WorldWideScience

Sample records for terbium 158

  1. Elastic properties of terbium

    DEFF Research Database (Denmark)

    Spichkin, Y.I.; Bohr, Jakob; Tishin, A.M.

    1996-01-01

    The temperature dependence of the Young modulus along the crystallographic axes b and c (E(b) and E(c)), and the internal friction of a terbium single crystal have been measured. At 4.2 K, E(b) and E(c) are equal to 38 and 84.5 GPa, respectively. The lattice part of the Young modulus and the Debye...... temperature has been calculated. The origin of the Young modulus anomalies arising at the transition to the magnetically ordered state is discussed....

  2. Critical scattering of neutrons from terbium

    DEFF Research Database (Denmark)

    Als-Nielsen, Jens Aage; Dietrich, O.W.; Marshall, W.

    1968-01-01

    The inelasticity of the critical scattering of neutrons in terbium has been measured above the Neél temperature at the (0, 0, 2−Q) satellite position. The results show that dynamic slowing down of the fluctuations does occur in a second‐order phase transition in agreement with the general theory...

  3. Semiconductor composition containing iron, dysprosium, and terbium

    Energy Technology Data Exchange (ETDEWEB)

    Pooser, Raphael C.; Lawrie, Benjamin J.; Baddorf, Arthur P.; Malasi, Abhinav; Taz, Humaira; Farah, Annettee E.; Kalyanaraman, Ramakrishnan; Duscher, Gerd Josef Mansfred; Patel, Maulik K.

    2017-09-26

    An amorphous semiconductor composition includes 1 to 70 atomic percent iron, 15 to 65 atomic percent dysprosium, 15 to 35 atomic percent terbium, balance X, wherein X is at least one of an oxidizing element and a reducing element. The composition has an essentially amorphous microstructure, an optical transmittance of at least 50% in at least the visible spectrum and semiconductor electrical properties.

  4. Raman spectroscopy study of the doping effect of the encapsulated terbium halogenides on single-walled carbon nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Kharlamova, M.V.; Kramberger, C.; Mittelberger, A. [University of Vienna, Faculty of Physics, Vienna (Austria)

    2017-04-15

    In the present work, the doping effect of terbium chloride, terbium bromide, and terbium iodide on single-walled carbon nanotubes (SWCNTs) was compared by Raman spectroscopy. A precise investigation of the doping-induced alterations of the Raman modes of the filled SWCNTs was conducted. The shifts of the components of the Raman modes and modification of their profiles allowed concluding that the inserted terbium halogenides have acceptor doping effect on the SWCNTs, and the doping efficiency increases in the line with terbium iodide, terbium bromide, and terbium chloride. (orig.)

  5. Magnetocaloric effect of thin Terbium films

    Science.gov (United States)

    Mello, V. D.; Anselmo, D. H. A. L.; Vasconcelos, M. S.; Almeida, N. S.

    2017-12-01

    We report a theoretical study of the magnetocaloric effect of Terbium (Tb) thin films due to finite size and surface effects in the helimagnetic phase, corresponding to a temperature range from TC=219 K to TN=231 K, for external fields of the order of kOe. For a Tb thin film of 6 monolayers submitted to an applied field (ΔH =30 kOe, ΔH =50 kOe and ΔH = 70 kOe) we report a significative change in adiabatic temperature, ΔT / ΔH , near the Néel temperature, of the order ten times higher than that observed for Tb bulk. On the other hand, for small values of the magnetic field, large thickness effects are found. For external field strength around few kOe, we have found that the thermal caloric efficiency increases remarkably for ultrathin films. For an ultrathin film with 6 monolayers, we have found ΔT / ΔH = 43 K/T while for thicker films, with 20 monolayers, ΔT / ΔH = 22 K/T. Our results suggest that thin films of Tb are a promising material for magnetocaloric effect devices for applications at intermediate temperatures.

  6. Femtosecond XUV spectroscopy of gadolinium and terbium

    Energy Technology Data Exchange (ETDEWEB)

    Carley, Robert; Frietsch, Bjoern; Doebrich, Kristian; Teichmann, Martin; Gahl, Cornelius; Noack, Frank [Max-Born-Institute, Berlin (Germany); Schwarzkopf, Olaf; Wernet, Philippe [Helmholtz-Zentrum fuer Materialien und Energie (BESSY II), Berlin (Germany); Weinelt, Martin [Max-Born-Institute, Berlin (Germany); Fachbereich Physik, Freie Universitaet, Berlin (Germany)

    2011-07-01

    We present recent results of time-resolved IR-pump-XUV-probe experiments on the ultrafast demagnetization of thin films of Gadolinium(0001) and Terbium(0001) on Tungsten(110). The experiments are the first to be done using a newly developed high-order harmonics (HHG) XUV beamline at the MBI. The beamline delivers monochromated XUV pulses of approximately 150 fs duration with a photon energy resolution of up to 150 meV. Following excitation by intense femtosecond infrared (IR) pulses, photoemission with 35 eV photons allows us to directly probe the 4f electrons and their interaction with the valence band, both in the bulk and at the surface, to follow the ultrafast magnetization dynamics in the Lanthanide metals. As signatures of ultrafast demagnetization of the metal by the IR pulse, we see for the first time, rapid strong reduction of the exchange splitting in the valence band. This is followed by a slower demagnetization due to the spin-lattice interaction.

  7. Green fluorescence of terbium ions in lithium fluoroborate glasses ...

    Indian Academy of Sciences (India)

    Glasses; terbium ion; oscillator strengths; fluorescence; lifetimes; fibre lasers. 1. Introduction. Today glasses are most favourable engineering materials for abundant applications due to the wide ability of property altering by compositional modifications. The considerable examination of glass science to achieve required ...

  8. Green fluorescence of terbium ions in lithium fluoroborate glasses ...

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 39; Issue 3. Green fluorescence of terbium ions in lithium fluoroborate glasses for fibre lasers and display devices. G R DILLIP C MADHUKAR REDDY M RAJESH SHIVANAND CHAURASIA B DEVA PRASAD RAJU S W JOO. Volume 39 Issue 3 June 2016 pp 711-717 ...

  9. Terahertz Cherenkov radiation from ultrafast magnetization in terbium gallium garnet

    Science.gov (United States)

    Gorelov, S. D.; Mashkovich, E. A.; Tsarev, M. V.; Bakunov, M. I.

    2013-12-01

    We report an experimental observation of terahertz Cherenkov radiation from a moving magnetic moment produced in terbium gallium garnet by a circularly polarized femtosecond laser pulse via the inverse Faraday effect. Contrary to some existing theoretical predictions, the polarity of the observed radiation unambiguously demonstrates the paramagnetic, rather than diamagnetic, nature of the ultrafast inverse Faraday effect. From measurements of the radiation field, the Verdet constant in the subpicosecond regime is ˜3-10 times smaller than its table quasistatic value.

  10. Terbium luminescence in alumina xerogel fabricated in porous anodic alumina matrix under various excitation conditions

    Energy Technology Data Exchange (ETDEWEB)

    Gaponenko, N. V., E-mail: nik@nano.bsuir.edu.by [Belarusian State University of Informatics and Radioelectronics (Belarus); Kortov, V. S. [Yeltsin Ural Federal University (Russian Federation); Orekhovskaya, T. I.; Nikolaenko, I. A. [Belarusian State University of Informatics and Radioelectronics (Belarus); Pustovarov, V. A.; Zvonarev, S. V.; Slesarev, A. I. [Yeltsin Ural Federal University (Russian Federation); Prislopski, S. Ya. [National Academy of Sciences of Belarus, Stepanov Institute of Physics (Belarus)

    2011-07-15

    Terbium-doped alumina xerogel layers are synthesized by the sol-gel method in pores of a porous anodic alumina film 1 {mu}m thick with a pore diameter of 150-180 nm; the film is grown on a silicon substrate. The fabricated structures exhibit terbium photoluminescence with bands typical of trivalent terbium terms. Terbium X-ray luminescence with the most intense band at 542 nm is observed for the first time for such a structure. Morphological analysis of the structure by scanning electron microscopy shows the presence of xerogel clusters in pore channels, while the main pore volume remains unfilled and pore mouths remain open. The data obtained confirm the promising applications of fabricated structures for developing matrix converters of X-rays and other ionizing radiations into visible light. The possibilities of increasing luminescence intensity in the matrix converter are discussed.

  11. Optical Properties of Lithium Terbium Fluoride and Implications for Performance in High Power Lasers (Postprint)

    Science.gov (United States)

    2016-02-01

    AFRL-RX-WP-JA-2016-0323 OPTICAL PROPERTIES OF LITHIUM TERBIUM FLUORIDE AND IMPLICATIONS FOR PERFORMANCE IN HIGH POWER LASERS... AMERICA (STINFO COPY) AIR FORCE RESEARCH LABORATORY MATERIALS AND MANUFACTURING DIRECTORATE WRIGHT-PATTERSON AIR FORCE BASE, OH 45433-7750 AIR...OPTICAL PROPERTIES OF LITHIUM TERBIUM FLUORIDE AND IMPLICATIONS FOR PERFORMANCE IN HIGH POWER LASERS (POSTPRINT) 5a. CONTRACT NUMBER IN-HOUSE 5b

  12. 43 CFR 15.8 - Skin diving.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Skin diving. 15.8 Section 15.8 Public Lands: Interior Office of the Secretary of the Interior KEY LARGO CORAL REEF PRESERVE § 15.8 Skin diving. Diving with camera, or diving for observation and pleasure is permitted and encouraged within the...

  13. 40 CFR 158.30 - Flexibility.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Flexibility. 158.30 Section 158.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES General Provisions § 158.30 Flexibility. (a) FIFRA provides EPA flexibility to require...

  14. 40 CFR 158.1400 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Definitions. 158.1400 Section 158.1400... FOR PESTICIDES Residue Chemistry § 158.1400 Definitions. The following terms are defined for the.... Plant or animal metabolite means a pesticide chemical residue that is the result of biological breakdown...

  15. 44 CFR 15.8 - Gambling.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Gambling. 15.8 Section 15.8... CENTER § 15.8 Gambling. We prohibit participating in games for money or other personal property, including the operation of gambling devices, the conduct of a lottery or pool, or the sale or purchase of...

  16. 7 CFR 58.158 - Official identification.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Official identification. 58.158 Section 58.158... Official Identification § 58.158 Official identification. (a) Application for authority to apply official identification to packaging material or containers shall be made in accordance with the provisions of subpart A...

  17. Detection of biothiols in cells by a terbium chelate-Hg (II) system

    Science.gov (United States)

    Tan, Hongliang; Chen, Yang

    2012-01-01

    Great efforts have been devoted to the development of sensitive and specific analysis methods for biothiols because of their important roles in biological systems. We present a new detection system for biothiols that is based on the reversible quenching and restoration of fluorescence of terbium chelate caused by Hg2+ and thiol species. In the presence of biothiols, a restoration of fluorescence of terbium chelate after quenching by Hg2+ was observed due to the interaction of Hg2+ with thiol groups, and the restored fluorescence increased with the concentration of biothiols. This method was sensitive and selective for biothiols. The detection limit was 80 nM for glutathione, 100 nM for Hcy, and 400 nM for Cysteine, respectively. The terbium chelate-Hg (II) system was successfully applied to determine the levels of biothiols in cancer cells and urine samples. Further, it was also shown to be comparable to Ellman's assay. Compared to other fluorescence methods, the terbium chelate probe is advantageous because interference from short-lived nonspecific fluorescence can be efficiently eliminated due to the long fluorescence lifetime of terbium chelate, which allows for detection by time-resolved fluorescence. The terbium chelate probe can serve as a diagnostic tool for the detection of abnormal levels of biothiols in disease.

  18. Cryogenic temperature characteristics of Verdet constant of terbium sesquioxide ceramics

    Science.gov (United States)

    Snetkov, I. L.; Palashov, O. V.

    2016-12-01

    The dependence of the Verdet constant on temperature in the (80-300 K) range for a promising magneto-active material terbium sesquioxide Tb2O3 at the wavelengths of 405-1064 nm is considered. For each of the studied wavelengths, the Verdet constant of the material cooled down to the liquid nitrogen temperature increased by more than a factor of 3.2 as compared to the room temperature value. Similarly to the other paramagnetics, the increase follows the law ∼1/T. Approximations for the temperature dependence of the Verdet constant have been obtained and the value of 1/V·(dV/dT) has been estimated. This information is needed to determine the angle of rotation as well as the variation of the extinction ratio of a Faraday isolator with temperature and extremely important at creation a cryogenic Faraday devices.

  19. Biogenic terbium oxide nanoparticles as the vanguard against osteosarcoma

    Science.gov (United States)

    Iram, Sana; Khan, Salman; Ansary, Abu Ayoobul; Arshad, Mohd; Siddiqui, Sahabjada; Ahmad, Ejaz; Khan, Rizwan H.; Khan, Mohd Sajid

    2016-11-01

    The synthesis of inner transition metal nanoparticles via an ecofriendly route is quite difficult. This study, for the first time, reports synthesis of terbium oxide nanoparticles using fungus, Fusarium oxysporum. The biocompatible terbium oxide nanoparticles (Tb2O3 NPs) were synthesized by incubating Tb4O7 with the biomass of fungus F. oxysporum. Multiple physical characterization techniques, such as UV-visible and photoluminescence spectroscopy, TEM, SAED, and zeta-potential were used to confirm the synthesis, purity, optical and surface characteristics, crystallinity, size, shape, distribution, and stability of the nanoemulsion of Tb2O3 NPs. The Tb2O3 NPs were found to inhibit the propagation of MG-63 and Saos-2 cell-lines (IC50 value of 0.102 μg/mL) and remained non-toxic up to a concentration of 0.373 μg/mL toward primary osteoblasts. Cell viability decreased in a concentration-dependent manner upon exposure to 10 nm Tb2O3 NPs in the concentration range 0.023-0.373 μg/mL. Cell toxicity was evaluated by observing changes in cell morphology, cell viability, oxidative stress parameters, and FACS analysis. Morphological examinations of cells revealed cell shrinkage, nuclear condensation, and formation of apoptotic bodies. The level of ROS within the cells-an indicator of oxidative stress was significantly increased. The induction of apoptosis at concentrations ≤ IC50 was corroborated by 4‧,6-diamidino-2-phenylindole dihydrochloride (DAPI) staining (DNA damage and nuclear fragmentation). Flow-cytometric studies indicated that the response was dose dependent with a threshold effect.

  20. Characterization of E158 Beam

    Energy Technology Data Exchange (ETDEWEB)

    Farrell, Joe

    2003-09-05

    Stanford Linear Accelerator Center (SLAC) parity violation experiment E-158 uses a high intensity electron beam accelerated to either 45GeV or 48GeV in the SLAC Linac and requires a small energy spread, small off axis position motion, and low jitter. The purpose of our research was to better quantify the current values of energy, intensity, and position jitter as well as the relations between them and to further the understanding of the beam dynamics involved. Specifically, our method was to take data on a series of pulse lengths shorter than the experimental beam to gain information about the length dependence of the different beam parameters, effectively enabling us to create jitter, position, and energy profiles of the beam. Position was measured by beam position monitors (BPMs), intensity was measured by toroids, and energy was measured by a Synchrotron Light Monitor (SLM) as well as several energy BPMs. Data was collected using the SLAC Control Program (SCP) and analyzed using Matlab. Position jitter was found to, in general, increase linearly (10microns per 50ns) with pulse length. The peak to peak energy difference across each pulse is currently about 0.4% of the total energy, with the RMS energy jitter usually ranging from 0.013% to 0.10% for the different pulse lengths. Intensity jitter had no discernable correlation with pulse length. The slope of the linear relation between energy and intensity (beam loading relation) varied significantly with pulse length as well as with the method used to extract energy data. The position, intensity and energy profile data agree qualitatively with accepted theories and provide a more encompassing picture of the beam dynamics for E-158. The same is true, to a lesser extent, for the energy jitter and beam loading data, although some results here were unexpected.

  1. 49 CFR 173.158 - Nitric acid.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Nitric acid. 173.158 Section 173.158... Nitric acid. (a) Nitric acid exceeding 40 percent concentration may not be packaged with any other material. (b) Nitric acid in any concentration which does not contain sulfuric acid or hydrochloric acid as...

  2. Autofluorescence-free Live-cell Imaging Using Terbium Nanoparticles.

    Science.gov (United States)

    Cardoso Dos Santos, Marcelina; Goetz, Joan; Bartenlian, Hortense; Wong, Ka-Leung; Charbonniere, Loïc Joanny; Hildebrandt, Niko

    2018-02-20

    Fluorescent nanoparticles (NPs) have become irreplaceable tools for advanced cellular and sub-cellular imaging. While very bright NPs require excitation with UV or visible light, which can create strong autofluorescence of biological components, NIR-excitable NPs without autofluorescence issues exhibit much lower brightness. Here, we show the application of a new type of surface-photosensitized terbium NPs (Tb-NPs) for autofluorescence-free intracellular imaging in live HeLa cells. Combination of exceptionally high brightness, high photostability, and long photoluminecence (PL) lifetimes for highly efficient suppression of the short-lived autofluorescence, allowed for time-gated PL imaging of intracellular vesicles over 72 h without toxicity and at extremely low Tb-NP concentrations down to 12 pM. Detection of highly resolved long-lifetime (ms) PL decay curves from small (~10 µm2) areas within single cells within a few seconds emphasized the unprecedented photophysical properties of Tb-NPs for live-cell imaging that extend well beyond currently available nanometric imaging agents.

  3. Solar Thermochemical Hydrogen Production via Terbium Oxide Based Redox Reactions

    Directory of Open Access Journals (Sweden)

    Rahul Bhosale

    2016-01-01

    Full Text Available The computational thermodynamic modeling of the terbium oxide based two-step solar thermochemical water splitting (Tb-WS cycle is reported. The 1st step of the Tb-WS cycle involves thermal reduction of TbO2 into Tb and O2, whereas the 2nd step corresponds to the production of H2 through Tb oxidation by water splitting reaction. Equilibrium compositions associated with the thermal reduction and water splitting steps were determined via HSC simulations. Influence of oxygen partial pressure in the inert gas on thermal reduction of TbO2 and effect of water splitting temperature (TL on Gibbs free energy related to the H2 production step were examined in detail. The cycle (ηcycle and solar-to-fuel energy conversion (ηsolar-to-fuel efficiency of the Tb-WS cycle were determined by performing the second-law thermodynamic analysis. Results obtained indicate that ηcycle and ηsolar-to-fuel increase with the decrease in oxygen partial pressure in the inert flushing gas and thermal reduction temperature (TH. It was also realized that the recuperation of the heat released by the water splitting reactor and quench unit further enhances the solar reactor efficiency. At TH=2280 K, by applying 60% heat recuperation, maximum ηcycle of 39.0% and ηsolar-to-fuel of 47.1% for the Tb-WS cycle can be attained.

  4. Folate Receptor Targeted Alpha-Therapy Using Terbium-149

    CERN Document Server

    Müller, Cristina; Haller, Stephanie; Dorrer, Holger; Köster, Ulli; Johnston, Karl; Zhernosekov, Konstantin; Türler, Andreas; Schibli, Roger

    2014-01-01

    Terbium-149 is among the most interesting therapeutic nuclides for medical applications. It decays by emission of short-range α-particles (Eα = 3.967 MeV) with a half-life of 4.12 h. The goal of this study was to investigate the anticancer efficacy of a 149Tb-labeled DOTA-folate conjugate (cm09) using folate receptor (FR)-positive cancer cells in vitro and in tumor-bearing mice. 149Tb was produced at the ISOLDE facility at CERN. Radiolabeling of cm09 with purified 149Tb resulted in a specific activity of ~1.2 MBq/nmol. In vitro assays performed with 149Tb-cm09 revealed a reduced KB cell viability in a FR-specific and activity concentration-dependent manner. Tumor-bearing mice were injected with saline only (group A) or with 149Tb-cm09 (group B: 2.2 MBq; group C: 3.0 MBq). A significant tumor growth delay was found in treated animals resulting in an increased average survival time of mice which received 149Tb-cm09 (B: 30.5 d; C: 43 d) compared to untreated controls (A: 21 d). Analysis of blood parameters rev...

  5. Hardness and dielectric characteristics of flux grown terbium aluminate crystals

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, K.K.; Kotru, P.N. [Jammu Univ. (India). Dept. of Physics; Tandon, R.P. [National Physical Laboratory, New Delhi (India); Wanklyn, B.M. [Clarendon Laboratory, University of Oxford, Oxford (United Kingdom)

    1999-01-29

    Results of indentation induced Vickers hardness testing and dielectric studies conducted on flux-grown terbium aluminate crystals are presented. It is shown that the Vickers hardness value (H{sub v}) is independent of indentation time, but depends on the applied load. Applying the concept of Hays and Kendall, the load independent values are estimated for (110) and (001) planes. Differential behaviour in the crack formation of two different planes (110) and (001) is observed, while (001) plane develops Palmqvist cracks in the whole load range of 10-100 g, (110) plane shows a transition from Palmqvist to median cracks at 70 g. The fracture toughness, brittleness index and yield strength are determined for both the planes. The hardness anisotropy is reported. The dielectric constant, dielectric loss and conductivity are shown to be dependent on temperature and frequency of the applied a.c. field. The dielectric constant versus temperature shows a transition peak at 230 C, which remains independent of the frequency of the applied a.c. field in the range 1 kHz-13 MHz. (orig.) 36 refs.

  6. Thermoluminescence of cerium and terbium -doped calcium pyrophosphate

    Energy Technology Data Exchange (ETDEWEB)

    Roman L, J.; Cruz Z, E. [UNAM, Instituto de Ciencias Nucleares, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Lozano R, I. B.; Diaz G, J. A. I., E-mail: jesus.roman@nucleares.unam.mx [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria No. 694, 11500 Mexico D. F. (Mexico)

    2015-10-15

    The aim of this work is to report the thermoluminescence (Tl) response of Calcium Pyrophosphate phosphor doped with Cerium and Terbium impurities (Ca{sub 2}P{sub 2}O{sub 7}:Ce{sup 3+},Tb{sup 3+}). The phosphors were synthesized using the co-precipitation method and annealed at 900 degrees C by two hours for obtain the β phase. The intentional doping with Ce and Tb ions was 1 at.% and 0.1 at.%, whereas in the EDS results the concentration of impurities was 0.39 at.% and 0.05 at.%, respectively. The superficial morphology of phosphor is mainly composed by thin wafers of different size. All samples were exposed to gamma rays from {sup 60}Co in the Gammacell-200 irradiator. The Tl response of the phosphor was measured from Rt up to 350 degrees C and under nitrogen atmosphere in a Harshaw TLD 3500 reader. The glow curves of the Ca{sub 2}P{sub 2}O{sub 7}:Ce{sup 3+},Tb{sup 3+} powders showed a broad intense Tl peak centered at 165 degrees C and a shoulder at approximate 260 degrees C was observed. A linear Tl response in the range of absorbed dose of 0.2 to 10 Gy was obtained. Tl glow curves were analyzed using the initial rise (IR)and computerized glow curve deconvolution methods to evaluate the kinetics parameters such as activation energy (E), frequency factor (s) and kinetic order (b). (Author)

  7. Stream Habitat Reach Summary - NCWAP [ds158

    Data.gov (United States)

    California Department of Resources — The Stream Habitat - NCWAP - Reach Summary [ds158] shapefile contains in-stream habitat survey data summarized to the stream reach level. It is a derivative of the...

  8. Dicty_cDB: VHF158 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VH (Link to library) VHF158 (Link to dictyBase) - - - - VHF158P (Link to Original site) VHF158F 608 VHF...158Z 693 VHF158P 1281 - - Show VHF158 Library VH (Link to library) Clone ID VHF158 (Link... to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VH/VHF...1-C/VHF158Q.Seq.d/ Representative seq. ID VHF158P (Link to... Original site) Representative DNA sequence >VHF158 (VHF158Q) /CSM/VH/VHF1-C/VHF158Q.Seq.d/ AACTCTCGAGTGCAAA

  9. Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence.

    Science.gov (United States)

    Walter, Edward R H; Williams, J A Gareth; Parker, David

    2017-12-14

    In a macrocyclic terbium complex incorporating a biaryl sensitiser, the observed variation of emission lifetime is shown to be determined by the solubility of oxygen in the solvent system and the relative energy of the chromophore excited state, rather than any dependence on solvent viscosity.

  10. Dicty_cDB: SLB158 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLB158 (Link to dictyBase) - - - Contig-U16455-1 SLB158Z (Link... to Original site) - - SLB158Z 721 - - - - Show SLB158 Library SL (Link to library) Clone ID SLB158 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLB1-C/SLB158Q.Seq.d/ Representative seq. ID SLB15...8Z (Link to Original site) Representative DNA sequence >SLB158 (SLB158Q) /CSM/SL/SLB1-C/SLB158Q.Seq.d/ XXXXX... SLE193 (SLE193Q) /CSM/SL/SLE1-D/SLE193Q.Seq.d/ 1407 0.0 SLB795 (SLB795Q) /CSM/SL/SLB7-D/SLB795Q.Seq.d/ 1407 0.0 SLB249 (SLB

  11. Arginine-responsive terbium luminescent hybrid sensors triggered by two crown ether carboxylic acids

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Lasheng [Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); Tang, Ke; Ding, Xiaoping [School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); Wang, Qianming, E-mail: qmwang@scnu.edu.cn [Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); Zhou, Zhan; Xiao, Rui [School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China)

    2013-12-01

    Crown ether carboxylic acids constitute main building blocks for the synthesis of terbium containing covalent cross-linked luminescent materials. Both the complexes and the hybrid nanomaterials could exhibit remarkable green emissions in pure water. More importantly, they were found to have a profound effect on the luminescence responses to arginine compared with glutamic acid, histidine, tryptophan, threonine, tyrosine and phenylalanine in aqueous environment. The present study provided the possibility of using a host–guest mechanism as a way of signal transduction based on lanthanide supramolecular hybrid materials. - Highlights: • Crown ether carboxylic acids were found to sensitize terbium ions among a group of ethers. • The complexes and silica hybrid materials were both prepared and characterized. • They could exhibit remarkable green emissions in pure water.

  12. Comparative analysis of conjugated alkynyl chromophore-triazacyclononane ligands for sensitized emission of europium and terbium.

    Science.gov (United States)

    Soulié, Marine; Latzko, Frédéric; Bourrier, Emmanuel; Placide, Virginie; Butler, Stephen J; Pal, Robert; Walton, James W; Baldeck, Patrice L; Le Guennic, Boris; Andraud, Chantal; Zwier, Jurriaan M; Lamarque, Laurent; Parker, David; Maury, Olivier

    2014-07-07

    A series of europium and terbium complexes based on a functionalized triazacyclononane carboxylate or phosphinate macrocyclic ligand is described. The influence of the anionic group, that is, carboxylate, methylphosphinate, or phenylphosphinate, on the photophysical properties was studied and rationalized on the basis of DFT calculated structures. The nature, number, and position of electron-donating or electron-withdrawing aryl substituents were varied systematically within the same phenylethynyl scaffold in order to optimize the brightness of the corresponding europium complexes and investigate their two-photon absorption properties. Finally, the europium complexes were examined in cell-imaging applications, and selected terbium complexes were studied as potential oxygen sensors. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. 40 CFR 158.45 - Waivers.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES General Provisions § 158.45 Waivers. (a) The data requirements specified in this part... of the risks or benefits of the product. The Agency will waive data requirements it finds are...

  14. Spectrofluorimetric Determination of Human Serum Albumin Using Terbium-Danofloxacin Probe

    OpenAIRE

    Ramezani, Amir M.; Manzoori, Jamshid L.; Amjadi, Mohammad; Jouyban, Abolghasem

    2012-01-01

    A spectrofluorimetric method is proposed for the determination of human serum albumin (HSA) and bovine serum albumin (BSA) using terbium-danofloxacin (Tb3+-Dano) as a fluorescent probe. These proteins remarkably enhance the fluorescence intensity of the Tb3+-Dano complex at 545 nm, and the enhanced fluorescence intensity of Tb3+-Dano is proportional to the concentration of proteins (HSA and BSA). Optimum conditions for the determination of HSA were investigated and found that the maximum resp...

  15. Genetically Encoded FRET-Sensor Based on Terbium Chelate and Red Fluorescent Protein for Detection of Caspase-3 Activity

    Directory of Open Access Journals (Sweden)

    Alexander S. Goryashchenko

    2015-07-01

    Full Text Available This article describes the genetically encoded caspase-3 FRET-sensor based on the terbium-binding peptide, cleavable linker with caspase-3 recognition site, and red fluorescent protein TagRFP. The engineered construction performs two induction-resonance energy transfer processes: from tryptophan of the terbium-binding peptide to Tb3+ and from sensitized Tb3+ to acceptor—the chromophore of TagRFP. Long-lived terbium-sensitized emission (microseconds, pulse excitation source, and time-resolved detection were utilized to eliminate directly excited TagRFP fluorescence and background cellular autofluorescence, which lasts a fraction of nanosecond, and thus to improve sensitivity of analyses. Furthermore the technique facilitates selective detection of fluorescence, induced by uncleaved acceptor emission. For the first time it was shown that fluorescence resonance energy transfer between sensitized terbium and TagRFP in the engineered construction can be studied via detection of microsecond TagRFP fluorescence intensities. The lifetime and distance distribution between donor and acceptor were calculated using molecular dynamics simulation. Using this data, quantum yield of terbium ions with binding peptide was estimated.

  16. 40 CFR 158.2010 - Biochemical pesticides data requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Biochemical pesticides data...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2010 Biochemical pesticides... required to support registration of biochemical pesticides. Sections 158.2080 through 158.2084 identify the...

  17. 18 CFR 158.12 - Qualifications of accountants.

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    2010-04-01

    ... accountants. 158.12 Section 158.12 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Proposed Remedies § 158.12 Qualifications of accountants. The Commission will recognize only independent certified public accountants, or independent licensed public accountants who were licensed on or before...

  18. 34 CFR 300.158-300.159 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false 300.158-300.159 Section 300.158-300.159 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Additional Eligibility Requirements §§ 300.158-300.159 ...

  19. 27 CFR 25.158 - Tax computation for bottled beer.

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    2010-04-01

    ... bottled beer. 25.158 Section 25.158 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Tax on Beer Determination of Tax § 25.158 Tax computation for bottled beer. Barrel equivalents for various case sizes are as follows: (a) For U.S. measure...

  20. 7 CFR 3550.158 - Active military duty.

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    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Active military duty. 3550.158 Section 3550.158... AGRICULTURE DIRECT SINGLE FAMILY HOUSING LOANS AND GRANTS Regular Servicing § 3550.158 Active military duty...-time active military duty after a loan is closed not exceed six percent. Active military duty does not...

  1. Green light emission in aluminum oxide powders doped with different terbium concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Mariscal B, L; Falcony, C. [IPN, Centro de Investigacion y de Estudios Avanzados, 07360 Ciudad de Mexico (Mexico); Carmona T, S.; Murrieta, H.; Sanchez A, M. A. [UNAM, Instituto de Fisica, 04510 Ciudad de Mexico (Mexico); Vazquez A, R. [IPN, Escuela Superior de Computo, 07738 Ciudad de Mexico (Mexico); Garcia R, C. M., E-mail: mariscal2005@gmail.com [UNAM, Facultad de Ciencias, 04510 Ciudad de Mexico (Mexico)

    2016-11-01

    Different emission intensities presented in aluminum oxide phosphors corresponding to different concentrations of doping performed with terbium are analyzed. The phosphors were synthesized by the evaporation technique and were characterized by photo and cathodoluminescence, X-ray diffraction and EDS techniques for different incorporation percentages of terbium as dopant; they show characteristic transitions in 494, 543, 587 and 622 nm, corresponding to {sup 5}D{sub 4} → {sup 7}F{sub 6}, {sup 5}D{sub 4} → {sup 7}F{sub 5}, {sup 5}D{sub 4} → {sup 7}F{sub 4} and {sup 5}D{sub 4} → {sup 7}F{sub 3}, respectively when they are excited with λ{sub exc} = 380 nm wavelength at room temperature. The results of X-ray diffraction show the presence of α-Al{sub 2}O{sub 3} phases with peaks located at 2θ = 25.78, 35.34, 37.96, 43.56, 45.8, 52.74, 57.7, 61.5, 66.74, 68.44, 77.12 and 80.94, and the δ-Al{sub 2}O-3 phase 2θ = 32.82, 45.8, 61.36 and 66.74. These compounds were heat treated for two hours at 1100 degrees Celsius. EDS analyzes indicate that these compounds have close to 60% oxygen around of 40% aluminum in the presence of terbium as dopant which indicates a stoichiometry close to the expected one for alumina. (Author)

  2. Graphene quantum dots-terbium ions as novel sensitive and selective time-resolved luminescent probes.

    Science.gov (United States)

    Llorent-Martínez, Eulogio J; Durán, Gema M; Ríos, Ángel; Ruiz-Medina, Antonio

    2018-01-01

    We propose an alternative approach for the development of analytical methods based on terbium-sensitized luminescence (TSL). TSL is based on the complexation between Tb(III) ions and fluorescent organic compounds that have appropriate functional groups to complex with Tb(III). We report the use of graphene quantum dot (GQDs) nanoparticles to improve the sensitivity and selectivity of TSL detection. GQDs can react with terbium ions through the carboxylic groups present in their structure. These Tb(III)-GQD complexes, formed in situ in aqueous solution, can be used as time-resolved luminescent probes. Ascorbic acid was selected as a target analyte to demonstrate the suitability of the proposed method. The selectivity of the TSL method was highly improved for most of the interferences tested. Under the optimum conditions [Tb(III) concentration 5 × 10-4 mol L-1, GQD concentration 4 mg L-1], a minimum 100% increase in selectivity was observed for several vitamins and common cations that may be present in the samples to be analyzed. In addition, the analytical signal showed a 30% enhancement with the use of GQDs compared with the use of merely Tb(III) ions, with a detection limit of 0.12 μg mL-1. The repeatability and intermediate precision were lower than 3% and 5%, respectively. From the results obtained, the implementation of GQDs in TSL can lead to the development of novel time-resolved luminescent probes with high analytical potential. Graphical abstract Quenching of Tb(III)-graphene quantum dot (GQD) luminescence by ascorbic acid (AA). TBL terbium-sensitized luminescence.

  3. Fluorescence study of some terbium-oligopeptide complexes in methanolic solution.

    Science.gov (United States)

    Rabouan, S; Delage, J; Durand, W; Prognon, P; Barthes, D

    2000-04-03

    This study concerned the use of lanthanide chelates to detect glycyl-leucyl-phenylalanine (GLF) and its homologues. Spectroscopic analysis of peptides without or with terbium complexation revealed the formation of (LF)(3)(Tb)(2), (GF)(3)(Tb)(2), (GLF)(3)(Tb)(2) and (FL)(4)Tb, (FG)(4)Tb complexes with high stability constants in methanolic solutions (pK(d)>13). Lanthanide chelate emission displayed a large Stokes shift (>270 nm), which allowed Tb chelates of GLF and its derivatives to be used for detection purposes. However, this preliminary study indicated some important limitations associated with lanthanide chelation, such as high methanolic content.

  4. Electromagnetic properties of terbium gallium garnet at millikelvin temperatures and low photon energy

    Science.gov (United States)

    Kostylev, Nikita; Goryachev, Maxim; Bushev, Pavel; Tobar, Michael E.

    2017-07-01

    Electromagnetic properties of single crystal terbium gallium garnet are characterised from room down to millikelvin temperatures using the whispering gallery mode method. Microwave spectroscopy is performed at low powers equivalent to a few photons in energy and conducted as functions of the magnetic field and temperature. A phase transition is detected close to the temperature of 3.5 K. This is observed for multiple whispering gallery modes causing an abrupt negative frequency shift and a change in transmission due to extra losses in the new phase caused by a change in complex magnetic susceptibility.

  5. Nuclear excitation functions from 40 to 200 MeV proton irradiation of terbium

    Energy Technology Data Exchange (ETDEWEB)

    Engle, Jonathan W., E-mail: jwengle@lanl.gov; Mashnik, Stepan G.; Parker, Lauren A.; Jackman, Kevin R.; Bitteker, Leo J.; Ullmann, John L.; Gulley, Mark S.; Pillai, Chandra; John, Kevin D.; Birnbaum, Eva R.; Nortier, Francois M.

    2016-01-01

    Nuclear formation cross sections are reported for 26 radionuclides, measured with 40–200 MeV proton irradiations of terbium foils. These data provide the basis for the production of medically relevant radionuclides (e.g., {sup 152}Tb, {sup 155}Tb, {sup 155}Eu, and {sup 156}Eu) and {sup 153}Gd, a potential source used in ongoing efforts to characterize stellar nucleosynthesis routes. Computational predictions from the ALICE2011, CEM03.03, Bertini, and INCL + ABLA codes are compared with newly measured data to contribute to the ongoing process of code development, and yields are calculated for selected radionuclides using measured data.

  6. Micelle-enhanced and terbium-sensitized spectrofluorimetric determination of gatifloxacin and its interaction mechanism

    Science.gov (United States)

    Guo, Changchuan; Wang, Lei; Hou, Zhun; Jiang, Wei; Sang, Lihong

    2009-05-01

    A terbium-sensitized spectrofluorimetric method using an anionic surfactant, sodium dodecyl benzene sulfonate (SDBS), was developed for the determination of gatifloxacin (GFLX). A coordination complex system of GFLX-Tb 3+-SDBS was studied. It was found that SDBS significantly enhanced the fluorescence intensity of the complex (about 11-fold). Optimal experimental conditions were determined as follows: excitation and emission wavelengths of 331 and 547 nm, pH 7.0, 2.0 × 10 -4 mol l -1 terbium (III), and 2.0 × 10 -4 mol l -1 SDBS. The enhanced fluorescence intensity of the system (Δ If) showed a good linear relationship with the concentration of GFLX over the range of 5.0 × 10 -10 to 5.0 × 10 -8 mol l -1 with a correlation coefficient of 0.9996. The detection limit (3 σ) was determined as 6.0 × 10 -11 mol l -1. This method has been successfully applied to the determination of GFLX in pharmaceuticals and human urine/serum samples. Compared with most of other methods reported, the rapid and simple procedure proposed in the text offers higher sensitivity, wider linear range, and better stability. The interaction mechanism of the system is also studied by the research of ultraviolet absorption spectra, surface tension, solution polarity and fluorescence polarization.

  7. Circularly Polarized Luminescence in Enantiopure Europium and Terbium Complexes with Modular, All-Oxygen Donor Ligands

    Science.gov (United States)

    Seitz, Michael; Do, King; Ingram, Andrew J.; Moore, Evan G.; Muller, Gilles; Raymond, Kenneth N.

    2009-01-01

    Abstract: Circulaly polarized luminescence from terbium(III) complexed and excited by chiral antenna ligands gives strong emission The modular synthesis of three new octadentate, enantiopure ligands are reported - one with the bidentate chelating unit 2-hydroxyisophthalamide (IAM) and two with 1-hydroxy-2-pyridinone (1,2-HOPO) units. A new design principle is introduced for the chiral, non-racemic hexamines which constitute the central backbones for the presented class of ligands. The terbium(III) complex of the IAM ligand, as well as the europium(III) complexes of the 1,2-HOPO ligands are synthesized and characterized by various techniques (NMR, UV, CD, luminescence spectroscopy). All species exhibit excellent stability and moderate to high luminescence efficiency (quantum yields ΦEu = 0.05–0.08 and ΦTb = 0.30–0.57) in aqueous solution at physiological pH. Special focus is put onto the properties of the complexes in regard to circularly polarized luminescence (CPL). The maximum luminescence dissymmetry factors (glum) in aqueous solution are high with |glum|max = 0.08 – 0.40. Together with the very favorable general properties (good stability, high quantum yields, long lifetimes), the presented lanthanide complexes can be considered as good candidates for analytical probes based on CPL in biologically relevant environments. PMID:19639983

  8. Luminescent method of determination of composition of europium and terbium complexes in solution by change of intensity ratio of luminescence bands

    Energy Technology Data Exchange (ETDEWEB)

    Bel' tyukova, S.V.; Nazarenko, N.A.; Poluehktov, N.S.

    1982-03-01

    The complexes of europium and terbium with phenanthroline, ethylenediaminetetraacetate, nitrilotriacetate, some acids-phenol derivatives and ..beta..-diketones series have been used as an example to demonstrate that the value of the ratio of intensities on the two bands of europium(terbium) luminescence spectra - the one corresponding to the hypersensitive'' transition and the other, to the magnetic dipole one - can be used for determination of the complexes composition in solutions.

  9. Gpr158 mediates osteocalcin's regulation of cognition.

    Science.gov (United States)

    Khrimian, Lori; Obri, Arnaud; Ramos-Brossier, Mariana; Rousseaud, Audrey; Moriceau, Stéphanie; Nicot, Anne-Sophie; Mera, Paula; Kosmidis, Stylianos; Karnavas, Theodoros; Saudou, Frederic; Gao, Xiao-Bing; Oury, Franck; Kandel, Eric; Karsenty, Gerard

    2017-10-02

    That osteocalcin (OCN) is necessary for hippocampal-dependent memory and to prevent anxiety-like behaviors raises novel questions. One question is to determine whether OCN is also sufficient to improve these behaviors in wild-type mice, when circulating levels of OCN decline as they do with age. Here we show that the presence of OCN is necessary for the beneficial influence of plasma from young mice when injected into older mice on memory and that peripheral delivery of OCN is sufficient to improve memory and decrease anxiety-like behaviors in 16-mo-old mice. A second question is to identify a receptor transducing OCN signal in neurons. Genetic, electrophysiological, molecular, and behavioral assays identify Gpr158, an orphan G protein-coupled receptor expressed in neurons of the CA3 region of the hippocampus, as transducing OCN's regulation of hippocampal-dependent memory in part through inositol 1,4,5-trisphosphate and brain-derived neurotrophic factor. These results indicate that exogenous OCN can improve hippocampal-dependent memory in mice and identify molecular tools to harness this pathway for therapeutic purposes. © 2017 Khrimian et al.

  10. 40 CFR 158.320 - Product identity and composition.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Product identity and composition. 158... PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.320 Product identity and composition. Information on the composition of the pesticide product must be furnished. The information required by...

  11. 7 CFR 457.158 - Apple crop insurance provisions.

    Science.gov (United States)

    2010-01-01

    .... Optional Coverage for Fresh Fruit Quality Adjustment (a) In the event of a conflict between the Apple Crop... 7 Agriculture 6 2010-01-01 2010-01-01 false Apple crop insurance provisions. 457.158 Section 457... CORPORATION, DEPARTMENT OF AGRICULTURE COMMON CROP INSURANCE REGULATIONS § 457.158 Apple crop insurance...

  12. 7 CFR 15.8 - Procedure for effecting compliance.

    Science.gov (United States)

    2010-01-01

    ...) Other means authorized by law. No action to effect compliance by any other means authorized by law shall... 7 Agriculture 1 2010-01-01 2010-01-01 false Procedure for effecting compliance. 15.8 Section 15.8 Agriculture Office of the Secretary of Agriculture NONDISCRIMINATION Nondiscrimination in Federally-Assisted...

  13. 20 CFR 655.158 - Duration of positive recruitment.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Duration of positive recruitment. 655.158 Section 655.158 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY... recruitment. Except as otherwise noted, the obligation to engage in positive recruitment described in §§ 655...

  14. 33 CFR 157.158 - COW operations: Changed characteristics.

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    2010-07-01

    ... characteristics. 157.158 Section 157.158 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...: Changed characteristics. The COW system may be operated with characteristics that do not meet those... changed characteristics; (b) The changed characteristics used to pass the inspections under § 157.140 are...

  15. 40 CFR 158.330 - Description of production process.

    Science.gov (United States)

    2010-07-01

    ... characterization of the process (e.g., whether it is a batch or continuous process). (3) A flow chart of the... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Description of production process. 158... PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.330 Description of production process. If...

  16. Thermo-transferred thermoluminescence (TTTl) in potassium-yttrium double fluoride doped with terbium

    Energy Technology Data Exchange (ETDEWEB)

    Gallegos, A.; Rivera, T.; Diaz G, J. A. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Legaria 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico); Azorin, J. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, San Rafael Atlixco No. 186, Col. Vicentina, 09340 Mexico D. F. (Mexico); Azorin, J. C. [Universidad de Guanajuato, Division de Ciencias e Ingenierias-Campus Leon, Lomas del Bosque No. 103, Col. Lomas del Campestre, 37000 Leon, Guanajuato (Mexico); Licona, R.; Rivas, F.; Hernandez C, G. [Benemerita Universidad Autonoma de Puebla, Facultad de Ciencias Quimicas, 14 Sur y San Claudio, Ciudad Universitaria, Puebla de Zaragoza, Puebla (Mexico); Khaidukov, N. [Institute of General and Inorganic Chemistry, Lenin SK 11 Prospect 31, Moscow 117907 (Russian Federation)

    2011-02-15

    This paper presents results of studying the thermo-transferred thermoluminescence (TTTl) phenomenon in potassium-yttrium double fluoride doped with terbium (K{sub 2}YF{sub 5:}Tb) at different impurity concentrations (0.8%, 0.95% and 0.99%). Previously to study the TTTl phenomenon, structural characterization and chemical composition of the materials were determined. The structural studies were conducted using a scanning electron microscope; meanwhile, chemical composition was analyzed using energy dispersive X-ray spectroscopy. Thermoluminescence kinetics was studied irradiating the samples with {sup 137}Cs gamma rays as well as with {sup 90}Sr/{sup 90}Y beta rays, analyzing the glow curves by the deconvolution method for obtaining the kinetic parameters. (Author)

  17. The influence of pressure on the photoluminescence properties of a terbium-adipate framework

    Science.gov (United States)

    Spencer, Elinor C.; Zhao, Jing; Ross, Nancy L.; Andrews, Michael B.; Surbella, Robert G.; Cahill, Christopher L.

    2013-06-01

    The influence of pressure (over the 0-4.7 GPa range) on the photoluminescence emissions and crystal structure of the known 3D terbium-adipate metal-organic framework material Tb-GWMOF6 has been evaluated by high-pressure single-crystal X-ray diffraction and spectroscopic techniques. The results from this study show that this complex lanthanide framework structure undergoes three phase transitions within the 0-4 GPa pressure range that involve alterations in the number of symmetry independent Tb3+ ion sites within the crystal lattice. These pressure induced modifications to the structure of Tb-GWMOF6 lead to pronounced changes in the profiles of the 5D4→7F5 emission spectra of this complex.

  18. Terbium Radionuclides for Theranostics Applications: A Focus On MEDICIS-PROMED

    Science.gov (United States)

    Cavaier, R. Formento; Haddad, F.; Sounalet, T.; Stora, T.; Zahi, I.

    A new facility, named CERN-MEDICIS, is under construction at CERN to produce radionuclides for medical applications. In parallel, the MEDICIS-PROMED, a Marie Sklodowska-Curie innovative training network of the Horizon 2020 European Commission's program, is being coordinated by CERN to train young scientists on the production and use of innovative radionuclides and develop a network of experts within Europe. One program within MEDICIS-PROMED is to determine the feasibility of producing innovative radioisotopes for theranostics using a commercial middle-sized high-current cyclotron and the mass separation technology developed at CERN-MEDICIS. This will allow the production of high specific activity radioisotopes not achievable with the common post-processing by chemical separation. Radioisotopes of scandium, copper, arsenic and terbium have been identified. Preliminary studies of activation yield and irradiation parameters optimization for the production of Tb-149 will be described.

  19. Dielectric and conducting behavior of gadolinium-terbium fumarate heptahydrate crystals

    Science.gov (United States)

    Shah, M. D.; Want, B.

    2015-07-01

    Gadolinium-terbium fumarate heptahydrate crystals were grown in silica gel by using single gel diffusion technique. The crystals were characterized by different physico-chemical techniques of characterization. Powder X-ray diffraction results showed that the grown material is purely crystalline in nature. Elemental analyses suggested the chemical formula of the compound to be Gd Tb (C4H2O4)3ṡ7H2O. Energy dispersive X-ray analysis confirmed the presence of Gd and Tb in the title compound. The dielectric and conductivity studies of the grown compound were carried as function of frequency of applied field and the temperature. The grown material showed a dielectric anomaly which was correlated with its thermal behavior. The ac conductivity of the material showed Jonscher's power law behavior: σ(ω)=σo+Aωs, with a temperature-dependent power exponent s(<1). The conductivity was found to be a function of temperature and frequency.

  20. Highly sensitive detection of dipicolinic acid with a water-dispersible terbium-metal organic framework.

    Science.gov (United States)

    Bhardwaj, Neha; Bhardwaj, Sanjeev; Mehta, Jyotsana; Kim, Ki-Hyun; Deep, Akash

    2016-12-15

    The sensitive detection of dipicolinic acid (DPA) is strongly associated with the sensing of bacterial organisms in food and many types of environmental samples. To date, the demand for a sensitive detection method for bacterial toxicity has increased remarkably. Herein, we investigated the DPA detection potential of a water-dispersible terbium-metal organic framework (Tb-MOF) based on the fluorescence quenching mechanism. The Tb-MOF showed a highly sensitive ability to detect DPA at a limit of detection of 0.04nM (linear range of detection: 1nM to 5µM) and also offered enhanced selectivity from other commonly associated organic molecules. The present study provides a basis for the application of Tb-MOF for direct, convenient, highly sensitive, and specific detection of DPA in the actual samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. A New Bis(phthalocyaninato) Terbium Single-Ion Magnet with an Overall Excellent Magnetic Performance.

    Science.gov (United States)

    Chen, Yuxiang; Ma, Fang; Chen, Xiaoxiang; Dong, Bowei; Wang, Kang; Jiang, Shangda; Wang, Chiming; Chen, Xin; Qi, Dongdong; Sun, Haoling; Wang, Bingwu; Gao, Song; Jiang, Jianzhuang

    2017-11-20

    Bulky and strong electron-donating dibutylamino groups were incorporated onto the peripheral positions of one of the two phthalocyanine ligands in the bis(phthalocyaninato) terbium complex, resulting in the isolation of heteroleptic double-decker (Pc)Tb{Pc[N(C4H9)2]8} {Pc = phthalocyaninate; Pc[N(C4H9)2]8 = 2,3,9,10,16,17,23,24-octakis(dibutylamino)phthalocyaninate} with the nature of an unsymmetrical molecular structure, a square-antiprismatic coordination geometry, an intensified coordination field strength, and the presence of organic radical-f interaction. As a total result of all these factors, this sandwich-type tetrapyrrole lanthanide single-ion magnet (SIM) exhibits an overall enhanced magnetic performance including a high blocking temperature (TB) of 30 K and large effective spin-reversal energy barrier of Ueff = 939 K, rendering it the best sandwich-type tetrapyrrole lanthanide SIM reported thus far.

  2. Ultralarge magneto-optic rotations and rotary dispersion in terbium gallium garnet single crystal.

    Science.gov (United States)

    Shaheen, Amrozia; Majeed, Hassaan; Anwar, Muhammad Sabieh

    2015-06-10

    We report systematically acquired data on the Verdet constant of terbium gallium garnet for wavelengths ranging from visible to near-infrared (405-830 nm) regime. Our experimental method of Stokes polarimetry is based on the Fourier decomposition of the received light intensity and allows unambiguous determination of both the Faraday rotation and the ellipticity of the emergent light. Temperature-dependent investigations in the range of 8-300 K extend earlier reports and verify the Verdet's constant direct dependence on the magnetization, whose first-order approximation is simply a manifestation of the Curie's law. Further, a least-squares fitting of the experimental data correlates well with theoretical predictions. At a wavelength of 405 nm and temperature of 8 K, the rotation is approximately 500°.

  3. Terbium fluorescence as a sensitive, inexpensive probe for UV-induced damage in nucleic acids

    Energy Technology Data Exchange (ETDEWEB)

    El-Yazbi, Amira F.; Loppnow, Glen R., E-mail: glen.loppnow@ualberta.ca

    2013-07-05

    Graphical abstract: -- Highlights: •Simple, inexpensive, mix-and-read assay for positive detection of DNA damage. •Recognition of undamaged DNA via hybridization to a hairpin probe. •Terbium(III) fluorescence reports the amount of damage by binding to ssDNA. •Tb/hairpin is a highly selective and sensitive fluorescent probe for DNA damage. -- Abstract: Much effort has been focused on developing methods for detecting damaged nucleic acids. However, almost all of the proposed methods consist of multi-step procedures, are limited, require expensive instruments, or suffer from a high level of interferences. In this paper, we present a novel simple, inexpensive, mix-and-read assay that is generally applicable to nucleic acid damage and uses the enhanced luminescence due to energy transfer from nucleic acids to terbium(III) (Tb{sup 3+}). Single-stranded oligonucleotides greatly enhance the Tb{sup 3+} emission, but duplex DNA does not. With the use of a DNA hairpin probe complementary to the oligonucleotide of interest, the Tb{sup 3+}/hairpin probe is applied to detect ultraviolet (UV)-induced DNA damage. The hairpin probe hybridizes only with the undamaged DNA. However, the damaged DNA remains single-stranded and enhances the intrinsic fluorescence of Tb{sup 3+}, producing a detectable signal directly proportional to the amount of DNA damage. This allows the Tb{sup 3+}/hairpin probe to be used for sensitive quantification of UV-induced DNA damage. The Tb{sup 3+}/hairpin probe showed superior selectivity to DNA damage compared to conventional molecular beacons probes (MBs) and its sensitivity is more than 2.5 times higher than MBs with a limit of detection of 4.36 ± 1.2 nM. In addition, this probe is easier to synthesize and more than eight times cheaper than MBs, which makes its use recommended for high-throughput, quantitative analysis of DNA damage.

  4. Fine- and hyperfine structure investigations of even configuration system of atomic terbium

    Science.gov (United States)

    Stefanska, D.; Elantkowska, M.; Ruczkowski, J.; Furmann, B.

    2017-03-01

    In this work a parametric study of the fine structure (fs) and the hyperfine structure (hfs) for the even-parity configurations of atomic terbium (Tb I) is presented, based in considerable part on the new experimental results. Measurements on 134 spectral lines were performed by laser induced fluorescence (LIF) in a hollow cathode discharge lamp; on this basis, the hyperfine structure constants A and B were determined for 52 even-parity levels belonging to the configurations 4f85d6s2, 4f85d26s or 4f96s6p; in all the cases those levels were involved in the transitions investigated as the lower levels. For 40 levels the hfs was examined for the first time, and for the remaining 12 levels the new measurements supplement our earlier results. As a by-product, also preliminary values of the hfs constants for 84 odd-parity levels were determined (the investigations of the odd-parity levels system in the terbium atom are still in progress). This huge amount of new experimental data, supplemented by our earlier published results, were considered for the fine and hyperfine structure analysis. A multi-configuration fit of 7 configurations was performed, taking into account second-order of perturbation theory, including the effects of closed shell-open shell excitations. Predicted values of the level energies, as well as of magnetic dipole and electric quadrupole hyperfine structure constants A and B, are quoted in cases when no experimental values are available. By combining our experimental data with our own semi-empirical procedure it was possible to identify correctly the lower and upper level of the line 544.1440 nm measured by Childs with the use of the atomic-beam laser-rf double-resonance technique (Childs, J Opt Soc Am B 9;1992:191-6).

  5. Structural and optical characterization of terbium doped ZnGa2O4 thin films deposited by RF magnetron sputtering

    Science.gov (United States)

    Somasundaram, K.; Girija, K. G.; Sudarsan, V.; Selvin, P. Christopher; Vatsa, R. K.

    2016-05-01

    Tb3+ doped ZnGa2O4 nanophosphor (21 nm) has been synthesized via low temperature polyol route and subsequently thin films of the same were deposited on glass and ITO substrates by RF magnetron sputtering. The films were characterized by X-ray Diffraction and luminescence measurements. The XRD pattern showed that Tb3+ doped ZnGa2O4 nanophosphor has a cubic spinel phase. Luminescence behavior of the nanophosphor and as deposited sputtered film was investigated. The PL emission spectra of nanophosphor gave a broad ZnGa2O4 host emission band along with a strong terbium emission and the thin films showed only broad host emission band and there was no terbium ion emission.

  6. Determination of fluoxetine in pharmaceutical and biological samples based on the silver nanoparticle enhanced fluorescence of fluoxetine-terbium complex.

    Science.gov (United States)

    Lotfi, Ali; Manzoori, Jamshid L

    2016-11-01

    In this study, a simple and sensitive spectrofluorimetric method is presented for the determination of fluoxetine based on the enhancing effect of silver nanoparticles (AgNPs) on the terbium-fluoxetine fluorescence emission. The AgNPs were prepared by a simple reduction method and characterized by UV-Vis spectroscopy and transmission electron microscopy. It was indicated that these AgNPs have a remarkable amplifying effect on the terbium-sensitized fluorescence of fluoxetine. The effects of various parameters such as AgNP and Tb(3+) concentration and the pH of the media were investigated. Under obtained optimal conditions, the fluorescence intensity of the terbium-fluoxetine-AgNP system was enhanced linearly by increasing the concentration of fluoxetine in the range of 0.008 to 19 mg/L. The limit of detection (b + 3s) was 8.3 × 10(-4) mg/L. The interference effects of common species found in real samples were also studied. The method had good linearity, recovery, reproducibility and sensitivity, and was satisfactorily applied for the determination of fluoxetine in tablet formulations, human urine and plasma samples. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  7. Neutron Diffraction and Electrical Transport Studies on Magnetic Transition in Terbium at High Pressures and Low Temperatures

    Science.gov (United States)

    Thomas, Sarah; Montgomery, Jeffrey; Tsoi, Georgiy; Vohra, Yogesh; Weir, Samuel; Tulk, Christopher; Moreira Dos Santos, Antonio

    2013-06-01

    Neutron diffraction and electrical transport measurements have been carried out on the heavy rare earth metal terbium at high pressures and low temperatures in order to elucidate its transition from a helical antiferromagnetic to a ferromagnetic ordered phase as a function of pressure. The electrical resistance measurements using designer diamonds show a change in slope as the temperature is lowered through the ferromagnetic Curie temperature. The temperature of the ferromagnetic transition decreases at a rate of -16.7 K/GPa till 3.6 GPa, where terbium undergoes a structural transition from hexagonal close packed (hcp) to an α-Sm phase. Above this pressure, the electrical resistance measurements no longer exhibit a change in slope. In order to confirm the change in magnetic phase suggested by the electrical resistance measurements, neutron diffraction measurements were conducted at the SNAP beamline at the Oak Ridge National Laboratory. Measurements were made at pressures to 5.3 GPa and temperatures as low as 90 K. An abrupt increase in peak intensity in the neutron diffraction spectra signaled the onset of magnetic order below the Curie temperature. A magnetic phase diagram of rare earth metal terbium will be presented to 5.3 GPa and 90 K based on these studies.

  8. 40 CFR 158.2084 - Experimental use permit biochemical pesticides nontarget organisms and environmental fate data...

    Science.gov (United States)

    2010-07-01

    ... pesticides nontarget organisms and environmental fate data requirements table. 158.2084 Section 158.2084 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2084 Experimental use permit biochemical pesticides...

  9. Study of Silver Nanoparticles Sensitized Fluorescence and Second-Order Scattering of Terbium(III-Pefloxacin Mesylate Complex and Determination of Pefloxacin Mesylate

    Directory of Open Access Journals (Sweden)

    Aiyun Li

    2014-01-01

    Full Text Available α-Keto acid of pefloxacin mesylate (PFLX can form the complex with Terbium(III. The intramolecular energy from PFLX to Terbium(III ion takes place when excited, and thus Terbium(III excited state is formed and then emits the characteristic fluorescence of Terbium(III, locating at 490, 545, 580, and 620 nm. The second-order scattering (SOS peak at 545 nm also appears for the complex with the exciting wavelength of 273 nm. When the silver nanoparticles are added to the system, the luminescence intensity at 545 nm greatly increased. So, with the adding of nanoparticles to the Terbium(III-PFLX complex, not only is the intramolecular energy promoted but also the SOS intensity is enhanced. The experimental results show that it is the silver nanoparticles with certain size and certain concentration which can greatly enhance the fluorescence-SOS intensity, and the relative intensity at 545 nm is proportional to the amount of PFLX. Based on this phenomenon, a novel method for the determination of PFLX has been developed and applied to the determination of PFLX in capsule and serum samples.

  10. Influence of crystalline structure on the luminescence properties of terbium orthotantalates

    Energy Technology Data Exchange (ETDEWEB)

    Siqueira, Kisla P.F. [Departamento de Química, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, ICEB II, Ouro Preto 35400-000, Minas Gerais (Brazil); Carmo, Alexandre P. [Instituto Federal Fluminense, Campus Cabo Frio, RJ 28909-971 (Brazil); Bell, Maria J.V. [Departamento de Física, Universidade Federal de Juiz de Fora, Juiz de Fora 36036-330, MG (Brazil); Dias, Anderson, E-mail: anderson_dias@iceb.ufop.br [Departamento de Química, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, ICEB II, Ouro Preto 35400-000, Minas Gerais (Brazil)

    2013-06-15

    Terbium orthotantalate powders were produced with M-fergusonite type (I2/a) and M′-fergusonite type (P2/a) structures. The samples were studied by X-ray diffraction, Raman scattering, and photoluminescence measurements (emission and decay curves). The results showed that crystalline materials were obtained with all the 18 Raman-active modes predicted by group theory calculations. Also, it was observed through photoluminescence decay curves that the Tb{sup 3+} ions occupies only one-symmetry site in both crystallographic arrangements. Photoluminescence emission curves exhibited some variation in spectral shape, peak position, and relative intensity as a consequence of their different crystalline arrangements. The dominated emission of Tb{sup 3+} ({sup 5}D{sub 4}→{sup 7}F{sub 5}) is centered with a maximum intensity at 549.2 nm (M-type) and 543.0 nm (M′-type). Fluorescence lifetimes for M-TbTaO{sub 4} and M′-TbTaO{sub 4} were determined as 33.4 μs and 1.25 ms, respectively. M′-type materials seems to be the most suitable for luminescent devices and could be a potential green luminescent material due to the strongest emission if compared with the M-fergusonite type. -- Highlights: ► Terbium orthotantalates were prepared in two different crystalline structures: I2/a and P2/a. ► XRD and Raman scattering showed that the different space groups obtained were exhibited all the 18 Raman-active modes. ► PL decay curves that the Tb{sup 3+} ions occupies only one-symmetry site in both crystallographic arrangements. ► Dominated emission of Tb{sup 3+} ({sup 5}D{sub 4}→{sup 7}F{sub 5}) is centered with a maximum intensity at 549 nm (M-type) and 543 nm (M′-type). ► Fluorescence lifetimes for M-TbTaO{sub 4} and M′-TbTaO{sub 4} were determined as 33.4 μs and 1.25 ms, respectively.

  11. Laser control and temperature switching of luminescence intensity in photostable transparent film based on terbium(III) β-diketonate complex

    Science.gov (United States)

    Lapaev, Dmitry V.; Nikiforov, Victor G.; Safiullin, Georgy M.; Lobkov, Vladimir S.; Salikhov, Kev M.; Knyazev, Andrey A.; Galyametdinov, Yury G.

    2014-11-01

    The study of the terbium(III) and gadolinium(III) β-diketonate complexes by photoluminescence spectroscopy reveals considerable changes of the photophysical properties of the complexes under the UV laser irradiation. The measurements show the enhancement of the luminescence intensities in the vitrified transparent film of the terbium(III) complex as well as the gadolinium(III) complex under the 337 nm laser irradiation at room temperature. The irradiated film of the terbium(III) complex restores the initial photophysical properties after heating close to the melting temperature (∼353 K) and cooling. We observe no change of the luminescent properties of the irradiated film for months. These features can be used for the design of new lanthanide-based photostable systems with laser control of the luminescence intensity.

  12. Development of functionalized terbium fluorescent nanoparticles for antibody labeling and time-resolved fluoroimmunoassay application.

    Science.gov (United States)

    Ye, Zhiqiang; Tan, Mingqian; Wang, Guilan; Yuan, Jingli

    2005-01-15

    Silica-based functionalized terbium fluorescent nanoparticles were prepared, characterized and developed as a fluorescence probe for antibody labeling and time-resolved fluoroimmunoassay. The nanoparticles were prepared in a water-in-oil (W/O) microemulsion containing a strongly fluorescent Tb(3+) chelate, N,N,N(1),N(1)-[2,6-bis(3'-aminomethyl-1'-pyrazolyl)phenylpyridine] tetrakis(acetate)-Tb(3+) (BPTA-Tb(3+)), Triton X-100, octanol, and cyclohexane by controlling copolymerization of tetraethyl orthosilicate (TEOS) and 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane (AEPS) with ammonia water. The characterizations by transmission electron microscopy and fluorometric methods show that the nanoparticles are spherical and uniform in size, 45 +/- 3nm in diameter, strongly fluorescent with fluorescence quantum yield of 10% and a long fluorescence lifetime of 2.0ms. The amino groups directly introduced to the nanoparticle's surface by using AEPS in the preparation made the surface modification and bioconjugation of the nanoparticles easier. The nanoparticle-labeled anti-human alpha-fetoprotein antibody was prepared and used for time-resolved fluoroimmunoassay of alpha-fetoprotein (AFP) in human serum samples. The assay response is linear from 0.10ngml(-1) to about 100ngml(-1) with the detection limit of 0.10ngml(-1). The coefficient variations (CVs) of the method are less than 9.0%, and the recoveries are in the range of 84-98% for human serum sample measurements.

  13. Highly efficient precipitation of phosphoproteins using trivalent europium, terbium, and erbium ions

    Energy Technology Data Exchange (ETDEWEB)

    Guezel, Yueksel; Rainer, Matthias; Mirza, Munazza Raza; Bonn, Guenther K. [Leopold-Franzens University, Institute of Analytical Chemistry and Radiochemistry, Innsbruck (Austria)

    2012-05-15

    This study describes a highly efficient method for the selective precipitation of phosphoproteins by trivalent europium, terbium, and erbium metal ions. These metal cations belong to the group of lanthanides and are known to be hard acceptors with an overwhelming preference for oxygen-containing anions such as phosphates to which they form very tight ionic bonds. The method could be successfully applied to specifically precipitate phosphoproteins from complex samples including milk and egg white by forming solid metal-protein complexes. Owing to the low solubility product of the investigated lanthanide salts, the produced metal-protein complexes showed high stability. The protein pellets were extensively washed to remove nonphosphorylated proteins and contaminants. For the analysis of proteins the pellets were first dissolved in 30 % formic acid and subjected to matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) MS. For peptide mass-fingerprint analysis the precipitated phosphoproteins were enzymatically digested using microwave-assisted digestion. The method was found to be highly specific for the isolation and purification of phosphoproteins. Protein quantification was performed by colorimetric detection of total precipitated phosphoproteins and revealed more than 95 % protein recovery for each lanthanide salt. (orig.)

  14. A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations

    Directory of Open Access Journals (Sweden)

    Salma M.Z. Al-Kindy

    2014-12-01

    Full Text Available A sensitive time-resolved luminescence method for the determination of flubiprofen (FLP in methanol and in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb3+ by the formation of a ternary complex with FLP in the presence of 4,7 diphenyl 1,10 phenanthroline (DPP as co-ligand, and Tween-20 as surfactant. The signal for Tb-FLP-DPP was monitored at λex  = 285 nm and λem  = 552 nm. Optimum conditions for the formation of the complex in an aqueous system were TRIS buffer, pH 8.0, DPP (2.5Å~10−7  M, Tween-20 (0.30% and 4Å~10-5  mol L-1  of Tb3+  which allowed the determination of 20–1000 ng mL-1  of FLP with a limit of detection (LOD of 10 ng mL-1 . The relative standard deviations of the method ranged between 0.6 and 1.4% indicating excellent reproducibility of the method. The proposed method was successfully applied for the assays of FLP in pharmaceutical formulations and spiked tap water samples with average recoveries of 87% – 95%.

  15. Sensitization effects of supramolecular assemblies on the luminescence of terbium-ion prulifloxacin complexes

    Energy Technology Data Exchange (ETDEWEB)

    Wang Hong; Yi Chongyue; Li Xue; Fang Fang [School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Yang Yajiang, E-mail: yjyang@mail.hust.edu.c [School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2011-04-15

    Luminescence enhancement of terbium-ion prulifloxacin complexes (Tb(III)-PUFX) in supramolecular hydrogels formed by assembly of 1,3:2,4-di-O-benzylidene-D-sorbitol (DBS) was investigated by steady-state fluorescence, varying temperature fluorescence and time-resolved fluorescence. The luminescence images show that Tb(III)-PUFX were dispersed in the DBS gels. The luminescence intensity of Tb(III)-PUFX in the DBS gels was significantly increased in comparison with that in corresponding aqueous solutions. The varying temperature fluorescent spectra show that the luminescence intensity of Tb(III)-PUFX decreased with an increase in the temperature. This implies that the luminescence enhancement of Tb(III)-PUFX is related to the dissociation and the formation of the DBS assemblies. Time-resolved fluorescence measurements show slower rotational motion in DBS gels in comparison with that in the corresponding aqueous solutions. This may be ascribed to a unique microstructure of three-dimensional network formed by DBC aggregates, resulting in deactivation of the nonradiative relaxation. The images of field emission scanning electron microscopy and polarized optical microscopy indicate that the morphology of the DBS assemblies was not influenced upon addition of Tb(III)-PUFX to the DBS gels.

  16. A Nanoscale Multiresponsive Luminescent Sensor Based on a Terbium(III) Metal-Organic Framework.

    Science.gov (United States)

    Dang, Song; Wang, Ting; Yi, Feiyan; Liu, Qinghui; Yang, Weiting; Sun, Zhong-Ming

    2015-08-01

    A nanoscale terbium-containing metal-organic framework (nTbL), with a layer-like structure and [H2 NMe2 ](+) cations located in the framework channels, was synthesized under hydrothermal conditions. The structure of the as-prepared sample was systematically confirmed by powder XRD and elemental analysis; the morphology was characterized by field-emission SEM and TEM. The photoluminescence studies revealed that rod-like nTbL exhibited bright-green emission, corresponding to (5)D4 →(7)FJ (J=6-3) transitions of the Tb(3+) ion under excitation. Further sensing measurements revealed that as-prepared nTbL could be utilized as a multiresponsive luminescent sensor, which showed significant and exclusive detection ability for Fe(3+) ions and phenylmethanol. These results highlight the practical applications of lanthanide-containing metal-organic frameworks as fluorescent probes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Terbium-Doped VO2 Thin Films: Reduced Phase Transition Temperature and Largely Enhanced Luminous Transmittance.

    Science.gov (United States)

    Wang, Ning; Duchamp, Martial; Dunin-Borkowski, Rafal E; Liu, Shiyu; Zeng, XianTing; Cao, Xun; Long, Yi

    2016-01-26

    Vanadium dioxide (VO2) is a well-known thermochromic material with large IR modulating ability, promising for energy-saving smart windows. The main drawbacks of VO2 are its high phase transition temperature (τ(c) = 68°C), low luminous transmission (T(lum)), and weak solar modulating ability (ΔT(sol)). In this paper, the terbium cation (Tb(3+)) doping was first reported to reduce τ(c) and increase T(lum) of VO2 thin films. Compared with pristine VO2, 2 at. % doping level gives both enhanced T(lum) and ΔT(sol) from 45.8% to 54.0% and 7.7% to 8.3%, respectively. The T(lum) increases with continuous Tb(3+) doping and reaches 79.4% at 6 at. % doping level, representing ∼73.4% relative increment compared with pure VO2. This has surpassed the best reported doped VO2 thin films. The enhanced thermochromic properties is meaningful for smart window applications of VO2 materials.

  18. Luminescent investigations of terbium(III) biosorption as a surrogate for heavy metals and radionuclides.

    Science.gov (United States)

    Achyuthan, Komandoor E; Arango, Dulce C; Carles, Elizabeth L; Cutler, Christopher E; Meyer, Lauren A; Brozik, Susan M

    2009-07-01

    We describe a metal transport system for investigating the interfacial interactions between the anionic surface charge of a gram-negative bacterium (Escherichia coli) and a trivalent cationic metal, Tb3+. We believe this is the first description of the uptake kinetics, sub- and intracellular distribution, and temporal fate of Tb3+ ion in E. coli. We used the luminescence of the terbium-dipicolinic acid chelate to study metal ion transport. The bacteria had a high tolerance for the metal (IC(50) = 4 mM Tb3+). Metal ion transport was passive and metabolism independent. The uptake kinetics rapidly reached a maximum within 15 min, followed by a stasis for 60 min, and declining thereafter between 120 and 240 min, resulting in a biphasic curve. During this period, greater than one-third of the metal ion was sequestered within the cell. Our choice of a safe Biosafety Level I E. coli bacteria and the relatively non-toxic Tb3+ metal represents a model system for luminescent investigations of biosorption, for studying bacterial-water interfacial chemistry and for the bioremediation of heavy metals and radionuclides.

  19. 40 CFR 158.2080 - Experimental use permit data requirements-biochemical pesticides.

    Science.gov (United States)

    2010-07-01

    ... requirements-biochemical pesticides. 158.2080 Section 158.2080 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2080 Experimental use permit data requirements—biochemical pesticides. (a) Sections 158.2081...

  20. Construction of the energy matrix for complex atoms. Part VIII: Hyperfine structure HPC calculations for terbium atom

    Science.gov (United States)

    Elantkowska, Magdalena; Ruczkowski, Jarosław; Sikorski, Andrzej; Dembczyński, Jerzy

    2017-11-01

    A parametric analysis of the hyperfine structure (hfs) for the even parity configurations of atomic terbium (Tb I) is presented in this work. We introduce the complete set of 4fN-core states in our high-performance computing (HPC) calculations. For calculations of the huge hyperfine structure matrix, requiring approximately 5000 hours when run on a single CPU, we propose the methods utilizing a personal computer cluster or, alternatively a cluster of Microsoft Azure virtual machines (VM). These methods give a factor 12 performance boost, enabling the calculations to complete in an acceptable time.

  1. Spectrofluorimetric determination of human serum albumin using terbium-danofloxacin probe.

    Science.gov (United States)

    Ramezani, Amir M; Manzoori, Jamshid L; Amjadi, Mohammad; Jouyban, Abolghasem

    2012-01-01

    A spectrofluorimetric method is proposed for the determination of human serum albumin (HSA) and bovine serum albumin (BSA) using terbium-danofloxacin (Tb(3+)-Dano) as a fluorescent probe. These proteins remarkably enhance the fluorescence intensity of the Tb(3+)-Dano complex at 545 nm, and the enhanced fluorescence intensity of Tb(3+)-Dano is proportional to the concentration of proteins (HSA and BSA). Optimum conditions for the determination of HSA were investigated and found that the maximum response was observed at: pH = 7.8, [Tb(3+)] = 8.5 × 10(-5) mol L(-1), [Dano] = 1.5 × 10(-4) mol L(-1). The calibration graphs for standard solutions of BSA, HSA, and plasma samples of HSA were linear in the range of 0.2 × 10(-6) - 1.3 × 10(-6) mol L(-1), 0.2 × 10(-6) - 1.4 × 10(-6) mol L(-1), and 0.2 × 10(-6) - 1 × 10(-6) mol L(-1), respectively. The detection limits (S/N = 3) for BSA, HSA, and plasma sample of HSA were 8.7 × 10(-8) mol L(-1), 6.2 × 10(-8) mol L(-1), and 8.1 × 10(-8) mol L(-1), respectively. The applicability of the method was checked using a number of real biological plasma samples and was compared with the UV spectrometric reference method. The results was showed that the method could be regarded as a simple, practical, and sensitive alternative method for determination of albumin in biological samples.

  2. Spectrofluorimetric Determination of Human Serum Albumin Using Terbium-Danofloxacin Probe

    Directory of Open Access Journals (Sweden)

    Amir M. Ramezani

    2012-01-01

    Full Text Available A spectrofluorimetric method is proposed for the determination of human serum albumin (HSA and bovine serum albumin (BSA using terbium-danofloxacin (Tb3+-Dano as a fluorescent probe. These proteins remarkably enhance the fluorescence intensity of the Tb3+-Dano complex at 545 nm, and the enhanced fluorescence intensity of Tb3+-Dano is proportional to the concentration of proteins (HSA and BSA. Optimum conditions for the determination of HSA were investigated and found that the maximum response was observed at: pH=7.8, [Tb3+] =8.5×10−5 mol L−1, [Dano] =1.5×10−4 mol L−1. The calibration graphs for standard solutions of BSA, HSA, and plasma samples of HSA were linear in the range of 0.2×10−6−1.3×10−6 mol L−1, 0.2×10−6−1.4×10−6 mol L−1, and 0.2×10−6−1×10−6 mol L−1, respectively. The detection limits (S/N = 3 for BSA, HSA, and plasma sample of HSA were 8.7×10−8 mol L−1, 6.2×10−8 mol L−1, and 8.1×10−8 mol L−1, respectively. The applicability of the method was checked using a number of real biological plasma samples and was compared with the UV spectrometric reference method. The results was showed that the method could be regarded as a simple, practical, and sensitive alternative method for determination of albumin in biological samples.

  3. Determination of flavonoids in pharmaceutical preparations using Terbium sensitized fluorescence method

    Directory of Open Access Journals (Sweden)

    M Shaghaghi

    2009-12-01

    Full Text Available "nBackground and the Purpose of the Study: The aim of this study was development and validation of a simple, rapid and sensitive spectrofluorimetric method for determination of total flavonoids in two topical formulations of Calendula officinalis, Ziziphus Spina-christi and an oral drop of Hypiran perforatum L. The proposed method is based on the formation of terbium (Tb3+ "n-flavonoids (quercetin as a reference standard complex at pH 7.0, which has fluorescence intensely with maximum emission at 545 nm when excited at 310 nm. "nMethod "n: For ointments masses of topical formulations were weighed and added to ethanol-aqueous buffer (pH 10.0 and the resulting mixtures were shaken and then two phases were separated by centrifugation. Aqueous phases were filtered and then diluted with water. For Hypiran drops an appropriate portion was diluted with ethanol and then aliquots of sample or standard solutions were determined according to the experimental procedure. "nResults "n: Under the optimum conditions, total concentrations of flavonoids (as quercetin equivalent in three tested formulations were found to be 0.204 mg/g (for Dermatin cream, 0.476 mg/g (for Calendula ointment and 13.50 μg/ml (for Hypiran drops. Analytical recoveries from samples spiked with different amounts of quercetin were 96.1-104.0 % with RSD % of less than 3.5. Conclusion : The proposed method which requires a simple dissolution step without any matrix interferences provided high sensitivity and selectivity and was easily applied to determine total flavonoids in real samples of three investigated formulations with excellent reproducibility.

  4. TOF SIMS analysis and generation of white photoluminescence from strontium silicate codoped with europium and terbium

    Energy Technology Data Exchange (ETDEWEB)

    Tshabalala, Modiehi A.; Swart, Hendrik C.; Ntwaeaborwa, Odireleng M., E-mail: ntwaeab@ufs.ac.za [Department of Physics, University of the Free State, P.O Box 339, Bloemfontein 9300 South Africa (South Africa)

    2014-03-15

    White light emitting terbium (Tb{sup 3+}) and europium (Eu{sup 3+}) codoped strontium silicate (Sr{sub 2}SiO{sub 4}) phosphors were prepared by a solid state reaction process. The structure, particle morphology, chemical composition, ion distribution, photoluminescence (PL), and decay characteristics of the phosphors were analyzed by x-ray diffraction (XRD), scanning electron microscopy (SEM), time-of-flight secondary ion mass spectrometry (TOF-SIMS), and PL spectroscopy, respectively. The XRD data showed that our Sr{sub 2}SiO{sub 4} composed of two phases, namely, β-Sr{sub 2}SiO{sub 4} and α′-Sr{sub 2}SiO{sub 4}, and the α′-Sr{sub 2}SiO{sub 4} phase was more prominent than the β-Sr{sub 2}SiO{sub 4} phase. The SEM micrographs showed that the particles were agglomerated together and they did not have definite shapes. All ions (i.e., negative and positive) present in our materials were identified by TOF-SIMS. In addition, the chemical imaging performed with the TOF-SIMS demonstrated how the individual ions including the dopants (Eu{sup 3+} and Tb{sup 3+}) were distributed in the host lattice. White photoluminescence was observed when the Sr{sub 2}SiO{sub 4}:Tb{sup 3+}, Eu{sup 3+} phosphor was excited at 239 nm using a monochromatized xenon lamp as the excitation source. The phosphor exhibited fast decay lifetimes implying that it is not a good candidate for long afterglow applications.

  5. Phenotype abnormality: 158 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 158 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u664i decreased efficiency... in organ named root hair cell during process named organ development ... root hair cell ... decreased efficiency ... organ development ...

  6. 40 CFR 158.110 - Required and conditionally required data.

    Science.gov (United States)

    2010-07-01

    ...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES How To Use Data Tables § 158.110 Required and... use pattern in order to evaluate the risks or benefits of a product having that use pattern under any... with a given use pattern are required by EPA to evaluate the risks or benefits of a product having that...

  7. 40 CFR 158.1 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... FIFRA secs. 3, 4, and 5 about the risks and benefits of pesticide products. Further, this part specifies... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES General Provisions § 158.1 Purpose and scope. (a) Purpose. The purpose of this part is...

