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Sample records for terbium 150

  1. Elastic properties of terbium

    DEFF Research Database (Denmark)

    Spichkin, Y.I.; Bohr, Jakob; Tishin, A.M.

    1996-01-01

    The temperature dependence of the Young modulus along the crystallographic axes b and c (E(b) and E(c)), and the internal friction of a terbium single crystal have been measured. At 4.2 K, E(b) and E(c) are equal to 38 and 84.5 GPa, respectively. The lattice part of the Young modulus and the Debye...... temperature has been calculated. The origin of the Young modulus anomalies arising at the transition to the magnetically ordered state is discussed....

  2. Terbium luminescence in alumina xerogel fabricated in porous anodic alumina matrix under various excitation conditions

    Energy Technology Data Exchange (ETDEWEB)

    Gaponenko, N. V., E-mail: nik@nano.bsuir.edu.by [Belarusian State University of Informatics and Radioelectronics (Belarus); Kortov, V. S. [Yeltsin Ural Federal University (Russian Federation); Orekhovskaya, T. I.; Nikolaenko, I. A. [Belarusian State University of Informatics and Radioelectronics (Belarus); Pustovarov, V. A.; Zvonarev, S. V.; Slesarev, A. I. [Yeltsin Ural Federal University (Russian Federation); Prislopski, S. Ya. [National Academy of Sciences of Belarus, Stepanov Institute of Physics (Belarus)

    2011-07-15

    Terbium-doped alumina xerogel layers are synthesized by the sol-gel method in pores of a porous anodic alumina film 1 {mu}m thick with a pore diameter of 150-180 nm; the film is grown on a silicon substrate. The fabricated structures exhibit terbium photoluminescence with bands typical of trivalent terbium terms. Terbium X-ray luminescence with the most intense band at 542 nm is observed for the first time for such a structure. Morphological analysis of the structure by scanning electron microscopy shows the presence of xerogel clusters in pore channels, while the main pore volume remains unfilled and pore mouths remain open. The data obtained confirm the promising applications of fabricated structures for developing matrix converters of X-rays and other ionizing radiations into visible light. The possibilities of increasing luminescence intensity in the matrix converter are discussed.

  3. Femtosecond XUV spectroscopy of gadolinium and terbium

    Energy Technology Data Exchange (ETDEWEB)

    Carley, Robert; Frietsch, Bjoern; Doebrich, Kristian; Teichmann, Martin; Gahl, Cornelius; Noack, Frank [Max-Born-Institute, Berlin (Germany); Schwarzkopf, Olaf; Wernet, Philippe [Helmholtz-Zentrum fuer Materialien und Energie (BESSY II), Berlin (Germany); Weinelt, Martin [Max-Born-Institute, Berlin (Germany); Fachbereich Physik, Freie Universitaet, Berlin (Germany)

    2011-07-01

    We present recent results of time-resolved IR-pump-XUV-probe experiments on the ultrafast demagnetization of thin films of Gadolinium(0001) and Terbium(0001) on Tungsten(110). The experiments are the first to be done using a newly developed high-order harmonics (HHG) XUV beamline at the MBI. The beamline delivers monochromated XUV pulses of approximately 150 fs duration with a photon energy resolution of up to 150 meV. Following excitation by intense femtosecond infrared (IR) pulses, photoemission with 35 eV photons allows us to directly probe the 4f electrons and their interaction with the valence band, both in the bulk and at the surface, to follow the ultrafast magnetization dynamics in the Lanthanide metals. As signatures of ultrafast demagnetization of the metal by the IR pulse, we see for the first time, rapid strong reduction of the exchange splitting in the valence band. This is followed by a slower demagnetization due to the spin-lattice interaction.

  4. Critical scattering of neutrons from terbium

    DEFF Research Database (Denmark)

    Als-Nielsen, Jens Aage; Dietrich, O.W.; Marshall, W.

    1968-01-01

    The inelasticity of the critical scattering of neutrons in terbium has been measured above the Neél temperature at the (0, 0, 2−Q) satellite position. The results show that dynamic slowing down of the fluctuations does occur in a second‐order phase transition in agreement with the general theory...

  5. Semiconductor composition containing iron, dysprosium, and terbium

    Energy Technology Data Exchange (ETDEWEB)

    Pooser, Raphael C.; Lawrie, Benjamin J.; Baddorf, Arthur P.; Malasi, Abhinav; Taz, Humaira; Farah, Annettee E.; Kalyanaraman, Ramakrishnan; Duscher, Gerd Josef Mansfred; Patel, Maulik K.

    2017-09-26

    An amorphous semiconductor composition includes 1 to 70 atomic percent iron, 15 to 65 atomic percent dysprosium, 15 to 35 atomic percent terbium, balance X, wherein X is at least one of an oxidizing element and a reducing element. The composition has an essentially amorphous microstructure, an optical transmittance of at least 50% in at least the visible spectrum and semiconductor electrical properties.

  6. DFDS 150

    OpenAIRE

    Peter, Bruce

    2015-01-01

    This output is a 143,000 word business, technical, design and operational history of Det Forenede Dampskibs-Selskab (DFDS), one of the world’s oldest commercial shipping companies which is 150 years old in 2016. The publisher is Polyteknisk Laeranstalts Forlag, the publishing arm of the Technical University of Denmark (DTU), under whose Nautilus Forlag imprint the book is marketed. Since its establishment, DFDS has made a very substantial contribution to the economy and culture of Denmark and...

  7. Raman spectroscopy study of the doping effect of the encapsulated terbium halogenides on single-walled carbon nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Kharlamova, M.V.; Kramberger, C.; Mittelberger, A. [University of Vienna, Faculty of Physics, Vienna (Austria)

    2017-04-15

    In the present work, the doping effect of terbium chloride, terbium bromide, and terbium iodide on single-walled carbon nanotubes (SWCNTs) was compared by Raman spectroscopy. A precise investigation of the doping-induced alterations of the Raman modes of the filled SWCNTs was conducted. The shifts of the components of the Raman modes and modification of their profiles allowed concluding that the inserted terbium halogenides have acceptor doping effect on the SWCNTs, and the doping efficiency increases in the line with terbium iodide, terbium bromide, and terbium chloride. (orig.)

  8. Magnetocaloric effect of thin Terbium films

    Science.gov (United States)

    Mello, V. D.; Anselmo, D. H. A. L.; Vasconcelos, M. S.; Almeida, N. S.

    2017-12-01

    We report a theoretical study of the magnetocaloric effect of Terbium (Tb) thin films due to finite size and surface effects in the helimagnetic phase, corresponding to a temperature range from TC=219 K to TN=231 K, for external fields of the order of kOe. For a Tb thin film of 6 monolayers submitted to an applied field (ΔH =30 kOe, ΔH =50 kOe and ΔH = 70 kOe) we report a significative change in adiabatic temperature, ΔT / ΔH , near the Néel temperature, of the order ten times higher than that observed for Tb bulk. On the other hand, for small values of the magnetic field, large thickness effects are found. For external field strength around few kOe, we have found that the thermal caloric efficiency increases remarkably for ultrathin films. For an ultrathin film with 6 monolayers, we have found ΔT / ΔH = 43 K/T while for thicker films, with 20 monolayers, ΔT / ΔH = 22 K/T. Our results suggest that thin films of Tb are a promising material for magnetocaloric effect devices for applications at intermediate temperatures.

  9. Green fluorescence of terbium ions in lithium fluoroborate glasses ...

    Indian Academy of Sciences (India)

    Glasses; terbium ion; oscillator strengths; fluorescence; lifetimes; fibre lasers. 1. Introduction. Today glasses are most favourable engineering materials for abundant applications due to the wide ability of property altering by compositional modifications. The considerable examination of glass science to achieve required ...

  10. Green fluorescence of terbium ions in lithium fluoroborate glasses ...

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science; Volume 39; Issue 3. Green fluorescence of terbium ions in lithium fluoroborate glasses for fibre lasers and display devices. G R DILLIP C MADHUKAR REDDY M RAJESH SHIVANAND CHAURASIA B DEVA PRASAD RAJU S W JOO. Volume 39 Issue 3 June 2016 pp 711-717 ...

  11. Terahertz Cherenkov radiation from ultrafast magnetization in terbium gallium garnet

    Science.gov (United States)

    Gorelov, S. D.; Mashkovich, E. A.; Tsarev, M. V.; Bakunov, M. I.

    2013-12-01

    We report an experimental observation of terahertz Cherenkov radiation from a moving magnetic moment produced in terbium gallium garnet by a circularly polarized femtosecond laser pulse via the inverse Faraday effect. Contrary to some existing theoretical predictions, the polarity of the observed radiation unambiguously demonstrates the paramagnetic, rather than diamagnetic, nature of the ultrafast inverse Faraday effect. From measurements of the radiation field, the Verdet constant in the subpicosecond regime is ˜3-10 times smaller than its table quasistatic value.

  12. Optical Properties of Lithium Terbium Fluoride and Implications for Performance in High Power Lasers (Postprint)

    Science.gov (United States)

    2016-02-01

    AFRL-RX-WP-JA-2016-0323 OPTICAL PROPERTIES OF LITHIUM TERBIUM FLUORIDE AND IMPLICATIONS FOR PERFORMANCE IN HIGH POWER LASERS... AMERICA (STINFO COPY) AIR FORCE RESEARCH LABORATORY MATERIALS AND MANUFACTURING DIRECTORATE WRIGHT-PATTERSON AIR FORCE BASE, OH 45433-7750 AIR...OPTICAL PROPERTIES OF LITHIUM TERBIUM FLUORIDE AND IMPLICATIONS FOR PERFORMANCE IN HIGH POWER LASERS (POSTPRINT) 5a. CONTRACT NUMBER IN-HOUSE 5b

  13. Detection of biothiols in cells by a terbium chelate-Hg (II) system

    Science.gov (United States)

    Tan, Hongliang; Chen, Yang

    2012-01-01

    Great efforts have been devoted to the development of sensitive and specific analysis methods for biothiols because of their important roles in biological systems. We present a new detection system for biothiols that is based on the reversible quenching and restoration of fluorescence of terbium chelate caused by Hg2+ and thiol species. In the presence of biothiols, a restoration of fluorescence of terbium chelate after quenching by Hg2+ was observed due to the interaction of Hg2+ with thiol groups, and the restored fluorescence increased with the concentration of biothiols. This method was sensitive and selective for biothiols. The detection limit was 80 nM for glutathione, 100 nM for Hcy, and 400 nM for Cysteine, respectively. The terbium chelate-Hg (II) system was successfully applied to determine the levels of biothiols in cancer cells and urine samples. Further, it was also shown to be comparable to Ellman's assay. Compared to other fluorescence methods, the terbium chelate probe is advantageous because interference from short-lived nonspecific fluorescence can be efficiently eliminated due to the long fluorescence lifetime of terbium chelate, which allows for detection by time-resolved fluorescence. The terbium chelate probe can serve as a diagnostic tool for the detection of abnormal levels of biothiols in disease.

  14. Cryogenic temperature characteristics of Verdet constant of terbium sesquioxide ceramics

    Science.gov (United States)

    Snetkov, I. L.; Palashov, O. V.

    2016-12-01

    The dependence of the Verdet constant on temperature in the (80-300 K) range for a promising magneto-active material terbium sesquioxide Tb2O3 at the wavelengths of 405-1064 nm is considered. For each of the studied wavelengths, the Verdet constant of the material cooled down to the liquid nitrogen temperature increased by more than a factor of 3.2 as compared to the room temperature value. Similarly to the other paramagnetics, the increase follows the law ∼1/T. Approximations for the temperature dependence of the Verdet constant have been obtained and the value of 1/V·(dV/dT) has been estimated. This information is needed to determine the angle of rotation as well as the variation of the extinction ratio of a Faraday isolator with temperature and extremely important at creation a cryogenic Faraday devices.

  15. Biogenic terbium oxide nanoparticles as the vanguard against osteosarcoma

    Science.gov (United States)

    Iram, Sana; Khan, Salman; Ansary, Abu Ayoobul; Arshad, Mohd; Siddiqui, Sahabjada; Ahmad, Ejaz; Khan, Rizwan H.; Khan, Mohd Sajid

    2016-11-01

    The synthesis of inner transition metal nanoparticles via an ecofriendly route is quite difficult. This study, for the first time, reports synthesis of terbium oxide nanoparticles using fungus, Fusarium oxysporum. The biocompatible terbium oxide nanoparticles (Tb2O3 NPs) were synthesized by incubating Tb4O7 with the biomass of fungus F. oxysporum. Multiple physical characterization techniques, such as UV-visible and photoluminescence spectroscopy, TEM, SAED, and zeta-potential were used to confirm the synthesis, purity, optical and surface characteristics, crystallinity, size, shape, distribution, and stability of the nanoemulsion of Tb2O3 NPs. The Tb2O3 NPs were found to inhibit the propagation of MG-63 and Saos-2 cell-lines (IC50 value of 0.102 μg/mL) and remained non-toxic up to a concentration of 0.373 μg/mL toward primary osteoblasts. Cell viability decreased in a concentration-dependent manner upon exposure to 10 nm Tb2O3 NPs in the concentration range 0.023-0.373 μg/mL. Cell toxicity was evaluated by observing changes in cell morphology, cell viability, oxidative stress parameters, and FACS analysis. Morphological examinations of cells revealed cell shrinkage, nuclear condensation, and formation of apoptotic bodies. The level of ROS within the cells-an indicator of oxidative stress was significantly increased. The induction of apoptosis at concentrations ≤ IC50 was corroborated by 4‧,6-diamidino-2-phenylindole dihydrochloride (DAPI) staining (DNA damage and nuclear fragmentation). Flow-cytometric studies indicated that the response was dose dependent with a threshold effect.

  16. Autofluorescence-free Live-cell Imaging Using Terbium Nanoparticles.

    Science.gov (United States)

    Cardoso Dos Santos, Marcelina; Goetz, Joan; Bartenlian, Hortense; Wong, Ka-Leung; Charbonniere, Loïc Joanny; Hildebrandt, Niko

    2018-02-20

    Fluorescent nanoparticles (NPs) have become irreplaceable tools for advanced cellular and sub-cellular imaging. While very bright NPs require excitation with UV or visible light, which can create strong autofluorescence of biological components, NIR-excitable NPs without autofluorescence issues exhibit much lower brightness. Here, we show the application of a new type of surface-photosensitized terbium NPs (Tb-NPs) for autofluorescence-free intracellular imaging in live HeLa cells. Combination of exceptionally high brightness, high photostability, and long photoluminecence (PL) lifetimes for highly efficient suppression of the short-lived autofluorescence, allowed for time-gated PL imaging of intracellular vesicles over 72 h without toxicity and at extremely low Tb-NP concentrations down to 12 pM. Detection of highly resolved long-lifetime (ms) PL decay curves from small (~10 µm2) areas within single cells within a few seconds emphasized the unprecedented photophysical properties of Tb-NPs for live-cell imaging that extend well beyond currently available nanometric imaging agents.

  17. Solar Thermochemical Hydrogen Production via Terbium Oxide Based Redox Reactions

    Directory of Open Access Journals (Sweden)

    Rahul Bhosale

    2016-01-01

    Full Text Available The computational thermodynamic modeling of the terbium oxide based two-step solar thermochemical water splitting (Tb-WS cycle is reported. The 1st step of the Tb-WS cycle involves thermal reduction of TbO2 into Tb and O2, whereas the 2nd step corresponds to the production of H2 through Tb oxidation by water splitting reaction. Equilibrium compositions associated with the thermal reduction and water splitting steps were determined via HSC simulations. Influence of oxygen partial pressure in the inert gas on thermal reduction of TbO2 and effect of water splitting temperature (TL on Gibbs free energy related to the H2 production step were examined in detail. The cycle (ηcycle and solar-to-fuel energy conversion (ηsolar-to-fuel efficiency of the Tb-WS cycle were determined by performing the second-law thermodynamic analysis. Results obtained indicate that ηcycle and ηsolar-to-fuel increase with the decrease in oxygen partial pressure in the inert flushing gas and thermal reduction temperature (TH. It was also realized that the recuperation of the heat released by the water splitting reactor and quench unit further enhances the solar reactor efficiency. At TH=2280 K, by applying 60% heat recuperation, maximum ηcycle of 39.0% and ηsolar-to-fuel of 47.1% for the Tb-WS cycle can be attained.

  18. Folate Receptor Targeted Alpha-Therapy Using Terbium-149

    CERN Document Server

    Müller, Cristina; Haller, Stephanie; Dorrer, Holger; Köster, Ulli; Johnston, Karl; Zhernosekov, Konstantin; Türler, Andreas; Schibli, Roger

    2014-01-01

    Terbium-149 is among the most interesting therapeutic nuclides for medical applications. It decays by emission of short-range α-particles (Eα = 3.967 MeV) with a half-life of 4.12 h. The goal of this study was to investigate the anticancer efficacy of a 149Tb-labeled DOTA-folate conjugate (cm09) using folate receptor (FR)-positive cancer cells in vitro and in tumor-bearing mice. 149Tb was produced at the ISOLDE facility at CERN. Radiolabeling of cm09 with purified 149Tb resulted in a specific activity of ~1.2 MBq/nmol. In vitro assays performed with 149Tb-cm09 revealed a reduced KB cell viability in a FR-specific and activity concentration-dependent manner. Tumor-bearing mice were injected with saline only (group A) or with 149Tb-cm09 (group B: 2.2 MBq; group C: 3.0 MBq). A significant tumor growth delay was found in treated animals resulting in an increased average survival time of mice which received 149Tb-cm09 (B: 30.5 d; C: 43 d) compared to untreated controls (A: 21 d). Analysis of blood parameters rev...

  19. Hardness and dielectric characteristics of flux grown terbium aluminate crystals

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, K.K.; Kotru, P.N. [Jammu Univ. (India). Dept. of Physics; Tandon, R.P. [National Physical Laboratory, New Delhi (India); Wanklyn, B.M. [Clarendon Laboratory, University of Oxford, Oxford (United Kingdom)

    1999-01-29

    Results of indentation induced Vickers hardness testing and dielectric studies conducted on flux-grown terbium aluminate crystals are presented. It is shown that the Vickers hardness value (H{sub v}) is independent of indentation time, but depends on the applied load. Applying the concept of Hays and Kendall, the load independent values are estimated for (110) and (001) planes. Differential behaviour in the crack formation of two different planes (110) and (001) is observed, while (001) plane develops Palmqvist cracks in the whole load range of 10-100 g, (110) plane shows a transition from Palmqvist to median cracks at 70 g. The fracture toughness, brittleness index and yield strength are determined for both the planes. The hardness anisotropy is reported. The dielectric constant, dielectric loss and conductivity are shown to be dependent on temperature and frequency of the applied a.c. field. The dielectric constant versus temperature shows a transition peak at 230 C, which remains independent of the frequency of the applied a.c. field in the range 1 kHz-13 MHz. (orig.) 36 refs.

  20. 150 years of science

    Directory of Open Access Journals (Sweden)

    Francesca Messina

    2011-08-01

    Full Text Available This preview of the Festival della Scienza 2011 focuses on a major initiative celebrating 150 years of Italian scientific research. Run jointly by the Italian Research Council (CNR and the Associazione Festival della Scienza, the project presents outstanding achievements in various fields including neuroscience, web technologies, genetics, chemistry and much more.

  1. 150 aastat papa Jannsenist

    Index Scriptorium Estoniae

    2007-01-01

    2007. a. möödub 150 aastat Johann Voldemar Jannseni asutatud Pärnu Postimehe 1. numbri ilmumisest. Selle tähistamiseks avatakse Pärnus Rüütli tänava muulil 5. juunil 2007 Jannseni kuju (skulptor Mati Karmin)

  2. Thermoluminescence of cerium and terbium -doped calcium pyrophosphate

    Energy Technology Data Exchange (ETDEWEB)

    Roman L, J.; Cruz Z, E. [UNAM, Instituto de Ciencias Nucleares, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Lozano R, I. B.; Diaz G, J. A. I., E-mail: jesus.roman@nucleares.unam.mx [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria No. 694, 11500 Mexico D. F. (Mexico)

    2015-10-15

    The aim of this work is to report the thermoluminescence (Tl) response of Calcium Pyrophosphate phosphor doped with Cerium and Terbium impurities (Ca{sub 2}P{sub 2}O{sub 7}:Ce{sup 3+},Tb{sup 3+}). The phosphors were synthesized using the co-precipitation method and annealed at 900 degrees C by two hours for obtain the β phase. The intentional doping with Ce and Tb ions was 1 at.% and 0.1 at.%, whereas in the EDS results the concentration of impurities was 0.39 at.% and 0.05 at.%, respectively. The superficial morphology of phosphor is mainly composed by thin wafers of different size. All samples were exposed to gamma rays from {sup 60}Co in the Gammacell-200 irradiator. The Tl response of the phosphor was measured from Rt up to 350 degrees C and under nitrogen atmosphere in a Harshaw TLD 3500 reader. The glow curves of the Ca{sub 2}P{sub 2}O{sub 7}:Ce{sup 3+},Tb{sup 3+} powders showed a broad intense Tl peak centered at 165 degrees C and a shoulder at approximate 260 degrees C was observed. A linear Tl response in the range of absorbed dose of 0.2 to 10 Gy was obtained. Tl glow curves were analyzed using the initial rise (IR)and computerized glow curve deconvolution methods to evaluate the kinetics parameters such as activation energy (E), frequency factor (s) and kinetic order (b). (Author)

  3. Solvent polarity and oxygen sensitivity, rather than viscosity, determine lifetimes of biaryl-sensitised terbium luminescence.

    Science.gov (United States)

    Walter, Edward R H; Williams, J A Gareth; Parker, David

    2017-12-14

    In a macrocyclic terbium complex incorporating a biaryl sensitiser, the observed variation of emission lifetime is shown to be determined by the solubility of oxygen in the solvent system and the relative energy of the chromophore excited state, rather than any dependence on solvent viscosity.

  4. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Exceptions to the compatibility chart. 150.150 Section... CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (G-MSO... 1, the Compatibility Chart. ...

  5. Arginine-responsive terbium luminescent hybrid sensors triggered by two crown ether carboxylic acids

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Lasheng [Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); Tang, Ke; Ding, Xiaoping [School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); Wang, Qianming, E-mail: qmwang@scnu.edu.cn [Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China); Zhou, Zhan; Xiao, Rui [School of Chemistry and Environment, South China Normal University, Guangzhou 510006 (China)

    2013-12-01

    Crown ether carboxylic acids constitute main building blocks for the synthesis of terbium containing covalent cross-linked luminescent materials. Both the complexes and the hybrid nanomaterials could exhibit remarkable green emissions in pure water. More importantly, they were found to have a profound effect on the luminescence responses to arginine compared with glutamic acid, histidine, tryptophan, threonine, tyrosine and phenylalanine in aqueous environment. The present study provided the possibility of using a host–guest mechanism as a way of signal transduction based on lanthanide supramolecular hybrid materials. - Highlights: • Crown ether carboxylic acids were found to sensitize terbium ions among a group of ethers. • The complexes and silica hybrid materials were both prepared and characterized. • They could exhibit remarkable green emissions in pure water.

  6. Comparative analysis of conjugated alkynyl chromophore-triazacyclononane ligands for sensitized emission of europium and terbium.

    Science.gov (United States)

    Soulié, Marine; Latzko, Frédéric; Bourrier, Emmanuel; Placide, Virginie; Butler, Stephen J; Pal, Robert; Walton, James W; Baldeck, Patrice L; Le Guennic, Boris; Andraud, Chantal; Zwier, Jurriaan M; Lamarque, Laurent; Parker, David; Maury, Olivier

    2014-07-07

    A series of europium and terbium complexes based on a functionalized triazacyclononane carboxylate or phosphinate macrocyclic ligand is described. The influence of the anionic group, that is, carboxylate, methylphosphinate, or phenylphosphinate, on the photophysical properties was studied and rationalized on the basis of DFT calculated structures. The nature, number, and position of electron-donating or electron-withdrawing aryl substituents were varied systematically within the same phenylethynyl scaffold in order to optimize the brightness of the corresponding europium complexes and investigate their two-photon absorption properties. Finally, the europium complexes were examined in cell-imaging applications, and selected terbium complexes were studied as potential oxygen sensors. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Spectrofluorimetric Determination of Human Serum Albumin Using Terbium-Danofloxacin Probe

    OpenAIRE

    Ramezani, Amir M.; Manzoori, Jamshid L.; Amjadi, Mohammad; Jouyban, Abolghasem

    2012-01-01

    A spectrofluorimetric method is proposed for the determination of human serum albumin (HSA) and bovine serum albumin (BSA) using terbium-danofloxacin (Tb3+-Dano) as a fluorescent probe. These proteins remarkably enhance the fluorescence intensity of the Tb3+-Dano complex at 545 nm, and the enhanced fluorescence intensity of Tb3+-Dano is proportional to the concentration of proteins (HSA and BSA). Optimum conditions for the determination of HSA were investigated and found that the maximum resp...

  8. Genetically Encoded FRET-Sensor Based on Terbium Chelate and Red Fluorescent Protein for Detection of Caspase-3 Activity

    Directory of Open Access Journals (Sweden)

    Alexander S. Goryashchenko

    2015-07-01

    Full Text Available This article describes the genetically encoded caspase-3 FRET-sensor based on the terbium-binding peptide, cleavable linker with caspase-3 recognition site, and red fluorescent protein TagRFP. The engineered construction performs two induction-resonance energy transfer processes: from tryptophan of the terbium-binding peptide to Tb3+ and from sensitized Tb3+ to acceptor—the chromophore of TagRFP. Long-lived terbium-sensitized emission (microseconds, pulse excitation source, and time-resolved detection were utilized to eliminate directly excited TagRFP fluorescence and background cellular autofluorescence, which lasts a fraction of nanosecond, and thus to improve sensitivity of analyses. Furthermore the technique facilitates selective detection of fluorescence, induced by uncleaved acceptor emission. For the first time it was shown that fluorescence resonance energy transfer between sensitized terbium and TagRFP in the engineered construction can be studied via detection of microsecond TagRFP fluorescence intensities. The lifetime and distance distribution between donor and acceptor were calculated using molecular dynamics simulation. Using this data, quantum yield of terbium ions with binding peptide was estimated.

  9. Green light emission in aluminum oxide powders doped with different terbium concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Mariscal B, L; Falcony, C. [IPN, Centro de Investigacion y de Estudios Avanzados, 07360 Ciudad de Mexico (Mexico); Carmona T, S.; Murrieta, H.; Sanchez A, M. A. [UNAM, Instituto de Fisica, 04510 Ciudad de Mexico (Mexico); Vazquez A, R. [IPN, Escuela Superior de Computo, 07738 Ciudad de Mexico (Mexico); Garcia R, C. M., E-mail: mariscal2005@gmail.com [UNAM, Facultad de Ciencias, 04510 Ciudad de Mexico (Mexico)

    2016-11-01

    Different emission intensities presented in aluminum oxide phosphors corresponding to different concentrations of doping performed with terbium are analyzed. The phosphors were synthesized by the evaporation technique and were characterized by photo and cathodoluminescence, X-ray diffraction and EDS techniques for different incorporation percentages of terbium as dopant; they show characteristic transitions in 494, 543, 587 and 622 nm, corresponding to {sup 5}D{sub 4} → {sup 7}F{sub 6}, {sup 5}D{sub 4} → {sup 7}F{sub 5}, {sup 5}D{sub 4} → {sup 7}F{sub 4} and {sup 5}D{sub 4} → {sup 7}F{sub 3}, respectively when they are excited with λ{sub exc} = 380 nm wavelength at room temperature. The results of X-ray diffraction show the presence of α-Al{sub 2}O{sub 3} phases with peaks located at 2θ = 25.78, 35.34, 37.96, 43.56, 45.8, 52.74, 57.7, 61.5, 66.74, 68.44, 77.12 and 80.94, and the δ-Al{sub 2}O-3 phase 2θ = 32.82, 45.8, 61.36 and 66.74. These compounds were heat treated for two hours at 1100 degrees Celsius. EDS analyzes indicate that these compounds have close to 60% oxygen around of 40% aluminum in the presence of terbium as dopant which indicates a stoichiometry close to the expected one for alumina. (Author)

  10. Graphene quantum dots-terbium ions as novel sensitive and selective time-resolved luminescent probes.

    Science.gov (United States)

    Llorent-Martínez, Eulogio J; Durán, Gema M; Ríos, Ángel; Ruiz-Medina, Antonio

    2018-01-01

    We propose an alternative approach for the development of analytical methods based on terbium-sensitized luminescence (TSL). TSL is based on the complexation between Tb(III) ions and fluorescent organic compounds that have appropriate functional groups to complex with Tb(III). We report the use of graphene quantum dot (GQDs) nanoparticles to improve the sensitivity and selectivity of TSL detection. GQDs can react with terbium ions through the carboxylic groups present in their structure. These Tb(III)-GQD complexes, formed in situ in aqueous solution, can be used as time-resolved luminescent probes. Ascorbic acid was selected as a target analyte to demonstrate the suitability of the proposed method. The selectivity of the TSL method was highly improved for most of the interferences tested. Under the optimum conditions [Tb(III) concentration 5 × 10-4 mol L-1, GQD concentration 4 mg L-1], a minimum 100% increase in selectivity was observed for several vitamins and common cations that may be present in the samples to be analyzed. In addition, the analytical signal showed a 30% enhancement with the use of GQDs compared with the use of merely Tb(III) ions, with a detection limit of 0.12 μg mL-1. The repeatability and intermediate precision were lower than 3% and 5%, respectively. From the results obtained, the implementation of GQDs in TSL can lead to the development of novel time-resolved luminescent probes with high analytical potential. Graphical abstract Quenching of Tb(III)-graphene quantum dot (GQD) luminescence by ascorbic acid (AA). TBL terbium-sensitized luminescence.

