical role in early biogeochemical cycles, their high sensitivity to environmental change, and as repositories of natural resources of high quality. Their riparian ecosystems, at the interface between aquatic and terrestrial environments, play important geochemical functions in the watershed and are biodiversity hotspots, despite a harsh climate and topographic setting. With climate change rapidly affecting the alpine biome, we still lack a comprehensive understanding of the extent of interactions between riparian surface, lake and catchment environments. A total of 189 glacial - origin lakes were surveyed in the Central Pyrenees to test how key elements of the lake and terrestrial environments interact at different scales to shape riparian plant composition. Secondly, we evaluated how underlying ecotope features drive the formation of natural communities potentially sensitive to environmental change and assessed their habitat distribution. At the macroscale, vegetation composition responded to pan-climatic gradients altitude and latitude, which captured in a narrow geographic area the transition between large European climatic zones. Hydrodynamics was the main catchment-scale factor connecting riparian vegetation with major water fluxes, followed by topography and geomorphology. Lake sediment Mg and Pb, and water Mn and Fe contents reflected local influences from mafic bedrock and soil water saturation. Community analysis identified four keystone ecosystems: (i) damp ecotone, (ii) snow bed-silicate bedrock, (iii) wet heath, and (iv) calcareous substrate. These communities and their connections with ecotope elements could be at risk from a number of environmental change factors including warmer seasons, snow line and lowland species advancement, increased nutrient/metal input and water level fluctuations. The results imply important natural terrestrial-aquatic linkages in the riparian environment

  12. Does terrestrial epidemiology apply to marine systems?

    Science.gov (United States)

    McCallum, Hamish I.; Kuris, Armand M.; Harvell, C. Drew; Lafferty, Kevin D.; Smith, Garriet W.; Porter, James

    2004-01-01

    Most of epidemiological theory has been developed for terrestrial systems, but the significance of disease in the ocean is now being recognized. However, the extent to which terrestrial epidemiology can be directly transferred to marine systems is uncertain. Many broad types of disease-causing organism occur both on land and in the sea, and it is clear that some emergent disease problems in marine environments are caused by pathogens moving from terrestrial to marine systems. However, marine systems are qualitatively different from terrestrial environments, and these differences affect the application of modelling and management approaches that have been developed for terrestrial systems. Phyla and body plans are more diverse in marine environments and marine organisms have different life histories and probably different disease transmission modes than many of their terrestrial counterparts. Marine populations are typically more open than terrestrial ones, with the potential for long-distance dispersal of larvae. Potentially, this might enable unusually rapid propagation of epidemics in marine systems, and there are several examples of this. Taken together, these differences will require the development of new approaches to modelling and control of infectious disease in the ocean.

  13. Terrestrial Analogs to Mars

    Science.gov (United States)

    Farr, T. G.; Arcone, S.; Arvidson, R. W.; Baker, V.; Barlow, N. G.; Beaty, D.; Bell, M. S.; Blankenship, D. D.; Bridges, N.; Briggs, G.; Bulmer, M.; Carsey, F.; Clifford, S. M.; Craddock, R. A.; Dickerson, P. W.; Duxbury, N.; Galford, G. L.; Garvin, J.; Grant, J.; Green, J. R.; Gregg, T. K. P.; Guinness, E.; Hansen, V. L.; Hecht, M. H.; Holt, J.; Howard, A.; Keszthelyi, L. P.; Lee, P.; Lanagan, P. D.; Lentz, R. C. F.; Leverington, D. W.; Marinangeli, L.; Moersch, J. E.; Morris-Smith, P. A.; Mouginis-Mark, P.; Olhoeft, G. R.; Ori, G. G.; Paillou, P.; Reilly, J. F., II; Rice, J. W., Jr.; Robinson, C. A.; Sheridan, M.; Snook, K.; Thomson, B. J.; Watson, K.; Williams, K.; Yoshikawa, K.

    2002-08-01

    It is well recognized that interpretations of Mars must begin with the Earth as a reference. The most successful comparisons have focused on understanding geologic processes on the Earth well enough to extrapolate to Mars' environment. Several facets of terrestrial analog studies have been pursued and are continuing. These studies include field workshops, characterization of terrestrial analog sites, instrument tests, laboratory measurements (including analysis of Martian meteorites), and computer and laboratory modeling. The combination of all these activities allows scientists to constrain the processes operating in specific terrestrial environments and extrapolate how similar processes could affect Mars. The Terrestrial Analogs for Mars Community Panel has considered the following two key questions: (1) How do terrestrial analog studies tie in to the Mars Exploration Payload Assessment Group science questions about life, past climate, and geologic evolution of Mars, and (2) How can future instrumentation be used to address these questions. The panel has considered the issues of data collection, value of field workshops, data archiving, laboratory measurements and modeling, human exploration issues, association with other areas of solar system exploration, and education and public outreach activities.

  14. Transfer of radionuclides at the uranium and thorium decay chains in aquatic and terrestrial environments

    International Nuclear Information System (INIS)

    Letourneau, C.

    1987-04-01

    This report examines the transfer of radionuclides from the uranium and thorium decay chains (U-238, Ra-226, Th-232, Th-230, Po-210 and Pb-210) through the aquatic and terrestrial environment. This transfer is characterized by a transfer coefficient; environmental and experimental factors which cause this coefficient to vary are presented and discussed in this report. Furthermore, based on a literature survey, the report indicates the range of coefficients found for the aquatic sector (that is, sediment and freshwater and marine organisms) and for the terrestrial sector (that is, plants and domestic and wild animals). Afterwards, generalisations are formulated on the transfer of the different radionuclides through the multiple environmental compartments. 75 refs

  15. Environmental survey near a decommissioning nuclear facility: example of tritium monitoring in the terrestrial environment of Creys-Malville - Environmental survey near a nuclear facility undergoing decommissioning: example of tritium monitoring in the terrestrial environment of Creys-Malville

    Energy Technology Data Exchange (ETDEWEB)

    Boyer, C.; Gontier, G.; Chauveau, J.L. [EDF CIDEN, Division Environnement, 154 Avenue Thiers, 69458 Lyon (France); Pourcelot, L.; Roussel-Debet, S.; Cossonnet, P.C. [IRSN, LERCM Cadarache and LMRE Orsay (France); Jean-Baptiste, P. [LSCE, UMR 1572-CEA/CNRS/UVQS, 91198 Gif sur Yvette (France)

    2014-07-01

    As part of the regulatory environmental monitoring around its nuclear power plants (NPP) in France, EDF carries out more than 40.000 measurements of radionuclides in the environment every year. In addition, EDF performs more detailed radioecological surveys on all of its sites. The purposes of these surveys are: 1/ to control that radioactive discharge limits prescribed by the regulatory authority are respected, 2/ to monitor the environment of the NPPs to verify normal plant operation and to detect all possible failures in power station operation at an early stage and 3/ to establish if there is any increase of radionuclides of anthropogenic origin in the environment and to determine whether this build-up can be attributed to plant operations. Radioecological surveys are conducted in the environment surrounding each of EDF's NPPs. Samples are collected in surrounding ecosystems (terrestrial and aquatic) where the radioactive releases are discharged (liquid and gaseous discharges). These surveys results enable the examination of the spatial distribution and temporal variability of radionuclide activity in the environment throughout the reactors life, from the first fuel load to the decommissioning of the plant. The results from this monitoring have shown that EDF's nuclear power plants have only a minor effect on radionuclide levels in the environment. These results highlight the efficiency of EDF's efforts to minimise its impacts on the environment via an efficient waste management system and high operating standards of its plants. In particular, tritium is subject to special monitoring for more than 30 years; concentrations of free tritium and organically bound tritium in major environmental compartments are therefore well-known in the vicinity of French NPPs. At the end of a reactor's life, EDF has collected a large amount of reference data before decommissioning operations start. During these operations, EDF pursue the radioecological survey

  16. Transport of Iodine Species in the Terrestrial Environment

    International Nuclear Information System (INIS)

    Hu, Q; Moran, J E; Zhao, P

    2003-01-01

    The fate and transport of iodine in the environment is of interest because of the large production and release of 129 I from anthropogenic sources. 129 I has a long half-life (1.57 x 10 7 years) and exhibits complex geochemical behavior. The main source of 129 I in the environment is from nuclear fuel reprocessing facilities; about 2,600 kg from facilities in England and France. During 1944-1972, the Hanford Site in Washington state released about 260 kg 129 I. Iodine has a unique and complex chemistry in the environment, and its fate and transport in aqueous environments is dictated by its chemical speciation. In reducing environments, aqueous iodine usually occurs as the highly mobile iodide anion (I - ). Under more oxidizing conditions, iodine may be present as the more reactive iodate anion (IO 3 - ), which could lead to retarded transport through interaction with clays and organic matter. Co-existing iodine species (I - , IO 3 - , I 2 , and organoiodine compounds), in different proportions, has been reported in various terrestrial environments. However, there are conflicting reports regarding the environmental behavior of the different types of inorganic iodine and few publications on organic iodine compounds. This work examines the sorption and transport behavior of both inorganic and organic iodine species in geological samples from several complexes of the U.S. Department of Energy, where transport of radionuclides, including 129 I, may occur. Experiments on soils and sediments from the Savannah River Site in South Carolina, Oak Ridge Site in Tennessee, Hanford Site in Washington, Livermore Site 300 in California, and a surface soil from Santa Fe in New Mexico near Los Alamos were carried out. Samples from Savannah River Site and Livermore Site 300 are available from different depths. In addition, a surface soil of Wisconsin with a high amount of organic matter is utilized. This wide variety of sample types provides opportunities to examine the influence of

  17. Martian Feeling: An Analogue Study to Simulate a Round-Trip to Mars using the International Space Station

    Science.gov (United States)

    Felix, C. V.; Gini, A.

    When talking about human space exploration, Mars missions are always present. It is clear that sooner or later, humanity will take this adventure. Arguably the most important aspect to consider for the success of such an endeavour is the human element. The safety of the crew throughout a Martian mission is a top priority for all space agencies. Therefore, such a mission should not take place until all the risks have been fully understood and mitigated. A mission to Mars presents unique human and technological challenges in terms of isolation, confinement, autonomy, reliance on mission control, communication delays and adaptation to different gravity levels. Analogue environments provide the safest way to simulate these conditions, mitigate the risks and evaluate the effects of long-term space travel on the crew. Martian Feeling is one of nine analogue studies, from the Mars Analogue Path (MAP) report [1], proposed by the TP Analogue group of ISU Masters class 2010. It is an integrated analogue study which simulates the psychological, physiological and operational conditions that an international, six-person, mixed gender crew would experience on a mission to Mars. Set both onboard the International Space Station (ISS) and on Earth, the Martian Feeling study will perform a ``dress rehearsal'' of a mission to Mars. The study proposes to test both human performance and operational procedures in a cost-effective manner. Since Low Earth Orbit (LEO) is more accessible than other space-based locations, an analogue studies in LEO would provide the required level of realism to a simulated transit mission to Mars. The sustained presence of microgravity and other elements of true spaceflight are features of LEO that are neither currently feasible nor possible to study in terrestrial analogue sites. International collaboration, economics, legal and ethical issues were considered when the study was proposed. As an example of international collaboration, the ISS would

  18. Natural analogue of redox front formation in near-field environment at post-closure phase of HLW geological disposal

    International Nuclear Information System (INIS)

    Yoshida, Hidekazu; Yamamoto, Koushi; Amano, Yuki

    2005-01-01

    Redox fronts are created in the near field of rocks, in a range of oxidation environments, by microbial activity in rock groundwater. Such fronts, and the associated oxide formation, are usually unavoidable around high level radioactive waste (HLW) repositories, whatever their design. The long term behaviour of these oxides after repositories have been closed is however little known. Here we introduce an analogue of redox front formation, such as 'iron oxide' deposits, known as takashikozo forming cylindrical nodules, and the long term behaviour of secondarily formed iron oxyhydroxide in subsequent geological environments. (author)

  19. Microplastics in the Terrestrial Ecosystem: Implications for Lumbricus terrestris (Oligochaeta, Lumbricidae).

    Science.gov (United States)

    Huerta Lwanga, Esperanza; Gertsen, Hennie; Gooren, Harm; Peters, Piet; Salánki, Tamás; van der Ploeg, Martine; Besseling, Ellen; Koelmans, Albert A; Geissen, Violette

    2016-03-01

    Plastic debris is widespread in the environment, but information on the effects of microplastics on terrestrial fauna is completely lacking. Here, we studied the survival and fitness of the earthworm Lumbricus terrestris (Oligochaeta, Lumbricidae) exposed to microplastics (Polyethylene, digestion of ingested organic matter, microplastic was concentrated in cast, especially at the lowest dose (i.e., 7% in litter) because that dose had the highest proportion of digestible organic matter. Whereas 50 percent of the microplastics had a size of earthworms. These concentration-transport and size-selection mechanisms may have important implications for fate and risk of microplastic in terrestrial ecosystems.

  20. Volcanogenic Fluvial-Lacustrine Environments in Iceland and Their Utility for Identifying Past Habitability on Mars

    Directory of Open Access Journals (Sweden)

    Claire Cousins

    2015-02-01

    Full Text Available The search for once-habitable locations on Mars is increasingly focused on environments dominated by fluvial and lacustrine processes, such as those investigated by the Mars Science Laboratory Curiosity rover. The availability of liquid water coupled with the potential longevity of such systems renders these localities prime targets for the future exploration of Martian biosignatures. Fluvial-lacustrine environments associated with basaltic volcanism are highly relevant to Mars, but their terrestrial counterparts have been largely overlooked as a field analogue. Such environments are common in Iceland, where basaltic volcanism interacts with glacial ice and surface snow to produce large volumes of meltwater within an otherwise cold and dry environment. This meltwater can be stored to create subglacial, englacial, and proglacial lakes, or be released as catastrophic floods and proglacial fluvial systems. Sedimentary deposits produced by the resulting fluvial-lacustrine activity are extensive, with lithologies dominated by basaltic minerals, low-temperature alteration assemblages (e.g., smectite clays, calcite, and amorphous, poorly crystalline phases (basaltic glass, palagonite, nanophase iron oxides. This paper reviews examples of these environments, including their sedimentary deposits and microbiology, within the context of utilising these localities for future Mars analogue studies and instrument testing.

  1. Volcanogenic fluvial-lacustrine environments in iceland and their utility for identifying past habitability on Mars.

    Science.gov (United States)

    Cousins, Claire

    2015-02-16

    The search for once-habitable locations on Mars is increasingly focused on environments dominated by fluvial and lacustrine processes, such as those investigated by the Mars Science Laboratory Curiosity rover. The availability of liquid water coupled with the potential longevity of such systems renders these localities prime targets for the future exploration of Martian biosignatures. Fluvial-lacustrine environments associated with basaltic volcanism are highly relevant to Mars, but their terrestrial counterparts have been largely overlooked as a field analogue. Such environments are common in Iceland, where basaltic volcanism interacts with glacial ice and surface snow to produce large volumes of meltwater within an otherwise cold and dry environment. This meltwater can be stored to create subglacial, englacial, and proglacial lakes, or be released as catastrophic floods and proglacial fluvial systems. Sedimentary deposits produced by the resulting fluvial-lacustrine activity are extensive, with lithologies dominated by basaltic minerals, low-temperature alteration assemblages (e.g., smectite clays, calcite), and amorphous, poorly crystalline phases (basaltic glass, palagonite, nanophase iron oxides). This paper reviews examples of these environments, including their sedimentary deposits and microbiology, within the context of utilising these localities for future Mars analogue studies and instrument testing.

  2. The corrosion of depleted uranium in terrestrial and marine environments

    International Nuclear Information System (INIS)

    Toque, C.; Milodowski, A.E.; Baker, A.C.

    2014-01-01

    Depleted Uranium alloyed with titanium is used in armour penetrating munitions that have been fired in a number of conflict zones and testing ranges including the UK ranges at Kirkcudbright and Eskmeals. The study presented here evaluates the corrosion of DU alloy cylinders in soil on these two UK ranges and in the adjacent marine environment of the Solway Firth. The estimated mean initial corrosion rates and times for complete corrosion range from 0.13 to 1.9 g cm −2 y −1 and 2.5–48 years respectively depending on the particular physical and geochemical environment. The marine environment at the experimental site was very turbulent. This may have caused the scouring of corrosion products and given rise to a different geochemical environment from that which could be easily duplicated in laboratory experiments. The rate of mass loss was found to vary through time in one soil environment and this is hypothesised to be due to pitting increasing the surface area, followed by a build up of corrosion products inhibiting further corrosion. This indicates that early time measurements of mass loss or corrosion rate may be poor indicators of late time corrosion behaviour, potentially giving rise to incorrect estimates of time to complete corrosion. The DU alloy placed in apparently the same geochemical environment, for the same period of time, can experience very different amounts of corrosion and mass loss, indicating that even small variations in the corrosion environment can have a significant effect. These effects are more significant than other experimental errors and variations in initial surface area. -- Highlights: ► In-situ experiments were conducted to evaluate corrosion rates of depleted uranium. ► Samples were corroded in marine sediments, open sea water and two terrestrial soils. ► The depleted uranium titanium alloy corroded fastest in the marine environments. ► Rates of mass loss can vary through time if corrosion products are not removed.

  3. Interaction of 238PuO2 heat sources with terrestrial and aquatic environments

    International Nuclear Information System (INIS)

    Patterson, J.H.; Nelson, G.B.; Matlack, G.M.; Waterbury, G.R.

    1975-01-01

    Radioisotope thermoelectric generators used in space missions are designed with a great factor of safety to ensure that they will withstand reentry from orbit and impact with the earth, and safely contain the nuclear fuel until it is recovered. Existing designs, utilizing 238 PuO 2 fuel, have proved more than adequately safe. More data about the interaction of this material with terrestrial and aquatic environments is continually being sought to predict the behavior of these heat sources in the extremely unlikely contact of these materials with the land or ocean. Terrestrial environments are simulated with large environmental chambers that permit control of temperature, humidity, and rainfall using different kinds of soils. Rain falling on thermally hot chunks of 238 PuO 2 causes the spallation of the surface of the fuel into extremely fine particles, as small as 50 nm, that are later transported downward through the soil. Some of the plutonia particles become agglomerated with soil particles. Plutonium transport is more significant during winter than during summer because evaporation losses from the soil are less in winter. Aquatic environments are simulated with large aquaria that provide temperature and aeration control. Earlier fuel designs that employed a plutonia-molybdenum cermet showed plutonium release rates of about 10 μCi/m 2 - s, referred to the total surface area of the cermet. Present advanced fuels, employing pure plutonium oxide, show release rates of about 20 nCi/m 2 - s in seawater and about 150 nCi/m 2 - s in freshwater. The temperature of these more advanced heat sources does not seem to affect the release rate in seawater. (auth)

  4. New seismic instrumentation packaged for all terrestrial environments (including the quietest observatories!).

    Science.gov (United States)

    Parker, Tim; Devanney, Peter; Bainbridge, Geoff; Townsend, Bruce

    2017-04-01

    The march to make every type of seismometer, weak to strong motion, reliable and economically deployable in any terrestrial environment continues with the availability of three new sensors and seismic systems including ones with over 200dB of dynamic range. Until recently there were probably 100 pier type broadband sensors for every observatory type pier, not the types of deployments geoscientists are needing to advance science and monitoring capability. Deeper boreholes are now the recognized quieter environments for best observatory class instruments and these same instruments can now be deployed in direct burial environments which is unprecedented. The experiences of facilities in large deployments of broadband seismometers in continental scale rolling arrays proves the utility of packaging new sensors in corrosion resistant casings and designing in the robustness needed to work reliably in temporary deployments. Integrating digitizers and other sensors decreases deployment complexity, decreases acquisition and deployment costs, increases reliability and utility. We'll discuss the informed evolution of broadband pier instruments into the modern integrated field tools that enable economic densification of monitoring arrays along with supporting new ways to approach geoscience research in a field environment.

  5. Characterizing Terrestrial Exoplanets

    Science.gov (United States)

    Meadows, V. S.; Lustig-Yaeger, J.; Lincowski, A.; Arney, G. N.; Robinson, T. D.; Schwieterman, E. W.; Deming, L. D.; Tovar, G.

    2017-11-01

    We will provide an overview of the measurements, techniques, and upcoming missions required to characterize terrestrial planet environments and evolution, and search for signs of habitability and life.

  6. Physics-based Space Weather Forecasting in the Project for Solar-Terrestrial Environment Prediction (PSTEP) in Japan

    Science.gov (United States)

    Kusano, K.

    2016-12-01

    Project for Solar-Terrestrial Environment Prediction (PSTEP) is a Japanese nation-wide research collaboration, which was recently launched. PSTEP aims to develop a synergistic interaction between predictive and scientific studies of the solar-terrestrial environment and to establish the basis for next-generation space weather forecasting using the state-of-the-art observation systems and the physics-based models. For this project, we coordinate the four research groups, which develop (1) the integration of space weather forecast system, (2) the physics-based solar storm prediction, (3) the predictive models of magnetosphere and ionosphere dynamics, and (4) the model of solar cycle activity and its impact on climate, respectively. In this project, we will build the coordinated physics-based model to answer the fundamental questions concerning the onset of solar eruptions and the mechanism for radiation belt dynamics in the Earth's magnetosphere. In this paper, we will show the strategy of PSTEP, and discuss about the role and prospect of the physics-based space weather forecasting system being developed by PSTEP.

  7. Water, soil, crops and radionuclides. Studies on the behavior of radionuclides in the terrestrial environments

    International Nuclear Information System (INIS)

    Uchida, Shigeo

    2008-01-01

    In order to predict the migration of artificially-produced radionuclides into a human body and its radiation dose rates of human body and to decrease the exposed radiation doses of human body, the behavior of radionuclides in the environment must be elucidated. In National Institute of Radiological Sciences (NIRS), the environmental radioecological research group of Nakaminato Laboratory for Marine Radioecology has progressed the survey and research on the behavior of artificially-produced radionuclides in the terrestrial environment. This article describes the research results (the radioactivity of water, soil, and crops) made so far at Nakaminato Laboratory for Marine Radioecology. (M.H.)

  8. MODIS-derived terrestrial primary production [chapter 28

    Science.gov (United States)

    Maosheng Zhao; Steven Running; Faith Ann Heinsch; Ramakrishna Nemani

    2011-01-01

    Temporal and spatial changes in terrestrial biological productivity have a large impact on humankind because terrestrial ecosystems not only create environments suitable for human habitation, but also provide materials essential for survival, such as food, fiber and fuel. A recent study estimated that consumption of terrestrial net primary production (NPP; a list of...

  9. Results of the first Seismometer to Investigate Ice and Ocean Structure (SIIOS) Analogue Mission

    Science.gov (United States)

    Della-Giustina, Daniella; Bray, Veronica; "Hop" Bailey, Samuel; Pettit, Erin; Schmerr, Nicholas; Dahl, Peter; Avenson, Brad; Byrne, Shane; SIIOS Team

    2017-10-01

    The icy moons of Europa and Enceladus are thought to have global subsurface oceans in contact with mineral-rich interiors, likely providing the ingredients needed for life as we know it. The possibility of life forming in the ocean or in melt pockets, relies on the presence of a source of energy and chemistry for biological molecule formation. A thick, stagnant ice crust would likely prevent transfer of oxidants from the surface to the water, halting the development of life. The ice thickness and structure is therefore one of the most important and controversial topics in astrobiology.The best way to access an icy moon’s interior structure is with a lander-based seismometer. Our team has identified a commercial-off-the-shelf device as a flight-candidate for operation in the extreme environment of the icy moons. Based on estimates of Europan seismicity, the flight candidate device is sensitive enough to detect the ice-water boundary and pockets of liquid within the ice. Its low mass and low power enables deployment of multiple seismometers in a short-baseline array on a lander. The performance, mass, and volume of this device meet or exceed flight requirements identified in lander studies making a field test of these seismometers highly representative of a flight unit developed for an Ocean Worlds mission.We report the results of the first field campaign for the SIIOS Analogue Mission Program (AMP), which has evaluates the performance of the flight candidate seismometer in Ocean World terrestrial analogue environments. In particular, the first SIIOS AMP field exercise is performed at Gulkana Glacier, Alaska. During the summer melt season Gulkana provides kilometer-scale regions of coexisting ice, water, and silicate material, thereby providing areas with the desired analogue seismic contrasts. During this first mission, we have demonstrated device sensitivity to the detection of seismicity from high frequency (> 50 Hz) active and passive sources, the depth of ice

  10. The Solar-Terrestrial Environment

    Science.gov (United States)

    Hargreaves, John Keith

    1995-05-01

    The book begins with three introductory chapters that provide some basic physics and explain the principles of physical investigation. The principal material contained in the main part of the book covers the neutral and ionized upper atmosphere, the magnetosphere, and structures, dynamics, disturbances, and irregularities. The concluding chapter deals with technological applications. The account is introductory, at a level suitable for readers with a basic background in engineering or physics. The intent is to present basic concepts, and for that reason, the mathematical treatment is not complex. SI units are given throughout, with helpful notes on cgs units where these are likely to be encountered in the research literature. This book is suitable for advanced undergraduate and graduate students who are taking introductory courses on upper atmospheric, ionospheric, or magnetospheric physics. This is a successor to The Upper Atmosphere and Solar-Terrestrial Relations, published in 1979.

  11. Contaminant exposure in terrestrial vertebrates

    International Nuclear Information System (INIS)

    Smith, Philip N.; Cobb, George P.; Godard-Codding, Celine; Hoff, Dale; McMurry, Scott T.; Rainwater, Thomas R.; Reynolds, Kevin D.

    2007-01-01

    Here we review mechanisms and factors influencing contaminant exposure among terrestrial vertebrate wildlife. There exists a complex mixture of biotic and abiotic factors that dictate potential for contaminant exposure among terrestrial and semi-terrestrial vertebrates. Chemical fate and transport in the environment determine contaminant bioaccessibility. Species-specific natural history characteristics and behavioral traits then play significant roles in the likelihood that exposure pathways, from source to receptor, are complete. Detailed knowledge of natural history traits of receptors considered in conjunction with the knowledge of contaminant behavior and distribution on a site are critical when assessing and quantifying exposure. We review limitations in our understanding of elements of exposure and the unique aspects of exposure associated with terrestrial and semi-terrestrial taxa. We provide insight on taxa-specific traits that contribute, or limit exposure to, transport phenomenon that influence exposure throughout terrestrial systems, novel contaminants, bioavailability, exposure data analysis, and uncertainty associated with exposure in wildlife risk assessments. Lastly, we identify areas related to exposure among terrestrial and semi-terrestrial organisms that warrant additional research. - Both biotic and abiotic factors determine chemical exposure for terrestrial vertebrates

  12. Analogue Gravity

    Directory of Open Access Journals (Sweden)

    Carlos Barceló

    2011-05-01

    Full Text Available Analogue gravity is a research programme which investigates analogues of general relativistic gravitational fields within other physical systems, typically but not exclusively condensed matter systems, with the aim of gaining new insights into their corresponding problems. Analogue models of (and for gravity have a long and distinguished history dating back to the earliest years of general relativity. In this review article we will discuss the history, aims, results, and future prospects for the various analogue models. We start the discussion by presenting a particularly simple example of an analogue model, before exploring the rich history and complex tapestry of models discussed in the literature. The last decade in particular has seen a remarkable and sustained development of analogue gravity ideas, leading to some hundreds of published articles, a workshop, two books, and this review article. Future prospects for the analogue gravity programme also look promising, both on the experimental front (where technology is rapidly advancing and on the theoretical front (where variants of analogue models can be used as a springboard for radical attacks on the problem of quantum gravity.

  13. Use of analogues to build technologists' confidence: NAnet

    International Nuclear Information System (INIS)

    Noseck, Ulrich

    2008-01-01

    processes occurring at the geosphere-biosphere interface and in the surface environment. One of the primary outputs of the NAnet project has been the compilation of reviews of more than 70 individual analogue studies with relevance for the near-field, far field or biosphere. Each analogue study review was documented using a standard review template that includes sections concerned with performance assessment relevance and applications, limitations of the analogue, a summary of any particular quantitative information derived from the study, an assessment of the uncertainties associated with the qualitative and quantitative information, an indication of the time-scales covered by the analogue and reference to any applications in communication and links to the primary literature. A simple referencing system was developed that enables safety assessors and communication specialists rapidly to find all those analogues that relate to their specific issues and interests. It is based on a simple matrix that has on one axis the range of materials and on the other axis the range of processes that can occur in the repository system. Intersections of the axes identify unique material-process combinations and analogue studies can be listed at the appropriate intersections. Two generic analogue matrices have been developed, one for the near-field and one for the far-field. Combining analogue studies with field and laboratory investigations provides a powerful means of investigating the natural processes which will occur in the repository environment because the disadvantages of one method are balanced by the advantages of the other. In order to illustrate how analogues can contribute to build technologists confidence, examples for the three different roles of analogues are given. Analogue studies contribute to technologists confidence by increasing the understanding of processes that control the evolution of the repository system over time. Qualitative information from analogues is of

  14. MAFF monitoring of the terrestrial environment

    International Nuclear Information System (INIS)

    Sherlock, J.C.

    1993-01-01

    This paper addresses the food surveillance programme of the Ministry of Agriculture, Fisheries and Food (MAFF), in particular the Terrestrial Radioactivity Monitoring Programme (TRAMP) and the estimation of dietary intake of radionuclides. To define the surveillance programme the following issues need to be decided upon: 1) the type of food which should be analysed; 2) the nature of the contaminants which should be analysed; and 3) the geographical location from which the food samples should be taken. (author)

  15. Turnover of eroded soil organic carbon after deposition in terrestrial and aquatic environments

    DEFF Research Database (Denmark)

    Kirkels, Frédérique; Cammeraat, Erik; Kalbitz, Karsten

    cycling. However, the net effect on C fluxes between soils, inland waters and atmosphere remains uncertain. In this study, we determined SOC turnover in terrestrial and aquatic environments and indentified its major controls. A European gradient of agricultural sites was sampled, spanning a wide range...... soil properties (e.g. texture, aggregation, etc.), SOC quantity and quality. In a 16-week incubation experiment, SOC turnover was determined for conditions reflecting downslope soils or inland waters. Moreover, we studied the impact of labile C inputs (‘priming’) on SOC stability using 13C labeled...... cellulose. Physical and chemical soil properties and SOC molecular composition were assessed as potential controls on C turnover. SOC deposition in aquatic environments resulted in upto 3.5 times higher C turnover than deposition on downslope soils. Labile C inputs enlarged total CO2 emissions...

  16. Analogue Gravity

    Directory of Open Access Journals (Sweden)

    Barceló Carlos

    2005-12-01

    Full Text Available Analogue models of (and for gravity have a long and distinguished history dating back to the earliest years of general relativity. In this review article we will discuss the history, aims, results, and future prospects for the various analogue models. We start the discussion by presenting a particularly simple example of an analogue model, before exploring the rich history and complex tapestry of models discussed in the literature. The last decade in particular has seen a remarkable and sustained development of analogue gravity ideas, leading to some hundreds of published articles, a workshop, two books, and this review article. Future prospects for the analogue gravity programme also look promising, both on the experimental front (where technology is rapidly advancing and on the theoretical front (where variants of analogue models can be used as a springboard for radical attacks on the problem of quantum gravity.

  17. Nontoxic piperamides and their synthetic analogues as novel antifouling reagents

    KAUST Repository

    Huang, Xiang-Zhong

    2014-03-25

    Bioassay-guided isolation of an acetone extract from a terrestrial plant Piper betle produced four known piperamides with potent antifouling (AF) activities, as evidenced by inhibition of settlement of barnacle cypris larvae. The AF activities of the four piperamides and 15 synthesized analogues were compared and their structure-activity relationships were probed. Among the compounds, piperoleine B and 1-[1-oxo-7-(3′,4′-methylenedioxyphenyl)-6E-heptenyl]-piperidine (MPHP) showed strong activity against settlement of cyprids of the barnacle Balanus amphitrite, having EC50 values of 1.1 ± 0.3 and 0.5 ± 0.2 μg ml-1, respectively. No toxicity against zebra fish was observed following incubation with these two compounds. Besides being non-toxic, 91% of piperoleine B-treated cyprids and 84% of MPHP-treated cyprids at a concentration of 100 μM completed normal metamorphosis in recovery bioassays, indicating that the anti-settlement effect of these two compounds was reversible. Hydrolysis and photolysis experiments indicated that MPHP could be decomposed in the marine environment. It is concluded that piperamides are promising compounds for use in marine AF coatings. © 2014 © 2014 Taylor & Francis.

  18. Microplastics as an emerging threat to terrestrial ecosystems.

    Science.gov (United States)

    de Souza Machado, Anderson Abel; Kloas, Werner; Zarfl, Christiane; Hempel, Stefan; Rillig, Matthias C

    2018-04-01

    Microplastics (plastics plastic litter or from direct environmental emission. Their potential impacts in terrestrial ecosystems remain largely unexplored despite numerous reported effects on marine organisms. Most plastics arriving in the oceans were produced, used, and often disposed on land. Hence, it is within terrestrial systems that microplastics might first interact with biota eliciting ecologically relevant impacts. This article introduces the pervasive microplastic contamination as a potential agent of global change in terrestrial systems, highlights the physical and chemical nature of the respective observed effects, and discusses the broad toxicity of nanoplastics derived from plastic breakdown. Making relevant links to the fate of microplastics in aquatic continental systems, we here present new insights into the mechanisms of impacts on terrestrial geochemistry, the biophysical environment, and ecotoxicology. Broad changes in continental environments are possible even in particle-rich habitats such as soils. Furthermore, there is a growing body of evidence indicating that microplastics interact with terrestrial organisms that mediate essential ecosystem services and functions, such as soil dwelling invertebrates, terrestrial fungi, and plant-pollinators. Therefore, research is needed to clarify the terrestrial fate and effects of microplastics. We suggest that due to the widespread presence, environmental persistence, and various interactions with continental biota, microplastic pollution might represent an emerging global change threat to terrestrial ecosystems. © 2017 John Wiley & Sons Ltd.

  19. Diversity and population characteristics of terrestrial isopods (Crustacea, Oniscidea across three forest environments in southern Brazil

    Directory of Open Access Journals (Sweden)

    Priscila da Silva Bugs

    2014-09-01

    Full Text Available Terrestrial isopods are important and dominant component of meso and macrodecomposer soil communities. The present study investigates the diversity and species composition of terrestrial isopods on three forests on the Serra Geral of the state of Rio Grande do Sul, Brazil. The area has two natural formations (Primary Woodland and Secondary Woodland and one plantation of introduced Pinus. The pitfall traps operated from March 2001 to May 2002, with two summer periods and one winter. There were 14 sampling dates overall. Of the five species found: Alboscia silveirensis Araujo, 1999, Atlantoscia floridana (van Name, 1940, Benthana araucariana Araujo & Lopes, 2003 (Philoscidae, Balloniscus glaber Araujo & Zardo, 1995 (Balloniscidae and Styloniscus otakensis (Chilton, 1901 (Styloniscidae; only A. floridana is abundant on all environments and B. glaber is nearly exclusive for the native forests. The obtained data made it possible to infer about population characteristics of this species. The Similarity Analysis showed a quantitative difference among the Secondary forest and Pinus plantation, but not a qualitative one. The operational sex ratio (OSR analysis for A. floridana does not reveal significant differences in male and female proportions among environments. The reproductive period identified in the present study for A. floridana was from spring to autumn in the primary forest and Pinus plantation and during all year for the secondary forest. The OSR analysis for B. glaber reveals no significant differences in abundance between males and females for secondary forest, but the primary forest was a significant difference. The reproductive period for B. glaber extended from summer to autumn (for primary and secondary forest. This is the first record for Brazil of an established terrestrial isopod population in a Pinus sp. plantation area, evidenced by the presence of young, adults and ovigerous females, balanced sex ratio, expected fecundity and

  20. A preliminary feasibility study on natural analogue in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Chun Soo; Bae, Dae Seok; Kim, Kyung Su; Koh, Yong Kwon; Park, Byung Yun

    2000-03-01

    Preliminary study on the assessment of natural analogue study in Korea for the deep geological disposal of high-level radioactive waste was carried out. The project on natural analogue study in other countries are introduced. The uranium-bearing deposit in Okcheon belt are summarized, which reported to be uranium-bearing minerals in order to assess to feasibility for natural analogue study in Korea. Among the uranium-bearing deposits, the Deokpyeong area, reported to be the highest reservoir and grade, are selected as the study site, and the elementary investigation, including survey of radioactivity and geochemistry are carried out. According to the investigation of surface environment, the radioactivity and uranium content in the surface water and shallow groundwater does not show any anormal values. However, the radioactivity is expected to be increased in depth and the groundwater reacted with uranium-bearing graphite formation shows high unanium content, indicating the potential possibility for natural analogue study in Korea. In future, if more detail study are performed, the assessment of natural analogue study in Korea are expected.

  1. Community Decadal Panel for Terrestrial Analogs to Mars

    Science.gov (United States)

    Barlow, N. G.; Farr, T.; Baker, V. R.; Bridges, N.; Carsey, F.; Duxbury, N.; Gilmore, M. S.; Green, J. R.; Grin, E.; Hansen, V.; Keszthelyi, L.; Lanagan, P.; Lentz, R.; Marinangeli, L.; Morris, P. A.; Ori, G. G.; Paillou, P.; Robinson, C.; Thomson, B.

    2001-11-01

    It is well recognized that interpretations of Mars must begin with the Earth as a reference. The most successful comparisons have focused on understanding geologic processes on the Earth well enough to extrapolate to Mars' environment. Several facets of terrestrial analog studies have been pursued and are continuing. These studies include field workshops, characterization of terrestrial analog sites for Mars, instrument tests, laboratory measurements (including analysis of martian meteorites), and computer and laboratory modeling. The combination of all these activities allows scientists to constrain the processes operating in specific terrestrial environments and extrapolate how similar processes could affect Mars. The Terrestrial Analogs for Mars Community Panel is considering the following two key questions: (1) How do terrestrial analog studies tie in to the MEPAG science questions about life, past climate, and geologic evolution of Mars, and (2) How can future instrumentation be used to address these questions. The panel is considering the issues of data collection, value of field workshops, data archiving, laboratory measurements and modeling, human exploration issues, association with other areas of solar system exploration, and education and public outreach activities.

  2. Imprints to the terrestrial environment at galactic arm crossings of the solar system

    Science.gov (United States)

    Fahr, H. J.; Fichtner, H.; Scherer, K.; Stawicki, O.

    At its itinerary through our milky way galaxy the solar system moves through highly variable interstellar environments. Due to its orbital revolution around the galactic center, the solar system also crosses periodically the spiral arms of our galactic plane and thereby expe riences pronounced enviromental changes. Gas densities, magnetic fields and galactic cosmic ray intensities are substantially higher there compared to interarm conditions. Here we present theoretical calculations describing the SN-averaged galactic cosmic ray spectrum for regions inside and outside of galactic arms which then allow to predict how periodic passages of the solar system through galactic arms should be reflected by enhanced particle irradiations of the earth`s atmosphere and by correlated terrestrial Be-10 production rates.

  3. Scientific results and lessons learned from an integrated crewed Mars exploration simulation at the Rio Tinto Mars analogue site

    Science.gov (United States)

    Orgel, Csilla; Kereszturi, Ákos; Váczi, Tamás; Groemer, Gernot; Sattler, Birgit

    2014-02-01

    Between 15 and 25 April 2011 in the framework of the PolAres programme of the Austrian Space Forum, a five-day field test of the Aouda.X spacesuit simulator was conducted at the Rio Tinto Mars-analogue site in southern Spain. The field crew was supported by a full-scale Mission Control Center (MCC) in Innsbruck, Austria. The field telemetry data were relayed to the MCC, enabling a Remote Science Support (RSS) team to study field data in near-real-time and adjust the flight planning in a flexible manner. We report on the experiences in the field of robotics, geophysics (Ground Penetrating Radar) and geology as well as life sciences in a simulated spaceflight operational environment. Extravehicular Activity (EVA) maps had been prepared using Google Earth and aerial images. The Rio Tinto mining area offers an excellent location for Mars analogue simulations. It is recognised as a terrestrial Mars analogue site because of the presence of jarosite and related sulphates, which have been identified by the NASA Mars Exploration Rover "Opportunity" in the El Capitan region of Meridiani Planum on Mars. The acidic, high ferric-sulphate content water of Rio Tinto is also considered as a possible analogue in astrobiology regarding the analysis of ferric sulphate related biochemical pathways and produced biomarkers. During our Mars simulation, 18 different types of soil and rock samples were collected by the spacesuit tester. The Raman results confirm the presence of minerals expected, such as jarosite, different Fe oxides and oxi-hydroxides, pyrite and complex Mg and Ca sulphates. Eight science experiments were conducted in the field. In this contribution first we list the important findings during the management and realisation of tests, and also a first summary of the scientific results. Based on these experiences suggestions for future analogue work are also summarised. We finish with recommendations for future field missions, including the preparation of the experiments

  4. Salmon migration patterns revealed the temporal and spatial fluctuations of the radiocesium levels in terrestrial and ocean environments.

    Science.gov (United States)

    Arai, Takaomi

    2014-01-01

    The disabling of the Fukushima Daiichi Nuclear Power Plant (F1NPP) resulted in the release of radionuclides, including 134Cs and 137Cs, into the air and the ocean. The unpredicted nuclear accident is of global concern for human health and the ecosystem. Although investigations of radionuclides in environments were performed shortly after the accident started, the temporal and spatial impacts and fluctuations on the releasing radionuclides to natural environment remain unclear. I focused on salmon, which migrate from inland to the open ocean globally, to reveal the three-year (May 2011 to February 2014) fluctuations and accumulations of 134Cs and 137Cs from terrestrial to open ocean environments after the F1NPP accident. The 134Cs and 137Cs concentrations in six salmonids exhibited lower temporal variations for three years after the F1NPP accident, suggesting that these radionuclides are widely distributed and these radionuclides remain in the natural environment globally with less convergence. The accumulation patterns were significantly different among the different salmon species. Fluvial (freshwater residence) type salmons exhibited significantly higher accumulation in 134Cs (25.3-40.2 Bq kg(-1) in mean) and 137Cs (41.4-51.7 Bq kg(-1) in mean) than did the anadromous (sea-run) type salmons (0.64-8.03 Bq kg(-1) in mean 134Cs and 0.42-10.2 Bq kg(-1) in mean 137Cs) suggesting widespread contamination in terrestrial environments versus the coastal and open ocean environments. Salmonids are the most highly migratory animals and are characterised by their strong tendency to return home to their natal site for reproduction. Salmonids have a potential to be a good indicator as an effective monitoring animal.

  5. Commercialization of terrestrial applications of aerospace power technology

    International Nuclear Information System (INIS)

    Landsberg, D.R.

    1992-01-01

    The potential for commercialization of terrestrial energy systems based upon aerospace power technology's explored. Threats to the aerospace power technology industry, caused by the end of the cold war and weak world economy are described. There are also new opportunities caused by increasing terrestrial energy needs and world-wide concern for the environment. In this paper, the strengths and weaknesses of the aerospace power industry in commercializing terrestrial energy technologies are reviewed. Finally, actions which will enable the aerospace power technology industry to commercialize products into terrestrial energy markets are described

  6. Utilization of the terrestrial cyanobacteria

    Science.gov (United States)

    Katoh, Hiroshi; Tomita-Yokotani, Kaori; Furukawa, Jun; Kimura, Shunta; Yokoshima, Mika; Yamaguchi, Yuji; Takenaka, Hiroyuki

    The terrestrial, N _{2}-fixing cyanobacterium, Nostoc commune has expected to utilize for agriculture, food and terraforming cause of its extracellular polysaccharide, desiccation tolerance and nitrogen fixation. Previously, the first author indicated that desiccation related genes were analyzed and the suggested that the genes were related to nitrogen fixation and metabolisms. In this report, we suggest possibility of agriculture, using the cyanobacterium. Further, we also found radioactive compounds accumulated N. commune (cyanobacterium) in Fukushima, Japan after nuclear accident. Thus, it is investigated to decontaminate radioactive compounds from the surface soil by the cyanobacterium and showed to accumulate radioactive compounds using the cyanobacterium. We will discuss utilization of terrestrial cyanobacteria under closed environment. Keyword: Desiccation, terrestrial cyanobacteria, bioremediation, agriculture

  7. A novel lunar bed rest analogue.

    Science.gov (United States)

    Cavanagh, Peter R; Rice, Andrea J; Licata, Angelo A; Kuklis, Matthew M; Novotny, Sara C; Genc, Kerim O; Englehaupt, Ricki K; Hanson, Andrea M

    2013-11-01

    Humans will eventually return to the Moon and thus there is a need for a ground-based analogue to enable the study of physiological adaptations to lunar gravity. An important unanswered question is whether or not living on the lunar surface will provide adequate loading of the musculoskeletal system to prevent or attenuate the bone loss that is seen in microgravity. Previous simulations have involved tilting subjects to an approximately 9.5 degrees angle to achieve a lunar gravity component parallel to the long-axis of the body. However, subjects in these earlier simulations were not weight-bearing, and thus these protocols did not provide an analogue for load on the musculoskeletal system. We present a novel analogue which includes the capability to simulate standing and sitting in a lunar loading environment. A bed oriented at a 9.5 degrees angle was mounted on six linear bearings and was free to travel with one degree of freedom along rails. This allowed approximately 1/6 body weight loading of the feet during standing. "Lunar" sitting was also successfully simulated. A feasibility study demonstrated that the analogue was tolerated by subjects for 6 d of continuous bed rest and that the reaction forces at the feet during periods of standing were a reasonable simulation of lunar standing. During the 6 d, mean change in the volume of the quadriceps muscles was -1.6% +/- 1.7%. The proposed analogue would appear to be an acceptable simulation of lunar gravity and deserves further exploration in studies of longer duration.

  8. Anesthesia and critical-care delivery in weightlessness: A challenge for research in parabolic flight analogue space surgery studies

    Science.gov (United States)

    Ball, Chad G.; Keaney, Marilyn A.; Chun, Rosaleen; Groleau, Michelle; Tyssen, Michelle; Keyte, Jennifer; Broderick, Timothy J.; Kirkpatrick, Andrew W.

    2010-03-01

    BackgroundMultiple nations are actively pursuing manned exploration of space beyond low-earth orbit. The responsibility to improve surgical care for spaceflight is substantial. Although the use of parabolic flight as a terrestrial analogue to study surgery in weightlessness (0 g) is well described, minimal data is available to guide the appropriate delivery of anesthesia. After studying anesthetized pigs in a 0 g parabolic flight environment, our group developed a comprehensive protocol describing prolonged anesthesia in a parabolic flight analogue space surgery study (PFASSS). Novel challenges included a physically remote vivarium, prolonged (>10 h) anesthetic requirements, and the provision of veterinary operating room/intensive care unit (ICU) equivalency on-board an aircraft with physical dimensions of ethical approval, multiple ground laboratory sessions were conducted with combinations of anesthetic, pre-medication, and induction protocols on Yorkshire-cross specific pathogen-free (SPF) pigs. Several constant rate infusion (CRI) intravenous anesthetic combinations were tested. In each regimen, opioids were administered to ensure analgesia. Ventilation was supported mechanically with blended gradients of oxygen. The best performing terrestrial 1 g regime was flight tested in parabolic flight for its effectiveness in sustaining optimal and prolonged anesthesia, analgesia, and maintaining hemodynamic stability. Each flight day, a fully anesthetized, ventilated, and surgically instrumented pig was transported to the Flight Research Laboratory (FRL) in a temperature-controlled animal ambulance. A modular on-board surgical/ICU suite with appropriate anesthesia/ICU and surgical support capabilities was employed. ResultsThe mean duration of anesthesia (per flight day) was 10.28 h over four consecutive days. A barbiturate and ketamine-based CRI anesthetic regimen supplemented with narcotic analgesia by bolus administration offered the greatest prolonged hemodynamic

  9. Analogue MIMO Detection

    Directory of Open Access Journals (Sweden)

    McNamara Darren

    2006-01-01

    Full Text Available In this contribution we propose an analogue receiver that can perform turbo detection in MIMO systems. We present the case for a receiver that is built from nonlinear analogue devices, which perform detection in a "free-flow" network (no notion of iterations. This contribution can be viewed as an extension of analogue turbo decoder concepts to include MIMO detection. These first analogue implementations report reductions of few orders of magnitude in the number of required transistors and in consumed energy, and the same order of improvement in processing speed. It is anticipated that such analogue MIMO decoder could bring about the same advantages, when compared to traditional digital implementations.

  10. The Circumpolar Biodiversity Monitoring Program Terrestrial Plan

    DEFF Research Database (Denmark)

    Christensen, Tom; Payne, J.; Doyle, M.

    , understand and report on long-term change in Arctic terrestrial ecosystems and biodiversity, and to identify knowledge gaps and priorities. This poster will outline the key management questions the plan aims to address and the proposed nested, multi-scaled approach linking targeted, research based monitoring...... and coastal environments. The CBMP Terrestrial Plan is a framework to focus and coordinate monitoring of terrestrial biodiversity across the Arctic. The goal of the plan is to improve the collective ability of Arctic traditional knowledge (TK) holders, northern communities, and scientists to detect...

  11. Environmental aspects: - Atmospheric, - aquatic, - terrestrial dispersion of radionuclides

    International Nuclear Information System (INIS)

    Kirchmann, R.

    1982-01-01

    After general introductory remarks the paper deals with the dispersion of radionuclides in the atmosphere and in the aquatic environment as well as with the transfer through the terrestrial environment. (RW)

  12. Subject-3: Study on migration of radionuclides released into terrestrial and aquatic environment after nuclear accident

    International Nuclear Information System (INIS)

    Amano, H.; Matsunaga, T.; Ueno, T.; Nagao, S.; Yanase, N.; Tkachenko, Yu.

    2001-01-01

    Subject-3 has been focused on the migration behavior of long-lived radionuclides in the terrestrial surface environment, especially in connection with their chemical and physical forms. Migration behavior of radionuclides is strongly affected with their chemical and physical forms (for example; Gunten and Benes 1995). One of the two categories in Subject-3 consists of migration from surface soils including aging effects of hot particles, plant uptake from contaminated soils, and resuspension of radionuclides. The other is run off by river system, considering the role of organic materials. (author)

  13. Subject-3: Study on migration of radionuclides released into terrestrial and aquatic environment after nuclear accident

    Energy Technology Data Exchange (ETDEWEB)

    Amano, H.; Matsunaga, T.; Ueno, T.; Nagao, S.; Yanase, N. [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Arkhipov, A.N. [Chernobyl Scientific and Technical Center for International Research (Ukraine); Tkachenko, Yu. [The State Enterprise Regional Monitoring and Domestic Control (RADEC) (Unknown)

    2001-03-01

    Subject-3 has been focused on the migration behavior of long-lived radionuclides in the terrestrial surface environment, especially in connection with their chemical and physical forms. Migration behavior of radionuclides is strongly affected with their chemical and physical forms (for example; Gunten and Benes 1995). One of the two categories in Subject-3 consists of migration from surface soils including aging effects of hot particles, plant uptake from contaminated soils, and resuspension of radionuclides. The other is run off by river system, considering the role of organic materials. (author)

  14. Preliminary study of the 129I distribution in environment of La Hague reprocessing plant with the help of a terrestrial moss: Homalotecium sericeum. Study report

    International Nuclear Information System (INIS)

    1999-01-01

    The preliminary study of the 129 I distribution has allowed to underline the limits of use of a Homalotecium sericeum type terrestrial moss as biological indicator. However, this preliminary study allowed all the same to give a spatial distribution of this radioelement around La Hague reprocessing plant (source term) that underlines the existence of four geographic areas in function of collected activities. The levels are generally under 99 Bq/kg dry. It is recommended to improve the knowledge that we can have of transfers and quantity of iodine 129 from the marine environment to the terrestrial environment, but also, the one that we can have of factors able to modify the spatial distribution of this radionuclide. (N.C.)

  15. Working group 4: Terrestrial

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    A working group at a Canada/USA symposium on climate change and the Arctic identified major concerns and issues related to terrestrial resources. The group examined the need for, and the means of, involving resource managers and users at local and territorial levels in the process of identifying and examining the impacts and consequences of climatic change. Climatic change will be important to the Arctic because of the magnitude of the change projected for northern latitudes; the apparent sensitivity of its terrestrial ecosystems, natural resources, and human support systems; and the dependence of the social, cultural, and economic welfare of Arctic communities, businesses, and industries on the health and quality of their environment. Impacts of climatic change on the physical, biological, and associated socio-economic environment are outlined. Gaps in knowledge needed to quantify these impacts are listed along with their relationships with resource management. Finally, potential actions for response and adaptation are presented

  16. Environmental radionuclides tracers and timers of terrestrial processes

    CERN Document Server

    Froehlich, Klaus

    2009-01-01

    The book presents a state-of-the-art summary of knowledge on the use of radionuclides to study processes and systems in the continental part of the Earth's environment. It is conceived as a companion to the two volumes of this series, which deal with isotopes as tracers in the marine environment (Livingston, Marine Radioactivity) and with the radioecology of natural and man-made terrestrial systems (Shaw, Radioactivity in Terrestrial Ecosystems). Although the book focuses on natural and anthropogenic radionuclides (radioactive isotopes), it also refers to stable environmental isotopes, which i

  17. Variation of Geochemical Signatures and Correlation of Biomarkers in Icelandic Mars Analogue Environments

    Science.gov (United States)

    Gentry, D.; Amador, E. S.; Cable, M. L.; Cantrell, T.; Chaudry, N.; Cullen, T.; Duca, Z. A.; Jacobsen, M. B.; McCaig, H. C.; Murukesan, G.; Rennie, V.; Schwieterman, E. W.; Stevens, A. H.; Tan, G.; Yin, C.; Stockton, A.; Cullen, D.; Geppert, W.

    2015-12-01

    Exploration missions to Mars rely on rovers to perform deep analyses over small sampling areas; however, landing site selection is done using large-scale but low-resolution remote sensing data. Using Earth analogue environments to estimate the small-scale spatial and temporal distributions of key geochemical signatures and (for habitability studies) biomarkers helps ensure that the chosen sampling strategies meet mission science goals. We conducted two rounds of analogue expeditions to recent Icelandic lava fields. In July 2013, we tested correlation between three common biomarker assays: cell quantification via fluorescence microscopy, ATP quantification via bioluminescence, and quantitative PCR with universal primer sets. Sample sites were nested at four spatial scales (1 m, 10 m, 100 m, and > 1 km) and homogeneous at 'remote imaging' resolution (overall temperature, apparent moisture content, and regolith grain size). All spatial scales were highly diverse in ATP, bacterial 16S, and archaeal 16S DNA content; nearly half of sites were statistically different in ATP content at α = 0.05. Cell counts showed significant variation at the 10 m and 100 m scale; at the > 1 km scale, the mean counts were not distinguishable, but the median counts were, indicating differences in underlying distribution. Fungal 18S DNA content similarly varied at 1 m, 10 m, and 100 m scales only. Cell counts were not correlated with ATP or DNA content at any scale. ATP concentration and DNA content for all three primer sets were positively correlated. Bacterial DNA content was positively correlated with archaeal and fungal DNA content, though archaeal correlation was weak. Fungal and archaeal correlation was borderline. In July 2015, we repeated the sampling strategy, with the addition of a smaller-scale sampling grid of 10 cm and a third > 1 km location. This expedition also measured reflectance of the tephra cover and preserved mineral samples for future Raman spectroscopy in order to

  18. Origin and evolution of life on terrestrial planets.

    Science.gov (United States)

    Brack, A; Horneck, G; Cockell, C S; Bérces, A; Belisheva, N K; Eiroa, Carlos; Henning, Thomas; Herbst, Tom; Kaltenegger, Lisa; Léger, Alain; Liseau, Réne; Lammer, Helmut; Selsis, Franck; Beichman, Charles; Danchi, William; Fridlund, Malcolm; Lunine, Jonathan; Paresce, Francesco; Penny, Alan; Quirrenbach, Andreas; Röttgering, Huub; Schneider, Jean; Stam, Daphne; Tinetti, Giovanna; White, Glenn J

    2010-01-01

    The ultimate goal of terrestrial planet-finding missions is not only to discover terrestrial exoplanets inside the habitable zone (HZ) of their host stars but also to address the major question as to whether life may have evolved on a habitable Earth-like exoplanet outside our Solar System. We note that the chemical evolution that finally led to the origin of life on Earth must be studied if we hope to understand the principles of how life might evolve on other terrestrial planets in the Universe. This is not just an anthropocentric point of view: the basic ingredients of terrestrial life, that is, reduced carbon-based molecules and liquid H(2)O, have very specific properties. We discuss the origin of life from the chemical evolution of its precursors to the earliest life-forms and the biological implications of the stellar radiation and energetic particle environments. Likewise, the study of the biological evolution that has generated the various life-forms on Earth provides clues toward the understanding of the interconnectedness of life with its environment.

  19. Analysis by Monte Carlo simulations of the sensitivity to single event upset of SRAM memories under spatial proton or terrestrial neutron environment

    International Nuclear Information System (INIS)

    Lambert, D.

    2006-07-01

    Electronic systems in space and terrestrial environments are subjected to a flow of particles of natural origin, which can induce dysfunctions. These particles can cause Single Event Upsets (SEU) in SRAM memories. Although non-destructive, the SEU can have consequences on the equipment functioning in applications requiring a great reliability (airplane, satellite, launcher, medical, etc). Thus, an evaluation of the sensitivity of the component technology is necessary to predict the reliability of a system. In atmospheric environment, the SEU sensitivity is mainly caused by the secondary ions resulting from the nuclear reactions between the neutrons and the atoms of the component. In space environment, the protons with strong energies induce the same effects as the atmospheric neutrons. In our work, a new code of prediction of the rate of SEU has been developed (MC-DASIE) in order to quantify the sensitivity for a given environment and to explore the mechanisms of failures according to technology. This code makes it possible to study various technologies of memories SRAM (Bulk and SOI) in neutron and proton environment between 1 MeV and 1 GeV. Thus, MC-DASIE was used with experiment data to study the effect of integration on the sensitivity of the memories in terrestrial environment, a comparison between the neutron and proton irradiations and the influence of the modeling of the target component on the calculation of the rate of SEU. (author)

  20. Ontogenetic shifts in terrestrial reliance of stream-dwelling brown trout

    Directory of Open Access Journals (Sweden)

    Javier Sánchez-Hernández

    2016-07-01

    Full Text Available This study focuses on terrestrial reliance of brown trout (Salmo trutta and compared it to the potential prey available (macrozoobenthos and drifting invertebrates in three temperate rivers (Galicia, NW Spain, with special emphasis on variations in terrestrial energy intake through the ontogeny of brown trout. Additionally, we paid particular attention to individual variation of terrestrial resource use within and between age classes. Prey items were grouped in four categories: i aquatic invertebrates; ii imagoes of aquatic invertebrates; iii terrestrial invertebrates; and iv fish prey. Next, energy composition was measured according to dry weight-energy equations for each individual in line with above-mentioned prey categories. Our findings illustrate that terrestrial invertebrates appeared to be scarce in the environment, whereas aquatic food resources were rather abundant and accessible. The use of terrestrial invertebrates tended to increase with age, but with a high degree of inter-individual variation in resource use. In fact, the individual reliance of brown trout on terrestrial invertebrates may vary considerably (between 0% and 76.9%. Besides, the frequency of terrestrial foragers, i.e., individuals with terrestrial invertebrates in their stomachs, increased with age, except in one population which had the maximum value in the age-2 class. The acquisition of terrestrial invertebrates thus appears to be a process strongly dependent upon the actual food availability in the environment, but with a high degree of individual variance in resource use within the same age class. Finally, we discuss that terrestrial invertebrates may largely contribute to cover the energy intake of the species, highlighting the interface between terrestrial and aquatic ecosystems, and thereby the importance of riparian canopy cover as a key factor for food supply of stream-dwelling salmonids species.

  1. Natural analogues, paradigm for manmade repositories for radioactive wastes

    International Nuclear Information System (INIS)

    Pavelescu, M.; Pavelescu, A.

    2004-01-01

    Natural analogues are given by nature. They show the results of natural processes which have lasted thousands or millions of years. They provide an excellent example of what could happen in an underground site, offering in the same time the opportunity to test by observation and measurement, many of the geochemical processes that are expected to influence in a realistic and appropriate way, the predicted reliability of the radioactive waste repository over long periods of geological time. The natural analogue studies attempt to understand the multiprocessing complexity of the natural system, which contrasts with the limitations of the laboratory experiments and bring arguments to overcome the difficult time scale issue. By this the natural analogues are a useful paradigm for manmade repository for radioactive wastes. The paper discusses the implicit link in the public mind between natural analogues and manmade waste repository with an accent of the positive impact on public acceptance. It is also discussed the decisive qualities of the natural analogues concerning providing valid long term data and increasing the confidence of the public for manmade repositories. The debate is conducting in terms of sustainable development, having at base high-level principles in order to protect humans and their environment, both now and in the future, from potential hazards arising from such wastes. Safe radwaste management involves the application of technology and resources in a regulated manner so that the public, workers and the environment are protected in accordance with the accepted national and international standards. There are at least seven high-level principles which are mentioned in the paper. It is presented the general concept of the deep geological repository, very important for an acceptable solution for the management of nuclear waste, what is a prerequisite for a renewal of nuclear power. Further are introduced natural and archaeological (manufactured) analogue

  2. Comparison of PFASs contamination in the freshwater and terrestrial environments by analysis of eggs from osprey (Pandion haliaetus), tawny owl (Strix aluco), and common kestrel (Falco tinnunculus)

    International Nuclear Information System (INIS)

    Eriksson, Ulrika; Roos, Anna; Lind, Ylva; Hope, Kjell; Ekblad, Alf; Kärrman, Anna

    2016-01-01

    The level of PFAS (per- and polyfluorinated alkyl substances) contamination in freshwater and terrestrial Swedish environments in 2013/2014 was assessed by analyzing a range of perfluorinated alkyl acids, fluorotelomer acids, sulfonamides, sulfonamidoethanols and polyfluoralkyl phosphate diesters (diPAPs) in predator bird eggs. Stable isotopes ( 13 C and 15 N) were analyzed to elucidate the dietary source. The tawny owl (Strix aluco, n=10) and common kestrel (Falco tinnunculus, n=40), two terrestrial species, and the osprey (Pandion haliaetus, n=30), a freshwater specie were included. In addition, a temporal trend (1997–2001, 2008–2009, 2013) in osprey was studied as well. The PFAS profile was dominated by perfluorooctane sulfonic acid (PFOS) in eggs from osprey and tawny owl, while for common kestrel perfluorinated carboxylic acids (∑PFCA) exceeded the level of PFOS. PFOS concentration in osprey eggs remained at the same level between 1997 and 2001 and 2013. For the long-chained PFCAs, there were a significant increase in concentrations in osprey eggs between 1997 and 2001 and 2008–2009. The levels of PFOS and PFCAs were about 10 and five times higher, respectively, in osprey compared to tawny owl and common kestrel. Evidence of direct exposure from PFCA precursor compounds to birds in both freshwater and terrestrial environment was observed. Low levels of diPAPs were detected in a few samples of osprey (<0.02–2.4 ng/g) and common kestrel (<0.02–0.16 ng/g) eggs, and 6:2 FTSA was detected in a majority of the osprey eggs (<6.3–52 ng/g). One saturated telomer acid (7:3 FTCA), which is a transformation marker from precursor exposure, was detected in all species (<0.24–2.7 ng/g). The 15 N data showed higher levels in osprey eggs compared to tawny owl and common kestrel, indicating that they feed on a 2–3 times higher trophic level. We conclude that ospreys are continuously exposed to PFAS at levels where adverse toxic effects have been observed in

  3. Comparison of PFASs contamination in the freshwater and terrestrial environments by analysis of eggs from osprey (Pandion haliaetus), tawny owl (Strix aluco), and common kestrel (Falco tinnunculus)

    Energy Technology Data Exchange (ETDEWEB)

    Eriksson, Ulrika, E-mail: ulrika.eriksson@oru.se [Man-Technology-Environment (MTM) Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro (Sweden); Roos, Anna; Lind, Ylva [Swedish Museum of Natural History, P.O. Box 50007, SE-104 05 Stockholm (Sweden); Hope, Kjell; Ekblad, Alf; Kärrman, Anna [Man-Technology-Environment (MTM) Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro (Sweden)

    2016-08-15

    The level of PFAS (per- and polyfluorinated alkyl substances) contamination in freshwater and terrestrial Swedish environments in 2013/2014 was assessed by analyzing a range of perfluorinated alkyl acids, fluorotelomer acids, sulfonamides, sulfonamidoethanols and polyfluoralkyl phosphate diesters (diPAPs) in predator bird eggs. Stable isotopes ({sup 13}C and {sup 15}N) were analyzed to elucidate the dietary source. The tawny owl (Strix aluco, n=10) and common kestrel (Falco tinnunculus, n=40), two terrestrial species, and the osprey (Pandion haliaetus, n=30), a freshwater specie were included. In addition, a temporal trend (1997–2001, 2008–2009, 2013) in osprey was studied as well. The PFAS profile was dominated by perfluorooctane sulfonic acid (PFOS) in eggs from osprey and tawny owl, while for common kestrel perfluorinated carboxylic acids (∑PFCA) exceeded the level of PFOS. PFOS concentration in osprey eggs remained at the same level between 1997 and 2001 and 2013. For the long-chained PFCAs, there were a significant increase in concentrations in osprey eggs between 1997 and 2001 and 2008–2009. The levels of PFOS and PFCAs were about 10 and five times higher, respectively, in osprey compared to tawny owl and common kestrel. Evidence of direct exposure from PFCA precursor compounds to birds in both freshwater and terrestrial environment was observed. Low levels of diPAPs were detected in a few samples of osprey (<0.02–2.4 ng/g) and common kestrel (<0.02–0.16 ng/g) eggs, and 6:2 FTSA was detected in a majority of the osprey eggs (<6.3–52 ng/g). One saturated telomer acid (7:3 FTCA), which is a transformation marker from precursor exposure, was detected in all species (<0.24–2.7 ng/g). The {sup 15}N data showed higher levels in osprey eggs compared to tawny owl and common kestrel, indicating that they feed on a 2–3 times higher trophic level. We conclude that ospreys are continuously exposed to PFAS at levels where adverse toxic effects have been

  4. Ancient Terrestrial Carbon: Lost and Found

    Science.gov (United States)

    Freeman, K. H.