  8. 29__154 -158_ _Galadanci_ANALYSIS OF AURORAL

    African Journals Online (AJOL)

    User

    Bayero Journal of Pure and Applied Sciences, 9(2): 154 - 158. Received: April, 2016. Accepted: August, 2016 ... 1Department of Physics, Bayero University, Kano. NIGERIA. 2Department of Mathematical Sciences, Bayero ... first described by a Japanese geophysicist named. Syun-IchiAkasofu in 1964 (Sarris and Li, 2005).

  9. 14 CFR 158.67 - Recordkeeping and auditing: Public agency.

    Science.gov (United States)

    2010-01-01

    ... collected, held or used, each public agency shall provide for an audit of its PFC account. The audit shall... audit may be— (1) Performed specifically for the PFC account; or (2) Conducted as part of an audit under... TRANSPORTATION (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Reporting, Recordkeeping and Audits § 158...

  10. Image collection: 158 [Togo Picture Gallery[Archive

    Lifescience Database Archive (English)

    Full Text Available 158 Camelus_dromedarius_NL.png ヒトコブラクダ Dromedary Camelus dromedarius 9838 生物アイコン,脊索動物門,脊椎動物亜門,哺乳綱,獣亜綱,真獣下綱,ウシ目

  11. 14 CFR 158.20 - Submission of required documents.

    Science.gov (United States)

    2010-01-01

    ... due to the security process. (b) Once the database development is completed with air carrier capability, public agencies and air carriers may use the FAA's national PFC database to post their required... Section 158.20 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  12. Effect Alpha Globlin Gene Deletion And Gamma Globin Gene -158 ...

    African Journals Online (AJOL)

    We studied the Xmn1 polymorphism (C/T) in γ- globin gene position -158 of β- thalassemia as a modulating factor of the disease severity. Presence of the polymorphism was found in two patients and this was not sufficient to explain the diversity of the phenotype encountered. Co-inheritance of alpha thalassaemia as a ...

  13. Synthesis, crystal structure and photophysical properties of europium(III) and terbium(III) complexes with pyridine-2,6-dicarboxamide

    NARCIS (Netherlands)

    Tanase, S.; Gallego, P.M.; Gelder, R. de; Fu, W.T.

    2007-01-01

    The reactions of pyridine-2,6-dicarboxamide with europium(III) and terbium(III) triflates led to the formation of mononuclear complexes of formula [Ln(pcam)(3)](CF3SO3)(3) (Ln = Eu 1, Tb 2; pcam stands for pyridine-2,6-dicarboxamide). From single-crystal X-ray diffraction analysis, the complexes

  14. Zinc sulfide and terbium-doped zinc sulfide films grown by traveling wave reactor atomic layer epitaxy

    CERN Document Server

    Yun, S J; Nam, K S

    1998-01-01

    Zinc sulfide (ZnS) and terbium-doped ZnS (ZnS:Tb) thin films were grown by traveling wave reactor atomic layer epitaxy (ALE). In the present work, ZnCl sub 2 , H sub 2 S, and tris (2,2,6,6-tetramethyl-3,5-heptandionato) terbium (Tb(tmhd) sub 3) were used as the precursors. The dependence of crystallinity and Cl content of ZnS films was investigated on the growth temperature. ZnS and ZnS:Tb films grown at temperatures ranging from 400 to 500 .deg. C showed a hexagonal-2H crystalline structure. The crystallinity of ZnS film was greatly enhanced as the temperature increased. At growth temperatures higher than 450.deg.C, the films showed preferred orientation with mainly (002) diffraction peak. The Cl content decreased from approximately 9 to 1 at.% with the increase in growth temperature from 400 to 500 .deg. C. The segregation of Cl near the surface region and the incorporation of O from Tb(tmhd) sub 3 during ALE process were also observed using Auger electron spectroscopy. The ALE-grown ZnS and ZnS:Tb films re...

  15. Commercializing potassium terbium fluoride, KTF (KTb3F10) faraday crystals for high laser power optical isolator applications

    Science.gov (United States)

    Schlichting, Wolfgang; Stevens, Kevin; Foundos, Greg; Payne, Alexis

    2017-10-01

    Many scientific lasers and increasingly industrial laser systems operate in power regime, require high-performance optical isolators to prevent disruptive light feedback into the laser cavity. The optically active Faraday material is the key optical element inside the isolator. SYNOPTICS has been supplying the laser market with Terbium Gallium Garnet (TGG - Tb3Ga5O12) for many years. It is the most commonly used material for the 650-1100nm range and the key advantages for TGG include its cubic crystal structure for alignment free processing, little to no intrinsic birefringence, and ease of manufacture. However, for high-power laser applications TGG is limited by its absorption at 1064nm and its thermo-optic coefficient, dn/dT. Specifically, thermal lensing and depolarization effects become a limiting factor at high laser powers. While TGG absorption has improved significantly over the past few years, there is an intrinsic limit. Now, SYNOPTICS is commercializing the enhanced new crystal Potassium Terbium Fluoride KTF (KTb3F10) that exhibits much smaller nonlinear refractive index and thermo-optic coefficients, and still exhibits a Verdet constant near that of TGG. This cubic crystal has relatively low absorption and thermo-optic coefficients. It is now fully characterized and available for select production orders. At OPTIFAB in October 2017 we present recent results comparing the performance of KTF to TGG in optical isolators and show SYNOPTICS advances in large volume crystal growth and the production ramp up.

  16. Preparation and photoluminescence enhancement in terbium(III ternary complexes with β-diketone and monodentate auxiliary ligands

    Directory of Open Access Journals (Sweden)

    Devender Singh

    2016-12-01

    Full Text Available A series of new solid ternary complexes of terbium(III ion based on β-diketone ligand acetylacetone (acac and monodentate auxiliary ligands (aqua/urea/triphenylphosphineoxide/pyridine-N-oxide had been prepared. The structural characterizations of synthesized ternary compounds were studied by means of elemental analysis, infrared (IR, and proton nuclear magnetic resonance (NMR spectral techniques. The optical characteristics were investigated with absorption as well as photoluminescence spectroscopy. Thermal behavior of compounds was examined by TGA/DTA analysis and all metal complexes were found to have good thermal stability. The luminescence decay time of complexes were also calculated by monitoring at emission wavelength corresponding to 5D4 → 7F5 transition. A comparative inspection of the luminescent behavior of prepared ternary compounds was performed in order to determine the function of auxiliary ligands in the enhancement of luminescence intensity produced by central terbium(III ion. The color coordinates values suggested that compounds showed bright green emission in visible region in electromagnetic spectrum. Complexes producing green light could play a significant role in the fabrication of efficient light conversion molecular devices for display purposes and lightning systems.

  17. 9 CFR 381.158 - Poultry dinners (frozen) and pies.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Poultry dinners (frozen) and pies. 381... Composition § 381.158 Poultry dinners (frozen) and pies. Poultry dinners (frozen) and pies shall meet the... kind indicated Percent Weight (Kind) Pies 14 or 11/8 oz. per 8-oz. pie 1 25 or 2 oz. per 8-oz. pie. 1...

  18. Synthesis and luminescent study of Ce{sup 3+}-doped terbium-yttrium aluminum garnet

    Energy Technology Data Exchange (ETDEWEB)

    Dotsenko, V.P., E-mail: ssclab@ukr.net [A.V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, Lustdorfskaya doroga 86, 65080 Odessa (Ukraine); Berezovskaya, I.V.; Zubar, E.V.; Efryushina, N.P. [A.V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, Lustdorfskaya doroga 86, 65080 Odessa (Ukraine); Poletaev, N.I.; Doroshenko, Yu.A. [Institute of Combustion and Advanced Technologies, Mechnikov Odessa National University, Dvoryanskaya 2, 65082 Odessa (Ukraine); Stryganyuk, G.B. [Ivan Franko National University of Lviv, Kirilo i Mefodii 8, 79005 Lviv (Ukraine); HASYLAB at DESY, Notkestrasse 85, 22607 Hamburg (Germany); Voloshinovskii, A.S. [Ivan Franko National University of Lviv, Kirilo i Mefodii 8, 79005 Lviv (Ukraine)

    2013-02-15

    Highlights: Black-Right-Pointing-Pointer Ce{sup 3+}-doped garnets (TYAG) were prepared using nanostructured reagents. Black-Right-Pointing-Pointer The Ce{sup 3+} ions cause a very efficient yellow emission of the samples. Black-Right-Pointing-Pointer The reasons for the long wavelength position of this emission are discussed. Black-Right-Pointing-Pointer Contribution from Al atoms to the conduction band of TYAG is quite essential. - Abstract: Terbium-yttrium aluminum garnets (TYAG) doped with Ce{sup 3+} ions have been prepared by solid state reactions between nanostructured oxides of aluminum and rare earths. The luminescent properties of Ce{sup 3+} ions in (Tb{sub 0.8}Y{sub 0.2}){sub 3(1-x)}Ce{sub 3x}Al{sub 5}O{sub 12} (x = 0.03) have been studied upon excitation in the 2-20 eV region. The substitution of Tb{sup 3+} for Y{sup 3+} in the garnet structure results in broadening the emission band and shifting its maximum towards the longer wavelengths. It was found that in addition to the 4f{sup n} {yields} 4f{sup n-1}5d excitation bands of Ce{sup 3+} and Tb{sup 3+} ions, the excitation spectra for the Ce{sup 3+} emission contain broad bands at 6.73 and {approx}9.5 eV. These bands are attributed to the Ce{sup 3+}-bound exciton formation and O 2p {yields} Al 3s, 3p transitions, respectively. In contrast to the predictions based on the results of electronic structure calculations on Y{sub 3}Al{sub 5}O{sub 12} and Tb{sub 4}Al{sub 2}O{sub 9}, the threshold of interband transitions in TYAG is at high energies ( Greater-Than-Or-Slanted-Equal-To 7.3 eV), and contributions from Al{sub tetr} and Al{sub oct} atoms to the conduction-band density of states are evaluated as quite essential.

  19. Structural variations in terbium(III) complexes with 1,3-adamantanedicarboxylate and diverse co-ligands

    Energy Technology Data Exchange (ETDEWEB)

    Thuéry, Pierre, E-mail: pierre.thuery@cea.fr

    2015-07-15

    Terbium nitrate was reacted with 1,3-adamantanedicarboxylic acid (LH{sub 2}) under solvo-hydrothermal conditions with either N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMA) as organic solvents. Hydrolysation of the latter co-solvents resulted in the formation of formate or acetate ions, which are present as co-ligands in the 1D coordination polymer [Tb(L)(HCOO)(H{sub 2}O){sub 2}] (1) and the 2D assembly [Tb(L)(CH{sub 3}COO)(H{sub 2}O)] (2). The increase in dimensionality in the latter arises from the higher connectivity provided by acetate versus formate, the L{sup 2−} ligand being bis-chelating in both cases. The complex [Tb{sub 2}(L){sub 3}(H{sub 2}O){sub 5}][Tb{sub 2}(L){sub 3}(H{sub 2}O){sub 4}]·3H{sub 2}O (3), another 1D species, crystallizes alongside crystals of 2. Further addition of cucurbit[6]uril (CB6), with DMF as co-solvent, gave the two complexes [Tb{sub 2}(L){sub 2}(CB6)(H{sub 2}O){sub 6}](NO{sub 3}){sub 2}·6H{sub 2}O (4) and [H{sub 2}NMe{sub 2}]{sub 2}[Tb(L)(HCOO){sub 2}]{sub 2}·CB6·3H{sub 2}O (5). Complex 4 crystallizes as a 3D framework in which Tb(L){sup +} chains are connected by tetradentate CB6 molecules, while 5 unites a carboxylate-bridged anionic 2D planar assembly and layers of CB6 molecules with counter-cations held at both portals. - Graphical abstract: One- to three-dimensional assemblies are formed in terbium(III) complexes with 1,3-adamantanedicarboxylate obtained under solvo-hydrothermal conditions, these species including formate or acetate co-ligands formed in situ, or additional cucurbit[6]uril molecules. - Highlights: • We report structures of terbium(III) complexes with 1,3-adamantanedicarboxylate. • Solvents able to generate co-ligands or counter-ions in situ have been used. • A 3D species including additional cucurbituril molecules is decribed. • One species displays an alternation of metal–organic and organic sheets.

  20. 40 CFR 158.2083 - Experimental use permit biochemical pesticides human health assessment data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pesticides human health assessment data requirements table. 158.2083 Section 158.2083 Protection of... Biochemical Pesticides § 158.2083 Experimental use permit biochemical pesticides human health assessment data... determine the human health assessment data requirements for a particular biochemical pesticide product. (2...

  1. 40 CFR 158.2120 - Microbial pesticides product analysis data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides product analysis data requirements table. 158.2120 Section 158.2120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2120 Microbial pesticides product analysis data...

  2. 40 CFR 158.2171 - Experimental use permit microbial pesticides product analysis data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Experimental use permit microbial pesticides product analysis data requirements table. 158.2171 Section 158.2171 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2171 Experimental use...

  3. 21 CFR 133.158 - Low-moisture part-skim mozzarella and scamorza cheese.

    Science.gov (United States)

    2010-04-01

    ... cheese. 133.158 Section 133.158 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.158 Low-moisture part-skim mozzarella and...

  4. 40 CFR 158.2130 - Microbial pesticides residue data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides residue data... (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2130 Microbial pesticides residue data requirements table. (a) General. Sections 158.100 through 158.130 describe how to use...

  5. 40 CFR 158.2174 - Experimental use permit microbial pesticides nontarget organisms and environmental fate data...

    Science.gov (United States)

    2010-07-01

    ... pesticides nontarget organisms and environmental fate data requirements table. 158.2174 Section 158.2174 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2174 Experimental use permit microbial pesticides nontarget...

  6. 40 CFR 158.2173 - Experimental use permit microbial pesticides toxicology data requirements table.

    Science.gov (United States)

    2010-07-01

    ... pesticides toxicology data requirements table. 158.2173 Section 158.2173 Protection of Environment... Pesticides § 158.2173 Experimental use permit microbial pesticides toxicology data requirements table. (a...: (c) Table. The following table shows the data requirements for microbial pesticide toxicology. The...

  7. 40 CFR 158.230 - Experimental use permit data requirements for toxicology.

    Science.gov (United States)

    2010-07-01

    ... requirements for toxicology. 158.230 Section 158.230 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Experimental Use Permits § 158.230 Experimental use permit data requirements for toxicology. All toxicology data, as described in paragraph (c) of...

  8. 78 FR 5773 - Approval for Manufacturing Authority, Foreign-Trade Zone 158, Morgan Fabrics Corporation...

    Science.gov (United States)

    2013-01-28

    ... Foreign-Trade Zones Board Approval for Manufacturing Authority, Foreign-Trade Zone 158, Morgan Fabrics... Foreign-Trade Zone 158, has requested manufacturing authority on behalf of Morgan Fabrics Corporation... application for manufacturing authority under zone procedures within FTZ 158 on behalf of Morgan Fabrics...

  9. 40 CFR 158.2172 - Experimental use permit microbial pesticides residue data requirements table.

    Science.gov (United States)

    2010-07-01

    ... results of testing: i. Indicate the potential to cause adverse human health effects or the product... pesticides residue data requirements table. 158.2172 Section 158.2172 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158...

  10. 7 CFR 1717.158 - Mergers with borrowers who prepaid RUS loans.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Mergers with borrowers who prepaid RUS loans. 1717.158 Section 1717.158 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... GUARANTEED ELECTRIC LOANS Mergers and Consolidations of Electric Borrowers § 1717.158 Mergers with borrowers...

  11. 40 CFR 158.510 - Tiered testing options for nonfood pesticides.

    Science.gov (United States)

    2010-07-01

    ... pesticides. 158.510 Section 158.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Toxicology § 158.510 Tiered testing options for nonfood pesticides. For nonfood use pesticides only, applicants have two options for generating and submitting...

  12. 40 CFR 158.2170 - Experimental use permit data requirements-microbial pesticides.

    Science.gov (United States)

    2010-07-01

    ... requirements-microbial pesticides. 158.2170 Section 158.2170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2170 Experimental use permit data requirements—microbial pesticides. (a) For all microbial pesticides. (1) The...

  13. Complete Stokes polarimetry of magneto-optical Faraday effect in a terbium gallium garnet crystal at cryogenic temperatures.

    Science.gov (United States)

    Majeed, Hassaan; Shaheen, Amrozia; Anwar, Muhammad Sabieh

    2013-10-21

    We report the complete determination of the polarization changes caused in linearly polarized incident light due to propagation in a magneto-optically active terbium gallium garnet (TGG) single crystal, at temperatures ranging from 6.3 to 300 K. A 28-fold increase in the Verdet constant of the TGG crystal is seen as its temperature decreases to 6.3 K. In contrast with polarimetry of light emerging from a Faraday material at room temperature, polarimetry at cryogenic temperatures cannot be carried out using the conventional fixed polarizer-analyzer technique because the assumption that ellipticity is negligible becomes increasingly invalid as temperature is lowered. It is shown that complete determination of light polarization in such a case requires the determination of its Stokes parameters, otherwise inaccurate measurements will result with negative implications for practical devices.

  14. Development of Optical Isolators for Visible Light Using Terbium Aluminum Garnet (Tb3Al5O12) Single Crystals

    Science.gov (United States)

    Geho, Mikio; Takagi, Takashi; Chiku, Shinichiro; Fujii, Takashi

    2005-07-01

    We have recently reported the successful growth of incongruently melting terbium aluminum garnet (Tb3Al5O12; TAG) single crystals by the hybrid laser FZ (floating zone) method. Optical property evaluations confirmed a high transmittance and a larger Verdet constant than conventional Tb3Ga5O12 (TGG) crystals and/or Faraday glasses. In this study, we attempted to design, fabricate, and evaluate optical isolators in visible light through near-infrared (NIR) regions using TAG crystals. A finite element method (FEM) simulation of possible models led us to the preferable one based on a radially magnetized magnet. To realize this, we employed a pseudo-radially magnetized magnet. The target wavelengths of the prototype device were 408, 808, and 1064 nm. The typical extinction ratio was more than 30 dB and the insertion loss was less than 0.3 dB for AR-coated devices.

  15. A hydrometallurgical process for the recovery of terbium from fluorescent lamps: Experimental design, optimization of acid leaching process and process analysis.

    Science.gov (United States)

    Innocenzi, Valentina; Ippolito, Nicolò Maria; De Michelis, Ida; Medici, Franco; Vegliò, Francesco

    2016-12-15

    Terbium and rare earths recovery from fluorescent powders of exhausted lamps by acid leaching with hydrochloric acid was the objective of this study. In order to investigate the factors affecting leaching a series of experiments was performed in according to a full factorial plan with four variables and two levels (4 2 ). The factors studied were temperature, concentration of acid, pulp density and leaching time. Experimental conditions of terbium dissolution were optimized by statistical analysis. The results showed that temperature and pulp density were significant with a positive and negative effect, respectively. The empirical mathematical model deducted by experimental data demonstrated that terbium content was completely dissolved under the following conditions: 90 °C, 2 M hydrochloric acid and 5% of pulp density; while when the pulp density was 15% an extraction of 83% could be obtained at 90 °C and 5 M hydrochloric acid. Finally a flow sheet for the recovery of rare earth elements was proposed. The process was tested and simulated by commercial software for the chemical processes. The mass balance of the process was calculated: from 1 ton of initial powder it was possible to obtain around 160 kg of a concentrate of rare earths having a purity of 99%. The main rare earths elements in the final product was yttrium oxide (86.43%) following by cerium oxide (4.11%), lanthanum oxide (3.18%), europium oxide (3.08%) and terbium oxide (2.20%). The estimated total recovery of the rare earths elements was around 70% for yttrium and europium and 80% for the other rare earths. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Investigation of the luminescent properties of terbium-anthranilate complexes and application to the determination of anthranilic acid derivatives in aqueous solutions

    Energy Technology Data Exchange (ETDEWEB)

    Arnaud, N.; Georges, J

    2003-01-10

    The luminescent properties of terbium complexes with furosemide (FR), flufenamic (FF) acid, tolfenamic (TF) acid and mefenamic (MF) acid have been investigated in aqueous solutions. For all four compounds, complexation occurs when the carboxylic acid of the aminobenzoic group is dissociated and is greatly favoured in the presence of trioctylphosphine oxide as co-ligand and Triton X-100 as surfactant. Under optimum conditions, luminescence of the lanthanide ion is efficiently sensitised and the lifetime of the {sup 5}D{sub 4} resonance level of terbium in the complex is ranging between 1 and 1.9 ms, against 0.4 ms for the aqua ion. The sensitivity of the method for the determination of anthranilic acid derivatives is improved by one to two orders of magnitude with respect to that achieved using native fluorescence or terbium-sensitised luminescence in methanol. The limits of detection are 2x10{sup -10}, 5x10{sup -10} and 2x10{sup -9} mol l{sup -1} for flufenamic acid, furosemide and tolfenamic acid, and mefenamic acid, respectively, with within-run RSD values of less than 1%. The method has been applied to the determination of flufenamic acid in spiked calf sera with and without sample pretreatment. Depending on the method and the analyte concentration, the recovery was ranging between 83 and 113% and the lowest concentration attainable in serum samples was close to 1x10{sup -7} mol l{sup -1}.

  17. 19 CFR 158.26 - Loss or theft in public stores.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Loss or theft in public stores. 158.26 Section 158... Casualty, Loss, or Theft While in Customs Custody § 158.26 Loss or theft in public stores. In the case of alleged loss or theft while the merchandise is in the public stores, there shall be filed a declaration of...

  18. Structural investigation and photoluminescent properties of gadolinium(III), europium(III) and terbium(III) 3-mercaptopropionate complexes.

    Science.gov (United States)

    Souza, E R; Mazali, I O; Sigoli, F A

    2014-01-01

    This work reports on the synthesis, crystallographic determination and spectroscopic characterization of gadolinium(III), terbium(III) and europium(III) 3-mercaptopropionate complexes, aqua-tris(3-mercaptopropionate)lanthanide(III)--[Ln(mpa)3(H2O)]. The Judd-Ofelt intensity parameters were experimentally determined from emission spectrum of the [Eu(mpa)3(H2O)]complex and they were also calculated from crystallographic data. The complexes are coordination polymers, where the units of each complex are linked together by carboxylate groups leading to an unidimensional and parallel chains that by chemical interactions form a tridimensional framework. The emission spectrum profile of the [Eu(mpa)3(H2O)] complex is discussed based on point symmetry of the europium(III) ion, that explains the bands splitting observed in its emission spectrum. Photoluminescent analysis of the [Gd(mpa)3(H2O)] complex show no efficient ligand excitation but an intense charge transfer band. The excitation spectra of the [Eu(mpa)3(H2O)] and [Tb(mpa)3(H2O)] complexes do not show evidence of energy transfer from the ligand to the excited levels of these trivalent ions. Therefore the emission bands are originated only by direct f-f intraconfigurational excitation of the lantanide(III) ions.

  19. Fluorometric determination of proteins using the terbium (III)-2-thenoyltrifluoroacetone-sodium dodecyl benzene sulfonate-protein system

    Energy Technology Data Exchange (ETDEWEB)

    Jia Zhen [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Department of Chemistry, Dezhou University, Dezhou 253023 (China); Yang Jinghe [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China)]. E-mail: yjh@sdu.edu.cn; Wu Xia [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Wang Fei [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Guo Changying [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Liu Shufang [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China)

    2006-12-15

    It is found that in hexamethylene tetramine (HMTA)-HCl buffer of pH=8.00, proteins can enhance the fluorescence of terbium (III) (Tb{sup 3+})-2-thenoyltrifluoroacetone (TTA)-sodium dodecyl benzene sulfonate (SDBS) system. Based on this, a sensitive method for the determination of proteins is proposed. The experiments indicate that under the optimum conditions, the enhanced fluorescence intensity is in proportion to the concentration of proteins in the range of 4.0x10{sup -9}-7.5x10{sup -6}g/mL for bovine serum albumin (BSA), 5.0x10{sup -9}-1.5x10{sup -5}g/mL for human serum albumin (HSA), 1.0x10{sup -8}-7.5x10{sup -6}g/mL for egg albumin (EA). Their detection limits (S/N=3) are 0.5, 0.8 and 2.0ng/mL, respectively. The interaction mechanism is also studied.

  20. Terbium to Quantum Dot FRET Bioconjugates for Clinical Diagnostics: Influence of Human Plasma on Optical and Assembly Properties

    Directory of Open Access Journals (Sweden)

    Niko Hildebrandt

    2011-10-01

    Full Text Available Förster resonance energy transfer (FRET from luminescent terbium complexes (LTC as donors to semiconductor quantum dots (QDs as acceptors allows extraordinary large FRET efficiencies due to the long Förster distances afforded. Moreover, time-gated detection permits an efficient suppression of autofluorescent background leading to sub-picomolar detection limits even within multiplexed detection formats. These characteristics make FRET-systems with LTC and QDs excellent candidates for clinical diagnostics. So far, such proofs of principle for highly sensitive multiplexed biosensing have only been performed under optimized buffer conditions and interactions between real-life clinical media such as human serum or plasma and LTC-QD-FRET-systems have not yet been taken into account. Here we present an extensive spectroscopic analysis of absorption, excitation and emission spectra along with the luminescence decay times of both the single components as well as the assembled FRET-systems in TRIS-buffer, TRIS-buffer with 2% bovine serum albumin, and fresh human plasma. Moreover, we evaluated homogeneous LTC-QD FRET assays in QD conjugates assembled with either the well-known, specific biotin-streptavidin biological interaction or, alternatively, the metal-affinity coordination of histidine to zinc. In the case of conjugates assembled with biotin-streptavidin no significant interference with the optical and binding properties occurs whereas the histidine-zinc system appears to be affected by human plasma.

  1. Evidence of mass exchange between inside and outside of sonoluminescing bubble in aqueous solution of terbium chloride

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Jinfu, E-mail: liang.shi2007@163.com [School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550001 (China); Chen, Weizhong, E-mail: wzchen@nju.edu.cn [The Key Laboratory of Modern Acoustics, Ministry of Education, Institution of Acoustics, Nanjing University, Nanjing 210093 (China); Wang, Xun; Yang, Jing; Chen, Zhan [The Key Laboratory of Modern Acoustics, Ministry of Education, Institution of Acoustics, Nanjing University, Nanjing 210093 (China)

    2016-12-16

    Highlights: • Time-resolved spectra of SBSL were obtained for Tb{sup 3+} ions emission lines. • Mass exchange between inside and outside of SL bubble was probed via Tb{sup 3+} ions lines. • The argon rectification hypothesis was tested by time-resolved spectra of SBSL. • The rate of mass exchange inside an SBSL bubble increases with increasing sound pressure. - Abstract: Spectra of single-bubble sonoluminescence (SBSL) were obtained for Tb{sup 3+} ions emission lines from bubbles in an aqueous solution of terbium chloride (TbCl{sub 3}). The spectra provide experimental evidence to prove that an air bubble driven by strong ultrasound will not eventually become a rectified pure argon bubble, which is not as predicted by the argon rectification hypothesis. The time-resolved spectra of SBSL show a mass exchange of material such as Tb{sup 3+} ions between the inside and outside of the bubble. With increasing sound pressure, the rate of mass exchange and the SBSL intensity increases.

  2. Optical properties and electrical transport of thin films of terbium(III bis(phthalocyanine on cobalt

    Directory of Open Access Journals (Sweden)

    Peter Robaschik

    2014-11-01

    Full Text Available The optical and electrical properties of terbium(III bis(phthalocyanine (TbPc2 films on cobalt substrates were studied using variable angle spectroscopic ellipsometry (VASE and current sensing atomic force microscopy (cs-AFM. Thin films of TbPc2 with a thickness between 18 nm and 87 nm were prepared by organic molecular beam deposition onto a cobalt layer grown by electron beam evaporation. The molecular orientation of the molecules on the metallic film was estimated from the analysis of the spectroscopic ellipsometry data. A detailed analysis of the AFM topography shows that the TbPc2 films consist of islands which increase in size with the thickness of the organic film. Furthermore, the cs-AFM technique allows local variations of the organic film topography to be correlated with electrical transport properties. Local current mapping as well as local I–V spectroscopy shows that despite the granular structure of the films, the electrical transport is uniform through the organic films on the microscale. The AFM-based electrical measurements allow the local charge carrier mobility of the TbPc2 thin films to be quantified with nanoscale resolution.

  3. Highly luminescent charge-neutral europium(iii) and terbium(iii) complexes with tridentate nitrogen ligands.

    Science.gov (United States)

    Senthil Kumar, Kuppusamy; Schäfer, Bernhard; Lebedkin, Sergei; Karmazin, Lydia; Kappes, Manfred M; Ruben, Mario

    2015-09-21

    We report on the synthesis of tridentate-nitrogen pyrazole-pyridine-tetrazole (L(1)H) and pyrazole-pyridine-triazole (L(2)H) ligands and their complexation with lanthanides (Ln = Gd(iii), Eu(iii) and Tb(iii)) resulting in stable, charge-neutral complexes Ln(L(1))3 and Ln(L(2))3, respectively. X-ray crystallographic analysis of the complexes with L(1) ligands revealed tricapped trigonal coordination geometry around the lanthanide ions. All complexes show bright photoluminescence (PL) in the solid state, indicating efficient sensitization of the lanthanide emission via the triplet states of the ligands. In particular, the terbium complexes show high PL quantum yields of 65 and 59% for L(1) and L(2), respectively. Lower PL efficiencies of the europium complexes (7.5 and 9%, respectively) are attributed to large energy gaps between the triplet states of the ligands and accepting levels of Eu(iii). The triplet state energy can be reduced by introducing an electron withdrawing (EW) group at the 4 position of the pyridine ring. Such substitution of L(1)H with a carboxylic ester (COOMe) EW group leads to a europium complex with increased PL quantum yield of 31%. A comparatively efficient PL of the complexes dissolved in ethanol indicates that the lanthanide ions are shielded against nonradiative deactivation via solvent molecules.

  4. Micelle enhanced and terbium sensitized spectrofluorimetric determination of danofloxacin in milk using molecularly imprinted solid phase extraction

    Science.gov (United States)

    Kaur, Kuldeep; Saini, Shivender Singh; Malik, Ashok Kumar; Singh, Baldev

    2012-10-01

    An efficient molecularly imprinted solid phase extraction (MISPE)-spectrofluorimetric method was developed to sensitively determine danofloxacin (DAN) in milk samples. Solid phase extraction procedure using MISPE cartridges was first performed on milk samples and then spectrofluorimetric determination was done at 546 nm using an excitation wavelength of 285 nm in presence of terbium and sodium dodecyl benzene sulfonate (SDBS). It was found that SDBS significantly enhanced the fluorescence intensity of the DAN-Tb3+ complex. Various factors affecting the fluorescence intensity of DAN-Tb3+-SDBS system were studied and conditions were optimized. The enhanced fluorescence intensity of the system (ΔF) showed a good linear relationship with the concentration of DAN over the range of 8.4 × 10-9-3.4 × 10-7 mol L-1 with a correlation coefficient of 0.9996. The detection limit was determined as 2.0 × 10-9 mol L-1 and the limit of quantification was determined as 6.5 × 10-9 mol L-1. The MISPE-spectrofluorimetric procedure was successfully applied to the determination of DAN in milk samples. The method is simple, rapid, sensitive and allows interference free determination of DAN in complex fluorescent matrices like milk. The method can be used to determine whether the DAN residues in milk exceed MRLs or not.

  5. Study of quantum dot based on tin/yttrium mixed oxide doped with terbium to be used as biomarker

    Energy Technology Data Exchange (ETDEWEB)

    Paganini, Paula P.; Felinto, Maria Claudia F.C.; Kodaira, Claudia A., E-mail: paulapaganini@usp.b, E-mail: mfelinto@ipen.b, E-mail: claudiakodaira@yahoo.co [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Brito, Hermi F., E-mail: hefbrito@iq.usp.b [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Quimica. Lab. de Elementos do Bloco f; Nunes, Luiz Antonio O., E-mail: luizant@ifsc.usp.b [Universidade de Sao Paulo (USP), Sao Carlos, SP (Brazil). Inst. de Fisica. Dept. de Fisica e Informatica

    2009-07-01

    Quantum dots (semiconductors nanocrystals) have brought a promising field to develop a new generation of luminescent biomarkers. The use of lanthanides ions as luminescent markers has many advantages, for example a security method, low cost, high specificity and also the luminescence can be promptly measured with high sensibility and accuracy. These luminescent dots are functionalized with biomolecules. For the luminophore particle to be connect with biologicals molecules (for example covalent antibody) is necessary a previous chemical treatment to modify luminophore particle surface and this process is called functionalization. A prior chemical treatment with changes on the surface luminophore particle is necessary to couple the luminophore to biological molecules. This process can be used as coating which can protect these particles from being dissolved by acid as well as provide functional groups for biological conjugation. This work presents a photoluminescence study of nanoparticles based on tin/yttrium mixed oxides doped with terbium (SnO{sub 2}/Y{sub 2}O{sub 3}:Tb{sup 3+}), synthesized by coprecipitation method. The nanoparticles were submitted to thermal treatment and characterized by X-Ray Powder Diffraction (XRD) that showed cassiterite phase formation and the influence of thermal treatment on nanoparticles structures. These nanoparticles going to be functionalized with a natural polysaccharide (chitosan) in order to form microspheres. These microspheres going to be irradiated with gamma radiation to sterilization and it can be evaluated if the nanoparticles are resistant to irradiation and they do not lose functionality with this process. (author)

  6. 158th Symposium of the International Astronomical Union

    CERN Document Server

    Tango, W

    1994-01-01

    The 1990s are proving to be a very exciting p&iod for high angular resolution astronomy. At radio wavelengths a combination of new array instruments and pow­ erful imaging algorithms have generated images of unprecedented resolution and quality. In the optical and infrared, the great technical difficulties associated with constructing separated-aperture interferometers have been largely overcome, and many new instruments are now operating or are being developed. As these pro­ grams start to produce observational results they will be able to draw extensively on the experience gained by the radio-interferometry community. Thus it seemed that the time was ripe for a meeting which would bring together workers from all wavelength ranges to discuss the details of the science and art of "Very High Angular Resolution Imaging" . While the main emphasis of Symposium No. 158 was on high resolution tech­ niques from the radio, mm-wave, infrared and optical bands, it also provided an opportunity for presentation of...

  7. 40 CFR 158.270 - Experimental use permit data requirements for residue chemistry.

    Science.gov (United States)

    2010-07-01

    ... requirements for residue chemistry. 158.270 Section 158.270 Protection of Environment ENVIRONMENTAL PROTECTION... Experimental use permit data requirements for residue chemistry. All residue chemistry data, as described in... section 408(r) is sought. Residue chemistry data are not required for an experimental use permit issued on...

  8. 40 CFR 158.210 - Experimental use permit data requirements for product chemistry.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Experimental use permit data requirements for product chemistry. 158.210 Section 158.210 Protection of Environment ENVIRONMENTAL PROTECTION... Experimental use permit data requirements for product chemistry. All product chemistry data, as described in...

  9. 40 CFR 158.2140 - Microbial pesticides toxicology data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides toxicology data... pesticides toxicology data requirements table. (a) General. Sections 158.100 through 158.130 describe how to use this table to determine the toxicology data requirements for a particular pesticide product. Notes...

  10. 40 CFR 158.2082 - Experimental use permit biochemical pesticides residue data requirements table.

    Science.gov (United States)

    2010-07-01

    ... biochemical pesticide products when Tier II or Tier III toxicology data are required, as specified for... pesticides residue data requirements table. 158.2082 Section 158.2082 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides...

  11. 17 CFR 1.58 - Gross collection of exchange-set margins.

    Science.gov (United States)

    2010-04-01

    ...-set margins. 1.58 Section 1.58 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION... margins. (a) Each futures commission merchant which carries a commodity futures or commodity option... must deposit, initial and maintenance margin on each position reported in accordance with § 17.04 of...

  12. 78 FR 49254 - Foreign-Trade Zone 158-Vicksburg/Jackson, Mississippi; Authorization of Production Activity...

    Science.gov (United States)

    2013-08-13

    ... Foreign-Trade Zones Board Foreign-Trade Zone 158--Vicksburg/Jackson, Mississippi; Authorization of Production Activity; Extension of Production Authority; Bauhaus USA, Inc. (Upholstered Furniture); Saltillo, Mississippi On February 28, 2013, the Greater Mississippi Foreign-Trade Zone, Inc., grantee of FTZ 158...

  13. Terbium-doped gadolinium oxysulfide (Gd2O2S:Tb) scintillation-based polymer optical fibre sensor for real time monitoring of radiation dose in oncology

    Science.gov (United States)

    Lewis, E.; O'Keeffe, S.; Grattan, M.; Hounsell, A.; McCarthy, D.; Woulfe, P.; Cronin, J.; Mihai, L.; Sporea, D.; Santhanam, A.; Agazaryan, N.

    2014-05-01

    A PMMA based plastic optical fibre sensor for use in real time radiotherapy dosimetry is presented. The optical fibre tip is coated with a scintillation material, terbium-doped gadolinium oxysulfide (Gd2O2S:Tb), which fluoresces when exposed to ionising radiation (X-Ray). The emitted visible light signal penetrates the sensor optical fibre and propagates along the transmitting fibre at the end of which it is remotely monitored using a fluorescence spectrometer. The results demonstrate good repeatability, with a maximum percentage error of 0.5% and the response is independent of dose rate.

  14. Over-expression of miR158 causes pollen abortion in Brassica campestris ssp. chinensis.

    Science.gov (United States)

    Ma, Zhiming; Jiang, Jianxia; Hu, Ziwei; Lyu, Tianqi; Yang, Yang; Jiang, Jingjing; Cao, Jiashu

    2017-02-01

    We identified and cloned the two precursors of miR158 and its target gene in Brassica campestris ssp. chinensis, which both had high relative expression in the inflorescences. Further study revealed that over-expression of miR158 caused reduced pollen varbility, which was caused by the degradation of pollen contents from the binucleate microspore stage. These results first suggest the role of miR158 in pollen development of Brassica campestris ssp. chinensis. MicroRNAs (miRNAs) play crucial roles in many important growth and development processes both in plants and animals by regulating the expression of their target genes via mRNA cleavage or translational repression. In this study, miR158, a Brassicaceae specific miRNA, was functionally characterized with regard to its role in pollen development of non-heading Chinese cabbage (Brassica campestris ssp. chinensis). Two family members of miR158 in B. campestris, namely bra-miR158a1 and bra-miR158a2, and their target gene bra027656, which encodes a pentatricopeptide repeat (PPR) containing protein, were identified. Then, qRT-PCR analysis and GUS-reporter system revealed that both bra-miR158 and its target gene had relatively high expression levels in the inflorescences. Further study revealed that over-expression of miR158 caused reduced pollen varbility and pollen germination ratio, and the degradation of pollen contents from the binucleate microspore stage was also found in those deformed pollen grains, which led to pollen shrinking and collapse in later pollen development stage. These results first shed light on the importance of miR158 in pollen development of Brassica campestris ssp. chinensis.

  15. COMT Val158Met Polymorphism Modulates Huntington's Disease Progression

    Science.gov (United States)

    Rebeix, Isabelle; Dupoux, Emmanuel; Durr, Alexandra; Brice, Alexis; Charles, Perrine; Cleret de Langavant, Laurent; Youssov, Katia; Verny, Christophe; Damotte, Vincent; Azulay, Jean-Philippe; Goizet, Cyril; Simonin, Clémence; Tranchant, Christine; Maison, Patrick; Rialland, Amandine; Schmitz, David; Jacquemot, Charlotte; Fontaine, Bertrand; Bachoud-Lévi, Anne-Catherine

    2016-01-01

    Little is known about the genetic factors modulating the progression of Huntington’s disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, which influences dopamine (DA) degradation, affects clinical progression in HD. We carried out a prospective longitudinal multicenter study from 1994 to 2011, on 438 HD gene carriers at different stages of the disease (34 pre-manifest; 172 stage 1; 130 stage 2; 80 stage 3; 17 stage 4; and 5 stage 5), according to Total Functional Capacity (TFC) score. We used the Unified Huntington’s Disease Rating Scale to evaluate motor, cognitive, behavioral and functional decline. We genotyped participants for COMT polymorphism (107 Met-homozygous, 114 Val-homozygous and 217 heterozygous). 367 controls of similar ancestry were also genotyped. We compared clinical progression, on each domain, between groups of COMT polymorphisms, using latent-class mixed models accounting for disease duration and number of CAG (cytosine adenine guanine) repeats. We show that HD gene carriers with fewer CAG repeats and with the Val allele in COMT polymorphism displayed slower cognitive decline. The rate of cognitive decline was greater for Met/Met homozygotes, which displayed a better maintenance of cognitive capacity in earlier stages of the disease, but had a worse performance than Val allele carriers later on. COMT polymorphism did not significantly impact functional and behavioral performance. Since COMT polymorphism influences progression in HD, it could be used for stratification in future clinical trials. Moreover, DA treatments based on the specific COMT polymorphism and adapted according to disease duration could potentially slow HD progression. PMID:27657697

  16. Vertebrados silvestres atropelados na BR 158, RS, Brasil

    Directory of Open Access Journals (Sweden)

    Daniela da Silva Oliveira

    2012-09-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2012v25n4p229   Entre os problemas que ameaçam a fauna silvestre, o atropelamento de animais é uma importante causa de mortalidade para várias espécies. O presente estudo visou identificar as espécies vitimadas por atropelamento em 98km da rodovia BR 158, entre o município de Cruz Alta e o distrito de Val de Serra, município de Júlio de Castilhos, RS e analisar as variações mensais nas taxas de atropelamento e sua correlação com o volume mensal de chuvas. Foram realizadas expedições mensais, entre os meses de abril a setembro de 2007, onde se registrou 61 animais atropelados pertencentes a 15 espécies, com uma taxa de atropelamento de 0,10 ind./km/mês. As espécies com maior número de atropelamentos foram o zorrilho (Conepatus chinga, com 17 indivíduos (28%, seguida pelo graxaim-do-campo (Lycalopex gymnocercus, com sete (11% e o graxaim-do-mato (Cerdocyon thous, com cinco (8%. Não foi encontrada diferença nas taxas de atropelamento entre os meses amostrados, contudo, o mês com maior registro de atropelamentos foi setembro (n=18. Também não foi verificada correlação entre os atropelamentos e a precipitação mensal, no entanto, há uma tendência entre a ocorrência dos atropelamentos com um volume maior de chuvas.

  17. Compact all-fiber optical Faraday components using 65-wt%-terbium-doped fiber with a record Verdet constant of -32 rad/(Tm).

    Science.gov (United States)

    Sun, L; Jiang, S; Marciante, J R

    2010-06-07

    A compact all-fiber Faraday isolator and a Faraday mirror are demonstrated. At the core of each of these components is an all-fiber Faraday rotator made of a 4-cm-long, 65-wt%-terbium-doped silicate fiber. The effective Verdet constant of the terbium-doped fiber is measured to be -32 rad/(Tm), which is 27 x larger than that of silica fiber. This effective Verdet constant is the largest value measured to date in any fiber and is 83% of the Verdet constant of commercially available crystal used in bulk optics-based isolators. Combining the all-fiber Faraday rotator with fiber polarizers results in a fully fusion spliced all-fiber isolator whose isolation is measured to be 19 dB. Combining the all-fiber Faraday rotator with a fiber Bragg grating results in an all-fiber Faraday mirror that rotates the polarization state of the reflected light by 88 +/- 4 degrees .

  18. Picomolar Traces of Americium(III) Introduce Drastic Changes in the Structural Chemistry of Terbium(III): A Break in the "Gadolinium Break".

    Science.gov (United States)

    Welch, Jan M; Müller, Danny; Knoll, Christian; Wilkovitsch, Martin; Giester, Gerald; Ofner, Johannes; Lendl, Bernhard; Weinberger, Peter; Steinhauser, Georg

    2017-10-16

    The crystallization of terbium 5,5'-azobis[1H-tetrazol-1-ide] (ZT) in the presence of trace amounts (ca. 50 Bq, ca. 1.6 pmol) of americium results in 1) the accumulation of the americium tracer in the crystalline solid and 2) a material that adopts a different crystal structure to that formed in the absence of americium. Americium-doped [Tb(Am)(H 2 O) 7 ZT] 2 ZT⋅10 H 2 O is isostructural to light lanthanide (Ce-Gd) 5,5'-azobis[1H-tetrazol-1-ide] compounds, rather than to the heavy lanthanide (Tb-Lu) 5,5'-azobis[1H-tetrazol-1-ide] (e.g., [Tb(H 2 O) 8 ] 2 ZT 3 ⋅6 H 2 O) derivatives. Traces of Am seem to force the Tb compound into a structure normally preferred by the lighter lanthanides, despite a 10 8 -fold Tb excess. The americium-doped material was studied by single-crystal X-ray diffraction, vibrational spectroscopy, radiochemical neutron activation analysis, and scanning electron microcopy. In addition, the inclusion properties of terbium 5,5'-azobis[1H-tetrazol-1-ide] towards americium were quantified, and a model for the crystallization process is proposed. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Uncertainty of determination of158Tb in the RBMK nuclear reactor waste.

    Science.gov (United States)

    Plukis, Artūras; Barkauskas, Vytenis; Druteikienė, Rūta; Duškesas, Grigorijus; Germanas, Darius; Gudelis, Arūnas; Juodis, Laurynas; Lagzdina, Elena; Plukienė, Rita; Remeikis, Vidmantas

    2017-08-03

    The activity of 158 Tb was measured in waste samples from the Ignalina NPP Unit I RBMK-1500 reactor using gamma-ray spectrometry. The origin of 158 Tb and the other observed gamma-ray emitters has been studied by using SCALE 6.1 modeling and comparing radionuclide ratios in the RBMK-1500 radioactive waste. The results of the calculation of the massic activity of gamma-ray emitters were used for interpretation of the total gamma-ray spectrum and the determination of 158 Tb massic activity uncertainty in the waste of RBMK-1500. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Posterior fossa imaging in 158 children with ataxia.

    Science.gov (United States)

    Boddaert, N; Desguerre, I; Bahi-Buisson, N; Romano, S; Valayannopoulos, V; Saillour, Y; Seidenwurm, D; Grevent, D; Berteloot, L; Lebre, A-S; Zilbovicius, M; Puget, S; Salomon, R; Attie-Bitach, T; Munnich, A; Brunelle, F; de Lonlay, P

    2010-10-01

    To propose a MRI cerebellar algorithm that may be applied to guide genetic/malformative or biochemical investigations for patients with cerebellar ataxia. Cerebral MRI of 158 patients with cerebellar ataxia and no supratentorial abnormality were examined according to a new categorization system based on posterior fossa imaging. The clinical and radiological findings were confronted to biochemical and/or genetic results using the MR cerebellar algorithm. Seven groups of cerebellar MRI pattern were described: vermian dysgenesis (n=27), cerebellar hypoplasia (n=15), hemispheric cerebellar dysgenesis (n=6), unilateral hemispheric atrophy (n=5), global cerebellar atrophy (n=84), signal abnormalities (n=11) and normal MRI (n=10). Cerebellar hypoplasia, vermian dysgenesis and hemispheric cerebellar dysgenesis groups were classified as malformative disorders. Global atrophy and signal abnormality groups were classified as metabolic disorders. In the vermian dysgenesis group, a specific genetic diagnosis was obtained in eight children (8/27) and all of the mutated genes (AHI1 (JBS3), CEP290 (JBS5), TMEM67 (JBS6), and RPGRIP1L (JBS7)) are involved in primary cilia function. In the group of pontocerebellar hypoplasia specific genetic diagnosis was obtained in one patient (PCH2) (1/15). Thus, nine of 42 children classified as malformative disorder had a molecular diagnosis. Global atrophy and signal abnormality groups were classified as metabolic disorders, specific biochemical was obtained in 46/95 children. In global atrophy group, respiratory chain deficiency was diagnosed in 18 children (18/84). In 21 children a congenital disorders of glycosylation type 1a (CDG Ia) was diagnosed (21/84) and infantile neuroaxonale dystrophy (INAD) was diagnosed in one child. In signal abnormalities group, specific biochemical diagnosis was obtained in six out of 11 children, five children with respiratory chain deficiency and one child with sulphite oxidase deficiency. In hemispheric

  1. Yeast Interacting Proteins Database: YOR158W, YLR424W [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YOR158W PET123 Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions...al ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a

  2. Fragmentation studies of 158 A GeV Pb ions using CR39 nuclear track detectors

    CERN Document Server

    Dekhissi, H; Giorgini, M; Mandrioli, G; Manzoor, S; Patrizii, L; Popa, V; Serra, P; Togo, V

    2000-01-01

    Six stacks of CR39 nuclear track detectors with different targets were exposed to a lead ion beam of 158 A GeV at the CERN-SPS, at normal incidence, in order to study the fragmentation properties of ultra-relativistic lead nuclei. Measurements of the total, break-up and pick-up charge-changing cross sections of 158 A GeV Pb ions have been made for the first time.

  3. COMT val158met genotype affects recruitment of neural mechanisms supporting fluid intelligence.

    Science.gov (United States)

    Bishop, Sonia J; Fossella, John; Croucher, Camilla J; Duncan, John

    2008-09-01

    Fluid intelligence (g(f)) influences performance across many cognitive domains. It is affected by both genetic and environmental factors. Tasks tapping g(f) activate a network of brain regions including the lateral prefrontal cortex (LPFC), the presupplementary motor area/anterior cingulate cortex (pre-SMA/ACC), and the intraparietal sulcus (IPS). In line with the "intermediate phenotype" approach, we assessed effects of a polymorphism (val(158)met) in the catechol-O-methyltransferase (COMT) gene on activity within this network and on actual task performance during spatial and verbal g(f) tasks. COMT regulates catecholaminergic signaling in prefrontal cortex. The val(158) allele is associated with higher COMT activity than the met(158) allele. Twenty-two volunteers genotyped for the COMT val(158)met polymorphism completed high and low g(f) versions of spatial and verbal problem-solving tasks. Our results showed a positive effect of COMT val allele load upon the blood oxygen level-dependent response in LPFC, pre-SMA/ACC, and IPS during high g(f) versus low g(f) task performance in both spatial and verbal domains. These results indicate an influence of the COMT val(158)met polymorphism upon the neural circuitry supporting g(f). The behavioral effects of val allele load differed inside and outside the scanner, consistent with contextual modulation of the relation between COMT val(158)met genotype and g(f) task performance.

  4. Crystal structures of two mononuclear complexes of terbium(III) nitrate with the tripodal alcohol 1,1,1-tris-(hy-droxy-meth-yl)propane.

    Science.gov (United States)

    Gregório, Thaiane; Giese, Siddhartha O K; Nunes, Giovana G; Soares, Jaísa F; Hughes, David L

    2017-02-01

    Two new mononuclear cationic complexes in which the TbIII ion is bis-chelated by the tripodal alcohol 1,1,1-tris-(hy-droxy-meth-yl)propane (H3LEt, C6H14O3) were prepared from Tb(NO3)3·5H2O and had their crystal and mol-ecular structures solved by single-crystal X-ray diffraction analysis after data collection at 100 K. Both products were isolated in reasonable yields from the same reaction mixture by using different crystallization conditions. The higher-symmetry complex dinitratobis[1,1,1-tris-(hy-droxy-meth-yl)propane]-terbium(III) nitrate di-meth-oxy-ethane hemisolvate, [Tb(NO3)2(H3LEt)2]NO3·0.5C4H10O2, 1, in which the lanthanide ion is 10-coordinate and adopts an s-bicapped square-anti-prismatic coordination geometry, contains two bidentate nitrate ions bound to the metal atom; another nitrate ion functions as a counter-ion and a half-mol-ecule of di-meth-oxy-ethane (completed by a crystallographic twofold rotation axis) is also present. In product aqua-nitratobis[1,1,1-tris-(hy-droxy-meth-yl)propane]-terbium(III) dinitrate, [Tb(NO3)(H3LEt)2(H2O)](NO3)2, 2, one bidentate nitrate ion and one water mol-ecule are bound to the nine-coordinate terbium(III) centre, while two free nitrate ions contribute to charge balance outside the tricapped trigonal-prismatic coordination polyhedron. No free water mol-ecule was found in either of the crystal structures and, only in the case of 1, di-meth-oxy-ethane acts as a crystallizing solvent. In both mol-ecular structures, the two tripodal ligands are bent to one side of the coordination sphere, leaving room for the anionic and water ligands. In complex 2, the methyl group of one of the H3LEt ligands is disordered over two alternative orientations. Strong hydrogen bonds, both intra- and inter-molecular, are found in the crystal structures due to the number of different donor and acceptor groups present.

  5. The response behavior of PPy-DB18C6 electrode to terbium(III in acetonitrile and its thermodynamic application

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Arbab Zavar

    2016-11-01

    Full Text Available Polypyrrole modified electrode prepared by electropolymerization of pyrrole in the presence of a complexing ligand, dibenzo-18-crown-6(DB18C6, was prepared and investigated as a Tb3+-selective electrode in acetonitrile. The potentiometric response of the electrode was linear within the Tb3+ concentration range 1 × 10−5–1 × 10−2 M with a Nernstian slope of 20.9 mVdecade−1 in AN. The electrode was applied to study the complexation of the terbium(III ion in acetonitrile with such other basic aprotic solvent molecules (D as dimethyl sulfoxide, N,N-dimethyl formamide, propylene carbonate and pyridine. The successive complex formation constant (βi and Gibbs energies of transfer (ΔGtr of Tb3+ in AN in relation to such D were obtained.

  6. Luminescence and Magnetic Properties of Two Three-Dimensional Terbium and Dysprosium MOFs Based on Azobenzene-4,4′-Dicarboxylic Linker

    Directory of Open Access Journals (Sweden)

    Belén Fernández

    2016-02-01

    Full Text Available We report the in situ formation of two novel metal-organic frameworks based on terbium and dysprosium ions using azobenzene-4,4′-dicarboxylic acid (H2abd as ligand, synthesized by soft hydrothermal routes. Both materials show isostructural three-dimensional networks with channels along a axis and display intense photoluminescence properties in the solid state at room temperature. Textural properties of the metal-organic frameworks (MOFs have been fully characterized although no appreciable porosity was obtained. Magnetic properties of these materials were studied, highlighting the dysprosium material displays slightly frequency-dependent out of phase signals when measured under zero external field and under an applied field of 1000 Oe.

  7. Luminescent europium and terbium complexes of dipyridoquinoxaline and dipyridophenazine ligands as photosensitizing antennae: structures and biological perspectives.

    Science.gov (United States)

    Dasari, Srikanth; Patra, Ashis K

    2015-12-14

    The europium(III) and terbium(III) complexes, namely [Eu(dpq)(DMF)2(NO3)3] (1), [Eu(dppz)2(NO3)3] (2), [Tb(dpq)(DMF)2Cl3] (3), and [Tb(dppz)(DMF)2Cl3] (4), where dipyrido[3,2-d:2',3'-f]quinoxaline (dpq in 1 and 3), dipyrido[3,2-a:2',3'-c]phenazine (dppz in 2 and 4) and N,N'-dimethylformamide (DMF) have been isolated, characterized from their physicochemical data, luminescence studies and their interaction with DNA, serum albumin protein and photo-induced DNA cleavage activity are studied. The X-ray crystal structures of complexes 1-4 show discrete mononuclear Ln(3+)-based structures. The Eu(3+) in [Eu(dpq)(DMF)2(NO3)3] (1) and [Eu(dppz)2(NO3)3] (2) as [Eu(dppz)2(NO3)3]·dppz (2a) adopts a ten-coordinated bicapped dodecahedron structure with a bidentate N,N-donor dpq ligand, two DMF and three NO3(-) anions in 1 and two bidentate N,N-donor dppz ligands and three NO3(-) anions in 2. Complexes 3 and 4 show a seven-coordinated mono-capped octahedron structure where Tb(3+) contains bidentate dpq/dppz ligands, two DMF and three Cl(-) anions. The complexes are highly luminescent in nature indicating efficient photo-excited energy transfer from the dpq/dppz antenna to Ln(3+) to generate long-lived emissive excited states for characteristic f → f transitions. The time-resolved luminescence spectra of complexes 1-4 show typical narrow emission bands attributed to the (5)D0 → (7)F(J) and (5)D4 → (7)F(J) f-f transitions of Eu(3+) and Tb(3+) ions respectively. The number of inner-sphere water molecules (q) was determined from luminescence lifetime measurements in H2O and D2O confirming ligand-exchange reactions with water in solution. The complexes display significant binding propensity to the CT-DNA giving binding constant values in the range of 1.0 × 10(4)-6.1 × 10(4) M(-1) in the order 2, 4 (dppz) > 1, 3 (dpq). DNA binding data suggest DNA groove binding with the partial intercalation nature of the complexes. All the complexes also show binding propensity (K(BSA)

  8. TERMINATION OF EMPLOYMENT: A CASE STUDY OF TURKISH LABOUR LAW TO COMPARE ILO CONVENTION NO. 158

    Directory of Open Access Journals (Sweden)

    PİR ALİ KAYA

    2013-05-01

    Full Text Available Today, employment security is a most important need for wage-earners, especially in developing countries which have a high rate of unemployment, where firing workers is a way to lower wages. Because of that there are some provisions of international regulations that need to be addressed. Job security and restrictions on firing figure prominently in much national labour legislation. These provisions and principles are underlined in ILO Recommendation No. 119 and Convention No. 158. In this paper, attention is focused on ILO Convention No. 158 and its repercussions on Turkish labour law.

  9. Spin Waves in Terbium

    DEFF Research Database (Denmark)

    Jensen, J.; Houmann, Jens Christian Gylden

    1975-01-01

    The selection rules for the linear couplings between magnons and phonons propagating in the c direction of a simple basal-plane hcp ferromagnet are determined by general symmetry considerations. The acoustic-optical magnon-phonon interactions observed in the heavy-rare-earth metals have been expl...... by Liu. The coupled magnon—transverse-phonon system for the c direction of Tb is analyzed in detail, and the strengths of the couplings are deduced as a function of wave vector by combining the experimental studies with the theory....

  10. Spin Waves in Terbium

    DEFF Research Database (Denmark)

    Jensen, J.; Houmann, Jens Christian Gylden; Bjerrum Møller, Hans

    1975-01-01

    The energies of spin waves propagating in the c direction of Tb have been studied by inelastic neutron scattering, as a function of a magnetic field applied along the easy and hard directions in the basal plane, and as a function of temperature. From a general spin Hamiltonian, consistent...... with the symmetry, we deduce the dispersion relation for the spin waves in a basal-plane ferromagnet. This phenomenological spin-wave theory accounts for the observed behavior of the magnon energies in Tb. The two q⃗-dependent Bogoliubov components of the magnon energies are derived from the experimental results...

  11. 40 CFR 158.2030 - Biochemical pesticides product chemistry data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Biochemical pesticides product... PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2030 Biochemical pesticides product chemistry data requirements table. (a) General. (1) Sections...

  12. 40 CFR 158.2070 - Biochemical pesticides product performance data requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Biochemical pesticides product... AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2070 Biochemical pesticides product performance data requirements. Product performance data must be developed for...

  13. 40 CFR 158.2050 - Biochemical pesticides human health assessment data requirements table.

    Science.gov (United States)

    2010-07-01

    ... § 158.2050 Biochemical pesticides human health assessment data requirements table. (a) General. (1... table shows the data requirements for biochemical pesticides human health assessment. The test notes are shown in paragraph (e) of this section. Table—Biochemical Pesticides Human Health Assessment Data...

  14. 40 CFR 158.660 - Nontarget plant protection data requirements table.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Ecological Effects § 158.660 Nontarget plant... required for contained pesticide treatments such as bait boxes and pheromone traps unless adverse effects... table to determine the nontarget plant data requirements for a particular pesticide product. Notes that...

  15. 42 CFR 483.158 - FFP for nurse aide training and competency evaluation.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false FFP for nurse aide training and competency... CARE FACILITIES Requirements That Must Be Met by States and State Agencies: Nurse Aide Training and Competency Evaluation, and Paid Feeding Assistants § 483.158 FFP for nurse aide training and competency...

  16. Yeast Interacting Proteins Database: YOR158W, YLR423C [Yeast Interacting Proteins Database

    Lifescience Database Archive (English)

    Full Text Available YOR158W PET123 Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions...23 Bait description Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interact...ions with PET122, which encodes a COX3 mRNA-specific translational activator Rows w

  17. 40 CFR 158.2160 - Microbial pesticides product performance data requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Microbial pesticides product... AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Microbial Pesticides § 158.2160 Microbial pesticides product performance data requirements. Product performance data must be developed for...

  18. The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.

    NARCIS (Netherlands)

    Rowe, J.B.; Hughes, L.; Williams-Gray, C.H.; Bishop, S.; Fallon, S.J.; Barker, R.A.; Owen, A.M.

    2010-01-01

    We investigated whether the val(158)met functional polymorphism of catechol-o-methyltransferase influenced age-related changes in grey matter density and volume, both in healthy individuals (n=80, ages 18-79) and those with Parkinson's disease (n=50). Global grey matter volumes and voxelwise

  19. COMT Val158Met polymorphism, verbalizing of emotion and activation of affective brain systems

    NARCIS (Netherlands)

    Swart, Marte; Bruggeman, Richard; Laroi, Frank; Alizadeh, Behrooz Z.; Kema, Ido; Kortekaas, Rudie; Wiersma, Durk; Aleman, Andre

    2011-01-01

    Genetic variation in the catechol-O-methyltransferase (COMT) Val158Met polymorphism has been shown to influence performance on cognitive and emotional tasks. Specifically, it has been suggested that the Met allele might be less advantageous than the Val allele with respect to emotional processing.

  20. 40 CFR 158.2040 - Biochemical pesticides residue data requirements table.

    Science.gov (United States)

    2010-07-01

    ... to biochemical pesticide products when Tier II or Tier III toxicology data are required, as specified... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Biochemical pesticides residue data... (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2040 Biochemical...

  1. 75 FR 79335 - Foreign-Trade Zone 158-Vicksburg/Jackson, MI, Application for Expansion

    Science.gov (United States)

    2010-12-20

    ... Foreign-Trade Zones Board Foreign-Trade Zone 158--Vicksburg/Jackson, MI, Application for Expansion An application has been submitted to the Foreign-Trade Zones Board (the Board) by the Greater Mississippi Foreign..., Mississippi. The application was submitted pursuant to the provisions of the Foreign-Trade Zones Act, as...

  2. 77 FR 65359 - Expansion of Foreign-Trade Zone 158; Vicksburg/Jackson, MS

    Science.gov (United States)

    2012-10-26

    ... Foreign-Trade Zones Board Expansion of Foreign-Trade Zone 158; Vicksburg/Jackson, MS Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the Foreign-Trade Zones Board (the Board) adopts the following Order: ] Whereas, the Greater Mississippi Foreign...

  3. 78 FR 33340 - Expansion of Foreign-Trade Zone 158; Vicksburg/Jackson, Mississippi

    Science.gov (United States)

    2013-06-04

    ... Foreign-Trade Zones Board Expansion of Foreign-Trade Zone 158; Vicksburg/Jackson, Mississippi Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u), the Foreign-Trade Zones Board (the Board) adopts the following Order: Whereas, the Greater Mississippi Foreign...

  4. 75 FR 17823 - Notice-Interpretation of 49 CFR 158.45

    Science.gov (United States)

    2010-04-07

    ... note that under 49 U.S.C. Section 40117(g) and 14 CFR Section 158.49(b), an air carrier or its agent... the fee, and neither the carrier nor its agent holds legal or equitable interest in the revenues (with... International Airport (SMF) San Francisco International Airport (SFO) John Wayne-Orange County Airport (SNA...

  5. 77 FR 19002 - Foreign-Trade Zone 158-Vicksburg/Jackson, MS; Application for Expansion

    Science.gov (United States)

    2012-03-29

    ... interchange south of the City of Verona. (An expansion application is currently pending (Doc. 70-2010) to... Zone 158--Vicksburg/Jackson, MS; Application for Expansion An application has been submitted to the... located adjacent to U.S. Highway 45 and the Kansas City Southern Railroad and South Green Street, Tupelo...

  6. 42 CFR 422.158 - Procedures for approval of accreditation as a basis for deeming compliance.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Quality Improvement § 422.158 Procedures for approval of accreditation as a basis for deeming compliance. (a) Required... to furnish CMS with electronic data in CMS compatible format. (2) A resource analysis that...

  7. 40 CFR 158.1010 - Applicator exposure-criteria for testing.

    Science.gov (United States)

    2010-07-01

    ...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Human Exposure § 158.1010 Applicator exposure—criteria... adverse effects have been observed in any applicable toxicity study. (2) Scientifically sound epidemiological or poisoning incident data indicate that adverse health effects may have resulted from handling of...

  8. 40 CFR 158.1060 - Post-application exposure-criteria for testing

    Science.gov (United States)

    2010-07-01

    ...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Human Exposure § 158.1060 Post-application exposure... this section. (a) Toxicity criteria. (1) Evidence of potentially significant adverse health effects... poisoning incident data indicate that adverse health effects may have resulted from post-application...

  9. COMT Val158Met Genotype as a Risk Factor for Problem Behaviors in Youth

    Science.gov (United States)

    Albaugh, Matthew D.; Harder, Valerie S.; Althoff, Robert R.; Rettew, David C.; Ehli, Erik A.; Lengyel-Nelson, Timea; Davies, Gareth E.; Ayer, Lynsay; Sulman, Julie; Stanger, Catherine; Hudziak, James J.

    2010-01-01

    Objective: To test the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and both aggressive behavior and attention problems in youth. We hypothesized that youth carrying a Met allele would have greater average aggressive behavior scores, and that youth exhibiting Val-homozygosity would have greater average…

  10. COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia

    DEFF Research Database (Denmark)

    Haraldsson, H Magnus; Ettinger, Ulrich; Magnusdottir, Brynja B

    2009-01-01

    The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls...

  11. Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease

    NARCIS (Netherlands)

    De Lau, L.M.L.; Verbaan, D.; Marinus, J.; Heutink, P.; van Hilten, J.J.

    2012-01-01

    Background:: The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods:: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations.

  12. Analysis of the Association between Catechol-O-Methyltransferase Val158Met and Male Sexual Orientation.

    Science.gov (United States)

    Yu, Wei; Tu, Dan; Hong, Fuchang; Wang, Jing; Liu, Xiaoli; Cai, Yumao; Xu, Ruiwei; Zhao, Guanglu; Wang, Feng; Pan, Hong; Wu, Shinan; Feng, Tiejian; Wang, Binbin

    2015-09-01

    Male sexual orientation is thought to have a genetic component. However, previous studies have failed to generate positive results from among candidate genes. Catechol-O-methyltransferase (COMT), located on chromosome 22, has six exons, spans 27 kb, and encodes a protein of 271 amino acids. COMT has an important role in regulating the embryonic levels of catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine) and estrogens. COMT is also thought to be related to sexual orientation. This study aimed to investigate the relationship between the COMT Val158Met variant and male sexual orientation. We performed association analysis of the COMT gene single nucleotide polymorphism, Val158Met, in 409 homosexual cases and 387 heterosexual control Chinese men. COMT polymorphism status was determined using a polymerase chain reaction-based assay. Polymerase chain reaction was performed to genotype the COMT Val158Met polymorphism. The frequency differences of the genotype and alleles distribution between the male homosexual and control groups. Significant differences, both in genotype and alleles, between male homosexual individuals and controls indicated a genetic component related to male homosexuality. The Val allele recessive model could be an interrelated genetic model of the cause of male homosexuality. The COMT Val158Met variant might be associated with male sexual orientation and a recessive model was suggested. © 2015 International Society for Sexual Medicine.

  13. Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses.

    Directory of Open Access Journals (Sweden)

    Laura Wendt

    Full Text Available A large number of unwanted adverse events and symptoms reported by patients in clinical trials are not caused by the drug provided, since most of adverse events also occur in corresponding placebo groups. These nocebo effects also play a major role in drug discontinuation in clinical practice, negatively affecting treatment efficacy as well as patient adherence and compliance. Experimental and clinical data document a large interindividual variability in nocebo responses, however, data on psychological, biological or genetic predictors of nocebo responses are lacking. Thus, with an established paradigm of behaviorally conditioned immunosuppressive effects we analyzed possible genetic predictors for nocebo responses. We focused on the genetic polymorphisms in the catechol-O-methyltransferase (COMT gene (Val158Met and analyzed drug specific and general side effects before and after immunosuppressive medication and subsequent placebo intake in 62 healthy male subjects. Significantly more drug-specific as well as general side effects were reported from homozygous carriers of the Val158 variant during medication as well as placebo treatment compared to the other genotype groups. Val158/Val158 carriers also had significantly higher scores in the somatosensory amplification scale (SSAS and the BMQ (beliefs about medicine questionnaire. Together these data demonstrate potential genetic and psychological variables predicting nocebo responses after drug and placebo intake, which might be utilized to minimize nocebo effects in clinical trials and medical practice.

  14. 37 CFR 1.58 - Chemical and mathematical formulae and tables.

    Science.gov (United States)

    2010-07-01

    ... Provisions The Application § 1.58 Chemical and mathematical formulae and tables. (a) The specification... order to preserve their intended meaning. (c) Chemical and mathematical formulae and tables must be presented in compliance with § 1.52(a) and (b), except that chemical and mathematical formulae or tables may...

  15. $\\psi^'$ production in Pb-Pb collisions at 158 GeV/nucleon

    CERN Document Server

    Alessandro, B.; Arnaldi, R.; Atayan, M.; Beole, S.; Boldea, V.; Bordalo, P.; Borges, G.; Castor, J.; Chaurand, B.; Cheynis, B.; Chiavassa, E.; Cicalo, C.; Comets, M.P.; Constantinescu, S.; Cortese, P.; De Falco, A.; De Marco, N.; Dellacasa, G.; Devaux, A.; Dita, S.; Drapier, O.; Fargeix, J.; Force, P.; Gallio, M.; Gerschel, C.; Giubellino, P.; Golubeva, M.B.; Gonin, M.; Grigoryan, A.; Grossiord, J.Y.; Guber, F.F.; Guichard, A.; Gulkanyan, H.; Idzik, M.; Jouan, D.; Karavicheva, T.L.; Kluberg, L.; Kurepin, A.B.; Bornec, Y.Le; Lourenco, C.; Cormick, M.Mac; Marzari-Chiesa, A.; Masera, M.; Masoni, A.; Monteno, M.; Musso, A.; Petiau, P.; Piccotti, A.; Pizzi, J.R.; Prino, F.; Puddu, G.; Quintans, C.; Ramello, L.; Ramos, S.; Riccati, L.; Romana, A.; Santos, H.; Saturnini, P.; Scomparin, E.; Serci, S.; Shahoyan, R.; Sitta, M.; Sonderegger, P.; Tarrago, X.; Topilskaya, N.S.; Usai, G.L.; Vercellin, E.; Villatte, L.; Willis, N.

    2007-01-01

    \\psi^' production is studied in Pb-Pb collisions at 158 GeV/c per nucleon incident momentum. Absolute cross-sections are measured and production rates are investigated as a function of the centrality of the collision. The results are compared with those obtained for lighter colliding systems and also for the J/\\psi meson produced under identical conditions.

  16. 75 FR 82372 - Foreign-Trade Zone 158-Vicksburg/Jackson, MS; Application for Expansion

    Science.gov (United States)

    2010-12-30

    ... agency #0;statements of organization and functions are examples of documents #0;appearing in this section...; ] DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 158--Vicksburg/Jackson, MS; Application for Expansion Correction In notice document 2010-31877 beginning on page 79335 in the issue of Monday...

  17. Charged particle production in the Pb + Pb system at 158 GeV/c per nucleon

    CERN Document Server

    Deines-Jones, P.; Dabrowska, A.; Holynski, R.; Kudzia, D.; Nilsen, B.S.; Olszewski, A.; Szarska, M.; Trzupek, A.; Waddington, C.Jake; Wefel, J.P.; Wilczynska, B.; Wilczynski, H.; Wolter, W.; Wosiek, B.; Wozniak, K.

    2000-01-01

    Charged particle multiplicities from high multiplicity central interactions of 158 GeV/nucleon Pb ions with Pb target nuclei have been measured in the central and far forward projectile spectator regions using emulsion chambers. Multiplicities are significantly lower than predicted by Monte Carlo simulations. We examine the shape of the pseudorapidity distribution and its dependence on centrality in detail.

  18. 40 CFR 158.2060 - Biochemical pesticides nontarget organisms and environmental fate data requirements table.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Biochemical pesticides nontarget... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Biochemical Pesticides § 158.2060 Biochemical pesticides nontarget organisms and environmental fate data...

  19. Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson's disease.

    Science.gov (United States)

    Zhang, Youwen; Feng, Shujun; Nie, Kun; Zhao, Xin; Gan, Rong; Wang, Limin; Zhao, Jiehao; Tang, Hongmei; Gao, Liang; Zhu, Ruiming; Wang, Lijuan; Zhang, Yuhu

    2016-10-15

    The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been proposed to be associated with increased risk of Parkinson's disease (PD) and have a specific impact on dopamine-mediated prefrontal executive function in an inverted-U curve manner. We explored the influence of this genetic polymorphism on prefrontal executive function in a well-established Chinese cohort of early PD patients with no current or past history of motor fluctuations or dyskinesias. Cognitive functions were assessed in 250 patients with early PD using Wechsler Adult Intelligence Scale-Chinese Revision (WAIS-RC) and Wechsler Memory Scale-Chinese Revision (WMS-RC). These patients and 300 healthy controls were subsequently genotyped for the COMT gene Val158Met polymorphism. We employed analysis of covariance (ANCOVA) and a stratified analysis to determine the associations between the COMT Val158Met genotype and cognitive functions. The COMT Val158Met allele frequency and genotype distributions showed no statistically significant differences between PD patients and controls. However, patients with met/met genotype performed significantly worse on WAIS-RC similarities, a measure of executive function, compared to individuals with val/val genotype. Subsequent ANCOVA analysis revealed that COMT genotype interacted with sex and daily levodopa equivalent dose (LED) to influence executive function. Further stratified analysis showed that the lower-activity COMT met/met genotype has a detrimental effect on executive function among women. Our results demonstrate that COMT Val158Met polymorphism is probably not associated with increased risk of PD, but has an effect on prefrontal executive function interacting with gender and dopaminergic medication. Copyright © 2016. Published by Elsevier B.V.

  20. 78 FR 20889 - Foreign-Trade Zone (FTZ) 158-Vicksburg/Jackson, Mississippi; Notification of Proposed Production...

    Science.gov (United States)

    2013-04-08

    ... Foreign-Trade Zones Board Foreign-Trade Zone (FTZ) 158--Vicksburg/Jackson, Mississippi; Notification of Proposed Production Activity; Bauhaus USA, Inc.; (Upholstered Furniture); Saltillo, Mississippi The Greater Mississippi Foreign-Trade Zone, Inc., grantee of FTZ 158, submitted a notification of proposed production...

  1. 17 CFR 230.158 - Definitions of certain terms in the last paragraph of section 11(a).

    Science.gov (United States)

    2010-04-01

    ... in the last paragraph of section 11(a). 230.158 Section 230.158 Commodity and Securities Exchanges... Definitions of certain terms in the last paragraph of section 11(a). (a) An “earning statement” made generally available to securityholders of the registrant pursuant to the last paragraph of section 11(a) of the Act...

  2. Synthesis and crystal structure of terbium(III) meta-oxoborate Tb(BO{sub 2}){sub 3} ({identical_to} TbB{sub 3}O{sub 6}); Synthese und Kristallstruktur von Terbium(III)-meta-Oxoborat Tb(BO{sub 2}){sub 3} ({identical_to} TbB{sub 3}O{sub 6})

    Energy Technology Data Exchange (ETDEWEB)

    Nikelski, Tanja; Schleid, Thomas [Institut fuer Anorganische Chemie der Universitaet Stuttgart (Germany)

    2003-06-01

    The terbium meta-oxoborate Tb(BO{sub 2}){sub 3} ({identical_to} TbB{sub 3}O{sub 6}) is obtained as single crystals by the reaction of terbium, Tb{sub 4}O{sub 7} and TbCl{sub 3} with an excess of B{sub 2}O{sub 3} in gastight sealed platinum ampoules at 950 C after three weeks. The compound appears to be air- and water-resistant and crystallizes as long, thin, colourless needles which tend to growth-twinning due to their marked fibrous habit. The crystal structure of Tb(BO{sub 2}){sub 3} (orthorhombic, Pnma; a = 1598.97(9), b = 741.39(4), c = 1229.58(7) pm; Z = 16) contains strongly corrugated oxoborate layers {sub {infinity}}{sup 2}{l_brace}(BO{sub 2}){sup -}{r_brace} built of vertex-linked [BO{sub 4}]{sup 5-} tetrahedra (d(B-O) = 143 - 154 pm, and angsph;(O-B-O) = 102-115 ) which spread out parallel (100). The four crystallographically different Tb{sup 3+} cations all exhibit coordination numbers of eight towards the oxygen atoms (d(Tb-O) = 228-287 pm). The corresponding metal cation polyhedra [TbO{sub 8}]{sup 13+} too convene to layers (composition: {sub {infinity}}{sup 2}{l_brace}(Tb{sub 2}O{sub 11}){sup 16-}{r_brace}) which are likewise oriented parallel to the (100) plane. (Abstract Copyright [2003], Wiley Periodicals, Inc.) [German] Das Terbium-meta-Oxoborat Tb(BO{sub 2}){sub 3} ({identical_to} TbB{sub 3}O{sub 6}) entsteht einkristallin bei der Reaktion von Terbium, Tb{sub 4}O{sub 7} und TbCl{sub 3} mit einem Ueberschuss von B{sub 2}O{sub 3} in gasdicht verschlossenen Platinampullen nach drei Wochen bei 950 C. Die Verbindung ist luft- und wasserstabil und faellt in langen, duennen, farblosen Nadeln an, die aufgrund ihres ausgepraegt faserigen Habitus zur Wachstumsverzwillingung neigen. Die Kristallstruktur von Tb(BO{sub 2}){sub 3} (orthorhombisch, Pnma; a = 1598, 97(9), b = 741, 39(4), c = 1229, 58(7) pm; Z = 16) enthaelt parallel (100) verlaufende, stark gewellte Oxoborat-Schichten {sub {infinity}}{sup 2}{l_brace}(BO{sub 2}){sup -}{r_brace} aus

  3. Precise measurement in elastic electron scattering: HAPPEX and E-158 experiments; Mesures precises de violation de parite en diffusion d'electrons: experiences HAPPEX et E-158

    Energy Technology Data Exchange (ETDEWEB)

    Vacheret, A

    2004-12-01

    Parity Violation asymmetry measurements in elastic electron scattering are in one hand an interesting way of retrieving new informations about the sea quarks of the nucleon and in the other hand a powerful test of the Standard Model electroweak sector at low energy. This thesis describes the HAPPEX experiment at JLab and the E-158 experiment at SLAC (USA) which measure de parity violation asymmetries in elastic scattering of polarized electron on nuclei like Hydrogen or Helium and on atomic electrons. With the measurements on hadronic targets one can extract the strange quarks contribution to the charge and current density of the nucleon. With the electron-electron scattering one can test the standard model at the loop level and far from the Z pole by extracting sin{sup 2} {theta}{sub W}. In this thesis we describe the formalism associated with the electroweak probe. We present in detail the experimental methods used to make such precise measurements of parity violation asymmetry. Then, we describe the experimental set-up of each experiment and in particular the electron detector and the feedback loop on the beam current for the HAPPEX experiment and the analysis of E-158 run III with a dedicated systematic study on the beam sub-pulse fluctuations. We present the preliminary results for each experiment with a comparison with the other existing results and the future experiments. (author)

  4. Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility.

    LENUS (Irish Health Repository)

    McGrath, Emma

    2012-02-01

    PROBLEM: Cycle-dependent fluctuations in natural killer (NK) cell populations in endometrium and circulation may differ, contributing to unexplained infertility. METHOD OF STUDY: NK cell phenotypes were determined by flow cytometry in endometrial biopsies and matched blood samples. RESULTS: While circulating and endometrial T cell populations remained constant throughout the menstrual cycle in fertile and infertile women, circulating NK cells in infertile women increased during the secretory phase. However, increased expression of CD94, CD158b (secretory phase), and CD158a (proliferative phase) by endometrial NK cells from infertile women was observed. These changes were not reflected in the circulation. CONCLUSION: In infertile women, changes in circulating NK cell percentages are found exclusively during the secretory phase and not in endometrium; cycle-related changes in NK receptor expression are observed only in infertile endometrium. While having exciting implications for understanding NK cell function in fertility, our data emphasize the difficulty in attaching diagnostic or prognostic significance to NK cell analyses in individual patients.

  5. 158. Solanaceae

    DEFF Research Database (Denmark)

    Friis, Ib

    2007-01-01

    A taxonomic revision and a floristic account of all species in the plant family Solanaceae (nightshade family) recorded from Ethiopia and Eritrea.......A taxonomic revision and a floristic account of all species in the plant family Solanaceae (nightshade family) recorded from Ethiopia and Eritrea....