  11. Fluorescence study of some terbium-oligopeptide complexes in methanolic solution.

    Science.gov (United States)

    Rabouan, S; Delage, J; Durand, W; Prognon, P; Barthes, D

    2000-04-03

    This study concerned the use of lanthanide chelates to detect glycyl-leucyl-phenylalanine (GLF) and its homologues. Spectroscopic analysis of peptides without or with terbium complexation revealed the formation of (LF)(3)(Tb)(2), (GF)(3)(Tb)(2), (GLF)(3)(Tb)(2) and (FL)(4)Tb, (FG)(4)Tb complexes with high stability constants in methanolic solutions (pK(d)>13). Lanthanide chelate emission displayed a large Stokes shift (>270 nm), which allowed Tb chelates of GLF and its derivatives to be used for detection purposes. However, this preliminary study indicated some important limitations associated with lanthanide chelation, such as high methanolic content.

  12. Electromagnetic properties of terbium gallium garnet at millikelvin temperatures and low photon energy

    Science.gov (United States)

    Kostylev, Nikita; Goryachev, Maxim; Bushev, Pavel; Tobar, Michael E.

    2017-07-01

    Electromagnetic properties of single crystal terbium gallium garnet are characterised from room down to millikelvin temperatures using the whispering gallery mode method. Microwave spectroscopy is performed at low powers equivalent to a few photons in energy and conducted as functions of the magnetic field and temperature. A phase transition is detected close to the temperature of 3.5 K. This is observed for multiple whispering gallery modes causing an abrupt negative frequency shift and a change in transmission due to extra losses in the new phase caused by a change in complex magnetic susceptibility.

  13. Nuclear excitation functions from 40 to 200 MeV proton irradiation of terbium

    Energy Technology Data Exchange (ETDEWEB)

    Engle, Jonathan W., E-mail: jwengle@lanl.gov; Mashnik, Stepan G.; Parker, Lauren A.; Jackman, Kevin R.; Bitteker, Leo J.; Ullmann, John L.; Gulley, Mark S.; Pillai, Chandra; John, Kevin D.; Birnbaum, Eva R.; Nortier, Francois M.

    2016-01-01

    Nuclear formation cross sections are reported for 26 radionuclides, measured with 40–200 MeV proton irradiations of terbium foils. These data provide the basis for the production of medically relevant radionuclides (e.g., {sup 152}Tb, {sup 155}Tb, {sup 155}Eu, and {sup 156}Eu) and {sup 153}Gd, a potential source used in ongoing efforts to characterize stellar nucleosynthesis routes. Computational predictions from the ALICE2011, CEM03.03, Bertini, and INCL + ABLA codes are compared with newly measured data to contribute to the ongoing process of code development, and yields are calculated for selected radionuclides using measured data.

  14. Micelle-enhanced and terbium-sensitized spectrofluorimetric determination of gatifloxacin and its interaction mechanism

    Science.gov (United States)

    Guo, Changchuan; Wang, Lei; Hou, Zhun; Jiang, Wei; Sang, Lihong

    2009-05-01

    A terbium-sensitized spectrofluorimetric method using an anionic surfactant, sodium dodecyl benzene sulfonate (SDBS), was developed for the determination of gatifloxacin (GFLX). A coordination complex system of GFLX-Tb 3+-SDBS was studied. It was found that SDBS significantly enhanced the fluorescence intensity of the complex (about 11-fold). Optimal experimental conditions were determined as follows: excitation and emission wavelengths of 331 and 547 nm, pH 7.0, 2.0 × 10 -4 mol l -1 terbium (III), and 2.0 × 10 -4 mol l -1 SDBS. The enhanced fluorescence intensity of the system (Δ If) showed a good linear relationship with the concentration of GFLX over the range of 5.0 × 10 -10 to 5.0 × 10 -8 mol l -1 with a correlation coefficient of 0.9996. The detection limit (3 σ) was determined as 6.0 × 10 -11 mol l -1. This method has been successfully applied to the determination of GFLX in pharmaceuticals and human urine/serum samples. Compared with most of other methods reported, the rapid and simple procedure proposed in the text offers higher sensitivity, wider linear range, and better stability. The interaction mechanism of the system is also studied by the research of ultraviolet absorption spectra, surface tension, solution polarity and fluorescence polarization.

  15. Circularly Polarized Luminescence in Enantiopure Europium and Terbium Complexes with Modular, All-Oxygen Donor Ligands

    Science.gov (United States)

    Seitz, Michael; Do, King; Ingram, Andrew J.; Moore, Evan G.; Muller, Gilles; Raymond, Kenneth N.

    2009-01-01

    Abstract: Circulaly polarized luminescence from terbium(III) complexed and excited by chiral antenna ligands gives strong emission The modular synthesis of three new octadentate, enantiopure ligands are reported - one with the bidentate chelating unit 2-hydroxyisophthalamide (IAM) and two with 1-hydroxy-2-pyridinone (1,2-HOPO) units. A new design principle is introduced for the chiral, non-racemic hexamines which constitute the central backbones for the presented class of ligands. The terbium(III) complex of the IAM ligand, as well as the europium(III) complexes of the 1,2-HOPO ligands are synthesized and characterized by various techniques (NMR, UV, CD, luminescence spectroscopy). All species exhibit excellent stability and moderate to high luminescence efficiency (quantum yields ΦEu = 0.05–0.08 and ΦTb = 0.30–0.57) in aqueous solution at physiological pH. Special focus is put onto the properties of the complexes in regard to circularly polarized luminescence (CPL). The maximum luminescence dissymmetry factors (glum) in aqueous solution are high with |glum|max = 0.08 – 0.40. Together with the very favorable general properties (good stability, high quantum yields, long lifetimes), the presented lanthanide complexes can be considered as good candidates for analytical probes based on CPL in biologically relevant environments. PMID:19639983

  16. B 150 civil engineering futures

    DEFF Research Database (Denmark)

    Foreword B150 –Civil Engineering Futures consists of interviews made, articles written, and projects presented in connection with the 150th anniversary celebrations of the study of civil engineering in Denmark. Instead of a historical retrospect, it was decided to look into the future. What...... challenges will the next 150 years bring civil engineers? Researchers and lecturers at DTU’s Department of Civil Engineering (known as DTU Byg) suggested possible events, and we also consulted civil engineers and their business partners in the building industry. In this way, a programme was put together...... theme in twentieth century architecture. Together, civil engineer Peter Rice and architect Ian Ritchie created a paradigm shift with their revolutionary ideas for glass facades supported by cables. Glued and bolted constructions made entirely of glass are now a reality in small-scale projects, yet...

  17. Luminescent method of determination of composition of europium and terbium complexes in solution by change of intensity ratio of luminescence bands

    Energy Technology Data Exchange (ETDEWEB)

    Bel' tyukova, S.V.; Nazarenko, N.A.; Poluehktov, N.S.

    1982-03-01

    The complexes of europium and terbium with phenanthroline, ethylenediaminetetraacetate, nitrilotriacetate, some acids-phenol derivatives and ..beta..-diketones series have been used as an example to demonstrate that the value of the ratio of intensities on the two bands of europium(terbium) luminescence spectra - the one corresponding to the hypersensitive'' transition and the other, to the magnetic dipole one - can be used for determination of the complexes composition in solutions.

  18. B 150 civil engineering futures

    DEFF Research Database (Denmark)

    Foreword B150 –Civil Engineering Futures consists of interviews made, articles written, and projects presented in connection with the 150th anniversary celebrations of the study of civil engineering in Denmark. Instead of a historical retrospect, it was decided to look into the future. What......, has helped create a new standard for sustainable building. One day of the master class was devoted to lectures by civil engineers and architects from Denmark and abroad who talked about their own experience with Integrated Design. The anniversary event was rounded off with another important topic...

  19. Thermo-transferred thermoluminescence (TTTl) in potassium-yttrium double fluoride doped with terbium

    Energy Technology Data Exchange (ETDEWEB)

    Gallegos, A.; Rivera, T.; Diaz G, J. A. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Legaria 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico); Azorin, J. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, San Rafael Atlixco No. 186, Col. Vicentina, 09340 Mexico D. F. (Mexico); Azorin, J. C. [Universidad de Guanajuato, Division de Ciencias e Ingenierias-Campus Leon, Lomas del Bosque No. 103, Col. Lomas del Campestre, 37000 Leon, Guanajuato (Mexico); Licona, R.; Rivas, F.; Hernandez C, G. [Benemerita Universidad Autonoma de Puebla, Facultad de Ciencias Quimicas, 14 Sur y San Claudio, Ciudad Universitaria, Puebla de Zaragoza, Puebla (Mexico); Khaidukov, N. [Institute of General and Inorganic Chemistry, Lenin SK 11 Prospect 31, Moscow 117907 (Russian Federation)

    2011-02-15

    This paper presents results of studying the thermo-transferred thermoluminescence (TTTl) phenomenon in potassium-yttrium double fluoride doped with terbium (K{sub 2}YF{sub 5:}Tb) at different impurity concentrations (0.8%, 0.95% and 0.99%). Previously to study the TTTl phenomenon, structural characterization and chemical composition of the materials were determined. The structural studies were conducted using a scanning electron microscope; meanwhile, chemical composition was analyzed using energy dispersive X-ray spectroscopy. Thermoluminescence kinetics was studied irradiating the samples with {sup 137}Cs gamma rays as well as with {sup 90}Sr/{sup 90}Y beta rays, analyzing the glow curves by the deconvolution method for obtaining the kinetic parameters. (Author)

  20. The influence of pressure on the photoluminescence properties of a terbium-adipate framework

    Science.gov (United States)

    Spencer, Elinor C.; Zhao, Jing; Ross, Nancy L.; Andrews, Michael B.; Surbella, Robert G.; Cahill, Christopher L.

    2013-06-01

    The influence of pressure (over the 0-4.7 GPa range) on the photoluminescence emissions and crystal structure of the known 3D terbium-adipate metal-organic framework material Tb-GWMOF6 has been evaluated by high-pressure single-crystal X-ray diffraction and spectroscopic techniques. The results from this study show that this complex lanthanide framework structure undergoes three phase transitions within the 0-4 GPa pressure range that involve alterations in the number of symmetry independent Tb3+ ion sites within the crystal lattice. These pressure induced modifications to the structure of Tb-GWMOF6 lead to pronounced changes in the profiles of the 5D4→7F5 emission spectra of this complex.

  1. Terbium Radionuclides for Theranostics Applications: A Focus On MEDICIS-PROMED

    Science.gov (United States)

    Cavaier, R. Formento; Haddad, F.; Sounalet, T.; Stora, T.; Zahi, I.

    A new facility, named CERN-MEDICIS, is under construction at CERN to produce radionuclides for medical applications. In parallel, the MEDICIS-PROMED, a Marie Sklodowska-Curie innovative training network of the Horizon 2020 European Commission's program, is being coordinated by CERN to train young scientists on the production and use of innovative radionuclides and develop a network of experts within Europe. One program within MEDICIS-PROMED is to determine the feasibility of producing innovative radioisotopes for theranostics using a commercial middle-sized high-current cyclotron and the mass separation technology developed at CERN-MEDICIS. This will allow the production of high specific activity radioisotopes not achievable with the common post-processing by chemical separation. Radioisotopes of scandium, copper, arsenic and terbium have been identified. Preliminary studies of activation yield and irradiation parameters optimization for the production of Tb-149 will be described.

  2. Dielectric and conducting behavior of gadolinium-terbium fumarate heptahydrate crystals

    Science.gov (United States)

    Shah, M. D.; Want, B.

    2015-07-01

    Gadolinium-terbium fumarate heptahydrate crystals were grown in silica gel by using single gel diffusion technique. The crystals were characterized by different physico-chemical techniques of characterization. Powder X-ray diffraction results showed that the grown material is purely crystalline in nature. Elemental analyses suggested the chemical formula of the compound to be Gd Tb (C4H2O4)3ṡ7H2O. Energy dispersive X-ray analysis confirmed the presence of Gd and Tb in the title compound. The dielectric and conductivity studies of the grown compound were carried as function of frequency of applied field and the temperature. The grown material showed a dielectric anomaly which was correlated with its thermal behavior. The ac conductivity of the material showed Jonscher's power law behavior: σ(ω)=σo+Aωs, with a temperature-dependent power exponent s(<1). The conductivity was found to be a function of temperature and frequency.

  3. Highly sensitive detection of dipicolinic acid with a water-dispersible terbium-metal organic framework.

    Science.gov (United States)

    Bhardwaj, Neha; Bhardwaj, Sanjeev; Mehta, Jyotsana; Kim, Ki-Hyun; Deep, Akash

    2016-12-15

    The sensitive detection of dipicolinic acid (DPA) is strongly associated with the sensing of bacterial organisms in food and many types of environmental samples. To date, the demand for a sensitive detection method for bacterial toxicity has increased remarkably. Herein, we investigated the DPA detection potential of a water-dispersible terbium-metal organic framework (Tb-MOF) based on the fluorescence quenching mechanism. The Tb-MOF showed a highly sensitive ability to detect DPA at a limit of detection of 0.04nM (linear range of detection: 1nM to 5µM) and also offered enhanced selectivity from other commonly associated organic molecules. The present study provides a basis for the application of Tb-MOF for direct, convenient, highly sensitive, and specific detection of DPA in the actual samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. A New Bis(phthalocyaninato) Terbium Single-Ion Magnet with an Overall Excellent Magnetic Performance.

    Science.gov (United States)

    Chen, Yuxiang; Ma, Fang; Chen, Xiaoxiang; Dong, Bowei; Wang, Kang; Jiang, Shangda; Wang, Chiming; Chen, Xin; Qi, Dongdong; Sun, Haoling; Wang, Bingwu; Gao, Song; Jiang, Jianzhuang

    2017-11-20

    Bulky and strong electron-donating dibutylamino groups were incorporated onto the peripheral positions of one of the two phthalocyanine ligands in the bis(phthalocyaninato) terbium complex, resulting in the isolation of heteroleptic double-decker (Pc)Tb{Pc[N(C4H9)2]8} {Pc = phthalocyaninate; Pc[N(C4H9)2]8 = 2,3,9,10,16,17,23,24-octakis(dibutylamino)phthalocyaninate} with the nature of an unsymmetrical molecular structure, a square-antiprismatic coordination geometry, an intensified coordination field strength, and the presence of organic radical-f interaction. As a total result of all these factors, this sandwich-type tetrapyrrole lanthanide single-ion magnet (SIM) exhibits an overall enhanced magnetic performance including a high blocking temperature (TB) of 30 K and large effective spin-reversal energy barrier of Ueff = 939 K, rendering it the best sandwich-type tetrapyrrole lanthanide SIM reported thus far.

  5. Ultralarge magneto-optic rotations and rotary dispersion in terbium gallium garnet single crystal.

    Science.gov (United States)

    Shaheen, Amrozia; Majeed, Hassaan; Anwar, Muhammad Sabieh

    2015-06-10

    We report systematically acquired data on the Verdet constant of terbium gallium garnet for wavelengths ranging from visible to near-infrared (405-830 nm) regime. Our experimental method of Stokes polarimetry is based on the Fourier decomposition of the received light intensity and allows unambiguous determination of both the Faraday rotation and the ellipticity of the emergent light. Temperature-dependent investigations in the range of 8-300 K extend earlier reports and verify the Verdet's constant direct dependence on the magnetization, whose first-order approximation is simply a manifestation of the Curie's law. Further, a least-squares fitting of the experimental data correlates well with theoretical predictions. At a wavelength of 405 nm and temperature of 8 K, the rotation is approximately 500°.

  6. Terbium fluorescence as a sensitive, inexpensive probe for UV-induced damage in nucleic acids

    Energy Technology Data Exchange (ETDEWEB)

    El-Yazbi, Amira F.; Loppnow, Glen R., E-mail: glen.loppnow@ualberta.ca

    2013-07-05

    Graphical abstract: -- Highlights: •Simple, inexpensive, mix-and-read assay for positive detection of DNA damage. •Recognition of undamaged DNA via hybridization to a hairpin probe. •Terbium(III) fluorescence reports the amount of damage by binding to ssDNA. •Tb/hairpin is a highly selective and sensitive fluorescent probe for DNA damage. -- Abstract: Much effort has been focused on developing methods for detecting damaged nucleic acids. However, almost all of the proposed methods consist of multi-step procedures, are limited, require expensive instruments, or suffer from a high level of interferences. In this paper, we present a novel simple, inexpensive, mix-and-read assay that is generally applicable to nucleic acid damage and uses the enhanced luminescence due to energy transfer from nucleic acids to terbium(III) (Tb{sup 3+}). Single-stranded oligonucleotides greatly enhance the Tb{sup 3+} emission, but duplex DNA does not. With the use of a DNA hairpin probe complementary to the oligonucleotide of interest, the Tb{sup 3+}/hairpin probe is applied to detect ultraviolet (UV)-induced DNA damage. The hairpin probe hybridizes only with the undamaged DNA. However, the damaged DNA remains single-stranded and enhances the intrinsic fluorescence of Tb{sup 3+}, producing a detectable signal directly proportional to the amount of DNA damage. This allows the Tb{sup 3+}/hairpin probe to be used for sensitive quantification of UV-induced DNA damage. The Tb{sup 3+}/hairpin probe showed superior selectivity to DNA damage compared to conventional molecular beacons probes (MBs) and its sensitivity is more than 2.5 times higher than MBs with a limit of detection of 4.36 ± 1.2 nM. In addition, this probe is easier to synthesize and more than eight times cheaper than MBs, which makes its use recommended for high-throughput, quantitative analysis of DNA damage.

  7. Fine- and hyperfine structure investigations of even configuration system of atomic terbium

    Science.gov (United States)

    Stefanska, D.; Elantkowska, M.; Ruczkowski, J.; Furmann, B.

    2017-03-01

    In this work a parametric study of the fine structure (fs) and the hyperfine structure (hfs) for the even-parity configurations of atomic terbium (Tb I) is presented, based in considerable part on the new experimental results. Measurements on 134 spectral lines were performed by laser induced fluorescence (LIF) in a hollow cathode discharge lamp; on this basis, the hyperfine structure constants A and B were determined for 52 even-parity levels belonging to the configurations 4f85d6s2, 4f85d26s or 4f96s6p; in all the cases those levels were involved in the transitions investigated as the lower levels. For 40 levels the hfs was examined for the first time, and for the remaining 12 levels the new measurements supplement our earlier results. As a by-product, also preliminary values of the hfs constants for 84 odd-parity levels were determined (the investigations of the odd-parity levels system in the terbium atom are still in progress). This huge amount of new experimental data, supplemented by our earlier published results, were considered for the fine and hyperfine structure analysis. A multi-configuration fit of 7 configurations was performed, taking into account second-order of perturbation theory, including the effects of closed shell-open shell excitations. Predicted values of the level energies, as well as of magnetic dipole and electric quadrupole hyperfine structure constants A and B, are quoted in cases when no experimental values are available. By combining our experimental data with our own semi-empirical procedure it was possible to identify correctly the lower and upper level of the line 544.1440 nm measured by Childs with the use of the atomic-beam laser-rf double-resonance technique (Childs, J Opt Soc Am B 9;1992:191-6).

  8. Structural and optical characterization of terbium doped ZnGa2O4 thin films deposited by RF magnetron sputtering

    Science.gov (United States)

    Somasundaram, K.; Girija, K. G.; Sudarsan, V.; Selvin, P. Christopher; Vatsa, R. K.

    2016-05-01

    Tb3+ doped ZnGa2O4 nanophosphor (21 nm) has been synthesized via low temperature polyol route and subsequently thin films of the same were deposited on glass and ITO substrates by RF magnetron sputtering. The films were characterized by X-ray Diffraction and luminescence measurements. The XRD pattern showed that Tb3+ doped ZnGa2O4 nanophosphor has a cubic spinel phase. Luminescence behavior of the nanophosphor and as deposited sputtered film was investigated. The PL emission spectra of nanophosphor gave a broad ZnGa2O4 host emission band along with a strong terbium emission and the thin films showed only broad host emission band and there was no terbium ion emission.

  9. Determination of fluoxetine in pharmaceutical and biological samples based on the silver nanoparticle enhanced fluorescence of fluoxetine-terbium complex.

    Science.gov (United States)

    Lotfi, Ali; Manzoori, Jamshid L

    2016-11-01

    In this study, a simple and sensitive spectrofluorimetric method is presented for the determination of fluoxetine based on the enhancing effect of silver nanoparticles (AgNPs) on the terbium-fluoxetine fluorescence emission. The AgNPs were prepared by a simple reduction method and characterized by UV-Vis spectroscopy and transmission electron microscopy. It was indicated that these AgNPs have a remarkable amplifying effect on the terbium-sensitized fluorescence of fluoxetine. The effects of various parameters such as AgNP and Tb(3+) concentration and the pH of the media were investigated. Under obtained optimal conditions, the fluorescence intensity of the terbium-fluoxetine-AgNP system was enhanced linearly by increasing the concentration of fluoxetine in the range of 0.008 to 19 mg/L. The limit of detection (b + 3s) was 8.3 × 10(-4) mg/L. The interference effects of common species found in real samples were also studied. The method had good linearity, recovery, reproducibility and sensitivity, and was satisfactorily applied for the determination of fluoxetine in tablet formulations, human urine and plasma samples. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  10. Neutron Diffraction and Electrical Transport Studies on Magnetic Transition in Terbium at High Pressures and Low Temperatures

    Science.gov (United States)

    Thomas, Sarah; Montgomery, Jeffrey; Tsoi, Georgiy; Vohra, Yogesh; Weir, Samuel; Tulk, Christopher; Moreira Dos Santos, Antonio

    2013-06-01

    Neutron diffraction and electrical transport measurements have been carried out on the heavy rare earth metal terbium at high pressures and low temperatures in order to elucidate its transition from a helical antiferromagnetic to a ferromagnetic ordered phase as a function of pressure. The electrical resistance measurements using designer diamonds show a change in slope as the temperature is lowered through the ferromagnetic Curie temperature. The temperature of the ferromagnetic transition decreases at a rate of -16.7 K/GPa till 3.6 GPa, where terbium undergoes a structural transition from hexagonal close packed (hcp) to an α-Sm phase. Above this pressure, the electrical resistance measurements no longer exhibit a change in slope. In order to confirm the change in magnetic phase suggested by the electrical resistance measurements, neutron diffraction measurements were conducted at the SNAP beamline at the Oak Ridge National Laboratory. Measurements were made at pressures to 5.3 GPa and temperatures as low as 90 K. An abrupt increase in peak intensity in the neutron diffraction spectra signaled the onset of magnetic order below the Curie temperature. A magnetic phase diagram of rare earth metal terbium will be presented to 5.3 GPa and 90 K based on these studies.

  11. 37 CFR 150.4 - Evaluation.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Evaluation. 150.4 Section 150...(a)(2) § 150.4 Evaluation. (a) Upon submission of a request by a foreign government for the issuance... Director to initiate independently an evaluation pursuant to § 150.2(a) of this part, a notice will be...

  12. Study of Silver Nanoparticles Sensitized Fluorescence and Second-Order Scattering of Terbium(III-Pefloxacin Mesylate Complex and Determination of Pefloxacin Mesylate

    Directory of Open Access Journals (Sweden)

    Aiyun Li

    2014-01-01

    Full Text Available α-Keto acid of pefloxacin mesylate (PFLX can form the complex with Terbium(III. The intramolecular energy from PFLX to Terbium(III ion takes place when excited, and thus Terbium(III excited state is formed and then emits the characteristic fluorescence of Terbium(III, locating at 490, 545, 580, and 620 nm. The second-order scattering (SOS peak at 545 nm also appears for the complex with the exciting wavelength of 273 nm. When the silver nanoparticles are added to the system, the luminescence intensity at 545 nm greatly increased. So, with the adding of nanoparticles to the Terbium(III-PFLX complex, not only is the intramolecular energy promoted but also the SOS intensity is enhanced. The experimental results show that it is the silver nanoparticles with certain size and certain concentration which can greatly enhance the fluorescence-SOS intensity, and the relative intensity at 545 nm is proportional to the amount of PFLX. Based on this phenomenon, a novel method for the determination of PFLX has been developed and applied to the determination of PFLX in capsule and serum samples.

  13. Influence of crystalline structure on the luminescence properties of terbium orthotantalates

    Energy Technology Data Exchange (ETDEWEB)

    Siqueira, Kisla P.F. [Departamento de Química, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, ICEB II, Ouro Preto 35400-000, Minas Gerais (Brazil); Carmo, Alexandre P. [Instituto Federal Fluminense, Campus Cabo Frio, RJ 28909-971 (Brazil); Bell, Maria J.V. [Departamento de Física, Universidade Federal de Juiz de Fora, Juiz de Fora 36036-330, MG (Brazil); Dias, Anderson, E-mail: anderson_dias@iceb.ufop.br [Departamento de Química, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, ICEB II, Ouro Preto 35400-000, Minas Gerais (Brazil)

    2013-06-15

    Terbium orthotantalate powders were produced with M-fergusonite type (I2/a) and M′-fergusonite type (P2/a) structures. The samples were studied by X-ray diffraction, Raman scattering, and photoluminescence measurements (emission and decay curves). The results showed that crystalline materials were obtained with all the 18 Raman-active modes predicted by group theory calculations. Also, it was observed through photoluminescence decay curves that the Tb{sup 3+} ions occupies only one-symmetry site in both crystallographic arrangements. Photoluminescence emission curves exhibited some variation in spectral shape, peak position, and relative intensity as a consequence of their different crystalline arrangements. The dominated emission of Tb{sup 3+} ({sup 5}D{sub 4}→{sup 7}F{sub 5}) is centered with a maximum intensity at 549.2 nm (M-type) and 543.0 nm (M′-type). Fluorescence lifetimes for M-TbTaO{sub 4} and M′-TbTaO{sub 4} were determined as 33.4 μs and 1.25 ms, respectively. M′-type materials seems to be the most suitable for luminescent devices and could be a potential green luminescent material due to the strongest emission if compared with the M-fergusonite type. -- Highlights: ► Terbium orthotantalates were prepared in two different crystalline structures: I2/a and P2/a. ► XRD and Raman scattering showed that the different space groups obtained were exhibited all the 18 Raman-active modes. ► PL decay curves that the Tb{sup 3+} ions occupies only one-symmetry site in both crystallographic arrangements. ► Dominated emission of Tb{sup 3+} ({sup 5}D{sub 4}→{sup 7}F{sub 5}) is centered with a maximum intensity at 549 nm (M-type) and 543 nm (M′-type). ► Fluorescence lifetimes for M-TbTaO{sub 4} and M′-TbTaO{sub 4} were determined as 33.4 μs and 1.25 ms, respectively.

  14. B 150 civil engineering futures

    DEFF Research Database (Denmark)

    challenges will the next 150 years bring civil engineers? Researchers and lecturers at DTU’s Department of Civil Engineering (known as DTU Byg) suggested possible events, and we also consulted civil engineers and their business partners in the building industry. In this way, a programme was put together......, has helped create a new standard for sustainable building. One day of the master class was devoted to lectures by civil engineers and architects from Denmark and abroad who talked about their own experience with Integrated Design. The anniversary event was rounded off with another important topic...... Anniversary Conference on 16 November offered a number of seminars organised by the professional associations and lectures by civil engineers Stephen Selkowich and Cecil Balmond. In collaboration with the architect Renzo Piano, Stephen Selkowich has developed and tested low-energy façade systems; and Cecil...

  15. 150 Bulgarian students visit CERN

    CERN Multimedia

    Alizée Dauvergne

    2010-01-01

    Between 27 March and 8 April 2010, 150 Bulgarian students from the Astronomical Observatory in Varna visited CERN as part of the “From Galileo to CERN” programme. Bulgarian students participating in the "From Galileo to CERN" educational programme. “It’s interesting to combine astronomy and particle physics”, explains Svejina Dimitrova, organiser of the programme and Director of Varna Astronomical Observatory. The three groups, each one comprising 50 students, first visited Pisa, Padua and other places in Italy  related to Galileo’s life. “Thanks to the visit, students understood telescopes and why Galileo is such an important scientist”, says Svejina. After Italy, they came to CERN for three days and visited several sites: Linac, the Computer Centre CCC, etc. Another group of Bulgarian students in their visit to CERN. “They became aware that particle physics is not only the...

  16. B 150 civil engineering futures

    DEFF Research Database (Denmark)

    challenges will the next 150 years bring civil engineers? Researchers and lecturers at DTU’s Department of Civil Engineering (known as DTU Byg) suggested possible events, and we also consulted civil engineers and their business partners in the building industry. In this way, a programme was put together...... a previously passive insulation material is altered to play an active role in a building. The Design Master Class was for architects, civil engineers and students. It was led by Richard Horden, who is not only the head of a design department at Munich Technical University, but also works on design in his own...... to develop a technically advanced form of aesthetics. The Master Class in low energy buildings was led by civil engineer, Svend Svendsen, a Professor at DTU Byg. Together with colleagues and students, he has achieved an extensive knowledge of Integrated Design. In fact, the situation is that our knowledge...