    2017-12-01

    Carbon fluxes in terrestrial environments dominate the global carbon cycle. The fluxes of terrestrial carbon are strongly tied to regional climate due to the influences of temperature, water, and nutrient dynamics on plant productivity. However, climate also influences the destruction of terrestrial organic matter, through weathering, erosion, and biomass loss via fire and oxidative microbial processes. Organic geochemical methods enable us to interrogate past terrestrial carbon dynamics and learn how continental processes might accelerate, or mitigate carbon transfer to the atmosphere, and the associated greenhouse warming. Terrestrial soil systems represent the weathering rind of the continents, and are inherently non-depositional and erosive. The production, transport, and depositional processes affecting organics in continental settings each impart their own biases on the amount and characteristics of preserved carbon. Typically, the best archives for biomarker records are sediments in ancient lakes or subaqueous fans, which represents a preservation bias that tends to favor wetter environments. Paleosols, or ancient soils, formed under depositional conditions that, for one reason or another, truncated soil ablation, erosion, or other loss processes. In modern soils, widely ranging organic carbon abundances are almost always substantially greater than the trace amounts of carbon left behind in ancient soils. Even so, measureable amounts of organic biomarkers persist in paleosols. We have been investigating processes that preserve soil organic carbon on geologic timescales, and how these mechanisms may be sensitive to past climate change. Climate-linked changes in temperature, moisture, pH, and weathering processes can impact carbon preservation via organo-mineral sorption, soil biogeochemistry, and stability based on the physical and chemical properties of organic compounds. These will be discussed and illustrated with examples from our studies of Cenozoic

  5. TAME - the terrestrial-aquatic model of the environment: model definition

    International Nuclear Information System (INIS)

    Klos, R.A.; Mueller-Lemans, H.; Dorp, F. van; Gribi, P.

    1996-10-01

    TAME - the Terrestrial-Aquatic Model of the Environment is a new computer model for use in assessments of the radiological impact of the release of radionuclides to the biosphere, following their disposal in underground waste repositories. Based on regulatory requirements, the end-point of the calculations is the maximum annual individual dose to members of a hypothetical population group inhabiting the biosphere region. Additional mid- and end-points in the TAME calculations are dose as function of time from eleven exposure pathways, foodstuff concentrations and the distribution of radionuclides in the modelled biosphere. A complete description of the mathematical representations of the biosphere in TAME is given in this document, based on a detailed review of the underlying conceptual framework for the model. Example results are used to illustrate features of the conceptual and mathematical models. The end-point of dose is shown to be robust for the simplifying model assumptions used to define the biosphere for the example calculations. TAME comprises two distinct sub-models - one representing the transport of radionuclides in the near-surface environment and one for the calculation of dose to individual inhabitants of that biosphere. The former is the result of a detailed review of the modelling requirements for such applications and is based on a comprehensive consideration of all features, events and processes (FEPs) relevant to Swiss biospheres, both in the present-day biosphere and in potential future biosphere states. Representations of the transport processes are derived from first principles. Mass balance for water and solid material fluxes is used to determine the rates of contaminant transfer between components of the biosphere system. The calculation of doses is based on existing representations of exposure pathways and draws on experience both from Switzerland and elsewhere. (author) figs., tabs., refs

  6. TAME - the terrestrial-aquatic model of the environment: model definition

    Energy Technology Data Exchange (ETDEWEB)

    Klos, R.A. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Mueller-Lemans, H. [Tergoso AG fuer Umweltfragen, Sargans (Switzerland); Dorp, F. van [Nationale Genossenschaft fuer die Lagerung Radioaktiver Abfaelle (NAGRA), Baden (Switzerland); Gribi, P. [Colenco AG, Baden (Switzerland)

    1996-10-01

    TAME - the Terrestrial-Aquatic Model of the Environment is a new computer model for use in assessments of the radiological impact of the release of radionuclides to the biosphere, following their disposal in underground waste repositories. Based on regulatory requirements, the end-point of the calculations is the maximum annual individual dose to members of a hypothetical population group inhabiting the biosphere region. Additional mid- and end-points in the TAME calculations are dose as function of time from eleven exposure pathways, foodstuff concentrations and the distribution of radionuclides in the modelled biosphere. A complete description of the mathematical representations of the biosphere in TAME is given in this document, based on a detailed review of the underlying conceptual framework for the model. Example results are used to illustrate features of the conceptual and mathematical models. The end-point of dose is shown to be robust for the simplifying model assumptions used to define the biosphere for the example calculations. TAME comprises two distinct sub-models - one representing the transport of radionuclides in the near-surface environment and one for the calculation of dose to individual inhabitants of that biosphere. The former is the result of a detailed review of the modelling requirements for such applications and is based on a comprehensive consideration of all features, events and processes (FEPs) relevant to Swiss biospheres, both in the present-day biosphere and in potential future biosphere states. Representations of the transport processes are derived from first principles. Mass balance for water and solid material fluxes is used to determine the rates of contaminant transfer between components of the biosphere system. The calculation of doses is based on existing representations of exposure pathways and draws on experience both from Switzerland and elsewhere. (author) figs., tabs., refs.

  7. Amphibious fish jump better on land after acclimation to a terrestrial environment.

    Science.gov (United States)

    Brunt, Emily M; Turko, Andy J; Scott, Graham R; Wright, Patricia A

    2016-10-15

    Air and water differ dramatically in density and viscosity, posing different biomechanical challenges for animal locomotion. We asked how terrestrial acclimation influences locomotion in amphibious fish, specifically testing the hypothesis that terrestrial tail flip performance is improved by plastic changes in the skeletal muscle. Mangrove rivulus Kryptolebias marmoratus, which remain largely inactive out of water, were exposed to water or air for 14 days and a subgroup of air-exposed fish was also recovered in water. Tail flip jumping performance on land improved dramatically in air-acclimated fish, they had lower lactate levels compared with control fish, and these effects were mostly reversible. Muscle plasticity significantly increased oxidative muscle cross-sectional area and fibre size, as well as the number of capillaries per fibre. Our results show that reversible changes to the oxidative skeletal muscle of K. marmoratus out of water enhance terrestrial locomotory performance, even in the absence of exercise training. © 2016. Published by The Company of Biologists Ltd.

  8. Selection of passerine birds as bio-sentinel of persistent organic pollutants in terrestrial environment.

    Science.gov (United States)

    Mo, Ling; Zheng, Xiaobo; Sun, Yuxin; Yu, Lehuan; Luo, Xiaojun; Xu, Xiangrong; Qin, Xiaoquan; Gao, Yongli; Mai, Bixian

    2018-08-15

    A broad suite of persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and dichlorodiphenyltrichloroethane (DDT) and its metabolites, were analyzed in pectoral muscle of eight terrestrial passerine bird species from an extensive e-waste recycling site in South China. Concentrations of PCBs, PBDEs, and DDTs in bird samples ranged from 1260-279,000, 121-14,200, and 31-7910ng/g lipid weight, respectively. Insectivorous birds had significantly higher levels of PCBs, PBDEs, and DDTs than those in granivorous birds. Concentrations of POPs in resident insectivorous birds were significantly greater than those in migrant insectivorous birds. PCBs were the predominant pollutants in all bird species from the e-waste site, followed by PBDEs and DDTs, indicating that PCBs were mainly derived from e-wastes. The granivorous birds had higher proportions of hepta-CBs in total PCBs and higher proportions of octa- to deca-BDEs in total PBDEs compared with the insectivorous birds. The various dietary sources, migration behavior, and possible biotransformation were suspected as reasons of the distinct profiles of POPs in different bird species. The δ 15 N values were significantly and positively correlated with concentrations of POPs in resident insectivorous birds, but not in other passerine bird species, suggesting the influence of trophic levels on bioaccumulation of POPs in resident insectivorous birds. The resident insectivorous birds seem to be promising bio-sentinel of POPs in terrestrial environment around the e-waste sites. Copyright © 2018 Elsevier B.V. All rights reserved.

  9. Actinide elements in aquatic and terrestrial environments

    International Nuclear Information System (INIS)

    Bondietti, E.A.

    1978-01-01

    Progress is reported in terrestrial ecology studies with regard to plutonium in biota from the White Oak Creek forest; comparative distribution of plutonium in two forest ecosystems; an ecosystem model of plutonium dynamics; actinide element metabolism in cotton rats; and crayfish studies. Progress is reported in aquatic studies with regard to transuranics in surface waters, frogs, benthic algae, and invertebrates from pond 3513; and radioecology of transuranic elements in cotton rats bordering waste pond 3513. Progress is also reported in stability of trivalent plutonium in White Oak Lake water; chemistry of plutonium, americium, curium, and uranium in pond water; uranium, thorium, and plutonium in small mammals; and effect of soil pretreatment on the distribution of plutonium

  10. Abiotic Formation of Methyl Halides in the Terrestrial Environment

    Science.gov (United States)

    Keppler, F.

    2011-12-01

    Methyl chloride and methyl bromide are the most abundant chlorine and bromine containing organic compounds in the atmosphere. Since both compounds have relatively long tropospheric lifetimes they can effectively transport halogen atoms from the Earth's surface, where they are released, to the stratosphere and following photolytic oxidation form reactive halogen gases that lead to the chemical destruction of ozone. Methyl chloride and methyl bromide account for more than 20% of the ozone-depleting halogens delivered to the stratosphere and are predicted to grow in importance as the chlorine contribution to the stratosphere from anthropogenic CFCs decline. Today methyl chloride and methyl bromide originate mainly from natural sources with only a minor fraction considered to be of anthropogenic origin. However, until as recently as 2000 most of the methyl chloride and methyl bromide input to the atmosphere was considered to originate from the oceans, but investigations in recent years have clearly demonstrated that terrestrial sources such as biomass burning, wood-rotting fungi, coastal salt marshes, tropical vegetation and organic matter degradation must dominate the atmospheric budgets of these trace gases. However, many uncertainties still exist regarding strengths of both sources and sinks, as well as the mechanisms of formation of these naturally occurring halogenated gases. A better understanding of the atmospheric budget of both methyl chloride and methyl bromide is therefore required for reliable prediction of future ozone depletion. Biotic and abiotic methylation processes of chloride and bromide ion are considered to be the dominant pathways of formation of these methyl halides in nature. In this presentation I will focus on abiotic formation processes in the terrestrial environment and the potential parameters that control their emissions. Recent advances in our understanding of the abiotic formation pathway of methyl halides will be discussed. This will

  11. Evaluation of carbon-14 (C14) levels of terrestrial and marine food products of the environment of the site of Cogema La Hague

    International Nuclear Information System (INIS)

    2006-04-01

    This evaluation has for object to inform about the levels in carbon 14 in the environment of the factories of La Hague. Two sectors were differentiated on one hand the terrestrial environment, and on the other hand the marine environment. The investigations concerned first and foremost food products stemming as the vegetable culture (vegetables) or individual breeding (milk, eggs) but also foodstuffs stemming from the local agriculture (cereal). In touch with the second sector, the marine environment, the sampling concerned the accessible products of the sea by all and those locally marketed (fishes, molluscs, shellfishes). The different results are presented in tables. (N.C.)

  12. Efficacy of Antimicrobials on Bacteria Cultured in a Spaceflight Analogue

    Science.gov (United States)

    Nickerson, CA; Wotring, Virginia; Barrila, Jennifer; Crabbe, Aurelie; Castro, Sarah; Davis, Richard; Rideout, April; McCarthy, Breanne; Ott, C. Mark

    2014-01-01

    As humans travel in space, they will interact with microbial flora from themselves, other crewmembers, their food, and the environment. While evaluations of microbial ecology aboard the Mir and ISS suggest a predominance of common environmental flora, the presence of (and potential for) infectious agents has been well documented. Likewise, pathogens have been detected during preflight monitoring of spaceflight food, resulting in the disqualification of that production lot from flight. These environmental and food organisms range from the obligate pathogen, Salmonella enterica serovar Typhimurium (S. Typhimurium), which has been responsible for disqualification and removal of food destined for ISS and has previously been reported from Shuttle crew refuse, to the opportunistic pathogen Staphylococcus aureus, isolated numerous times from ISS habitable compartments and the crew. Infectious disease events have affected spaceflight missions, including an upper respiratory infection that delayed the launch of STS-36 and an incapacitating Pseudomonas aeruginosa urinary tract infection of a crewmember during Apollo 13. These observations indicate that the crew has the potential to be exposed to obligate and opportunistic pathogens. This risk of exposure is expected to increase with longer mission durations and increased use of regenerative life support systems. As antibiotics are the primary countermeasure after infection, determining if their efficacy during spaceflight missions is comparable to terrestrial application is of critical importance. The NASA Rotating Wall Vessel (RWV) culture system has been successfully used as a spaceflight culture analogue to identify potential alterations in several key microbial characteristics, such as virulence and gene regulation, in response to spaceflight culture. We hypothesized that bacteria cultured in the low fluid shear RWV environment would demonstrate changes in efficacy of antibiotics compared to higher fluid shear controls

  13. Subglacial hydrothermal alteration minerals in Jökulhlaup deposits of Southern Iceland, with implications for detecting past or present habitable environments on Mars.

    Science.gov (United States)

    Warner, Nicholas H; Farmer, Jack D

    2010-06-01

    Jökulhlaups are terrestrial catastrophic outfloods, often triggered by subglacial volcanic eruptions. Similar volcano-ice interactions were likely important on Mars where magma/lava may have interacted with the planet's cryosphere to produce catastrophic floods. As a potential analogue to sediments deposited during martian floods, the Holocene sandurs of Iceland are dominated by basaltic clasts derived from the subglacial environment and deposited during jökulhlaups. Palagonite tuffs and breccias, present within the deposits, represent the primary alteration lithology. The surface abundance of palagonite on the sandurs is 1-20%. X-ray diffraction (XRD) analysis of palagonite breccias confirms a mineral assemblage of zeolites, smectites, low-quartz, and kaolinite. Oriented powder X-ray diffractograms (habitable environments for microbial life may be found.

  14. Terrestrial Analogs to Mars: NRC Community Panel Decadal Report

    Science.gov (United States)

    Farr, T. G.

    2002-12-01

    A report was completed recently by a Community Panel for the NRC Decadal Study of Solar System Exploration. The desire was for a review of the current state of knowledge and for recommendations for action over the next decade. The topic of this panel, Terrestrial Analogs to Mars, was chosen to bring attention to the need for an increase in analog studies in support of the increased pace of Mars exploration. It is well recognized that interpretations of Mars must begin with the Earth as a reference. The most successful comparisons have focused on understanding geologic processes on the Earth well enough to extrapolate to Mars' environment. Several facets of terrestrial analog studies have been pursued and are continuing. These studies include field workshops, characterization of terrestrial analog sites, instrument tests, laboratory measurements (including analysis of martian meteorites), and computer and laboratory modeling. The combination of all of these activities allows scientists to constrain the processes operating in specific terrestrial environments and extrapolate how similar processes could affect Mars. The Terrestrial Analogs for Mars Community Panel has considered the following two key questions: (1) How do terrestrial analog studies tie in to the overarching science questions about life, past climate, and geologic evolution of Mars, and (2) How can future instrumentation be used to address these questions. The panel considered the issues of data collection and archiving, value of field workshops, laboratory measurements and modeling, human exploration issues, association with other areas of solar system exploration, and education and public outreach activities. Parts of this work were performed under contract to NASA.

  15. SAR mapping of Burfellshraun: A terrestrial analog for recent volcanism on Mars

    DEFF Research Database (Denmark)

    Haack, Henning; Rossi, Matti; Dall, Jørgen

    2006-01-01

    between 10 and 100 Myr. Parts of the lava flows show smooth kilometer-sized plates that appear to have rafted on the moving lava flow. We have found a terrestrial analogue with similar features, the Burfellshraun lava flow in Northern Iceland. This is the only known lava flow on Earth where kilometer......-sized rafting plates are observed and constitute the dominating feature. Using a combination of airborne remote sensing data and field observations we have studied the emplacement and physical properties of the flow. On the basis of our observations we have reconstructed the sequence of events that led...

  16. Transfer coefficients for terrestrial foodchain: their derivation and limitations

    International Nuclear Information System (INIS)

    Ng, Y.C.; Colsher, C.S.; Thompson, S.E.

    1979-01-01

    Transfer coefficients to predict the passage of isotopes from the environment to terrestrial foods have been derived for various radionuclides of importance in the nuclear fuel cycle. These data update and extend previously recommended handbook values. We derive transfer coefficients to terrestrial foods and describe the systematics of the derived transfer coefficients. Suggestions are offered for changes in the values of transfer coefficients to terrestrial foods that now appear in federal regulatory guides. Deficiencies in our present knowledge concerning transfer coefficients and limitations in the use of these values to ensure compliance with radiation protection standards are discussed

  17. CEC natural analogue working group

    International Nuclear Information System (INIS)

    Come, B.; Chapman, N.A.

    1986-01-01

    The second meeting of the CEC Natural Analogue Working Group took place on June 17-19, 1986, hosted by the Swiss NAGRA in Interlaken (CH). A review of recent progress in natural analogue programmes was carried out, and complemented by detailed discussions about geomicrobiology, archaeological analogues, natural colloids, and use of analogues to increase confidence in safety assessments for radioactive waste disposal. A statement drafted by the Group, and the presentations made, are put together in this report

  18. Genomics-informed isolation and characterization of a symbiotic Nanoarchaeota system from a terrestrial geothermal environment.

    Science.gov (United States)

    Wurch, Louie; Giannone, Richard J; Belisle, Bernard S; Swift, Carolyn; Utturkar, Sagar; Hettich, Robert L; Reysenbach, Anna-Louise; Podar, Mircea

    2016-07-05

    Biological features can be inferred, based on genomic data, for many microbial lineages that remain uncultured. However, cultivation is important for characterizing an organism's physiology and testing its genome-encoded potential. Here we use single-cell genomics to infer cultivation conditions for the isolation of an ectosymbiotic Nanoarchaeota ('Nanopusillus acidilobi') and its host (Acidilobus, a crenarchaeote) from a terrestrial geothermal environment. The cells of 'Nanopusillus' are among the smallest known cellular organisms (100-300 nm). They appear to have a complete genetic information processing machinery, but lack almost all primary biosynthetic functions as well as respiration and ATP synthesis. Genomic and proteomic comparison with its distant relative, the marine Nanoarchaeum equitans illustrate an ancient, common evolutionary history of adaptation of the Nanoarchaeota to ectosymbiosis, so far unique among the Archaea.

  19. Sensitvie life detection strategies for low-biomass environments: optimizing extraction of nucleic acids adsorbing to terrestrial and Mars analogue minerals.

    NARCIS (Netherlands)

    Direito, S.O.L.; Marees, A.; Roling, W.F.M.

    2012-01-01

    The adsorption of nucleic acids to mineral matrixes can result in low extraction yields and negatively influences molecular microbial ecology studies, in particular for low-biomass environments on Earth and Mars. We determined the recovery of nucleic acids from a range of minerals relevant to Earth

  20. Field Exploration and Life Detection Sampling for Planetary Analogue Research (FELDSPAR): Variability and Correlation in Biomarker and Mineralogy Measurements from Icelandic Mars Analogues

    Science.gov (United States)

    Gentry, D.; Amador, E.; Cable, M. L.; Cantrell, T.; Chaudry, N.; Cullen, T.; Duca, Z.; Jacobsen, M.; Kirby, J.; McCaig, H.; hide

    2018-01-01

    In situ exploration of planetary environments allows biochemical analysis of sub-centimeter-scale samples; however, landing sites are selected a priori based on measurable meter- to kilometer-scale geological features. Optimizing life detection mission science return requires both understanding the expected biomarker distributions across sample sites at different scales and efficiently using first-stage in situ geochemical instruments to justify later-stage biological or chemical analysis. Icelandic volcanic regions have an extensive history as Mars analogue sites due to desiccation, low nutrient availability, and temperature extremes, in addition to the advantages of geological youth and isolation from anthropogenic contamination. Many Icelandic analogue sites are also rugged and remote enough to create the same type of instrumentation and sampling constraints typically faced by robotic exploration.

  1. CEC Natural Analogue Working Group

    International Nuclear Information System (INIS)

    Come, B.; Chapman, N.A.

    1989-01-01

    The central theme for the third meeting of the CEC analogue working group was ''How can analogue data be used for performance assessments, both in support of the results and for presentation to the public''. This report puts together the most recent achievements in this field, together with a review of on-going natural analogue programmes

  2. The weak force and SETH: The search for Extra-Terrestrial Homochirality

    Science.gov (United States)

    MacDermott, Alexandra J.

    1996-07-01

    We propose that a search for extra-terrestrial life can be approached as a Search for Extra-Terrestrial Homochirality-SETH. Homochirality is probably a pre-condition for life, so a chiral influence may be required to get life started. We explain how the weak force mediated by the Z0 boson gives rise to a small parity-violating energy difference (PVED) between enantiomers, and discuss how the resulting small excess of the more stable enantiomer may be amplified to homochirality. Titan and comets are good places to test for emerging pre-biotic homochirality, while on Mars there may be traces of homochirality as a relic of extinct life. Our calculations of the PVED show that the natural L-amino acids are indeed more stable than their enantiomers, as are several key D-sugars and right-hand helical DNA. Thiosubstituted DNA analogues show particularly large PVEDs. L-quartz is also more stable than D-quartz, and we believe that further crystal counts should be carried out to establish whether reported excesses of L quartz are real. Finding extra-terrestrial molecules of the same hand as on Earth would lend support to the universal chiral influence of the weak force. We describe a novel miniaturized space polarimeter, called the SETH Cigar, which we hope to use to detect optical rotation on other planets. Moving parts are avoided by replacing the normal rotating polarizer by multiple fixed polarizers at different angles as in the eye of the bee. Even if we do not find the same hand as on Earth, finding extra-terrestrial optical rotation would be of enormous importance as it would still be the homochiral signature of life.

  3. Transformation and bioavailability of metal oxide nanoparticles in aquatic and terrestrial environments. A review.

    Science.gov (United States)

    Amde, Meseret; Liu, Jing-Fu; Tan, Zhi-Qiang; Bekana, Deribachew

    2017-11-01

    Metal oxide nanoparticles (MeO-NPs) are among the most consumed NPs and also have wide applications in various areas which increased their release into the environmental system. Aquatic (water and sediments) and terrestrial compartments are predicted to be the destination of the released MeO-NPs. In these compartments, the particles are subjected to various dynamic processes such as physical, chemical and biological processes, and undergo transformations which drive them away from their pristine state. These transformation pathways can have strong implications for the fate, transport, persistence, bioavailability and toxic-effects of the NPs. In this critical review, we provide the state-of-the-knowledge on the transformation processes and bioavailability of MeO-NPs in the environment, which is the topic of interest to researchers. We also recommend future research directions in the area which will support future risk assessments by enhancing our knowledge of the transformation and bioavailability of MeO-NPs. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Thermal environment and sleep in winter shelter-analogue settings

    Science.gov (United States)

    Mochizuki, Yosuke; Maeda, Kazuki; Nabeshima, Yuki; Tsuzuki, Kazuyo

    2017-10-01

    We aimed to examine sleep in shelter-analogue settings in winter to determine the sleep and environmental conditions in evacuation shelters. Twelve young healthy students took part in the sleep study of two nights for seven hours from 0 AM to 7 AM in a gymnasium. One night the subject used a pair of futons and on the other the subject used emergency supplies consisting of four blankets and a set of portable partitions. Air temperature, humidity were measured around the sleeping subjects through the night. Sleep parameters, skin temperature, microclimate temperature, rectal temperature, and heart rate of the subjects were continuously measured and recorded during the sleeping period. The subjects completed questionnaires relating to thermal comfort and subjective sleep before and after sleep. The sleep efficiency indices were lower when the subjects slept using the blankets. As the microclimate temperature between the human body and blanket was lower, mean skin temperature was significantly lower in the case of blankets.

  5. Climate change impacts on the disposal environment: a climate analogue approach - 59274

    International Nuclear Information System (INIS)

    Leterme, Bertrand; Mallants, Dirk

    2012-01-01

    Document available in abstract form only. Full text of publication follows: The Belgian Agency for Radioactive Waste and Enriched Fissile Materials (ONDRAF/NIRAS) aims to develop a surface disposal facility for L/ILW in Dessel (North-East of Belgium). The objective of this study is to provide estimates for the next few millennia of both infiltration through the planned earth cover and groundwater recharge in the vicinity of the Dessel site. Available predictions of future temperature and precipitation often extend until AD 2100 only (e.g. IPCC). To circumvent this data limitation, we use existing records of climatic analogue stations deemed representative of future climates in Belgium. The following climate states are considered: DO (maritime temperate, present-day climate in Dessel), Cs/Cr (subtropical with dry summers/no rainfall seasonality), EO (cold without permafrost) and FT (cold with permafrost). Climate data is then used in 1-D modelling of the soil-plant-atmosphere system to quantify infiltration through the earth cover and recharge to groundwater for a sequence of probable future climate states. Using criteria including altitude, distance to moisture source, and atmospheric circulation system, several analogue stations were selected for each climate state Cs/Cr and EO/FT. They provided time series (30 years) of meteorological observations that allowed calculating potential evapotranspiration and water balance components for soils overlying the repository

  6. Bentonite analogue research related to geological disposal of radioactive waste: current status and future outlook

    International Nuclear Information System (INIS)

    Reijonen, H.M.; Russel, A.W.

    2015-01-01

    The practice of utilising natural analogues in assessing the long-term behaviour of various components of geological repositories for radioactive waste is already well established in most disposal programmes. Numerous studies on bentonites, focussing on bentonite interaction with other components of the engineered barrier system and a range of host rock environments, are present in the literature. In this article, recent bentonite natural analogue studies are briefly reviewed, and gaps in the current literature identified, with the aim of (1) suggesting where relevant new information could be obtained by data mining published bentonite natural analogue studies with a new focus on current safety case requirements, (2) collecting relevant information by revisiting known bentonite analogue sites and conducting investigations with more appropriate analytical techniques, and (3) identifying novel study sites where, for example, bentonite longevity in very dilute to highly saline groundwater conditions can be studied. It must be noted that the use of natural analogues in safety case development is likely to be site and repository design-specific in nature and thus emphasis is placed on the appropriate use of relevant natural analogue data on bentonite longevity. (authors)

  7. Bentonite analogue research related to geological disposal of radioactive waste: current status and future outlook

    Energy Technology Data Exchange (ETDEWEB)

    Reijonen, H.M. [Saanio and Rickkola Oy, Helsinki (Finland); Russel, A.W. [Bedrock Geosciences, Auenstein (Switzerland)

    2015-06-15

    The practice of utilising natural analogues in assessing the long-term behaviour of various components of geological repositories for radioactive waste is already well established in most disposal programmes. Numerous studies on bentonites, focussing on bentonite interaction with other components of the engineered barrier system and a range of host rock environments, are present in the literature. In this article, recent bentonite natural analogue studies are briefly reviewed, and gaps in the current literature identified, with the aim of (1) suggesting where relevant new information could be obtained by data mining published bentonite natural analogue studies with a new focus on current safety case requirements, (2) collecting relevant information by revisiting known bentonite analogue sites and conducting investigations with more appropriate analytical techniques, and (3) identifying novel study sites where, for example, bentonite longevity in very dilute to highly saline groundwater conditions can be studied. It must be noted that the use of natural analogues in safety case development is likely to be site and repository design-specific in nature and thus emphasis is placed on the appropriate use of relevant natural analogue data on bentonite longevity. (authors)

  8. Analogue alternative the electronic analogue computer in Britain and the USA, 1930-1975

    CERN Document Server

    Small, James S

    2013-01-01

    We are in the midst of a digital revolution - until recently, the majority of appliances used in everyday life have been developed with analogue technology. Now, either at home or out and about, we are surrounded by digital technology such as digital 'film', audio systems, computers and telephones. From the late 1940s until the 1970s, analogue technology was a genuine alternative to digital, and the two competing technologies ran parallel with each other. During this period, a community of engineers, scientists, academics and businessmen continued to develop and promote the analogue computer.

  9. Pressurized brines in continental Antarctica as a possible analogue of Mars.

    Science.gov (United States)

    Forte, Emanuele; Dalle Fratte, Michele; Azzaro, Maurizio; Guglielmin, Mauro

    2016-09-12

    Interest in brines in extreme and cold environments has recently increased after they have been found on Mars. Those brines can be potential new subsurface habitats for peculiar ecosystems. In the McMurdo Dry Valleys of the Antarctic, the best analogue for Mars conditions, only a few cases of brines have been identified in some perennially frozen lakes and in one case in an underground aquifer. Here, we present the occurrence of pressurized brines in a shallow perennially ice-covered lake south of 70°S in an ice-free area of Victoria Land, Antarctica. For the first time, we also imaged, by means of ground penetrating radar data, the existence of a pingo-like-feature (PLF) formed by the extrusion of brines, which has also been confirmed by borehole evidence. Those brines are fed by an underground talik external to the lake basin, enhancing the possibility of unexploited ecosystems that could find an analogue in Martian environments.

  10. Novel peptide chemistry in terrestrial animals: natural luciferin analogues from the bioluminescent earthworm Fridericia heliota.

    Science.gov (United States)

    Dubinnyi, Maxim A; Tsarkova, Aleksandra S; Petushkov, Valentin N; Kaskova, Zinaida M; Rodionova, Natalja S; Kovalchuk, Sergey I; Ziganshin, Rustam H; Baranov, Mikhail S; Mineev, Konstantin S; Yampolsky, Ilia V

    2015-03-02

    We report isolation and structure elucidation of AsLn5, AsLn7, AsLn11 and AsLn12: novel luciferin analogs from the bioluminescent earthworm Fridericia heliota. They were found to be highly unusual modified peptides, comprising either of the two tyrosine-derived chromophores, CompX or CompY and a set of amino acids, including threonine, gamma-aminobutyric acid, homoarginine, and unsymmetrical N,N-dimethylarginine. These natural compounds represent a unique peptide chemistry found in terrestrial animals and rise novel questions concerning their biosynthetic origin. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Amphibian populations in the terrestrial environment: Is there evidence of declines of terrestrial forest amphibians in northwestern California?

    Science.gov (United States)

    Hartwell H. Welsh Jr.; Gary M. Fellers; Amy J. Lind

    2007-01-01

    Amphibian declines have been documented worldwide; however the vast majority are species associated with aquatic habitats. Information on the status and trends of terrestrial amphibians is almost entirely lacking. Here we use data collected across a 12-yr period (sampling from 1984–86 and from 1993–95) to address the question of whether evidence exists for declines...

  12. The distribution of tritium in the terrestrial and aquatic environments of the Creys-Malville nuclear power plant (2002-2005)

    International Nuclear Information System (INIS)

    Jean-Baptiste, P.; Baumier, D.; Fourre, E.; Dapoigny, A.; Clavel, B.

    2007-01-01

    The Creys-Malville nuclear plant, located on the left bank of the Rhone, was shut down in 1998. The facilities are currently in their initial stage of dismantling. In order to establish a baseline for tritium in the vicinity of the site prior to the main dismantling phase, we carried out a monitoring program between 2002 and 2005 in the main terrestrial and aquatic compartments of the local environment. Tritium levels in the groundwaters and in the Rhone waters correspond to the regional tritium concentration in precipitation. The data obtained for the terrestrial environment are also in good agreement with the regional background and do not show any specific signature linked to the nuclear plant. The various aquatic compartments of the Rhone (fish, plant, sediment) are significantly enriched in tritium both upstream and downstream of the power plant: although Tissue-Free Water Tritium concentrations are in equilibrium with the river water, the non-exchangeable fraction of organic bound tritium in plants and fishes shows values which outpace the river water background by one to two orders of magnitude, and up to four to five orders of magnitude in the sediments. This tritium anomaly is not related to the nuclear plant, as it is already present at the Swiss border 100 km upstream of the site. Although fine particles of tritiated polystyrene entering the composition of the luminous paints used by the clock industry have been suspected on several occasions, the exact nature and the origin of this tritium source remain unknown and require further investigations

  13. Modelling the dynamics of ambient dose rates induced by radiocaesium in the Fukushima terrestrial environment

    Science.gov (United States)

    Gonze, Marc-André; Mourlon, Christophe; Calmon, Philippe; Manach, Erwan; Debayle, Christophe; Baccou, Jean

    2017-09-01

    Since the Fukushima accident, Japanese scientists have been intensively monitoring ambient radiations in the highly contaminated territories situated within 80 km of the nuclear site. The surveys that were conducted through mainly carborne, airborne and in situ gamma-ray measurement devices, enabled to efficiently characterize the spatial distribution and temporal evolution of air dose rates induced by Caesium-134 and Caesium-137 in the terrestrial systems. These measurements revealed that radiation levels decreased at rates greater than expected from physical decay in 2011-2012 (up to a factor of 2), and dependent on the type of environment (i.e. urban, agricultural or forest). Unlike carborne measurements that may have been strongly influenced by the depuration of road surfaces, no obvious reason can be invoked for airborne measurements, especially above forests that are known to efficiently retain and recycle radiocaesium. The purpose of our research project is to develop a comprehensive understanding of the data acquired by Japanese, and identify the environmental mechanisms or factors that may explain such decays. The methodology relies on the use of a process-based and spatially-distributed dynamic model that predicts radiocaesium transfer and associated air dose rates inside/above a terrestrial environment (e.g., forests, croplands, meadows, bare soils and urban areas). Despite the lack of site-specific data, our numerical study predicts decrease rates that are globally consistent with both aerial and in situ observations. The simulation at a flying altitude of 200 m indicated that ambient radiation levels decreased over the first 12 months by about 45% over dense urban areas, 15% above evergreen coniferous forests and between 2 and 12% above agricultural lands, owing to environmental processes that are identified and discussed. In particular, we demonstrate that the decrease over evergreen coniferous regions might be due the combined effects of canopy

  14. UK Natural Analogue Co-Ordinating Group: first annual progress report

    International Nuclear Information System (INIS)

    Hooker, P.J.; Chapman, N.A.

    1987-11-01

    The British Geological Survey is reponsible for co-ordinating the Department of the Environment's programme of natural analogue studies of radionuclide migration, a research programme that involved both UK and overseas sites. Co-ordination is achieved through the UK Natural Analogue Co-ordinating Group (NACG) which was established in October 1986. It has met three times to date and its function is to ensure that the different research projects have an integrated purpose aimed at improving and applying our understanding of natural geochemical processes in a way that will increase our confidence in long-term modelling predictions. Improved modelling prediction of radionuclide transport in the geosphere will directly benefit the performance and safety assessments of proposed radioactive waste repositories. (author)

  15. Natural Analogue Synthesis Report

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Simmons

    2002-05-01

    The purpose of this report is to present analogue studies and literature reviews designed to provide qualitative and quantitative information to test and provide added confidence in process models abstracted for performance assessment (PA) and model predictions pertinent to PA. This report provides updates to studies presented in the ''Yucca Mountain Site Description'' (CRWMS M and O 2000 [151945], Section 13) and new examples gleaned from the literature, along with results of quantitative studies conducted specifically for the Yucca Mountain Site Characterization Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate additional understanding of processes expected to occur during postclosure at a potential Yucca Mountain repository. The report focuses on key processes by providing observations and analyses of natural and anthropogenic (human-induced) systems to improve understanding and confidence in the operation of these processes under conditions similar to those that could occur in a nuclear waste repository. The process models include those that represent both engineered and natural barrier processes. A second purpose of this report is to document the various applications of natural analogues to geologic repository programs, focusing primarily on the way analogues have been used by the YMP. This report is limited to providing support for PA in a confirmatory manner and to providing corroborative inputs for process modeling activities. Section 1.7 discusses additional limitations of this report. Key topics for this report are analogues to emplacement drift degradation, waste form degradation, waste package degradation, degradation of other materials proposed for the engineered barrier, seepage into drifts, radionuclide flow and transport in the unsaturated zone (UZ), analogues to coupled thermal-hydrologic-mechanical-chemical processes, saturated zone (SZ) transport

  16. NATURAL ANALOGUE SYNTHESIS REPORT

    International Nuclear Information System (INIS)

    Simmons, A.M.

    2004-01-01

    The purpose of this report is to present analogue studies and literature reviews designed to provide qualitative and quantitative information to test and provide added confidence in process models abstracted for performance assessment (PA) and model predictions pertinent to PA. This report provides updates to studies presented in the Yucca Mountain Site Description (CRWMS M and O 2000 [151945], Section 13) and new examples gleaned from the literature along with results of quantitative studies conducted specifically for the Yucca Mountain Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate additional understanding of processes expected to occur during postclosure at a potential Yucca Mountain repository. The report focuses on key processes by providing observations and analyses of natural and anthropogenic (human-induced) systems to improve understanding and confidence in the operation of these processes under conditions similar to those that could occur in a nuclear waste repository. The process models include those that represent both engineered and natural barrier processes. A second purpose of this report is to document the various applications of natural analogues to geologic repository programs, focusing primarily on the way analogues have been used by the YMP. This report is limited to providing support for PA in a confirmatory manner and to providing corroborative inputs for process modeling activities. Section 1.7 discusses additional limitations of this report. Key topics for this report are analogues to emplacement-drift degradation, waste-form degradation, waste-package degradation, degradation of other materials proposed for the engineered barrier, seepage into drifts, radionuclide flow and transport in the unsaturated zone (UZ), analogues to coupled thermal-hydrologic-mechanical-chemical processes, saturated-zone (SZ) transport, impact of radionuclide release on the biosphere

  17. Natural analogue study on engineered barriers for underground disposal of radioactive wastes

    International Nuclear Information System (INIS)

    Araki, K.; Motegi, M.; Emoto, Y.; Kaji, Y.; Ikari, S.; Nada, T.; Watanabe, T.

    1989-01-01

    This is a report to develop the natural analogue methodology for the assessment of the life of the engineered barriers beyond the time period of normal experiments, 1000 years, for the disposal of low-level radioactive wastes with activity levels greater than those of wastes acceptable for shallow land burial in Japan. Geological and archeological events and objects available for the assessment of the possible life of each engineered barrier are surveyed. Taking heavy precipitation into account in Japan, a long-term, zero-release engineered barrier system using long-term durable materials based on the natural analogue events and objects is proposed along with the conventional type of water permeable engineered barrier system. The combination of the material quality and the environment that could be achieved within the repository is important for the long-term durability of the engineered barrier material. It is proposed that for the natural analogue study a physico-chemical methodology, which may be referred to as the physico-chemical natural history, is necessary to get parameters from the natural analogue events for the long-term assessment of the disposal system

  18. A dual use case study of space technologies for terrestrial medical applications (Conference Presentation)

    Science.gov (United States)

    Cozmuta, Ioana

    2017-05-01

    Many challenges exist in understanding the human body as a whole, its adaptability, its resilience, its immunological response, its healing and regeneration power. New knowledge is usually obtained by exploring unique conditions and environments and space is one such variable. Primarily, these attributes have been studied in space for the purpose of understanding the effect of the space environment on long duration space travel. However a myriad of lessons learned have emerged that are important for terrestrial medicine problems such as cardiovascular changes, intracranial pressure changes, vision changes, reduced immunity, etc. For medical study purposes, the changes induced by the space environment on the human body are in general fast and predictable; they persist while in the space environment but also revert to the initial pre-flight healthy state upon return to Earth. This provides a unique cycle to study wellness and disease prediction as well as to develop more effective countermeasures for the benefit of people on earth. At a scientific level, the environment of space can be used to develop new lines of investigations and new knowledge to push the terrestrial state of the art (i.e. study of phase diagrams, identification of new system's states, etc). Moreover, the specialized requirements for space medicine have driven advances in terrestrial medical technologies in areas such as monitoring, diagnostic, prevention and treatment. This talk will provide an overview of compelling examples in key areas of interest for terrestrial medical applications.

  19. The weak force and SETH: The search for Extra-Terrestrial Homochirality

    International Nuclear Information System (INIS)

    MacDermott, A.J.

    1996-01-01

    We propose that a search for extra-terrestrial life can be approached as a Search for Extra-Terrestrial Homochirality emdash SETH. Homochirality is probably a pre-condition for life, so a chiral influence may be required to get life started. We explain how the weak force mediated by the Z 0 boson gives rise to a small parity-violating energy difference (PVED) between enantiomers, and discuss how the resulting small excess of the more stable enantiomer may be amplified to homochirality. Titan and comets are good places to test for emerging pre-biotic homochirality, while on Mars there may be traces of homochirality as a relic of extinct life. Our calculations of the PVED show that the natural L-amino acids are indeed more stable than their enantiomers, as are several key D-sugars and right-hand helical DNA. Thiosubstituted DNA analogues show particularly large PVEDs. L-quartz is also more stable than D-quartz, and we believe that further crystal counts should be carried out to establish whether reported excesses of L quartz are real. Finding extra-terrestrial molecules of the same hand as on Earth would lend support to the universal chiral influence of the weak force. We describe a novel miniaturized space polarimeter, called the SETH Cigar, which we hope to use to detect optical rotation on other planets. Moving parts are avoided by replacing the normal rotating polarizer by multiple fixed polarizers at different angles as in the eye of the bee. Even if we do not find the same hand as on Earth, finding extra-terrestrial optical rotation would be of enormous importance as it would still be the homochiral signature of life. copyright 1996 American Institute of Physics

  20. Environmental and radiological safety studies. Interaction of 238PuO2 heat sources with terrestrial and aquatic environments. Progress report, July 1-September 30, 1980

    International Nuclear Information System (INIS)

    Waterbury, G.R.

    1981-01-01

    The containers for 238 PuO 2 heat sources in radioisotope thermoelectric generators are designed with large safety factors to ensure that they will withstand reentry from orbit and impact with the earth and safely contain the nuclear fuel until it is recovered. Existing designs have proved more than adequately safe, but the Space and Terrestrial Division of the Department of Energy Office of Advanced Nuclear Systems and Projects continually seeks more information about the heat sources to improve their safety. The work discussed here includes studies of the effects on the heat source of terrestrial and aquatic environments to obtain data for design of even safer systems. The data obtained in several ongoing experiments are presented; these data tables will be updated quarterly. Discussions of experimental details are minimized and largely repetitive in succeeding reports. Compilations of usable data generated in each experiment are emphasized. These compilations include data from environmental chamber experiments that simulate terrestrial conditions, experiments to measure PuO 2 dissolution rates, soil column experiments to measure sorption of plutonium by soils, and several aquatic experiments

  1. Super-long Anabiosis of Ancient Microorganisms in Ice and Terrestrial Models for Development of Methods to Search for Life on Mars, Europa and other Planetary Bodies

    Science.gov (United States)

    Abyzov, S. S.; Duxbury, N. S.; Bobin, N. E.; Fukuchi, M.; Hoover, R. B.; Kanda, H.; Mitskevich, I. N.; Mulyukin, A. L.; Naganuma, T.; Poglazova, M. N.; hide

    2007-01-01

    Successful missions to Mars, Europe and other bodies of the Solar system have created a prerequisite to search for extraterrestrial life. The first attempts of microbial life detection on the Martian surface by the Viking landed missions gave no biological results. Microbiological investigations of the Martian subsurface ground ice layers seem to be more promising. It is well substantiated to consider the Antarctic ice sheet and the Antarctic and Arctic permafrost as terrestrial analogues of Martian habitats. The results of our long-standing microbiological studies of the Antarctic ice would provide the basis for detection of viable microbial cells on Mars. Our microbiological investigations of the deepest and thus most ancient strata of the Antarctic ice sheet for the first time gave evidence for the natural phenomenon of long-term anabiosis (preservation of viability and vitality for millennia years). A combination of classical microbiological methods, epifluorescence microscopy, SEM, TEM, molecular diagnostics, radioisotope labeling and other techniques made it possible for us to obtain convincing proof of the presence of pro- and eukaryotes in the Antarctic ice sheet. In this communication, we will review and discuss some critical issues related to the detection of viable microorganisms in cold terrestrial environments with regard to future searches for microbial life and/or its biological signatures on extraterrestrial objects.

  2. The radiological situation at the atolls of Mururoa and Fangataufa. Technical report. V. 1. Radionuclide concentrations measured in the terrestrial environment of the atolls

    International Nuclear Information System (INIS)

    1998-08-01

    This report provides technical details of the terrestrial sampling and measurement campaign undertaken as part of the Study of the Radiological Situation at the Atolls of Mururoa, Fangataufa by the Terrestrial Working Group. The primary objective of this group was to evaluate existing French data on the presence of environmental radionuclides on the atolls of Mururoa, Fangataufa and Tureia in French Polynesia. All aspects of the terrestrial environments of Mururoa and Fangataufa Atolls - the sites of atmospheric and underground nuclear tests - were included in the sampling programme. Tureia Atoll - the nearest inhabited island - was also included in the sampling programme, in order to determine whether deposits from atmospheric testing are detectable there. The task required the co-operation of many different parties in order to provide the supporting logistics for the sampling campaign and the expertise for analysing the different radionuclides of interest in the samples collected. Samples were analysed by members of the IAEA's co-ordinated international network of Analytical Laboratories for Measuring Environmental Radioactivity (ALMERA) and the Agency's laboratories, Seibersdorf. Samples were also sent to the French Service Mixte de Surveillance Radiologique et Biologique (SMSRB)

  3. Transformation and bioavailability of metal oxide nanoparticles in aquatic and terrestrial environments. A review

    International Nuclear Information System (INIS)

    Amde, Meseret; Liu, Jing-fu; Tan, Zhi-Qiang; Bekana, Deribachew

    2017-01-01

    Metal oxide nanoparticles (MeO-NPs) are among the most consumed NPs and also have wide applications in various areas which increased their release into the environmental system. Aquatic (water and sediments) and terrestrial compartments are predicted to be the destination of the released MeO-NPs. In these compartments, the particles are subjected to various dynamic processes such as physical, chemical and biological processes, and undergo transformations which drive them away from their pristine state. These transformation pathways can have strong implications for the fate, transport, persistence, bioavailability and toxic-effects of the NPs. In this critical review, we provide the state-of-the-knowledge on the transformation processes and bioavailability of MeO-NPs in the environment, which is the topic of interest to researchers. We also recommend future research directions in the area which will support future risk assessments by enhancing our knowledge of the transformation and bioavailability of MeO-NPs. - Highlights: • Current state-of-the-knowledge on the transformation and bioavailability of MeO-NPs in the environment has been provided. • Effects of MeO-NPs behavior on their transformations have been reviewed. • Role of the transformation processes on bioavailability of the NPs have been discussed. • Future research directions required to fill the existing research gaps have been provided. - Transformations of MeO-NPs depend on nature of the NPs themselves and chemistry of the medium, and can significantly affect their fate, bioavailability and toxic-effects.

  4. Trophic Transfer of Arsenic from an Aquatic Insect to Terrestrial Insect Predators.

    Science.gov (United States)

    Mogren, Christina L; Walton, William E; Parker, David R; Trumble, John T

    2013-01-01

    The movement of energy and nutrients from aquatic to terrestrial ecosystems can be substantial, and emergent aquatic insects can serve as biovectors not only for nutrients, but also for contaminants present in the aquatic environment. The terrestrial predators Tenodera aridifolia sinensis (Mantodea: Mantidae) and Tidarren haemorrhoidale (Araneae: Theridiidae) and the aquatic predator Buenoa scimitra (Hemiptera: Notonectidae) were chosen to evaluate the efficacy of arsenic transfer between aquatic and terrestrial environments. Culex tarsalis larvae were reared in either control water or water containing 1000 µg l(-1) arsenic. Adults that emerged from the control and arsenic treatments were fed to the terrestrial predators, and fourth instar larvae were fed to the aquatic predator reared in control or arsenic contaminated water. Tenodera a. sinensis fed arsenic-treated Cx. tarsalis accumulated 658±130 ng g(-1) of arsenic. There was no significant difference between control and arsenic-fed T. haemorrhoidale (range 142-290 ng g(-1)). Buenoa scimitra accumulated 5120±406 ng g(-1) of arsenic when exposed to arsenic-fed Cx. tarsalis and reared in water containing 1000 µg l(-1) arsenic. There was no significant difference between controls or arsenic-fed B. scimitra that were not exposed to water-borne arsenic, indicating that for this species environmental exposure was more important in accumulation than strictly dietary arsenic. These results indicate that transfer to terrestrial predators may play an important role in arsenic cycling, which would be particularly true during periods of mass emergence of potential insect biovectors. Trophic transfer within the aquatic environment may still occur with secondary predation, or in predators with different feeding strategies.

  5. Trophic Transfer of Arsenic from an Aquatic Insect to Terrestrial Insect Predators

    Science.gov (United States)

    Mogren, Christina L.; Walton, William E.; Parker, David R.; Trumble, John T.

    2013-01-01

    The movement of energy and nutrients from aquatic to terrestrial ecosystems can be substantial, and emergent aquatic insects can serve as biovectors not only for nutrients, but also for contaminants present in the aquatic environment. The terrestrial predators Tenodera aridifolia sinensis (Mantodea: Mantidae) and Tidarren haemorrhoidale (Araneae: Theridiidae) and the aquatic predator Buenoa scimitra (Hemiptera: Notonectidae) were chosen to evaluate the efficacy of arsenic transfer between aquatic and terrestrial environments. Culex tarsalis larvae were reared in either control water or water containing 1000 µg l−1 arsenic. Adults that emerged from the control and arsenic treatments were fed to the terrestrial predators, and fourth instar larvae were fed to the aquatic predator reared in control or arsenic contaminated water. Tenodera a. sinensis fed arsenic-treated Cx. tarsalis accumulated 658±130 ng g−1 of arsenic. There was no significant difference between control and arsenic-fed T. haemorrhoidale (range 142–290 ng g−1). Buenoa scimitra accumulated 5120±406 ng g−1 of arsenic when exposed to arsenic-fed Cx. tarsalis and reared in water containing 1000 µg l−1 arsenic. There was no significant difference between controls or arsenic-fed B. scimitra that were not exposed to water-borne arsenic, indicating that for this species environmental exposure was more important in accumulation than strictly dietary arsenic. These results indicate that transfer to terrestrial predators may play an important role in arsenic cycling, which would be particularly true during periods of mass emergence of potential insect biovectors. Trophic transfer within the aquatic environment may still occur with secondary predation, or in predators with different feeding strategies. PMID:23826344

  6. Trophic Transfer of Arsenic from an Aquatic Insect to Terrestrial Insect Predators.

    Directory of Open Access Journals (Sweden)

    Christina L Mogren

    Full Text Available The movement of energy and nutrients from aquatic to terrestrial ecosystems can be substantial, and emergent aquatic insects can serve as biovectors not only for nutrients, but also for contaminants present in the aquatic environment. The terrestrial predators Tenodera aridifolia sinensis (Mantodea: Mantidae and Tidarren haemorrhoidale (Araneae: Theridiidae and the aquatic predator Buenoa scimitra (Hemiptera: Notonectidae were chosen to evaluate the efficacy of arsenic transfer between aquatic and terrestrial environments. Culex tarsalis larvae were reared in either control water or water containing 1000 µg l(-1 arsenic. Adults that emerged from the control and arsenic treatments were fed to the terrestrial predators, and fourth instar larvae were fed to the aquatic predator reared in control or arsenic contaminated water. Tenodera a. sinensis fed arsenic-treated Cx. tarsalis accumulated 658±130 ng g(-1 of arsenic. There was no significant difference between control and arsenic-fed T. haemorrhoidale (range 142-290 ng g(-1. Buenoa scimitra accumulated 5120±406 ng g(-1 of arsenic when exposed to arsenic-fed Cx. tarsalis and reared in water containing 1000 µg l(-1 arsenic. There was no significant difference between controls or arsenic-fed B. scimitra that were not exposed to water-borne arsenic, indicating that for this species environmental exposure was more important in accumulation than strictly dietary arsenic. These results indicate that transfer to terrestrial predators may play an important role in arsenic cycling, which would be particularly true during periods of mass emergence of potential insect biovectors. Trophic transfer within the aquatic environment may still occur with secondary predation, or in predators with different feeding strategies.

  7. Guidelines to Avoid Biocontamination of Antarctic Subglacial Aquatic Environments: Forward Contamination Concerns, Environmental Management and Scientific Stewardship of Icy analogue environments

    Science.gov (United States)

    Race, M. S.; Hobbie, J.; et al.

    2007-12-01

    For more than a decade, scientists and space mission planners have recognized the importance of collaborative information exchange with the Antarctic research community to address their many shared exploration challenges, from drilling methods, remote sample collection, and data interpretation, to concerns about cross contamination that could adversely impact both the environment and interpretation of scientific data. Another shared concern exists in the regulatory realm; both the Antarctic and outer space environments are subject to separate international treaties that impose regulatory controls and oversight with serious implications for exploration planning. In recent years, both communities have faced the need to adjust their regulatory controls in light of fast-paced advances in scientific understanding of extreme environments, particularly related to potential microbial life. Both communities have sought and received advice from the National Research Council (NRC) through studies that suggested ways to update their respective oversight and regulatory systems while allowing for continued scientific exploration. A recently completed NRC study "Exploration of Antarctic Subglacial Aquatic Environments: Environmental and Scientific Stewardship" provided a suite of recommendations to address1) 'cleanliness' levels necessary for equipment and devices used in exploration of subglacial aquatic environments, as well as 2) the scientific basis for contamination standards, and 3) the steps for defining an overall exploration strategy conducive to sound environmental management and scientific stewardship. This talk will present the findings of the recent multinational NRC study, which is likely to translate into useful information for analogue studies that proceed to test techniques and capabilities for exploring an Europan ocean, other icy celestial locations, and related science targets on Earth. As the science and exploration of subglacial environments grows beyond its

  8. A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments

    Science.gov (United States)

    Lumaret, Jean-Pierre; Errouissi, Faiek; Floate, Kevin; Römbke, Jörg; Wardhaugh, Keith

    2012-01-01

    The avermectins, milbemycins and spinosyns are collectively referred to as macrocyclic lactones (MLs) which comprise several classes of chemicals derived from cultures of soil micro-organisms. These compounds are extensively and increasingly used in veterinary medicine and agriculture. Due to their potential effects on non-target organisms, large amounts of information on their impact in the environment has been compiled in recent years, mainly caused by legal requirements related to their marketing authorization or registration. The main objective of this paper is to critically review the present knowledge about the acute and chronic ecotoxicological effects of MLs on organisms, mainly invertebrates, in the terrestrial and aquatic environment. Detailed information is presented on the mode-of-action as well as the ecotoxicity of the most important compounds representing the three groups of MLs. This information, based on more than 360 references, is mainly provided in nine tables, presenting the effects of abamectin, ivermectin, eprinomectin, doramectin, emamectin, moxidectin, and spinosad on individual species of terrestrial and aquatic invertebrates as well as plants and algae. Since dung dwelling organisms are particularly important non-targets, as they are exposed via dung from treated animals over their whole life-cycle, the information on the effects of MLs on dung communities is compiled in an additional table. The results of this review clearly demonstrate that regarding environmental impacts many macrocyclic lactones are substances of high concern particularly with larval instars of invertebrates. Recent studies have also shown that susceptibility varies with life cycle stage and impacts can be mitigated by using MLs when these stages are not present. However information on the environmental impact of the MLs is scattered across a wide range of specialised scientific journals with research focusing mainly on ivermectin and to a lesser extent on abamectin

  9. Terrestrial ecosystems in a changing world

    Energy Technology Data Exchange (ETDEWEB)

    Canadell, J.G. [CSIRO Marine and Atmospheric Research, Canberra, ACT (Australia). Global Carbon Project; Pataki, D.E. [California Univ., Irvine, CA (United States). Dept. of Earth System Science]|[California Univ., Irvine, CA (United States). Dept. of Ecology and Evolutionary Biology; Pitelka, L.F. (eds.) [Maryland Univ., Frostburg, MD (United States). Appalachian Lab.

    2007-07-01

    Over 100 authors present 25 contributions on the impacts of global change on terrestrial ecosystems including: * key processes of the earth system such as the CO2 fertilization effect, shifts in disturbances and biome distribution, the saturation of the terrestrial carbon sink, and changes in functional biodiversity, * ecosystem services such the production of wheat, pest control, and carbon storage in croplands, and * sensitive regions in the world threaten by rapid changes in climate and land use such as high latitudes ecosystems, tropical forest in Southeast Asia, and ecosystems dominated by Monsoon climate. The book also explores new research developments on spatial thresholds and nonlinearities, the key role of urban development in global biogeochemical processes, and the integration of natural and social sciences to address complex problems of the human-environment system. (orig.)

  10. Comparing marine and terrestrial ecosystems: Implications for the design of coastal marine reserves

    Science.gov (United States)

    Carr, M.H.; Neigel, J.E.; Estes, J.A.; Andelman, S.; Warner, R.R.; Largier, J. L.

    2003-01-01

    Concepts and theory for the design and application of terrestrial reserves is based on our understanding of environmental, ecological, and evolutionary processes responsible for biological diversity and sustainability of terrestrial ecosystems and how humans have influenced these processes. How well this terrestrial-based theory can be applied toward the design and application of reserves in the coastal marine environment depends, in part, on the degree of similarity between these systems. Several marked differences in ecological and evolutionary processes exist between marine and terrestrial ecosystems as ramifications of fundamental differences in their physical environments (i.e., the relative prevalence of air and water) and contemporary patterns of human impacts. Most notably, the great extent and rate of dispersal of nutrients, materials, holoplanktonic organisms, and reproductive propagules of benthic organisms expand scales of connectivity among near-shore communities and ecosystems. Consequently, the "openness" of marine populations, communities, and ecosystems probably has marked influences on their spatial, genetic, and trophic structures and dynamics in ways experienced by only some terrestrial species. Such differences appear to be particularly significant for the kinds of organisms most exploited and targeted for protection in coastal marine ecosystems (fishes and macroinvertebrates). These and other differences imply some unique design criteria and application of reserves in the marine environment. In explaining the implications of these differences for marine reserve design and application, we identify many of the environmental and ecological processes and design criteria necessary for consideration in the development of the analytical approaches developed elsewhere in this Special Issue.

  11. {sup 238}Pu, {sup 239+240}Pu and {sup 241}Am levels in the terrestrial and aquatic environment of the Loire and Garonne rivers basins (France)

    Energy Technology Data Exchange (ETDEWEB)

    Rousseau, G.; Mokili, M.B.; Le Roy, C.; Pagano, V. [SUBATECH/IN2P3 (France); Gontier, G.; Boyer, C. [EDF-DPI-DIN-CIDEN (France); Chardon, P. [CNRS/IN2P3 (France); Hemidy, P.Y. [EDF-DPN-UNIE-GPRE-IEV (France)

    2014-07-01

    Plutonium and americium long-lived alpha emitter isotopes can be found in the environment because of atmospheric global fallout due to thermonuclear tests performed between 1945 and 1980, to the American SNAP 9A satellite explosion in 1964, to the Chernobyl nuclear power plant accident,... In France, the nuclear safety authority does not allow the release of artificial alpha emitters from nuclear power plants. Thus, monitoring is performed to verify the absence of these alpha emitters in liquid discharges to respect the limits set by the regulations. These thresholds ensure a very low dosimetric impact to the population compared to other radionuclides. With the objective of environmental monitoring around nuclear facilities, activity measurements of long-lived alpha emitters are carried out to detect the traces of these radionuclides. Analysis of low activity by alpha spectrometry after chemical steps were performed and used to determine the {sup 238}Pu, {sup 239+240}Pu and {sup 241}Am activities on a large set of environmental solid samples likely to be encountered in environmental monitoring as soils, sediments, terrestrial and aquatic bio-indicators. The samples collected in the terrestrial and aquatic environment of the Loire and Garonne rivers basins (France) was investigated for the 2009-2014 period. It was found that the mean activity concentration of the most frequently detected was for the radionuclide {sup 238}Pu: from <0.00031 to 0.0061 Bq/kg dry in terrestrial samples and from <0.00086 to 0.011 Bq/kg dry in aquatic samples; for the radionuclide {sup 239+240}Pu: from 0.00041 to 0.150 Bq/kg dry in terrestrial samples and from 0.0023 to 0.240 Bq/kg dry in aquatic samples and for the radionuclide {sup 241}Am: from <0.00086 to 0.087 Bq/kg dry in terrestrial samples and from 0.0022 to 0.120 Bq/kg dry in aquatic samples. {sup 238}Pu/{sup 239+240}Pu and {sup 241}Am/{sup 239+240}Pu ratios determined are in accordance with an environmental contamination due to

  12. Low energy electron-initiated ion-molecule reactions of ribose analogues

    International Nuclear Information System (INIS)

    Mozejko, P.

    2003-01-01

    Recent experiments in which plasmid DNA samples were bombarded with low energy ( 2 O, DNA bases, and sugar-phosphate backbone analogues. To this end, the cyclic molecule tetrahydrofuran, and its derivatives, provide useful models for the sugar-like molecules contained in the backbone of DNA. In addition to LEE induced dissociation by processes such as dissociative electron attachment (DEA), molecules may be damaged by ions and neutral species of non-thermal energies created by LEE in the surrounding environment. In this contribution, we investigate with electron stimulated desorption techniques, LEE damage to films of desoxy-ribose analogues in the presence of various molecular coadsorbates, that simulate changes in local molecular environment. In one type of experiments tetrahydrofuran is deposited onto multilayer O2. A desorbed signal of OH - indicates ion-molecule reactions of the type O - + C 4 H 8 O -> OH - + C 4 H 7 O, where the O - was formed initially by DEA to O 2 . Further electron stimulated desorption measurements for tetrahydrofuran and derivatives adsorbed on H 2 O, Kr, N 2 O and CH 3 OH will be presented and discussed

  13. Trophic Transfer of Arsenic from an Aquatic Insect to Terrestrial Insect Predators

    OpenAIRE

    Mogren, Christina L.; Walton, William E.; Parker, David R.; Trumble, John T.

    2013-01-01

    The movement of energy and nutrients from aquatic to terrestrial ecosystems can be substantial, and emergent aquatic insects can serve as biovectors not only for nutrients, but also for contaminants present in the aquatic environment. The terrestrial predators Tenodera aridifolia sinensis (Mantodea: Mantidae) and Tidarren haemorrhoidale (Araneae: Theridiidae) and the aquatic predator Buenoa scimitra (Hemiptera: Notonectidae) were chosen to evaluate the efficacy of arsenic transfer between aqu...

  14. Natural and archaeological analogues: a review

    International Nuclear Information System (INIS)

    Brookins, D.G.

    1987-01-01

    In this chapter natural analogues in the geomedia for various aspects of radioactive waste disposal are discussed. Particular reference is made to the Okla Natural Reactor in Gabon. Igneous contact zones are discussed and natural analogues of waste-form materials. The importance of archaeological remains and anthropogenic materials left by man, in assessing weathering conditions and serving as radioactive waste analogues, is also emphasised. (UK)

  15. Experimental terrestrial soil-core microcosm test protocol. A method for measuring the potential ecological effects, fate, and transport of chemicals in terrestrial ecosystems

    Energy Technology Data Exchange (ETDEWEB)

    Van Voris, P.; Tolle, D.A.; Arthur, M.F.

    1985-06-01

    In order to protect the environment properly and have a realistic appraisal of how a chemical will act in the environment, tests of ecological effects and chemical fate must be performed on complex assemblages of biotic and abiotic components (i.e., microcosms) as well as single species. This protocol is one which could be added to a series of tests recently developed as guidelines for Section 4 of the Toxic Substances Control Act (P.L. 94-469; U.S.C., Section 2601-2629). The terrestrial soil-core microcosm is designed to supply site-specific and possibly regional information on the probable chemical fate and ecological effects resulting from release of a chemical substance to a terrestrial ecosystem. The EPA will use the data resulting from this test system to compare the potential hazards of a chemical with others that have been previously evaluated.

  16. Terrestrial radioactivity monitoring programme (TRAMP) report for 1986

    International Nuclear Information System (INIS)

    1988-01-01

    The Ministry of Agriculture, Fisheries and Food (MAFF) undertakes a comprehensive independent monitoring programme for radioactivity in terrestrial foodstuffs in England and Wales, this report presents the results from the first full year of operation of this programme and complements the data published annually by the Ministry's Directorate of Fisheries Research in respect of the aquatic environment. This work is undertaken in Wales on behalf of the Secretary of State. The Terrestrial Radioactivity Monitoring Programme (TRAMP) concentrates on samples of agricultural produce (milk, crops, meat) collected from the vicinity of the major nuclear sites in England and Wales and is independent of monitoring undertaken for various purposes by site operators. (author)

  17. Multidisciplinary integrated field campaign to an acidic Martian Earth analogue with astrobiological interest: Rio Tinto

    Czech Academy of Sciences Publication Activity Database

    Gómez, F.; Walter, N.; Amils, R.; Rull, F.; Klingelhöfer, G.; Kvíderová, Jana; Sarrazin, P.; Foing, B.; Behar, A.; Fleischer, I.; Parro, V.; Garcia-Villadangos, M.; Blake, D.; Martin-Ramos, J. D.; Direito, S.; Mahapatra, P.; Stam, C.; Venkateswaran, K.; Voytek, M.

    2011-01-01

    Roč. 10, č. 3 (2011), 291-305 ISSN 1473-5504 Institutional research plan: CEZ:AV0Z60050516 Keywords : astrobiology * extreme environments * Earth analogue Subject RIV: EF - Botanics Impact factor: 1.723, year: 2011

  18. Biosphere modeling in waste disposal safety assessments -- An example using the terrestrial-aquatic model of the environment

    International Nuclear Information System (INIS)

    Klos, R.A.

    1998-01-01

    Geological disposal of radioactive wastes is intended to provide long-term isolation of potentially harmful radionuclides from the human environment and the biosphere. The long timescales involved pose unique problems for biosphere modeling because there are considerable uncertainties regarding the state of the biosphere into which releases might ultimately occur. The key to representing the biosphere in long-timescale assessments is the flexibility with which those aspects of the biosphere that are of relevance to dose calculations are represented, and this comes from the way in which key biosphere features, events, and processes are represented in model codes. How this is done in contemporary assessments is illustrated by the Terrestrial-Aquatic Model of the Environment (TAME), an advanced biosphere model for waste disposal assessments recently developed in Switzerland. A numerical example of the release of radionuclides from a subterranean source to an inland valley biosphere is used to illustrate how biosphere modeling is carried out and the practical ways in which meaningful quantitative results can be achieved. The results emphasize the potential for accumulation of radionuclides in the biosphere over long timescales and also illustrate the role of parameter values in such modeling

  19. Generation of terrestrial radiation database in the Larsemann Hills, Antarctica

    International Nuclear Information System (INIS)

    Pal, Rupali; Dhabekar, Bhushan; Jose, Jis Romal; Chinnaesakki, S.; Bakshi, A.K.; Datta, D.; Pradeepkumar, K.S.