  6. P158

    Directory of Open Access Journals (Sweden)

    N. Dementyeva

    2015-11-01

    Work was conducted with the application of the Tomsk regional common use center technical equipment acquired thanks to a grant of the Russian Ministry of the Agreement No. 14.594.21.0001 (RFMEFI59414X0001. This project is supported by “The Tomsk State University Academic D.I. Mendeleev Fund Program” under Grant (No. 18.1.52.2015.

  7. An integrated logic system for time-resolved fluorescent "turn-on" detection of cysteine and histidine base on terbium (III) coordination polymer-copper (II) ensemble.

    Science.gov (United States)

    Xue, Shi-Fan; Lu, Ling-Fei; Wang, Qi-Xian; Zhang, Shengqiang; Zhang, Min; Shi, Guoyue

    2016-09-01

    Cysteine (Cys) and histidine (His) both play indispensable roles in many important biological activities. An enhanced Cys level can result in Alzheimer's and cardiovascular diseases. Likewise, His plays a significant role in the growth and repair of tissues as well as in controlling the transmission of metal elements in biological bases. Therefore, it is meaningful to detect Cys and His simultaneously. In this work, a novel terbium (III) coordination polymer-Cu (II) ensemble (Tb(3+)/GMP-Cu(2+)) was proposed. Guanosine monophosphate (GMP) can self-assemble with Tb(3+) to form a supramolecular Tb(3+) coordination polymer (Tb(3+)/GMP), which can be suited as a time-resolved probe. The fluorescence of Tb(3+)/GMP would be quenched upon the addition of Cu(2+), and then the fluorescence of the as-prepared Tb(3+)/GMP-Cu(2+) ensemble would be restored again in the presence of Cys or His. By incorporating N-Ethylmaleimide and Ni(2+) as masking agents, Tb(3+)/GMP-Cu(2+) was further exploited as an integrated logic system and a specific time-resolved fluorescent "turn-on" assay for simultaneously sensing His and Cys was designed. Meanwhile it can also be used in plasma samples, showing great potential to meet the need of practical application. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Synthesis and photoluminescence properties of cerium-doped terbium-yttrium aluminum garnet phosphor for white light-emitting diodes applications

    Science.gov (United States)

    Wang, Jun; Han, Tao; Lang, Tianchun; Tu, Mingjing; Peng, Lingling

    2015-11-01

    Cerium-doped terbium-yttrium aluminum garnet phosphors were synthesized using the solid-state reaction method. The crystalline phase, morphology, and photoluminescence properties were characterized by x-ray diffraction (XRD), scanning electron microscope (SEM), and fluorescence spectrophotometer, respectively. The XRD results indicate that with an increase of the amount of x (Tb3+), all of the samples have a pure garnet crystal structure without secondary phases. The SEM images reveal that the samples are composed of sphere-like crystallites, which exhibit different degrees of agglomeration. The luminescent properties of Ce ions in )Al5O12∶Ce0.1 have been studied, and it was found that the emission band shifted toward a longer wavelength. The redshift is attributed to the lowering of the 5d energy level centroid of Ce, which can be explained by the nephelauxetic effect and compression effect. These phosphors were coated on blue light-emitting diode (LED) chips to fabricate white light-emitting diodes (WLEDs), and their color-rendering indices, color temperatures, and luminous efficiencies were measured. As a consequence of the addition of Tb, the blue LED pumped )Al5O12∶Ce0.1 phosphors WLEDs showed good optical properties.

  9. Study on the fluorescent enhancement effect in terbium-gadolinium-protein-sodium dodecyl benzene sulfonate system and its application on sensitive detection of protein at nanogram level.

    Science.gov (United States)

    Sun, Changxia; Yang, Jinghe; Wu, Xia; Liu, Shufang; Su, Benyu

    2004-08-01

    The co-luminescence effect in a terbium-gadolinium-protein-sodium dodecyl benzene sulfonate (SDBS) system is reported here. Based on it, the sensitive quantitative analysis of protein at nanogram levels is established. The co-luminescence mechanism is studied using fluorescence, resonance light scattering (RLS), absorption spectroscopy and NMR measurement. It is considered that protein could be unfolded by SDBS, then a efficacious intramolecular fluorescent energy transfer occurs from unfolded protein to rare earth ions through SDBS acting as a "transfer bridge" to enhance the emission fluorescence of Tb3+ in this ternary complex of Tb-SDBS-BSA, where energy transfer from protein to SDBS by aromatic ring stacking is the most important step. Cooperating with the intramolecular energy transfer above is the intermolecular energy transfer between the simultaneous existing complexes of both Tb3+ and Gd3+. The fluorescence quantum yield is increased by an energy-insulating sheath, which is considered to be another reason for the resulting enhancement of the fluorescence. Förster theory is used to calculate the distribution of enhancing factors and has led to a greater understanding of the mechanisms of energy transfer.

  10. [Studies on luminescence properties of seven ternary complexes of terbium with 1,10-phenanthroline and benzoic acid and its derivatives].

    Science.gov (United States)

    Gao, Zhi-hua; Wang, Shu-ping; Liu, Cui-ge; Ma, Rui-xia; Wang, Rui-fen

    2006-04-01

    Seven ternary complexes of Tb(III) were synthesized with benzoic acid (BA), o-, m-, p-methylbenzoic acid (o-MBA, m-MBA, p-MBA), and o-, m-, p-methoxybenzoic acid (o-MOBA, m-MOBA, p-MOBA) as the first ligand, and 1,10-phenanthroline (phen) as the second ligand. The content of C, H and N were measured by using a Flash-EA model 1112 elemental analyzer. Excitation and luminescence spectra of the title solid complexes were recorded by using a Hitachi F-4500 fluorescence spectrophotometer at room temperature. The effects of different varieties and different positions of replacing benzoic acid as the first ligand on fluorescence properties of the ternary complexes of terbium were discussed. The results indicated that the intensity of 5D4-->7F6 (489 nm) and 5D4-->7F5 (545 nm) of substituting benzoic acid complexes was stronger than benzoic acid. Three ternary complexes of Tb(III) with o-, m-, p-methylbenzoic acid showed emission intensity in the consecution: Tb(o-MBA)3 phenMOBA)3phen x H2O>Tb(m-MOBA)3phen x H2O>Tb(p-MOBA)3 phen.

  11. Multifractal moments in heavy ion Pb-Pb collisions at 158 A GeV

    Energy Technology Data Exchange (ETDEWEB)

    Dutt, Sunil [Department of Physics, Govt. College for Women GandhiNagar, Jammu - J& K (India)

    2016-05-06

    In present work, we use the method of scaled factorial moments to search for intermittent behavior in Pb-Pb interactions at 158 A GeV. The analysis is done on photon distributions obtained using preshower photon multiplicity detector. Scaled factorial moments are used to study short range fluctuations in pseudorapidity distributions of photons. Scaled factorial moments are calculated using horizontal corrected and vertical analysis. The results are compared with simulation analysis using VENUS event generator.

  12. Directed Flow in 158 A GeV $^{208}Pb$ + $^{208}Pb$ Collisions

    CERN Document Server

    Aggarwal, M.M.; Ahammed, Z.; Angelis, A.L.S.; Antonenko, V.; Arefev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Baldine, A.; Barabach, L.; Barlag, C.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bock, R.; Bohne, E.M.; Borocz, Z.; Bucher, D.; Buijs, A.; Busching, H.; Carlen, L.; Chalyshev, V.; Chattopadhyay, S.; Cherbatchev, R.; Chujo, T.; Claussen, A.; Das, A.C.; Decowski, M.P.; Dzhordzhadze, V.; Donni, P.; Doubovik, I.; Dutta Majumdar, M.R.; El Chenawi, K.; Eliseev, S.; Enosawa, K.; Foka, P.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Gupta, S.K.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Higuchi, R.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Kampert, K.H.; Karadzhev, K.; Karpio, K.; Kato, S.; Kees, S.; Kim, H.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Krumpel, T.; Kugler, A.; Kulinich, P.; Kurata, M.; Kurita, K.; Kuzmin, N.; Langbein, I.; Lebedev, A.; Lee, Y.Y.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Maximov, A.; Mehdiyev, Rashid R.; Mgebrichvili, G.; Miake, Y.; Mikhalev, D.; Mishra, G.C.; Miyamoto, Y.; Morrison, Douglas R.O.; Mukhopadhyay, D.S.; Myalkovsky, V.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Neumaier, S.; Nianine, A.; Nikitin, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Obenshain, F.E.; Oskarsson, A.; Otterlund, I.; Pachr, M.; Parfenov, A.; Pavliouk, S.; Peitzmann, T.; Petracek, V.; Plasil, F.; Pinanaud, W.; Purschke, M.L.; Raven, B.; Rak, J.; Raniwala, R.; Raniwala, S.; Ramamurthy, V.S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sako, H.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.R.; Shabratova, G.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavin, N.; Soderstrom, K.; Solomey, N.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Stuken, D.; Sumbera, M.; Svensson, T.; Trivedi, M.D.; Tsvetkov, A.; Twenhofel, C.; Tykarski, L.; Urbahn, J.; Van Eijndhoven, N.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.S.; Voros, S.; Wyslouch, B.; Yagi, K.; Yokota, Y.; Young, G.R.

    1998-01-01

    The directed flow of protons and positive pions have been studied in 158 A GeV Pb + Pb collisions. A directed flow analysis of the rapidity dependence of the average transverse momentum projected onto the reaction plane is presented for semi-central collisions with impact parameters of approximately 8 fm, where the flow effect is largest. The magnitude of the directed flow is found to be significantly smaller than observed at AGS energies and than RQMD model predictions.

  13. Search for disoriented chiral condensates in 158.A GeV Pb + Pb collisions

    CERN Document Server

    Nayak, T K; Agnihotri, A; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Baldin, A; Barabash, L; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bock, R; Bohne, E M; Bucher, D; Buijs, A; Buis, E J; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Chenawi, K E; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutta-Majumdar, M R; Eliseev, S; Enosawa, K; Feldmann, H; Foka, P Y; Fokin, S L; Frolov, V; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Kim, H; Kolb, B W; Kosarev, I G; Kucheryaev, I; Kugler, A; Kulinich, P A; Kumar, V; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Mahapatra, D P; Man'ko, V I; Martin, M; Maksimov, A; Mehdiyev, R; Mgebrishvili, G; Miake, Y; Mikhalev, D; Mishra, G C; Miyamoto, Y; Mohanty, B; Morrison, D; Mukhopadhyay, D S; Myalkovskii, V; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nishimura, S; Nomokov, P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Parfenov, A; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Plasil, F; Purschke, M L; Räven, B; Rak, J; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Rubio, J M; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Shabratova, G; Sibiryak, Yu; Siemiarczuk, T; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Twenhöfel, C; Tykarski, L; Urbahn, J; van Eijndhoven, N; Van Heeringen, W H; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Vos, M A; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    2000-01-01

    The authors have studied the production of hadrons and photons in the reaction Pb(Pb, X) at 158 A.GeV. They have applied the discrete wavelet transform to the photon and charged-particle correlations in order to obtain a set of father function coefficients. They try to explain the multiplicity fluctuations by means of localized disoriented chiral condensate domains. (7 refs).

  14. Directed and Elliptic Flow in 158 GeV/Nucleon Pb + Pb Collisions

    CERN Document Server

    Appelshäuser, H; Bailey, S J; Barnby, L S; Bartke, J; Barton, R A; Bialkowska, H; Blyth, C O; Bock, R; Bormann, C; Brady, F P; Brockmann, R; Buncic, N; Buncic, P; Caines, H L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Dunn, J; Eckardt, V; Eckardt, F; Ferguson, M I; Fischer, H G; Flier, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Fuchs, M; Gabler, F; Gál, J; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Günther, J; Harris, J W; Hegyi, S; Henkel, T; Hill, L A; Huang, I; Hümmler, H; Igo, G; Irmscher, D; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Melkumov, G L; Mock, A; Molnár, J; Nelson, J M; Odyniec, Grazyna Janina; Pálla, G; Panagiotou, A D; Petridis, A; Piper, A; Porter, R J; Poskanzer, A M; Poziombka, S; Prindle, D J; Pühlhofer, F; Rauch, W; Reid, J G; Rendfort, R; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rudolph, H; Rybicki, A; Sandoval, A; Sann, H; Semenov, A Yu; Schäfer, E; Scjmischke, D; Schmitz, N; Schönfelder, S; Seyboth, P; Seyerlein, J; Siklér, F; Skrzypczak, E; Squier, G T A; Stock, R; Ströbele, H; Szentpétery, I; Sziklay, J; Toy, M; Trainor, T A; Trentalage, S; Ullrich, T; Vassiliou, M; Veztergombi, G; Voloshin, S; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Wienold, T; Wood, L; Yates, T A; Zimányi, J; Zybert, R

    1998-01-01

    The directed and elliptic flow of protons and charged pions has been observed from the semi-central collisions of a 158 GeV/nucleon Pb beam with a Pb target. The rapidity and transverse momentum dependence of the flow has been measured. The directed flow of the pions is opposite to that of the protons but both exhibit negative flow at low pt. The elliptic flow of both is fairly independent of rapidity but rises with pt.

  15. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome.

    Science.gov (United States)

    Hall, Kathryn T; Lembo, Anthony J; Kirsch, Irving; Ziogas, Dimitrios C; Douaiher, Jeffrey; Jensen, Karin B; Conboy, Lisa A; Kelley, John M; Kokkotou, Efi; Kaptchuk, Ted J

    2012-01-01

    Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such as reward, pain, memory and learning. We hypothesized that the COMT functional val158met polymorphism, was a predictor of placebo effects and tested our hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome (IBS). The three treatment arms from this study were: no-treatment ("waitlist"), placebo treatment alone ("limited") and, placebo treatment "augmented" with a supportive patient-health care provider interaction. The primary outcome measure was change from baseline in IBS-Symptom Severity Scale (IBS-SSS) after three weeks of treatment. In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035). The strongest placebo response occurred in met/met homozygotes treated in the augmented placebo arm. A smaller met/met associated effect was observed with limited placebo treatment and there was no effect in the waitlist control. These data support our hypothesis that the COMT val158met polymorphism is a potential biomarker of placebo response.

  16. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome.

    Directory of Open Access Journals (Sweden)

    Kathryn T Hall

    Full Text Available Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT, an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such as reward, pain, memory and learning. We hypothesized that the COMT functional val158met polymorphism, was a predictor of placebo effects and tested our hypothesis in a subset of 104 patients from a previously reported randomized controlled trial in irritable bowel syndrome (IBS. The three treatment arms from this study were: no-treatment ("waitlist", placebo treatment alone ("limited" and, placebo treatment "augmented" with a supportive patient-health care provider interaction. The primary outcome measure was change from baseline in IBS-Symptom Severity Scale (IBS-SSS after three weeks of treatment. In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035. The strongest placebo response occurred in met/met homozygotes treated in the augmented placebo arm. A smaller met/met associated effect was observed with limited placebo treatment and there was no effect in the waitlist control. These data support our hypothesis that the COMT val158met polymorphism is a potential biomarker of placebo response.

  17. Association between the catechol-o-methyltransferase val158met polymorphism with susceptibility and severity of carpal tunnel syndrome

    Directory of Open Access Journals (Sweden)

    Erkol İnal E

    2015-12-01

    Full Text Available Carpal tunnel syndrome (CTS is the most common entrapment neuropathy of the upper extremity. In this study, we aimed to clarify the relationships between the catechol-O-methyltransferase (COMT gene Val158Met (rs4680 polymorphism and development, functional and clinical status of CTS. Ninety-five women with electro diagnostically confirmed CTS and 95 healthy controls were enrolled in the study. The functional and clinical status of the patients was measured by the Turkish version of the Boston Questionnaire and intensity of pain related to the past 2 weeks was evaluated on a visual analog scale (VAS. The Val158Met polymorphism was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP, method. We divided patients according to the genotypes of the Val158Met polymorphism as Val/Val, Val/Met and Met/Met. There were not any significant differences in terms of Val158Met polymorphisms between patients and healthy controls (p >0.05. We also did not find any relationships between the Val158Met polymorphism and CTS (p >0.05. In conclusion, although we did not find any relationships between CTS and the Val158Met polymorphism, we could not generalize this result to the general population. Future studies are warranted to conclude precise associations.

  18. COMT Val158Met and cognition: main effects and interaction with educational attainment.

    Science.gov (United States)

    Enoch, M-A; Waheed, J F; Harris, C R; Albaugh, B; Goldman, D

    2009-02-01

    Studies in children have shown that the genetic influence on cognition is positively correlated with socioeconomic status. Catechol-O-methyltransferase (COMT) Val158Met, a common, functional polymorphism, has been implicated in executive cognition and working memory. Imaging studies have shown that the variant Met allele is associated with more efficient prefrontal cortical processing and better attention but also emotional vulnerability to stress. We hypothesized that COMT Val158Met genotype would interact with years of education (yrs ed), one indicator of socioeconomic adversity, to predict cognitive task performance. We therefore administered the Wechsler Adult Intelligence Scale-Revised (WAIS-R) to 328 community-derived, genotyped, Plains American Indians (mean yrs ed = 12; range = 5-18). We found significant genotypic effects on WAIS-R measures of long-term memory, working memory and attention. The Met allele was associated with improved performance in the Information and Picture Completion subscales; Met/Met homozygotes performed the best. COMT genotype interacted with yrs ed to influence Information and Block Design scores: Met allele carriers' scores improved markedly with increasing yrs ed, whereas the scores of Val/Val individuals were only marginally influenced by yrs ed. There was a crossover of effects at 11-12 yrs ed: in the less educated group, Met allele carriers actually performed worse than Val/Val individuals perhaps because of emotional vulnerability to educational adversity, but in the better educated group, Met allele carriers excelled. Our study in Plains American Indians has shown that COMT Val158Met influences several aspects of cognition and some of its effects are moderated by educational adversity.

  19. Catechol-O-methyltransferase Gene Polymorphism (Val158Met) and Development of Pre-eclampsia.

    Science.gov (United States)

    Taravati, Ali; Tohidi, Fatemeh; Moniri, Mehrnaz; Kamali, Kasra

    2017-02-01

    Catechol-O-methyltransferase (COMT) is a key enzyme in degradation pathways of estrogens and catecholamines. The present meta-analysis was done to elucidate the association of COMT Val158Met polymorphism with pre-eclampsia among pregnant women. A literature search was conducted in electronic databases including PubMed, Scopus, Elsevier, Springer and Google Scholar to find eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals were calculated under dominant, recessive, co-dominant, and allelic models. This meta-analysis included 6 eligible studies consisting 2596 cases and 4223 controls. The ORs for the COMT G472A polymorphism and pre-eclampsia were indicative of positive association under several genetic models. The results indicated that COMT Val158Met polymorphism was significantly associated with the increased risk of pre-eclampsia in recessive model (AA vs. AG + GG: OR = 1.522 [95% CI: 1.089-2.127]; p = 0.014), co-dominant model (AA vs. GG: OR = 1.605 [95% CI: 1.102-2.336]; p = 0.014), and allelic model (A vs. T: OR = 1.200 [95% CI: 1.021-1.402]; p = 0.021). In summary, COMT Val158Met polymorphism is positively associated with the increased risk of pre-eclampsia among pregnant women, especially the homozygous carriers. It could be of value to investigate its association with pre-eclampsia in combination with additional risk factors. However, very large studies with different ethnic population are required to accurately demonstrate the role of this candidate gene in development of pre-eclampsia. Copyright © 2017 IMSS. Published by Elsevier Inc. All rights reserved.

  20. COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia

    DEFF Research Database (Denmark)

    Haraldsson, H Magnus; Ettinger, Ulrich; Magnusdottir, Brynja B

    2009-01-01

    The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls. Gen....... Genotype was not associated with schizophrenia or SPEM, in either group or the combined sample. SPEM deficits in schizophrenia appear to be determined by genotypes other than rs4680, although the study may have lacked power to detect small effects....

  1. A Preliminary Measurement of the Left-Right Parity-Violating ep Asymmetry at E158

    Energy Technology Data Exchange (ETDEWEB)

    Biesiada, J.

    2005-04-11

    This thesis investigates the parity-violating ep asymmetry based on the Run I data produced in Spring of 2002 by the E158 experiment, located at the Stanford Linear Accelerator Center. The main scientific objective of the experiment is the precision measurement of the weak mixing angle of the Standard Model. The ep asymmetry is an important background in the experiment and theoretically interesting in its own right, providing insights into the structure of the proton. The analysis centers upon identifying systematic error and consistency. The definite measurement of the ep asymmetry will await the final reprocessing of the data set during the Fall of 2002.

  2. Long-range correlations in PbPb collisions at 158 a *GeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, J; Betev, L; Bialkowska, H; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csato, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Farantatos, G; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gal, J; Gazdzicki, M; Georgopoulos, G; Gladysz, E; Grebieszkow, K; Hegyi, S; Hohne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; van Leeuwen, M; Levai, P; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnar, J; Mrowczynski, S; Palla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Puhlhofer, F; Renfordt, R; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Schmitz, N; Seyboth, P; Sikler, F; Sitar, B; Skrzypczak, E; Stefanek, G; Stock, R; Strobele, H; Susa, T; Szentpetery, I; Sziklai, J; Trubnikov, V; Varga, D; Vassiliou, M; Veres, G l; Vesztergombi, G; Vranie, D; Wetzler, A; Wlodarczyk, Z; Yoo, l K; Zaranek, J; Zimanyi, J; Feofilov, G; Kolevatov, R; Kondratiev, V; Naumenko, P; Vechernin, V

    2005-01-01

    We present the 1st results of the event-by-event study of long-range correlations between event mean Pt and charged particle multiplicity using NA49 experimental data in two separated rapidity intervals in 158 A *Ge V Pb Pb collisions at the CERN SPS. Noticeable long range correlations are found. The most striking feature is the negative Prn correlation observed for the central PbPb collisions. Results are compared to the predictions of the HIJING event generator and of the String Fusion Model favoring a string fusion hypothesis.

  3. Freeze-Out Parameters in Central 158 AGeV $^{208}Pb$ + $^{208}Pb$ Collisions

    CERN Document Server

    Aggarwal, M M; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Baldin, A; Barabuch, L; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Böck, R K; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Delagrange, H; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S K; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Frolov, V; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Galow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Kim, H; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Martínez, G; Maksimov, A; Mehdiyev, R; Mgebrishvili, G; Miake, Y; Mikhalev, D; Mir, M F; Mishra, G C; Miyamoto, Y; Morrison, D; Mukhopadhyay, D S; Myalkovskii, V; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Parfenov, A; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Plasil, F; Pinganaud, W; Purschke, M L; Räven, B; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, K; Siemiarczuk, T; Silvermyr, D; Sinha, B A; Slavin, N V; Solderstrom, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Tykarski, L; Urbahn, J; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    1999-01-01

    Neutral pion production in central 158AGeV Pb+Pb collisions has been studied in the WA98 experiment at the CERN SPS. The pi0 transverse mass spectrum has been analyzed in terms of a thermal model with hydrodynamic expansion. The high accuracy and large kinematic coverage of the measurement allow to limit previously noted ambiguities in the extracted freeze-out parameters. The results are shown to be sensitive to the shape of the velocity distribution at freeze-out.

  4. Observation of Direct Photons in Central 158 A GeV $^{208}Pb+^{208}Pb$ Collisions

    CERN Document Server

    Aggarwal, M.M.; Ahammed, Z.; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Barlag, C.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bock, R.; Bohne, E.-M.; Borocz, Z.; Bucher, D.; Buijs, A.; Busching, H.; Carlen, L.; Chalyshev, V.; Chattopadhyay, S.; Cherbatchev, R.; Chujo, T.; Claussen, A.; Das, A.C.; Decowski, M.P.; Delagrange, H.; Djordjadze, V.; Donni, P.; Doubovik, I.; Dutt, S.; Dutta Majumdar, M.R.; El Chenawi, K.; Eliseev, S.; Enosawa, K.; Foka, P.; Fokin, S.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Gupta, S.K.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Higuchi, R.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Kampert, K.-H.; Karadjev, K.; Karpio, K.; Kato, S.; Kees, S.; Klein-Bosing, C.; Knoche, S.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Krumpel, T.; Kugler, A.; Kulinich, P.; Kurata, M.; Kurita, K.; Kuzmin, N.; Langbein, I.; Lebedev, A.; Lee, Y.Y.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Mgebrichvili, G.; Miake, Y.; Mir, Md.F.; Mishra, G.C.; Miyamoto, Y.; Mohanty, B.; Mora, M.-J.; Morrison, D.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Neumaier, S.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Obenshain, F.E.; Oskarsson, A.; Otterlund, I.; Pachr, M.; Pavliouk, S.; Peitzmann, T.; Petracek, V.; Pinganaud, W.; Plasil, F.; Poblotzki, U.v.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Ramamurthy, V.S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sako, H.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.-R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Solomey, N.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Stuken, D.; Sumbera, M.; Svensson, T.; Trivedi, M.D.; Tsvetkov, A.; Tykarski, L.; Urbahn, J.; Pijll, E.C.v.d.; Eijndhoven, N.v.; Nieuwenhuizen, G.J.v.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.; Voros, S.; Wyslouch, B.; Yagi, K.; Yokota, Y.; Young, G.R.

    2000-01-01

    A measurement of direct photon production in 208Pb + 208Pb collisions at 158 A GeV has been carried out in the CERN WA98 experiment. The invariant yield of direct photons in central collisions is extracted as a function of transverse momentum in the interval 0.5 1.5 GeV/c. The results constitute the first observation of direct photons in ultrarelativistic heavy-ion collisions which could be significant for diagnosis of quark gluon plasma formation.

  5. Photon flow in 158 A GeV Pb+Pb collisions

    Energy Technology Data Exchange (ETDEWEB)

    Nikolaev, Sergey; Aggarwal, M.M.; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bucher, D.; Buesching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M.P.; Delagrange, H.; Donni, P.; Dutta Majumdar, M.R.; Dubey, A.K.; El Chenawi, K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Karadjev, K.; Karpio, K.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Loehner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G.C.; Mohanty, B.; Mora, M.-J.; Morrison, D.; Mukhanova, T.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Phatak, S.C.; Pinganaud, W.; Plasil, F.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.-R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soederstroem, K.; Soerensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; Pijll, E.C. van der; Eijndhoven, N. van; Nieuwenhuizen, G.J. van; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.; Voeroes, S.; Wyslouch, B.; Young, G.R

    2003-03-10

    Directed and elliptic flow of {pi}{sup 0} - decay photons in 158 A GeV Pb+Pb collisions has been studied near midrapidity in an analysis of data obtained with the photon spectrometer LEDA of the WA98 experiment at the CERN SPS. Preliminary results on the rapidity and transverse momentum dependence of the flow have been obtained for various centrality classes for p{sub T} > 0.2 GeV/c and 2.3 < y < 2.9. The results are compared with the pion flow.

  6. Photon flow in 158 A GeV Pb+Pb collisions

    CERN Document Server

    Nikolaev, S; Angelis, A L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bucher, D; Büsching, H; Carlén, L; Chattopadhyay, S; Decowski, M P; Delagrange, H; Dönni, P; Dutta-Majumdar, M R; Dubey, A K; El-Chenawi, K F; Enosawa, K; Fokin, S L; Frolov, V; Ganti, M S; Garpman, S; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Karadzhev, K; Karpio, K; Kolb, B W; Kosarev, I G; Kucheryaev, I; Kugler, A; Kulinich, P A; Kurata, M; Lebedev, A; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V; Martin, M; Martínez, G; Maksimov, A; Miake, Y; Mishra, G C; Mohanty, B; Mora, M J; Morrison, D; Mukhanova, T; Mukhopadhyay, D S; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Nyanin, A; Nikitin, V; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Oskarsson, A; Otterlund, I; Peitzmann, Thomas; Peressounko, D Yu; Petracek, V; Phatak, S C; Pinganaud, W; Plasil, F; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A A; Tykarski, L; Van den Pijll, E C; van Eijndhoven, N; Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Young, G R

    2003-01-01

    Directed and elliptic flow of pi /sup 0/ decay photons in 158 A GeV Pb+Pb collisions has been studied near midrapidity in an analysis of data obtained with the photon spectrometer LEDA of the WA98 experiment at the CERN SPS. Preliminary results on the rapidity and transverse momentum dependence of the flow have been obtained for various centrality classes for p/sub T/ > 0.2 GeV/c and 2.3 < y < 2.9. The results are compared with the pion flow. (4 refs).

  7. Elliptic emission of $K^{+}$ and $\\pi^{+}$ in 158A GeV Pb + Pb collisions

    CERN Document Server

    Aggarwal, M M; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Baldin, A; Barabash, L; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Böck, R K; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Delagrange, H; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S K; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Frolov, V; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Martínez, G; Maksimov, A; Mehdiyev, R; Mgebrishvili, G; Miake, Y; Mikhalev, D; Mir, M F; Mishra, G C; Miyamoto, Y; Morrison, D; Mohanty, B; Mukhopadhyay, D S; Myalkovskii, V; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Parfenov, A; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Plasil, F; Pinganaud, W; Purschke, M L; Räven, B; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Tykarski, L; Urbahn, J; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    1999-01-01

    An event-by-event analysis of the azimuthal angular correlation with respect to the reaction plane has been carried out for K/sup +/ and pi /sup +/ emission near mid-rapidity in 158A.GeV Pb+Pb collisions. In semi-central collisions, K/sup +/ mesons are found to be preferentially emitted out of the reaction plane, while pi /sup +/ mesons are emitted in the reaction plane. The results suggest that the kaon emission is influenced by in-medium potential effects in addition to collective flow effects. (25 refs).

  8. Localized Charged-Neutral Fluctuations in 158 A GeV Pb+Pb Collisions

    CERN Document Server

    Aggarwal, M.M.; Ahammed, Z.; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Barlag, C.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bock, R.; Bohne, E.M.; Borocz, Z.; Bucher, D.; Buijs, A.; Busching, H.; Carlen, L.; Chalyshev, V.; Chattopadhyay, S.; Cherbatchev, R.; Chujo, T.; Claussen, A.; Das, A.C.; Decowski, M.P.; Delagrange, H.; Djordjadze, V.; Donni, P.; Doubovik, I.; Dubey, A.K.; Dutt, S.; Dutta Majumdar, M.R.; El Chenawi, K.; Eliseev, S.; Enosawa, K.; Foka, P.; Fokin, S.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Gupta, S.K.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Higuchi, R.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Kampert, K.H.; Karadjev, K.; Karpio, K.; Kato, S.; Kees, S.; Klein-Boesing, Christian; Knoche, S.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Krumpel, T.; Kugler, A.; Kulinich, P.; Kurata, M.; Kurita, K.; Kuzmin, N.; Langbein, I.; Lebedev, A.; Lee, Y.Y.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Mgebrichvili, G.; Miake, Y.; Mir, M.F.; Mishra, G.C.; Miyamoto, Y.; Mohanty, B.; Mora, M.J.; Morrison, Douglas R.O.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Neumaier, S.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Obenshain, F.E.; Oskarsson, A.; Otterlund, I.; Pachr, M.; Pavliouk, S.; Peitzmann, T.; Petracek, V.; Pinganaud, W.; Plasil, F.; von Poblotzki, U.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Ramamurthy, V.S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sako, H.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Solomey, N.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Stuken, D.; Sumbera, M.; Svensson, T.; Trivedi, M.D.; Tsvetkov, A.; Tykarski, L.; Urbahn, J.; van den Pijll, E.C.; van Eijndhoven, N.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.S.; Voros, S.; Wyslouch, B.; Yagi, K.; Yokota, Y.; Young, G.R.

    2001-01-01

    First results on the measurement of localized fluctuations in the multiplicity of charged particles and photons produced in central 158 A GeV Pb+Pb collisions are presented. The charged versus neutral correlations in common phase space regions of varying azimuthal size are analyzed by two different methods. The measured results are compared to those from simulations and to those from different types of mixed events. The comparison indicates the presence of non-statistical fluctuations in both charged particle and photon multiplicities in limited azimuthal regions. However, no correlated charge-neutral fluctuations are observed.

  9. Direct Photon Production in 158 A GeV $^{208}Pb+^{208}Pb$ collisions

    CERN Document Server

    Aggarwal, M M; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bock, R; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Delagrange, H; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S K; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Klein-Bösing, C; Knoche, S; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Martínez, G; Maksimov, A; Mgebrishvili, G; Miake, Y; Mir, M F; Mishra, G C; Miyamoto, Y; Mohanty, B; Morrison, D; Mukhopadhyay, D S; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Pinganaud, W; Plasil, F; Poblotzki, U v; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sood, G; Srensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Tykarski, L; Urbahn, J; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wysouch, B; Yagi, K; Yokota, Y; Young, G R

    2001-01-01

    A measurement of direct photon production in 208Pb + 208Pb collisions at 158 A GeV has been carried out in the CERN WA98 experiment. The invariant yield or upper limit of direct photons as a function of transverse momentum in the interval 0.5 1.5 GeV/c in central collisions. The results are compared to proton-induced results and to theoretical predictions. Implications for the dynamics of high-energy heavy-ion collisions are discussed.

  10. Production of $\\Lambda$ hyperons in inelastic p+p interactions at 158 GeV/$c$

    CERN Document Server

    Aduszkiewicz, A.; Andronov, E.; Antićić, T.; Antoniou, N.; Baatar, B.; Bay, F.; Blondel, A.; Bogomilov, M.; Brandin, A.; Bravar, A.; Brzychczyk, J.; Bunyatov, S.A.; Busygina, O.; Christakoglou, P.; Ćirković, M.; Czopowicz, T.; Damyanova, A.; Davis, N.; Dembinski, H.; Deveaux, M.; Diakonos, F.; Di Luise, S.; Dominik, W.; Dumarchez, J.; Dynowski, K.; Engel, R.; Ereditato, A.; Feofilov, G.A.; Fodor, Z.; Garibov, A.; Gazdzicki, M.; Golubeva, M.; Grebieszkow, K.; Grzeszczuk, A.; Guber, F.; Haesler, A.; Hasegawa, T.; Hervé, A.E.; Hierholzer, M.; Igolkin, S.; Ivashkin, A.; Johnson, S.R.; Kadija, K.; Kapoyannis, A.; Kaptur, E.; Kisiel, J.; Kobayashi, T.; Kolesnikov, V.I.; Kolev, D.; Kondratiev, V.P.; Korzenev, A.; Kowalik, K.; Kowalski, S.; Koziel, M.; Krasnoperov, A.; Kuich, M.; Kurepin, A.; Larsen, D.; László, A.; Lewicki, M.; Lyubushkin, V.V.; Maćkowiak-Pawłowska, M.; Maksiak, B.; Malakhov, A.I.; Manić, D.; Marcinek, A.; Marino, A.D.; Marton, K.; Mathes, H.J.; Matulewicz, T.; Matveev, V.; Melkumov, G.L.; Messerly, B.; Mills, G.B.; Morozov, S.; Mrówczyński, S.; Nagai, Y.; Nakadaira, T.; Naskręt, M.; Nirkko, M.; Nishikawa, K.; Panagiotou, A.D.; Paolone, V.; Pavin, M.; Petukhov, O.; Pistillo, C.; Płaneta, R.; Popov, B.A.; Posiadała, M.; Puławski, S.; Puzović, J.; Rauch, W.; Ravonel, M.; Redij, A.; Renfordt, R.; Richter-Wąs, E.; Robert, A.; Röhrich, D.; Rondio, E.; Roth, M.; Rubbia, A.; Rumberger, B.T.; Rustamov, A.; Rybczynski, M.; Sadovsky, A.; Sakashita, K.; Schmidt, K.; Sekiguchi, T.; Selyuzhenkov, I.; Seryakov, A.; Seyboth, P.; Sgalaberna, D.; Shibata, M.; Słodkowski, M.; Staszel, P.; Stepaniak, J.; Stefanek, G.; Ströbele, H.; Šuša, T.; Szuba, M.; Tada, M.; Taranenko, A.; Tefelski, D.; Tereshchenko, V.; Tsenov, R.; Turko, L.; Ulrich, R.; Unger, M.; Vassiliou, M.; Veberič, D.; Vechernin, V.V.; Vesztergombi, G.; Vinogradov, L.; Wilczek, A.; Włodarczyk, Z.; Wojtaszek-Szwarc, A.; Wyszyński, O.; Zambelli, L.; Zimmerman, E.D.; Zambelli, L.; Zimmermann, E.D.

    2016-01-01

    Inclusive production of $\\Lambda$-hyperons was measured with the large acceptance NA61/SHINE spectrometer at the CERN SPS in inelastic p+p interactions at beam momentum of 158 GeVc. Spectra of transverse momentum and transverse mass as well as distributions of rapidity and x$_{_F}$ are presented. The mean multiplicity was estimated to be $0.120\\,\\pm0.006\\;(stat.)\\,\\pm 0.010\\;(sys.)$. The results are compared with previous measurements and predictions of the EPOS, UrQMD and FRITIOF models.

  11. Two-proton correlations from 158 A GeV Pb + Pb central collisions

    CERN Document Server

    Appelshauser, H.; Bailey, S.J.; Barna, D.; Barnby, L.S.; Bartke, J.; Barton, R.A.; Betev, L.; Bialkowska, H.; Billmeier, A.; Blyth, C.O.; Bock, R.; Boimska, B.; Bormann, C.; Brady, F.P.; Brockmann, R.; Brun, R.; Buncic, P.; Caines, H.L.; Carr, L.D.; Cebra, D.A.; Cooper, G.E.; Cramer, J.G.; Cristinziani, M.; Csato, P.; Dunn, J.; Eckardt, V.; Eckhardt, F.; Ferguson, M.I.; Fischer, H.G.; Flierl, D.; Fodor, Z.; Foka, P.; Freund, P.; Friese, V.; Fuchs, M.; Gabler, F.; Gal, J.; Ganz, R.; Gazdzicki, M.; Geist, Walter M.; Gladysz, E.; Grebieszkow, J.; Gunther, J.; Harris, J.W.; Hegyi, S.; Henkel, T.; Hill, L.A.; Hummler, H.; Igo, G.; Irmscher, D.; Jacobs, P.; Jones, P.G.; Kadija, K.; Kolesnikov, V.I.; Kowalski, M.; Lasiuk, B.; Lednicky, R.; Levai, P.; Malakhov, A.I.; Margetis, S.; Markert, C.; Melkumov, G.L.; Mock, A.; Molnar, J.; Nelson, John M.; Oldenburg, M.; Odyniec, G.; Palla, G.; Panagiotou, A.D.; Petridis, A.; Piper, A.; Porter, R.J.; Poskanzer, Arthur M.; Prindle, D.J.; Puhlhofer, F.; Susa, T.; Reid, J.G.; Renfordt, R.; Retyk, W.; Ritter, H.G.; Rohrich, D.; Roland, C.; Roland, G.; Rudolph, H.; Rybicki, A.; Sammer, T.; Sandoval, A.; Sann, H.; Semenov, A.Yu.; Schafer, E.; Schmischke, D.; Schmitz, N.; Schonfelder, S.; Seyboth, P.; Sikler, F.; Skrzypczak, E.; Snellings, R.; Squier, G.T.A.; Stock, R.; Strobele, H.; Struck, Chr.; Szentpetery, I.; Sziklai, J.; Toy, M.; Trainor, T.A.; Trentalange, S.; Ullrich, T.; Vassiliou, M.; Veres, G.; Vesztergombi, G.; Voloshin, S.; Vranic, D.; Wang, F.; Weerasundara, D.D.; Wenig, S.; Whitten, C.; Wood, L.; Xu, N.; Yates, T.A.; Zimanyi, J.; Zhu, X.Z.; Zybert, R.

    1999-01-01

    The two-proton correlation function at midrapidity from Pb+Pb central collisions at 158 AGeV has been measured by the NA49 experiment. The results are compared to model predictions from static thermal Gaussian proton source distributions and transport models RQMD and VENUS. An effective proton source size is determined by minimizing CHI-square/ndf between the correlation functions of the data and those calculated for the Gaussian sources, yielding 3.85 +- 0.15 (stat.) +- 0.15 (syst.) fm. The RQMD model overpredicts the effective source size, while the VENUS model underpredicts the effective source size.

  12. High-spin excitations in {sup 158,159,160}Hf from recoil-decay tagging

    Energy Technology Data Exchange (ETDEWEB)

    Ding, K. Y. [Department of Physics and Astronomy, Rutgers University, New Brunswick, New Jersey 08903 (United States); Cizewski, J. A. [Department of Physics and Astronomy, Rutgers University, New Brunswick, New Jersey 08903 (United States); Seweryniak, D. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Amro, H. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Carpenter, M. P. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Davids, C. N. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Fotiades, N. [Department of Physics and Astronomy, Rutgers University, New Brunswick, New Jersey 08903 (United States); Janssens, R. V. F. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Lauritsen, T. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Lister, C. J. [Argonne National Laboratory, Argonne, Illinois 60439 (United States)] (and others)

    2000-09-01

    The 270-MeV {sup 58}Ni+{sup A}Pd reaction was used for the first recoil-decay tagging measurement with Gammasphere coupled to the Fragment Mass Analyzer at Argonne National Laboratory. Level structures of {sup 158}Hf and {sup 159}Hf are identified for the first time, and that of {sup 160}Hf is extended. The systematical behavior of the energy levels in neighboring isotones and isotopes, as well as the aligned angular momenta as a function of rotational frequency, are examined. (c) 2000 The American Physical Society.

  13. Multifragmentation of the Pb projectile at 158 GeV/nucleon in Pb-Pb interactions

    Energy Technology Data Exchange (ETDEWEB)

    Holynski, R.; Dabrowska, A.; Olszewski, A.; Szarska, M.; Trzupek, A.; Wilczynska, B.; Wilczynski, H.; Wolter, W.; Wosiek, B.; Wozniak, K. [Institute of Nuclear Physics, Cracow (Poland); Cherry, M.L.; Deines-Jones, P.; Nilsen, B.S.; Waddington, C.J.; Wefel, J.P.

    1999-06-01

    We have investigated the process of fragmentation of the Pb nucleus at 158 GeV/nucleon in Pb-Pb interactions recorded in the lead-emulsion chambers of the EMU13 CERN experiment. The number of Pb-Pb interactions found was larger than expected from the nuclear charge changing cross section, which indicates an important role of electromagnetic dissociation processes in Pb-Pb interactions at this energy. Different modes of the Pb projectile break-up, including the multifragmentation process, are discussed. The rates and properties of fragmentation processes such as fission, multifragmentation and disintegration into singly charged fragments are presented. (orig.) 7 refs.

  14. Transverse Momentum Fluctuations in Nuclear Collisions at 158 AGeV

    CERN Document Server

    Anticic, T.; Barna, D.; Bartke, J.; Behler, M.; Betev, L.; Bialkowska, H.; Billmeier, A.; Blume, C.; Boimska, B.; Botje, M.; Bracinik, J.; Bramm, R.; Brun, R.; Buncic, P.; Cerny, V.; Christakoglou, P.; Chvala, O.; Cramer, J.G.; Csato, P.; Darmenov, N.; Dimitrov, A.; Dinkelaker, P.; Eckardt, V.; Filip, P.; Flierl, D.; Fodor, Z.; Foka, P.; Freund, P.; Friese, V.; Gal, J.; Gazdzicki, M.; Georgopoulos, G.; Gladysz, E.; Hegyi, S.; Hohne, C.; Kadija, K.; Karev, A.; Kolesnikov, V.I.; Kollegger, T.; Korus, R.; Kowalski, M.; Kraus, I.; Kreps, M.; van Leeuwen, M.; Levai, P.; Litov, L.; Makariev, M.; Malakhov, A.I.; Markert, C.; Mateev, M.; Mayes, B.W.; Melkumov, G.L.; Meurer, C.; Mischke, A.; Mitrovski, M.; Molnar, J.; Mrowczynski, S.; Palla, G.; Panagiotou, A.D.; Panayotov, D.; Perl, K.; Petridis, A.; Pikna, M.; Pinsky, Lawrence S.; Puhlhofer, F.; Reid, J.G.; Renfordt, R.; Retyk, W.; Roland, C.; Roland, G.; Rybczynski, M.; Rybicki, A.; Sandoval, A.; Sann, H.; Schmitz, N.; Seyboth, P.; Sikler, F.; Sitar, B.; Skrzypczak, E.; Stefanek, G.; Stock, R.; Strobele, H.; Susa, T.; Szentpetery, I.; Sziklai, J.; Trainor, T.A.; Varga, D.; Vassiliou, M.; Veres, G.I.; Vesztergombi, G.; Vranic, D.; Wetzler, A.; Wlodarczyk, Z.; Yoo, I.K.; Zaranek, J.; Zimanyi, J.

    2004-01-01

    Results are presented on event-by-event fluctuations in transverse momentum of charged particles, produced at forward rapidities in p+p, C+C, Si+Si and Pb+Pb collisions at 158 AGeV. Three different characteristics are discussed: the average transverse momentum of the event, the Phi_pT fluctuation measure and two-particle transverse momentum correlations. In the kinematic region explored, the dynamical fluctuations are found to be small. However, a significant system size dependence of Phi_pT is observed, with the largest value measured in peripheral Pb+Pb interactions. The data are compared with predictions of several models.

  15. Self-diffusion coefficients of the trivalent f-element ion series in dilute and moderately dilute aqueous solutions: A comparative study between europium, gadolinium, terbium and berkelium

    Science.gov (United States)

    Rafik, Besbes; Noureddine, Ouerfelli; Abderabbou, Abdelmanef; Habib, Latrous

    2010-03-01

    We have continued the studies on the trivalent ions of the 4f and 5f elements. In this paper, we compare the transport properties (self-diffusion coefficient) of the trivalent aquo ions over two ranges of concentrations (0 — 2×10-3M) and (2×10-3 — 1.5M). Self-diffusion coefficients, D, of the trivalent f-element aquo ion series have been determined in aqueous background electrolytes of Gd(NO3)3 and Nd(ClO4)3, at pH=2.5 (HNO3, HClO4) and at 25°C using the open-end capillary method (O.E.C.M.). This method measures the transportation time of ions across a fixed distance. In this paper, we complete a measurement of self-diffusion coefficient for terbium. We optimized the pH to avoid hydrolysis, ion-pairing and complexation of the trivalent 4f and 5f ions. The variation of D versus √C is not linear for dilute solutions (0 — 2×10-3M) and quasi-linear in moderate concentrations (C<=1.5 M). Similar behavior was observed for Tb, as compared with those for Bk, Eu and Gd. We complete the comparison variation of D/D° versus √C for all studied 4f and 5f elements from concentration 0 to 1.5M and we obtained the same variation with √C for all studied elements. All 4f and 5f elements studied follow the Nernst-Hartley expression.

  16. Terbium-based time-gated Förster resonance energy transfer imaging for evaluating protein-protein interactions on cell membranes.

    Science.gov (United States)

    Lindén, Stina; Singh, Manish Kumar; Wegner, K David; Regairaz, Marie; Dautry, François; Treussart, François; Hildebrandt, Niko

    2015-03-21

    Fluorescence imaging of cells and subcellular compartments is an essential tool to investigate biological processes and to evaluate the development and progression of diseases. In particular, protein-protein interactions can be monitored by Förster resonance energy transfer (FRET) between two proximal fluorophores that are attached to specific recognition biomolecules such as antibodies. We investigated the membrane expression of E- and N-cadherins in three different cell lines used as model systems to study epithelial to mesenchymal transition (EMT) and a possible detection of circulating tumour cells (CTCs). EMT is a key process in cancer metastasis, during which epithelial markers (such as E-cadherin) are down-regulated in the primary tumour whereas mesenchymal markers (such as N-cadherin) are up-regulated, leading to enhanced cell motility, intravasation, and appearance of CTCs. Various FRET donor-acceptor pairs and protein recognition strategies were utilized, in which Lumi4-Tb terbium complexes (Tb) and different organic dyes were conjugated to several distinct E- and N-cadherin-specific antibodies. Pulsed excitation of Tb at low repetition rates (100 Hz) and time-gated (TG) imaging of both the Tb-donor and the dye-acceptor photoluminescence (PL) allowed efficient detection of the EMT markers as well as FRET in the case of sufficient donor-acceptor proximity. Efficient FRET was observed only between two E-cadherin-specific antibodies and further experiments indicated that these antibodies recognized the same E-cadherin molecule, suggesting a limited accessibility of cadherins when they are clustered at adherens junctions. The investigated Tb-to-dye FRET systems provided reduced photobleaching compared to the AlexaFluor 488-568 donor-acceptor pair. Our results demonstrate the applicability and advantages of Tb-based TG FRET for efficient and stable imaging of antibody-antibody interactions on different cell lines. They also reveal the limitations of

  17. A broad G protein-coupled receptor internalization assay that combines SNAP-tag labeling, diffusion-enhanced resonance energy transfer, and a highly emissive terbium cryptate acceptor

    Directory of Open Access Journals (Sweden)

    Angélique eLEVOYE

    2015-11-01

    Full Text Available Although G protein-coupled receptor (GPCR internalization has long been considered a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Internalization thus contributes to the diversity of GPCR-dependent signaling, and its dynamics and quantification in living cells has generated considerable interest. We developed a robust and sensitive assay to follow and quantify ligand-induced and constitutive GPCR internalization but also receptor recycling in living cells. This assay is based on diffusion-enhanced resonance energy transfer (DERET between cell surface GPCRs labeled with a luminescent terbium cryptate donor and a fluorescein acceptor present in the culture medium. GPCR internalization results in a quantifiable reduction of energy transfer. This method yields a high signal-to-noise ratio due to time-resolved measurements. For various GPCRs belonging to different classes, we demonstrated that constitutive and ligand-induced internalization could be monitored as a function of time and ligand concentration, thus allowing accurate quantitative determination of kinetics of receptor internalization but also half-maximal effective or inhibitory concentrations of compounds. In addition to its selectivity and sensitivity, we provided evidence that DERET-based internalization assay is particularly suitable for characterizing biased ligands. Furthermore, the determination of a Z’-factor value of 0.45 indicates the quality and suitability of DERET-based internalization assay for high-throughput screening (HTS of compounds that may modulate GPCRs internalization.

  18. Crystal structure of an eight-coordinate terbium(III ion chelated by N,N′-bis(2-hydroxybenzyl-N,N′-bis(pyridin-2-ylmethylethylenediamine (bbpen2− and nitrate

    Directory of Open Access Journals (Sweden)

    Thaiane Gregório

    2015-01-01

    Full Text Available The reaction of terbium(III nitrate pentahydrate in acetonitrile with N,N′-bis(2-hydroxybenzyl-N,N′-bis(pyridin-2-ylmethylethylenediamine (H2bbpen, previously deprotonated with triethylamine, produced the mononuclear compound [N,N′-bis(2-oxidobenzyl-κO-N,N′-bis(pyridin-2-ylmethyl-κNethylenediamine-κ2N,N′](nitrato-κ2O,O′terbium(III, [Tb(C28H28N4O2(NO3]. The molecule lies on a twofold rotation axis and the TbIII ion is eight-coordinate with a slightly distorted dodecahedral coordination geometry. In the symmetry-unique part of the molecule, the pyridine and benzene rings are both essentially planar and form a dihedral angle of 61.42 (7°. In the molecular structure, the N4O4 coordination environment is defined by the hexadentate bbpen ligand and the bidentate nitrate anion. In the crystal, a weak C—H...O hydrogen bond links molecules into a two-dimensional network parallel to (001.

  19. The COMT Val158Met polymorphism modulates working memory performance under acute stress.

    Science.gov (United States)

    Buckert, Magdalena; Kudielka, Brigitte M; Reuter, Martin; Fiebach, Christian J

    2012-11-01

    One of the most widely studied genetic polymorphisms regarding cognitive and emotional phenotypes is the COMT Val158Met polymorphism that influences dopamine availability in the prefrontal cortex (PFC). The PFC is the key brain structure for higher cognitive functions such as working memory, as well as an important regulatory site and target of the psychoendocrine stress response. Dopamine is thought to influence PFC functions in an inverted u-shaped manner. Thus, a stress-related increase in prefrontal dopamine is hypothesized to exert differential effects on working memory performance depending on the genetically determined baseline dopamine level in the PFC. Thirty-three healthy young subjects homozygous for the COMT Val158Met polymorphism were selected from a larger pre-genotyped sample. They performed an n-back working memory task after exposure to a laboratory psychosocial stress induction paradigm (The Trier Social Stress Test for Groups; TSST-G). Under stress, working memory performance of Met homozygotes was significantly worse than working memory performance of Val homozygotes. Importantly, this genotype effect was restricted to the medium difficulty level of the n-back task. Our results demonstrate that working memory performance under stress is influenced by genetic variation in prefrontal dopamine levels. More generally, our results point to the importance of considering the complex interaction of genes, environment, and task variables. Copyright © 2012 Elsevier Ltd. All rights reserved.

  20. COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers

    Science.gov (United States)

    Herman, Aryeh I.; Jatlow, Peter I.; Gelernter, Joel; Listman, Jennifer B.; Sofuoglu, Mehmet

    2013-01-01

    The COMT Val158Met polymorphism may be a risk factor for nicotine addiction. This study examined the influence of the COMT Val158Met polymorphism on subjective, physiological, and cognitive effects of intravenous (IV) nicotine use in African American (AAs) (n=56) and European American (EAs) (n=68) smokers. Overnight abstinent smokers received saline followed by 0.5 and 1.0 mg/70 kg doses of nicotine, administered 30 minutes apart. Smokers with Val/Val genotype, compared to Met carriers, had greater negative subjective effects from IV nicotine and had more severe withdrawal severity following overnight abstinence from smoking. Women with Val/Val genotype reported greater difficulty concentrating and irritability than men with Val/Val or Met carrier genotypes. The Val/Val genotype was associated with better performance on the math task and in AA smokers it was associated with greater systolic blood pressure. These results support the rationale of pharmacologically inhibiting COMT to aid with smoking cessation among Val/Val genotype smokers. PMID:23459442

  1. Pulse Pressure magnifies the effect of COMTVal158Met on 15 Year Episodic Memory Trajectories

    Directory of Open Access Journals (Sweden)

    Ninni ePersson

    2016-03-01

    Full Text Available We investigated whether a physiological marker of cardiovascular health, pulse pres­sure (PP, and age magnified the effect of the functional COMT Val158Met (rs4680 pol­ymor­phism on 15-year cognitive trajectories (episodic memory [EM], visuospatial ability, and se­man­tic memory using data from 1585 non-demented adults from the Betula study. A mul­tiple-group growth model was specified to gauge individual differences in change. The allelic variants showed negligible differences across the cognitive markers in average trends. The older portion of the sample selectively age-magnified the effects of Val158Met on EM changes, resulting in greater decline in Val compared to homozygote Met carriers. This effect was attenuated by sta­tistical control for PP. Further, PP mod­erated the effects of COMT on 15-year EM trajectories, resulting in greater decline in Val carriers, even after accounting for the confounding effects of sex, education, cardiovascular diseases (dia­betes, stroke, and hypertension, and chronological age, controlled for practice gains. The effect was still present after excluding individuals with a history of cardiovascular diseases. The effects of cognitive change were not moderated by any other covariates. This report underscores the importance of addressing synergistic effects in nor­mal cognitive aging, as the addition thereof may even place healthy individuals at greater risk for memory decline.

  2. COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination

    Directory of Open Access Journals (Sweden)

    Rosa Elise C

    2010-09-01

    Full Text Available Abstract Background Dopamine in prefrontal cortex (PFC modulates core cognitive processes, notably working memory and executive control. Dopamine regulating genes and polymorphisms affecting PFC - including Catechol-O-Methyltransferase (COMT Val158Met - are crucial to understanding the molecular genetics of cognitive function and dysfunction. A mechanistic account of the COMT Val158Met effect associates the Met allele with increased tonic dopamine transmission underlying maintenance of relevant information, and the Val allele with increased phasic dopamine transmission underlying the flexibility of updating new information. Thus, consistent with some earlier work, we predicted that Val carriers would display poorer performance when the maintenance component was taxed, while Met carriers would be less efficient when rapid updating was required. Methods Using a Stroop task that manipulated level of required cognitive stability and flexibility, we examined reaction time performance of patients with schizophrenia (n = 67 and healthy controls (n = 186 genotyped for the Val/Met variation. Results In both groups we found a Met advantage for tasks requiring cognitive stability, but no COMT effect when a moderate level of cognitive flexibility was required, or when a conflict cost measure was calculated. Conclusions Our results do not support a simple stability/flexibility model of dopamine COMT Val/Met effects and suggest a somewhat different conceptualization and experimental operationalization of these cognitive components.

  3. Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.

    Science.gov (United States)

    Corradini, Elena; Rozier, Molly; Meynard, Delphine; Odhiambo, Adam; Lin, Herbert Y; Feng, Qi; Migas, Mary C; Britton, Robert S; Babitt, Jodie L; Fleming, Robert E

    2011-11-01

    HFE and transferrin receptor 2 (TFR2) are each necessary for the normal relationship between body iron status and liver hepcidin expression. In murine Hfe and Tfr2 knockout models of hereditary hemochromatosis (HH), signal transduction to hepcidin via the bone morphogenetic protein 6 (Bmp6)/Smad1,5,8 pathway is attenuated. We examined the effect of dietary iron on regulation of hepcidin expression via the Bmp6/Smad1,5,8 pathway using mice with targeted disruption of Tfr2, Hfe, or both genes. Hepatic iron concentrations and messenger RNA expression of Bmp6 and hepcidin were compared with wild-type mice in each of the HH models on standard or iron-loading diets. Liver phospho-Smad (P-Smad)1,5,8 and Id1 messenger RNA levels were measured as markers of Bmp/Smad signaling. Whereas Bmp6 expression was increased, liver hepcidin and Id1 expression were decreased in each of the HH models compared with wild-type mice. Each of the HH models also showed attenuated P-Smad1,5,8 levels relative to liver iron status. Mice with combined Hfe/Tfr2 disruption were most affected. Dietary iron loading increased hepcidin and Id1 expression in each of the HH models. Compared with wild-type mice, HH mice demonstrated attenuated (Hfe knockout) or no increases in P-Smad1,5,8 levels in response to dietary iron loading. These observations show that Tfr2 and Hfe are each required for normal signaling of iron status to hepcidin via the Bmp6/Smad1,5,8 pathway. Mice with combined loss of Hfe and Tfr2 up-regulate hepcidin in response to dietary iron loading without increases in liver Bmp6 messenger RNA or steady-state P-Smad1,5,8 levels. Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.

  4. The Roles of COMT val158met Status and Aviation Expertise in Flight Simulator Performance and Cognitive Ability

    Science.gov (United States)

    Taylor, J. L.; Noda, A.; Adamson, M.; Murphy, G. M.; Zeitzer, J. M.; Yesavage, J. A.

    2011-01-01

    The polymorphic variation in the val158met position of the catechol-O-methyltransferase (COMT) gene is associated with differences in executive performance, processing speed, and attention. The purpose of this study is: (1) replicate previous COMT val158met findings on cognitive performance; (2) determine whether COMT val158met effects extend to a real-world task, aircraft navigation performance in a flight simulator; and (3) determine if aviation expertise moderates any effect of COMT val158met status on flight simulator performance. One hundred seventy two pilots aged 41–69 years, who varied in level of aviation training and experience, completed flight simulator, cognitive, and genetic assessments. Results indicate that although no COMT effect was found for an overall measure of flight performance, a positive effect of the met allele was detected for two aspects of cognitive ability: executive functioning and working memory performance. Pilots with the met/met genotype benefited more from increased levels of expertise than other participants on a traffic avoidance measure, which is a component of flight simulator performance. These preliminary results indicate that COMT val158met polymorphic variation can affect a real-world task. PMID:21193954

  5. Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in children with chronic tension-type headache.

    Science.gov (United States)

    Fernández-de-las-Peñas, César; Ambite-Quesada, Silvia; Rivas-Martínez, Inés; Ortega-Santiago, Ricardo; de-la-Llave-Rincón, Ana Isabel; Fernández-Mayoralas, Daniel M; Pareja, Juan A

    2011-10-01

    Our aim was to investigate the relationship between Val158Met polymorphisms, headache, and pressure hypersensitivity in children with chronic tension-type headache (CTTH). A case-control study with blinded assessor was conducted. Seventy children with CTTH associated with pericranial tenderness and 70 healthy children participated. After amplifying Val158Met polymorphism by polymerase chain reactions, we assessed genotype frequencies and allele distributions. We classified children according to their Val158Met polymorphism: Val/Val, Val/Met, Met/Met. Pressure pain thresholds (PPT) were bilaterally assessed over the temporalis, upper trapezius, second metacarpal, and tibialis anterior muscles. The distribution of Val158Met genotypes was not significantly different (p = 0.335), between children with CTTH and healthy children, and between boys and girls (p = 0.872). Children with CTTH with the Met/Met genotype showed a longer headache history compared with those with Met/Val (p = 0.001) or Val/Val (p = 0.002) genotype. Children with CTTH with Met/Met genotype showed lower PPT over upper trapezius and temporalis muscles than children with CTTH with Met/Val or Val/Val genotype (p < 0.01). The Val158Met catechol-O-methyltransferase (COMT) polymorphism does not appear to be involved in predisposition to suffer from CTTH in children; nevertheless, this genetic factor may be involved in the phenotypic expression, as pressure hypersensitivity was greater in those CTTH children with the Met/Met genotype.

  6. Association between the Catechol O-Methyltransferase (COMT) Val158met Polymorphism and Different Dimensions of Impulsivity

    Science.gov (United States)

    Malloy-Diniz, Leandro Fernandes; Lage, Guilherme Menezes; Campos, Simone Becho; de Paula, Jonas Jardim; de Souza Costa, Danielle; Romano-Silva, Marco Aurélio; de Miranda, Débora Marques; Correa, Humberto

    2013-01-01

    Background Impulsivity is a multidimensional construct which has been associated with dopaminergic neurotransmission. Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met). The present study aimed to investigate the association between val158met COMT polymorphism and impulsive behavior measured by two neuropsychological tests. Methodology/Principal Findings We administered two neuropsychological tests, a Continuous Performance Task and the Iowa Gambling Task were applied to 195 healthy participants to characterize their levels of motor, attentional and non-planning impulsivity. Then, subjects were grouped by genotype, and their scores on impulsivity measures were compared. There were no significant differences between group scores on attentional and motor impulsivity. Those participants who were homozygous for the met allele performed worse in the Iowa Gambling Task than val/val and val/met subjects. Conclusions/Significance Our results suggest that met allele of val158met COMT polymorphism is associated with poor performance in decision-making/cognitive impulsivity task. The results reinforce the hypothesis that val and met alleles of the val158met polymorphism show functional dissociation and are related to different prefrontal processes. PMID:24039968

  7. Association between the Catechol O-methyltransferase (COMT Val158met polymorphism and different dimensions of impulsivity.

    Directory of Open Access Journals (Sweden)

    Leandro Fernandes Malloy-Diniz

    Full Text Available BACKGROUND: Impulsivity is a multidimensional construct which has been associated with dopaminergic neurotransmission. Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val with methionine (met in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met. The present study aimed to investigate the association between val158met COMT polymorphism and impulsive behavior measured by two neuropsychological tests. METHODOLOGY/PRINCIPAL FINDINGS: We administered two neuropsychological tests, a Continuous Performance Task and the Iowa Gambling Task were applied to 195 healthy participants to characterize their levels of motor, attentional and non-planning impulsivity. Then, subjects were grouped by genotype, and their scores on impulsivity measures were compared. There were no significant differences between group scores on attentional and motor impulsivity. Those participants who were homozygous for the met allele performed worse in the Iowa Gambling Task than val/val and val/met subjects. CONCLUSIONS/SIGNIFICANCE: Our results suggest that met allele of val158met COMT polymorphism is associated with poor performance in decision-making/cognitive impulsivity task. The results reinforce the hypothesis that val and met alleles of the val158met polymorphism show functional dissociation and are related to different prefrontal processes.

  8. Val158Met COMT polymorphism and risk of aggression in alcohol dependence.

    Science.gov (United States)

    Soyka, Michael; Zill, Peter; Koller, Gabi; Samochowiec, Agnieszka; Grzywacz, Anna; Preuss, Ulrich W

    2015-01-01

    Aggression, violence and antisocial behavior are common in alcoholism, but their biological basis is poorly understood. Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. We tested this hypothesis in a sample of treatment-seeking alcohol-dependent in-patients (293 German patients and 499 controls, and additional 190 Polish patients as replication sample). As expected, patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism and more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. COMT genotype was not associated with a history of violent or non-violent crime. More studies are needed on the neurobiological basis of aggression and violence in alcoholism. © 2013 Society for the Study of Addiction.

  9. J/$\\psi$ production in proton-nucleus collisions at 158 and 400 GeV

    CERN Document Server

    Arnaldi, R; Castor, J.; Chaurand, B.; Chen, W.; Cicalo, C.; Colla, A.; Cortese, P.; Damjanovic, S.; David, A.; de Falco, A.; Devaux, A.; En'yo, H.; Fargeix, J.; Ferretti, A.; Floris, M.; Foerster, A.; Force, P.; Guettet, N.; Guichard, A.; Gulkanian, H.; Heuser, J.M.; Keil, M.; Li, Z.; Lourenco, C.; Lozano, J.; Manso, F.; Martins, P.; Masoni, A.; Neves, A.; Ohnishi, H.; Oppedisano, C.; Parracho, P.; Pillot, P.; Poghosyan, T.; Puddu, G.; Radermacher, E.; Ramalhete, P.; Rosinsky, P.; Scomparin, E.; Seixas, J.; Serci, S.; Shahoyan, R.; Sonderegger, P.; Specht, H.J.; Uras, A.; Usai, G.; Veenhof, R.; Woehri, H.K.; Banicz, K; Castor, J; Chaurand, B; Chen, W; Cical, C; Colla, A; Cortese, P; Damjanovic, S; David, A; de Falco, A; Devaux, A; Ducroux, L; En'yo, H; Fargeix, J; Ferretti, A; Floris, M; Frster, A; Force, P; Guettet, N; Guichard, A; Gulkanian, H; Heuser, J M; Keil, M; Li, Z; Lourenco, C; Lozano, J; Manso, F; Martins, P; Masoni, A; Neves, A; Ohnishi, H; Oppedisano, C; Parracho, P; Pillot, P; Poghosyan, T; Puddu, G; Radermacher, E; Ramalhete, P; Rosinsky, P; Seixas, J; Serci, S; Shahoyan, R; Sonderegger, P; Specht, H J; Tieulent, R; Uras, A; Usai, G; Veenhof, R; Woehri, H K

    2012-01-05

    The NA60 experiment has studied J/psi production in p-A collisions at 158 and 400 GeV, at the CERN SPS. Nuclear effects on the J/psi yield have been estimated from the A-dependence of the production cross section ratios sigma_{J/psi}^{A}/sigma_{J/psi}^{Be} (A=Al, Cu, In, W, Pb, U). We observe a significant nuclear suppression of the J/psi yield per N-N collision, with a larger effect at lower incident energy, and we compare this result with previous observations by fixed-target experiments. By studying, at the two energies, the dependence of nuclear effects on x_2, the fraction of nucleon momentum carried by the interacting parton from the target nucleus, we conclude that a combination of nuclear shadowing and break-up by target nucleons cannot be the only source of nuclear suppression of the J/psi.

  10. Search for Disoriented Chiral Condensates in 158 AGeV Pb+Pb Collisions

    CERN Document Server

    Aggarwal, M.M.; Ahammed, Z.; Angelis, A.L.S.; Antonenko, V.; Arefev, V.; Astakhov, V.; Avdeichikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Baldine, A.; Barabach, L.; Barlag, C.; Bathe, S.; Batyunya, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bock, R.; Bohne, E.M.; Bucher, D.; Buijs, A.; Buis, E.J.; Busching, H.; Carlen, L.; Chalyshev, V.; Chattopadhyay, S.; Cherbachev, R.; Chujo, T.; Claussen, A.; Das, A.C.; Decowski, M.P.; Dzhordzhadze, V.; Donni, P.; Dubovik, I.; Dutta Majumdar, M.R.; El Chenawi, K.; Eliseev, S.; Enosawa, K.; Foka, P.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Gupta, S.K.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Higuchi, R.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Kampert, K.H.; Karadzhev, K.; Karpio, K.; Kato, S.; Kees, S.; Kim, H.; Kolb, B.W.; Kosarev, I.; Kucheryaev, I.; Kugler, A.; Kulinich, P.; Kumar, V.; Kurata, M.; Kurita, K.; Kuzmin, N.; Langbein, I.; Lebedev, A.; Lee, Y.Y.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Maximov, A.; Mehdiyev, Rashid R.; Mgebrishvili, G.; Miake, Y.; Mikhalev, D.; Mishra, G.C.; Miyamoto, Y.; Morrison, Douglas R.O.; Mukhopadhyay, D.S.; Myalkovsky, V.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Neumaier, S.; Nianine, A.; Nikitin, V.; Nikolaev, S.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Obenshain, F.E.; Oskarsson, A.; Otterlund, I.; Pachr, M.; Parfenov, A.; Pavliouk, S.; Peitzmann, T.; Petracek, V.; Plasil, F.; Purschke, M.L.; Raven, B.; Rak, J.; Raniwala, S.; Ramamurthy, V.S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sako, H.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.R.; Shabratova, G.; Sibaryak, I.; Siemiarczuk, T.; Sinha, B.C.; Slavin, N.; Soderstrom, K.; Solomey, N.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Stuken, D.; Sumbera, M.; Svensson, T.; Trivedi, M.D.; Tsvetkov, A.; Twenhofel, C.; Tykarski, L.; Urbahn, J.; van Eijndhoven, N.; van Heeringen, W.H.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.S.; Voros, S.; Vos, M.A.; Wyslouch, B.; Yagi, K.; Yokota, Y.; Young, G.R.

    1998-01-01

    The restoration of chiral symmetry and its subsequent breaking through a phase transition has been predicted to create regions of Disoriented Chiral Condensates (DCC). This phenomenon has been predicted to cause anomalous fluctuations in the relative production of charged and neutral pions in high-energy hadronic and nuclear collisions. The WA98 experiment has been used to measure charged and photon multiplicities in the central region of 158 AGeV Pb+Pb collisions at the CERN SPS. In a sample of 212646 events, no clear DCC signal can be distinguished. Using a simple DCC model, we have set a 90% C.L. upper limit on the maximum DCC production allowed by the data.

  11. Low mass dimuon production in indium-indium collisions at 158 A GeV

    CERN Document Server

    Usai, G; Averbeck, R; Banicz, K; Castor, J; Chaurand, B; Cicalò, C; Colla, A; Cortese, P; Damjanovic, S; David, A; De Falco, A; Devaux, A; Drees, A; Ducroux, L; Enyo, H; Ferretti, A; Floris, M; Force, P; Guettet, N; Guichard, A; Gulkanian, H R; Heuser, J; Keil, M; Kluberg, L; Lozano, J; Lourenço, C; Manso, F; Masoni, A; Martins, P; Neves, A; Ohnishi, H; Oppedisano, C; Parracho, P; Pillot, P; Puddu, G; Radermacher, E; Ramalhete, P; Rosinsky, P; Scomparin, E; Seixas, J; Serci, S; Shahoyan, R; Sonderegger, P; Specht, H J; Tieulent, R; Veenhof, R; Wöhri, H K

    2005-01-01

    The NA60 experiment studies open charm and prompt dimuon production in proton-nucleus and nucleus-nucleus collisions at the CERN SPS. During 2003 the experiment collected data in indium-indium collisions at 158 GeV per nucleon. Almost 240 million dimuon events were recorded. New results on J/psi suppression, open-charm production and low mass dimuons should help clarify some interesting questions left open by previous experiments. After a brief detector description, this paper focuses on the analysis of the low mass dimuons. Preliminary results are presented on the phi/omega production cross section ratios and on the phi transverse momentum distributions, both as a function of collision centrality.

  12. J/$\\psi$ suppression in In-In collisions at 158 GeV/nucleon

    CERN Document Server

    Arnaldi, R; Banicz, K; Castor, J; Chaurand, B; Cicalo', C; Colla, A; Cortese, P; Damjanovic, S; David, A; De Falco, A; Devaux, A; Drees, A; Ducroux, L; Enyo, H; Ferretti, A; Floris, M; Förster, A; Force, P; Guettet, N; Guichard, A; Gulkanian, H R; Heuser, J; Keil, M; Kluberg, L; Lourenço, C; Lozano, J; Manso, F; Masoni, A; Martins, P; Neves, A; Ohnishi, H; Oppedisano, C; Parracho, P; Pillot, P; Puddu, G; Radermacher, E; Ramalhete, P; Rosinsky, P; Scomparin, E; Seixas, J; Serci, S; Shahoyan, R; Sonderegger, P; Specht, H J; Tieulent, R; Usai, G; Veenhof, R; Wöhri, H K

    2007-01-01

    The NA60 experiment has studied J/$\\psi$ production in Indium-Indium collisions at 158 A$\\cdot$GeV. In this paper we present an updated set of results obtained with the complete set of available statistics and an improved alignment of the vertex tracker. The centrality dependence of the J/$\\psi$ production, obtained with an analysis technique based only on the J/$\\psi$ sample, indicates that a suppression beyond that induced by nuclear absorption is present in In-In collisions, setting in at $\\sim$80 participant nucleons. A first study of the systematic errors related with this measurement is discussed. We also present preliminary results on the J/$\\psi$ azimuthal distributions.

  13. Hadronic Expansion Dynamics in Central Pb+Pb Collisions at 158 GeV per Nucleon

    CERN Document Server

    Appelshäuser, H; Bailey, S J; Barnby, L S; Bartke, Jerzy; Barton, R A; Bialkowska, H; Billmeier, A; Blyth, C O; Bock, R; Bormann, C; Brady, F P; Brockmann, R; Brun, R; Buncic, P; Caines, H L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Dunn, J; Eckardt, V; Eckhardt, F; Ferguson, M I; Ferenc, D; Fischer, H G; Flierl, D; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Fuchs, M; Gabler, F; Gál, J; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Günther, J; Harris, J W; Hegyi, S; Henkel, T; Hill, L A; Huang, I; Hümmler, H; Igo, G; Irmscher, D; Jacobs, P; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Melkumov, G L; Mock, A; Molnár, J; Nelson, J M; Oldenburg, M; Odyniec, Grazyna Janina; Pálla, G; Panagiotou, A D; Petridis, A; Piper, A; Porter, R J; Poskanzer, A M; Poziombka, S; Prindle, D J; Pühlhofer, F; Rauch, W; Reid, J G; Renfordt, R E; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rudolph, H; Rybicki, A; Sandoval, A; Sann, H; Semenov, A Yu; Schäfer, E; Schmischke, D; Schmitz, N; Schönfelder, S; Seyboth, P; Seyerlein, J; Siklér, F; Skrzypczak, E; Squier, G T A; Stock, Reinhard; Ströbele, H; Struck, C; Szentpétery, I; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Vassiliou, Maria; Vesztergombi, G; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Wienold, T; Wood, L; Yates, T A; Xu, N; Zimányi, J; Zhu, X Z; Zybert, R

    1998-01-01

    Two-particle correlation functions of negative hadrons over wide phase space, and transverse mass spectra of negative hadrons and deuterons near mid-rapidity have been measured in central Pb+Pb collisions at 158 GeV per nucleon by the NA49 experiment at the CERN SPS. A novel Coulomb correction procedure for the negative two-particle correlations is employed making use of the measured oppositely charged particle correlation. Within an expanding source scenario these results are used to extract the dynamic characteristics of the hadronic source, resolving the ambiguities between the temperature and transverse expansion velocity of the source, that are unavoidable when single and two particle spectra are analysed separately. The source shape, the total duration of the source expansion, the duration of particle emission, the freeze-out temperature and the longitudinal and transverse expansion velocities are deduced.

  14. $\\Xi$ and $\\overline{\\Xi}$ production in 158 GeV/nucleon Pb + Pb collisions

    CERN Document Server

    Appelshauser, H.; Bailey, S.J.; Barna, D.; Barnby, L.S.; Bartke, J.; Barton, R.A.; Bialkowska, H.; Billmeier, A.; Blyth, C.O.; Bock, R.; Bormann, C.; Brady, F.P.; Brockmann, R.; Brun, R.; Buncic, P.; Caines, H.L.; Carr, L.D.; Cebra, D.A.; Cooper, G.E.; Cramer, J.G.; Cristinziani, M.; Csato, P.; Dunn, J.; Eckardt, V.; Eckhardt, F.; Ferguson, M.I.; Fischer, H.G.; Flierl, D.; Fodor, Z.; Foka, P.; Freund, P.; Friese, V.; Fuchs, M.; Gabler, F.; Geist, Walter M.; Gal, J.; Gazdzicki, M.; Gladysz, E.; Grebieszkow, J.; Gunther, J.; Harris, J.W.; Hegyi, S.; Henkel, T.; Hill, L.A.; Hummler, H.; Igo, G.; Irmscher, D.; Jacobs, P.; Jones, P.G.; Kadija, K.; Kolesnikov, V.I.; Konashenok, A.; Kowalski, M.; Lasiuk, B.; Levai, P.; Liu, F.; Malakhov, A.I.; Margetis, S.; Markert, C.; Melkumov, G.L.; Mock, A.; Molnar, J.; Nelson, John M.; Oldenburg, M.; Odyniec, G.; Palla, G.; Panagiotou, A.D.; Petridis, A.; Piper, A.; Porter, R.J.; Poskanzer, Arthur M.; Prindle, D.J.; Puhlhofer, F.; Rauch, W.; Reid, J.G.; Renfordt, R.; Retyk, W.; Ritter, H.G.; Rohrich, D.; Roland, C.; Roland, G.; Rudolph, H.; Rybicki, A.; Sandoval, A.; Sann, H.; Semenov, A.Yu.; Schafer, E.; Schmischke, D.; Schmitz, N.; Schonfelder, S.; Seyboth, P.; Seyerlein, J.; Sikler, F.; Skrzypczak, E.; Snellings, R.; Squier, G.T.A.; Stock, R.; Strobele, H.; Struck, C.; Susa, T.; Szentpetery, I.; Sziklai, J.; Toy, M.; Trainor, T.A.; Trentalange, S.; Ullrich, T.; Vassiliou, M.; Veres, G.; Vesztergombi, G.; Vranic, D.; Wang, F.; Weerasundara, D.D.; Wenig, S.; Whitten, C.; Wienold, T.; Wood, L.; Xu, N.; Yates, T.A.; Zimanyi, J.; Zhu, X.Z.; Zybert, R.

    1998-01-01

    We report measurements of Xi and Xi-bar hyperon absolute yields as a function of rapidity in 158 GeV/c Pb+Pb collisions. At midrapidity, dN/dy = 2.29 +/- 0.12 for Xi, and 0.52 +/- 0.05 for Xi-bar, leading to the ratio of Xi-bar/Xi = 0.23 +/- 0.03. Inverse slope parameters fitted to the measured transverse mass spectra are of the order of 300 MeV near mid-rapidity. The estimated total yield of Xi particles in Pb+Pb central interactions amounts to 7.4 +/- 1.0 per collision. Comparison to Xi production in properly scaled p+p reactions at the same energy reveals a dramatic enhancement (about one order of magnitude) of Xi production in Pb+Pb central collisions over elementary hadron interactions.

  15. High-multiplicity lead-lead interactions at 158 GeV/{ital c} per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Deines-Jones, P.; Cherry, M.L.; Dabrowska, A.; Holynski, R.; Jones, W.V.; Kolganova, E.D.; Kudzia, D.; Nilsen, B.S.; Olszewski, A.; Pozharova, E.A.; Sengupta, K.; Szarska, M.; Trzupek, A.; Waddington, C.J.; Wefel, J.P.; Wilczynska, B.; Wilczynski, H.; Wolter, W.; Wosiek, B.; Wozniak, K. [Louisiana State University, Baton Rouge, Louisiana Institute of Nuclear Physics, Krakow, Poland Institute of Theoretical and Experimental Physics, Moscow, Russia University of Minnesota, Minneapolis, Minnesota (United States)

    1996-06-01

    The Krakow-Louisiana-Minnesota-Moscow Collaboration (KLMM) has exposed a set of emulsion chambers with lead targets to a 158 GeV/{ital c} per nucleon beam of {sup 208}Pb nuclei, and we report the initial analysis of 40 high-multiplicity Pb-Pb collisions. To test the validity of the superposition model of nucleus-nucleus interactions in this new regime, we compare the shapes of the pseudorapidity distributions with FRITIOF Monte Carlo model calculations, and find close agreement for even the most central events. We characterize head-on collisions as having a mean multiplicity of 1550{plus_minus}120 and a peak pseudorapidity density of 390{plus_minus}30. These estimates are significantly lower than our FRITIOF calculations. {copyright} {ital 1996 The American Physical Society.}

  16. High-Multiplicity Lead-Lead Interactions at 158 GeV/c per nucleon

    Science.gov (United States)

    Deines-Jones, P.; Cherry, M. L.; Dabrowska, A.; Holynski, R.; Jones, W. V.; Kolganova, E. D.; Kudzia, D.; Nilsen, B. S.; Olszewski, A.; Pozharova, E. A.; hide

    1996-01-01

    The Krakow-Louisiana-Minnesota-Moscow Collaboration (KLMM) has exposed a set of emulsion chambers with lead targets to a 158 GeV/c per nucleon beam of Pb-208 nuclei, and we report the initial analysis of 40 high-multiplicity Pb-Pb collisions. To test the validity of the superposition model of nucleus-nucleus interactions in this new regime, we compare the shapes of the pseudorapidity distributions with FRITIOF Monte Carlo model calculations, and find close agreement for even the most central events. We characterize head-on collisions as having a mean multiplicity of 1550 +/- 120 and a peak pseudorapidity density of 390 +/- 30. These estimates are significantly lower than our FRITIOF calculations.