  17. Laser control and temperature switching of luminescence intensity in photostable transparent film based on terbium(III) β-diketonate complex

    Science.gov (United States)

    Lapaev, Dmitry V.; Nikiforov, Victor G.; Safiullin, Georgy M.; Lobkov, Vladimir S.; Salikhov, Kev M.; Knyazev, Andrey A.; Galyametdinov, Yury G.

    2014-11-01

    The study of the terbium(III) and gadolinium(III) β-diketonate complexes by photoluminescence spectroscopy reveals considerable changes of the photophysical properties of the complexes under the UV laser irradiation. The measurements show the enhancement of the luminescence intensities in the vitrified transparent film of the terbium(III) complex as well as the gadolinium(III) complex under the 337 nm laser irradiation at room temperature. The irradiated film of the terbium(III) complex restores the initial photophysical properties after heating close to the melting temperature (∼353 K) and cooling. We observe no change of the luminescent properties of the irradiated film for months. These features can be used for the design of new lanthanide-based photostable systems with laser control of the luminescence intensity.

  18. Development of functionalized terbium fluorescent nanoparticles for antibody labeling and time-resolved fluoroimmunoassay application.

    Science.gov (United States)

    Ye, Zhiqiang; Tan, Mingqian; Wang, Guilan; Yuan, Jingli

    2005-01-15

    Silica-based functionalized terbium fluorescent nanoparticles were prepared, characterized and developed as a fluorescence probe for antibody labeling and time-resolved fluoroimmunoassay. The nanoparticles were prepared in a water-in-oil (W/O) microemulsion containing a strongly fluorescent Tb(3+) chelate, N,N,N(1),N(1)-[2,6-bis(3'-aminomethyl-1'-pyrazolyl)phenylpyridine] tetrakis(acetate)-Tb(3+) (BPTA-Tb(3+)), Triton X-100, octanol, and cyclohexane by controlling copolymerization of tetraethyl orthosilicate (TEOS) and 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethoxysilane (AEPS) with ammonia water. The characterizations by transmission electron microscopy and fluorometric methods show that the nanoparticles are spherical and uniform in size, 45 +/- 3nm in diameter, strongly fluorescent with fluorescence quantum yield of 10% and a long fluorescence lifetime of 2.0ms. The amino groups directly introduced to the nanoparticle's surface by using AEPS in the preparation made the surface modification and bioconjugation of the nanoparticles easier. The nanoparticle-labeled anti-human alpha-fetoprotein antibody was prepared and used for time-resolved fluoroimmunoassay of alpha-fetoprotein (AFP) in human serum samples. The assay response is linear from 0.10ngml(-1) to about 100ngml(-1) with the detection limit of 0.10ngml(-1). The coefficient variations (CVs) of the method are less than 9.0%, and the recoveries are in the range of 84-98% for human serum sample measurements.

  19. Highly efficient precipitation of phosphoproteins using trivalent europium, terbium, and erbium ions

    Energy Technology Data Exchange (ETDEWEB)

    Guezel, Yueksel; Rainer, Matthias; Mirza, Munazza Raza; Bonn, Guenther K. [Leopold-Franzens University, Institute of Analytical Chemistry and Radiochemistry, Innsbruck (Austria)

    2012-05-15

    This study describes a highly efficient method for the selective precipitation of phosphoproteins by trivalent europium, terbium, and erbium metal ions. These metal cations belong to the group of lanthanides and are known to be hard acceptors with an overwhelming preference for oxygen-containing anions such as phosphates to which they form very tight ionic bonds. The method could be successfully applied to specifically precipitate phosphoproteins from complex samples including milk and egg white by forming solid metal-protein complexes. Owing to the low solubility product of the investigated lanthanide salts, the produced metal-protein complexes showed high stability. The protein pellets were extensively washed to remove nonphosphorylated proteins and contaminants. For the analysis of proteins the pellets were first dissolved in 30 % formic acid and subjected to matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) MS. For peptide mass-fingerprint analysis the precipitated phosphoproteins were enzymatically digested using microwave-assisted digestion. The method was found to be highly specific for the isolation and purification of phosphoproteins. Protein quantification was performed by colorimetric detection of total precipitated phosphoproteins and revealed more than 95 % protein recovery for each lanthanide salt. (orig.)

  20. A Terbium Sensitized Luminescence Method for the Assay of Flubiprofen in Pharmaceutical Formulations

    Directory of Open Access Journals (Sweden)

    Salma M.Z. Al-Kindy

    2014-12-01

    Full Text Available A sensitive time-resolved luminescence method for the determination of flubiprofen (FLP in methanol and in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb3+ by the formation of a ternary complex with FLP in the presence of 4,7 diphenyl 1,10 phenanthroline (DPP as co-ligand, and Tween-20 as surfactant. The signal for Tb-FLP-DPP was monitored at λex  = 285 nm and λem  = 552 nm. Optimum conditions for the formation of the complex in an aqueous system were TRIS buffer, pH 8.0, DPP (2.5Å~10−7  M, Tween-20 (0.30% and 4Å~10-5  mol L-1  of Tb3+  which allowed the determination of 20–1000 ng mL-1  of FLP with a limit of detection (LOD of 10 ng mL-1 . The relative standard deviations of the method ranged between 0.6 and 1.4% indicating excellent reproducibility of the method. The proposed method was successfully applied for the assays of FLP in pharmaceutical formulations and spiked tap water samples with average recoveries of 87% – 95%.

  1. Sensitization effects of supramolecular assemblies on the luminescence of terbium-ion prulifloxacin complexes

    Energy Technology Data Exchange (ETDEWEB)

    Wang Hong; Yi Chongyue; Li Xue; Fang Fang [School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Yang Yajiang, E-mail: yjyang@mail.hust.edu.c [School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2011-04-15

    Luminescence enhancement of terbium-ion prulifloxacin complexes (Tb(III)-PUFX) in supramolecular hydrogels formed by assembly of 1,3:2,4-di-O-benzylidene-D-sorbitol (DBS) was investigated by steady-state fluorescence, varying temperature fluorescence and time-resolved fluorescence. The luminescence images show that Tb(III)-PUFX were dispersed in the DBS gels. The luminescence intensity of Tb(III)-PUFX in the DBS gels was significantly increased in comparison with that in corresponding aqueous solutions. The varying temperature fluorescent spectra show that the luminescence intensity of Tb(III)-PUFX decreased with an increase in the temperature. This implies that the luminescence enhancement of Tb(III)-PUFX is related to the dissociation and the formation of the DBS assemblies. Time-resolved fluorescence measurements show slower rotational motion in DBS gels in comparison with that in the corresponding aqueous solutions. This may be ascribed to a unique microstructure of three-dimensional network formed by DBC aggregates, resulting in deactivation of the nonradiative relaxation. The images of field emission scanning electron microscopy and polarized optical microscopy indicate that the morphology of the DBS assemblies was not influenced upon addition of Tb(III)-PUFX to the DBS gels.

  2. A Nanoscale Multiresponsive Luminescent Sensor Based on a Terbium(III) Metal-Organic Framework.

    Science.gov (United States)

    Dang, Song; Wang, Ting; Yi, Feiyan; Liu, Qinghui; Yang, Weiting; Sun, Zhong-Ming

    2015-08-01

    A nanoscale terbium-containing metal-organic framework (nTbL), with a layer-like structure and [H2 NMe2 ](+) cations located in the framework channels, was synthesized under hydrothermal conditions. The structure of the as-prepared sample was systematically confirmed by powder XRD and elemental analysis; the morphology was characterized by field-emission SEM and TEM. The photoluminescence studies revealed that rod-like nTbL exhibited bright-green emission, corresponding to (5)D4 →(7)FJ (J=6-3) transitions of the Tb(3+) ion under excitation. Further sensing measurements revealed that as-prepared nTbL could be utilized as a multiresponsive luminescent sensor, which showed significant and exclusive detection ability for Fe(3+) ions and phenylmethanol. These results highlight the practical applications of lanthanide-containing metal-organic frameworks as fluorescent probes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Terbium-Doped VO2 Thin Films: Reduced Phase Transition Temperature and Largely Enhanced Luminous Transmittance.

    Science.gov (United States)

    Wang, Ning; Duchamp, Martial; Dunin-Borkowski, Rafal E; Liu, Shiyu; Zeng, XianTing; Cao, Xun; Long, Yi

    2016-01-26

    Vanadium dioxide (VO2) is a well-known thermochromic material with large IR modulating ability, promising for energy-saving smart windows. The main drawbacks of VO2 are its high phase transition temperature (τ(c) = 68°C), low luminous transmission (T(lum)), and weak solar modulating ability (ΔT(sol)). In this paper, the terbium cation (Tb(3+)) doping was first reported to reduce τ(c) and increase T(lum) of VO2 thin films. Compared with pristine VO2, 2 at. % doping level gives both enhanced T(lum) and ΔT(sol) from 45.8% to 54.0% and 7.7% to 8.3%, respectively. The T(lum) increases with continuous Tb(3+) doping and reaches 79.4% at 6 at. % doping level, representing ∼73.4% relative increment compared with pure VO2. This has surpassed the best reported doped VO2 thin films. The enhanced thermochromic properties is meaningful for smart window applications of VO2 materials.

  4. Luminescent investigations of terbium(III) biosorption as a surrogate for heavy metals and radionuclides.

    Science.gov (United States)

    Achyuthan, Komandoor E; Arango, Dulce C; Carles, Elizabeth L; Cutler, Christopher E; Meyer, Lauren A; Brozik, Susan M

    2009-07-01

    We describe a metal transport system for investigating the interfacial interactions between the anionic surface charge of a gram-negative bacterium (Escherichia coli) and a trivalent cationic metal, Tb3+. We believe this is the first description of the uptake kinetics, sub- and intracellular distribution, and temporal fate of Tb3+ ion in E. coli. We used the luminescence of the terbium-dipicolinic acid chelate to study metal ion transport. The bacteria had a high tolerance for the metal (IC(50) = 4 mM Tb3+). Metal ion transport was passive and metabolism independent. The uptake kinetics rapidly reached a maximum within 15 min, followed by a stasis for 60 min, and declining thereafter between 120 and 240 min, resulting in a biphasic curve. During this period, greater than one-third of the metal ion was sequestered within the cell. Our choice of a safe Biosafety Level I E. coli bacteria and the relatively non-toxic Tb3+ metal represents a model system for luminescent investigations of biosorption, for studying bacterial-water interfacial chemistry and for the bioremediation of heavy metals and radionuclides.

  5. 45 CFR 150.415 - Intervention.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Intervention. 150.415 Section 150.415 Public... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.415 Intervention. (a) The... intervention will not unduly delay or prejudice the adjudication of the rights of the existing parties. (b) A...

  6. 32 CFR 935.150 - Registration.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Registration. 935.150 Section 935.150 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE TERRITORIAL AND INSULAR REGULATIONS WAKE ISLAND CODE Registration and Island Permits § 935.150 Registration. (a) Each person who has...

  7. 21 CFR 820.150 - Storage.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Storage. 820.150 Section 820.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES QUALITY SYSTEM REGULATION Handling, Storage, Distribution, and Installation § 820.150 Storage. (a) Each...

  8. 21 CFR 812.150 - Reports.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Reports. 812.150 Section 812.150 Food and Drugs... INVESTIGATIONAL DEVICE EXEMPTIONS Records and Reports § 812.150 Reports. (a) Investigator reports. An investigator shall prepare and submit the following complete, accurate, and timely reports: (1) Unanticipated adverse...

  9. 21 CFR 131.150 - Heavy cream.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Heavy cream. 131.150 Section 131.150 Food and... CONSUMPTION MILK AND CREAM Requirements for Specific Standardized Milk and Cream § 131.150 Heavy cream. (a) Description. Heavy cream is cream which contains not less than 36 percent milkfat. It is pasteurized or ultra...

  10. 7 CFR 917.150 - Lot stamping.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Lot stamping. 917.150 Section 917.150 Agriculture... CALIFORNIA Rules and Regulations Regulation of Daily Shipments § 917.150 Lot stamping. Except when loaded..., prior to shipment, with a Federal-State Inspection Service lot stamp number, assigned by such Service...

  11. 21 CFR 164.150 - Peanut butter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Peanut butter. 164.150 Section 164.150 Food and... § 164.150 Peanut butter. (a) Peanut butter is the food prepared by grinding one of the shelled and... preservatives, and color additives are not suitable ingredients in peanut butter. Oil products used as optional...

  12. 21 CFR 150.110 - Fruit butter.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Fruit butter. 150.110 Section 150.110 Food and... CONSUMPTION FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products § 150.110 Fruit butter. (a) The fruit butters...

  13. Construction of the energy matrix for complex atoms. Part VIII: Hyperfine structure HPC calculations for terbium atom

    Science.gov (United States)

    Elantkowska, Magdalena; Ruczkowski, Jarosław; Sikorski, Andrzej; Dembczyński, Jerzy

    2017-11-01

    A parametric analysis of the hyperfine structure (hfs) for the even parity configurations of atomic terbium (Tb I) is presented in this work. We introduce the complete set of 4fN-core states in our high-performance computing (HPC) calculations. For calculations of the huge hyperfine structure matrix, requiring approximately 5000 hours when run on a single CPU, we propose the methods utilizing a personal computer cluster or, alternatively a cluster of Microsoft Azure virtual machines (VM). These methods give a factor 12 performance boost, enabling the calculations to complete in an acceptable time.

  14. Spectrofluorimetric determination of human serum albumin using terbium-danofloxacin probe.

    Science.gov (United States)

    Ramezani, Amir M; Manzoori, Jamshid L; Amjadi, Mohammad; Jouyban, Abolghasem

    2012-01-01

    A spectrofluorimetric method is proposed for the determination of human serum albumin (HSA) and bovine serum albumin (BSA) using terbium-danofloxacin (Tb(3+)-Dano) as a fluorescent probe. These proteins remarkably enhance the fluorescence intensity of the Tb(3+)-Dano complex at 545 nm, and the enhanced fluorescence intensity of Tb(3+)-Dano is proportional to the concentration of proteins (HSA and BSA). Optimum conditions for the determination of HSA were investigated and found that the maximum response was observed at: pH = 7.8, [Tb(3+)] = 8.5 × 10(-5) mol L(-1), [Dano] = 1.5 × 10(-4) mol L(-1). The calibration graphs for standard solutions of BSA, HSA, and plasma samples of HSA were linear in the range of 0.2 × 10(-6) - 1.3 × 10(-6) mol L(-1), 0.2 × 10(-6) - 1.4 × 10(-6) mol L(-1), and 0.2 × 10(-6) - 1 × 10(-6) mol L(-1), respectively. The detection limits (S/N = 3) for BSA, HSA, and plasma sample of HSA were 8.7 × 10(-8) mol L(-1), 6.2 × 10(-8) mol L(-1), and 8.1 × 10(-8) mol L(-1), respectively. The applicability of the method was checked using a number of real biological plasma samples and was compared with the UV spectrometric reference method. The results was showed that the method could be regarded as a simple, practical, and sensitive alternative method for determination of albumin in biological samples.

  15. Spectrofluorimetric Determination of Human Serum Albumin Using Terbium-Danofloxacin Probe

    Directory of Open Access Journals (Sweden)

    Amir M. Ramezani

    2012-01-01

    Full Text Available A spectrofluorimetric method is proposed for the determination of human serum albumin (HSA and bovine serum albumin (BSA using terbium-danofloxacin (Tb3+-Dano as a fluorescent probe. These proteins remarkably enhance the fluorescence intensity of the Tb3+-Dano complex at 545 nm, and the enhanced fluorescence intensity of Tb3+-Dano is proportional to the concentration of proteins (HSA and BSA. Optimum conditions for the determination of HSA were investigated and found that the maximum response was observed at: pH=7.8, [Tb3+] =8.5×10−5 mol L−1, [Dano] =1.5×10−4 mol L−1. The calibration graphs for standard solutions of BSA, HSA, and plasma samples of HSA were linear in the range of 0.2×10−6−1.3×10−6 mol L−1, 0.2×10−6−1.4×10−6 mol L−1, and 0.2×10−6−1×10−6 mol L−1, respectively. The detection limits (S/N = 3 for BSA, HSA, and plasma sample of HSA were 8.7×10−8 mol L−1, 6.2×10−8 mol L−1, and 8.1×10−8 mol L−1, respectively. The applicability of the method was checked using a number of real biological plasma samples and was compared with the UV spectrometric reference method. The results was showed that the method could be regarded as a simple, practical, and sensitive alternative method for determination of albumin in biological samples.

  16. Determination of flavonoids in pharmaceutical preparations using Terbium sensitized fluorescence method

    Directory of Open Access Journals (Sweden)

    M Shaghaghi

    2009-12-01

    Full Text Available "nBackground and the Purpose of the Study: The aim of this study was development and validation of a simple, rapid and sensitive spectrofluorimetric method for determination of total flavonoids in two topical formulations of Calendula officinalis, Ziziphus Spina-christi and an oral drop of Hypiran perforatum L. The proposed method is based on the formation of terbium (Tb3+ "n-flavonoids (quercetin as a reference standard complex at pH 7.0, which has fluorescence intensely with maximum emission at 545 nm when excited at 310 nm. "nMethod "n: For ointments masses of topical formulations were weighed and added to ethanol-aqueous buffer (pH 10.0 and the resulting mixtures were shaken and then two phases were separated by centrifugation. Aqueous phases were filtered and then diluted with water. For Hypiran drops an appropriate portion was diluted with ethanol and then aliquots of sample or standard solutions were determined according to the experimental procedure. "nResults "n: Under the optimum conditions, total concentrations of flavonoids (as quercetin equivalent in three tested formulations were found to be 0.204 mg/g (for Dermatin cream, 0.476 mg/g (for Calendula ointment and 13.50 μg/ml (for Hypiran drops. Analytical recoveries from samples spiked with different amounts of quercetin were 96.1-104.0 % with RSD % of less than 3.5. Conclusion : The proposed method which requires a simple dissolution step without any matrix interferences provided high sensitivity and selectivity and was easily applied to determine total flavonoids in real samples of three investigated formulations with excellent reproducibility.

  17. TOF SIMS analysis and generation of white photoluminescence from strontium silicate codoped with europium and terbium

    Energy Technology Data Exchange (ETDEWEB)

    Tshabalala, Modiehi A.; Swart, Hendrik C.; Ntwaeaborwa, Odireleng M., E-mail: ntwaeab@ufs.ac.za [Department of Physics, University of the Free State, P.O Box 339, Bloemfontein 9300 South Africa (South Africa)

    2014-03-15

    White light emitting terbium (Tb{sup 3+}) and europium (Eu{sup 3+}) codoped strontium silicate (Sr{sub 2}SiO{sub 4}) phosphors were prepared by a solid state reaction process. The structure, particle morphology, chemical composition, ion distribution, photoluminescence (PL), and decay characteristics of the phosphors were analyzed by x-ray diffraction (XRD), scanning electron microscopy (SEM), time-of-flight secondary ion mass spectrometry (TOF-SIMS), and PL spectroscopy, respectively. The XRD data showed that our Sr{sub 2}SiO{sub 4} composed of two phases, namely, β-Sr{sub 2}SiO{sub 4} and α′-Sr{sub 2}SiO{sub 4}, and the α′-Sr{sub 2}SiO{sub 4} phase was more prominent than the β-Sr{sub 2}SiO{sub 4} phase. The SEM micrographs showed that the particles were agglomerated together and they did not have definite shapes. All ions (i.e., negative and positive) present in our materials were identified by TOF-SIMS. In addition, the chemical imaging performed with the TOF-SIMS demonstrated how the individual ions including the dopants (Eu{sup 3+} and Tb{sup 3+}) were distributed in the host lattice. White photoluminescence was observed when the Sr{sub 2}SiO{sub 4}:Tb{sup 3+}, Eu{sup 3+} phosphor was excited at 239 nm using a monochromatized xenon lamp as the excitation source. The phosphor exhibited fast decay lifetimes implying that it is not a good candidate for long afterglow applications.

  18. Synthesis, crystal structure and photophysical properties of europium(III) and terbium(III) complexes with pyridine-2,6-dicarboxamide

    NARCIS (Netherlands)

    Tanase, S.; Gallego, P.M.; Gelder, R. de; Fu, W.T.

    2007-01-01

    The reactions of pyridine-2,6-dicarboxamide with europium(III) and terbium(III) triflates led to the formation of mononuclear complexes of formula [Ln(pcam)(3)](CF3SO3)(3) (Ln = Eu 1, Tb 2; pcam stands for pyridine-2,6-dicarboxamide). From single-crystal X-ray diffraction analysis, the complexes

  19. 45 CFR 205.150 - Cost allocation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Cost allocation. 205.150 Section 205.150 Public... ASSISTANCE PROGRAMS § 205.150 Cost allocation. A State plan under title I, IV-A, X, XIV, or XVI (AABD) of the Social Security Act must provide that the State agency will have an approved cost allocation plan on file...

  20. 7 CFR 65.150 - Goat.

    Science.gov (United States)

    2010-01-01

    ..., PORK, LAMB, CHICKEN, GOAT MEAT, PERISHABLE AGRICULTURAL COMMODITIES, MACADAMIA NUTS, PECANS, PEANUTS, AND GINSENG General Provisions Definitions § 65.150 Goat. Goat means meat produced from goats. ...

  1. Zinc sulfide and terbium-doped zinc sulfide films grown by traveling wave reactor atomic layer epitaxy

    CERN Document Server

    Yun, S J; Nam, K S

    1998-01-01

    Zinc sulfide (ZnS) and terbium-doped ZnS (ZnS:Tb) thin films were grown by traveling wave reactor atomic layer epitaxy (ALE). In the present work, ZnCl sub 2 , H sub 2 S, and tris (2,2,6,6-tetramethyl-3,5-heptandionato) terbium (Tb(tmhd) sub 3) were used as the precursors. The dependence of crystallinity and Cl content of ZnS films was investigated on the growth temperature. ZnS and ZnS:Tb films grown at temperatures ranging from 400 to 500 .deg. C showed a hexagonal-2H crystalline structure. The crystallinity of ZnS film was greatly enhanced as the temperature increased. At growth temperatures higher than 450.deg.C, the films showed preferred orientation with mainly (002) diffraction peak. The Cl content decreased from approximately 9 to 1 at.% with the increase in growth temperature from 400 to 500 .deg. C. The segregation of Cl near the surface region and the incorporation of O from Tb(tmhd) sub 3 during ALE process were also observed using Auger electron spectroscopy. The ALE-grown ZnS and ZnS:Tb films re...

  2. Commercializing potassium terbium fluoride, KTF (KTb3F10) faraday crystals for high laser power optical isolator applications

    Science.gov (United States)

    Schlichting, Wolfgang; Stevens, Kevin; Foundos, Greg; Payne, Alexis

    2017-10-01

    Many scientific lasers and increasingly industrial laser systems operate in power regime, require high-performance optical isolators to prevent disruptive light feedback into the laser cavity. The optically active Faraday material is the key optical element inside the isolator. SYNOPTICS has been supplying the laser market with Terbium Gallium Garnet (TGG - Tb3Ga5O12) for many years. It is the most commonly used material for the 650-1100nm range and the key advantages for TGG include its cubic crystal structure for alignment free processing, little to no intrinsic birefringence, and ease of manufacture. However, for high-power laser applications TGG is limited by its absorption at 1064nm and its thermo-optic coefficient, dn/dT. Specifically, thermal lensing and depolarization effects become a limiting factor at high laser powers. While TGG absorption has improved significantly over the past few years, there is an intrinsic limit. Now, SYNOPTICS is commercializing the enhanced new crystal Potassium Terbium Fluoride KTF (KTb3F10) that exhibits much smaller nonlinear refractive index and thermo-optic coefficients, and still exhibits a Verdet constant near that of TGG. This cubic crystal has relatively low absorption and thermo-optic coefficients. It is now fully characterized and available for select production orders. At OPTIFAB in October 2017 we present recent results comparing the performance of KTF to TGG in optical isolators and show SYNOPTICS advances in large volume crystal growth and the production ramp up.

  3. Preparation and photoluminescence enhancement in terbium(III ternary complexes with β-diketone and monodentate auxiliary ligands

    Directory of Open Access Journals (Sweden)

    Devender Singh

    2016-12-01

    Full Text Available A series of new solid ternary complexes of terbium(III ion based on β-diketone ligand acetylacetone (acac and monodentate auxiliary ligands (aqua/urea/triphenylphosphineoxide/pyridine-N-oxide had been prepared. The structural characterizations of synthesized ternary compounds were studied by means of elemental analysis, infrared (IR, and proton nuclear magnetic resonance (NMR spectral techniques. The optical characteristics were investigated with absorption as well as photoluminescence spectroscopy. Thermal behavior of compounds was examined by TGA/DTA analysis and all metal complexes were found to have good thermal stability. The luminescence decay time of complexes were also calculated by monitoring at emission wavelength corresponding to 5D4 → 7F5 transition. A comparative inspection of the luminescent behavior of prepared ternary compounds was performed in order to determine the function of auxiliary ligands in the enhancement of luminescence intensity produced by central terbium(III ion. The color coordinates values suggested that compounds showed bright green emission in visible region in electromagnetic spectrum. Complexes producing green light could play a significant role in the fabrication of efficient light conversion molecular devices for display purposes and lightning systems.

  4. 38 CFR 21.150 - Reader service.

    Science.gov (United States)

    2010-07-01

    ... reader should have an understanding of the subject matter based upon prior training or experience which... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Reader service. 21.150... Special Rehabilitation Services § 21.150 Reader service. (a) Limitations on vision. A veteran considered...

  5. 40 CFR 1065.150 - Continuous sampling.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Continuous sampling. 1065.150 Section... ENGINE-TESTING PROCEDURES Equipment Specifications § 1065.150 Continuous sampling. You may use continuous sampling techniques for measurements that involve raw or dilute sampling. Make sure continuous sampling...

  6. 10 CFR 150.2 - Scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Scope. 150.2 Section 150.2 Energy NUCLEAR REGULATORY... States that have entered into agreements with the Commission or the Atomic Energy Commission pursuant to..., applicant for a license or certificate or quality assurance program approval, holder of a certificate or...

  7. 40 CFR 170.150 - Decontamination.

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    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Decontamination. 170.150 Section 170... PROTECTION STANDARD Standard for Workers § 170.150 Decontamination. (a)(1) Requirement. The agricultural employer must provide decontamination supplies for workers in accordance with this section whenever: (i...

  8. 41 CFR 105-1.150 - Citation.

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    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Citation. 105-1.150... (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.150 Citation. (a) In formal documents, such as legal briefs, citations of chapter 105 material shall include a citation...

  9. 44 CFR 150.3 - Nomination process.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Nomination process. 150.3 Section 150.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Nomination process. (a) The Nominating Officials nominating Firefighters and Civil Defense Officers shall...

  10. 44 CFR 150.7 - Selection process.

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    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Selection process. 150.7 Section 150.7 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... Selection process. (a) President's Award. Nominations for the President's Award shall be reviewed, and...

  11. 21 CFR 133.150 - Hard cheeses.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Hard cheeses. 133.150 Section 133.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... or plant origin capable of aiding in the curing or development of flavor of hard cheese may be added...

  12. 21 CFR 169.150 - Salad dressing.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Salad dressing. 169.150 Section 169.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... purpose of this paragraph, any blend of two or more vinegars is considered to be a vinegar. (2) Lemon...

  13. Synthesis and luminescent study of Ce{sup 3+}-doped terbium-yttrium aluminum garnet

    Energy Technology Data Exchange (ETDEWEB)

    Dotsenko, V.P., E-mail: ssclab@ukr.net [A.V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, Lustdorfskaya doroga 86, 65080 Odessa (Ukraine); Berezovskaya, I.V.; Zubar, E.V.; Efryushina, N.P. [A.V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, Lustdorfskaya doroga 86, 65080 Odessa (Ukraine); Poletaev, N.I.; Doroshenko, Yu.A. [Institute of Combustion and Advanced Technologies, Mechnikov Odessa National University, Dvoryanskaya 2, 65082 Odessa (Ukraine); Stryganyuk, G.B. [Ivan Franko National University of Lviv, Kirilo i Mefodii 8, 79005 Lviv (Ukraine); HASYLAB at DESY, Notkestrasse 85, 22607 Hamburg (Germany); Voloshinovskii, A.S. [Ivan Franko National University of Lviv, Kirilo i Mefodii 8, 79005 Lviv (Ukraine)

    2013-02-15

    Highlights: Black-Right-Pointing-Pointer Ce{sup 3+}-doped garnets (TYAG) were prepared using nanostructured reagents. Black-Right-Pointing-Pointer The Ce{sup 3+} ions cause a very efficient yellow emission of the samples. Black-Right-Pointing-Pointer The reasons for the long wavelength position of this emission are discussed. Black-Right-Pointing-Pointer Contribution from Al atoms to the conduction band of TYAG is quite essential. - Abstract: Terbium-yttrium aluminum garnets (TYAG) doped with Ce{sup 3+} ions have been prepared by solid state reactions between nanostructured oxides of aluminum and rare earths. The luminescent properties of Ce{sup 3+} ions in (Tb{sub 0.8}Y{sub 0.2}){sub 3(1-x)}Ce{sub 3x}Al{sub 5}O{sub 12} (x = 0.03) have been studied upon excitation in the 2-20 eV region. The substitution of Tb{sup 3+} for Y{sup 3+} in the garnet structure results in broadening the emission band and shifting its maximum towards the longer wavelengths. It was found that in addition to the 4f{sup n} {yields} 4f{sup n-1}5d excitation bands of Ce{sup 3+} and Tb{sup 3+} ions, the excitation spectra for the Ce{sup 3+} emission contain broad bands at 6.73 and {approx}9.5 eV. These bands are attributed to the Ce{sup 3+}-bound exciton formation and O 2p {yields} Al 3s, 3p transitions, respectively. In contrast to the predictions based on the results of electronic structure calculations on Y{sub 3}Al{sub 5}O{sub 12} and Tb{sub 4}Al{sub 2}O{sub 9}, the threshold of interband transitions in TYAG is at high energies ( Greater-Than-Or-Slanted-Equal-To 7.3 eV), and contributions from Al{sub tetr} and Al{sub oct} atoms to the conduction-band density of states are evaluated as quite essential.