    2018-01-01

    Natural background radiation in the environment includes terrestrial radiation, cosmic radiation from space and air activity due to radon/thoron. It is known that cosmic contribution increases near the poles. The terrestrial component is largely due to 232 Th and 238 U series and 40 K. BARC under the cosmic ray dosimetry project with National Centre for Antarctic and Ocean Research (NCAOR) has taken up measurement of natural background radiation at Larsemann Hills, Antarctica. The project includes generation of baseline data on terrestrial radioactivity in water, soil and rock and estimation of cosmic ray doses. Extensive radiation surveys were carried out by the BARC team in the 35 th and 36 th expedition in and around Larsemann hills in East Antarctica where the third Indian station 'Bharati' is situated. This paper presents mapping of terrestrial radiation levels in Antarctica which will help in strengthening the background radiation database and develop a Radiation Informatics System (RIS)

  20. Alligator Rivers Analogue Project. Final Report - Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Duerden, P [Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, NSW (Australia); Lever, D A [AEA Technology, Harwell (United Kingdom); Sverjensky, D A [Johns Hopkins Univ., Baltimore, MD (United States); Townley, L R [Commonwealth Scientific and Industrial Research Organisation (CSIRO), Wembley, WA (Australia). Div. of Water Resources

    1992-07-01

    This summary report, which highlights the work and findings of the Alligator Rivers Analogue Project (ARAP) is one of a series of 16 volumes, listed below. Detailed descriptions and results are provided in Volumes 2 to 16. Full acknowledgment to individual contributions is provided in the individual reports, and in Appendix I of this report. The findings from the technical studies are discussed in the context of assessments of the long-term performance of geological repositories for radioactive wastes, which are being undertaken in many countries. They are also considered in an integrated 'Scenario Development' approach, aimed to understand the formation of the ore deposit. Despite their inherent uncertainties, the findings provide a basis for assessing the way in which radionuclides will migrate in environments with a variety of geologic settings and over a range of different geologic timescales. Thus, section 2 of this report discusses the concept of using uranium deposits as natural analogues and refers to a number of such studies, including those at the Koongarra deposit in the Alligator Rivers Region of the Northern Territory of Australia. Section 3 reviews early scientific work in the Alligator Rivers Region and summarises the results of the analogue studies undertaken between 1981 and 1987 that were funded by the US Nuclear Regulatory Commission (USNRC) and the UK Department of the Environment (UKDoE). Section 4 describes the objectives of ARAP and the manner in which the study was conducted and provides a general outline of the project and a summary of the findings. A general description of the Koongarra ore deposit, the focus of ARAP, is provided in Section 5, with Sections 6-13 providing summaries of the work carried out to characterise the site in detail and provide data for modelling. Sections 14-18 discuss how this data was used in modelling and how the results may be applied for performance assessment studies. Finally, Section 19 considers the

  1. Alligator Rivers Analogue Project. Final Report - Volume 1

    International Nuclear Information System (INIS)

    Duerden, P.; Lever, D.A.; Sverjensky, D.A.; Townley, L.R.

    1992-01-01

    This summary report, which highlights the work and findings of the Alligator Rivers Analogue Project (ARAP) is one of a series of 16 volumes, listed below. Detailed descriptions and results are provided in Volumes 2 to 16. Full acknowledgment to individual contributions is provided in the individual reports, and in Appendix I of this report. The findings from the technical studies are discussed in the context of assessments of the long-term performance of geological repositories for radioactive wastes, which are being undertaken in many countries. They are also considered in an integrated 'Scenario Development' approach, aimed to understand the formation of the ore deposit. Despite their inherent uncertainties, the findings provide a basis for assessing the way in which radionuclides will migrate in environments with a variety of geologic settings and over a range of different geologic timescales. Thus, section 2 of this report discusses the concept of using uranium deposits as natural analogues and refers to a number of such studies, including those at the Koongarra deposit in the Alligator Rivers Region of the Northern Territory of Australia. Section 3 reviews early scientific work in the Alligator Rivers Region and summarises the results of the analogue studies undertaken between 1981 and 1987 that were funded by the US Nuclear Regulatory Commission (USNRC) and the UK Department of the Environment (UKDoE). Section 4 describes the objectives of ARAP and the manner in which the study was conducted and provides a general outline of the project and a summary of the findings. A general description of the Koongarra ore deposit, the focus of ARAP, is provided in Section 5, with Sections 6-13 providing summaries of the work carried out to characterise the site in detail and provide data for modelling. Sections 14-18 discuss how this data was used in modelling and how the results may be applied for performance assessment studies. Finally, Section 19 considers the

  2. Geological trainings for analogue astronauts: Lessons learned from MARS2013 expedition, Morocco

    Science.gov (United States)

    Orgel, C.; Achorner, I.; Losiak, A.; Gołębiowska, I.; Rampey, M.; Groemer, G.

    2013-09-01

    The Austrian Space Forum (OeWF) is a national organisation for space professionals and space enthusiasts. In collaboration with internal partner organisations, the OeWF focuses on Mars analogue research with their space volunteers and organises space-related outreach/education activities and conducts field tests with the Aouda.X and Aouda.S spacesuit simulators in Mars analogue environment. The main project of OeWF is called "PolAres" [1]. As the result of lessons learned from the Río Tinto 2011 expedition [4], we started to organise geological training sessions for the analogue astronauts. The idea was to give them basic geological background to perform more efficiently in the field. This was done in close imitation of the Apollo astronaut trainings that included theoretical lectures (between Jan. 1963-Nov. 1972) about impact geology, igneous petrology of the Moon, geophysics and geochemistry as well as several field trips to make them capable to collect useful samples for the geoscientists on Earth [3] [5]. In the last year the OeWF has organised three geoscience workshops for analogue astronauts as the part of their "astronaut" training. The aim was to educate the participants to make them understand the fundamentals in geology in theory and in the field (Fig. 1.). We proposed the "Geological Experiment Sampling Usefulness" (GESU) experiment for the MARS2013 simulation to improve the efficiency of the geological trainings. This simulation was conducted during February 2013, a one month Mars analogue research was conducted in the desert of Morocco [2] (Fig. 2.).

  3. Transfer analysis of 210Po and 210Pb in the terrestrial environment

    International Nuclear Information System (INIS)

    Persson, B.R.R.

    2013-01-01

    The transfer of 210 Po and 210 Pb between various compartments in the terrestrial environment has been analysed by using published data. The average activity concentration of 210 Po in dry soil is 61 ± 14 Bq.kg -1 (median 44 Bq.kg -1 ). Ground water concentrations of 210 Po in drilled wells might be as high as 6.5 Bq/l. But in regular drinking water it is just about 3-5 mBq/l. The uptake of radionuclides from soil to plant is usually given as the ratio of dry matter radionuclide-activity concentrations of plant (AC plant ) and soil (AC soil ) respectively. This ratio is called the soil transfer factor: STF = AC plant /AC soil . The soil transfer factor varies widely between various types of crops with an average of about 0.056±0.003. The activity concentrations in leafy plants are, however highly affected by the atmospheric deposition of 210 Pb and 210 Po. By comparing the activity concentrations in plants grown on an open field with those grown on a field sheltered by a polyethylene tent, it has been possible to estimate a deposition transfer factor: DTF = Difference of the dry matter activity concentration (Bq.kg -1 ) of plant grown in open field and plants grown in tent shelter, divided by the atmospheric deposition during the vegetation period (Bq.m -2 ). The deposition transfer factor for 210 Pb thus estimated is in the order of 0.5-1.0 (m 2 .kg -1 dry matter) for leafy plants like grass and 0.1-0.5 for less leafy plant and straw. For various grains it is < 0.2 and for root fruits it is < 0.003 (m 2 .kg -1 dry matter). Corresponding values for 210 Po are about a factor 3 times higher. The world average activity concentration of 210 Po in fresh leafy vegetable is estimated to 320±190 mBq.kg -1 , and in cereals and grain products 240±80 mBq.kg -1 . The average activity concentration in milk products is 59 ± 13 mBq.kg -1 and in meat products about 70 ± 39 mBq.kg -1 . The dietary intake of milk and meat products is 170 kg.a - which is the highest of all food

  4. Beyond the principle of plentitude: a review of terrestrial planet habitability.

    Science.gov (United States)

    Gaidos, E; Deschenes, B; Dundon, L; Fagan, K; Menviel-Hessler, L; Moskovitz, N; Workman, M

    2005-04-01

    We review recent work that directly or indirectly addresses the habitability of terrestrial (rocky) planets like the Earth. Habitability has been traditionally defined in terms of an orbital semimajor axis within a range known as the habitable zone, but it is also well known that the habitability of Earth is due to many other astrophysical, geological, and geochemical factors. We focus this review on (1) recent refinements to habitable zone calculations; (2) the formation and orbital stability of terrestrial planets; (3) the tempo and mode of geologic activity (e.g., plate tectonics) on terrestrial planets; (4) the delivery of water to terrestrial planets in the habitable zone; and (5) the acquisition and loss of terrestrial planet carbon and nitrogen, elements that constitute important atmospheric gases responsible for habitable conditions on Earth's surface as well as being the building blocks of the biosphere itself. Finally, we consider recent work on evidence for the earliest habitable environments and the appearance of life itself on our planet. Such evidence provides us with an important, if nominal, calibration point for our search for other habitable worlds.

  5. A Short Term Analogue Memory

    DEFF Research Database (Denmark)

    Shah, Peter Jivan

    1992-01-01

    A short term analogue memory is described. It is based on a well-known sample-hold topology in which leakage currents have been minimized partly by circuit design and partly by layout techniques. Measurements on a test chip implemented in a standard 2.4 micron analogue CMOS process show a droop...

  6. MEASURING AIR AND TERRESTRIAL TRANSPORT COMPANY REPUTATION: TOURISM INTANGIBLES EXPRESSED IN THE DIGITAL ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Célia M.Q. Ramos

    2017-12-01

    Full Text Available The reputation of companies within the transport industry is influenced by competitive dynamics within the sector: low-cost flights, the attractiveness of destinations, online user-generated content about users’ experiences, and more. At the same time, social media provides a means for companies to manage issues of tourism intangibles. Thus, it is relevant to analyse transport reputation in the digital environment, taking into consideration the resources for managing these intangibles. This paper presents a method for measuring transport reputation based on an analysis of tourism consumers’ digital opinions and passengers’ comments about their experiences with these firms. The use of social media, such as TripAdvisor and Facebook, conjugated with business intelligence tools and complemented by data mining techniques, can contribute to the development of metrics that consider intangibles like emotions and experiences, with the aim of measuring, analysing, and visualizing the complex relationships between these intangibles and transport companies’ reputations. The results present the impacts of these intangibles through clusters and positioning maps focusing on these issues. This investigation contributes to our knowledge about airlines and terrestrial transport companies that seek to differentiate their positioning in tourism markets through their reputations.

  7. Examining predator–prey body size, trophic level and body mass across marine and terrestrial mammals

    Science.gov (United States)

    Tucker, Marlee A.; Rogers, Tracey L.

    2014-01-01

    Predator–prey relationships and trophic levels are indicators of community structure, and are important for monitoring ecosystem changes. Mammals colonized the marine environment on seven separate occasions, which resulted in differences in species' physiology, morphology and behaviour. It is likely that these changes have had a major effect upon predator–prey relationships and trophic position; however, the effect of environment is yet to be clarified. We compiled a dataset, based on the literature, to explore the relationship between body mass, trophic level and predator–prey ratio across terrestrial (n = 51) and marine (n = 56) mammals. We did not find the expected positive relationship between trophic level and body mass, but we did find that marine carnivores sit 1.3 trophic levels higher than terrestrial carnivores. Also, marine mammals are largely carnivorous and have significantly larger predator–prey ratios compared with their terrestrial counterparts. We propose that primary productivity, and its availability, is important for mammalian trophic structure and body size. Also, energy flow and community structure in the marine environment are influenced by differences in energy efficiency and increased food web stability. Enhancing our knowledge of feeding ecology in mammals has the potential to provide insights into the structure and functioning of marine and terrestrial communities. PMID:25377460

  8. Terrestrial Gamma Radiation Exposure Measurement and Risk Estimates in the Environments of Major Industries In Ota, Nigeria

    Directory of Open Access Journals (Sweden)

    Abodunrin Oluwasayo Peter

    2016-11-01

    Full Text Available When fast estimates are required, the in-situ method is more appropriate as this allows for quick results; preventing further exposure of the public and permitting quick intervention. Measurements of the terrestrial gamma radiation exposure have been carried out in the environments of major industries in Ota using a portable survey meter. The motivation for this study resulted from the uncertainty in the general public opinion on the effect of the presence, and activities of some of these industries in their environment. Measurements were taken twice daily within the vicinity of each industry to determine the dose levels. The mean values obtained range from 0.11 – 1.80 µSv/h. These values are within the results obtained from normal background areas except for site number 10. Annual effective dose values range from 0.25 – 5.21 mSv with a mean value of 1.21 mSv. Routine activities in some of these environments may have contributed significantly to the ambient natural background radiation resulting in high values as obtained in some of these locations. The total risks disparately estimated for cancer and genetic effects resulting from the results obtained range from 0.17 x 10-4 – 3.80 x 10-4 with a mean value of 0.94 x 10-4. These levels are within the range of the average annual risk for accidental death for all industries.

  9. The network to review natural analogue studies and their applications to repository safety assessment and public communication (NAnet)

    Energy Technology Data Exchange (ETDEWEB)

    Miller, W.M.; Hooker, P.J. [ENVIROS Consulting ltd, 61, the Shore Leith, UK-0 EH6 6RA Edinburgh (United Kingdom)

    2004-07-01

    Analogue information can increase our conceptual understanding of long-term repository behaviour in support of post-closure performance assessment (PA), provide quantitative data for PA models and provide ways of communicating safety information to non-specialist audiences. These functions of analogue studies have, however, received too little attention in PA reports and safety cases. Many analogue studies have been undertaken in the last two decades costing tens of millions of euros, and these have covered a wide range of phenomena such as uranium ore deposition, natural fission reactors, natural nuclide migration, contaminant containment by clays and sediments, preservation of ancient fossil trees and buried artefacts etc. The different uses of analogues would be easier to manage if a single database of quality approved analogue information were to be created. NAnet, a Thematic Network within the 5. EURATOM FP is aiming to promote more considered applications of analogues in performance and safety assessments and in audience dialogue. NAnet intends critically to review a number of analogue studies in terms of their relevance and limitations to different repository concepts and environments and with regard to their applications in performance assessments, safety cases and communication. On the basis of these reviews, a simple digital database is being developed for the PA community which will allow PA modelers to make quicker and wider use of natural analogue information in performance and safety assessments. It is expected that some of these tools will help radioactive waste institutions to make better use of natural analogue information for communication with different audiences, including the public. (authors)

  10. Analogue to Digital and Digital to Analogue Converters (ADCs and DACs): A Review Update

    CERN Document Server

    Pickering, J.

    2015-06-15

    This is a review paper updated from that presented for CAS 2004. Essentially, since then, commercial components have continued to extend their performance boundaries but the basic building blocks and the techniques for choosing the best device and implementing it in a design have not changed. Analogue to digital and digital to analogue converters are crucial components in the continued drive to replace analogue circuitry with more controllable and less costly digital processing. This paper discusses the technologies available to perform in the likely measurement and control applications that arise within accelerators. It covers much of the terminology and 'specmanship' together with an application-oriented analysis of the realisable performance of the various types. Finally, some hints and warnings on system integration problems are given.

  11. Debris disks as signposts of terrestrial planet formation

    Science.gov (United States)

    Raymond, S. N.; Armitage, P. J.; Moro-Martín, A.; Booth, M.; Wyatt, M. C.; Armstrong, J. C.; Mandell, A. M.; Selsis, F.; West, A. A.

    2011-06-01

    There exists strong circumstantial evidence from their eccentric orbits that most of the known extra-solar planetary systems are the survivors of violent dynamical instabilities. Here we explore the effect of giant planet instabilities on the formation and survival of terrestrial planets. We numerically simulate the evolution of planetary systems around Sun-like stars that include three components: (i) an inner disk of planetesimals and planetary embryos; (ii) three giant planets at Jupiter-Saturn distances; and (iii) an outer disk of planetesimals comparable to estimates of the primitive Kuiper belt. We calculate the dust production and spectral energy distribution of each system by assuming that each planetesimal particle represents an ensemble of smaller bodies in collisional equilibrium. Our main result is a strong correlation between the evolution of the inner and outer parts of planetary systems, i.e. between the presence of terrestrial planets and debris disks. Strong giant planet instabilities - that produce very eccentric surviving planets - destroy all rocky material in the system, including fully-formed terrestrial planets if the instabilities occur late, and also destroy the icy planetesimal population. Stable or weakly unstable systems allow terrestrial planets to accrete in their inner regions and significant dust to be produced in their outer regions, detectable at mid-infrared wavelengths as debris disks. Stars older than ~100 Myr with bright cold dust emission (in particular at λ ~ 70 μm) signpost dynamically calm environments that were conducive to efficient terrestrial accretion. Such emission is present around ~16% of billion-year old Solar-type stars. Our simulations yield numerous secondary results: 1) the typical eccentricities of as-yet undetected terrestrial planets are ~0.1 but there exists a novel class of terrestrial planet system whose single planet undergoes large amplitude oscillations in orbital eccentricity and inclination; 2) by

  12. Quantum analogue computing.

    Science.gov (United States)

    Kendon, Vivien M; Nemoto, Kae; Munro, William J

    2010-08-13

    We briefly review what a quantum computer is, what it promises to do for us and why it is so hard to build one. Among the first applications anticipated to bear fruit is the quantum simulation of quantum systems. While most quantum computation is an extension of classical digital computation, quantum simulation differs fundamentally in how the data are encoded in the quantum computer. To perform a quantum simulation, the Hilbert space of the system to be simulated is mapped directly onto the Hilbert space of the (logical) qubits in the quantum computer. This type of direct correspondence is how data are encoded in a classical analogue computer. There is no binary encoding, and increasing precision becomes exponentially costly: an extra bit of precision doubles the size of the computer. This has important consequences for both the precision and error-correction requirements of quantum simulation, and significant open questions remain about its practicality. It also means that the quantum version of analogue computers, continuous-variable quantum computers, becomes an equally efficient architecture for quantum simulation. Lessons from past use of classical analogue computers can help us to build better quantum simulators in future.

  13. Iodine in the environment revisited

    International Nuclear Information System (INIS)

    Christiansen, J.V.; Carlsen, L.

    1989-05-01

    The report gives an overview of the environmental cycle of iodine, especially focusing on the possible reactions being responsible for the retention of iodine in the terrestrial environment. During the last two decades evidence for the presence of iodine in soil as organically bound has been presented. The major part of inorganic iodine in the terrestrial environment will, under physical and chemical conditions normally prevailing, exist as iodide. No evidence for a direct reaction between iodide and organic material has been presented, whereas strong support for the engagement of microbial activity in the formation of organic iodine compounds in soil has been obtained. Incorporation of iodine in humic substances as a result of enzymatic catalysis, involving an enzyme of the perozidase group apperas reasonable. It is concluded that microbiological activity involving extracellular enzymes most probably is responsible for the possible retention of iodine in the terrestrial environment. It is suggested that these reactions in detail should be studied experimentally. (author) 3 tabs., 2 ills., 51 refs

  14. Ecological land classification and terrestrial environment effects assessment for the Port Hope and Port Granby projects

    International Nuclear Information System (INIS)

    Taylor, M.; Wittkugel, U.; Kleb, H.

    2006-01-01

    The Ecological Land Classification system was developed to provide a standardized methodology for describing plant communities and wildlife habitat in southern Ontario. The method employs a hierarchical classification system. It can be applied at different levels of accuracy, i.e., at regional, sub-regional, and local scales with an increasing differentiation of vegetation communities. The standardization of the approach permits a comparison of vegetation communities from different sites and an evaluation of the rarity of these communities within the province. Further, the approach facilitates the monitoring of changes in terrestrial communities with time. These characteristics make Ecological Land Classification mapping a useful tool for environmental assessment such as the ones undertaken for the Port Hope and Port Granby Long-Term Waste Management Projects, which were conducted pursuant to the Canadian Environmental Assessment Act 1992. In the context of the Environmental Assessment for the Port Hope and Port Granby Projects, an Ecological Land Classification study was undertaken to characterize the terrestrial environment at regional, local and site levels. Vegetation patches (polygons) were delineated on the basis of air photo interpretation. The individual polygons were then visited for detailed inventory and classified to the most detailed level; that is to the vegetation type. Plant communities were then compared with those listed in the Ontario Natural Heritage Information Centre database to determine their rarity and to determine where they rank as Valued Ecosystem Components. Ecological Land Classification mapping results were used in the assessment of effects to Valued Ecosystem Components. A spatial analysis of the digitized vegetation maps showed the geographic extent of habitat losses and impairments due to various project works and activities. Landscape rehabilitation strategies and concepts were subsequently developed based on Ecological Land

  15. Clonal integration supports the expansion from terrestrial to aquatic environments of the amphibious stoloniferous herb Alternanthera philoxeroides.

    Science.gov (United States)

    Wang, N; Yu, F-H; Li, P-X; He, W-M; Liu, J; Yu, G-L; Song, Y-B; Dong, M

    2009-05-01

    Effects of clonal integration on land plants have been extensively studied, but little is known about the role in amphibious plants that expand from terrestrial to aquatic conditions. We simulated expansion from terrestrial to aquatic habitats in the amphibious stoloniferous alien invasive alligator weed (Alternanthera philoxeroides) by growing basal ramets of clonal fragments in soils connected (allowing integration) or disconnected (preventing integration) to the apical ramets of the same fragments submerged in water to a depth of 0, 5, 10 or 15 cm. Clonal integration significantly increased growth and clonal reproduction of the apical ramets, but decreased both of these characteristics in basal ramets. Consequently, integration did not affect the performance of whole clonal fragments. We propose that alligator weed possesses a double-edged mechanism during population expansion: apical ramets in aquatic habitats can increase growth through connected basal parts in terrestrial habitats; however, once stolon connections with apical ramets are lost by external disturbance, the basal ramets in terrestrial habitats increase stolon and ramet production for rapid spreading. This may contribute greatly to the invasiveness of alligator weed and also make it very adaptable to habitats with heavy disturbance and/or highly heterogeneous resource supply.

  16. BALANOL ANALOGUES

    DEFF Research Database (Denmark)

    1997-01-01

    The present invention relates to a solid phase methodology for the preparation of a combinatorial library of structural analogues of the natural product balanol (ophiocordin, azepinostatin), which is a protein kinase C (PKC) and protein kinase A (PKA) inhibitor. The method comprises solid...

  17. EVALUATION OF MICROBIAL SURVIVAL IN EXTRATERRESTRIAL ENVIRONMENTS

    Directory of Open Access Journals (Sweden)

    Betül BULUÇ

    2012-08-01

    Full Text Available In this paper, the space environments where microbial terrestrial life could form and evolve in, were evaluted with the base of the physical and chemical properties. In addition, Earthial microbial life formation conditions in the interstellar medium and the other planets are investigated and the survival of microorganisms in the space environments are questioned. As a result, considering the aspects of terrestrial microbial life, we suggest that the space environment and other planets could not be a habitat for Earthial microorganisms.

  18. Glacimarine environments: processes and sediments

    National Research Council Canada - National Science Library

    Dowdeswell, J. A; Scourse, James D

    1990-01-01

    This volume examines the processes responsible for sedimentation in modern glaciomarine environments, and how such modern studies can be used as analogues in the interpretation of ancient glaciomarine sequences...

  19. Cephalostatin analogues--synthesis and biological activity.

    Science.gov (United States)

    Flessner, Timo; Jautelat, Rolf; Scholz, Ulrich; Winterfeldt, Ekkehard

    2004-01-01

    Starting off in the early 90's the field of cephalostatin analogues has continually expanded over the last 10 years. First syntheses prepared symmetric analogues like 14b (119) and 26 (65), which were subsequently desymmetrized to provide analogues like beta-hydroxy ketone 31 (19). Importantly the straightforward approach provided already compounds with mu-molar potency and the same pattern of activity as cephalostatin 1 (1) (see Chapter 2.1). Chemically more demanding, two new methods for the directed synthesis of (bissteroidal) pyrazines were devised and subsequently applied to a wide variety of differently functionalized coupling partners. These new methods allowed for the synthesis of various analogues (Chapter 2.2.; and, last but not least, for the totals synthesis of several cephalostatin natural products; Chapter 1.). Functionalization and derivatization of the 12-position was performed (Chapter 2.1 and 3) and synthetic approaches to establish the D-ring double bond were successfully investigated (Chapter 3). [figure: see text] Dealing synthetically with the spiroketal moiety, novel oxidative opening procedures on monomeric delta 14, 15-steroids were devised as well as intensive studies regarding spiroketal synthesis and spiroketal rearrangements were conducted (Chapter 3.2. and 4.). Last but not least direct chemical modification of ritterazines and cephalostatins were studied, which provided a limited number of ritterazine analogues (Chapter 4.). All these synthetic activities towards analogues are summarized in Fig. 18. During this period of time the growing number of cephalostatins and ritterazines on the one hand and of analogues on the other hand provided several SAR trends, which can guide future analogue synthesis. The combined SAR findings are displayed in Fig. 19. So far it is apparent that: Additional methoxylations or hydroxylations in the steroidal A ring core structure (1-position) are slightly decreasing activity (compare cephalostatin 1 1 to

  20. Analogue to Digital and Digital to Analogue (AD/DA) Conversion Techniques: An Overview

    CERN Multimedia

    CERN. Geneva

    2002-01-01

    The basic ideas behind modern Analogue to Digital and Digital to Analogue (AD/DA) conversion methods will be introduced: a general view of the importance of these devices will be given, along with the digital representation of time-varying, real-world analogue signals. Some CERN applications will be outlined. The variety of conversion methods, their limitations, error sources and measurement methods will form the major part of this presentation. A review of the technological progress in this field over the last 30 years will be presented, concluding with the present 'state of the art' and a quick look at what is just around the corner. This Technical Training Seminar is in the framework of the FEED-2002 Lecture Series, and it is a prerequisite to attending to any of the FEED-2002 Terms. FEED-2002 is a two-term course that will review the techniques dealing with closed loop systems, focussing on time-invariant linear systems. (free attendance, no registration required) More information on the FEED-2002 ...

  1. A terrestrial Eocene stack: tying terrestrial lake ecology to marine carbon cycling through the Early Eocene Climatic Optimum

    Science.gov (United States)

    Grogan, D. S.; Whiteside, J. H.; Musher, D.; Rosengard, S. Z.; Vankeuren, M. A.; Pancost, R. D.

    2010-12-01

    The lacustrine Green River Formation is known to span ≥15 million years through the early-middle Eocene, and recent work on radioisotopic dating has provided a framework on which to build ties to the orbitally-tuned marine Eocene record. Here we present a spliced stack of Fischer assay data from drilled cores of the Green River Formation that span both an East-West and a North-South transect of the Uinta Basin of Utah. Detailed work on two cores demonstrate that Fischer assay measurements covary with total organic carbon and bulk carbon isotopes, allowing us to use Fisher assay results as a representative carbon cycling proxy throughout the stack. We provide an age model for this core record by combining radioisotopic dates of tuff layers with frequency analysis of Fischer assay measurements. Identification of orbital frequencies tied directly to magnetochrons through radioisotopic dates allows for a direct comparison of the terrestrial to the marine Eocene record. Our analysis indicates that the marker beds used to correlate the stack cores represent periods of enhanced lake productivity and extreme carbon burial; however, unlike the hyperthermal events that are clearly marked in the marine Eocene record, the hydrocarbon-rich "Mahogany Bed" period of burial does not correspond to a clear carbon isotope excursion. This suggests that the terrestrial realm may have experienced extreme ecological responses to relatively small perturbations in the carbon cycle during the Early Eocene Climatic Optimum. To investigate the ecological responses to carbon cycle perturbations through the hydrocarbon rich beds, we analyzed a suite of microbial biomarkers, finding evidence for cyanobacteria, dinoflagellates, and potentially green sulfur bacteria. These taxa indicate fluctuating oxic/anoxic conditions in the lake during abrupt intervals of carbon burial, suggesting a lake biogeochemical regime with no modern analogues.

  2. Nitrogen and carbon isotopic composition of bone collagen from marine and terrestrial animals

    International Nuclear Information System (INIS)

    Schoeninger, M.J.; DeNiro, M.J.

    1984-01-01

    The stable nitrogen and carbon isotope ratios of bone collagen prepared from more than 100 animals representing 66 species of birds, fish, and mammals are presented. The delta 15 N values of bone collagen from animals that fed exclusively in the marine environment are, on average, 9 per mille more positive than those from animals that fed exclusively in the terrestrial environment: ranges for the two groups overlap by less than 1 per mille. Bone collagen delta 15 N values also serve to separate marine fish from the small number of freshwater fish we analyzed. The bone collagen delta 15 N values of birds and fish that spent part of their life cycles feeding in the marine environment and part in the freshwater environment are intermediate between those of animals that fed exclusively in one or the other system. Further, animals that fed at successive trophic levels in the marine and terrestrial environment are separated, on average, by a 3 per mille difference in the delta 15 N values of their bone collagen. Results are given and discussed. (author)

  3. Examining predator-prey body size, trophic level and body mass across marine and terrestrial mammals.

    Science.gov (United States)

    Tucker, Marlee A; Rogers, Tracey L

    2014-12-22

    Predator-prey relationships and trophic levels are indicators of community structure, and are important for monitoring ecosystem changes. Mammals colonized the marine environment on seven separate occasions, which resulted in differences in species' physiology, morphology and behaviour. It is likely that these changes have had a major effect upon predator-prey relationships and trophic position; however, the effect of environment is yet to be clarified. We compiled a dataset, based on the literature, to explore the relationship between body mass, trophic level and predator-prey ratio across terrestrial (n = 51) and marine (n = 56) mammals. We did not find the expected positive relationship between trophic level and body mass, but we did find that marine carnivores sit 1.3 trophic levels higher than terrestrial carnivores. Also, marine mammals are largely carnivorous and have significantly larger predator-prey ratios compared with their terrestrial counterparts. We propose that primary productivity, and its availability, is important for mammalian trophic structure and body size. Also, energy flow and community structure in the marine environment are influenced by differences in energy efficiency and increased food web stability. Enhancing our knowledge of feeding ecology in mammals has the potential to provide insights into the structure and functioning of marine and terrestrial communities. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  4. Collection, Processing, and Accuracy of Mobile Terrestrial Lidar Survey Data in the Coastal Environment

    Science.gov (United States)

    2017-04-01

    technical report is to present how elevation data is collected along the coast using terrestrial lidar scanners coupled with a global position system...vi 1 Introduction ...Classified .las point cloud ........................................................................................... 23 5.2 Digital elevation model

  5. Plastic bag derived-microplastics as a vector for metal exposure in terrestrial invertebrates

    OpenAIRE

    Hodson, Mark Edward; Duffus-Hodson, Calum; Clark, Andy; Prendergast-Miller, Miranda Tendai; Thorpe, Karen Louise

    2017-01-01

    Microplastics are widespread contaminants in terrestrial environments but comparatively little is known about interactions between microplastics and common terrestrial contaminants such as zinc (Zn). In adsorption experiments fragmented HDPE bags c. 1 mm2 in size showed similar sorption characteristics to soil. However, when present in combination with soil, concentrations of adsorbed Zn on a per mass basis were over an order of magnitude lower on microplastics . Desorption of the Zn was mini...

  6. Endogenous circadian regulation of carbon dioxide exchange in terrestrial ecosystems

    Science.gov (United States)

    We tested the hypothesis that diurnal changes in terrestrial CO2 exchange are driven exclusively by the direct effect of the physical environment on plant physiology. We failed to corroborate this assumption, finding instead large diurnal fluctuations in whole ecosystem carbon assimilation across a ...

  7. Ageing effects on image sensors due to terrestrial cosmic radiation

    NARCIS (Netherlands)

    Nampoothiri, G.G.; Horemans, M.L.R.; Theuwissen, A.J.P.

    2011-01-01

    We analyze the “ageing” effect on image sensors introduced by neutrons present in natural (terrestrial) cosmic environment. The results obtained at sea level are corroborated for the first time with accelerated neutron beam tests and for various image sensor operation conditions. The results reveal

  8. Using the Moon as a high-fidelity analogue environment to study biological and behavioral effects of long-duration space exploration

    Science.gov (United States)

    Goswami, Nandu; Roma, Peter G.; De Boever, Patrick; Clément, Gilles; Hargens, Alan R.; Loeppky, Jack A.; Evans, Joyce M.; Peter Stein, T.; Blaber, Andrew P.; Van Loon, Jack J. W. A.; Mano, Tadaaki; Iwase, Satoshi; Reitz, Guenther; Hinghofer-Szalkay, Helmut G.

    2012-12-01

    Due to its proximity to Earth, the Moon is a promising candidate for the location of an extra-terrestrial human colony. In addition to being a high-fidelity platform for research on reduced gravity, radiation risk, and circadian disruption, the Moon qualifies as an isolated, confined, and extreme (ICE) environment suitable as an analog for studying the psychosocial effects of long-duration human space exploration missions and understanding these processes. In contrast, the various Antarctic research outposts such as Concordia and McMurdo serve as valuable platforms for studying biobehavioral adaptations to ICE environments, but are still Earth-bound, and thus lack the low-gravity and radiation risks of space. The International Space Station (ISS), itself now considered an analog environment for long-duration missions, better approximates the habitable infrastructure limitations of a lunar colony than most Antarctic settlements in an altered gravity setting. However, the ISS is still protected against cosmic radiation by the Earth magnetic field, which prevents high exposures due to solar particle events and reduces exposures to galactic cosmic radiation. On Moon the ICE environments are strengthened, radiations of all energies are present capable of inducing performance degradation, as well as reduced gravity and lunar dust. The interaction of reduced gravity, radiation exposure, and ICE conditions may affect biology and behavior - and ultimately mission success - in ways the scientific and operational communities have yet to appreciate, therefore a long-term or permanent human presence on the Moon would ultimately provide invaluable high-fidelity opportunities for integrated multidisciplinary research and for preparations of a manned mission to Mars.

  9. Transuranic elements in terrestrial animals and the environment: an introduction

    International Nuclear Information System (INIS)

    Potter, G.D.

    1977-01-01

    This discussion provides background information to the session on the ''Transuranic Elements in Terrestrial Animals.'' Briefly outlined are some of the historical events leading to the introduction and dispersion of the transuranic elements into the biosphere, to the establishment of the Nevada Applied Ecology Group (NAEG), and to the studies conducted by the Environmental Monitoring and Support Laboratory (EMSL-LV) and the University of Nevada-Las Vegas involving the transuranics distributed by the ''safety shots'' and the nuclear weapons testing program at the Nevada Test Site and the Tonopah Test Range. These studies are described in relation to the overall objectives of the NAEG program. Other potential sources of the transuranic radionuclides are also discussed

  10. Linking terrestrial and marine conservation planning and threats analysis.

    Science.gov (United States)

    Tallis, Heather; Ferdaña, Zach; Gray, Elizabeth

    2008-02-01

    The existence of the Gulf of Mexico dead zone makes it clear that marine ecosystems can be damaged by terrestrial inputs. Marine and terrestrial conservation planning need to be aligned in an explicit fashion to fully represent threats to marine systems. To integrate conservation planning for terrestrial and marine systems, we used a novel threats assessment that included 5 cross-system threats in a site-prioritization exercise for the Pacific Northwest coast ecoregion (U.S.A.). Cross-system threats are actions or features in one ecological realm that have effects on species in another realm. We considered bulkheads and other forms of shoreline hardening threats to terrestrial systems and roads, logging, agriculture, and urban areas threats to marine systems. We used 2 proxies of freshwater influence on marine environments, validated against a mechanistic model and field observations, to propagate land-based threats into marine sites. We evaluated the influence of cross-system threats on conservation priorities by comparing MARXAN outputs for 3 scenarios that identified terrestrial and marine priorities simultaneously: (1) no threats, (2) single-system threats, and (3) single- and cross-system threats. Including cross-system threats changed the threat landscape dramatically. As a result the best plan that included only single-system threats identified 323 sites (161,500 ha) at risk from cross-system threats. Including these threats changed the location of best sites. By comparing the best and sum solutions of the single- and cross-system scenarios, we identified areas ideal for preservation or restoration through integrated management. Our findings lend quantitative support to the call for explicitly integrated decision making and management action in terrestrial and marine ecosystems.

  11. International video project on natural analogues

    International Nuclear Information System (INIS)

    Guentensperger, Marcel

    1993-01-01

    A natural analogue can be defined as a natural process which has occurred in the past and is studied in order to test predictions about the future evolution of similar processes. In recent years, natural analogues have been used increasingly to test the mathematical models required for repository performance assessment. Analogues are, however, also of considerable use in public relations as they allow many of the principles involved in demonstrating repository safety to be illustrated in a clear manner using natural systems with which man is familiar. The international Natural Analogue Working Group (NAWG), organised under the auspices of the CEC, has recognised that such PR applications are of considerable importance and should be supported from a technical level. At the NAWG meeting in Pitlochry, Scotland (June 1990), it was recommended that the possibilities for making a video film on this topic be investigated and Nagra was requested to take the lead role in setting up such a project

  12. Diversity and disparity of sparassodonts (Metatheria) reveal non-analogue nature of ancient South American mammalian carnivore guilds

    Science.gov (United States)

    Dolgushina, Tatiana; Wesley, Gina

    2018-01-01

    This study investigates whether terrestrial mammalian carnivore guilds of ancient South America, which developed in relative isolation, were similar to those of other continents. We do so through analyses of clade diversification, ecomorphology and guild structure in the Sparassodonta, metatherians that were the predominant mammalian carnivores of pre-Pleistocene South America. Body mass and 16 characters of the dentition are used to quantify morphological diversity (disparity) in sparassodonts and to compare them to extant marsupial and placental carnivores and extinct North American carnivoramorphans. We also compare trophic diversity of the Early Miocene terrestrial carnivore guild of Santa Cruz, Argentina to that of 14 modern and fossil guilds from other continents. We find that sparassodonts had comparatively low ecomorphological disparity throughout their history and that South American carnivore palaeoguilds, as represented by that of Santa Cruz, Argentina, were unlike modern or fossil carnivore guilds of other continents in their lack of mesocarnivores and hypocarnivores. Our results add to a growing body of evidence highlighting non-analogue aspects of extinct South American mammals and illustrate the dramatic effects that historical contingency can have on the evolution of mammalian palaeocommunities. PMID:29298933

  13. Ecological effects from transuranium elements in terrestrial environment

    International Nuclear Information System (INIS)

    Uiker, F.U.

    1985-01-01

    To understand ecological effects from transuranium elements in environment it is necessary to know how their chemical, physical and biological behaviour depends on duration of their being in natural environment. It is necesary to take into account that behaviour of transuranium elements in environment depends on physical and chemical forms of a nuclide as well as on characteristics of ecosystem. Radiation dose of certain tissues plays an essential role here but dose distribution is especially complicated for relatively non-soluble α-irradiators

  14. Radioactivity in the terrestrial environment; review of UK research 1993-1996 and recommendations for future work

    International Nuclear Information System (INIS)

    1997-03-01

    The national Radioactivity Research and Environmental Monitoring Committee (RADREM) provides a forum for liaison on UK research and monitoring in the radioactive substances and radioactive waste management fields. It is subscribed to by Government departments, national regulatory bodies, the UK nuclear industry and other bodies with relevant research sponsorship and monitoring interests. A key function of the RADREM committee is to ensure that there is no unnecessary overlap between or significant omission from the research sponsored by the organisations represented upon it. To this end periodic reviews of research sector programmes are carried out. This report covers a review which was carried out by the Terrestrial Environment Sub-Committee (TESC) of RADREM for the period 1993-1996. In particular possible future research requirements are considered and evaluated. Such omissions are as identified do not reflect Sub-Committee views on the adequacy of any individual organisations research programme. Rather they should be seen as areas where gaps in knowledge may exist, which all organisations are free to consider and prioritise in the formulation of their future research requirements. (author)

  15. Exploration of charge states of balanol analogues acting as ATP-competitive inhibitors in kinases.

    Science.gov (United States)

    Hardianto, Ari; Yusuf, Muhammad; Liu, Fei; Ranganathan, Shoba

    2017-12-28

    assignments of ligands are important to obtain predicted binding energy values from MD simulations that reflect experimental values. Both fluorination and the local enzymatic environment of the ATP site can influence the exact charge states of balanol analogues. Overall, this study is highly valuable for further rational design of potent balanol analogues selective to PKCε.

  16. Influence of microplastics on feeding and energy reserves of terrestrial isopods Porcellio scaber

    OpenAIRE

    Crepulja, Tanja

    2016-01-01

    The main focus of this research was microplastic, the small plastic particles less than than 5 mm in diameter. Microplastics can also be obtained directly in the form of fibers from washing, as particles from cosmetic products or as by-product of larger plastic parts. In our thesis we wanted to prove, that the current concentration of microplastics in the environment (compost heap) has an impact on terrestrial organisms, in this case terrestrial isopod crustaceans, Porcelio scaber. We hypothe...

  17. NASA HRP Immunology Discipline - Use of Terrestrial Analogs

    Science.gov (United States)

    Crucian, Brian

    2014-01-01

    Due to the cost and operational constraints, as well as technical implementation limitations, it is desirous to perform relevant space physiology investigations first in terrestrial 'space analogs'. This is particularly true for initial investigations, which may then provide appropriate focus for subsequent flight investigations, or for mechanistic investigations that simply cannot be performed during spaceflight. Appropriate analog choice is extremely important. There are a wide variety of terrestrial space analogs, each relevant to a particular physiological discipline (or disciplines) and each with a particular fidelity (or lack thereof) to spaceflight, and each with unique operational constraints. The HRP Immunology Discipline is tasked with managing the HRP Risk concerning clinical risk for Astronaut crews related to spaceflight-associated immune dysregulation. Such dysregulation has been documented to occur during spaceflight, and found to persist for the duration of a 6-month ISS mission. Studies continue to characterize the onorbit phenomenon, but it generally consists of diminished immunocyte function, dysregulated cytokine profiles, and persistent herpesvirus reactivation. Causes are thought to synergistically include microgravity, psychological or physiological stress, radiation, and/or circadian misalignment. An appropriate terrestrial analog for immune dysregulation would replicate as many of these influences as possible. Such analogs may include clinostat or bioreactor cell culture (microgravity), hindlimb suspension (stress, fluid shifts, hypokinesis), or human deployment to remote or extreme environments (isolation, stress, circadian). Also, the laboratory setting may be used as an analog, or to augment analogs, such as sleep deprivation/misalignment or human centrifugation to replicate gravitational stress. As an appropriate example of a NASA Disciplines use of Terrestrial space analogs, this talk will discuss spaceflight associated immune

  18. Analogue Hawking radiation from astrophysical black-hole accretion

    International Nuclear Information System (INIS)

    Das, Tapas K

    2004-01-01

    We show that spherical accretion onto astrophysical black holes can be considered as a natural example of an analogue system. We provide, for the first time, an exact analytical scheme for calculating the analogue Hawking temperature and surface gravity for general relativistic accretion onto astrophysical black holes. Our calculation may bridge the gap between the theory of transonic astrophysical accretion and the theory of analogue Hawking radiation. We show that the domination of the analogue Hawking temperature over the actual Hawking temperature may be a real astrophysical phenomenon, though observational tests of this fact will at best be difficult and at worst might prove to be impossible. We also discuss the possibilities of the emergence of analogue white holes around astrophysical black holes. Our calculation is general enough to accommodate accreting black holes with any mass

  19. Assessment of Light Environment Variability in Broadleaved Forest Canopies Using Terrestrial Laser Scanning

    Directory of Open Access Journals (Sweden)

    Dimitry Van der Zande

    2010-06-01

    Full Text Available Light availability inside a forest canopy is of key importance to many ecosystem processes, such as photosynthesis and transpiration. Assessment of light availability and within-canopy light variability enables a more detailed understanding of these biophysical processes. The changing light-vegetation interaction in a homogeneous oak (Quercus robur L. stand was studied at different moments during the growth season using terrestrial laser scanning datasets and ray tracing technology. Three field campaigns were organized at regular time intervals (24 April 2008; 07 May 2008; 23 May 2008 to monitor the increase of foliage material. The laser scanning data was used to generate 3D representations of the forest stands, enabling structure feature extraction and light interception modeling, using the Voxel-Based Light Interception Model (VLIM. The VLIM is capable of estimating the relative light intensity or Percentage of Above Canopy Light (PACL at any arbitrary point in the modeled crown space. This resulted in a detailed description of the dynamic light environments inside the canopy. Mean vertical light extinction profiles were calculated for the three time frames, showing significant differences in light attenuation by the canopy between April 24 on the one hand, and May 7 and May 23 on the other hand. The proposed methodology created the opportunity to link these within-canopy light distributions to the increasing amount of photosynthetically active leaf material and its distribution in the considered 3D space.

  20. Strong climate coupling of terrestrial and marine environments in the Miocene of northwest Europe

    NARCIS (Netherlands)

    Donders, T.H.; Weijers, J.W.H.; Munsterman, D.K.; Kloosterboer-van Hoeve, M.L.; Buckles, L.K.; Pancost, R.D.; Schouten, S.; Sinninghe Damsté, J.S.; Brinkhuis, H.

    2009-01-01

    A palynological and organic geochemical record from a shallow marine paleoenvironmental setting in SE Netherlands documents the coupled marine and terrestrial climate evolution from the late Burdigalian (∼ 17 Ma) through the early Zanclean (∼ 4.5 Ma). Proxy climate records show several coeval

  1. Fish embryos on land: terrestrial embryo deposition lowers oxygen uptake without altering growth or survival in the amphibious fish Kryptolebias marmoratus.

    Science.gov (United States)

    Wells, Michael W; Turko, Andy J; Wright, Patricia A

    2015-10-01

    Few teleost fishes incubate embryos out of water, but the oxygen-rich terrestrial environment could provide advantages for early growth and development. We tested the hypothesis that embryonic oxygen uptake is limited in aquatic environments relative to air using the self-fertilizing amphibious mangrove rivulus, Kryptolebias marmoratus, which typically inhabits hypoxic, water-filled crab burrows. We found that adult mangrove rivulus released twice as many embryos in terrestrial versus aquatic environments and that air-reared embryos had accelerated developmental rates. Surprisingly, air-reared embryos consumed 44% less oxygen and possessed larger yolk reserves, but attained the same mass, length and chorion thickness. Water-reared embryos moved their opercula ∼2.5 more times per minute compared with air-reared embryos at 7 days post-release, which probably contributed to the higher rates of oxygen uptake and yolk utilization we observed. Genetically identical air- and water-reared embryos from the same parent were raised to maturity, but the embryonic environment did not affect growth, reproduction or emersion ability in adults. Therefore, although aspects of early development were plastic, these early differences were not sustained into adulthood. Kryptolebias marmoratus embryos hatched out of water when exposed to aerial hypoxia. We conclude that exposure to a terrestrial environment reduces the energetic costs of development partly by reducing the necessity of embryonic movements to dispel stagnant boundary layers. Terrestrial incubation of young would be especially beneficial to amphibious fishes that occupy aquatic habitats of poor water quality, assuming low terrestrial predation and desiccation risks. © 2015. Published by The Company of Biologists Ltd.

  2. Terrestrial Feedbacks Incorporated in Global Vegetation Models through Observed Trait-Environment Responses

    Science.gov (United States)

    Bodegom, P. V.

    2015-12-01

    Most global vegetation models used to evaluate climate change impacts rely on plant functional types to describe vegetation responses to environmental stresses. In a traditional set-up in which vegetation characteristics are considered constant within a vegetation type, the possibility to implement and infer feedback mechanisms are limited as feedback mechanisms will likely involve a changing expression of community trait values. Based on community assembly concepts, we implemented functional trait-environment relationships into a global dynamic vegetation model to quantitatively assess this feature. For the current climate, a different global vegetation distribution was calculated with and without the inclusion of trait variation, emphasizing the importance of feedbacks -in interaction with competitive processes- for the prevailing global patterns. These trait-environmental responses do, however, not necessarily imply adaptive responses of vegetation to changing conditions and may locally lead to a faster turnover in vegetation upon climate change. Indeed, when running climate projections, simulations with trait variation did not yield a more stable or resilient vegetation than those without. Through the different feedback expressions, global and regional carbon and water fluxes were -however- strongly altered. At a global scale, model projections suggest an increased productivity and hence an increased carbon sink in the next decades to come, when including trait variation. However, by the end of the century, a reduced carbon sink is projected. This effect is due to a downregulation of photosynthesis rates, particularly in the tropical regions, even when accounting for CO2-fertilization effects. Altogether, the various global model simulations suggest the critical importance of including vegetation functional responses to changing environmental conditions to grasp terrestrial feedback mechanisms at global scales in the light of climate change.

  3. Synthesis and biological evaluation of febrifugine analogues.

    Science.gov (United States)

    Mai, Huong Doan Thi; Thanh, Giang Vo; Tran, Van Hieu; Vu, Van Nam; Vu, Van Loi; Le, Cong Vinh; Nguyen, Thuy Linh; Phi, Thi Dao; Truong, Bich Ngan; Chau, Van Minh; Pham, Van Cuong

    2014-12-01

    A series of febrifugine analogues were designed and synthesized. Antimalarial activity evaluation of the synthetic compounds indicated that these derivatives had a strong inhibition against both chloroquine-sensitive and -resistant Plasmodium falciparum parasites. Many of them were found to be more active than febrifugine hydrochloride. The tested analogues had also a significant cytotoxicity against four cancer cell lines (KB, MCF7, LU1 and HepG2). Among the synthetic analogues, two compounds 17b and 17h displayed a moderate cytotoxicity while they exhibited a remarkable antimalarial activity.

  4. Assessment of six dissimilarity metrics for climate analogues

    Science.gov (United States)

    Grenier, Patrick; Parent, Annie-Claude; Huard, David; Anctil, François; Chaumont, Diane

    2013-04-01

    Spatial analogue techniques consist in identifying locations whose recent-past climate is similar in some aspects to the future climate anticipated at a reference location. When identifying analogues, one key step is the quantification of the dissimilarity between two climates separated in time and space, which involves the choice of a metric. In this communication, spatial analogues and their usefulness are briefly discussed. Next, six metrics are presented (the standardized Euclidean distance, the Kolmogorov-Smirnov statistic, the nearest-neighbor distance, the Zech-Aslan energy statistic, the Friedman-Rafsky runs statistic and the Kullback-Leibler divergence), along with a set of criteria used for their assessment. The related case study involves the use of numerical simulations performed with the Canadian Regional Climate Model (CRCM-v4.2.3), from which three annual indicators (total precipitation, heating degree-days and cooling degree-days) are calculated over 30-year periods (1971-2000 and 2041-2070). Results indicate that the six metrics identify comparable analogue regions at a relatively large scale, but best analogues may differ substantially. For best analogues, it is also shown that the uncertainty stemming from the metric choice does generally not exceed that stemming from the simulation or model choice. A synthesis of the advantages and drawbacks of each metric is finally presented, in which the Zech-Aslan energy statistic stands out as the most recommended metric for analogue studies, whereas the Friedman-Rafsky runs statistic is the least recommended, based on this case study.

  5. Mapping the Relative Probability of Common Toad Occurrence in Terrestrial Lowland Farm Habitat in the United Kingdom.

    Directory of Open Access Journals (Sweden)

    Rosie D Salazar

    Full Text Available The common toad (Bufo bufo is of increasing conservation concern in the United Kingdom (UK due to dramatic population declines occurring in the past century. Many of these population declines coincided with reductions in both terrestrial and aquatic habitat availability and quality and have been primarily attributed to the effect of agricultural land conversion (of natural and semi-natural habitats to arable and pasture fields and pond drainage. However, there is little evidence available to link habitat availability with common toad population declines, especially when examined at a broad landscape scale. Assessing such patterns of population declines at the landscape scale, for instance, require an understanding of how this species uses terrestrial habitat.We intensively studied the terrestrial resource selection of a large population of common toads in Oxfordshire, England, UK. Adult common toads were fitted with passive integrated transponder (PIT tags to allow detection in the terrestrial environment using a portable PIT antenna once toads left the pond and before going into hibernation (April/May-October 2012 and 2013. We developed a population-level resource selection function (RSF to assess the relative probability of toad occurrence in the terrestrial environment by collecting location data for 90 recaptured toads.The predicted relative probability of toad occurrence for this population was greatest in wooded habitat near to water bodies; relative probability of occurrence declined dramatically > 50 m from these habitats. Toads also tended to select habitat near to their breeding pond and toad occurrence was negatively related to urban environments.

  6. Microplastics in the aquatic and terrestrial environment: sources (with a specific focus on personal care products), fate and effects.

    Science.gov (United States)

    Duis, Karen; Coors, Anja

    2016-01-01

    Due to the widespread use and durability of synthetic polymers, plastic debris occurs in the environment worldwide. In the present work, information on sources and fate of microplastic particles in the aquatic and terrestrial environment, and on their uptake and effects, mainly in aquatic organisms, is reviewed. Microplastics in the environment originate from a variety of sources. Quantitative information on the relevance of these sources is generally lacking, but first estimates indicate that abrasion and fragmentation of larger plastic items and materials containing synthetic polymers are likely to be most relevant. Microplastics are ingested and, mostly, excreted rapidly by numerous aquatic organisms. So far, there is no clear evidence of bioaccumulation or biomagnification. In laboratory studies, the ingestion of large amounts of microplastics mainly led to a lower food uptake and, consequently, reduced energy reserves and effects on other physiological functions. Based on the evaluated data, the lowest microplastic concentrations affecting marine organisms exposed via water are much higher than levels measured in marine water. In lugworms exposed via sediment, effects were observed at microplastic levels that were higher than those in subtidal sediments but in the same range as maximum levels in beach sediments. Hydrophobic contaminants are enriched on microplastics, but the available experimental results and modelling approaches indicate that the transfer of sorbed pollutants by microplastics is not likely to contribute significantly to bioaccumulation of these pollutants. Prior to being able to comprehensively assess possible environmental risks caused by microplastics a number of knowledge gaps need to be filled. However, in view of the persistence of microplastics in the environment, the high concentrations measured at some environmental sites and the prospective of strongly increasing concentrations, the release of plastics into the environment should be

  7. Identifying the plant-associated microbiome across aquatic and terrestrial environments: the effects of amplification method on taxa discovery

    Energy Technology Data Exchange (ETDEWEB)

    Jackrel, Sara L. [Department of Ecology and Evolution, The University of Chicago, 1101 E 57th Street Chicago IL 60637 USA; Owens, Sarah M. [Biosciences Division, Argonne National Laboratory, 9700 S. Cass Avenue Lemont IL 60439 USA; Gilbert, Jack A. [Biosciences Division, Argonne National Laboratory, 9700 S. Cass Avenue Lemont IL 60439 USA; The Microbiome Center, Department of Surgery, The University of Chicago, 5841 S Maryland Ave Chicago IL 60637 USA; Pfister, Catherine A. [Department of Ecology and Evolution, The University of Chicago, 1101 E 57th Street Chicago IL 60637 USA

    2017-01-25

    Plants in terrestrial and aquatic environments contain a diverse microbiome. Yet, the chloroplast and mitochondria organelles of the plant eukaryotic cell originate from free-living cyanobacteria and Rickettsiales. This represents a challenge for sequencing the plant microbiome with universal primers, as ~99% of 16S rRNA sequences may consist of chloroplast and mitochondrial sequences. Peptide nucleic acid clamps offer a potential solution by blocking amplification of host-associated sequences. We assessed the efficacy of chloroplast and mitochondria-blocking clamps against a range of microbial taxa from soil, freshwater and marine environments. While we found that the mitochondrial blocking clamps appear to be a robust method for assessing animal-associated microbiota, Proteobacterial 16S rRNA binds to the chloroplast-blocking clamp, resulting in a strong sequencing bias against this group. We attribute this bias to a conserved 14-bp sequence in the Proteobacteria that matches the 17-bp chloroplast-blocking clamp sequence. By scanning the Greengenes database, we provide a reference list of nearly 1500 taxa that contain this 14-bp sequence, including 48 families such as the Rhodobacteraceae, Phyllobacteriaceae, Rhizobiaceae, Kiloniellaceae and Caulobacteraceae. To determine where these taxa are found in nature, we mapped this taxa reference list against the Earth Microbiome Project database. These taxa are abundant in a variety of environments, particularly aquatic and semiaquatic freshwater and marine habitats. To facilitate informed decisions on effective use of organelle-blocking clamps, we provide a searchable database of microbial taxa in the Greengenes and Silva databases matching various n-mer oligonucleotides of each PNA sequence.

  8. Synthesis and anticancer evaluation of spermatinamine analogues

    KAUST Repository

    Moosa, Basem; Sagar, Sunil; Li, Song; Esau, Luke; Kaur, Mandeep; Khashab, Niveen M.

    2016-01-01

    analogues and their cytotoxic evaluation against three human cancer cell lines i.e. cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF-7), and prostate carcinoma (DU145). Analogues 12, 14 and 15 were found to be the most potent against one or more cell

  9. Insulin analogues in pregnancy and specific congenital anomalies

    DEFF Research Database (Denmark)

    de Jong, Josta; Garne, Ester; Wender-Ozegowska, Ewa

    2016-01-01

    Insulin analogues are commonly used in pregnant women with diabetes. It is not known if the use of insulin analogues in pregnancy is associated with any higher risk of congenital anomalies in the offspring compared with use of human insulin. We performed a literature search for studies of pregnant...... women with pregestational diabetes using insulin analogues in the first trimester and information on congenital anomalies. The studies were analysed to compare the congenital anomaly rate among foetuses of mothers using insulin analogues with foetuses of mothers using human insulin. Of 29 studies, we...... samples in the included studies provided insufficient statistical power to identify a moderate increased risk of specific congenital anomalies. Copyright © 2015 John Wiley & Sons, Ltd....

  10. Glucagon-like peptide-1 analogues: An overview

    Directory of Open Access Journals (Sweden)

    Vishal Gupta

    2013-01-01

    Full Text Available Abnormalities of the incretin axis have been implicated in the pathogenesis of type 2 diabetes mellitus. Glucagon-like peptide-1 (GLP-1 and gastroinhibitory intestinal peptide constitutes >90% of all the incretin function. Augmentation of GLP-1 results in improvement of beta cell health in a glucose-dependant manner (post-prandial hyperglycemia and suppression of glucagon (fasting hyperglycemia, amongst other beneficial pleiotropic effects. Native GLP-1 has a very short plasma half-life and novel methods have been developed to augment its half life, such that its anti-hyperglycemic effects can be exploited. They can be broadly classified as exendin-based therapies (exenatide, exenatide once weekly, DPP-4-resistant analogues (lixisenatide, albiglutide, and analogues of human GLP-1 (liraglutide, taspoglutide. Currently, commercially available analogues are exenatide, exenatide once weekly, and liraglutide. This review aims to provide an overview of most GLP-1 analogues.

  11. Analogue circuits simulation

    Energy Technology Data Exchange (ETDEWEB)

    Mendo, C

    1988-09-01

    Most analogue simulators have evolved from SPICE. The history and description of SPICE-like simulators are given. From a mathematical formulation of the electronic circuit the following analysis are possible: DC, AC, transient, noise, distortion, Worst Case and Statistical.

  12. Uncertainties and credibility building of safety analyses. Natural analogues

    International Nuclear Information System (INIS)

    Laciok, A.

    2001-07-01

    The substance of natural analogues and their studies is defined as a complementary method to laboratory and in-situ experiments and modelling. The role of natural analogues in the processes of development of repositories is defined, mainly in performance assessment of repository system and communication with public. The criteria for identification of natural analogues which should be evaluated in the phase of initiation of new studies are specified. Review part of this report is divided to study of natural analogues and study of anthropogenic and industrial analogues. The main natural analogue studies performed in various countries, in different geological setting, with various aims are characterized. New results acquired in recently finished studies are included: Palmottu (2nd phase of project financed by European Commission), Oklo (results of research financed also by European Commission), Maqarin (3rd phase) and other information obtained from last meetings and workshops of NAWG. In view of the fact that programmes of development of deep repositories in Czech and Slovak Republics are interconnected, the natural analogues studies carried out in the Czech republic are incorporated in separate chapter - study of uranium accumulation in Tertiary clays at Ruprechtov site and study of degradation of natural glasses. In final part the areas of natural analogue studies as an integral part of development of deep geological repository are proposed along with characterization of broader context and aspects of realization of these studies (international cooperation, preparation and evaluation of procedures, communication with public). (author)

  13. ACTINOMYCIN D ANALOGUES

    DEFF Research Database (Denmark)

    1997-01-01

    The present invention relates to new compounds being structurally and functionally similar to Actinomycin D and to combinatorial libraries of such compounds. The Actinomycin D analogues according to the present invention comprise two linear or cyclic peptide moieties constituted by $g...

  14. Introduction to electronic analogue computers

    CERN Document Server

    Wass, C A A

    1965-01-01

    Introduction to Electronic Analogue Computers, Second Revised Edition is based on the ideas and experience of a group of workers at the Royal Aircraft Establishment, Farnborough, Hants. This edition is almost entirely the work of Mr. K. C. Garner, of the College of Aeronautics, Cranfield. As various advances have been made in the technology involving electronic analogue computers, this book presents discussions on the said progress, including some acquaintance with the capabilities of electronic circuits and equipment. This text also provides a mathematical background including simple differen

  15. Exposure of the general public to digital broadcast transmitters compared to analogue ones

    International Nuclear Information System (INIS)

    Schubert, M.; Bornkessel, C.; Wuschek, M.; Schmidt, P.

    2007-01-01

    The terrestrial digital video and audio broadcast are supposed to replace the existing analogue broadcast systems. To determine possible changes of this switch-over on the public exposure situation to radio frequency electromagnetic fields, extensive measurements at more than 300 identical points were performed 'before' and accordingly 'after' the switch-over. At the point with the highest sum-exposure, only 0.3% of the ICNIRP reference levels for general public exposure (power flux density) was reached. The statistical analysis of both measurement campaigns ('before-after') shows an increase in mean exposure in the centre of the DVB-T starting areas around Nuremberg and Munich, which is mainly based on the increase in the radiated power at the transmitter stations. After developing a simple calculation program based on the ITU-RP.1546, the measured exposure values were compared to calculations. Optimising the results leads to mean deviations of ±3 dB at about 80% of all points. (authors)

  16. Are there pre-Quaternary geological analogues for a future greenhouse warming?

    Science.gov (United States)

    Haywood, A.M.; Ridgwell, A.; Lunt, D.J.; Hill, D.J.; Pound, M.J.; Dowsett, H.J.; Dolan, A.M.; Francis, J.E.; Williams, M.

    2011-01-01

    Given the inherent uncertainties in predicting how climate and environments will respond to anthropogenic emissions of greenhouse gases, it would be beneficial to society if science could identify geological analogues to the human race's current grand climate experiment. This has been a focus of the geological and palaeoclimate communities over the last 30 years, with many scientific papers claiming that intervals in Earth history can be used as an analogue for future climate change. Using a coupled ocean-atmosphere modelling approach, we test this assertion for the most probable pre-Quaternary candidates of the last 100 million years: the Mid- and Late Cretaceous, the Palaeocene-Eocene Thermal Maximum (PETM), the Early Eocene, as well as warm intervals within the Miocene and Pliocene epochs. These intervals fail as true direct analogues since they either represent equilibrium climate states to a long-term CO2 forcing-whereas anthropogenic emissions of greenhouse gases provide a progressive (transient) forcing on climate-or the sensitivity of the climate system itself to CO2 was different. While no close geological analogue exists, past warm intervals in Earth history provide a unique opportunity to investigate processes that operated during warm (high CO2) climate states. Palaeoclimate and environmental reconstruction/modelling are facilitating the assessment and calculation of the response of global temperatures to increasing CO2 concentrations in the longer term (multiple centuries); this is now referred to as the Earth System Sensitivity, which is critical in identifying CO2 thresholds in the atmosphere that must not be crossed to avoid dangerous levels of climate change in the long term. Palaeoclimatology also provides a unique and independent way to evaluate the qualities of climate and Earth system models used to predict future climate. ?? 2011 The Royal Society.

  17. In vitro structure-activity relationship of Re-cyclized octreotide analogues

    Energy Technology Data Exchange (ETDEWEB)

    Dannoon, Shorouk F. [Department of Chemistry, University of Missouri, Columbia, MO 65211 (United States); Bigott-Hennkens, Heather M. [Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO 65211 (United States); Ma Lixin [Department of Radiology, University of Missouri, Columbia, MO 65211 (United States); International Institute of Nano and Molecular Medicine, University of Missouri, Columbia, MO 65211 (United States); Nuclear Science and Engineering Institute, University of Missouri, Columbia, MO 65211 (United States); Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201 (United States); Gallazzi, Fabio [Structural Biology Core, University of Missouri, Columbia, MO 65211 (United States); Lewis, Michael R., E-mail: lewismic@missouri.ed [Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO 65211 (United States); Department of Radiology, University of Missouri, Columbia, MO 65211 (United States); Nuclear Science and Engineering Institute, University of Missouri, Columbia, MO 65211 (United States); Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO 65201 (United States); Jurisson, Silvia S., E-mail: jurissons@missouri.ed [Department of Chemistry, University of Missouri, Columbia, MO 65211 (United States); Department of Radiology, University of Missouri, Columbia, MO 65211 (United States); Nuclear Science and Engineering Institute, University of Missouri, Columbia, MO 65211 (United States)

    2010-07-15

    Introduction: Development of radiolabeled octreotide analogues is of interest for targeting somatostatin receptor (SSTR)-positive tumors for diagnostic and therapeutic purposes. We are investigating a direct labeling approach for incorporation of a Re ion into octreotide analogues, where the peptide sequences are cyclized via coordination to Re rather than through a disulfide bridge. Methods: Various octreotide analogue sequences and coordination systems (e.g., S{sub 2}N{sub 2} and S{sub 3}N) were synthesized and cyclized with nonradioactive Re. In vitro competitive binding assays with {sup 111}In-DOTA-Tyr{sup 3}-octreotide in AR42J rat pancreatic tumor cells yielded IC{sub 50} values as a measure of SSTR affinity of the Re-cyclized analogues. Three-dimensional structures of Re-cyclized Tyr{sup 3}-octreotate and its disulfide-bridged analogue were calculated from two-dimensional NMR experiments to visualize the effect of metal cyclization on the analogue's pharmacophore. Results: Only two of the 11 Re-cyclized analogues investigated showed moderate in vitro binding affinity toward somatostatin subtype 2 receptors. Three-dimensional molecular structures of Re- and disulfide-cyclized Tyr{sup 3}-octreotate were calculated, and both of their pharmacophore turns appear to be very similar with minor differences due to metal coordination to the amide nitrogen of one of the pharmacophore amino acids. Conclusions: Various Re-cyclized analogues were developed and analogue 4 had moderate affinity toward somatostatin subtype 2 receptors. In vitro stable studies that are in progress showed stable radiometal cyclization of octreotide analogues via NS{sub 3} and N{sub 2}S{sub 2} coordination forming five- and six-membered chelate rings. In vivo biodistribution studies are underway of {sup 99m}Tc-cyclized analogue 4.