  17. Association study between COMT 158Met and creativity scores in bipolar disorder and healthy controls

    Directory of Open Access Journals (Sweden)

    Márcio Gerhardt Soeiro-de-Souza

    2014-03-01

    Full Text Available Background Bipolar disorder (BD patients have been reported to be associated higher creativity abilities, and recent data tend to support the hypothesis that dopaminergic system that could be associated with creativity. Catechol-O-methyltransferase (COMT is one of the major enzymes involved in the metabolic degradation of dopamine. The COMT gene polymorphism (rs4680 or Val158Met Met allele is reported to cause decreased activity of this enzyme in prefrontal cortex and improve performance in several cognitive domains. Objective The objective of this study was to evaluate the influence of Val158Met on creativity in BD type I and healthy controls. Methods Ninety-seven healthy volunteers and 120 BD type I were genotyped for COMT rs4680 and tested for creativity (Barrow Welsh Art Scale – BWAS and intelligence Wechsler Abbreviated Scale of Intelligence (WASI. Results COMT Met allele positively influenced creativity scores in healthy controls but not in BD subjects during mood episodes and euthymia. The presence of allele Met did not influence IQ scores. No influence of IQ total score on creativity was observed. Limitations control group presented higher IQ scores and euthymic group was under medication use. Discussion Our research suggests positive effect of COMT rs4680 (allele Met on creativity scores in healthy controls. One possible interpretation is that creativity is more likely to be associated with lesser degrees of bipolarity. The fact that the same results were not observed in BD may be associated to dysfunctions in the dopaminergic system that characterizes this disorder. Further studies with larger samples and other types of BD should explore the role of the dopaminergic system in creativity.

  18. COMT val158met and 5-HTTLPR genetic polymorphisms moderate executive control in cannabis users.

    Science.gov (United States)

    Verdejo-García, Antonio; Fagundo, Ana Beatriz; Cuenca, Aida; Rodriguez, Joan; Cuyás, Elisabet; Langohr, Klaus; de Sola Llopis, Susana; Civit, Ester; Farré, Magí; Peña-Casanova, Jordi; de la Torre, Rafael

    2013-07-01

    The adverse effects of cannabis use on executive functions are still controversial, fostering the need for novel biomarkers able to unveil individual differences in the cognitive impact of cannabis consumption. Two common genetic polymorphisms have been linked to the neuroadaptive impact of Δ9-tetrahydrocannabinol (THC) exposure and to executive functions in animals: the catechol-O-methyltransferase (COMT) gene val158met polymorphism and the SLC6A4 gene 5-HTTLPR polymorphism. We aimed to test if these polymorphisms moderate the harmful effects of cannabis use on executive function in young cannabis users. We recruited 144 participants: 86 cannabis users and 58 non-drug user controls. Both groups were genotyped and matched for genetic makeup, sex, age, education, and IQ. We used a computerized neuropsychological battery to assess different aspects of executive functions: sustained attention (CANTAB Rapid Visual Information Processing Test, RVIP), working memory (N-back), monitoring/shifting (CANTAB ID/ED set shifting), planning (CANTAB Stockings of Cambridge, SOC), and decision-making (Iowa Gambling Task, IGT). We used general linear model-based analyses to test performance differences between cannabis users and controls as a function of genotypes. We found that: (i) daily cannabis use is not associated with executive function deficits; and (ii) COMT val158met and 5-HTTLPR polymorphisms moderate the link between cannabis use and executive performance. Cannabis users carrying the COMT val/val genotype exhibited lower accuracy of sustained attention, associated with a more strict response bias, than val/val non-users. Cannabis users carrying the COMT val allele also committed more monitoring/shifting errors than cannabis users carrying the met/met genotype. Finally, cannabis users carrying the 5-HTTLPR s/s genotype had worse IGT performance than s/s non-users. COMT and SLC6A4 genes moderate the impact of cannabis use on executive functions.

  19. Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis.

    Science.gov (United States)

    Mata, Ignacio; Perez-Iglesias, Rocio; Pelayo-Teran, Jose Maria; Rodríguez-Sanchez, Jose Manuel; Gonzalez-Blanch, Cesar; Carrasco-Marin, Eugenio; Vazquez-Barquero, Jose Luis; Crespo-Facorro, Benedicto

    2008-07-01

    COMT gene is a logical candidate gene for schizophrenia. Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefrontal cognitive abnormalities among patients with schizophrenia, healthy relatives and controls. In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis. We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt.

  20. Selective Sensing of Fe(3+) and Al(3+) Ions and Detection of 2,4,6-Trinitrophenol by a Water-Stable Terbium-Based Metal-Organic Framework.

    Science.gov (United States)

    Cao, Li-Hui; Shi, Fang; Zhang, Wen-Min; Zang, Shuang-Quan; Mak, Thomas C W

    2015-10-26

    A water-stable luminescent terbium-based metal-organic framework (MOF), {[Tb(L1 )1.5 (H2 O)]⋅3 H2 O}n (Tb-MOF), with rod-shaped secondary building units (SBUs) and honeycomb-type tubular channels has been synthesized and structurally characterized by single-crystal X-ray diffraction. The high green emission intensity and the microporous nature of the Tb-MOF indicate that it can potentially be used as a luminescent sensor. In this work, we show that Tb-MOF can selectively sense Fe(3+) and Al(3+) ions from mixed metal ions in water through different detection mechanisms. In addition, it also exhibits high sensitivity for 2,4,6-trinitrophenol (TNP) in the presence of other nitro aromatic compounds in aqueous solution by luminescence quenching experiments. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Central Pb plus Pb collisions at 158 A GeV/c studied by pi(-)pi(-) interferometry

    NARCIS (Netherlands)

    Aggarwal, MM; Agnihotri, A; Ahammed, Z; Angelis, ALS; Antonenko, [No Value; Arefiev, [No Value; Astakhov, [No Value; Avdeitchikov, [No Value; Awes, TC; Baba, PVKS; Badyal, SK; Barlag, C; Bathe, S; Batiounia, B; Bernier, T; Bhalla, KB; Bhatia, VS; Blume, C; Bock, R; Bohne, EM; Borocz, Z; Bucher, D; Buijs, A; Busching, H; Carlen, L; Chalyshev, [No Value; Chattopadhyay, S; Cherbatchev, R; Chujo, T; Claussen, A; Das, AC; Decowski, MP; Delagrange, H; Djordjadze, [No Value; Donni, P; Doubovik, [No Value; Dutt, S; Majumdar, MRD; El Chenawi, K; Eliseev, S; Enosawa, K; Foka, P; Fokin, S; Ganti, MS; Garpman, S; Gavrishchuk, O; Geurts, FJM; Ghosh, TK; Glasow, R; Gupta, SK; Guskov, B; Gustafsson, H.A.; Gutbrod, HH; Higuchi, R; Hrivnacova, [No Value; Ippolitov, M; Kalechofsky, H; Kamermans, R; Kampert, KH; Karadjev, K; Karpio, K; Kato, S; Kees, S; Klein-Bosing, C; Knoche, S; Kolb, BW; Kosarev, [No Value; Koutcheryaev, [No Value; Krumpel, T; Kugler, A; Kulinich, P; Kurata, M; Kurita, K; Kuzmin, N; Langbein, [No Value; Lebedev, A; Lee, YY; Löhner, H.; Luquin, L; Mahapatra, DP; Manko, [No Value; Martin, M; Martinez, G; Maximov, A; Mgebrichvili, G; Miake, Y; Mir, MF; Mishra, GC; Miyamoto, Y; Mohanty, B; Morrison, D; Mukhopadhyay, DS; Naef, H; Nandi, BK; Nayak, SK; Nayak, TK; Neumaier, S; Nianine, A; Nikitine, [No Value; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, P; Nystrand, J; Obenshain, FE; Oskarsson, A; Otterlund, [No Value; Pachr, M; Pavliouk, S; Peitzmann, T; Petracek, [No Value; Pinganaud, W; Plasil, F; von Poblotzki, U; Purschke, ML; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, VS; Rao, NK; Retiere, F; Reygers, K; Roland, G; Rosselet, L; Roufanov, [No Value; Roy, C; Rubio, JM; Sako, H; Sambyal, SS; Santo, R; Sato, S; Schlagheck, H; Schutz, Y; Shabratova, G; Shah, TH; Sibiriak, [No Value; Siemiarczuk, T; Silvermyr, D; Sinha, BC; Slavine, N; Soderstrom, K; Solomey, N; Sorensen, SP; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stuken, D; Sumbera, M; Svensson, T; Trivedi, MD; Tsvetkov, A.; Tykarski, L; Urbahn, J; vander Pijll, EC; von Eijndhoven, N; von Nieuwenhuizen, GJ; Vinogradov, A; Viyogi, YP; Vodopianov, A; Voros, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, GR

    Two-particle correlations have been measured for identified pi(-) from central 158 A GeV Pb+Pb collisions and fitted radii of about 7 fm in all dimensions have been obtained. A multi-dimensional study of the radii as a function of k(gamma) is presented, including a full correction for the resolution

  2. Elliptic emission of K+ and pi(+) in 158 A center dot GeV Pb + Pb collisions

    NARCIS (Netherlands)

    Aggarwal, MM; Agnihotri, A; Ahammed, Z; Angelis, ALS; Antonenko, [No Value; Arefiev, [No Value; Astakhov, [No Value; Avdeitchikov, [No Value; Awes, TC; Baba, PVKS; Badyal, SK; Baldine, A; Barabach, L; Barlag, C; Bathe, S; Batiounia, B; Bernier, T; Bhalla, KB; Bhatia, VS; Blume, C; Bock, R; Bohne, EM; Borocz, Z; Bucher, D; Buijs, A; Busching, H; Carlen, L; Chalyshev, [No Value; Chattopadhyay, S; Cherbatchev, R; Chujo, T; Claussen, A; Das, AC; Decowski, MP; Delagrange, H; Djordjadze, [No Value; Donni, P; Doubovik, [No Value; Dutt, S; Majumdar, MRD; El Chenawi, K; Eliseev, S; Enosawa, K; Foka, P; Fokin, S; Frolov, [No Value; Ganti, MS; Garpman, S; Gavrishchuk, O; Geurts, FJM; Ghosh, TK; Glasow, R; Gupta, SK; Guskov, B; Gustafsson, H.A.; Gutbrod, HH; Higuchi, R; Hrivnacova, [No Value; Ippolitov, M; Kalechofsky, H; Kamermans, R; Kampert, KH; Karadjev, K; Karpio, K; Kato, S; Kees, S; Kolb, BW; Kosarev, [No Value; Koutcheryaev, [No Value; Krumpel, T; Kugler, A; Kulinich, P; Kurata, M; Kurita, K; Kuzmin, N; Langbein, [No Value; Lebedev, A; Lee, YY; Lohner, H; Luquin, L; Mahapatra, DP; Manko, [No Value; Martin, M; Martinez, G; Maximov, A; Mehdiyev, R; Mgebrichvili, G; Miake, Y; Mikhalev, D; Mir, MF; Mishra, GC; Miyamoto, Y; Morrison, D; Mohanty, B; Mukhopadhyay, DS; Myalkovski, [No Value; Naef, H; Nandi, BK; Nayak, SK; Nayak, TK; Neumaier, S; Nianine, A; Nikitine, [No Value; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, P; Nystrand, J; Obenshain, FE; Oskarsson, A; Otterlund, [No Value; Pachr, M; Parfenov, A; Pavliouk, S; Peitzmann, T; Petracek, [No Value; Plasil, F; Pinganaud, W; Purschke, ML; Raeven, B; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, VS; Rao, NK; Retiere, F; Reygers, K; Roland, G; Rosselet, L; Roufanov, [No Value; Roy, C; Rubio, JM; Sako, H; Sambyal, SS; Santo, R; Sato, S; Schlagheck, H; Schutz, Y; Shabratova, G; Shah, TH; Sibiriak, [No Value; Siemiarczuk, T; Silvermyr, D; Sinha, BC; Salvine, N; Soderstrom, K; Solomey, N; Sorensen, SP; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stuken, D; Sumbera, M; Svensson, T; Trivedi, MD; Tsvetkov, A.; Tykarski, L; Urbahn, J; vander Pijll, EC; von Eijndhoven, N; von Nieuwenhuizen, GJ; Vinogradov, A; Viyogi, YP; Vodopianov, A; Voros, S; Wyslouch, B; Yagi, K; Yokota, Y

    1999-01-01

    An event-by-event analysis of the azimuthal angular correlation with respect to the reaction plane has been carried out for K+ and pi(+) emission near mid-rapidity in 158 A . GeV Pb + Pb collisions. In semi-central collisions, K+ mesons are found to be preferentially emitted out of the reaction

  3. 77 FR 40692 - 30-Day Notice of Proposed Information Collection: DS-158, Contact Information and Work History...

    Science.gov (United States)

    2012-07-10

    ... Notice of Proposed Information Collection: DS-158, Contact Information and Work History for Nonimmigrant... collection request to the Office of Management and Budget (OMB) for approval in accordance with the Paperwork Reduction Act of 1995. Title of Information Collection: Contact Information and Work History for...

  4. Three-Pion Interferometry Results from Central Pb+Pb Collisions at 158 A GeV/c

    CERN Document Server

    Aggarwal, M M; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bock, R; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Delagrange, H; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S K; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Klein-Bösing, C; Knoche, S; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Martínez, G; Maksimov, A; Mgebrishvili, G; Miake, Y; Mir, M F; Mishra, G C; Miyamoto, Y; Mohanty, B; Mora, M J; Morrison, D; Mukhopadhyay, D S; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Pinganaud, W; Plasil, F; Von Poblotzki, U; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Tykarski, L; Urbahn, J; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    2000-01-01

    Three-particle correlations have been measured for identified negative pions from central 158 A GeV Pb+Pb collisions by the WA98 experiment at CERN. A substantial contribution of the genuine three-body correlation has been found as expected for a mainly chaotic and symmetric source.

  5. Physicochemical Parameters for Growth of the Sea Ice Bacteria Glaciecola punicea ACAM 611T and Gelidibacter sp. Strain IC158

    Science.gov (United States)

    Nichols, D. S.; Greenhill, A. R.; Shadbolt, C. T.; Ross, T.; McMeekin, T. A.

    1999-01-01

    The water activity and pH ranges for growth of Glaciecola punicea (a psychrophile) were extended when this organism was grown at suboptimal rather than optimal temperatures. No such extension was observed for Gelidibacter sp. strain IC158 (a psychrotolerant bacterium) at analogous temperatures. Salinity and pH may be primary physicochemical parameters controlling bacterial community development in sea ice. PMID:10427082

  6. 77 FR 17012 - Foreign-Trade Zone 158-Vicksburg/Jackson, MS; Application for Manufacturing Authority; Morgan...

    Science.gov (United States)

    2012-03-23

    ....90; duty free) would be shipped from the zone to U.S. furniture manufacturing plants where they would... Foreign-Trade Zones Board Foreign-Trade Zone 158--Vicksburg/Jackson, MS; Application for Manufacturing Authority; Morgan Fabrics Corporation (Upholstered Furniture Covering Sets), Verona, MS An application has...

  7. Measured thermal and fast neutron fluence rates for ATF-1 holders during ATR cycle 158B/159A

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States); Walker, Billy Justin [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-11-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 158B/159A which were measured by the Radiation Measurements Laboratory (RML).

  8. 77 FR 12903 - 60-Day Notice of Proposed Information Collection: DS-158, Contact Information and Work History...

    Science.gov (United States)

    2012-03-02

    ... Notice of Proposed Information Collection: DS-158, Contact Information and Work History for Nonimmigrant... of Information Collection: Contact Information and Work History for Nonimmigrant Visa Applicant. OMB... access to the Internet may view and comment on this notice by going to the Federal regulations Web site...

  9. Catechol-O-methyltransferase Val158met polymorphism interacts with early experience to predict executive functions in early childhood.

    Science.gov (United States)

    Blair, Clancy; Sulik, Michael; Willoughby, Michael; Mills-Koonce, Roger; Petrill, Stephen; Bartlett, Christopher; Greenberg, Mark

    2015-11-01

    Numerous studies demonstrate that the Methionine variant of the catechol-O-methyltransferase Val158Met polymorphism, which confers less efficient catabolism of catecholamines, is associated with increased focal activation of prefrontal cortex (PFC) and higher levels of executive function abilities. By and large, however, studies of COMT Val158Met have been conducted with adult samples and do not account for the context in which development is occurring. Effects of early adversity on stress response physiology and the inverted U shape relating catecholamine levels to neural activity in PFC indicate the need to take into account early experience when considering relations between genes such as COMT and executive cognitive ability. Consistent with this neurobiology, we find in a prospective longitudinal sample of children and families (N = 1292) that COMT Val158Met interacts with early experience to predict executive function abilities in early childhood. Specifically, the Valine variant of the COMT Val158Met polymorphism, which confers more rather than less efficient catabolism of catecholamines is associated with higher executive function abilities at child ages 48 and 60 months and with faster growth of executive function for children experiencing early adversity, as indexed by cumulative risk factors in the home at child ages 7, 15, 24, and 36 months. Findings indicate the importance of the early environment for the relation between catecholamine genes and developmental outcomes and demonstrate that the genetic moderation of environmental risk is detectable in early childhood. © 2015 Wiley Periodicals, Inc.

  10. Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism.

    Science.gov (United States)

    Inanir, Ahmet; Karakus, Nevin; Ates, Omer; Sezer, Saime; Bozkurt, Nihan; Inanir, Sema; Yigit, Serbulent

    2014-10-01

    1. Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. The aim of this study was to explore the frequency and clinical significance of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in a large cohort of Turkish patients with FMS. 2. The study included 379 FMS patients and 290 controls. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses. 3. The genotype frequencies of Val158Met polymorphism showed a small difference between FMS patients and healthy controls (p = 0.047), however, the Met/Met genotype was significantly higher in FMS patients than healthy controls (p = 0.016). No difference was observed for allele frequencies between two groups. Stratification analysis according to clinical features for this disease reveals that weight, FMS Impact Questionnaire score, algometry and Raynaud's syndrome, were detected to have statistically significant associations with Val158Met polymorphism (p = 0.037, p = 0.042, p = 0.039 and p = 0.033, respectively). Pain sensitivity, measured by algometry, was statistically higher in patients with Met/Met genotype than the patients with Val/Val and Val/Met genotypes (p = 0.017). 4. The results of this study suggested that COMT gene Val158Met polymorphism is positively associated with FMS and play a relevant role in the clinical symptoms of the disease.

  11. Modification of Depression by COMT val[superscript 158]Met Polymorphism in Children Exposed to Early Severe Psychosocial Deprivation

    Science.gov (United States)

    Drury, Stacy S.; Theall, Katherine P.; Smyke, Anna T.; Keats, Bronya J. B.; Egger, Helen L.; Nelson, Charles A.; Fox, Nathan A.; Marshall, Peter J.; Zeanah, Charles H.

    2010-01-01

    Objective: To examine the impact of the catechol-O-methyltransferase (COMT) val[superscript 158]met allele on depressive symptoms in young children exposed to early severe social deprivation as a result of being raised in institutions. Methods: One hundred thirty six children from the Bucharest Early Intervention Project (BEIP) were randomized…

  12. A new measurement of $J/\\psi$ suppression in Pb-Pb collisions at 158 GeV per nucleon

    National Research Council Canada - National Science Library

    Alessandro, B; Alexa, C; Arnaldi, R; Atayan, M; Beolè, S; Boldea, V; Bordalo, P; Borges, G; Castanier, C; Castor, J; Chaurand, B; Cheynis, B; Chiavassa, E; Cicalo, C; Comets, M.P; Constantinescu, S; Cortese, P; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Fargeix, J; Force, P; Gallio, M; Gerschel, C; Giubellino, P; Golubeva, M.B; Gonin, M; Grigoryan, A; Grigoryan, S; Guber, F.F; Guichard, A; Gulkanyan, H; Idzik, M; Jouan, D; Karavicheva, T.L; Kluberg, L; Kurepin, A.B; Le Bornec, Y; Lourenço, C; Mac Cormick, M; Macciotta, P; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J.-R; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N.S; Usai, G.L; Vercellin, E; Villatte, L; Willis, N; Wu, T

    2005-01-01

    We present a new measurement of $J/\\psi$ production in Pb-Pb collisions at 158 GeV/nucleon, from the data sample collected in year 2000 by the NA50 Collaboration, under improved experimental conditions with respect to previous years...

  13. The Feasibility Study of Implementing a Fiber Optic Local Area Network in Software Metrics Laboratory in Ingersoll 158

    National Research Council Canada - National Science Library

    Be, Chai

    2004-01-01

    ... fiber components compared to the increase electronic costs of carrying Gigabit Ethernet over Cat 5 or Cat SE UTP copper cabling has also accelerated the migration to optical fiber LAN. The thesis conducts a feasibility study of implementing a Fiber Optic Local Area Network in Software Metrics Laboratory in Ingersoll 158.

  14. Picomolar traces of americium(III) introduce drastic changes in the structural chemistry of terbium(III). A break in the ''gadolinium break''

    Energy Technology Data Exchange (ETDEWEB)

    Welch, Jan M. [TU Wien, Atominstitut, Vienna (Austria); Mueller, Danny; Knoll, Christian; Wilkovitsch, Martin; Weinberger, Peter [TU Wien, Institute of Applied Synthetic Chemistry, Vienna (Austria); Giester, Gerald [University of Vienna, Institute of Mineralogy and Crystallography, Vienna (Austria); Ofner, Johannes; Lendl, Bernhard [TU Wien, Institute of Chemical Technologies and Analytics, Vienna (Austria); Steinhauser, Georg [Leibniz Universitaet Hannover, Institute of Radioecology and Radiation Protection (Germany)

    2017-10-16

    The crystallization of terbium 5,5{sup '}-azobis[1H-tetrazol-1-ide] (ZT) in the presence of trace amounts (ca. 50 Bq, ca. 1.6 pmol) of americium results in 1) the accumulation of the americium tracer in the crystalline solid and 2) a material that adopts a different crystal structure to that formed in the absence of americium. Americium-doped [Tb(Am)(H{sub 2}O){sub 7}ZT]{sub 2} ZT.10 H{sub 2}O is isostructural to light lanthanide (Ce-Gd) 5,5{sup '}-azobis[1H-tetrazol-1-ide] compounds, rather than to the heavy lanthanide (Tb-Lu) 5,5{sup '}-azobis[1H-tetrazol-1-ide] (e.g., [Tb(H{sub 2}O){sub 8}]{sub 2}ZT{sub 3}.6 H{sub 2}O) derivatives. Traces of Am seem to force the Tb compound into a structure normally preferred by the lighter lanthanides, despite a 10{sup 8}-fold Tb excess. The americium-doped material was studied by single-crystal X-ray diffraction, vibrational spectroscopy, radiochemical neutron activation analysis, and scanning electron microscopy. In addition, the inclusion properties of terbium 5,5{sup '}-azobis[1H-tetrazol-1-ide] towards americium were quantified, and a model for the crystallization process is proposed. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  15. Association of Catechol-O-methyltransferase polymorphism Val158Met and mammographic density: A meta-analysis.

    Science.gov (United States)

    Kallionpää, Roope A; Uusitalo, Elina; Peltonen, Juha

    2017-08-15

    The Val158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. High mammographic density is a known risk factor of breast cancer. Our aim was to perform meta-analysis of the effect of COMT Val158Met polymorphism on mammographic density. Original studies reporting data on mammographic density, stratified by the presence of COMT Val158Met polymorphism, were identified and combined using genetic models Met/Val vs. Val/Val, Met/Met vs. Val/Val, Val/Met+Met/Met vs. Val/Val (dominant model) and Met/Met vs. Val/Met+Val/Val (recessive model). Subgroup analyses by breast cancer status, menopausal status and use of hormone replacement therapy (HRT) were also performed. Eight studies were included in the meta-analysis. The overall effect in percent mammographic density was -1.41 (CI -2.86 to 0.05; P=0.06) in the recessive model. Exclusion of breast cancer patients increased the effect size to -1.93 (CI -3.49 to -0.37; P=0.02). The results suggested opposite effect of COMT Val158Met for postmenopausal users of HRT versus premenopausal women or postmenopausal non-users of HRT. COMT Val158Met polymorphism may be associated with mammographic density at least in healthy women. Menopausal status and HRT should be taken into account in future studies to avoid masking of the underlying effects. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.

    Directory of Open Access Journals (Sweden)

    Jay P Singh

    Full Text Available We conducted a meta-analysis of studies examining the association between the Val158Met COMT polymorphism and violence against others in schizophrenia. A systematic search current to November 1, 2011 was conducted using MEDLINE, EMBASE, CINAHL, PsycINFO, ProQuest, and the National Criminal Justice Reference Service and identified 15 studies comprising 2,370 individuals with schizophrenia for inclusion. Bivariate analyses of study sensitivities and specificities were conducted. This methodology allowed for the calculation of pooled diagnostic odds ratios (DOR. Evidence of a significant association between the presence of a Met allele and violence was found such that men's violence risk increased by approximately 50% for those with at least one Met allele compared with homozygous Val individuals (DOR = 1.45; 95% CI = 1.05-2.00; z = 2.37, p = 0.02. No significant association between the presence of a Met allele and violence was found for women or when outcome was restricted to homicide. We conclude that male schizophrenia patients who carry the low activity Met allele in the COMT gene are at a modestly elevated risk of violence. This finding has potential implications for the pharmacogenetics of violent behavior in schizophrenia.

  17. $\\phi$ Production in In-In Collisions at 158 A GeV

    CERN Document Server

    Arnaldi, R; Borer, K; Castor, J; Chaurand, B; Chen, W; Cicalò, C; Colla, A; Cortese, P; Damjanovic, S; David, A; de Falco, A; Devaux, A; Ducroux, L; En’yo, H; Fargeix, J; Ferretti, A; Floris, M; Förster, A; Force, P; Guettet, N; Guichard, A; Gulkanyan, H; Heuser, J; Keil, M; Kluberg, L; Li, Z; Lourenço, C; Lozano, J; Manso, F; Martins, P; Masoni, A; Neves, A; Ohnishi, H; Oppedisano, C; Parracho, P; Pillot, P; Poghosyan, T; Puddu, G; Radermacher, E; Ramalhete, P; Rosinsky, P; Scomparin, E; Seixas, J; Serci, S; Shahoyan, R; Sonderegger, P; Specht, H J; Tieulent, R; Uras, A; Usai, G; Veenhof, R; Wöhri, H K

    2009-01-01

    The NA60 experiment has measured muon pair production in In-In collisions at 158 AGeV at the CERN SPS. This paper presents a high statistics measurement of $\\phi\\to\\mu\\mu$ meson production. Differential spectra, yields, mass and width are measured as a function of centrality and compared to previous measurements in other colliding systems at the same energy. The width of the rapidity distribution is found to be constant as a function of centrality, compatible with previous results. The decay muon polar angle distribution is measured in several reference frames. No evidence of polarization is found as a function of transverse momentum and centrality. The analysis of the $p_{T}$ spectra shows that the $\\phi$ has a small radial flow, implying a weak coupling to the medium. The $T_{eff}$ parameter measured in In-In collisions suggests that the high value observed in Pb-Pb in the kaon channel is difficult to reconcile with radial flow alone. The absolute yield is compared to results in Pb-Pb collisions: though sig...

  18. BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms.

    Science.gov (United States)

    Ehsani, Laleh; Seth, Rishie; Bacopulos, Stephanie; Seth, Arun; Osunkoya, Adeboye O

    2013-04-01

    The distinction between renal oncocytoma and renal cell carcinoma, especially chromophobe renal cell carcinoma and clear cell carcinoma with oncocytic features, is important due to the different biologic potentials of these tumors. RING E3 ligases have the subject of intense studies for their roles in many diseases including cancer and as potential therapeutic targets. All RING E3 ligases, including BCA2, contain a consensus protein sequence that would complex two or more zinc ions in the expressed protein. Identification of which ubiquitin ligases specifically affect distinct cellular processes is essential to the development of targeted therapeutics in these tumors. The ubiquitin-proteasome system regulates the turnover of proteins that have essential roles in the cell cycle, apoptosis, DNA damage repair, and in protein trafficking, which makes this pathway a target for oncogenic events. In this study, we investigated expression of BCA2 in renal oncocytoma and renal cell carcinoma. A total of 158 patients were included in the study. Our study has shown that 114/114 (100 %) cases of renal cell carcinoma were negative for BCA2. All 38 (100 %) cases of renal oncocytoma were positive for BCA2, and 6/6 (100 %) cases designated as oncocytic neoplasm which favor oncocytoma were also positive for BCA2. This is the first study to date evaluating the expression of BCA2 in renal oncocytoma. BCA2 could serve as a marker that may be utilized in the distinction between renal oncocytoma and its mimickers.

  19. Investigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism

    Science.gov (United States)

    Frenzel, Clemens; Walter, Nora T.; Markett, Sebastian; Montag, Christian

    2011-01-01

    Findings from twin studies yield heritability estimates of 0.50 for prosocial behaviours like empathy, cooperativeness and altruism. First molecular genetic studies underline the influence of polymorphisms located on genes coding for the receptors of the neuropeptides, oxytocin and vasopressin. However, the proportion of variance explained by these gene loci is rather low indicating that additional genetic variants must be involved. Pharmacological studies show that the dopaminergic system interacts with oxytocin and vasopressin. The present experimental study tests a dopaminergic candidate polymorphism for altruistic behaviour, the functional COMT Val158Met SNP. N = 101 healthy Caucasian subjects participated in the study. Altruism was assessed by the amount of money donated to a poor child in a developing country, after having earned money by participating in two straining computer experiments. Construct validity of the experimental data was given: the highest correlation between the amount of donations and personality was observed for cooperativeness (r = 0.32, P ≤ 0.001). Carriers of at least one Val allele donated about twice as much money as compared with those participants without a Val allele (P = 0.01). Cooperativeness and the Val allele of COMT additively explained 14.6% of the variance in donation behaviour. Results indicate that the Val allele representing strong catabolism of dopamine is related to altruism. PMID:21030481

  20. Strange particle production in proton-proton collisions at 158 GeV

    CERN Document Server

    Barna, Daniel

    A new experimen tal procedure to reconstruct neutral strange particles (so-called V 0 s, like §, §) and multiply strange particles ( cascades , like • ° and ≠ ° ) in the NA49 experimen t at the CERN SPS is presen ted in this thesis, together with the results obtained by this metho d in proton-proton collisions at 158 GeV beam energy . The NA49 experimen t, its detector system and reconstruction software is brie∞y describ ed. The way from the detector signals to reconstructed particle trajectories is ex- plained, with special emphasis on V 0 and cascade reconstruction. The newly developed procedure is presen ted together with another metho d. These two metho ds are com- pared, and their performance is studied in detail. Argumen ts for the need of the newly developed procedure (and for the need of two indep enden t metho ds) are given. The results of my work, presen ted in this thesis (obtained by combining the results of the two separate metho ds) are as follows: ≤ Inclusiv e longitudinal and tran...

  1. Model shape and spin direction of the asteroid 2011 UW158

    Science.gov (United States)

    Silva, José; Monteiro, Filipe; Tamayo, Francisco

    2017-10-01

    We determinate the spin direction and convex model shape of the Near Earth Asteroid 2011 UW158 using the lightcurves from the Minor Planet Center database and obtained from the San Pedro Mártir observatory (Ensenada, Baja California, Mexico) and the Observatório Astronômico do Sertão de Itaparica (Itacuruba, Pernambuco, Brazil) by mean of the light-curve inversion technique.The shape model was compared with the radar images obtained from the 230-foot-wide Deep Space Network antenna at Goldstone, California, in concert with the National Radio Astronomy Observatory's 330-foot Green Bank Telescope in July 2015 and with the spin direction published for Carbognani et. al (2016).We found that the spin direction given for Carbognani et al. does not correspond with the visual geometry observed from the radar images. Also, we try to minimize the number of lightcurves that reproduce the shape in a robust way, with the objective of to plan future observations of asteroids better and prioritize time.

  2. No association of COMT (Val158Met genotype with brain structure differences between men and women.

    Directory of Open Access Journals (Sweden)

    Anna Barnes

    Full Text Available We examined the effect of the catechol-O-methyltransferase (COMT Val158Met polymorphism (rs4680, on brain structure in a subset (N = 82 of general population members of the Northern Finland 1966 Birth Cohort, selected through a randomization procedure, aged 33-35. Optimised voxel-based morphometry was used to produce grey matter maps from each subject's high resolution T1 weighted brain magnetic resonance images, which were subsequently entered into a general linear model with COMT genotype as defined by Met allele loading, gender and genotype by gender interaction as independent variables. Additional analyses were carried out on grey matter volumes within the dorsal lateral pre-frontal cortex (DLPFC to examine effects on overall DLPFC volume and also using the DLPFC as a mask for voxelwise analyses, as this is an area previously reported as associated with Met allele loading. We failed to find any statistically significant association with grey matter volume and Met allele loading in the COMT gene or interaction affects between COMT and gender in either the whole brain voxel-wise analysis or in the area of the DLPFC.

  3. Deuteron production in central Pb+Pb collisions at 158A GeV

    CERN Document Server

    Afanasiev, S V; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Blyth, C O; Boimska, B; Bracinik, J; Brady, F P; Brun, R; Buncic, P; Carr, L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Eckardt, V; Eckhardt, F; Ferenc, D; Fischer, H G; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Ftácnik, J; Gál, J; Ganz, R E; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Harris, J W; Hegyi, S; Hlinka, V; Höhne, C; Igo, G; Ivanov, M; Jacobs, P; Janik, R; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Mayes, B W; Melkumov, G L; Mischke, A; Molnár, J; Nelson, J M; Odyniec, Grazyna Janina; Oldenburg, M; Pálla, G; Panagiotou, A D; Petridis, A; Pikna, M; Pinsky, L; Poskanzer, A M; Prindle, D J; Pühlhofer, F; Reid, J G; Renfordt, R E; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rybicki, A; Sammer, T; Sandoval, A; Sann, H; Semenov, A Yu; Schäfer, E; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Snellings, R; Squier, G T A; Stock, Reinhard; Strmen, P; Ströbele, H; Struck, C; Susa, T; Szarka, I; Szentpétery, I; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Voloshin, S A; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Xu, N; Yates, T A; Yoo, I K; Zimányi, J

    2000-01-01

    Experimental results on deuteron emission from central Pb+Pb collisions (E/sub beam/=158A GeV, fixed target), obtained by NA49 at the CERN SPS accelerator, are presented. The transverse mass m/sub t/ distribution was measured near mid-rapidity (2.0

  4. Fragmentation of the Pb projectile at 158 GeV/nucleon an Pb-Pb interactions

    Energy Technology Data Exchange (ETDEWEB)

    Cherry, M.L.; Deines-Jones, P. [Louisiana State University, Baton Rouge (United States); Dabrowska, A. [Institute of Nuclear Physics, Cracow (Poland)] [and others; KLM Collaboration

    1998-08-01

    We have investigated the process of fragmentation of the Pb nucleus at 158 GeV/nucleon in Pb-Pb interactions recorded in lead-emulsion chambers of the EMU13 CERN experiment. The number of Pb-Pb interactions found was larger than that expected from the nuclear charge changing cross section which indicates an important role of electromagnetic dissociation processes in Pb-Pb interactions at this high energy. The emission angles of multiply charged projectile fragments as well as of spectator protons were measured using the semiautomated device with the CCD camera mounted on a microscope. Taking the advantage of the unconventional design of the emulsion chambers the charges of all multiply charged projectile fragments were measured. On the basis of these measurements, different modes of the Pb projectile break-up are discussed. The rates and properties of the fragmentation processes such as fission, multifragmentation and disintegration only into singly charged fragments are presented. (author) 21 refs, 15 figs, 1 tab

  5. Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet.

    Science.gov (United States)

    Hayashi, Takahiro; Nozaki, Yuriko; Nishizuka, Makoto; Ikawa, Masahito; Osada, Shigehiro; Imagawa, Masayoshi

    2011-01-01

    To clarify the molecular mechanism of adipocyte differentiation, we previously isolated a novel gene, factor for adipocyte differentiation (fad) 158, whose expression was induced during the earliest stages of adipogenesis, and its product was localized to the endoplasmic reticulum. We found that the knockdown of fad158 expression prevented the differentiation of 3T3-L1 cells into adipocytes. In addition, over-expression of fad158 promoted the differentiation of NIH-3T3 cells, which do not usually differentiate into adipocytes. Although these findings strongly suggest that fad158 has a crucial role in regulating adipocyte differentiation, the physiological role of the gene is still unclear. In this study, we generated mice in which fad158 expression was deleted. The fad158-deficient mice did not show remarkable changes in body weight or the weight of white adipose tissue on a chow diet, but had significantly lower body weights and fat mass than wild-type mice when fed a high-fat diet. Furthermore, although the disruption of fad158 did not influence insulin sensitivity on the chow diet, it improved insulin resistance induced by the high-fat diet. These results indicate that fad158 is a key factor in the development of obesity and insulin resistance caused by a high-fat diet.

  6. The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

    NARCIS (Netherlands)

    Klebe, Stephan; Golmard, Jean-Louis; Nalls, Michael A.; Saad, Mohamad; Singleton, Andrew B.; Bras, Jose M.; Hardy, John; Simon-Sanchez, Javier; Heutink, Peter; Kuhlenbäumer, Gregor; Charfi, Rim; Klein, Christine; Hagenah, Johann; Gasser, Thomas; Wurster, Isabel; Lesage, Suzanne; Lorenz, Delia; Deuschl, Günther; Durif, Franck; Pollak, Pierre; Damier, Philippe; Tison, François; Durr, Alexandra; Amouyel, Philippe; Lambert, Jean-Charles; Tzourio, Christophe; Maubaret, Cécilia; Charbonnier-Beaupel, Fanny; Tahiri, Khadija; Vidailhet, Marie; Martinez, Maria; Brice, Alexis; Corvol, Jean-Christophe; Agid, Y.; Anheim, M.; Bonnet, A.-M.; Borg, M.; Brice, A.; Broussolle, E.; Corvol, J.-C.; Damier, Ph; Destée, A.; Durr, A.; Durif, F.; Klebe, S.; Lohmann, E.; Martinez, M.; Penet, C.; Pollak, P.; Krack, P.; Rascol, O.; Tison, F.; Tranchant, C.; Vérin, M.; Viallet, F.; Plagnol, Vincent; Hernandez, Dena G.; Sharma, Manu; Sheerin, Una-Marie; Simón-Sánchez, Javier; Schulte, Claudia; Sveinbjörnsdóttir, Sigurlaug; Arepalli, Sampath; Band, Gavin; Barker, Roger A.; Bellinguez, Céline; Ben-Shlomo, Yoav; Berendse, Henk W.; Berg, Daniela; Bhatia, Kailash; de Bie, Rob Ma; Biffi, Alessandro; Bloem, Bas; Bochdanovits, Zoltan; Bonin, Michael; Brockmann, Kathrin; Brooks, Janet; Burn, David J.; Charlesworth, Gavin; Chen, Honglei; Chinnery, Patrick F.; Chong, Sean; Clarke, Carl E.; Cookson, Mark R.; Cooper, J. Mark; Corvol, Jean Christophe; Counsell, Carl; Dartigues, Jean-François; Deloukas, Panos; Dexter, David T.; van Dijk, Karin D.; Dillman, Allissa; Durif, Frank; Edkins, Sarah; Evans, Jonathan R.; Foltynie, Thomas; Freeman, Colin; Gao, Jianjun; Gardner, Michelle; Gibbs, Raphael; Goate, Alison; Gray, Emma; Guerreiro, Rita; Gústafsson, Omar; Harris, Clare; Hellenthal, Garrett; van Hilten, Jacobus J.; Hofman, Albert; Hollenbeck, Albert; Holton, Janice; Hu, Michele; Huang, Xuemei; Huber, Heiko; Hudson, Gavin; Hunt, Sarah E.; Huttenlocher, Johanna; Illig, Thomas; Jónsson, Pálmi V.; Langford, Cordelia; Lees, Andrew; Lichtner, Peter; Limousin, Patricia; Lopez, Grisel; McNeill, Alisdair; Moorby, Catriona; Morris, Huw; Morrison, Karen E.; Mudanohwo, Ese; O'Sullivan, Sean S.; Pearson, Justin; Pearson, Richard; Perlmutter, Joel S.; Pétursson, Hjörvar; Pirinen, Matti; Post, Bart; Potter, Simon; Ravina, Bernard; Revesz, Tamas; Riess, Olaf; Rivadeneira, Fernando; Rizzu, Patrizia; Ryten, Mina; Sawcer, Stephen; Schapira, Anthony; Scheffer, Hans; Shaw, Karen; Shoulson, Ira; Sidransky, Ellen; de Silva, Rohan; Smith, Colin; Spencer, Chris Ca; Stefánsson, Hreinn; Steinberg, Stacy; Stockton, Joanna D.; Strange, Amy; Su, Zhan; Talbot, Kevin; Tanner, Carlie M.; Tashakkori-Ghanbaria, Avazeh; Trabzuni, Daniah; Traynor, Bryan J.; Uitterlinden, G.; Vandrovcova, Jana; Velseboer, Daan; Vukcevic, Damjan; Walker, Robert; van de Warrenburg, Bart; Weale, Michael E.; Wickremaratchi, Mirdhu; Williams, Nigel; Williams-Gray, Caroline H.; Winder-Rhodes, Sophie; Donnelly, Peter; Wood, Nicholas W.

    2013-01-01

    The catechol-O-methyltranferase (COMT) is one of the main enzymes that metabolise dopamine in the brain. The Val158Met polymorphism in the COMT gene (rs4680) causes a trimodal distribution of high (Val/Val), intermediate (Val/Met) and low (Met/Met) enzyme activity. We tested whether the Val158Met

  7. TRITEX. A ferritic steel loop with Pb-15.8Li. Facility and operation

    Energy Technology Data Exchange (ETDEWEB)

    Feuerstein, H.; Horn, S.; Kieser, G.

    1999-05-01

    TRITEX was a pumped loop with Pb-15.8Li, fabricated from steel 1.4922. In contact with the molten eutectic were also molybdenum, vanadium and armco-iron. The loop was originally designed to investigate tritium extraction using solid getter metals. Over the years the goal changed to the study of metals, corrosion products and purification of the eutectic mixture. Therefore many modifications were done. The first part of this report describes TRITEX. All parts were enclosed in thermoboxes for a homogeneous temperature. One test section was in an argon glove box and could be opened during operation. Other special equipment`s were: permeation membranes and liquid-metal-covergas-interfaces to study the transport of H{sub 2}, D{sub 2} and {sup 3}H, different purification devices, a quartz observation window to see the liquid metal surface, 4 different kinds of flow measurements, level indicators, freeze valves. The second part describes loop operation. Between 1989 and 1996, the eutectic mixture was in circulation for 13 003 hours in seven experimental phases. Temperatures in the main loop were mostly between 400 and 480 C, flow rates up to 2.8 l/min. The cold trap by-pass was operated between 240 and 270 C. Depending on goals for an experiment, parts of the loop were modified. After phase V and VII TRITEX was dismantled and all parts analyzed for impurities and deposits. A third part shows photos of the facility and components. (orig.) [Deutsch] TRITEX war ein Kreislauf mit Pb15.8Li aus ferritischem Stahl. Molybdaen, Vanadium und reines Eisen waren ebenfalls in Kontakt mit der eutektischen Mischung. Der Kreislauf war urspruenglich fuer die Extraktion von Tritium mit festen Getterstoffen ausgelegt. Im Laufe der Zeit verschoben sich die Aufgaben mehr zum Verhalten von Metallen und zur Abtrennung von Verunreinigungen und Korrosionsprodukten. Die Anlage wurde entsprechend den jeweiligen Versuchszielen modifiziert. Im ersten Berichtsteil wird die Anlage beschrieben. Zur

  8. THE LOCAL [C ii] 158 μ m EMISSION LINE LUMINOSITY FUNCTION

    Energy Technology Data Exchange (ETDEWEB)

    Hemmati, Shoubaneh; Yan, Lin; Capak, Peter; Faisst, Andreas; Masters, Daniel [Infrared Processing and Analysis Center, Department of Astronomy, California Institute of Technology, 1200 E. California Blvd., Pasadena CA 91125 (United States); Diaz-Santos, Tanio [Nucleo de Astronomia de la Facultad de Ingenieria, Universidad Diego Portales, Av. Ejercito Libertador 441, Santiago (Chile); Armus, Lee, E-mail: shemmati@ipac.caltech.edu [Spitzer Science Center, Department of Astronomy, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125 (United States)

    2017-01-01

    We present, for the first time, the local [C ii] 158 μ m emission line luminosity function measured using a sample of more than 500 galaxies from the Revised Bright Galaxy Sample. [C ii] luminosities are measured from the Herschel PACS observations of the Luminous Infrared Galaxies (LIRGs) in the Great Observatories All-sky LIRG Survey and estimated for the rest of the sample based on the far-infrared (far-IR) luminosity and color. The sample covers 91.3% of the sky and is complete at S{sub 60μm} > 5.24 Jy. We calculate the completeness as a function of [C ii] line luminosity and distance, based on the far-IR color and flux densities. The [C ii] luminosity function is constrained in the range ∼10{sup 7–9} L{sub ⊙} from both the 1/ V{sub max} and a maximum likelihood methods. The shape of our derived [C ii] emission line luminosity function agrees well with the IR luminosity function. For the CO(1-0) and [C ii] luminosity functions to agree, we propose a varying ratio of [C ii]/CO(1-0) as a function of CO luminosity, with larger ratios for fainter CO luminosities. Limited [C ii] high-redshift observations as well as estimates based on the IR and UV luminosity functions are suggestive of an evolution in the [C ii] luminosity function similar to the evolution trend of the cosmic star formation rate density. Deep surveys using the Atacama Large Millimeter Array with full capability will be able to confirm this prediction.

  9. Urgent thoracotomy for penetrating chest trauma: analysis of 158 patients of a single center.

    Science.gov (United States)

    Onat, Serdar; Ulku, Refik; Avci, Alper; Ates, Gungor; Ozcelik, Cemal

    2011-09-01

    Penetrating injuries to the chest present a frequent and challenging problem, but the majority of these injuries can be managed non-\\operatively. The aim of this study was to describe the incidence of penetrating chest trauma and the ultimate techniques used for operative management, as well as the diagnosis, complications, morbidity and mortality. A retrospective 9-year review of patients who underwent an operative procedure following penetrating chest trauma was performed. The mechanism of injury, gender, age, physiological and outcome parameters, including injury severity score (ISS), chest abbreviated injury scale (AIS) score, lung injury scale score, concomitant injuries, time from admission to operating room, transfusion requirement, indications for thoracotomy, intra-operative findings, operative procedures, length of hospital stay (LOS) and rate of mortality were recorded. A total of 1123 patients who were admitted with penetrating thoracic trauma were investigated. Of these, 158 patients (93 stabbings, 65 gunshots) underwent a thoracotomy within 24 h after the penetrating trauma. There were 146 (92.4%) male and 12 (7.6%) female patients, and their mean age was 25.72 9.33 (range, 15–54) years. The mean LOS was 10.65 8.30 (range, 5–65) days. Patients admitted after a gunshot had a significantly longer LOS than those admitted with a stab wound (gunshot, 13.53 9.92 days; stab wound, 8.76 6.42 days, p chest AIS score (p chest requiring a thoracotomy are uncommon, and lung-sparing techniques have become the most frequently used procedures for lung injuries. The presence of associated abdominal injuries increased the mortality five-fold. Factors that affected mortality were ISS, chest AIS score, SBP, ongoing chest output, blood transfusion volume, diaphragmatic injury and associated abdominal injury.

  10. The role of the COMT val158met polymorphism in mediating aversive learning in visual cortex.

    Science.gov (United States)

    Gruss, L Forest; Langaee, Taimour; Keil, Andreas

    2016-01-15

    The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Previous research has identified systematic inter-individual differences in cognitive and behavioral phenotypes related to this polymorphism, often attributed to the fact that extracellular dopamine in the prefrontal cortex is strongly affected by the COMT enzyme. The neurophysiological mechanisms mediating these inter-individual differences in specific brain systems and task contexts remain to be established however. In the current study, we examined the extent to which physio-mechanistic differences by COMT genotype affect somato-visceral and visual cortical responses to learned threat cues. Classical aversive differential conditioning was implemented using rapidly phase-reversing grating stimuli, previously shown to engage retinotopic visual cortex. Differential response patterns in sensory and autonomic systems were elicited by pairing one grating (CS+, conditioned stimulus), but not the other (CS-), with a noxious stimulus. Dense-array electroencephalography and somato-visceral measures of defensive reactivity were recorded in addition to self-report data. Individuals of the Val/Val genotype, compared to Met allele carriers, reliably showed greater initial enhancement in their visuocortical response to the CS+, accompanied by stronger defensive engagement, indexed by heart rate acceleration and startle potentiation. The finding that COMT polymorphism status affects threat cue reactivity at the visuocortical level is consistent with the notion that sensory processing of threat is facilitated by strong re-entrant bias signals from anterior areas, including the prefrontal cortex. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Production of neutral pions Pb+Au collisions at 158 AGeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Soualah, Rachik

    2009-06-24

    The direct photons are a particularly useful probe to search for an evidence of the Quark-Gluon Plasma formation in ultra-relativistic heavy-ion collisions. Direct photons can be extracted experimentally by measuring the large background from {pi}{sup 0} and {eta} meson decays. This thesis work represents the production of the neutral pion mesons measured with the CERES/NA45 experiment at the top SPS energy in 158 AGeV/c Pb-Au collisions. The {pi}{sup 0} {yields} {gamma}{gamma} (98.8%) is the decay channel used in the reconstruction scheme. The {pi}{sup 0} measurement is based on the data taken in the year 2000. The CERES experiment can measure the photons that convert shortly before the TPC by measuring the e{sup +}e{sup -} pairs in the TPC. The RICH2 mirror is the main converter used for this analysis. The presented analysis method describes in more details the selection of the e{sup +} and e{sup -} tracks using only the TPC information to reconstruct the converted photon. A Secondary vertex technique was developed and used to select the photons converted in the RICH2 mirror area. The extraction of the {pi}{sup 0} needs a careful study of the combinatorial background determined using the mixed event technique. The obtained invariant mass distribution of the two photons defined well the {pi}{sup 0} peak. The neutral pion transverse spectra compared to phenomenological models and other experiments validate our analysis method. (orig.)

  12. Are Mechanistic and Statistical QSAR Approaches Really Different? MLR Studies on 158 Cycloalkyl-Pyranones.

    Science.gov (United States)

    Bhhatarai, Barun; Garg, Rajni; Gramatica, Paola

    2010-07-12

    Two parallel approaches for quantitative structure-activity relationships (QSAR) are predominant in literature, one guided by mechanistic methods (including read-across) and another by the use of statistical methods. To bridge the gap between these two approaches and to verify their main differences, a comparative study of mechanistically relevant and statistically relevant QSAR models, developed on a case study of 158 cycloalkyl-pyranones, biologically active on inhibition (Ki ) of HIV protease, was performed. Firstly, Multiple Linear Regression (MLR) based models were developed starting from a limited amount of molecular descriptors which were widely proven to have mechanistic interpretation. Then robust and predictive MLR models were developed on the same set using two different statistical approaches unbiased of input descriptors. Development of models based on Statistical I method was guided by stepwise addition of descriptors while Genetic Algorithm based selection of descriptors was used for the Statistical II. Internal validation, the standard error of the estimate, and Fisher's significance test were performed for both the statistical models. In addition, external validation was performed for Statistical II model, and Applicability Domain was verified as normally practiced in this approach. The relationships between the activity and the important descriptors selected in all the models were analyzed and compared. It is concluded that, despite the different type and number of input descriptors, and the applied descriptor selection tools or the algorithms used for developing the final model, the mechanistical and statistical approach are comparable to each other in terms of quality and also for mechanistic interpretability of modelling descriptors. Agreement can be observed between these two approaches and the better result could be a consensus prediction from both the models. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Sodium terbium(III polyphosphate

    Directory of Open Access Journals (Sweden)

    Abdelghani Oudahmane

    2010-04-01

    Full Text Available Single crystals of the title compound, NaTb(PO34, were obtained by solid-state reaction. This compound belongs to type II of long-chain polyphosphates with the general formula AIBIII(PO34. It is isotypic with the NaNd(PO34 and NaEr(PO34 homologues. The crystal structure is built up of infinite crenelated chains of corner-sharing PO4 tetrahedra with a repeating unit of four tetrahedra. These chains, extending parallel to [100], are linked by isolated TbO8 square antiprisms, forming a three-dimensional framework. The Na+ ions are located in channels running along [010] and are surrounded by six oxygen atoms in a distorted octahedral environment within a cut-off distance <2.9 Å.

  14. Proline affects brain function in 22q11DS children with the low activity COMT 158 allele.

    Science.gov (United States)

    Vorstman, Jacob A S; Turetsky, Bruce I; Sijmens-Morcus, Monique E J; de Sain, Monique G; Dorland, Bert; Sprong, Mirjam; Rappaport, Eric F; Beemer, Frits A; Emanuel, Beverly S; Kahn, René S; van Engeland, Herman; Kemner, Chantal

    2009-02-01

    The association between the 22q11.2 deletion syndrome (22q11DS) and psychiatric disorders, particularly psychosis, suggests a causal relationship between 22q11DS genes and abnormal brain function. The genes catechol-O-methyl-transferase (COMT) and proline dehydrogenase both reside within the commonly deleted region of 22q11.2. COMT activity and proline levels may therefore be altered in 22q11DS individuals. Associations of both COMT(158) genotype and elevated serum proline levels with abnormal brain function have been reported. Fifty-six 22q11DS children and 75 healthy controls were assessed on physiological measures of brain function, including prepulse inhibition (PPI) of startle, P50 auditory sensory gating and smooth pursuit eye movements (SPEM). COMT(158) genotype and plasma proline levels were determined in the 22q11DS children. We hypothesized an interaction between the COMT(158) genotype and proline, predicting the strongest negative effect of high proline on brain function to occur in 22q11DS children who are carriers of the COMT(met) allele. Of the three physiological measures, only SPEM and PPI were abnormal in the patient sample. With regard to the SPEM performance, there was a significant interaction between the COMT(158) genotype and proline level with significantly decreased SPEM performance in children with high plasma proline levels and the low activity COMT(met) allele. A similar interaction effect was not observed with regard to PPI. These findings are consistent with a model in which elevated proline negatively affects brain function by an increase in dopamine in the prefrontal cortex. 22q11DS patients with low dopamine catabolic capacity are therefore especially vulnerable to this functional disruption.

  15. Impact of Catechol-O-Methyltransferase Val 158Met (rs4680) Polymorphism on Breast Cancer Susceptibility in Asian Population

    Science.gov (United States)

    Rai, Vandana; Yadav, Upendra; Kumar, Pradeep

    2017-05-01

    Background: Catechol-O-methyltransferase (COMT) is an important estrogen-metabolizing enzyme. Numerous case-control studies have evaluated the role COMT Val 158Met (rs4680;472G->A) polymorphism in the risk of breast cancer and provided inconclusive results, hence present meta-analysis was designed to get a more reliable assessment in Asian population. Methods: A total of 26 articles were identified through a search of four electronic databases- PubMed, Google Scholar, Science Direct and Springer link, up to March, 2016. Pooled odds ratios (ORs) with 95% con¬fidence intervals (CIs) were used as association measure to find out relationship between COMT Val158Metpolymorphism and the risk of breast cancer. We also assessed between study heterogeneity and publication bias. All statistical analyses were done by Open Meta-Analyst. Results: Twenty six case-control studies involving 5,971 breast cancer patients and 7,253 controls were included in the present meta-analysis. The results showed that the COMT Val158Met polymorphism was significantly associated with breast cancer risk except heterozygote model(allele contrast odds ratio (ORAvsG)= 1.13, 95%CI=1.02-1.24,p=0.01; heterozygote/co-dominant ORGAvsGG= 1.03, 95%CI=0.96-1.11,p=0.34; homozygote ORAAvsGG= 1.38, 95%CI= 1.08-1.76,p=0.009; dominant model ORAA+GAvsGG= 1.08, 95%CI=1.01-1.16,p=0.02; and recessive model ORAAvsGA+GG= 1.35, 95%CI=1.07-1.71,p=0.01). In addition, we also performed subgroup analysis based on source of controls and menopausal state of patients. Conclusions: In conclusion, the COMT Val158Met polymorphism was related to increased breast cancer susceptibility in the Asian population. Creative Commons Attribution License

  16. Transverse mass distributions of neutral pions from 208Pb-induced reactions at 158 A GeV

    NARCIS (Netherlands)

    Aggarwal, M.M.; Agnihotri, A.; Ahammed, Z.A.; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Barlag, C.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bock, R.; Bohne, E.-M.; Böröcz, Z.K.; Bucher, D.; Buijs, A.; Büsching, H.; Carlén, L.; Chalyshev, V.; Chattopadhyay, S.; Cherbatchev, R.; Chujo, T.; Claussen, A.; Das, A.C.; Decowski, M.P.; Delagrange, H.; Djordjadze, V.; Donni, P.; Doubovik, I.; Dubey, A.K.; Dutt, S.; Dutta Majumdar, M.R.; El Chenawi, K.; Eliseev, S.; Enosawa, K.; Foka, P.; Fokin, S.; Ganti, M.S.; Garpmann, S.; Gavrishchuk, O.; Geurts, F.; Ghosh, T.K.; Glasow, R.; Gupta, S.K.; Guskov, B.; Gustafsson, H.-A.; Gutbrod, H.H.; Higuchi, R.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Kampert, K.-H.; Karadjev, K.; Karpio, K.; Kato, S.; Kees, S.; Klein-Bösing, C.; Knoche, S.; Kolb, B.; Kosarev, I.; Koutcheryaev, I.; Krümpel, T.; Kugler, A.; Kulinich, P.; Kurata, M.; Kurita, K.; Kuzmin, N.; Langbein, I.; Bevedev, A.; Lee, Y.Y.; Löhner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Mgebrichvili, G.; Miake, Y.; Mir, Md.F.; Mishra, G.C.; Mitamoto, Y.; Mohanti, B.; Mora, M.-J.; Morrison, D.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Neumaier, S.

    Results on transverse mass spectra of neutral pious measured at central rapidity are presented for impact parameter selected 158-A GeV Pb + Pb-1 and Pb + Nb collisions. The distributions cover the range 0.5 GeV/c(2) less than or equal to MT - Mo less than or equal to 4 GeV/c(2). The change of the

  17. Determination of the number of wounded nucleons in Pb+Pb collisions at 158 A GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Antinori, F.; Badala, A.; Bakke, H.; Barbera, R.; Beker, H.; Beusch, W.; Bloodworth, I.J.; Botje, M.; Caliandro, R.; Campbell, M.; Cantatore, E.; Carena, W.; Carrer, N.; Haas, A.P. de; Di Bari, D.; Di Liberto, S.; Divia, R.; Elia, D.; Evans, D.; Fanebust, K.; Fedorisin, J.; Feofilov, G.A.; Fini, R.A.; Ftacnik, J.; Ghidini, B.; Grella, G.; Gulino, M.; Helstrup, H.; Holme, A.K.; Huss, D.; Jacholkowski, A.; Jones, G.T.; Jovanovic, P.; Jusko, A.; Kamermans, R.; Kinson, J.B.; Klempt, W.; Knudson, K.; Kocper, B.; Kolojvari, A.A.; Kralik, I.; Kuijer, P.; Lenti, V.; Lietava, R.; Loconsole, R.A.; Loevhoeiden, G.; Luptak, M.; Manzari, V.; Mazzoni, M.A.; Martinska, G.; Meddi, F.; Michalon, A.; Michalon-Mentzer, M.E.; Morando, M.; Nappi, E.; Navach, F.; Norman, P.I.; Palmeri, A.; Pappalardo, G.S.; Pastircak, B.; Pellegrini, F.; Piska, K.; Pisut, J.; Pisutova, N.; Posa, F.; Quercigh, E.; Riggi, F.; Romano, G.; Safarik, K.; Sandor, L.; Schillings, E.; Segato, G.; Sene, M.; Sene, R.; Snoeys, W.; Staroba, P.; Stolyarov, O.I.; Thompson, M.; Thorsteinsen, T.F.; Tomasicchio, G.; Torrieri, G.D.; Tsimbal, F.A.; Tulina, T.A.; Tveter, T.S.; Urban, J.; Valiev, F.F.; Brink, A. van den; Ven, P. van de; Vande Vyvre, P.; Eijndhoven, N. van; Vannucci, L.; Vascotto, A.; Baillie, O. Villalobos; Vinogradov, I.; Virgili, T.; Votruba, M.F.; Vrlakova, J.; Zavada, P

    1999-12-27

    The charged particle multiplicity distributions measured with the WA97 and the NA57 multiplicity detectors in Pb+Pb collisions at 158 A GeV/c have been analyzed in the framework of the Wounded Nucleon Model (WNM). We obtain a good description of the data within the centrality range of our samples. This allows us to make use of the measured multiplicities to estimate the number of wounded nucleons of the collision.

  18. Determination of the number of wounded nucleons in Pb+Pb collisions at 158 A GeV/c

    CERN Document Server

    Antinori, Federico; Bakke, H; Barbera, R; Beker, H; Beusch, Werner; Bloodworth, Ian J; Botje, M; Caliandro, R; Campbell, M; Cantatore, E; Carena, W; Carrer, N; De Haas, A P; Di Bari, D; Di Liberto, S; Divià, R; Elia, D; Evans, D; Fanebust, K; Fedorisin, J; Feofilov, G A; Fini, R A; Ftácnik, J; Ghidini, B; Grella, G; Gulino, M; Helstrup, H; Holme, A K; Huss, D; Jacholkowski, A; Jones, G T; Jovanovic, P; Jusko, A; Kamermans, R; Kinson, J B; Klempt, W; Knudson, K; Kolojvari, A A; Králik, I; Kuijer, P; Lenti, V; Lietava, R; Loconsole, R A; Løvhøiden, G; Lupták, M; Manzari, V; Mazzoni, M A; Martinská, G; Meddi, F; Michalon, A; Michalon-Mentzer, M E; Morando, M; Nappi, E; Navach, F; Norman, P I; Palmeri, A; Pappalardo, G S; Pastircák, B; Pellegrini, F; Pisút, J; Pisútová, N; Posa, F; Quercigh, Emanuele; Riggi, F; Röhrich, D; Romano, G; Safarík, K; Sándor, L; Schillings, E; Segato, G F; Snoeys, W; Staroba, P; Stolyarov, O I; Thompson, M; Thorsteinsen, T F; Tomasicchio, G; Torrieri, G D; Tsimbal, F A; Tulina, T A; Turrisi, R; Tveter, T S; Urbán, J; Valiev, F F; Van den Brink, A; Van de Ven, P; Van de Vyvre, P; van Eijndhoven, N; Vannucci, Luigi; Vascotto, Alessandro; Villalobos Baillie, O; Vinogradov, I; Virgili, T; Votruba, M F; Vrláková, J; Závada, P

    1999-01-01

    The charged particle multiplicity distributions measured with the WA97 and the NA57 multiplicity detectors in Pb+Pb collisions at 158 A GeV/c have been analyzed in the framework of the Wounded Nucleon Model (WNM). We obtain a good description of the data within the centrality range of our samples. This allows us to make use of the measured multiplicities to estimate the number of wounded nucleons of the collision.

  19. Interferometry of direct photons in central $^{208}$Pb+$^{208}$Pb collisions at 158A GeV

    CERN Document Server

    Aggarwal, M M; Angelis, A L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bucher, D; Büsching, H; Carlén, L; Chattopadhyay, S; Decowski, M P; Delagrange, H; Dönni, P; Majumdar, M R D; Chenawi, K E; Dubey, A K; Enosawa, K; Fokin, S; Frolov, V; Ganti, M S; Garpman, S; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Karadzhev, K; Karpio, K; Kolb, B W; Kosarev, I G; Kucheryaev, I; Kugler, A; Kulinich, P; Kurata, M; Lebedev, A; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V; Martin, M; Martínez, G; Maksimov, A; Miake, Y; Mishra, G C; Mohanty, B G; Mora, M J; Morrison, Douglas Robert Ogston; Moukhanova, T; Mukhopadhyay, D S; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Nyanin, A; Nikitin, V; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, V P; Nystrand, J; Oskarsson, A; Otterlund, I; Peitzmann, T; Peressounko, D Yu; Petracek, V; Phatak, S C; Pinganaud, W; Plasil, F; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Sood, G; Srensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A A; Tykarski, L; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Young, G R

    2004-01-01

    Two-particle correlations of direct photons were measured in central /sup 208208/Pb+Pb collisions at 158A GeV. The invariant interferometric radii were extracted for 100

  20. $\\Delta^{++}$ production in 158 A GeV $^{208}Pb+^{208}Pb$ interactions at the CERN SPS

    CERN Document Server

    Aggarwal, M M; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Baldin, A; Barabash, L; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bock, R; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Delagrange, H; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S K; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Frolov, V; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Martínez, G; Maksimov, A; Mehdiyev, R; Mgebrishvili, G; Miake, Y; Mikhalev, D; Mir, M F; Mishra, G C; Miyamoto, Y; Mohanty, B; Morrison, D; Mukhopadhyay, D S; Myalkovskii, V; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Parfenov, A; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Plasil, F; Pinganaud, W; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Tykarski, L; Urbahn, J; Van der Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    2000-01-01

    The Delta /sup ++/-resonance production in central 158 A GeV /sup 208 /Pb+/sup 208/Pb collisions at the CERN SPS has been studied. The Delta /sup ++/ production was estimated from the invariant mass spectrum of p pi /sup +/-pairs by subtracting a mixed event background. The measured Delta /sup ++/ abundance is compared with the results from other experiments at lower energies, and with a model calculation assuming thermal and chemical equilibrium. (19 refs).

  1. VNTR-DAT1 and COMTVal158Met genotypes modulate mental flexibility and adaptive behavior skills in Down syndrome

    Directory of Open Access Journals (Sweden)

    Laura Del Hoyo

    2016-10-01

    Full Text Available Down syndrome (DS is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC deficits. DS also present a high risk for early onset of Alzheimer Disease (AD-like dementia. The dopamine (DA system plays a neuromodulatory role in the activity of the PFC. Several studies have implicated trait differences in DA signaling on executive functioning based on genetic polymorphisms in the genes encoding for the catechol-O-methyltransferase (COMTVal158Met and the dopamine transporter (VNTR-DAT1. Since it is known that the phenotypic consequences of genetic variants are modulated by the genetic background in which they occur, we here explore whether these polymorphisms variants interact with the trisomic genetic background to influence gene expression, and how this in turn mediates DS phenotype variability regarding PFC cognition. We genotyped 69 young adults of both genders with DS, and found that VNTR-DAT1 was in Hardy-Weinberg equilibrium but COMTVal158Met had a reduced frequency of Met allele homozygotes. In our population, genotypes conferring higher DA availability, such as Met allele carriers and VNTR-DAT1 10-repeat allele homozygotes, resulted in improved performance in executive function tasks that require mental flexibility. Met allele carriers showed worse adaptive social skills and self-direction, and increased scores in the social subscale of the Dementia Questionnaire for People with Intellectual Disabilities than Val allele homozygotes. The VNTR-DAT1 was not involved in adaptive behavior or early dementia symptoms. Our results suggest that genetic variants of COMTVal158Met and VNTR-DAT1 may contribute to PFC-dependent cognition, while only COMTVal158Met is involved in behavioral phenotypes of DS, similar to euploid population.

  2. SLAC's Polarized Electron Source LaserSystem and Minimization of Helicity Correlations for the E-158 Parity Violation Experiment

    CERN Document Server

    Humensky, T

    2002-01-01

    SLAC E-158 is an experiment designed to make the first measurement of parity violation in Moeller scattering. E-158 will measure the right-left cross-section asymmetry, A sub L sub R sup M sup o sup e sup l sup l sup e sup r , in the elastic scattering of a 45-GeV polarized electron beam off unpolarized electrons in a liquid hydrogen target. E-158 plans to measure the expected Standard Model asymmetry of approx 10 sup - sup 7 to an accuracy of better than 10 sup - sup 8. To make this measurement, the polarized electron source requires for operation an intense circularly polarized laser beam and the ability to quickly switch between right- and left-helicity polarization states with minimal right-left helicity-correlated asymmetries in the resulting beam parameters (intensity, position, angle, spot size, and energy), sup b sup e sup a sup m A sub L sub R 's. This laser beam is produced by a unique SLAC-designed flashlamp-pumped Ti:Sapphire laser and is propagated through a carefully designed set of polarization...

  3. COMT (Val158Met and BDNF (Val66Met Genes Polymorphism in Schizophrenia: A Case-Control Report

    Directory of Open Access Journals (Sweden)

    ramin saravani

    2017-10-01

    Full Text Available Objective: The effects of human brain-derived neurotropic factor (BDNF Val66Met (G>A and the human Catechol-O-methylTransferase (COMT Val158Met (G>A polymorphisms on Schizophrenia (SCZ risk were evaluated.Methods: This case control study included 92 SCZ patients and 92 healthy controls (HCs. Genotyping of both variants were conducted using Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR.Results: The findings showed that BDNF Val66Met (G>A variant increased the risk of SCZ (OR=2.008 95%CI=1.008-4.00, P=0.047, GA vs. GG, OR=3.876 95%CI=1.001-14.925, P=0.049. AA vs. GG, OR=2.272. 95%CI=1.204-4.347, P=0.011, GA+AA vs. GG, OR=2.22 95%CI=1.29-3.82. P=0.005, A vs. G. COMT Val158Met (G>A polymorphism was not associated with the risk/protective of SCZ.Conclusion: The results proposed that BDNF Val66Met (G>A polymorphism may increase the risk of SCZ development and did not support an association between COMT Val158Met (G>A variant and risk/protective of SCZ. Further studies and different ethnicities are recommended to confirm the findings.

  4. The modulatory influence of the functional COMT Val158Met polymorphism on lexical decisions and semantic priming

    Directory of Open Access Journals (Sweden)

    Martin Reuter

    2009-08-01

    Full Text Available The role of the prefrontal Cortex (PFC in higher cognitive functions - including working memory, conflict resolution, set shifting and semantic processing - has been demonstrated unequivocally. Despite the great heterogeneity among tasks measuring these phenotypes, due in part to the different cognitive sub-processes implied and the specificity of the stimulus material used, there is agreement that all of these tasks recruit an executive control system located in the PFC. On a biochemical level it is known that the dopaminergic system plays an important role in executive control functions. Evidence comes from molecular genetics relating the functional COMT Val158Met polymorphism to working memory and set shifting. In order determine whether this pattern of findings generalises to linguistic and semantic processing, we investigated the effects of the COMT Val158Met polymorphism in lexical decision making using masked and unmasked versions of the semantic priming paradigm on N=104 healthy subjects. Although we observed strong priming effects in all conditions (masked priming, unmasked priming with short/long stimulus asynchronies (SOAs, direct and indirect priming, COMT was not significantly related to masked priming, suggesting no reliable influence on semantic processing. However, COMT Val158Met was strongly associated with lexical decision latencies in all priming conditions if considered separately, explaining between 9 to 14.5 % of the variance. Therefore, the findings indicate that COMT mainly influences more general executive control functions in the PFC supporting the speed of lexical decisions.

  5. Dielectron production in heavy ion collisions at 158 GeV/c per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Busch, Oliver

    2007-12-03

    In this thesis we study dilepton production in Pb-Au collisions at 158 GeV/c per nucleon measured with the Cherenkov Ring Electron Spectrometer (CERES) at the Super Proton Synchrotron (SPS) at CERN. The data taken in the year 2000 represent the first CERES runs with the fully operational Time Projection Chamber (TPC). The upgrade of the spectrometer with this powerful tracking device allows to realize a new approach for particle identification with the Ring Imaging Cherenkov (RICH) detector. We present the development and optimization of track-based ring reconstruction methods which allow to identify both electrons and pions at momenta above the Cherenkov threshold. To compare the performance of different methods, the reconstruction is applied to the CERES data. This allows to determine experimentally, for the first time, the CERES RICH efficiency and background rejection power. The new particle identification is used for low-mass dielectron reconstruction. Significant improvements in the simulation of the detector allow to evaluate the electron pair reconstruction efficiency with high accuracy and to study the origin of electron pair combinatorial background. The results motivate an extension of the TPC tracking, to improve the reconstruction efficiency for low-momentum tracks, and allow better identification of electron background. Our results corroborate the previous CERES findings of an enhancement of electron pairs over the hadronic cocktail in the invariant mass region m{sub inv} >or similar 0.2 GeV/c{sup 2}. Comparison to previous analyses of the same data shows good consistency and supports our estimate of the systematic uncertainties of the electron analysis. Our results supply evidence for a modification of the spectral function of the {rho} meson in the hot and dense medium and strongly support baryon-induced interactions at the origin of the effect. Furthermore, we present in this work the first direct measurements of transition radiation (TR) spectra

  6. Association between the COMT Val158Met Genotype and Alzheimer's Disease in the Han Chinese Population

    Directory of Open Access Journals (Sweden)

    Yong Ji

    2014-01-01

    Full Text Available Background: Alzheimer's disease (AD is the leading cause of dementia worldwide and is associated with individual, familial and social burdens. Catechol-O-methyltransferase (COMT may have a prominent role in AD pathophysiology by affecting the metabolism of catecholamine neurotransmitters and estrogen. Although the COMT rs4680 gene polymorphism has been investigated as a susceptibility factor for AD, the results are inconsistent. The aim of this study was to examine the influence of the COMT rs4680 gene polymorphism as a risk factor for AD in the Han Chinese population and its synergistic effect with the apolipoprotein E (APOE gene. Methods: A total of 137 AD patients and 194 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups. All subjects were analyzed for the COMT rs4680 polymorphism and APOE genotype. Results: No significant differences were observed between AD and control subjects regarding the COMT genotype frequencies of Val/Val, Val/Met and Met/Met, but Met alleles were higher in AD than in control subjects (35.4 and 28.1%, p = 0.045. A minor synergistic effect between the genotypes GG and APOE ε4 was observed in AD patients (OR: 5.707, 95% CI: 2.505-13.002, p APOE ε4 (11.972, 95% CI: 5.534-25.902, p COMT Met allele was an independent risk factor for AD without APOE ε4 allele carriers (OR: 1.806, 95% CI: 1.160-2.810, p = 0.009, especially in men (OR: 4.904, 95% CI: 2.381-10.099, p Conclusion: The COMT (Val158Met polymorphism is not an independent risk factor for AD but shows a synergistic effect between the genotypes GG and APOE ε4 that proves greater in women with AD. The COMT Met allele represents a risk factor in AD without APOE ε4 allele carriers, which is notable in men with AD.

  7. The impact of the Val158Met COMT polymorphism on context processing in patients on the schizophrenia spectrum and their relatives

    Directory of Open Access Journals (Sweden)

    Pilar López-García

    2015-12-01

    Conclusions: Deficits in context processing in schizophrenic patients and their families are influenced by the Val158Met COMT functional polymorphism, likely as a consequence of reduced dopamine availability in the PFC.

  8. Hyperon production in 158 and 40 A GeV/c Pb-Pb and p-Be collisions from the NA57 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Antinori, F.; Bacon, P.A.; Badala, A.; Barbera, R.; Belogianni, A.; Bhasin, A.; Bloodworth, I.J.; Bombara, M.; Bruno, G.E.; Bull, S.A.; Caliandro, R.; Campbell, M.; Carena, W.; Carrer, N.; Clarke, R.F.; Dainese, A.; Haas, A.P. de; Rijke, P.C. de; Di Bari, D.; Di Liberto, S.; Divia, R.; Elia, D.; Evans, D.; Fanebust, K.; Feofilov, G.A.; Fini, R.A.; Ganoti, P.; Ghidini, B.; Grella, G.; Helstrup, H.; Holme, A.K.; Jacholkowski, A.; Jones, G.T.; Jovanovic, P.; Jusko, A.; Kamermans, R.; Kinson, J.B.; Knudson, K.; Kolozhvari, A.A.; Kondratiev, V.; Kralik, I.; Kravcakova, A.; Kuijer, P.; Lenti, V.; Lietava, R.; Loevhoeiden, G.; Manzari, V.; Martinska, G.; Mazzoni, M.A.; Meddi, F.; Michalon, A.; Morando, M.; Nappi, E.; Navach, F.; Norman, P.I.; Palmeri, A.; Pappalardo, G.S.; Pastircak, B.; Pisut, J.; Posa, F.; Quercigh, E.; Riggi, F.; Roehrich, D.; Romano, G.; Safarik, K.; Sandor, L.; Schillings, E.; Segato, G.; Sene, M.; Sene, R.; Snoeys, W.; Soramel, F.; Spyropoulou-Stassinaki, M.; Staroba, P.; Toulina, T.A.; Turrisi, R.; Tveter, T.S.; Urban, J.; Valiev, F.; Brink, A. van den; Ven, P. van de; Vande Vyvre, P.; Eijndhoven, N. van; Hunen, J. van; Vascotto, A.; Vik, T.; Villalobos-Baillie, O.; Vinogradov, L.; Virgili, T.; Votruba, M.F.; Vrlakova, J.; Zavada, P

    2004-04-05

    The NA57 experiment at the CERN SPS has measured strange baryon and antibaryon production in Pb-Pb collisions with 158 and 40 A GeV/c beam momenta. Recent results on {lambda}, {xi} and {omega} hyperon enhancements and from the transverse mass spectra analysis for the 158 A GeV/c data sample are presented. The energy dependence of hyperon production at mid-rapidity is discussed.

  9. Protective Role of Maternal P.VAL158MET Catechol-O-methyltransferase Polymorphism against Early-Onset Preeclampsia and its Complications

    Directory of Open Access Journals (Sweden)

    Krnjeta Tijana

    2016-09-01

    Full Text Available Background: Up until now there have been contradictory data about the association between p.Val158Met catechol-O-methyltransferase (COMT polymorphism and risk of preeclampsia (PE. The goal of this study was to assess the potential correlation between p.Val158Met COMT polymorphism and risk of early-onset PE, risk of a severe form of early-onset PE, as well as risk of small-for-gestationalage (SGA complicating PE.

  10. The [CII] 158 μm line emission in high-redshift galaxies

    Science.gov (United States)

    Lagache, G.; Cousin, M.; Chatzikos, M.

    2018-02-01

    Gas is a crucial component of galaxies, providing the fuel to form stars, and it is impossible to understand the evolution of galaxies without knowing their gas properties. The [CII] fine structure transition at 158 μm is the dominant cooling line of cool interstellar gas, and is the brightest of emission lines from star forming galaxies from FIR through metre wavelengths, almost unaffected by attenuation. With the advent of ALMA and NOEMA, capable of detecting [CII]-line emission in high-redshift galaxies, there has been a growing interest in using the [CII] line as a probe of the physical conditions of the gas in galaxies, and as a star formation rate (SFR) indicator at z ≥ 4. In this paper, we have used a semi-analytical model of galaxy evolution (G.A.S.) combined with the photoionisation code CLOUDY to predict the [CII] luminosity of a large number of galaxies (25 000 at z ≃ 5) at 4 ≤ z ≤ 8. We assumed that the [CII]-line emission originates from photo-dominated regions. At such high redshift, the CMB represents a strong background and we discuss its effects on the luminosity of the [CII] line. We studied the L[CII ]-SFR and L[ CII ]-Zg relations and show that they do not strongly evolve with redshift from z = 4 and to z = 8. Galaxies with higher [CII] luminosities tend to have higher metallicities and higher SFRs but the correlations are very broad, with a scatter of about 0.5 and 0.8 dex for L[ CII ]-SFR and L[ CII ]-Zg, respectively. Our model reproduces the L[ CII ]-SFR relations observed in high-redshift star-forming galaxies, with [CII] luminosities lower than expected from local L[ CII ]-SFR relations. Accordingly, the local observed L[ CII ]-SFR relation does not apply at high-z (z ≳ 5), even when CMB effects are ignored. Our model naturally produces the [CII] deficit (i.e. the decrease of L[ CII ]/LIR with LIR), which appears to be strongly correlated with the intensity of the radiation field in our simulated galaxies. We then predict the

  11. Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss.