  14. Structural variations in terbium(III) complexes with 1,3-adamantanedicarboxylate and diverse co-ligands

    Energy Technology Data Exchange (ETDEWEB)

    Thuéry, Pierre, E-mail: pierre.thuery@cea.fr

    2015-07-15

    Terbium nitrate was reacted with 1,3-adamantanedicarboxylic acid (LH{sub 2}) under solvo-hydrothermal conditions with either N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMA) as organic solvents. Hydrolysation of the latter co-solvents resulted in the formation of formate or acetate ions, which are present as co-ligands in the 1D coordination polymer [Tb(L)(HCOO)(H{sub 2}O){sub 2}] (1) and the 2D assembly [Tb(L)(CH{sub 3}COO)(H{sub 2}O)] (2). The increase in dimensionality in the latter arises from the higher connectivity provided by acetate versus formate, the L{sup 2−} ligand being bis-chelating in both cases. The complex [Tb{sub 2}(L){sub 3}(H{sub 2}O){sub 5}][Tb{sub 2}(L){sub 3}(H{sub 2}O){sub 4}]·3H{sub 2}O (3), another 1D species, crystallizes alongside crystals of 2. Further addition of cucurbit[6]uril (CB6), with DMF as co-solvent, gave the two complexes [Tb{sub 2}(L){sub 2}(CB6)(H{sub 2}O){sub 6}](NO{sub 3}){sub 2}·6H{sub 2}O (4) and [H{sub 2}NMe{sub 2}]{sub 2}[Tb(L)(HCOO){sub 2}]{sub 2}·CB6·3H{sub 2}O (5). Complex 4 crystallizes as a 3D framework in which Tb(L){sup +} chains are connected by tetradentate CB6 molecules, while 5 unites a carboxylate-bridged anionic 2D planar assembly and layers of CB6 molecules with counter-cations held at both portals. - Graphical abstract: One- to three-dimensional assemblies are formed in terbium(III) complexes with 1,3-adamantanedicarboxylate obtained under solvo-hydrothermal conditions, these species including formate or acetate co-ligands formed in situ, or additional cucurbit[6]uril molecules. - Highlights: • We report structures of terbium(III) complexes with 1,3-adamantanedicarboxylate. • Solvents able to generate co-ligands or counter-ions in situ have been used. • A 3D species including additional cucurbituril molecules is decribed. • One species displays an alternation of metal–organic and organic sheets.

  15. The Nd-150(He-3,t) and Sm-150(t,He-3) reactions with applications to beta beta decay of Nd-150

    NARCIS (Netherlands)

    Guess, C. J.; Adachi, T.; Akimune, H.; Algora, A.; Austin, Sam M.; Bazin, D.; Brown, B. A.; Caesar, C.; Deaven, J. M.; Ejiri, H.; Estevez, E.; Fang, D.; Faessler, A.; Frekers, D.; Fujita, H.; Fujita, Y.; Fujiwara, M.; Grinyer, G. F.; Harakeh, M. N.; Hatanaka, K.; Herlitzius, C.; Hirota, K.; Hitt, G. W.; Ishikawa, D.; Matsubara, H.; Meharchand, R.; Molina, F.; Okamura, H.; Ong, H. J.; Perdikakis, G.; Rodin, V.; Rubio, B.; Shimbara, Y.; Suesoy, G.; Suzuki, T.; Tamii, A.; Thies, J. H.; Tur, C.; Verhanovitz, N.; Yosoi, M.; Yurkon, J.; Zegers, R. G. T.; Zenihiro, J.

    2011-01-01

    The Nd-150(3He,t) reaction at 140 MeV/u and Sm-150(t,He-3) reaction at 115 MeV/u were measured, populating excited states in Pm-150. The transitions studied populate intermediate states of importance for the (neutrinoless) beta beta decay of Nd-150 to Sm-150. Monopole and dipole contributions to the

  16. Complete Stokes polarimetry of magneto-optical Faraday effect in a terbium gallium garnet crystal at cryogenic temperatures.

    Science.gov (United States)

    Majeed, Hassaan; Shaheen, Amrozia; Anwar, Muhammad Sabieh

    2013-10-21

    We report the complete determination of the polarization changes caused in linearly polarized incident light due to propagation in a magneto-optically active terbium gallium garnet (TGG) single crystal, at temperatures ranging from 6.3 to 300 K. A 28-fold increase in the Verdet constant of the TGG crystal is seen as its temperature decreases to 6.3 K. In contrast with polarimetry of light emerging from a Faraday material at room temperature, polarimetry at cryogenic temperatures cannot be carried out using the conventional fixed polarizer-analyzer technique because the assumption that ellipticity is negligible becomes increasingly invalid as temperature is lowered. It is shown that complete determination of light polarization in such a case requires the determination of its Stokes parameters, otherwise inaccurate measurements will result with negative implications for practical devices.

  17. Development of Optical Isolators for Visible Light Using Terbium Aluminum Garnet (Tb3Al5O12) Single Crystals

    Science.gov (United States)

    Geho, Mikio; Takagi, Takashi; Chiku, Shinichiro; Fujii, Takashi

    2005-07-01

    We have recently reported the successful growth of incongruently melting terbium aluminum garnet (Tb3Al5O12; TAG) single crystals by the hybrid laser FZ (floating zone) method. Optical property evaluations confirmed a high transmittance and a larger Verdet constant than conventional Tb3Ga5O12 (TGG) crystals and/or Faraday glasses. In this study, we attempted to design, fabricate, and evaluate optical isolators in visible light through near-infrared (NIR) regions using TAG crystals. A finite element method (FEM) simulation of possible models led us to the preferable one based on a radially magnetized magnet. To realize this, we employed a pseudo-radially magnetized magnet. The target wavelengths of the prototype device were 408, 808, and 1064 nm. The typical extinction ratio was more than 30 dB and the insertion loss was less than 0.3 dB for AR-coated devices.

  18. Dicty_cDB: VFF150 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFF150 (Link to dictyBase) - - - Contig-U16455-1 VFF150Z (Link... to Original site) - - VFF150Z 378 - - - - Show VFF150 Library VF (Link to library) Clone ID VFF150 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/VF/VFF1-C/VFF150Q.Seq.d/ Representative seq. ID VFF15...0Z (Link to Original site) Representative DNA sequence >VFF150 (VFF150Q) /CSM/VF/VFF1-C/VFF150Q.Seq.d/ XXXXX...EGTXAVVLKNGXAXMVELTPSRPMCVXSFAEXPP LGRXAXRD Homology vs CSM-cDNA Score E Sequences producing significant ali

  19. A hydrometallurgical process for the recovery of terbium from fluorescent lamps: Experimental design, optimization of acid leaching process and process analysis.

    Science.gov (United States)

    Innocenzi, Valentina; Ippolito, Nicolò Maria; De Michelis, Ida; Medici, Franco; Vegliò, Francesco

    2016-12-15

    Terbium and rare earths recovery from fluorescent powders of exhausted lamps by acid leaching with hydrochloric acid was the objective of this study. In order to investigate the factors affecting leaching a series of experiments was performed in according to a full factorial plan with four variables and two levels (4 2 ). The factors studied were temperature, concentration of acid, pulp density and leaching time. Experimental conditions of terbium dissolution were optimized by statistical analysis. The results showed that temperature and pulp density were significant with a positive and negative effect, respectively. The empirical mathematical model deducted by experimental data demonstrated that terbium content was completely dissolved under the following conditions: 90 °C, 2 M hydrochloric acid and 5% of pulp density; while when the pulp density was 15% an extraction of 83% could be obtained at 90 °C and 5 M hydrochloric acid. Finally a flow sheet for the recovery of rare earth elements was proposed. The process was tested and simulated by commercial software for the chemical processes. The mass balance of the process was calculated: from 1 ton of initial powder it was possible to obtain around 160 kg of a concentrate of rare earths having a purity of 99%. The main rare earths elements in the final product was yttrium oxide (86.43%) following by cerium oxide (4.11%), lanthanum oxide (3.18%), europium oxide (3.08%) and terbium oxide (2.20%). The estimated total recovery of the rare earths elements was around 70% for yttrium and europium and 80% for the other rare earths. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Investigation of the luminescent properties of terbium-anthranilate complexes and application to the determination of anthranilic acid derivatives in aqueous solutions

    Energy Technology Data Exchange (ETDEWEB)

    Arnaud, N.; Georges, J

    2003-01-10

    The luminescent properties of terbium complexes with furosemide (FR), flufenamic (FF) acid, tolfenamic (TF) acid and mefenamic (MF) acid have been investigated in aqueous solutions. For all four compounds, complexation occurs when the carboxylic acid of the aminobenzoic group is dissociated and is greatly favoured in the presence of trioctylphosphine oxide as co-ligand and Triton X-100 as surfactant. Under optimum conditions, luminescence of the lanthanide ion is efficiently sensitised and the lifetime of the {sup 5}D{sub 4} resonance level of terbium in the complex is ranging between 1 and 1.9 ms, against 0.4 ms for the aqua ion. The sensitivity of the method for the determination of anthranilic acid derivatives is improved by one to two orders of magnitude with respect to that achieved using native fluorescence or terbium-sensitised luminescence in methanol. The limits of detection are 2x10{sup -10}, 5x10{sup -10} and 2x10{sup -9} mol l{sup -1} for flufenamic acid, furosemide and tolfenamic acid, and mefenamic acid, respectively, with within-run RSD values of less than 1%. The method has been applied to the determination of flufenamic acid in spiked calf sera with and without sample pretreatment. Depending on the method and the analyte concentration, the recovery was ranging between 83 and 113% and the lowest concentration attainable in serum samples was close to 1x10{sup -7} mol l{sup -1}.

  1. 32 CFR 150.19 - Reconsideration.

    Science.gov (United States)

    2010-07-01

    ... JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.19 Reconsideration. (a) The Court... for grant of review or certificate for review has not been filed with the United States Court of Appeals for the Armed Forces, or a record of trial for review under Article 67(b) has not been received by...

  2. 150 years old and still alive: eigenproblems

    NARCIS (Netherlands)

    Vorst, H.A. van der; Golub, Gene H.

    1997-01-01

    Linear eigenproblems continue to be an important and highly relevant area of research in numerical linear algebra. Therefore, it should be no surprise that numerical algorithms for eigenproblems are among the oldest known in the modern literature. In 1846, exactly 150 years ago, Jacobi [33] wrote

  3. The Origin of Species after 150 Years

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 2. The Origin of Species after 150 Years - One Hundred and Fifty Years without Darwin are Enough. Vidyanand Nanjundiah. General Article Volume 14 Issue 2 February 2009 pp 124-153 ...

  4. 38 CFR 51.150 - Physician services.

    Science.gov (United States)

    2010-07-01

    ...) PER DIEM FOR NURSING HOME CARE OF VETERANS IN STATE HOMES Standards § 51.150 Physician services. A... case of an emergency. (e) Physician delegation of tasks. (1) Except as specified in paragraph (e)(2) of... the delegation is prohibited under State law or by the facility's own policies. (Authority: 38 U.S.C...

  5. Dicty_cDB: AFF150 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available AF (Link to library) AFF150 (Link to dictyBase) - - - Contig-U13825-1 AFF150Z (Link... to Original site) - - AFF150Z 689 - - - - Show AFF150 Library AF (Link to library) Clone ID AFF150 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/AF/AFF1-C/AFF150Q.Seq.d/ Representative seq. ID AFF15...0Z (Link to Original site) Representative DNA sequence >AFF150 (AFF150Q) /CSM/AF/AFF1-C/AFF150Q.Seq.d/ XXXXX...D7-A/VFD715Q.Seq.d/ 1366 0.0 VFC622 (VFC622Q) /CSM/VF/VFC6-A/VFC622Q.Seq.d/ 1366 0.0 AFF150 (AFF150Q) /CSM/AF/AFF1-C/AFF1

  6. 45 CFR 150.421 - Appearance of counsel.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Appearance of counsel. 150.421 Section 150.421... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.421 Appearance of counsel... appearance. ...

  7. Dicty_cDB: CHF150 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHF150 (Link to dictyBase) - - - - CHF150P (Link to Original site) CHF150F 601 CHF...150Z 638 CHF150P 1219 - - Show CHF150 Library CH (Link to library) Clone ID CHF150 (Link... to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig - Original site URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHF...1-C/CHF150Q.Seq.d/ Representative seq. ID CHF150P (Link to... Original site) Representative DNA sequence >CHF150 (CHF150Q) /CSM/CH/CHF1-C/CHF150Q.Seq.d/ GTTAAAATAAGAGTAA

  8. Dicty_cDB: SLB150 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLB150 (Link to dictyBase) - - - Contig-U16273-1 SLB150Z (Link... to Original site) - - SLB150Z 739 - - - - Show SLB150 Library SL (Link to library) Clone ID SLB150 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLB1-C/SLB150Q.Seq.d/ Representative seq. ID SLB15...0Z (Link to Original site) Representative DNA sequence >SLB150 (SLB150Q) /CSM/SL/SLB1-C/SLB150Q.Seq.d/ XXXXX...nkiifckk Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value SLB150 (SLB150Q) /CSM/SL/SLB1-C/SLB

  9. 150 Years of Patent Office Practice

    OpenAIRE

    Josh Lerner

    2000-01-01

    An extensive theoretical literature has examined the impact of information problems on interactions between government bodies and private firms. One little-explored empirical testing ground is the patent system. This paper examines the administrative practices of patent offices in sixty countries over a 150-year period. I show that the usage of patent renewal fees and other mechanisms to grant discretion to patentees is consistent with theoretical suggestions. Nations where information asymme...

  10. Structural investigation and photoluminescent properties of gadolinium(III), europium(III) and terbium(III) 3-mercaptopropionate complexes.

    Science.gov (United States)

    Souza, E R; Mazali, I O; Sigoli, F A

    2014-01-01

    This work reports on the synthesis, crystallographic determination and spectroscopic characterization of gadolinium(III), terbium(III) and europium(III) 3-mercaptopropionate complexes, aqua-tris(3-mercaptopropionate)lanthanide(III)--[Ln(mpa)3(H2O)]. The Judd-Ofelt intensity parameters were experimentally determined from emission spectrum of the [Eu(mpa)3(H2O)]complex and they were also calculated from crystallographic data. The complexes are coordination polymers, where the units of each complex are linked together by carboxylate groups leading to an unidimensional and parallel chains that by chemical interactions form a tridimensional framework. The emission spectrum profile of the [Eu(mpa)3(H2O)] complex is discussed based on point symmetry of the europium(III) ion, that explains the bands splitting observed in its emission spectrum. Photoluminescent analysis of the [Gd(mpa)3(H2O)] complex show no efficient ligand excitation but an intense charge transfer band. The excitation spectra of the [Eu(mpa)3(H2O)] and [Tb(mpa)3(H2O)] complexes do not show evidence of energy transfer from the ligand to the excited levels of these trivalent ions. Therefore the emission bands are originated only by direct f-f intraconfigurational excitation of the lantanide(III) ions.

  11. Fluorometric determination of proteins using the terbium (III)-2-thenoyltrifluoroacetone-sodium dodecyl benzene sulfonate-protein system

    Energy Technology Data Exchange (ETDEWEB)

    Jia Zhen [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Department of Chemistry, Dezhou University, Dezhou 253023 (China); Yang Jinghe [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China)]. E-mail: yjh@sdu.edu.cn; Wu Xia [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Wang Fei [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Guo Changying [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China); Liu Shufang [Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100 (China)

    2006-12-15

    It is found that in hexamethylene tetramine (HMTA)-HCl buffer of pH=8.00, proteins can enhance the fluorescence of terbium (III) (Tb{sup 3+})-2-thenoyltrifluoroacetone (TTA)-sodium dodecyl benzene sulfonate (SDBS) system. Based on this, a sensitive method for the determination of proteins is proposed. The experiments indicate that under the optimum conditions, the enhanced fluorescence intensity is in proportion to the concentration of proteins in the range of 4.0x10{sup -9}-7.5x10{sup -6}g/mL for bovine serum albumin (BSA), 5.0x10{sup -9}-1.5x10{sup -5}g/mL for human serum albumin (HSA), 1.0x10{sup -8}-7.5x10{sup -6}g/mL for egg albumin (EA). Their detection limits (S/N=3) are 0.5, 0.8 and 2.0ng/mL, respectively. The interaction mechanism is also studied.

  12. Terbium to Quantum Dot FRET Bioconjugates for Clinical Diagnostics: Influence of Human Plasma on Optical and Assembly Properties

    Directory of Open Access Journals (Sweden)

    Niko Hildebrandt

    2011-10-01

    Full Text Available Förster resonance energy transfer (FRET from luminescent terbium complexes (LTC as donors to semiconductor quantum dots (QDs as acceptors allows extraordinary large FRET efficiencies due to the long Förster distances afforded. Moreover, time-gated detection permits an efficient suppression of autofluorescent background leading to sub-picomolar detection limits even within multiplexed detection formats. These characteristics make FRET-systems with LTC and QDs excellent candidates for clinical diagnostics. So far, such proofs of principle for highly sensitive multiplexed biosensing have only been performed under optimized buffer conditions and interactions between real-life clinical media such as human serum or plasma and LTC-QD-FRET-systems have not yet been taken into account. Here we present an extensive spectroscopic analysis of absorption, excitation and emission spectra along with the luminescence decay times of both the single components as well as the assembled FRET-systems in TRIS-buffer, TRIS-buffer with 2% bovine serum albumin, and fresh human plasma. Moreover, we evaluated homogeneous LTC-QD FRET assays in QD conjugates assembled with either the well-known, specific biotin-streptavidin biological interaction or, alternatively, the metal-affinity coordination of histidine to zinc. In the case of conjugates assembled with biotin-streptavidin no significant interference with the optical and binding properties occurs whereas the histidine-zinc system appears to be affected by human plasma.

  13. Evidence of mass exchange between inside and outside of sonoluminescing bubble in aqueous solution of terbium chloride

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Jinfu, E-mail: liang.shi2007@163.com [School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550001 (China); Chen, Weizhong, E-mail: wzchen@nju.edu.cn [The Key Laboratory of Modern Acoustics, Ministry of Education, Institution of Acoustics, Nanjing University, Nanjing 210093 (China); Wang, Xun; Yang, Jing; Chen, Zhan [The Key Laboratory of Modern Acoustics, Ministry of Education, Institution of Acoustics, Nanjing University, Nanjing 210093 (China)

    2016-12-16

    Highlights: • Time-resolved spectra of SBSL were obtained for Tb{sup 3+} ions emission lines. • Mass exchange between inside and outside of SL bubble was probed via Tb{sup 3+} ions lines. • The argon rectification hypothesis was tested by time-resolved spectra of SBSL. • The rate of mass exchange inside an SBSL bubble increases with increasing sound pressure. - Abstract: Spectra of single-bubble sonoluminescence (SBSL) were obtained for Tb{sup 3+} ions emission lines from bubbles in an aqueous solution of terbium chloride (TbCl{sub 3}). The spectra provide experimental evidence to prove that an air bubble driven by strong ultrasound will not eventually become a rectified pure argon bubble, which is not as predicted by the argon rectification hypothesis. The time-resolved spectra of SBSL show a mass exchange of material such as Tb{sup 3+} ions between the inside and outside of the bubble. With increasing sound pressure, the rate of mass exchange and the SBSL intensity increases.

  14. Optical properties and electrical transport of thin films of terbium(III bis(phthalocyanine on cobalt

    Directory of Open Access Journals (Sweden)

    Peter Robaschik

    2014-11-01

    Full Text Available The optical and electrical properties of terbium(III bis(phthalocyanine (TbPc2 films on cobalt substrates were studied using variable angle spectroscopic ellipsometry (VASE and current sensing atomic force microscopy (cs-AFM. Thin films of TbPc2 with a thickness between 18 nm and 87 nm were prepared by organic molecular beam deposition onto a cobalt layer grown by electron beam evaporation. The molecular orientation of the molecules on the metallic film was estimated from the analysis of the spectroscopic ellipsometry data. A detailed analysis of the AFM topography shows that the TbPc2 films consist of islands which increase in size with the thickness of the organic film. Furthermore, the cs-AFM technique allows local variations of the organic film topography to be correlated with electrical transport properties. Local current mapping as well as local I–V spectroscopy shows that despite the granular structure of the films, the electrical transport is uniform through the organic films on the microscale. The AFM-based electrical measurements allow the local charge carrier mobility of the TbPc2 thin films to be quantified with nanoscale resolution.

  15. Highly luminescent charge-neutral europium(iii) and terbium(iii) complexes with tridentate nitrogen ligands.

    Science.gov (United States)

    Senthil Kumar, Kuppusamy; Schäfer, Bernhard; Lebedkin, Sergei; Karmazin, Lydia; Kappes, Manfred M; Ruben, Mario

    2015-09-21

    We report on the synthesis of tridentate-nitrogen pyrazole-pyridine-tetrazole (L(1)H) and pyrazole-pyridine-triazole (L(2)H) ligands and their complexation with lanthanides (Ln = Gd(iii), Eu(iii) and Tb(iii)) resulting in stable, charge-neutral complexes Ln(L(1))3 and Ln(L(2))3, respectively. X-ray crystallographic analysis of the complexes with L(1) ligands revealed tricapped trigonal coordination geometry around the lanthanide ions. All complexes show bright photoluminescence (PL) in the solid state, indicating efficient sensitization of the lanthanide emission via the triplet states of the ligands. In particular, the terbium complexes show high PL quantum yields of 65 and 59% for L(1) and L(2), respectively. Lower PL efficiencies of the europium complexes (7.5 and 9%, respectively) are attributed to large energy gaps between the triplet states of the ligands and accepting levels of Eu(iii). The triplet state energy can be reduced by introducing an electron withdrawing (EW) group at the 4 position of the pyridine ring. Such substitution of L(1)H with a carboxylic ester (COOMe) EW group leads to a europium complex with increased PL quantum yield of 31%. A comparatively efficient PL of the complexes dissolved in ethanol indicates that the lanthanide ions are shielded against nonradiative deactivation via solvent molecules.

  16. Micelle enhanced and terbium sensitized spectrofluorimetric determination of danofloxacin in milk using molecularly imprinted solid phase extraction

    Science.gov (United States)

    Kaur, Kuldeep; Saini, Shivender Singh; Malik, Ashok Kumar; Singh, Baldev

    2012-10-01

    An efficient molecularly imprinted solid phase extraction (MISPE)-spectrofluorimetric method was developed to sensitively determine danofloxacin (DAN) in milk samples. Solid phase extraction procedure using MISPE cartridges was first performed on milk samples and then spectrofluorimetric determination was done at 546 nm using an excitation wavelength of 285 nm in presence of terbium and sodium dodecyl benzene sulfonate (SDBS). It was found that SDBS significantly enhanced the fluorescence intensity of the DAN-Tb3+ complex. Various factors affecting the fluorescence intensity of DAN-Tb3+-SDBS system were studied and conditions were optimized. The enhanced fluorescence intensity of the system (ΔF) showed a good linear relationship with the concentration of DAN over the range of 8.4 × 10-9-3.4 × 10-7 mol L-1 with a correlation coefficient of 0.9996. The detection limit was determined as 2.0 × 10-9 mol L-1 and the limit of quantification was determined as 6.5 × 10-9 mol L-1. The MISPE-spectrofluorimetric procedure was successfully applied to the determination of DAN in milk samples. The method is simple, rapid, sensitive and allows interference free determination of DAN in complex fluorescent matrices like milk. The method can be used to determine whether the DAN residues in milk exceed MRLs or not.

  17. Study of quantum dot based on tin/yttrium mixed oxide doped with terbium to be used as biomarker

    Energy Technology Data Exchange (ETDEWEB)

    Paganini, Paula P.; Felinto, Maria Claudia F.C.; Kodaira, Claudia A., E-mail: paulapaganini@usp.b, E-mail: mfelinto@ipen.b, E-mail: claudiakodaira@yahoo.co [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Brito, Hermi F., E-mail: hefbrito@iq.usp.b [Universidade de Sao Paulo (USP), SP (Brazil). Inst. de Quimica. Lab. de Elementos do Bloco f; Nunes, Luiz Antonio O., E-mail: luizant@ifsc.usp.b [Universidade de Sao Paulo (USP), Sao Carlos, SP (Brazil). Inst. de Fisica. Dept. de Fisica e Informatica

    2009-07-01

    Quantum dots (semiconductors nanocrystals) have brought a promising field to develop a new generation of luminescent biomarkers. The use of lanthanides ions as luminescent markers has many advantages, for example a security method, low cost, high specificity and also the luminescence can be promptly measured with high sensibility and accuracy. These luminescent dots are functionalized with biomolecules. For the luminophore particle to be connect with biologicals molecules (for example covalent antibody) is necessary a previous chemical treatment to modify luminophore particle surface and this process is called functionalization. A prior chemical treatment with changes on the surface luminophore particle is necessary to couple the luminophore to biological molecules. This process can be used as coating which can protect these particles from being dissolved by acid as well as provide functional groups for biological conjugation. This work presents a photoluminescence study of nanoparticles based on tin/yttrium mixed oxides doped with terbium (SnO{sub 2}/Y{sub 2}O{sub 3}:Tb{sup 3+}), synthesized by coprecipitation method. The nanoparticles were submitted to thermal treatment and characterized by X-Ray Powder Diffraction (XRD) that showed cassiterite phase formation and the influence of thermal treatment on nanoparticles structures. These nanoparticles going to be functionalized with a natural polysaccharide (chitosan) in order to form microspheres. These microspheres going to be irradiated with gamma radiation to sterilization and it can be evaluated if the nanoparticles are resistant to irradiation and they do not lose functionality with this process. (author)

  18. Terbium-doped gadolinium oxysulfide (Gd2O2S:Tb) scintillation-based polymer optical fibre sensor for real time monitoring of radiation dose in oncology

    Science.gov (United States)

    Lewis, E.; O'Keeffe, S.; Grattan, M.; Hounsell, A.; McCarthy, D.; Woulfe, P.; Cronin, J.; Mihai, L.; Sporea, D.; Santhanam, A.; Agazaryan, N.

    2014-05-01

    A PMMA based plastic optical fibre sensor for use in real time radiotherapy dosimetry is presented. The optical fibre tip is coated with a scintillation material, terbium-doped gadolinium oxysulfide (Gd2O2S:Tb), which fluoresces when exposed to ionising radiation (X-Ray). The emitted visible light signal penetrates the sensor optical fibre and propagates along the transmitting fibre at the end of which it is remotely monitored using a fluorescence spectrometer. The results demonstrate good repeatability, with a maximum percentage error of 0.5% and the response is independent of dose rate.

  19. Compact all-fiber optical Faraday components using 65-wt%-terbium-doped fiber with a record Verdet constant of -32 rad/(Tm).

    Science.gov (United States)

    Sun, L; Jiang, S; Marciante, J R

    2010-06-07

    A compact all-fiber Faraday isolator and a Faraday mirror are demonstrated. At the core of each of these components is an all-fiber Faraday rotator made of a 4-cm-long, 65-wt%-terbium-doped silicate fiber. The effective Verdet constant of the terbium-doped fiber is measured to be -32 rad/(Tm), which is 27 x larger than that of silica fiber. This effective Verdet constant is the largest value measured to date in any fiber and is 83% of the Verdet constant of commercially available crystal used in bulk optics-based isolators. Combining the all-fiber Faraday rotator with fiber polarizers results in a fully fusion spliced all-fiber isolator whose isolation is measured to be 19 dB. Combining the all-fiber Faraday rotator with a fiber Bragg grating results in an all-fiber Faraday mirror that rotates the polarization state of the reflected light by 88 +/- 4 degrees .

  20. Picomolar Traces of Americium(III) Introduce Drastic Changes in the Structural Chemistry of Terbium(III): A Break in the "Gadolinium Break".

    Science.gov (United States)

    Welch, Jan M; Müller, Danny; Knoll, Christian; Wilkovitsch, Martin; Giester, Gerald; Ofner, Johannes; Lendl, Bernhard; Weinberger, Peter; Steinhauser, Georg

    2017-10-16

    The crystallization of terbium 5,5'-azobis[1H-tetrazol-1-ide] (ZT) in the presence of trace amounts (ca. 50 Bq, ca. 1.6 pmol) of americium results in 1) the accumulation of the americium tracer in the crystalline solid and 2) a material that adopts a different crystal structure to that formed in the absence of americium. Americium-doped [Tb(Am)(H 2 O) 7 ZT] 2 ZT⋅10 H 2 O is isostructural to light lanthanide (Ce-Gd) 5,5'-azobis[1H-tetrazol-1-ide] compounds, rather than to the heavy lanthanide (Tb-Lu) 5,5'-azobis[1H-tetrazol-1-ide] (e.g., [Tb(H 2 O) 8 ] 2 ZT 3 ⋅6 H 2 O) derivatives. Traces of Am seem to force the Tb compound into a structure normally preferred by the lighter lanthanides, despite a 10 8 -fold Tb excess. The americium-doped material was studied by single-crystal X-ray diffraction, vibrational spectroscopy, radiochemical neutron activation analysis, and scanning electron microcopy. In addition, the inclusion properties of terbium 5,5'-azobis[1H-tetrazol-1-ide] towards americium were quantified, and a model for the crystallization process is proposed. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079 ...