  18. Radioisotope power sources in the terrestrial and marine environment

    International Nuclear Information System (INIS)

    Holleman, T.J.; Wahlquist, E.J.

    1976-01-01

    In response to user agency needs, the Energy Research and Development Administration (ERDA), Division of Nuclear Research and Applications (NRA), has undertaken a variety of research and development efforts to insure the availability of highly reliable, long-lived nuclear power sources for special purpose terrestrial missions planned for the late 1970's and early 1980's. One such effort currently being pursued is the development of a 1kW(e) Stirling Radioisotope Power System for integration into an Unmanned Free Swimming Submersible (UFSS) demonstration vehicle now under development by the Naval Research Laboratory. Another important effort which NRA has undertaken is a study to evaluate both isotope fueled and non-isotope fueled unattended power systems in the 2kW(e) range for application in cold regions. In the lower power ranges of Radioisotope Thermoelectric Generators, NRA continues to support new development efforts and new application areas. The Division is providing assistance to the Navy on a 1 / 2 W(e) RTG for use in various underwater applications. The various efforts are briefly discussed

  19. Northern Marshall Islands radiological survey: terrestrial food chain and total doses

    International Nuclear Information System (INIS)

    Robison, W.L.; Mount, M.E.; Phillips, W.A.; Conrado, C.A.; Stuart, M.L.; Stoker, C.E.

    1982-01-01

    A radiological survey was conducted from September through November of 1978 to assess the concentrations of persistent manmade radionuclides in the terrestrial and marine environments of 11 atolls and 2 islands in the Northern Marshall Islands. The survey consisted mainly of an aerial radiological reconnaissance to map the external gamma-ray exposure rates over the islands of each atoll. The logistical support for the entire survey was designed to accommodate this operation. As a secondary phase of the survey, shore parties collected appropriate terrestrial and marine samples to assess the radiological dose from pertinent food chains to those individuals residing on the atolls, who may in the future reside on some of the presently uninhabited atolls, or who collect food from these atolls. Over 5000 terrestrial and marine samples were collected for radionuclide analysis from 76 different islands. Soils, vegetation, indigenous animals, and cistern water and groundwater were collected from the islands. Reef and pelagic fish, clams, lagoon water, and sediments were obtained from the lagoons. The concentration data for 90 Sr, 137 Cs, 238 Pu, 239 240 Pu, and 241 Am in terrestrial food crops, fowl, and animals collected at the atolls or islands are summarized. An assessment of the total dose from the major exposure pathways including external gamma, terrestrial food chain including food products and drinking water, marine food chain, and inhalation is provided. Radiological doses at each atoll or island are calculated from the average radionuclide concentrations in the terrestrial foods, marine foods, etc. assuming the average daily intake for each food item

  20. Terrestrial invasion of pomatiopsid gastropods in the heavy-snow region of the Japanese Archipelago

    Directory of Open Access Journals (Sweden)

    Kato Makoto

    2011-05-01

    Full Text Available Abstract Background Gastropod mollusks are one of the most successful animals that have diversified in the fully terrestrial habitat. They have evolved terrestrial taxa in more than nine lineages, most of which originated during the Paleozoic or Mesozoic. The rissooidean gastropod family Pomatiopsidae is one of the few groups that have evolved fully terrestrial taxa during the late Cenozoic. The pomatiopsine diversity is particularly high in the Japanese Archipelago and the terrestrial taxa occur only in this region. In this study, we conducted thorough samplings of Japanese pomatiopsid species and performed molecular phylogenetic analyses to explore the patterns of diversification and terrestrial invasion. Results Molecular phylogenetic analyses revealed that Japanese Pomatiopsinae derived from multiple colonization of the Eurasian Continent and that subsequent habitat shifts from aquatic to terrestrial life occurred at least twice within two Japanese endemic lineages. Each lineage comprises amphibious and terrestrial species, both of which are confined to the mountains in heavy-snow regions facing the Japan Sea. The estimated divergence time suggested that diversification of these terrestrial lineages started in the Late Miocene, when active orogenesis of the Japanese landmass and establishment of snowy conditions began. Conclusions The terrestrial invasion of Japanese Pomatiopsinae occurred at least twice beside the mountain streamlets of heavy-snow regions, which is considered the first case of this event in the area. Because snow coverage maintains stable temperatures and high humidity on the ground surface, heavy-snow conditions may have paved the way for these organisms from freshwater to land via mountain streamlets by preventing winter desiccation in mountain valleys. The fact that the terrestrialization of Pomatiopsidae occurred only in year-round wet environments, but not in seasonally dried regions, provides new insight into ancient

  1. Validation of models for the transfer of radionuclides in terrestrial, urban and aquatic environments and acquisition of data for that purpose

    International Nuclear Information System (INIS)

    Linsley, G.S.; Koehler, H.; Calmet, D.

    1990-01-01

    The radioactive fallout from the Chernobyl accident has offered the opportunity to test the predictions of dose assessment models using measurements made under real conditions. A joint co-ordinated research programme of the International Atomic Energy Agency and the Commission of the European Communities seeks to take advantage of the 'natural laboratory' created as a result of the Chernobyl release. Three working groups have been established concerned with model validation for the terrestrial, urban and freshwater aquatic environments; in addition a fourth group, the Multiple Pathway Assessment Working Group, will seek to validate models for estimating overall transfer from the atmosphere and ground deposits to human intake. The paper outlines the plans for the study, which started in 1988 and will continue until 1992. (author). 2 refs

  2. Acclimation of a terrestrial plant to submergence facilitates gas exchange under water

    DEFF Research Database (Denmark)

    Mommer, L.; Pedersen, O.; Visser, E. J. W.

    2004-01-01

    Flooding imposes stress upon terrestrial plants since it severely hampers gas exchange rates between the shoot and the environment. The resulting oxygen deficiency is considered to be the major problem for submerged plants. Oxygen microelectrode studies have, however, shown that aquatic plants...... of this terrestrial plant species to submergence for gas exchange capacity is also shown. Shoot acclimation to submergence involved a reduction of the diffusion resistance to gases, which was not only functional by increasing diffusion of oxygen into the plant, but also by increasing influx of CO2, which enhances...... maintain relatively high internal oxygen pressures under water, and even may release oxygen via the roots into the sediment, also in dark. Based on these results, we challenge the dogma that oxygen pressures in submerged terrestrial plants immediately drop to levels at which aerobic respiration is impaired...

  3. Vanadium Chloroperoxidases: The Missing Link in the Formation of Chlorinated Compounds and Chloroform in the Terrestrial Environment?

    Science.gov (United States)

    Wever, Ron; Barnett, Phil

    2017-08-17

    It is well established that the majority of chlorinated organic substances found in the terrestrial environment are produced naturally. The presence of these compounds in soils is not limited to a single ecosystem. Natural chlorination is also a widespread phenomenon in grasslands and agricultural soils typical for unforested areas. These chlorinated compounds are formed from chlorination of natural organic matter consisting of very complex chemical structures, such as lignin. Chlorination of several lignin model compounds results in the intermediate formation of trichloroacetyl-containing compounds, which are also found in soils. These decay, in general, through a haloform-type reaction mechanism to CHCl 3 . Upon release into the atmosphere, CHCl 3 will produce chlorine radicals through photolysis, which will, in turn, lead to natural depletion of ozone. There is evidence that fungal chloroperoxidases able to produce HOCl are involved in the chlorination of natural organic matter. The objective of this review is to clarify the role and source of the various chloroperoxidases involved in the natural formation of CHCl 3 . © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Pressurized brines in continental Antarctica as a possible analogue of Mars

    OpenAIRE

    Forte, Emanuele; Dalle Fratte, Michele; Azzaro, Maurizio; Guglielmin, Mauro

    2016-01-01

    Interest in brines in extreme and cold environments has recently increased after they have been found on Mars. Those brines can be potential new subsurface habitats for peculiar ecosystems. In the McMurdo Dry Valleys of the Antarctic, the best analogue for Mars conditions, only a few cases of brines have been identified in some perennially frozen lakes and in one case in an underground aquifer. Here, we present the occurrence of pressurized brines in a shallow perennially ice-covered lake sou...

  5. Causal structure of analogue spacetimes

    International Nuclear Information System (INIS)

    Barcelo, Carlos; Liberati, Stefano; Sonego, Sebastiano; Visser, Matt

    2004-01-01

    The so-called 'analogue models of general relativity' provide a number of specific physical systems, well outside the traditional realm of general relativity, that nevertheless are well-described by the differential geometry of curved spacetime. Specifically, the propagation of perturbations in these condensed matter systems is described by 'effective metrics' that carry with them notions of 'causal structure' as determined by an exchange of quasi-particles. These quasi-particle-induced causal structures serve as specific examples of what can be done in the presence of a Lorentzian metric without having recourse to the Einstein equations of general relativity. (After all, the underlying analogue model is governed by its own specific physics, not necessarily by the Einstein equations.) In this paper we take a careful look at what can be said about the causal structure of analogue spacetimes, focusing on those containing quasi-particle horizons, both with a view to seeing what is different from standard general relativity, and what the similarities might be. For definiteness, and because the physics is particularly simple to understand, we will phrase much of the discussion in terms of acoustic disturbances in moving fluids, where the underlying physics is ordinary fluid mechanics, governed by the equations of traditional hydrodynamics, and the relevant quasi-particles are the phonons. It must however be emphasized that this choice of example is only for the sake of pedagogical simplicity and that our considerations apply generically to wide classes of analogue spacetimes

  6. Natural analogues and radionuclide transport model validation

    International Nuclear Information System (INIS)

    Lever, D.A.

    1987-08-01

    In this paper, some possible roles for natural analogues are discussed from the point of view of those involved with the development of mathematical models for radionuclide transport and with the use of these models in repository safety assessments. The characteristic features of a safety assessment are outlined in order to address the questions of where natural analogues can be used to improve our understanding of the processes involved and where they can assist in validating the models that are used. Natural analogues have the potential to provide useful information about some critical processes, especially long-term chemical processes and migration rates. There is likely to be considerable uncertainty and ambiguity associated with the interpretation of natural analogues, and thus it is their general features which should be emphasized, and models with appropriate levels of sophistication should be used. Experience gained in modelling the Koongarra uranium deposit in northern Australia is drawn upon. (author)

  7. The terrestrial biosphere in the SFR region

    Energy Technology Data Exchange (ETDEWEB)

    Jerling, L; Isaeus, M [Stockholm Univ. (Sweden). Dept. of Botany; Lanneck, J [Stockholm Univ. (Sweden). Dept. of Physical Geography; Lindborg, T; Schueldt, R [Danish Nature Council, Copenhagen (Denmark)

    2001-03-01

    This report is a part of the SKB project 'SAFE' (Safety Assessment of the Final Repository of Radioactive Operational Waste). The aim of project SAFE is to update the previous safety analysis of SFR-1.SFR-1 is a facility for disposal of low and intermediate level radioactive waste, which is situated in bedrock beneath the Baltic Sea, one km off the coast near the Forsmark nuclear power plant in Northern Uppland. A part of the SAFE-analysis aims at analysing the transport of radionuclides in the ecosystems.To do so one has to build a model that includes a large amount of information concerning the biosphere.The first step is to collect and compile descriptions of the biosphere.This report is a first attempt to characterise the terrestrial environment of the SFR area of Forsmark. In the first part of the report the terrestrial environment, land class distribution and production of the area is described. The primary production in different terrestrial ecosystems is estimated for a model area in the Forsmark region. The estimations are based on the actual land class distribution and the values for the total primary production (d.w. above ground biomass)and the amount carbon produced, presented as g/m{sup 2} for each land class respectively. An important aspect of the biosphere is the vegetation and its development. The future development of vegetation is of interest since production,decomposition and thus storage of organic material, vary strongly among vegetation types and this has strong implications for the transport of radionuclides.Therefore an attempt to describe the development of terrestrial vegetation has been made in the second part. Any prediction of future vegetation is based on knowledge of the past together with premises for the future development.The predictions made, thus, becomes marred with errors enforced by the assumptions and incomplete information of the past. The assumptions made for the predictions in this report are crude and results in a

  8. The terrestrial biosphere in the SFR region

    International Nuclear Information System (INIS)

    Jerling, L.; Isaeus, M.

    2001-03-01

    This report is a part of the SKB project 'SAFE' (Safety Assessment of the Final Repository of Radioactive Operational Waste). The aim of project SAFE is to update the previous safety analysis of SFR-1.SFR-1 is a facility for disposal of low and intermediate level radioactive waste, which is situated in bedrock beneath the Baltic Sea, one km off the coast near the Forsmark nuclear power plant in Northern Uppland. A part of the SAFE-analysis aims at analysing the transport of radionuclides in the ecosystems.To do so one has to build a model that includes a large amount of information concerning the biosphere.The first step is to collect and compile descriptions of the biosphere.This report is a first attempt to characterise the terrestrial environment of the SFR area of Forsmark. In the first part of the report the terrestrial environment, land class distribution and production of the area is described. The primary production in different terrestrial ecosystems is estimated for a model area in the Forsmark region. The estimations are based on the actual land class distribution and the values for the total primary production (d.w. above ground biomass)and the amount carbon produced, presented as g/m 2 for each land class respectively. An important aspect of the biosphere is the vegetation and its development. The future development of vegetation is of interest since production,decomposition and thus storage of organic material, vary strongly among vegetation types and this has strong implications for the transport of radionuclides.Therefore an attempt to describe the development of terrestrial vegetation has been made in the second part. Any prediction of future vegetation is based on knowledge of the past together with premises for the future development.The predictions made, thus, becomes marred with errors enforced by the assumptions and incomplete information of the past. The assumptions made for the predictions in this report are crude and results in a coarse

  9. The terrestrial biosphere in the SFR region

    Energy Technology Data Exchange (ETDEWEB)

    Jerling, L.; Isaeus, M. [Stockholm Univ. (Sweden). Dept. of Botany; Lanneck, J. [Stockholm Univ. (Sweden). Dept. of Physical Geography; Lindborg, T.; Schueldt, R. [Danish Nature Council, Copenhagen (Denmark)

    2001-03-01

    This report is a part of the SKB project 'SAFE' (Safety Assessment of the Final Repository of Radioactive Operational Waste). The aim of project SAFE is to update the previous safety analysis of SFR-1.SFR-1 is a facility for disposal of low and intermediate level radioactive waste, which is situated in bedrock beneath the Baltic Sea, one km off the coast near the Forsmark nuclear power plant in Northern Uppland. A part of the SAFE-analysis aims at analysing the transport of radionuclides in the ecosystems.To do so one has to build a model that includes a large amount of information concerning the biosphere.The first step is to collect and compile descriptions of the biosphere.This report is a first attempt to characterise the terrestrial environment of the SFR area of Forsmark. In the first part of the report the terrestrial environment, land class distribution and production of the area is described. The primary production in different terrestrial ecosystems is estimated for a model area in the Forsmark region. The estimations are based on the actual land class distribution and the values for the total primary production (d.w. above ground biomass)and the amount carbon produced, presented as g/m{sup 2} for each land class respectively. An important aspect of the biosphere is the vegetation and its development. The future development of vegetation is of interest since production,decomposition and thus storage of organic material, vary strongly among vegetation types and this has strong implications for the transport of radionuclides.Therefore an attempt to describe the development of terrestrial vegetation has been made in the second part. Any prediction of future vegetation is based on knowledge of the past together with premises for the future development.The predictions made, thus, becomes marred with errors enforced by the assumptions and incomplete information of the past. The assumptions made for the predictions in this report are crude and results

  10. Acclimation of a terrestrial plant to submergence facilitates gas exchange under water

    NARCIS (Netherlands)

    Mommer, L.; Pedersen, O.; Visser, E.J.W.

    2004-01-01

    Flooding imposes stress upon terrestrial plants since it severely hampers gas exchange rates between the shoot and the environment. The resulting oxygen deficiency is considered to be the major problem for submerged plants. Oxygen microelectrode studies have, however, shown that aquatic plants

  11. The Palmottu analogue project

    International Nuclear Information System (INIS)

    Ahonen, L.; Blomqvist, R.; Suksi, J.

    1993-01-01

    The report gives a summary of the results of investigations carried out in 1992 at the Palmottu natural analogue study site, which is a small U-Th mineralization in Nummi-Pusula, southwestern Finland. Additionally, the report includes several separate articles dealing with various aspects of the Palmottu Analogue Project: (1) deep groundwater flow, (2) interpretation of hydraulic connections, (3) characterization of groundwater colloids, (4) uranium mineral-groundwater equilibrium, (5) water-rock interaction and (6) modelling of in situ matrix diffusion. The Palmottu Analogue Project aims at a more profound understanding of radionuclide transport processes in fractured crystalline bedrock. The essential factors controlling transport are groundwater flow and interaction between water and rock. Accordingly, the study includes (1) structural interpretations partly based on geophysical measurements, (2) hydrological studies including hydraulic drill-hole measurements, (3) flow modelling, (4) hydrogeochemical characterization of groundwater, uranium chemistry and colloid chemistry, (5) mineralogical studies, (6) geochemical interpretation and modelling, (7) studies of radionuclide mobilization and retardation including matrix diffusion, and (8) modelling of uranium series data. Palaeohydrogeological aspects, due to the anticipated future glaciation of the Fennoscandian Shield, are of special interest. Quaternary sediments are studied to gain information on post-glacial migration in the overburden. (orig.)

  12. V. Terrestrial vertebrates

    Science.gov (United States)

    Dean Pearson; Deborah Finch

    2011-01-01

    Within the Interior West, terrestrial vertebrates do not represent a large number of invasive species relative to invasive weeds, aquatic vertebrates, and invertebrates. However, several invasive terrestrial vertebrate species do cause substantial economic and ecological damage in the U.S. and in this region (Pimental 2000, 2007; Bergman and others 2002; Finch and...

  13. The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.

    Directory of Open Access Journals (Sweden)

    Bryan L Roth

    Full Text Available In this paper we determined the pharmacological profiles of novel ketamine and phencyclidine analogues currently used as 'designer drugs' and compared them to the parent substances via the resources of the National Institute of Mental Health Psychoactive Drug Screening Program. The ketamine analogues methoxetamine ((RS-2-(ethylamino-2-(3-methoxyphenylcyclohexanone and 3-MeO-PCE (N-ethyl-1-(3-methoxyphenylcyclohexanamine and the 3- and 4-methoxy analogues of phencyclidine, (1-[1-(3-methoxyphenylcyclohexyl]piperidine and 1-[1-(4-methoxyphenylcyclohexyl]piperidine, were all high affinity ligands for the PCP-site on the glutamate NMDA receptor. In addition methoxetamine and PCP and its analogues displayed appreciable affinities for the serotonin transporter, whilst the PCP analogues exhibited high affinities for sigma receptors. Antagonism of the NMDA receptor is thought to be the key pharmacological feature underlying the actions of dissociative anaesthetics. The novel ketamine and PCP analogues had significant affinities for the NMDA receptor in radioligand binding assays, which may explain their psychotomimetic effects in human users. Additional actions on other targets could be important for delineating side-effects.

  14. Natural analogues to the conditions around a final repository for high-level radioactive waste

    International Nuclear Information System (INIS)

    Smellie, J.A.T.

    1984-12-01

    This report documents the proceedings resulting from a Workshop held at Lake Geneva, Wisconsin, USA, from 1-3 October, 1984. The theme of the Workshop was entitled 'Natural analogues to the conditions around a final repository for high-level radioactive waste', and was restricted to ultimate disposal in a crystalline bedrock environment. The Workshop provided an important first step in co-ordinating and focussing different national and individual interests and approaches towards natural analogue studies. One of the points highlighted at the concluding forum of the meeting was the necessity to first define the geochemical processes which are assumed to occur after disposal of the radioactive waste, and then locate suitable analogue systems which can be used to test the mechanisms of one, or a simple combination of these geochemical processes. Even accepting that the choice of which geochemical process(es) to be selected for validation will be sensitive to individual national disposal strategies, farfield radionuclide retardation mechanisms in the geosphere were considered to be a central topic of importance, and should therefore be given high priority. At this early stage in the development of natural analogue studies it was not possible to cover all the important aspects. In retrospect, the role of the models should have received more attention; bridging the gap between geoscientists and the modellers was seen as being of prime importance in future meetings of this nature. (author)

  15. The Mojave vadose zone: a subsurface biosphere analogue for Mars.

    Science.gov (United States)

    Abbey, William; Salas, Everett; Bhartia, Rohit; Beegle, Luther W

    2013-07-01

    If life ever evolved on the surface of Mars, it is unlikely that it would still survive there today, but as Mars evolved from a wet planet to an arid one, the subsurface environment may have presented a refuge from increasingly hostile surface conditions. Since the last glacial maximum, the Mojave Desert has experienced a similar shift from a wet to a dry environment, giving us the opportunity to study here on Earth how subsurface ecosystems in an arid environment adapt to increasingly barren surface conditions. In this paper, we advocate studying the vadose zone ecosystem of the Mojave Desert as an analogue for possible subsurface biospheres on Mars. We also describe several examples of Mars-like terrain found in the Mojave region and discuss ecological insights that might be gained by a thorough examination of the vadose zone in these specific terrains. Examples described include distributary fans (deltas, alluvial fans, etc.), paleosols overlain by basaltic lava flows, and evaporite deposits.

  16. Application of natural analogues in the Yucca Mountain project - overview

    International Nuclear Information System (INIS)

    Simmons, Ardyth M.

    2003-01-01

    The Natural Analogue Synthesis Report (NASR) [1] provides a compilation of information from analogues that test, corroborate, and add confidence to process models and model predictions pertinent to total system performance assessment (TSPA). The report updated previous work [2] with new literature examples and results of quantitative studies conducted by the Yucca Mountain Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate greater understanding of processes expected to occur during postclosure of a proposed Yucca Mountain repository. Natural analogues, as used here, refer to either natural or anthropogenic systems in which processes similar to those expected to occur in a nuclear waste repository are thought to have occurred over long time periods (decades to millenia) and large spatial scales (up to tens of kilometers). In the past, the YMP has used analogues for testing and building confidence in conceptual and numerical process models in a number of ways. Yucca Mountain mineral alteration phases provided a self-analogue for postclosure alteration [3]. Thermodynamic parameters for silica minerals of the Wairakai, New Zealand geothermal field were added to databases used in geochemical modeling [4]. Scoping calculations of radionuclide transport using the Yucca Mountain TSPA numerical model were conducted for the Peqa Blanca site [5]. Eruption parameters from the Cerro Negro volcano, Nicaragua, were used to verify codes that model ash plume dispersion [6]. Analogues have also been used in supplemental science and performance analyses to provide multiple lines of evidence in support of both analyses and model reports (AMRs) [7]; in screening arguments for inclusion or exclusion of features, events, and processes (FEP)s in TSPAs; in the quantification of uncertainties [7]; in expert elicitations of volcanic and seismic hazards [8, 9] and in peer reviews [10]. Natural analogues may be applied

  17. Synthesis and anticancer evaluation of spermatinamine analogues

    KAUST Repository

    Moosa, Basem

    2016-02-04

    Spermatinamine was isolated from an Australian marine sponge, Pseudoceratina sp. as an inhibitor of isoprenylcystiene carboxyl methyltransferase (Icmt), an attractive and novel anticancer target. Herein, we report the synthesis of spermatinamine analogues and their cytotoxic evaluation against three human cancer cell lines i.e. cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF-7), and prostate carcinoma (DU145). Analogues 12, 14 and 15 were found to be the most potent against one or more cell lines with the IC50 values in the range of 5 - 10 μM. The obtained results suggested that longer polyamine linker along with aromatic oxime substitution provided the most potent analogue compounds against cancer cell lines.

  18. Sensitive life detection strategies for low-biomass environments: optimizing extraction of nucleic acids adsorbing to terrestrial and Mars analogue minerals.

    Science.gov (United States)

    Direito, Susana O L; Marees, Andries; Röling, Wilfred F M

    2012-07-01

    The adsorption of nucleic acids to mineral matrixes can result in low extraction yields and negatively influences molecular microbial ecology studies, in particular for low-biomass environments on Earth and Mars. We determined the recovery of nucleic acids from a range of minerals relevant to Earth and Mars. Clay minerals, but also other silicates and nonsilicates, showed very low recovery (< 1%). Consequently, optimization of DNA extraction was directed towards clays. The high temperatures and acidic conditions used in some methods to dissolve mineral matrices proved to destruct DNA. The most efficient method comprised a high phosphate solution (P/EtOH; 1 M phosphate, 15% ethanol buffer at pH 8) introduced at the cell-lysing step in DNA extraction, to promote chemical competition with DNA for adsorption sites. This solution increased DNA yield from clay samples spiked with known quantities of cells up to nearly 100-fold. DNA recovery was also enhanced from several mineral samples retrieved from an aquifer, while maintaining reproducible DGGE profiles. DGGE profiles were obtained for a clay sample for which no profile could be generated with the standard DNA isolation protocol. Mineralogy influenced microbial community composition. The method also proved suitable for the recovery of low molecular weight DNA (< 1.5 kb). © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  19. Conformationally restrained aromatic analogues of fosmidomycin and FR900098.

    Science.gov (United States)

    Kurz, Thomas; Schlüter, Katrin; Pein, Miriam; Behrendt, Christoph; Bergmann, Bärbel; Walter, Rolf D

    2007-07-01

    The synthesis and in-vitro antimalarial activity of conformationally restrained bis(pivaloyloxymethyl) ester analogues of the natural product fosmidomycin is presented. In contrast to alpha-aryl-substituted analogues, conformationally restrained aromatic analogues exhibit only moderate in-vitro antimalarial activity against the chloroquine-sensitive strain 3D7 of Plasmodium falciparum. The most active derivative displays an IC(50) value of 47 microM.

  20. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: South Florida: T_MAMMAL (Terrestrial Mammal Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for State and Federally threatened and endangered terrestrial mammals in [for] South Florida. Vector...

  1. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Central California: T_MAMMAL (Terrestrial Mammal Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for rare/sensitive species occurrences of terrestrial mammals in Central California. Vector polygons in...

  2. Downscaling of surface moisture flux and precipitation in the Ebro Valley (Spain using analogues and analogues followed by random forests and multiple linear regression

    Directory of Open Access Journals (Sweden)

    G. Ibarra-Berastegi

    2011-06-01

    Full Text Available In this paper, reanalysis fields from the ECMWF have been statistically downscaled to predict from large-scale atmospheric fields, surface moisture flux and daily precipitation at two observatories (Zaragoza and Tortosa, Ebro Valley, Spain during the 1961–2001 period. Three types of downscaling models have been built: (i analogues, (ii analogues followed by random forests and (iii analogues followed by multiple linear regression. The inputs consist of data (predictor fields taken from the ERA-40 reanalysis. The predicted fields are precipitation and surface moisture flux as measured at the two observatories. With the aim to reduce the dimensionality of the problem, the ERA-40 fields have been decomposed using empirical orthogonal functions. Available daily data has been divided into two parts: a training period used to find a group of about 300 analogues to build the downscaling model (1961–1996 and a test period (1997–2001, where models' performance has been assessed using independent data. In the case of surface moisture flux, the models based on analogues followed by random forests do not clearly outperform those built on analogues plus multiple linear regression, while simple averages calculated from the nearest analogues found in the training period, yielded only slightly worse results. In the case of precipitation, the three types of model performed equally. These results suggest that most of the models' downscaling capabilities can be attributed to the analogues-calculation stage.

  3. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Southern California: T_MAMMAL (Terrestrial Mammal Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for rare and threatened/endangered terrestrial mammals in Southern California. Vector polygons in this data...

  4. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Hudson River: T_MAMMAL (Terrestrial Mammal Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for small terrestrial mammals (woodrats, myotis, muskrat, mink) for the Hudson River. Vector polygons in...

  5. U.S. Nuclear Regulatory Commission natural analogue research program

    International Nuclear Information System (INIS)

    Kovach, L.A.; Ott, W.R.

    1995-01-01

    This article describes the natural analogue research program of the U.S. Nuclear Regulatory Commission (US NRC). It contains information on the regulatory context and organizational structure of the high-level radioactive waste research program plan. It also includes information on the conditions and processes constraining selection of natural analogues, describes initiatives of the US NRC, and describes the role of analogues in the licensing process

  6. Insulin analogues and cancer: a note of caution

    Directory of Open Access Journals (Sweden)

    Joseph A.M.J.L. eJanssen

    2014-05-01

    Full Text Available Abstract In view of the lifelong exposure and large patient populations involved, insulin analogues with an increased mitogenic effect in comparison to human insulin may potentially constitute a major health problem, since these analogues may possibly induce the growth of pre-existing neoplasms. At present, the available data suggest that insulin analogues are safe. In line with these findings, we observed that serum of diabetic patients treated with insulin analogues, compared to that of diabetic patients treated with human insulin, did not induce an increased phosphorylation of tyrosine residues of the insulin-like growth factor-I receptor (IGF-IR. However, the classical model of the IGF-IR signaling may be insufficient to explain (all mitogenic effects of insulin analogues since also non-canonical signaling pathways of the IGF-IR may play a major role in this respect. Although phosphorylation of tyrosine residues of the IGF-IR is generally considered to be the initial activation step within the intracellular IGF-IR signaling pathway, it has been found that cells undergo a signaling switch under hyperglycemic conditions. After this switch, a completely different mechanism is utilized to activate the mitogenic (mitogen-activated protein kinase (MAPK pathways of the IGF-IR that is independent from tyrosine phosphorylation of the IGF-IR. At present it is unknown whether activation of this alternative intracellular pathway of the IGF-IR occurs during hyperglycemia in vivo and whether it is stronger in patients treated with (some insulin analogues than in patients treated with human insulin. In addition, it is unknown whether the insulin receptors (IRs also undergo a signaling switch during hyperglycemia. This should be investigated in future studies. Finally, relative overexpression of IR isoform A (IR-A in (pre cancer tissues may play a key role in the development and progression of human cancers during treatment with insulin (analogues. Further

  7. Characterisation of insulin analogues therapeutically available to patients

    KAUST Repository

    Adams, Gary G.

    2018-03-29

    The structure and function of clinical dosage insulin and its analogues were assessed. This included \\'native insulins\\' (human recombinant, bovine, porcine), \\'fast-acting analogues\\' (aspart, glulisine, lispro) and \\'slow-acting analogues\\' (glargine, detemir, degludec). Analytical ultracentrifugation, both sedimentation velocity and equilibrium experiments, were employed to yield distributions of both molar mass and sedimentation coefficient of all nine insulins. Size exclusion chromatography, coupled to multi-angle light scattering, was also used to explore the function of these analogues. On ultracentrifugation analysis, the insulins under investigation were found to be in numerous conformational states, however the majority of insulins were present in a primarily hexameric conformation. This was true for all native insulins and two fast-acting analogues. However, glargine was present as a dimer, detemir was a multi-hexameric system, degludec was a dodecamer (di-hexamer) and glulisine was present as a dimer-hexamer-dihexamer system. However, size-exclusion chromatography showed that the two hexameric fast-acting analogues (aspart and lispro) dissociated into monomers and dimers due to the lack of zinc in the mobile phase. This comprehensive study is the first time all nine insulins have been characterised in this way, the first time that insulin detemir have been studied using analytical ultracentrifugation and the first time that insulins aspart and glulisine have been studied using sedimentation equilibrium. The structure and function of these clinically administered insulins is of critical importance and this research adds novel data to an otherwise complex functional physiological protein.

  8. Fungal growth inhibitory properties of new phytosphingolipid analogues.

    Science.gov (United States)

    Mormeneo, D; Manresa, A; Casas, J; Llebaria, A; Delgado, A

    2008-04-01

    To study the growth inhibitory properties of a series of phytosphingosine (PHS) and phytoceramide (PHC) analogues. A panel of two yeast (Candida albicans and Saccharomyces cerevisiae) and six moulds (Aspergillus repens, Aspergillus niger, Penicillium chrysogenum, Cladosporium cladosporioides, Arthroderma uncinatum and Penicillium funiculosum) has been used in this study. A series of new PHS and PHC analogues differing at the sphingoid backbone and the functional group at C1 position were synthesized. Among PHS analogues, 1-azido derivative 1c, bearing the natural D-ribo stereochemistry, showed a promising growth inhibitory profile. Among PHC analogues, compound 12, with a bulky N-pivaloyl group and a Z double bond at C3 position of the sphingoid chain, was the most active growth inhibitor. Minimal inhibitory concentration values were in the range of 23-48 micromol l(-1) for 1c and 44-87 micromol l(-1) for 12. Only scattered data on the antifungal activity of phytosphingolipids have been reported in the literature. This is the first time that a series of analogues of this kind are tested and compared to discern their structural requirements for antifungal activity.

  9. Exotic and invasive terrestrial and freshwater animal species in the Dutch Caribbean

    NARCIS (Netherlands)

    Buurt, van G.; Debrot, A.O.

    2011-01-01

    An overview of 72 invasive animals of the terrestrial and freshwater environments of the Dutch Caribbean, eleven of which are no longer present. All invasive animals that are principally agricultural pests and or animal and plant diseases (46 species) are excluded as these are discussed separately

  10. CO2 Capture with Enzyme Synthetic Analogue

    Energy Technology Data Exchange (ETDEWEB)

    Cordatos, Harry

    2010-11-08

    Overview of an ongoing, 2 year research project partially funded by APRA-E to create a novel, synthetic analogue of carbonic anhydrase and incorporate it into a membrane for removal of CO2 from flue gas in coal power plants. Mechanism background, preliminary feasibility study results, molecular modeling of analogue-CO2 interaction, and program timeline are provided.

  11. The Greenland Analogue Project. Yearly Report 2009

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-15

    A deep geological repository for spent nuclear fuel needs to be designed to keep used nuclear fuel isolated from mankind and the environment for a million years. Within this time frame glacial conditions are expected in regions that have been glaciated in the past two to ten million years. Climate induced changes such as the growth of ice sheets and permafrost will influence and alter the ground surface and subsurface environment, including its hydrology, which may impact repository safety. Glaciation impact assessments have to-date used over-simplified models and conservative assumptions, for example in the representation of ice sheet hydrology, that do not reflect the complexity of natural systems and processes. This is largely due to lack of direct observations of such processes from existing ice sheets, which if more readily available could help reduce uncertainties and provide a strong scientific basis for the treatment of glacial impacts in safety assessments. Our current understanding of the hydrological, hydrogeological and hydrogeochemical processes associated with glacial cycles and their impact on the long-term performance of deep geological repositories for spent nuclear fuel will be significantly improved by studying a modern analogue. To advance the understanding of processes associated with glaciation and their impact on the long-term performance of a deep geological repository, the Greenland Analogue Project (GAP), a four-year field and modelling study of the Greenland ice sheet and sub-surface conditions, has been initiated collaboratively by SKB, Posiva and NWMO. The study site encompasses a land terminus portion of the Greenland ice sheet east of Kangerlussuaq and is in many ways considered to be an appropriate analogue of the conditions that are expected to prevail in much of Canada and Fennoscandia during future glacial cycles. The project is planned to run from 2009 until 2012. The GAP will conduct the first in situ investigations of some of

  12. The Greenland Analogue Project. Yearly Report 2009

    International Nuclear Information System (INIS)

    2010-12-01

    A deep geological repository for spent nuclear fuel needs to be designed to keep used nuclear fuel isolated from mankind and the environment for a million years. Within this time frame glacial conditions are expected in regions that have been glaciated in the past two to ten million years. Climate induced changes such as the growth of ice sheets and permafrost will influence and alter the ground surface and subsurface environment, including its hydrology, which may impact repository safety. Glaciation impact assessments have to-date used over-simplified models and conservative assumptions, for example in the representation of ice sheet hydrology, that do not reflect the complexity of natural systems and processes. This is largely due to lack of direct observations of such processes from existing ice sheets, which if more readily available could help reduce uncertainties and provide a strong scientific basis for the treatment of glacial impacts in safety assessments. Our current understanding of the hydrological, hydrogeological and hydrogeochemical processes associated with glacial cycles and their impact on the long-term performance of deep geological repositories for spent nuclear fuel will be significantly improved by studying a modern analogue. To advance the understanding of processes associated with glaciation and their impact on the long-term performance of a deep geological repository, the Greenland Analogue Project (GAP), a four-year field and modelling study of the Greenland ice sheet and sub-surface conditions, has been initiated collaboratively by SKB, Posiva and NWMO. The study site encompasses a land terminus portion of the Greenland ice sheet east of Kangerlussuaq and is in many ways considered to be an appropriate analogue of the conditions that are expected to prevail in much of Canada and Fennoscandia during future glacial cycles. The project is planned to run from 2009 until 2012. The GAP will conduct the first in situ investigations of some of

  13. Insulin analogues with improved absorption characteristics.

    Science.gov (United States)

    Brange, J; Hansen, J F; Langkjaer, L; Markussen, J; Ribel, U; Sørensen, A R

    1992-01-01

    The insulin preparations available today are not ideal for therapy as s.c. injection does not provide a physiological insulin profile. With the aim to improve the absorption properties recombinant DNA technology has been utilized to design novel insulin molecules with changed physico-chemical characteristics and hence altered subcutaneous absorption kinetics. Soluble, long-acting human insulin analogues in which the isoelectric point has been increased from 5.4 to approx. 7 are absorbed very slowly, providing a more constant basal insulin delivery with lower day-to-day variation than present protracted preparations. In addition they have better storage stability. Rapid-acting human insulin analogues with largely reduced self-association are absorbed substantially faster from subcutaneous tissue than current regular insulin and thus are better suited for bolus injection. The absorption kinetics of these analogues have been able to explain the mechanism behind the dose effect on insulin absorption rate.

  14. Performance Analysis and Scaling Behavior of the Terrestrial Systems Modeling Platform TerrSysMP in Large-Scale Supercomputing Environments

    Science.gov (United States)

    Kollet, S. J.; Goergen, K.; Gasper, F.; Shresta, P.; Sulis, M.; Rihani, J.; Simmer, C.; Vereecken, H.

    2013-12-01

    In studies of the terrestrial hydrologic, energy and biogeochemical cycles, integrated multi-physics simulation platforms take a central role in characterizing non-linear interactions, variances and uncertainties of system states and fluxes in reciprocity with observations. Recently developed integrated simulation platforms attempt to honor the complexity of the terrestrial system across multiple time and space scales from the deeper subsurface including groundwater dynamics into the atmosphere. Technically, this requires the coupling of atmospheric, land surface, and subsurface-surface flow models in supercomputing environments, while ensuring a high-degree of efficiency in the utilization of e.g., standard Linux clusters and massively parallel resources. A systematic performance analysis including profiling and tracing in such an application is crucial in the understanding of the runtime behavior, to identify optimum model settings, and is an efficient way to distinguish potential parallel deficiencies. On sophisticated leadership-class supercomputers, such as the 28-rack 5.9 petaFLOP IBM Blue Gene/Q 'JUQUEEN' of the Jülich Supercomputing Centre (JSC), this is a challenging task, but even more so important, when complex coupled component models are to be analysed. Here we want to present our experience from coupling, application tuning (e.g. 5-times speedup through compiler optimizations), parallel scaling and performance monitoring of the parallel Terrestrial Systems Modeling Platform TerrSysMP. The modeling platform consists of the weather prediction system COSMO of the German Weather Service; the Community Land Model, CLM of NCAR; and the variably saturated surface-subsurface flow code ParFlow. The model system relies on the Multiple Program Multiple Data (MPMD) execution model where the external Ocean-Atmosphere-Sea-Ice-Soil coupler (OASIS3) links the component models. TerrSysMP has been instrumented with the performance analysis tool Scalasca and analyzed

  15. (210)Pb as a tracer of soil erosion, sediment source area identification and particle transport in the terrestrial environment.

    Science.gov (United States)

    Matisoff, Gerald

    2014-12-01

    Although (137)Cs has been used extensively to study soil erosion and particle transport in the terrestrial environment, there has been much less work using excess or unsupported (210)Pb ((210)Pbxs) to study the same processes. Furthermore, since (137)Cs activities in soils are decreasing because of radioactive decay, some locations have an added complication due to the addition of Chernobyl-derived (137)Cs, and the activities of (137)Cs in the southern hemisphere are low, there is a need to develop techniques that use (210)Pbxs to provide estimates of rates of soil erosion and particle transport. This paper reviews the current status of (210)Pbxs methods to quantify soil erosion rates, to identify and partition suspended sediment source areas, and to determine the transport rates of particles in the terrestrial landscape. Soil erosion rates determined using (210)Pbxs are based on the unsupported (210)Pb ((210)Pbxs) inventory in the soil, the depth distribution of (210)Pbxs, and a mass balance calibration ('conversion model') that relates the soil inventory to the erosion rate using a 'reference site' at which neither soil erosion nor soil deposition has occurred. In this paper several different models are presented to illustrate the effects of different model assumptions such as the timing, depth and rates of the surface soil mixing on the calculated erosion rates. The suitability of model assumptions, including estimates of the depositional flux of (210)Pbxs to the soil surface and the post-depositional mobility of (210)Pb are also discussed. (210)Pb can be used as one tracer to permit sediment source area identification. This sediment 'fingerprinting' has been extended far beyond using (210)Pb as a single radioisotope to include numerous radioactive and stable tracers and has been applied to identifying the source areas of suspended sediment based on underlying rock type, land use (roads, stream banks, channel beds, cultivated or uncultivated lands, pasture lands

  16. Natural analogue working group

    International Nuclear Information System (INIS)

    Come, B.; Chapman, N.

    1986-01-01

    A Natural Analogue Working Group was established by the Commission of the European Communities in 1985. The purpose of this group is to bring together modellers with earth scientists and others, so that maximum benefit can be obtained from natural analogue studies with a view to safe geological disposal of radioactive waste. The first meeting of this group was held in Brussels from November 5 to 7, 1985. The discussions mainly concerned the identification of the modellers' needs and of the earth scientists' capacity to provide for them. Following the debates, a written statement was produced by the Group; this document forms the core of the present Report. Notes and outlines of many of the presentations made are grouped in four appendixes. The valuable contribution of all those involved in the meeting is gratefully acknowledged

  17. Analogues of uracil nucleosides with intrinsic fluorescence (NIF-analogues): synthesis and photophysical properties.

    Science.gov (United States)

    Segal, Meirav; Fischer, Bilha

    2012-02-28

    Uridine cannot be utilized as fluorescent probe due to its extremely low quantum yield. For improving the uracil fluorescence characteristics we extended the natural chromophore at the C5 position by coupling substituted aromatic rings directly or via an alkenyl or alkynyl linker to create fluorophores. Extension of the uracil base was achieved by treating 5-I-uridine with the appropriate boronic acid under the Suzuki coupling conditions. Analogues containing an alkynyl linker were obtained from 5-I-uridine and the suitable boronic acid in a Sonogashira coupling reaction. The uracil fluorescent analogues proposed here were designed to satisfy the following requirements: a minimal chemical modification at a position not involved in base-pairing, resulting in relatively long absorption and emission wavelengths and high quantum yield. 5-((4-Methoxy-phenyl)-trans-vinyl)-2'-deoxy-uridine, 6b, was found to be a promising fluorescent probe. Probe 6b exhibits a quantum yield that is 3000-fold larger than that of the natural chromophore (Φ 0.12), maximum emission (478 nm) which is 170 nm red shifted as compared to uridine, and a Stokes shift of 143 nm. In addition, since probe 6b adopts the anti conformation and S sugar puckering favored by B-DNA, it makes a promising nucleoside analogue to be incorporated in an oligonucleotide probe for detection of genetic material.

  18. Ferrous archaeological analogues for the understanding of the multi-secular corrosion mechanisms in an anoxic environment

    International Nuclear Information System (INIS)

    Saheb-Djahromi, M.

    2009-12-01

    Understanding the long term corrosion mechanisms of iron in an anoxic environment is essential in the field of the radioactive waste storage. In France, it is planned to store high level nuclear wastes in a multi-barrier system containing a glassy matrix surrounded by a stainless steel container, embedded in a low-carbon steel over-container. This system would be placed in a deep geological repository, which would impose anoxic conditions. As it must be efficient for a period of several thousands of years, one should understand the alteration mechanisms that are expected to occur in such a long time. To this purpose, a specific approach is developed on ferrous archaeological analogues with thick corrosion layer formed in natural conditions. In this study, the corrosion mechanisms have been assessed by examining nails aged of 400 years coming from the archaeological site of Glinet, selected as a reference site. The first point was a fine characterisation of the entire corrosion system metal / corrosion products / medium, through the use of coupled multi-scale analytical tools. The first results showed that the samples were corroded in an anoxic calco-carbonated environment. Moreover, the coupling of X-ray micro-diffraction, Raman microspectroscopy and dispersive energy spectroscopy has enabled to identify three corrosion systems composed of iron carbonates, siderite and chukanovite, and magnetite. Depending on the phase's layout in the system, the electronic resistance of the corrosion layers has been established, from resistive to conductive. In a second stage, re-corroding experiments in laboratory were performed. Firstly, the electrochemical behaviour of the corrosion system has shown that water reduction at the metallic interface is negligible. Furthermore, reaction tracing with copper and deuterium has allowed identifying the electron consumptions sites mainly localised on the external part, and the precipitation sites on the internal part of the corrosion

  19. Prospects for Detecting Thermal Emission from Terrestrial Exoplanets with JWST

    Science.gov (United States)

    Kreidberg, Laura

    2018-01-01

    A plethora of nearby, terrestrial exoplanets has been discovered recently by ground-based surveys. Excitingly, some of these are in the habitable zones of their host stars, and may be hospitable for life. However, all the planets orbit small, cool stars and have considerably different irradiation environments from the Earth, making them vulnerable to atmospheric escape, erosion and collapse. Atmosphere characterization is therefore critical to assessing the planets' habitability. I will discuss possible JWST thermal emission measurements to determine the atmospheric properties of nearby terrestrial planets. I will focus on prospects for detecting physically motivated atmospheres for planets orbiting LHS 1140, GJ 1132, and TRAPPIST-1. I will also discuss the potential for using phase curve observations to determine whether an atmosphere has survived on the non-transiting planet Proxima b.

  20. A Low-cost Multi-channel Analogue Signal Generator

    CERN Document Server

    Müller, F; The ATLAS collaboration; Shen, W; Stamen, R

    2009-01-01

    A scalable multi-channel analogue signal generator is presented. It uses a commercial low-cost graphics card with multiple outputs in a standard PC as signal source. Each color signal serves as independent channel to generate an analogue signal. A custom-built external PCB was developed to adjust the graphics card output voltage levels for a specific task, which needed differential signals. The system furthermore comprises a software package to program the signal shape. The signal generator was successfully used as independent test bed for the ATLAS Level-1 Trigger Pre-Processor, providing up to 16 analogue signals.

  1. Natural radiation in the environment

    International Nuclear Information System (INIS)

    Moeller, D.W.

    1990-01-01

    The speaker discusses natural radiation in the environment. He outlines the external sources of exposure (cosmic and terrestrial), as well as the internal sources (ingestion and inhalation). He states that a clear understanding of these sources and their impacts is necessary in order to properly evaluate both the environment and human radiation exposure

  2. Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.

    Science.gov (United States)

    Hindley, Stephen; Ward, Stephen A; Storr, Richard C; Searle, Natalie L; Bray, Patrick G; Park, B Kevin; Davies, Jill; O'Neill, Paul M

    2002-02-28

    The potent antimalarial activity of chloroquine against chloroquine-sensitive strains can be attributed, in part, to its high accumulation in the acidic environment of the heme-rich parasite food vacuole. A key component of this intraparasitic chloroquine accumulation mechanism is a weak base "ion-trapping" effect whereupon the basic drug is concentrated in the acidic food vacuole in its membrane-impermeable diprotonated form. By the incorporation of amino functionality into target artemisinin analogues, we hoped to prepare a new series of analogues that, by virtue of increased accumulation into the ferrous-rich vacuole, would display enhanced antimalarial potency. The initial part of the project focused on the preparation of piperazine-linked analogues (series 1 (7-16)). Antimalarial evaluation of these derivatives demonstrated potent activity versus both chloroquine-sensitive and chloroquine-resistant parasites. On the basis of these observations, we then set about preparing a series of C-10 carba-linked amino derivatives. Optimization of the key synthetic step using a newly developed coupling protocol provided a key intermediate, allyldeoxoartemisinin (17) in 90% yield. Further elaboration, in three steps, provided nine target C-10 carba analogues (series 2 (21-29)) in good overall yields. Antimalarial assessment demonstrated that these compounds were 4-fold more potent than artemisinin and about twice as active as artemether in vitro versus chloroquine-resistant parasites. On the basis of the products obtained from biomimetic Fe(II) degradation of the C-10 carba analogue (23), we propose that these analogues may have a mode of action subtly different from that of the parent drug artemisinin (series 1 (7-16)) and other C-10 ether derivatives such as artemether. Preliminary in vivo testing by the WHO demonstrated that four of these compounds are active orally at doses of less than 10 mg/kg. Since these analogues are available as water-soluble salts and cannot

  3. Synthesis of an Orthogonal Topological Analogue of Helicene

    DEFF Research Database (Denmark)

    Wixe, Torbjörn; Wallentin, Carl‐Johan; Johnson, Magnus T.

    2013-01-01

    The synthesis of an orthogonal topological pentamer analogue of helicene is presented. This analogue forms a tubular structure with its aromatic systems directed parallel to the axis of propagation, which creates a cavity with the potential to function as a host molecule. The synthetic strategy r...

  4. Climatic change and environmental implications in the Medicine Hat region using Billings, Montana as an analogue

    International Nuclear Information System (INIS)

    Proudfoot, W.A.

    1994-01-01

    There is concern that climatic change due to anthropogenic enhancement of the greenhouse effect may have considerable impacts on the natural and agricultural environments in Canada. The Palliser Triangle in the southern prairie region is an area in which the impacts of climatic change could be significant; it is an important agricultural zone and is already sensitive due to its semi-arid climate. The possible effects of a change in the climate of the Medicine Hat (Alberta) area in the Palliser Triangle is examined through the use of a regional analogue in a warmer, more southerly area. The selected analogue region is the area around Billings, Montana. Aspects of the natural environment, including potential vegetation distribution, frost-free period, and drought, as well as aspects of the agricultural environment, including agricultural practices and examination of wheat yields, are studied within each region. Comparisons are drawn between the two regions to evaluate whether significant differences exist in the environmental aspects examined. It is shown that although a change in Medicine Hat's climate to one more like that of Billings may not have drastic impacts on the environment, such a change may require adjustments in current practices or adaptations to altered environmental conditions. Reviews of several policy areas will be necessary to ensure appropriate adjustments in agricultural or resource management practices. Regional analogy is shown to be an essential preliminary tool for determining possible effects of climatic change. 138 refs., 42 figs., 22 tabs

  5. Phosphorylation of inositol 1,4,5-trisphosphate analogues by 3-kinase and dephosphorylation of inositol 1,3,4,5-tetrakisphosphate analogues by 5-phosphatase

    NARCIS (Netherlands)

    Dijken, Peter van; Lammers, Aleida A.; Ozaki, Shoichiro; Potter, Barry V.L.; Erneux, Christophe; Haastert, Peter J.M. van

    1994-01-01

    A series of P-32-labeled D-myo-inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P-4] analogues was enzymically prepared from the corresponding D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P-3] analogues using recombinant rat brain Ins(1,4,5)P-3 3-kinase and [gamma-P-32]ATP. Ins(1,4,5)P-3 analogues

  6. Fungal decomposition of terrestrial organic matter accelerated Early Jurassic climate warming

    Science.gov (United States)

    Pieńkowski, Grzegorz; Hodbod, Marta; Ullmann, Clemens V.

    2016-08-01

    Soils - constituting the largest terrestrial carbon pool - are vulnerable to climatic warming. Currently existing uncertainties regarding carbon fluxes within terrestrial systems can be addressed by studies of past carbon cycle dynamics and related climate change recorded in sedimentary successions. Here we show an example from the Early Jurassic (early Toarcian, c. 183 mya) marginal-marine strata from Poland, tracking the hinterland response to climatic changes through a super-greenhouse event. In contrast to anoxia-related enhanced carbon storage in coeval open marine environments, Total Organic Carbon (TOC) concentrations in the Polish successions are substantially reduced during this event. Increasing temperature favoured fungal-mediated decomposition of plant litter - specifically of normally resistant woody tissues. The associated injection of oxidized organic matter into the atmosphere corresponds to abrupt changes in standing vegetation and may have contributed significantly to the amplified greenhouse climate on Earth. The characteristic Toarcian signature of multiple warm pulses coinciding with rapidly decreasing carbon isotope ratios may in part be the result of a radical reduction of the terrestrial carbon pool as a response to climate change.

  7. On the robustness of entanglement in analogue gravity systems

    International Nuclear Information System (INIS)

    Bruschi, D E; Friis, N; Fuentes, I; Weinfurtner, S

    2013-01-01

    We investigate the possibility of generating quantum-correlated quasi-particles utilizing analogue gravity systems. The quantumness of these correlations is a key aspect of analogue gravity effects and their presence allows for a clear separation between classical and quantum analogue gravity effects. However, experiments in analogue systems, such as Bose–Einstein condensates (BECs) and shallow water waves, are always conducted at non-ideal conditions, in particular, one is dealing with dispersive media at non-zero temperatures. We analyse the influence of the initial temperature on the entanglement generation in analogue gravity phenomena. We lay out all the necessary steps to calculate the entanglement generated between quasi-particle modes and we analytically derive an upper bound on the maximal temperature at which given modes can still be entangled. We further investigate a mechanism to enhance the quantum correlations. As a particular example, we analyse the robustness of the entanglement creation against thermal noise in a sudden quench of an ideally homogeneous BEC, taking into account the super-sonic dispersion relations. (paper)

  8. Analogue Signal Processing: Collected Papers 1994-95

    DEFF Research Database (Denmark)

    1996-01-01

    This document is a collection of the papers presented at international conferences and in international journals by the analogue signal processing group of Electronics Institute, Technical University of Denmark, in 1994 and 1995.......This document is a collection of the papers presented at international conferences and in international journals by the analogue signal processing group of Electronics Institute, Technical University of Denmark, in 1994 and 1995....

  9. Smart Rotorcraft Field Assistants for Terrestrial and Planetary Science

    Science.gov (United States)

    Young, Larry A.; Aiken, Edwin W.; Briggs, Geoffrey A.

    2004-01-01

    Field science in extreme terrestrial environments is often difficult and sometimes dangerous. Field seasons are also often short in duration. Robotic field assistants, particularly small highly mobile rotary-wing platforms, have the potential to significantly augment a field season's scientific return on investment for geology and astrobiology researchers by providing an entirely new suite of sophisticated field tools. Robotic rotorcraft and other vertical lift planetary aerial vehicle also hold promise for supporting planetary science missions.

  10. Investigations of radiocaesium in the natural terrestrial environment in Norway following the Chernobyl accident

    International Nuclear Information System (INIS)

    Bretten, S.; Steinnes, E.

    1992-01-01

    Radioactive fallout from the Chernobyl accident affected parts of central Norway to a considerable extent, in particular the 134 Cs + 137 Cs deposition had a significant impact on the natural environment. When this became apparent, a comprehensive radioecological research programme was initiated in order to study the behaviour of radiocaesium in boreal and alpine ecosystems, with emphasis on food-chains leading to exposure of species used for human consumption, i.e., reindeer and freshwater fish. In this paper results from the terrestrial part of this research programme during the period 1986-1990 are presented. The work was mainly confined to the mountain areas of Dovre and Rondane. Parallel studies were performed in eutrophic and strongly oligotrophic communities. The influence of local variations in topography and microclimate on the observed radiocaesium levels in topsoils, lichens and vascular plants was studied in detail. Currently a significant re-distribution of radiocaesium from the originally strongly exposed surfaces to those that were less exposed is observed. In the soil, radiocaesium is strongly retained in the litter and raw humus layers. Current levels in lichens are 1-2 orders of magnitude higher than in vascular plants. This strongly affects the seasonal variation of radiocaesium in reindeer, showing winter maxima of about 5 times higher than the August levels. The radiocaesium levels in reindeer showed a decline of approximately a factor of 3 during the period 1987-1990. Other animal species studied in the programme exhibited substantially lower radiocaesium levels than reindeer, but a considerable interspecies variation was observed. (author)

  11. Terrestrial mollusk records from Chinese loess sequences and changes in the East Asian monsoonal environment

    Science.gov (United States)

    Wu, Naiqin; Li, Fengjiang; Rousseau, Denis-Didier

    2018-04-01

    The terrestrial mollusk fossils found in Chinese loess strata have been studied for over one hundred years. However, the greatest progress in these studies has been made only in the last two decades. In this paper, we review the advancements, advantages and limitations of terrestrial mollusk studies in Chinese loess deposits. Improvements in research methods and approaches have allowed the extraction of more detailed paleoenvironmental and paleoclimatic information from mollusk assemblages. The broadened research scope and content have yielded many new findings and results. The mollusk record has thus become one of the most important proxies in the paleoenvironmental and paleoclimatic reconstruction of loess-paleosol sequences in China. The greatest progress in the studies of terrestrial mollusks in Chinese loess sequences can be summarized as follows: (1) modern mollusk assemblages can be classified into four ecotypes, based on their temperature and humidity requirements, including eurytopic, semi-aridiphilous and sub-humidiphilous, cold-aridiphilous, and thermo-humidiphilous types; (2) Quaternary mollusk assemblages can be modified into the following three ecological types: glacial loess, interglacial paleosol, and interstadial weakly-developed paleosol assemblages; (3) mollusk records successfully reveal long-term climatic and environmental changes reflective of the history of East Asian monsoonal variations since the Late Cenozoic, and the succession of mollusk species also indicate short-term environmental changes such as millennial climate variability during Last Glacial Maximum and unstable climatic fluctuations during glacial and interglacial periods; and (4) more recently, new analytical approaches have offered increased research potential in areas such as paleotemperature reconstruction using the isotopic compositions of modern and fossil mollusk shells, combined with higher accuracy 14C dating of Quaternary loess deposits, which will greatly improve

  12. A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues

    Directory of Open Access Journals (Sweden)

    Arno Verlee

    2017-02-01

    Full Text Available For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonylbenzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues.

  13. On Using Current Steering Logic in Mixed Analogue-digital Circuits

    DEFF Research Database (Denmark)

    Lehmann, Torsten

    1998-01-01

    The authors investigate power supply noise in mixed analogue-digital circuits, arising from communication between the analogue and digital parts of the circuit. Current steering techniques and proper buffering are used to show which noise currents can be reduced and which cannot. In addition......, a high-swing current steering buffer for driving analogue switches or external digital signals is proposed....

  14. Dissolution studies of natural analogues spent fuel and U(VI)-Silicon phases of and oxidative alteration process

    International Nuclear Information System (INIS)

    Perez Morales, I.

    2000-01-01

    In order to understand the long-term behavior of the nuclear spent fuel in geological repository conditions, we have performed dissolution studies with natural analogues to UO 2 as well as with solid phases representatives of the oxidative alteration pathway of uranium dioxide, as observed in both natural environment and laboratory studies. In all cases, we have studied the influence of the bicarbonate concentration in the dissolution process, as a first approximation to the groundwater composition of a granitic environment, where carbonate is one of the most important complexing agents. As a natural analogue to the nuclear spent fuel some uraninite samples from the Oklo are deposit in Gabon, where chain fission reactions took place 2000 millions years ago, as well as a pitchblende sample from the mine Fe ore deposit, in Salamanca (spain) have been studied. The studies have been performed at 25 and 60 deg C and 60 deg C, and they have focussed on the determination of both the thermodynamic and the kinetic properties of the different samples studied, using batch and continuous experimental methodologies, respectively. (Author)

  15. UK Natural Analogue Coordinating Group: fourth annual report

    International Nuclear Information System (INIS)

    Read, D.; Hooker, P.J.

    1992-01-01

    HMIP has a research programme investigating some naturally radioactive sites as geochemical analogues of radionuclide migration. All of the analogue sites under investigation, both in the U.K. and overseas, are located where elevated uranium concentrations occur naturally. Coordination of the programme is achieved through the UK Natural Analogue Co-ordinating Group (NACG) which has met three times in this reporting period. The NACG is steered by the British Geological Survey. Its purpose is to ensure that the different research projects have an integrated function aimed at increasing our understanding of natural geochemical processes. Effort is also being expended in testing research models which may be used in such assessments. (author)

  16. Thermal regulation in terrestrial environment using a two-phase fluid loop with capillary pumping; Regulation thermique en environnement terrestre par boucle fluide diphasique a pompage capillaire

    Energy Technology Data Exchange (ETDEWEB)

    Butto, C [Universite Paul Sabatier, LESETH, 31 - Toulouse (France)

    1997-12-31

    Two-phase fluid loops with capillary pumping are particularly interesting silent devices which allow energy savings and do not create any noise pollution (no mechanical vibrations). In terrestrial environment, the gravity field, when judiciously used, allows to improve their performances and thus, their use in thermal regulation of big computers, power electronic components, transformers, etc, is particularly interesting. In this study, the main results concerning the functioning of such a loop in the gravity field are presented and used to highlight the conditions that allow to take advantage of this field and the improvements obtained. (J.S.) 5 refs.

  17. Thermal regulation in terrestrial environment using a two-phase fluid loop with capillary pumping; Regulation thermique en environnement terrestre par boucle fluide diphasique a pompage capillaire

    Energy Technology Data Exchange (ETDEWEB)

    Butto, C. [Universite Paul Sabatier, LESETH, 31 - Toulouse (France)

    1996-12-31

    Two-phase fluid loops with capillary pumping are particularly interesting silent devices which allow energy savings and do not create any noise pollution (no mechanical vibrations). In terrestrial environment, the gravity field, when judiciously used, allows to improve their performances and thus, their use in thermal regulation of big computers, power electronic components, transformers, etc, is particularly interesting. In this study, the main results concerning the functioning of such a loop in the gravity field are presented and used to highlight the conditions that allow to take advantage of this field and the improvements obtained. (J.S.) 5 refs.

  18. Amphibians at risk? Susceptibility of terrestrial amphibian life stages to pesticides.

    Science.gov (United States)

    Brühl, Carsten A; Pieper, Silvia; Weber, Brigitte

    2011-11-01

    Current pesticide risk assessment does not specifically consider amphibians. Amphibians in the aquatic environment (aquatic life stages or postmetamorphic aquatic amphibians) and terrestrial living juvenile or adult amphibians are assumed to be covered by the risk assessment for aquatic invertebrates and fish, or mammals and birds, respectively. This procedure has been evaluated as being sufficiently protective regarding the acute risk posed by a number of pesticides to aquatic amphibian life stages (eggs, larvae). However, it is unknown whether the exposure and sensitivity of terrestrial living amphibians are comparable to mammalian and avian exposure and sensitivity. We reviewed the literature on dermal pesticide absorption and toxicity studies for terrestrial life stages of amphibians, focusing on the dermal exposure pathway, that is, through treated soil or direct overspray. In vitro studies demonstrated that cutaneous absorption of chemicals is significant and that chemical percutaneous passage, P (cm/h), is higher in amphibians than in mammals. In vivo, the rapid and substantial uptake of the herbicide atrazine from treated soil by toads (Bufo americanus) has been described. Severe toxic effects on various amphibian species have been reported for field-relevant application rates of different pesticides. In general, exposure and toxicity studies for terrestrial amphibian life stages are scarce, and the reported data indicate the need for further research, especially in light of the global amphibian decline. Copyright © 2011 SETAC.