    Science.gov (United States)

    Goel, Namni; Banks, Siobhan; Lin, Ling; Mignot, Emmanuel; Dinges, David F

    2011-01-01

    The COMT Val158Met polymorphism modulates cortical dopaminergic catabolism, and predicts individual differences in prefrontal executive functioning in healthy adults and schizophrenic patients, and associates with EEG differences during sleep loss. We assessed whether the COMT Val158Met polymorphism was a novel marker in healthy adults of differential vulnerability to chronic partial sleep deprivation (PSD), a condition distinct from total sleep loss and one experienced by millions on a daily and persistent basis. 20 Met/Met, 64 Val/Met, and 45 Val/Val subjects participated in a protocol of two baseline 10h time in bed (TIB) nights followed by five consecutive 4 h TIB nights. Met/Met subjects showed differentially steeper declines in non-REM EEG slow-wave energy (SWE)-the putative homeostatic marker of sleep drive-during PSD, despite comparable baseline SWE declines. Val/Val subjects showed differentially smaller increases in slow-wave sleep and smaller reductions in stage 2 sleep during PSD, and had more stage 1 sleep across nights and a shorter baseline REM sleep latency. The genotypes, however, did not differ in performance across various executive function and cognitive tasks and showed comparable increases in subjective and physiological sleepiness in response to chronic sleep loss. Met/Met genotypic and Met allelic frequencies were higher in whites than African Americans. The COMT Val158Met polymorphism may be a genetic biomarker for predicting individual differences in sleep physiology-but not in cognitive and executive functioning-resulting from sleep loss in a healthy, racially-diverse adult population of men and women. Beyond healthy sleepers, our results may also provide insight for predicting sleep loss responses in patients with schizophrenia and other psychiatric disorders, since these groups repeatedly experience chronically-curtailed sleep and demonstrate COMT-related treatment responses and risk factors for symptom exacerbation. © 2011 Goel et al.

  12. Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma.

    Directory of Open Access Journals (Sweden)

    Benedikt Klauke

    Full Text Available The etiology of emotion-related disorders such as anxiety or affective disorders is considered to be complex with an interaction of biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic and noradrenergic system--partly conferred by catechol-O-methyltransferase (COMT gene variation--for the adenosinergic system as well as for early life trauma to constitute risk factors for those conditions. Applying a multi-level approach, in a sample of 95 healthy adults, we investigated effects of the functional COMT Val158Met polymorphism, caffeine as an adenosine A2A receptor antagonist (300 mg in a placebo-controlled intervention design and childhood maltreatment (CTQ as well as their interaction on the affect-modulated startle response as a neurobiologically founded defensive reflex potentially related to fear- and distress-related disorders. COMT val/val genotype significantly increased startle magnitude in response to unpleasant stimuli, while met/met homozygotes showed a blunted startle response to aversive pictures. Furthermore, significant gene-environment interaction of COMT Val158Met genotype with CTQ was discerned with more maltreatment being associated with higher startle potentiation in val/val subjects but not in met carriers. No main effect of or interaction effects with caffeine were observed. Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders.

  13. Neon and [CII] 158 μm Emission Line Profiles in Dusty Starbursts and Active Galactic Nuclei

    Science.gov (United States)

    Samsonyan, A.; Weedman, D.; Lebouteiller, V.; Barry, D.; Sargsyan, L.

    2017-07-01

    Identifying and understanding the initial formation of massive galaxies and quasars in the early universe is a fundamental goal of observational cosmology. A rapidly developing capability for tracing luminosity sources to high redshifts is the observation of the [CII] 158 μm emission line at redshifts z > 4 using ground based submillimeter interferometers, with detections now having been made to z = 7. This has long been known as the strongest far-infrared line in most sources, often carrying about 1% of the total source luminosity, and is thought to be associated with star formation because it should arise within the photodissociation region (PDR) surrounding starbursts. The sample of 382 extragalactic sources has been analysed that have mid-infrared,high resolution spectroscopy with the Spitzer Infrared Spectrograph (IRS) and also spectroscopy of the [CII] 158 μm line with the Herschel Photodetector Array Camera and Spectrometer (PACS). The emission line profiles of [NeII] 12.81μm , [NeIII] 15.55 μm , and [CII] 158 μm are studied, and intrinsic line widths are determined. All line profiles together with overlays comparing positions of PACS and IRS observations are made available in the Cornell Atlas of Spitzer IRS Sources (CASSIS). Sources are classified from AGN to starburst based on equivalent widths of the 6.2 μm polycyclic aromatic hydrocarbon feature. It is found that intrinsic line widths do not change among classification for [CII], with median widths of 207 km s-1 for AGN, 248 km s-1 for composites, and 233 km s-1 for starbursts. The [NeII] line widths also do not change with classification, but [NeIII] lines are progressively broader from starburst to AGN. A small number of objects with unusually broad lines or unusual redshift differences in any feature are identified.

  14. Catechol-O-methyltransferase Val158Met polymorphism associates with individual differences in sleep physiologic responses to chronic sleep loss.

    Directory of Open Access Journals (Sweden)

    Namni Goel

    Full Text Available BACKGROUND: The COMT Val158Met polymorphism modulates cortical dopaminergic catabolism, and predicts individual differences in prefrontal executive functioning in healthy adults and schizophrenic patients, and associates with EEG differences during sleep loss. We assessed whether the COMT Val158Met polymorphism was a novel marker in healthy adults of differential vulnerability to chronic partial sleep deprivation (PSD, a condition distinct from total sleep loss and one experienced by millions on a daily and persistent basis. METHODOLOGY/PRINCIPAL FINDINGS: 20 Met/Met, 64 Val/Met, and 45 Val/Val subjects participated in a protocol of two baseline 10h time in bed (TIB nights followed by five consecutive 4 h TIB nights. Met/Met subjects showed differentially steeper declines in non-REM EEG slow-wave energy (SWE-the putative homeostatic marker of sleep drive-during PSD, despite comparable baseline SWE declines. Val/Val subjects showed differentially smaller increases in slow-wave sleep and smaller reductions in stage 2 sleep during PSD, and had more stage 1 sleep across nights and a shorter baseline REM sleep latency. The genotypes, however, did not differ in performance across various executive function and cognitive tasks and showed comparable increases in subjective and physiological sleepiness in response to chronic sleep loss. Met/Met genotypic and Met allelic frequencies were higher in whites than African Americans. CONCLUSIONS/SIGNIFICANCE: The COMT Val158Met polymorphism may be a genetic biomarker for predicting individual differences in sleep physiology-but not in cognitive and executive functioning-resulting from sleep loss in a healthy, racially-diverse adult population of men and women. Beyond healthy sleepers, our results may also provide insight for predicting sleep loss responses in patients with schizophrenia and other psychiatric disorders, since these groups repeatedly experience chronically-curtailed sleep and demonstrate COMT

  15. COMT Val158Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase Inhibition

    Science.gov (United States)

    Farrell, Sarah M.; Tunbridge, Elizabeth M.; Braeutigam, Sven; Harrison, Paul J.

    2012-01-01

    Background Catechol-O-methyltransferase (COMT) metabolizes dopamine. The COMT Val158Met polymorphism influences its activity, and multiple neural correlates of this genotype on dopaminergic phenotypes, especially working memory, have been reported. COMT activity can also be regulated pharmacologically by COMT inhibitors. The inverted-U relationship between cortical dopamine signaling and working memory predicts that the effects of COMT inhibition will differ according to COMT genotype. Methods Thirty-four COMT Met158Met (Met-COMT) and 33 COMT Val158Val (Val-COMT) men were given a single 200-mg dose of the brain-penetrant COMT inhibitor tolcapone or placebo in a randomized, double-blind, between-subjects design. They completed the N-back task of working memory and a gambling task. Results In the placebo group, Met-COMT subjects outperformed Val-COMT subjects on the 2- back, and they were more risk averse. Tolcapone had opposite effects in the two genotype groups: it worsened N-back performance in Met-COMT subjects but enhanced it in Val-COMT subjects. Tolcapone made Met-COMT subjects less risk averse but Val-COMT subjects more so. In both tasks, tolcapone reversed the baseline genotype differences. Conclusions Depending on genotype, COMT inhibition can enhance or impair working memory and increase or decrease risky decision making. To our knowledge, the data are the clearest demonstration to date that the direction of effect of a drug can be influenced by a polymorphism in its target gene. The results support the inverted-U model of dopamine function. The findings are of translational relevance, because COMT inhibitors are used in the adjunctive treatment of Parkinson's disease and are under evaluation in schizophrenia and other disorders. PMID:22364739

  16. Affect-Modulated Startle: Interactive Influence of Catechol-O-Methyltransferase Val158Met Genotype and Childhood Trauma

    Science.gov (United States)

    Klauke, Benedikt; Winter, Bernward; Gajewska, Agnes; Zwanzger, Peter; Reif, Andreas; Herrmann, Martin J.; Dlugos, Andrea; Warrings, Bodo; Jacob, Christian; Mühlberger, Andreas; Arolt, Volker; Pauli, Paul; Deckert, Jürgen; Domschke, Katharina

    2012-01-01

    The etiology of emotion-related disorders such as anxiety or affective disorders is considered to be complex with an interaction of biological and environmental factors. Particular evidence has accumulated for alterations in the dopaminergic and noradrenergic system – partly conferred by catechol-O-methyltransferase (COMT) gene variation – for the adenosinergic system as well as for early life trauma to constitute risk factors for those conditions. Applying a multi-level approach, in a sample of 95 healthy adults, we investigated effects of the functional COMT Val158Met polymorphism, caffeine as an adenosine A2A receptor antagonist (300 mg in a placebo-controlled intervention design) and childhood maltreatment (CTQ) as well as their interaction on the affect-modulated startle response as a neurobiologically founded defensive reflex potentially related to fear- and distress-related disorders. COMT val/val genotype significantly increased startle magnitude in response to unpleasant stimuli, while met/met homozygotes showed a blunted startle response to aversive pictures. Furthermore, significant gene-environment interaction of COMT Val158Met genotype with CTQ was discerned with more maltreatment being associated with higher startle potentiation in val/val subjects but not in met carriers. No main effect of or interaction effects with caffeine were observed. Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. PMID:22745815

  17. Proline Affects Brain Function in 22q11DS Children with the Low Activity COMT158 Allele

    OpenAIRE

    Vorstman, Jacob As; Turetsky, Bruce I.; Sijmens-Morcus, Monique EJ; de Sain, Monique G; Dorland, Bert; Sprong, Mirjam; Rappaport, Eric F.; Beemer, Frits A; Emanuel, Beverly S.; Kahn, René S; van Engeland, Herman; Kemner, Chantal

    2008-01-01

    The association between the 22q11.2 deletion syndrome (22q11DS) and psychiatric disorders, particularly psychosis, suggests a causal relationship between 22q11DS genes and abnormal brain function. The genes catechol-O-methyl-transferase (COMT) and proline dehydrogenase both reside within the commonly deleted region of 22q11.2. COMT activity and proline levels may therefore be altered in 22q11DS individuals. Associations of both COMT158 genotype and elevated serum proline levels with abnormal ...

  18. Production of Λ-hyperons in inelastic p+p interactions at 158 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Aduszkiewicz, A.; Dominik, W.; Kuich, M.; Matulewicz, T.; Posiadala, M. [University of Warsaw, Warsaw (Poland); Ali, Y. [Jagiellonian University, Cracow (Poland); COMSATS Institute of Information Technology, Department of Physics, Islamabad (Pakistan); Andronov, E.; Feofilov, G.A.; Igolkin, S.; Kondratiev, V.P.; Seryakov, A.; Vechernin, V.V.; Vinogradov, L. [St. Petersburg State University, St. Petersburg (Russian Federation); Anticic, T.; Kadija, K. [Ruder Boskovic Institute, Zagreb (Croatia); Antoniou, N.; Christakoglou, P.; Davis, N.; Diakonos, F.; Kapoyannis, A.; Panagiotou, A.D.; Vassiliou, M. [University of Athens, Athens (Greece); Baatar, B.; Bunyatov, S.A.; Kolesnikov, V.I.; Krasnoperov, A.; Lyubushkin, V.V.; Malakhov, A.I.; Matveev, V.; Melkumov, G.L.; Tereshchenko, V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Bay, F.; Di Luise, S.; Rubbia, A.; Sgalaberna, D. [ETH Zuerich, Zuerich (Switzerland); Blondel, A.; Bravar, A.; Damyanova, A.; Haesler, A.; Korzenev, A.; Ravonel, M. [University of Geneva, Geneva (Switzerland); Bogomilov, M.; Kolev, D.; Tsenov, R. [University of Sofia, Faculty of Physics, Sofia (Bulgaria); Brandin, A.; Selyuzhenkov, I.; Taranenko, A. [National Research Nuclear University ' ' MEPhI' ' (Moscow Engineering Physics Institute), Moscow (Russian Federation); Brzychczyk, J.; Larsen, D.; Planeta, R.; Richter-Was, E.; Staszel, P.; Wyszynski, O. [Jagiellonian University, Cracow (Poland); Busygina, O.; Golubeva, M.; Guber, F.; Ivashkin, A.; Kurepin, A.; Sadovsky, A. [Institute for Nuclear Research, Moscow (Russian Federation); Cirkovic, M.; Manic, D.; Puzovic, J. [University of Belgrade, Belgrade (Serbia); Czopowicz, T.; Dynowski, K.; Grebieszkow, K.; Mackowiak-Pawlowska, M.; Maksiak, B.; Slodkowski, M.; Tefelski, D. [Warsaw University of Technology, Warsaw (Poland); Dembinski, H.; Engel, R.; Herve, A.E.; Mathes, H.J.; Roth, M.; Szuba, M.; Ulrich, R.; Unger, M.; Veberic, D. [Karlsruhe Institute of Technology, Karlsruhe (Germany); Deveaux, M.; Koziel, M.; Renfordt, R.; Stroebele, H. [University of Frankfurt, Frankfurt (Germany); Dumarchez, J.; Robert, A. [University of Paris VI and VII, LPNHE, Paris (France); Ereditato, A.; Hierholzer, M.; Nirkko, M.; Pistillo, C.; Redij, A. [University of Bern, Bern (Switzerland); Fodor, Z. [Wigner Research Centre for Physics of the Hungarian Academy of Sciences, Budapest (Hungary); University of Wroclaw, Wroclaw (Poland); Garibov, A. [National Nuclear Research Center, Baku (Azerbaijan); Gazdzicki, M. [University of Frankfurt, Frankfurt (Germany); Jan Kochanowski University in Kielce, Kielce (Poland); Grzeszczuk, A.; Kaptur, E.; Kisiel, J.; Kowalski, S.; Pulawski, S.; Schmidt, K.; Wilczek, A. [University of Silesia, Katowice (Poland); Hasegawa, T.; Kobayashi, T.; Nakadaira, T.; Nishikawa, K.; Sakashita, K.; Sekiguchi, T.; Shibata, M.; Tada, M. [Institute for Particle and Nuclear Studies, Tsukuba (Japan); Johnson, S.R.; Marino, A.D.; Nagai, Y.; Rumberger, B.T.; Zimmerman, E.D. [University of Colorado, Boulder (United States); Kowalik, K.; Rondio, E.; Stepaniak, J. [National Centre for Nuclear Research, Warsaw (Poland); Laszlo, A.; Marton, K.; Vesztergombi, G. [Wigner Research Centre for Physics of the Hungarian Academy of Sciences, Budapest (Hungary); Lewicki, M.; Naskret, M.; Turko, L. [University of Wroclaw, Wroclaw (Poland); Marcinek, A. [Jagiellonian University, Cracow (Poland); University of Wroclaw, Wroclaw (Poland); Messerly, B.; Paolone, V. [University of Pittsburgh, Pittsburgh (United States); Mills, G.B. [Los Alamos National Laboratory, Los Alamos (United States); Morozov, S.; Petukhov, O. [Institute for Nuclear Research, Moscow (Russian Federation); National Research Nuclear University ' ' MEPhI' ' (Moscow Engineering Physics Institute), Moscow (Russian Federation); Mrowczynski, S.; Rybczynski, M.; Seyboth, P.; Stefanek, G.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A. [Jan Kochanowski University in Kielce, Kielce (Poland); Pavin, M. [Ruder Boskovic Institute, Zagreb (Croatia); University of Paris VI and VII, LPNHE, Paris (France); Popov, B.A. [University of Paris VI and VII, LPNHE, Paris (France); Joint Institute for Nuclear Research, Dubna (Russian Federation); Rauch, W. [Fachhochschule Frankfurt, Frankfurt (Germany); Roehrich, D. [University of Bergen, Bergen (Norway); Rustamov, A. [National Nuclear Research Center, Baku (Azerbaijan); University of Frankfurt, Frankfurt (Germany); Susa, T. [Ruder Boskovic Institute, Zagreb (Croatia); Zambelli, L. [University of Paris VI and VII, LPNHE, Paris (France); Institute for Particle and Nuclear Studies, Tsukuba (Japan); Collaboration: NA61/SHINE Collaboration

    2016-04-15

    Inclusive production of Λ-hyperons was measured with the large acceptance NA61/SHINE spectrometer at the CERN SPS in inelastic p+p interactions at beam momentum of 158 GeV/c. Spectra of transverse momentum and transverse mass as well as distributions of rapidity and x{sub F} are presented. The mean multiplicity was estimated to be 0.120 ± 0.006(stat.) ± 0.010(sys.). The results are compared with previous measurements and predictions of the Epos, Urqmd and Fritiof models. (orig.)

  19. Scaling of Particle and Transverse Energy Production in 208Pb+208Pb collisions at 158 A GeV

    CERN Document Server

    Aggarwal, M M; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Baldin, A; Barabash, L; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Delagrange, H; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S K; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Frolov, V; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Kim, H; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Martínez, G; Maksimov, A; Mehdiyev, R; Mgebrishvili, G; Miake, Y; Mikhalev, D; Mir, M F; Mishra, G C; Miyamoto, Y; Mohanty, B; Mora, M J; Morrison, D; Mukhopadhyay, D S; Myalkovskii, V; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Parfenov, A; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Plasil, F; Pinganaud, W; Purschke, M L; Räven, B; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Tykarski, L; Urbahn, J; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    2001-01-01

    Transverse energy, charged particle, and photon pseudorapidity distributions have been studied as a function of the number of participants (N_{part}) and the number of binary nucleon-nucleon collisions (N_{coll}) in 158 A GeV Pb+Pb collisions over a wide impact parameter range. A scaling of the transverse energy and charged particle pseudorapidity density at midrapidity as N_{part}^{1.08} and N_{coll}^{0.83} is observed. This faster than linear scaling with N_{part} indicates a violation of the naive Wounded Nucleon Model.

  20. One-, two- and three-particle distributions from central Pb+Pb collisions at 158A GeV/c

    CERN Document Server

    Rosselet, L; Agnihotri, A; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bock, R; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Delagrange, H; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Ganti, M S; Garpman, S; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Klein-Bösing, C; Knoche, S; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Martínez, G; Maksimov, A; Mgebrishvili, G; Miake, Y; Mir, M F; Mishra, G C; Miyamoto, Y; Mohanty, B; Mora, M J; Morrison, D; Mukhopadhyay, D S; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Pinganaud, W; Plasil, F; Von Poblotzki, U; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Tykarski, L; Urbahn, J; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    2002-01-01

    The WA98 experiment at the CERN SPS combines large acceptance photon detectors with a two-arm charged particle tracking spectrometer to study 158A GeV Pb+Pb collisions.We present results from one-, two- and three-particle analyses for charged particles identified with a time of flight system. The rapidity acceptance for pions in the first (second) arm ranged from y=2.1 (2.6) to 3.1 (3.8) with an average at 2.7 (3.2), close to mid-rapidity which was 2.9. (11 refs).

  1. Transverse mass distributions of neutral pions from $^{208}$Pb-induced reactions at 158$\\cdot A$ GeV

    CERN Document Server

    Aggarwal, M.M.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bucher, D.; Busching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M.P.; Delagrange, H.; Donni, P.; Dutta Majumdar, M.R.; El Chenawi, K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Karadjev, K.; Karpio, K.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Lohner, H.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G.C.; Mohanty, B.; Mora, M.J.; Morrison, Douglas R.O.; Mukhanova, T.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Plasil, F.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Rubio, J.M.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; Van den Pijll, E.C.; Van Eijndhoven, N.; Van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.S.; Voros, S.; Wyslouch, B.; Young, G.R.

    2002-01-01

    Results on transverse mass spectra of neutral pions measured at central rapidity are presented for impact parameter selected 158$\\cdot A$ GeV Pb + Pb, and Pb + Nb collisions. The distributions cover the range $0.5 \\mathrm{GeV}/c^{2} \\le m_{T} - m_{0} \\le 4 \\mathrm{GeV}/c^{2}$. The change of the spectral shape with centrality is studied in detail. In going from peripheral to medium central collisions there is a nuclear enhancement increasing with transverse mass similar to the well known Cronin effect, while for very central collisions this enhancement appears to be weaker than expected.

  2. Recent results on anomalous J/psi suppression in Pb-Pb collisions at 158 AGeV/c

    CERN Document Server

    Santos, Helena; Alexa, C.; Arnaldi, R.; Atayan, M.; Baglin, C.; Baldit, A.; Bedjidian, M.; Beole, S.; Boldea, V.; Bordalo, P.; Borenstein, S.R.; Borges, G.; Bussiere, A.; Capelli, L.; Castanier, C.; Castor, J.; Chaurand, B.; Cheynis, B.; Chiavassa, E.; Cicalo, C.; Claudino, T.; Comets, M.P.; Constantinescu, S.; Cortese, P.; Cruz, J.; De Falco, A.; De Marco, N.; Dellacasa, G.; Devaux, A.; Dita, S.; Drapier, O.; Espagnon, B.; Fargeix, J.; Force, P.; Gallio, M.; Gavrilov, Y.K.; Gerschel, C.; Giubellino, P.; Golubeva, M.B.; Gonin, M.; Grigorian, A.A.; Grigorian, S.; Grossiord, J.Y.; Guber, F.F.; Guichard, A.; Gulkanyan, H.; Hakobyan, R.; Haroutunian, R.; Idzik, M.; Jouan, D.; Karavitcheva, T.L.; Kluberg, L.; Kurepin, A.B.; Le Bornec, Y.; Lourenco, C.; Macciotta, P.; Cormick, M.Mac; Marzari-Chiesa, A.; Masera, M.; Masoni, A.; Monteno, M.; Musso, A.; Petiau, P.; Piccotti, A.; Pizzi, J.R.; Prado da Silva, W.L.; Prino, F.; Puddu, G.; Quintans, C.; Ramello, L.; Ramos, S.; Rato Mendes, P.; Riccati, L.; Romana, A.; Saturnini, P.; Scalas, E.; Scomparin, E.; Serci, S.; Shahoyan, R.; Sigaudo, F.; Sitta, M.; Sonderegger, P.; Tarrago, X.; Topilskaya, N.S.; Usai, G.L.; Vercellin, E.; Villatte, L.; Willis, N.; Wu, T.

    2002-01-01

    We report our latest results on charmonium suppression as measured at the CERN-SPS in Pb-Pb interactions at an incident beam momentum of 158 GeV/c per nucleon. Preliminary results obtained from the most recent sample of data collected in year 2000 under improved experimental conditions are compared with published results. For the most peripheral Pb-Pb collisions, J/psi suppression agrees with the normal absorption measured from interactions of lighter nuclei while a steady increasing abnormal supression is observed with increasing centrality.

  3. Significant association of catechol-O-methyltransferase Val158Met polymorphism with bladder cancer instead of prostate and kidney cancer.

    Science.gov (United States)

    Chen, Yang; Yu, Xiaoxiang; Li, Tianyu; Yan, Haibiao; Mo, Zengnan

    2016-05-28

    Urological cancers occur worldwide. Many factors, among which the catechol-O-methyltransferase (COMT) Val158Met polymorphism, are said to be associated with the cancer risk. We conducted a meta-analysis to investigate the association between urological cancer susceptibility and COMT Val158Met in different genetic models. This study was based on material obtained from the PubMed, HuGENet and Embase databases. Four models including dominant (AA + AG vs. GG), recessive (AA vs. AG + GG), codominant (AA vs. AG, AA vs. GG) and per-allele analysis (A vs. G) were applied. Odds ratios (OR) and the corresponding 95% confidence intervals (CI) were used to evaluate the power of the associations. Fourteen eligible studies comprising 3,285 cases and 3,594 controls were included. Although we could not detect a positive function of the COMT Val158Met polymorphism in urological cancers, the polymorphism might be significantly associated with bladder cancer risk (dominant model [AA + AG vs. GG]: OR = 0.736, 95% CI = 0.586-0.925, I2 = 0.00%; recessive model [AA vs. AG + GG]: OR = 0.822, 95%CI = 0.653-1.035, I2 = 6.30%; codominant model [AA vs. AG]: OR = 0.908, 95% CI = 0.710-1.161, I2 = 0.00%; codominant model [AA vs. GG]: OR = 0.693, 95% CI = 0.524-0.917, I2 = 30.20%; allele analysis [A vs. G]: OR = 0.826, 95%CI = 0.717-0.951, I2 = 30.20%). The same significant associations were not found for kidney cancer and prostate cancer risk in different ethnicities. There also seemed to be no distinct effect of the polymorphism on benign prostatic hyperplasia. We suggest that bladder cancer but not prostate cancer and kidney cancer could be significantly associated with the Val158Met polymorphism. Interaction of COMT genetic and related environmental factors for urological cancers should not be ignored in future.

  4. Comparison of particle production in Pb(158 GeV/nucleon)-Ag/Br collisions with the VENUS and FRITIOF models

    Energy Technology Data Exchange (ETDEWEB)

    Dabrowska, A.; Holynski, R.; Kudzia, D.; Olszewski, A.; Szarska, M.; Trzupek, A.; Wilczynska, B.; Wilczynski, H.; Wolter, W.; Wosiek, B.; Wozniak, K. [Institute of Nuclear Physics, Cracow (Poland); Deines-Jones, P.; Nilsen, B.S.; Wefel, J.P. [Louisiana State Univ., Baton Rouge, LA (United States); Waddington, C.J. [Univ. of Minnesota, Minneapolis, MN (United States)

    1998-04-13

    Data on multiparticle production in interactions of 158 GeV/nucleon lead ions with the heavy nuclei in emulsions (Ag,Br) are compared with the predictions of the VENUS and FRITIOF models. It is found that total multiplicities of produced charged particles are reasonably well reproduced by both models. On the other hand, discrepancies between the data and the predictions are observed for the forward charge and pseudorapidity distributions. Furthermore, dynamical fluctuations, revealed in the data by application of the method of factorial moments, are absent from the model simulations. The dynamical fluctuations observed in the data can be at least partly due to Bose-Einstein correlations. (orig.) 19 refs.

  5. Electric charge fluctuations in central Pb+Pb collisions at 20, 30, 40, 80 and 158 AGeV

    CERN Document Server

    Anticic, T; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-01-01

    Results are presented on event-by-event electric charge fluctuations in central Pb+Pb collisions at 20, 30, 40, 80 and 158 AGeV. The observed fluctuations are close to those expected for a gas of pions correlated by global charge conservation only. These fluctuations are considerably larger than those calculated for an ideal gas of deconfined quarks and gluons. The present measurements do not necessarily exclude reduced fluctuations from a quark-gluon plasma because these might be masked by contributions from resonance decays.

  6. Lambda and lambda production in central Pb-Pb collisions at 40, 80, and 158A GeV.

    Science.gov (United States)

    Anticic, T; Baatar, B; Barna, D; Bartke, J; Behler, M; Betev, L; Białkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncić, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gaździcki, M; Georgopoulos, G; Gładysz, E; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; van Leeuwen, M; Lévai, P; Litov, L; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczyński, St; Pálla, G; Panagiotou, A D; Panayotov, D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R; Retyk, W; Roland, C; Roland, G; Rybczyński, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitar, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, M; Veres, G I; Vesztergombi, G; Vranić, D; Wetzler, A; Włodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-07-09

    Production of Lambda and Antilambda hyperons was measured in central Pb-Pb collisions at 40, 80, and 158A GeV beam energy on a fixed target. Transverse mass spectra and rapidity distributions are given for all three energies. The Lambda/pi ratio at midrapidity and in full phase space shows a pronounced maximum between the highest BNL Alternating Gradient Synchrotron and 40A GeV CERN Super Proton Synchrotron energies, whereas the Lambda/pi ratio exhibits a monotonic increase.

  7. Influence of COMT val158met genotype on the depressed brain during emotional processing and working memory.

    Directory of Open Access Journals (Sweden)

    Esther M Opmeer

    Full Text Available Major depressive disorder (MDD has been associated with abnormal prefrontal-limbic interactions and altered catecholaminergic neurotransmission. The val158met polymorphism on the catechol-O-methyltransferase (COMT gene has been shown to influence prefrontal cortex (PFC activation during both emotional processing and working memory (WM. Although COMT-genotype is not directly associated with MDD, it may affect MDD pathology by altering PFC activation, an endophenotype associated with both COMT and MDD. 125 participants, including healthy controls (HC, n=28 and MDD patients were genotyped for the COMT val158met polymorphism and underwent functional magnetic resonance imaging (fMRI-neuroimaging during emotion processing (viewing of emotional facial expressions and a WM task (visuospatial planning. Within HC, we observed a positive correlation between the number of met-alleles and right inferior frontal gyrus activation during emotional processing, whereas within patients the number of met-alleles was not correlated with PFC activation. During WM a negative correlation between the number of met-alleles and middle frontal gyrus activation was present in the total sample. In addition, during emotional processing there was an effect of genotype in a cluster including the amygdala and hippocampus. These results demonstrate that COMT genotype is associated with relevant endophenotypes for MDD. In addition, presence of MDD only interacts with genotype during emotional processing and not working memory.

  8. TRITEX. A ferritic steel loop with Pb-15.8Li. Behavior of metals and corrosion products

    Energy Technology Data Exchange (ETDEWEB)

    Feuerstein, H.; Hoerner, L.; Horn, S.; Bucke, S. [Marburg Univ. (Germany). Inst. fuer Biopharmazie und Pharmazeutische Technologie

    1999-06-01

    TRITEX was a pumped loop with Pb-15.8Li, operated for 13000 hours at temperatures between 260 and 480 C. Many features were comparable to ITER blankets. The behavior of metals and corrosion products were investigated, and different purification devices tested. In spite of good wetting, drain of Pb-15.8Li left a residue film of 87 mg/cm{sup 2} on surfaces. In TRITEX 1 kg or 1% of the inventory was not drained. Generally structural materials showed the expected behavior. For {alpha}-iron a volume swelling by 5% was observed, an effect not described before. A H{sub 2} background in all covergas spaces was caused by the reaction of steel 1.4922 with humidity. This has to be considered in experiments with low concentrations of deuterium or tritium. The behavior of lithium is of special concern. Because of an initially hyper-eutectic mixture, LiPb with a melting point of 482 C was formed and deposited, flow blocking in some parts observed. On the other hand, the Li concentration can easily be controlled by a simple diffusion cold trap with a solid phase, e.g. with freeze valves. But also a lead phase was found and has to be considered when designing systems. 118 grams Corrosion Products in form of particles with different compositions were formed. The chemistry of corrosion products was complex, even compounds like NiMn and Ni{sub 1.22-1.9}V were identified. Because of the density difference to the eutectic mixture, a fraction floated to liquid metal/covergas interfaces. 78% of particles were magnetic, but only 30% were trapped in magnetic fields. Cold traps were effective because of hydraulic conditions and not because of low temperature. Purification devices trapped also LiPb. Always more than 90% of deposited material was a mixture of LiPb and Pb-15.8Li. In TRITEX bismuth concentrations in the circulating mixture were below 10 wppm. Any excess was deposited at liquid/solid phase boundaries. The concentrations of Cu, Ag and Zn in circulating Pb-15.8Li were unchanged

  9. Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender.

    Science.gov (United States)

    Klein, Martina; Schmoeger, Michaela; Kasper, Siegfried; Schosser, Alexandra

    2016-01-01

    Many studies have reported an association of the COMT Val158Met polymorphism and major depressive disorder (MDD), although with conflicting results. The role of gender is a possible modulator. To overcome the problem of poor sample size detecting genes of small effect, we perform a meta-analysis of the current literature, investigating the influence of the COMT Val158Met polymorphism on the pathogenesis of MDD, with a major focus on the effect of gender. Out of 977 retrieved articles, 21 included case-control studies allowed the analysis of 9005 patients with MDD and 12,095 controls. Allelic and genotypic pooled odds ratios (OR) were calculated for the total sample and gender-subgroups. In the absence of publication bias, allelic and genotypic analyses showed no significant association in the total sample, as well as in gender-specific subgroups. Sensitivity analysis did not alter the ORs. The results imply a complex nature of the genotype × phenotype interaction. Further studies of the COMT gene or the locus remain to be justified given the important positional and functional relevance and the plethora of gender-specific findings. A possible way to further dissect this topic is shifting the focus to gene-based or genome-wide analyses of intermediate phenotypes.

  10. Catechol-O-Methyltransferase (COMT Val108/158 Met polymorphism does not modulate executive function in children with ADHD

    Directory of Open Access Journals (Sweden)

    Stepanian Marina

    2004-12-01

    Full Text Available Abstract Background An association has been observed between the catechol-O-methyltransferase (COMT gene, the predominant means of catecholamine catabolism within the prefrontal cortex (PFC, and neuropsychological task performance in healthy and schizophrenic adults. Since several of the cognitive functions typically deficient in children with Attention Deficit Hyperactivity Disorder (ADHD are mediated by prefrontal dopamine (DA mechanisms, we investigated the relationship between a functional polymorphism of the COMT gene and neuropsychological task performance in these children. Methods The Val108/158 Met polymorphism of the COMT gene was genotyped in 118 children with ADHD (DSM-IV. The Wisconsin Card Sorting Test (WCST, Tower of London (TOL, and Self-Ordered Pointing Task (SOPT were employed to evaluate executive functions. Neuropsychological task performance was compared across genotype groups using analysis of variance. Results ADHD children with the Val/Val, Val/Met and Met/Met genotypes were similar with regard to demographic and clinical characteristics. No genotype effects were observed for WCST standardized perseverative error scores [F2,97 = 0.67; p > 0.05], TOL standardized scores [F2,99 = 0.97; p > 0.05], and SOPT error scores [F2,108 = 0.62; p > 0.05]. Conclusions Contrary to the observed association between WCST performance and the Val108/158 Met polymorphism of the COMT gene in both healthy and schizophrenic adults, this polymorphism does not appear to modulate executive functions in children with ADHD.

  11. The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives.

    Science.gov (United States)

    Lelli-Chiesa, G; Kempton, M J; Jogia, J; Tatarelli, R; Girardi, P; Powell, J; Collier, D A; Frangou, S

    2011-04-01

    The Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala-prefrontal cortical (PFC) networks. It is also thought to increase the risk of a number of disorders characterized by affective morbidity including bipolar disorder (BD), major depressive disorder (MDD) and anxiety disorders. The disease risk conferred is small, suggesting that this polymorphism represents a modifier locus. Therefore our aim was to investigate how the COMT Val158Met may contribute to phenotypic variation in clinical diagnosis using sad facial affect processing as a probe for its neural action. We employed functional magnetic resonance imaging to measure activation in the amygdala, ventromedial PFC (vmPFC) and ventrolateral PFC (vlPFC) during sad facial affect processing in family members with BD (n=40), MDD and anxiety disorders (n=22) or no psychiatric diagnosis (n=25) and 50 healthy controls. Irrespective of clinical phenotype, the Val158 allele was associated with greater amygdala activation and the Met158 allele with greater signal change in the vmPFC and vlPFC. Signal changes in the amygdala and vmPFC were not associated with disease expression. However, in the right vlPFC the Met158 allele was associated with greater activation in all family members with affective morbidity compared with relatives without a psychiatric diagnosis and healthy controls. Our results suggest that the COMT Val158Met polymorphism has a pleiotropic effect within the neural networks subserving emotional processing. Furthermore the Met158 allele further reduces cortical efficiency in the vlPFC in individuals with affective morbidity.

  12. Association of catechol-O-methyltransferase Val(108/158) Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population.

    Science.gov (United States)

    Mao, Qiao; Tan, Yun-Long; Luo, Xing-Guang; Tian, Li; Wang, Zhi-Ren; Tan, Shu-Ping; Chen, Song; Yang, Gui-Gang; An, Hui-Mei; Yang, Fu-De; Zhang, Xiang-Yang

    2016-08-30

    Catechol-O-methyltransferase (COMT), an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, is associated with the sensory gating phenomenon, protecting the cerebral cortex from information overload. The COMT Val(108/158)Met polymorphism is essential for prefrontal cortex processing capacity and efficiency. The current study was designed to investigate the role of COMT Val(108/158)Met polymorphism in development, sensory gating deficit, and symptoms of schizophrenia in Han Chinese population. P50 gating was determined in 139 schizophrenic patients and 165 healthy controls. Positive and Negative Syndrome Scale (PANSS) was used to assess the clinical symptomatology in 370 schizophrenic subjects. COMT Val(108/158)Met polymorphism was genotyped by PCR-restriction fragment length polymorphism (PCR-RFLP). No significant differences in COMT allele and genotype distributions were observed between schizophrenic patients and control groups. Although P50 deficits were present in patients, there was no evidence for an association between COMT Val(108/158)Met polymorphism and the P50 biomarker. Moreover, PANSS negative subscore was significantly higher in Val allele carriers than in Met/Met individuals. The present findings suggest that COMT Val(108/158)Met polymorphism may not contribute to the risk of schizophrenia and to the P50 deficits, but may contribute to the negative symptoms of schizophrenia among Han Chinese. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  13. The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study

    Directory of Open Access Journals (Sweden)

    Skorpen Frank

    2007-06-01

    Full Text Available Abstract Background The catechol-O-methyltransferase (COMT gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction. Whether the Val158Met polymorphism is associated with survival has not been evaluated in the general population. The aim of this prospective study was to evaluate the impact of codon 158 COMT gene polymorphism on survival in a population-based cohort. Methods The sample comprised 2979 non-diabetic individuals who participated in the Nord-Trøndelag Health Study (HUNT in the period 1995–97. The subjects were followed up with respect to mortality throughout year 2004. Results 212 men and 183 women died during the follow up. No association between codon 158 COMT gene polymorphism and survival was found. The unadjusted relative risk of death by non-ischemic heart diseases with Met/Met or Met/Val genotypes was 3.27 (95% confidence interval, 1.19–9.00 compared to Val/Val genotype. When we adjusted for age, gender, smoking, coffee intake and body mass index the relative risk decreased to 2.89 (95% confidence interval, 1.04–8.00. Conclusion During 10 year of follow-up, the Val158Met polymorphism had no impact on survival in a general population. Difference in mortality rates from non-ischemic heart diseases may be incidental and should be evaluated in other studies.

  14. Modificación del recalentador de las unidades de 158 MW para evitar el desalineamiento de sus serpentines // Modification of the158 MW steam superheater of the units in order to avoid the coils misalignment.

    Directory of Open Access Journals (Sweden)

    V. Fabelo Susé

    2000-07-01

    Full Text Available El presente trabajo pretende mostrar como resolver la tendencia al desalineamiento de los lazos del recalentador de vaporde las unidades de 155 MW de la central termoeléctrica “Carlos M. Céspedes”. Aquí se hace un esbozo de los problemasconfrontados por este agregado. Se abordan las causas y consecuencias del desalineamiento. Finalmente se hace lapropuesta de modificación avalada por un cálculo de termotransferencia.Palabras claves: desalineamiento, recalentador de vapor, termotransferencia.__________________________________________________________________________AbstractThe present work expose show to solve the tendency to misalignment of the loops in a 158 MW steam superheater units ina thermoelectric power plant. A sketch of the problems confronted by this equipment is presented. The causes andconsequences of the misalignment are approached. Finally, the modification proposal is made checked by atermotransference calculation.Key words: Steam superheater, coils misalignment, termotransference calculation.

  15. [Analysis of clinical characteristic of 158 inpatients with dengue fever in Guangzhou area during the 2014 epidemic].

    Science.gov (United States)

    Ye, Zi; Huang, Yingxiong; Jiang, Peng; Zheng, Ziyu; Xiong, Yan; Xu, Jia; Xiao, Xiaoyong; Zhan, Hong

    2015-04-01

    To investigate the clinical characteristics of the inpatients suffering from dengue fever in order to provide references for better diagnosis and treatment. The clinical data of 158 dengue fever patients admitted to the First Affiliated Hospital of Sun Yat-Sen University from July 23rd to October 31st, 2014 during the 2014 epidemic in Guangzhou area were retrospectively analyzed, including general clinical manifestations, conventional examinations, pathogenesis, and prognosis. The mean age of the 158 patients was ( 56 ± 20 ) years, with half of them over 60 years old (79 cases). Among them, 94 (59.49%) were male. (1) The common manifestations included fever (100%), headache (70.89%), myalgia/bone soreness (62.03%), and skin rash (54.43%). Bleeding and plasma leakage were found in 25.95% and 14.56% of the patients respectively. (2) Laboratory examination: leucopenia (75.32%) and thrombocytopenia (77.85%) were found, and alanine aminotransferase (ALT) and aspartate aminotransferase ( AST ) were elevated in 57.59% and 77.85% of the patients respectively. However, elevation of blood hematocrit was rare (1.27% ). (3) It was found that in the acute phase (0 - 5 days of the onset), serum dengue virus antibody IgM (DF-IgM) was positive in 63.54% of the patients (61/96), and 92.62% (113/122) of patients were dengue virus RNA ( DENA-RNA ) positive. (4) The rate of comorbidity in this study was 55.06% ( 87/158 ), including hypertension (27.22%) and type 2 diabetes (15.82%), which were the two most common co-morbidities. (5) All the patients were given supportive therapy to prevent complications. They were also isolated for more than 5 days after onset, and at least for 24 hours after subsidence of fever in addition. (6) The criteria for the diagnosis of severe dengue were fulfilled in 18 patients (11.39%). One patient died of massive hemorrhage from gastro-intestinal tract, and 1 patient voluntarily left hospital with untreated multiple organ dysfunction syndrome (MODS

  16. Critical fluctuations of the proton density in A+A collisions at $158A$ GeV

    CERN Document Server

    Anticic, T.; Bartke, J.; Beck, H.; Betev, L.; Białkowska, H.; Blume, C.; Bogusz, M.; Boimska, B.; Book, J.; Botje, M.; Bunčić, P.; Cetner, T.; Christakoglou, P.; Chvala, O.; Cramer, J.; Eckardt, V.; Fodor, Z.; Foka, P.; Friese, V.; Gaździcki, M.; Grebieszkow, K.; Höhne, C.; Kadija, K.; Karev, A.; Kolesnikov, V.I.; Kowalski, M.; Kresan, D.; Laszlo, A.; Leeuwen, M.; Maćkowiak-Pawłowska, M.; Makariev, M.; Malakhov, A.I.; Mateev, M.; Melkumov, G.L.; Mitrovski, M.; Mrówczyński, St.; Pálla, G.; Panagiotou, A.D.; Peryt, W.; Pluta, J.; Prindle, D.; Pühlhofer, F.; Renfordt, R.; Roland, C.; Roland, G.; Rustamov, A.; Rybczyński, M.; Rybicki, A.; Sandoval, A.; Schmitz, N.; Schuster, T.; Seyboth, P.; Siklér, F.; Skrzypczak, E.; Slodkowski, M.; Stefanek, G.; Stock, R.; Ströbele, H.; Susa, T.; Szuba, M.; Varga, D.; Vassiliou, M.; Veres, G.I.; Vesztergombi, G.; Vranić, D.; Włodarczyk, Z.; Wojtaszek-Szwarć, A.; Antoniou, N.G.; Davis, N.; Diakonos, F.K.

    2015-12-12

    Studies of QCD suggest the existence of a critical point in the phase diagram of strongly interacting matter. Close to this point, according to recent theoretical investigations, the net-proton density carries the critical fluctuations of the chiral order parameter. Using intermittency analysis in the transverse momentum phase space of protons produced around midrapidity in the 12.5% most central C+C, Si+Si and Pb+Pb collisions at the maximum SPS energy of 158$A$ GeV we find evidence of power-law fluctuations for the Si+Si and Pb+Pb data. The fitted power-law exponent approaches the value expected for critical fluctuations. This suggests that the freeze-out states of these two systems are located in the phase diagram in the neighbourhood of the chiral critical point.

  17. Critical fluctuations of the proton density in A+A collisions at 158A GeV

    Energy Technology Data Exchange (ETDEWEB)

    Anticic, T.; Kadija, K.; Susa, T. [Rudjer Boskovic Institute, Zagreb (Croatia); Baatar, B.; Kolesnikov, V.I.; Malakhov, A.I.; Melkumov, G.L. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Bartke, J.; Kowalski, M.; Rybicki, A. [Polish Academy of Science, H. Niewodniczanski Institute of Nuclear Physics, Cracow (Poland); Beck, H.; Blume, C.; Book, J.; Mitrovski, M.; Renfordt, R.; Rustamov, A.; Schuster, T.; Stock, R.; Stroebele, H. [Fachbereich Physik der Universitaet, Frankfurt (Germany); Betev, L.; Buncic, P.; Karev, A. [CERN, Geneva (Switzerland); Bialkowska, H.; Boimska, B. [National Center for Nuclear Research, Warsaw (Poland); Bogusz, M.; Cetner, T.; Grebieszkow, K.; Mackowiak-Pawlowska, M.; Peryt, W.; Pluta, J.; Slodkowski, M.; Szuba, M. [Warsaw University of Technology, Faculty of Physics, Warsaw (Poland); Botje, M.; Christakoglou, P.; Leeuwen, M. van [NIKHEF, Amsterdam (Netherlands); Chvala, O. [Charles University, Institute of Particle and Nuclear Physics, Prague (Czech Republic); Cramer, J.; Prindle, D. [University of Washington, Nuclear Physics Laboratory, Seattle, WA (United States); Eckardt, V.; Schmitz, N.; Seyboth, P. [Max-Planck-Institut fuer Physik, Munich (Germany); Fodor, Z.; Laszlo, A.; Palla, G.; Sikler, F.; Veres, G.I.; Vesztergombi, G. [Hungarian Academy of Sciences, Wigner Research Center for Physics, Budapest (Hungary); Foka, P.; Friese, V.; Hoehne, C.; Kresan, D.; Sandoval, A.; Vranic, D. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Gazdzicki, M. [Fachbereich Physik der Universitaet, Frankfurt (Germany); Jan Kochanowski University, Institute of Physics, Kielce (Poland); Makariev, M. [BAS, Institute for Nuclear Research and Nuclear Energy, Sofia (Bulgaria); Mateev, M. [Sofia University St. Kliment Ohridski, Atomic Physics Department, Sofia (Bulgaria); Mrowczynski, S.; Rybczynski, M.; Stefanek, G.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A. [Jan Kochanowski University, Institute of Physics, Kielce (Poland); Panagiotou, A.D.; Vassiliou, M.; Antoniou, N.G.; Davis, N.; Diakonos, F.K. [University of Athens, Department of Physics, Athens (Greece); Puehlhofer, F. [Fachbereich Physik der Universitaet, Marburg (Germany); Roland, C.; Roland, G. [MIT, Cambridge, MA (United States); Skrzypczak, E. [University of Warsaw, Institute for Experimental Physics, Warsaw (Poland); Varga, D. [Eoetvoes Lorant University, Budapest (Hungary); Collaboration: (NA49 Collaboration)

    2015-12-15

    We look for fluctuations expected for the QCD critical point using an intermittency analysis in the transverse momentum phase space of protons produced around midrapidity in the 12.5 % most central C+C, Si+Si and Pb+Pb collisions at the maximum SPS energy of 158A GeV. We find evidence of power-law fluctuations for the Si+Si data. The fitted power-law exponent φ{sub 2} = 0.96{sub -0.25}{sup +0.38}(stat.)±0.16(syst.) is consistent with the value expected for critical fluctuations. Power-law fluctuations had previously also been observed in low-mass π{sup +}π{sup -} pairs in the same Si+Si collisions. (orig.)

  18. Critical fluctuations of the proton density in A+A collisions at 158A GeV

    Energy Technology Data Exchange (ETDEWEB)

    Anticic, T. [Rudjer Boskovic Institute, Zagreb (Croatia); Baatar, B. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Bartke, J. [H. Niewodniczański Institute of Nuclear Physics, Polish Academy of Science, Cracow (Poland); Beck, H. [Fachbereich Physik der Universität, Frankfurt (Germany); Betev, L. [CERN, Geneva (Switzerland); and others

    2015-12-12

    We look for fluctuations expected for the QCD critical point using an intermittency analysis in the transverse momentum phase space of protons produced around midrapidity in the 12.5 % most central C+C, Si+Si and Pb+Pb collisions at the maximum SPS energy of 158A GeV. We find evidence of power-law fluctuations for the Si+Si data. The fitted power-law exponent ϕ{sub 2}=0.96{sub -0.25}{sup +0.38} (stat.)±0.16 (syst.) is consistent with the value expected for critical fluctuations. Power-law fluctuations had previously also been observed in low-mass π{sup +}π{sup -} pairs in the same Si+Si collisions.

  19. Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria.

    Science.gov (United States)

    Lajin, Bassam; Hamzeh, Abdul Rezzak; Ghabreau, Lina; Mohamed, Ali; Al Moustafa, Ala-Eddin; Alachkar, Amal

    2013-01-01

    Catechol-O-methyltransferase (COMT) inactivates catechol estrogens by methylation and thus may play a protective role against mutations induced by estrogen metabolites. In this study we investigated the relationship between the Vall58Met polymorphism in the COMT gene and breast cancer risk in a population-based case control study in Syria. We examined 135 breast cancer patients and 107 healthy controls in North Syria to determine the association between the functional genetic Val158Met polymorphism in the COMT gene and female breast cancer risk. There was no significant overall association between the COMT genotype and individual susceptibility to breast cancer. Our data suggest that there may be no overall association between the COMT genotype and breast cancer.

  20. Event-by-event charged-neutral fluctuations in Pb+Pb collisions at 158 A GeV

    Energy Technology Data Exchange (ETDEWEB)

    Aggarwal, M.M. [University of Panjab, Chandigarh 160014 (India); Ahammed, Z. [Variable Energy Cyclotron Centre, Calcutta 700 064 (India); Angelis, A.L.S. [University of Geneva, CH-1211 Geneva 4 (Switzerland); Antonenko, V. [RRC Kurchatov Institute, RU-123182 Moscow (Russian Federation); Arefiev, V.; Astakhov, V.; Avdeitchikov, V. [Joint Institute for Nuclear Research, RU-141980 Dubna (Russian Federation); Awes, T.C. [Oak Ridge National Laboratory, Oak Ridge, TN 37831-6372 (United States); Baba, P.V.K.S.; Badyal, S.K. [University of Jammu, Jammu 180001 (India); Bathe, S. [University of Muenster, D-48149 Muenster (Germany); Batiounia, B. [Joint Institute for Nuclear Research, RU-141980 Dubna (Russian Federation); Bernier, T. [SUBATECH, Ecole des Mines, Nantes (France); Bhalla, K.B. [University of Rajasthan, Jaipur 302004, Rajasthan (India); Bhatia, V.S. [University of Panjab, Chandigarh 160014 (India); Blume, C.; Bucher, D.; Buesching, H. [University of Muenster, D-48149 Muenster (Germany); Carlen, L. [Lund University, SE-221 00 Lund (Sweden); Chattopadhyay, S. [Variable Energy Cyclotron Centre, Calcutta 700 064 (India)

    2011-07-11

    Charged particles and photons have been measured in central Pb + Pb collisions at 158 A GeV in a common ({eta}-{phi})-phase space region in the WA98 experiment at the CERN SPS. The measured distributions have been analyzed to quantify the frequency with which phase space regions of varying sizes have either small or large neutral pion fraction. The measured results are compared with VENUS model simulated events and with mixed events. Events with both large and small charged-neutral fluctuations are observed to occur more frequently than expected statistically, as deduced from mixed events, or as predicted by model simulations, with the difference becoming more prominent with decreasing size of the {Delta}{eta}-{Delta}{phi} region.

  1. Centrality dependence of charged-neutral particle fluctuations in 158A GeV Pb+Pb collisions

    CERN Document Server

    Aggarwal, M.M.; Angelis, A.L.S.; Antonenko, V.; Arefev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bucher, D.; Busching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M.P.; Delagrange, H.; Donni, P.; Dutta Majumdar, M.R.; El Chenawi, K.; Dubey, A.K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Karadjev, K.; Karpio, K.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G.C.; Mohanty, B.; Mora, M.J.; Morrison, D.; Mukhanova, T.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Pinganaud, W.; Plasil, F.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; van de Pijll, E.C.; van Eijndhoven, N.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.S.; Voros, S.; Wyslouch, B.; Young, G.R.

    2003-01-01

    Results on the study of localized fluctuations in the multiplicity of charged particles and photons produce 158A GeV/c Pb+Pb collisions are presented for four different centrality classes. The charged versus neutral particle multiplicity correlations in common phase space regions of varying azimuthal size are analyzed by two different methods. Various types of mixed events are constructed to probe fluctuations arising from different sources. The measured results are compared to those from simulations and from mixed events. The comparison indicates the presence of non-statistical fluctuations in both the charged particle and photon multiplicities in limited azimuthal regions which decrease with decrease in centrality. However, no correlated charged-neutral fluctuations, a possible signature of formation of disoriented chiral condensates, are observed. An upper limit on the production of disoriented chiral condensates has been set.

  2. Centrality Dependence of Neutral Pion Production in 158 A GeV $^{208}Pb +^{208}Pb$ Collisions

    CERN Document Server

    Aggarwal, M.M.; Ahammed, Z.; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Baldine, A.; Barabach, L.; Barlag, C.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bock, R.; Bohne, E.-M.; Borocz, Z.K.; Bucher, D.; Buijs, A.; Busching, H.; Carlen, L.; Chalyshev, V.; Chattopadhyay, S.; Cherbatchev, R.; Chujo, T.; Claussen, A.; Das, A.C.; Decowski, M.P.; Djordjadze, V.; Donni, P.; Doubovik, I.; Dutta Majumdar, M.R.; El Chenawi, K.; Eliseev, S.; Enosawa, K.; Foka, P.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Gupta, S.K.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Higuchi, R.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Kampert, K.-H.; Karadjev, K.; Karpio, K.; Kato, S.; Kees, S.; Kim, H.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Krumpel, T.; Kugler, A.; Kulinich, P.; Kurata, M.; Kurita, K.; Kuzmin, N.; Langbein, I.; Lebedev, A.; Lee, Y.Y.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Maximov, A.; Mehdiyev, R.; Mgebrichvili, G.; Miake, Y.; Mikhalev, D.; Mishra, G.C.; Miyamoto, Y.; Morrison, D.; Mukhopadhyay, D.S.; Myalkovski, V.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Neumaier, S.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Obenshain, F.E.; Oskarsson, A.; Otterlund, I.; Pachr, M.; Parfenov, A.; Pavliouk, S.; Pietzmann, T.; Patracek, V.; Pinanaud, W.; Plasil, F.; Purschke, M.L.; Raeven, B.; Rak, J.; Raniwala, R.; Raniwala, S.; Ramamurthy, V.S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sako, H.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.-R.; Shabratova, G.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Solomey, N.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Stuken, D.; Sumbera, M.; Svensson, T.; Trivedi, M.D.; Tsvetkov, A.; Twenhofel, C.; Tykarski, L.; Urbahn, J.; Eijndhoven, N.v.; Nieuwenhuizen, G.J.v.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.; Voros, S.; Wyslouch, B.; Yagi, K.; Yokota, Y.; Young, G.R.

    1998-01-01

    The production of neutral pions in 158AGeV Pb+Pb collisions has been studied in the WA98 experiment at the CERN SPS. Transverse momentum spectra are studied for the range 0.3 GeV/c < mT-m0 < 4.0 GeV/c. The results for central collisions are compared to various models. The centrality dependence of the neutral pion spectral shape and yield is investigated. An invariance of the spectral shape and a simple scaling of the yield with the number of participating nucleons is observed for centralities with greater than about 30 participating nucleons which is most naturally explained by assuming an equilibrated system.

  3. Systematics of inclusive photon production in 158.A GeV Pb induced reactions on Ni, Nb, and Pb targets

    CERN Document Server

    Aggarwal, M M; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Baldin, A; Barabash, L; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Böck, R K; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S K; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Frolov, V; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Kim, H; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Maksimov, A; Mehdiyev, R; Mgebrishvili, G; Miake, Y; Mikhalev, D; Mir, M F; Mishra, G C; Miyamoto, Y; Morrison, D; Mukhopadhyay, D S; Myalkovskii, V; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Parfenov, A; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Plasil, F; Pinanaud, W; Purschke, M L; Räven, B; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Twenhöfel, C; Tykarski, L; Urbahn, J; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    1999-01-01

    The multiplicity of inclusive photons has been measured on an event- by-event basis for 158.A GeV Pb induced reactions on Ni, Nb, and Pb targets. The systematics of the pseudorapidity densities at midrapidity ( rho /sub max/) and the width of the pseudorapidity distributions have been studied for varying centralities for these collisions. A power law fit to the photon yield as a function of the number of participating nucleons gives a value of 1.12+or-0.03 for the exponent. The mean transverse momentum, , of photons determined from the ratio of the measured electromagnetic transverse energy and photon multiplicity, remains almost constant with increasing rho /sub max/. Results are compared with model predictions. (29 refs).

  4. Centrality Dependence of Neutral Pion Production in 158A GeV {sup 208}Pb+{sup 208}Pb Collisions

    Energy Technology Data Exchange (ETDEWEB)

    Aggarwal, M.M.; Bhatia, V.S. [University of Panjab, Chandigarh 160014 (India); Agnihotri, A.; Bhalla, K.B.; Gupta, S.K.; Raniwala, R.; Raniwala, S. [University of Rajasthan, Jaipur 302004 (India); Ahammed, Z.; Chattopadhyay, S.; Das, A.C.; Dutta Majumdar, M.R.; Ganti, M.S.; Mukhopadhyay, D.S.; Nayak, T.K.; Sinha, B.C.; Trivedi, M.D.; Viyogi, Y.P. [Variable Energy Cyclotron Centre, Calcutta 700 064 (India); Angelis, A.L.; Donni, P.; Foka, P.; Kalechofsky, H.; Martin, M.; Naef, H.; Rosselet, L.; Rubio, J.M.; Solomey, N.; Voeroes, S. [University of Geneva, CH-1211 Geneva 4 (Switzerland); Antonenko, V.; Cherbatchev, R.; Doubovik, I.; Fokin, S.; Ippolitov, M.; Karadjev, K.; Koutcheryaev, I.; Lebedev, A.; Manko, V.; Mgebrichvili, G.; Nianine, A.; Sibiriak, I.; Tsvetkov, A.; Vinogradov, A. [RRC (Kurchatov), RU-123182 Moscow (Russia); Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Baldine, A.; Barabach, L.; Batiounia, B.; Chalyshev, V.; Djordjadze, V.; Frolov, V.; Gavrishchuk, O.; Guskov, B.; Kosarev, I.; Kuzmin, N.; Maximov, A.; Mehdiyev, R.; Mikhalev, D.; Myalkovski, V.; Nikitine, V.; Nikolaev, S.; Nomokonov, P.; Parfenov, A.; Pavliouk, S.; Roufanov, I.; Shabratova, G.; Slavine, N.; Vodopianov, A. [Joint Institute for Nuclear Research, RU-141980 Dubna (Russia); Awes, T.C.; Kim, H.; Plasil, F.; Stankus, P.; Young, G.R. [Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6372 (United States); Baba, P.V.; Badyal, S.K.; Rao, N.K.; Sambyal, S.S. [University of Jammu, Jammu 180001 (India); Barlag, C.; Bathe, S.; Blume, C.; Bohne, E.; Boeroecz, Z.K.; Bucher, D.; Buesching, H.; Claussen, A.; Glasow, R.; Kampert, K.; Kees, S.; Kruempel, T.; Pietzmann, T.; Reygers, K.; Santo, R.; Schlagheck, H.; Stueken, D. [University of Muenster, D-48149 Muenster (Germany); Bernier, T.; Gutbrod, H.H.; Luquin, L.; Nayak, S.K.; Pinanaud, W.; Retiere, F.; Roy, C. [SUBATECH, Ecole des Mines, Nantes (France); Bock, R.; Kolb, B.W.; Langbein, I.; Lee, Y.Y.; Neumaier, S.; and others

    1998-11-01

    The production of neutral pions in 158A GeV {sup 208}Pb+ {sup 208}Pb collisions has been studied in the WA98 experiment at the CERN Super Proton Synchrotron (SPS). Transverse momentum spectra are studied for the range 0.3{le}m{sub T}{minus}m{sub 0}{le}4.0 GeV /c . The results for central collisions are compared to various models. The centrality dependence of the neutral pion spectral shape and yield is investigated. An invariance of the spectral shape and a simple scaling of the yield with the number of participating nucleons is observed for centralities with greater than about 30thinspthinspparticipating nucleons. This is most naturally explained by assuming an equilibrated system. {copyright} {ital 1998} {ital The American Physical Society }

  5. Central Pb+Pb Collisions at 158 A GeV/c Studied by $\\pi^{-}\\pi^{-}$ Interferometry

    CERN Document Server

    Aggarwal, M M; Ahammed, Z; Angelis, Aris L S; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Barlag, C; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bock, R; Bohne, E M; Böröcz, Z K; Bucher, D; Buijs, A; Büsching, H; Carlén, L; Chalyshev, V; Chattopadhyay, S; Cherbachev, R; Chujo, T; Claussen, A; Das, A C; Decowski, M P; Delagrange, H; Dzhordzhadze, V; Dönni, P; Dubovik, I; Dutt, S K; Dutta-Majumdar, M R; El-Chenawi, K F; Eliseev, S; Enosawa, K; Foka, P Y; Fokin, S L; Ganti, M S; Garpman, S I A; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Sen-Gupta, S K; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Higuchi, R; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Kampert, K H; Karadzhev, K; Karpio, K; Kato, S; Kees, S; Klein-Bösing, C; Knoche, S; Kolb, B W; Kosarev, I G; Kucheryaev, I; Krümpel, T; Kugler, A; Kulinich, P A; Kurata, M; Kurita, K; Kuzmin, N A; Langbein, I; Lebedev, A; Lee, Y Y; Löhner, H; Luquin, Lionel; Mahapatra, D P; Man'ko, V I; Martin, M; Martínez, G; Maksimov, A; Mgebrishvili, G; Miake, Y; Mir, M F; Mishra, G C; Miyamoto, Y; Mohanty, B; Morrison, D; Mukhopadhyay, D S; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Neumaier, S; Nyanin, A; Nikitin, V A; Nikolaev, S; Nilsson, P O; Nishimura, S; Nomokonov, V P; Nystrand, J; Obenshain, F E; Oskarsson, A; Otterlund, I; Pachr, M; Pavlyuk, S; Peitzmann, Thomas; Petracek, V; Pinganaud, W; Plasil, F; Von Poblotzki, U; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, V S; Rao, N K; Retière, F; Reygers, K; Roland, G; Rosselet, L; Rufanov, I A; Roy, C; Rubio, J M; Sako, H; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Solomey, Nickolas; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stüken, D; Sumbera, M; Svensson, T; Trivedi, M D; Tsvetkov, A A; Tykarski, L; Urbahn, J; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, G R

    2000-01-01

    Two-particle correlations have been measured for identified negative pionsfrom central 158 AGeV Pb+Pb collisions and fitted radii of about 7 fm in alldimensions have been obtained. A multi-dimensional study of the radii as afunction of kT is presented, including a full correction for the resolutioneffects of the apparatus. The cross term Rout-long of the standard fit in theLongitudinally CoMoving System (LCMS) and the vl parameter of the generalisedYano-Koonin fit are compatible with 0, suggesting that the source undergoes aboost invariant expansion. The shapes of the correlation functions in Qinv andQspace have been analyzed in detail. They are not Gaussian but betterrepresented by exponentials. As a consequence, fitting Gaussians to thesecorrelation functions may produce different radii depending on the acceptanceof the experimental setup used for the measurement.

  6. Event-by-event charged-neutral fluctuations in Pb+Pb collisions at 158 A~GeV

    CERN Document Server

    Aggarwal, M.M.; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bucher, D.; Busching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M.P.; Delagrange, H.; Donni, P.; Dutta Majumdar, M.R.; El Chenawi, K.; Dubey, A.K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Gupta, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Karadjev, K.; Karpio, K.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Liu, H.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G.C.; Mohanty, B.; Mora, M.J.; Morrison, D.; Moukhanova, T.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Pavliouk, S.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Pinanaud, W.; Plasil, F.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; van de Pijll, E.C.; van Eijndhoven, N.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.; Voros, S.; Wyslouch, B.; Young, G.R.

    2011-01-01

    Charged particles and photons have been measured in central Pb+Pb collisions at 158 A GeV in a common ($\\eta$ - $\\phi$)-phase space region in the WA98 experiment at the CERN SPS. The measured distributions have been analyzed %using the sliding window method in order to quantify the frequency with which phase space regions of varying sizes have either small or large neutral pion fraction. The measured results are compared with VENUS model simulated events and with mixed events. Events with both large and small charged-neutral fluctuations are observed to occur more frequently than expected statistically, as deduced from mixed events, or as predicted by model simulations, with the difference becoming more prominent with decreasing size of the $\\Delta\\eta$ - $\\Delta\\phi$ region.

  7. Far-infrared spectroscopy of galaxies - The 158 micron C(+) line and the energy balance of molecular clouds

    Science.gov (United States)

    Crawford, M. K.; Genzel, R.; Townes, C. H.; Watson, D. M.

    1985-01-01

    Observations of the 158 microns fine-structure line of C(+) toward the nuclei of six gas-rich galaxies are presented. The observations are compared with observations of the CO J = 1-0 and H I 21 cm lines, observations of far-IR continuum emission, and observations of forbidden C II emission with the Galaxy. The forbidden C II line comes from dense, warm gas in UV-illuminated photodissociation regions at the surfaces of molecular clouds. This line is probably optically thin in all but the brightest of galactic sources. The variation of forbidden C II brightness from source to source and its ratio to the integrated infrared continuum intensity agree well with the theoretical prediction that UV absorption by dust controls the C(+) column density. The forbidden C II line is a tracer of molecular clouds, especially those near intense sources of UV radiation.

  8. System size dependence of particle-ratio fluctuations in Pb+Pb collisions at 158$A$ GeV

    CERN Document Server

    Anticic, T; Barna, D; Bartke, J; Beck, H; Betev, L; Bialkowska, H; Blume, C; Bogusz, M; Boimska, B; Book, J; Botje, M; Buncic, P; Cetner, T; Christakoglou, P; Chung, P; Chvala, O; Cramer, J G; Eckardt, V; Fodor, Z; Foka, P; Friese, V; Gazdzicki, M; Grebieszkow, K; Hohne, C; Kadija, K; Karev, A; Kolesnikov, V I; Kollegger, T; Kowalski, M; Kresan, D; Laszlo, A; Lacey, R; van Leeuwen, M; Mackowiak-Pawlowska, M; Makariev, M; Malakhov, A I; Mateev, M; Melkumov, G L; Mitrovski, M; Mrowczynski, St; Nicolic, V; Palla, G; Panagiotou, A.D; Peryt, W; Pluta, J; Prindle, D; Puhlhofer, F; Renfordt, R; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Schmitz, N; Schuster, T; Seyboth, P; Sikler, F; Skrzypczak, E; Slodkowski, M; Stefanek, G; Stock, R; Strobele, H; Susa, T; Szuba, M; Utvic, M; Varga, D; Vassiliou, M; Veres, G I; Vesztergombi, G; Vranic, D; Wlodarczyk, Z; Wojtaszek-Szwarc, A

    2013-01-01

    New measurements by the NA49 experiment of the centrality dependence of event-by-event fluctuations of the particle yield ratios (K$^{+}$+K$^{-}$)/($\\pi^{+}+\\pi^{-}$), (p+$\\bar{\\text p}$)/($\\pi^{+}+\\pi^{-}$), and (K$^{+}$+K$^{-}$)/(p+$\\bar{\\text p}$) are presented for Pb+Pb collisions at 158$A$ GeV. The absolute values of the dynamical fluctuations of these ratios, quantified by the measure $\\sigma_{\\text{dyn}}$, increase by about a factor of two from central to semi-peripheral collisions. Multiplicity scaling scenarios are tested and found to apply for both the centrality and the previously published energy dependence of the (K$^{+}$+K$^{-}$)/($\\pi^{+}+\\pi^{-}$) and (p+$\\bar{\\text p}$)/($\\pi^{+}+\\pi^{-}$) ratio fluctuations. A description of the centrality and energy dependence of (K$^{+}$+K$^{-}$)/(p+$\\bar{\\text p}$) ratio fluctuations by a common scaling prescription is not possible since there is a sign change in the energy dependence.

  9. Baryon stopping and charged particle production from lead-lead collisions at 158 GeV per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Toy, Milton Y. [Univ. of California, Los Angeles, CA (United States)

    1999-01-01

    Net proton (proton minus antiproton) and negative charge hadron spectra (h-) from central Pb+Pb collisions at 158 GeV per nucleon at the CERN Super Proton Synchrotron were measured and compared to spectra from central collisions of the lighter S+S system. Net baryon distributions were derived from those of net protons and net lambdas. Stopping, or rapidity shift with respect to the beam, of net protons and net baryons increase with system size. The mean transverse momentum of net protons also increase with system size. The h- rapidity density scales with the number of participant nucleons for nuclear collisions, where their is independent of system size. The dependence upon particle mass and system size is consistent with larger transverse flow velocity at midrapidity for central collisions of Pb+Pb compared to that of S+S.

  10. Scale-dependence of transverse momentum correlations in Pb-Au collisions at 158A GeV/c

    CERN Document Server

    Adamová, D; Antonczyk, D; Appelshäuser, H; Belaga, V; Bielcikova, S; Braun-Munzinger, P; Busch, O; Cherlin, A; Damjanovic, S; Dietel, T; Dietrich, L; Drees, A; Dubitzky, W; Esumi, S I; Filimonov, K; Fomenko, K; Fraenkel, Zeev; Garabatos, C; Glässel, P; Holeczek, J; Kushpil, V; Maas, A; Marín, A; Milosevic, J; Milov, A; Miskowiec, D; Panebratsev, Yu A; Petchenova, O; Petracek, V; Pfeiffer, A; Ploskon, M; Radomski, S; Rak, acn J; Ravinovich, I; Rehak, P; Sako, H; Schmitz, W; Sedykh, S; Shimansky, S; Stachel, J; Sumbera, M; Tilsner, H; Tserruya, Itzhak; Tsiledakis, G; Wessels, J P; Wienold, T; Wurm, J P; Xie, W; Yurevich, S; Yurevich, V

    2008-01-01

    We present results on transverse momentum correlations of charged particle pairs produced in Pb-Au collisions at 158$A$ GeV/$c$ at the Super Proton Synchrotron. The transverse momentum correlations have been studied as a function of collision centrality, angular separation of the particle pairs, transverse momentum and charge sign. We demonstrate that the results are in agreement with previous findings in scale-independent analyses at the same beam energy. Employing the two-particle momentum correlator $$ and the cumulative $p_t$ variable $x(p_t)$, we identify, using the scale-dependent approach presented in this paper, different sources contributing to the measured correlations, such as quantum and Coulomb correlations, elliptic flow and mini-jet fragmentation.

  11. Event-by-event analysis of high multiplicity Pb(158 GeV/nucleon)-Ag/Br collisions

    Energy Technology Data Exchange (ETDEWEB)

    Cherry, M.L.; Deines-Jones, P. [Louisiana State University, Baton Rouge (United States); Dabrowska, A. [Institute of Nuclear Physics, Cracow (Poland)] [and others; KLM Collaboration

    1998-08-01

    High multiplicity nucleus-nucleus collisions are studied on an event-by- event basis. Different methods of analysis of individual collision events are presented and their ability to reveal anomalous features of the events is discussed. This study is based on full acceptance measurements of particle production in the interactions of 158 GeV/nucleon Pb with the heavy target nuclei in nuclear emulsion. No events are observed with global characteristics that differ significantly from expectations based on either Monte Carlo simulations, or the characteristics of the entire sample of events. On the other hand, it is shown that systematic analysis of particle density fluctuations in phase space domains of varying size, performed in terms of factorial moments, can be used as an effective triggering for events with large dynamical fluctuations. (author) 17 refs, 7 figs, 3 tabs

  12. No evidence of association between Catechol-O-Methyltransferase (COMT Val158Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study

    Directory of Open Access Journals (Sweden)

    O'Donovan Michael C

    2004-06-01

    Full Text Available Abstract Background Several studies have suggested an association between the functional Val158Met polymorphism in the Catechol-O-Methyltransferase (COMT gene and neurocognitive performance. Two studies showed that subjects with the low activity Met allele performed better on the Wisconsin Card Sorting Test (WCST and another study found an effect on processing speed and attention. Methods We set out to examine the association between the Val158Met polymorphism and performance on neurocognitive tasks including those tapping working memory, attention and speed, impulsiveness and response inhibition in a sample of 124 children with ADHD. Task performance for each genotypic group was compared using analysis of variance. Results There was no evidence of association with performance on any of the neurocognitive tasks. Conclusions We conclude that Val158Met COMT genotype is not associated with neurocognitive performance in our sample.

  13. A europium- and terbium-coated magnetic nanocomposite as sorbent in dispersive solid phase extraction coupled with ultra-high performance liquid chromatography for antibiotic determination in meat samples.

    Science.gov (United States)

    Castillo-García, M L; Aguilar-Caballos, M P; Gómez-Hens, A

    2015-12-18

    A new magnetic dispersive solid-phase extraction approach based on Eu- and Tb-coated magnetic nanocomposites, combined with ultra-high performance liquid chromatography with fluorometric detection, is reported for the extraction and simultaneous determination of veterinary antibiotics. The method is aimed at monitoring of potential residues of three tetracyclines, namely oxytetracycline, tetracycline, chlortetracycline and three acidic quinolones, such as oxolinic acid, nalidixic acid and flumequine, chosen as model analytes, in animal muscle samples. The nanocomposites were obtained by synthesizing magnetic nanoparticles by a co-precipitation method and their coating with terbium and europium ions. The limits of detection obtained using standard solutions were: 1.0, 1.5, 3.8, 0.25, 0.7 and 1.2ngmL(-1), which corresponds to 3.3, 5.0, 12.7, 0.8, 2.3 and 4.0μgkg(-1) for oxytetracycline, tetracycline, chlortetracycline, oxolinic acid, nalidixic acid and flumequine, respectively, in meat samples. The precision values, obtained in the presence of the sample matrix, were in the ranges 0.12-2.0% and 2.6-15.4% for retention times and areas, respectively. The selectivity of the method was checked by assaying different veterinary drugs, finding that most of them did not interfere at the same concentration levels as that of analytes. A recovery study was performed in the presence of chicken and pork muscle samples, which provided values in the range of 61.5-102.6%. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Catechol-O-methyltransferase val158met genotype determines effect of reboxetine on emotional memory in healthy male volunteers

    Science.gov (United States)

    Gibbs, Ayana A.; Bautista, Carla E.; Mowlem, Florence D.; Naudts, Kris H.; Duka, Dora T.

    2014-01-01

    Background Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the prefrontal cortex (PFC). A common polymorphism in the COMT gene (COMT val158met) has pleiotropic effects on cognitive and emotional processing. The met allele has been associated with enhanced cognitive processing but impaired emotional processing relative to the val allele. Methods We genotyped healthy, white men in relation to the COMT val158met polymorphism. They were given a single 4 mg dose of the selective noradrenaline reuptake inhibitor (NRI) reboxetine or placebo in a randomized, double-blind between-subjects model and then completed an emotional memory task 2 hours later. Results We included 75 men in the study; 41 received reboxetine and 34 received placebo. In the placebo group, met/met carriers did not demonstrate the usual memory advantage for emotional stimuli that was observed in val carriers. Reboxetine restored this emotional enhancement of memory in met/met carriers, but had no significant effect in val carriers. Limitations We studied only men, thus limiting the generalizability of our findings. We also relied on self-reported responses to screening questions to establish healthy volunteer status, and in spite of the double-blind design, participants were significantly better than chance at identifying their intervention allocation. Conclusion Emotional memory is impaired in healthy met homozygotes and selectively improved in this group by reboxetine. This has potential translational implications for the use of reboxetine, which is currently licensed as an antidepressant in several countries, and edivoxetine, a new selective NRI currently in development. PMID:24467942

  15. Modulation of the COMT Val158Met polymorphism on resting-state EEG power in postmenopausal healthy women

    Directory of Open Access Journals (Sweden)

    Silvia eSolis-Ortiz

    2015-04-01

    Full Text Available The catechol-O-methyltransferase (COMT Val158Met polymorphism impacts cortical dopamine levels and may influence cortical electrical activity in the human brain. This study investigated whether COMT genotype influences resting-state electroencephalogram (EEG power in the frontal, parietal and midline regions in healthy volunteers. EEG recordings were conducted in the resting-state in 13 postmenopausal healthy woman carriers of the Val/Val genotype and 11 with the Met/Met genotype. The resting EEG spectral absolute power in the frontal (F3, F4, F7, F8, FC3 and FC4, parietal (CP3, CP4, P3 and P4 and midline (Fz, FCz, Cz, CPz, Pz and Oz was analyzed during the eyes-open and eyes-closed conditions. The frequency bands considered were the delta, theta, alpha1, alpha2, beta1 and beta2. EEG data of the Val/Val and Met/Met genotypes, brain regions and conditions were analyzed using a general linear model analysis. In the individuals with the Met/Met genotype, delta activity was increased in the eyes-closed condition, theta activity was increased in the eyes-closed and in the eyes-open conditions, and alpha1 band, alpha2 band and beta1band activity was increased in the eyes-closed condition.A significant interaction between COMT genotypes and spectral bands was observed. Met homozygote individuals exhibited more delta, theta and beta1 activity than individuals with the Val/Val genotype. No significant interaction between COMT genotypes and the resting-state EEG regional power and conditions were observed for the three brain regions studied. Our findings indicate that the COMT Val158Met polymorphism does not directly impact resting-state EEG regional power, but instead suggest that COMT genotype can modulate resting-state EEG spectral power in postmenopausal healthy women.

  16. Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population.

    Science.gov (United States)

    Shibata, Nobuto; Nagata, Tomoyuki; Tagai, Kenji; Shinagawa, Shunichiro; Ohnuma, Tohru; Kawai, Eri; Kasanuki, Koji; Shimazaki, Hiromi; Toda, Aiko; Tagata, Yuko; Nakada, Tomoko; Nakayama, Kazuhiko; Yamada, Hisashi; Arai, Heii

    2015-09-01

    Catechol-O-methyltransferase (COMT) plays an important role in dopamine degradation, which is associated with the pathophysiology of Alzheimer's disease (AD) and alcoholism. A functional COMT polymorphism, Val158Met (rs4680 G > A), affects the onset of AD and is associated with alcohol dependence through dopamine receptor sensitivity in the prefrontal cortex. The aim of this case-control study (398 cases and 149 controls) was to investigate whether Val158Met polymorphism influences the onset of AD stratified according to alcohol consumption and apolipoprotein E (APOE) status. We also used single photon-emission computed tomography (SPECT) to analyse 26 patients with AD with the polymorphism. As a function of APOE status, the genotypic frequencies of rs4680 in patients with AD did not differ from those in controls. We detected a significant association between high alcohol consumption in patients with AD (HAC-AD group) and the polymorphism in genotypic and allelic frequencies. Logistic regression analyses demonstrated that the presence of the APOE genotype with rs4680 increased the risk for HAC-AD synergistically. Hyperperfusion in the right sub-lobar insula of patients with the G/G genotype was found compared with that of patients with the G/A genotype. SPECT studies showed a relationship between the polymorphism and compensatory reactions for dysfunctions of dopaminergic neurotransmission in AD pathophysiology. Although genetic association between the polymorphism and the onset of AD in a Japanese population were not observed, the polymorphism affected the risk for HAC-AD. Copyright © 2014 John Wiley & Sons, Ltd.