  2. 46 CFR Appendix IV to Part 150 - Data Sheet

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Data Sheet IV Appendix IV to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, App. IV Appendix IV to Part 150—Data Sheet EC02FE91.080 EC02FE91.081 ...

  3. 32 CFR 150.1 - Name and seal.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Name and seal. 150.1 Section 150.1 National... JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.1 Name and seal. (a) The titles... Court is authorized a seal in the discretion of the Judge Advocate General concerned. The design of such...

  4. 38 CFR 17.150 - Prosthetic and similar appliances.

    Science.gov (United States)

    2010-07-01

    ... appliances. 17.150 Section 17.150 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Prosthetic, Sensory, and Rehabilitative Aids § 17.150 Prosthetic and similar appliances. Artificial limbs, braces, orthopedic shoes, hearing aids, wheelchairs, medical accessories, similar...

  5. 30 CFR 202.150 - Royalty on gas.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Royalty on gas. 202.150 Section 202.150 Mineral... Federal Gas § 202.150 Royalty on gas. (a) Royalties due on gas production from leases subject to the... part 206 of this title multiplied by the royalty rate in the lease. (b)(1) All gas (except gas...

  6. 45 CFR 150.443 - Standard of proof.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Standard of proof. 150.443 Section 150.443 Public... ENFORCEMENT IN GROUP AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.443 Standard of proof. (a... an affirmative defense. (b) The preponderance of the evidence standard applies to all cases before...

  7. 32 CFR 150.3 - Scope of review.

    Science.gov (United States)

    2010-07-01

    ... JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.3 Scope of review. In cases referred to it for review pursuant to Article 66, the Court may act only with respect to the findings and... 32 National Defense 1 2010-07-01 2010-07-01 false Scope of review. 150.3 Section 150.3 National...

  8. Kirchhoff's Law of Thermal Emission: 150 Years

    Directory of Open Access Journals (Sweden)

    Robitaille P.-M.

    2009-10-01

    Full Text Available In this work, Kirchhoff's law (Kirchhoff G. Monatsberichte der Akademie der Wissenschaften zu Berlin, sessions of Dec. 1859, 1860, 783-787 is being revisited not only to mark its 150th anniversary but, most importantly, to highlight serious overreaching in its formulation. At the onset, Kirchhoff's law correctly outlines the equivalence between emission and absorption for an opaque object under thermal equilibrium. This same conclusion had been established earlier by Balfour Stewart (Stewart B. Trans. Royal Soc. Edinburgh, 1858, v.22(1, 1-20. However, Kirchhoff extends the treatment beyond his counterpart, stating that cavity radiation must always be black, or normal: depending only on the temperature and the frequency of observation. This universal aspect of Kirchhoff's law is without proper basis and constitutes a grave distortion of experimental reality. It is readily apparent that cavities made from arbitrary materials ($varepsilon < 1$ are never black. Their approach to such behavior is being driven either by the blackness of the detector, or by black materials placed near the cavity. Ample evidence exists that radiation in arbitrary cavities is sensitive to the relative position of the detectors. In order to fully address these issues, cavity radiation and the generalization of Kirchhoff's law are discussed. An example is then taken from electromagnetics, at microwave frequencies, to link results in the resonant cavity with those inferred from the consequences of generalization.

  9. Kirchhoff's Law of Thermal Emission: 150 Years

    Directory of Open Access Journals (Sweden)

    Robitaille P.-M.

    2009-10-01

    Full Text Available n this work, Kirchhoff’s law (Kirchhoff G. Monatsberichte der Akademie der Wis- senschaften zu Berlin , sessions of Dec. 1859, 1860, 783–787 is being revisited not only to mark its 150th anniversary but, most importantly, to highlight serious overreaching in its formulation. At the onset, Kirchhoff’s law correctly outlines the equivalence be- tween emission and absorption for an opaque object under thermal equilibrium. This same conclusion had been established earlier by Balfour Stewart (Stewart B. Trans. Royal Soc. Edinburgh , 1858, v. 22(1, 1–20. However, Kirchhoff extends the treatment beyond his counterpart, stating that cavity radiation must always be black, or normal: depending only on the temperature and the frequency of observation. This universal aspect of Kirchhoff’s law is without proper basis and constitutes a grave distortion of experimental reality. It is readily apparent that cavities made from arbitrary materials ( " < 1 are never black. Their approach to such behavior is being driven either by the blackness of the detector, or by black materials placed near the cavity. Ample evidence exists that radiation in arbitrary cavities is sensitive to the relative position of the de- tectors. In order to fully address these issues, cavity radiation and the generalization of Kirchhoff’s law are discussed. An example is then taken from electromagnetics, at microwave frequencies, to link results in the resonant cavity with those inferred from the consequences of generalization.

  10. Preserving & Serving 150 years of KNMI data

    Science.gov (United States)

    van de Vegte, J.; Som de Cerff, W. J.

    2012-04-01

    The Royal Netherlands Meteorological Institute (KNMI) has over 150 years of knowledge and gathered information related to weather, Climate and Seismology. A huge part of this information is from numerical models, insitu sensor networks and remote sensing satellites. This digital collection is mostly internal only available and is a collection of non searchable , non standardized file formats, lacking documentation and has no references to scientific publications. With the Dutch funded KNMI Data Centre (KDC) project we aim to tackle al these issues. In the project a user driven development approach with SCRUM is chosen to get maximum user involvement in a relative short development timeframe. Building on open standards and proven opensource technology (which includes in-house developed software like ADAGUC WMS and Portal) should result in a solid first release in 2012-Q3. This presentation will focus on the aspects of developing the KDC relating to its technical challenges, the human factor and the development strategy to come to a future-proof centre that will preserve our data en make it usable for the community.

  11. Crystal structures of two mononuclear complexes of terbium(III) nitrate with the tripodal alcohol 1,1,1-tris-(hy-droxy-meth-yl)propane.

    Science.gov (United States)

    Gregório, Thaiane; Giese, Siddhartha O K; Nunes, Giovana G; Soares, Jaísa F; Hughes, David L

    2017-02-01

    Two new mononuclear cationic complexes in which the TbIII ion is bis-chelated by the tripodal alcohol 1,1,1-tris-(hy-droxy-meth-yl)propane (H3LEt, C6H14O3) were prepared from Tb(NO3)3·5H2O and had their crystal and mol-ecular structures solved by single-crystal X-ray diffraction analysis after data collection at 100 K. Both products were isolated in reasonable yields from the same reaction mixture by using different crystallization conditions. The higher-symmetry complex dinitratobis[1,1,1-tris-(hy-droxy-meth-yl)propane]-terbium(III) nitrate di-meth-oxy-ethane hemisolvate, [Tb(NO3)2(H3LEt)2]NO3·0.5C4H10O2, 1, in which the lanthanide ion is 10-coordinate and adopts an s-bicapped square-anti-prismatic coordination geometry, contains two bidentate nitrate ions bound to the metal atom; another nitrate ion functions as a counter-ion and a half-mol-ecule of di-meth-oxy-ethane (completed by a crystallographic twofold rotation axis) is also present. In product aqua-nitratobis[1,1,1-tris-(hy-droxy-meth-yl)propane]-terbium(III) dinitrate, [Tb(NO3)(H3LEt)2(H2O)](NO3)2, 2, one bidentate nitrate ion and one water mol-ecule are bound to the nine-coordinate terbium(III) centre, while two free nitrate ions contribute to charge balance outside the tricapped trigonal-prismatic coordination polyhedron. No free water mol-ecule was found in either of the crystal structures and, only in the case of 1, di-meth-oxy-ethane acts as a crystallizing solvent. In both mol-ecular structures, the two tripodal ligands are bent to one side of the coordination sphere, leaving room for the anionic and water ligands. In complex 2, the methyl group of one of the H3LEt ligands is disordered over two alternative orientations. Strong hydrogen bonds, both intra- and inter-molecular, are found in the crystal structures due to the number of different donor and acceptor groups present.

  12. The response behavior of PPy-DB18C6 electrode to terbium(III in acetonitrile and its thermodynamic application

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Arbab Zavar

    2016-11-01

    Full Text Available Polypyrrole modified electrode prepared by electropolymerization of pyrrole in the presence of a complexing ligand, dibenzo-18-crown-6(DB18C6, was prepared and investigated as a Tb3+-selective electrode in acetonitrile. The potentiometric response of the electrode was linear within the Tb3+ concentration range 1 × 10−5–1 × 10−2 M with a Nernstian slope of 20.9 mVdecade−1 in AN. The electrode was applied to study the complexation of the terbium(III ion in acetonitrile with such other basic aprotic solvent molecules (D as dimethyl sulfoxide, N,N-dimethyl formamide, propylene carbonate and pyridine. The successive complex formation constant (βi and Gibbs energies of transfer (ΔGtr of Tb3+ in AN in relation to such D were obtained.

  13. Luminescence and Magnetic Properties of Two Three-Dimensional Terbium and Dysprosium MOFs Based on Azobenzene-4,4′-Dicarboxylic Linker

    Directory of Open Access Journals (Sweden)

    Belén Fernández

    2016-02-01

    Full Text Available We report the in situ formation of two novel metal-organic frameworks based on terbium and dysprosium ions using azobenzene-4,4′-dicarboxylic acid (H2abd as ligand, synthesized by soft hydrothermal routes. Both materials show isostructural three-dimensional networks with channels along a axis and display intense photoluminescence properties in the solid state at room temperature. Textural properties of the metal-organic frameworks (MOFs have been fully characterized although no appreciable porosity was obtained. Magnetic properties of these materials were studied, highlighting the dysprosium material displays slightly frequency-dependent out of phase signals when measured under zero external field and under an applied field of 1000 Oe.

  14. Studi Pengaman Busbar 150 Kv pada Gardu Induk Siantan

    OpenAIRE

    Julian Maruli Torang Manurung

    2013-01-01

    Berdasarkan data real di lapangan pada tanggal 1 agustus 2012 pukul 16:55 wib telah terjadi gangguan pada busbar 150 kV di sistem sistem kelistrikan PT PLN (Persero) Area Pengatur Distribusi dan Penyaluran (APDP) Kalimantan Barat, yaitu masuknya kawat layangan ke switchyard dan mengenai busbar 150 kV, sehingga mengakibatkan gangguan tersebut tidak dapat dilokalisir (gangguan menjadi meluas). Maka pada penelitian ini dilakukan studi sistem proteksi pengaman busbar 150 kV, yang dimulai dengan p...

  15. Luminescent europium and terbium complexes of dipyridoquinoxaline and dipyridophenazine ligands as photosensitizing antennae: structures and biological perspectives.

    Science.gov (United States)

    Dasari, Srikanth; Patra, Ashis K

    2015-12-14

    The europium(III) and terbium(III) complexes, namely [Eu(dpq)(DMF)2(NO3)3] (1), [Eu(dppz)2(NO3)3] (2), [Tb(dpq)(DMF)2Cl3] (3), and [Tb(dppz)(DMF)2Cl3] (4), where dipyrido[3,2-d:2',3'-f]quinoxaline (dpq in 1 and 3), dipyrido[3,2-a:2',3'-c]phenazine (dppz in 2 and 4) and N,N'-dimethylformamide (DMF) have been isolated, characterized from their physicochemical data, luminescence studies and their interaction with DNA, serum albumin protein and photo-induced DNA cleavage activity are studied. The X-ray crystal structures of complexes 1-4 show discrete mononuclear Ln(3+)-based structures. The Eu(3+) in [Eu(dpq)(DMF)2(NO3)3] (1) and [Eu(dppz)2(NO3)3] (2) as [Eu(dppz)2(NO3)3]·dppz (2a) adopts a ten-coordinated bicapped dodecahedron structure with a bidentate N,N-donor dpq ligand, two DMF and three NO3(-) anions in 1 and two bidentate N,N-donor dppz ligands and three NO3(-) anions in 2. Complexes 3 and 4 show a seven-coordinated mono-capped octahedron structure where Tb(3+) contains bidentate dpq/dppz ligands, two DMF and three Cl(-) anions. The complexes are highly luminescent in nature indicating efficient photo-excited energy transfer from the dpq/dppz antenna to Ln(3+) to generate long-lived emissive excited states for characteristic f → f transitions. The time-resolved luminescence spectra of complexes 1-4 show typical narrow emission bands attributed to the (5)D0 → (7)F(J) and (5)D4 → (7)F(J) f-f transitions of Eu(3+) and Tb(3+) ions respectively. The number of inner-sphere water molecules (q) was determined from luminescence lifetime measurements in H2O and D2O confirming ligand-exchange reactions with water in solution. The complexes display significant binding propensity to the CT-DNA giving binding constant values in the range of 1.0 × 10(4)-6.1 × 10(4) M(-1) in the order 2, 4 (dppz) > 1, 3 (dpq). DNA binding data suggest DNA groove binding with the partial intercalation nature of the complexes. All the complexes also show binding propensity (K(BSA)

  16. 21 CFR 146.150 - Canned concentrated orange juice.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Canned concentrated orange juice. 146.150 Section... Fruit Juices and Beverages § 146.150 Canned concentrated orange juice. (a) Canned concentrated orange... labeling of ingredients prescribed for frozen concentrated orange juice by § 146.146, except that it is not...

  17. 22 CFR 1600.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-04-01

    ....150 Section 1600.150 Foreign Relations JAPAN-UNITED STATES FRIENDSHIP COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAPAN-UNITED STATES FRIENDSHIP... action that it can demonstrate would result in a fundamental alteration in the nature of a program or...

  18. 25 CFR 150.9 - Land status maps.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Land status maps. 150.9 Section 150.9 Indians BUREAU OF... status maps. The Land Titles and Records Offices shall prepare and maintain maps of all reservations and... service responsibilities. Base maps shall be prepared from plats of official survey made by the General...

  19. African American Accounting Majors and the 150-hr Requirement

    Science.gov (United States)

    Booker, Quinton; Hill, Cecil L.; Wright, Carl

    2010-01-01

    The study provides information on African American accounting majors' views regarding 150-hr issues. The authors collected data from 152 students at two schools. Students at one school supported the requirement while those at the other school did not. However, students believed that the 150-hr requirement enhances the quality of certified public…

  20. 40 CFR 52.150 - Yavapai-Apache Reservation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Yavapai-Apache Reservation. 52.150... (CONTINUED) APPROVAL AND PROMULGATION OF IMPLEMENTATION PLANS Arizona § 52.150 Yavapai-Apache Reservation. (a... applicable to the Yavapai-Apache Reservation, pursuant to § 52.21(a). (b) In accordance with section 164 of...

  1. 10 CFR 150.20 - Recognition of Agreement State licenses.

    Science.gov (United States)

    2010-01-01

    ... of 10 CFR parts 19, 20 and 71 and subparts C through H of part 34, §§ 39.15 and 39.31 through 39.77... § 150.20, see the List of CFR Sections Affected, which appears in the Finding Aids section of the... 150.20 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXEMPTIONS AND CONTINUED REGULATORY AUTHORITY...

  2. 21 CFR 150.160 - Fruit preserves and jams.

    Science.gov (United States)

    2010-04-01

    ... fruits in which the weight of each is not less than one-fifth and the weight of apple is not more than... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Fruit preserves and jams. 150.160 Section 150.160... FOR HUMAN CONSUMPTION FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS Requirements for...

  3. 49 CFR 176.150 - Radio and radar.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Radio and radar. 176.150 Section 176.150... radar. (a) Except as provided in paragraph (b) of this section, when Class 1 (explosive) materials... as radio and radar transmitters are deenergized by opening the main switches controlling the sources...

  4. 27 CFR 646.150 - Retention of records.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Retention of records. 646.150 Section 646.150 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE MISCELLANEOUS REGULATIONS RELATING TO ALCOHOL AND TOBACCO CONTRABAND...

  5. 21 CFR 173.150 - Milk-clotting enzymes, microbial.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Milk-clotting enzymes, microbial. 173.150 Section... HUMAN CONSUMPTION Enzyme Preparations and Microorganisms § 173.150 Milk-clotting enzymes, microbial. Milk-clotting enzyme produced by pure-culture fermentation process may be safely used in the production...

  6. 33 CFR 80.150 - Block Island, RI.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Block Island, RI. 80.150 Section... NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.150 Block Island, RI. The 72 COLREGS shall apply on the harbors of Block Island. ...

  7. 21 CFR 150.141 - Artificially sweetened fruit jelly.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Artificially sweetened fruit jelly. 150.141 Section 150.141 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...) A vinegar, lemon juice, lime juice, citric acid, lactic acid, malic acid, tartaric acid, fumaric...

  8. Dicty_cDB: VFB150 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFB150 (Link to dictyBase) - - - - VFB150Z (Link to Original site) - - VFB150Z 149...149 - - - - Show VFB150 Library VF (Link to library) Clone ID VFB150 (Link to dictyBase) Atlas ID - NBRP...BI946540 |BI946540.1 bEST145.3' Honeybee brain cDNA library Apis mellifera cDNA 3' similar to heat shock cognate...BB170011B10C03 Bee Brain Normalized/Subtracted Library, BB17 Apis mellifera cDNA clone BB170011B10C03...morsitans (Tseatse fly) EST from adult infected midgut library, clone Tse60h02_q1c. 109 1e-20 1 BX569171 |BX569171

  9. Spin Waves in Terbium

    DEFF Research Database (Denmark)

    Jensen, J.; Houmann, Jens Christian Gylden

    1975-01-01

    The selection rules for the linear couplings between magnons and phonons propagating in the c direction of a simple basal-plane hcp ferromagnet are determined by general symmetry considerations. The acoustic-optical magnon-phonon interactions observed in the heavy-rare-earth metals have been expl...... by Liu. The coupled magnon—transverse-phonon system for the c direction of Tb is analyzed in detail, and the strengths of the couplings are deduced as a function of wave vector by combining the experimental studies with the theory....

  10. Spin Waves in Terbium

    DEFF Research Database (Denmark)

    Jensen, J.; Houmann, Jens Christian Gylden; Bjerrum Møller, Hans

    1975-01-01

    The energies of spin waves propagating in the c direction of Tb have been studied by inelastic neutron scattering, as a function of a magnetic field applied along the easy and hard directions in the basal plane, and as a function of temperature. From a general spin Hamiltonian, consistent...... with the symmetry, we deduce the dispersion relation for the spin waves in a basal-plane ferromagnet. This phenomenological spin-wave theory accounts for the observed behavior of the magnon energies in Tb. The two q⃗-dependent Bogoliubov components of the magnon energies are derived from the experimental results...

  11. Linnugripp võib tappa 150 miljonit inimest / Kaarel Kaas

    Index Scriptorium Estoniae

    Kaas, Kaarel, 1978-

    2005-01-01

    Seni kanasid, kalkuneid ning teisi kodu- ja metslinde tapnud linnugripp ähvardab inimkonda viimase saja aasta laastavaima taudipuhanguga, mis halvimal juhul võib tappa kuni 150 miljonit inimest, hoiatas ÜRO

  12. EAS kulutab 150 miljonit telesaadetele ja messidele / Martin Hanson

    Index Scriptorium Estoniae

    Hanson, Martin, 1984-

    2008-01-01

    EAS kulutab välisturistide Eestisse meelitamiseks 150 miljonit krooni, millega finantseeritakse telesaateid, messidel osalemist ja ajakirjanike pressireise. Vt. samas: Kampaania maksumus; Eesti tutvustuse üritusi. Kommenteerib Mari Loorens-Timmo

  13. 32 CFR 150.10 - Request for appellate defense counsel.

    Science.gov (United States)

    2010-07-01

    ... PERTAINING TO MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.10 Request... does not waive appellate review pursuant to Rule for Courts-Martial 1110 shall, within 10 days after...

  14. Gulf of Mexico dead zone - the last 150 years

    Science.gov (United States)

    Osterman, Lisa; Swarzenski, P.W.; Poore, R.Z.

    2006-01-01

    'Gulf of Mexico Dead Zone-The Last 150 Years' discusses the dead zone that forms seasonally in the northern Gulf of Mexico when subsurface waters become depleted in dissolved oxygen and cannot support most life.

  15. 150 MeV fixed field alternating gradient (FFAG) accelerator

    CERN Document Server

    Nakano, J

    2002-01-01

    150 MeV FFAG accelerator is prototype for practical use. Fundamental development of FFAG, research of FFAG accelerator and its application for therapy are investigated. 150 MeV ring consists of 12 sector magnets. The distribution of magnetic field of 12 sector magnets is almost same. 12 MeV proton beam is generated by cyclotron and injection to 150 MeV FFAG. The injection system consists of 2 bump magnets, kicker magnet and septum electrode. RF accelerating cavity system using high-permeability magnetic substance with high magnetic permeability accelerates proton beam to 150 MeV, then the first operation aims at 250 Hz. Return Yoke Free magnet was developed for adjustment. 150 MeV FFAG magnet is constructed and 12 MeV proton beam acceleration is conformed. The final state of 150 MeV FFAG magnet is explained by calculation results. On cancer therapy by proton beam, the three dimensions spot scan method is proposed. (S.Y.)

  16. Synthesis and crystal structure of terbium(III) meta-oxoborate Tb(BO{sub 2}){sub 3} ({identical_to} TbB{sub 3}O{sub 6}); Synthese und Kristallstruktur von Terbium(III)-meta-Oxoborat Tb(BO{sub 2}){sub 3} ({identical_to} TbB{sub 3}O{sub 6})

    Energy Technology Data Exchange (ETDEWEB)

    Nikelski, Tanja; Schleid, Thomas [Institut fuer Anorganische Chemie der Universitaet Stuttgart (Germany)

    2003-06-01

    The terbium meta-oxoborate Tb(BO{sub 2}){sub 3} ({identical_to} TbB{sub 3}O{sub 6}) is obtained as single crystals by the reaction of terbium, Tb{sub 4}O{sub 7} and TbCl{sub 3} with an excess of B{sub 2}O{sub 3} in gastight sealed platinum ampoules at 950 C after three weeks. The compound appears to be air- and water-resistant and crystallizes as long, thin, colourless needles which tend to growth-twinning due to their marked fibrous habit. The crystal structure of Tb(BO{sub 2}){sub 3} (orthorhombic, Pnma; a = 1598.97(9), b = 741.39(4), c = 1229.58(7) pm; Z = 16) contains strongly corrugated oxoborate layers {sub {infinity}}{sup 2}{l_brace}(BO{sub 2}){sup -}{r_brace} built of vertex-linked [BO{sub 4}]{sup 5-} tetrahedra (d(B-O) = 143 - 154 pm, and angsph;(O-B-O) = 102-115 ) which spread out parallel (100). The four crystallographically different Tb{sup 3+} cations all exhibit coordination numbers of eight towards the oxygen atoms (d(Tb-O) = 228-287 pm). The corresponding metal cation polyhedra [TbO{sub 8}]{sup 13+} too convene to layers (composition: {sub {infinity}}{sup 2}{l_brace}(Tb{sub 2}O{sub 11}){sup 16-}{r_brace}) which are likewise oriented parallel to the (100) plane. (Abstract Copyright [2003], Wiley Periodicals, Inc.) [German] Das Terbium-meta-Oxoborat Tb(BO{sub 2}){sub 3} ({identical_to} TbB{sub 3}O{sub 6}) entsteht einkristallin bei der Reaktion von Terbium, Tb{sub 4}O{sub 7} und TbCl{sub 3} mit einem Ueberschuss von B{sub 2}O{sub 3} in gasdicht verschlossenen Platinampullen nach drei Wochen bei 950 C. Die Verbindung ist luft- und wasserstabil und faellt in langen, duennen, farblosen Nadeln an, die aufgrund ihres ausgepraegt faserigen Habitus zur Wachstumsverzwillingung neigen. Die Kristallstruktur von Tb(BO{sub 2}){sub 3} (orthorhombisch, Pnma; a = 1598, 97(9), b = 741, 39(4), c = 1229, 58(7) pm; Z = 16) enthaelt parallel (100) verlaufende, stark gewellte Oxoborat-Schichten {sub {infinity}}{sup 2}{l_brace}(BO{sub 2}){sup -}{r_brace} aus

  17. An integrated logic system for time-resolved fluorescent "turn-on" detection of cysteine and histidine base on terbium (III) coordination polymer-copper (II) ensemble.

    Science.gov (United States)

    Xue, Shi-Fan; Lu, Ling-Fei; Wang, Qi-Xian; Zhang, Shengqiang; Zhang, Min; Shi, Guoyue

    2016-09-01

    Cysteine (Cys) and histidine (His) both play indispensable roles in many important biological activities. An enhanced Cys level can result in Alzheimer's and cardiovascular diseases. Likewise, His plays a significant role in the growth and repair of tissues as well as in controlling the transmission of metal elements in biological bases. Therefore, it is meaningful to detect Cys and His simultaneously. In this work, a novel terbium (III) coordination polymer-Cu (II) ensemble (Tb(3+)/GMP-Cu(2+)) was proposed. Guanosine monophosphate (GMP) can self-assemble with Tb(3+) to form a supramolecular Tb(3+) coordination polymer (Tb(3+)/GMP), which can be suited as a time-resolved probe. The fluorescence of Tb(3+)/GMP would be quenched upon the addition of Cu(2+), and then the fluorescence of the as-prepared Tb(3+)/GMP-Cu(2+) ensemble would be restored again in the presence of Cys or His. By incorporating N-Ethylmaleimide and Ni(2+) as masking agents, Tb(3+)/GMP-Cu(2+) was further exploited as an integrated logic system and a specific time-resolved fluorescent "turn-on" assay for simultaneously sensing His and Cys was designed. Meanwhile it can also be used in plasma samples, showing great potential to meet the need of practical application. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Synthesis and photoluminescence properties of cerium-doped terbium-yttrium aluminum garnet phosphor for white light-emitting diodes applications

    Science.gov (United States)

    Wang, Jun; Han, Tao; Lang, Tianchun; Tu, Mingjing; Peng, Lingling

    2015-11-01

    Cerium-doped terbium-yttrium aluminum garnet phosphors were synthesized using the solid-state reaction method. The crystalline phase, morphology, and photoluminescence properties were characterized by x-ray diffraction (XRD), scanning electron microscope (SEM), and fluorescence spectrophotometer, respectively. The XRD results indicate that with an increase of the amount of x (Tb3+), all of the samples have a pure garnet crystal structure without secondary phases. The SEM images reveal that the samples are composed of sphere-like crystallites, which exhibit different degrees of agglomeration. The luminescent properties of Ce ions in )Al5O12∶Ce0.1 have been studied, and it was found that the emission band shifted toward a longer wavelength. The redshift is attributed to the lowering of the 5d energy level centroid of Ce, which can be explained by the nephelauxetic effect and compression effect. These phosphors were coated on blue light-emitting diode (LED) chips to fabricate white light-emitting diodes (WLEDs), and their color-rendering indices, color temperatures, and luminous efficiencies were measured. As a consequence of the addition of Tb, the blue LED pumped )Al5O12∶Ce0.1 phosphors WLEDs showed good optical properties.

  19. Study on the fluorescent enhancement effect in terbium-gadolinium-protein-sodium dodecyl benzene sulfonate system and its application on sensitive detection of protein at nanogram level.

    Science.gov (United States)

    Sun, Changxia; Yang, Jinghe; Wu, Xia; Liu, Shufang; Su, Benyu

    2004-08-01

    The co-luminescence effect in a terbium-gadolinium-protein-sodium dodecyl benzene sulfonate (SDBS) system is reported here. Based on it, the sensitive quantitative analysis of protein at nanogram levels is established. The co-luminescence mechanism is studied using fluorescence, resonance light scattering (RLS), absorption spectroscopy and NMR measurement. It is considered that protein could be unfolded by SDBS, then a efficacious intramolecular fluorescent energy transfer occurs from unfolded protein to rare earth ions through SDBS acting as a "transfer bridge" to enhance the emission fluorescence of Tb3+ in this ternary complex of Tb-SDBS-BSA, where energy transfer from protein to SDBS by aromatic ring stacking is the most important step. Cooperating with the intramolecular energy transfer above is the intermolecular energy transfer between the simultaneous existing complexes of both Tb3+ and Gd3+. The fluorescence quantum yield is increased by an energy-insulating sheath, which is considered to be another reason for the resulting enhancement of the fluorescence. Förster theory is used to calculate the distribution of enhancing factors and has led to a greater understanding of the mechanisms of energy transfer.

  20. [Studies on luminescence properties of seven ternary complexes of terbium with 1,10-phenanthroline and benzoic acid and its derivatives].

    Science.gov (United States)

    Gao, Zhi-hua; Wang, Shu-ping; Liu, Cui-ge; Ma, Rui-xia; Wang, Rui-fen

    2006-04-01

    Seven ternary complexes of Tb(III) were synthesized with benzoic acid (BA), o-, m-, p-methylbenzoic acid (o-MBA, m-MBA, p-MBA), and o-, m-, p-methoxybenzoic acid (o-MOBA, m-MOBA, p-MOBA) as the first ligand, and 1,10-phenanthroline (phen) as the second ligand. The content of C, H and N were measured by using a Flash-EA model 1112 elemental analyzer. Excitation and luminescence spectra of the title solid complexes were recorded by using a Hitachi F-4500 fluorescence spectrophotometer at room temperature. The effects of different varieties and different positions of replacing benzoic acid as the first ligand on fluorescence properties of the ternary complexes of terbium were discussed. The results indicated that the intensity of 5D4-->7F6 (489 nm) and 5D4-->7F5 (545 nm) of substituting benzoic acid complexes was stronger than benzoic acid. Three ternary complexes of Tb(III) with o-, m-, p-methylbenzoic acid showed emission intensity in the consecution: Tb(o-MBA)3 phenMOBA)3phen x H2O>Tb(m-MOBA)3phen x H2O>Tb(p-MOBA)3 phen.