  19. Backbone modified TBA analogues endowed with antiproliferative activity.

    Science.gov (United States)

    Esposito, Veronica; Russo, Annapina; Amato, Teresa; Varra, Michela; Vellecco, Valentina; Bucci, Mariarosaria; Russo, Giulia; Virgilio, Antonella; Galeone, Aldo

    2017-05-01

    The thrombin binding aptamer (TBA) is endowed with antiproliferative properties but its potential development is counteracted by the concomitant anticoagulant activity. Five oligonucleotides (ODNs) based on TBA sequence (GGTTGGTGTGGTTGG) and containing l-residues or both l-residues and inversion of polarity sites have been investigated by NMR and CD techniques for their ability to form G-quadruplex structures. Furthermore, their anticoagulant (PT assay) and antiproliferative properties (MTT assay), and their resistance in fetal bovine serum have been tested. CD and NMR data suggest that the investigated ODNs are able to form right- and left-handed G-quadruplex structures. All ODNs do not retain the anticoagulant activity characteristic of TBA but are endowed with a significant antiproliferative activity against two cancerous cell lines. Their resistance in biological environment after six days is variable, depending on the ODN. A comparison between results and literature data suggests that the antiproliferative activity of the TBA analogues investigated could depends on two factors: a) biological pathways and targets different from those already identified or proposed for other antiproliferative G-quadruplex aptamers, and b) the contribution of the guanine-based degradation products. Modified TBA analogues containing l-residues and inversion of polarity sites lose the anticoagulant activity but gain antiproliferative properties against two cancer cell lines. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Quantitative Morphometric Analysis of Terrestrial Glacial Valleys and the Application to Mars

    Science.gov (United States)

    Allred, Kory

    Although the current climate on Mars is very cold and dry, it is generally accepted that the past environments on the planet were very different. Paleo-environments may have been warm and wet with oceans and rivers. And there is abundant evidence of water ice and glaciers on the surface as well. However, much of that comes from visual interpretation of imagery and other remote sensing data. For example, some of the characteristics that have been utilized to distinguish glacial forms are the presence of landscape features that appear similar to terrestrial glacial landforms, constraining surrounding topography, evidence of flow, orientation, elevation and valley shape. The main purpose of this dissertation is to develop a model that uses quantitative variables extracted from elevation data that can accurately categorize a valley basin as either glacial or non-glacial. The application of this model will limit the inherent subjectivity of image analysis by human interpretation. The model developed uses hypsometric attributes (elevation-area relationship), a newly defined variable similar to the equilibrium line altitude for an alpine glacier, and two neighborhood search functions intended to describe the valley cross-sectional curvature, all based on a digital elevation model (DEM) of a region. The classification model uses data-mining techniques trained on several terrestrial mountain ranges in varied geologic and geographic settings. It was applied to a select set of previously catalogued locations on Mars that resemble terrestrial glaciers. The results suggest that the landforms do have a glacial origin, thus supporting much of the previous research that has identified the glacial landforms. This implies that the paleo-environment of Mars was at least episodically cold and wet, probably during a period of increased planetary obliquity. Furthermore, the results of this research and the implications thereof add to the body of knowledge for the current and past

  1. Polonium-210 and lead-210 in the terrestrial environment: a historical review.

    Science.gov (United States)

    Persson, Bertil R R; Holm, Elis

    2011-05-01

    The radionuclides (210)Po and (210)Pb widely present in the terrestrial environment are the final long-lived radionuclides in the decay of (238)U in the earth's crust. Their presence in the atmosphere is due to the decay of (222)Rn diffusing from the ground. The range of activity concentrations in ground level air for (210)Po is 0.03-0.3 Bq m(-3) and for (210)Pb 0.2-1.5 Bq m(-3). In drinking water from private wells the activity concentration of (210)Po is in the order of 7-48 mBq l(-1) and for (210)Pb around 11-40 mBq l(-1). From water works, however, the activity concentration for both (210)Po and (210)Pb is only in the order of 3 mBq l(-1). Mosses, lichens and peat have a high efficiency in capturing (210)Po and (210)Pb from atmospheric fallout and exhibit an inventory of both (210)Po and (210)Pb in the order of 0.5-5 kBq m(-2) in mosses and in lichens around 0.6 kBq m(-2). The activity concentrations in lichens lies around 250 Bq kg(-1), dry mass. Reindeer and caribou graze lichen which results in an activity concentration of (210)Po and (210)Pb of about 1-15 Bq kg(-1) in meat from these animals. The food chain lichen-reindeer or caribou, and Man constitutes a unique model for studying the uptake and retention of (210)Po and (210)Pb in humans. The effective annual dose due to (210)Po and (210)Pb in people with high consumption of reindeer/caribou meat is estimated to be around 260 and 132 μSv a(-1) respectively. In soils, (210)Po is adsorbed to clay and organic colloids and the activity concentration varies with soil type and also correlates with the amount of atmospheric precipitation. The average activity concentration levels of (210)Po in various soils are in the range of 20-240 Bq kg(-1). Plants become contaminated with radioactive nuclides both by absorption from the soil (supported Po) and by deposition of radioactive fallout on the plants directly (unsupported Po). In fresh leafy plants the level of (210)Po is particularly high as the result of the

  2. Polonium-210 and lead-210 in the terrestrial environment: a historical review

    International Nuclear Information System (INIS)

    Persson, Bertil R.R.; Holm, Elis

    2011-01-01

    The radionuclides 210 Po and 210 Pb widely present in the terrestrial environment are the final long-lived radionuclides in the decay of 238 U in the earth's crust. Their presence in the atmosphere is due to the decay of 222 Rn diffusing from the ground. The range of activity concentrations in ground level air for 210 Po is 0.03-0.3 Bq m -3 and for 210 Pb 0.2-1.5 Bq m -3 . In drinking water from private wells the activity concentration of 210 Po is in the order of 7-48 mBq l -1 and for 210 Pb around 11-40 mBq l -1 . From water works, however, the activity concentration for both 210 Po and 210 Pb is only in the order of 3 mBq l -1 . Mosses, lichens and peat have a high efficiency in capturing 210 Po and 210 Pb from atmospheric fallout and exhibit an inventory of both 210 Po and 210 Pb in the order of 0.5-5 kBq m -2 in mosses and in lichens around 0.6 kBq m -2 . The activity concentrations in lichens lies around 250 Bq kg -1 , dry mass. Reindeer and caribou graze lichen which results in an activity concentration of 210 Po and 210 Pb of about 1-15 Bq kg -1 in meat from these animals. The food chain lichen-reindeer or caribou, and Man constitutes a unique model for studying the uptake and retention of 210 Po and 210 Pb in humans. The effective annual dose due to 210 Po and 210 Pb in people with high consumption of reindeer/caribou meat is estimated to be around 260 and 132 μSv a -1 respectively. In soils, 210 Po is adsorbed to clay and organic colloids and the activity concentration varies with soil type and also correlates with the amount of atmospheric precipitation. The average activity concentration levels of 210 Po in various soils are in the range of 20-240 Bq kg -1 . Plants become contaminated with radioactive nuclides both by absorption from the soil (supported Po) and by deposition of radioactive fallout on the plants directly (unsupported Po). In fresh leafy plants the level of 210 Po is particularly high as the result of the direct deposition of 222 Rn

  3. Analogue computer display of accelerator beam optics

    International Nuclear Information System (INIS)

    Brand, K.

    1984-01-01

    Analogue computers have been used years ago by several authors for the design of magnetic beam handling systems. At Bochum a small analogue/hybrid computer was combined with a particular analogue expansion and logic control unit for beam transport work. This apparatus was very successful in the design and setup of the beam handling system of the tandem accelerator. The center of the stripper canal was the object point for the calculations, instead of the high energy acceleration tube a drift length was inserted into the program neglecting the weak focusing action of the tube. In the course of the installation of a second injector for heavy ions it became necessary to do better calculations. A simple method was found to represent accelerating sections on the computer and a particular way to simulate thin lenses was adopted. The analogue computer system proved its usefulness in the design and in studies of the characteristics of different accelerator installations over many years. The results of the calculations are in very good agreement with real accelerator data. The apparatus is the ideal tool to demonstrate beam optics to students and accelerator operators since the effect of a change of any of the parameters is immediately visible on the oscilloscope

  4. The IRSN's earliest assessments of the Fukushima accident's consequences for the terrestrial environment in Japan

    International Nuclear Information System (INIS)

    Champion, D.; Korsakissok, I.; Didier, D.; Mathieu, A.; Quelo, D.; Groell, J.; Quentric, E.; Tombette, M.; Benoit, J.P.; Saunier, O.; Parache, V.; Simon-Cornu, M.; Gonze, M.A.; Renaud, Ph.; Cessac, B.; Navarro, E.; Servant-Perrier, A.C.

    2013-01-01

    In 2011 the IRSN conducted several assessments of atmospheric radioactive releases due to the Fukushima Daiichi NPP accident (March 11, 2011) and of their impact on Japan's terrestrial environment. They were based on the IRSN's emergency management tools and on the abundant information and technical data gradually published in Japan. According to these assessments, the main release phase lasted from March 12 to 25, 2011 and impacted Japanese land in two events, the first on 15 and 16 March, in which the main radioactive deposits were formed, and the second from March 20 to 23, which was less significant. The highest amounts of radioactive deposits were found in an area extending upwards of several tens of kilometers northwest of the plant. Lower amounts were discontinuously scattered in an area extending up to over 250 km away. Initially composed mainly of short-lived radionuclides, the deposits' activity sharply decreased in the subsequent weeks. Since the summer of 2011, cesium-134 and cesium-137 have become the residual deposits' main components. According to IRSN estimates, in the absence of protection, the doses due to exposure to the radioactive plume during the atmospheric release phase may have been potentially higher for people who remained in coastal areas up to several tens of kilometers north and south of the damaged plant. Thereafter, people living up to 50 km northwest of the plant, outside the 20-km emergency evacuation zone, were potentially most vulnerable to residual radioactive deposits over time. (authors)

  5. Terrestrial planet formation.

    Science.gov (United States)

    Righter, K; O'Brien, D P

    2011-11-29

    Advances in our understanding of terrestrial planet formation have come from a multidisciplinary approach. Studies of the ages and compositions of primitive meteorites with compositions similar to the Sun have helped to constrain the nature of the building blocks of planets. This information helps to guide numerical models for the three stages of planet formation from dust to planetesimals (~10(6) y), followed by planetesimals to embryos (lunar to Mars-sized objects; few 10(6) y), and finally embryos to planets (10(7)-10(8) y). Defining the role of turbulence in the early nebula is a key to understanding the growth of solids larger than meter size. The initiation of runaway growth of embryos from planetesimals ultimately leads to the growth of large terrestrial planets via large impacts. Dynamical models can produce inner Solar System configurations that closely resemble our Solar System, especially when the orbital effects of large planets (Jupiter and Saturn) and damping mechanisms, such as gas drag, are included. Experimental studies of terrestrial planet interiors provide additional constraints on the conditions of differentiation and, therefore, origin. A more complete understanding of terrestrial planet formation might be possible via a combination of chemical and physical modeling, as well as obtaining samples and new geophysical data from other planets (Venus, Mars, or Mercury) and asteroids.

  6. Analogue Signal Processing: Collected Papers 1996-97

    DEFF Research Database (Denmark)

    1997-01-01

    This document is a collection of the papers presented at international conferences and in international journals by the analogue signal processing group of the Department of Information Technology, Technical University of Denmark, in 1996 and 1997.......This document is a collection of the papers presented at international conferences and in international journals by the analogue signal processing group of the Department of Information Technology, Technical University of Denmark, in 1996 and 1997....

  7. Análogos de insulina Insulin analogues

    Directory of Open Access Journals (Sweden)

    Manuel E. Licea Puig

    2006-12-01

    diabetes mellitus (DM. The recombinant technology of deoxyribonucleic acid (DNA has allowed the development of human insulin; however, this has not totally solved the problems related to immunogenecity, among other problems. Therefore, the new technologies are applied to create insulin analogues. It is our purpose to review relevant pharmacological and clinical aspects related to the insulin analogues, as well as their usefulness in the treatment of DM. The insulin analogues result from biochemical modifications of human insulin. These modifications of the insulin molecule alter not only the absorption, but also the beginning and duration of the action, which offer advantages over the conventional insulins. At present, there are three rapid acting insulin analogues: insulin lispro, insulin aspart and glulisine; and three long acting analogues; glargine, detemir and albulin. Albulin is the latest long acting analogue reported. At present, it is being subjected to various in vitro and in vivo studies. Besides, there have been developed diverse formulations where the rapid acting insulin analogues are premixed with the long acting analogues. The rapid acting insulin analogues have showed a modest global benefit against the conventional insulins in type 1 diabetics. The long acting analogues focus their attention in those persons with DM with nocturnal hypoglycemic episodes. Longer term studies are necessary to confirm the safety and benefits of these preparations, as well as to determine their effect on the micro- and macroangiopathic complications of DM.

  8. Consequences of simulating terrestrial N dynamics for projecting future terrestrial C storage

    Science.gov (United States)

    Zaehle, S.; Friend, A. D.; Friedlingstein, P.

    2009-04-01

    We present results of a new land surface model, O-CN, which includes a process-based coupling between the terrestrial cycling of energy, water, carbon, and nitrogen. The model represents the controls of the terrestrial nitrogen (N) cycling on carbon (C) pools and fluxes through photosynthesis, respiration, changes in allocation patterns, as well as soil organic matter decomposition, and explicitly accounts for N leaching and gaseous losses. O-CN has been shown to give realistic results in comparison to observations at a wide range of scales, including in situ flux measurements, productivity databases, and atmospheric CO2 concentration data. Notably, O-CN simulates realistic responses of net primary productivity, foliage area, and foliage N content to elevated atmospheric [CO2] as evidenced at free air carbon dioxide enrichment (FACE) sites (Duke, Oak Ridge). We re-examine earlier model-based assessments of the terrestrial C sequestration potential using a global transient O-CN simulation driven by increases in atmospheric [CO2], N deposition and climatic changes over the 21st century. We find that accounting for terrestrial N cycling about halves the potential to store C in response to increases in atmospheric CO2 concentrations; mainly due to a reduction of the net C uptake in temperate and boreal forests. Nitrogen deposition partially alleviates the effect of N limitation, but is by far not sufficient to compensate for the effect completely. These findings underline the importance of an accurate representation of nutrient limitations in future projections of the terrestrial net CO2 exchanges and therefore land-climate feedback studies.

  9. Chemopreventive properties of curcumin analogues ...

    African Journals Online (AJOL)

    Chemopreventive properties of curcumin analogues, ... These compounds .... using microscope with 400 × magnification. APC ... Figure 3: Microscopic images of rat colorectal tissue stained with APC rabbit polyclonal antibody with different.

  10. Analogues to features and processes of a high-level radioactive waste repository proposed for Yucca Mountain, Nevada

    Science.gov (United States)

    Simmons, Ardyth M.; Stuckless, John S.; with a Foreword by Abraham Van Luik, U.S. Department of Energy

    2010-01-01

    Natural analogues are defined for this report as naturally occurring or anthropogenic systems in which processes similar to those expected to occur in a nuclear waste repository are thought to have taken place over time periods of decades to millennia and on spatial scales as much as tens of kilometers. Analogues provide an important temporal and spatial dimension that cannot be tested by laboratory or field-scale experiments. Analogues provide one of the multiple lines of evidence intended to increase confidence in the safe geologic disposal of high-level radioactive waste. Although the work in this report was completed specifically for Yucca Mountain, Nevada, as the proposed geologic repository for high-level radioactive waste under the U.S. Nuclear Waste Policy Act, the applicability of the science, analyses, and interpretations is not limited to a specific site. Natural and anthropogenic analogues have provided and can continue to provide value in understanding features and processes of importance across a wide variety of topics in addressing the challenges of geologic isolation of radioactive waste and also as a contribution to scientific investigations unrelated to waste disposal. Isolation of radioactive waste at a mined geologic repository would be through a combination of natural features and engineered barriers. In this report we examine analogues to many of the various components of the Yucca Mountain system, including the preservation of materials in unsaturated environments, flow of water through unsaturated volcanic tuff, seepage into repository drifts, repository drift stability, stability and alteration of waste forms and components of the engineered barrier system, and transport of radionuclides through unsaturated and saturated rock zones.

  11. Analogues of luteinizing hormone-releasing hormone containing cytotoxic groups.

    Science.gov (United States)

    Janáky, T; Juhász, A; Bajusz, S; Csernus, V; Srkalovic, G; Bokser, L; Milovanovic, S; Redding, T W; Rékási, Z; Nagy, A

    1992-02-01

    In an attempt to produce better cytotoxic analogues, chemotherapeutic antineoplastic radicals including an alkylating nitrogen mustard derivative of D-phenylalanine (D-melphalan), reactive cyclopropane, anthraquinone derivatives [2-(hydroxymethyl)anthraquinone and the anticancer antibiotic doxorubicin], and an antimetabolite (methotrexate) were coupled to suitably modified agonists and antagonists of luteinizing hormone-releasing hormone (LH-RH). Analogues with D-lysine6 and D-ornithine6 or N epsilon-(2,3-diaminopropionyl)-D-lysine and N delta-(2,3-diaminopropionyl)-D-ornithine were used as carriers for one or two cytotoxic moieties. The enhanced biological activities produced by the incorporation of D amino acids into position 6 of the agonistic analogues were further increased by the attachment of hydrophobic cytotoxic groups, resulting in compounds with 10-50 times higher activity than LH-RH. Most of the monosubstituted agonistic analogues showed high affinities for the membrane receptors of human breast cancer cells, while the receptor binding affinities of peptides containing two cytotoxic side chains were lower. Antagonistic carriers [Ac-D-Nal(2)1,D-Phe(4Cl)2,D-Trp3,Arg5,D-Lys6,D-Ala10] LH-RH [where Nal(2) is 3-(2-naphthyl)alanine], [Ac-D-Nal(2)1,D-Phe(4Cl)2,D-Trp3,Arg5,N epsilon-(2,3-diaminopropionyl)-D-Lys6,D-Ala10]LH-RH, and their D-Pal(3)3 homologs [Pal(3) is 3-(3-pyridyl)alanine] as well as [Ac-D-Nal(2)1,D-Phe(4Cl)2,D-Pal(3)3,Tyr5,N epsilon-(2,3-diamino-propionyl)-D-Lys6,D-Ala10]LH-RH were linked to cytotoxic compounds. The hybrid molecules inhibited ovulation in rats at doses of 10 micrograms and suppressed LH release in vitro. The receptor binding of cytotoxic analogues was decreased compared to the precursor peptides, although analogues with 2-(hydroxymethyl)anthraquinone hemiglutarate had high affinities. All of the cytotoxic analogues tested inhibited [3H]thymidine incorporation into DNA in cultures of human breast and prostate cancer cell lines

  12. Insulin analogues and severe hypoglycaemia in type 1 diabetes

    DEFF Research Database (Denmark)

    Kristensen, P L; Hansen, L S; Jespersen, M J

    2012-01-01

    The effect of insulin analogues on glycaemic control is well-documented, whereas the effect on avoidance of severe hypoglycaemia remains tentative. We studied the frequency of severe hypoglycaemia in unselected patients with type 1 diabetes treated with insulin analogues, human insulin, or mixed...

  13. How stakeholders view the use of analogues in safety cases: PAMINA

    International Nuclear Information System (INIS)

    Atherton, Elizabeth; Bailey, Lucy

    2008-01-01

    The aim of this presentation is to provide an overview of some research that has been undertaken in the UK to investigate stakeholders' views of analogues. There are various reasons for using analogues including: to try and explain difficult concepts; to compare disposal facility features with familiar and/or natural systems; to provide an alternative, non-numerical line of reasoning to support the Safety Case conclusions; to provide evidence of behaviour over very long timescales, that cannot be achieved in the laboratory. There are some dangers when using analogues that people should be aware of: the analogue conditions may not be the same as those found in a disposal facility, so the analogue may have limited application. Some analogues may have negative implications, for example artefacts that have corroded. Analogues can be taken too far and used in inappropriate ways to try and support an assumption. So it is important to find out how stakeholders view the use of analogues in a safety case. NDA is involved in an EC funded project called Pamina (Performance Assessment Methodologies in Application). The project involves 26 partners from 11 European countries, plus other associated members and runs for 3 years from October 2006 to October 2009. The NDA is involved in several parts of the project: Exploring issues of modelling uncertainty; Evaluating effectiveness of approaches for communicating safety cases with stakeholders. NDA ran a workshop in October 2007 in Manchester. The aims of the workshop were to explore how different methods of communicating aspects of a safety case were received by stakeholders. The workshop presented stakeholders with: Examples of different repository concepts; Descriptions of barrier performance; Different ways of presenting numerical results; Use of natural analogues

  14. Defining reference conditions for acidified waters using a modern analogue approach

    International Nuclear Information System (INIS)

    Simpson, Gavin L.; Shilland, Ewan M.; Winterbottom, Julie M.; Keay, Janey

    2005-01-01

    Analogue matching is a palaeolimnological technique that aims to find matches for fossil sediment samples from a set of modern surface sediment samples. Modern analogues were identified that closely matched the pre-disturbance conditions of eight of the UK Acid Waters Monitoring Network (AWMN) lakes using diatom- and cladoceran-based analogue matching. These analogue sites were assessed in terms of hydrochemistry, aquatic macrophytes and macro-invertebrates as to their suitability for defining wider hydrochemical and biological reference conditions for acidified sites within the AWMN. The analogues identified for individual AWMN sites show a close degree of similarity in terms of their hydrochemical characteristics, aquatic macrophytes and, to a lesser extent, macro-invertebrate fauna. The reference conditions of acidified AWMN sites are inferred to be less acidic than today and to support a wider range of acid-sensitive aquatic macrophyte and macro-invertebrate taxa than that recorded in the AWMN lakes over the period of monitoring since 1988. - The use of a palaeolimnological technique to identify modern ecological reference analogues for acidified lakes is demonstrated

  15. Ecological transfer mechanisms - Terrestrial

    Energy Technology Data Exchange (ETDEWEB)

    Martin, W E; Raines, Gilbert E; Bloom, S G; Levin, A A [Battelle Memorial Institute, CoIumbus, OH (United States)

    1969-07-01

    Radionuclides produced by nuclear excavation detonations and released to the environment may enter a variety of biogeochemical cycles and follow essentially the same transfer pathways as their stable-element counterparts. Estimation of potential internal radiation doses to individuals and/or populations living in or near fallout-contaminated areas requires analysis of the food-chain and other ecological pathways by which radionuclides released to the environment may be returned to man. A generalized materials transfer diagram, applicable to the forest, agricultural, freshwater and marine ecosystems providing food and water to the indigenous population of Panama and Colombia in regions that could be affected by nuclear excavation of a sea-level canal between the Atlantic and Pacific Oceans, is presented. Transfer mechanisms effecting the movement of stable elements and radionuclides in terrestrial ecosystems are discussed, and methods used to simulate these processes by means of mathematical models are described to show how intake values are calculated for different radionuclides in the major ecological pathways leading to man. These data provide a basis for estimating potential internal radiation doses for comparison with the radiation protection criteria established by recognized authorities; and this, in turn, provides a basis for recommending measures to insure the radiological safety of the nuclear operation plan. (author)

  16. Ecological transfer mechanisms - Terrestrial

    International Nuclear Information System (INIS)

    Martin, W.E.; Raines, Gilbert E.; Bloom, S.G.; Levin, A.A.

    1969-01-01

    Radionuclides produced by nuclear excavation detonations and released to the environment may enter a variety of biogeochemical cycles and follow essentially the same transfer pathways as their stable-element counterparts. Estimation of potential internal radiation doses to individuals and/or populations living in or near fallout-contaminated areas requires analysis of the food-chain and other ecological pathways by which radionuclides released to the environment may be returned to man. A generalized materials transfer diagram, applicable to the forest, agricultural, freshwater and marine ecosystems providing food and water to the indigenous population of Panama and Colombia in regions that could be affected by nuclear excavation of a sea-level canal between the Atlantic and Pacific Oceans, is presented. Transfer mechanisms effecting the movement of stable elements and radionuclides in terrestrial ecosystems are discussed, and methods used to simulate these processes by means of mathematical models are described to show how intake values are calculated for different radionuclides in the major ecological pathways leading to man. These data provide a basis for estimating potential internal radiation doses for comparison with the radiation protection criteria established by recognized authorities; and this, in turn, provides a basis for recommending measures to insure the radiological safety of the nuclear operation plan. (author)

  17. The Martian atmospheric water cycle as viewed from a terrestrial perspective

    Science.gov (United States)

    Zurek, Richard W.

    1988-01-01

    It is noted that the conditions of temperature and pressure that characterize the atmosphere of Mars are similar to those found in the Earth's stratosphere. Of particular significance is the fact that liquid water is unstable in both environments. Thus, it is expected that terrestrial studies of the dynamical behavior of stratospheric water should benefit the understanding of water transport on Mars as well.

  18. Alligator Rivers Analogue project. Application of scenario development method in evaluation of the Koongarra Analogue. Final Report - Volume 16

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, K [Kemakta Consultants co., Stockholm (Sweden); Wingefors, S [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    1993-12-31

    The study of natural analogues has been established as one of the most important methods for validation of concepts and models applied for the assessment of long-term performance of repositories for nuclear waste. The objectives of such studies range from detailed investigations of processes and features on a small scale to attempts of explaining the evolution of whole sites. For studies of specific processes it may well be as important to consider the larger scale settings as boundary conditions. This appreciation of context and an integrated view may be as important for evaluation of most natural analogues as for performance assessments. This is more evident the more the evaluation depends on a knowledge about the evolution of the natural analogue. The attempted formulation of scenarios of the Koongarra Analogue has been based on the external conditions and external features. A rapid weathering of the host rock, i.e. the chlorite schist, is assumed to have started around the onset of the Pleistocene Ice Age (ca 1.6 Ma BP). The eventual oxidation and mobilization of the uranium ore could then have occurred under unsaturated or saturated conditions. This leads to the following major scenarios: (1) Uranyl Phosphates formed under unsaturated conditions, with a periodical evolution of the dispersion fan in conjunction with alternating dry (glacial) and wet (interglacial) periods during the Pleistocene Ice Age; (2) Uranyl Phosphates formed under unsaturated conditions as a single event, taking place either early or late during the Pleistocene Ice Age; (3)Uranyl Phosphates formed under saturated conditions, in conjunction with periods of higher and lower flow due to the climatic cycling. Although the original objectives may not have been fully achieved, this work is believed to contribute to a better understanding of the Koongarra Analogue as well as to give a basis for further scenario work

  19. Alligator Rivers Analogue project. Application of scenario development method in evaluation of the Koongarra Analogue. Final Report - Volume 16

    Energy Technology Data Exchange (ETDEWEB)

    Skagius, K. [Kemakta Consultants co., Stockholm (Sweden); Wingefors, S. [Swedish Nuclear Power Inspectorate, Stockholm (Sweden)

    1992-12-31

    The study of natural analogues has been established as one of the most important methods for validation of concepts and models applied for the assessment of long-term performance of repositories for nuclear waste. The objectives of such studies range from detailed investigations of processes and features on a small scale to attempts of explaining the evolution of whole sites. For studies of specific processes it may well be as important to consider the larger scale settings as boundary conditions. This appreciation of context and an integrated view may be as important for evaluation of most natural analogues as for performance assessments. This is more evident the more the evaluation depends on a knowledge about the evolution of the natural analogue. The attempted formulation of scenarios of the Koongarra Analogue has been based on the external conditions and external features. A rapid weathering of the host rock, i.e. the chlorite schist, is assumed to have started around the onset of the Pleistocene Ice Age (ca 1.6 Ma BP). The eventual oxidation and mobilization of the uranium ore could then have occurred under unsaturated or saturated conditions. This leads to the following major scenarios: (1) Uranyl Phosphates formed under unsaturated conditions, with a periodical evolution of the dispersion fan in conjunction with alternating dry (glacial) and wet (interglacial) periods during the Pleistocene Ice Age; (2) Uranyl Phosphates formed under unsaturated conditions as a single event, taking place either early or late during the Pleistocene Ice Age; (3)Uranyl Phosphates formed under saturated conditions, in conjunction with periods of higher and lower flow due to the climatic cycling. Although the original objectives may not have been fully achieved, this work is believed to contribute to a better understanding of the Koongarra Analogue as well as to give a basis for further scenario work

  20. Alligator Rivers Analogue project. Application of scenario development method in evaluation of the Koongarra Analogue. Final Report - Volume 16

    International Nuclear Information System (INIS)

    Skagius, K.; Wingefors, S.

    1992-01-01

    The study of natural analogues has been established as one of the most important methods for validation of concepts and models applied for the assessment of long-term performance of repositories for nuclear waste. The objectives of such studies range from detailed investigations of processes and features on a small scale to attempts of explaining the evolution of whole sites. For studies of specific processes it may well be as important to consider the larger scale settings as boundary conditions. This appreciation of context and an integrated view may be as important for evaluation of most natural analogues as for performance assessments. This is more evident the more the evaluation depends on a knowledge about the evolution of the natural analogue. The attempted formulation of scenarios of the Koongarra Analogue has been based on the external conditions and external features. A rapid weathering of the host rock, i.e. the chlorite schist, is assumed to have started around the onset of the Pleistocene Ice Age (ca 1.6 Ma BP). The eventual oxidation and mobilization of the uranium ore could then have occurred under unsaturated or saturated conditions. This leads to the following major scenarios: (1) Uranyl Phosphates formed under unsaturated conditions, with a periodical evolution of the dispersion fan in conjunction with alternating dry (glacial) and wet (interglacial) periods during the Pleistocene Ice Age; (2) Uranyl Phosphates formed under unsaturated conditions as a single event, taking place either early or late during the Pleistocene Ice Age; (3)Uranyl Phosphates formed under saturated conditions, in conjunction with periods of higher and lower flow due to the climatic cycling. Although the original objectives may not have been fully achieved, this work is believed to contribute to a better understanding of the Koongarra Analogue as well as to give a basis for further scenario work

  1. Flexibility-Rigidity Coordination of the Dense Exopolysaccharide Matrix in Terrestrial Cyanobacteria Acclimated to Periodic Desiccation.

    Science.gov (United States)

    Liu, Wen; Cui, Lijuan; Xu, Haiyan; Zhu, Zhaoxia; Gao, Xiang

    2017-11-15

    A dense exopolysaccharide (EPS) matrix is crucial for cyanobacterial survival in terrestrial xeric environments, in which cyanobacteria undergo frequent expansion and shrinkage processes during environmental desiccation-rehydration cycles. However, it is unclear how terrestrial cyanobacteria coordinate the structural dynamics of the EPS matrix upon expansion and shrinkage to avoid potential mechanical stress while benefiting from the matrix. In the present study, we sought to answer this question by investigating the gene expression, protein dynamics, enzymatic characteristics, and biological roles of WspA, an abundantly secreted protein, in the representative terrestrial cyanobacterium Nostoc flagelliforme The results demonstrated that WspA is a novel β-galactosidase that facilitates softening of the EPS matrix by breaking the polysaccharide backbone under substantial moisture or facilitates the thickening and relinkage of the broken matrix during the drying process, and thus these regulations are well correlated with moisture availability or desiccation-rehydration cycles. This coordination of flexibility and rigidity of the cyanobacterial extracellular matrix may contribute to a favorable balance of cell growth and stress resistance in xeric environments. IMPORTANCE How the exopolysaccharide matrix is dynamically coordinated by exoproteins to cope with frequent expansion and shrinkage processes in terrestrial colonial cyanobacteria remains unclear. Here we elucidated the biochemical identity and biological roles of a dominant exoprotein in these regulation processes. Our study thus gained insight into this regulative mechanism in cyanobacteria to combat periodic desiccation. In addition, the filamentous drought-adapted cyanobacterium Nostoc flagelliforme serves as an ideal model for us to explore this issue in this study. Copyright © 2017 American Society for Microbiology.

  2. The corrosion of depleted uranium in terrestrial and marine environments.

    Science.gov (United States)

    Toque, C; Milodowski, A E; Baker, A C

    2014-02-01

    Depleted Uranium alloyed with titanium is used in armour penetrating munitions that have been fired in a number of conflict zones and testing ranges including the UK ranges at Kirkcudbright and Eskmeals. The study presented here evaluates the corrosion of DU alloy cylinders in soil on these two UK ranges and in the adjacent marine environment of the Solway Firth. The estimated mean initial corrosion rates and times for complete corrosion range from 0.13 to 1.9 g cm(-2) y(-1) and 2.5-48 years respectively depending on the particular physical and geochemical environment. The marine environment at the experimental site was very turbulent. This may have caused the scouring of corrosion products and given rise to a different geochemical environment from that which could be easily duplicated in laboratory experiments. The rate of mass loss was found to vary through time in one soil environment and this is hypothesised to be due to pitting increasing the surface area, followed by a build up of corrosion products inhibiting further corrosion. This indicates that early time measurements of mass loss or corrosion rate may be poor indicators of late time corrosion behaviour, potentially giving rise to incorrect estimates of time to complete corrosion. The DU alloy placed in apparently the same geochemical environment, for the same period of time, can experience very different amounts of corrosion and mass loss, indicating that even small variations in the corrosion environment can have a significant effect. These effects are more significant than other experimental errors and variations in initial surface area. Copyright © 2013. Published by Elsevier Ltd.

  3. Vermicomposting and anaerobic digestion – viable alternative options for terrestrial weed management – A review

    Directory of Open Access Journals (Sweden)

    Biswanath Saha

    2018-03-01

    Full Text Available The management of terrestrial weed is of great concern for the scientific community as these weeds cause adverse effect in different ecosystems like forest, agriculture and urban. The widespread of these weeds by their adaptive capability and morphological advancement is difficult to control. Parthenium hysterophorous, Lantana camara, Saccharum spontaneum, Ageratum conyzoides are the weeds that spread all over the world. There are various management practices employed for the control of this weeds. But all of these practices have some drawbacks those are neither environment friendly nor economical. In this paper a review has been done to evaluate various alternative management practices for these terrestrial weeds and to analyze their feasibility. Vermicomposting and anaerobic digestion can be viable alternative option which is cost effective as well. There are few studies regarding vermicomposting and anaerobic digestions of terrestrial weeds are done.

  4. Aquatic carbon cycling in the conterminous United States and implications for terrestrial carbon accounting.

    Science.gov (United States)

    Butman, David; Stackpoole, Sarah; Stets, Edward; McDonald, Cory P; Clow, David W; Striegl, Robert G

    2016-01-05

    Inland water ecosystems dynamically process, transport, and sequester carbon. However, the transport of carbon through aquatic environments has not been quantitatively integrated in the context of terrestrial ecosystems. Here, we present the first integrated assessment, to our knowledge, of freshwater carbon fluxes for the conterminous United States, where 106 (range: 71-149) teragrams of carbon per year (TgC⋅y(-1)) is exported downstream or emitted to the atmosphere and sedimentation stores 21 (range: 9-65) TgC⋅y(-1) in lakes and reservoirs. We show that there is significant regional variation in aquatic carbon flux, but verify that emission across stream and river surfaces represents the dominant flux at 69 (range: 36-110) TgC⋅y(-1) or 65% of the total aquatic carbon flux for the conterminous United States. Comparing our results with the output of a suite of terrestrial biosphere models (TBMs), we suggest that within the current modeling framework, calculations of net ecosystem production (NEP) defined as terrestrial only may be overestimated by as much as 27%. However, the internal production and mineralization of carbon in freshwaters remain to be quantified and would reduce the effect of including aquatic carbon fluxes within calculations of terrestrial NEP. Reconciliation of carbon mass-flux interactions between terrestrial and aquatic carbon sources and sinks will require significant additional research and modeling capacity.

  5. Aquatic carbon cycling in the conterminous United States and implications for terrestrial carbon accounting

    Science.gov (United States)

    Butman, David; Stackpoole, Sarah; Stets, Edward; McDonald, Cory P.; Clow, David W.; Striegl, Robert G.

    2016-01-01

    Inland water ecosystems dynamically process, transport, and sequester carbon. However, the transport of carbon through aquatic environments has not been quantitatively integrated in the context of terrestrial ecosystems. Here, we present the first integrated assessment, to our knowledge, of freshwater carbon fluxes for the conterminous United States, where 106 (range: 71–149) teragrams of carbon per year (TgC⋅y−1) is exported downstream or emitted to the atmosphere and sedimentation stores 21 (range: 9–65) TgC⋅y−1 in lakes and reservoirs. We show that there is significant regional variation in aquatic carbon flux, but verify that emission across stream and river surfaces represents the dominant flux at 69 (range: 36–110) TgC⋅y−1 or 65% of the total aquatic carbon flux for the conterminous United States. Comparing our results with the output of a suite of terrestrial biosphere models (TBMs), we suggest that within the current modeling framework, calculations of net ecosystem production (NEP) defined as terrestrial only may be overestimated by as much as 27%. However, the internal production and mineralization of carbon in freshwaters remain to be quantified and would reduce the effect of including aquatic carbon fluxes within calculations of terrestrial NEP. Reconciliation of carbon mass–flux interactions between terrestrial and aquatic carbon sources and sinks will require significant additional research and modeling capacity. PMID:26699473

  6. Cobalamin analogues in humans

    DEFF Research Database (Denmark)

    Hardlei, Tore Forsingdal; Obeid, Rima; Herrmann, Wolfgang

    2013-01-01

    BACKGROUND: Haptocorrin (HC) carries cobalamin analogues (CorA), but whether CorA are produced in the body is unknown. All cobalamins (Cbl) to the foetus are delivered by the Cbl-specific protein transcobalamin (TC), and therefore analysis of cord serum for CorA may help to clarify the origin...

  7. Anthropogenic transformation of the terrestrial biosphere.

    Science.gov (United States)

    Ellis, Erle C

    2011-03-13

    Human populations and their use of land have transformed most of the terrestrial biosphere into anthropogenic biomes (anthromes), causing a variety of novel ecological patterns and processes to emerge. To assess whether human populations and their use of land have directly altered the terrestrial biosphere sufficiently to indicate that the Earth system has entered a new geological epoch, spatially explicit global estimates of human populations and their use of land were analysed across the Holocene for their potential to induce irreversible novel transformation of the terrestrial biosphere. Human alteration of the terrestrial biosphere has been significant for more than 8000 years. However, only in the past century has the majority of the terrestrial biosphere been transformed into intensively used anthromes with predominantly novel anthropogenic ecological processes. At present, even were human populations to decline substantially or use of land become far more efficient, the current global extent, duration, type and intensity of human transformation of ecosystems have already irreversibly altered the terrestrial biosphere at levels sufficient to leave an unambiguous geological record differing substantially from that of the Holocene or any prior epoch. It remains to be seen whether the anthropogenic biosphere will be sustained and continue to evolve.

  8. Concise synthesis of new bridged-nicotine analogues

    DEFF Research Database (Denmark)

    Crestey, François; Hooyberghs, Geert; Kristensen, Jesper Langgaard

    2012-01-01

    This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively.......This study describes a very efficient strategy for the synthesis of two new bridged-nicotine analogues. Starting from either 4- or 3-chloropyridine the desired tricyclic ring systems are accessed in just three steps in 23% and 40% overall yield, respectively....

  9. Deficiencies in fat-soluble vitamins in long-term users of somatostatin analogue

    NARCIS (Netherlands)

    Fiebrich, H. -B.; van den Berg, G.; Kema, I. P.; Links, T. P.; Kleibeuker, J. H.; van Beek, A. P.; Walenkamp, A. M. E.; Sluiter, W. J.; de Vries, E. G. E.

    2010-01-01

    P>Background Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. Somatostatin analogues can increase fat in the stools, which can lead to loss of fat-soluble vitamins. The effect of long-term somatostatin analogue use on vitamin levels

  10. Climate Analogues for agricultural impact projection and adaptation – a reliability test

    Directory of Open Access Journals (Sweden)

    Swen P.M. Bos

    2015-10-01

    Full Text Available The climate analogue approach is often considered a valuable tool for climate change impact projection and adaptation planning, especially for complex systems that cannot be modelled reliably. Important examples are smallholder farming systems using agroforestry or other mixed-cropping approaches. For the projected climate at a particular site of interest, the analogue approach identifies locations where the current climate is similar to these projected conditions. By comparing baseline-analogue site pairs, information on climate impacts and opportunities for adaptation can be obtained. However, the climate analogue approach is only meaningful, if climate is a dominant driver of differences between baseline and analogue site pairs. For a smallholder farming setting on Mt. Elgon in Kenya, we tested this requirement by comparing yield potentials of maize and coffee (obtained from the IIASA Global Agro-ecological Zones dataset among 50 close analogue sites for different future climate scenarios and models, and by comparing local ecological knowledge and farm characteristics for one baseline-analogue pair.Yield potentials among the 50 closest analogue locations varied strongly within all climate scenarios, hinting at factors other than climate as major drivers of what the analogue approach might interpret as climate effects. However, on average future climatic conditions seemed more favourable to maize and coffee cultivation than current conditions. The detailed site comparison revealed substantial differences between farms in important characteristics, such as farm size and presence of cash crops, casting doubt on the usefulness of the comparison for climate change analysis. Climatic constraints were similar between sites, so that no apparent lessons for adaptation could be derived. Pests and diseases were also similar, indicating that climate change may not lead to strong changes in biotic constraints at the baseline site in the near future. From

  11. Histories of terrestrial planets

    International Nuclear Information System (INIS)

    Benes, K.

    1981-01-01

    The uneven historical development of terrestrial planets - Mercury, Venus, Earth, Moon and Mars - is probably due to the differences in their size, weight and rotational dynamics in association with the internal planet structure, their distance from the Sun, etc. A systematic study of extraterrestrial planets showed that the time span of internal activity was not the same for all bodies. It is assumed that the initial history of all terrestrial planets was marked with catastrophic events connected with the overall dynamic development of the solar system. In view of the fact that the cores of small terrestrial bodies cooled quicker, their geological development almost stagnated after two or three thousand million years. This is what probably happened to the Mercury and the Moon as well as the Mars. Therefore, traces of previous catastrophic events were preserved on the surface of the planets. On the other hand, the Earth is the most metamorphosed terrestrial planet and compared to the other planets appears to be atypical. Its biosphere is significantly developed as well as the other shell components, its hydrosphere and atmosphere, and its crust is considerably differentiated. (J.P.)

  12. Terrestrial service environments for selected geographic locations. Final report. [1965--1974 data; to define solar array environment to aid in encapsulation program

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, R.E.; Carmichael, D.C.

    1976-06-24

    This report contains results obtained from analyses of climatic, precipitation, air pollution, and other environmental data for the years 1965 to 1974 at nine widely different geographic locations in the United States (Albuquerque, N.M.; Bismarck, N.D.; Boston, Mass.; Brownsville, TX.; Cleveland, OH; Fairbanks, AK; Los Angeles, CA; Miami, FL; and Phoenix, AZ). In addition to descriptive and diurnal statistics for 24 individual climatic variables, ''environmental cell'' statistics were computed to obtain the frequencies, durations, and transitions for the simultaneous occurrence of various combinations of environmental variables. Results are presented for the simultaneous occurrence of specific levels of air temperature, relative humidity, wind speed, and insolation, in addition to representative results obtained for other combinations of variables. The results characterize the environmental conditions to which terrestrial solar arrays would be exposed over a 20-year lifetime, and serve to identify environmental factors and levels that can be used in testing candidate encapsulation materials and systems for such terrestrial exposures. An innovative methodology was applied to obtain these results for combinations of environmental variables. Because of its generality and demonstrated feasibility, it is concluded that the methodology also has broad applications to other testing programs.

  13. The costal landslide from analogue experiments: perspectives and limitation

    Science.gov (United States)

    Del Ventisette, C.; Nolesini, T.; Moretti, S.; Fanti, R.

    2010-12-01

    varing between 35° and 25°, depending on whether the simulated environment is subaerial or submarine, according to the inclination Average Sciara del Fuoco (Boldini et al. 2005; Chiocci et al., 2008). During models construction several difficulties came out as the difficulties to chose the suitable material for analogue models in the presence of water. Indeed the presence of water causes in the analogue materials a very fast capillary rising. In this work we propose some technical devices to minimize this limitations, such as impermeable barriers. References Boldini D., Wang F. W., Sassa K., Tommasi P., 2005. Mechanism of landslide causing the December 2002 tsunami at Stromboli volcano. Landslide: Risk Analysis and Sustainable Disaster Management, 173-180, Springer, New York. Chiocci F. L., Romagnoli C., Tommasi P., Bosman A., 2008. The Stromboli tsunamigenic submarine slide: Characteristic and possible failure mechanism. Journal of Geophysical research vol. 113, B 10102. Hubbert M.K., 1937. Theory of scale models as applied to the study of geologic structures. Geol. Soc. Am. Bull. 48, 1459-1520. Ramberg H., 1981. Gravity, deformation and the Earth’s crust in theory, experiments and geologic application, 2nd Edition. Academic, London, pp 1-452.

  14. Nanomaterials in the Environment: Perspectives on in Vivo Terrestrial Toxicity Testing

    Directory of Open Access Journals (Sweden)

    Monique C. P. Mendonça

    2017-10-01

    Full Text Available Over the last decade, engineered nanomaterials (NMs brought a revolutionary development in many sectors of human life including electronics, paints, textiles, food, agriculture, and health care. However, the exponential growth in the number of NMs applications resulted in uncertainties regarding their environmental impacts. Currently, the common approach for assessing the toxicity of NMs such as, carbon—(fullerenes, single- and multi-walled carbon nanotubes, mineral—(gold and silver nanoparticles, cerium and zinc oxide, silicon and titanium dioxide, and organic-based NMs (dendrimers includes standard guidelines applied to all chemical compounds. Nevertheless, NMs differ from traditional materials as their physicochemical and surface properties influence the toxic rather than their composition alone. Considering such NMs specificities, adaptations in some methods are necessary to ensure that environmental and human health risks are accurately investigated. In this context, the focus of this mini-review is to summarize the current knowledge in nanotoxicology regarding relevant organisms and experimental assays for assessing the terrestrial toxicity of NMs.

  15. Biotic survival in the cryobiosphere on geological scale: implication for astro/terrestrial biogeoscience

    Science.gov (United States)

    Gilichinsky, D.

    2003-04-01

    In current opinion the most fundamental aspect of any environment, the temperature regime, acts as a regulator of all of the physical-chemical reactions and forms the basis of all biological processes. Now hard data indicate the biotic survival over geological periods from subzero temperatures (down to -27oC in permafrost and to -50oC in ice) to positive one in amber and halite. All these very different environments have, nevertheless, common features: complete isolation, stability and waterproof. In such unique physical-chemical complexes, the dehydration of macromolecules and the reorganization of membrane components apparently lead to a considerable decrease or stop of metabolic activity independently of temperature. This allowed the prolonged survival of ancient microbial lineage that realize unknown possibilities of physiological and biochemical adaptation incomparably longer than any other known habitat. The ability of microorganisms to survive on geological scale within the broad limits of natural systems forces us to redefine the spatial and temporal limits of the terrestrial and extraterrestrial biospheres and suggested that universal mechanisms of such adaptation might operate for millions of years. Among new scientific directions formed on this base, the most general is the fundamental question: how long the life might be preserved and what mechanisms could ensure survival? Because the length of lifetime cannot be reproduced, this highlights the natural storages that make possible the observation of the results of biotic survival on geological scale. Of special interest is the interaction of knowledge to understanding of the limits of the deep cold biosphere as a depository of ancient active biosignatures (biogases, biominerals, pigments, lipids, enzymes, proteins, RNA/DNA fragments) and viable cells. The last are the only known a huge mass of organisms that have retained viability over geological periods and upon thawing, renew physiological activity

  16. Analogue Electrical Circuit for Simulation of the Duffing-Holmes Equation

    DEFF Research Database (Denmark)

    Tamaseviciute, E.; Tamasevicius, A.; Mykolaitis, G.

    2008-01-01

    An extremely simple second order analogue electrical circuit for simulating the two-well Duffing-Holmes mathematical oscillator is described. Numerical results and analogue electrical simulations are illustrated with the snapshots of chaotic waveforms, phase portraits (Lissajous figures...

  17. 3-alkyl fentanyl analogues: Structure-activity-relationship study

    OpenAIRE

    Vučković, Sonja; Savić-Vujović, Katarina; Srebro, Dragana; Ivanović, Milovan; Došen-Mićović, Ljiljana; Stojanović, Radan; Prostran, Milica

    2012-01-01

    Introduction. Fentanyl belongs to 4-anilidopiperidine class of synthetic opioid analgesics. It is characterized by high potency, rapid onset and short duration of action. A large number of fentanyl analogues have been synthesized so far, both to establish the structure-activity-relationship (SAR) and to find novel, clinically useful analgesic drugs. Objective. In this study, newly synthesized 3-alkyl fentanyl analogues were examined for analgesic activity and compared with fentanyl. Methods. ...

  18. Rheological and physical characteristics of crustal-scaled materials for centrifuge analogue modelling

    Science.gov (United States)

    Waffle, Lindsay; Godin, Laurent; Harris, Lyal B.; Kontopoulou, M.

    2016-05-01

    We characterize a set of analogue materials used for centrifuge analogue modelling simulating deformation at different levels in the crust simultaneously. Specifically, we improve the rheological characterization in the linear viscoelastic region of materials for the lower and middle crust, and cohesive synthetic sands without petroleum-binding agents for the upper crust. Viscoelastic materials used in centrifuge analogue modelling demonstrate complex dynamic behaviour, so viscosity alone is insufficient to determine if a material will be an effective analogue. Two series of experiments were conducted using an oscillating bi-conical plate rheometer to measure the storage and loss moduli and complex viscosities of several modelling clays and silicone putties. Tested materials exhibited viscoelastic and shear-thinning behaviour. The silicone putties and some modelling clays demonstrated viscous-dominant behaviour and reached Newtonian plateaus at strain rates clays demonstrated elastic-dominant power-law relationships. Based on these results, the elastic-dominant modelling clay is recommended as an analogue for basement cratons. Inherently cohesive synthetic sands produce fine-detailed fault and fracture patterns, and developed thrust, strike-slip, and extensional faults in simple centrifuge test models. These synthetic sands are recommended as analogues for the brittle upper crust. These new results increase the accuracy of scaling analogue models to prototype. Additionally, with the characterization of three new materials, we propose a complete lithospheric profile of analogue materials for centrifuge modelling, allowing future studies to replicate a broader range of crustal deformation behaviours.

  19. Sensitivity of Coastal Environments and Wildlife to Spilled Oil: Upper Coast of Texas: T_MAMMAL (Terrestrial Mammal Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for terrestrial mammals for the Upper Coast of Texas. Vector polygons in this data set represent...

  20. Progress towards the Conventionon Biological Diversity terrestrial2010 and marine 2012 targets forprotected area coverage

    DEFF Research Database (Denmark)

    Coad, Lauren; Burgess, Neil David; Fish, Lucy

    2010-01-01

    coverage targets. National protected areas data from the WDPA have been used to measure progress in protected areas coverage at global, regional and national scale. The mean protected area coverage per nation was 12.2% for terrestrial area, and only 5.1% for near-shore marine area. Variation in protected......Protected area coverage targets set by the Convention on Biological Diversity (CBD) for both terrestrial and marine environments provide a major incentive for governments to review and upgrade their protected area systems. Assessing progress towards these targets will form an important component...... of the work of the Xth CBD Conference of Parties meeting to be held in Japan in 2010. The World Database on Protected Areas (WDPA) is the largest assembly of data on the world's terrestrial and marine protected areas and, as such, represents a fundamental tool in tracking progress towards protected area...

  1. Labelling and evaluation of new stabilised neurotensin (8-13) analogues for SPET

    International Nuclear Information System (INIS)

    Chavatte, K.; Terriere, D.; Jeannin, L.

    1998-01-01

    Neurotensin (8-13) analogues were biologically stabilised by replacement of the peptide bond between amino acids 8 and 9 by the reduced ψ(CH 2 -NH) isostere. DTPA analogues for In-111 labelling and 2-bromo-phenyl-acetyl analogues for radioiodination, showed receptor affinities in the low nanomolar range in combination with a biological half live in human plasma up to 275 minutes. Biodistribution studies in male Wistar rats of metabolically stabilised and non-stabilised 111 In-DTPA-NT(8-13) analogues showed a major clearance from the blood through the kidneys. 125 I-labelled Neurotensin (8-13) analogues showed accumulation up to 2.2% of the injected dose per g tissue in the liver which might be an important disadvantage when diagnosis of tumours in the gut is aimed. It is strongly suggested that stabilised neurotensin (8-13) analogues whether labelled with In-111, I-123 and the near future with Tc-99m, may act as new potential peptidergic radiopharmaceuticals for SPET diagnosis of different NT-receptor positive tumours like non-endocrine pancreas carcinoma, small cell lung carcinoma or colon adeno carcinoma. It is enticing to speculate that metabolically stabilised Neurotensin (8-13) analogues labelled with an appropriate isotope might be useful in therapy of different human cancers. (author)

  2. Long-term exposure of /sup 238/PuO/sub 2/ to a terrestrial environment. Volume III

    Energy Technology Data Exchange (ETDEWEB)

    Heaton, R.C.; Patterson, J.H.; Steinkruger, F.J.; Coffelt, K.P.

    1985-02-01

    A plutonium oxide source consisting of a single piece of 83% /sup 238/PuO/sub 2/ and weighing 38 g was exposed for 2.9 years to a humid, temperate terrestrial environment in an environmental simulation chamber. The soil tray of the chamber was divided into four compartments so that different soil types could be studied under identical conditions. Soils examined in this experiment included loam, silt loam, sand, and humus. Plutonium released into the soils, the soil drainages, and the condensates from the dehumidifier was monitored throughout the experiment. The total plutonium release rate from the PuO/sub 2/ source was approximately 2 ng/m/sup 2//s. The generation of short-ranged airborne plutonium, able to travel from a few centimeters to half a meter, was one of the most significant release pathways. The amount of plutonium released in this way was 10 times that washed directly off the source by rainwater and 20 times that from the fully airborne (longer ranged) release. Of the 200 ..mu..g of plutonium deposited in the soils, less than 0.1 ..mu..g was released into the soil percolates. In fact, the soil percolates constituted the least significant release pathway. Within the uncertainties in deriving the plutonium inventories of the soil compartments, we found no discernible differences among the behaviors of the four soil types towards plutonium. There was little or no seasonal effect on the release of plutonium from the soil.

  3. Thymidine analogues to assess microperfusion in human tumors

    International Nuclear Information System (INIS)

    Janssen, Hilde L.; Ljungkvist, Anna S.; Rijken, Paul F.; Sprong, Debbie; Bussink, Jan; Kogel, Albert J. van der; Haustermans, Karin M.; Begg, Adrian C.

    2005-01-01

    Purpose: To validate the use of the thymidine analogues as local perfusion markers in human tumors (no labeling indicates no perfusion) by comparison with the well-characterized perfusion marker Hoechst 33342. Methods and Materials: Human tumor xenografts from gliomas and head-and-neck cancers were injected with iododeoxyuridine (IdUrd) or bromodeoxyuridine (BrdUrd) and the fluorescent dye Hoechst 33342. In frozen sections, each blood vessel was scored for the presence of IdUrd/BrdUrd labeling and Hoechst in surrounding cells. The percentage of analogue-negative vessels was compared with the fraction of Hoechst-negative vessels. Collocalization of the two markers was also scored. Results: We found considerable intertumor variation in the fraction of perfused vessels, measured by analogue labeling, both in the human tumor xenografts and in a series of tumor biopsies from head-and-neck cancer patients. There was a significant correlation between the Hoechst-negative and IdUrd/BrdUrd-negative vessels in the xenografts (r 85, p = 0.0004), despite some mismatches on a per-vessel basis. Conclusions: Thymidine analogues can be successfully used to rank tumors according to their fraction of perfused vessels. Whether this fraction correlates with the extent of acute hypoxia needs further confirmation

  4. Analogues of estradiol as potential breast tumor imaging agents

    International Nuclear Information System (INIS)

    Gibson, R.E.; Rzeszotarski, W.J.; Ferriera, N.L.; Jagoda, E.M.; Reba, R.C.; Eckelman, W.C.

    1984-01-01

    The radioiodinated analogue of estradiol, 11β-methoxy-17α-[/sup 125/I]iodovinylestradiol (MIVE/sub 2/), has been shown to be a good candidate for the imaging of estrogen dependent breast tumors. Although there has been no extensive study on the sensitivity of radiotracers of this type, the authors have not observed localization of the radiotracer in metastatic lesions containing less than 20 fmole estrogen receptor/mg protein or in bone metasteses. In order to improve the sensitivity, they have examined several structural analogues of moxestrol (the parent structure for MIVE/sub 2/) for affinity to the ER isolated from immature rat uterus. The 11β-ethyl analogue (EEE/sub 2/) of ethynyl estradiol (EE/sub 2/) exhibits the highest affinity with the 11β-methyl analogue second best. Although the lipophilicity is also very high this compound should not be much more lipophilic than 16-iodoestradiol or MIVE/sub 2/ since the introduction of iodine increases the log P by greater than 1. The distribution of the tritiated derivative of EEE/sub 2/ is under study

  5. The Global Environment: At a Tipping Point?

    OpenAIRE

    Han, Xueying; Appelbaum, Richard

    2014-01-01

    Overview of the current global environment. Introduction to climate change, global warming, ocean warming and acidification, impacts on both aquatic and terrestrial ecosystems. Lecture used for a Global Studies class.

  6. An isotopic investigation of mercury accumulation in terrestrial food webs adjacent to an Arctic seabird colony

    International Nuclear Information System (INIS)

    Choy, Emily S.; Gauthier, Martine; Mallory, Mark L.; Smol, John P.; Douglas, Marianne S.V.; Lean, David; Blais, Jules M.

    2010-01-01

    At Cape Vera (Devon Island, Nunavut, Canada), a seabird colony of northern fulmars (Fulmarus glacialis) congregates and releases nutrients through the deposition of guano to the coastal terrestrial environment, thus creating nutrient-fertilized habitats important to insects, birds, and mammals. Here we determined whether mercury was similarly enriched in various terrestrial food web components in this High Arctic coastal ecosystem due to seabird inputs. Stable isotopes (δ 15 N, δ 13 C) were used to identify trophic linkages and possible routes of contaminant transfer in the food web. Values of δ 15 N were significantly higher in lichens and certain plants collected closer to the bird colony, demonstrating a gradient of seabird influence, and were higher at Cape Vera than our reference site at Cape Herschel, on eastern Ellesmere Island, an area relatively unaffected by seabirds. In contrast, δ 13 C showed little variation among terrestrial species, suggesting minimal influence by seabirds. Concentrations of total mercury (THg) in primary producers and phyto/zooplankton were not significantly correlated with distance from the seabird colony or δ 15 N values, and were similar to other taxa from the High Arctic. Our results provide novel data on THg in several Arctic taxa where concentrations have not been reported previously. Moreover, the analyses indicate that δ 15 N is significantly enriched in the adjacent environment by guano fertilization, but our study was unable to show an enrichment of THg and δ 13 C in the terrestrial food web near the seabird colony.

  7. Iodination and stability of somatostatin analogues: comparison of iodination techniques. A practical overview.

    Science.gov (United States)

    de Blois, Erik; Chan, Ho Sze; Breeman, Wouter A P

    2012-01-01

    For iodination ((125/127)I) of tyrosine-containing peptides, chloramin-T, Pre-Coated Iodo-Gen(®) tubes and Iodo-Beads(®) (Pierce) are commonly used for in vitro radioligand investigations and there have been reliant vendors hereof for decades. However, commercial availability of these radio-iodinated peptides is decreasing. For continuation of our research in this field we investigated and optimized (radio-)iodination of somatostatin analogues. In literature, radioiodination using here described somatostatin analogues and iodination techniques are described separately. Here we present an overview, including High Performance Liquid Chromatography (HPLC) separation and characterisation by mass spectrometry, to obtain mono- and di-iodinated analogues. Reaction kinetics of (125/127)I iodinated somatostatin analogues were investigated as function of reaction time and concentration of reactants, including somatostatin analogues, iodine and oxidizing agent. To our knowledge, for the here described somatostatin analogues, no (127)I iodination and optimization are described. (Radio-)iodinated somatostatin analogues could be preserved with a >90% radiochemical purity for 1 month after reversed phase HPLC-purification.

  8. Natural analogues of nuclear waste glass corrosion

    International Nuclear Information System (INIS)

    Abrajano, T.A. Jr.; Ebert, W.L.; Luo, J.S.

    1999-01-01

    This report reviews and summarizes studies performed to characterize the products and processes involved in the corrosion of natural glasses. Studies are also reviewed and evaluated on how well the corrosion of natural glasses in natural environments serves as an analogue for the corrosion of high-level radioactive waste glasses in an engineered geologic disposal system. A wide range of natural and experimental corrosion studies has been performed on three major groups of natural glasses: tektite, obsidian, and basalt. Studies of the corrosion of natural glass attempt to characterize both the nature of alteration products and the reaction kinetics. Information available on natural glass was then compared to corresponding information on the corrosion of nuclear waste glasses, specifically to resolve two key questions: (1) whether one or more natural glasses behave similarly to nuclear waste glasses in laboratory tests, and (2) how these similarities can be used to support projections of the long-term corrosion of nuclear waste glasses. The corrosion behavior of basaltic glasses was most similar to that of nuclear waste glasses, but the corrosion of tektite and obsidian glasses involves certain processes that also occur during the corrosion of nuclear waste glasses. The reactions and processes that control basalt glass dissolution are similar to those that are important in nuclear waste glass dissolution. The key reaction of the overall corrosion mechanism is network hydrolysis, which eventually breaks down the glass network structure that remains after the initial ion-exchange and diffusion processes. This review also highlights some unresolved issues related to the application of an analogue approach to predicting long-term behavior of nuclear waste glass corrosion, such as discrepancies between experimental and field-based estimates of kinetic parameters for basaltic glasses

  9. Natural analogues of nuclear waste glass corrosion.

    Energy Technology Data Exchange (ETDEWEB)

    Abrajano, T.A. Jr.; Ebert, W.L.; Luo, J.S.

    1999-01-06

    This report reviews and summarizes studies performed to characterize the products and processes involved in the corrosion of natural glasses. Studies are also reviewed and evaluated on how well the corrosion of natural glasses in natural environments serves as an analogue for the corrosion of high-level radioactive waste glasses in an engineered geologic disposal system. A wide range of natural and experimental corrosion studies has been performed on three major groups of natural glasses: tektite, obsidian, and basalt. Studies of the corrosion of natural glass attempt to characterize both the nature of alteration products and the reaction kinetics. Information available on natural glass was then compared to corresponding information on the corrosion of nuclear waste glasses, specifically to resolve two key questions: (1) whether one or more natural glasses behave similarly to nuclear waste glasses in laboratory tests, and (2) how these similarities can be used to support projections of the long-term corrosion of nuclear waste glasses. The corrosion behavior of basaltic glasses was most similar to that of nuclear waste glasses, but the corrosion of tektite and obsidian glasses involves certain processes that also occur during the corrosion of nuclear waste glasses. The reactions and processes that control basalt glass dissolution are similar to those that are important in nuclear waste glass dissolution. The key reaction of the overall corrosion mechanism is network hydrolysis, which eventually breaks down the glass network structure that remains after the initial ion-exchange and diffusion processes. This review also highlights some unresolved issues related to the application of an analogue approach to predicting long-term behavior of nuclear waste glass corrosion, such as discrepancies between experimental and field-based estimates of kinetic parameters for basaltic glasses.

  10. Terrestrial Steering Group. 2014. Arctic Terrestrial Biodiversity Monitoring Plan

    DEFF Research Database (Denmark)

    Aastrup, Peter; Aronsson, Mora; Barry, Tom

    capacity and information may be currently available and (b) to outline near-term required steps to begin implementing the plan and reporting on an initial set of Arctic terrestrial biodiversity focal ecosystem component attributes. The specific objectives of the workshop were to: Identify key products...... for TSG for the next two years. Identify key components of a pan-Arctic status report for priority focal ecosystem components (FEC) attributes for policy and decision makers. Develop a prioritized set of activities to meet reporting objectives. Identify key milestones and timelines for the successful...... implementation of the Arctic Terrestrial Biodiversity Monitoring Plan for the next two years. Identify expert networks required for successful implementation of the plan. Identify key gaps and opportunities for the TSG related to plan implementation and identify near-term next steps to address gaps....

  11. Lunar and Planetary Science XXXV: Mars: Remote Sensing and Terrestrial Analogs

    Science.gov (United States)

    2004-01-01

    The session "Mars: Remote Sensing and Terrestrial Analogs" included the following:Physical Meaning of the Hapke Parameter for Macroscopic Roughness: Experimental Determination for Planetary Regolith Surface Analogs and Numerical Approach; Near-Infrared Spectra of Martian Pyroxene Separates: First Results from Mars Spectroscopy Consortium; Anomalous Spectra of High-Ca Pyroxenes: Correlation Between Ir and M ssbauer Patterns; THEMIS-IR Emissivity Spectrum of a Large Dark Streak near Olympus Mons; Geomorphologic/Thermophysical Mapping of the Athabasca Region, Mars, Using THEMIS Infrared Imaging; Mars Thermal Inertia from THEMIS Data; Multispectral Analysis Methods for Mapping Aqueous Mineral Depostis in Proposed Paleolake Basins on Mars Using THEMIS Data; Joint Analysis of Mars Odyssey THEMIS Visible and Infrared Images: A Magic Airbrush for Qualitative and Quantitative Morphology; Analysis of Mars Thermal Emission Spectrometer Data Using Large Mineral Reference Libraries ; Negative Abundance : A Problem in Compositional Modeling of Hyperspectral Images; Mars-LAB: First Remote Sensing Data of Mineralogy Exposed at Small Mars-Analog Craters, Nevada Test Site; A Tool for the 2003 Rover Mini-TES: Downwelling Radiance Compensation Using Integrated Line-Sight Sky Measurements; Learning About Mars Geology Using Thermal Infrared Spectral Imaging: Orbiter and Rover Perspectives; Classifying Terrestrial Volcanic Alteration Processes and Defining Alteration Processes they Represent on Mars; Cemented Volcanic Soils, Martian Spectra and Implications for the Martian Climate; Palagonitic Mars: A Basalt Centric View of Surface Composition and Aqueous Alteration; Combining a Non Linear Unmixing Model and the Tetracorder Algorithm: Application to the ISM Dataset; Spectral Reflectance Properties of Some Basaltic Weathering Products; Morphometric LIDAR Analysis of Amboy Crater, California: Application to MOLA Analysis of Analog Features on Mars; Airborne Radar Study of Soil Moisture at

  12. Asia-MIP: Multi Model-data Synthesis of Terrestrial Carbon Cycles in Asia

    Science.gov (United States)

    Ichii, K.; Kondo, M.; Ito, A.; Kang, M.; Sasai, T.; SATO, H.; Ueyama, M.; Kobayashi, H.; Saigusa, N.; Kim, J.