  17. Catechol-O-Methyltransferase Val158Met Polymorphism Modulates Gray Matter Volume and Functional Connectivity of the Default Mode Network

    Science.gov (United States)

    Tian, Tian; Qin, Wen; Liu, Bing; Wang, Dawei; Wang, Junping; Jiang, Tianzi; Yu, Chunshui

    2013-01-01

    The effect of catechol-O-methyltransferase (COMT) Val158Met polymorphism on brain structure and function has been previously investigated separately and regionally; this prevents us from obtaining a full picture of the effect of this gene variant. Additionally, gender difference must not be overlooked because estrogen exerts an interfering effect on COMT activity. We examined 323 young healthy Chinese Han subjects and analyzed the gray matter volume (GMV) differences between Val/Val individuals and Met carriers in a voxel-wise manner throughout the whole brain. We were interested in genotype effects and genotype × gender interactions. We then extracted these brain regions with GMV differences as seeds to compute resting-state functional connectivity (rsFC) with the rest of the brain; we also tested the genotypic differences and gender interactions in the rsFCs. Val/Val individuals showed decreased GMV in the posterior cingulate cortex (PCC) compared with Met carriers; decreased GMV in the medial superior frontal gyrus (mSFG) was found only in male Val/Val subjects. The rsFC analysis revealed that both the PCC and mSFG were functionally correlated with brain regions of the default mode network (DMN). Both of these regions showed decreased rsFCs with different parts of the frontopolar cortex of the DMN in Val/Val individuals than Met carriers. Our findings suggest that the COMT Val158Met polymorphism modulates both the structure and functional connectivity within the DMN and that gender interactions should be considered in studies of the effect of this genetic variant, especially those involving prefrontal morphology. PMID:24147141

  18. Star formation rates from [C II] 158 μm and mid-infrared emission lines for starbursts and active galactic nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Sargsyan, L.; Lebouteiller, V.; Weedman, D.; Barry, D.; Spoon, H. [Center for Radiophysics and Space Research, Cornell University, Ithaca, NY 14853 (United States); Samsonyan, A. [Byurakan Astrophysical Observatory, Byurakan 0213 (Armenia); Bernard-Salas, J. [Department of Physical Sciences, Open University, Milton Keynes MK7 6AA (United Kingdom); Houck, J., E-mail: sargsyan@isc.astro.cornell.edu, E-mail: dweedman@isc.astro.cornell.edu [Astronomy Department, Cornell University, Ithaca, NY 14853 (United States)

    2014-07-20

    A summary is presented for 130 galaxies observed with the Herschel Photodetector Array Camera and Spectrometer instrument to measure fluxes for the [C II] 158 μm emission line. Sources cover a wide range of active galactic nucleus to starburst classifications, as derived from polycyclic aromatic hydrocarbon strength measured with the Spitzer Infrared Spectrograph. Redshifts from [C II] and line to continuum strengths (equivalent width (EW) of [C II]) are given for the full sample, which includes 18 new [C II] flux measures. Calibration of L([C II)]) as a star formation rate (SFR) indicator is determined by comparing [C II] luminosities with mid-infrared [Ne II] and [Ne III] emission line luminosities; this gives the same result as determining SFR using bolometric luminosities of reradiating dust from starbursts: log SFR = log L([C II)]) – 7.0, for SFR in M{sub ☉} yr{sup –1} and L([C II]) in L{sub ☉}. We conclude that L([C II]) can be used to measure SFR in any source to a precision of ∼50%, even if total source luminosities are dominated by an active galactic nucleus (AGN) component. The line to continuum ratio at 158 μm, EW([C II]), is not significantly greater for starbursts (median EW([C II]) = 1.0 μm) compared to composites and AGNs (median EW([C II]) = 0.7 μm), showing that the far-infrared continuum at 158 μm scales with [C II] regardless of classification. This indicates that the continuum at 158 μm also arises primarily from the starburst component within any source, giving log SFR = log νL{sub ν}(158 μm) – 42.8 for SFR in M{sub ☉} yr{sup –1} and νL{sub ν}(158 μm) in erg s{sup –1}.

  19. Human papillomavirus 16L1-58L2 chimeric virus-like particles elicit durable neutralizing antibody responses against a broad-spectrum of human papillomavirus types

    OpenAIRE

    Chen, Xue; Liu, Hongyang; Wang, Zhirong; Wang, Shuo; Zhang, Ting; Hu, Meili; Qiao, Liang; Xu, Xuemei

    2017-01-01

    The neutralizing antibodies elicited by human papillomavirus (HPV) major capsid protein L1 virus-like particle (VLP)-based vaccines are largely type-specific. An HPV vaccine inducing cross-neutralizing antibodies broadly will be cost-effective and of great value. To this end, we constructed HPV16L1-58L2 chimeric VLP (cVLP) by displaying HPV58 L2 aa.16-37 on the DE surface region of HPV16 L1. We found that vaccination with the HPV16L1-58L2 cVLP formulated with alum plus monophosphoryl lipid A ...

  20. A 158 fs 5.3 nJ fiber-laser system at 1 mu m using photonic bandgap fibers for dispersion control and pulse compression

    DEFF Research Database (Denmark)

    Nielsen, C.K.; Jespersen, Kim Giessmann; Keiding, S.R.

    2006-01-01

    We demonstrate a 158 fs 5.3 nJ mode-locked laser system based on a fiber oscillator, fiber amplifier and fiber compressor. Dispersion compensation in the fiber oscillator was obtained with a solid-core photonic bandgap (SC-PBG) fiber spliced to standard fibers, and external compression is obtained...

  1. Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Lachman, H.M.; Papolos, D.F.; Veit, S. [Albert Einstein College of Medicine, Bronx, NY (United States)] [and others

    1996-09-20

    Velo-cardio-facial-syndrome (VCFS) is a common congenital disorder associated with typical facial appearance, cleft palate, cardiac defects, and learning disabilities. The majority of patients have an interstitial deletion on chromosome 22q11. In addition to physical abnormalities, a variety of psychiatric illnesses have been reported in patients with VCFS, including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder. The psychiatric manifestations of VCFS could be due to haploinsufficiency of a gene(s) within 22q11. One candidate that has been mapped to this region is catechol-O-methyltransferase (COMT). We recently identified a polymorphism in the COMT gene that leads to a valine{r_arrow}methionine substitution at amino acid 158 of the membrane-bound form of the enzyme. Homozygosity for COMT158{sup met} leads to a 3- to 4-fold reduction in enzymatic activity, compared with homozygotes for COMT158{sup met}. We now report that in a population of patients with VCFS, there is an apparent association between the low-activity allele, COMT158{sup met}, and the development of bipolar spectrum disorder, and in particular, a rapid-cycling form. 33 refs., 3 tabs.

  2. Systematics of inclusive photon production in 158 center dot A GeVPb induced reactions on Ni, Nb, and Pb targets

    NARCIS (Netherlands)

    Aggarwal, MM; Agnihotri, A; Ahammed, Z; Angelis, ALS; Antonenko, [No Value; Arefiev, [No Value; Astakhov, [No Value; Avdeitchikov, [No Value; Awes, TC; Baba, PVKS; Badyal, SK; Baldine, A; Barabach, L; Barlag, C; Bathe, S; Batiounia, B; Bernier, T; Bhalla, KB; Bhatia, VS; Blume, C; Bock, R; Bohne, EM; Borocz, Z; Bucher, D; Buijs, A; Busching, H; Carlen, L; Chalyshev, [No Value; Chattopadhyay, S; Cherbatchev, R; Chujo, T; Claussen, A; Das, AC; Decowski, MP; Djordjadze, [No Value; Donni, P; Doubovik, [No Value; Dutt, S; Majumdar, MRD; El Chenawi, K; Eliseev, S; Enosawa, K; Foka, P; Fokin, S; Frolov, [No Value; Ganti, MS; Garpman, S; Gavrishchuk, O; Geurts, FJM; Ghosh, TK; Glasow, R; Gupta, SK; Guskov, B; Gustafsson, H.A.; Gutbrod, HH; Higuchi, R; Hrivnacova, [No Value; Ippolitov, M; Kalechofsky, H; Kamermans, R; Kampert, KH; Karadjev, K; Karpio, K; Kato, S; Kees, S; Kim, H; Kolb, BW; Kosarev, [No Value; Koutcheryaev, [No Value; Krumpel, T; Kugler, A; Kulinich, P; Kurata, M; Kurita, K; Kuzmin, N; Langbein, [No Value; Lebedev, A; Lee, YY; Lohner, H; Luquin, L; Mahapatra, DP; Manko, [No Value; Martin, M; Maximov, A; Mehdiyev, R; Mgebrichvili, G; Miake, Y; Mikhalev, D; Mir, MF; Mishra, GC; Miyamoto, Y; Morrison, D; Mukhopadhyay, DS; Myalkovski, [No Value; Naef, H; Nandi, BK; Nayak, SK; Nayak, TK; Neumaier, S; Nianine, A; Nikitine, [No Value; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, P; Nystrand, J; Obenshain, FE; Oskarsson, A; Otterlund, [No Value; Pachr, M; Parfenov, A; Pavliouk, S; Peitzmann, T; Petracek, [No Value; Plasil, F; Pinanaud, W; Purschke, ML; Raeven, B; Rak, J; Raniwala, R; Raniwala, S; Ramamurthy, VS; Rao, NK; Retiere, F; Reygers, K; Roland, G; Rosselet, L; Roufanov, [No Value; Roy, C; Rubio, JM; Sako, H; Sambyal, SS; Santo, R; Sato, S; Schlagheck, H; Shabratova, G; Shah, TH; Sibiriak, [No Value; Siemiarczuk, T; Silvermyr, D; Sinha, BC; Slavine, N; Soderstrom, K; Solomey, N; Sorensen, SP; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Stuken, D; Sumbera, M; Svensson, T; Trivedi, MD; Tsvetkov, A.; Twenhofel, C; Tykarski, L; Urbahn, J; Von Eijndhoven, N; Von Nieuwenhuizen, GJ; Vinogradov, A; Viyogi, YP; Vodopianov, A; Voros, S; Wyslouch, B; Yagi, K; Yokota, Y; Young, GR

    1999-01-01

    The multiplicity of inclusive photons has been measured on an event-by-event basis for 158.A GeV Pb induced reactions on Ni, Nb, and Pb targets. The systematics of the pseudorapidity densities at midrapidity (rho(max)) and the width of the pseudorapidity distributions have been studied for varying

  3. Catechol-O-Methyltransferase "Val[superscript 158]Met" Genotype, Parenting Practices and Adolescent Alcohol Use: Testing the Differential Susceptibility Hypothesis

    Science.gov (United States)

    Laucht, Manfred; Blomeyer, Dorothea; Buchmann, Arlette F.; Treutlein, Jens; Schmidt, Martin H.; Esser, Gunter; Jennen-Steinmetz, Christine; Rietschel, Marcella; Zimmermann, Ulrich S.; Banaschewski, Tobias

    2012-01-01

    Background: Recently, first evidence has been reported for a gene-parenting interaction (G x E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase ("COMT") "Val[superscript 158]Met" polymorphism as a genetic susceptibility factor. Moreover, the current study…

  4. Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies.

    Science.gov (United States)

    Collantoni, Enrico; Solmi, Marco; Gallicchio, Davide; Santonastaso, Paolo; Meneguzzo, Paolo; Carvalho, Andrè F; Stubbs, Brendon; Clementi, Maurizio; Pinato, Claudia; Forzan, Monica; Cassina, Matteo; Fontana, Francesca; Piva, Ivana; Siani, Roberta; Salvo, Pierandrea; Tenconi, Elena; Veronese, Nicola; Correll, Christoph U; Favaro, Angela

    2017-11-01

    We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs). We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls. Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I2  = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I2  = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I2  = 0-44%). Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

  5. The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder

    Directory of Open Access Journals (Sweden)

    Bergström Jan

    2010-11-01

    Full Text Available Abstract Background Cognitive behavioral therapy (CBT represents a learning process leading to symptom relief and resulting in long-term changes in behavior. CBT for panic disorder is based on exposure and exposure-based processes can be studied in the laboratory as extinction of experimentally acquired fear responses. We have recently demonstrated that the ability to extinguish learned fear responses is associated with a functional genetic polymorphism (COMTval158met in the COMT gene and this study was aimed at transferring the experimental results on the COMTval158met polymorphism on extinction into a clinical setting. Methods We tested a possible effect of the COMTval158met polymorphism on the efficacy of CBT, in particular exposure-based treatment modules, in a sample of 69 panic disorder patients. Results We present evidence that panic patients with the COMTval158met met/met genotype may profit less from (exposure-based CBT treatment methods as compared to patients carrying at least one val-allele. No association was found with the 5-HTTLPR/rs25531 genotypes which is presented as additional material. Conclusions We were thus able to transfer findings on the effect of the COMTval158met polymorphism from an experimental extinction study obtained using healthy subjects to a clinical setting. Furthermore patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms as compared to those with the met/met genotype. Limitations of the study as well as possible clinical implications are discussed. Trial registration Clinical Trial Registry name: Internet-Versus Group-Administered Cognitive Behavior Therapy for Panic Disorder (IP2. Registration Identification number: NCT00845260, http://www.clinicaltrials.gov/ct2/show/NCT00845260

  6. Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.

    Science.gov (United States)

    Ramsay, Hugh; Kelleher, Ian; Flannery, Padraig; Clarke, Mary C; Lynch, Fionnuala; Harley, Michelle; Connor, Dearbhla; Fitzpatrick, Carol; Morris, Derek W; Cannon, Mary

    2013-01-01

    Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with psychotic experiences or interacted with childhood trauma in predicting psychotic experiences. Psychiatric interviews and genotyping for COMT-Val158Met and BDNF-Val66Met were carried out on two population-based samples of 237 individuals aged 11-15 years. Logistic regression was used to examine for main effects by genotype and childhood trauma, controlling for important covariates. This was then compared to a model with a term for interaction between genotype and childhood trauma. Where a possible interaction was detected, this was further explored in stratified analyses. While childhood trauma showed a borderline association with psychotic experiences, COMT-Val158Met and BDNF-Val66Met genotypes were not directly associated with psychotic experiences in the population. Testing for gene x environment interaction was borderline significant in the case of COMT-Val158Met with individuals with the COMT-Val158Met Val-Val genotype, who had been exposed to childhood trauma borderline significantly more likely to report psychotic experiences than those with Val-Met or Met-Met genotypes. There was no similar interaction by BDNF-Val66Met genotype. The COMT-Val158Met Val-Val genotype may be a genetic moderator of risk for psychotic experiences in individuals exposed to childhood traumatic experiences.

  7. Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.

    Directory of Open Access Journals (Sweden)

    Hugh Ramsay

    Full Text Available OBJECTIVE: Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with psychotic experiences or interacted with childhood trauma in predicting psychotic experiences. METHOD: Psychiatric interviews and genotyping for COMT-Val158Met and BDNF-Val66Met were carried out on two population-based samples of 237 individuals aged 11-15 years. Logistic regression was used to examine for main effects by genotype and childhood trauma, controlling for important covariates. This was then compared to a model with a term for interaction between genotype and childhood trauma. Where a possible interaction was detected, this was further explored in stratified analyses. RESULTS: While childhood trauma showed a borderline association with psychotic experiences, COMT-Val158Met and BDNF-Val66Met genotypes were not directly associated with psychotic experiences in the population. Testing for gene x environment interaction was borderline significant in the case of COMT-Val158Met with individuals with the COMT-Val158Met Val-Val genotype, who had been exposed to childhood trauma borderline significantly more likely to report psychotic experiences than those with Val-Met or Met-Met genotypes. There was no similar interaction by BDNF-Val66Met genotype. CONCLUSION: The COMT-Val158Met Val-Val genotype may be a genetic moderator of risk for psychotic experiences in individuals exposed to childhood traumatic experiences.

  8. The val158met polymorphism of human catechol-O-methyltransferase (COMT affects anterior cingulate cortex activation in response to painful laser stimulation

    Directory of Open Access Journals (Sweden)

    Musso Francesco

    2010-05-01

    Full Text Available Abstract Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography. The functional val158met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI, PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT val158met polymorphism on the blood oxygen level-dependent (BOLD response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC, foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT val158met polymorphism on cerebral pain processing.

  9. $\\phi$ production in Pb-Pb collisions at 158 GeV/c per nucleon incident momentum

    CERN Document Server

    Alessandro, B; Arnaldi, R; Astruc, J; Atayan, M; Baglin, C; Baldit, A; Beolè, S; Boldea, V; Bordalo, P; Borges, G; Bussière, A; Capelli, L; Caponi, V; Castanier, C; Castor, J I; Chaurand, B; Chevrot, I; Cheynis, B; Chiavassa, E; Cicalò, C; Claudino, T; Comets, M P; Constans, N; Constantinescu, S; Cortese, P; Cruz, J; De Falco, A; De Marco, N; Dellacasa, G; Devaux, A; Dita, S; Drapier, O; Ducroux, L; Espagnon, B; Fargeix, J; Force, P; Gallio, M; Gavrilov, Yu K; Gerschel, C; Giubellino, P; Golubeva, M B; Gonin, M; Grigorian, A A; Grigoryanm, S; Grossiord, J Y; Guber, F F; Guichard, A; Gulkanian, H R; Hakobyan, R S; Idzik, M; Jouan, D; Karavitcheva, T L; Kluberg, L; Kurepin, A B; Le Bornec, Y; Lourenço, C; Macciotta, P; MacCormick, M; Marzari-Chiesa, A; Masera, M; Masoni, A; Monteno, M; Musso, A; Petiau, P; Piccotti, A; Pizzi, J R; Da Silva, W; Prino, F; Puddu, G; Quintans, C; Ramello, L; Ramos, S; Rato-Mendes, P; Riccati, L; Romana, A; Santos, H; Saturnini, P; Scalas, E; Scomparin, E; Serci, S; Shahoyan, R; Sigaudo, F; Silva, S; Sitta, M; Sonderegger, P; Tarrago, X; Topilskaya, N S; Usai, G L; Vercellin, Ermanno; Villatte, L; Willis, N

    2003-01-01

    The production of vector mesons phi , rho and omega has been measured in Pb-Pb collisions at 158 GeV/c per nucleon incident momentum at the CERN/SPS. The muon spectrometer of experiment NA50 detects phi , rho and omega mesons via their mu /sup +/ mu /sup -/ decay channel in the collision center of mass rapidity range 0

  10. [Population characterization of Balantidium coli from pigs using ITS1-5.8S rRNA-ITS2 sequence].

    Science.gov (United States)

    Wang, Tianqi; Dou, Gang; Yan, Wenchao; Zhang, Longxian; Han, Lifang; Ding, Ke; Jia, Chuanchuan; Zhang, Meng; Yu, Dujuan

    2011-06-01

    To determine the species and genotypes of Balantidium isolated from pigs in Henan province, China. Scatoscopy and the modified DMEM media were used to isolate trophozoites of Balantidium from pig feces. The ITS1-5.8S rRNA-ITS2-based molecular marker method, Acridine orange staining ( AO) and microscopic observation were used to determine the population characteristics among different isolates of B. coli from various pigs farms. We isolated 15 isolates from the pigs at diagnosis in the Animal Hospital of Henan University of Science and Technology from the pig farms of the 8 counties or cities of the west of Henan province in total, and all of them belong to the same species B. coli. MJ-2 and SX-1 isolates were genotype A of B. coli, and the remaining 13 isolates were genotype B. Trophozoites of MJ-2 and SX-1 were bigger, moved more slowly and lower density in feces and in vitro culture than other 13 isolates, while structures of their nuclei were not different. Both genotype A and B of B. coli are present in the pig farms of the west of Henan province, China, and genotype B is the determinant population in pigs farms. These findings could provide an important implication for the effective control of balantidiosis of human and other hosts.

  11. Disparity in rainfall trend and patterns among different regions: analysis of 158 years' time series of rainfall dataset across India

    Science.gov (United States)

    Saha, Saurav; Chakraborty, Debasish; Paul, Ranjit Kumar; Samanta, Sandipan; Singh, S. B.

    2017-10-01

    Rainfall anomaly during crop-growing season can have large impact on the agricultural output of a country, especially like India, where two-thirds of the crop land is rain-fed. In such situation, decreased agricultural production not only challenges food security of the country but directly and immediately hits the livelihood of its farming community. In a vast country like India, rainfall or its anomalies hardly follow a specific pattern, rather it is having high variability in spatial domain. This study focused on the trends of national and regional rainfall anomalies (wetness/dryness) along with their interrelationship using time series data of past 158 years. The significant reducing wetness trend (p tests indicate that major abrupt changes occurred between early to mid-twentieth century having regional variations. The regional interrelationship was studied using principal component, hierarchical clustering, and pair-wise difference test, which clearly indicated a significantly different pattern in rainfall anomalies for north east India (p = 0.022), north central India (p = 0.022), and north mountainous India (p = 0.011) from that of the all India. Result of this study affirmed high spatial variability in rainfall anomaly and most importantly established the unalike pattern in trends of regional rainfall vis-à-vis national level, ushering towards paradigm shift in rainfall forecast from country scale to regional scale for pragmatic planning.

  12. Emission of forward neutrons by 158A GeV indium nuclei in collisions with Al, Cu, Sn and Pb

    Energy Technology Data Exchange (ETDEWEB)

    Karpechev, E.V. [Institute for Nuclear Research, Russian Academy of Sciences, 117312 Moscow (Russian Federation); Pshenichnov, I.A., E-mail: pshenich@inr.ru [Institute for Nuclear Research, Russian Academy of Sciences, 117312 Moscow (Russian Federation); Karavicheva, T.L.; Kurepin, A.B.; Golubeva, M.B.; Guber, F.F.; Maevskaya, A.I.; Reshetin, A.I.; Tiflov, V.V.; Topilskaya, N.S. [Institute for Nuclear Research, Russian Academy of Sciences, 117312 Moscow (Russian Federation); Cortese, P.; Dellacasa, G. [Dipartimento di Scienze e Tecnologie Avanzate and INFN, Corso Borsalino 54, 15100 Alessandria (Italy); Arnaldi, R.; De Marco, N.; Ferretti, A.; Gallio, M.; Musso, A.; Oppedisano, C.; Piccotti, A.; Scomparin, E. [Università di Torino and INFN, Via Pietro Giuria 1, 10125 Torino (Italy); and others

    2014-01-15

    The cross sections of forward emission of one, two and three neutrons by 158A GeV {sup 115}In nuclei in collisions with Al, Cu, Sn and Pb targets are reported. The measurements were performed in the framework of the ALICE–LUMI experiment at the SPS facility at CERN. Various corrections accounting for the absorption of beam nuclei and produced neutrons in target material and surrounding air were introduced. The corrected cross section data are compared with the predictions of the RELDIS model for electromagnetic fragmentation of {sup 115}In in ultraperipheral collisions, as well as with the results of the abrasion–ablation model for neutron emission in hadronic interactions. The measured neutron emission cross sections well agree with the RELDIS results, with the exception of In–Al collisions where the measured cross sections are larger compared to RELDIS. This is attributed to a relatively large contribution of hadronic fragmentation of In on Al target with respect to electromagnetic fragmentation, in contrast to similar measurements performed earlier with 30A GeV {sup 208}Pb colliding with Al.

  13. Effects of FCGRIIIa-158V/F polymorphism on antibody-dependent cellular cytotoxicity activity of adalimumab.

    Science.gov (United States)

    Kimura, Koji; Kobayashi, Daigo; Hatoyama, Saori; Yamamoto, Mizuki; Takayanagi, Risa; Yamada, Yasuhiko

    2017-09-15

    The associations between the efficacy of IgG reagents and the FCGRIIIa-158V/F polymorphism (rs396991) have been investigated. Although the genotype frequencies in healthy Japanese have been reported, those have varied, as one study reported that the proportions of V/V, V/F, and F/F were 59.1%, 38.6%, and 2.3%, respectively, while another study found that they were 4%, 44%, and 52%, respectively. However, there are no known investigations of the association between the antibody-dependent cellular cytotoxicity (ADCC) activity of adalimumab (ADA), an IgG reagent, in combination with FcγRIIIa and the polymorphism. In this study, we analyzed healthy Japanese to clarify genotype frequency using a direct sequence method. In addition, we examined the association between the ADA-mediated ADCC activity and the polymorphism. Our results showed that the frequencies of the V/V, V/F, and F/F genotypes in healthy Japanese were 9.2%, 39.8%, and 51.0%, respectively. The average activity of ADA-mediated ADCC was 25.0%, 19.0%, and 13.3% in the V/V, V/F, and F/F genotypes, respectively. Then, the ADCC activity of V/V was significantly higher than that of F/F (p F polymorphism. © 2017 APMIS. Published by John Wiley & Sons Ltd.

  14. Energy dependence of multiplicity fluctuations in heavy ion collisions at 20A to 158A GeV

    CERN Document Server

    Alt, C.; Baatar, B.; Barna, D.; Bartke, J.; Betev, L.; Bialkowska, Helena; Blume, Christoph; Boimska, B.; Botje, Michiel; Bracinik, J.; Bramm, R.; Buncic, P.; Cerny, V.; Christakoglou, P.; Chung, P.; Chvala, O.; Cramer, J.G.; Csato, P.; Dinkelaker, P.; Eckardt, V.; Flierl, D.; Fodor, Zoltan; Foka, P.; Friese, Volker; Gal, J.; Gazdzicki, Marek; Genchev, V.; Georgopoulos, G.; Gladysz, E.; Grebieszkow, K.; Hegyi, S.; Hohne, C.; Kadija, K.; Karev, A.; Kikola, D.; Kliemant, M.; Kniege, S.; Kolesnikov, V.I.; Kornas, E.; Korus, R.; Kowalski, M.; Kraus, I.; Kreps, M.; Laszlo, A.; Lacey, Roy A.; van Leeuwen, M.; Levai, P.; Litov, Leandar; Makariev, M.; Malakhov, A.I.; Mateev, M.; Melkumov, G.L.; Mischke, A.; Mitrovski, M.; Molnar, J.; Mrowczynski, St.; Nicolic, V.; Palla, G.; Panagiotou, Apostolos D.; Panayotov, D.; Peryt, W.; Pikna, M.; Pluta, J.; Prindle, D.; Puhlhofer, F.; Renfordt, R.; Roland, C.; Roland, Gunther; Rybczynski, M.; Rybicki, A.; Sandoval, Andres; Schmitz, Norbert; Schuster, T.; Seyboth, P.; Sikler, F.; Sitar, B.; Skrzypczak, E.; Slodkowski, M.; Stefanek, Grzegorz; Stock, R.; Strabel, C.; Strobele, H.; Susa, T.; Szentpetery, I.; Sziklai, J.; Szuba, M.; Szymanski, P.; Trubnikov, V.; Utvic, M.; Varga, D.; Vassiliou, M.; Veres, G.I.; Vesztergombi, G.; Vranic, D.; Wetzler, A.; Wlodarczyk, Z.; Wojtaszek, A.; Yoo, I.K.

    2008-01-01

    Multiplicity fluctuations of positively, negatively and all charged hadrons in the forward hemisphere were studied in central Pb+Pb collisions at 20A, 30A, 40A, 80A and 158A GeV. The multiplicity distributions and their scaled variances $\\omega$ are presented in dependence of collision energy as well as of rapidity and transverse momentum. The distributions have bell-like shape and their scaled variances are in the range from 0.8 to 1.2 without any significant structure in their energy dependence. No indication of the critical point fluctuations are observed. The string-hadronic model UrQMD significantly overpredicts the mean, but approximately reproduces the scaled variance of the multiplicity distributions. The predictions of the statistical hadron-resonance gas model obtained within the grand-canonical and canonical ensembles disagree with the measured scaled variances. The narrower than Poissonian multiplicity fluctuations measured in numerous cases may be explained by the impact of conservation laws on f...

  15. Detailed analysis of two particle correlations in central Pb-Au collisions at 158 GeV per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Antonczyk, D.

    2006-07-01

    This thesis presents a two-particle correlation analysis of the fully calibrated high statistics CERES Pb+Au collision data at the top SPS energy, with the emphasis on the pion-proton correlations and the event-plane dependence of the correlation radii. CERES is a dilepton spectrometer at CERN SPS. After the upgrade, which improved the momentum resolution and extended the detector capabilities to hadrons, CERES collected 30 million Pb+Au events at 158 AGeV in the year 2000. A previous Hanbury-Brown-Twiss (HBT) analysis of pion pairs in a subset of these data, together with the results obtained at other beam energies, lead to a new freeze-out criterion [AAA+03]. In this work, the detailed transverse momentum and event-plane dependence of the pion correlation radii, as well as the pion-proton correlations, are discussed in the framework of the blast wave model of the expanding fireball. Furthermore, development of an electron drift velocity gas monitor for the ALICE TPC sub-detector is presented. The new method of the gas composition monitoring is based on the simultaneous measurement of the electron drift velocity and the gas gain and is sensitive to even small variations of the gas mixture composition. Several modifications of the apparatus were performed resulting in the final drift velocity resolution of 0.3 permille. (orig.)

  16. Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation.

    Science.gov (United States)

    Liu, Jia; Saito, Kan; Maruya, Yuriko; Nakamura, Takashi; Yamada, Aya; Fukumoto, Emiko; Ishikawa, Momoko; Iwamoto, Tsutomu; Miyazaki, Kanako; Yoshizaki, Keigo; Ge, Lihong; Fukumoto, Satoshi

    2016-03-31

    Bone morphogenetic proteins (BMPs) regulate hard tissue formation, including bone and tooth. Growth differentiation factor 5 (GDF5), a known BMP, is expressed in cartilage and regulates chondrogenesis, and mutations have been shown to cause osteoarthritis. Notably, GDF5 is also expressed in periodontal ligament tissue; however, its role during tooth development is unclear. Here, we used cell culture and in vivo analyses to determine the role of GDF5 during tooth development. GDF5 and its associated BMP receptors are expressed at the protein and mRNA levels during postnatal tooth development, particularly at a stage associated with enamel formation. Furthermore, whereas BMP2 was observed to induce evidently the differentiation of enamel-forming ameloblasts, excess GDF5 induce mildly this differentiation. A mouse model harbouring a mutation in GDF5 (W408R) showed enhanced enamel formation in both the incisors and molars, but not in the tooth roots. Overexpression of the W408R GDF5 mutant protein was shown to induce BMP2-mediated mRNA expression of enamel matrix proteins and downstream phosphorylation of Smad1/5/8. These results suggest that mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-signalling.

  17. One-, Two- and Three-Particle Distributions from 158 A GeV/c Central Pb+Pb Collisions

    CERN Document Server

    Aggarwal, M M; Antonenko, V G; Arefev, V; Astakhov, V A; Avdeichikov, V; Awes, T C; Baba, P V K S; Badyal, S K; Bathe, S; Batyunya, B; Bernier, T; Bhalla, K B; Bhatia, V S; Blume, C; Bucher, D; Büsching, H; Carlén, L; Chattopadhyay, S; Decowski, M P; Delagrange, H; Dönni, P; Dutta-Majumdar, M R; El-Chenawi, K F; Enosawa, K; Fokin, S; Frolov, V; Ganti, M S; Garpman, S; Gavrishchuk, O P; Geurts, F J M; Ghosh, T K; Glasow, R; Guskov, B; Gustafsson, Hans Åke; Gutbrod, H H; Hrivnacova, I; Ippolitov, M S; Kalechofsky, H; Kamermans, R; Karadzhev, K; Karpio, K; Kolb, B W; Kosarev, I; Kucheryaev, I; Kugler, A; Kulinich, P; Kurata, M; Lebedev, A; Löhner, H; Mahapatra, D P; Man'ko, V; Martin, M; Martínez, G; Maksimov, A; Miake, Y; Mishra, G C; Mohanty, B; Mora, M J; Morrison, D; Mukhanova, T; Mukhopadhyay, D S; Naef, H; Nandi, B K; Nayak, S K; Nayak, T K; Nyanin, A; Nikitin, V; Nikolaev, S; Nilsson, P; Nishimura, S; Nomokonov, V P; Nystrand, J; Oskarsson, A; Otterlund, I; Peitzmann, T; Peressounko, D Yu; Petracek, V; Plasil, F; Purschke, M L; Rak, J; Raniwala, R; Raniwala, S; Rao, N K; Reygers, K; Roland, G; Rosselet, L; Rufanov, I; Rubio, J M; Sambyal, S S; Santo, R; Sato, S; Schlagheck, H; Schmidt, H R; Schutz, Y; Shabratova, G; Shah, T H; Sibiryak, Yu; Siemiarczuk, T; Silvermyr, D; Sinha, B C; Slavin, N V; Söderström, K; Sood, G; Sørensen, S P; Stankus, P; Stefanek, G; Steinberg, P; Stenlund, E; Sumbera, M; Svensson, T; Tsvetkov, A; Tykarski, L; Van den Pijll, E C; van Eijndhoven, N; van Nieuwenhuizen, G J; Vinogradov, A; Viyogi, Y P; Vodopyanov, A S; Vörös, S; Wyslouch, B; Young, G R

    2003-01-01

    Several hadronic observables have been studied in central 158 A GeV Pb+Pb collisions using data measured by the WA98 experiment at CERN: single negative pion and kaon production, as well as two- and three-pion interferometry. The Wiedemann-Heinz hydrodynamical model has been fitted to the pion spectrum, giving an estimate of the temperature and transverse flow velocity. Bose-Einstein correlations between two identified negative pions have been analysed as a function of kT, using two different parameterizations. The results indicate that the source does not have a strictly boost invariant expansion or spend time in a long-lived intermediate phase. A comparison between data and a hydrodynamical based simulation shows very good agreement for the radii parameters as a function of kT. The pion phase-space density at freeze-out has been measured and agrees well with the Tomasik-Heinz model. A large pion chemical potential close to the condensation limit of the pion mass seems to be excluded. The three-pion Bose-Ein...

  18. COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence

    Directory of Open Access Journals (Sweden)

    C. A. Bousman

    2010-01-01

    Full Text Available Catechol-O-methyltransferease (COMT metabolizes prefrontal cortex dopamine (DA, a neurotransmitter involved in executive behavior; the Val158Met genotype has been linked to executive dysfunction, which might increase sexual risk behaviors favoring HIV transmission. Main and interaction effects of COMT genotype and executive functioning on sexual risk behavior were examined. 192 sexually active nonmonogamous men completed a sexual behavior questionnaire, executive functioning tests, and were genotyped using blood-derived DNA. Main effects for executive dysfunction but not COMT on number of sexual partners were observed. A COMT x executive dysfunction interaction was found for number of sexual partners and insertive anal sex, significant for carriers of the Met/Met and to a lesser extent Val/Met genotypes but not Val/Val carriers. In the context of HIV and methamphetamine dependence, dopaminergic overactivity in prefrontal cortex conferred by the Met/Met genotype appears to result in a liability for executive dysfunction and potentially associated risky sexual behavior.

  19. Emission of forward neutrons by 158A GeV indium nuclei in collisions with Al, Cu, Sn and Pb

    CERN Document Server

    Karpechev, E V; Karavicheva, T L; Kurepin, A B; Golubeva, M B; Guber, F F; Maevskaia, A I; Reshetin, A I; Tiflov, V V; Topilskaya, N S; Cortese, P; Dellacasa, G; Arnaldi, R; DeMarco, N; Ferretti, A; Gallio, M; Musso, A; Oppedisano, C; Piccotti, A; Scomparin, E; Vercellin, E; Cicalo, C; Puddu, G; Siddi, E; Szymanski, P; Efthymiopoulos, I

    2014-01-01

    The cross sections of forward emission of one, two and three neutrons by 158A GeV 115In nuclei in collisions with Al, Cu, Sn and Pb targets are reported. The measurements were performed in the framework of the ALICE-LUMI experiment at the SPS facility at CERN. Various corrections accounting for the absorption of beam nuclei and produced neutrons in target material and surrounding air were introduced. The corrected cross section data are compared with the predictions of the RELDIS model for electromagnetic fragmentation of 115In in ultraperipheral collisions, as well as with the results of the abrasion-ablation model for neutron emission in hadronic interactions. The measured neutron emission cross sections well agree with the RELDIS results, with the exception of In-Al collisions where the measured cross sections are larger compared to RELDIS. This is attributed to a relatively large contribution of hadronic fragmentation of In on Al target with respect to electromagnetic fragmentation, on the contrary to sim...

  20. Structure of dehaloperoxidase B at 1.58 Å resolution and structural characterization of the AB dimer from Amphitrite ornata

    Energy Technology Data Exchange (ETDEWEB)

    de Serrano, Vesna; D; Antonio, Jennifer; Franzen, Stefan; Ghiladi, Reza A. (NCSU)

    2012-04-18

    As members of the globin superfamily, dehaloperoxidase (DHP) isoenzymes A and B from the marine annelid Amphitrite ornata possess hemoglobin function, but they also exhibit a biologically relevant peroxidase activity that is capable of converting 2,4,6-trihalophenols to the corresponding 2,6-dihaloquinones in the presence of hydrogen peroxide. Here, a comprehensive structural study of recombinant DHP B, both by itself and cocrystallized with isoenzyme A, using X-ray diffraction is presented. The structure of DHP B refined to 1.58 {angstrom} resolution exhibits the same distal histidine (His55) conformational flexibility as that observed in isoenzyme A, as well as additional changes to the distal and proximal hydrogen-bonding networks. Furthermore, preliminary characterization of the DHP AB heterodimer is presented, which exhibits differences in the AB interface that are not observed in the A-only or B-only homodimers. These structural investigations of DHP B provide insights that may relate to the mechanistic details of the H{sub 2}O{sub 2}-dependent oxidative dehalogenation reaction catalyzed by dehaloperoxidase, present a clearer description of the function of specific residues in DHP at the molecular level and lead to a better understanding of the paradigms of globin structure-function relationships.

  1. Conformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158

    Science.gov (United States)

    Boer, D. Roeland; Ruiz-Masó, José Angel; Rueda, Manuel; Petoukhov, Maxim V.; Machón, Cristina; Svergun, Dmitri I.; Orozco, Modesto; Del Solar, Gloria; Coll, Miquel

    2016-02-01

    DNA replication initiation is a vital and tightly regulated step in all replicons and requires an initiator factor that specifically recognizes the DNA replication origin and starts replication. RepB from the promiscuous streptococcal plasmid pMV158 is a hexameric ring protein evolutionary related to viral initiators. Here we explore the conformational plasticity of the RepB hexamer by i) SAXS, ii) sedimentation experiments, iii) molecular simulations and iv) X-ray crystallography. Combining these techniques, we derive an estimate of the conformational ensemble in solution showing that the C-terminal oligomerisation domains of the protein form a rigid cylindrical scaffold to which the N-terminal DNA-binding/catalytic domains are attached as highly flexible appendages, featuring multiple orientations. In addition, we show that the hinge region connecting both domains plays a pivotal role in the observed plasticity. Sequence comparisons and a literature survey show that this hinge region could exists in other initiators, suggesting that it is a common, crucial structural element for DNA binding and manipulation.

  2. Differential influence of 5-HTTLPR - polymorphism and COMT Val158Met - polymorphism on emotion perception and regulation in healthy women.

    Science.gov (United States)

    Weiss, Elisabeth M; Freudenthaler, H Harald; Fink, Andreas; Reiser, Eva M; Niederstätter, Harald; Nagl, Simone; Parson, Walther; Papousek, Ilona

    2014-05-01

    Converging evidence indicates that a considerable amount of variance in self-estimated emotional competency can be directly attributed to genetic factors. The current study examined the associations between the polymorphisms of the Catechol-O-methyltransferase (COMT Met158Val) and the serotonin transporter (5-HTTLPR) and specific measures of the self-estimated effectiveness of an individual's emotion perception and regulation. Emotional competence was measured in a large sample of 289 healthy women by using the Self-report Emotional Ability Scale (SEAS), which includes two subscales for the assessment of emotion perception and regulation in the intra-personal domain and two subscales for the assessment of emotion perception and regulation in the inter-personal domain. Participants' reports of effective emotion regulation in everyday life were associated with the COMT Met-allele, with women homozygous for the Val-allele scoring lowest on this scale. Self-estimated effectiveness of emotion perception of the individual's own emotions was related to the 5-HTTLPR. Both homozygous groups (s/s and l/l) rated their intra-personal emotion perception less effective than participants in the heterozygous s/l group. Taken together, the results indicate that genetic variants of the COMT and 5HTTLPR genes are differentially associated with specific measures of the self-estimated effectiveness of an individual's emotion perception and regulation in the intra-personal domain.

  3. Multistrange Hyperon Production in Pb+Pb collisions at 30, 40, 80 and 158 A$\\cdot$GeV

    CERN Document Server

    Mitrovski, Michael; Anticic, T; Baatar, B; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Fischer, H G; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Retyk, W; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wenig, S; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J; Mitrovski, Michael

    2004-01-01

    A non-monotonic energy dependence of the $K^{+} / \\pi^{+}$ ratio with a sharp maximum close to 30 A$\\cdot$GeV is observed in central Pb+Pb collisions. Within a statistical model of the early stage, this is interpreted as a sign of the phase transition to a QGP, which causes a sharp change in the energy dependence of the strangeness to entropy ratio. This observation naturally motivates us to study the production of multistrange hyperons ($\\Xi$, $\\Omega$) as a function of the beam energy. Furthermore it was suggested that the kinematic freeze-out of $\\Omega$ takes place directly at QGP hadronization. If this is indeed the case, the transverse momentum spectra of the $\\Omega$ directly reflect the transverse expansion velocity of a hadronizing QGP. In this report we show preliminary NA49 results on $\\Omega^{-}$ and $\\bar{\\Omega}^{+}$ production in central Pb+Pb collisions at 40 and 158 A$\\cdot$GeV and compare them to measurements of $\\Xi^{-}$ and $\\bar{\\Xi}^{+}$ production in central Pb+Pb collisions at 30, 40, ...

  4. Differential Recognition of Influenza A Viruses by M158-66 Epitope-Specific CD8+ T Cells Is Determined by Extraepitopic Amino Acid Residues.

    Science.gov (United States)

    van de Sandt, Carolien E; Kreijtz, Joost H C M; Geelhoed-Mieras, Martina M; Nieuwkoop, Nella J; Spronken, Monique I; van de Vijver, David A M C; Fouchier, Ron A M; Osterhaus, Albert D M E; Rimmelzwaan, Guus F

    2015-11-04

    Natural influenza A virus infections elicit both virus-specific antibody and CD4(+) and CD8(+) T cell responses. Influenza A virus-specific CD8(+) cytotoxic T lymphocytes (CTLs) contribute to clearance of influenza virus infections. Viral CTL epitopes can display variation, allowing influenza A viruses to evade recognition by epitope-specific CTLs. Due to functional constraints, some epitopes, like the immunodominant HLA-A*0201-restricted matrix protein 1 (M158-66) epitope, are highly conserved between influenza A viruses regardless of their subtype or host species of origin. We hypothesized that human influenza A viruses evade recognition of this epitope by impairing antigen processing and presentation by extraepitopic amino acid substitutions. Activation of specific T cells was used as an indication of antigen presentation. Here, we show that the M158-66 epitope in the M1 protein derived from human influenza A virus was poorly recognized compared to the M1 protein derived from avian influenza A virus. Furthermore, we demonstrate that naturally occurring variations at extraepitopic amino acid residues affect CD8(+) T cell recognition of the M158-66 epitope. These data indicate that human influenza A viruses can impair recognition by M158-66-specific CTLs while retaining the conserved amino acid sequence of the epitope, which may represent a yet-unknown immune evasion strategy for influenza A viruses. This difference in recognition may have implications for the viral replication kinetics in HLA-A*0201 individuals and spread of influenza A viruses in the human population. The findings may aid the rational design of universal influenza vaccines that aim at the induction of cross-reactive virus-specific CTL responses. Influenza viruses are an important cause of acute respiratory tract infections. Natural influenza A virus infections elicit both humoral and cellular immunity. CD8(+) cytotoxic T lymphocytes (CTLs) are directed predominantly against conserved internal

  5. Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis.

    Science.gov (United States)

    Huang, Eric; Zai, Clement C; Lisoway, Amanda; Maciukiewicz, Malgorzata; Felsky, Daniel; Tiwari, Arun K; Bishop, Jeffrey R; Ikeda, Masashi; Molero, Patricio; Ortuno, Felipe; Porcelli, Stefano; Samochowiec, Jerzy; Mierzejewski, Pawel; Gao, Shugui; Crespo-Facorro, Benedicto; Pelayo-Terán, José M; Kaur, Harpreet; Kukreti, Ritushree; Meltzer, Herbert Y; Lieberman, Jeffrey A; Potkin, Steven G; Müller, Daniel J; Kennedy, James L

    2016-05-01

    The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with significant differences in enzymatic activity and consequently dopamine concentrations in the prefrontal cortex. Multiple studies have analyzed the COMT Val158Met variant in relation to antipsychotic response. Here, we conducted a meta-analysis examining the relationship between COMT Val158Met and antipsychotic response. Searches using PubMed, Web of Science, and PsycInfo databases (03/01/2015) yielded 23 studies investigating COMT Val158Met variation and antipsychotic response in schizophrenia and schizo-affective disorder. Responders/nonresponders were defined using each study's original criteria. If no binary response definition was used, authors were asked to define response according to at least 30% Positive and Negative Syndrome Scale score reduction (or equivalent in other scales). Analysis was conducted under a fixed-effects model. Ten studies met inclusion criteria for the meta-analysis. Five additional antipsychotic-treated samples were analyzed for Val158Met and response and included in the meta-analysis (ntotal=1416). Met/Met individuals were significantly more likely to respond than Val-carriers (P=.039, ORMet/Met=1.37, 95% CI: 1.02-1.85). Met/Met patients also experienced significantly greater improvement in positive symptoms relative to Val-carriers (P=.030, SMD=0.24, 95% CI: 0.024-0.46). Posthoc analyses on patients treated with atypical antipsychotics (n=1207) showed that Met/Met patients were significantly more likely to respond relative to Val-carriers (P=.0098, ORMet/Met=1.54, 95% CI: 1.11-2.14), while no difference was observed for typical-antipsychotic-treated patients (n=155) (P=.65). Our findings suggest that the COMT Val158Met polymorphism is associated with response to antipsychotics in schizophrenia and schizo-affective disorder patients. This effect may be more pronounced for

  6. Association between the COMT Val158Met polymorphism and risk of cancer: evidence from 99 case–control studies

    Directory of Open Access Journals (Sweden)

    Zhou Q

    2015-10-01

    Full Text Available Quan Zhou, Yan Wang, Aihua Chen, Yaling Tao, Huamei Song, Wei Li, Jing Tao, Manzhen ZuoDepartment of Gynecology and Obstetrics, The People’s Hospital of Three Gorges University, The First People’s Hospital of Yichang, Yichang, People’s Republic of ChinaAbstract: Catechol-O-methyltransferase (COMT plays a central role in DNA repair and estrogen-induced carcinogenesis. Many recent epidemiologic studies have investigated the association between the COMT Val158Met polymorphism and cancer risk, but the results are inconclusive. In this study, we performed a meta-analysis to investigate the association between cancer susceptibility and COMT Val158Met in different genetic models. Overall, no significant associations were found between COMT Val158Met polymorphism and cancer risk (homozygote model: odds ratio [OR] =1.05, 95% confidence interval [CI] = [0.98, 1.13]; heterozygote model: OR =1.01, 95% CI = [0.98, 1.04]; dominant model: OR =1.02, 95% CI [0.97, 1.06], and recessive model: OR =1.03, 95% CI [0.97, 1.09]. In the subgroup ­analysis of cancer type, COMT Val158Met was significantly associated with increased risks of ­bladder cancer in recessive model, and esophageal cancer in homozygote model, heterozygote model, and dominant model. Subgroup analyses based on ethnicities, COMT Val158Met was significantly associated with increased risk of cancer in homozygote and recessive model among Asians. In addition, homozygote, recessive, and dominant models were significantly associated with increased cancer risk in the subgroup of allele-specific polymerase chain reaction genotyping. Significant associations were not observed when data were stratified by the source of the controls. In summary, this meta-analysis suggested that COMT Val158Met polymorphism might not be a risk factor for overall cancer risk, but it might be involved in cancer development at least in some ethnic groups (Asian or some specific cancer types (bladder and esophageal cell

  7. Differential effects of the catechol-O-methyltransferase Val158Met genotype on the cognitive function of schizophrenia patients and healthy Japanese individuals.

    Directory of Open Access Journals (Sweden)

    Shoko Tsuchimine

    Full Text Available BACKGROUND: The functional polymorphism Val158Met in the catechol-O-methyltransferase (COMT gene has been associated with differences in prefrontal cognitive functions in patients with schizophrenia and healthy individuals. Several studies have indicated that the Met allele is associated with better performance on measures of cognitive function. We investigated whether the COMT Val158Met genotype was associated with cognitive function in 149 healthy controls and 118 patients with schizophrenia. METHODS: Cognitive function, including verbal memory, working memory, motor speed, attention, executive function and verbal fluency, was assessed by the Brief Assessment of Cognition in Schizophrenia (BACS-J. We employed a one-way analysis of variance (ANOVA and a multiple regression analysis to determine the associations between the COMT Val158Met genotype and the BACS-J measurements. RESULTS: The one-way ANOVA revealed a significant difference in the scores on the Tower of London, a measure of executive function, between the different Val158Met genotypes in the healthy controls (p = 0.023, and a post-hoc analysis showed significant differences between the scores on the Tower of London in the val/val genotype group (18.6 ± 2.4 compared to the other two groups (17.6 ± 2.7 for val/met and 17.1 ± 3.2 for met/met; p = 0.027 and p = 0.024, respectively. Multiple regression analyses revealed that executive function was significantly correlated with the Val158Met genotype (p = 0.003. However, no evidence was found for an effect of the COMT on any cognitive domains of the BACS-J in the patients with schizophrenia. CONCLUSION: These data support the hypothesis that the COMT Val158Met genotype maintains an optimal level of dopamine activity. Further studies should be performed that include a larger sample size and include patients on and off medication, as these patients would help to confirm our findings.

  8. SAJCC 158.indd

    African Journals Online (AJOL)

    1 Department of Nursing Education, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa ... To assess the knowledge of nurses working in intensive care units (ICUs) in respect of pain management, glycaemic control .... Of the 142 questionnaires distributed, 136 were completed and.

  9. SAJCC 158.indd

    African Journals Online (AJOL)

    literature suggests that the advantages of FWR for families outweigh the disadvantages, and that health professionals can support the practice without hindering the clinical care of patients.[9]. From the researcher's experience, allowing family members to remain with patients during resuscitation efforts is a relatively new.

  10. 158 ORIGINAL ARTICLE

    African Journals Online (AJOL)

    boaz

    Département de microbiologie et immunologie médicale, Faculté de médecine, Université de Zagazig, Egypte. Correspondance: Samar Saeed Morsi ; Email : samarsaeed_76@yahoo.com. RESUME ..... This necessitates continuous surveillance of antimicrobial drug resistance and careful epidemiological monitoring of co- ...

  11. Catechol-O-methyltransferase Val158Met polymorphism on the relationship between white matter hyperintensity and cognition in healthy people.

    Directory of Open Access Journals (Sweden)

    Mu-En Liu

    Full Text Available BACKGROUND: White matter lesions can be easily observed on T2-weighted MR images, and are termed white matter hyperintensities (WMH. Their presence may be correlated with cognitive impairment; however, the relationship between regional WMH volume and catechol-O-methyltransferase (COMT Val158Met polymorphism in healthy populations remains unclear. METHODS: We recruited 315 ethnic Chinese adults with a mean age of 54.9 ± 21.8 years (range: 21-89 y to examine the genetic effect of COMT on regional WMH and the manner in which they interact to affect cognitive function in a healthy adult population. Cognitive tests, structural MRI scans, and genotyping of COMT were conducted for each participant. RESULTS: Negative correlations between the Digit Span Forward (DSF score and frontal WMH volumes (r = -.123, P = .032, uncorrected were noted. For the genetic effect of COMT, no significant difference in cognitive performance was observed among 3 genotypic groups. However, differences in WMH volumes over the subcortical region (P = .016, uncorrected, whole brain (P = .047, uncorrected, and a trend over the frontal region (P = .050, uncorrected were observed among 3 COMT genotypic groups. Met homozygotes and Met/Val heterozygotes exhibited larger WMH volumes in these brain regions than the Val homozygotes. Furthermore, a correlation between the DSF and regional WMH volume was observed only in Met homozygotes. The effect size (cohen's f revealed a small effect. CONCLUSIONS: The results indicate that COMT might modulate WMH volumes and the effects of WMH on cognition.

  12. Association between catechol-O-methyltrasferase Val108/158Met genotype and prefrontal hemodynamic response in schizophrenia.

    Directory of Open Access Journals (Sweden)

    Ryu Takizawa

    Full Text Available BACKGROUND: "Imaging genetics" studies have shown that brain function by neuroimaging is a sensitive intermediate phenotype that bridges the gap between genes and psychiatric conditions. Although the evidence of association between functional val108/158met polymorphism of the catechol-O-methyltransferase gene (COMT and increasing risk for developing schizophrenia from genetic association studies remains to be elucidated, one of the most topical findings from imaging genetics studies is the association between COMT genotype and prefrontal function in schizophrenia. The next important step in the translational approach is to establish a useful neuroimaging tool in clinical settings that is sensitive to COMT variation, so that the clinician could use the index to predict clinical response such as improvement in cognitive dysfunction by medication. Here, we investigated spatiotemporal characteristics of the association between prefrontal hemodynamic activation and the COMT genotype using a noninvasive neuroimaging technique, near-infrared spectroscopy (NIRS. METHODOLOGY/PRINCIPAL FINDINGS: Study participants included 45 patients with schizophrenia and 60 healthy controls matched for age and gender. Signals that are assumed to reflect regional cerebral blood volume were monitored over prefrontal regions from 52-channel NIRS and compared between two COMT genotype subgroups (Met carriers and Val/Val individuals matched for age, gender, premorbid IQ, and task performance. The [oxy-Hb] increase in the Met carriers during the verbal fluency task was significantly greater than that in the Val/Val individuals in the frontopolar prefrontal cortex of patients with schizophrenia, although neither medication nor clinical symptoms differed significantly between the two subgroups. These differences were not found to be significant in healthy controls. CONCLUSIONS/SIGNIFICANCE: These data suggest that the prefrontal NIRS signals can noninvasively detect the impact

  13. $J/\\psi$ production in p-A collisions at 158 and 400 GeV: recent results from the NA60 experiment

    CERN Document Server

    Scomparin, Enrico

    2009-01-01

    The NA60 experiment has studied muon pair production in p-A and In-In collisions at the CERN SPS. We present new results on nuclear effects on J/psi production in p-A at 158 GeV, the same energy used for collecting A-A data at the SPS. We then compare nuclear effects with previous results from fixed target experiments, and with the results obtained from a p-A data sample taken by NA60 at 400 GeV. Based on the 158 GeV results, we calculate the expected J/psi suppression in In-In and Pb-Pb collisions due to cold nuclear matter effects, and we extract a new estimate for the anomalous suppression at SPS energies. Finally, we show preliminary results on J/psi polarization in p-A collisions.

  14. The catechol-O-methyltransferase (COMT) Val158Met genotype modulates working memory-related dorsolateral prefrontal response and performance in bipolar disorder

    DEFF Research Database (Denmark)

    Miskowiak, K. W.; Kjærstad, H. L.; Støttrup, M. M.

    2017-01-01

    -O-methyltransferase (COMT) gene is associated with reduced prefrontal cortex dopamine and exaggerated working memory-related prefrontal activity. This functional magnetic resonance imaging (fMRI) study investigated for the first time whether the COMT Val158Met genotype modulates prefrontal activity during spatial working...... memory in BD. METHODS: Sixty-four outpatients with BD in full or partial remission were stratified according to COMT Val158Met genotype (ValVal [n=13], ValMet [n=34], and MetMet [n=17]). The patients completed a spatial n-back working memory task during fMRI and the Cambridge Neuropsychological Test...... Automated Battery (CANTAB) Spatial Working Memory test outside the scanner. RESULTS: During high working memory load (2-back vs 1-back), Val homozygotes displayed decreased activity relative to ValMet individuals, with Met homozygotes displaying intermediate levels of activity in the right dorsolateral...

  15. Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age

    OpenAIRE

    Chau, Cecil M. Y.; Ranger, Manon; Sulistyoningrum, Dian; Devlin, Angela M.; Oberlander, Tim F.; Grunau, Ruth E.

    2014-01-01

    Children born very preterm are exposed to repeated neonatal procedures that induce pain and stress during hospitalization in the neonatal intensive care unit (NICU). The COMT Val158Met genotype is involved with pain sensitivity, and early life stress is implicated in altered expression of methylation of the serotonin transporter. We examined: (1) whether methylation of the serotonin transporter gene (SLC6A4) promoter differs between very preterm children and full-term controls at school age, ...

  16. Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT

    Directory of Open Access Journals (Sweden)

    Zwart John-Anker

    2008-06-01

    Full Text Available Abstract Background The catechol-O-methyltransferase (COMT gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS in the general adult population. Methods In the Nord-Trøndelag Health Study (HUNT the association between the Val158Met polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals. Two different cut off scores (≥ 8 and ≥ 11 were used to identify cases with anxiety (HADS-A and depression (HADS-D, whereas controls had HADS-A Results The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of ≥ 8. When utilizing the alternative cut-off score HADS-D ≥ 11, Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: p = 0.017, allele: p = 0.006. In the multivariate analysis, adjusting for age and heart disease, depression (HADS-D ≥ 11 was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18–0.76. Conclusion In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely among men with depression defined as HADS-D ≥ 11, but this may be an incidental finding.

  17. β-decay half-lives of neutron-rich nuclei around 158Nd, relevant to the formation of the A≈165 rare-earth element peak

    Directory of Open Access Journals (Sweden)

    Wu J.

    2016-01-01

    Full Text Available A β-decay spectroscopy experiment around 158Nd was performed at RI Beam Factory (RIBF, RIKEN Nishina Center, in order to understand the production mechanism of the A≈165 rare-earth element (REE peak in the r-process mass abundance pattern. In this experiment, 53 half-lives are measured including 34 new results, which could be employed in a fully dynamic r-process network calculation.

  18. The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility

    Science.gov (United States)

    Bushueva, Olga; Solodilova, Maria; Churnosov, Mikhail; Ivanov, Vladimir; Polonikov, Alexey

    2014-01-01

    Gene encoding flavin-containing monooxygenase 3 (FMO3), a microsomal antioxidant defense enzyme, has been suggested to contribute to essential hypertension (EH). The present study was designed to investigate whether common functional polymorphism E158K (rs2266782) of the FMO3 gene is associated with EH susceptibility in a Russian population. A total of 2 995 unrelated subjects from Kursk (1 362 EH patients and 843 healthy controls) and Belgorod (357 EH patients and 422 population controls) regions of Central Russia were recruited for this study. DNA samples from all study participants were genotyped for the FMO3 gene polymorphism through PCR followed by RFLP analysis. We found that the polymorphism E158K is associated with increased risk of essential hypertension in both discovery population from Kursk region (OR 1.36 95% CI 1.09–1.69, P = 0.01) and replication population from Belgorod region (OR 1.54 95% CI 1.07–1.89, P = 0.02) after adjustment for gender and age using logistic regression analysis. Further analysis showed that the increased hypertension risk in carriers of genotype 158KK gene occurred in cigarette smokers, whereas nonsmoker carriers of this genotype did not show the disease risk. This is the first study reporting the association of the FMO3 gene polymorphism and the risk of essential hypertension. PMID:25243081

  19. The effects of catechol-O-methyl-transferase polymorphism Val158Met on functional connectivity in healthy young females: a resting EEG study.

    Science.gov (United States)

    Lee, Tien-Wen; Yu, Younger W-Y; Hong, Chen-Jee; Tsai, Shih-Jen; Wu, Hung-Chi; Chen, Tai-Jui

    2011-03-04

    The catechol-O-methyl-transferase (COMT) gene has been linked to a wide spectrum of human phenotypes, including cognition, affective response, pain sensitivity, anxiety and psychosis. This study examined the modulatory effects of COMT Val158Met on neural interactions, indicated by connectivity strengths. Blood samples and resting state eyes-closed EEG signals were collected in 254 healthy young females. The COMT Val158Met polymorphism was decoded into 3 groups: Val/Val, Val/Met and Met/Met. The values of mutual information of 20 frontal-related channel pairs across delta, theta, alpha and beta frequencies were analyzed based on the time-frequency mutual information method. Our one-way ANOVA analyses revealed that the significant connection-frequency pairs were relatively left lateralized (Pthreshold of PVal/Met>Met/Met. Our analyses complemented previous literature regarding neural modulation by the COMT Val158Met polymorphism. The implication to the pathogenesis in schizophrenia was also discussed. Further studies are needed to clarify whether there is gender difference on this gene-brain interaction. Copyright © 2010 Elsevier B.V. All rights reserved.

  20. Catechol-O-Methyltransferase gene (val158met) polymorphisms and anxious symptoms in early childhood: The roles of hypothalamus-pituitary-adrenal axis reactivity and life stress.

    Science.gov (United States)

    Sheikh, Haroon I; Kryski, Katie R; Kotelnikova, Yuliya; Hayden, Elizabeth P; Singh, Shiva M

    2017-10-17

    Individual differences in hypothalamus-pituitary-adrenal (HPA) axis reactivity to stress (measured via salivary cortisol) have been widely implicated in the etiology of internalizing problems such as depression and anxiety. Literature suggests that stress during early childhood is an important source of contextual risk although its effects may be moderated by polymorphisms of neurotransmitter genes. The COMT val158met is one such polymorphism, and literature documents its link to internalizing problems. To extend these findings, and to better understand the role of this polymorphism in developmental risk, we investigated links between the val158met polymorphism and early-age cortisol response. Additionally, we investigated whether cortisol reactivity mediated the link between COMT and emerging internalizing symptoms. The study was conducted in a community sample of 409 preschoolers. Saliva samples were collected pre-stress task (baseline) and every 10min post-stress task for one-hour to asses cortisol response. Child anxious and depressive symptoms were tabulated based on parent-reports. Markers of early childhood stress included marital discord, socio-economic status and the UCLA Life Stress Interview. Findings indicated that the val158met polymorphism is associated with childhood cortisol response (pstress also predicted child anxiety symptoms (pstress on preschool-age symptoms of anxiety. Additionally, cortisol reactivity acts as a mechanistic mediator of the main-effect of COMT genotype on child anxious symptoms. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. [Association study of the Val158Met polymorphism of the catechol-O-methyltransferase gene and alcoholism and heroin dependence: the role of a family history].

    Science.gov (United States)

    Kibitov, A O; Voskoboeva, E Iu; Brodianskiĭ, V M; Chuprova, N A; Smirnova, E V

    2010-01-01

    The aim of this study was to investigate the association the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene and predisposition to alcoholism and heroin dependence. The authors genotyped DNA samples from 964 Russian males (395 alcoholics, 243 heroin addicts and 326 healthy controls). The association between the Val158Met COMT polymorphism and alcoholism was found in males with high density of family history (two or more blood relatives with alcoholism within the family). In this group, the frequency of a L (Met) allele was significantly higher in comparison with controls (p=0,001), patients without family history (p=0,034) and patients with the mild density of family history (p=0,0005). The frequency of the HH (ValVal) genotype was reduced as well compared to the controls (p=0,003). In the group of heroin addicts with the mild density of family history, there was a trend to lower frequency of the HH genotype (p=0,058) compared to patients without family history. The results suggest that the functional Val158Met COMT polymorphism is one of the significant markers of genetic predisposition to addiction diseases.

  2. The catechol-o-methyltransferase Val158Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects

    Science.gov (United States)

    Zhang, Xiaolong; Li, Jin; Qin, Wen; Yu, Chunshui; Liu, Bing; Jiang, Tianzi

    2015-01-01

    The influence of catechol-o-methyltransferase (COMT) Val158Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of COMT Val158Met genotypes on the connection patterns of the brain network and working memory (WM) in healthy, young Val/Val and Met carrier subjects. There were significant differences in the performance level on the 2-back WM task between the different COMT genotypes: Val/Val individuals exhibited a higher correct rate compared to the Met carriers. A two-sample t test was used to examine the differences in the eigenvector centrality maps, using age and gender as covariates of no interest, between the Val/Val and Met carriers. We found that the Val/Val individuals exhibited significantly higher eigenvector centrality compared to the Met carriers in the left parahippocampal cortex. Furthermore, a significantly positive correlation between the mean eigenvector centrality of the significant cluster and the correct rate of the 2-back WM task was observed. By using a voxel-wise data-driven method, our findings may provide plausible implications regarding individual differences in the genetic contribution of COMT Val158Met to the brain network and cognition. PMID:26054510

  3. The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria

    Directory of Open Access Journals (Sweden)

    Ashton Katie A

    2006-05-01

    Full Text Available Abstract Catechol-O-methyltransferase (COMT is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. The efficiency of this process varies due to a polymorphism in COMT, which changes valine to methionine (V158M. The Met genotypes slow the metabolism of catechol oestrogens, which are agents that are capable of causing DNA damage through the formation of DNA adducts and reactive oxygen species (ROS production. The slower metabolism of catechol oestrogens results in there being a higher circulating concentration of these oeastrogens and consequently greater probability of DNA damage. To determine whether metabolic inefficiencies of oeastrogen metabolism are associated with the development of malignancy in hereditary non-polyposis colorectal cancer (HNPCC, we studied the V158M polymorphism in COMT in a large cohort of 498 HNPCC patients from Australia and Poland that were either mutation positive (n = 331 or negative (n = 167 for mismatch repair (MMR gene mutations (hMLH1 or hMSH2. HNPCC is a familial predisposition to colorectal cancer (CRC and extracolonic cancers that include endometrial cancer. Using Real Time PCR, the COMT V158M polymorphism was examined and its association with disease expression, age of diagnosis of cancer, mutation status and mutation type was assessed in the HNPCC MMR mutation positive and negative groups. This study showed that the V158M polymorphism had no association with disease risk in the HNPCC MMR mutation positive population. However, the polymorphism was significantly associated with endometrial/ovarian cancer risk in HNPCC MMR mutation negative patients (p = 0.002. The heterozygous (Val/Met genotype was associated with an increased risk of developing endometrial/ovarian cancer whereas the homozygous mutant (Met/Met showed a decreased risk. The results suggest heterosis, where there is an apparent greater effect of the heterozygous state in this dichotomous trait. In

  4. Spectroscopic analysis of lithium terbium tetrafluoride

    DEFF Research Database (Denmark)

    Christensen, H.P.

    1978-01-01

    . The rare-earth site in LiTbF4 possesses S4 symmetry, which allows six crystal-field parameters. ζ and the six Bim were varied to obtain the best agreement with the experimentally observed levels. Keeping F2=434 cm-1 fixed, a fit with a standard deviation of 12 cm-1 was obtained at 10 K with the following...... were calculated by diagonalizing an effective spin-orbit and crystal-field Hamiltonian in an LS basis. H=Σλi(L→·S→)i+ΣαiΣBimOim, where the parameters λi are functions of the spin-orbit parameter ζ and the Slater parameter F2. The Oim and αi are Racah operators and reduced matrix elements, respectively...

  5. Inelastic critical scattering of neutrons from terbium

    DEFF Research Database (Denmark)

    Als-Nielsen, Jens Aage; Dietrich, O.W.; Marshall, W.

    1967-01-01

    We have measured the inelasticity of the critical neutron scattering in Tb above the Néel temperature. The results show that dynamical slowing down of fluctuations does occur at a second order phase transition.......We have measured the inelasticity of the critical neutron scattering in Tb above the Néel temperature. The results show that dynamical slowing down of fluctuations does occur at a second order phase transition....

  6. Task demands, tDCS intensity, and the COMT val158met polymorphism impact tDCS-linked working memory training gains.

    Science.gov (United States)

    Stephens, Jaclyn A; Jones, Kevin T; Berryhill, Marian E

    2017-10-18

    Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val158met, DAT, BDNF val66met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided DNA samples and received Visual and Spatial WM training paired with tDCS (sham, 1, 1.5, 2 mA). After one session of tDCS, significant group differences in WM performance were predicted by COMT val158met status. One month after training, there was a significant interaction of tDCS intensity, COMT genotype, and WM task. Specifically, val/val homozygotes benefited most from 1.5 mA tDCS on Visual WM and from 1 mA tDCS on Spatial WM. For met/met homozygotes, 2 mA resulted in significantly poorer performance compared to 1.5 mA on Spatial WM. While this pattern was observed with relatively small sample sizes, these data indicate that variations in COMT val158met may predict the nature of WM improvement after initial and longitudinal tDCS. This contributes to our understanding of the underlying mechanism by which tDCS affects behaviour.

  7. The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers

    Directory of Open Access Journals (Sweden)

    Borda Sandra

    2009-09-01

    Full Text Available Abstract Background The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT gene (polymorphism Val158 Met as a risk factor for Alzheimer's disease (AD and mild cognitive impairment of amnesic type (MCI, and its synergistic effect with the apolipoprotein E gene (APOE. A total of 223 MCI patients, 345 AD and 253 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups. The DNA Bank of the University of the Basque Country (UPV-EHU (Spain determined COMT Val158 Met and APOE genotypes using real time polymerase chain reaction (rtPCR and polymerase chain reaction (PCR, and restriction fragment length polymorphism (RFLPs, respectively. Multinomial logistic regression models were used to determine the risk of AD and MCI. Results Neither COMT alleles nor genotypes were independent risk factors for AD or MCI. The high activity genotypes (GG and AG showed a synergistic effect with APOE ε4 allele, increasing the risk of AD (OR = 5.96, 95%CI 2.74-12.94, p In MCI patients such as synergistic effect was only found between AG and APOE ε4 allele (OR = 3.21 95%CI 1.56-6.63, p = 0.02 and was greater in men (OR = 5.88 95%CI 1.69-20.42, p Conclusion COMT (Val158 Met polymorphism is not an independent risk factor for AD or MCI, but shows a synergistic effect with APOE ε4 allele that proves greater in women with AD.

  8. Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome.

    Science.gov (United States)

    Fernández-de-Las-Peñas, César; Ambite-Quesada, Silvia; Gil-Crujera, Antonio; Cigarán-Méndez, Margarita; Peñacoba-Puente, Cecilia

    2012-11-01

    Our aim was to assess the relationship of the Val158Met polymorphism to pain, anxiety, depression, functional ability, and pressure pain sensitivity in women with fibromyalgia (FMS). One hundred (n = 100) women with FMS diagnosed according to the American College of Rheumatology criteria participated. A numerical pain rate scale (0-10) was used to assess the intensity of pain; the Hospital Anxiety and Depression Scale was calculated to determine anxiety and depression; and functional ability was determined with the Fibromyalgia Impact Questionnaire. Further, pressure pain thresholds (PPTs) were bilaterally assessed over C5-C6 zygapophyseal joints, second metacarpal, and tibialis anterior muscles. Finally, after amplifying Val158Met polymorphisms by polymerase chain reaction, catechol-O-methyltransferase (COMT) genotype was divided into Val/Val, Val/Met, or Met/Met genotypes. Women with FMS with the Met/Met genotype exhibited higher disability (F = 11.836; P anxiety (F = 13.385; P anxiety but similar PPTs than those with Val/Met or Val/Val genotypes. This study is important because it strives to understand potential genetic factors that predispose some women with FMS to exhibit a more severe phenotypic expression of the disease. Future studies are needed to elucidate potential relevance of the differences. This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but not pressure pain sensitivity in FMS because women with FMS carrying the Met/Met genotype exhibit higher disability, depression, and anxiety than but similar PPTs to those with Val/Met and Val/Val genotypes. This study provides further evidence of potential genetic factors that predispose women with FMS to exhibit the disease more severely. Copyright © 2012 American Pain Society. Published by Elsevier Inc. All rights reserved.

  9. Enhancement of strange and multi-strange baryons in central Pb-Pb interactions at 158 GeV/c per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Antinori, F.; Bakke, H.; Beusch, W.; Bloodworth, I.J.; Caliandro, R.; Carrer, N.; Di Bari, D.; Di Liberto, S.; Elia, D.; Evans, D.; Fanebust, K.; Fini, R.A.; Ftacnik, J.; Ghidini, B.; Grella, G.; Helstrup, H.; Holme, A.K.; Huss, D.; Jacholkowski, A.; Jones, G.T.; Kinson, J.B.; Knudson, K.; Kralik, I.; Lenti, V.; Lietava, R.; Loconsole, R.A.; Loevhoeiden, G.; Manzari, V.; Mazzoni, M.A.; Meddi, F.; Michalon, A.; Michalon-Mentzer, M.E.; Morando, M.; Norman, P.I.; Pastircak, B.; Quercigh, E.; Romano, G.; Safarik, K.; Sandor, L.; Segato, G.; Staroba, P.; Thompson, M.; Thorsteinsen, T.F.; Torrieri, G.D.; Tveter, T.S.; Urban, J.; Baillie, O. Villalobos; Virgili, T.; Votruba, M.F.; Zavada, P

    2000-01-31

    Strange and multi-strange baryon production is expected to be enhanced in heavy ion interactions if a phase transition from hadronic matter to a Quark-Gluon Plasma takes place. The production yields and transverse mass spectra of strange and multi-strange baryons and anti-baryons are presented for lead-lead interactions at 158 GeV/c per nucleon. Yields and transverse mass spectra from proton-lead and proton-beryllium interactions, where no phase transition is expected, are also presented and compared to those from lead-lead interactions.

  10. Freeze-Out Parameters in Central 158A GeV P{number_sign}208 b+Pb Collision80s

    Energy Technology Data Exchange (ETDEWEB)

    Aggarwal, M.M.; Bhatia, V.S. [University of Panjab, Chandigarh 160014 (India); Agnihotri, A.; Bhalla, K.B.; Gupta, S.K.; Raniwala, R.; Raniwala, S. [University of Rajasthan, Jaipur 302004, Rajasthan (India); Ahammed, Z.; Chattopadhyay, S.; Das, A.C.; Dutta Majumdar, M.R.; Ganti, M.S.; Mukhopadhyay, D.S.; Nayak, T.K.; Sinha, B.C.; Trivedi, M.D.; Viyogi, Y.P. [Variable Energy Cyclotron Centre, Calcutta 700 064 (India); Angelis, A.L.; Donni, P.; Foka, P.; Kalechofsky, H.; Martin, M.; Naef, H.; Rosselet, L.; Rubio, J.M.; Solomey, N.; Voeroes, S. [University of Geneva, CH-1211 Geneva 4 (Switzerland); Antonenko, V.; Cherbatchev, R.; Doubovik, I.; Fokin, S.; Ippolitov, M.; Karadjev, K.; Koutcheryaev, I.; Lebedev, A.; Manko, V.; Mgebrichvili, G.; Nianine, A.; Sibiriak, I.; Tsvetkov, A.; Vinogradov, A. [RRC Kurchatov Institute, RU-123182 Moscow (Russia); Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Baldine, A.; Barabach, L.; Batiounia, B.; Chalyshev, V.; Djordjadze, V.; Frolov, V.; Gavrishchuk, O.; Guskov, B.; Kosarev, I.; Kuzmin, N.; Maximov, A.; Mehdiyev, R.; Mikhalev, D.; Myalkovski, V.; Nikitine, V.; Nikolaev, S.; Nomokonov, P.; Parfenov, A.; Pavliouk, S.; Roufanov, I.; Shabratova, G.; Slavine, N.; Vodopianov, A. [Joint Institute for Nuclear Research, RU-141980 Dubna (Russia); Awes, T.C.; Kim, H.; Plasil, F.; Stankus, P.; Young, G.R. [Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6372 (United States); Baba, P.V.; Badyal, S.K.; Dutt, S.; Mir, M.F.; Rao, N.K.; Sambyal, S.S.; Shah, T.H. [University of Jammu, Jammu 180001 (India); Barlag, C.; Bathe, S.; Blume, C.; Bohne, E.; Boeroecz, Z.K.; Bucher, D.; Buesching, H.; Claussen, A.; Glasow, R.; Kampert, K.; Kees, S.; Kruempel, T.; Peitzmann, T.; Reygers, K.; Santo, R.; Schlagheck, H.; Stueken, D. [University of Muenster, D-48149 Muenster (Germany); Bernier, T.; Delagrange, H.; Gutbrod, H.H.; Luquin, L.; Martinez, G.; Nayak, S.K.; Pinganaud, W.; Retiere, F.; Roy, C.; Schutz, Y. and others

    1999-08-01

    Neutral pion production in central 158A GeV {sup 208}Pb+ {sup 208} Pb collisions has been studied in the WA98 experiment at the CERN Super Proton Synchrotron. The {pi}{sup 0} transverse mass spectrum has been analyzed in terms of a thermal model with hydrodynamic expansion. The high accuracy and large kinematic coverage of the measurement allow one to limit previously noted ambiguities in the extracted freeze-out parameters. The results are shown to be sensitive to the shape of the velocity distribution at freeze-out. {copyright} {ital 1999} {ital The American Physical Society }

  11. Successful Establishment of Plasmids R1 and pMV158 in a New Host Requires the Relief of the Transcriptional Repression of Their Essential rep Genes

    Directory of Open Access Journals (Sweden)

    José Á. Ruiz-Masó

    2017-12-01

    Full Text Available Although differing in size, encoded traits, host range, and replication mechanism, both narrow-host-range theta-type conjugative enterobacterial plasmid R1 and promiscuous rolling-circle-type mobilizable streptococcal plasmid pMV158 encode a transcriptional repressor protein, namely CopB in R1 and CopG in pMV158, involved in replication control. The gene encoding CopB or CopG is cotranscribed with a downstream gene that encodes the replication initiator Rep protein of the corresponding plasmid. However, whereas CopG is an auto-repressor that inhibits transcription of the entire copG-repB operon, CopB is expressed constitutively and represses a second, downstream promoter that directs transcription of repA. As a consequence of the distinct regulatory pathways implied by CopB and CopG, these repressor proteins play a different role in control of plasmid replication during the steady state: while CopB has an auxiliary role by keeping repressed the regulated promoter whenever the plasmid copy number is above a low threshold, CopG plays a primary role by acting coordinately with RNAII. Here, we have studied the role of the regulatory circuit mediated by these transcriptional repressors during the establishment of these two plasmids in a new host cell, and found that excess Cop repressor molecules in the recipient cell result in a severe decrease in the frequency and/or the velocity of appearance of transformant colonies for the cognate plasmid but not for unrelated plasmids. Using the pMV158 replicon as a model system, together with highly sensitive real-time qPCR and inverse PCR methods, we have also analyzed the effect of CopG on the kinetics of repopulation of the plasmid in Streptococcus pneumoniae. We show that, whereas in the absence of CopG pMV158 repopulation occurs mainly during the first 45 min following plasmid transfer, the presence of the transcriptional repressor in the recipient cell severely impairs the replicon repopulation and makes

  12. Rapidity distributions around mid-rapidity of strange particles in Pb-Pb collisions at 158 $A$ GeV/c

    CERN Document Server

    Antinori, F.; Badala, A.; Barbera, R.; Belogianni, A.; Bloodworth, I.J.; Bombara, M.; Bruno, G.E.; Bull, S.A.; Caliandro, R.; Campbell, M.; Carena, Wisla; Carrer, N.; Clarke, R.F.; Dainese, A.; Di Bari, D.; Di Liberto, S.; Divia, R.; Elia, D.; Evans, D.; Feofilov, G.A.; Fini, R.A.; Ganoti, P.; Ghidini, B.; Grella, G.; Helstrup, H.; Hetland, K.F.; Holme, A.K.; Jacholkowski, A.; Jones, G.T.; Jovanovic, P.; Jusko, A.; Kamermans, R.; Kinson, J.B.; Knudson, K.; Kondratiev, V.; Kralik, I.; Kravcakova, A.; Kuijer, P.; Lenti, V.; Lietava, R.; Lovhoiden, G.; Manzari, V.; Mazzoni, M.A.; Meddi, F.; Michalon, A.; Morando, M.; Norman, P.I.; Palmeri, A.; Pappalardo, G.S.; Pastircak, B.; Platt, R.J.; Quercigh, E.; Riggi, F.; Rohrich, D.; Romano, G.; Safarik, K.; Sandor, L.; Schillings, E.; Segato, G.; Sene, M.; Sene, R.; Snoeys, W.; Soramel, F.; Spyropoulou-Stassinaki, M.; Staroba, P.; Turrisi, R.; Tveter, T.S.; Urban, J.; van de Ven, P.; Vande Vyvre, P; Vascotto, A.; Vik, T.; Villalobos Baillie, O.; Vinogradov, L.; Virgili, T.; Votruba, M.F.; Vrlakova, J.; Zavada, P.

    2005-01-01

    The production at central rapidity of K0s, Lambda, Xi and Omega particles in Pb-Pb collisions at 158 A GeV/c has been measured by the NA57 experiment over a centrality range corresponding to the most central 53% of the inelastic Pb-Pb cross section. In this paper we present the rapidity distribution of each particle in the central rapidity unit as a function of the event centrality. The distributions are analyzed based on hydrodynamical models of the collisions.

  13. Bose-Einstein Correlations of Charged Kaons in Central Pb+Pb Collisions at $E_{beam} = 158 AGeV$

    CERN Document Server

    Afanasiev, S V; Baatar, B; Barna, D; Bartke, J; Barton, R A; Behler, M; Betev, L; Białkowska, H; Billmeier, A; Blume, C; Blyth, C O; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Bunčić, P; Cerny, V; Chvala, O; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Filip, P; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gaździcki, M; Georgopoulos, G; Gładysz, E; Hegyi, S; Höhne, C; Igo, G; Jones, P G; Kadija, K; Karev, A; Kolesnikov, V I; Kollegger, T; Kowalski, M; Kraus, I; Kreps, M; van Leeuwen, M; Lednicky, R; Lévai, P; Malakhov, A I; Margetis, S; Markert, C; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Nelson, John M; Pálla, G; Panagiotou, A D; Perl, K; Petridis, A; Pikna, M; Pinsky, Lawrence S; Pühlhofer, F; Reid, J G; Renfordt, R; Retyk, W; Roland, C; Roland, G; Rybicki, A; Sammer, T; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitar, B; Skrzypczak, E; Squier, G T A; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, M; Veres, G I; Vesztergombi, G; Vranić, D; Wetzler, A; Whitten, C; Yoo, I K; Zaranek, J; Zimányi, J; 10.1016/S0370-2693(03)00102-3

    2003-01-01

    Bose-Einstein correlations of charged kaons were measured near mid-rapidity in central Pb+Pb collisions at 158 A$\\cdot$GeV by the NA49 experiment at the CERN SPS. Source radii were extracted using the Yano-Koonin-Podgoretsky and Bertsch-Pratt parameterizations. The results are compared to published pion data. The measured $m_\\perp$ dependence for kaons and pions is consistent with collective transverse expansion of the source and a freeze-out time of about 9.5 $fm$.