  1. Phenotype abnormality: 150 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 150 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u656i decreased efficiency... in organ named portion of meristem tissue during process named cell division ... portion of meristem tissue ... decreased efficiency ... cell division ...

  2. 32 CFR 150.13 - Notice of appearance of counsel.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Notice of appearance of counsel. 150.13 Section... appearance of counsel. Military and civilian appellate counsel shall file a written notice of appearance with... constitutes notice of appearance of such counsel. ...

  3. The 150-Hour Requirement for CPA Licensure: One Institution's Response

    Science.gov (United States)

    Larkin, Joseph M.

    2014-01-01

    Virtually all states now require candidates for the Certified Public Accountant (CPA) examination and subsequent licensure to have completed 150 semester hours of college education. The rationale behind this requirement is to improve the preparation of students entering the profession and to increase their chances of successful completion of the…

  4. 150 Years of Italian CO2 Emissions and Economic Growth

    DEFF Research Database (Denmark)

    Annicchiarico, Barbara; Bennato, Anna Rita; Chini, Emilio Zanetti

    This paper examines the relationship between economic growth and carbon dioxide emissions in Italy considering the developments in a 150-year time span. Using several statistical techniques, we find that GDP growth and carbon dioxide emissions are strongly interrelated, with a dramatic change...

  5. 27 CFR 28.150 - Charges and credits on bond.

    Science.gov (United States)

    2010-04-01

    ... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXPORTATION OF ALCOHOL Removal of Beer and Beer Concentrate...-Trade Zone § 28.150 Charges and credits on bond. The removal of beer concentrate from the brewery..., of an amount equal to the tax which would be due on removal for consumption or sale, including...

  6. Adsorption gas chromatography with 150-ms {sup 216}Po

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, A. [Bern Univ. (Switzerland); Gaeggeler, H.W.; Tuerler, A. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-09-01

    A gas chromatography apparatus was developed, which allows experiments with volatile radionuclides having shorter half-lives than one second. This apparatus was tested with the 150-ms isotope {sup 216}Po. Experimental data were compared with a Monte Carlo model to determine the adsorption enthalpy {Delta}H{sub a}. (author) 2 figs., 2 refs.

  7. 32 CFR 150.22 - Petitions for new trial.

    Science.gov (United States)

    2010-07-01

    ... MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.22 Petitions for new... counsel for the accused, a petition for new trial submitted while the accused's case is undergoing review by a Court of Criminal Appeals shall be filed with an original and two copies and shall comply with...

  8. 33 CFR 150.614 - When is protective clothing required?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false When is protective clothing... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Clothing § 150.614 When is protective clothing required? The deepwater port operator must ensure that personnel...

  9. TS-05: 150 lines of java with high architectural complexity

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2005-01-01

    In the short time span available in a software architecture course, it is difficult to find a software system that is both interesting from an architectural perspective and so small that it does not overwhelm the students.We present TS-05 which is a bare 150 line Java "toy-system" that never...

  10. 20 CFR 655.150 - Interstate clearance of job order.

    Science.gov (United States)

    2010-04-01

    ... elapsed, and must refer each qualified U.S. worker who applies (or on whose behalf an application is made... EMPLOYMENT OF FOREIGN WORKERS IN THE UNITED STATES Labor Certification Process for Temporary Agricultural Employment in the United States (H-2A Workers) Post-Acceptance Requirements § 655.150 Interstate clearance of...

  11. 37 CFR 150.3 - Submission of requests.

    Science.gov (United States)

    2010-07-01

    ... proclamation shall include: (1) A copy of the foreign law or legal rulings that provide protection for U.S... administrative orders. (5) All copies of laws, legal rulings, regulations or administrative orders submitted must... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Submission of requests. 150.3...

  12. 33 CFR 162.150 - Maumee Bay and River, Ohio.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Maumee Bay and River, Ohio. 162... (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.150 Maumee Bay and River, Ohio. (a) In Maumee Bay (lakeward of Maumee River Lighted Buoy 49(L/L No. 770)), no vessel greater than...

  13. 150 K. Visweswara Rao and T. R. Seshadri

    Indian Academy of Sciences (India)

    150 K. Visweswara Rao and T. R. Seshadri was then effected under ordinary pressure up to a temperature of 240°. It was connected again to the pump and the distillation carried out at a pressure of 40 mm. Three fractions were collected: (1) below 160", (2) 160—70“ and (3) 17045". The last fraction corresponded to ...

  14. 38 CFR 59.150 - Domiciliary care requirements.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Domiciliary care... (CONTINUED) GRANTS TO STATES FOR CONSTRUCTION OR ACQUISITION OF STATE HOMES § 59.150 Domiciliary care requirements. As a condition for receiving a grant and grant funds for a domiciliary under this part, the...

  15. 22 CFR 711.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-04-01

    ... accessibility include— (i) Using audio-visual materials and devices to depict those portions of an historic... result in a fundamental alteration in the nature of a program or activity or in undue financial and... agency has the burden of proving that compliance with § 711.150(a) would result in such alteration or...

  16. 22 CFR 530.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-04-01

    ... program accessibility include— (i) Using audio-visual materials and devices to depict those portions of an... action that it can demonstrate would result in a fundamental alteration in the nature of a program or... § 530.150(a) would result in such alteration or burdens. The decision that compliance would result in...

  17. 41 CFR 51-10.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-07-01

    ... audio-visual materials and devices to depict those portions of an historic property that cannot... result in a fundamental alteration in the nature of a program or activity or in undue financial and... agency has the burden of proving that compliance with § 51-10.150(a) would result in such alteration or...

  18. 45 CFR 2104.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... of achieving program accessibility include— (i) Using audio-visual materials and devices to depict...) Require the agency to take any action that it can demonstrate would result in a fundamental alteration in... proving that compliance with § 2104.150(a) would result in such alteration or burdens. The decision that...

  19. 25 CFR 720.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-04-01

    ... of achieving program accessibility include— (i) Using audio-visual materials and devices to depict... action that it can demonstrate would result in a fundamental alteration in the nature of a program or... § 720.150(a) would result in such alteration or burdens. The decision that compliance would result in...

  20. 17 CFR 149.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-04-01

    ... of achieving program accessibility include— (i) Using audio-visual materials and devices to depict...) Require the agency to take any action that it can demonstrate would result in a fundamental alteration in... proving that compliance with § 149.150(a) would result in such alteration or burdens. The decision that...

  1. 45 CFR 1153.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-10-01

    ...), alternative methods of achieving program accessibility include— (i) Using audio-visual materials and devices... action that it can demonstrate would result in a fundamental alteration in the nature of a program or... § 1153.150(a) would result in such alteration or burdens. The decision that compliance would result in...

  2. 34 CFR 1200.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-07-01

    ... accessibility include— (i) Using audio-visual materials and devices to depict those portions of an historic... result in a fundamental alteration in the nature of a program or activity or in undue financial and... agency has the burden of proving that compliance with § 1200.150(a) would result in such alteration or...

  3. 29 CFR 2205.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-07-01

    ... audio-visual materials and devices to depict those portions of an historic property that cannot... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens... has the burden of proving that compliance with § 2205.150(a) would result in such alteration or...

  4. 29 CFR 2706.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-07-01

    ... audio-visual materials and devices to depict those portions of an historic property that cannot... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens... has the burden of proving that compliance with § 2706.150(a) would result in such alteration or...

  5. 45 CFR 2301.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... accessibility include— (i) Using audio-visual materials and devices to depict those portions of an historic... result in a fundamental alteration in the nature of a program or activity or in undue financial and... agency has the burden of proving that compliance with § 2301.150(a) would result in such alteration or...

  6. 5 CFR 2416.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... program accessibility include— (i) Using audio-visual materials and devices to depict those portions of an... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens... has the burden of proving that compliance with § 2416.150(a) would result in such alteration or...

  7. 5 CFR 1636.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... accessibility include— (i) Using audio-visual materials and devices to depict those portions of an historic... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens... has the burden of proving that compliance with § 1636.150(a) would result in such alteration or...

  8. 5 CFR 1207.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... program accessibility include— (i) Using audio-visual materials and devices to depict those portions of an... result in a fundamental alteration in the nature of a program or activity or in undue financial and... agency has the burden of proving that compliance with § 1207.150(a) would result in such alteration or...

  9. 1 CFR 500.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-01-01

    ... of achieving program accessibility include— (i) Using audio-visual materials and devices to depict... action that it can demonstrate would result in a fundamental alteration in the nature of a program or... § 500.150(a) would result in such alteration or burdens. The decision that compliance would result in...

  10. 38 CFR 15.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-07-01

    ...) Using audio-visual materials and devices to depict those portions of an historic property that cannot... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens... has the burden of proving that compliance with § 15.150(a) would result in such alteration or burdens...

  11. 18 CFR 1313.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-04-01

    ... (a)(3), alternative methods of achieving program accessibility include— (i) Using audio-visual...) Require the agency to take any action that it can demonstrate would result in a fundamental alteration in... proving that compliance with § 1313.150(a) would result in such alteration or burdens. The decision that...

  12. 46 CFR 507.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... of achieving program accessibility include— (i) Using audio-visual materials and devices to depict... action that it can demonstrate would result in a fundamental alteration in the nature of a program or... § 507.150(a) would result in such alteration or burdens. The decision that compliance would result in...

  13. 49 CFR 1014.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-10-01

    ... of achieving program accessibility include— (i) Using audio-visual materials and devices to depict... action that it can demonstrate would result in a fundamental alteration in the nature of a program or... § 1014.150(a) would result in such alteration or burdens. The decision that compliance would result in...

  14. 22 CFR 144.150 - Program accessibility: Existing facilities.

    Science.gov (United States)

    2010-04-01

    ... of achieving program accessibility include— (i) Using audio-visual materials and devices to depict... action that it can demonstrate would result in a fundamental alteration in the nature of a program or... § 144.150(a) would result in such alteration or burdens. The decision that compliance would result in...

  15. Self-diffusion coefficients of the trivalent f-element ion series in dilute and moderately dilute aqueous solutions: A comparative study between europium, gadolinium, terbium and berkelium

    Science.gov (United States)

    Rafik, Besbes; Noureddine, Ouerfelli; Abderabbou, Abdelmanef; Habib, Latrous

    2010-03-01

    We have continued the studies on the trivalent ions of the 4f and 5f elements. In this paper, we compare the transport properties (self-diffusion coefficient) of the trivalent aquo ions over two ranges of concentrations (0 — 2×10-3M) and (2×10-3 — 1.5M). Self-diffusion coefficients, D, of the trivalent f-element aquo ion series have been determined in aqueous background electrolytes of Gd(NO3)3 and Nd(ClO4)3, at pH=2.5 (HNO3, HClO4) and at 25°C using the open-end capillary method (O.E.C.M.). This method measures the transportation time of ions across a fixed distance. In this paper, we complete a measurement of self-diffusion coefficient for terbium. We optimized the pH to avoid hydrolysis, ion-pairing and complexation of the trivalent 4f and 5f ions. The variation of D versus √C is not linear for dilute solutions (0 — 2×10-3M) and quasi-linear in moderate concentrations (C<=1.5 M). Similar behavior was observed for Tb, as compared with those for Bk, Eu and Gd. We complete the comparison variation of D/D° versus √C for all studied 4f and 5f elements from concentration 0 to 1.5M and we obtained the same variation with √C for all studied elements. All 4f and 5f elements studied follow the Nernst-Hartley expression.

  16. Terbium-based time-gated Förster resonance energy transfer imaging for evaluating protein-protein interactions on cell membranes.

    Science.gov (United States)

    Lindén, Stina; Singh, Manish Kumar; Wegner, K David; Regairaz, Marie; Dautry, François; Treussart, François; Hildebrandt, Niko

    2015-03-21

    Fluorescence imaging of cells and subcellular compartments is an essential tool to investigate biological processes and to evaluate the development and progression of diseases. In particular, protein-protein interactions can be monitored by Förster resonance energy transfer (FRET) between two proximal fluorophores that are attached to specific recognition biomolecules such as antibodies. We investigated the membrane expression of E- and N-cadherins in three different cell lines used as model systems to study epithelial to mesenchymal transition (EMT) and a possible detection of circulating tumour cells (CTCs). EMT is a key process in cancer metastasis, during which epithelial markers (such as E-cadherin) are down-regulated in the primary tumour whereas mesenchymal markers (such as N-cadherin) are up-regulated, leading to enhanced cell motility, intravasation, and appearance of CTCs. Various FRET donor-acceptor pairs and protein recognition strategies were utilized, in which Lumi4-Tb terbium complexes (Tb) and different organic dyes were conjugated to several distinct E- and N-cadherin-specific antibodies. Pulsed excitation of Tb at low repetition rates (100 Hz) and time-gated (TG) imaging of both the Tb-donor and the dye-acceptor photoluminescence (PL) allowed efficient detection of the EMT markers as well as FRET in the case of sufficient donor-acceptor proximity. Efficient FRET was observed only between two E-cadherin-specific antibodies and further experiments indicated that these antibodies recognized the same E-cadherin molecule, suggesting a limited accessibility of cadherins when they are clustered at adherens junctions. The investigated Tb-to-dye FRET systems provided reduced photobleaching compared to the AlexaFluor 488-568 donor-acceptor pair. Our results demonstrate the applicability and advantages of Tb-based TG FRET for efficient and stable imaging of antibody-antibody interactions on different cell lines. They also reveal the limitations of

  17. A broad G protein-coupled receptor internalization assay that combines SNAP-tag labeling, diffusion-enhanced resonance energy transfer, and a highly emissive terbium cryptate acceptor

    Directory of Open Access Journals (Sweden)

    Angélique eLEVOYE

    2015-11-01

    Full Text Available Although G protein-coupled receptor (GPCR internalization has long been considered a major aspect of the desensitization process that tunes ligand responsiveness, internalization is also involved in receptor resensitization and signaling, as well as the ligand scavenging function of some atypical receptors. Internalization thus contributes to the diversity of GPCR-dependent signaling, and its dynamics and quantification in living cells has generated considerable interest. We developed a robust and sensitive assay to follow and quantify ligand-induced and constitutive GPCR internalization but also receptor recycling in living cells. This assay is based on diffusion-enhanced resonance energy transfer (DERET between cell surface GPCRs labeled with a luminescent terbium cryptate donor and a fluorescein acceptor present in the culture medium. GPCR internalization results in a quantifiable reduction of energy transfer. This method yields a high signal-to-noise ratio due to time-resolved measurements. For various GPCRs belonging to different classes, we demonstrated that constitutive and ligand-induced internalization could be monitored as a function of time and ligand concentration, thus allowing accurate quantitative determination of kinetics of receptor internalization but also half-maximal effective or inhibitory concentrations of compounds. In addition to its selectivity and sensitivity, we provided evidence that DERET-based internalization assay is particularly suitable for characterizing biased ligands. Furthermore, the determination of a Z’-factor value of 0.45 indicates the quality and suitability of DERET-based internalization assay for high-throughput screening (HTS of compounds that may modulate GPCRs internalization.

  18. The innermost regions of the jet in NRAO150

    Directory of Open Access Journals (Sweden)

    Molina Sol N.

    2013-12-01

    Full Text Available NRAO 150 is a very bright millimeter to radio quasar at redshift z=1.52 for which ultra-highresolution VLBI monitoring has revealed a counter-clockwise jet-position-angle wobbling at an angular speed ~11°/yr in the innermost regions of the jet. In this paper we present new total and linearly polarized VLBA images at 43 GHz extending previous studies to cover the evolution of the jet in NRAO 150 between 2006 and early 2009. We propose a new scenario to explain the counter-clockwise rotation of the jet position angle based on a helical motion of the components in a jet viewed faced-on. This alternative scenario is compatible with the interpretation suggested in previous works once the indetermination of the absolute position of the self-calibrated VLBI images is taken into account. Fitting of the jet components motion to a simple internal rotation kinematical model shows that this scenario is a likely alternative explanation for the behavior of the innermost regions in the jet of NRAO 150.

  19. Crystal structure of an eight-coordinate terbium(III ion chelated by N,N′-bis(2-hydroxybenzyl-N,N′-bis(pyridin-2-ylmethylethylenediamine (bbpen2− and nitrate

    Directory of Open Access Journals (Sweden)

    Thaiane Gregório

    2015-01-01

    Full Text Available The reaction of terbium(III nitrate pentahydrate in acetonitrile with N,N′-bis(2-hydroxybenzyl-N,N′-bis(pyridin-2-ylmethylethylenediamine (H2bbpen, previously deprotonated with triethylamine, produced the mononuclear compound [N,N′-bis(2-oxidobenzyl-κO-N,N′-bis(pyridin-2-ylmethyl-κNethylenediamine-κ2N,N′](nitrato-κ2O,O′terbium(III, [Tb(C28H28N4O2(NO3]. The molecule lies on a twofold rotation axis and the TbIII ion is eight-coordinate with a slightly distorted dodecahedral coordination geometry. In the symmetry-unique part of the molecule, the pyridine and benzene rings are both essentially planar and form a dihedral angle of 61.42 (7°. In the molecular structure, the N4O4 coordination environment is defined by the hexadentate bbpen ligand and the bidentate nitrate anion. In the crystal, a weak C—H...O hydrogen bond links molecules into a two-dimensional network parallel to (001.

  20. Kurokawa 150-kW wind turbine generator demonstration; 150 kW Kurokawa furyoku hatsudensho ni tsuite

    Energy Technology Data Exchange (ETDEWEB)

    Okamoto, M.; Shinohara, M.; Sugiyama, T. [Kansai Electric Power Co. Inc., Osaka (Japan)

    1996-10-27

    This paper presents the 150kW wind turbine generator erected at a site near Kurokawa dam lake of Kansai Electric Power Co. in Hyogo prefecture. This generator is composed of a horizontal-axis propeller with 3 blades of 27m in diameter and 36/27rpm, and a tower of 30m high. Harmony with the environment was also considered because of the site in a natural park area. Its demonstration test started in Oct. 1996 at annual mean wind velocity of 2m/s. Soft start was realized by controlling inrush current and preventing voltage drop in system interconnection by use of a thyristor circuit. The dual operation system was adopted of a 30kW small generator at lower wind velocity and a 150kW large one at higher velocity. Two kinds of brakes are used, and rotor revolution was reduced by air brake (blade tip spoiler). Mechanical disk brake works for the stopped rotor or emergency stopping. Even if the wind turbine was stopped by exterior factor, if no anomaly of the turbine is found, it automatically re-starts after removal of the factor. The generator is controlled from a remote control station 150km apart through NTT communication line. 6 figs., 2 tabs.

  1. 46 CFR 150.160 - Carrying a cargo as an exception to the compatibility chart.

    Science.gov (United States)

    2010-10-01

    ... chart. 150.160 Section 150.160 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN... compatibility chart. The Operator of a vessel having on board a cargo carried as an exception under § 150.150 but not listed in Appendix I, Exceptions to the Chart, shall make sure that: (a) The Commandant (G-MSO...

  2. Refined exposure assessment for caramel colours (E 150a, c, d)

    OpenAIRE

    European Food Safety Authority; European Food Safety Authority

    2012-01-01

    This EFSA statement is a refined exposure assessment of caramel colours (E 150a, E 150c and E 150d) taking into account additional information on its use in foods as consumed. The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) adopted a scientific opinion on the re-evaluation of caramel colours (E 150a, E 150b, E 150c, E 150d) used as food additives in 2011. In that opinion, the Panel concluded that the anticipated dietary exposure of child and adult populations may exc...

  3. 150 years constructing the nation through native ingenuity

    Directory of Open Access Journals (Sweden)

    Diego Fernando Hernández Losada

    2012-05-01

    Full Text Available This paper outlines the benefit of public institutions and the results of the Universidad Nacional de Colombia’s School of Engineering’s commitment in contrasting the nation, following 150 years of academic life. This school emerged from the former Polytechnic created on August 24th, 1861,forming part of the Military College, when it received the go-ahead for guiding and organizing engineering studies in Colombia. This institution’s150-year history shows that academic excellence has been honored at the Universidad Nacional de Colombia’s School of Engineering through innovating and creating knowledge in the fields of education, research and services, with the distinguished purpose of improving conditions for and the quality of life of Colombian society. It has encouraged the disadvantaged population by trying to ensure that it can obtain the best options for progress and social mobility at the Universidad Nacional de Colombia, this only being possible through effort, dedication and the knowledge gained in classrooms and laboratories of institutions such as the School of Engineering, transferred to them by teachers having the appropriate technical and human qualities. Engineering in this century faces the challenge of achieving sustainable economic development, so the challenges and opportunities that the School of Engineering will have to face in contributing towards achieving such challenge are also presented in this paper. The School of Engineering must perpetuate its insistence on the principles of academic excellence that have distinguished it during the first 150 years of existence if it is to continue its academic and social leadership, due to government support and the very high human and academic qualities of both its students and professors.

  4. The Next 150 Years of Congenital Adrenal Hyperplasia

    Science.gov (United States)

    Turcu, Adina F.; Auchus, Richard J.

    2015-01-01

    Congenital adrenal hyperplasias (CAH) are a group of autosomal recessive defects in cortisol biosynthesis. Substantial progress has been made since the description of the first report, 150 years ago. This article reviews some of the recent advances in the genetics, diagnosis and treatment of CAH. In addition, we underline the aspects where further progress is required, including, among others, better diagnostic modalities for the mild phenotype and for some of the rare forms of disease, elucidation of epigenetic factors that lead to different phenotypes in patients with identical genotype and expending on treatment options for controlling the adrenal androgen excess. PMID:26047556

  5. Epilepsy research 150 years after Darwin's theory of evolution

    OpenAIRE

    Scorza, Fulvio A.; Vera C. Terra; Carla A. Scorza; Ricardo M. Arida; Cavalheiro, Esper A.

    2009-01-01

    On February 12, 2009, we commemorated the 200th anniversary of Charles Darwin's birth and the 150th anniversary of the publication of the ûrst edition of the "On the origin of species". Only in the sixth edition of the Origin Darwin explicitly stated that natural selection applied to the brain as to all other organs and contemporary epilepsy research plays an interesting role in this scenario. Epilepsy affects approximately 3 percent of the general population and is a complex disease. At leas...

  6. The Double Beta Decay of NEODYMIUM-150 and Molybdenum -100

    Science.gov (United States)

    Nelson, Matthew Alan

    1995-01-01

    The double beta decays of ^{150 }Nd and ^{100}Mo were studied in a Time Projection Chamber (TPC) located at an underground site at Hoover Dam. Studies of 6286.6 h of data obtained from 15.48 g of Nd_2O _3 enriched to 91% in ^{150 }Nd reveal a two-neutrino half-life of T _sp{1/2}{2nu}=(6.27_sp {-.049}{+.049}+/-1.2)times10 ^{18} y at the 90% confidence level, and 90% CL half-life limits for the zero-neutrino and majoron decay channels of T_sp{1/2 }{0nu}>1.10times10^{21 } y, and T_sp{1/2} {0nu,chi}>3.30times10^ {20} y, respectively. Similar studies on 3274.7 h of data from a 16.7 g sample of metallic Mo enriched to 97.4% in ^{100}Mo resulted in measurements of T_sp{1/2 }{2nu}=(6.59_sp{-0.51} {+0.52}+/-1.3)times10^{1 8} {rm y}, T_sp {1/2}{0nu}>1.12times10^ {21} {rm y and} T _sp{1/2}{0nu,chi}>4.07 times10^{20} y, all at the 90% CL.

  7. Reedsport PB150 Deployment and Ocean Test Project

    Energy Technology Data Exchange (ETDEWEB)

    Hart, Phil [Ocean Power Technologies Inc., Pennington, NJ (United States)

    2016-06-03

    As the first utility scale wave power project in the US, the Wave Power Demonstration Project at Reedsport (OR) was planned to consist of 10 PowerBuoys (Phase II)1, located 2.5 miles off the coast. U.S. Department of Energy (DOE) funding under a prior DOE Grant (DE-FG36-08GO88017) along with funding from PNGC Power, an Oregon-based electric power cooperative, was utilized for the design completion, fabrication, assembly and factory testing of the first PowerBuoy for the Reedsport project. The design and fabrication of the first PowerBuoy and factory testing of the power take-off subsystem were completed, and the power take-off subsystem was successfully integrated into the spar at the fabricator’s facility in Oregon. The objectives of this follow-on grant were: advance PB150B design from TRL 5/6 to TRL 7/8; deploy a single PB150 and operate autonomously for 2 years; establish O&M costs; collect environmental information; and establish manufacturing methodologies.

  8. Harleß' Apparatus of Will: 150 years later.

    Science.gov (United States)

    Pfister, Roland; Janczyk, Markus

    2012-09-01

    As the empirical study of action control via ideomotor effect anticipations continues to uncover more and more aspects of this fundamental process, it is time to look back to the 19th century roots of the theory to assess which classical ideas are supported by contemporary research. In turn, classic ideas might stimulate studies on aspects of the ideomotor mechanism that have not yet been addressed empirically. The present article is a tribute to this classical work-more precisely to the article "Der apparat des willens" [The apparatus of will], published by Emil Harleß 150 years ago. At a closer look, Harleß does not only present a concise description of the ideomotor mechanism; he also presents a wealth of intriguing ideas that deserve empirical investigation.

  9. Study of 150 cases of acute appendicitis in children

    Directory of Open Access Journals (Sweden)

    Fallahi Gh

    1998-06-01

    Full Text Available Acute appendicitis is the most common condidition, requiring emergency operation in children. Late appendicitis is still a major sours of morbidity and potential mortality. The charts of all pediatric appendectomy patients (150 cases treated between 1367-1373 (Iranian calender in Amir Kabir Medical Center were reviewed. Mean hospital stay was 4.7 days. Mean ages of patients was 8.5 years. Male to female ratio was 1.2/1. Most common symptom was abdominal pain (100% and deep tenderness in right lower quadrant in 94.6%. Mean temprature was 37.2 and leucocytosis (more than 10000 were in the 76.3%. 14 patients had perforated appendicitis and most common pathology was acut supporative appendicitis. Accuracy of diagnosis was 96.6% and post operative pelvic abccess was 2%. Mortality occurred in one case (0.6%

  10. Microscopic study of superdeformation in the A = 150 mass region

    Energy Technology Data Exchange (ETDEWEB)

    Rigollet, C.; Gall, B. [CNRS, Strasbourg (France); Bonche, P. [CEN Saclay, Gif sur Yvette (France)] [and others

    1996-12-31

    The authors are presently investigating the properties of superdeformed (SD) nuclear states in the A=150 mass region. For that purpose, they use the cranked HFB method in which pairing correlations are treated dynamically by means of the Lipkin-Nogami prescription. Their goal is to take advantage of the large amount of experimental data to test the predictive power of their microscopic approach and of the effective interaction. In the present communication, they focus on {sup 152}Dy and {sup 153}Dy for which there are recent experimental data. In particular lifetime measurements have allowed to extract electric quadrupole moments. The new Skyrme effective force SLy4 is used to describe the nucleon-nucleon interaction, while for the pairing channel the authors use a density-dependent zero-range interaction.

  11. LOFAR 150-MHz observations of SS 433 and W 50

    Science.gov (United States)

    Broderick, J. W.; Fender, R. P.; Miller-Jones, J. C. A.; Trushkin, S. A.; Stewart, A. J.; Anderson, G. E.; Staley, T. D.; Blundell, K. M.; Pietka, M.; Markoff, S.; Rowlinson, A.; Swinbank, J. D.; Horst, A. J. van der; Bell, M. E.; Breton, R. P.; Carbone, D.; Corbel, S.; Eislöffel, J.; Falcke, H.; Grießmeier, J.-M.; Hessels, J. W. T.; Kondratiev, V. I.; Law, C. J.; Molenaar, G. J.; Serylak, M.; Stappers, B. W.; van Leeuwen, J.; Wijers, R. A. M. J.; Wijnands, R.; Wise, M. W.; Zarka, P.

    2018-01-01

    We present LOFAR high-band data over the frequency range 115-189 MHz for the X-ray binary SS 433, obtained in an observing campaign from 2013 February - 2014 May. Our results include a deep, wide-field map, allowing a detailed view of the surrounding supernova remnant W 50 at low radio frequencies, as well as a light curve for SS 433 determined from shorter monitoring runs. The complex morphology of W 50 is in excellent agreement with previously published higher-frequency maps; we find additional evidence for a spectral turnover in the eastern wing, potentially due to foreground free-free absorption. Furthermore, SS 433 is tentatively variable at 150 MHz, with both a debiased modulation index of 11 per cent and a χ2 probability of a flat light curve of 8.2 × 10-3. By comparing the LOFAR flux densities with contemporaneous observations carried out at 4800 MHz with the RATAN-600 telescope, we suggest that an observed ˜0.5-1 Jy rise in the 150-MHz flux density may correspond to sustained flaring activity over a period of approximately six months at 4800 MHz. However, the increase is too large to be explained with a standard synchrotron bubble model. We also detect a wealth of structure along the nearby Galactic plane, including the most complete detection to date of the radio shell of the candidate supernova remnant G 38.7-1.4. This further demonstrates the potential of supernova remnant studies with the current generation of low-frequency radio telescopes.