    2013-12-01

    Asia, which is characterized by monsoon climate and intense human activities, is one of the prominent understudied regions in terms of terrestrial carbon budgets and mechanisms of carbon exchange. To better understand terrestrial carbon cycle in Asia, we initiated multi-model and data intercomparison project in Asia (Asia-MIP). We analyzed outputs from multiple approaches: satellite-based observations (AVHRR and MODIS) and related products, empirically upscaled estimations (Support Vector Regression) using eddy-covariance observation network in Asia (AsiaFlux, CarboEastAsia, FLUXNET), ~10 terrestrial biosphere models (e.g. BEAMS, Biome-BGC, LPJ, SEIB-DGVM, TRIFFID, VISIT models), and atmospheric inversion analysis (e.g. TransCom models). We focused on the two difference temporal coverage: long-term (30 years; 1982-2011) and decadal (10 years; 2001-2010; data intensive period) scales. The regions of covering Siberia, Far East Asia, East Asia, Southeast Asia and South Asia (60-80E, 10S-80N), was analyzed in this study for assessing the magnitudes, interannual variability, and key driving factors of carbon cycles. We will report the progress of synthesis effort to quantify terrestrial carbon budget in Asia. First, we analyzed the recent trends in Gross Primary Productivities (GPP) using satellite-based observation (AVHRR) and multiple terrestrial biosphere models. We found both model outputs and satellite-based observation consistently show an increasing trend in GPP in most of the regions in Asia. Mechanisms of the GPP increase were analyzed using models, and changes in temperature and precipitation play dominant roles in GPP increase in boreal and temperate regions, whereas changes in atmospheric CO2 and precipitation are important in tropical regions. However, their relative contributions were different. Second, in the decadal analysis (2001-2010), we found that the negative GPP and carbon uptake anomalies in 2003 summer in Far East Asia is one of the largest

  13. Polonium-210 and lead-210 in the terrestrial environment: a historical review

    Energy Technology Data Exchange (ETDEWEB)

    Persson, Bertil R.R., E-mail: bertil_r.persson@med.lu.s [Dept. of Medical Radiation Physics, Lund University, Barngatan 2, SE-221 85 Lund (Sweden); Holm, Elis [Norwegian Radiation Protection Authority, Osteras (Norway)

    2011-05-15

    The radionuclides {sup 210}Po and {sup 210}Pb widely present in the terrestrial environment are the final long-lived radionuclides in the decay of {sup 238}U in the earth's crust. Their presence in the atmosphere is due to the decay of {sup 222}Rn diffusing from the ground. The range of activity concentrations in ground level air for {sup 210}Po is 0.03-0.3 Bq m{sup -3} and for {sup 210}Pb 0.2-1.5 Bq m{sup -3}. In drinking water from private wells the activity concentration of {sup 210}Po is in the order of 7-48 mBq l{sup -1} and for {sup 210}Pb around 11-40 mBq l{sup -1}. From water works, however, the activity concentration for both {sup 210}Po and {sup 210}Pb is only in the order of 3 mBq l{sup -1}. Mosses, lichens and peat have a high efficiency in capturing {sup 210}Po and {sup 210}Pb from atmospheric fallout and exhibit an inventory of both {sup 210}Po and {sup 210}Pb in the order of 0.5-5 kBq m{sup -2} in mosses and in lichens around 0.6 kBq m{sup -2}. The activity concentrations in lichens lies around 250 Bq kg{sup -1}, dry mass. Reindeer and caribou graze lichen which results in an activity concentration of {sup 210}Po and {sup 210}Pb of about 1-15 Bq kg{sup -1} in meat from these animals. The food chain lichen-reindeer or caribou, and Man constitutes a unique model for studying the uptake and retention of {sup 210}Po and {sup 210}Pb in humans. The effective annual dose due to {sup 210}Po and {sup 210}Pb in people with high consumption of reindeer/caribou meat is estimated to be around 260 and 132 {mu}Sv a{sup -1} respectively. In soils, {sup 210}Po is adsorbed to clay and organic colloids and the activity concentration varies with soil type and also correlates with the amount of atmospheric precipitation. The average activity concentration levels of {sup 210}Po in various soils are in the range of 20-240 Bq kg{sup -1}. Plants become contaminated with radioactive nuclides both by absorption from the soil (supported Po) and by deposition of radioactive

  14. From BPA to its analogues: Is it a safe journey?

    Science.gov (United States)

    Usman, Afia; Ahmad, Masood

    2016-09-01

    Bisphenol-A (BPA) is one of the most abundant synthetic chemicals in the world due to its uses in plastics. Its widespread exposure vis-a-vis low dose effects led to a reduction in its safety dose and imposition of ban on its use in infant feeding bottles. This restriction paved the way for the gradual market entry of its analogues. However, their structural similarity to BPA has put them under surveillance for endocrine disrupting potential. The application of these analogues is increasing and so are the studies reporting their toxicity. This review highlights the reasons which led to the ban of BPA and also reports the exposure and toxicological data available on its analogues. Hence, this compilation is expected to answer in a better way whether the replacement of BPA by these analogues is safer or more harmful? Copyright © 2016. Published by Elsevier Ltd.

  15. Synthesis of the available information about the radioactive contamination of the Japanese terrestrial environment caused by the Fukushima Dai-ichi accident - May 25, 2011

    International Nuclear Information System (INIS)

    2011-01-01

    The French institute of radiation protection and nuclear safety (IRSN) collects and analyses regularly the published data concerning the contamination of the Japanese terrestrial environment caused by the Fukushima Dai-ichi power plant accident. This synthesis presents a status of the data recently obtained since the previous similar note of April 12. The note presents a mapping of 137 Cs and 134 Cs cumulated deposits in a 80 km area around the damaged power plant, an estimation of the cumulated atmospheric precipitations during March 15-16 night, the evolution of the gamma dose rates in the ambient air of several towns of the Fukushima district, the evolution of the 134 Cs+ 137 Cs and 131 I contamination of agriculture food products and of surface and drinking waters. (J.S.)

  16. Design of a saturated analogue and digital current transducer

    International Nuclear Information System (INIS)

    Pross, Alexander

    2002-01-01

    This project describes the development of a new analogue and digital current transducer, providing a range of new theoretical design methods for these novel devices. The main control feature is the limit cycling operation, and the novel use of the embedded sigma-delta modulator sensor structure to derive a low component count digital sensor. The research programme was initiated into the design, development and evaluation of a novel non-Hall sensing analogue and digital current transducer. These transducers are used for measurement of high currents in power systems applications. The investigation is concerned with a new design which uses a magnetic ferrite core without an air gap for current measurement. The motivation for this work was to design a new control circuit which provides a low component count, and utilises the non-linear properties of the magnetic ferrite core to transmit direct current. The use of a limit cycle control circuit was believed to be particularly suitable for the analogue and digital transducers, for two main reasons: the low component count, and the output signal is directly digital. In line with the motivations outlined above, the outcome of the research has witnessed the design, development and evaluation of a practically realisable analogue and digital current transducer. The design procedure, which is documented in this thesis, is considered to be a major contribution to the field of transducers design and development using a control systems approach. Mathematical models for both analogue and digital transducers were developed and the resulting model based predictions were found to be in good agreement with measured results. Simplification of the new model sensing device was achieved by approximating the non-linear ferrite core using FFT analysis. This is also considered to be a significant contribution. The development analogue and digital current censors employed a sampled data control systems design and utilised limit cycling

  17. Terrestrial ecosystems and biodiversity

    CSIR Research Space (South Africa)

    Davis-Reddy, Claire

    2017-10-01

    Full Text Available Ecoregions Terrestrial Biomes Protected Areas Climate Risk and Vulnerability: A Handbook for Southern Africa | 75 7.2. Non-climatic drivers of ecosystem change 7.2.1. Land-use change, habitat loss and fragmentation Land-use change and landscape... concentrations of endemic plant and animal species, but these mainly occur in areas that are most threatened by human activity. Diverse terrestrial ecosystems in the region include tropical and sub-tropical forests, deserts, savannas, grasslands, mangroves...

  18. The terrestrial ecosystem program for the Yucca Mountain Project

    International Nuclear Information System (INIS)

    Ostler, W.K.; O'Farrell, T.P.

    1994-01-01

    DOE has implemented a program to monitor and mitigate impacts associated with site Characterization Activities at Yucca Mountain on the environment. This program has a sound experimental and statistical base. Monitoring data has been collected for parts of the program since 1989. There have been numerous changes in the Terrestrial Ecosystems Program since 1989 that reflect changes in the design and locations of Site Characterization Activities. There have also been changes made in the mitigation techniques implemented to protect important environmental resources based on results from the research efforts at Yucca Mountain. These changes have strengthened DOE efforts to ensure protection of the environmental during Site Characterization. DOE,has developed and implemented an integrated environmental program that protects the biotic environment and will restore environmental quality at Yucca Mountain

  19. Solid-phase synthesis of new saphenamycin analogues with antimicrobial activity

    DEFF Research Database (Denmark)

    Laursen, Jane B.; de Visser, P.C.; Nielsen, H.K.

    2002-01-01

    in parallel with a series of differently substituted benzoic acid derivatives. Treatment with TFA-CH2Cl2 (5:995) released the expected saphenamycin analogues into solution. These new analogues were purified, characterized and screened for antimicrobial activity against Bacillus subtilis and Proteus mirabilis...

  20. Natural analogues for containment-providing barriers for a HLW repository in salt

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, J.; Noseck, U.

    2015-06-15

    In 2005, a German research project was started to develop a novel approach to prove safety for a HLW repository in a salt formation, to refine the safety concept, to identify open scientific issues and to define necessary R&D work. This project aimed at identifying the key information for a HLW repository in salt. One important question is how this information may be best fulfilled by natural analogue studies. This question is answered by starting a review of the required key information needs of the safety case (post-closure phase) in order to assess whether or not these requirements can be supported by natural analogues information. In order to structure the review and to address the key elements of the safety concepts, three types of natural analogues are distinguished: (i) natural analogues for the integrity of the geological barrier, (ii) natural analogues for the integrity of the geotechnical barriers and (iii) natural analogues for release scenarios. For the safety case in salt type (i) and (ii) are of highest importance and are treated in this paper. The assessment documented in this paper on the one hand indicates the high potential benefit of natural analogues for a safety case in salt and on the other hand helps to focus the available human and financial resources for the safety case on the most safety-relevant aspects. (authors)

  1. GnRH Analogues in the Prevention of Ovarian Hyperstimulation Syndrome

    Science.gov (United States)

    Alama, Pilar; Bellver, Jose; Vidal, Carmen; Giles, Juan

    2013-01-01

    The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article. PMID:23825982

  2. Influence of prostaglandin analogues on epithelial cell proliferation and xenograft growth.

    Science.gov (United States)

    Tutton, P J; Barkla, D H

    1980-01-01

    The influence of two prostaglandin (PG) analogues, 16,16-dimethyl PG E2 and 16,16-dimethyl PG F2 alpha and of the cyclo-oxygenase inhibitor, flurbiprofen, on epithelial cell proliferation was assessed using a stathmokinetic technique. The epithelia examined were those of the jejunal crypts, the colonic crypts and that of dimethylhydrazine-induced adenocarcinomas of rat colon. The influence of the two prostaglandin analogues, and of flurbiprofen, on the growth of a human colorectal tumour propagated as xenografts in immune-deprived mice was also assessed. The PG E2 analogue transiently inhibited xenograft growth, but was without effect on the mitotic rate in the rat tissues. The PG F2 alpha analogue was also found to inhibit xenograft growth but, unlike the PG E2 analogue, it was found to be a strong inhibitor of cell proliferation in rat colonic tumours, and an accelerator of proliferation in jejunal-crypt cells. The only statistically significant effect of flurbiprofen was to accelerate cell division in the rat colonic tumours.

  3. Optoelectronic properties of higher acenes, their BN analogue and substituted derivatives

    International Nuclear Information System (INIS)

    Armaković, Stevan; Armaković, Sanja J.; Holodkov, Vladimir; Pelemiš, Svetlana

    2016-01-01

    We have investigated optoelectronic properties of higher acenes: pentacene, hexacene, heptacene, octacene, nonacene, decacene and their boron-nitride (BN) analogues, within the framework of density functional theory (DFT). We have also investigated the optoelectronic properties of acenes modified by BN substitution. Calculated optoelectronic properties encompasses: oxidation and reduction potentials, electron and hole reorganization energies and energy difference between excited first singlet and triplet states ΔE(S_1−T_1). Oxidation and reduction potentials indicate significantly better stability of BN analogues, comparing with their all-carbon relatives. Although higher acenes possess lower electron and hole reorganization energies, with both best values much lower than 0.1 eV, their BN analogues also have competitive values of reorganization energies, especially for holes for which reorganization energy is also lower than 0.1 eV. On the other hand ΔE(S_1−T_1) is much better for BN analogues, having values that indicate that BN analogues are possible applicable for thermally activated delayed fluorescence. - Highlights: • Optoelectronic properties of structures based on higher acenes have been investigated. • Oxidation and reduction potentials together with reorganization energies are calculated. • TADF is analyzed through calculation of ΔE(S_1−T_1), which is much better for BN analogues. • Reorganization energies of acenes improve with the increase of number of benzene rings.

  4. Alligator rivers analogue project. Final report; volume 1; summary of findings

    International Nuclear Information System (INIS)

    Duerden, P.; Lever, D.A.; Sverjensky, D.A.; Townley, L.R.

    1992-01-01

    The Koongarra uranium ore deposit is located in the Alligator Rivers Region of the Northern Territory of Australia. Many of the processes that have controlled the development of this natural system are relevant to the performance assessment of radioactive waste repositories. An agreement was reached in 1987 by a number of agencies concerned with radioactive waste disposal to set up the International Alligator Rivers Analogue Project (ARAP) to study relevant aspects of the hydrological and geochemical evolution of the site. The Project ran for five years. The aims of the study were: to contribute to the production of reliable and realistic models for radionuclide migration within geological environments relevant to the assessment of the safety of radioactive waste repositories; to develop methods of validation of models using a combination of laboratory and field data associated with the Koongarra uranium deposit; and to encourage maximum interaction between modellers and experimentalists in achieving these objectives. It was anticipated that the substantial databases generated in the field and laboratory studies would then be used to develop and test geochemical and radionuclide transport models. The findings from the technical studies are discussed in the context of assessments of the long-term performance of geological repositories for radioactive wastes, which are being undertaken in many countries. They are also considered in an integrated 'Scenario Development' approach, aimed to understand the formation of the ore deposit. Despite their inherent uncertainties, the findings provide a basis for assessing the way in which radionuclides will migrate in environments with a variety of geologic settings and over a range of different geologic timescales. This summary report, which highlights the work and findings of the Alligator Rivers Analogue Project is one of a series of 16 volumes

  5. Terrestrial and extraterrestrial fullerenes

    Energy Technology Data Exchange (ETDEWEB)

    Heymann, D.; Jenneskens, L.W.; Jehlicka, J; Koper, C.; Vlietstra, E. [Rice Univ, Houston, TX (United States). Dept. of Earth Science

    2003-07-01

    This paper reviews reports of occurrences of fullerenes in circumstellar media, interstellar media, meteorites, interplanetary dust particles (IDPs), lunar rocks, hard terrestrial rocks from Shunga (Russia), Sudbury (Canada) and Mitov (Czech Republic), coal, terrestrial sediments from the Cretaceous-Tertiary-Boundary and Pennian-Triassic-Boundary, fulgurite, ink sticks, dinosaur eggs, and a tree char. The occurrences are discussed in the context of known and postulated processes of fullerene formation, including the suggestion that some natural fullerenes might have formed from biological (algal) remains.

  6. Cross-reactivity of amphetamine analogues with Roche Abuscreen radioimmunoassay reagents

    International Nuclear Information System (INIS)

    Cody, J.T.

    1990-01-01

    Cross-reactivity of amphetamine analogues with the Abuscreen amphetamine radioimmunoassay reagents was determined for both the standard and high specificity antibody systems. Compounds tested included 2-methoxyamphetamine, 4-hydroxymethamphetamine, 2,5-dimethoxyamphetamine (DMA), 4-bromo-2,5-dimethoxyamphetamine (DOB), 4-bromo-2,5-dimethoxy-beta-phenethylamine (BDMPEA), 3,4,5-trimethoxyamphetamine (TMA), 3,4-methylenedioxyamphetamine (MDA), N,N-dimethyl-3,4-methylenedioxyamphetamine and N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDEA), 2,5-dimethoxy-4-ethylamphetamine, 2,5-dimethoxy-4-methylamphetamine (DOM), and 3,4,5-trimethoxyphenethylamine (mescaline). Blank negative reference material was spiked with 1,000 to 100,000 ng/mL of the amphetamine analogue and used as sample in the assays. MDA was the only analogue that showed cross reactivity equal to or greater than that of amphetamine. None of the other analogue compounds demonstrated a positive result at even the highest concentration; however several showed depressed counts at various concentration levels

  7. Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues.

    Science.gov (United States)

    Bharate, Sandip B; Bhutani, Kamlesh K; Khan, Shabana I; Tekwani, Babu L; Jacob, Melissa R; Khan, Ikhlas A; Singh, Inder Pal

    2006-03-15

    In the present communication, naturally occurring phloroglucinol-monoterpene adducts, euglobals G1-G4 (3b/a and 4a/b) and 16 new analogues (13a/b-18a/b and 19-22) were synthesized by biomimetic approach. These synthetic compounds differ from natural euglobals in the nature of monoterpene and acyl functionality. All of these compounds were evaluated for their antibacterial, antifungal, antileishmanial and antimalarial activities. Analogue 17b possessed good antibacterial activity against methicillin-resistant Staphylococcus aureus, while analogues 19-22 possessed potent antifungal activity against Candida glabrata with IC50s ranging from 1.5 to 2.5 microg/mL. Euglobals along with all synthesized analogues exhibited antileishmanial activity. Amongst these, euglobal G2 (3a), G3 (4a) and analogues 13a and 14a showed potent antileishmanial activity with IC50s ranging from 2.8 to 3.9 microg/mL. Analogue 16a possessed antimalarial activity against chloroquine sensitive D6 clone of Plasmodium falciparum. None of the compounds showed toxicity against mammalian kidney fibroblasts (vero cells) upto the concentration of 4.76 microg/ml.

  8. 4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl-(2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters

    DEFF Research Database (Denmark)

    Bunch, Lennart; Pickering, Darryl S; Gefflaut, Thierry

    2009-01-01

    this approach has provided important insight into the structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors (iGluRs and mGluRs), as well as the excitatory amino acid transporters (EAATs). In this work, three 4,4-disubstituted Glu analogues 1-3, which are hybrid structures......Subtype-selective ligands are of great interest to the scientific community, as they provide a tool for investigating the function of one receptor or transporter subtype when functioning in its native environment. Several 4-substituted (S)-glutamate (Glu) analogues were synthesized, and altogether...

  9. Parallel Computing for Terrestrial Ecosystem Carbon Modeling

    International Nuclear Information System (INIS)

    Wang, Dali; Post, Wilfred M.; Ricciuto, Daniel M.; Berry, Michael

    2011-01-01

    Terrestrial ecosystems are a primary component of research on global environmental change. Observational and modeling research on terrestrial ecosystems at the global scale, however, has lagged behind their counterparts for oceanic and atmospheric systems, largely because the unique challenges associated with the tremendous diversity and complexity of terrestrial ecosystems. There are 8 major types of terrestrial ecosystem: tropical rain forest, savannas, deserts, temperate grassland, deciduous forest, coniferous forest, tundra, and chaparral. The carbon cycle is an important mechanism in the coupling of terrestrial ecosystems with climate through biological fluxes of CO 2 . The influence of terrestrial ecosystems on atmospheric CO 2 can be modeled via several means at different timescales. Important processes include plant dynamics, change in land use, as well as ecosystem biogeography. Over the past several decades, many terrestrial ecosystem models (see the 'Model developments' section) have been developed to understand the interactions between terrestrial carbon storage and CO 2 concentration in the atmosphere, as well as the consequences of these interactions. Early TECMs generally adapted simple box-flow exchange models, in which photosynthetic CO 2 uptake and respiratory CO 2 release are simulated in an empirical manner with a small number of vegetation and soil carbon pools. Demands on kinds and amount of information required from global TECMs have grown. Recently, along with the rapid development of parallel computing, spatially explicit TECMs with detailed process based representations of carbon dynamics become attractive, because those models can readily incorporate a variety of additional ecosystem processes (such as dispersal, establishment, growth, mortality etc.) and environmental factors (such as landscape position, pest populations, disturbances, resource manipulations, etc.), and provide information to frame policy options for climate change

  10. Earth as a Tool for Astrobiology—A European Perspective

    Science.gov (United States)

    Martins, Zita; Cottin, Hervé; Kotler, Julia Michelle; Carrasco, Nathalie; Cockell, Charles S.; de la Torre Noetzel, Rosa; Demets, René; de Vera, Jean-Pierre; d'Hendecourt, Louis; Ehrenfreund, Pascale; Elsaesser, Andreas; Foing, Bernard; Onofri, Silvano; Quinn, Richard; Rabbow, Elke; Rettberg, Petra; Ricco, Antonio J.; Slenzka, Klaus; Stalport, Fabien; ten Kate, Inge L.; van Loon, Jack J. W. A.; Westall, Frances

    2017-07-01

    Scientists use the Earth as a tool for astrobiology by analyzing planetary field analogues (i.e. terrestrial samples and field sites that resemble planetary bodies in our Solar System). In addition, they expose the selected planetary field analogues in simulation chambers to conditions that mimic the ones of planets, moons and Low Earth Orbit (LEO) space conditions, as well as the chemistry occurring in interstellar and cometary ices. This paper reviews the ways the Earth is used by astrobiologists: (i) by conducting planetary field analogue studies to investigate extant life from extreme environments, its metabolisms, adaptation strategies and modern biosignatures; (ii) by conducting planetary field analogue studies to investigate extinct life from the oldest rocks on our planet and its biosignatures; (iii) by exposing terrestrial samples to simulated space or planetary environments and producing a sample analogue to investigate changes in minerals, biosignatures and microorganisms. The European Space Agency (ESA) created a topical team in 2011 to investigate recent activities using the Earth as a tool for astrobiology and to formulate recommendations and scientific needs to improve ground-based astrobiological research. Space is an important tool for astrobiology (see Horneck et al. in Astrobiology, 16:201-243, 2016; Cottin et al., 2017), but access to space is limited. Complementing research on Earth provides fast access, more replications and higher sample throughput. The major conclusions of the topical team and suggestions for the future include more scientifically qualified calls for field campaigns with planetary analogy, and a centralized point of contact at ESA or the EU for the organization of a survey of such expeditions. An improvement of the coordinated logistics, infrastructures and funding system supporting the combination of field work with planetary simulation investigations, as well as an optimization of the scientific return and data processing

  11. Behavior and Performance on Long-Duration Spaceflights: Evidence from Analogue Environments

    Science.gov (United States)

    Palinkas, Lawrence A.; Gunderson, E. K. Eric; Johnson, Jeffrey C.; Holland, Albert W.

    1999-01-01

    Analyses of data collected in Antarctica since 1963 were conducted to identify features of behavior and performance likely to occur during long-duration missions in space.The influence of mission duration and station latitude on POMS mood scores was examined in 450 American men and women who overwintered in Antarctica between 1991 and 1998. The influence of crewmember social characteristics, personality traits, interpersonal needs, and station environments on measures of behavior and performance at the end of the austral winter was examined in 657 American men who overwintered between 1963 and 1974. Both data sets were used to examine the influence of crew social structure on individual performance. Results: Seasonal variations in mood appear to be associated with the altered diurnal cycle and psychological segmentation of the mission. Concurrent measures of personality, interpersonal needs, and coping styles are better predictors of depressed mood and peer-supervisor performance evaluations than baseline measures because of the unique features of the station social and physical environments and the absence of resources typically used to cope with stress elsewhere. Individuals in crews with a clique structure report significantly more depression, anxiety, anger, fatigue and confusion than individuals in crews with a core-periphery structure. Depressed mood is inversely associated with severity of station physical environment, supporting the existence of a positive or "salutogenic" effect for individuals seeking challenging experiences in extreme environments.

  12. Luciferase-Specific Coelenterazine Analogues for Optical Contamination-Free Bioassays

    OpenAIRE

    Ryo Nishihara; Masahiro Abe; Shigeru Nishiyama; Daniel Citterio; Koji Suzuki; Sung Bae Kim

    2017-01-01

    Spectral overlaps among the multiple optical readouts commonly cause optical contamination in fluorescence and bioluminescence. To tackle this issue, we created five-different lineages of coelenterazine (CTZ) analogues designed to selectively illuminate a specific luciferase with unique luciferase selectivity. In the attempt, we found that CTZ analogues with ethynyl or styryl groups display dramatically biased bioluminescence to specific luciferases and pHs by modifying the functional groups ...

  13. Synthesis and antioxidant activity of peptide-based ebselen analogues.

    Science.gov (United States)

    Satheeshkumar, Kandhan; Mugesh, Govindasamy

    2011-04-18

    A series of di- and tripeptide-based ebselen analogues has been synthesized. The compounds were characterized by (1)H, (13)C, and (77)Se NMR spectroscopy and mass spectral techniques. The glutathione peroxidase (GPx)-like antioxidant activity has been studied by using H(2)O(2) , tert-butyl hydroperoxide (tBuOOH), and cumene hydroperoxide (Cum-OOH) as substrates, and glutathione (GSH) as a cosubstrate. Although all the peptide-based compounds have a selenazole ring similar to that of ebselen, the GPx activity of these compounds highly depends on the nature of the peptide moiety attached to the nitrogen atom of the selenazole ring. It was observed that the introduction of a phenylalanine (Phe) amino acid residue in the N-terminal reduces the activity in all three peroxide systems. On the other hand, the introduction of aliphatic amino acid residues such as valine (Val) significantly enhances the GPx activity of the ebselen analogues. The difference in the catalytic activity of dipeptide-based ebselen derivatives can be ascribed mainly to the change in the reactivity of these compounds toward GSH and peroxide. Although the presence of the Val-Ala-CO(2) Me moiety facilitates the formation of a catalytically active selenol species, the reaction of ebselen analogues that has a Phe-Ile-CO(2) Me residue with GSH does not generate the corresponding selenol. To understand the antioxidant activity of the peptide-based ebselen analogues in the absence of GSH, these compounds were studied for their ability to inhibit peroxynitrite (PN)-mediated nitration of bovine serum albumin (BSA) and oxidation of dihydrorhodamine 123. In contrast to the GPx activity, the PN-scavenging activity of the Phe-based peptide analogues was found to be comparable to that of the Val-based compounds. However, the introduction of an additional Phe residue to the ebselen analogue that had a Val-Ala dipeptide significantly reduced the potency of the parent compound in PN-mediated nitration. Copyright

  14. Conjugate dynamical systems: classical analogue of the quantum energy translation

    International Nuclear Information System (INIS)

    Torres-Vega, Gabino

    2012-01-01

    An aspect of quantum mechanics that has not been fully understood is the energy shift generated by the time operator. In this study, we introduce the use of the eigensurfaces of dynamical variables and commutators in classical mechanics to study the classical analogue of the quantum translation of energy. We determine that there is a conjugate dynamical system that is conjugate to Hamilton's equations of motion, and then we generate the analogue of the time operator and use it in the translation of points along the energy direction, i.e. the classical analogue of the Pauli theorem. The theory is illustrated with a nonlinear oscillator model. (paper)

  15. Methyl mercury in terrestrial compartments

    International Nuclear Information System (INIS)

    Stoeppler, M.; Burow, M.; Padberg, S.; May, K.

    1993-09-01

    On the basis of the analytical methodology available at present the state of the art for the determination of total mercury and of various organometallic compounds of mercury in air, precipitation, limnic systems, soils, plants and biota is reviewed. This is followed by the presentation and discussion of examples for the data obtained hitherto for trace and ultratrace levels of total mercury and mainly methyl mercury in terrestrial and limnic environments as well as in biota. The data discussed stem predominantly from the past decade in which, due to significant methodological progress, many new aspects were elucidated. They include the most important results in this area achieved by the Research Centre (KFA) Juelich within the project 'Origin and Fate of Methyl Mercury' (contracts EV4V-0138-D and STEP-CT90-0057) supported by the Commission of the European Communities, Brussels. (orig.) [de

  16. Luciferase-Specific Coelenterazine Analogues for Optical Contamination-Free Bioassays.

    Science.gov (United States)

    Nishihara, Ryo; Abe, Masahiro; Nishiyama, Shigeru; Citterio, Daniel; Suzuki, Koji; Kim, Sung Bae

    2017-04-19

    Spectral overlaps among the multiple optical readouts commonly cause optical contamination in fluorescence and bioluminescence. To tackle this issue, we created five-different lineages of coelenterazine (CTZ) analogues designed to selectively illuminate a specific luciferase with unique luciferase selectivity. In the attempt, we found that CTZ analogues with ethynyl or styryl groups display dramatically biased bioluminescence to specific luciferases and pHs by modifying the functional groups at the C-2 and C-6 positions of the imidazopyradinone backbone of CTZ. The optical contamination-free feature was exemplified with the luciferase-specific CTZ analogues, which illuminated anti-estrogenic and rapamycin activities in a mixture of optical probes. This unique bioluminescence platform has great potential for specific and high throughput imaging of multiple optical readouts in bioassays without optical contamination.

  17. Assessment of potential risk of environmental radioactive contamination in northern Europe from terrestrial nuclear units in north-west Russia

    International Nuclear Information System (INIS)

    Lisovsky, I.; Baklanov, A.; Jacovlev, V.; Prutskov, V.; Bergman, R.

    1999-05-01

    This Technical Report, being part of the INTAS project 96-1802, constitutes a comprehensive presentation - covering basic results from separate contributions as specified below - of work performed during the first period (February 1998- February 1999). The aim of the INTAS project 96-1802: 'Assessment of potential risk of environmental radioactive contamination in northern Europe from terrestrial nuclear units in north-west Russia' is to assess the potential risk of environmental radioactive contamination from nuclear units in north-west Russia and resulting impacts on population and terrestrial ecosystems in the north. The work focuses mainly on airborne radioactive contamination, but some case studies also deal with accidental leakage from terrestrial nuclear sites to soil and coastal waters. The present material comprises in more detail the contributions from participants no.4 and no.5 based on the four internal reports referred to below: (1) Assessment of potential risk of environmental radioactive contamination in Northern Europe from terrestrial nuclear units in north-west Russia: 'Determination of the list of typical sources of danger emergency radioactive releases in an environment in connection with military activity in the North of Russia.' Technical report no.1 of the team no.5. St.-Petersburg State Technical University, St.-Petersburg. July 1998. 43 p.; (2) Assessment of potential risk of environmental radioactive contamination in Northern Europe from terrestrial nuclear units in North-west Russia: 'Analysis and description of source-term characteristics for accident linked with airborne radioactive releases from Kola Nuclear Power Plant. Establishing a network facility at INEP for communication among the INTAS Project participants.' Technical report no.1 of the team no.4. Kola Science Centre, Apatity. August 1998. 56 p.; (3) Assessment of potential risk of environmental radioactive contamination in Northern Europe from terrestrial nuclear units in

  18. Assessment of potential risk of environmental radioactive contamination in northern Europe from terrestrial nuclear units in north-west Russia

    Energy Technology Data Exchange (ETDEWEB)

    Lisovsky, I. [St. Petersburg State Technical Univ. (Russian Federation); Baklanov, A. [Inst. of the Northern Ecology Problems (INEP) (Russian Federation); Jacovlev, V. [St. Petersburg State Technical Univ. (Russian Federation); Prutskov, V. [Ministry of Defence (Russian Federation). First Central Research Inst. of Naval Shipbuilding; Tarasov, I. [Ministry of Defence (Russian Federation). 23 State Marine Project Inst.; Blecher, A. [State Unitary Enterprise (Russian Federation). Research Inst. of Industrial and Marine Medicine; Zvonariev, B.; Kuchin, N.; Rubanov, S.; Sergeiev, I. [State Scientific Centre (Russian Federation). Central Research Inst. of A. Krylov; Morozov, S.; Koshkin, V.; Fedorenko, Yu.; Rigina, O. [Inst. of the Northern Ecology Problems (INEP) (Russian Federation); Bergman, R. [ed.] [Defence Research Establishment, Umeaa (Sweden). Div. of NBC Defence

    1999-05-01

    This Technical Report, being part of the INTAS project 96-1802, constitutes a comprehensive presentation - covering basic results from separate contributions as specified below - of work performed during the first period (February 1998- February 1999). The aim of the INTAS project 96-1802: `Assessment of potential risk of environmental radioactive contamination in northern Europe from terrestrial nuclear units in north-west Russia` is to assess the potential risk of environmental radioactive contamination from nuclear units in north-west Russia and resulting impacts on population and terrestrial ecosystems in the north. The work focuses mainly on airborne radioactive contamination, but some case studies also deal with accidental leakage from terrestrial nuclear sites to soil and coastal waters. The present material comprises in more detail the contributions from participants no.4 and no.5 based on the four internal reports referred to below: (1) Assessment of potential risk of environmental radioactive contamination in Northern Europe from terrestrial nuclear units in north-west Russia: `Determination of the list of typical sources of danger emergency radioactive releases in an environment in connection with military activity in the North of Russia.` Technical report no.1 of the team no.5. St.-Petersburg State Technical University, St.-Petersburg. July 1998. 43 p.; (2) Assessment of potential risk of environmental radioactive contamination in Northern Europe from terrestrial nuclear units in North-west Russia: `Analysis and description of source-term characteristics for accident linked with airborne radioactive releases from Kola Nuclear Power Plant. Establishing a network facility at INEP for communication among the INTAS Project participants.` Technical report no.1 of the team no.4. Kola Science Centre, Apatity. August 1998. 56 p.; (3) Assessment of potential risk of environmental radioactive contamination in Northern Europe from terrestrial nuclear units in

  19. Sensitivity of groundwater recharge using climatic analogues and HYDRUS-1D

    Directory of Open Access Journals (Sweden)

    B. Leterme

    2012-08-01

    Full Text Available The sensitivity of groundwater recharge to different climate conditions was simulated using the approach of climatic analogue stations, i.e. stations presently experiencing climatic conditions corresponding to a possible future climate state. The study was conducted in the context of a safety assessment of a future near-surface disposal facility for low and intermediate level short-lived radioactive waste in Belgium; this includes estimation of groundwater recharge for the next millennia. Groundwater recharge was simulated using the Richards based soil water balance model HYDRUS-1D and meteorological time series from analogue stations. This study used four analogue stations for a warmer subtropical climate with changes of average annual precipitation and potential evapotranspiration from −42% to +5% and from +8% to +82%, respectively, compared to the present-day climate. Resulting water balance calculations yielded a change in groundwater recharge ranging from a decrease of 72% to an increase of 3% for the four different analogue stations. The Gijon analogue station (Northern Spain, considered as the most representative for the near future climate state in the study area, shows an increase of 3% of groundwater recharge for a 5% increase of annual precipitation. Calculations for a colder (tundra climate showed a change in groundwater recharge ranging from a decrease of 97% to an increase of 32% for four different analogue stations, with an annual precipitation change from −69% to −14% compared to the present-day climate.

  20. Optoelectronic properties of higher acenes, their BN analogue and substituted derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Armaković, Stevan, E-mail: stevan.armakovic@df.uns.ac.rs [University of Novi Sad, Faculty of Sciences, Department of Physics, Trg Dositeja Obradovića 4, 21000, Novi Sad (Serbia); Armaković, Sanja J. [University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, 21000, Novi Sad (Serbia); Holodkov, Vladimir [Educons University, Faculty of Sport and Tourism - TIMS, Radnička 30a, 21000, Novi Sad (Serbia); Pelemiš, Svetlana [University of East Sarajevo, Faculty of Technology, Karakaj bb, 75400, Zvornik, Republic of Srpska, Bosnia and Herzegovina (Bosnia and Herzegovina)

    2016-02-15

    We have investigated optoelectronic properties of higher acenes: pentacene, hexacene, heptacene, octacene, nonacene, decacene and their boron-nitride (BN) analogues, within the framework of density functional theory (DFT). We have also investigated the optoelectronic properties of acenes modified by BN substitution. Calculated optoelectronic properties encompasses: oxidation and reduction potentials, electron and hole reorganization energies and energy difference between excited first singlet and triplet states ΔE(S{sub 1}−T{sub 1}). Oxidation and reduction potentials indicate significantly better stability of BN analogues, comparing with their all-carbon relatives. Although higher acenes possess lower electron and hole reorganization energies, with both best values much lower than 0.1 eV, their BN analogues also have competitive values of reorganization energies, especially for holes for which reorganization energy is also lower than 0.1 eV. On the other hand ΔE(S{sub 1}−T{sub 1}) is much better for BN analogues, having values that indicate that BN analogues are possible applicable for thermally activated delayed fluorescence. - Highlights: • Optoelectronic properties of structures based on higher acenes have been investigated. • Oxidation and reduction potentials together with reorganization energies are calculated. • TADF is analyzed through calculation of ΔE(S{sub 1}−T{sub 1}), which is much better for BN analogues. • Reorganization energies of acenes improve with the increase of number of benzene rings.

  1. Liposomes containing alkylated methotrexate analogues for phospholipase A(2) mediated tumor targeted drug delivery

    DEFF Research Database (Denmark)

    Kaasgaard, Thomas; Andresen, Thomas Lars; Jensen, Simon Skøde

    2009-01-01

    of alkylated compounds in liposomes, it was demonstrated that the MTX-analogue partitioned into the water phase and thereby became available for cell uptake. It was concluded that liposomes containing alkylated MTX-analogues show promise as a drug delivery system, although the MTX-analogue needs to be more......Two lipophilic methotrexate analogues have been synthesized and evaluated for cytotoxicity against KATO III and HT-29 human colon cancer cells. Both analogues contained a C-16-alkyl chain attached to the gamma-carboxylic acid and one of the analogues had an additional benzyl group attached...... cytotoxicity was incorporated into liposomes that were designed to be particularly Susceptible to a liposome degrading enzyme, secretory phospholipase A(2) (sPLA(2)), which is found in high concentrations in tumors of several different cancer types. Liposome incorporation was investigated by differential...

  2. Insulin analogues: have they changed insulin treatment and improved glycaemic control?

    DEFF Research Database (Denmark)

    Madsbad, Sten

    2002-01-01

    To improve insulin therapy, new insulin analogues have been developed. Two fast-acting analogues with a more rapid onset of effect and a shorter duration of action combined with a low day-to-day variation in absorption rate are now available. Despite this favourable time-action profile most studies....... This is probably the main explanation for the absence of improvement in overall glycaemic control when compared with regular human insulin. A tendency to a reduction in hypoglycaemic events during treatment with fast-acting analogues has been observed in most studies. Recent studies have indicated that NPH insulin...... administered several times daily at mealtimes can improve glycaemic control without increasing the risk of hypoglycaemia. The fast-acting analogues are now also available as insulin mixed with NPH. Insulin glargine is a new long-acting insulin which is soluble and precipitates after injection, resulting...

  3. ANALYSIS OF TERRESTRIAL LASER SCANNING AND PHOTOGRAMMETRY DATA FOR DOCUMENTATION OF HISTORICAL ARTIFACTS

    Directory of Open Access Journals (Sweden)

    R. A. Kuçak

    2016-10-01

    Full Text Available Historical artifacts living from the past until today exposed to many destructions non-naturally or naturally. For this reason, The protection and documentation studies of Cultural Heritage to inform the next generations are accelerating day by day in the whole world. The preservation of historical artifacts using advanced 3D measurement technologies becomes an efficient tool for mapping solutions. There are many methods for documentation and restoration of historic structures. In addition to traditional methods such as simple hand measurement and tachometry, terrestrial laser scanning is rapidly becoming one of the most commonly used techniques due to its completeness, accuracy and fastness characteristics. This study evaluates terrestrial laser scanning(TLS technology and photogrammetry for documenting the historical artifacts facade data in 3D Environment. PhotoModeler software developed by Eos System was preferred for Photogrammetric method. Leica HDS 6000 laser scanner developed by Leica Geosystems and Cyclone software which is the laser data evaluation software belonging to the company is preferred for Terrestrial Laser Scanning method. Taking into account the results obtained with this software product is intended to provide a contribution to the studies for the documentation of cultural heritage.

  4. Sources and characteristics of terrestrial carbon in Holocene-scale sediments of the East Siberian Sea

    Science.gov (United States)

    Keskitalo, Kirsi; Tesi, Tommaso; Bröder, Lisa; Andersson, August; Pearce, Christof; Sköld, Martin; Semiletov, Igor P.; Dudarev, Oleg V.; Gustafsson, Örjan

    2017-09-01

    Thawing of permafrost carbon (PF-C) due to climate warming can remobilise considerable amounts of terrestrial carbon from its long-term storage to the marine environment. PF-C can be then be buried in sediments or remineralised to CO2 with implications for the carbon-climate feedback. Studying historical sediment records during past natural climate changes can help us to understand the response of permafrost to current climate warming. In this study, two sediment cores collected from the East Siberian Sea were used to study terrestrial organic carbon sources, composition and degradation during the past ˜ 9500 cal yrs BP. CuO-derived lignin and cutin products (i.e., compounds solely biosynthesised in terrestrial plants) combined with δ13C suggest that there was a higher input of terrestrial organic carbon to the East Siberian Sea between ˜ 9500 and 8200 cal yrs BP than in all later periods. This high input was likely caused by marine transgression and permafrost destabilisation in the early Holocene climatic optimum. Based on source apportionment modelling using dual-carbon isotope (Δ14C, δ13C) data, coastal erosion releasing old Pleistocene permafrost carbon was identified as a significant source of organic matter translocated to the East Siberian Sea during the Holocene.

  5. Mixing of Marine and Terrestrial Sources of Strontium in Coastal Environments

    Science.gov (United States)

    Ryan, Saskia; Crowley, Quentin; Deegan, Eileen; Snoeck, Christophe

    2017-04-01

    87Sr/86Sr from bulk soils, soil extracts and plant material have been used to investigate and quantify the extent of marine-derived Sr in the terrestrial biosphere. Samples were collected along coastal transects and 87Sr/86Sr biosphere values (plant and soil) converge to marine values with increasing proximity to the coast. R2values indicate highly significant trends in certain regions. The National Soils Database (NSDB), TELLUS and TELLUS Border datasets, all of which are geochemical surveys have been employed to further test the extent of marine elemental contribution. Collectively these data cover all of Ireland and Northern Ireland, with varying degrees of sampling density. A strong spatial correlation exists between the Chemical Index of Alteration (CIA; (Al2O3-(CaO*+Na2O)-K2O)) in topsoil (CIA <60; 27% n = 11651) and areas of blanket peat. The enrichment of Ca and Na in these regions would suggest a significant marine geochemical contribution. Topsoil CIA can therefore be used to identify areas likely to feature significant marine inputs and identify regions where the 87Sr/86Sr budget may deviate from bedrock values.

  6. Insights into the nature of cometary organic matter from terrestrial analogues

    Science.gov (United States)

    Court, Richard W.; Sephton, Mark A.

    2012-04-01

    The nature of cometary organic matter is of great interest to investigations involving the formation and distribution of organic matter relevant to the origin of life. We have used pyrolysis-Fourier transform infrared (FTIR) spectroscopy to investigate the chemical effects of the irradiation of naturally occurring bitumens, and to relate their products of pyrolysis to their parent assemblages. The information acquired has then been applied to the complex organic matter present in cometary nuclei and comae. Amalgamating the FTIR data presented here with data from published studies enables the inference of other comprehensive trends within hydrocarbon mixtures as they are progressively irradiated in a cometary environment, namely the polymerization of lower molecular weight compounds; an increased abundance of polycyclic aromatic hydrocarbon structures; enrichment in 13C; reduction in atomic H/C ratio; elevation of atomic O/C ratio and increase in the temperature required for thermal degradation. The dark carbonaceous surface of a cometary nucleus will display extreme levels of these features, relative to the nucleus interior, while material in the coma will reflect the degree of irradiation experienced by its source location in the nucleus. Cometary comae with high methane/water ratios indicate a nucleus enriched in methane, favouring the formation of complex organic matter via radiation-induced polymerization of simple precursors. In contrast, production of complex organic matter is hindered in a nucleus possessing a low methane/water ration, with the complex organic matter that does form possessing more oxygen-containing species, such as alcohol, carbonyl and carboxylic acid functional groups, resulting from reactions with hydroxyl radicals formed by the radiolysis of the more abundant water. These insights into the properties of complex cometary organic matter should be of particular interest to both remote observation and space missions involving in situ

  7. Synthesis of the 4’-desmethoxy analogue of RU79115

    Directory of Open Access Journals (Sweden)

    MICHEL KLICH

    2004-11-01

    Full Text Available The synthesis, and biological activity in vitro of the 4’-desmethoxy analogue (3 of RU 79115 (2 is described. Comparison of the biological activity of the two analogues clearly indicated the importance of the 4’-methoxy group in conferring good gyrase B inhibitory activity as well as antibacterial activity.

  8. Nucleoside analogues are activated by bacterial deoxyribonucleoside kinases in a species-specific manner

    DEFF Research Database (Denmark)

    Sandrini, Michael; Clausen, Anders; On, Stephen L. W.

    2007-01-01

    To investigate the bactericidal activity of antiviral and anticancer nucleoside analogues against a variety of pathogenic bacteria and characterize the activating enzymes, deoxyribonucleoside kinases (dNKs). Several FDA-approved nucleoside analogue drugs were screened for their potential bacteric......-specific manner. Therefore, nucleoside analogues have a potential to be employed as antibiotics in the fight against emerging multiresistant bacteria....

  9. Terrestrial ecology

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    The main effort of the Terrestrial Ecology Division has been redirected to a comprehensive study of the Espiritu Santo Drainage Basin located in northeastern Puerto Rico. The general objective are to provide baseline ecological data for future environmental assessment studies at the local and regional levels, and to provide through an ecosystem approach data for the development of management alternatives for the wise utilization of energy, water, and land resources. The interrelationships among climate, vegetation, soils, and man, and their combined influence upon the hydrologic cycle will be described and evaluated. Environmental management involves planning and decision making, and both require an adequate data base. At present, little is known about the interworkings of a complete, integrated system such as a drainage basin. A literature survey of the main research areas confirmed that, although many individual ecologically oriented studies have been carried out in a tropical environment, few if any provide the data base required for environmental management. In view of rapidly changing socio-economic conditions and natural resources limitations, management urgently requires data from these systems: physical (climatological), biological, and cultural. This integrated drainage basin study has been designed to provide such data. The scope of this program covers the hydrologic cycle as it is affected by the interactions of the physical, biological, and cultural systems

  10. Space environment studies for the SZ-4 spacecraft

    International Nuclear Information System (INIS)

    Ye Zonghai

    2004-01-01

    The space environment, especially the solar-terrestrial space environment, has close bearings on mankind's astronautical activities. An overview is presented of the space environment and safeguard services on the 'SZ' series of spacecraft, with special reference to the SZ-4 spacecraft. These include monitoring of the space environment on SZ-4, studies on its distribution, variation and effects on astronautical performance, as well as space environment forecasts for safe launching, normal operation and safe return of SZ-4. Current progress both in China and overseas is covered

  11. Reasoning by analogy: rational foundation of natural analogue studies

    International Nuclear Information System (INIS)

    Petit, J.-C.

    1992-01-01

    Long-term extrapolations concerning the safety of a nuclear waste repository cannot be satisfactorily made on the sole basis of short-term laboratory investigations. Most nuclear countries have hence developed an approach relying on the following research directions: 1. laboratory experiments; 2. in situ testing; 3. modeling; and 4. natural analogues, which are the only means by which very slow mechanisms can be identified and by which long-term predictions of models can be tested for pertinence (if not truly validated). Although the field of natural analogues has grown very rapidly in recent years, receiving support from varied specialists and institutions involved in radioactive waste disposal, there is not yet a full consensus on their actual usefulness. More problematic is the criticism sometimes made that analogical reasoning is not ''true science'' and that information retrieved from the study of natural analogues will always remain questionable. The present paper gives some clues about the exact status of reasoning by analogy, compared to more ''scientific'' ways of deriving information from investigated systems. It is not a thorough discussion of this very complex, and by far too philosophical issue but we hope, at least, to present to readers of papers devoted to natural analogue studies arguments showing that this approach has some sound foundation. (author)

  12. Woody plant encroachment of grasslands: a comparison of terrestrial and wetland settings.

    Science.gov (United States)

    Saintilan, Neil; Rogers, Kerrylee

    2015-02-01

    A global trend of woody plant encroachment of terrestrial grasslands is co-incident with woody plant encroachment of wetland in freshwater and saline intertidal settings. There are several arguments for considering tree encroachment of wetlands in the context of woody shrub encroachment of grassland biomes. In both cases, delimitation of woody shrubs at regional scales is set by temperature thresholds for poleward extent, and by aridity within temperature limits. Latitudinal expansion has been observed for terrestrial woody shrubs and mangroves, following recent warming, but most expansion and thickening has been due to the occupation of previously water-limited grassland/saltmarsh environments. Increases in atmospheric CO₂, may facilitate the recruitment of trees in terrestrial and wetland settings. Improved water relations, a mechanism that would predict higher soil moisture in grasslands and saltmarshes, and also an enhanced capacity to survive arid conditions, reinforces local mechanisms of change. The expansion of woody shrubs and mangroves provides a negative feedback on elevated atmospheric CO₂ by increasing carbon sequestration in grassland and saltmarsh, and is a significant carbon sink globally. These broad-scale vegetation shifts may represent a new stable state, reinforced by positive feedbacks between global change drivers and endogenic mechanisms of persistence in the landscape.

  13. A Low-cost Multi-channel Analogue Signal Generator

    CERN Document Server

    Muller, F; Shen, W; Stamen, R

    2009-01-01

    A scalable multi-channel analogue signal generator is presented. It uses a commercial low-cost graphics card with multiple outputs in a standard PC as signal source. Each color signal serves as independent channel to generate an analogue signal. A custom-built external PCB was developed to adjust the graphics card output voltage levels for a specific task, which needed differential signals. The system furthermore comprises a software package to program the signal shape. The implementation of the signal generator is presented as well as an application where it was successfully utilized.

  14. A regulator's perspective on the use of analogues for regulatory confidence

    International Nuclear Information System (INIS)

    Ruiz, Carmen

    2008-01-01

    The NAA Study, promoted and coordinated by the CSN, was carried out in collaboration with ENRESA by CIEMAT and three Spanish Universities UZ, UDC and UCM. The 3 year Study, included in the CSN's R and D Programme, started in 1999, is focussed on Deep Geological disposal (DGD). CSN motivation for NA Analogues arose in 1997 as result of the emerging approaches to increase the confidence in the Safety Assessment (SA) considering multiple lines of reasoning show in: some international documents and some national regulation. After a first preliminary (1997-1998) study, the CSN noticed the large amount and dispersion of the information about NNA, and decided to launch a deeper Study with the aims of: Collecting and reviewing the results of all the relevant studies on analogues developed in the last decades in systematic way; Reaching a better understanding of their potential and real application to the SA and for communication purposes. The results of the Analogue Study has been structured in several documents with different levels of detail and technical content addressed to different audiences. Analogue studies are a source of knowledge for the understanding of the long-term behavior of DGD systems. They represent a complementary method to increase Confidence Building within PA. In the majority of the cases, analogues have been used to transmit information on generic aspects of the geological concept an easily understood message. The need to simplify the content to facilitate their understanding may imply different information to different audiences. Analogue studies are: Considered within the multiple lines of reasoning to increase the confidence in the SA; A source of knowledge for the understanding of the long-term behavior of DGD systems. They represent a complementary method to increase Confidence Building within SA. There are few examples of the direct use of data from natural analogue projects in the consulted SA. They are promoted by International organisations

  15. Excretory nitrogen metabolism in the juvenile axolotl Ambystoma mexicanum: differences in aquatic and terrestrial environments.

    Science.gov (United States)

    Loong, Ai M; Chew, Shit F; Ip, Yuen K

    2002-01-01

    The fully grown but nonmetamorphosed (juvenile) axolotl Ambystoma mexicanum was ureogenic and primarily ureotelic in water. A complete ornithine-urea cycle (OUC) was present in the liver. Aerial exposure impeded urea (but not ammonia) excretion, leading to a decrease in the percentage of nitrogen excreted as urea in the first 24 h. However, urea and not ammonia accumulated in the muscle, liver, and plasma during aerial exposure. By 48 h, the rate of urea excretion recovered fully, probably due to the greater urea concentration gradient in the kidney. It is generally accepted that an increase in carbamoyl phosphate synthetase activity is especially critical in the developmental transition from ammonotelism to ureotelism in the amphibian. Results from this study indicate that such a transition in A. mexicanum would have occurred before migration to land. Aerial exposure for 72 h exhibited no significant effect on carbamoyl phosphate synthetase-I activity or that of other OUC enzymes (with the exception of ornithine transcarbamoylase) from the liver of the juvenile A. mexicanum. This supports our hypothesis that the capacities of OUC enzymes present in the liver of the aquatic juvenile axolotl were adequate to prepare it for its invasion of the terrestrial environment. The high OUC capacity was further supported by the capability of the juvenile A. mexicanum to survive in 10 mM NH(4)Cl without accumulating amino acids in its body. The majority of the accumulating endogenous and exogenous ammonia was detoxified to urea, which led to a greater than twofold increase in urea levels in the muscle, liver, and plasma and a significant increase in urea excretion by hour 96. Hence, it can be concluded that the juvenile axolotl acquired ureotelism while submerged in water, and its hepatic capacity of urea synthesis was more than adequate to handle the toxicity of endogenous ammonia during migration to land.

  16. THE PENA BLANCA NATURAL ANALOGUE PERFORMANCE ASSESSMENT MODEL

    Energy Technology Data Exchange (ETDEWEB)

    G.J. Saulnier Jr; W. Statham

    2006-03-10

    The Nopal I uranium mine in the Sierra Pena Blanca, Chihuahua, Mexico serves as a natural analogue to the Yucca Mountain repository. The Pena Blanca Natural Analogue Performance Assessment Model simulates the mobilization and transport of radionuclides that are released from the mine and transported to the saturated zone. the Pena Blanca Natural Analogue Model uses probabilistic simulations of hydrogeologic processes that are analogous to the processes that occur at the Yucca Mountain site. The Nopal I uranium deposit lies in fractured, welded, and altered rhyolitic ash flow tuffs that overlie carbonate rocks, a setting analogous to the geologic formations at the Yucca Mountain site. The Nopal I mine site has the following characteristics as compared to the Yucca Mountain repository site. (1) Analogous source: UO{sub 2} uranium ore deposit = spent nuclear fuel in the repository; (2) Analogous geologic setting: fractured, welded, and altered rhyolitic ash flow tuffs overlying carbonate rocks; (3) Analogous climate: Semiarid to arid; (4) Analogous geochemistry: Oxidizing conditions; and (5) Analogous hydrogeology: The ore deposit lies in the unsaturated zone above the water table. The Nopal I deposit is approximately 8 {+-} 0.5 million years old and has been exposed to oxidizing conditions during the last 3.2 to 3.4 million years. The Pena Blanca Natural Analogue Model considers that the uranium oxide and uranium silicates in the ore deposit were originally analogous to uranium-oxide spent nuclear fuel. The Pena Blanca site has been characterized using field and laboratory investigations of its fault and fracture distribution, mineralogy, fracture fillings, seepage into the mine adits, regional hydrology, and mineralization that shows the extent of radionuclide migration. Three boreholes were drilled at the Nopal I mine site in 2003 and these boreholes have provided samples for lithologic characterization, water-level measurements, and water samples for laboratory

  17. THE PENA BLANCA NATURAL ANALOGUE PERFORMANCE ASSESSMENT MODEL

    International Nuclear Information System (INIS)

    G.J. Saulnier Jr; W. Statham

    2006-01-01

    The Nopal I uranium mine in the Sierra Pena Blanca, Chihuahua, Mexico serves as a natural analogue to the Yucca Mountain repository. The Pena Blanca Natural Analogue Performance Assessment Model simulates the mobilization and transport of radionuclides that are released from the mine and transported to the saturated zone. the Pena Blanca Natural Analogue Model uses probabilistic simulations of hydrogeologic processes that are analogous to the processes that occur at the Yucca Mountain site. The Nopal I uranium deposit lies in fractured, welded, and altered rhyolitic ash flow tuffs that overlie carbonate rocks, a setting analogous to the geologic formations at the Yucca Mountain site. The Nopal I mine site has the following characteristics as compared to the Yucca Mountain repository site. (1) Analogous source: UO 2 uranium ore deposit = spent nuclear fuel in the repository; (2) Analogous geologic setting: fractured, welded, and altered rhyolitic ash flow tuffs overlying carbonate rocks; (3) Analogous climate: Semiarid to arid; (4) Analogous geochemistry: Oxidizing conditions; and (5) Analogous hydrogeology: The ore deposit lies in the unsaturated zone above the water table. The Nopal I deposit is approximately 8 ± 0.5 million years old and has been exposed to oxidizing conditions during the last 3.2 to 3.4 million years. The Pena Blanca Natural Analogue Model considers that the uranium oxide and uranium silicates in the ore deposit were originally analogous to uranium-oxide spent nuclear fuel. The Pena Blanca site has been characterized using field and laboratory investigations of its fault and fracture distribution, mineralogy, fracture fillings, seepage into the mine adits, regional hydrology, and mineralization that shows the extent of radionuclide migration. Three boreholes were drilled at the Nopal I mine site in 2003 and these boreholes have provided samples for lithologic characterization, water-level measurements, and water samples for laboratory analysis

  18. NASA Astronaut Occupational Surveillance Program and Lifetime Surveillance of Astronaut Health, LSAH, Astronaut Exposures and Risk in the Terrestrial and Spaceflight Environment

    Science.gov (United States)

    Keprta, Sean R.; Tarver, William; Van Baalen, Mary; McCoy, Torin

    2015-01-01

    United States Astronauts have a very unique occupational exposure profile. In order to understand these risks and properly address them, the National Aeronautics and Atmospheric Administration, NASA, originally created the Longitudinal Study of Astronaut Health, LSAH. The first LSAH was designed to address a variety of needs regarding astronaut health and included a 3 to 1 terrestrial control population in order to compare United States "earth normal" disease and aging to that of a microgravity exposed astronaut. Over the years that program has been modified, now termed Lifetime Surveillance of Astronaut Health, still LSAH. Astronaut spaceflight exposures have also changed, with the move from short duration shuttle flights to long duration stays on international space station and considerable terrestrial training activities. This new LSAH incorporates more of an occupational health and medicine model to the study of occupationally exposed astronauts. The presentation outlines the baseline exposures and monitoring of the astronaut population to exposures, both terrestrial, and in space.

  19. The IAEA/CEC programme on validation of models for radionuclide transfer in terrestrial, aquatic and urban environments (VAMP)

    International Nuclear Information System (INIS)

    Linsley, G.S.; Templeton, W.L.; Sinnaeve, J.

    1991-01-01

    In the application of radiological assessment models there is a continuous need to provide evidence of the reliability of model predictions. Ideally models should be developed and tested using data on the transfer of the nuclides of interest in the actual environment being modelled. Very often such measurements are not available and, in some cases, they are impossible to obtain. Reliance has usually to be placed on results taken from similar but different environmental conditions or from laboratory studies. Considerable use has been made of the environmental contamination that resulted from the fallout from the nuclear weapons testing in the 1950s and 1960s for model development and testing. The very special opportunities that exist at the present time in the European parts of the USSR and in Europe generally for the acquisition of data sets appropriate for model testing and for the calibration of radiological assessment models have justified the establishment of an international programme aimed at collating the data from different countries and at co-ordinating work on model testing studies. The VAMP study began in 1988 and currently involves scientists from 23 countries. (VAMP is an acronym for Validation of Model Predictions). This report describes the aims, methods of work and progress of the four VAMP working groups (Terrestrial, Aquatic, Urban and Multiple Pathways)

  20. Terrestrial carbohydrates support freshwater zooplankton during phytoplankton deficiency.

    Science.gov (United States)

    Taipale, Sami J; Galloway, Aaron W E; Aalto, Sanni L; Kahilainen, Kimmo K; Strandberg, Ursula; Kankaala, Paula

    2016-08-11

    Freshwater food webs can be partly supported by terrestrial primary production, often deriving from plant litter of surrounding catchment vegetation. Although consisting mainly of poorly bioavailable lignin, with low protein and lipid content, the carbohydrates from fallen tree leaves and shoreline vegetation may be utilized by aquatic consumers. Here we show that during phytoplankton deficiency, zooplankton (Daphnia magna) can benefit from terrestrial particulate organic matter by using terrestrial-origin carbohydrates for energy and sparing essential fatty acids and amino acids for somatic growth and reproduction. Assimilated terrestrial-origin fatty acids from shoreline reed particles exceeded available diet, indicating that Daphnia may convert a part of their dietary carbohydrates to saturated fatty acids. This conversion was not observed with birch leaf diets, which had lower carbohydrate content. Subsequent analysis of 21 boreal and subarctic lakes showed that diet of herbivorous zooplankton is mainly based on high-quality phytoplankton rich in essential polyunsaturated fatty acids. The proportion of low-quality diets (bacteria and terrestrial particulate organic matter) was <28% of the assimilated carbon. Taken collectively, the incorporation of terrestrial carbon into zooplankton was not directly related to the concentration of terrestrial organic matter in experiments or lakes, but rather to the low availability of phytoplankton.

  1. Comparative Metagenomics of Eight Geographically Remote Terrestrial Hot Springs.

    Science.gov (United States)

    Menzel, Peter; Gudbergsdóttir, Sóley Ruth; Rike, Anne Gunn; Lin, Lianbing; Zhang, Qi; Contursi, Patrizia; Moracci, Marco; Kristjansson, Jakob K; Bolduc, Benjamin; Gavrilov, Sergey; Ravin, Nikolai; Mardanov, Andrey; Bonch-Osmolovskaya, Elizaveta; Young, Mark; Krogh, Anders; Peng, Xu

    2015-08-01

    Hot springs are natural habitats for thermophilic Archaea and Bacteria. In this paper, we present the metagenomic analysis of eight globally distributed terrestrial hot springs from China, Iceland, Italy, Russia, and the USA with a temperature range between 61 and 92 (∘)C and pH between 1.8 and 7. A comparison of the biodiversity and community composition generally showed a decrease in biodiversity with increasing temperature and decreasing pH. Another important factor shaping microbial diversity of the studied sites was the abundance of organic substrates. Several species of the Crenarchaeal order Thermoprotei were detected, whereas no single bacterial species was found in all samples, suggesting a better adaptation of certain archaeal species to different thermophilic environments. Two hot springs show high abundance of Acidithiobacillus, supporting the idea of a true thermophilic Acidithiobacillus species that can thrive in hyperthermophilic environments. Depending on the sample, up to 58 % of sequencing reads could not be assigned to a known phylum, reinforcing the fact that a large number of microorganisms in nature, including those thriving in hot environments remain to be isolated and characterized.

  2. Louisiana ESI: T_MAMMAL (Terrestrial Mammal Polygons)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains sensitive biological resource data for terrestrial mammals in Louisiana. Vector polygons in this data set represent terrestrial mammal...

  3. Accumulation of radium in relation to some chemical analogues in Dicranopteris linearis

    International Nuclear Information System (INIS)

    Chao, J.H.; Chuang, C.Y.

    2011-01-01

    This study elucidates the uptake and accumulation of radium in the field-growing fern Dicranopteris linearis by relating the radium concentration to some potential chemical analogues, including alkaline earth metals, rare earth elements, and some important heavy metals. Time-dependent accumulation of radium and these chemical analogues for D. linearis were described by the 228 Th/ 228 Ra activity ratio, an index for inferring plant age. The correlation between radium and these elements was assessed by statistical analysis and used as a reference to elucidate the uptake and accumulation of radium in relation to the chemical analogues. Analytical and statistical results showed that the concentrations of alkaline earth metals (except for Mg) rare earth elements and some heavy metals in D. linearis increased linearly with plant age. These elements, exhibiting a similar accumulation pattern to radium and significant correlation coefficients with radium, were considered as the chemical analogues to radium. Additionally, the plant/soil concentration ratios (CRs) for radium and most of these analogues in D. linearis exceeded 1, consistent with the definition of hyper-accumulator plants.

  4. Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid

    Directory of Open Access Journals (Sweden)

    Patrick Rabe

    2014-08-01

    Full Text Available Tropodithietic acid (TDA is a structurally unique sulfur-containing antibiotic from the Roseobacter clade bacterium Phaeobacter inhibens DSM 17395 and a few other related species. We have synthesised several structural analogues of TDA and used them in bioactivity tests against Staphylococcus aureus and Vibrio anguillarum for a structure–activity relationship (SAR study, revealing that the sulfur-free analogue of TDA, tropone-2-carboxylic acid, has an antibiotic activity that is even stronger than the bioactivity of the natural product. The synthesis of this compound and of several analogues is presented and the bioactivity of the synthetic compounds is discussed.

  5. Somatostatin analogues labelled with 99mTc

    International Nuclear Information System (INIS)

    Obenaus, Esteban R.; Crudo, Jose L.; Edreira, Martin M.; Castiglia, Silvia G.

    1999-01-01

    Biological and radiochemical studies have been carried out on two labelled somatostatin analogues, the peptide RC-150 and the Tyr 3 -Octreotide. Both analogues have been labelled with 99m Tc using the direct and the indirect method and MAG-3 and HYNIC as chelating agents. By the direct method RC-150 was labelled using sodium ascorbate and dithionite as reducing agents. The radiochemical purity was 70%. By the indirect method, in the case of RC-160 with MAG-3 a radiochemical purity higher than 70% was attained while a purity of 100% was reached in the case of Tyr 3 -Octreotide with HYNIC. The biological distribution of HYNIC-Tyr 3 -Octreotide has been studied in rats. (author)

  6. Boron hydride analogues of the fullerenes

    International Nuclear Information System (INIS)

    Quong, A.A.; Pederson, M.R.; Broughton, J.Q.

    1994-01-01

    The BH moiety is isoelectronic with C. We have studied the stability of the (BH) 60 analogue of the C 60 fullerene as well as the dual-structure (BH) 32 icosahedron, both of them being putative structures, by performing local-density-functional electronic calculations. To aid in our analysis, we have also studied other homologues of these systems. We find that the latter, i.e., the dual structure, is the more stable although the former is as stable as one of the latter's lower homologues. Boron hydrides, it seems, naturally form the dual structures used in algorithmic optimization of complex fullerene systems. Fully relaxed geometries are reported as well as electron affinities and effective Hubbard U parameters. These systems form very stable anions and we conclude that a search for BH analogues of the C 60 alkali-metal supeconductors might prove very fruitful

  7. Thymidine analogue-sparing highly active antiretroviral therapy (HAART).

    Science.gov (United States)

    Nolan, David; Mallal, Simon

    2003-02-01

    The use of alternative nucleoside reverse transcriptase inhibitors (NRTIs) to the thymidine analogues stavudine (d4T) and zidovudine(ZDV) has been advocated as a means of limiting long-term NRTI-associated toxicity, particularly the development of lipoatrophy or fat wasting. This approach reflects an increasing knowledge of the distinct toxicity profiles of NRTI drugs. However, recent clinical trials have demonstrated that the use of thymidine analogue NRTIs and newer alternative backbone NRTIs, such as tenofovir (TNF) and abacavir (ABC), is associated with comparable short-term efficacy and tolerability. Given the importance of toxicity profile differences in determining clinical management, it is important to recognise that d4T and ZDV cary significantly different risks for long-term NRTI toxicity. Recognising that all NRTIs, including thymidine analogues, have individual toxicity profiles provides a more appropriate basis for selecting optimal antiretroviral therapy. The safety and efficacy of TNF and ABC are also reviewed here, although the available data provide only limited knowledge of the long-term effects of these drugs in terms of toxicity and antiviral durability.