  14. Lambda and $\\overline{Lambda}$ production in central Pb-Pb collisions at 40, 80, and 158A GeV

    CERN Document Server

    Anticic, T; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Litov, L; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R E; Retyk, W; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2004-01-01

    Production of Lambda and Antilambda hyperons was measured in central Pb-Pb collisions at 40, 80, and 158A GeV beam energy on a fixed target. Transverse mass spectra and rapidity distributions are given for all three energies. The Lambda / pi ratio at midrapidity and in full phase space shows a pronounced maximum between the highest BNL Alternating Gradient Synchrotron and 40A GeV CERN Super Proton Synchrotron energies, whereas the Lambda / pi ratio exhibits a monotonic increase. (36 refs).

  15. Directed and elliptic flow of charged pions and protons in Pb+Pb collisions at 40 and 158 AGeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, J; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Borghini, N; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Chvala, O; Cooper, G E; Cramer, J G; Csató, P; Dinh, P M; Dinkelaker, P; Eckardt, V; Filip, P; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Hegyi, S; Höhne, C; Jacobs, P; Kadija, K; Karev, A; Kniege, S; Kolesnikov, V I; Kollegger, T; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Van Leeuwen, M; Lévai, Peter; Malakhov, A I; Markert, C; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Odyniec, Grazyna Janina; Ollitrault, J Y; Pálla, G; Panagiotou, A D; Perl, K; Petridis, A; Pikna, M; Pinsky, L; Poskanzer, A M; Pühlhofer, F; Reid, J G; Renfordt, R; Retyk, W; Ritter, H G; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Snellings, R J; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, M; Veres, G I; Vesztergombi, G; Voloshin, S A; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J

    2003-01-01

    Directed and elliptic flow measurements for charged pions and protons are reported as a function of transverse momentum, rapidity, and centrality for 40 and 158 AGeV Pb + Pb collisions as recorded by the NA49 detector. Both the standard method of correlating particles with an event plane, and the cumulant method of studying multiparticle correlations are used. In the standard method the directed flow is corrected for conservation of momentum. In the cumulant method elliptic flow is reconstructed from genuine 4, 6, and 8-particle correlations, showing the first unequivocal evidence for collective motion in A+A collisions at SPS energies.

  16. Electric charge fluctuations in central Pb+Pb collisions at 20A, 30A, 40A, 80A, and 158A GeV

    CERN Document Server

    Alt, C; Baatar, B; Barna, D; Bartke, Jerzy; Behler, M; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Boimska, B; Botje, M; Bracinik, J; Bramm, R; Brun, R; Buncic, P; Cerny, V; Christakoglou, P; Chvala, O; Cramer, J G; Csató, P; Darmenov, N; Dimitrov, A; Dinkelaker, P; Eckardt, V; Filip, P; Flierl, D; Fodor, Z; Foka, P; Freund, P; Friese, V; Gál, J; Gazdzicki, M; Georgopoulos, G; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kliemant, M; Kniege, S; Kolesnikov, V I; Kollegger, T; Kornas, E; Korus, R; Kowalski, M; Kraus, I; Kreps, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Markert, C; Mateev, M; Mayes, B W; Melkumov, G L; Meurer, C; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Pikna, M; Pinsky, L; Pühlhofer, F; Reid, J G; Renfordt, R; Richard, A; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Sann, H; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Stefanek, G; Stock, R; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Trainor, T A; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Vranic, D; Wetzler, A; Wlodarczyk, Z; Yoo, I K; Zaranek, J; Zimányi, J; Van Leeuwen, M

    2004-01-01

    Results are presented on event-by-event electric charge fluctuations in central Pb+Pb collisions at 20A, 30A, 40A, 80A, and 158A GeV. The observed fluctuations are close to those expected for a gas of pions correlated by global charge conservation only. These fluctuations are considerably larger than those calculated for an ideal gas of deconfined quarks and gluons. The present measurements do not necessarily exclude reduced fluctuations from a quark-gluon plasma because these might be masked by contributions from resonance decays.

  17. Mycelial glucoamylases produced by the thermophilic fungus Scytalidium thermophilum strains 15.1 and 15.8: purification and biochemical characterization Glucoamilases miceliais produzidas pelas linhagens 15.1 e 15.8 do fungo termofílico Scytalidium thermophilum: purificação e caracterização bioquímica

    Directory of Open Access Journals (Sweden)

    M.S. Ferreira-Nozawa

    2008-06-01

    Full Text Available Two strains (15.1 and 15.8 of the thermophilic fungus Scytalidium thermophilum produced high levels of intracellular glucoamylases, with potential for industrial applications. The isoform I of the glucoamylase produced by 15.1 strain was sequentially submitted to DEAE-Cellulose and CM-Cellulose chromatography, and purified 141-fold, with 5.45% recovery. The glucoamylase of strain 15.8 was purified 71-fold by CM-Cellulose and Concanavalin A-Sepharose chromatography, with 7.38% recovery. Temperature and pH optima were in the range of 50-60ºC and 5.0-6.0, respectively, using starch and maltose as substrates. The glucoamylase of S. thermophilum 15.8 was more stable (t50 > 60 min than that of S. thermophilum 15.1 (t50= 11-15 min, at 60ºC. The glucoamylase activities were enhanced by several ions (e.g. Mn2+ and Ca2+ and inhibited by β-mercaptoethanol. The glucoamylase from 15.1 strain showed a Km of 0.094 mg/ml and 0.029 mg/ml and Vmax of 202 U/mg prot and 109 U/mg prot, for starch and maltose, respectively. The hydrolysis products of starch and maltose, analyzed by TLC, demonstrated glucose as end product and confirming the character of the enzyme as glucoamylase. Differences were observed in relation to the products formed with maltose as substrate between the two strains studied. S. thermophilum 15.8 formed maltotriose in contrast with S. thermophilum 15.1.Duas linhagens (15.1 e 15.8 do fungo termofílico Scytalidium thermophilum se mostraram produtoras de grandes quantidades de glucoamilases, com potencial aplicação industrial. A isoforma I de glucoamilase produzida pela linhagem 15.1 foi submetida seqüencialmente a cromatografia em colunas de DEAE-celulose e CM-celulose, sendo purificada 141 vezes com porcentagem de recuperação de 5,45%. A glucoamilase da linhagem 15.8 foi purificada 71 vezes através do uso de colunas de cromatografia de CM-celulose e Concanavalina A-sepharose com porcentagem de recuperação de 7,38%. Temperatura e pH

  18. Effect of schizotypy on cognitive performance and its tuning by COMT val158 met genotype variations in a large population of young men.

    Science.gov (United States)

    Smyrnis, Nikolaos; Avramopoulos, Dimitrios; Evdokimidis, Ioannis; Stefanis, Costas N; Tsekou, Hara; Stefanis, Nicholas C

    2007-04-01

    Mirroring schizophrenia, specific dimensions of schizotypy are related to cognitive dysfunction. The relation of schizotypy and state psychopathology to cognitive performance and its link to catechol-O-methyltransferase (COMT) val(158) met genotype variations was studied in a large sample of young men. State psychopathology and schizotypy were assessed with self-rated questionnaires. Cognitive performance was assessed with tests of reasoning ability, sustained attention, and verbal and spatial working memory. Subjects were genotyped for the val(158) met polymorphism of the gene for COMT (low enzymatic activity met/met, intermediate met/val, and high val/val). The val/val group had higher scores in measures of state psychopathology as well as negative and disorganized schizotypy dimensions, whereas there was no effect of COMT genotype on cognitive performance measures. Structural equation modeling showed that cognitive performance accuracy but not speed decreased with increasing negative schizotypy, increased with increasing paranoid schizotypy, and was not affected by state psychopathology. Increasing val loading resulted in a dose-dependent increase in the factor loading for the relation between negative schizotypy and cognitive performance accuracy. Different schizotypal phenotypes had opposing relations to cognitive performance in the population. COMT genotype modulated the relation between the negative schizotypal phenotype and cognitive performance.

  19. The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorbid cannabis use in Turkish male patients with schizophrenia.

    Science.gov (United States)

    Ermis, Aysegul; Erkiran, Murat; Dasdemir, Selcuk; Turkcan, Ayse Solmaz; Ceylan, Mehmet Emin; Bireller, Elif Sinem; Cakmakoglu, Bedia

    2015-01-01

    One of the risk factors for increasing psychotic disorders is the use of cannabis. It has been shown that the inactivation of dopamine and other catecholamines causes a common polymorphism generating substantial variations in COMT enzyme activity. We aimed to understand the role of cannabis in the etiology of schizophrenia with and without pre-morbid usage. The study group consisted of 80 male patients and genotyping of COMT enzyme Val158Met gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). It was found that the Val/Val genotype is significantly higher in patients with premorbid cannabis use (88.9%) compared to patients without pre-morbid cannabis use (68.4%). Also, the mean total positive and negative syndrome scale (PANSS) score seen in the Val/Val genotype group is significantly higher than the scores of the patients with the Met allele. The findings from this study confirm the association between COMT Val158 Met polymorphism and pre-morbid cannabis use in causing schizophrenia. Copyright © 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  20. Artificial antigen-presenting cells expressing AFP(158-166) peptide and interleukin-15 activate AFP-specific cytotoxic T lymphocytes.

    Science.gov (United States)

    Sun, Longhao; Guo, Hao; Jiang, Ruoyu; Lu, Li; Liu, Tong; Zhang, Zhixiang; He, Xianghui

    2016-04-05

    Professional antigen-presenting cells (APCs) are potent generators of tumor antigen-specific cytotoxic T lymphocytes (CTLs) for adoptive immunotherapy; however, generation of APCs is cumbersome, expensive, and subject to the tumor microenvironment. Artificial APCs (aAPCs) have been developed as a cost-effective alternative to APCs. We developed a cellular aAPC that efficiently generated alpha-fetoprotein (AFP)-specific CTLs. We genetically modified the human B cell lymphoma cell line BJAB with a lentiviral vector to establish an aAPC called BA15. The expression of AFP(158-166)-HLA-A*02:01 complex, CD80, CD86, and interleukin (IL)-15 in BA15 cells was assessed. The efficiency of BA15 at generating AFP-specific CTLs and the specific cytotoxicity of CTLs against AFP+ cells were also determined. BA15 cells expressed high levels of AFP(158-166) peptide, HLA-A2, CD80, CD86, and IL-15. BA15 cells also exhibited higher efficiency in generating AFP-specific CTLs than did dendritic cells. These CTLs had greater cytotoxicity against AFP+ hepatocellular carcinoma cells than did CTLs obtained from dendritic cells in vitro and in vivo. Our novel aAPC system could provide a robust platform for the generation of functional AFP-specific CTLs for adoptive immunotherapy of hepatocellular carcinoma.

  1. Measurement of resonance production in pion-carbon interactions at 158 and 350 GeV/c with NA61/SHINE

    Energy Technology Data Exchange (ETDEWEB)

    Herve, Alexander [KIT, Karlsruhe (Germany); Collaboration: NA61/SHINE-Collaboration

    2016-07-01

    The interpretation of extensive air shower measurements, produced by ultra-high energy cosmic rays, relies on the correct modelling of the hadron-air interactions that occur during the shower development. The majority of hadronic particles is produced at equivalent beam energies below the TeV range. NA61/SHINE is a fixed target experiment at the CERN Super Proton Synchrotron, studying hadron production in hadron-nucleus and nucleus-nucleus collisions to provide valuable contributions to a number of subjects, from neutrino through cosmic-ray to heavy-ion physics. Pion-Carbon interactions have been performed, at 158 and 350 GeV/c, to give precise particle production measurements for the most numerous projectile in air showers, the π meson. The ability to measure the production of resonances, such as the ρ{sup 0} and ω mesons, is particularly important to predict the number of muons produced in air showers. In this contribution we present updated results of resonance spectra at 158 and 350 GeV/c measured by NA61/SHINE.

  2. Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children.

    Science.gov (United States)

    Cote, A T; Panagiotopoulos, C; Devlin, A M

    2015-02-01

    Second-generation antipsychotic (SGA) medications are associated with cardiometabolic risk factors such as obesity and elevated blood pressure (BP) in some individuals. The goal of this study is to determine whether the Val158Met variant (rs4680) in the catechol-O-methyltransferase (COMT) gene, associated with BP in adults, is associated with elevated BP in SGA-treated children. A cross-sectional population of SGA-treated (n=134) and SGA-naive (n=168) children, ⩽18 years of age, were genotyped and assessed for markers of cardiometabolic health. An interaction was found between SGA treatment and COMT genotype for BP. After adjusting for covariates, SGA-treated children with the Met allele had higher systolic and diastolic BP (P=0.014 and P=0.034, respectively), and higher fasting glucose concentrations (P=0.030) compared with children with the Val/Val genotype. This was not observed in SGA-naive children. The Met allele of the COMT Val158Met variant may identify SGA-treated children at risk for elevated BP and fasting blood glucose concentrations.

  3. The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism.

    Science.gov (United States)

    Kolassa, Iris-Tatjana; Kolassa, Stephan; Ertl, Verena; Papassotiropoulos, Andreas; De Quervain, Dominique J-F

    2010-02-15

    The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose-response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders. Traumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda. Higher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose-response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose-response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load. The present findings indicate a gene-environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD. 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  4. TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-κB activation

    Science.gov (United States)

    Fan, Yihui; Yu, Yang; Mao, Renfang; Zhang, Hong; Yang, Jianhua

    2010-01-01

    The nuclear factor kappa B (NF-κB) transcription factors-mediated transcription is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli. Both the proteolytic and non-proteolytic functions of ubiquitination are critically important for the regulation of NF-κB activation. Lys63-linked polyubiqutination of TAK1 is required for IL-1β-induced IKK/NF-κB activation. However, the lysine site that mediates Lys63-linked TAK1 polyubiquitination in IL-1β signaling is still controversial. Here we report that TAK1 lysine 158 but not lysine 209 is required for IL-1β-induced Lys63-linked TAK1 polyubiquitination and TAK1-mediated IKK, JNK, and p38 activation. Co-overexpression of TAK1 wild-type and K209R mutant with TAB1 induced Lys63-linked TAK1 polyubiquitination and NF-κB activation whereas TAK1 K158R mutant failed to do so. Furthermore, IL-1β induces polyubiqutination of TAK1 wild-type and K209R mutant but not K158R mutant. Reconstitution of TAK1-deficient mouse embryo fibroblast cells with wild-type, K158R mutant, or K209R mutant TAK1 reveals that TAK1 Lys-158 but not Lys-209 is required for IL-1β-induced IKK, p38 and JNK activation. PMID:21130870

  5. Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N

    Directory of Open Access Journals (Sweden)

    Asmaa Badreddine

    2017-10-01

    Full Text Available Argan oil is widely used in Morocco in traditional medicine. Its ability to treat cardiovascular diseases is well-established. However, nothing is known about its effects on neurodegenerative diseases, which are often associated with increased oxidative stress leading to lipid peroxidation and the formation of 7-ketocholesterol (7KC resulting from cholesterol auto-oxidation. As 7KC induces oxidative stress, inflammation and cell death, it is important to identify compounds able to impair its harmful effects. These compounds may be either natural or synthetic molecules or mixtures of molecules such as oils. In this context: (i the lipid profiles of dietary argan oils from Berkane and Agadir (Morocco in fatty acids, phytosterols, tocopherols and polyphenols were determined by different chromatographic techniques; and (ii their anti-oxidant and cytoprotective effects in 158N murine oligodendrocytes cultured with 7KC (25–50 µM; 24 h without and with argan oil (0.1% v/v or α-tocopherol (400 µM, positive control were evaluated with complementary techniques of cellular and molecular biology. Among the unsaturated fatty acids present in argan oils, oleate (C18:1 n-9 and linoleate (C18:1 n-6 were the most abundant; the highest quantities of saturated fatty acids were palmitate (C16:0 and stearate (C18:0. Several phytosterols were found, mainly schottenol and spinasterol (specific to argan oil, cycloartenol, β-amyrin and citrostadienol. α- and γ-tocopherols were also present. Tyrosol and protocatechic acid were the only polyphenols detected. Argan and extra virgin olive oils have many compounds in common, principally oleate and linoleate, and tocopherols. Kit Radicaux Libres (KRL and ferric reducing antioxidant power (FRAP tests showed that argan and extra virgin olive oils have anti-oxidant properties. Argan oils were able to attenuate the cytotoxic effects of 7KC on 158N cells: loss of cell adhesion, cell growth inhibition, increased plasma

  6. Event-by-event fluctuations of the particle yield ratios in heavy-ion collisions at 20 - 158 AGeV

    Energy Technology Data Exchange (ETDEWEB)

    Kresan, Dmytro

    2010-12-22

    Non-statistical event-by-event fluctuations are considered as an important signal for the critical endpoint of the QCD phase diagram. Event-by-event fluctuations of different observables are thus investigated in detail in current experiments but are also an important observable to be studied at the future CBM experiment at FAIR. In this work we present the energy and centrality dependence of event-by-event fluctuations of particle yield ratios measured by the NA49 experiment in Pb+Pb collisions at 20-158 AGeV. Systematic studies of the influence of the dE/dx resolution on the particle identification and the centrality bin size were performed. Results can be compared to event-by-event fluctuations measured by NA49 for different observables such as or the mean charged particle multiplicity. Main results of these studies are an increase of absolute value of the dynamical particle ratio fluctuations with decreasing centrality for all considered ratios, saturation of the K/{pi} and K/p ratio fluctuations for peripheral Pb + Pb collisions at 158A GeV and scaling of the energy and centrality dependences of the p/{pi} ratio fluctuations with N{sub p}N{sub {pi}}. The measured energy and centrality dependences of the K/{pi} and K/p ratio fluctuations scale with N{sub K} in a different way. The saturation of the mentioned ratios fluctuations was attributed to the development of pronounced spike at zero in the eventwise ratio distributions, which, as was shown by Monte Carlo simulations, influence the measured fluctuations in the very peripheral Pb + Pb collisions at 158A GeV. In future, the CBM experiment at FAIR will investigate the intermediate region of the QCD phase diagram in great detail searching for the first order phase transition line and the expected critical endpoint. It is therefore important to closely investigate its sensitivity towards particle ratio fluctuations in Au+Au collisions at 10-45 AGeV beam energy. Detailed simulation studies are

  7. Pion Interferometry from a Relativistic Fluid with a First Order Phase Transition in CERN-SPS 158 GeV/A Pb+Pb Collisions

    CERN Document Server

    Morita, K; Nakamura, H; Nonaka, C

    2000-01-01

    We investigate pion source sizes through the Yano-Koonin-Podgoretski\\u{\\i} (YKP) parametrization for the Hanbury-Brown Twiss (HBT) effect in the CERN-SPS 158 GeV/A central collisions. We calculate two-particle correlation functions numerically based on a (3+1)-dimensional relativistic hydrodynamics with a first order phase transition and analyze the pair momentum dependence of the HBT radii extracted from the YKP parametrization in detail. We find that even in the case of a first order phase transition, expansion and the surface dominant freeze-out make the source in the hydrodynamical model opaque significantly. Consequently, the interpretation of the temporal radius parameter as the time duration becomes unavailable for the hydrodynamical model.

  8. The Role of the Catechol-o-methyltransferase (COMT) Gene Val158Met in Aggressive Behavior, A Review of Genetic Studies

    Science.gov (United States)

    Qayyum, Arqam; Zai, Clement C.; Hirata, Yuko; Tiwari, Arun K.; Cheema, Sheraz; Nowrouzi, Behdin; Beitchman, Joseph H.; Kennedy, James L.

    2015-01-01

    Aggressive behaviors have become a major public health problem, and early-onset aggression can lead to outcomes such as substance abuse, antisocial personality disorder among other issues. In recent years, there has been an increase in research in the molecular and genetic underpinnings of aggressive behavior, and one of the candidate genes codes for the catechol-O-methyltransferase (COMT). COMT is involved in catabolizing catecholamines such as dopamine. These neurotransmitters appear to be involved in regulating mood which can contribute to aggression. The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. We will be reviewing the current literature on this gene variant in aggressive behavior. PMID:26630958

  9. Energy dependence of transverse momentum fluctuations in Pb+Pb collisions at the CERN Super Proton Synchrotron (SPS) at 20A to 158A GeV

    CERN Document Server

    Anticic, T; Barna, D; Bartke, J; Betev, L; Bialkowska, H; Blume, C; Boimska, B; Botje, M; Bracinik, J; Buncic, P; Cerny, V; Christakoglou, P; Chung, P; Chvala, O; Cramer, J G; Csató, P; Dinkelaker, P; Eckardt, V; Fodor, Z; Foka, P; Friese, o V; Gál, J; Gazdzicki, M; Genchev, V; Gladysz-Dziadus, E; Grebieszkow, K; Hegyi, S; Höhne, C; Kadija, K; Karev, A; Kikola, D; Kolesnikov, V I; Kornas, E; Korus, R; Kowalski, M; Kreps, M; Laszlo, A; Lacey, R; Van Leeuwen, M; Lévai, Peter; Litov, L; Lungwitz, B; Makariev, M; Malakhov, A I; Mateev, M; Melkumov, G L; Mischke, A; Mitrovski, M; Molnár, J; Mrówczynski, S; Nicolic, V; Pálla, G; Panagiotou, A D; Panayotov, D; Petridis, A; Peryt, W; Pikna, M; Pluta, J; Prindle, D; Pühlhofer, F; Renfordt, R; Roland, C; Roland, G; Rybczynski, M; Rybicki, A; Sandoval, A; Schmitz, N; Schuster, T; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Slodkowski, M; Stefanek, G; Stock, R; Strabel, C; Ströbele, H; Susa, T; Szentpétery, I; Sziklai, J; Szuba, M; Szymanski, P; Trubnikov, V; Utvic, M; Varga, D; Vassiliou, M; Veres, G I; Vesztergombi, G; Vranic, D; Wlodarczyk, Z; Wojtaszek, A; Yoo, I K

    2009-01-01

    Results are presented on event-by-event fluctuations of transverse momenta $p_T$ in central Pb+Pb interactions at 20$A$, 30$A$, 40$A$, 80$A$ and 158$A$ GeV. The analysis was performed for charged particles at forward center-of-mass rapidity ($1.1 < y^{*}_{\\pi} < 2.6$). Three fluctuation measures were studied: the distribution of average transverse momentum ($M(p_T)$) in the event, the $\\Phi_{p_{T}}$ fluctuation measure and two-particle transverse momentum correlations. Fluctuations of $p_T$ are small and show no significant energy dependence in the SPS energy range. Results are compared with QCD-inspired predictions for the critical point, and with the UrQMD model.

  10. Measurements of the absolute photoionization cross section of Fe{sup +} ions from 15.8 to 180 eV

    Energy Technology Data Exchange (ETDEWEB)

    Kjeldsen, H. [Institute of Physics and Astronomy, University of Aarhus, Aarhus (Germany)]. E-mail: kjeldsen@ifa.au.dk; Kristensen, B.; Folkmann, F.; Andersen, T. [Institute of Physics and Astronomy, University of Aarhus, Aarhus (Germany)

    2002-09-14

    The absolute single-and double-photoionization cross sections of singly charged Fe ions have been measured from 15.8 to 180 eV using the merged-beam technique. The data yield information about the photoionization continua and the resonance structures resulting from excitation of the outer 3d and 4s electrons as well as the inner 3p and 3s electrons. The vast majority of the Fe{sup +} target ions were present in the ground-state configuration, 3d{sup 6}4s, and term,{sup 6}D. The experimental data have been compared with several calculations, for example R-matrix calculations from the Opacity Project and data obtained using the central-field approximations. The experimental data are available at http://www.iop.orgww.ifa.au.dk/amo/atomphys/atomphys.htm. (author)

  11. Pion Freeze-Out Time in Pb+Pb Collisions at 158 A GeV/c Studied via pi-/pi+ and K-/K+ Ratios

    CERN Document Server

    Aggarwal, M.M.; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bucher, D.; Busching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M.P.; Delagrange, H.; Donni, P.; Dutta Majumdar, M.R.; El Chenawi, K.; Dubey, A.K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Karadjev, K.; Karpio, K.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G.C.; Mohanty, B.; Mora, M.J.; Morrison, D.; Mukhanova, T.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Pavliouk, S.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Phatak, S.C.; Pinganaud, W.; Plasil, F.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; van de Pijll, E.C.; van Eijndhoven, N.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.; Voros, S.; Wyslouch, B.; Young, G.R.

    2006-01-01

    The effect of the final state Coulomb interaction on particles produced in Pb+Pb collisions at 158 A GeV/c has been investigated in the WA98 experiment through the study of the pi-/pi+ and K-/K+ ratios measured as a function of transverse mass. While the ratio for kaons shows no significant transverse mass dependence, the pi-/pi+ ratio is enhanced at small transverse mass values with an enhancement that increases with centrality. A silicon pad detector located near the target is used to estimate the contribution of hyperon decays to the pi-/pi+ ratio. The comparison of results with predictions of the RQMD model in which the Coulomb interaction has been incorporated allows to place constraints on the time of the pion freeze-out.

  12. Event-by-Event Fluctuations in Particle Multiplicities and Transverse Energy Produced in 158.A GeV Pb+Pb collisions

    CERN Document Server

    Aggarwal, M.M.; Ahammed, Z.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bucher, D.; Busching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M.P.; Delagrange, H.; Donni, P.; Dutta Majumdar, M.R.; El Chenawi, K.; Dubey, A.K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Karadjev, K.; Karpio, K.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G.C.; Mohanty, B.; Mora, M.J.; Morrison, D.; Mukhanova, T.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Phatak, S.C.; Pinganaud, W.; Plasil, F.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; van de Pijll, E.C.; van Eijndhoven, N.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.S.; Voros, S.; Wyslouch, B.; Young, G.R.

    2001-01-01

    Event-by-event fluctuations in the multiplicities of charged particles and photons, and the total transverse energy in 158$\\cdot A$ GeV Pb+Pb collisions are studied for a wide range of centralities. For narrow centrality bins the multiplicity and transverse energy distributions are found to be near perfect Gaussians. The effect of detector acceptance on the multiplicity fluctuations has been studied and demonstrated to follow statistical considerations. The centrality dependence of the charged particle multiplicity fluctuations in the measured data has been found to agree reasonably well with those obtained from a participant model. However for photons the multiplicity fluctuations has been found to be lower compared to those obtained from a participant model. The multiplicity and transverse energy fluctuations have also been compared to those obtained from the VENUS event generator.

  13. The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies.

    Science.gov (United States)

    Qayyum, Arqam; Zai, Clement C; Hirata, Yuko; Tiwari, Arun K; Cheema, Sheraz; Nowrouzi, Behdin; Beitchman, Joseph H; Kennedy, James L

    2015-01-01

    Aggressive behaviors have become a major public health problem, and early-onset aggression can lead to outcomes such as substance abuse, antisocial personality disorder among other issues. In recent years, there has been an increase in research in the molecular and genetic underpinnings of aggressive behavior, and one of the candidate genes codes for the catechol-O-methyltransferase (COMT). COMT is involved in catabolizing catecholamines such as dopamine. These neurotransmitters appear to be involved in regulating mood which can contribute to aggression. The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. We will be reviewing the current literature on this gene variant in aggressive behavior.

  14. Modification of the rho-meson detected by low-mass electron-positron pairs in central Pb-Au collisions at 158 A GeV/c

    CERN Document Server

    Adamová, D; Appelshäuser, H; Belaga, V; Bielcikova, J; Braun-munziger, P; Busch, O; Cherlin, A; Damjanovic, S; Dietel, T; Dietrich, L; Drees, A; Esumi, S I; Filimonov, K; Fomenko, K; Fraenkel, Zeev; Garabatos, C; Glssel, P; Holeczek, J; Kushpil, V; Ludolphs, a W; Maas, A; Marn, A; Miloevi, J; Milov, A; Mikowiec, D; Panebrattsev, iscs Yu; Petchenova, O; Petrek, V; Pfeiffer, A; Rak, J; Ravinovich, acI; Sako, H; Schmitz, W; Sedykh, S; Shimansky, S; Stachel, J; Sumbera, M; Tilsner, H; Tserruya, Itzhak; Wessels, J P; Wienold, T; Wurm, J P; Xie, W; Yurevich, S; Yurevich, V

    2008-01-01

    We present a measurement of $e^+e^-$ pair production in central Pb-Au collisions at 158$A$ GeV/$c$. As reported earlier, a significant excess of the $e^+e^-$ pair yield over the expectation from hadron decays is observed. The improved mass resolution of the present data set, recorded with the upgraded CERES experiment at the CERN-SPS, allows for a comparison of the data with different theoretical approaches. The data clearly favor a substantial in-medium broadening of the $\\rho$ spectral function over a density-dependent shift of the $\\rho$ pole mass at SPS energy. The in-medium broadening model implies that baryon induced interactions are the key mechanism to in-medium modifications of the $\\rho$-meson in the hot fireball.

  15. Fast neutrons from thick deuterium target irradiated by 15.8 MeV protons and 14.1 MeV deuterons

    CERN Document Server

    Bem, P; Cvachovec, F; Götz, M; Kroha, V; Nikolskii, E Y; Simeckova, E; Vincour, J

    1999-01-01

    The energy spectra of neutrons emitted by a thick deuterium target at 0 deg. angle, irradiated by a beam of 15.8 MeV protons and 14.1 MeV deuterons were measured in an open geometry with a stilbene scintillator and with a two-dimensional n-gamma discrimination technique. The evaluated spectral yields were compared with those of p+Be and d+Be reactions at relevant energies. This comparison shows that the D-target spectra are substantially harder having small relative contribution of low-energy neutrons, which makes these reactions useful as intense neutron sources for biomedical and analytical purposes. The total neutron yield from the d+D reaction is in good agreement with values calculated from published differential cross-section data. The p+D reaction seems to be the most effective fast neutron source, based on low-energy (E<40 MeV) cyclotrons.

  16. Production of $\\phi$ -mesons in p+p, p+Pb and central Pb+Pb collisions at $E_{beam}$=158 A GeV

    CERN Document Server

    Afanasiev, S V; Bächler, J; Barna, D; Barnby, L S; Bartke, Jerzy; Barton, R A; Betev, L; Bialkowska, H; Billmeier, A; Blume, C; Blyth, C O; Boimska, B; Bracinik, J; Brady, F P; Brun, R; Buncic, P; Carr, L; Cebra, D; Cooper, G E; Cramer, J G; Csató, P; Eckardt, V; Eckhardt, F; Ferenc, D; Fischer, H G; Fodor, Z; Foka, P Y; Freund, P; Friese, V; Ftácnik, J; Gál, J; Ganz, R E; Gazdzicki, M; Gladysz-Dziadus, E; Grebieszkow, J; Harris, J W; Hegyi, S; Hlinka, V; Höhne, C; Igo, G; Ivanov, M; Jacobs, P; Janik, R; Jones, P G; Kadija, K; Kolesnikov, V I; Kowalski, M; Lasiuk, B; Lévai, Peter; Malakhov, A I; Margetis, S; Markert, C; Mayes, B W; Melkumov, G L; Mischke, A; Molnár, J; Nelson, J M; Odyniec, Grazyna Janina; Oldenburg, M; Pálla, G; Panagiotou, A D; Petridis, A; Pikna, M; Pinsky, L; Poskanzer, A M; Prindle, D J; Pühlhofer, F; Reid, J G; Renfordt, R E; Retyk, W; Ritter, H G; Röhrich, D; Roland, C; Roland, G; Rybicki, A; Sammer, T; Sandoval, A; Sann, H; Semenov, A Yu; Schäfer, E; Schmitz, N; Seyboth, P; Siklér, F; Sitár, B; Skrzypczak, E; Snellings, R; Squier, G T A; Stock, Reinhard; Strmen, P; Ströbele, H; Susa, T; Szarka, I; Szentpétery, I; Sziklai, J; Toy, M; Trainor, T A; Trentalange, S; Ullrich, T S; Varga, D; Vassiliou, Maria; Veres, G I; Vesztergombi, G; Voloshin, S A; Vranic, D; Wang, F; Weerasundara, D D; Wenig, S; Whitten, C; Xu, N; Yates, T A; Yoo, I K; Zimányi, J

    2000-01-01

    Yields and phase space distributions of phi -mesons emitted from p+p (minimum bias trigger), p+Pb (at various centralities) and central Pb +Pb collisions are reported (E/sub beam/=158 A GeV). The decay phi to K/sup +/K/sup -/ was used for identification. The phi / pi ratio is found to increase by a factor of 3.0+or-0.7 from inelastic p+p to central Pb+Pb. Significant enhancement in this ratio is also observed in subclasses of p+p events (characterized by high charged-particle multiplicity) as well as in the forward hemisphere of central p+Pb collisions. In Pb+Pb no shift or significant broadening of the phi - peak is seen. (28 refs).

  17. COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndrome.

    LENUS (Irish Health Repository)

    Boot, Erik

    2011-09-01

    Although catechol-O-methyltransferase (COMT) activity evidently affects dopamine function in prefrontal cortex, the contribution is assumed less significant in striatum. We studied whether a functional polymorphism in the COMT gene (Val(158) Met) influences striatal D(2\\/3) R binding ratios (D(2\\/3) R BP(ND) ) in 15 adults with 22q11 deletion syndrome and hemizygous for this gene, using single photon emission computed tomography and the selective D(2\\/3) radioligand [(123) I]IBZM. Met hemizygotes had significantly lower mean D(2\\/3) R BPND than Val hemizygotes. These preliminary data suggest that low COMT activity may affect dopamine levels in striatum in humans and this may have implications for understanding the contribution of COMT activity to psychiatric disorders.

  18. Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms.

    Science.gov (United States)

    Zannas, Anthony S; McQuoid, Douglas R; Steffens, David C; Chrousos, George P; Taylor, Warren D

    2012-07-01

    Although the relation between stressful life events (SLEs) and risk of major depressive disorder is well established, important questions remain about the effects of stress on the course of geriatric depression. Our objectives were (1) to examine how baseline stress and change in stress is associated with course of geriatric depression and (2) to test whether polymorphisms of serotonin transporter (5-HTTLPR) and catechol-O-methyltransferase (COMT Val158Met) genes moderate this relation. Two-hundred and sixteen depressed subjects aged 60 years or older were categorized by remission status (Montgomery-Asberg depression rating scale≤6) at 6 and 12 months. At 6 months, greater baseline numbers of self-reported negative and total SLEs and greater baseline perceived stress severity were associated with lower odds of remission. At 12 months, only baseline perceived stress predicted remission. When we examined change in stress, 12-month decrease in negative SLEs and level of perceived stress were associated with improved odds of 12-month remission. When genotype data were included, COMT Val158Met genotype did not influence these relations. However, when compared with 5-HTTLPR L/L homozygotes, S allele carriers with greater baseline numbers of negative SLEs and with greater decrease in negative SLEs were more likely to remit at 12 months. This study demonstrates that baseline SLEs and perceived stress severity may influence the 12-month course of geriatric depression. Moreover, changes in these stress measures over time correlate with depression outcomes. 5-HTTLPR S carriers appear to be more susceptible to both the effects of enduring stress and the benefit of interval stress reduction.

  19. Bone-forming peptide-3 induces osteogenic differentiation of bone marrow stromal cells via regulation of the ERK1/2 and Smad1/5/8 pathways

    Directory of Open Access Journals (Sweden)

    Jun Sik Lee

    2018-01-01

    Full Text Available A bone-remodeling imbalance induced by increased bone resorption and osteoclast formation causes skeletal diseases such as osteoporosis. Induction of osteogenic differentiation of bone marrow stromal cells (BMSCs leads to bone regeneration. Many researchers have tried to develop new adjuvants as specific stimulators of bone regeneration for therapeutic use in patients with bone resorption. We tried to develop a new adjuvant that has stronger osteogenic differentiation-promoting activity than bone morphogenetic proteins (BMPs. In this study, we identified a new peptide, which we called bone-forming peptide (BFP-3, derived from the immature precursor of BMP-7. Upon osteogenic differentiation, BMSCs treated with BFP-3 exhibited higher alkaline phosphatase (ALP activity and mineralization ability and significantly up-regulated expression of osteogenic genes such as ALP, osteocalcin (OC, Osterix, and Runx2 compared with control BMSCs. Furthermore, fluorescence-activated cell sorting (FACS and immunofluorescence analyses demonstrated that BFP-3 treatment up-regulated CD44 expression. Interestingly, extracellular signal-regulated kinase 1/2 (ERK1/2 and Smad1/5/8 phosphorylation was increased by BFP-3 treatment during osteogenic differentiation. Furthermore, BFP-3-induced osteogenic differentiation was significantly decreased by treatment with ERK1/2- and Smad-specific inhibitors. These results suggest that BFP-3 plays an important role in regulating osteogenic differentiation of BMSCs through increasing levels of osteogenic-inducing factors and regulating the ERK1/2 and Smad1/5/8 signaling pathways. Our finding indicates that BFP-3 may be a potential new therapeutic target for promoting bone formation.

  20. The effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress.

    Science.gov (United States)

    Klaus, Kristel; Butler, Kevin; Durrant, Simon J; Ali, Manir; Inglehearn, Chris F; Hodgson, Timothy L; Gutierrez, Humberto; Pennington, Kyla

    2017-05-01

    Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. However, increasing evidence suggests environmental factors such as early life stress may interact with genetic variants in affecting these cognitive outcomes. This study investigated the effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress in healthy adults. One hundred and twenty-two healthy adult males (mean age 35.2 years, range 21-63) were enrolled in the study. Cognitive function was assessed using Cambridge Neuropsychological Test Automated Battery and early life stress was assessed using the Childhood Traumatic Events Scale (Pennebaker & Susman, 1988). DRD2 C957T was significantly associated with executive function, with CC homozygotes having significantly reduced performance in spatial working memory and spatial planning. A significant genotype-trauma interaction was found in Rapid Visual Information Processing test, a measure of sustained attention, with CC carriers who had experienced early life stress exhibiting impaired performance compared to the CC carriers without early life stressful experiences. There were no significant findings for COMT Val158Met. This study supports previous findings that DRD2 C957T significantly affects performance on executive function related tasks in healthy individuals and shows for the first time that some of these effects may be mediated through the impact of childhood traumatic events. Future work should aim to clarify further the effect of stress on neuronal systems that are known to be vulnerable in mental health disorders and more specifically what the impact of this might be on cognitive function.

  1. Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age.

    Science.gov (United States)

    Chau, Cecil M Y; Ranger, Manon; Sulistyoningrum, Dian; Devlin, Angela M; Oberlander, Tim F; Grunau, Ruth E

    2014-01-01

    Children born very preterm are exposed to repeated neonatal procedures that induce pain and stress during hospitalization in the neonatal intensive care unit (NICU). The COMT Val158Met genotype is involved with pain sensitivity, and early life stress is implicated in altered expression of methylation of the serotonin transporter. We examined: (1) whether methylation of the serotonin transporter gene (SLC6A4) promoter differs between very preterm children and full-term controls at school age, (2) relationships with child behavior problems, and (3) whether the extent of neonatal pain exposure interacts with the COMT Val158Met genotype to predict SLC6A4 methylation at 7 years in the very preterm children. We examined the associations between the COMT genotypes, neonatal pain exposure (adjusted for neonatal clinical confounders), SLC6A4 methylation and behavior problems. Very preterm children had significantly higher methylation at 7/10 CpG sites in the SLC6A4 promoter compared to full-term controls at 7 years. Neonatal pain (adjusted for clinical confounders) was significantly associated with total child behavior problems on the Child Behavior Checklist (CBCL) questionnaire (adjusted for concurrent stressors and 5HTTLPR genotype) (p = 0.035). CBCL Total Problems was significantly associated with greater SLC6A4 methylation in very preterm children (p = 0.01). Neonatal pain (adjusted for clinical confounders) and COMT Met/Met genotype were associated with SLC6A4 promoter methylation in very preterm children at 7 years (p = 0.001). These findings provide evidence that both genetic predisposition and early environment need to be considered in understanding susceptibility for developing behavioral problems in this vulnerable population.

  2. SWIFT REVEALS A ∼5.7 DAY SUPER-ORBITAL PERIOD IN THE M31 GLOBULAR CLUSTER X-RAY BINARY XB158

    Energy Technology Data Exchange (ETDEWEB)

    Barnard, R.; Garcia, M. R.; Murray, S. S. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

    2015-03-01

    The M31 globular cluster X-ray binary XB158 (a.k.a. Bo 158) exhibits intensity dips on a 2.78 hr period in some observations, but not others. The short period suggests a low mass ratio, and an asymmetric, precessing disk due to additional tidal torques from the donor star since the disk crosses the 3:1 resonance. Previous theoretical three-dimensional smoothed particle hydrodynamical modeling suggested a super-orbital disk precession period 29 ± 1 times the orbital period, i.e., ∼81 ± 3 hr. We conducted a Swift monitoring campaign of 30 observations over ∼1 month in order to search for evidence of such a super-orbital period. Fitting the 0.3-10 keV Swift X-Ray Telescope luminosity light curve with a sinusoid yielded a period of 5.65 ± 0.05 days, and a >5σ improvement in χ{sup 2} over the best fit constant intensity model. A Lomb-Scargle periodogram revealed that periods of 5.4-5.8 days were detected at a >3σ level, with a peak at 5.6 days. We consider this strong evidence for a 5.65 day super-orbital period, ∼70% longer than the predicted period. The 0.3-10 keV luminosity varied by a factor of ∼5, consistent with variations seen in long-term monitoring from Chandra. We conclude that other X-ray binaries exhibiting similar long-term behavior are likely to also be X-ray binaries with low mass ratios and super-orbital periods.

  3. Association of the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Anxiety-Related Traits: A Meta-Analysis

    Science.gov (United States)

    Lee, Lewina O.; Prescott, Carol A.

    2014-01-01

    Objectives The main goals of this study were: (i) to examine genotypic association of the COMT val158met polymorphism with anxiety-related traits via a meta-analysis; (ii) to examine sex and ethnicity as moderators of the association, and (iii) to evaluate whether the association differed by particular anxiety traits. Methods Association studies of the COMT val18met polymorphism and anxiety traits were identified from the PubMed or PsycInfo databases, conference abstracts and listserv postings. Exclusion criteria were: (a) pediatric samples, (b) exclusively clinical samples, and (c) samples selected for a non-anxiety phenotype. Standardized mean differences in anxiety between genotypes were aggregated to produce mean effect sizes across all available samples, and for subgroups stratified by sex and ethnicity (Caucasians vs. Asians). Construct-specific analysis was conducted to evaluate the association of COMT with neuroticism, harm avoidance, and behavioral inhibition. Results Twenty seven eligible studies (N=15,979) with available data were identified. Overall findings indicate sex-specific and ethnic-specific effects: Val homozygotes had higher neuroticism than Met homozygotes in studies of Caucasian males ( ES¯=0.13, 95%CI: 0.02 – 0.25, p = 0.03), and higher harm avoidance in studies of Asian males ( ES¯=0.43, 95%CI: 0.14 – 0.72, p = 0.004). No significant associations were found in women and effect sizes were diminished when studies were aggregated across ethnicity or anxiety traits. Conclusions: This meta-analysis provides evidence for sex and ethnicity differences in the association of the COMT val158met polymorphism with anxiety traits. Our findings contribute to current knowledge on the relation between prefrontal dopaminergic transmission and anxiety. PMID:24300663

  4. Catechol-O-methyltransferase Val158-Met polymorphism and a response of hyperactive-impulsive symptoms to methylphenidate: A replication study from South Korea.

    Science.gov (United States)

    Park, Subin; Kim, Jae-Won; Kim, Bung-Nyun; Shin, Min-Sup; Yoo, Hee-Jeong; Cho, Soo-Churl

    2014-07-01

    We investigated the association between the catechol-O-methyltransferase (COMT) Val(158)-Met (rs4680) genotype and both subjective and objective treatment responses to methylphenidate in Korean children with attention-deficit/hyperactivity disorder (ADHD). We enrolled 120 medication-naïve children with ADHD in an open-label, 8-week trial of methylphenidate. The participants were genotyped and evaluated using the Clinical Global Impression Scale and the ADHD Rating Scale-IV (ADHD-RS), and completed the Continuous Performance Test (CPT) before and after treatment. We found a significant association between the COMT Val/Val genotype and a good response, in terms of hyperactive-impulsive scores on the ADHD-RS (odds ratio (OR) = 2.61; p = 0.044) and response-time variability on the CPT (OR = 2.66; p = 0.028). The association of the COMT Val/Val genotype with a good response, in terms of response time variability, was significant in both the sub-sample of combined-type (OR = 3.45; p = 0.026) and sub-sample of inattentive-type (OR = 5.52; p = 0.029); but the association with a good response in terms of hyperactive-impulsive scores was not significant in sub-sample analyses. Although the reported nominally significant associations did not stay significant after correcting for multiple testing, our results support previous findings about the possible involvement of the COMT (Val(158)-Met) polymorphism in the treatment response to methylphenidate in children with ADHD. © The Author(s) 2014.

  5. Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4 promoter methylation in very preterm children at school age

    Directory of Open Access Journals (Sweden)

    Cecil Ming Yeung Chau

    2014-12-01

    Full Text Available Children born very preterm are exposed to repeated neonatal procedures that induce pain and stress during hospitalization in the neonatal intensive care unit (NICU. The COMT Val158Met genotype is involved with pain sensitivity, and early life stress is implicated in altered expression of methylation of the serotonin transporter. We examined: (1 whether methylation of the serotonin transporter gene (SLC6A4 promoter differs between very preterm children and full-term controls at school age, (2 relationships with child behavior problems, and (3 whether the extent of neonatal pain exposure interacts with the COMT Val158Met genotype to predict SLC6A4 methylation at 7 years in the very preterm children. We examined the associations between the COMT genotypes, neonatal pain exposure (adjusted for neonatal clinical confounders, SLC6A4 methylation and behavior problems. Very preterm children had significantly higher methylation at 7/10 CpG sites in the SLC6A4 promoter compared to full-term controls at 7 years. Neonatal pain (adjusted for clinical confounders was significantly associated with total child behaviour problems on the Child Behavior Checklist (CBCL questionnaire (adjusted for concurrent stressors and 5HTTLPR genotype (p = 0.035. CBCL total problems was significantly associated with greater SLC6A4 methylation in very preterm children (p = 0.01. Neonatal pain (adjusted for clinical confounders and COMT Met/Met genotype were associated with SLC6A4 promoter methylation in very preterm children at 7 years (p = 0.001. These findings provide evidence that both genetic predisposition and early environment need to be considered in understanding susceptibility for developing behavioral problems in this vulnerable population.

  6. Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.

    Directory of Open Access Journals (Sweden)

    Sari Voutilainen

    2007-01-01

    Full Text Available The role of circulating levels of total homocysteine tHcy in the development of coronary heart disease (CHD is still under debate. One reason for conflicting results between previous studies on homocysteine and heart diseases could be consequence of different interactions between homocysteine and genes in different study populations. Many genetic factors play a role in folate-homocysteine metabolism, like functional polymorphism (Val108Met in the Catechol-O-methyltransferase (COMT gene.Our aim was to examine the role of COMT Val158Met polymorphism and interaction of this polymorphism with serum tHcy and folate concentration on the risk of acute coronary and events in middle-aged men from eastern Finland. A population-based prospective cohort of 792 men aged 46-64 years was examined as part of the Kuopio Ischaemic Heart Disease Risk Factor Study. During an average follow-up of 9.3 years, there were 69 acute coronary events in men with no previous history of CHD. When comparing the COMT low activity genotype with the others, we found an age and examination year adjusted hazard rate ratio (HRR of 1.73 (95% confidence interval (CI, 1.07-2.79, and an age, examination year, serum LDL and HDL cholesterol, and triglyceride concentration, systolic blood pressure and smoking adjusted HRR of 1.77 (95% CI, 1.05-2.77. Although serum tHcy concentration was not statistically significantly associated with acute coronary events (HRR for the highest third versus others 1.52, 95% CI, 0.93-2.49, subjects with both high serum tHcy and the COMT low activity genotype had an additionally increased adjusted risk of HRR 2.94 (95% CI 1.50-5.76 as compared with other men.This prospective cohort study suggests that the functional COMT Val158Met polymorphism is associated with increased risk of acute coronary events and it may interact with high serum tHcy levels.

  7. Catechol-O-methyltransferase Val158Met polymorphism is associated with increased risk of multiple uterine leiomyomas either positive or negative for MED12 exon 2 mutations.

    Science.gov (United States)

    Dzhemlikhanova, Lyailya Kh; Efimova, Olga A; Osinovskaya, Natalia S; Parfenyev, Sergey E; Niauri, Dariko A; Sultanov, Iskender Yu; Malysheva, Olga V; Pendina, Anna A; Shved, Natalia Yu; Ivashchenko, Tatyana E; Yarmolinskaya, Maria I; Kakhiani, Maka I; Gorovaya, Ekaterina A; Tkachenko, Antonina N; Baranov, Vladislav S

    2017-03-01

    To study the possible association of catechol-O-methyltransferase (COMT) Val158Met polymorphism with multiple and solitary uterine leiomyomas (ULs) and to check whether the COMT Val/Val genotype is associated with MED12 exon 2 mutations in fibroids. The COMT Val158Met allele and genotype frequencies were compared between age-matched women with ULs (n=104) and controls (n=59). Patients with UL were subcategorised by diagnosis of solitary (n=59) or multiple (n=45) fibroids and by the presence of somatic MED12 exon 2 mutations in at least one fibroid (n=32) or in neither fibroid (n=26). The association of COMT Val/Val genotype with the presence of any ULs, solitary/multiple ULs and ULs positive/negative for MED12 exon 2 mutations was evaluated by χ2 tests using a dominant genotype model (G/G vs G/A+A/A) and expressed as ORs and 95% CIs. The COMT Val/Val genotype frequency did not differ between the patients with UL and the controls (28.8% vs 18.6%, p=0.149, OR 1.77; CI 0.81 to 3.86). However, it was significantly higher in the patients who had multiple UL compared with the solitary UL (40% vs 20.3%, p=0.028, OR 2.61; CI 1.09 to 6.24) and to the controls (40% vs 18.6%, p=0.016, OR 2.91; CI 1.20 to 7.06). No association of the COMT Val/Val genotype with UL-specific MED12 exon 2 mutations was found (p=0.662, OR 0.77; CI 0.23 to 2.53). Women with COMT Val/Val genotype are at high risk of developing multiple uterine fibroids either positive or negative for MED12 exon 2 mutations. These data are important to design new strategies for UL prophylaxis and treatment. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  8. Genetic diversity of Histoplasma and Sporothrix complexes based on sequences of their ITS1-5.8S-ITS2 regions from the BOLD System.

    Science.gov (United States)

    Estrada-Bárcenas, Daniel Alfonso; Vite-Garín, Tania; Navarro-Barranco, Hortensia; de la Torre-Arciniega, Raúl; Pérez-Mejía, Amelia; Rodríguez-Arellanes, Gabriela; Ramirez, Jose Antonio; Humberto Sahaza, Jorge; Taylor, Maria Lucia; Toriello, Conchita

    2014-01-01

    High sensitivity and specificity of molecular biology techniques have proven usefulness for the detection, identification and typing of different pathogens. The ITS (Internal Transcribed Spacer) regions of the ribosomal DNA are highly conserved non-coding regions, and have been widely used in different studies including the determination of the genetic diversity of human fungal pathogens. This article wants to contribute to the understanding of the intra- and interspecific genetic diversity of isolates of the Histoplasma capsulatum and Sporothrix schenckii species complexes by an analysis of the available sequences of the ITS regions from different sequence databases. ITS1-5.8S-ITS2 sequences of each fungus, either deposited in GenBank, or from our research groups (registered in the Fungi Barcode of Life Database), were analyzed using the maximum likelihood (ML) method. ML analysis of the ITS sequences discriminated isolates from distant geographic origins and particular wild hosts, depending on the fungal species analyzed. This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012). Copyright © 2013 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

  9. Event by Event Analysis of High Multiplicity Events Produced in 158 A GeV/c 208 Pb- 208 Pb Collisions

    CERN Document Server

    Ahmad, Shakeel; Kumar, Ashwini; Chaturvedi, O S K; Ahmad, A; Zafar, M; Irfan, M; Singh, B K

    2015-01-01

    An extensive analysis of individual high multiplicity events produced in 158 A GeV /c 208Pb- 208Pb collisions is carried by adopting different methods to examine the anomalous behavior of these rare events. A method of selecting the events with densely populated narrow regions or spikes out of a given sample of collision events is discussed.Employing this approach two events with large spikes in their eta- and phi- distributions are selected for further analysis. For the sake of comparison, another two events which do not exhibit such spikes are simultaneously analyzed. The findings suggest that the systematic studies of particle density fluctuations in one- and two-dimensional phase-spaces and comparison with those obtained from the studies of correlation free Monte Carlo events, would be useful for identifying the events with large dynamical fluctuations. Formation of clusters or jet like phenomena in multihadronic final states in individual events is also discussed and the experimental findings are compare...

  10. Strangelet search and particle production studies in Pb-Pb collisions at 158·A GeV/c with the H6 beamline spectrometer at CERN

    CERN Document Server

    Lindén, Tomas

    The charged particle beamline simulation program DECAY TURTLE (Trace Unlimited Rays Through Lumped Elements) has been modified to enable simulation of dipole magnet steering effects and simulation of hadronic interactions. These modifications together with the implementation of the measured misalignments of the magnetic elements of the H6 beamline at the CERN North Area and implementation of more accurate magnet apertures have been shown to allow a realistic simulation to be made of the complex 524 m long H6 beamline spectrometer used by NA52. The acceptance of the H6 beamline spectrometer has been computed using this modified version of DECAY TURTLE. Using these results better determined invariant differential production cross sections have been computed from the NA52 1994-1995 data, with improved error estimates. New limits for strangelet production in lead-lead collisions at 158.A GeV/c have been computed from the NA52 measurements from 1994-1995. The methods and results presented in this work can be appli...

  11. Native Top-Down ESI-MS of 158 kDa Protein Complex by High Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    Science.gov (United States)

    Li, Huilin; Wolff, Jeremy J.; Van Orden, Steve L.; Loo, Joseph A.

    2014-01-01

    Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) delivers high resolving power, mass measurement accuracy, and the capabilities for unambiguously sequencing by a top-down MS approach. Here, we report isotopic resolution of a 158 kDa protein complex - tetrameric aldolase with an average absolute deviation of 0.36 ppm and an average resolving power of ~520,000 at m/z 6033 for the 26+ charge state in magnitude mode. Phase correction further improves the resolving power and average absolute deviation by 1.3 fold. Furthermore, native top-down electron capture dissociation (ECD) enables the sequencing of 149 C-terminal amino acid (AA) residues out of 463 total AAs. Combining the data from top-down MS of native and denatured aldolase complexes, a total of 58% of the backbone cleavages efficiency is achieved. The observation of complementary product ion pairs confirms the correctness of the sequence and also the accuracy of the mass fitting of the isotopic distribution of the aldolase tetramer. Top-down MS of the native protein provides complementary sequence information to top-down ECD and CAD MS of the denatured protein. Moreover, native top-down ECD of aldolase tetramer reveals that ECD fragmentation is not limited only to the flexible regions of protein complexes and that regions located on the surface topology are prone to ECD cleavage. PMID:24313806

  12. Preliminary results from the 2000 run of CERES on low-mass $e^{+}e^{-}}$ pair production in Pb-Au collisions at 158 A GeV

    CERN Document Server

    Cherlin, A

    2004-01-01

    CERES has measured low-mass e/sup positive /sup negative pairs in Pb- Au collisions at 158 A GeV in the year 2000 Pb run at the SPS with the goal of shedding more light on the origin of the previously observed low-mass pair enhancement. The spectrometer was upgraded with a radial TPC to improve the mass resolution. A very effective rejection of the combinatorial background is achieved using the combined information of the two RICH detectors, the dE/dx signal of the doublet of silicon drift chambers, and the TPC track dE/dx information. Various steps and the current status of the data analysis are presented. Corrigendum. Table 1 and figures 3 and 4, as originally published, represent an earlier version of the data analysis. The corrected table and figures have been published as a Corrigendum (see below). The Corrigendum has also been appended at the end of the PDF file linked to this page.

  13. The effects of the COMT Val108/158Met polymorphism on BOLD activation during working memory, planning, and response inhibition: a role for the posterior cingulate cortex?

    Science.gov (United States)

    Stokes, Paul R A; Rhodes, Rebecca A; Grasby, Paul M; Mehta, Mitul A

    2011-03-01

    Catechol-O-methyl transferase (COMT) val(108/158)met polymorphism impacts on cortical dopamine levels and may influence functional magnetic resonance (fMRI) measures of task-related neuronal activity. Here, we investigate whether COMT genotype influences cortical activations, particularly prefrontal activations, by interrogating its effect across three tasks that have been associated with the dopaminergic system in a large cohort of healthy volunteers. A total of 50 participants (13 met/met, 23 val/met, and 14 val/val) successfully completed N-Back, Go-NoGo, and Tower of London fMRI tasks. Image analysis was performed using statistical parametric mapping. No significant relationships between COMT genotype groups and frontal lobe activations were observed for any contrast of the three tasks studied. However, the val/val group produced significantly greater deactivation of the right posterior cingulate cortex in two tasks: the Go-NoGo (NoGo vs Go deactivation contrast) and N-Back (2-back vs rest deactivation contrast). For the N-Back task, the modulated deactivation cluster was functionally connected to the precuneus, left middle occipital lobe, and cerebellum. These results do not support findings of prefrontal cortical modulation of activity with COMT genotype, but instead suggest that COMT val/val genotype can modulate the activity of the posterior cingulate and may indicate the potential network effects of COMT genotype on the default mode network.

  14. Source radii at target rapidity from two-proton and two-deuteron correlations in central Pb+Pb collisions at 158 A GeV

    CERN Document Server

    Aggarwal, M M; Angelis, A.L.S.; Antonenko, V.; Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Awes, T.C.; Baba, P.V.K.S.; Badyal, S.K.; Bathe, S.; Batiounia, B.; Bernier, T.; Bhalla, K.B.; Bhatia, V.S.; Blume, C.; Bucher, D.; Busching, H.; Carlen, L.; Chattopadhyay, S.; Decowski, M.P.; Delagrange, H.; Donni, P.; Dutta Majumdar, M.R.; El Chenawi, K.; Dubey, A.K.; Enosawa, K.; Fokin, S.; Frolov, V.; Ganti, M.S.; Garpman, S.; Gavrishchuk, O.; Geurts, F.J.M.; Ghosh, T.K.; Glasow, R.; Guskov, B.; Gustafsson, H.A.; Gutbrod, H.H.; Hrivnacova, I.; Ippolitov, M.; Kalechofsky, H.; Kamermans, R.; Karadjev, K.; Karpio, K.; Kolb, B.W.; Kosarev, I.; Koutcheryaev, I.; Kugler, A.; Kulinich, P.; Kurata, M.; Lebedev, A.; Liu, H.; Lohner, H.; Luquin, L.; Mahapatra, D.P.; Manko, V.; Martin, M.; Martinez, G.; Maximov, A.; Miake, Y.; Mishra, G.C.; Mohanty, B.; Mora, M.-J.; Morrison, D.; Moukhanova, T.; Mukhopadhyay, D.S.; Naef, H.; Nandi, B.K.; Nayak, S.K.; Nayak, T.K.; Nianine, A.; Nikitine, V.; Nikolaev, S.; Nilsson, P.; Nishimura, S.; Nomokonov, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Pavliouk, S.; Peitzmann, T.; Peressounko, D.; Petracek, V.; Petracek, V.; Pinanaud, W.; Plasil, F.; Purschke, M.L.; Rak, J.; Raniwala, R.; Raniwala, S.; Rao, N.K.; Retiere, F.; Reygers, K.; Roland, G.; Rosselet, L.; Roufanov, I.; Roy, C.; Rubio, J.M.; Sambyal, S.S.; Santo, R.; Sato, S.; Schlagheck, H.; Schmidt, H.-R.; Schutz, Y.; Shabratova, G.; Shah, T.H.; Sibiriak, I.; Siemiarczuk, T.; Silvermyr, D.; Sinha, B.C.; Slavine, N.; Soderstrom, K.; Sood, G.; Sorensen, S.P.; Stankus, P.; Stefanek, G.; Steinberg, P.; Stenlund, E.; Sumbera, M.; Svensson, T.; Tsvetkov, A.; Tykarski, L.; van de Pijll, E.C.; van Eijndhoven, N.; van Nieuwenhuizen, G.J.; Vinogradov, A.; Viyogi, Y.P.; Vodopianov, A.; Voros, S.; Wyslouch, B.; Young, G.R.

    2007-01-01

    Two-proton and two-deuteron correlations have been studied in the target fragmentation region of central Pb+Pb collisions at 158 A GeV. Protons and deuterons were measured with the Plastic Ball spectrometer of the WA98 experiment at the CERN SPS. The results of one-dimensional and multi-dimensional analyses using both the Bertsch-Pratt and Yano-Koonin-Podgoretsky parameterizations of the two-particle correlation functions are presented. The proton source exhibits a volume emission, while the deuteron source, with small outward radius, appears opaque. Both proton and deuteron sources have cross-terms R_{ol}^2 and longitudinal velocities beta consistent with zero, indicating a boost-invariant expansion. The invariant radius parameter R follows an approximate A/sqrt{m} scaling while the longitudinal and transverse radii, R_{L} and R_{T}, scale approximately as A/sqrt{m_{T}} with A ~ 3 fm GeV^{1/2} in both cases.

  15. Kaon and pion production in centrality selected minimum bias Pb+Pb collisions at 40 and 158A.GeV

    CERN Document Server

    Dinkelaker, Peter

    2009-01-01

    Results on charged kaon and negatively charged pion production and spectra for centrality selected Pb+Pb mininimum bias events at 40 and 158A GeV have been presented in this thesis. All analysis are based on data taken by the NA49 experiment at the accelerator Super Proton Synchrotron (SPS) at the European Organization for Nuclear Research (CERN) in Geneva, Switzerland. The kaon results are based on an analysis of the mean energy loss of the charged particles traversing the detector gas of the time projection chambers (TPCs). The pion results are from an analysis of all negatively charged particles h- corrected for contributions from particle decays and secondary interactions. For the dE/dx analysis of charged kaons, main TPC tracks with a total momentum between 4 and 50 GeV have been analyzed in logarithmic momentum log(p) and transverse momentum pt bins. The resulting dE/dx spectra have been fitted by the sum of 5 Gaussians, one for each main particle type (electrons, pions, kaons, pro...

  16. Measurement of negatively charged pion spectra in inelastic p+p interactions at p{sub lab} = 20, 31, 40, 80 and 158 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Abgrall, N.; Blondel, A.; Bravar, A.; Debieux, S.; Haesler, A.; Korzenev, A.; Murphy, S.; Ravonel, M. [University of Geneva, Geneva (Switzerland); Aduszkiewicz, A.; Dominik, W.; Kielczewska, D.; Kirejczyk, M.; Matulewicz, T.; Posiadala, M.; Skrzypczak, E. [University of Warsaw, Faculty of Physics, Warsaw (Poland); Ali, Y.; Brzychczyk, J.; Majka, Z.; Marcinek, A.; Planeta, R.; Staszel, P.; Wyszynski, O. [Jagiellonian University, Cracow (Poland); Anticic, T.; Kadija, K.; Susa, T. [Rudjer Boskovic Institute, Zagreb (Croatia); Antoniou, N.; Christakoglou, P.; Davis, N.; Diakonos, F.; Kapoyannis, A.; Panagiotou, A.D.; Vassiliou, M. [University of Athens, Athens (Greece); Baatar, B.; Bunyatov, S.A.; Kolesnikov, V.I.; Krasnoperov, A.; Lyubushkin, V.V.; Malakhov, A.I.; Melkumov, G.L.; Tereshchenko, V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Bay, F.; Luise, S.Di; Rubbia, A.; Sgalaberna, D. [ETH, Zurich (Switzerland); Blumer, J.; Dembinski, H.; Engel, R.; Mathes, H.J.; Roth, M.; Szuba, M.; Ulrich, R.; Unger, M. [Karlsruhe Institute of Technology, Karlsruhe (Germany); Bogomilov, M.; Kolev, D.; Tsenov, R. [University of Sofia, Faculty of Physics, Sofia (Bulgaria); Busygina, O.; Golubeva, M.; Guber, F.; Ivashkin, A.; Kurepin, A.; Marin, V.; Petukhov, O.; Sadovsky, A. [Institute for Nuclear Research, Moscow (Russian Federation); Czopowicz, T.; Dynowski, K.; Grebieszkow, K.; Maksiak, B.; Peryt, W.; Pluta, J.; Slodkowski, M. [Warsaw University of Technology, Warsaw (Poland); Drozhzhova, T.; Feofilov, G.A.; Igolkin, S.; Kondratiev, V.P.; Vechernin, V.V.; Vinogradov, L. [St. Petersburg State University, St. Petersburg (Russian Federation); Dumarchez, J.; Robert, A.; Zambelli, L. [LPNHE, University of Paris VI and VII, Paris (France); Ereditato, A.; Hierholzer, M.; Nirkko, M.; Pistillo, C.; Redij, A. [University of Bern, Bern (Switzerland); Fodor, Z.; Fulop, A.; Kiss, T.; Laszlo, A.; Marton, K.; Palla, G.; Sipos, R.; Tolyhi, T.; Vesztergombi, G. [KFKI Research Institute for Particle and Nuclear Physics, Budapest (Hungary); Gazdzicki, M. [Jan Kochanowski University in Kielce, Kielce (Poland); University of Frankfurt, Frankfurt (Germany); Grzeszczuk, A.; Kaptur, E.; Kisiel, J.; Kowalski, S.; Larsen, D.; Pulawski, S.; Schmidt, K.; Wilczek, A.; Zipper, W. [University of Silesia, Katowice (Poland); Hasegawa, T.; Kobayashi, T.; Nakadaira, T.; Nishikawa, K.; Sakashita, K.; Sekiguchi, T.; Shibata, M.; Tada, M. [High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki (Japan); Idczak, R.; Kovesarki, P.; Turko, L. [University of Wroclaw, Wroclaw (Poland); Jokovic, D.; Manic, D.; Puzovic, J.; Savic, M. [University of Belgrade, Belgrade (Serbia); Kleinfelder, S. [University of California, Irvine (United States); Mackowiak-Pawlowska, M.; Renfordt, R.; Rustamov, A.; Stroebele, H. [University of Frankfurt, Frankfurt (Germany); Matveev, V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Institute for Nuclear Research, Moscow (Russian Federation); Mrowczynski, S.; Rybczynski, M.; Seyboth, P.; Stefanek, G.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A. [Jan Kochanowski University in Kielce, Kielce (Poland); Palczewski, T.; Rondio, E.; Stepaniak, J. [National Centre for Nuclear Research, Warsaw (Poland); Paul, T.; Veberic, D. [University Nova Gorica, Laboratory of Astroparticle Physics, Nova Gorica (Slovenia); Popov, B.A. [Joint Institute for Nuclear Research, Dubna (Russian Federation); LPNHE, University of Paris VI and VII, Paris (France); Rauch, W. [Fachhochschule Frankfurt, Frankfurt (Germany); Roehrich, D. [University of Bergen, Bergen (Norway); Collaboration: NA61/SHINE Collaboration

    2014-03-15

    We present experimental results on inclusive spectra and mean multiplicities of negatively charged pions produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158 GeV/c (√(s) = 6.3, 7.7, 8.8, 12.3 and 17.3 GeV, respectively). The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN super proton synchrotron. Two-dimensional spectra are determined in terms of rapidity and transverse momentum. Their properties such as the width of rapidity distributions and the inverse slope parameter of transverse mass spectra are extracted and their collision energy dependences are presented. The results on inelastic p+p interactions are compared with the corresponding data on central Pb+Pb collisions measured by the NA49 experiment at the CERN SPS. The results presented in this paper are part of the NA61/SHINE ion program devoted to the study of the properties of the onset of deconfinement and search for the critical point of strongly interacting matter. They are required for interpretation of results on nucleus-nucleus and proton-nucleus collisions. (orig.)

  17. Measurement of negatively charged pion spectra in inelastic p+p interactions at $p_{lab}$ = 20, 31, 40, 80 and 158 GeV/c

    CERN Document Server

    Abgrall, N; Ali, Y; Anticic, T; Antoniou, N; Baatar, B; Bay, F; Blondel, A; Blumer, J; Bogomilov, M; Bravar, A; Brzychczyk, J; Bunyatov, S A; Busygina, O; Christakoglou, P; Czopowicz, T; Davis, N; Debieux, S; Dembinski, H; Diakonos, F; Di Luise, S; Dominik, W; Drozhzhova, T; Dumarchez, J; Dynowski, K; Engel, R; Ereditato, A; Feofilov, G A; Fodor, Z; Fulop, A; Gazdzicki, M; Golubeva, M; Grebieszkow, K; Grzeszczuk, A; Guber, F; Haesler, A; Hasegawa, T; Hierholzer, M; Idczak, R; Igolkin, S; Ivashkin, A; Jokovic, D; Kadija, K; Kapoyannis, A; Katrynska, N; Kaptur, E; Kielczewska, D; Kirejczyk, M; Kisiel, J; Kiss, T; Kleinfelder, S; Kobayashi, T; Kolesnikov, V I; Kolev, D; Kondratiev, V P; Korzenev, A; Kovesarki, P; Kowalski, S; Krasnoperov, A; Kurepin, A; Larsen, D; Laszlo, A; Lyubushkin, V V; Mackowiak-Pawlowska, M; Majka, Z; Maksiak, B; Malakhov, A I; Manic, D; Marcinek, A; Marin, V; Marton, K; Mathes, H J; Matulewicz, T; Matveev, V; Melkumov, G.L; Mrowczynski, St; Murphy, S; Nakadaira, T; Nirkko, M; Nishikawa, K; Palczewski, T; Palla, G; Panagiotou, A D; Paul, T; Pistillo, C; Peryt, W; Petukhov, O; Planeta, R; Pluta, J; Popov, B A; Posiadala, M; Pulawski, S; Puzovic, J; Rauch, W; Ravonel, M; Redij, A; Renfordt, R; Robert, A; Rohrich, D; Rondio, E; Roth, M; Rubbia, A; Rustamov, A; Rybczynski, M; Sadovsky, A; Sakashita, K; Savic, M; Schmidt, K; Sekiguchi, T; Seyboth, P; Sgalaberna, D; Shibata, M; Sipos, R; Skrzypczak, E; Slodkowski, M; Staszel, P; Stefanek, G; Stepaniak, J; Strobele, H; Susa, T; Szuba, M; Tada, M; Tereshchenko, V; Tolyhi, T; Tsenov, R; Turko, L; Ulrich, R; Unger, M; Vassiliou, M; Veberic, D; Vechernin, V V; Vesztergombi, G; Vinogradov, L; Wilczek, A; Wlodarczyk, Z; Wojtaszek-Szwarc, A; Wyszynski, O; Zambelli, L; Zipper, W

    2014-01-01

    We present experimental results on inclusive spectra and mean multiplicities of negatively charged pions produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158GeV/c ($\\sqrt{s}$ = 6.3, 7.7, 8.8, 12.3 and 17.3GeV, respectively). The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN super proton synchrotron. Two-dimensional spectra are determined in terms of rapidity and transverse momentum. Their properties such as the width of rapidity distributions and the inverse slope parameter of transverse mass spectra are extracted and their collision energy dependences are presented. The results on inelastic p+p interactions are compared with the corresponding data on central Pb+Pb collisions measured by the NA49 experiment at the CERN SPS. The results presented in this paper are part of the NA61/SHINE ion program devoted to the study of the properties of the onset of deconfinement and search for the critical point of strongly inter...

  18. Inclusive production of protons, anti-protons, neutrons, deuterons and tritons in p+C collisions at 158 GeV/c beam momentum

    CERN Document Server

    Baatar, B.; Bartke, J.; Betev, L.; Chvala, O.; Dolejsi, J.; Eckardt, V.; Fischer, H.G.; Fodor, Z.; Karev, A.; Kolesnikov, V.; Kowalski, M.; Makariev, M.; Malakhov, A.; Mateev, M.; Melkumov, G.; Rybicki, A.; Schmitz, N.; Seyboth, P.; Stock, R.; Tinti, G.; Varga, D.; Vesztergombi, G.; Wenig, S.

    2013-04-09

    The production of protons, anti-protons, neutrons, deuterons and tritons in minimum bias p+C interactions is studied using a sample of 385 734 inelastic events obtained with the NA49 detector at the CERN SPS at 158 GeV/c beam momentum. The data cover a phase space area ranging from 0 to 1.9 GeV/c in transverse momentum and in Feynman x from -0.80 to 0.95 for protons, from -0.2 to 0.4 for anti-protons and from 0.2 to 0.95 for neutrons. Existing data in the far backward hemisphere are used to extend the coverage for protons and light nuclear fragments into the region of intranuclear cascading. The use of corresponding data sets obtained in hadron-proton collisions with the same detector allows for the detailed analysis and model-independent separation of the three principle components of hadronization in p+C interactions, namely projectile fragmentation, target fragmentation of participant nucleons and intranuclear cascading.

  19. Variation in phytoplankton composition between two North Pacific frontal zones along 158°W during winter-spring 2008-2011

    Science.gov (United States)

    Howell, Evan A.; Bograd, Steven J.; Hoover, Aimee L.; Seki, Michael P.; Polovina, Jeffrey J.

    2017-01-01

    Data from three research cruises along the 158°W meridian through the North Pacific Subtropical Frontal Zone (STF) during spring 2008, 2009, and 2011 were used to estimate phytoplankton functional types and size classes. These groups were used to describe phytoplankton composition at the North Pacific Subtropical (STF) and Transition Zone Chlorophyll (TZCF) Fronts, which represent ecologically important large-scale features in the central North Pacific. Phytoplankton class composition was consistent at each front through time, yet significantly different between fronts. The STF contained lower integrated chlorophyll-a concentrations, with surface waters dominated by picophytoplankton and a deep chlorophyll maximum equally comprised of pico- and nanophytoplankton. The TZCF contained significantly higher concentrations of nanophytoplankton through the water column, specifically the prymnesiophyte group. Integrated chlorophyll-a concentrations at the TZCF were 30-90% higher than at the STF, with the dominant increase in the signal from the nanophytoplanktonic prymnesiophyte group. The meridional position of the STF was consistently located near 32°N through these three years, with the more spatially variable TZCF ranging from 2° to 4° further north of the STF. This variability in the frontal position of the TZCF may lead to ecological impacts though the food web. Continued in-situ and remote monitoring, specifically during El Niño and ENSO neutral phases, will provide additional ecological information to help understand mechanistic causes of phytoplankton variability in this important ecological region.

  20. The catechol-o-methyltransferase Val158 Met polymorphism modulates organization of regional cerebral blood flow response to working memory in adults.

    Science.gov (United States)

    Heim, Alicia F; Coyne, Melissa J; Kamboh, M Ilyas; Ryan, Christopher; Jennings, J Richard

    2013-11-01

    This study examined the effect of catechol-o-methyltransferase (COMT) Val(158)Met genotypes on the co-activation of brain areas involved in cognition during a working memory (WM) task. The pattern of concomitant region of interest (ROI) activation during WM performance varied by genotype: Val/Val showing the least and Met/Met the most covariance. There were no differences of performance on the WM task between the COMT genotypes. However, relatively better performance was associated with less concomitance of dorsolateral prefrontal cortex (DLPFC) and cingulate cortex for Val/Val, but more concomitance of DLPFC with AH for Met/Met. Within genotypes WM performance was significantly correlated with rCBF to the amygdala/hippocampus (AH) for Val/Val (r = 0.44, p = 0.009), to the parietal lobe for Val/Met (r = 0.29, p = 0.03), and to the thalamus for Met/Met (r = 0.32, p = 0.04). Different genotypes showed different regional specificity and concomitant activation patterns suggesting that varying dopamine availability induces different brain processing pathways to achieve similar WM performance. © 2013.

  1. Age-Dependent Effects of Catechol-O-Methyltransferase (COMT) Gene Val158Met Polymorphism on Language Function in Developing Children.

    Science.gov (United States)

    Sugiura, Lisa; Toyota, Tomoko; Matsuba-Kurita, Hiroko; Iwayama, Yoshimi; Mazuka, Reiko; Yoshikawa, Takeo; Hagiwara, Hiroko

    2017-01-01

    The genetic basis controlling language development remains elusive. Previous studies of the catechol-O-methyltransferase (COMT) Val158Met genotype and cognition have focused on prefrontally guided executive functions involving dopamine. However, COMT may further influence posterior cortical regions implicated in language perception. We investigated whether COMT influences language ability and cortical language processing involving the posterior language regions in 246 children aged 6-10 years. We assessed language ability using a language test and cortical responses recorded during language processing using a word repetition task and functional near-infrared spectroscopy. The COMT genotype had significant effects on language performance and processing. Importantly, Met carriers outperformed Val homozygotes in language ability during the early elementary school years (6-8 years), whereas Val homozygotes exhibited significant language development during the later elementary school years. Both genotype groups exhibited equal language performance at approximately 10 years of age. Val homozygotes exhibited significantly less cortical activation compared with Met carriers during word processing, particularly at older ages. These findings regarding dopamine transmission efficacy may be explained by a hypothetical inverted U-shaped curve. Our findings indicate that the effects of the COMT genotype on language ability and cortical language processing may change in a narrow age window of 6-10 years. © The Author 2016. Published by Oxford University Press.

  2. Strangeness enhancement at midrapidity in Pb-Pb collisions at 158 A GeV/c: a comparison with VENUS and RQMD models

    Energy Technology Data Exchange (ETDEWEB)

    Antinori, F. [Padua Univ. (Italy). Dipt. di Fisica; Bakke, H.; Beusch, W. [and others

    1999-11-01

    Recently the WA97 Collaboration has measured K{sup 0}{sub S}, {lambda}, {xi}, {omega} and negative particle yields and transverse mass spectra at central rapidity in Pb-Pb and p-Pb collisions at 158 A GeV/c. These results are compared with the predictions of two of the most widely used event generators for heavy-ion collisions: VENUS 4.12 and RQMD 2.3. Both models predict that enhancements increase with the strangeness content of the particle. They fail, however, to reproduce completely the measured values of yields at central rapidity. In particular, for multistrange particles, VENUS fails to reproduce both the p-Pb and the Pb-Pb data, while RQMD works for p-Pb collisions but seems to be unable to reproduce the {omega} data in Pb-Pb collisions. Moreover, the predicted behavior for strangeness production as a function of the centrality of the collision appears to be different from the observed behavior. (orig.)

  3. 153 - 158_Jacob_Antibacterial

    African Journals Online (AJOL)

    pc

    al., 2013). Traditional uses of medicinal plants ha witnessed gradual directional change leading to m complex and advanced modern drugs. Seve modifications, improvement, sophistication and new discoveries have continuously contributed to t quality, presentation and concept of medici preparation (Sathish et al., 2013).

  4. Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.

    Science.gov (United States)

    Zarrouk, Amira; Nury, Thomas; Karym, El-Mostafa; Vejux, Anne; Sghaier, Randa; Gondcaille, Catherine; Andreoletti, Pierre; Trompier, Doriane; Savary, Stéphane; Cherkaoui-Malki, Mustapha; Debbabi, Meryam; Fromont, Agnès; Riedinger, Jean-Marc; Moreau, Thibault; Lizard, Gérard

    2017-05-01

    Mitochondrial dysfunctions and oxidative stress are involved in several non demyelinating or demyelinating neurodegenerative diseases. Some of them, including multiple sclerosis (MS), are associated with lipid peroxidation processes leading to increased levels of 7-ketocholesterol (7KC). So, the eventual protective effect of dimethylfumarate (DMF), which is used for the treatment of MS, was evaluated on 7KC-treated oligodendrocytes, which are myelin synthesizing cells. To this end, murine oligodendrocytes 158N were exposed to 7KC (25, 50μM) for 24h without or with DMF (1, 25, 50μM). The biological activities of DMF associated or not with 7KC were evaluated by phase contrast microscopy, crystal violet and MTT tests. The impact on transmembrane mitochondrial potential (ΔYm), O 2 - and H 2 O 2 production, apoptosis and autophagy was measured by microscopical and flow cytometric methods by staining with DiOC 6 (3), dihydroethidine and dihydrorhodamine 123, Hoechst 33342, and by Western blotting with the use of specific antibodies raised against uncleaved and cleaved caspase-3 and PARP, and LC3-I/II. DMF attenuates the different effects of 7KC, namely: cell growth inhibition and/or loss of cell adhesion, decrease of ΔΨm, O 2 - and H 2 O 2 overproduction, PARP and caspase-3 cleavage, nuclear condensation and fragmentation, and activation of LC3-I into LC3-II. The ability of DMF to attenuate 7KC-induced reactive oxygen species overproduction, apoptosis, and autophagy on oligodendrocytes reinforces the interest for this molecule for the treatment of MS or other demyelinating diseases. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Immediate reward bias in humans: fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype.