  12. The rainfall regime in Lisbon in the last 150 years

    Science.gov (United States)

    Kutiel, H.; Trigo, R. M.

    2014-11-01

    The first decades of the rainfall series of Lisbon have been digitized recently allowing a long-term assessment of the rainfall regime for 150 years of uninterrupted, i.e., the first assessment for the longest continuous precipitation time series in western Iberia. This data has been monitored continuously at the D. Luís observatory having started to be published in 1864 in the Observatory's log books (Annals). We use an approach based on different characteristics of rain spells that has been proved to be satisfactory for the analysis of the different parameters related to the rainfall regime in that part of the world. Thus, a rain spell is defined as a series of consecutive days with a measured daily rainfall equal or higher than 1.0 mm. Each rain spell is preceded and followed by at least one dry day. For each rain spell, its duration, its yield (RSY), and its average intensity (RSI) was calculated. Additionally, the total number of rain spells in each year was also considered. Dryness was analyzed using the dry days since last rain approach. Besides the evaluation over the entire 150-year period available, we have also looked into three equally spaced sub-periods. Lisbon reveals large inter-annual and intra-annual variability and both have increased considerably in the last decades. The large intra-annual variability is demonstrated by both; a very large range of annual rainfall percentage accumulated at any given date and by a very large range of dates on which a certain rainfall percentage was accumulated. Again, both metrics increased in the last decades. Parallel to the increase in the uncertainty, a very significant net increase is noticed in the annual totals since the 1960s compared to the first half of the previous century. The increase is mainly due to more intense events which are reflected by higher RSY and RSI values in the last 50 years.

  13. 75 FR 34347 - Airworthiness Directives; Honeywell International Inc. Auxiliary Power Unit Models GTCP36-150(R...

    Science.gov (United States)

    2010-06-17

    ... International Inc. Auxiliary Power Unit Models GTCP36-150(R) and GTCP36-150(RR) AGENCY: Federal Aviation...) for Honeywell International Inc. auxiliary power unit (APU) models GTCP36- 150(R) and GTCP36-150(RR... proposed AD applies to Honeywell International Inc. APU models GTCP36-150(R) and GTCP36-150(RR). We...

  14. Selective Sensing of Fe(3+) and Al(3+) Ions and Detection of 2,4,6-Trinitrophenol by a Water-Stable Terbium-Based Metal-Organic Framework.

    Science.gov (United States)

    Cao, Li-Hui; Shi, Fang; Zhang, Wen-Min; Zang, Shuang-Quan; Mak, Thomas C W

    2015-10-26

    A water-stable luminescent terbium-based metal-organic framework (MOF), {[Tb(L1 )1.5 (H2 O)]⋅3 H2 O}n (Tb-MOF), with rod-shaped secondary building units (SBUs) and honeycomb-type tubular channels has been synthesized and structurally characterized by single-crystal X-ray diffraction. The high green emission intensity and the microporous nature of the Tb-MOF indicate that it can potentially be used as a luminescent sensor. In this work, we show that Tb-MOF can selectively sense Fe(3+) and Al(3+) ions from mixed metal ions in water through different detection mechanisms. In addition, it also exhibits high sensitivity for 2,4,6-trinitrophenol (TNP) in the presence of other nitro aromatic compounds in aqueous solution by luminescence quenching experiments. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Picomolar traces of americium(III) introduce drastic changes in the structural chemistry of terbium(III). A break in the ''gadolinium break''

    Energy Technology Data Exchange (ETDEWEB)

    Welch, Jan M. [TU Wien, Atominstitut, Vienna (Austria); Mueller, Danny; Knoll, Christian; Wilkovitsch, Martin; Weinberger, Peter [TU Wien, Institute of Applied Synthetic Chemistry, Vienna (Austria); Giester, Gerald [University of Vienna, Institute of Mineralogy and Crystallography, Vienna (Austria); Ofner, Johannes; Lendl, Bernhard [TU Wien, Institute of Chemical Technologies and Analytics, Vienna (Austria); Steinhauser, Georg [Leibniz Universitaet Hannover, Institute of Radioecology and Radiation Protection (Germany)

    2017-10-16

    The crystallization of terbium 5,5{sup '}-azobis[1H-tetrazol-1-ide] (ZT) in the presence of trace amounts (ca. 50 Bq, ca. 1.6 pmol) of americium results in 1) the accumulation of the americium tracer in the crystalline solid and 2) a material that adopts a different crystal structure to that formed in the absence of americium. Americium-doped [Tb(Am)(H{sub 2}O){sub 7}ZT]{sub 2} ZT.10 H{sub 2}O is isostructural to light lanthanide (Ce-Gd) 5,5{sup '}-azobis[1H-tetrazol-1-ide] compounds, rather than to the heavy lanthanide (Tb-Lu) 5,5{sup '}-azobis[1H-tetrazol-1-ide] (e.g., [Tb(H{sub 2}O){sub 8}]{sub 2}ZT{sub 3}.6 H{sub 2}O) derivatives. Traces of Am seem to force the Tb compound into a structure normally preferred by the lighter lanthanides, despite a 10{sup 8}-fold Tb excess. The americium-doped material was studied by single-crystal X-ray diffraction, vibrational spectroscopy, radiochemical neutron activation analysis, and scanning electron microscopy. In addition, the inclusion properties of terbium 5,5{sup '}-azobis[1H-tetrazol-1-ide] towards americium were quantified, and a model for the crystallization process is proposed. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  16. 150 keV accelerator as pulsed neutron source; Acelerador de 150 keV como fuente de neutrones pulsada

    Energy Technology Data Exchange (ETDEWEB)

    Cordero, F.

    1970-07-01

    The project of a 150 keV Cockcroft-Walton accelerator built at J.E.N. is described. Beam currents of more than 10 mA, with a neutron intensity of 10{sup 1}1 n.s{sup 1}, are obtained. Also, we report some research made in connection with that project. The role of the contamination in the vacuum system and the performance of the pumps and gauges pumping deuterium gas are studied. Sinusoidal pulses are employed as an analysis method of the discharge in the ion source and the performance of the extracting-focusing system. The parameters of the beam leaving the ion source have been determined; these are used to calculate the electrostatic lenses with the gaussian optics. Measurements concerning deuterium and tritium targets as neutron sources have been made and the processes affecting their practical service life are analyzed. (Author) 71 refs.

  17. Helical tomotherapy. Experiences of the first 150 patients in Heidelberg

    Energy Technology Data Exchange (ETDEWEB)

    Sterzing, F.; Schubert, K.; Sroka-Perez, G.; Kalz, J.; Debus, J.; Herfarth, K. [Dept. of Radiation Oncology, Univ. of Heidelberg (Germany)

    2008-01-15

    Background and purpose: helical tomotherapy was introduced into clinical routine at the Department of Radiation Oncology, University Hospital of Heidelberg, Germany, in July 2006. This report is intended to describe the experience with the first 150 patients treated with helical tomotherapy. Patient selection, time effort, handling of daily image guidance with megavoltage (MV) CT, and quality of radiation plans shall be assessed. Patients and methods: between July 2006 and May 2007, 150 patients were treated with helical tomotherapy in the University Hospital of Heidelberg. Mean age was 60 years with a minimum of 30 years and a maximum of 85 years. 79 of these patients received radiotherapy as a part of multimodal treatment pre- or postoperatively, 17 patients received treatment as a combined radiochemotherapy. 76% were treated with curative intent. Radiotherapy sites were central nervous system (n = 7), head and neck (n = 28), thoracic (n = 37), abdominal (n = 58) and skeletal system (n = 20). Most common tumor entities were prostate cancer (n = 28), breast cancer (n = 17), gastrointestinal tumors (n = 19), pharyngeal carcinoma (n = 14), lymphoma (n = 13), metastatic disease (bone n = 14, liver n = 6, lung n = 4, lymph node n = 2), sarcoma (n = 8), malignant pleural mesothelioma (n = 5), ovarian cancer treated with whole abdominal irradiation (n = 4), lung cancer (n = 3), skin malignancies (n = 3), chordoma (n = 2), meningioma (n = 2), one ependymoma and one medulloblastoma treated with craniospinal axis irradiation (n = 2), and others (n = 4). Nine patients were treated with single-fraction radiosurgery, nine with image-guided spinal reirradiation, and twelve patients were treated at multiple targets simultaneously. A pretreatment MV-CT scan was performed in 98.2% of the 3,026 fractions applied. After matching with the kilovoltage planning CT, corrections for translations and rotation around longitudinal axis (roll) were done. Results: mean time on table was 24

  18. 46 CFR Appendix II to Part 150 - Explanation of Figure 1

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Explanation of Figure 1 II Appendix II to Part 150... COMPATIBILITY OF CARGOES Pt. 150, App. II Appendix II to Part 150—Explanation of Figure 1 Definition of a... referenced by a footnote which indicates that exceptions exist and are listed in Appendix I. Unless the...

  19. 33 CFR 167.150 - Off New York Traffic Separation Scheme: General.

    Science.gov (United States)

    2010-07-01

    ... Scheme: General. 167.150 Section 167.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY OFFSHORE TRAFFIC SEPARATION SCHEMES Description of Traffic Separation Schemes and Precautionary Areas Atlantic East Coast § 167.150 Off New York Traffic...

  20. 33 CFR 150.519 - What are the requirements for emergency lighting and power systems?

    Science.gov (United States)

    2010-07-01

    ... emergency lighting and power systems? 150.519 Section 150.519 Navigation and Navigable Waters COAST GUARD... Specialty Equipment Emergency Lighting and Power Systems § 150.519 What are the requirements for emergency lighting and power systems? (a) The operator must test and inspect the emergency lighting and power systems...

  1. 33 CFR 150.618 - What are the requirements for respiratory protection?

    Science.gov (United States)

    2010-07-01

    ... respiratory protection? 150.618 Section 150.618 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Respiratory Protection § 150.618 What are the requirements for respiratory protection? (a) The deepwater port operator must ensure that respiratory protection measures are taken in compliance with 29 CFR 1910.134...

  2. 24 CFR 943.150 - What procurement standards apply to a PHA's joint venture partner?

    Science.gov (United States)

    2010-04-01

    ... a PHA's joint venture partner? 943.150 Section 943.150 Housing and Urban Development Regulations... HOUSING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT PUBLIC HOUSING AGENCY CONSORTIA AND JOINT VENTURES Subsidiaries, Affiliates, Joint Ventures in Public Housing § 943.150 What procurement standards apply to a PHA...

  3. 45 CFR 150.301 - General rule regarding the imposition of civil money penalties.

    Science.gov (United States)

    2010-10-01

    ... money penalties. 150.301 Section 150.301 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... Enforcement With Respect to Issuers and Non-Federal Governmental Plans-Civil Money Penalties § 150.301 General rule regarding the imposition of civil money penalties. If any health insurance issuer that is subject...

  4. 45 CFR 150.209 - Verification of exhaustion of remedies and contact with State officials.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Verification of exhaustion of remedies and contact with State officials. 150.209 Section 150.209 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 150.209 Verification of exhaustion of remedies and contact with State officials. If CMS receives a...

  5. 33 CFR 150.625 - What must the hazard communication program contain?

    Science.gov (United States)

    2010-07-01

    ... Health Hazard Communication Program § 150.625 What must the hazard communication program contain? (a) Each deepwater port must have a hazard communication program available for the training of, and review... communication program contain? 150.625 Section 150.625 Navigation and Navigable Waters COAST GUARD, DEPARTMENT...

  6. 33 CFR 150.100 - What are the requirements for inspecting deepwater ports?

    Science.gov (United States)

    2010-07-01

    ... inspecting deepwater ports? 150.100 Section 150.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Inspections § 150.100 What are the requirements for inspecting deepwater ports? Under the direction of the Officer in Charge...

  7. 33 CFR 150.305 - How does this subpart apply to unmanned deepwater ports?

    Science.gov (United States)

    2010-07-01

    ... unmanned deepwater ports? 150.305 Section 150.305 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Vessel Navigation § 150.305 How does this subpart apply to unmanned deepwater ports? The master of any tanker calling at an...

  8. 33 CFR 150.812 - What is the purpose of reporting casualties on deepwater ports?

    Science.gov (United States)

    2010-07-01

    ... casualties on deepwater ports? 150.812 Section 150.812 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Reports and Records Reports § 150.812 What is the purpose of reporting casualties on deepwater ports? The Coast Guard, upon...

  9. 21 CFR 163.150 - Sweet cocoa and vegetable fat coating.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Sweet cocoa and vegetable fat coating. 163.150 Section 163.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION CACAO PRODUCTS Requirements for Specific Standardized Cacao Products § 163.150 Sweet cocoa and vegetable fat...

  10. 33 CFR 110.150 - Block Island Sound, N.Y.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Block Island Sound, N.Y. 110.150 Section 110.150 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.150 Block Island Sound, N.Y. (a) The anchorage ground. A 3/4...

  11. 20 CFR 669.150 - How are regulations established for this program?

    Science.gov (United States)

    2010-04-01

    ... program? 669.150 Section 669.150 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF... Definitions § 669.150 How are regulations established for this program? In developing regulations for WIA section 167, we consult with the Migrant and Seasonal Farmworker Employment and Training Advisory...

  12. 21 CFR 1311.150 - Additional requirements for internal application audits.

    Science.gov (United States)

    2010-04-01

    ... audits. 1311.150 Section 1311.150 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE REQUIREMENTS FOR ELECTRONIC ORDERS AND PRESCRIPTIONS (Eff. 6-1-10) Electronic Prescriptions § 1311.150...) Attempted unauthorized access to the electronic prescription application, or successful unauthorized access...

  13. Content analysis of 150 years of British periodicals

    Science.gov (United States)

    Lansdall-Welfare, Thomas; Sudhahar, Saatviga; Thompson, James; Lewis, Justin; Cristianini, Nello

    2017-01-01

    Previous studies have shown that it is possible to detect macroscopic patterns of cultural change over periods of centuries by analyzing large textual time series, specifically digitized books. This method promises to empower scholars with a quantitative and data-driven tool to study culture and society, but its power has been limited by the use of data from books and simple analytics based essentially on word counts. This study addresses these problems by assembling a vast corpus of regional newspapers from the United Kingdom, incorporating very fine-grained geographical and temporal information that is not available for books. The corpus spans 150 years and is formed by millions of articles, representing 14% of all British regional outlets of the period. Simple content analysis of this corpus allowed us to detect specific events, like wars, epidemics, coronations, or conclaves, with high accuracy, whereas the use of more refined techniques from artificial intelligence enabled us to move beyond counting words by detecting references to named entities. These techniques allowed us to observe both a systematic underrepresentation and a steady increase of women in the news during the 20th century and the change of geographic focus for various concepts. We also estimate the dates when electricity overtook steam and trains overtook horses as a means of transportation, both around the year 1900, along with observing other cultural transitions. We believe that these data-driven approaches can complement the traditional method of close reading in detecting trends of continuity and change in historical corpora. PMID:28069962

  14. Content analysis of 150 years of British periodicals.

    Science.gov (United States)

    Lansdall-Welfare, Thomas; Sudhahar, Saatviga; Thompson, James; Lewis, Justin; Cristianini, Nello

    2017-01-24

    Previous studies have shown that it is possible to detect macroscopic patterns of cultural change over periods of centuries by analyzing large textual time series, specifically digitized books. This method promises to empower scholars with a quantitative and data-driven tool to study culture and society, but its power has been limited by the use of data from books and simple analytics based essentially on word counts. This study addresses these problems by assembling a vast corpus of regional newspapers from the United Kingdom, incorporating very fine-grained geographical and temporal information that is not available for books. The corpus spans 150 years and is formed by millions of articles, representing 14% of all British regional outlets of the period. Simple content analysis of this corpus allowed us to detect specific events, like wars, epidemics, coronations, or conclaves, with high accuracy, whereas the use of more refined techniques from artificial intelligence enabled us to move beyond counting words by detecting references to named entities. These techniques allowed us to observe both a systematic underrepresentation and a steady increase of women in the news during the 20th century and the change of geographic focus for various concepts. We also estimate the dates when electricity overtook steam and trains overtook horses as a means of transportation, both around the year 1900, along with observing other cultural transitions. We believe that these data-driven approaches can complement the traditional method of close reading in detecting trends of continuity and change in historical corpora.

  15. Metastatic ovarian tumors: a clinicopathologic study of 150 cases.

    Science.gov (United States)

    Alvarado-Cabrero, Isabel; Rodríguez-Gómez, Adriana; Castelan-Pedraza, Jorge; Valencia-Cedillo, Raquel

    2013-10-01

    To determine the frequency of metastatic ovarian tumors and to identify their clinicopathologic features. A total of 150 patients with pathologically confirmed metastatic ovarian carcinoma who were treated between 1995 and 2011 at the Mexican Oncology Hospital were identified by retrospective review. Clinicopathologic data were analyzed. Metastatic ovarian carcinoma accounted for 15.7% of all ovarian malignancies. The primary sites of nongynecologic tumors were the colon (30%), stomach (16%), appendix (13%), breast (13%), pancreas (12%), biliary tract (15%), and liver (4%). Gynecologic primary sites were the uterine cervix (4%) and the uterine body (23%). Primary malignancies were detected first in 66 patients (44%) and simultaneously with ovarian metastasis in 53 patients (35.3%). An ovarian mass was the first manifestation of disease in 20.6% of the cases. The patients ranged in age from 26 to 72 years (mean, 51). Krukenberg tumors were found in 35 patients (23%). The cut surfaces of the ovaries were solid in 68 patients, solid-cystic in 38, and multicystic in 44. Metastatic ovarian carcinomas are an important group of ovarian neoplasms, constituting 15.7% of all ovarian malignancies. Most of them arise from the gastrointestinal tract.

  16. Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.

    Directory of Open Access Journals (Sweden)

    Olga Romanets-Korbut

    Full Text Available CD150 (IPO3/SLAM belongs to the SLAM family of receptors and serves as a major entry receptor for measles virus. CD150 is expressed on normal and malignant cells of the immune system. However, little is known about its expression outside the hematopoietic system, especially tumors of the central nervous system (CNS. Although CD150 was not found in different regions of normal brain tissues, our immunohistochemical study revealed its expression in 77.6% of human CNS tumors, including glioblastoma, anaplastic astrocytoma, diffuse astrocytoma, ependymoma, and others. CD150 was detected in the cytoplasm, but not on the cell surface of glioma cell lines, and it was colocalized with the endoplasmic reticulum and Golgi complex markers. In addition to the full length mRNA of the mCD150 splice isoform, in glioma cells we found a highly expressed novel CD150 transcript (nCD150, containing an 83 bp insert. The insert is derived from a previously unrecognized exon designated Cyt-new, which is located 510 bp downstream of the transmembrane region exon, and is a specific feature of primate SLAMF1. Both mCD150 and nCD150 cDNA variants did not contain any mutations and had the leader sequence. The nCD150 transcript was also detected in normal and malignant B lymphocytes, primary T cells, dendritic cells and macrophages; however, in glioma cells nCD150 was found to be the predominant CD150 isoform. Similarly to mCD150, cell surface expression of nCD150 allows wild type measles virus entry to the cell. Our data indicate that CD150 expression in CNS tumors can be considered a new diagnostic marker and potential target for novel therapeutic approaches.

  17. Learning-style profiles of 150 veterinary medical students.

    Science.gov (United States)

    Neel, Jennifer A; Grindem, Carol B

    2010-01-01

    Awareness of student learning-style preferences is important for several reasons. Understanding differences in learning styles permits instructors to design course materials that allow all types of learners to absorb and process information. Students who know their own learning style are better able to help themselves in courses taught in a non-preferred method by developing study strategies in line with their preferred learning method. We used the Felder and Solomon Index of Learning Styles to assess the learning-style profiles of 150 veterinary students in three consecutive years. Students were predominantly active (56.7%), sensing (79.3%), visual (76.7%), and sequential (69.3%). Most were balanced on the active-reflective (59.3%) and global-sequential (50%) dimensions, and 61.3% and 54% were moderately to strongly sensing and visual, respectively. Small but significant numbers of students were moderately to strongly intuitive (8.7%), verbal (13%), and global (12%). The most common patterns were active-sensing-visual-sequential (26%), reflective-sensing-visual-sequential (19.3%), active-sensing-visual-global (8.7%), and active-sensing-verbal-sequential (8.7%). Although most students (65.3%) were balanced on one to two dimensions, 77.3% had one or more strong preferences. Our results show that although people have dominant learning-style preference and patterns, they have significant minor preferences and patterns across all dimensions with moderate to strong preferences on each scale. These results indicate that a balanced approach to teaching is essential to allow all students to learn optimally.

  18. [Anaerobic bacteria 150 years after their discovery by Pasteur].

    Science.gov (United States)

    García-Sánchez, José Elías; García-Sánchez, Enrique; Martín-Del-Rey, Ángel; García-Merino, Enrique

    2015-02-01

    In 2011 we celebrated the 150th anniversary of the discovery of anaerobic bacteria by Louis Pasteur. The interest of the biomedical community on such bacteria is still maintained, and is particularly focused on Clostridium difficile. In the past few years important advances in taxonomy have been made due to the genetic, technological and computing developments. Thus, a significant number of new species related to human infections have been characterised, and some already known have been reclassified. At pathogenic level some specimens of anaerobic microflora, that had not been isolated from human infections, have been now isolated in some clinical conditions. There was emergence (or re-emergence) of some species and clinical conditions. Certain anaerobic bacteria have been associated with established infectious syndromes. The virulence of certain strains has increased, and some hypotheses on their participation in certain diseases have been given. In terms of diagnosis, the routine use of MALDI-TOF has led to a shortening of time and a cost reduction in the identification, with an improvement directly related to the improvement of data bases. The application of real-time PCR has been another major progress, and the sequencing of 16srRNA gene and others is currently a reality for several laboratories. Anaerobes have increased their resistance to antimicrobial agents, and the emergence of resistance to carbapenems and metronidazole, and multi-resistance is a current reality. In this situation, linezolid could be an effective alternative for Bacteroides. Fidaxomicin is the only anti-anaerobic agent introduced in the recent years, specifically for the diarrhoea caused by C.difficile. Moreover, some mathematical models have also been proposed in relation with this species. Copyright © 2013 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

  19. Acute Drug Poisoning in Tunisian Children: About 150 Cases

    Directory of Open Access Journals (Sweden)

    Hager Barakizou

    2016-04-01

    Full Text Available Background: Acute drug poisoning remains an important public health problem and represents the second most frequent accidental disease in children. In this study, we identified epidemiological and clinical features of children admitted for acute drug poisoning and related factors associated with suicidal poisoning. Methods: We conducted a retrospective study in the Department of Pediatrics, the Military Hospital, Tunis, over a period of 8 years (2008-2014. Children aged less than 16 yr and admitted for acute drug poisoning were included. Cases of drug addiction were excluded. Two groups were compared: accidental poisoning / suicidal poisoning. Results: We collected 150 cases. The ratio male / female was 1:1.2. The mean age was 4.3 yr. Poisoning was due to one drug in 82% of cases. Children were asymptomatic in 39% of cases, had digestive and neurologic symptoms respectively in 30% and 20% of cases, respectively. Psychotropics came in the first place (20% followed by paracetamol (16%. Two groups were identified: accidental poisoning (74 % and suicidal poisoning (26%. Four factors were significantly associated with suicidal poisoning: age ≥ 8 yr (P< 0.001, OR= 16.25, 95% IC : [6.44-40.95], female gender (P=0.011, OR= 5.4, 95% IC: [2.09-13.91], multiple drug intake (P < 0.001, OR= 9.42, 95% IC: [3.05-29.03] and use of psychotropics (P= 0.003, OR=4.81, 95%IC: [2.06-11.26] . Conclusion: Two groups had to be distinguished: accidental and suicidal drug poisoning. The identification of their characteristics and their predisposing factors is necessary in order to take appropriate preventive actions.

  20. Sodium terbium(III polyphosphate

    Directory of Open Access Journals (Sweden)

    Abdelghani Oudahmane

    2010-04-01

    Full Text Available Single crystals of the title compound, NaTb(PO34, were obtained by solid-state reaction. This compound belongs to type II of long-chain polyphosphates with the general formula AIBIII(PO34. It is isotypic with the NaNd(PO34 and NaEr(PO34 homologues. The crystal structure is built up of infinite crenelated chains of corner-sharing PO4 tetrahedra with a repeating unit of four tetrahedra. These chains, extending parallel to [100], are linked by isolated TbO8 square antiprisms, forming a three-dimensional framework. The Na+ ions are located in channels running along [010] and are surrounded by six oxygen atoms in a distorted octahedral environment within a cut-off distance <2.9 Å.

  1. [Changes in cortikosteron concentration--a marker of stress-response under the influence of terahertz radiations at nitrogen oxide frequencies of 150, 176-150, 664 GHz].

    Science.gov (United States)

    Kirichuk, V F; Tsymbal, A A; Antipova, O N; Krenitskiĭ, A P; Maĭborodin, A V

    2008-11-01

    Influence of electromagnetic radiation ofterahertz frequencies of molecular spectrum of radiation and absorption oxide nitrogen of 150, 176-150, 664 GHz by means of device KVCH-NO forming specified spectra, on concentration at stress-realizing hormone cortikosteron in conditions of sharp and chronic stress was is studied. It is shown that preliminary continuous 15-minute influence by electromagnetic radiation of terahertz range at frequencies of oxide nitrogen 150, 176-150, 664 GHz limits development of stress-reaction due to reduction of allocation by a of adrenal glands of glucocorticoids, in particular cortikosteron, that led restriction of excessive activation of stress-realizing system. The given fact serves as the proof of stress-limiting function of electromagnetic radiation at the given range.

  2. AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin

    Directory of Open Access Journals (Sweden)

    Shapiro Mark S

    2011-05-01

    Full Text Available Abstract Background The transient receptor potential vanilloid type1 (TRPV1 is expressed in nociceptive sensory neurons and is sensitive to phosphorylation. A-Kinase Anchoring Protein 79/150 (AKAP150 mediates phosphorylation of TRPV1 by Protein Kinases A and C, modulating channel activity. However, few studies have focused on the regulatory mechanisms that control AKAP150 association with TRPV1. In the present study, we identify a role for calcium/calmodulin in controlling AKAP150 association with, and sensitization of, TRPV1. Results In trigeminal neurons, intracellular accumulation of calcium reduced AKAP150 association with TRPV1 in a manner sensitive to calmodulin antagonism. This was also observed in transfected Chinese hamster ovary (CHO cells, providing a model for conducting molecular analysis of the association. In CHO cells, the deletion of the C-terminal calmodulin-binding site of TRPV1 resulted in greater association with AKAP150, and increased channel activity. Furthermore, the co-expression of wild-type calmodulin in CHOs significantly reduced TRPV1 association with AKAP150, as evidenced by total internal reflective fluorescence-fluorescence resonance energy transfer (TIRF-FRET analysis and electrophysiology. Finally, dominant-negative calmodulin co-expression increased TRPV1 association with AKAP150 and increased basal and PKA-sensitized channel activity. Conclusions the results from these studies indicate that calcium/calmodulin interferes with the association of AKAP150 with TRPV1, potentially extending resensitization of the channel.

  3. Prognostic role of microRNA-150 in various carcinomas: a meta-analysis

    Directory of Open Access Journals (Sweden)

    Wang W

    2016-03-01

    Full Text Available Wei Wang, Xinshuai Wang, Yali Zhang, Dan Wang, Hui Gao, Lijuan Wang, Shegan Gao Henan Key Laboratory of Cancer Epigenetics, Cancer Institute, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, People’s Republic of China Objective: MicroRNA-150 (miR-150 was revealed to be an attractive prognostic biomarker in recent studies. However, the prognostic significance of miR-150 expression in cancer remains inconclusive. The aim of this study was to summarize the global predicting role of miR-150 in survival in patients with various carcinomas.Methods: Eligible studies were identified through multiple search strategies. Data were extracted from the studies by investigating the relationship between miR-150 expression and survival in patients with cancer. A meta-analysis of the hazard ratio (HR was then performed to evaluate the prognostic role of miR-150 in different tumors. Pooled HRs of miR-150 for overall survival and progression-free survival were calculated to measure the effect of miR-150 expression on prognosis.Results: This meta-analysis included nine published studies concerning various carcinomas. Our results indicate that an elevated miR-150 expression is associated with an enhanced overall survival in the digestive tract cancer subgroup (HR =0.57, 95% confidence interval [CI]: 0.37–0.90 and a poor progression-free survival in various cancers (HR =3.08, 95% CI: 2.00–4.75.Conclusion: miR-150 may have the potential to become a new useful prognostic factor to monitor cancer prognosis and progression. However, given the current insufficient relevant data, further clinical studies are needed. Keywords: microRNA-150, carcinomas, prognosis, meta-analysis

  4. 9 CFR 592.150 - When an application may be rejected.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false When an application may be rejected. 592.150 Section 592.150 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... holding office or a responsible position with or having a substantial financial interest or share in the...

  5. 19 CFR 12.150 - Merchandise prohibited by economic sanctions; detention; seizure or other disposition; blocked...

    Science.gov (United States)

    2010-04-01

    ...; detention; seizure or other disposition; blocked property. 12.150 Section 12.150 Customs Duties U.S. CUSTOMS...; detention; seizure or other disposition; blocked property. (a) Generally. Merchandise from certain countries... the United States shall be detained until the question of its release, seizure, or other disposition...