  8. In vitro and in vivo potency of insulin analogues designed for clinical use.

    Science.gov (United States)

    Vølund, A; Brange, J; Drejer, K; Jensen, I; Markussen, J; Ribel, U; Sørensen, A R; Schlichtkrull, J

    1991-11-01

    Analogues of human insulin designed to have improved absorption properties after subcutaneous injection have been prepared by recombinant DNA technology. Five rapidly absorbed analogues, being predominantly in mono- or di-meric states in the pharmaceutical preparation, and a hexameric analogue with very low solubility at neutral pH and slow absorption, were studied. Receptor binding assays with HEP-G2 cells showed overall agreement with mouse free adipocyte assays. Two analogues, B28Asp and A21Gly + B27Arg + B30Thr-NH2, had nearly the same molar in vitro potency as human insulin. Another two showed increased adipocyte potency and receptor binding, B10Asp 194% and 333% and A8His + B4His + B10Glu + B27His 575% and 511%, while B9Asp + B27Glu showed 29% and 18% and the B25Asp analogue only 0.12% and 0.05% potency. Bioassays in mice or rabbits of the analogues except B25Asp showed that they had the same in vivo potency as human insulin 1.00 IU = 6.00 nmol. Thus the variation had the same in vivo potency as human insulin 1.00 IU = 6.00 nmol. Thus the variation in in vivo potency reflects the differences in receptor binding affinity. Relative to human insulin a low concentration is sufficient for a high affinity analogue to produce a given receptor complex formation and metabolic response. In conclusion, human insulin and analogues with markedly different in vitro potencies were equipotent in terms of hypoglycaemic effect. This is in agreement with the concept that elimination of insulin from blood and its subsequent degradation is mediated by insulin receptors.

  9. Case history of natural analogue research on sandstone type uranium occurrences, Japan

    International Nuclear Information System (INIS)

    Sakamaki, Y.; Kanai, Y.

    1991-01-01

    Previous fundamental studies on the ore genesis of uranium occurrences chiefly in Cenozoic sandstone formations in Japan, have been re-examined as the case history on natural analogue of radionuclides in high-level radioactive wastes (HLRW). Two principal mode of occurrences have been distinguished among Cenozoic uranium localities in Japan. In the Setouchi (Inland Sea) subregion, hot-spots are found in lacustrine to shallow sea facies of calm environment, corresponding to the first stage of formation of tectonic basins. As observed in Ningyo-toge and Tono area, stratabound ore bodies are generally arranged into paleo-channels. Another type of sporadic uranium indications are found within collapse basins in the 'Green-tuff' subregion, where intense volcanisms and block movements had been taken places throughout Middle miocene age. Well-developed fractures were to be favorable paths for uraniferous groundwater, as well as the suitable site for deposition of uranium. In both cases, the source material of uranium is granitic basement. Under oxidizing environment, uranium anomalies have been occasionally detected in surface- or fracture waters which passing through decomposed granite. In contrast to the behavior of uranium, one of the adequate analogues for mobile nuclides, thorium and REE are relatively immobile even under the same geologic and geochemical circumstances. In ore horizon, where reducing condition has still been kept, geochronological age of tetravalent uranium mineral is in concordance with the age of the host rock. Analysis of structural control shows that the principal factors for uranium concentration are the layout of redox front related to paleo-water tables. 234U/238U disequilibrium method has been proved to be the powerful tool for detecting mobility of uranium in the host rock throughout diagenesis and weathering process. The result of field and laboratory works on this is reported as an example. (author)

  10. Linking animals aloft with the terrestrial landscape

    Science.gov (United States)

    Buler, Jeffrey J.; Barrow, Wylie; Boone, Matthew; Dawson, Deanna K.; Diehl, Robert H.; Moore, Frank R.; Randall, Lori A.; Schreckengost, Timothy; Smolinsky, Jaclyn A.

    2018-01-01

    Despite using the aerosphere for many facets of their life, most flying animals (i.e., birds, bats, some insects) are still bound to terrestrial habitats for resting, feeding, and reproduction. Comprehensive broad-scale observations by weather surveillance radars of animals as they leave terrestrial habitats for migration or feeding flights can be used to map their terrestrial distributions either as point locations (e.g., communal roosts) or as continuous surface layers (e.g., animal densities in habitats across a landscape). We discuss some of the technical challenges to reducing measurement biases related to how radars sample the aerosphere and the flight behavior of animals. We highlight a recently developed methodological approach that precisely and quantitatively links the horizontal spatial structure of birds aloft to their terrestrial distributions and provides novel insights into avian ecology and conservation across broad landscapes. Specifically, we present case studies that (1) elucidate how migrating birds contend with crossing ecological barriers and extreme weather events, (2) identify important stopover areas and habitat use patterns of birds along their migration routes, and (3) assess waterfowl response to wetland habitat management and restoration. These studies aid our understanding of how anthropogenic modification of the terrestrial landscape (e.g., urbanization, habitat management), natural geographic features, and weather (e.g., hurricanes) can affect the terrestrial distributions of flying animals.

  11. Prussian Blue Analogues of Reduced Dimensionality

    NARCIS (Netherlands)

    Gengler, Regis Y. N.; Toma, Luminita M.; Pardo, Emilio; Lloret, Francesc; Ke, Xiaoxing; Van Tendeloo, Gustaaf; Gournis, Dimitrios; Rudolf, Petra

    2012-01-01

    Mixed-valence polycyanides (Prussian Blue analogues) possess a rich palette of properties spanning from room-temperature ferromagnetism to zero thermal expansion, which can be tuned by chemical modifications or the application of external stimuli (temperature, pressure, light irradiation). While

  12. Education in astronomy and solar-terrestrial relations in science research environment

    Science.gov (United States)

    Stoeva, Penka; Stoev, Alexey

    In recent years, more and more attention is paid to educational programmes, which are closely connected with the process of scientific research. Such programmes are developed in collab-oration and included in the schools, universities and scientific institutes in Bulgaria. They are also used in the organization of public events aimed to demonstrate beauty, relevance and significance of Space and Earth science to the whole world. During the last four years, So-lar-Terrestrial Influences Institute of the Bulgarian Academy of Sciences, and the Yuri Gagarin Public Astronomical Observatory and Planetarium, Stara Zagora succeeded to build an ex-cellent partnership, working on the International Heliophysical year and International Year of Astronomy -global efforts initiated by the UNESCO and the International Astronomical Union (IAU) to help the citizens of the world rediscover their place in the Universe. They organized and tutored all the Astronomical Observatories and Planetaria, and teachers from all around Bulgaria to participate in the world initiatives Solar Week, Sun-Earth Day,Yuri's Night, World Astronomy day and World Space week, and use them in the process of education and public outreach. After the official closing of the International Heliophysical year, the IHY follow-on activities in Bulgaria continued and were devoted to the International Year of Astronomy 2009. A lot of lectures, public talks and exhibitions have been organized. Stara Zagora became a host of IHY Space Weather Monitor -SID (Sudden Ionospheric Disturbances), numerous of educational materials have been adapted and translated in Bulgarian. Cycle of lectures "Epock of Great astronomical discoveries", devoted to the International Year of Astronomy was given in April 2009 in the Stara Zagora Art Gallery. Participation in the cornerstone projects of the International Year of Astronomy 2009 was organized: "100 hours of Astronomy" -ob-servations with small telescopes in the period of 5 -9 April

  13. The decadal state of the terrestrial carbon cycle : Global retrievals of terrestrial carbon allocation, pools, and residence times

    NARCIS (Netherlands)

    Bloom, A Anthony; Exbrayat, Jean-François; van der Velde, Ivar R; Feng, Liang; Williams, Mathew

    2016-01-01

    The terrestrial carbon cycle is currently the least constrained component of the global carbon budget. Large uncertainties stem from a poor understanding of plant carbon allocation, stocks, residence times, and carbon use efficiency. Imposing observational constraints on the terrestrial carbon cycle

  14. Effect of terrestrial radiation on brightness temperature at lunar nearside: Based on theoretical calculation and data analysis

    Science.gov (United States)

    Wei, Guangfei; Li, Xiongyao; Wang, Shijie

    2015-02-01

    Terrestrial radiation is another possible source of heat in lunar thermal environment at its nearside besides the solar illumination. On the basis of Clouds and the Earth's Radiant Energy System (CERES) data products, the effect of terrestrial radiation on the brightness temperature (TBe) of the lunar nearside has been theoretically calculated. It shows that the mafic lunar mare with high TBe is more sensitive to terrestrial radiation than the feldspathic highland with low TBe value. According to the synchronous rotation of the Moon, we extract TBe on lunar nearside using the microwave radiometer data from the first Chinese lunar probe Chang'E-1 (CE-1). Consistently, the average TBe at Mare Serenitatis is about 1.2 K while the highland around the Geber crater (19.4°S, 13.9°E) is relatively small at ∼0.4 K. Our results indicate that there is no significant effect of terrestrial radiation on TBe at the lunar nearside. However, to extract TBe accurately, effects of heat flow, rock abundance and subsurface rock fragments which are more significant should be considered in the future work.

  15. Receptor-isoform-selective insulin analogues give tissue-preferential effects

    DEFF Research Database (Denmark)

    Vienberg, Sara Gry; Bouman, Stephan D; Sørensen, Heidi

    2011-01-01

    The relative expression patterns of the two IR (insulin receptor) isoforms, +/- exon 11 (IR-B/IR-A respectively), are tissue-dependent. Therefore we have developed insulin analogues with different binding affinities for the two isoforms to test whether tissue-preferential biological effects can...... be attained. In rats and mice, IR-B is the most prominent isoform in the liver (> 95%) and fat (> 90%), whereas in muscles IR-A is the dominant isoform (> 95%). As a consequence, the insulin analogue INS-A, which has a higher relative affinity for human IR-A, had a higher relative potency [compared with HI...... (human insulin)] for glycogen synthesis in rat muscle strips (26%) than for glycogen accumulation in rat hepatocytes (5%) and for lipogenesis in rat adipocytes (4%). In contrast, the INS-B analogue, which has an increased affinity for human IR-B, had higher relative potencies (compared with HI...

  16. The Valles natural analogue project

    International Nuclear Information System (INIS)

    Stockman, H.; Krumhansl, J.; Ho, C.; McConnell, V.

    1994-12-01

    The contact between an obsidian flow and a steep-walled tuff canyon was examined as an analogue for a highlevel waste repository. The analogue site is located in the Valles Caldera in New Mexico, where a massive obsidian flow filled a paleocanyon in the Battleship Rock tuff. The obsidian flow provided a heat source, analogous to waste panels or an igneous intrusion in a repository, and caused evaporation and migration of water. The tuff and obsidian samples were analyzed for major and trace elements and mineralogy by INAA, XRF, X-ray diffraction; and scanning electron microscopy and electron microprobe. Samples were also analyzed for D/H and 39 Ar/ 4O isotopic composition. Overall,the effects of the heating event seem to have been slight and limited to the tuff nearest the contact. There is some evidence of devitrification and migration of volatiles in the tuff within 10 meters of the contact, but variations in major and trace element chemistry are small and difficult to distinguish from the natural (pre-heating) variability of the rocks

  17. Effects of Cu Pollution on the Expansion of an Amphibious Clonal Herb in Aquatic-Terrestrial Ecotones.

    Directory of Open Access Journals (Sweden)

    Liang Xu

    Full Text Available Physiological integration can enhance the performance of clonal plants in aquatic and terrestrial heterogeneous habitats and associated ecotones. Similar to nutrients, pollutants may be transported among connected ramets via physiological integration. Few studies have examined the expansion of amphibious clonal plants from terrestrial to aquatic environments, particularly when the local water supply is polluted with heavy metals. A greenhouse experiment was conducted using the amphibious plant Alternanthera philoxeroides to determine whether Cu can spread among clonal plants and examine the corresponding effects of this pollution on the expansion of clonal plants in aquatic-terrestrial ecotones. Ramets from the same clonal fragments were rooted in unpolluted soil and polluted water at five different levels. The responses of the ramets in terrestrial and aquatic habitats were quantified via traits associated with growth, morphology and Cu accumulation. The results indicated that ramets in soil and water significantly differed in nearly all of these traits. The expansion of populations from terrestrial to polluted aquatic habitats was facilitated by stem elongation rather than new ramet production. The accumulated Cu in polluted ramets can be horizontally transported to other ramets in soil via connected stolons. In terms of clonal growth patterns, variations in Cu pollution intensity were negatively correlated with variations in the morphological and growth traits of ramets in polluted aquatic habitats and unpolluted soil. We concluded that Cu ions are distributed among the clones and accumulated in different ramet tissues in heterogeneous habitats. Therefore, we suggest that Cu pollution of aquatic-terrestrial ecotones, especially at high levels, can affect the growth and expansion of the whole clones because Cu ions are shared between integrated ramets.

  18. Effects of Cu Pollution on the Expansion of an Amphibious Clonal Herb in Aquatic-Terrestrial Ecotones.

    Science.gov (United States)

    Xu, Liang; Zhou, Zhen-Feng

    2016-01-01

    Physiological integration can enhance the performance of clonal plants in aquatic and terrestrial heterogeneous habitats and associated ecotones. Similar to nutrients, pollutants may be transported among connected ramets via physiological integration. Few studies have examined the expansion of amphibious clonal plants from terrestrial to aquatic environments, particularly when the local water supply is polluted with heavy metals. A greenhouse experiment was conducted using the amphibious plant Alternanthera philoxeroides to determine whether Cu can spread among clonal plants and examine the corresponding effects of this pollution on the expansion of clonal plants in aquatic-terrestrial ecotones. Ramets from the same clonal fragments were rooted in unpolluted soil and polluted water at five different levels. The responses of the ramets in terrestrial and aquatic habitats were quantified via traits associated with growth, morphology and Cu accumulation. The results indicated that ramets in soil and water significantly differed in nearly all of these traits. The expansion of populations from terrestrial to polluted aquatic habitats was facilitated by stem elongation rather than new ramet production. The accumulated Cu in polluted ramets can be horizontally transported to other ramets in soil via connected stolons. In terms of clonal growth patterns, variations in Cu pollution intensity were negatively correlated with variations in the morphological and growth traits of ramets in polluted aquatic habitats and unpolluted soil. We concluded that Cu ions are distributed among the clones and accumulated in different ramet tissues in heterogeneous habitats. Therefore, we suggest that Cu pollution of aquatic-terrestrial ecotones, especially at high levels, can affect the growth and expansion of the whole clones because Cu ions are shared between integrated ramets.

  19. Aspartame and Its Analogues

    Science.gov (United States)

    Pavlova, L. A.; Komarova, T. V.; Davidovich, Yurii A.; Rogozhin, S. V.

    1981-04-01

    The results of studies on the biochemistry of the sweet taste are briefly reviewed. The methods of synthesis of "aspartame" — a sweet dipeptide — are considered, its structural analogues are described, and quantitative estimates are made of the degree of sweetness relative to sucrose. Attention is concentrated mainly on problems of the relation between the structure of the substance and its taste in the series of aspartyl derivatives. The bibliography includes 118 references.

  20. The Influence of Pseudomonas fluorescens on Corrosion Products of Archaeological Tin-Bronze Analogues

    Science.gov (United States)

    Ghiara, G.; Grande, C.; Ferrando, S.; Piccardo, P.

    2018-01-01

    In this study, tin-bronze analogues of archaeological objects were investigated in the presence of an aerobic Pseudomonas fluorescens strain in a solution, containing chlorides, sulfates, carbonates and nitrates according to a previous archaeological characterization. Classical fixation protocols were employed in order to verify the attachment capacity of such bacteria. In addition, classical metallurgical analytical techniques were used to detect the effect of bacteria on the formation of uncommon corrosion products in such an environment. Results indicate quite a good attachment capacity of the bacteria to the metallic surface and the formation of the uncommon corrosion products sulfates and sulfides is probably connected to the bacterial metabolism.

  1. Analogue studies at the french atomic commission (CEA)

    International Nuclear Information System (INIS)

    Petit, J.C.

    1986-06-01

    The different research activities of the French Atomic Energy Commission in the analogue study field are presented. Most of them are conducted in collaboration with major research organisations, both french and international. In fact, the scientific community has been associated to these programmes at different steps of their realisation. The brief description presented illustrates the great diversity and complementarity of actions conducted by CEA for better understanding, through the study of natural analogues, the basic processes that will rule the long term behaviour of high level radwaste materials in a repository and hence contributing to hopefully guaranty disposal safety

  2. Comparative Climatology of Terrestrial Planets

    Science.gov (United States)

    Mackwell, Stephen J.; Simon-Miller, Amy A.; Harder, Jerald W.; Bullock, Mark A.

    Public awareness of climate change on Earth is currently very high, promoting significant interest in atmospheric processes. We are fortunate to live in an era where it is possible to study the climates of many planets, including our own, using spacecraft and groundbased observations as well as advanced computational power that allows detailed modeling. Planetary atmospheric dynamics and structure are all governed by the same basic physics. Thus differences in the input variables (such as composition, internal structure, and solar radiation) among the known planets provide a broad suite of natural laboratory settings for gaining new understanding of these physical processes and their outcomes. Diverse planetary settings provide insightful comparisons to atmospheric processes and feedbacks on Earth, allowing a greater understanding of the driving forces and external influences on our own planetary climate. They also inform us in our search for habitable environments on planets orbiting distant stars, a topic that was a focus of Exoplanets, the preceding book in the University of Arizona Press Space Sciences Series. Quite naturally, and perhaps inevitably, our fascination with climate is largely driven toward investigating the interplay between the early development of life and the presence of a suitable planetary climate. Our understanding of how habitable planets come to be begins with the worlds closest to home. Venus, Earth, and Mars differ only modestly in their mass and distance from the Sun, yet their current climates could scarcely be more divergent. Our purpose for this book is to set forth the foundations for this emerging science and to bring to the forefront our current understanding of atmospheric formation and climate evolution. Although there is significant comparison to be made to atmospheric processes on nonterrestrial planets in our solar system — the gas and ice giants — here we focus on the terrestrial planets, leaving even broader comparisons

  3. Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production

    Directory of Open Access Journals (Sweden)

    Maarten Walmagh

    2015-06-01

    Full Text Available Trehalose (α-d-glucopyranosyl α-d-glucopyranoside is a non-reducing sugar with unique stabilizing properties due to its symmetrical, low energy structure consisting of two 1,1-anomerically bound glucose moieties. Many applications of this beneficial sugar have been reported in the novel food (nutricals, medical, pharmaceutical and cosmetic industries. Trehalose analogues, like lactotrehalose (α-d-glucopyranosyl α-d-galactopyranoside or galactotrehalose (α-d-galactopyranosyl α-d-galactopyranoside, offer similar benefits as trehalose, but show additional features such as prebiotic or low-calorie sweetener due to their resistance against hydrolysis during digestion. Unfortunately, large-scale chemical production processes for trehalose analogues are not readily available at the moment due to the lack of efficient synthesis methods. Most of the procedures reported in literature suffer from low yields, elevated costs and are far from environmentally friendly. “Greener” alternatives found in the biocatalysis field, including galactosidases, trehalose phosphorylases and TreT-type trehalose synthases are suggested as primary candidates for trehalose analogue production instead. Significant progress has been made in the last decade to turn these into highly efficient biocatalysts and to broaden the variety of useful donor and acceptor sugars. In this review, we aim to provide an overview of the latest insights and future perspectives in trehalose analogue chemistry, applications and production pathways with emphasis on biocatalysis.

  4. Superconductive analogue of spin glasses

    International Nuclear Information System (INIS)

    Feigel'man, M.; Ioffe, L.; Vinokur, V.; Larkin, A.

    1987-07-01

    The properties of granular superconductors in magnetic fields, namely the existence of a new superconductive state analogue of the low-temperature superconductive state in spin glasses are discussed in the frame of the infinite-range model and the finite-range models. Experiments for elucidation of spin-glass superconductive state in real systems are suggested. 30 refs

  5. Neurochemical binding profiles of novel indole and benzofuran MDMA analogues.

    Science.gov (United States)

    Shimshoni, Jakob A; Winkler, Ilan; Golan, Ezekiel; Nutt, David

    2017-01-01

    3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical trials. In the present study, we have characterized the neurochemical binding profiles of three MDMA-benzofuran analogues (1-(benzofuran-5-yl)-propan-2-amine, 5-APB; 1-(benzofuran-6-yl)-N-methylpropan-2-amine, 6-MAPB; 1-(benzofuran-5-yl)-N-methylpropan-2-amine, 5-MAPB) and one MDMA-indole analogue (1-(1H-indol-5-yl)-2-methylamino-propan-1-ol, 5-IT). These compounds were screened as potential second-generation anti-PTSD drugs, against a battery of human and non-human receptors, transporters, and enzymes, and their potencies as 5-HT 2 receptor agonist and monoamine uptake inhibitors determined. All MDMA analogues displayed high binding affinities for 5-HT 2a,b,c and NE α2 receptors, as well as significant 5-HT, DA, and NE uptake inhibition. 5-APB revealed significant agonist activity at the 5-HT 2a,b,c receptors, while 6-MAPB, 5-MAPB, and 5-IT exhibited significant agonist activity at the 5-HT 2c receptor. There was a lack of correlation between the results of functional uptake and the monoamine transporter binding assay. MDMA analogues emerged as potent and selective monoamine oxidase A inhibitors. Based on 6-MAPB favorable pharmacological profile, it was further subjected to IC 50 determination for monoamine transporters. Overall, all MDMA analogues displayed higher monoamine receptor/transporter binding affinities and agonist activity at the 5-HT 2a,c receptors as compared to MDMA.

  6. The Algebra of a q-Analogue of Multiple Harmonic Series

    Directory of Open Access Journals (Sweden)

    Yoshihiro Takeyama

    2013-10-01

    Full Text Available We introduce an algebra which describes the multiplication structure of a family of q-series containing a q-analogue of multiple zeta values. The double shuffle relations are formulated in our framework. They contain a q-analogue of Hoffman's identity for multiple zeta values. We also discuss the dimension of the space spanned by the linear relations realized in our algebra.

  7. Naturally occurring crystalline phases: analogues for radioactive waste forms

    International Nuclear Information System (INIS)

    Haaker, R.F.; Ewing, R.C.

    1981-01-01

    Naturally occurring mineral analogues to crystalline phases that are constituents of crystalline radioactive waste forms provide a basis for comparison by which the long-term stability of these phases may be estimated. The crystal structures and the crystal chemistry of the following natural analogues are presented: baddeleyite, hematite, nepheline; pollucite, scheelite;sodalite, spinel, apatite, monazite, uraninite, hollandite-priderite, perovskite, and zirconolite. For each phase in geochemistry, occurrence, alteration and radiation effects are described. A selected bibliography for each phase is included

  8. Naturally occurring crystalline phases: analogues for radioactive waste forms

    Energy Technology Data Exchange (ETDEWEB)

    Haaker, R.F.; Ewing, R.C.

    1981-01-01

    Naturally occurring mineral analogues to crystalline phases that are constituents of crystalline radioactive waste forms provide a basis for comparison by which the long-term stability of these phases may be estimated. The crystal structures and the crystal chemistry of the following natural analogues are presented: baddeleyite, hematite, nepheline; pollucite, scheelite;sodalite, spinel, apatite, monazite, uraninite, hollandite-priderite, perovskite, and zirconolite. For each phase in geochemistry, occurrence, alteration and radiation effects are described. A selected bibliography for each phase is included.

  9. Sex ratio variation in the bumblebee Bombus terrestris

    DEFF Research Database (Denmark)

    Duchateau, Marie José; Velthuis, Hayo H. W.; Boomsma, Jacobus Jan

    2004-01-01

    Bombus terrestris, bumblebees, colony development, queen control, reproductive strategies, sex allocation......Bombus terrestris, bumblebees, colony development, queen control, reproductive strategies, sex allocation...

  10. Terrestrial nitrogen-carbon cycle interactions at the global scale.

    Science.gov (United States)

    Zaehle, S

    2013-07-05

    Interactions between the terrestrial nitrogen (N) and carbon (C) cycles shape the response of ecosystems to global change. However, the global distribution of nitrogen availability and its importance in global biogeochemistry and biogeochemical interactions with the climate system remain uncertain. Based on projections of a terrestrial biosphere model scaling ecological understanding of nitrogen-carbon cycle interactions to global scales, anthropogenic nitrogen additions since 1860 are estimated to have enriched the terrestrial biosphere by 1.3 Pg N, supporting the sequestration of 11.2 Pg C. Over the same time period, CO2 fertilization has increased terrestrial carbon storage by 134.0 Pg C, increasing the terrestrial nitrogen stock by 1.2 Pg N. In 2001-2010, terrestrial ecosystems sequestered an estimated total of 27 Tg N yr(-1) (1.9 Pg C yr(-1)), of which 10 Tg N yr(-1) (0.2 Pg C yr(-1)) are due to anthropogenic nitrogen deposition. Nitrogen availability already limits terrestrial carbon sequestration in the boreal and temperate zone, and will constrain future carbon sequestration in response to CO2 fertilization (regionally by up to 70% compared with an estimate without considering nitrogen-carbon interactions). This reduced terrestrial carbon uptake will probably dominate the role of the terrestrial nitrogen cycle in the climate system, as it accelerates the accumulation of anthropogenic CO2 in the atmosphere. However, increases of N2O emissions owing to anthropogenic nitrogen and climate change (at a rate of approx. 0.5 Tg N yr(-1) per 1°C degree climate warming) will add an important long-term climate forcing.

  11. Design, Synthesis and Cytotoxic Evaluation of o-Carboxamido Stilbene Analogues

    Directory of Open Access Journals (Sweden)

    Mohamad Nurul Azmi

    2013-11-01

    Full Text Available Resveratrol, a natural stilbene found in grapes and wines exhibits a wide range of pharmacological properties. Resveratrol is also known as a good chemopreventive agent for inhibiting carcinogenesis processes that target kinases, cyclooxygenases, ribonucleotide reductase and DNA polymerases. A total of 19 analogues with an amide moiety were synthesized and the cytotoxic effects of the analogues on a series of human cancer cell lines are reported. Three compounds 6d, 6i and 6n showed potent cytotoxicity against prostate cancer DU-145 (IC50 = 16.68 µM, colon cancer HT-29 (IC50 = 7.51 µM and breast cancer MCF-7 (IC50 = 21.24 µM, respectively, which are comparable with vinblastine. The resveratrol analogues were synthesized using the Heck method.

  12. Priapism caused by 'Tribulus terrestris'.

    Science.gov (United States)

    Campanelli, M; De Thomasis, R; Tenaglia, R L

    2016-01-01

    A 36-year-old Caucasian man was diagnosed with a 72-h-lasting priapism that occurred after the assumption of a Herbal supplement based on Tribulus terrestris, which is becoming increasingly popular for the treatment of sexual dysfunction. The patient underwent a cavernoglandular shunt (Ebbehoj shunt) in order to obtain complete detumescence, from which derived negative post-episode outcomes on sexual function. All patients consuming non-FDA-approved alternative supplements such as Tribulus terrestris should be warned about the possible serious side effects.

  13. Monitoring of radionuclides in the terrestrial and aquatic environment of the nuclear power plant at Barsebaeck (Sweden) for the period 1984-1991

    International Nuclear Information System (INIS)

    Neumann, G.

    1994-01-01

    This report summarizes the main results from the environment monitoring sampling for the years 1984-1991 around the nuclear power plant at Barsebaeck, southern Sweden. The sampling are required according to the environment monitoring programme which has been decided upon by the Swedish Radiation Protection Inst. Terrestrial samples include cultivated plants, natural vegetation, milk, some other foods of animal origin and sludge. From the aquatic environment, samples of sea water, bottom sediments, benthic fauna, algae and fish are collected. This report accounts for all samples that have been measured during the period 1984-1991. The diagrams also include data from the years 1981-1983. The annual discharge to air and to water resulted during the years 1984-1991 in a dose commitment to a critical group which generally amounted to less than 2 micro-sievert (which equals 2 per cent of the maximum permitted, viz. one Norm release). The annual radiation dose outside the power plant has always been found less than 0.2% of that from the background radiation. Outside the plant, only very small quantities of radionuclides were detected which could be related to its operation. Radionuclides from the power plant have not with certainty been detected in cultivated plants, milk, and meat produced in the vicinity of the power plant. On the other hand small quantities of Co-60 and Zn-65 from the plant were detected in, for instance, some samples of eel and cod from stations close to the plant. In 1985 and 1989, special sediment sampling were carried out at 12 stations off Barsebaeck. One aim was to investigate whether any accumulation of radionuclides from Barsebaeck in bottom sediments had occurred during the period. There was no clear evidence of any such accumulation. 15 refs, 22 figs, 16 tabs

  14. Plastic Bag Derived-Microplastics as a Vector for Metal Exposure in Terrestrial Invertebrates.

    Science.gov (United States)

    Hodson, Mark E; Duffus-Hodson, Calum A; Clark, Andy; Prendergast-Miller, Miranda T; Thorpe, Karen L

    2017-04-18

    Microplastics are widespread contaminants in terrestrial environments but comparatively little is known about interactions between microplastics and common terrestrial contaminants such as zinc (Zn). In adsorption experiments fragmented HDPE bags c. one mm 2 in size showed similar sorption characteristics to soil. However, when present in combination with soil, concentrations of adsorbed Zn on a per mass basis were over an order of magnitude lower on microplastics. Desorption of the Zn was minimal from both microplastics and soil in synthetic soil solution (0.01 M CaCl 2 ), but in synthetic earthworm guts desorption was higher from microplastics (40-60%) than soil (2-15%), suggesting microplastics could increase Zn bioavailability. Individual Lumbricus terrestris earthworms exposed for 28 days in mesocosms of 260 g moist soil containing 0.35 wt % of Zn-bearing microplastic (236-4505 mg kg -1 ) ingested the microplastics, but there was no evidence of Zn accumulation, mortality, or weight change. Digestion of the earthworms showed that they did not retain microplastics in their gut. These findings indicate that microplastics could act as vectors to increase metal exposure in earthworms, but that the associated risk is unlikely to be significant for essential metals such as Zn that are well regulated by metabolic processes.

  15. THE PENA BLANCA NATURAL ANALOGUE PERFORMANCE ASSESSMENT MODEL

    Energy Technology Data Exchange (ETDEWEB)

    G. Saulnier and W. Statham

    2006-04-16

    The Nopal I uranium mine in the Sierra Pena Blanca, Chihuahua, Mexico serves as a natural analogue to the Yucca Mountain repository. The Pena Blanca Natural Analogue Performance Assessment Model simulates the mobilization and transport of radionuclides that are released from the mine and transported to the saturated zone. The Pena Blanca Natural Analogue Performance Assessment Model uses probabilistic simulations of hydrogeologic processes that are analogous to the processes that occur at the Yucca Mountain site. The Nopal I uranium deposit lies in fractured, welded, and altered rhyolitic ash-flow tuffs that overlie carbonate rocks, a setting analogous to the geologic formations at the Yucca Mountain site. The Nopal I mine site has the following analogous characteristics as compared to the Yucca Mountain repository site: (1) Analogous source--UO{sub 2} uranium ore deposit = spent nuclear fuel in the repository; (2) Analogous geology--(i.e. fractured, welded, and altered rhyolitic ash-flow tuffs); (3) Analogous climate--Semiarid to arid; (4) Analogous setting--Volcanic tuffs overlie carbonate rocks; and (5) Analogous geochemistry--Oxidizing conditions Analogous hydrogeology: The ore deposit lies in the unsaturated zone above the water table.

  16. THE PENA BLANCA NATURAL ANALOGUE PERFORMANCE ASSESSMENT MODEL

    International Nuclear Information System (INIS)

    G. Saulnier; W. Statham

    2006-01-01

    The Nopal I uranium mine in the Sierra Pena Blanca, Chihuahua, Mexico serves as a natural analogue to the Yucca Mountain repository. The Pena Blanca Natural Analogue Performance Assessment Model simulates the mobilization and transport of radionuclides that are released from the mine and transported to the saturated zone. The Pena Blanca Natural Analogue Performance Assessment Model uses probabilistic simulations of hydrogeologic processes that are analogous to the processes that occur at the Yucca Mountain site. The Nopal I uranium deposit lies in fractured, welded, and altered rhyolitic ash-flow tuffs that overlie carbonate rocks, a setting analogous to the geologic formations at the Yucca Mountain site. The Nopal I mine site has the following analogous characteristics as compared to the Yucca Mountain repository site: (1) Analogous source--UO 2 uranium ore deposit = spent nuclear fuel in the repository; (2) Analogous geology--(i.e. fractured, welded, and altered rhyolitic ash-flow tuffs); (3) Analogous climate--Semiarid to arid; (4) Analogous setting--Volcanic tuffs overlie carbonate rocks; and (5) Analogous geochemistry--Oxidizing conditions Analogous hydrogeology: The ore deposit lies in the unsaturated zone above the water table

  17. Transdermal delivery of a melanotropic peptide hormone analogue

    International Nuclear Information System (INIS)

    Dawson, B.V.; Hadley, M.E.; Kreutzfeld, K.; Dorr, R.T.; Hruby, V.J.; Al-Obeidi, F.; Don, S.

    1988-01-01

    We previously reported that topical application of [Nl3 4 ,D-Phe 7 ]alpha-MSH, a superpotent analogue of alpha-melanocyte stimulating hormone, to mice induces a darkening of follicular melanocytes throughout the skin. We now report that the melanotropin analogue can be delivered across mouse but not rat skin in an in vitro model system. Passage of the analogue from the topically applied vehicle (polyethylene glycol) across the skin into a subcutaneous receiving vessel was demonstrated by both bioassay as well as by radioimmunoassay. The bioassay data demonstrate that percutaneous absorption of the melanotropin did not result in loss of biological activity of the peptide. The differential penetration of the peptide across rodent skin reveals that one cannot predict percutaneous absorption of a substance across the stratum corneum from studies on a single species. The present results are the first to demonstrate, by direct quantitative measurements, that a bioactive peptide can be delivered across the vertebrate integument in vitro. These studies point out the potential of a topically applied melanotropin for tanning of the skin and possibly for treatment of certain hypopigmentary disorders

  18. Manipulating lightcone fluctuations in an analogue cosmic string

    Directory of Open Access Journals (Sweden)

    Jiawei Hu

    2018-02-01

    Full Text Available We study the flight time fluctuations in an anisotropic medium inspired by a cosmic string with an effective fluctuating refractive index caused by fluctuating vacuum electric fields, which are analogous to the lightcone fluctuations due to fluctuating spacetime metric when gravity is quantized. The medium can be realized as a metamaterial that mimics a cosmic string in the sense of transformation optics. For a probe light close to the analogue string, the flight time variance is ν times that in a normal homogeneous and isotropic medium, where ν is a parameter characterizing the deficit angle of the spacetime of a cosmic string. The parameter ν, which is always greater than unity for a real cosmic string, is determined by the dielectric properties of the metamaterial for an analogue string. Therefore, the flight time fluctuations of a probe light can be manipulated by changing the electric permittivity and magnetic permeability of the analogue medium. We argue that it seems possible to fabricate a metamaterial that mimics a cosmic string with a large ν in laboratory so that a currently observable flight time variance might be achieved.

  19. Natural analogue studies as supplements to biomineralization research

    International Nuclear Information System (INIS)

    McNeil, M.B.

    1995-01-01

    Chemical reactions can alter the chemistry and crystal structure of solid objects over archeological or geological times, while preserving external physical shapes. The reactions resulting in these structures offer natural analogues to laboratory experiments in biomineralization and to biologically influenced alteration of nuclear waste packages, and thus, they offer the only available way of validating models that purport waste package behavior over archaeological or geological times. Potential uses of such analogues in the construction and validation of hypothetical mechanisms of microbiological corrosion and biomineralization are reviewed. Evidence from such analogues suggests that biofilms can control materials alteration in ways usually overlooked. The newly hypothesized mechanisms involve control by biofilms of the cation flow near the solid surface and offer plausible mechanisms for the formation of mixed-cation minerals under conditions that would lead to dealloying in abiotic experiments; they also account for the formation of unusual minerals [such as posnjakite, Cu 4 SO 4 (OH) 6· H 2 O] and mineral morphologies unusual in corrosion [malachite, Cu 2 CO 3 (OH) 2 , rarely forms botryoidally under corrosion conditions and its occasional presence on archaeological objects that appear to have undergone microbiological corrosion may be related to biofilm phenomena

  20. Manipulating lightcone fluctuations in an analogue cosmic string

    Science.gov (United States)

    Hu, Jiawei; Yu, Hongwei

    2018-02-01

    We study the flight time fluctuations in an anisotropic medium inspired by a cosmic string with an effective fluctuating refractive index caused by fluctuating vacuum electric fields, which are analogous to the lightcone fluctuations due to fluctuating spacetime metric when gravity is quantized. The medium can be realized as a metamaterial that mimics a cosmic string in the sense of transformation optics. For a probe light close to the analogue string, the flight time variance is ν times that in a normal homogeneous and isotropic medium, where ν is a parameter characterizing the deficit angle of the spacetime of a cosmic string. The parameter ν, which is always greater than unity for a real cosmic string, is determined by the dielectric properties of the metamaterial for an analogue string. Therefore, the flight time fluctuations of a probe light can be manipulated by changing the electric permittivity and magnetic permeability of the analogue medium. We argue that it seems possible to fabricate a metamaterial that mimics a cosmic string with a large ν in laboratory so that a currently observable flight time variance might be achieved.

  1. Predictors of Behavior and Performance in Extreme Environments: The Antarctic Space Analogue Program

    Science.gov (United States)

    Palinkas, Lawrence A.; Gunderson, E K. Eric; Holland, A. W.; Miller, Christopher; Johnson, Jeffrey C.

    2000-01-01

    To determine which, if any, characteristics should be incorporated into a select-in approach to screening personnel for long-duration spaceflight, we examined the influence of crewmember social/ demographic characteristics, personality traits, interpersonal needs, and characteristics of station physical environments on performance measures in 657 American men who spent an austral winter in Antarctica between 1963 and 1974. During screening, subjects completed a Personal History Questionnaire which obtained information on social and demographic characteristics, the Deep Freeze Opinion Survey which assessed 5 different personality traits, and the Fundamental Interpersonal Relations Orientation-Behavior (FIRO-B) Scale which measured 6 dimensions of interpersonal needs. Station environment included measures of crew size and severity of physical environment. Performance was assessed on the basis of combined peer-supervisor evaluations of overall performance, peer nominations of fellow crewmembers who made ideal winter-over candidates, and self-reported depressive symptoms. Social/demographic characteristics, personality traits, interpersonal needs, and characteristics of station environments collectively accounted for 9-17% of the variance in performance measures. The following characteristics were significant independent predictors of more than one performance measure: military service, low levels of neuroticism, extraversion and conscientiousness, and a low desire for affection from others. These results represent an important first step in the development of select-in criteria for personnel on long-duration missions in space and other extreme environments. These criteria must take into consideration the characteristics of the environment and the limitations they place on meeting needs for interpersonal relations and task performance, as well as the characteristics of the individuals and groups who live and work in these environments.

  2. Pollen and spores of terrestrial plants

    Science.gov (United States)

    Bernhardt, Christopher E.; Willard, Debra A.; Shennan, Ian; Long, Antony J.; Horton, Benjamin P.

    2015-01-01

    Pollen and spores are valuable tools in reconstructing past sea level and climate because of their ubiquity, abundance, and durability as well as their reciprocity with source vegetation to environmental change (Cronin, 1999; Traverse, 2007; Willard and Bernhardt, 2011). Pollan is found in many sedimentary environments, from freshwater to saltwater, terrestrial to marine. It can be abundant in a minimal amount of sample material, for example half a gram, as concentrations can be as high as four million grains per gram (Traverse, 2007). The abundance of pollen in a sample lends it to robust statistical analysis for the quantitative reconstruction of environments. The outer cell wall is resistant to decay in sediments and allows palynomorphs (pollen and spores) to record changes in plant communities and sea level over millions of years. These characteristics make pollen and spores a powerful tool to use in sea-level research.This chapter describes the biology of pollen and spores and how they are transported and preserved in sediments. We present a methodology for isolating pollen from sediments and a general language and framework to identify pollen as well as light micrographs of a selection of common pollen grains, We then discuss their utility in sea-level research.

  3. Durable terrestrial bedrock predicts submarine canyon formation

    Science.gov (United States)

    Smith, Elliot; Finnegan, Noah J.; Mueller, Erich R.; Best, Rebecca J.

    2017-01-01

    Though submarine canyons are first-order topographic features of Earth, the processes responsible for their occurrence remain poorly understood. Potentially analogous studies of terrestrial rivers show that the flux and caliber of transported bedload are significant controls on bedrock incision. Here we hypothesize that coarse sediment load could exert a similar role in the formation of submarine canyons. We conducted a comprehensive empirical analysis of canyon occurrence along the West Coast of the contiguous United States which indicates that submarine canyon occurrence is best predicted by the occurrence of durable crystalline bedrock in adjacent terrestrial catchments. Canyon occurrence is also predicted by the flux of bed sediment to shore from terrestrial streams. Surprisingly, no significant correlation was observed between canyon occurrence and the slope or width of the continental shelf. These findings suggest that canyon incision is promoted by greater yields of durable terrestrial clasts to the shore.

  4. Optimization of gefitinib analogues with potent anticancer activity.

    Science.gov (United States)

    Yin, Kai-Hao; Hsieh, Yi-Han; Sulake, Rohidas S; Wang, Su-Pei; Chao, Jui-I; Chen, Chinpiao

    2014-11-15

    The interactions of gefitinib (Iressa) in EGFR are hydrogen bonding and van der Waals forces through quinazoline and aniline rings. However the morpholino group of gefitinib is poorly ordered due to its weak electron density. A series of novel piperazino analogues of gefitinib where morpholino group substituted with various piperazino groups were designed and synthesized. Most of them indicated significant anti-cancer activities against human cancer cell lines. In particular, compounds 52-54 showed excellent potency against cancer cells. Convergent synthetic approach has been developed for the synthesis of gefitinib intermediate which can lead to gefitinib as well as numerous analogues. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Tribulus terrestris Extract Improves Human Sperm Parameters In Vitro

    Science.gov (United States)

    Khaleghi, Sara; Bakhtiari, Mitra; Asadmobini, Atefeh; Esmaeili, Farzane

    2016-01-01

    Objective. The object of present study was to investigate the effects of direct addition of Tribulus terrestris extract on human sperm parameters. Design. Semen specimens from 40 healthy men volunteers were divided into 4 groups: one group received no treatment (control group) while the others were incubated with 20, 40, and 50 µg/mL of T terrestris extract (experimental groups). Motility, viability, and DNA fragmentation were assessed in all groups. Results. The incubation of human semen with 40 and 50 μg/mL of T terrestris extract significantly enhanced total sperm motility, number of progressive motile spermatozoa, and curvilinear velocity over 60 to 120 minutes’ holding time (P terrestris extract (P terrestris extract to human sperm could affect male fertility capacity. PMID:27694560

  6. Tribulus terrestris Extract Improves Human Sperm Parameters In Vitro.

    Science.gov (United States)

    Khaleghi, Sara; Bakhtiari, Mitra; Asadmobini, Atefeh; Esmaeili, Farzane

    2016-09-30

    The object of present study was to investigate the effects of direct addition of Tribulus terrestris extract on human sperm parameters. Semen specimens from 40 healthy men volunteers were divided into 4 groups: one group received no treatment (control group) while the others were incubated with 20, 40, and 50 µg/mL of T terrestris extract (experimental groups). Motility, viability, and DNA fragmentation were assessed in all groups. The incubation of human semen with 40 and 50 μg/mL of T terrestris extract significantly enhanced total sperm motility, number of progressive motile spermatozoa, and curvilinear velocity over 60 to 120 minutes' holding time (P terrestris extract (P terrestris extract to human sperm could affect male fertility capacity. © The Author(s) 2016.

  7. Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines.

    Directory of Open Access Journals (Sweden)

    Michelle Visagie

    Full Text Available 2-Methoxyestradiol (2ME2 is a naturally occurring estradiol metabolite which possesses antiproliferative, antiangiogenic and antitumor properties. However, due to its limited biological accessibility, synthetic analogues have been synthesized and tested in attempt to develop drugs with improved oral bioavailability and efficacy. The aim of this study was to evaluate the antiproliferative effects of three novel in silico-designed sulphamoylated 2ME2 analogues on the HeLa cervical adenocarcinoma cell line and estrogen receptor-negative breast adenocarcinoma MDA-MB-231 cells. A dose-dependent study (0.1-25 μM was conducted with an exposure time of 24 hours. Results obtained from crystal violet staining indicated that 0.5 μM of all 3 compounds reduced the number of cells to 50%. Lactate dehydrogenase assay was used to assess cytotoxicity, while the mitotracker mitochondrial assay and caspase-6 and -8 activity assays were used to investigate the possible occurrence of apoptosis. Tubulin polymerization assays were conducted to evaluate the influence of these sulphamoylated 2ME2 analogues on tubulin dynamics. Double immunofluorescence microscopy using labeled antibodies specific to tyrosinate and detyrosinated tubulin was conducted to assess the effect of the 2ME2 analogues on tubulin dynamics. An insignificant increase in the level of lactate dehydrogenase release was observed in the compounds-treated cells. These sulphamoylated compounds caused a reduction in mitochondrial membrane potential, cytochrome c release and caspase 3 activation indicating apoptosis induction by means of the intrinsic pathway in HeLa and MDA-MB-231 cells. Microtubule depolymerization was observed after exposure to these three sulphamoylated analogues.

  8. Difference in brain activations during appreciating paintings and photographic analogues

    Directory of Open Access Journals (Sweden)

    Yoshinori eMizokami

    2014-07-01

    Full Text Available Several studies have investigated neural correlates of aesthetic appreciation for paintings but to date the findings have been heterogeneous. This heterogeneity may be attributed to previous studies’ measurement of aesthetic appreciation of not only the beauty of paintings but also the beauty of motifs of the paintings. In order to better elucidate the beauty of paintings, it seems necessary to compare aesthetic appreciation of paintings and photographic analogues which included corresponding real images. We prepared for famous painters’ pictures and their photographic analogues which were set up to resemble each painting in order to investigate the hypothesis that there exist specific neural correlates associated with the aesthetic appreciation for paintings. Forty-four subjects participated in functional magnetic resonance study which required comparisons of aesthetic appreciation of paintings of still life and landscape versus photographic analogues including corresponding real images of still life and landscape. Bilateral cuneus and the left lingual gyrus were activated in the comparison of aesthetic appreciation of paintings versus photographic analogues. In conclusion, the present findings suggest a possibility of the existence of specific neural correlates associated with the aesthetic appreciation for paintings and that bilateral cuneus and the left lingual gyrus may be involved.

  9. Hepatoprotective and Antioxidant Activities of Tribulus Terrestris

    NARCIS (Netherlands)

    Harraz, Fathalla M; Ghazy, Nabila M; Hammoda, Hala M; Nafeaa, Abeer A.; Abdallah, Ingy I.

    2015-01-01

    Tribulus terrestris L. has been used in folk medicine throughout history. The present study examined the acute toxicity of the total ethanolic extract of T. Terrestris followed by investigation of the hepatoprotective activity of the total ethanolic extract and different fractions of the aerial

  10. Review of laboratory-based terrestrial bioaccumulation assessment approaches for organic chemicals: Current status and future possibilities.

    Science.gov (United States)

    Hoke, Robert; Huggett, Duane; Brasfield, Sandra; Brown, Becky; Embry, Michelle; Fairbrother, Anne; Kivi, Michelle; Paumen, Miriam Leon; Prosser, Ryan; Salvito, Dan; Scroggins, Rick

    2016-01-01

    In the last decade, interest has been renewed in approaches for the assessment of the bioaccumulation potential of chemicals, principally driven by the need to evaluate large numbers of chemicals as part of new chemical legislation, while reducing vertebrate test organism use called for in animal welfare legislation. This renewed interest has inspired research activities and advances in bioaccumulation science for neutral organic chemicals in aquatic environments. In January 2013, ILSI Health and Environmental Sciences Institute convened experts to identify the state of the science and existing shortcomings in terrestrial bioaccumulation assessment of neutral organic chemicals. Potential modifications to existing laboratory methods were identified, including areas in which new laboratory approaches or test methods could be developed to address terrestrial bioaccumulation. The utility of "non-ecotoxicity" data (e.g., mammalian laboratory data) was also discussed. The highlights of the workshop discussions are presented along with potential modifications in laboratory approaches and new test guidelines that could be used for assessing the bioaccumulation of chemicals in terrestrial organisms. © 2015 SETAC.

  11. Synthesis of the available information about the radioactive contamination of the Japanese terrestrial environment caused by the Fukushima Dai-ichi accident - September 27, 2011

    International Nuclear Information System (INIS)

    2011-01-01

    The French institute of radiation protection and nuclear safety (IRSN) collects and analyses regularly the published data concerning the contamination of the Japanese terrestrial environment caused by the Fukushima Dai-ichi power plant accident. This synthesis presents a status of the data recently obtained since the previous similar notes of April 12, May 25 and July 13. The note presents the detailed activity analysis of several surface soil samples, a mapping of 137 Cs, 134 Cs and 131 I activities with the spatial distribution of samplings in the 20, 30, 80 and 100 km areas around the damaged power plant, the contamination of agriculture food products and a focus on some vegetable products showing a significant contamination, like tea leaves, 'yuzu' fruits, figs and rice. Some other products, like meat, fungi and some milk products show cesium contamination levels above the Japanese standards while cesium and iodine are no longer detected in drinking water. (J.S.)

  12. Modelling of resuspension, seasonality and losses during food processing. First report of the VAMP terrestrial working group

    International Nuclear Information System (INIS)

    1992-05-01

    This is the first report of the Terrestrial Working Group of the Coordinated Research Programme. ''The validation of models for the transfer of radionuclides in terrestrial, urban and aquatic environments and the acquisition of data for that purpose''. The programme seeks to use information on the environmental behaviour of radionuclides available after the Chernobyl accident to test the reliability of assessment models. The models themselves are useful for assessing the radiological impact of all parts of the nuclear fuel cycle. This report contains reviews of three topics: resuspension of radioactive particles; removal of radionuclides during food processing; and seasonality of radioactive contamination of food. The three reviews have been indexed separately. Refs, figs and tabs

  13. Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review

    Directory of Open Access Journals (Sweden)

    Arezoo Rafiee Parhizgar

    2017-03-01

    Full Text Available Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ and amodiaquine (AQ, have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resistance to its other analogues have decreased their consumption in many geographical areas. On the other hand, AQ is an effective antimalarial drug which its usage has been restricted due to hepatic and hematological toxicities. The significance of the quinoline ring at quinoline-based antimalarial drugs has prompted research centers and pharmaceutical companies to focus on the design and synthesis of new analogues of these drugs, especially CQ and AQ analogues. Accordingly, various derivatives have been synthesized and evaluated in vitro and in vivo against the resistant strains of the malaria parasite to solve the problem of drug resistance. Also, the pharmacokinetic properties of these compounds have been evaluated to augment their efficacy and diminish their toxicity. Some of these analogues are currently in clinical and preclinical development. Consequently, the recent researches showed yet 4-aminoquinoline scaffold is active moiety in new compounds with antiplasmodial activity. Hence, the aim of this review article is to introduce of the novel synthetic analogues of CQ and AQ, which may constitute the next generation of antimalarial drugs with the 4-aminoquinoline scaffold.

  14. Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review.

    Science.gov (United States)

    Parhizgar, Arezoo Rafiee; Tahghighi, Azar

    2017-03-01

    Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resistance to its other analogues have decreased their consumption in many geographical areas. On the other hand, AQ is an effective antimalarial drug which its usage has been restricted due to hepatic and hematological toxicities. The significance of the quinoline ring at quinoline-based antimalarial drugs has prompted research centers and pharmaceutical companies to focus on the design and synthesis of new analogues of these drugs, especially CQ and AQ analogues. Accordingly, various derivatives have been synthesized and evaluated in vitro and in vivo against the resistant strains of the malaria parasite to solve the problem of drug resistance. Also, the pharmacokinetic properties of these compounds have been evaluated to augment their efficacy and diminish their toxicity. Some of these analogues are currently in clinical and preclinical development. Consequently, the recent researches showed yet 4-aminoquinoline scaffold is active moiety in new compounds with antiplasmodial activity. Hence, the aim of this review article is to introduce of the novel synthetic analogues of CQ and AQ, which may constitute the next generation of antimalarial drugs with the 4-aminoquinoline scaffold.

  15. Synthesis of tritium labelled phosphonate analogues of sphinganine-1-phosphate

    International Nuclear Information System (INIS)

    Schick, Andreas; Schwarzmann, Guenter; Kolter, Thomas; Sandhoff, Konrad

    1997-01-01

    Tritiated phosphonate analogues 9 and 10 are prepared as analogues of sphinganine-1-phosphate 4. The key step in this synthesis is the catalytic tritiation of the triple bond in reduction of the protected diethyl-3-(S)-tert.-butoxycarbonylamino -4-hydroxy-5-tridecinyl-1-phosphonate by means of sodium boro[ 3 H]hydride as tritium source. These compounds are synthesized to study their metabolic stability and to evaluate their biological properties. (author)

  16. Are terrestrial plumes from motionless plates analogues to Martian plumes feeding the giant shield volcanoes?

    Science.gov (United States)

    Meyzen, Christine; Massironi, Matteo; Pozzobon, Riccardo; Dal Zilio, Luca

    2014-05-01

    The near "one-plate" planet evolution of Mars has led to the edification of long-lasting giant shied volcanoes. Unlike the Earth, Mars would have been a transient convecting planet, where plate tectonic would have possibly acted only during the first hundreds of million years of its history. On Earth, where plate tectonic is active, most of them are regenerated and recycled through convection. However, the Nubian and Antarctic plates could be considered as poorly mobile surfaces of various thicknesses that are acting as conductive lids on top of Earth's deeper convective system. In these environments, volcanoes do not show any linear age progression at least for the last 30 Ma, but constitute the sites of persistent, focused long-term magmatic activity, rather than a chain of volcanoes as observed in fast-moving plate plume environments. Here, the near stationary absolute plate motion probably exerts a primary control on volcanic processes, and more specifically, on the melting ones. The residual depleted mantle, that is left behind by the melting processes, cannot be swept away from the melting locus. Over time, the thickening of this near-stationary depleted layer progressively forces the termination of melting to higher depths, reducing the melt production rate. Such a process gradually leads both to decreasing efficient melt extraction and increasing mantle lithospheric-melt interactions. The accumulation of this refractory material also causes long-term fluctuations of the volcanic activity, in generating long periods of quiescence. The presence of this residual mantle keel induces over time a lateral flow deflection, which translates into a shift of future melting sites around it. This process gives rise to the horseshoe-like shape of some volcanic islands on slow-moving plates (e.g. Cape Verde, Crozet). Finally, the pronounced topographic swells/bulges observed in this environments may also be supported both by large scale mantle upwelling and their residual

  17. Organic geochemical characterization of terrestrial source rocks of the Triassic Madygen formation (Southern Tien Shan, Kyrgyzstan)

    Energy Technology Data Exchange (ETDEWEB)

    Berner, U.; Scheeder, G.; Kus, J. [Section Geochemistry of Petroleum and Coal, BGR, Hannover (Germany); Voigt, S.; Schneider, J.W. [Geological Inst., TU Bergakademic Freiberg (Germany)

    2009-09-15

    Along the northern foothills of the Turkestan-Alai Range (SW Kyrgyzstan), a 1000 to 1500m thick succession of Mesozoic deposits is exposed recording regional changes of the paleo-landscape during Triassic to Cretaceous times. Detailed litho- and biofacies analyses, conducted by the TU Bergakademie Freiberg since 2006, provided for the first time a nearly complete columnar section of the continental Triassic Madygen Formation of Kyrgyzstan. Organic petrographical and organic geochemical methods (including RockEval pyrolyses, and biomarker analyses) have been applied to a suite of terrestrial sedimentary rocks of Triassic age with the intention to identify the depositional environment. Our investigations suggest that the potential source rocks of the terrestrial pluvial Madygen Formation might generate predominantly gaseous hydrocarbons at higher maturities. (orig.)

  18. The fragmentation of Pangaea and Mesozoic terrestrial vertebrate biodiversity.

    Science.gov (United States)

    Vavrek, Matthew J

    2016-09-01

    During the Mesozoic (242-66 million years ago), terrestrial regions underwent a massive shift in their size, position and connectivity. At the beginning of the era, the land masses were joined into a single supercontinent called Pangaea. However, by the end of the Mesozoic, terrestrial regions had become highly fragmented, both owing to the drifting apart of the continental plates and the extremely high sea levels that flooded and divided many regions. How terrestrial biodiversity was affected by this fragmentation and large-scale flooding of the Earth's landmasses is uncertain. Based on a model using the species-area relationship (SAR), terrestrial vertebrate biodiversity would be expected to nearly double through the Mesozoic owing to continental fragmentation, despite a decrease of 24% in total terrestrial area. Previous studies of Mesozoic vertebrates have generally found increases in terrestrial diversity towards the end of the era, although these increases are often attributed to intrinsic or climatic factors. Instead, continental fragmentation over this time may largely explain any observed increase in terrestrial biodiversity. This study demonstrates the importance that non-intrinsic effects can have on the taxonomic success of a group, and the importance of geography to understanding past biodiversity. © 2016 The Author(s).

  19. A silyl andrographolide analogue suppresses Wnt/β-catenin signaling pathway in colon cancer.

    Science.gov (United States)

    Reabroi, Somrudee; Chairoungdua, Arthit; Saeeng, Rungnapha; Kasemsuk, Teerapich; Saengsawang, Witchuda; Zhu, Weiming; Piyachaturawat, Pawinee

    2018-05-01

    Hyperactivation of Wnt/β-catenin signaling implicated in oncogenesis of colorectal cancer (CRC) is a potential molecular target for chemotherapy. An andrographolide analogue, 3A.1 (19-tert-butyldiphenylsilyl-8, 17-epoxy andrographolide) has previously been reported to be potently cytotoxic toward cancer cells by unknown molecular mechanisms. The present study explored the anti-cancer activity of analogue 3A.1 on Wnt/β-catenin signaling in colon cancer cells (HT29 cells) which were more sensitive to the others (HCT116 and SW480 cells). Analogue 3A.1 inhibited viability of HT29 cells with IC 50 value of 11.1 ± 1.4 μM at 24 h, which was more potent than that of the parent andrographolide. Analogue 3A.1 also suppressed the proliferation of HT29 cells and induced cell apoptosis in a dose-dependent manner. Its apoptotic activity was accompanied with increased expressions of proteins related to DNA damages; PARP-1 and γ-H2AX. In addition, analogue 3A.1 significantly inhibited T-cell factor and lymphoid enhancer factor (TCF/LEF) promoter activity of Wnt/β-catenin signaling. Accordingly, the expressions of Wnt target genes and β-catenin protein were suppressed. Moreover, analogue 3A.1 increased the activity of GSK-3β kinase, which is a negative regulator responsible for degradation of intracellular β-catenin. This mode of action was further supported by the absence of the effects after treatment with a GSK-3β inhibitor, and over-expression of a mutant β-catenin (S33Y). Our findings reveal, for the first time, an insight into the molecular mechanism of the anti-cancer activity of analogue 3A.1 through the inhibition of Wnt/β-catenin/GSK-3β pathway and provide a therapeutic potential of the andrographolide analogue 3A.1 in CRC treatment. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  20. Hybrid Terrestrial-Satellite DVB/IP Infrastructure in Overlay Constellations for Triple-Play Services Access in Rural Areas

    Directory of Open Access Journals (Sweden)

    E. Pallis

    2010-01-01

    Full Text Available This paper discusses the convergence of digital broadcasting and Internet technologies, by elaborating on the design, implementation, and performance evaluation of a hybrid terrestrial/satellite networking infrastructure, enabling triple-play services access in rural areas. At local/district level, the paper proposes the exploitation of DVB-T platforms in regenerative configurations for creating terrestrial DVB/IP backhaul between the core backbone (in urban areas and a number of intermediate communication nodes distributed within the DVB-T broadcasting footprint (in rural areas. In this way, triple play services that are available at the core backbone, are transferred via the regenerative DVB-T/IP backhaul to the entire district and can be accessed by rural users via the corresponding intermediate node. On the other hand, at regional/national level, the paper proposes the exploitation of a satellite interactive digital video broadcasting platform (DVB S2/RCS as an overlay network that interconnects the regenerative DVB-T/IP platforms, as well as individual users, and services providers, to each other. Performance of the proposed hybrid terrestrial/satellite networking environment is validated through experimental tests that were conducted under real transmission/reception conditions (for the terrestrial segment and via simulation experiments (for the satellite segment at a prototype network infrastructure.

  1. ACCURACY ASSESSMENT OF MOBILE MAPPING POINT CLOUDS USING THE EXISTING ENVIRONMENT AS TERRESTRIAL REFERENCE

    Directory of Open Access Journals (Sweden)

    S. Hofmann

    2016-06-01

    Full Text Available Mobile mapping data is widely used in various applications, what makes it especially important for data users to get a statistically verified quality statement on the geometric accuracy of the acquired point clouds or its processed products. The accuracy of point clouds can be divided into an absolute and a relative quality, where the absolute quality describes the position of the point cloud in a world coordinate system such as WGS84 or UTM, whereas the relative accuracy describes the accuracy within the point cloud itself. Furthermore, the quality of processed products such as segmented features depends on the global accuracy of the point cloud but mainly on the quality of the processing steps. Several data sources with different characteristics and quality can be thought of as potential reference data, such as cadastral maps, orthophoto, artificial control objects or terrestrial surveys using a total station. In this work a test field in a selected residential area was acquired as reference data in a terrestrial survey using a total station. In order to reach high accuracy the stationing of the total station was based on a newly made geodetic network with a local accuracy of less than 3 mm. The global position of the network was determined using a long time GNSS survey reaching an accuracy of 8 mm. Based on this geodetic network a 3D test field with facades and street profiles was measured with a total station, each point with a two-dimensional position and altitude. In addition, the surface of poles of street lights, traffic signs and trees was acquired using the scanning mode of the total station. Comparing this reference data to the acquired mobile mapping point clouds of several measurement campaigns a detailed quality statement on the accuracy of the point cloud data is made. Additionally, the advantages and disadvantages of the described reference data source concerning availability, cost, accuracy and applicability are discussed.

  2. Accelerator mass analyses of meteorites - carbon-14 terrestrial ages

    International Nuclear Information System (INIS)

    Miura, Y.; Rucklidge, J.; Beukens, R.; Fireman, E.

    1988-01-01

    Carbon-14 terrestrial ages of ten Antarctic meteorites have been measured by the IsoTrace accelerator mass spectrometry (AMS). The 14 C terrestrial age of 1 gram sample was determined from 14 C concentrations collected at melt and re-melt temperatures, compared with the 14 C concentration of the known Bruderheim chondrite. Yamato-790448 (LL3) chondrite was found to be the oldest terrestrial age of 3x10 4 years in the nine Yamato chondrites, whereas Yamato-791630 (L4) chondrite is considered to be the youngest chondrites less than thousand years. Allan Hills chondrite of ALH-77231 (L6) shows older terrestrial age than the nine Yamato chondrites. New accelerator data of the terrestrial age show higher accuracy with smaller sample than the previous counting method. (author)

  3. Structure of the terrestrial planets

    International Nuclear Information System (INIS)

    Lyttleton, R.A.

    1977-01-01

    Recent reviews (cf. Runcorn, 1968; or Cook, 1972, 1975) on the structure of the planets omit reference to the phase-change hypothesis for the nature of the terrestrial core, despite that numerous prior predictions of the theory based on this hypothesis have subsequently been borne out as correct. These reviews also ignore the existence of theoretical calculations of the internal structure of Venus which can be computed with high accuracy by use of the terrestrial seismic data. Several examples of numerous mistakes committed in these reviews are pointed out. (Auth.)

  4. Global screening for Critical Habitat in the terrestrial realm.

    Science.gov (United States)

    Brauneder, Kerstin M; Montes, Chloe; Blyth, Simon; Bennun, Leon; Butchart, Stuart H M; Hoffmann, Michael; Burgess, Neil D; Cuttelod, Annabelle; Jones, Matt I; Kapos, Val; Pilgrim, John; Tolley, Melissa J; Underwood, Emma C; Weatherdon, Lauren V; Brooks, Sharon E

    2018-01-01

    Critical Habitat has become an increasingly important concept used by the finance sector and businesses to identify areas of high biodiversity value. The International Finance Corporation (IFC) defines Critical Habitat in their highly influential Performance Standard 6 (PS6), requiring projects in Critical Habitat to achieve a net gain of biodiversity. Here we present a global screening layer of Critical Habitat in the terrestrial realm, derived from global spatial datasets covering the distributions of 12 biodiversity features aligned with guidance provided by the IFC. Each biodiversity feature is categorised as 'likely' or 'potential' Critical Habitat based on: 1. Alignment between the biodiversity feature and the IFC Critical Habitat definition; and 2. Suitability of the spatial resolution for indicating a feature's presence on the ground. Following the initial screening process, Critical Habitat must then be assessed in-situ by a qualified assessor. This analysis indicates that a total of 10% and 5% of the global terrestrial environment can be considered as likely and potential Critical Habitat, respectively, while the remaining 85% did not overlap with any of the biodiversity features assessed and was classified as 'unknown'. Likely Critical Habitat was determined principally by the occurrence of Key Biodiversity Areas and Protected Areas. Potential Critical Habitat was predominantly characterised by data representing highly threatened and unique ecosystems such as ever-wet tropical forests and tropical dry forests. The areas we identified as likely or potential Critical Habitat are based on the best available global-scale data for the terrestrial realm that is aligned with IFC's Critical Habitat definition. Our results can help businesses screen potential development sites at the early project stage based on a range of biodiversity features. However, the study also demonstrates several important data gaps and highlights the need to incorporate new and

  5. Synthesis and formulation studies of griseofulvin analogues with improved solubility and metabolic stability

    DEFF Research Database (Denmark)

    Petersen, Asger Bjørn; Andersen, Nikolaj Sten; Konotop, Gleb

    2017-01-01

    Griseofulvin (1) is an important antifungal agent that has recently received attention due to its antiproliferative activity in mammalian cancer cells. Comprehensive SAR studies have led to the identification of 2'-benzyloxy griseofulvin 2, a more potent analogue with low micromolar anticancer...... potency in vitro. Analogue 2 was also shown to retard tumor growth through inhibition of centrosomal clustering in murine xenograft models of colon cancer and multiple myeloma. However, similar to griseofulvin, compound 2 exhibited poor metabolic stability and aqueous solubility. In order to improve...... studies. The 2'-benzylamine analogue 10 proved to be the most promising compound with low μM in vitro anticancer potency, a 200-fold increase in PBS solubility over compound 2, and with improved metabolic stability. Furthermore, this analogue proved compatible with formulations suitable for both oral...