    Science.gov (United States)

    Boettiger, Charlotte A; Mitchell, Jennifer M; Tavares, Venessa C; Robertson, Margaret; Joslyn, Geoff; D'Esposito, Mark; Fields, Howard L

    2007-12-26

    The tendency to choose lesser immediate benefits over greater long-term benefits characterizes alcoholism and other addictive disorders. However, despite its medical and socioeconomic importance, little is known about its neurobiological mechanisms. Brain regions that are activated when deciding between immediate or delayed rewards have been identified (McClure et al., 2004, 2007), as have areas in which responses to reward stimuli predict a paper-and-pencil measure of temporal discounting (Hariri et al., 2006). These studies assume "hot" and "cool" response selection systems, with the hot system proposed to generate impulsive choices in the presence of a proximate reward. However, to date, brain regions in which the magnitude of activity during decision making reliably predicts intertemporal choice behavior have not been identified. Here we address this question in sober alcoholics and non-substance-abusing control subjects and show that immediate reward bias directly scales with the magnitude of functional magnetic resonance imaging bold oxygen level-dependent (BOLD) signal during decision making at sites within the posterior parietal cortex (PPC), dorsal prefrontal cortex (dPFC), and rostral parahippocampal gyrus regions. Conversely, the tendency of an individual to wait for a larger, delayed reward correlates directly with BOLD signal in the lateral orbitofrontal cortex. In addition, genotype at the Val158Met polymorphism of the catechol-O-methyltransferase gene predicts both impulsive choice behavior and activity levels in the dPFC and PPC during decision making. These genotype effects remained significant after controlling for alcohol abuse history. These results shed new light on the neurobiological underpinnings of temporal discounting behavior and identify novel behavioral and neural consequences of genetic variation in dopamine metabolism.

  6. COMT Val158Met genotype selectively alters prefrontal [18F]fallypride displacement and subjective feelings of stress in response to a psychosocial stress challenge.

    Directory of Open Access Journals (Sweden)

    Dennis Hernaus

    Full Text Available Catechol-O-methyltransferase (COMT plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. We aimed to investigate the effect of variations in COMT genotype on in vivo measures of stress-induced prefrontal cortex (PFC dopaminergic processing and subjective stress responses. A combined sample of healthy controls and healthy first-degree relatives of psychosis patients (n = 26 were subjected to an [(18F]fallypride Positron Emission Tomography scan. Psychosocial stress during the scan was induced using the Montreal Imaging Stress Task and subjective stress was assessed every 12 minutes. Parametric t-maps, generated using the linear extension of the simplified reference region model, revealed an effect of COMT genotype on the spatial extent of [(18F]fallypride displacement. Detected effects of exposure to psychosocial stress were unilateral and remained restricted to the left superior and right inferior frontal gyrus, with Met-hetero- and homozygotes showing less [(18F]fallypride displacement than Val-homozygotes. Additionally, Met-hetero- and homozygotes experienced larger subjective stress responses than Val-homozygotes. The direction of the effects remained the same when the data was analyzed separately for controls and first-degree relatives. The human stress response may be mediated in part by COMT-dependent dopaminergic PFC activity, providing speculation for the neurobiology underlying COMT-dependent differences in human behaviour following stress. Implications of these results for stress-related psychopathology and models of dopaminergic functioning are discussed.

  7. Effect of catechol-O-methyltransferase-val158met-polymorphism on the automatization of motor skills - a post hoc view on an experimental data.

    Science.gov (United States)

    Krause, Daniel; Beck, Frieder; Agethen, Manfred; Blischke, Klaus

    2014-06-01

    The purpose of this study was to evaluate if the catechol-O-methyltransferase-val158met (COMT)-polymorphism, which is known to affect prefrontal dopaminergic metabolism, affects the automatization of motor skills. Twenty-two participants volunteered for gene analysis after they had participated in experiments in which they practiced a single-joint arm movement sequence 460-760 times under different feedback conditions. Motor automaticity was assessed in a pre-test and a post-test according to the dual-task paradigm, which incorporated a visuo-spatial secondary task. To account for the different practice conditions in the four original studies, dual-task cost reduction was assessed using single case effect sizes proportioned to the respective group mean. For the secondary task but not for the prioritized motor task, these relative single case effect sizes proved to be positively (and significantly) correlated with the number of met-alleles on the COMT-genotype, rs=.553; p=.004. Thus, the number of met-alleles indicated a tendency toward enhanced motor automatization. Thus, due to an increased prefrontal dopamine level, met-carriers may be able to develop a well formed and stable, spatially coded movement representation early in practice, thereby supporting the formation of a representation in motor coordinates in the course of extended practice, which later enables automatic movement execution. This process might also be enhanced by a prevalence of met-carriers to functionally evaluate positive feedback information (i.e., rewards) and to better maintain recent reward information in active working memory. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions

    Directory of Open Access Journals (Sweden)

    Winnie W Leung

    2007-01-01

    Full Text Available Winnie W Leung1, Margaret M McClure1, Larry J Siever1,2, Deanna M Barch3, Philip D Harvey1,21Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center (MIRECC, Bronx, NY, USA; 2Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA; 3Departments of Psychology and Psychiatry, Washington University, St. Louis, MO, USAAbstract: A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT, an enzyme responsible for the degradation of the catecholamine dopamine (DA, epinephrine, and norepinephrine, is associated with cognitive deficits. However, previous studies have not examined the effects of COMT on context processing, as measured by the AX-CPT, a task hypothesized to be maximally relevant to DA function. 32 individuals who were either healthy, with schizotypal personality disorder, or non-cluster A, personality disorder (OPD were genotyped at the COMT Val158Met locus. Met/Met (n = 6, Val/Met (n = 10, Val/Val (n = 16 individuals were administered a neuropsychological battery, including the AX-CPT and the N-back working memory test. For the AX-CPT, Met/Met demonstrated more AY errors (reflecting good maintenance of context than the other genotypes, who showed equivalent error rates. Val/Val demonstrated disproportionately greater deterioration with increased task difficulty from 0-back to 1-back working memory demands as compared to Met/Met, while Val/Met did not differ from either genotypes. No differences were found on processing speed or verbal working memory. Both context processing and working memory appear related to COMT genotype and the AX-CPT and N-back may be most sensitive to the effects of COMT variation.Keywords: COMT, dopamine, context processing, working memory, schizotypal personality disorder

  9. Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.

    Science.gov (United States)

    Pertegal, Miriam; Fenoy, Francisco J; Hernández, Moisés; Mendiola, Jaime; Delgado, Juan L; Bonacasa, Bárbara; Corno, Andrés; López, Bernardo; Bosch, Vicente; Hernández, Isabel

    2016-01-01

    To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. Prospective case-control study. University hospital. A total of 53 preeclamptic and 72 normal pregnant women. Maternal and cord blood samples and placental tissue samples were obtained. Maternal and fetal COMT and MTHFR polymorphisms were genotyped. Maternal plasma 2-ME and homocysteine levels, and expression and activity of placental COMT were measured. The odds ratio for the risk of preeclampsia for fetal COMT Met/Met was 3.22, and it increased to 8.65 when associated with fetal MTHFR TT. Placental COMT activity and expression were influenced by genotype, but COMT activity in preeclamptic placentas did not differ from control pregnancies. There was no association between any genotypes and maternal 2-ME. Homocysteine levels were higher in women with preeclampsia than in normal pregnancies, and were inversely correlated with 2-ME plasma levels, indicating that its altered metabolism may lower COMT activity in vivo. Fetal Met-Met COMT genotype reduces COMT placental expression and activity in vitro and increases preeclampsia, risk but it does not explain the difference in maternal 2-ME levels between preeclamptic and normal pregnancies. However, the preeclamptic patients had elevated homocysteine levels that correlated inversely with 2-ME, indicating that an altered methionine-homocysteine metabolism may contribute to reduce COMT activity in vivo and explain the decreased levels of 2-ME in preeclamptic women. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  10. Association of COMT val158met and DRD2 G>T genetic polymorphisms with individual differences in motor learning and performance in female young adults.

    Science.gov (United States)

    Noohi, Fatemeh; Boyden, Nate B; Kwak, Youngbin; Humfleet, Jennifer; Burke, David T; Müller, Martijn L T M; Bohnen, Nico I; Seidler, Rachael D

    2014-02-01

    Individuals learn new skills at different rates. Given the involvement of corticostriatal pathways in some types of learning, variations in dopaminergic transmission may contribute to these individual differences. Genetic polymorphisms of the catechol-O-methyltransferase (COMT) enzyme and dopamine receptor D2 (DRD2) genes partially determine cortical and striatal dopamine availability, respectively. Individuals who are homozygous for the COMT methionine (met) allele show reduced cortical COMT enzymatic activity, resulting in increased dopamine levels in the prefrontal cortex as opposed to individuals who are carriers of the valine (val) allele. DRD2 G-allele homozygotes benefit from a higher striatal dopamine level compared with T-allele carriers. We hypothesized that individuals who are homozygous for COMT met and DRD2 G alleles would show higher rates of motor learning. Seventy-two young healthy females (20 ± 1.9 yr) performed a sensorimotor adaptation task and a motor sequence learning task. A nonparametric mixed model ANOVA revealed that the COMT val-val group demonstrated poorer performance in the sequence learning task compared with the met-met group and showed a learning deficit in the visuomotor adaptation task compared with both met-met and val-met groups. The DRD2 TT group showed poorer performance in the sequence learning task compared with the GT group, but there was no difference between DRD2 genotype groups in adaptation rate. Although these results did not entirely come out as one might predict based on the known contribution of corticostriatal pathways to motor sequence learning, they support the role of genetic polymorphisms of COMT val158met (rs4680) and DRD2 G>T (rs 1076560) in explaining individual differences in motor performance and motor learning, dependent on task type.

  11. Use of drugs for ADHD among adults-a multinational study among 15.8 million adults in the Nordic countries.

    Science.gov (United States)

    Karlstad, Øystein; Zoëga, Helga; Furu, Kari; Bahmanyar, Shahram; Martikainen, Jaana E; Kieler, Helle; Pottegård, Anton

    2016-12-01

    The use of ADHD drugs among adults is controversial and has until recently not been approved for use in adults in most countries. The aim was to investigate use of ADHD drugs (stimulants and atomoxetine) among the entire adult population in the Nordic countries. We conducted a multinational population-based prescription register study based on the entire adult population in the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden). All users of ADHD drugs aged 18-64 years during 2008-2012 were included, which for 2012 comprised 76,896 drug users among 15.8 million adult inhabitants. Annual prevalence of drug use increased during the study period for both genders and all age groups. The overall prevalence increased from 2.4 to 5.3 per 1000 men and 1.8 to 4.4 per 1000 women. Incidence also increased, but to a lesser extent in the last part of the study period. Methylphenidate was used by 88 % of drug users. Treatment was discontinued within the first year by 21 % of new drug users. Among all users of ADHD drugs, 53 % of men and 64 % of women concurrently used other psychotropic drugs, most frequently antidepressants and hypnotics. Psychotropic co-medication increased with age and was more pronounced among women than men. Use of ADHD drug among adults more than doubled over a 5-year period, and a majority were concurrently treated with other psychotropics. Adults constitute a substantial proportion of persons treated with ADHD drugs. Thus, evidence for long-term efficacy and safety in adults is urgently needed.

  12. System-size dependence of $\\Lambda$ and $\\Xi$ production in nucleus-nucleus collisions at 40A and 158A GeV measured at the CERN Super Proton Synchrotron

    CERN Document Server

    Anticic, T.; Barna, D.; Bartke, J.; Beck, H.; Betev, L.; Bialkowska, H.; Blume, C.; Boimska, B.; Book, J.; Botje, M.; Bracinik, J.; Buncic, P.; Cerny, V.; Christakoglou, P.; Chung, P.; Chvala, O.; Cramer, J.G.; Csato, P.; Dinkelaker, P.; Eckardt, V.; Fodor, Z.; Foka, P.; Friese, V.; Gal, J.; Gazdzicki, M.; Genchev, V.; Gladysz, E.; Grebieszkow, K.; Hegyi, S.; Hohne, C.; Kadija, K.; Karev, A.; Kresan, D.; Kolesnikov, V.I.; Kowalski, M.; Kraus, I.; Kreps, M.; Laszlo, A.; Lacey, R.; van Leeuwen, M.; Levai, P.; Litov, L.; Lungwitz, B.; Makariev, M.; Malakhov, A.I.; Mateev, M.; Melkumov, G.L.; Meurer, C.; Mischke, A.; Mitrovski, M.; Molnar, J.; Mrowczynski, St.; Nicolic, V.; Palla, G.; Panagiotou, A.D.; Panayotov, D.; Petridis, A.; Peryt, W.; Pikna, M.; Pluta, J.; Prindle, D.; Puhlhofer, F.; Renfordt, R.; Roland, C.; Roland, G.; Rybczynski, M.; Rybicki, A.; Sandoval, A.; Schmitz, N.; Schuster, T.; Seyboth, P.; Sikler, F.; Sitar, B.; Skrzypczak, E.; Slodkowski, M.; Stefanek, G.; Stock, R.; Strabel, C.; Strobele, H.; Susa, T.; Szentpetery, I.; Sziklai, J.; Szuba, M.; Szymanski, P.; Utvic, M.; Varga, D.; Vassiliou, M.; Veres, G.I.; Vesztergombi, G.; Vranic, D.; Wlodarczyk, Z.; Wojtaszek, A.; Yoo, I.K.

    2009-01-01

    Results on Lambda, Anti-lambda, and Xi- production in centrality selected Pb+Pb reactions at 40A and 158A GeV and in near-central C+C and Si+Si reactions at 158A GeV are presented. Transverse mass spectra, rapidity spectra, and multiplicities in dependence of the system size are discussed. Comparisons to transport models (UrQMD2.3 and HSD) and to the core-corona approach are performed. While Lambda and Anti-lambda production can be described by transport models reasonably well, these models do not agree with the Xi- measurements. On the other hand, the core-corona picture fits very well the system-size dependence of Lambda and Xi-, while it agrees less well with the Anti-lambda data. Absorption effects might play a role in case of Anti-lambda production.

  13. Comments concerning the paper ”Measurement of negatively charged pion spectra in inelastic p+p interactions at 20, 31, 40, 80 and 158 GeV/c” by the NA61 collaboration

    CERN Document Server

    Fischer, H G; Varga, D; Wenig, S

    2014-01-01

    New data from the NA61 collaboration on the production of negative pions in p+p interactions at beam momenta between 20 and 158 GeV/c are critically compared to available results in the same energy range. It is concluded that the NA61 data do not come up to the quality of the existing work. This concerns in particular the total yields, the pT integrated rapidity distributions and the double differential cross sections.

  14. Retraction notice to: Influence of external disturbances to dynamic balance of the semi-anthropomimetic robot [Serb. Jour. of elect. Eng., Vol. 11, no. 1, feb. 2014, pp. 145-158

    Directory of Open Access Journals (Sweden)

    Editorial

    2016-01-01

    Full Text Available Due to technical errors the article entitled „Influence of External Disturbances to Dynamic Balance of the Semi-Anthropomimetic Robot“, by authors Vladimir M. Petrović, Kosta Jovanović, Veljko Potkonjak, published in Serbian journal of Electrical Engineering, Vol. 11, No. 1, February 2014, pp. 145-158, has been retracted from the Journal. Link to the retracted article 10.2298/SJEE131014013P

  15. The Catechol-O-methyltransferase Val(108/158)Met Genetic Polymorphism cannot be Recommended as a Biomarker for the Prediction of Venlafaxine Efficacy in Patients Treated in Psychiatric Settings.

    Science.gov (United States)

    Taranu, Adela; Asmar, Khalil El; Colle, Romain; Ferreri, Florian; Polosan, Mircea; David, Denis; Becquemont, Laurent; Corruble, Emmanuelle; Verstuyft, Céline

    2017-11-01

    The antidepressant venlafaxine is known to increase the turnover of cerebral monoamines, which are catabolized by the catechol-O-methyltransferase (COMT). The COMT (Val(108/158)Met, rs4680) genetic polymorphism affects the cerebral COMT activity. But whether this genetic polymorphism is associated with response to venlafaxine remains unclear. We assessed the impact of the COMT Val(108/158)Met, rs4680 genetic polymorphism on the efficacy of venlafaxine in depressed patients. This study was nested in the METADAP cohort, a real-world naturalistic treatment study in psychiatric settings. A total of 206 Caucasian patients with a unipolar major depressive episode (DSM-IVTR) treated with venlafaxine and evaluated with the Hamilton Depression Rating Scale (HDRS) were studied. One hundred and eighty patients were genotyped for the COMT Val(108/158)Met, rs4680 genetic polymorphism and classified into three genotype subgroups: Val/Val, Val/Met and Met/Met. The COMT genotype was the explanatory variable, and the variables to be explained were HDRS score, HDRS score improvement over time, response rate and remission rate. Venlafaxine had a trend to higher efficacy in the Val/Val patients as compared to Met/Met carriers, as shown by the HDRS score improvement after 3 months of treatment, but this result was not significant in mixed models [Val/Val: 59.78% (±22.4); Val/Met: 51.64% (±26.3); Met/Met: 39.52% (±27.6)]. The percentage of responders and remitters after 3 months of treatment was not significantly different in the three genotype groups, although coherent trends were shown. The COMT Val(108/158)Met, rs4680 genetic polymorphism cannot be recommended as a biomarker for the prediction of venlafaxine efficacy in patients treated in psychiatric settings. © 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

  16. Allelic Polymorphism Determines Surface Expression or Intracellular Retention of the Human NK Cell Receptor KIR2DL5A (CD158f)

    Science.gov (United States)

    Cisneros, Elisa; Estefanía, Ernesto; Vilches, Carlos

    2017-01-01

    KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA. Unlike KIR2DL1–3, recognizing HLA-C allotypes through Ig-like domains of the D1–D2 type, KIR2DL5 shares a D0–D2 configuration with KIR2DL4, and its ligands have not been identified. KIR2DL5 is encoded by two paralogous genes displaying copy number variation and allelic polymorphism—KIR2DL5A and KIR2DL5B. UP-R1 mAb, raised against the common allele KIR2DL5A*001, enables specific KIR2DL5 detection. However, not every KIR2DL5+ individual has NK cells staining with UP-R1, discrepancy explained in part by epigenetically silent KIR2DL5B alleles with a distinctive substitution in a promoter RUNX-binding site. Furthermore, we show here that the transcribed allele KIR2DL5A*005, second most common of its locus, fails to confer NK cells UP-R1 reactivity, phenotype explained by inefficacious transport of its product to the cell surface. Two amino acid substitutions distinguish the KIR2DL5A*005 and *001 coding regions. Western blot, flow cytometry, and confocal microscopy analyses of cells transfected with tagged constructs demonstrate that a serine substitution for glycine-174, conserved in most KIR, is mainly responsible for KIR2DL5A*005 intracellular retention, and it also affects mAb recognition. In contrast, substitution of aspartate for asparagine 152 has only a minor effect on surface expression, despite destroying an otherwise conserved N-glycosylation site. Our results help to explain the variable expression profile of KIR2DL5+ subjects and indicate that functional polymorphisms in both its promoter and its coding regions are critical for understanding the KIR2DL5 role in immunity and its importance for human health. PMID:28144240

  17. Kaon and pion production in centrality selected minimum bias Pb+Pb collisions at 40 and 158 A.GeV

    Energy Technology Data Exchange (ETDEWEB)

    Dinkelaker, Peter

    2009-07-01

    Results on charged kaon and negatively charged pion production and spectra for centrality selected Pb+Pb minimum bias events at 40 and 158A GeV have been presented in this thesis. All analysis are based on data taken by the NA49 experiment at the accelerator Super Proton Synchrotron (SPS) at the European Organization for Nuclear Research (CERN) in Geneva, Switzerland. The kaon results are based on an analysis of the mean energy loss of the charged particles traversing the detector gas of the time projection chambers (TPCs). The pion results are from an analysis of all negatively charged particles h{sup -} corrected for contributions from particle decays and secondary interactions. For the dE/dx analysis of charged kaons, main TPC tracks with a total momentum between 4 and 50 GeV have been analyzed in logarithmic momentum log(p) and transverse momentum p{sub t} bins. The resulting dE/dx spectra have been fitted by the sum of 5 Gaussians, one for each main particle type (electrons, pions, kaons, protons, deuterons). The amplitude of the Gaussian used for the kaon part of the spectra has been corrected for efficiency and acceptance and the binning has been transformed to rapidity y and transverse momentum pt bins. The multiplicity dN/dy of the single rapidity bins has been derived by summing the measured range of the transverse momentum spectra and an extrapolation to full coverage with a single exponential function fitted to the measured range. The results have been combined with the mid-rapidity measurements from the time-of-flight detectors and a double Gaussian fit to the dN/dy spectra has been used for extrapolation to rapidity outside of the acceptance of the dE/dx analysis. For the h{sup -} analysis of negatively charged pions, all negatively charged tracks have been analyzed. The background from secondary reactions, particle decays, and gamma-conversions has been corrected with the VENUS event generator. The results were also corrected for efficiency

  18. Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin–angiotensin–aldosterone system inhibitors involving 158 998 patients

    Science.gov (United States)

    van Vark, Laura C.; Bertrand, Michel; Akkerhuis, K. Martijn; Brugts, Jasper J.; Fox, Kim; Mourad, Jean-Jacques; Boersma, Eric

    2012-01-01

    Aims Renin–angiotensin–aldosterone system (RAAS) inhibitors are well established for the reduction in cardiovascular morbidity, but their impact on all-cause mortality in hypertensive patients is uncertain. Our objective was to analyse the effects of RAAS inhibitors as a class of drugs, as well as of angiotensin-converting enzyme (ACE) inhibitors and AT1 receptor blockers (ARBs) separately, on all-cause mortality. Methods and results We performed a pooled analysis of 20 cardiovascular morbidity–mortality trials. In each trial at least two-thirds of the patients had to be diagnosed with hypertension, according to the trial-specific definition, and randomized to treatment with an RAAS inhibitor or control treatment. The cohort included 158 998 patients (71 401 RAAS inhibitor; 87 597 control). The incidence of all-cause death was 20.9 and 23.3 per 1000 patient-years in patients randomized to RAAS inhibition and controls, respectively. Overall, RAAS inhibition was associated with a 5% reduction in all-cause mortality (HR: 0.95, 95% CI: 0.91–1.00, P= 0.032), and a 7% reduction in cardiovascular mortality (HR: 0.93, 95% CI: 0.88–0.99, P= 0.018). The observed treatment effect resulted entirely from the class of ACE inhibitors, which were associated with a significant 10% reduction in all-cause mortality (HR: 0.90, 95% CI: 0.84–0.97, P= 0.004), whereas no mortality reduction could be demonstrated with ARB treatment (HR: 0.99, 95% CI: 0.94–1.04, P= 0.683). This difference in treatment effect between ACE inhibitors and ARBs on all-cause mortality was statistically significant (P-value for heterogeneity 0.036). Conclusion In patients with hypertension, treatment with an ACE inhibitor results in a significant further reduction in all-cause mortality. Because of the high prevalence of hypertension, the widespread use of ACE inhibitors may result in an important gain in lives saved. PMID:22511654

  19. Cross sections of production of J / {psi}, {psi}` resonances and of the Drell-Yan process in the Pb-Pb interactions with 158 GeV / c per nucleon; Section efficaces de production des resonances J / {psi}, {psi}` et du processus Drell-Yan dans les interactions Pb-Pb a 158 GeV / c par nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Bellaiche, F

    1997-04-24

    In the framework of the experimental research for the quark and gluons plasma formation in ultrarelativistic heavy ion collisions, data obtained by the NA50 collaboration at SPS-CERN are analysed. The segmented target used by NA50 experiment is described and analysed in terms of vertex identification efficiency and re-interactions recognition. The absolute J/{psi}, {psi}`and Drell-Yan process cross-sections in 158 GeV/c per nucleon Pb-Pb interactions are extracted. The transverse energy dependence of the production yield of J/{psi} and Drell-Yan process is established. The comparison of these cross-sections with the ones measured in lighter systems and the comparison of the E dependence of J/{psi} production with the Glauber model prediction show an anomalous J/{psi} suppression observed in Pb-Pb interactions is confronted to theoretical models proposed by several authors, describing charmonium bound states formation and interactions is confronted to theoretical models proposed by several authors, describing charmonium bound states formation and interactions in confined or deconfined media. (author) 122 refs.

  20. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from time series observations using Bubble type equilibrator for autonomous carbon dioxide (CO2) measurement, Carbon dioxide (CO2) gas analyzer and other instruments from MOORING MOSEAN_158W_23N in the North Pacific Ocean from 2004-12-19 to 2007-07-30 (NODC Accession 0100073)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0100073 includes chemical, meteorological, physical and time series data collected from MOORING MOSEAN_158W_23N in the North Pacific Ocean from...

  1. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from time series observations using Bubble type equilibrator for autonomous carbon dioxide (CO2) measurement, Carbon dioxide (CO2) gas analyzer and other instruments from MOORING CRIMP1_158W_21N in the North Pacific Ocean from 2005-12-01 to 2008-05-30 (NODC Accession 0100069)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0100069 includes chemical, meteorological, physical and time series data collected from MOORING CRIMP1_158W_21N in the North Pacific Ocean from...

  2. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from time series observations using Bubble type equilibrator for autonomous carbon dioxide (CO2) measurement, Carbon dioxide (CO2) gas analyzer and other instruments from MOORING_KILO_NALU_158W_21N in the North Pacific Ocean from 2008-06-07 to 2015-01-21 (NCEI Accession 0157251)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0157251 includes chemical, meteorological, physical and time series data collected from MOORING_KILO_NALU_158W_21N in the North Pacific Ocean from...

  3. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from time series observations using Bubble type equilibrator for autonomous carbon dioxide (CO2) measurement, Carbon dioxide (CO2) gas analyzer and other instruments from MOORING WHOTS_158W_23N in the North Pacific Ocean from 2007-06-26 to 2015-07-15 (NODC Accession 0100080)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0100080 includes chemical, meteorological, physical and time series data collected from WHOTS_158W_23N in the North Pacific Ocean from 2007-06-26 to...

  4. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from time series observations using Bubble type equilibrator for autonomous carbon dioxide (CO2) measurement, Carbon dioxide (CO2) gas analyzer and other instruments from MOORING_ALAWAI_158W_21N in the North Pacific Ocean from 2008-06-06 to 2014-07-28 (NCEI Accession 0157360)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0157360 includes chemical, meteorological, physical and time series data collected from MOORING_ALAWAI_158W_21N in the North Pacific Ocean from...

  5. White matter alterations related to attention-deficit hyperactivity disorder and COMT val158met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus)

    Science.gov (United States)

    Kabukcu Basay, Burge; Buber, Ahmet; Basay, Omer; Alacam, Huseyin; Ozturk, Onder; Suren, Serkan; Izci Ay, Ozlem; Acikel, Cengizhan; Agladıoglu, Kadir; Erdal, Mehmet Emin; Ercan, Eyup Sabri; Herken, Hasan

    2016-01-01

    Introduction In this article, the COMT gene val158met polymorphism and attention-deficit hyperactivity disorder (ADHD)-related differences in diffusion-tensor-imaging-measured white matter (WM) structure in children with ADHD and controls were investigated. Patients and methods A total of 71 children diagnosed with ADHD and 24 controls aged 8–15 years were recruited. Using diffusion tensor imaging, COMT polymorphism and ADHD-related WM alterations were investigated, and any interaction effect between the COMT polymorphism and ADHD was also examined. The effects of age, sex, and estimated total IQ were controlled by multivariate analysis of covariance (MANCOVA). Results First, an interaction between the COMT val158met polymorphism and ADHD in the right (R) cingulum (cingulate gyrus) (CGC) was found. According to this, valine (val) homozygote ADHD-diagnosed children had significantly lower fractional anisotropy (FA) and higher radial diffusivity (RD) in the R-CGC than ADHD-diagnosed methionine (met) carriers, and val homozygote controls had higher FA and lower RD in the R-CGC than val homozygote ADHD patients. Second, met carriers had higher FA and axial diffusivity in the left (L)-uncinate fasciculus and lower RD in the L-posterior corona radiata and L-posterior thalamic radiation (include optic radiation) than the val homozygotes, independent of ADHD diagnosis. Third, children with ADHD had lower FA in the L-CGC and R-retrolenticular part of the internal capsule than the controls, independent of the COMT polymorphism. Conclusion Significant differences reported here may be evidence that the COMT gene val158met polymorphism variants, as well as ADHD, could affect brain development. ADHD and the COMT polymorphism might be interactively affecting WM development in the R-CGC to alter the WM connectivity in children with val homozygote ADHD. PMID:27143897

  6. Legal content of the International Convention on the Protection of the Rights of All Migrant Workers and Members of Their Families, adopted by the united nations general assembly by resolution 45/158 of 18 December 1990.

    Directory of Open Access Journals (Sweden)

    Aurelia Álvarez Rodríguez

    2016-10-01

    Full Text Available The author makes a detailed analysis of the legal contents of the International Convention on the Protection of the Rights of all Migrant workers and their Families, adopted by the General Assembly of the United Nations in the Resolution 45/158 of December 1990. The objectives of the Convention, the personal spehere of application, the Human Rights of all migrant workers and their families wether they be regular of iregular are presented throughout the article. Finally, the practical effectiveness of the Convention is analyzed concluding with the importance of its ratification by the largest number of States possible.

  7. Freeze-Out Parameters in Central 158A GeV P[number sign]208 b+Pb Collision80s

    Energy Technology Data Exchange (ETDEWEB)

    Aggarwal, M.M.; Bhatia, V.S. (University of Panjab, Chandigarh 160014 (India)); Agnihotri, A.; Bhalla, K.B.; Gupta, S.K.; Raniwala, R.; Raniwala, S. (University of Rajasthan, Jaipur 302004, Rajasthan (India)); Ahammed, Z.; Chattopadhyay, S.; Das, A.C.; Dutta Majumdar, M.R.; Ganti, M.S.; Mukhopadhyay, D.S.; Nayak, T.K.; Sinha, B.C.; Trivedi, M.D.; Viyogi, Y.P. (Variable Energy Cyclotron Centre, Calcutta 700 064 (India)); Angelis, A.L.; Donni, P.; Foka, P.; Kalechofsky, H.; Martin, M.; Naef, H.; Rosselet, L.; Rubio, J.M.; Solomey, N.; Voeroes, S. (University of Geneva, CH-1211 Geneva 4 (Switzerland)); Antonenko, V.; Cherbatchev, R.; Doubovik, I.; Fokin, S.; Ippolitov, M.; Karadjev, K.; Koutcheryaev, I.; Lebedev, A.; Manko, V.; Mgebrichvili, G.; Nianine, A.; Sibiriak, I.; Tsvetkov, A.; Vinogradov, A. (RRC Kurchatov Institute, RU-123182 Moscow (Russia)); Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Baldine, A.; Barabach, L.; Batiounia, B.; Chalyshev, V.; Djordjadze, V.; Frolov, V.; Ga

    1999-08-01

    Neutral pion production in central 158A GeV [sup 208]Pb+ [sup 208] Pb collisions has been studied in the WA98 experiment at the CERN Super Proton Synchrotron. The [pi][sup 0] transverse mass spectrum has been analyzed in terms of a thermal model with hydrodynamic expansion. The high accuracy and large kinematic coverage of the measurement allow one to limit previously noted ambiguities in the extracted freeze-out parameters. The results are shown to be sensitive to the shape of the velocity distribution at freeze-out. [copyright] [ital 1999] [ital The American Physical Society

  8. Investigation of pitting resistance in ultra clean IQ-Steel vs commonly used conventional steel; 158Q vs 16MnCr5 : Back-to-back pitting tests

    OpenAIRE

    Bergseth, Ellen; Sosa, Mario; Andersson, Martin; Olofsson, Ulf

    2015-01-01

    KTH Machine Design has conducted pitting tests on gears made out of two different types of steel in a standard back-to-back pitting test rig (FZG). The tested gears were produced from Ovako’s IQ-Steel in grade 158Q and compared to the behaviour of a reference steel, commonly used conventional steel in grade 16MnCr5 (reference steel, RS). The test method is a mechanical test procedure generally used to determine the pitting load capacity of gear transmission lubricants, but in this study the p...

  9. Relações filogenéticas e diversidade de isolados de Guignardia spp oriundos de diferentes hospedeiros nas regiões ITS1-5,8S-ITS2 Phylogenetic relationships and diversity of Guignardia spp isolated from different hosts on ITS1-5,8S-ITS2 region

    Directory of Open Access Journals (Sweden)

    Ester Wickert

    2009-06-01

    Full Text Available Fungos do gênero Guignardia são frequentemente isolados em diferentes espécies de plantas, sendo muitas vezes caracterizados como fungos endofíticos. Entretanto, algumas espécies deste fungo, a exemplo de G. citricarpa e G. psidii, são causadores de importantes doenças que afetam culturas agrícolas, como a Mancha-Preta dos Citros (MPC e a podridão dos frutos de goiabeira, respectivamente. Também são apontados como causadores de manchas foliares em diferentes espécies de frutíferas e também em outras culturas. Este trabalho teve o objetivo de isolar, identificar e caracterizar a diversidade genética existente entre isolados de Guignardia oriundos de citros, mangueira, goiabeira, eucaliptos, jabuticabeira e pitangueira através da análise da sequência de DNA do cístron ITS1-5,8-S-ITS2. Verificou-se que os isolados obtidos pertencem às espécies G. citricarpa e G. mangiferae. Entretanto, dois grupos encontrados em mangueira não puderam ser identificados em nível de espécie com base em sua sequência de DNA em função da baixa similaridade com as sequências de diferentes espécies de Guignardia já depositadas em banco de dados. Desta forma, goiabeira, eucaliptos, jabuticabeira e pitangueira são hospedeiras de G. mangiferae, enquanto os citros hospedam duas formas, G. citricarpa e G. mangiferae. Já a mangueira é hospedeira de G. mangiferae e de dois outros grupos ainda não identificados. Verificou-se ainda que isolados de Guignardia obtidos de sintomas de podridão de fruto de goiabeira foram identificados como G. mangiferae.Fungi of Guignardia genera are commonly isolated from different plant species and most of the time they are characterized as endophytics. However, some species of this genus, as G. citricarpa and G. psidii are known as causal agents of serious diseases that affect cultures, such as the Citrus Black Spot and the guava fruit rot, respectively. They are also responsible for diseases that cause foliar

  10. APPLICATION OF 26S RRNA GENE SEQUENCING AND RFLP OF ITS1-5.8S-ITS2 ANALYSIS FOR THE IDENTIFICATION OF KLUYVEROMYCES STRAIN BM9 PRODUCING BIOFUEL

    Directory of Open Access Journals (Sweden)

    Virginia Wambui

    2014-04-01

    Full Text Available Cheese whey is a dairy industry waste have high lactose concentration, which case environmental problem. Therefore biofuel production from cheese whey become an interest as renewable energy. In this study 28 yeasts were isolated from Kenyan cheese whey and characterized for lactose fermentation. Out of them one isolate, designated as BM9 had high efficiency for lactose fermentation was selected. For genetically identification PCR amplification of both internal transcribed spacer (ITS and 5.8 rDNA region (ITS1-5.8S-ITS2 and the variable D1/D2 domain of the 26S rRNA gene were used. RFLP of the PCR-amplified ITS1-5.8S-ITS2 region (750 bp using two restriction enzymes HaeIII and HinfI yielded fragments with 650 + 80 bp and 250 + 190 + 120 + 80 bp respectively witch identified the isolate as Kluyveromyces marxianus. 26S rRNA of the isolate was sequenced and compared with known 26S rRNA sequences in the GenBank database. Results of 26S rRNA gene confirmed that the isolate was highly related to K. marxianus with similarity 99%. Phylogenetic analysis show that BM9 shared a one cluster with K. marxianus. The fermentative performance of the strain BM9 on cheese whey to produce bio-ethanol at different parameters such as incubation temperature, initial pH, whey sugar concentrations, and yeast concentrations was evaluated.

  11. RAPD analysis and sequencing of ITS1/5.8S rRNA/ITS2 and Fe-hydrogenase as tools for genetic classification of potentially pathogenic isolates of Trichomonas gallinae.

    Science.gov (United States)

    Sansano-Maestre, José; Martínez-Herrero, María Del Carmen; Garijo-Toledo, María Magdalena; Gómez-Muñoz, María Teresa

    2016-08-01

    Trichomonas gallinae is a worldwide parasite that causes oropharyngeal avian trichomonosis. During eight years, 60 axenic isolates were obtained from different bird species and characterized by three molecular methods: RAPD analysis and PCR-sequencing of ITS1/5.8S rRNA/ITS2 fragment and Fe-hydrogenase gene. We have found two genotypes of ITS1/5.8S rRNA/ITS2 widely distributed among bird populations, a new variant and also two sequences with mixed pattern. Genotype ITS-OBT-Tg-1 was associated with the presence of gross lesions in birds. We have found eight genotypes of the Fe-hydrogenase (A1, A2, C2, C2.1, C4, C5, C6 and C7), three of them are new reports (C5, C6 and C7), and also three sequences with mixed pattern. Subtype A1 of the Fe-hydrogenase was also related with the presence of lesions. RAPD analyses included most of the strains isolated from animals with lesions in one of the sub-clusters. Potentially pathogenic isolates of T. gallinae obtained in this study fulfill the following criteria with one exception: isolated from lesions+ITS-OBT-Tg-1 genotype+FeHyd A1+RAPD sub-cluster I2. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. White matter alterations related to attention-deficit hyperactivity disorder and COMT val158met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus

    Directory of Open Access Journals (Sweden)

    Kabukcu Basay B

    2016-04-01

    Full Text Available Burge Kabukcu Basay,1 Ahmet Buber,1 Omer Basay,1 Huseyin Alacam,2 Onder Ozturk,1 Serkan Suren,3 Ozlem Izci Ay,4 Cengizhan Acikel,5 Kadir Agladioglu,6 Mehmet Emin Erdal,4 Eyup Sabri Ercan,7 Hasan Herken21Child and Adolescent Psychiatry Department, Pamukkale University Medical Faculty, Denizli, 2Psychiatry Department, Pamukkale University Medical Faculty, Denizli, 3Medical Park Samsun Hospital, Samsun, 4Medical Biology and Genetics Department, Mersin University Medical Faculty, Mersin, 5Biostatistics Department, GATA (GMMA, Ankara, 6Radiology Department, Pamukkale University Medical Faculty, Denizli, 7Child and Adolescent Psychiatry Department, Ege University Medical Faculty, Izmir, TurkeyIntroduction: In this article, the COMT gene val158met polymorphism and attention-deficit hyperactivity disorder (ADHD-related differences in diffusion-tensor-imaging-measured white matter (WM structure in children with ADHD and controls were investigated.Patients and methods: A total of 71 children diagnosed with ADHD and 24 controls aged 8–15 years were recruited. Using diffusion tensor imaging, COMT polymorphism and ADHD-related WM alterations were investigated, and any interaction effect between the COMT polymorphism and ADHD was also examined. The effects of age, sex, and estimated total IQ were controlled by multivariate analysis of covariance (MANCOVA.Results: First, an interaction between the COMT val158met polymorphism and ADHD in the right (R cingulum (cingulate gyrus (CGC was found. According to this, valine (val homozygote ADHD-diagnosed children had significantly lower fractional anisotropy (FA and higher radial diffusivity (RD in the R-CGC than ADHD-diagnosed methionine (met carriers, and val homozygote controls had higher FA and lower RD in the R-CGC than val homozygote ADHD patients. Second, met carriers had higher FA and axial diffusivity in the left (L-uncinate fasciculus and lower RD in the L-posterior corona radiata and L

  13. COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: a diffusion tensor imaging study

    Directory of Open Access Journals (Sweden)

    Hayashi K

    2014-06-01

    Full Text Available Kenji Hayashi,1 Reiji Yoshimura,1 Shingo Kakeda,2 Taro Kishi,3 Osamu Abe,4 Wakako Umene-Nakano,1 Asuka Katsuki,1 Hikaru Hori,1 Atsuko Ikenouchi-Sugita,1 Keita Watanabe,2 Satoru Ide,2 Issei Ueda,2 Junji Moriya,2 Nakao Iwata,3 Yukunori Korogi,2 Marek Kubicki,5 Jun Nakamura1 1Department of Psychiatry, 2Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan; 3Department of Psychiatry, Fujita Health University, Toyoake, Japan; 4Department of Radiology, Nihon University School of Medicine, Tokyo, Japan; 5Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Abstract: We investigated the association between the Val158Met polymorphism of the catechol-O-methyltransferase (COMT gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF gene, and white matter changes in patients with major depressive disorder (MDD and healthy subjects using diffusion tensor imaging (DTI. We studied 30 patients with MDD (17 males and 13 females, with mean age ± standard deviation [SD] =44±12 years and 30 sex- and age-matched healthy controls (17 males and 13 females, aged 44±13 years. Using DTI analysis with a tract-based spatial statistics (TBSS approach, we investigated the differences in fractional anisotropy, radial diffusivity, and axial diffusivity distribution among the three groups (patients with the COMT gene Val158Met, those with the BDNF gene Val66Met, and the healthy subjects. In a voxel-wise-based group comparison, we found significant decreases in fractional anisotropy and axial diffusivity within the temporal lobe white matter in the Met-carriers with MDD compared with the controls (P<0.05. No correlations in fractional anisotropy, axial diffusivity, or radial diffusivity were observed between the MDD patients and the controls, either among those with the BDNF Val/Val genotype or among the BDNF Met-carriers. These results suggest an association

  14. Inelastic scattering of neutrons by spin waves in terbium

    DEFF Research Database (Denmark)

    Bjerrum Møller, Hans; Houmann, Jens Christian Gylden

    1966-01-01

    Measurements of spin-wave dispersion relations for magnons propagating in symmetry directions in ferromagnetic Tb; it is first experiment to give detailed information on magnetic excitations in heavy rare earths; Tb was chosen for these measurements because it is one of few rare-earth metals whic...... does not have very high thermal-neutron capture cross section, so that inelastic neutron scattering experiments can give satisfactory information on magnon dispersion relations....

  15. Coherent magnetic structures in terbium/holmium superlattices

    DEFF Research Database (Denmark)

    Bryn-Jacobsen, C.; Cowley, R.A.; McMorrow, D.F.

    1997-01-01

    Neutron-scattering techniques have been used to investigate the magnetic properties of three Tb/Ho superlattices grown by molecular-beam epitaxy. It is revealed that for temperatures in the range T = 10 to T-N(Ho)approximate to 130 K, there is a basal-plane ferromagnetic alignment of Tb moments w...

  16. Measurements of π{sup ±}, K{sup ±}, p and p spectra in proton-proton interactions at 20, 31, 40, 80 and 158 GeV/c with the NA61/SHINE spectrometer at the CERN SPS

    Energy Technology Data Exchange (ETDEWEB)

    Aduszkiewicz, A.; Dominik, W.; Kuich, M.; Matulewicz, T.; Podlaski, P.; Posiadala, M.; Walewski, M. [University of Warsaw, Warsaw (Poland); Ali, Y.; Brzychczyk, J.; Larsen, D.; Planeta, R.; Richter-Was, E.; Staszel, P.; Wyszynski, O. [Jagiellonian University, Krakow (Poland); Andronov, E.; Feofilov, G.A.; Igolkin, S.; Kondratiev, V.P.; Kovalenko, V.; Merzlaya, A.; Seryakov, A.; Vechernin, V.V.; Vinogradov, L. [St. Petersburg State University, St. Petersburg (Russian Federation); Anticic, T.; Kadija, K.; Susa, T. [Ruder Boskovic Institute, Zagreb (Croatia); Baatar, B.; Bunyatov, S.A.; Kireyeu, V.A.; Kolesnikov, V.I.; Krasnoperov, A.; Lyubushkin, V.V.; Malakhov, A.I.; Matveev, V.; Melkumov, G.L.; Tereshchenko, V. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Baszczyk, M.; Dorosz, P.; Kucewicz, W.; Mik, L. [University of Science and Technology, Krakow (Poland); Bhosale, S.; Davis, N.; Kielbowicz, M.; Marcinek, A.; Ozvenchuk, V.; Rybicki, A. [H. Niewodniczanski Institute of Nuclear Physics of the Polish Academy of Sciences, Krakow (Poland); Blondel, A.; Bravar, A.; Damyanova, A.; Haesler, A.; Korzenev, A.; Ravonel, M. [University of Geneva, Geneva (Switzerland); Bogomilov, M.; Kolev, D.; Tsenov, R. [University of Sofia, Faculty of Physics, Sofia (Bulgaria); Brandin, A.; Selyuzhenkov, I.; Strikhanov, M.; Taranenko, A. [National Research Nuclear University (Moscow Engineering Physics Institute), Moscow (Russian Federation); Busygina, O.; Golubeva, M.; Guber, F.; Ivashkin, A.; Kurepin, A.; Sadovsky, A. [Institute for Nuclear Research, Moscow (Russian Federation); Cherif, H.; Deveaux, M.; Klochkov, V.; Koziel, M.; Renfordt, R.; Snoch, A.; Stroebele, H.; Toia, A. [University of Frankfurt, Frankfurt (Germany); Cirkovic, M.; Knezevic, N.; Manic, D.; Puzovic, J. [University of Belgrade, Belgrade (Serbia); Czopowicz, T.; Grebieszkow, K.; Mackowiak-Pawlowska, M.; Maksiak, B.; Slodkowski, M.; Tefelska, A.; Tefelski, D. [Warsaw University of Technology, Warsaw (Poland); Dembinski, H.; Engel, R.; Herve, A.E.; Mathes, H.J.; Roth, M.; Szuba, M.; Ulrich, R.; Unger, M.; Veberic, D. [Karlsruhe Institute of Technology, Karlsruhe (Germany); Dumarchez, J. [University of Paris VI and VII, LPNHE, Paris (France); Ereditato, A.; Francois, C.; Pistillo, C.; Wilkinson, C. [University of Bern, Bern (Switzerland); Fodor, Z. [Wigner Research Centre for Physics of the Hungarian Academy of Sciences, Budapest (Hungary); University of Wroclaw, Wroclaw (Poland); Garibov, A. [National Nuclear Research Center, Baku (Azerbaijan); Gazdzicki, M. [University of Frankfurt, Frankfurt (Germany); Jan Kochanowski University in Kielce, Kielce (Poland); Hylen, J.; Lundberg, B.; Marchionni, A.; Rameika, R.; Zwaska, R. [Fermilab, Batavia (United States); Johnson, S.R.; Marino, A.D.; Nagai, Y.; Rumberger, B.T.; Zimmerman, E.D. [University of Colorado, Boulder (United States); Kaptur, E.; Kowalski, S.; Lysakowski, B.; Pulawski, S.; Schmidt, K. [University of Silesia, Katowice (Poland); Kowalik, K.; Rondio, E.; Stepaniak, J. [National Centre for Nuclear Research, Warsaw (Poland); Laszlo, A.; Marton, K.; Vesztergombi, G. [Wigner Research Centre for Physics of the Hungarian Academy of Sciences, Budapest (Hungary); Lewicki, M.; Naskret, M.; Turko, L. [University of Wroclaw, Wroclaw (Poland); Messerly, B.; Paolone, V.; Wickremasinghe, A. [University of Pittsburgh, Pittsburgh (United States); Mills, G.B. [Los Alamos National Laboratory, Los Alamos (United States); Morozov, S.; Petukhov, O. [Institute for Nuclear Research, Moscow (Russian Federation); National Research Nuclear University (Moscow Engineering Physics Institute), Moscow (Russian Federation); Mrowczynski, S.; Rybczynski, M.; Seyboth, P.; Stefanek, G.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A. [Jan Kochanowski University in Kielce, Kielce (Poland); Pavin, M. [Ruder Boskovic Institute, Zagreb (Croatia); University of Paris VI and VII, LPNHE, Paris (France); Popov, B.A. [University of Paris VI and VII, LPNHE, Paris (France); Joint Institute for Nuclear Research, Dubna (Russian Federation); Rauch, W. [Fachhochschule Frankfurt, Frankfurt (Germany); Roehrich, D. [University of Bergen, Bergen (Norway); Rustamov, A. [National Nuclear Research Center, Baku (Azerbaijan); University of Frankfurt, Frankfurt (Germany); Zambelli, L. [National Nuclear Research Center, Baku (Azerbaijan); University of Paris VI and VII, LPNHE, Paris (France); Collaboration: The NA61/SHINE Collaboration

    2017-10-15

    Measurements of inclusive spectra and mean multiplicities of π{sup ±}, K{sup ±}, p and p produced in inelastic p + p interactions at incident projectile momenta of 20, 31, 40, 80 and 158 GeV/c (√(s) = 6.3, 7.7, 8.8, 12.3 and 17.3 GeV, respectively) were performed at the CERN Super Proton Synchrotron using the large acceptance NA61/SHINE hadron spectrometer. Spectra are presented as function of rapidity and transverse momentum and are compared to predictions of current models. The measurements serve as the baseline in the NA61/SHINE study of the properties of the onset of deconfinement and search for the critical point of strongly interacting matter. (orig.)

  17. Pion freeze-out time in Pb+Pb collisions at 158 AGeV/c studied via {pi}{sup -}/{pi}{sup +} and K{sup -}/K{sup +} ratios

    Energy Technology Data Exchange (ETDEWEB)

    Aggarwal, M.M.; Bhatia, V.S.; Sood, G. [University of Panjab, Chandigarh (India); Ahammed, Z.; Chattopadhyay, S.; Dutta Majumdar, M.R.; Ganti, M.S.; Mukhopadhyay, D.S.; Nayak, T.K.; Sinha, B.C.; Viyogi, Y.P. [Variable Energy Cyclotron Centre, Calcutta (India); Angelis, A.L.S.; Donni, P.; Kalechofsky, H.; Martin, M.; Naef, H.; Rosselet, L.; Rubio, J.M.; Voeroes, S. [University of Geneva, Geneva 4 (Switzerland); Antonenko, V.; Fokin, S.; Ippolitov, M.; Karadjev, K.; Koutcheryaev, I.; Lebedev, A.; Manko, V.; Mukhanova, T.; Nianine, A.; Nikolaev, S.; Peressounko, D.; Sibiriak, I.; Tsvetkov, A.; Vinogradov, A. [RRC Kurchatov Institute, Moscow (Russian Federation); Arefiev, V.; Astakhov, V.; Avdeitchikov, V.; Batiounia, B.; Frolov, V.; Gavrishchuk, O.; Guskov, B.; Kosarev, I.; Maximov, A.; Nikitine, V.; Nomokonov, P.; Pavliouk, S.; Roufanov, I.; Shabratova, G.; Slavine, N.; Vodopianov, A. [Joint Institute for Nuclear Research, Dubna (Russian Federation); Awes, T.C.; Plasil, F.; Stankus, P.; Young, G.R. [Oak Ridge National Laboratory, Oak Ridge, TN (United States); Baba, P.V.K.S.; Badyal, S.K.; Rao, N.K.; Sambyal, S.S.; Shah, T.H. [University of Jammu, Jammu (India); Bathe, S.; Blume, C.; Bucher, D.; Buesching, H.; Glasow, R.; Reygers, K.; Santo, R.; Schlagheck, H. [University of Muenster, Muenster (Germany); Bernier, T.; Delagrange, H.; Luquin, L.; Martinez, G.; Mora, M.-J.; Nayak, S.K.; Pinganaud, W.; Retiere, F.; Roy, C.; Schutz, Y. [Ecole des Mines, SUBATECH, Nantes (France); Bhalla, K.B.; Raniwala, R.; Raniwala, S. [University of Rajasthan, Jaipur, Rajasthan (India); Carlen, L.; El Chenawi, K.; Garpman, S.; Aa.Gustafsson, H.; Nilsson, P.; Nystrand, J.; Oskarsson, A.; Otterlund, I.; Silvermyr, D.; Soederstroem, K.; Stenlund, E.; Svensson, T. [Lund University, Lund (Sweden); Decowski, M.P.; Kulinich, P.; Roland, G.; Steinberg, P.; v. Nieuwenhuizen, G.J.; Wyslouch, B. [MIT, Cambridge, MA (United States)] [and others

    2006-11-15

    The effect of the final state Coulomb interaction on particles produced in Pb+Pb collisions at 158 AGeV/c has been investigated in the WA98 experiment through the study of the {pi}{sup -}/{pi}{sup +} and K{sup -}/K{sup +} ratios measured as a function of m{sub T}-m{sub 0}. While the ratio for kaons shows no significant m{sub T} dependence, the {pi}{sup -}/{pi}{sup +} ratio is enhanced at small m{sub T}-m{sub 0} values with an enhancement that increases with centrality. A silicon pad detector located near the target is used to estimate the contribution of hyperon decays to the {pi}{sup -}/{pi}{sup +} ratio. The comparison of results with predictions of the RQMD model in which the Coulomb interaction has been incorporated allows to place constraints on the time of the pion freeze-out. (orig.)

  18. Measurements of pion, kaon, proton and anti-proton spectra in proton-proton interactions at 20, 31, 40, 80 and 158 GeV/c with the NA61/SHINE spectrometer at the CERN SPS

    CERN Document Server

    Aduszkiewicz, A.; The NA61 collaboration; Andronov, E.; Antićić, T.; Baatar, B.; Baszczyk, M.; Bhosale, S.; Blondel, A.; Bogomilov, M.; Brandin, A.; Bravar, A.; Brzychczyk, J.; Bunyatov, S.A.; Busygina, O.; Cherif, H.; Ćirković, M.; Czopowicz, T.; Damyanova, A.; Davis, N.; Dembinski, H.; Deveaux, M.; Dominik, W.; Dorosz, P.; Dumarchez, J.; Engel, R.; Ereditato, A.; Feofilov, G.A.; Fodor, Z.; Francois, C.; Garibov, A.; Gaździcki, M.; Golubeva, M.; Grebieszkow, K.; Guber, F.; Haesler, A.; Hervé, A.E.; Hylen, J.; Igolkin, S.; Ivashkin, A.; Johnson, S.R.; Kadija, K.; Kaptur, E.; Kiełbowicz, M.; Kireyeu, V.A.; Klochkov, V.; Knezević, N.; Kolesnikov, V.I.; Kolev, D.; Kondratiev, V.P.; Korzenev, A.; Kovalenko, Vladimir; Kowalik, K.; Kowalski, S.; Koziel, M.; Krasnoperov, A.; Kucewicz, W.; Kuich, M.; Kurepin, A.; Larsen, D.; László, A.; Lewicki, M.; Lundberg, B.; Lyubushkin, V.V.; Łysakowski, B.; Maćkowiak-Pawłowska, M.; Maksiak, B.; Malakhov, A.I.; Manić, D.; Marchionni, A.; Marcinek, A.; Marino, A.D.; Marton, K.; Mathes, H.-J.; Matulewicz, T.; Matveev, V.; Melkumov, G.L.; Merzlaya, A.; Messerly, B.; Mik, Ł.; Mills, G.B.; Morozov, S.; Mrówczyński, S.; Nagai, Y.; Naskręt, M.; Ozvenchuk, V.; Paolone, V.; Pavin, M.; Petukhov, O.; Pistillo, C.; Płaneta, R.; Podlaski, P.; Popov, B.A.; Posiadała, M.; Puławski, S.; Puzović, J.; Rameika, R.; Rauch, W.; Ravonel, M.; Renfordt, R.; Richter-Wąs, E.; Röhrich, D.; Rondio, E.; Roth, M.; Rumberger, B.T.; Rustamov, A.; Rybczynski, M.; Rybicki, A.; Sadovsky, A.; Schmidt, K.; Selyuzhenkov, I.; Seryakov, A.; Seyboth, P.; Słodkowski, M.; Snoch, A.; Staszel, P.; Stefanek, G.; Stepaniak, J.; Strikhanov, M.; Ströbele, H.; Šuša, T.; Szuba, M.; Taranenko, A.; Tefelska, A.; Tefelski, D.; Tereshchenko, V.; Toia, A.; Tsenov, R.; Turko, L.; Ulrich, R.; Unger, M.; Veberič, D.; Vechernin, V.V.; Vesztergombi, G.; Vinogradov, L.; Walewski, M.; Wickremasinghe, A.; Wilkinson, C.; Włodarczyk, Z.; Wojtaszek-Szwarc, A.; Wyszyński, O.; Zambelli, L.; Zimmerman, E.D.; Zwaska, R.

    2017-10-10

    Measurements of inclusive spectra and mean multiplicities of pions, kaons, protons and anti-protons produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158 GeV/c (c.m. energy = 6.3, 7.7, 8.8, 12.3 and 17.3 GeV, respectively) were performed at the CERN Super Proton Synchrotron using the large acceptance NA61/SHINE hadron spectrometer. Spectra are presented as function of rapidity and transverse momentum and are compared to predictions of current models. The measurements serve as the baseline in the NA61/SHINE study of the properties of the onset of deconfinement and search for the critical point of strongly interacting matter.

  19. Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in Healthy Subjects: Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging.

    Directory of Open Access Journals (Sweden)

    Keita Watanabe

    Full Text Available The effect of the catechol-O-methyltransferase (COMT Val158Met polymorphism on brain morphology has been investigated but remains controversial. We hypothesized that a comparison between Val/Val and Val/Met individuals, which may represent the most different combinations concerning the effects of the COMT genotype, may reveal new findings. We investigated the brain morphology using 3-Tesla magnetic resonance imaging in 27 Val/Val and 22 Val/Met individuals. Voxel-based morphometry revealed that the volumes of the bilateral caudate and posterior cingulate cortex were significantly smaller in Val/Val individuals than in Val/Met individuals [right caudate: false discovery rate (FDR-corrected p = 0.048; left caudate: FDR-corrected p = 0.048; and bilateral posterior cingulate cortex: FDR-corrected p = 0.048]. This study demonstrates that interacting functional variants of COMT affect gray matter regional volumes in healthy subjects.

  20. The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study.

    Science.gov (United States)

    Coman, Ioana L; Gnirke, Matthew H; Middleton, Frank A; Antshel, Kevin M; Fremont, Wanda; Higgins, Anne Marie; Shprintzen, Robert J; Kates, Wendy R

    2010-11-15

    Velo-cardio-facial syndrome (VCFS) is caused by a micro-deletion of over 40 genes at the q11.2 locus of chromosome 22 and is a risk factor for the development of schizophrenia and other psychiatric disorders. COMT, one of the genes located in the deleted region, has been considered as a major candidate gene for genetic susceptibility in psychiatric diseases. Its functional polymorphism Val108/158Met has been shown to affect prefrontal function and working memory and has been associated with emotional dysregulation. We utilized a functional magnetic resonance imaging (fMRI) event-related paradigm to asses COMT genotype and gender-moderated effects on the neural activation that are elicited by viewing emotionally salient images charged with pleasant, unpleasant, and neutral content. Since estrogen down-regulates COMT activity resulting in lower COMT activity in women than men, we hypothesized an allele-by-gender interaction effect on neural activation. Participants included 43 VCFS individuals (Val/male=9, Val/female=17, Met/male=9, Met/female=8). We observed a gender effect on processing positive emotions, in that girls activated the cingulate gyrus more than boys did. We further observed a significant gender-by-allele interaction effect on neural function specific to the frontal lobe during the processing of pleasant stimuli, and specific to limbic regions during the processing of unpleasant stimuli. Our results suggest that in VCFS, the effect of the COMT Val108/158Met polymorphism is moderated by gender during the processing of emotional stimuli and could contribute to the understanding of the way in which this COMT polymorphism affects vulnerability to neuropsychiatric disorders. Copyright 2010 Elsevier Inc. All rights reserved.

  1. The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects.

    Science.gov (United States)

    Yang, Mei; Kavi, Vasish; Wang, Wenfu; Wu, Zhimei; Hao, Wei

    2012-03-30

    To explore the association between the 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR polymorphisms with comorbidity of antisocial personality disorder in male heroin-dependent patients. In case control study, we compared the polymorphic distributions of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR in 588 male heroin-dependent patients (including 311 patients with antisocial personality disorder and 277 patients without antisocial personality disorder) and 194 normal males by genotypes, alleles, and interaction between genes. Between male heroin-dependent patients with antisocial personality disorder and normal males, and between male heroin-dependent patients with and without antisocial personality disorder, the distributions of 5-HTTVNTR polymorphic genotypes and alleles were in statistical significance. Individuals carrying 10R allele were in higher risk of the comorbidity of antisocial personality disorder and heroin dependence. By MDR analyses, the interaction between 5-HTTVNTR and DATVNTR was close to statistical significance in predicting the risk of antisocial personality disorder in male heroin dependent patients. In male heroin dependent patients, individuals carrying 5-HTTVNTR 10R allele or/and DATVNTR 9R allele were in higher risks of co-occurring antisocial personality disorder, while individuals with 5-HTTVNTR 12R/12R and DATVNTR 10R/10R genotypes together were in lower risks of antisocial personality disorder. 5-HTTVNTR, and the interaction between 5-HTTVNTR and DATVNTR may be associated with the comorbidity of antisocial personality disorder in male heroin-dependent patients. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Partial pressure (or fugacity) of carbon dioxide, salinity and other variables collected from time series observations using Bubble type equilibrator for autonomous carbon dioxide (CO2) measurement, Carbon dioxide (CO2) gas analyzer and other instruments from MOORING_CRIMP2_158W_21N in the Kaneohe Bay and North Pacific Ocean from 2008-06-11 to 2015-05-13 (NCEI Accession 0157415)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0157415 includes chemical, meteorological, physical and time series data collected from MOORING_CRIMP2_158W_21N in the Kaneohe Bay, North Pacific...

  3. Partial pressure (or fugacity) of carbon dioxide, pH, salinity and other variables collected from time series observations using Bubble type equilibrator for autonomous carbon dioxide (CO2) measurement, Carbon dioxide (CO2) gas analyzer and other instruments from MOORING_KANEOHE_158W_21N in the North Pacific Ocean from 2011-09-30 to 2015-05-06 (NCEI Accession 0157297)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0157297 includes chemical, meteorological, physical and time series data collected from MOORING_KANEOHE_158W_21N in the North Pacific Ocean from...

  4. KEDUDUKAN BPN RI DALAM MENGHADAPI PROBLEMATIK PUTUSAN NON-EXECUTABLE PENGADILAN TATA USAHA NEGARA TENTANG PEMBATALAN SERTIPIKAT HAK ATAS TANAH (ANOTASI PUTUSAN MAHKAMAH AGUNG RI NO. 158/PK/TUN/2011 TENTANG PEMBATALAN SERTIPIKAT HAK GUNA BANGUNAN NO. 132

    Directory of Open Access Journals (Sweden)

    Rani Arvita

    2016-06-01

    Full Text Available The existence of a lawsuit in court against the certificate is not a new thing anymore , given stelsel adopted in the system of land registration in Indonesia is negative stelsel positive tendency . If on the certificate that was sued earlier , based on court decisions that have permanent legal force ( inkracht van gewisjde should be revoked and canceled by the National Land Agency, but de facto the decision can not be implemented by the National Land Agency with some particular reason , then this is where the role of National Pertanahann Agency to be able to realize the judgment which can not be implemented as Non - Executable decision. In this study will answer perrmasalahan , namely : Why is the National Land Agency wants the Indonesian Supreme Court Decision 158 / PK / TUN / 2011 on Cancellation of Certificate Broking No. 132 on behalf of PT . TOP As the verdict of Non - Executable ?, How the National Land Agency Role In Delivering the Indonesian Supreme Court Decision 158 / PK / TUN / 2011 As a verdict of Non - Executable ? How Legal Certainty The winner of the Indonesian Supreme Court Decision 158 / PK / TUN / 2011 and the Justice and Legal Protection against the owner of Certificate Broking No. 132 Certificate of derivatives and their owners ? To address this problem used approach Legislation , Case Approach , Conceptual Approach , Approach Sociology of Law and Political Law. Based on the survey results revealed that : First , there are two main reasons why the National Land Agency wants the Supreme Court Decision No. 158 / PK / TUN / 2011 as Non - Executable ruling that reasons are normative juridical considerations and Juridical Technical . Pertimbangann normative juridical reason is that the decision of cancellation of the Certificate Broking No. 132 on behalf of PT . TOP is overdue / expired / verjaring , Ultra Petita and filed by the plaintiffs who do not have other interests and there is a decision in the administrative court ruling

  5. Polimorfismo Val108/158Met en el gen dopaminérgico catecol-o-metil transferasa (COMT en una población mixta peruana y su importancia para los estudios neuropsiquiátricos

    Directory of Open Access Journals (Sweden)

    Doris Huerta

    2007-12-01

    Full Text Available Introducción: El gen dopaminérgico catecol-o-metil transferasa (COMT, tiene un polimorfismo funcional Val108/158Met que da lugar a variantes de la enzima que cataliza la o-metilación de las catecolaminas activas, participando en el metabolismo de las drogas y neurotransmisores, como la L-dopa, norepinefrina, epinefrina y dopamina y, por consiguiente, puede asociarse a condiciones neuropsiquiátricas. Objetivos: Determinar las frecuencias genotípicas y alélicas del polimorfismo Val108/158Met del gen COMT en sujetos saludables de una población mixta peruana y establecer las implicancias para el estudio genético de enfermedades y otras condiciones neuropsiquiátricas. Diseño: Estudio descriptivo, observacional, transversal. Lugar: Centro de Investigación de Bioquímica y Nutrición ‘Alberto Guzmán Barrón’. Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Participantes: Ciento seis personas, hombres y mujeres, clínicamente saludables, sin enfermedades neurológicas ni mentales u otra patología similar, voluntarios con consentimiento informado, sin relación de parentesco, todos residentes en Lima, cuyas edades fluctuaban entre los 18 y 50 años. Intervenciones: Extracción del ADN genómico a partir de células de epitelio bucal, según metodología estándar. Amplificación mediante la PCR con primers específicos y digestión con la enzima de restricción NlaIII. Detección de fragmentos de restricción de longitud polimórfica (RFLP por electroforesis en gel de poliacrilamida al 6%, teñido con nitrato de plata. Principales medidas de resultados: Frecuencias genotípicas y alélicas del gen COMT en población mixta peruana. Resultados: Se encontró las frecuencias genotípicas Met/Met=0,0661, Val/Met=0,5094 y Val/Val=0,4245, siendo la distribución consistente con el equilibrio de Hardy-Weinberg (X² =3,0317, g.l.=1, p >0,05. Las frecuencias alélicas encontradas fueron alelo Val=0,68 y el alelo Met=0

  6. The role of catechol-O-methyl transferase Val(108/158Met polymorphism (rs4680 in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study.

    Directory of Open Access Journals (Sweden)

    Rick Hursel

    Full Text Available INTRODUCTION: Green tea(GT is able to increase energy expenditure(EE and fat oxidation(FATox via inhibition of catechol-O-methyl transferase(COMT by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the functional COMT Val108/158Met polymorphism that are associated with COMT enzyme activity; high-activity enzyme, COMT(H(Val/Val genotype, and low-activity COMT(L(Met/Met genotype. METHODS: Fourteen Caucasian subjects (BMI: 22.2±2.3 kg/m2, age: 21.4±2.2 years of whom 7 with the COMT(H-genotype and 7 with the COMT(L-genotype were included in a randomized, cross-over study in which EE and substrate oxidation were measured with a ventilated-hood system after decaffeinated GT and placebo(PL consumption. RESULTS: At baseline, EE, RQ, FATox and carbohydrate oxidation(CHOox did not differ between groups. Significant interactions were observed between COMT genotypes and treatment for RQ, FATox and CHOox (p<0.05. After GT vs. PL, EE(GT: 62.2 vs. PL: 35.4 kJ.3.5 hrs; p<0.01, RQ(GT: 0.80 vs. PL: 0.83; p<0.01, FATox(GT: 18.3 vs. PL: 15.3 g/d; p<0.001 and CHOox(GT: 18.5 vs. PL: 24.3 g/d; p<0.001 were significantly different for subjects carrying the COMT(H genotype, but not for subjects carrying the COMT(L genotype (EE, GT: 60.3 vs. PL: 51.7 kJ.3.5 hrs; NS, (RQ, GT: 0.81 vs. PL: 0.81; NS, (FATox, GT: 17.3 vs. PL: 17.0 g/d; NS, (CHOox, GT: 22.1 vs. PL: 21.4 g/d; NS. CONCLUSION: Subjects carrying the COMT(H genotype increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs, placebo, whereas COMT(L genotype carriers reacted similarly to GT and PL ingestion. The differences in responses were due to the different responses on PL ingestion, but similar responses to GT ingestion, pointing to different mechanisms. The different alleles of the functional COMT Val108/158Met polymorphism appear to play a role in the inter

  7. 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole as a reactivity probe for the investigation of the thiol proteinases. evidence that ficin and bromelain may lack carboxyl groups conformationally equivalent to that of aspartic acid-158 of papain.

    Science.gov (United States)

    Shipton, M; Stuchbury, T; Brocklehurst, K

    1976-01-01

    1. 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (Nbd chloride) was used as a reactivity probe to characterize the active centres of papin (EC 3.4.22.2), ficin (EC 3.4.22.3) and bromelain (EC 3.4.22.4). 2. In the pH range 0-8 Nbd chloride probably exists mainly as a monocation, possibly with the proton located on N-1 of the oxadiazole ring. 3. Spectroscopic evidence is presented for the intermediacy of Meisenheimer-type adducts in the reaction of Nbd chloride with nucleophiles. 4. The pH-dependence of the second-order rate constants (k) of the reactions of the three enzymes with Nbd chloride was determined at 25 degrees C, I = 0.1 mol/litre in 6.7% (v/v) ethanol in the pH range 2.5-5, where, at least for papain and ficin, the reactions occur specifically with their active-centre thiol groups. The pH-k profile for the papain reaction is bell-shaped (pKaI = 3.24, pKaII = 3.44 and k = 86M(-1)-s(-1), whereas that for ficin is sigmoidal (pKa = 3.6, k = 0.36M(-1)-s(-1), the rate increasing with increasing pH. The profile for the bromelain reaction appears to resemble that for the ficin reaction, but is complicated by amino-group labelling. 5. The bell-shaped profile of the papain reaction is considered to arise from the reaction of the thiolate ion of cysteine-25, maintained in acidic media by interaction with the side chain of histidine-159, with the Nbd chloride monocation hydrogen-bonded at its nitro group to the un-ionized form of the carboxyl group of aspartic acid-158. The lack of acid catalysis in the corresponding reactions of ficin and probably of bromelain suggests that these enzymes may lack carboxyl groups conformationally equivalent to that of aspartic acid-158 of papain. The possible consequences of this for the catalytic sites of these enzymes is discussed. PMID:11778

  8. Beam-loss induced pressure rise of Large Hadron Collider collimator materials irradiated with 158  GeV/u In^{49+} ions at the CERN Super Proton Synchrotron

    Directory of Open Access Journals (Sweden)

    E. Mahner

    2004-10-01

    Full Text Available During heavy ion operation, large pressure rises, up to a few orders of magnitude, were observed at CERN, GSI, and BNL. The dynamic pressure rises were triggered by lost beam ions that impacted onto the vacuum chamber walls and desorbed about 10^{4} to 10^{7} molecules per ion. The deterioration of the dynamic vacuum conditions can enhance charge-exchange beam losses and can lead to beam instabilities or even to beam abortion triggered by vacuum interlocks. Consequently, a dedicated measurement of heavy-ion induced molecular desorption in the GeV/u energy range is important for Large Hadron Collider (LHC ion operation. In 2003, a desorption experiment was installed at the Super Proton Synchrotron to measure the beam-loss induced pressure rise of potential LHC collimator materials. Samples of bare graphite, sputter coated (Cu, TiZrV graphite, and 316 LN (low carbon with nitrogen stainless steel were irradiated under grazing angle with 158  GeV/u indium ions. After a description of the new experimental setup, the results of the pressure rise measurements are presented, and the derived desorption yields are compared with data from other experiments.

  9. Assessment of the repeatability and border-plate effects of the B158/B60 enzyme-linked-immunosorbent assay for the detection of circulating antigens (Ag-ELISA) of Taenia saginata.

    Science.gov (United States)

    Jansen, Famke; Dorny, Pierre; Berkvens, Dirk; Van Hul, Anke; Van den Broeck, Nick; Makay, Caroline; Praet, Nicolas; Gabriël, Sarah

    2016-08-30

    The monoclonal antibody-based circulating antigen detecting ELISA (B158/B60 Ag-ELISA) has been used elaborately in several studies for the diagnosis of human, bovine and porcine cysticercosis. Interpretation of test results requires a good knowledge of the test characteristics, including the repeatability and the effect of the borders of the ELISA plates. Repeatability was tested for 4 antigen-negative and 5 antigen-positive reference bovine serum samples by calculating the Percentage Coefficient of Variation (%CV) within and between plates, within and between runs, overall, for two batches of monoclonal antibodies and by 2 laboratory technicians. All CV values obtained were below 20% (except one: 24.45%), which indicates a good repeatability and a negligible technician error. The value of 24.45% for indicating the variability between batches of monoclonal antibodies for one positive sample is still acceptable for repeatability measures. Border effects were determined by calculating the %CV values between the inner and outer wells of one plate for 2 positive serum samples. Variability is a little more present in the outer wells but this effect is very small and no significant border effect was found. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141C Ins/Del) and dopamine degradation enzyme (COMT G158A, A-278G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders.

    Science.gov (United States)

    Lafuente, Amalia; Bernardo, Miquel; Mas, Sergi; Crescenti, Anna; Aparici, Monica; Gasso, Patricia; Deulofeu, Ramon; Mane, Anna; Catalan, Rosa; Carne, Xavier

    2008-11-30

    The relationship is examined of the dopamine D2 receptor (DRD2) polymorphism (TaqIA, TaqIB, -141 C Ins/Del) and the catechol-O-methyltransferase (COMT) polymorphism (A-278G, G158A) to the risk of antipsychotic-induced extrapyramidal symptoms (EPS) in schizophrenia and bipolar disorders. Participants comprised 80 cases presenting with EPS (Simpson-Angus Scale score >3) and 188 controls presenting without EPS (Simpson-Angus Scale score

  11. Evidence for the production of thermal-like muon pairs with masses above 1 GeV/c^2 in 158A GeV Indium-Indium Collisions

    CERN Document Server

    Arnaldi, R; Borer, K; Castor, J; Chaurand, B; Chen, W; Cical, C; Colla, A; Cortese, P; Damjanovic, S; David, A; De Falco, A; Devaux, A; Ducroux, L; Enyo, H; Fargeix, J; Ferretti, A; Floris, M; Frster, A; Force, P; Guettet, N; Guichard, A; Gulkanian, H R; Heuser, J M; Keil, M; Kluberg, L; Li, Z; Loureno, C; Lozano, J; Manso, F; Martins, P; Masoni, A; Neves, A; Ohnishi, H; Oppedisano, C; Parracho, P; Pillot, P; Poghosyan, T; Puddu, G; Radermacher, E; Ramalhete, P; Rosinsky, P; Scomparin, E; Seixas, J; Serci, S; Shahoyan, R; Sonderegger, P; Specht, H J; Tieulent, R; Usai, G; Veenhof, R; Whri, H K

    2009-01-01

    The yield of muon pairs in the invariant mass region 1158 A GeV In-In collisions. We furthermore observe, by tagging the dimuon vertices, that this excess is not due to enhanced D meson production, but made of {\\em prompt} muon pairs, as expected from a source of thermal dimuons specific to high-energy nucleus-nucleus collisions. The yield of this excess increases significantly from peripheral to central collisions, both with respect to the Drell-Yan yield and to the number of nucleons participating in the collisions. Furthermore, the transverse mass distributions of the excess dimuons are well described by an exponential function, with inverse slope values around 190 MeV. The...

  12. $K^{\\ast}(892)^0$ and $\\bar{K}^{\\ast}(892)^0$ production in central Pb+Pb, Si+Si, C+C and inelastic p+p collisions at 158$A$~GeV

    CERN Document Server

    Anticic, T.; Barna, D.; Bartke, J.; Beck, H.; Betev, L.; Bialkowska, H.; Blume, C.; Bogusz, M.; Boimska, B.; Book, J.; Botje, M.; Buncic, P.; Cetner, T.; Christakoglou, P.; Chung, P.; Chvala, O.; Cramer, J.G.; Eckardt, V.; Fodor, Z.; Foka, P.; Friese, V.; Gazdzicki, M.; Grebieszkow, K.; Hohne, C.; Kadija, K.; Karev, A.; Kolesnikov, V.I.; Kowalski, M.; Kresan, D.; Laszlo, A.; Lacey, R.; van Leeuwen, M.; Mackowiak, M.; Makariev, M.; Malakhov, A.I.; Mateev, M.; Melkumov, G.L.; Mitrovski, M.; Mrowczynski, S.; Nicolic, V.; Palla, G.; Panagiotou, A.D.; Peryt, W.; Pluta, J.; Prindle, D.; Puhlhofer, F.; Renfordt, R.; Roland, C.; Roland, G.; Rybczynski, M.; Rybicki, A.; Sandoval, A.; Schmitz, N.; Schuster, T.; Seyboth, P.; Sikler, F.; Skrzypczak, E.; Slodkowski, M.; Stefanek, G.; Stock, R.; Strobele, H.; Susa, T.; Szuba, M.; Utvic, M.; Varga, D.; Vassiliou, M.; Veres, G.I.; Vesztergombi, G.; Vranic, D.; Wlodarczyk, Z.; Wojtaszek-Szwarc, A.

    2011-01-01

    Production of the $K^{\\ast}(892)^0$ and $\\bar{K}^{\\ast}(892)^0$ resonances was studied via their $K^+ \\pi^-$ and $K^- \\pi^+$ decay modes in central Pb+Pb, Si+Si, C+C and inelastic p+p collisions at 158\\agev ($\\sqrt{s_{NN}}$ = 17.3 GeV) with the NA49 detector at the CERN SPS. Transverse momentum and rapidity distributions were measured and total yields were estimated. The yield of $K^{\\ast}$ exceeds that of $\\bar{K}^{\\ast}$ by about a factor of two in nucleus-nucleus reactions. The total yield ratios $/$ and $/$ are strongly suppressed in central Pb+Pb compared to p+p, C+C and Si+Si collisions in agreement with the expected attenuation of these short-lived resonance states in the hadronic phase of the expanding fireball. The UrQMD model, although incorporating such a scenario, does not provide a quantitative description of the experimental results. The statistical hadron gas model assuming the same freeze-out parameters for stable hadrons and resonances overestimates the $/$ ratios in central Pb+Pb collisions ...

  13. Voxelwise eigenvector centrality mapping of the human functional connectome reveals an influence of the catechol-O-methyltransferase val158met polymorphism on the default mode and somatomotor network.

    Science.gov (United States)

    Markett, Sebastian; Montag, Christian; Heeren, Behrend; Saryiska, Rayna; Lachmann, Bernd; Weber, Bernd; Reuter, Martin

    2016-06-01

    Functional connections between brain regions constitute the substrate of the human functional connectome, whose topography has been discussed as an endophenotype for psychiatric disorders. Genetic influences on the entire connectome, however, have been rarely investigated so far. We tested for connectome-wide influences of the val158met (rs4860) polymorphism on the catechol-O-methyltransferase (COMT) gene by applying formal network analysis and eigenvector centrality mapping on the voxel level to resting-state functional magnetic imaging data. This approach finds brain regions that are central in the network by aggregating local and global connectivity patterns, most importantly without the requirement to select regions or networks of interest. The COMT variant linked to high enzyme activity increased network centrality in distributed brain areas that are known to constitute the brain's default mode network. Further results also indicated a COMT influence on areas implicated in the somatomotor network. These findings are in line with the polymorphism's alleged role in cognitive processing and its role in psychotic disorders. The study is the first to demonstrate the influence of a functional and behaviorally relevant genetic variant on connectome-wide functional connectivity and is an important step toward establishing the functional connectome as an endophenotype for psychiatric and behavioral phenotypes.

  14. Publications | Page 158 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Analisis kebijakan dalam mengatasi kekurangan bidan desa di kabupaten Natuna (restricted access). Background: Geographical condition of Natuna Islands which is not in accordance with health development affects the quantity and availability of midwives distributed in villages in the District of Natuna. In fact, the ratio ...

  15. 14 CFR 158.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ...-for-the-price-of-one” and similar marketing programs, or to air transportation purchased for a.... Public agency means a State or any agency of one or more States; a municipality or other political...

  16. 33 CFR 158.120 - Definitions.

    Science.gov (United States)

    2010-07-01

    ..., damage amenities or interfere with other legitimate uses of the sea, and includes any substance subject... issued under 46 CFR 153.900(d). Oceangoing ship means a ship that— (1) Is operated under the authority of the United States and engages in international voyages; (2) Is operated under the authority of the...

  17. BDML Metadata: 158 [SSBD[Archive

    Lifescience Database Archive (English)

    Full Text Available Ce_KK_P002 BDML file for quantitative information about nuclear division dynamics o...f R08D7.2(RNAi) embryo quantitative information about nuclear division dynamics in R08D7.2(RNAi) embryo C. e...legans nuclear division dynamics R08D7.2(gPCR)040812_01 Measurement Kyoda, K., Furukawa, M., Arai, R., Onami

  18. 21 CFR 158.170 - Frozen peas.

    Science.gov (United States)

    2010-04-01

    ... the words “frozen” or “quick frozen”. The name of the food shall include a declaration of any... paragraph (a)(2) of this section or the applicable sieve size. However, the optional descriptive words..., specified in paragraph (b)(3)(i) (a) or (b) of this section, diluted to 9.5 liters with water). (iii) Drying...

  19. Publications | Page 158 | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Physico-chemical characteristics and fatty acid profile of desert date kernel oil in Uganda (open access). Because of its importance as a source of food and income for dryland communities, an assessment of the physico-chemical characteristics and fatty acid profile of kernel oil was carried out. Both the fruits and oil are trade ...