  6. Natural analogue synthesis report, TDR-NBS-GS-000027 REV00 ICN02

    International Nuclear Information System (INIS)

    Simmons, A.; Nieder-Westermann, G.; Stuckless, J.; Dobson, P.; Unger, A.J.A.; Kwicklis, E.; Lichtner, P.; Carey, B.; Wolde, G.; Murrel, M.; Kneafsey, T.J.; Meijer, A.; Faybishenko, B.

    2002-01-01

    The purpose of this report is to present analogue studies and literature reviews designed to provide qualitative and quantitative information to test and provide added confidence in process models abstracted for performance assessment (PA) and model predictions pertinent to PA. This report provides updates to studies presented in the Yucca Mountain Site Description (CRWMS M and O 2000 [151945], Section 13) and new examples gleaned from the literature, along with results of quantitative studies conducted specifically for the Yucca Mountain Site Characterization Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate additional understanding of processes expected to occur during postclosure at a potential Yucca Mountain repository. The report focuses on key processes by providing observations and analyses of natural and anthropogenic (human-induced) systems to improve understanding and confidence in the operation of these processes under conditions similar to those that could occur in a nuclear waste repository. The process models include those that represent both engineered and natural barrier processes. A second purpose of this report is to document the various applications of natural analogues to geologic repository programs, focusing primarily on the way analogues have been used by the YMP. This report is limited to providing support for PA in a confirmatory manner and to providing corroborative inputs for process modeling activities. Section 1.7 discusses additional limitations of this report. Key topics for this report are analogues to emplacement drift degradation, waste form degradation, waste package degradation, degradation of other materials proposed for the engineered barrier, seepage into drifts, radionuclide flow and transport in the unsaturated zone (UZ), analogues to coupled thermal-hydrologic-mechanical-chemical processes, saturated zone (SZ) transport, impact of radionuclide

  7. Natural analogue synthesis report, TDR-NBS-GS-000027 rev00 icn02

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, A.; Nieder-Westermann, G.; Stuckless, J.; Dobson, P.; Unger, A.J.A.; Kwicklis, E.; Lichtner, P.; Carey, B.; Wolde, G.; Murrel,M.; Kneafsey, T.J.; Meijer, A.; Faybishenko, B.

    2002-04-01

    The purpose of this report is to present analogue studies and literature reviews designed to provide qualitative and quantitative information to test and provide added confidence in process models abstracted for performance assessment (PA) and model predictions pertinent to PA. This report provides updates to studies presented in the Yucca Mountain Site Description (CRWMS M&O 2000 [151945], Section 13) and new examples gleaned from the literature, along with results of quantitative studies conducted specifically for the Yucca Mountain Site Characterization Project (YMP). The intent of the natural analogue studies was to collect corroborative evidence from analogues to demonstrate additional understanding of processes expected to occur during postclosure at a potential Yucca Mountain repository. The report focuses on key processes by providing observations and analyses of natural and anthropogenic (human-induced) systems to improve understanding and confidence in the operation of these processes under conditions similar to those that could occur in a nuclear waste repository. The process models include those that represent both engineered and natural barrier processes. A second purpose of this report is to document the various applications of natural analogues to geologic repository programs, focusing primarily on the way analogues have been used by the YMP. This report is limited to providing support for PA in a confirmatory manner and to providing corroborative inputs for process modeling activities. Section 1.7 discusses additional limitations of this report. Key topics for this report are analogues to emplacement drift degradation, waste form degradation, waste package degradation, degradation of other materials proposed for the engineered barrier, seepage into drifts, radionuclide flow and transport in the unsaturated zone (UZ), analogues to coupled thermal-hydrologic-mechanical-chemical processes, saturated zone (SZ) transport, impact of radionuclide release

  8. Space plasma observations - observations of solar-terrestrial environment. Space Weather Forecast

    International Nuclear Information System (INIS)

    Sagawa, Eiichi; Akioka, Maki

    1996-01-01

    The space environment becomes more important than ever before because of the expansion in the utilization of near-earth space and the increase in the vulnerability of large scale systems on the ground such as electrical power grids. The concept of the Space Weather Forecast program emerged from the accumulation of understanding on basic physical processes and from our activities as one of the regional warning centers of the international network of space environment services. (author)

  9. The importance of analogue zeitgebers to reduce digital addictive tendencies in the 21st century

    Directory of Open Access Journals (Sweden)

    Christian Montag

    2015-12-01

    Full Text Available Analogue zeitgebers such as wristwatches and alarm clocks are essential for structuring everyday life. Since the dawn of the digital revolution – particularly since the advent of the smartphone – mobile phones have increasingly replaced analogue zeitgebers as a means of telling time. This functionality may prove problematic, in that it may contribute to the overuse of digital media (e.g. when checking the time turns into extended use of other smartphone utilities, including Internet-based applications. Of N = 3084 participants, 45% reported wearing a wristwatch and 67% used an analogue alarm clock. We observed that participants who reported using analogue zeitgebers used their mobile-/smartphone significantly less. Use of analogue zeitgebers may prove a practical tool for therapeutic and preventative interventions for problematic Internet use in an increasingly digital age.

  10. Terrestrial magnetosphere

    International Nuclear Information System (INIS)

    Pande, D.C.; Agarwal, D.C.

    1982-01-01

    This paper presents a review about terrestrial magnetosphere. During the last few years considerable investigation have been carried out about the properties of Solar Wind and its interaction with planetary magnetic fields. It is therefore of high importance to accumulate all the investigations in a comprehensive form. The paper reviews the property of earth's magnetosphere, magnetosheath, magneto pause, polar cusps, bow shook and plasma sheath. (author)

  11. PENGEMBANGAN BERAS ANALOG DENGAN MEMANFAATKAN JAGUNG PUTIH [Development of White Corn-Based Rice Analogues

    Directory of Open Access Journals (Sweden)

    Santi Noviasari*

    2013-12-01

    Full Text Available White corn can be utilized as a source of non-rice carbohydrate in the manufacture of rice analogues. The rice analogues with rice-like characteristics were produced by an extrusion technique. The aim of this research was to develop rice analogues from white corn and to evaluate their physicochemical and sensory properties. The study was conducted in several stages, i.e. preparation, formulation, and physicochemical and sensory properties evaluation. The physicochemical properties of rice analogues evaluated included proximate nutritional composition, dietary fiber concentration, cooking time, water loss rate, color, and whiteness percentage, while their sensory preferences were evaluated using hedonic scale test. The rice analogues made of Pulut Harapan and Lokal Purbalingga corns (4.34:65.66% added with 30% sago starch, was found to be the most preferred. The moisture, ash, protein, fat, carbohydrate, and dietary fiber composition of this rice analog was 9.32, 0.38, 6.86, 1.22, 91.54, and 5.35%, respectively.

  12. Synthesis and preliminary pharmacological evaluation of asymmetric chloroquine analogues.

    Science.gov (United States)

    Witiak, D T; Grattan, D A; Heaslip, R J; Rahwan, R G

    1981-06-01

    Asymmetric chloroquine analogues (1-4) were prepared of known absolute configuration in order to assess stereochemical influences on selected biological activities. Since chloroquine has been shown to possess spasmolytic properties, analogues 1-4 were tested for similar pharmacological effects on smooth-muscle contraction. The (S)- and (R)-chlorochloroquine enantiomers (1 and 2, respectively) were more potent antispasmodics than the less lipophilic (S)- and (R)-hydroxychloroquines (3 and 4, respectively) when tested against KCl- or acetylcholine-induced contractions of the isolated mouse ileum. A membrane stabilizing mechanism of action for the chloroquine analogues is proposed since neither cellular toxicity nor calcium antagonism plays a role in the spasmolytic action of these compounds. Although compounds 1-4 also inhibited PGF2 alpha-induced contractions of the ileum, 1 was significantly more potent than 2; the latter in turn was equipotent to 3 and 4. It is tentatively proposed that 1 may possess stereoselective affinity for the PGF2 alpha receptor in the ileum. This observation may be further exploited to obtain more selective profiles of biological activity through molecular manipulation.

  13. Do film soundtracks contain nonlinear analogues to influence emotion?

    Science.gov (United States)

    Blumstein, Daniel T; Davitian, Richard; Kaye, Peter D

    2010-12-23

    A variety of vertebrates produce nonlinear vocalizations when they are under duress. By their very nature, vocalizations containing nonlinearities may sound harsh and are somewhat unpredictable; observations that are consistent with them being particularly evocative to those hearing them. We tested the hypothesis that humans capitalize on this seemingly widespread vertebrate response by creating nonlinear analogues in film soundtracks to evoke particular emotions. We used lists of highly regarded films to generate a set of highly ranked action/adventure, dramatic, horror and war films. We then scored the presence of a variety of nonlinear analogues in these film soundtracks. Dramatic films suppressed noise of all types, contained more abrupt frequency transitions and musical sidebands, and fewer noisy screams than expected. Horror films suppressed abrupt frequency transitions and musical sidebands, but had more non-musical sidebands, and noisy screams than expected. Adventure films had more male screams than expected. Together, our results suggest that film-makers manipulate sounds to create nonlinear analogues in order to manipulate our emotional responses.

  14. Introduced Terrestrial Species (Future)

    Data.gov (United States)

    U.S. Environmental Protection Agency — These data represent predicted future potential distributions of terrestrial plants, animals, and pathogens non-native to the Middle-Atlantic region. These data are...

  15. Do GnRH analogues directly affect human endometrial epithelial cell gene expression?

    KAUST Repository

    Zhang, Xiaomei; Bocca, Silvina Maria; Franchi, Anahí ; Anderson, Sandra; Kaur, Mandeep; Bajic, Vladimir B.; Oehninger, Sergio Carlos

    2010-01-01

    were: (i) to study the modulatory effect of GnRH analogues by RT-PCR [in the absence and presence of E2 and P4, and cyclic adenosine monophos-phate (cAMP)] on mRNA expression of genes modulated during the window of implantation in GnRH analogues

  16. Marine invasions by non-sea snakes, with thoughts on terrestrial-aquatic-marine transitions.

    Science.gov (United States)

    Murphy, John C

    2012-08-01

    Few species of snakes show extensive adaptations to aquatic environments and even fewer exploit the oceans. A survey of morphology, lifestyles, and habitats of 2552 alethenophidian snakes revealed 362 (14%) that use aquatic environments, are semi-aquatic, or aquatic; about 70 (2.7%) of these are sea snakes (Hydrophiinae and Laticaudinae). The ancient and aquatic family Acrochordidae contains three extant species, all of which have populations inhabiting brackish or marine environments, as well as freshwater. The Homalopsidae have the most ecologically diverse representatives in coastal habitats. Other families containing species exploiting saline waters with populations in freshwater environments include: the Dipsadidae of the western hemisphere, the cosmopolitan Natricidae, the African Grayinae, and probably a few Colubridae. Species with aquatic and semi-aquatic lifestyles are compared with more terrestrial (fossorial, cryptozoic, and arboreal) species for morphological traits and life histories that are convergent with those found in sea snakes; this may provide clues to the evolution of marine snakes and increase our understanding of snake diversity.

  17. TERRESTRIAL, HABITABLE-ZONE EXOPLANET FREQUENCY FROM KEPLER

    International Nuclear Information System (INIS)

    Traub, Wesley A.

    2012-01-01

    Data from Kepler's first 136 days of operation are analyzed to determine the distribution of exoplanets with respect to radius, period, and host-star spectral type. The analysis is extrapolated to estimate the percentage of terrestrial, habitable-zone (HZ) exoplanets. The Kepler census is assumed to be complete for bright stars (magnitude 0.5 Earth radius and periods β–1 , with β ≅ 0.71 ± 0.08; and an extrapolation to longer periods gives the frequency of terrestrial planets in the HZs of FGK stars as η ⊕ ≅ (34 ± 14)%. Thus about one-third of FGK stars are predicted to have at least one terrestrial, HZ planet.

  18. Convergent evidence for widespread rock nitrogen sources in Earth’s surface environment

    Science.gov (United States)

    Houlton, B. Z.; Morford, S. L.; Dahlgren, R. A.

    2018-04-01

    Nitrogen availability is a pivotal control on terrestrial carbon sequestration and global climate change. Historical and contemporary views assume that nitrogen enters Earth’s land-surface ecosystems from the atmosphere. Here we demonstrate that bedrock is a nitrogen source that rivals atmospheric nitrogen inputs across major sectors of the global terrestrial environment. Evidence drawn from the planet’s nitrogen balance, geochemical proxies, and our spatial weathering model reveal that ~19 to 31 teragrams of nitrogen are mobilized from near-surface rocks annually. About 11 to 18 teragrams of this nitrogen are chemically weathered in situ, thereby increasing the unmanaged (preindustrial) terrestrial nitrogen balance from 8 to 26%. These findings provide a global perspective to reconcile Earth’s nitrogen budget, with implications for nutrient-driven controls over the terrestrial carbon sink.

  19. Spatial vision in Bombus terrestris

    Directory of Open Access Journals (Sweden)

    Aravin eChakravarthi

    2016-02-01

    Full Text Available Bombus terrestris is one of the most commonly used insect models to investigate visually guided behavior and spatial vision in particular. Two fundamental measures of spatial vision are spatial resolution and contrast sensitivity. In this study, we report the threshold of spatial resolution in B. terrestris and characterize the contrast sensitivity function of the bumblebee visual system for a dual choice discrimination task. We trained bumblebees in a Y-maze experimental set-up to associate a vertical sinusoidal grating with a sucrose reward, and a horizontal grating with absence of a reward. Using a logistic psychometric function, we estimated a resolution threshold of 0.21 cycles deg-1 of visual angle. This resolution is in the same range but slightly lower than that found in honeybees (Apis mellifera and A. cerana and another bumblebee species (B. impatiens. We also found that the contrast sensitivity of B. terrestris was 1.57 for the spatial frequency 0.09 cycles deg-1 and 1.26. for 0.18 cycles deg-1.

  20. Field Comparisons of Three Biomarker Detection Methods in Icelandic Mars Analogue Environments

    Science.gov (United States)

    Gentry, D.; Amador, E. S.; Cable, M. L.; Chaudry, N.; Cullen, T.; Jacobsen, M.; Murusekan, G.; Schwieterman, E.; Stevens, A.; Stockton, A.; Yin, C.; Cullen, D.; Geppert, W.

    2014-12-01

    The ability to estimate the spatial and temporal distributions of biomarkers has been identified as a key need for planning life detection strategies. In a typical planetary exploration scenario, sampling site selection will be informed only by remote sensing data; however, if a difference of a few tens of meters, or centimeters, makes a significant difference in the results, science objectives may not be met. We conducted an analogue planetary expedition to test the correlation of three common biomarker detection methods -- cell counts through fluorescence microscopy, ATP quantification, and quantitative PCR with universal primer sets (bacteria, archaea, and fungi) -- and their spatial scale representativeness. Sampling sites in recent Icelandic lava fields (Fimmvörđuháls and Eldfell) spanned four nested spatial scales: 1 m, 10 m, 100 m, and > 1 km. Each site was homogeneous at typical 'remote sampling' resolution (overall temperature, apparent moisture content, and regolith grain size). No correlation between cell counts and either ATP or qPCR data was significant at any distance scale; ATP quantification and the archaeal and fungal qPCR data showed a marginal negative correlation at the 1 m level. Visible cell count data was statistically site-dependent for sites 10 m and 100 m apart, but not for sites > 1 km apart, whereas ATP results and qPCR data showed site dependence at all four scales. Distance had no significant effect on variability in cell counts and qPCR data, but was positively correlated with ATP variability. These results highlight the difficulty of choosing a 'good' biomarker: not only may different methods yield conflicting results, but they may also be differentially representative of the overall area. We intend to expand on this work with a follow-up campaign using comprehensive assays of physicochemical site properties to better distinguish between effects of environmental variability and intrinsic biomarker variability.

  1. q-bosons and the q-analogue quantized field

    International Nuclear Information System (INIS)

    Nelson, C.A.

    1994-01-01

    The q-analogue coherent states |z > q are used to identify physical signatures for the presence of a q-analogue quantized radiation field in the | > q classical limit where |z| is large. In this quantum-optics-like limit, the fractional uncertainties of most physical quantities (momentum, position, amplitude, phase) which characterize the quantum field are O(1). They only vanish as O(1/|z|) when q = 1. However, for the number operator, N, and the N-Hamiltonian for a free q-boson gas, H N = ℎω(N + 1/2), the fractional uncertainties do still approach zero. A signature for q-boson counting statistics is that (ΔN) 2 / → 0 as |z| → ∞. Except for its O(1) fractional uncertainty, the q-generalization of the Hermitian phase operator of Pegg and Barnett, φ q , still exhibits normal classical behavior. The standard number-phase uncertainty-relation, ΔN Δφ q = 1/2, and the approximate commutation relation, [N,φ q ] = i, still hold for the single-mode q-analogue quantized field. So, N and φ q are almost canonically conjugate operators in the |z > q classical limit. The |z > q CS's minimize this uncertainty relation for moderate |z| 2

  2. Can plastic bag derived-microplastics act as vectors for metal exposure in terrestrial invertebrates?

    Science.gov (United States)

    E Hodson, Mark; Duffus-Hodson, Calum A.; Prendergast-Miller, Miranda; Thorpe, Karen

    2017-04-01

    Microplastics are widely reported contaminants in marine and freshwater ecosystems and studies have shown that they can be ingested by aquatic organisms and lead to potential negative effects on health. The effects can arise from the physical effects of the plastics (e.g. food displacement and blockages of the digestive tract) and from their potential to adsorb contaminants, primarily organic compounds, resulting in an increased exposure of the organism to toxic contaminants. Studies are beginning to emerge that also show a high abundance of microplastics in the terrestrial environment but there remains a lack of data on the impacts of these terrestrial microplastics or their interaction with other terrestrial pollutants. We conducted Zn adsorption experiments using HDPE microplastics, derived from plastic bags. Zinc adsorption to microplastics was similar to that observed in soils, but in the presence of both soil and microplastics, preferential adsorption onto the soil was observed. In desorption experiments, desorption of Zn from microplastics and soils was minimal (soils. In earthworm exposure experiments Lumbricus terrestris earthworms cultivated in soils containing 0.35% by mass of Zn-bearing plastic (236 - 4505 mg kg-1) ingested the microplastics with no evidence for either preferential feeding or avoidance. There was no evidence for an accumulation of the microplastics in the earthworm gut or for signs of toxicity. Our experiments demonstrate that earthworms will ingest microplastics and that microplastics can adsorb metals and act as vectors for metal exposure in soil invertebrates. However, for Zn, the risk associated with this exposure appears to be minimal.

  3. Higher-dimensional analogues of Donaldson-Witten theory

    International Nuclear Information System (INIS)

    Acharya, B.S.; Spence, B.

    1997-01-01

    We present a Donaldson-Witten-type field theory in eight dimensions on manifolds with Spin(7) holonomy. We prove that the stress tensor is BRST exact for metric variations preserving the holonomy and we give the invariants for this class of variations. In six and seven dimensions we propose similar theories on Calabi-Yau threefolds and manifolds of G 2 holonomy, respectively. We point out that these theories arise by considering supersymmetric Yang-Mills theory defined on such manifolds. The theories are invariant under metric variations preserving the holonomy structure without the need for twisting. This statement is a higher-dimensional analogue of the fact that Donaldson-Witten field theory on hyper-Kaehler 4-manifolds is topological without twisting. Higher-dimensional analogues of Floer cohomology are briefly outlined. All of these theories arise naturally within the context of string theory. (orig.)

  4. Making Connections in Math: Activating a Prior Knowledge Analogue Matters for Learning

    Science.gov (United States)

    Sidney, Pooja G.; Alibali, Martha W.

    2015-01-01

    This study investigated analogical transfer of conceptual structure from a prior-knowledge domain to support learning in a new domain of mathematics: division by fractions. Before a procedural lesson on division by fractions, fifth and sixth graders practiced with a surface analogue (other operations on fractions) or a structural analogue (whole…

  5. The anti-inflammatory activity of dillapiole and some semisynthetic analogues.

    Science.gov (United States)

    Parise-Filho, Roberto; Pastrello, Michelli; Pereira Camerlingo, Carla Emygdio; Silva, Gisele Juni; Agostinho, Leonardo Aguiar; de Souza, Thaís; Motter Magri, Fátima Maria; Ribeiro, Roberto Rodrigues; Brandt, Carlos Alberto; Polli, Michelle Carneiro

    2011-11-01

    Piper aduncum L. (Piperaceae) produces an essential oil (dillapiole) with great exploitative potential and it has proven effects against traditional cultures of phytopathogens, such as fungi, bacteria and mollusks, as well as analgesic action with low levels of toxicity. This study investigated the in vivo anti-inflammatory activity of dillapiole. Furthermore, in order to elucidate its structure-anti-inflammatory activity relationship (SAR), semisynthetic analogues were proposed by using the molecular simplification strategy. Dillapiole and safrole were isolated and purified using column chromatography. The semisynthetic analogues were obtained by using simple organic reactions, such as catalytic reduction and isomerization. All the analogues were purified by column chromatography and characterized by (1)H and (13)C NMR. The anti-inflammatory activities of dillapiole and its analogues were studied in carrageenan-induced rat paw edema model. Dillapiole and di-hydrodillapiole significantly (p<0.05) inhibited rat paw edema. All the other substances tested, including safrole, were less powerful inhibitors with activities inferior to that of indomethacin. These findings showed that dillapiole and di-hydrodillapiole have moderate anti-phlogistic properties, indicating that they can be used as prototypes for newer anti-inflammatory compounds. Structure-activity relationship studies revealed that the benzodioxole ring is important for biological activity as well as the alkyl groups in the side chain and the methoxy groups in the aromatic ring.

  6. Design of ultra-stable insulin analogues for the developing world

    Directory of Open Access Journals (Sweden)

    Michael A Weiss

    2013-01-01

    Full Text Available The engineering of insulin analogues illustrates the application of structure-based protein design to clinical medicine. Such design has traditionally been based on structures of wild-type insulin hexamers in an effort to optimize the pharmacokinetic (PK and pharmacodynamic properties of the hormone. Rapid-acting insulin analogues (in chronological order of their clinical introduction, Humalog ® [Eli Lilly & Co.], Novolog ® [Novo-Nordisk], and Apidra ® [Sanofi-Aventis] exploit the targeted destabilization of subunit interfaces to facilitate capillary absorption. Conversely, long-acting insulin analogues exploit the stability of the insulin hexamer and its higher-order self-assembly within the subcutaneous depot to enhance basal glycemic control. Current products either operate through isoelectric precipitation (insulin glargine, the active component of Lantus ® ; Sanofi-Aventis or employ an albumin-binding acyl tether (insulin detemir, the active component of Levemir ® ; Novo-Nordisk. Such molecular engineering has often encountered a trade-off between PK goals and product stability. Given the global dimensions of the diabetes pandemic and complexity of an associated cold chain of insulin distribution, we envisage that concurrent engineering of ultra-stable protein analogue formulations would benefit the developing world, especially for patients exposed to high temperatures with inconsistent access to refrigeration. We review the principal mechanisms of insulin degradation above room temperature and novel molecular approaches toward the design of ultra-stable rapid-acting and basal formulations.

  7. The Spectrum Landscape: Prospects for Terrestrial Radio Astronomy

    Science.gov (United States)

    Liszt, Harvey Steven

    2018-01-01

    means, by which radio astronomy can take an active role in shaping its terrestrial environment.

  8. Recombinant DNA derived monomeric insulin analogue: comparison with soluble human insulin in normal subjects.

    Science.gov (United States)

    Vora, J P; Owens, D R; Dolben, J; Atiea, J A; Dean, J D; Kang, S; Burch, A; Brange, J

    1988-11-12

    To compare the rate of absorption from subcutaneous tissue and the resulting hypoglycaemic effect of iodine-125 labelled soluble human insulin and a monomeric insulin analogue derived by recombinant DNA technology. Single blind randomised comparison of equimolar doses of 125I labelled soluble human insulin and insulin analogue. Study in normal people at a diabetes research unit and a university department of medical physics. Seven healthy male volunteers aged 20-39 not receiving any other drugs. After an overnight fast and a basal period of one hour two doses (0.05 and 0.1 U/kg) of 125I labelled soluble human insulin and insulin analogue were injected subcutaneously into the anterior abdominal wall on four separate days. To find a fast acting insulin for meal related requirements in insulin dependent diabetics. MEASUREMENTS and main results--Residual radioactivity at the injection site was measured continuously for the first two hours after injection of the 125I labelled preparations and thereafter for five minutes simultaneously with blood sampling. Frequent venous blood samples were obtained over six hours for determination of plasma immunoreactive insulin, insulin analogue, glucose, and glucagon values. Time to 50% of initial radioactivity at the injection site for the insulin analogue compared with soluble insulin was 61 v 135 minutes (p less than 0.05) with 0.05 U/kg and 67 v 145 minutes (p less than 0.001) with 0.1 U/kg. Concentrations in plasma increased faster after the insulin analogue compared with soluble insulin, resulting in higher plasma concentrations between 10 and 150 minutes (0.001 less than p less than 0.05) after 0.05 U/kg and between 40 and 360 minutes (0.001 less than p less than 0.05) after 0.1 U/kg. The hypoglycaemic response to insulin analogue was a plasma glucose nadir at 60 minutes with both doses compared with 90 and 120 minutes with soluble insulin at 0.5 and 0.1 U/kg respectively. The response of glucagon substantiated the earlier and

  9. Genie in a blotter: A comparative study of LSD and LSD analogues' effects and user profile.

    Science.gov (United States)

    Coney, Leigh D; Maier, Larissa J; Ferris, Jason A; Winstock, Adam R; Barratt, Monica J

    2017-05-01

    This study aimed to describe self-reported patterns of use and effects of lysergic acid diethylamide (LSD) analogues (AL-LAD, 1P-LSD, and ETH-LAD) and the characteristics of those who use them. An anonymous self-selected online survey of people who use drugs (Global Drug Survey 2016; N = 96,894), which measured perceived drug effects of LSD and its analogues. Most LSD analogue users (91%) had also tried LSD. The proportion of U.K. and U.S. respondents reporting LSD analogue use in the last 12 months was higher than for LSD only. LSD analogue users described the effects as psychedelic (93%), over half (55%) obtained it online, and almost all (99%) reported an oral route of administration. The modal duration (8 hr) and time to peak (2 hr) of LSD analogues were not significantly different from LSD. Ratings for pleasurable high, strength of effect, comedown, urge to use more drugs, value for money, and risk of harm following use were significantly lower for LSD analogues compared with LSD. LSD analogues were reported as similar in time to peak and duration as LSD but weaker in strength, pleasurable high, and comedown. Future studies should seek to replicate these findings with chemical confirmation and dose measurement. Copyright © 2017 John Wiley & Sons, Ltd.

  10. Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil.

    Science.gov (United States)

    Lee, Ji Hyun; Park, Han Na; Park, Hyoung Joon; Kim, Nam Sook; Park, Sung-Kwan; Lee, Jongkook; Baek, Sun Young

    2018-01-01

    A new minoxidil analogue was detected in an illegal dietary supplement advertised as a hair-growth treatment. The analogue was identified using ultra-performance liquid chromatography (UPLC), high-resolution mass spectrometry (LC-HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. The compound was structurally elucidated as a minoxidil analogue in which the piperidinyl group of minoxidil was replaced with a pyrrolidinyl group corresponding to a molecular formula of C 8 H 13 N 5 O. The new analogue has been named triaminodil. As this is the first report of the compound, there are no chemical, toxicology or pharmacological data available.

  11. Geology and Habitability of Terrestrial Planets

    CERN Document Server

    Fishbaugh, Kathryn E; Raulin, François; Marais, David J; Korablev, Oleg

    2007-01-01

    Given the fundamental importance of and universal interest in whether extraterrestrial life has developed or could eventually develop in our solar system and beyond, it is vital that an examination of planetary habitability goes beyond simple assumptions such as, "Where there is water, there is life." This book has resulted from a workshop at the International Space Science Institute (ISSI) in Bern, Switzerland (5-9 September 2005) that brought together planetary geologists, geophysicists, atmospheric scientists, and biologists to discuss the multi-faceted problem of how the habitability of a planet co-evolves with the geology of the surface and interior, the atmosphere, and the magnetosphere. Each of the six chapters has been written by authors with a range of expertise so that each chapter is itself multi-disciplinary, comprehensive, and accessible to scientists in all disciplines. These chapters delve into what life needs to exist and ultimately to thrive, the early environments of the young terrestrial pl...

  12. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation.

    Science.gov (United States)

    Ongarora, Dennis S B; Gut, Jiri; Rosenthal, Philip J; Masimirembwa, Collen M; Chibale, Kelly

    2012-08-01

    The synthesis and evaluation of antiplasmodial activity of benzothiazole, benzimidazole, benzoxazole and pyridine analogues of amodiaquine is hereby reported. Benzothiazole and benzoxazole analogues with a protonatable tertiary nitrogen atom possessed excellent activity against the W2 and K1 chloroquine resistant strains of Plasmodium falciparum, with IC(50)s ranging from 7 to 22 nM. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. New analogues of Cucurbita maxima trypsin inhibitor III (CMTI III) with simplified structure.

    Science.gov (United States)

    Rolka, K; Kupryszewski, G; Rózycki, J; Ragnarsson, U; Zbyryt, T; Otlewski, J

    1992-10-01

    Seven new analogues of trypsin inhibitor CMTI III were obtained by solid-phase peptide synthesis. Three analogues contained only two, instead of three, disulfide bridges, whereas the molecules of the next four analogues were shortened at the N- and/or C-terminus. The elimination of one disulfide bridge in CMTI III induces a decrease in the association equilibrium constants by 6-7 orders of magnitude, whereas the removal of one, two or three amino-acid residues at the N- and/or C-terminus does not significantly affect the activity.

  14. 0+ analogue state in 118Sb from 117Sn(p,nγ) reaction

    International Nuclear Information System (INIS)

    Pal, J.; Dey, C.C.; Bose, S.; Sinha, B.K.; Chatterjee, M.B.; Mahapatra, D.P.

    1996-01-01

    The analogue of the 0 + ground state in 118 Sn has been observed in the compound nucleus 118 Sb through 117 Sn(p,nγ) 117 Sb reaction. The neutron decays of this analogue resonance have been studied from the deexciting γ-rays of the residual nucleus 117 Sb. From off resonance excitation functions, spin assignments have been made to states in 117 Sb, on the basis of Hauser-Feshbach formalism. The resonance parameters of the isobaric analogue resonance have been determined, including the total, proton and neutron decay widths. (orig.)

  15. Differential Top10 promoter regulation by six tetracycline analogues in plant cells

    Science.gov (United States)

    Love, John; Allen, George C.; Gatz, Christiane; Thompson, William F.; Brown, C. S. (Principal Investigator)

    2002-01-01

    The effects of five tetracycline analogues, anhydrotetracycline, doxycycline, minocycline, oxytetracycline, and tetracycline, on Top10 promoter activity in NT1 tobacco tissue culture cells have been analysed. The concentration that repressed Top10 promoter activity, the level of transgene repression and the kinetics of transgene de-repression were determined for each analogue, and could not be predicted from in vitro binding affinity to the tetracycline repressor or from comparison with animal cells. Doxycycline had the most potent effect on the Top10 promoter and completely inhibited transgene expression at 4 nmol l(-1). Tetracycline was the most versatile of the analogues tested; tetracycline inhibited the Top10 promoter at 10 nmol l(-1) and was easily washed out to restore Top10-driven expression in 12-24 h. A study was also made of the suitability for plant research of a novel tetracycline analogue, GR33076X. In animal cells, GR33076X de-repressed Top10 promoter activity in the presence of inhibitory concentrations of anhydrotetracycline. In NT1, it is shown that GR 33076X can antagonize repression of the Top10 promoter in the presence of tetracycline, but not of anhydrotetracycline or of doxycycline. Different tetracycline analogues can therefore be used to regulate the Top10 promoter in plant cells and this property may be exploited in planning an optimum course of transgene regulation.

  16. Emotions and Habitability study in Moon Mars Analogue.

    Science.gov (United States)

    Mertens, Alexandre; Lia Schlacht, Irene

    Euro Moon Mars mission have been conducted by students and field researchers in the Mars Desert Research Station (MDRS) a habitat installed by the Mars Society (MS) in the Utah desert. The campaign was supported by ILEWG International Lunar Exploration Working Group, ESTEC, NASA Ames, and partners. It investigated human aspects of isolation in a Mars analogue base. The project is in line with the ILEWG which coordinates several MDRS missions, and contributes to the preparation of future Mars sample return missions. The objective is to study and improve the habitat dynamics in a closed and small environment. Investigation cover different fields as emotional, sociological and psychological aspects and a food study but also habitability aspects. The study has been conducted by asking to the crew members to perform task and fill in questionnaires before, during and after the simulation. Video recovering, pictures and heart rate counting will also be used. One of the main study subject, conducted by Bernard Rimé, concerns the sharing of emotions in an isolated environ-e ment. Another is "Mars Habitability Experiment", which responsible is Irene Schlacht, will try to determine whether humans need variability of stimuli such as it happens in the natural environment -e.g. seasonal changing -to gain efficiency, reliability and well-being. This study have been conducted from February 19 to April 19 on two crews presenting different aspects that could lead to various behaviours. The first crew is made of people from different countries that don't know each other very well. On the opposite, the second crew members have the same cultural background -they come from the same country, university -and they know each other for at least six months. This allow studying how the extreme conditions of the isolation affect the crew efficiency, creativity and sanity according to its homogeneity. Report on the science and technical results, and implications for Earth-Mars comparative stud

  17. Denitrifying bacteria from the terrestrial subsurface exposed to mixed waste contamination

    International Nuclear Information System (INIS)

    Green, Stefan; Prakash, Om; Gihring, Thomas; Akob, Denise M.; Jasrotia, Puja; Jardine, Philip M.; Watson, David B.; Brown, Steven David; Palumbo, Anthony Vito; Kostka, Joel

    2010-01-01

    In terrestrial subsurface environments where nitrate is a critical groundwater contaminant, few cultivated representatives are available with which to verify the metabolism of organisms that catalyze denitrification. In this study, five species of denitrifying bacteria from three phyla were isolated from subsurface sediments exposed to metal radionuclide and nitrate contamination as part of the U.S. Department of Energy's Oak Ridge Integrated Field Research Challenge (OR-IFRC). Isolates belonged to the genera Afipia and Hyphomicrobium (Alphaproteobacteria), Rhodanobacter (Gammaproteobacteria), Intrasporangium (Actinobacteria) and Bacillus (Firmicutes). Isolates from the phylum Proteobacteria were confirmed as complete denitrifiers, whereas the Gram-positive isolates reduced nitrate to nitrous oxide. Ribosomal RNA gene analyses reveal that bacteria from the genus Rhodanobacter comprise a diverse population of circumneutral to moderately acidophilic denitrifiers at the ORIFRC site, with a high relative abundance in areas of the acidic source zone. Rhodanobacter species do not contain a periplasmic nitrite reductase and have not been previously detected in functional gene surveys of denitrifying bacteria at the OR-IFRC site. Sequences of nitrite and nitrous oxide reductase genes were recovered from the isolates and from the terrestrial subsurface by designing primer sets mined from genomic and metagenomic data and from draft genomes of two of the isolates. We demonstrate that a combination of cultivation, genomic and metagenomic data are essential to the in situ characterization of denitrifiers and that current PCR-based approaches are not suitable for deep coverage of denitrifying microorganisms. Our results indicate that the diversity of denitrifiers is significantly underestimated in the terrestrial subsurface.

  18. Kahalalide F analogues from the mucous secretion of Indian sacoglossan mollusc Elysia ornata

    Digital Repository Service at National Institute of Oceanography (India)

    Ciavatta, M.L.; PrabhaDevi; Carbone, M.; Mathieu, V.; Kiss, R.; Casapullo, A.; Gavagnin, M.

    , better delivery, or longer half-life. More than 150 analogues were obtained by solid phase peptide synthesis8,9 and more recently a semi-synthetic approach to produce KF analogues starting from natural KF has been also performed.10In parallel...

  19. Systematic Review of the Cost Effectiveness of Insulin Analogues in Type 1 and Type 2 Diabetes Mellitus.

    Science.gov (United States)

    Shafie, Asrul Akmal; Ng, Chin Hui; Tan, Yui Ping; Chaiyakunapruk, Nathorn

    2017-02-01

    Insulin analogues have a pharmacokinetic advantage over human insulin and are increasingly used to treat diabetes mellitus. A summary of their cost effectiveness versus other available treatments was required. Our objective was to systematically review the published cost-effectiveness studies of insulin analogues for the treatment of patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). We searched major databases and health technology assessment agency reports for economic evaluation studies published up until 30 September 2015. Two reviewers performed data extraction and assessed the quality of the data using the CHEERS (Consolidated Health Economic Evaluation Reporting Standards) guidelines. Seven of the included studies assessed short-acting insulin analogues, 12 assessed biphasic insulin analogues, 30 assessed long-acting insulin analogues and one assessed a combination of short- and long-acting insulin analogues. Only 17 studies involved patients with T1DM, all were modelling studies and 12 were conducted in Canada. The incremental cost-effectiveness ratios (ICERs) for short-acting insulin analogues ranged from dominant to $US435,913 per quality-adjusted life-year (QALY) gained, the ICERs for biphasic insulin analogues ranged from dominant to $US57,636 per QALY gained and the ICERs for long-acting insulin analogues ranged from dominant to $US599,863 per QALY gained. A total of 15 studies met all the CHEERS guidelines reporting quality criteria. Only 26 % of the studies assessed heterogeneity in their analyses. Current evidence indicates that insulin analogues are cost effective for T1DM; however, evidence for their use in T2DM is not convincing. Additional evidence regarding compliance and efficacy is required to support the broader use of long-acting and biphasic insulin analogues in T2DM. The value of insulin analogues depends strongly on reductions in hypoglycaemia event rates and its efficacy in lowering glycated haemoglobin

  20. Comparison of Directionally Solidified Samples Solidified Terrestrially and Aboard the International Space Station

    Science.gov (United States)

    Angart, S.; Lauer, M.; Tewari, S. N.; Grugel, R. N.; Poirier, D. R.

    2014-01-01

    This article reports research that has been carried out under the aegis of NASA as part of a collaboration between ESA and NASA for solidification experiments on the International Space Station (ISS). The focus has been on the effect of convection on the microstructural evolution and macrosegregation in hypoeutectic Al-Si alloys during directional solidification (DS). Terrestrial DS-experiments have been carried out at Cleveland State University (CSU) and under microgravity on the International Space Station (ISS). The thermal processing-history of the experiments is well defined for both the terrestrially processed samples and the ISS-processed samples. As of this writing, two dendritic metrics was measured: primary dendrite arm spacings and primary dendrite trunk diameters. We have observed that these dendrite-metrics of two samples grown in the microgravity environment show good agreements with models based on diffusion controlled growth and diffusion controlled ripening, respectively. The gravity-driven convection (i.e., thermosolutal convection) in terrestrially grown samples has the effect of decreasing the primary dendrite arm spacings and causes macrosegregation. Dendrite trunk diameters also show differences between the earth- and space-grown samples. In order to process DS-samples aboard the ISS, the dendritic seed crystals were partially remelted in a stationary thermal gradient before the DS was carried out. Microstructural changes and macrosegregation effects during this period are described and have modeled.

  1. Soil and terrestrial biology studies

    International Nuclear Information System (INIS)

    Anon.

    1976-01-01

    Soil and terrestrial biology studies focused on developing an understanding of the uptake of gaseous substances from the atmosphere by plants, biodegradation of oil, and the movement of Pu in the terrestrial ecosystems of the southeastern United States. Mathematical models were developed for SO 2 and tritium uptake from the atmosphere by plants; the uptake of tritium by soil microorganisms was measured; and the relationships among the Pu content of soil, plants, and animals of the Savannah River Plant area were studied. Preliminary results are reported for studies on the biodegradation of waste oil on soil surfaces

  2. Impact of the earthworm Lumbricus terrestris (L.) on As, Cu, Pb and Zn mobility and speciation in contaminated soils

    International Nuclear Information System (INIS)

    Sizmur, Tom; Palumbo-Roe, Barbara; Watts, Michael J.; Hodson, Mark E.

    2011-01-01

    To assess the risks that contaminated soils pose to the environment properly a greater understanding of how soil biota influence the mobility of metal(loid)s in soils is required. Lumbricus terrestris L. were incubated in three soils contaminated with As, Cu, Pb and Zn. The concentration and speciation of metal(loid)s in pore waters and the mobility and partitioning in casts were compared with earthworm-free soil. Generally the concentrations of water extractable metal(loid)s in earthworm casts were greater than in earthworm-free soil. The impact of the earthworms on concentration and speciation in pore waters was soil and metal specific and could be explained either by earthworm induced changes in soil pH or soluble organic carbon. The mobilisation of metal(loid)s in the environment by earthworm activity may allow for leaching or uptake into biota. - Research highlights: → Earthworms increase the mobility and availability of metals and metalloids in soils. → We incubated L. terrestris in three soils contaminated with As, Cu, Pb and Zn. → Earthworms increased the mobility of As, Cu, Pb and Zn in their casts. → The mechanisms for this could be explained by changes in pH or organic carbon. - Lumbricus terrestris change the partitioning of metal(loid)s between soil constituents and increase the mobility of metal(loid)s in casts and pore water.

  3. Impact of the earthworm Lumbricus terrestris (L.) on As, Cu, Pb and Zn mobility and speciation in contaminated soils

    Energy Technology Data Exchange (ETDEWEB)

    Sizmur, Tom, E-mail: t.p.sizmur@reading.ac.uk [Soil Research Centre, Department of Geography and Environmental Science, School of Human and Environmental Sciences, University of Reading, Whiteknights, Reading RG6 6DW (United Kingdom); Palumbo-Roe, Barbara; Watts, Michael J. [British Geological Survey, Kingsley Dunham Centre, Keyworth, Nottingham NG12 5GG (United Kingdom); Hodson, Mark E. [Soil Research Centre, Department of Geography and Environmental Science, School of Human and Environmental Sciences, University of Reading, Whiteknights, Reading RG6 6DW (United Kingdom)

    2011-03-15

    To assess the risks that contaminated soils pose to the environment properly a greater understanding of how soil biota influence the mobility of metal(loid)s in soils is required. Lumbricus terrestris L. were incubated in three soils contaminated with As, Cu, Pb and Zn. The concentration and speciation of metal(loid)s in pore waters and the mobility and partitioning in casts were compared with earthworm-free soil. Generally the concentrations of water extractable metal(loid)s in earthworm casts were greater than in earthworm-free soil. The impact of the earthworms on concentration and speciation in pore waters was soil and metal specific and could be explained either by earthworm induced changes in soil pH or soluble organic carbon. The mobilisation of metal(loid)s in the environment by earthworm activity may allow for leaching or uptake into biota. - Research highlights: > Earthworms increase the mobility and availability of metals and metalloids in soils. > We incubated L. terrestris in three soils contaminated with As, Cu, Pb and Zn. > Earthworms increased the mobility of As, Cu, Pb and Zn in their casts. > The mechanisms for this could be explained by changes in pH or organic carbon. - Lumbricus terrestris change the partitioning of metal(loid)s between soil constituents and increase the mobility of metal(loid)s in casts and pore water.

  4. The early evolution of the atmospheres of terrestrial planets

    CERN Document Server

    Raulin, François; Muller, Christian; Nixon, Conor; Astrophysics and Space Science Proceedings : Volume 35

    2013-01-01

    “The Early Evolution of the Atmospheres of Terrestrial Planets” presents the main processes participating in the atmospheric evolution of terrestrial planets. A group of experts in the different fields provide an update of our current knowledge on this topic. Several papers in this book discuss the key role of nitrogen in the atmospheric evolution of terrestrial planets. The earliest setting and evolution of planetary atmospheres of terrestrial planets is directly associated with accretion, chemical differentiation, outgassing, stochastic impacts, and extremely high energy fluxes from their host stars. This book provides an overview of the present knowledge of the initial atmospheric composition of the terrestrial planets. Additionally it includes some papers about the current exoplanet discoveries and provides additional clues to our understanding of Earth’s transition from a hot accretionary phase into a habitable world. All papers included were reviewed by experts in their respective fields. We are ...

  5. Optical Proxies for Terrestrial Dissolved Organic Matter in Estuaries and Coastal Waters

    Directory of Open Access Journals (Sweden)

    Christopher L. Osburn

    2016-01-01

    Full Text Available Optical proxies, especially DOM fluorescence, were used to track terrestrial DOM fluxes through estuaries and coastal waters by comparing models developed for several coastal ecosystems. Key to using optical properties is validating and calibrating them with chemical measurements, such as lignin-derived phenols - a proxy to quantify terrestrial DOM. Utilizing parallel factor analysis (PARAFAC, and comparing models statistically using the OpenFluor database (http://www.openfluor.org we have found common, ubiquitous fluorescing components which correlate most strongly with lignin phenol concentrations in several estuarine and coastal environments. Optical proxies for lignin were computed for the following regions: Mackenzie River Estuary, Atchafalaya River Estuary, Charleston Harbor, Chesapeake Bay, and Neuse River Estuary. The slope of linear regression models relating CDOM absorption at 350 nm (a350 to DOC and to lignin, varied 5 to 10 fold among systems. Where seasonal observations were available from a region, there were distinct seasonal differences in equation parameters for these optical proxies. Despite variability, overall models using single linear regression were developed that related dissolved organic carbon (DOC concentration to CDOM (DOC = 40×a350+138; R2 = 0.77; N = 130 and lignin (Σ8 to CDOM (Σ8 = 2.03×a350-0.5; R2 = 0.87; N = 130. This wide variability suggested that local or regional optical models should be developed for predicting terrestrial DOM flux into coastal oceans and taken into account when upscaling to remote sensing observations and calibrations.

  6. From boron analogues of amino acids to boronated DNA: potential new pharmaceuticals and neutron capture agents

    International Nuclear Information System (INIS)

    Spielvogel, B.F.; Sood, Anup; Duke Univ., Durham, NC; Shaw, B.R.; Hall, I.H.

    1991-01-01

    Isoelectronic and isostructural boron analogues of the α-amino acids ranging from simple glycine analogues such as H 3 NBH 2 COOH and Me 2 NHBH 2 COOH to alanine analogues have been synthesised. A diverse variety of analogues, including precursors and derivatives (such as peptides) have potent pharmacological activity, including anticancer, antiinflammatory, analgesic, and hypolipidemic activity in animal model studies and in vitro cell cultures. Boronated nucleosides and (oligo)nucleotides, synthetic oligonucleotide analogues of ''antisense'' agents interact with a complementary nucleic acid sequence blocking the biological effect of the target sequence. Nucleosides boronated on the pyrimidine and purine bases have been prepared. It has been established that an entirely new class of nucleic acid derivatives is feasible in which one of the non-bridging oxygens in the internucleotide phosphodiester linkage can be replaced by an isoelectronic analogue, the borane group, (BH 3 ). The boronated oligonucleotides can be viewed as hybrids of the normal oxygen oligonucleotides and the methylphosphonate oligonucleotides. (author)

  7. A Pliocene marine diatom δ18O record of terrestrial-marine feedbacks and orbitally-paced cryogenic brine formation in the McMurdo Dry Valleys

    Science.gov (United States)

    Dodd, J. P.; Abbott, T.; Gibbons, J. A.

    2017-12-01

    Orbital frequencies are well documented in a number of terrestrial and marine climate records throughout the Cenozoic; however, assessing the feedbacks and timing of terrestrial-marine systems on glacial-interglacial timescales is often challenging. This is particularly the case in high-latitude, near-shore environments where traditional proxy records like benthic foraminifera are absent. Here we present oxygen isotope (δ18O and δ17O) values from marine diatom silica in the mid-Pliocene (3.5 - 4.7Ma) section of the AND-1B core from McMurdo Sound, Antarctica. Diatom silica δ18O values range between +28.1 and +36.4‰ VSMOW. Over a range of temperatures (0 to 10°C) that reflect both growth and shallow (fall on a mixing line between marine and meteoric waters, which also supports our cryogenic brine hypothesis. The AND-1B δ18O values have an inverse relationship with the stacked benthic foraminifera δ18O record where lower δ18O values in the AND-1B diatom silica correspond with colder intervals, and we interpret variations in the diatom δ18O values as increased brine flux from the MDV to McMurdo Sound. Currently, subsurface brines in the MDV are hydrologically connected with McMurdo Sound. Density-driven transport of these brines from the MDV to the marine costal environments during the warm mid-Pliocene indicate a potentially overlooked terrestrial source of hypersaline waters. Although the lateral extent of these brines is not known, mixing between the terrestrial cryogenic brines and seawater may represent a significant flux of hypersaline water to the marine environment during warmer-than-present global conditions.

  8. Insulin biosimilars: the impact on rapid-acting analogue-based therapy.

    Science.gov (United States)

    Franzè, S; Cilurzo, F; Minghetti, P

    2015-04-01

    The impending expiration of patent protection for recombinant insulins provides the opportunity to introduce cost-saving copies, named biosimilars, onto the market. Although there is broad experience in the production and characterisation of insulins, the development of copies is still a challenge. In this paper, the main features of insulins and the EU regulatory framework for their biosimilar products are reviewed. The main focus is on rapid-acting insulin analogues (Humalog(®); Novolog(®)/NovoRapid(®); Apidra(®)). Since they differ by one or two amino acids in chain B, production of one biosimilar for all three drug products is not feasible. However, from post-marketing-collected clinical data, rapid-acting insulin analogues seem to have similar therapeutic efficacy. It is reasonable to suppose that, for prescription to treatment-naïve patients, the cheaper biosimilar would be the preferred choice of physicians, either spontaneously or induced by health insurance. Therefore, its introduction will affect the market share of all the other rapid-acting insulin analogues.

  9. Water vapor estimation using digital terrestrial broadcasting waves

    Science.gov (United States)

    Kawamura, S.; Ohta, H.; Hanado, H.; Yamamoto, M. K.; Shiga, N.; Kido, K.; Yasuda, S.; Goto, T.; Ichikawa, R.; Amagai, J.; Imamura, K.; Fujieda, M.; Iwai, H.; Sugitani, S.; Iguchi, T.

    2017-03-01

    A method of estimating water vapor (propagation delay due to water vapor) using digital terrestrial broadcasting waves is proposed. Our target is to improve the accuracy of numerical weather forecast for severe weather phenomena such as localized heavy rainstorms in urban areas through data assimilation. In this method, we estimate water vapor near a ground surface from the propagation delay of digital terrestrial broadcasting waves. A real-time delay measurement system with a software-defined radio technique is developed and tested. The data obtained using digital terrestrial broadcasting waves show good agreement with those obtained by ground-based meteorological observation. The main features of this observation are, no need for transmitters (receiving only), applicable wherever digital terrestrial broadcasting is available and its high time resolution. This study shows a possibility to estimate water vapor using digital terrestrial broadcasting waves. In the future, we will investigate the impact of these data toward numerical weather forecast through data assimilation. Developing a system that monitors water vapor near the ground surface with time and space resolutions of 30 s and several kilometers would improve the accuracy of the numerical weather forecast of localized severe weather phenomena.

  10. Current and future impacts of ultraviolet radiation on the terrestrial carbon balance

    Institute of Scientific and Technical Information of China (English)

    W. Kolby SMITH; Wei GAO; Heidi STELTZER

    2009-01-01

    One of the most documented effects of human activity on our environment is the reduction of stratospheric ozone resulting in an increase of biologically harmful ultraviolet (UV) radiation. In a less predictable manner, UV radiation incident at the surface of the earth is expected to be further modified in the future as a result of altered cloud condition, atmospheric aerosol concentration, and snow cover. Although UV radiation comprises only a small fraction of the total solar radiation that is incident at the earth's surface, it has the greatest energy per unit wavelength and, thus, the greatest potential to damage the biosphere. Recent investigations have highlighted numerous ways that UV radiation could potentially affect a variety of ecological processes, including nutrient cycling and the terrestrial carbon cycle. The objectives of the following literature review are to summarize and synthesize the available information relevant to the effects of UV radiation and other climate change factors on the terrestrial carbon balance in an effort to highlight current gaps in knowledge and future research directions for UV radiation research.

  11. Andrographolide and analogues in cancer prevention.

    Science.gov (United States)

    Mishra, Siddhartha Kumar; Tripathi, Swati; Shukla, Archana; Oh, Seung Hyun; Kim, Hwan Mook

    2015-01-01

    Andrographis paniculata is a medicinal plant traditionally used for treatment of cough and cold, fever, laryngitis, and several infectious diseases. Extracts of A. paniculata have shown versatile potency against various diseases including cancer. The active biomolecules of A. paniculata mainly are lactone and diterpene. Andrographolide and analogues have been widely used for prevention of different diseases. Andrographolides have shown potent antiinflammatory and anticancer activities. It showed potentials as chemopreventive agents by suppressing growth of cancer cells by inhibiting NF-kappaB, PI3K/AKT and other kinase pathways and by inducing apoptosis. Andrographolide induced both intrinsic and extrinsic apoptosis pathway in different cancer cells via expression of different anti-apoptotic protein like Bax, p53, and activated caspases. Andrographolide was successfully used as an antineoplastic drug in cancer chemotherapy. Andrographolide inhibited the growth of human breast, prostate, and hepatoma tumors. Andrographolide and analogues need to be subjected to further clinical and biomedical studies in cancer chemoprevention. Andrographolide could be potent anticancer agent when used in combination with other chemotherapeutic agents.

  12. The monoamine oxidase inhibition properties of selected structural analogues of methylene blue

    International Nuclear Information System (INIS)

    Delport, Anzelle; Harvey, Brian H.; Petzer, Anél; Petzer, Jacobus P.

    2017-01-01

    The thionine dye, methylene blue (MB), is a potent inhibitor of monoamine oxidase (MAO) A, a property that may, at least in part, mediate its antidepressant effects in humans and animals. The central inhibition of MAO-A by MB has also been linked to serotonin toxicity (ST) which may arise when MB is used in combination with serotonergic drugs. Structural analogues and the principal metabolite of MB, azure B, have also been reported to inhibit the MAO enzymes, with all compounds exhibiting specificity for the MAO-A isoform. To expand on the structure-activity relationships (SARs) of MAO inhibition by MB analogues, the present study investigates the human MAO inhibition properties of five MB analogues: neutral red, Nile blue, new methylene blue, cresyl violet and 1,9-dimethyl methylene blue. Similar to MB, these analogues also are specific MAO-A inhibitors with cresyl violet (IC 50 = 0.0037 μM), Nile blue (IC 50 = 0.0077 μM) and 1,9-dimethyl methylene blue (IC 50 = 0.018 μM) exhibiting higher potency inhibition compared to MB (IC 50 = 0.07 μM). Nile blue also represents a potent MAO-B inhibitor with an IC 50 value of 0.012 μM. From the results it may be concluded that non-thionine MB analogues (e.g. cresyl violet and Nile blue) also may exhibit potent MAO inhibition, a property which should be considered when using these compounds in pharmacological studies. Benzophenoxazines such as cresyl violet and Nile blue are, similar to phenothiazines (e.g. MB), representative of high potency MAO-A inhibitors with a potential risk of ST. - Highlights: • MB analogues, cresyl violet and Nile blue, are high potency MAO-A inhibitors. • Nile blue also represents a potent MAO-B inhibitor. • Potent MAO-A inhibition should alert to potential serotonin toxicity.

  13. The monoamine oxidase inhibition properties of selected structural analogues of methylene blue

    Energy Technology Data Exchange (ETDEWEB)

    Delport, Anzelle [Pharmaceutical Chemistry, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom 2520 (South Africa); Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520 (South Africa); Harvey, Brian H. [Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520 (South Africa); Pharmacology, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom 2520 (South Africa); Petzer, Anél [Pharmaceutical Chemistry, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom 2520 (South Africa); Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520 (South Africa); Petzer, Jacobus P., E-mail: jacques.petzer@nwu.ac.za [Pharmaceutical Chemistry, School of Pharmacy, North-West University, Private Bag X6001, Potchefstroom 2520 (South Africa); Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520 (South Africa)

    2017-06-15

    The thionine dye, methylene blue (MB), is a potent inhibitor of monoamine oxidase (MAO) A, a property that may, at least in part, mediate its antidepressant effects in humans and animals. The central inhibition of MAO-A by MB has also been linked to serotonin toxicity (ST) which may arise when MB is used in combination with serotonergic drugs. Structural analogues and the principal metabolite of MB, azure B, have also been reported to inhibit the MAO enzymes, with all compounds exhibiting specificity for the MAO-A isoform. To expand on the structure-activity relationships (SARs) of MAO inhibition by MB analogues, the present study investigates the human MAO inhibition properties of five MB analogues: neutral red, Nile blue, new methylene blue, cresyl violet and 1,9-dimethyl methylene blue. Similar to MB, these analogues also are specific MAO-A inhibitors with cresyl violet (IC{sub 50} = 0.0037 μM), Nile blue (IC{sub 50} = 0.0077 μM) and 1,9-dimethyl methylene blue (IC{sub 50} = 0.018 μM) exhibiting higher potency inhibition compared to MB (IC{sub 50} = 0.07 μM). Nile blue also represents a potent MAO-B inhibitor with an IC{sub 50} value of 0.012 μM. From the results it may be concluded that non-thionine MB analogues (e.g. cresyl violet and Nile blue) also may exhibit potent MAO inhibition, a property which should be considered when using these compounds in pharmacological studies. Benzophenoxazines such as cresyl violet and Nile blue are, similar to phenothiazines (e.g. MB), representative of high potency MAO-A inhibitors with a potential risk of ST. - Highlights: • MB analogues, cresyl violet and Nile blue, are high potency MAO-A inhibitors. • Nile blue also represents a potent MAO-B inhibitor. • Potent MAO-A inhibition should alert to potential serotonin toxicity.

  14. The PedsQL™ Present Functioning Visual Analogue Scales: preliminary reliability and validity

    Directory of Open Access Journals (Sweden)

    Varni James W

    2006-10-01

    Full Text Available Abstract Background The PedsQL™ Present Functioning Visual Analogue Scales (PedsQL™ VAS were designed as an ecological momentary assessment (EMA instrument to rapidly measure present or at-the-moment functioning in children and adolescents. The PedsQL™ VAS assess child self-report and parent-proxy report of anxiety, sadness, anger, worry, fatigue, and pain utilizing six developmentally appropriate visual analogue scales based on the well-established Varni/Thompson Pediatric Pain Questionnaire (PPQ Pain Intensity VAS format. Methods The six-item PedsQL™ VAS was administered to 70 pediatric patients ages 5–17 and their parents upon admittance to the hospital environment (Time 1: T1 and again two hours later (Time 2: T2. It was hypothesized that the PedsQL™ VAS Emotional Distress Summary Score (anxiety, sadness, anger, worry and the fatigue VAS would demonstrate moderate to large effect size correlations with the PPQ Pain Intensity VAS, and that patient" parent concordance would increase over time. Results Test-retest reliability was demonstrated from T1 to T2 in the large effect size range. Internal consistency reliability was demonstrated for the PedsQL™ VAS Total Symptom Score (patient self-report: T1 alpha = .72, T2 alpha = .80; parent proxy-report: T1 alpha = .80, T2 alpha = .84 and Emotional Distress Summary Score (patient self-report: T1 alpha = .74, T2 alpha = .73; parent proxy-report: T1 alpha = .76, T2 alpha = .81. As hypothesized, the Emotional Distress Summary Score and Fatigue VAS were significantly correlated with the PPQ Pain VAS in the medium to large effect size range, and patient and parent concordance increased from T1 to T2. Conclusion The results demonstrate preliminary test-retest and internal consistency reliability and construct validity of the PedsQL™ Present Functioning VAS instrument for both pediatric patient self-report and parent proxy-report. Further field testing is required to extend these initial

  15. The IAEA report on the role of natural analogues in performance assessment

    International Nuclear Information System (INIS)

    Vovk, I.F.

    1989-01-01

    A working draft of the report was prepared with the assistance of a group of consultants who met in Vienna from 29 June to 3 July 1987. The draft was revised by an Advisory Group meeting in Vienna from 2 to 6 November 1987 and examined by the Technical Review Committee on Underground Disposal of Radioactive Waste (TRCUD) convened in Vienna from 15 to 19 February 1988. TRCUD recommended it for publication as a Technical Reports Series. The document appraises the use of natural analogues in improving confidence in the soundness of performance assessments for deep underground disposal of long-lived wastes. For this purpose it reviews several available performance assessments and identifies on this basis factors, processes or parameters which are important to their results, assesses the requirements for validation in each area and identifies those areas where analogues are appropriate. A special section is devoted to discussion of the quantitative and qualitative roles of the analogues. A number of conclusions reflect the state-of-the-art and may guide further natural analogue studies

  16. Combinatorial Solid-Phase Synthesis of Balanol Analogues

    DEFF Research Database (Denmark)

    Nielsen, John; Lyngsø, Lars Ole

    1996-01-01

    The natural product balanol has served as a template for the design and synthesis of a combinatorial library using solid-phase chemistry. Using a retrosynthetic analysis, the structural analogues have been assembled from three relatively accessible building blocks. The solid-phase chemistry inclu...

  17. DOTA-derivatives of octreotide dicarba-analogues with high affinity for somatostatin sst2,5 receptors

    Science.gov (United States)

    Pratesi, Alessandro; Ginanneschi, Mauro; Lumini, Marco; Papini, Anna M.; Novellino, Ettore; Brancaccio, Diego; Carotenuto, Alfonso

    2017-02-01

    In vivo somatostatin receptor scintigraphy is a valuable method for the visualization of human endocrine tumours and their metastases. In fact, peptide ligands of somatostatin receptors (sst’s) conjugated with chelating agents are in clinical use. We have recently developed octreotide dicarba-analogues, which show interesting binding profiles at sst’s. In this context, it was mandatory to explore the possibility that our analogues could maintain their activity also upon conjugation with DOTA. In this paper, we report and discuss the synthesis, binding affinity and conformational preferences of three DOTA-conjugated dicarba-analogues of octreotide. Interestingly, two conjugated analogues exhibited nanomolar affinities on sst2 and sst5 somatostatin receptor subtypes.

  18. The decadal state of the terrestrial carbon cycle

    NARCIS (Netherlands)

    Velde, van der I.R.; Bloom, J.; Exbrayat, J.; Feng, L.; Williams, M.

    2016-01-01

    The terrestrial carbon cycle is currently the least constrained component of the global carbon budget. Large uncertainties stem from a poor understanding of plant carbon allocation, stocks, residence times, and carbon use efficiency. Imposing observational constraints on the terrestrial carbon cycle

  19. Neurochemical binding profiles of novel indole and benzofuran MDMA analogues.

    OpenAIRE

    Shimshoni, JA; Winkler, I; Golan, E; Nutt, D

    2016-01-01

    3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical trials. In the present study, we have characterized the neurochemical binding profiles of three MDMA-benzofuran analogues (1-(benzofuran-5-yl)-propan-2-amine, 5-APB; 1-(benzofuran-6-yl)-N-methylpropan-2-amine, 6-MAPB; 1-(benzofuran-5-yl)-N-methylpropan-2-amine, 5-MAPB) and one MDMA-indole analogue (1-(1H-indol-5-yl)-2-methylamino-propan-1-...

  20. Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6.

    Science.gov (United States)

    Bajusz, S; Janaky, T; Csernus, V J; Bokser, L; Fekete, M; Srkalovic, G; Redding, T W; Schally, A V

    1989-08-01

    The nitrogen mustard derivatives of 4-phenylbutyric acid and L-phenylalanine, called chlorambucil (Chl) and melphalan (Mel), respectively, have been incorporated into several peptide hormones, including luteinizing hormone-releasing hormone (LH-RH). The alkylating analogues of LH-RH were prepared by linking Chl, as an N-acyl moiety, to the complete amino acid sequence of agonistic and antagonistic analogues. These compounds, in particular the antagonistic analogues, showed much lower potency than their congeners carrying other acyl groups. To obtain highly potent alkylating analogues of LH-RH, the D enantiomer of Mel was incorporated into position 6 of the native hormone and some of its antagonistic analogues. Of the peptides prepared, [D-Mel6]LH-RH (SB-05) and [Ac-D-Nal(2)1,D-Phe(pCl)2,D-Pal(3)3,Arg5,D-Mel6,D-Ala10++ +]LH-RH [SB-86, where Nal(2) is 3-(2-naphthyl)alanine and Pal(3) is 3-(3-pyridyl)alanine] possessed the expected high agonistic and antagonistic activities, respectively, and also showed high affinities for the membrane receptors of rat pituitary cells, human breast cancer cells, human prostate cancer cells, and rat Dunning R-3327 prostate tumor cells. These two analogues exerted cytotoxic effects on human and rat mammary cancer cells in vitro. Thus these two D-Mel6 analogues seem to be particularly suitable for the study of how alkylating analogues of LH-RH could interfere with intracellular events in certain cancer cells.