  6. 12 CFR 563b.150 - What must I include in my application for conversion?

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false What must I include in my application for conversion? 563b.150 Section 563b.150 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE... legal opinion indicating that any marketing materials comply with all applicable securities laws. (4) An...

  7. 24 CFR 1720.150 - Failure to comply with administrative law judge's directions.

    Science.gov (United States)

    2010-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Failure to comply with administrative law judge's directions. 1720.150 Section 1720.150 Housing and Urban Development Regulations...

  8. 21 CFR 172.150 - 4-Hydroxymethyl-2,6-di-tert-butylphenol.

    Science.gov (United States)

    2010-04-01

    ... the food, including the essential (volatile) oil content of the food. ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true 4-Hydroxymethyl-2,6-di-tert-butylphenol. 172.150 Section 172.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  9. 32 CFR 150.14 - Waiver or withdrawal of appellate review.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Waiver or withdrawal of appellate review. 150.14... PERTAINING TO MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.14 Waiver or withdrawal of appellate review. Withdrawals from appellate review, and waivers of appellate review filed...

  10. miR-150 blocks MLL-AF9-associated leukemia through oncogene repression.

    Science.gov (United States)

    Bousquet, Marina; Zhuang, Guoqing; Meng, Cong; Ying, Wei; Cheruku, Patali S; Shie, Andrew T; Wang, Stephanie; Ge, Guangtao; Wong, Piu; Wang, Gang; Safe, Stephen; Zhou, Beiyan

    2013-08-01

    The microRNA miR-150, a critical regulator of hematopoiesis, is downregulated in mixed-lineage leukemia (MLL). In this study, miR-150 acts as a potent leukemic tumor suppressor by blocking the oncogenic properties of leukemic cells. By using MLL-AF9-transformed cells, we demonstrate that ectopic expression of miR-150 inhibits blast colony formation, cell growth, and increases apoptosis in vitro. More importantly, ectopic expression of miR-150 in MLL-AF9-transformed cells completely blocked the development of myeloid leukemia in transplanted mice. Furthermore, gene expression profiling revealed that miR-150 altered the expression levels of more than 30 "stem cell signature" genes and many others that are involved in critical cancer pathways. In addition to the known miR-150 target Myb, we also identified Cbl and Egr2 as bona fide targets and shRNA-mediated suppression of these genes recapitulated the pro-apoptotic effects observed in leukemic cells with miR-150 ectopic expression. In conclusion, we demonstrate that miR-150 is a potent leukemic tumor suppressor that regulates multiple oncogenes. These data establish new, key players for the development of therapeutic strategies to treat MLL-AF9-related leukemia. ©2013 AACR.

  11. 10 CFR 150.19 - Submission to Commission of tritium reports.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Submission to Commission of tritium reports. 150.19... Agreement States § 150.19 Submission to Commission of tritium reports. (a)-(b) (c) Except as specified in... possess tritium shall report promptly to the appropriate NRC Regional Office as shown in appendix D of...

  12. 21 CFR 801.150 - Medical devices; processing, labeling, or repacking.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Medical devices; processing, labeling, or repacking. 801.150 Section 801.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... commerce to another establishment or to a contract sterilizer for sterilization, the Food and Drug...

  13. 20 CFR 1001.150 - Method of calculating State basic grant awards.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Method of calculating State basic grant awards. 1001.150 Section 1001.150 Employees' Benefits OFFICE OF THE ASSISTANT SECRETARY FOR VETERANS' EMPLOYMENT AND TRAINING SERVICE, DEPARTMENT OF LABOR SERVICES FOR VETERANS Formula for the Allocation of...

  14. 7 CFR 929.150 - Transfer or assignment of sales history.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Transfer or assignment of sales history. 929.150 Section 929.150 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE...

  15. 41 CFR 102-38.150 - How long is the inspection period?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How long is the inspection period? 102-38.150 Section 102-38.150 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 38-SALE OF PERSONAL...

  16. 21 CFR 150.161 - Artificially sweetened fruit preserves and jams.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Artificially sweetened fruit preserves and jams. 150.161 Section 150.161 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN..., spice extract. (2) A vinegar, lemon juice, lime juice, citric acid, lactic acid, malic acid, tartaric...

  17. 33 CFR 150.210 - What are the restrictions on serving in more than one position?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What are the restrictions on serving in more than one position? 150.210 Section 150.210 Navigation and Navigable Waters COAST GUARD... What are the restrictions on serving in more than one position? No person may serve in more than one of...

  18. 33 CFR 150.435 - When are cargo transfers not allowed?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false When are cargo transfers not allowed? 150.435 Section 150.435 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... or serving the port. ...

  19. 40 CFR 417.150 - Applicability; description of the manufacture of spray dried detergents subcategory.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Applicability; description of the manufacture of spray dried detergents subcategory. 417.150 Section 417.150 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS SOAP AND DETERGENT MANUFACTURING...

  20. Femoral haemostasis with Vasoseal ES: experience in 150 patients; Emostasi femorale mediante Vasoseal ES: esperienza in 150 pazienti

    Energy Technology Data Exchange (ETDEWEB)

    Gazzera, Carlo; Doriguzzi Breatta, Andrea; Veltri, Andrea; Righi, Dorico; Barbero, Stefano; Balderi, Alberto; Petracchni, Massimo; Gandini, Giovanni [Ospedale San Giovanni Battista, Torino (Italy); Torino Univ., Torino (Italy). Istituto di Radiologia

    2005-02-01

    Purpose: The aim of this study is to assess the effectiveness and safety of the use of Vasoseal ES collagen plug in heavenly anti coagulated patients with risk of complications at the vascular access site who had undergone vascular radiological intervention. Materials and methods: Between January 2002 and March 2003 180 consecutive transfemoral arterial accesses in 169 patients subjected to vascular radiological procedures were performed (bilateral access was performed in 11 patients): 140 percutaneous transluminal angioplasties and 40 transarterial chemoembolisations. All the patients who underwent angioplasty were given 3,000 IU of sodic heparin intravenously during the procedure and later a prolonged antiaggregant therapy was undertaken (ticlopidine 500 mg/day and aspirin 150 mg/day). The sheaths were removed at the end of the surgical manoeuvre and two cartridges of collagen were positioned on the external surface of the artery. The mean values of platelets and partial thromboplastin time were 42,000/ml and 170 s, respectively, in cirrhotic patients against 250,000/ml and 200 s in patients with peripheral arteriopathy. The next day a colour Doppler examination was performed at the puncture site. Results: The technique proved successful in 89.4% of cases (161/180). In 19/180 vascular accesses placement of the haemostatic cartridges was not possible owing to the inability to compress the common femoral artery proximal to the release site (4/19), owing to a pre-existing haematoma (5/19) and owing to the limited presence of subcutoma (5/19) and owing to the limited presence of subcutaneous tissue (10/19). The mean time required for the placement of Vasoseal ES was 4 min. The mean time to haemostasis was 6 min. The mean time to mobilisation was 4 hr. Only in two patients was there an onset of a pseudoaneurysm of the right common femoral artery-, the lesions were treated with ultrasonography-guided compression. In addition, 16 small local haematomas were recorded. In

  1. microRNA-150 inhibits the formation of macrophage foam cells through targeting adiponectin receptor 2

    Energy Technology Data Exchange (ETDEWEB)

    Li, Jing [Department of Geratory, Linzi District People’s Hospital of Zibo City, Zibo, Shandong (China); Zhang, Suhua, E-mail: drsuhuangzhang@qq.com [Department of HealthCare, Qilu Hospital of Shandong University (Qingdao), Qingdao City, Qingdao (China)

    2016-08-05

    Transformation of macrophages into foam cells plays a critical role in the pathogenesis of atherosclerosis. The aim of this study was to determine the expression and biological roles of microRNA (miR)-150 in the formation of macrophage foam cells and to identify its functional target(s). Exposure to 50 μg/ml oxidized low-density lipoprotein (oxLDL) led to a significant upregulation of miR-150 in THP-1 macrophages. Overexpression of miR-150 inhibited oxLDL-induced lipid accumulation in THP-1 macrophages, while knockdown of miR-150 enhanced lipid accumulation. apoA-I- and HDL-mediated cholesterol efflux was increased by 66% and 43%, respectively, in miR-150-overexpressing macrophages relative to control cells. In contrast, downregulation of miR-150 significantly reduced cholesterol efflux from oxLDL-laden macrophages. Bioinformatic analysis and luciferase reporter assay revealed adiponectin receptor 2 (AdipoR2) as a direct target of miR-150. Small interfering RNA-mediated downregulation of AdipoR2 phenocopied the effects of miR-150 overexpression, reducing lipid accumulation and facilitating cholesterol efflux in oxLDL-treated THP-1 macrophages. Knockdown of AdipoR2 induced the expression of proliferator-activated receptor gamma (PPARγ), liver X receptor alpha (LXRα), ABCA1, and ABCG1. Moreover, pharmacological inhibition of PPARγ or LXRα impaired AdipoR2 silencing-induced upregulation of ABCA1 and ABCG1. Taken together, our results indicate that miR-150 can attenuate oxLDL-induced lipid accumulation in macrophages via promotion of cholesterol efflux. The suppressive effects of miR-150 on macrophage foam cell formation are mediated through targeting of AdipoR2. Delivery of miR-150 may represent a potential approach to prevent macrophage foam cell formation in atherosclerosis. -- Highlights: •miR-150 inhibits macrophage foam cell formation. •miR-150 accelerates cholesterol efflux from oxLDL-laden macrophages. •miR-150 suppresses macrophage foam cell

  2. Dynactin subunit p150(Glued is a neuron-specific anti-catastrophe factor.

    Directory of Open Access Journals (Sweden)

    Jacob E Lazarus

    2013-07-01

    Full Text Available Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease. The microtubule motor cytoplasmic dynein and its partner complex dynactin drive retrograde transport from the distal axon. We have recently shown that the p150(Glued subunit of dynactin promotes the initiation of dynein-driven cargo motility from the microtubule plus-end. Because plus end-localized microtubule-associated proteins like p150(Glued may also modulate the dynamics of microtubules, we hypothesized that p150(Glued might promote cargo initiation by stabilizing the microtubule track. Here, we demonstrate in vitro using assembly assays and TIRF microscopy, and in primary neurons using live-cell imaging, that p150(Glued is a potent anti-catastrophe factor for microtubules. p150(Glued alters microtubule dynamics by binding both to microtubules and to tubulin dimers; both the N-terminal CAP-Gly and basic domains of p150(Glued are required in tandem for this activity. p150(Glued is alternatively spliced in vivo, with the full-length isoform including these two domains expressed primarily in neurons. Accordingly, we find that RNAi of p150(Glued in nonpolarized cells does not alter microtubule dynamics, while depletion of p150(Glued in neurons leads to a dramatic increase in microtubule catastrophe. Strikingly, a mutation in p150(Glued causal for the lethal neurodegenerative disorder Perry syndrome abrogates this anti-catastrophe activity. Thus, we find that dynactin has multiple functions in neurons, both activating dynein-mediated retrograde axonal transport and enhancing microtubule stability through a novel anti-catastrophe mechanism regulated by tissue-specific isoform expression; disruption of either or both of these functions may contribute to neurodegenerative disease.

  3. Hydration kinetics and 10-km outdoor running performance following 75% versus 150% between bout fluid replacement.

    Science.gov (United States)

    Davis, Brett Alan; Thigpen, Lauren Kellet; Hornsby, Jared Heath; Green, James Matthew; Coates, Thomas Elliot; O'Neal, Eric Kyle

    2014-01-01

    Current American College of Sports Medicine (ACSM) guidelines recommend replacing 150% of sweat losses between training bouts separated by ≤12 hours, but little evidence exists concerning the implications of this strategy for runners. Participants (n = 13) in this study replaced 75% (1637 ± 372 mL) or 150% (3099 ± 850 mL) of sweat losses following an outdoor evening run (∼75 minutes; Wet-bulb-globe temperature (WBGT) = ∼27°C) and consumed a standardised evening meal and breakfast before completing an outdoor (WBGT = ∼23°C) 10-km time-trial the following morning. Urine was collected between runs and urine specific gravity (USG) was assessed pre-run. Significant differences were found in pre-run body mass (75% = 69.6 ± 9.2; 150% = 70.1 ± 9.3 kg; P = 0.02) and USG (75% = 1.026 ± 0.005; 150% = 1.014 ± 0.007; P < 0.001). Heart rate during 10-km run (168 ± 14 versus 168 ± 12 beats min(-1)) and post-run intestinal temperature (39.08 ± 0.52 versus 39.00 ± 0.70 °C) did not differ for 75% and 150%, respectively, despite an ∼3% performance improvement (75% = 47.28 ± 6.64; 150% = 45.93 ± 6.04 minutes; P = 0.001) due to a faster pace in the second half of the run with 150% replacement. Session rate of perceived exertion (RPE) was lower (P = 0.02) during 150% (7.5 ± 1.3) versus 75% (8.4 ± 0.9). Reluctant drinkers potentially hinder training quality between evening and morning runs in the heat, but copious urine production and difficulty in consuming recommended fluid volumes suggest fluid replacement <150% may be more ideal.

  4. Kaitseliit kogus Raivo Samelselja kodu taastamiseks 150 000 krooni / Külli Koppelmaa

    Index Scriptorium Estoniae

    Koppelmaa, Külli, 1970-

    2003-01-01

    Kaitseliidu Harju maleva esindajatekogul andis Kaitseliidu ülem major Benno Leesik kurjategijate käe läbi koduta jäänud Kuusalu malevkonna pealikule Raivo Samelseljale üle tsheki 150 000 krooniga

  5. Carter : Iisraelil on 150 või enam tuumapommi / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2008-01-01

    USA endine president Jimmy Carter väitis, et Iisraelil on 150 tuumapommi või rohkemgi. Eri hinnangutest Iisraeli tuumapommide arvu kohta, n.-ö. tunnustatud tuumariigid maailmas. Lisa: Tuumakatsetus 1979. aastal?

  6. Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancer

    DEFF Research Database (Denmark)

    McLeod, David G; Iversen, Peter; See, William A

    2006-01-01

    To evaluate, in the ongoing Early Prostate Cancer (EPC) trial programme, the efficacy and tolerability of bicalutamide 150 mg once daily in addition to standard care for localized or locally advanced, nonmetastatic prostate cancer....

  7. 32 CFR 150.20 - Petitions for extraordinary relief, answer, and reply.

    Science.gov (United States)

    2010-07-01

    ... REGULATIONS PERTAINING TO MILITARY JUSTICE COURTS OF CRIMINAL APPEALS RULES OF PRACTICE AND PROCEDURE § 150.20... be obtained during the ordinary course of appellate review; (8) If desired, a request for appointment...

  8. 29 CFR 780.150 - Scope and limits of “preparation for market.”

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Scope and limits of âpreparation for market.â 780.150... STANDARDS ACT General Scope of Agriculture Preparation for Market § 780.150 Scope and limits of “preparation for market.” “Preparation for market” is also named as one of the practices which may be included in...

  9. Bicalutamide 150 mg plus standard care vs standard care alone for early prostate cancer

    DEFF Research Database (Denmark)

    McLeod, David G; Iversen, Peter; See, William A

    2006-01-01

    To evaluate, in the ongoing Early Prostate Cancer (EPC) trial programme, the efficacy and tolerability of bicalutamide 150 mg once daily in addition to standard care for localized or locally advanced, nonmetastatic prostate cancer.......To evaluate, in the ongoing Early Prostate Cancer (EPC) trial programme, the efficacy and tolerability of bicalutamide 150 mg once daily in addition to standard care for localized or locally advanced, nonmetastatic prostate cancer....

  10. Statistics of 150-km echoes over Jicamarca based on low-power VHF observations

    Directory of Open Access Journals (Sweden)

    J. L. Chau

    2006-07-01

    Full Text Available In this work we summarize the statistics of the so-called 150-km echoes obtained with a low-power VHF radar operation at the Jicamarca Radio Observatory (11.97 S, 76.87 W, and 1.3 dip angle at 150-km altitude in Peru. Our results are based on almost four years of observations between August 2001 and July 2005 (approximately 150 days per year. The majority of the observations have been conducted between 08:00 and 17:00 LT. We present the statistics of occurrence of the echoes for each of the four seasons as a function of time of day and altitude. The occurrence frequency of the echoes is ~75% around noon and start decreasing after 15:00 LT and disappear after 17:00 LT in all seasons. As shown in previous campaign observations, the 150-echoes appear at a higher altitude (>150 km in narrow layers in the morning, reaching lower altitudes (~135 km around noon, and disappear at higher altitudes (>150 km after 17:00 LT. We show that although 150-km echoes are observed all year long, they exhibit a clear seasonal variability on altitudinal coverage and the percentage of occurrence around noon and early in the morning. We also show that there is a strong day-to-day variability, and no correlation with magnetic activity. Although our results do not solve the 150-km riddle, they should be taken into account when a reasonable theory is proposed.

  11. Deep GMRT 150 MHz Observations of the DEEP2 Fields: Searching ...

    Indian Academy of Sciences (India)

    sources as a function of flux density at GMRT 150 MHz (right). 2. Result and discussion. One of the deep fields, centered on 2330+0000, from DEEP2 was analysed using. AIPS++ (Sirothia et al. 2009), and the final image obtained has an rms noise. ∼1 mJy/beam with a resolution of 20 . The 150 MHz source catalog of this ...

  12. Post-void residual urine under 150 ml does not exclude voiding dysfunction in women

    DEFF Research Database (Denmark)

    Khayyami, Yasmine; Klarskov, Niels; Lose, Gunnar

    2016-01-01

    INTRODUCTION AND HYPOTHESIS: It has been claimed that post-void residual urine (PVR) below 150 ml rules out voiding dysfunction in women with stress urinary incontinence (SUI) and provides license to perform sling surgery. The cut-off of 150 ml seems arbitrary, not evidence-based, and so we sought....... CONCLUSIONS: Patients with voiding dysfunction often have normal PVR and so PVR incontinence surgery....

  13. Page | 150

    African Journals Online (AJOL)

    Fr. Ikenga

    the patient, especially an adult and competent one, reserves the right to refuse medical treatment even though that .... 6 G.J. Annas, es alia, “The Right to Refuse Treatment: A Model Act”, 73 American Journal of Public Health, Vol. ... Superior Court (Glenchur),14 which extended the concept of medical treatment to include.

  14. A europium- and terbium-coated magnetic nanocomposite as sorbent in dispersive solid phase extraction coupled with ultra-high performance liquid chromatography for antibiotic determination in meat samples.

    Science.gov (United States)

    Castillo-García, M L; Aguilar-Caballos, M P; Gómez-Hens, A

    2015-12-18

    A new magnetic dispersive solid-phase extraction approach based on Eu- and Tb-coated magnetic nanocomposites, combined with ultra-high performance liquid chromatography with fluorometric detection, is reported for the extraction and simultaneous determination of veterinary antibiotics. The method is aimed at monitoring of potential residues of three tetracyclines, namely oxytetracycline, tetracycline, chlortetracycline and three acidic quinolones, such as oxolinic acid, nalidixic acid and flumequine, chosen as model analytes, in animal muscle samples. The nanocomposites were obtained by synthesizing magnetic nanoparticles by a co-precipitation method and their coating with terbium and europium ions. The limits of detection obtained using standard solutions were: 1.0, 1.5, 3.8, 0.25, 0.7 and 1.2ngmL(-1), which corresponds to 3.3, 5.0, 12.7, 0.8, 2.3 and 4.0μgkg(-1) for oxytetracycline, tetracycline, chlortetracycline, oxolinic acid, nalidixic acid and flumequine, respectively, in meat samples. The precision values, obtained in the presence of the sample matrix, were in the ranges 0.12-2.0% and 2.6-15.4% for retention times and areas, respectively. The selectivity of the method was checked by assaying different veterinary drugs, finding that most of them did not interfere at the same concentration levels as that of analytes. A recovery study was performed in the presence of chicken and pork muscle samples, which provided values in the range of 61.5-102.6%. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Correlations of Behavioral Deficits with Brain Pathology Assessed through Longitudinal MRI and Histopathology in the HdhQ150/Q150 Mouse Model of Huntington's Disease.

    Directory of Open Access Journals (Sweden)

    Ivan Rattray

    Full Text Available A variety of mouse models have been developed that express mutant huntingtin (mHTT leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor activity, grip strength by 36 weeks of age, cognitive dysfunction (swimming T maze, fear conditioning, odor discrimination, social interaction was not evident by 94 weeks. Concomitant to behavioral assessments, T2-weighted MRI volume measurements indicated a slower striatal growth with a significant difference between wild type (WT and HdhQ150 mice being present even at 15 weeks. Indeed, MRI indicated significant volumetric changes prior to the emergence of the "clinical horizon" of motor impairments at 36 weeks of age. A striatal decrease of 27% was observed over 94 weeks with cortex (12% and hippocampus (21% also indicating significant atrophy. A hypothesis-free analysis using tensor-based morphometry highlighted further regions undergoing atrophy by contrasting brain growth and regional neurodegeneration. Histology revealed the widespread presence of mHTT aggregates and cellular inclusions. However, there was little evidence of correlations between these outcome measures, potentially indicating that other factors are important in the causal cascade linking the molecular pathology to the emergence of behavioral impairments. In conclusion, the HdhQ150 mouse model replicates many aspects of the human condition, including an extended pre-manifest period prior to the emergence of motor impairments.

  16. Both exposure to a novel context and associative learning induce an upregulation of AKAP150 protein in mouse hippocampus

    NARCIS (Netherlands)

    Nijholt, Ingrid M.; Ostroveanu, Anghelus; de Bruyn, Marco; Luiten, Paul G. M.; Eisel, Ulrich L. M.; Van der Zee, Eddy A.

    A-kinase anchoring protein 150 (AKAP150) is a multi-enzyme signaling complex that coordinates the action of PKA, PKC, and PP2B at neuronal membranes and synapses. We measured levels of AKAP150 protein in the hippocampus 6 It after training mice in a contextual fear conditioning paradigm. In

  17. 41 CFR 102-85.150 - How will Rent charges be reflected on the customer agency's Rent bill?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How will Rent charges be reflected on the customer agency's Rent bill? 102-85.150 Section 102-85.150 Public Contracts and Property... PROPERTY 85-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Rent Charges § 102-85.150 How will Rent charges be...

  18. 12 CFR 551.150 - How do my officers and employees file reports of personal securities trading transactions?

    Science.gov (United States)

    2010-01-01

    ... of personal securities trading transactions? 551.150 Section 551.150 Banks and Banking OFFICE OF... TRANSACTIONS Securities Trading Policies and Procedures § 551.150 How do my officers and employees file reports of personal securities trading transactions? An officer or employee described in § 551.140(d) must...

  19. 33 CFR 150.905 - Why are safety zones, no anchoring areas, and areas to be avoided established?

    Science.gov (United States)

    2010-07-01

    ... International Maritime Organization (IMO). An NAA, specifically established to protect vessels in transit and... anchoring areas, and areas to be avoided established? 150.905 Section 150.905 Navigation and Navigable...: OPERATIONS Safety Zones, No Anchoring Areas, and Areas To Be Avoided § 150.905 Why are safety zones, no...

  20. 33 CFR 150.505 - When must the operator service and examine lifeboat and rescue boat release gear?

    Science.gov (United States)

    2010-07-01

    ... and examine lifeboat and rescue boat release gear? 150.505 Section 150.505 Navigation and Navigable... and examine lifeboat and rescue boat release gear? (a) The operator must service lifeboat and rescue boat release gear at intervals recommended in the manufacturer's instructions under § 150.502(a), or...

  1. 33 CFR 334.150 - Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory.

    Science.gov (United States)

    2010-07-01

    ....; experimental test area, U.S. Navy Marine Engineering Laboratory. 334.150 Section 334.150 Navigation and... RESTRICTED AREA REGULATIONS § 334.150 Severn River at Annapolis, Md.; experimental test area, U.S. Navy Marine Engineering Laboratory. (a) The restricted area. The waters of Severn River shoreward of a line...

  2. 32 CFR Appendix A to Part 150 - Format for Direction for Review in a Court of Criminal Appeals

    Science.gov (United States)

    2010-07-01

    ... PROCEDURE Pt. 150, App. A Appendix A to Part 150—Format for Direction for Review in a Court of Criminal... 32 National Defense 1 2010-07-01 2010-07-01 false Format for Direction for Review in a Court of Criminal Appeals A Appendix A to Part 150 National Defense Department of Defense OFFICE OF THE SECRETARY OF...

  3. 78 FR 13754 - Notice of Receipt of Petition for Decision That Nonconforming 2004 Ford F-150 Crew Cab Trucks...

    Science.gov (United States)

    2013-02-28

    ... Nonconforming 2004 Ford F-150 Crew Cab Trucks Manufactured for Sale in the Mexican Market Are Eligible for... a petition for a decision that 2004 Ford F-150 Crew Cab trucks manufactured for sale in the Mexican... 2004 Ford F-150 Crew Cab truck) and they are capable of being readily altered to conform to the...

  4. 33 CFR 150.820 - When must a written report of casualty be submitted, and what must it contain?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false When must a written report of casualty be submitted, and what must it contain? 150.820 Section 150.820 Navigation and Navigable Waters... this section serves as the notice required under § 150.815. (d) The operator will ensure that the...

  5. 20 CFR 668.150 - What definitions apply to terms used in the regulations in this part?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What definitions apply to terms used in the regulations in this part? 668.150 Section 668.150 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION... Purposes and Policies § 668.150 What definitions apply to terms used in the regulations in this part? In...

  6. The effect of HCV Core protein on the expression of miR-150

    Directory of Open Access Journals (Sweden)

    Sayad Khanizadeh

    2016-09-01

    Full Text Available Background : Hepatitis C virus (HCV is considered as one of the major pathogenic agents of chronic liver diseases. Previous studies have shown that HCV proteins can interaction with gene regulatory networks such as microRNAs. The aim of this study was to investigate the effect of HCV core protein on the expression of miR-150 in a cell culture model. Materials and Methods: Plasmids expressing full HCV core protein was transfected into Huh7 cell lines while a GFP expressing plasmid employed as negative control. Subsequently, total RNA extracted and Real-Time PCR performed to measure the expression level of miR-150 expression. Moreover, trypan blue exclusion assay was performed to investigate the effect of core protein on cell viability. Results: The gene expression analysis of miR-150 in Huh7 cells showed that endogenous HCV core protein could significantly down regulation of miR-150 when compared to GFP control plasmid and normal cells (P<0.01. Beside, core protein induced no significant proliferative or cytotoxic effects on hepatic cells as determined by trypan blue exclusion assay (P<0.05. Conclusion: Our study suggests that HCV core protein can led to down regulation of miR-150 expression. This data revealed that HCV protein interactions with cell regulatory machinery may contribute to pathogenesis of chronic liver diseases.

  7. 150 kW Class Solar Electric Propulsion Spacecraft Power Architecture Model

    Science.gov (United States)

    Csank, Jeffrey T.; Aulisio, Michael V.; Loop, Benjamin

    2017-01-01

    The National Aeronautics and Space Administration (NASA) Solar Electric Propulsion Technology Demonstration Mission in conjunction with PC Krause and Associates has created a Simulink-based power architecture model for a 50 kilo-Watt (kW) solar electric propulsion system. NASA has extended this model to investigate 150 kW solar electric propulsion systems. Increasing the power system capability from 50 kW to 150 kW better aligns with the anticipated power requirements for Mars and other deep space explorations. The high-power solar electric propulsion capability has been identified as a critical part of NASAs future beyond-low-Earth-orbit for human-crewed exploration missions. This paper presents multiple 150 kW architectures, simulation results, and a discussion of their merits.

  8. Missense mutation (E150K) of rhodopsin in autosomal recessive retinitis pigmentosa

    Energy Technology Data Exchange (ETDEWEB)

    Orth, U.; Oehlmann, R.; Gal, A. [Inst. Humangenetik, Med. Univ., Luebeck (Germany)] [and others

    1994-09-01

    Missense or nonsense mutations of the rhodopsin gene have been implied in the pathogenesis of at least 3 different traits; autosomal dominant retinitis pigmentosa (adRP), congenital stationary night blindness (CSNB), and autosomal recessive retinitis pigmentosa (arRP). For the latter, a single patient has been reported with a nonsense mutation at codon 249 on both alleles. Heterozygous carriers of missense mutations of rhodopsin develop either adRP or CSNB depending on the particular amino acid substitution. Four of the 9 siblings from a consanguineous marriage in southern India were reported the have arRP. Mutational screening and sequencing of the rhodopsin gene revealed a G-to-A transition of the first nucleotide at codon 150 in exon II, which alters glutamate to lysine. The E150K mutation was present in the 4 patients in homozygous form, whereas the parents and 2 of the siblings were heterozygotes. Two-point analysis produced a Zmax=3.46 at theta=0.00. Two unaffected siblings who are heterozygotes for the E150K mutation underwent a thorough ophthalmological and psychophysical examination. No clinical abnormalities were found although these individuals were over forty, whereas the onset of RP in their affected siblings was in the second decade. Collectively, both the genetic and clinical findings strongly suggest that the E150K mutation of rhodopsin is recessive in this family. Glu150 forms part of the CD cytoplasmic loop of rhodopsin, which has been implicated in the binding and activation of transducin. We speculate that E150K leads to RP because the mutant protein may be incapable of activating transducin. It is tempting to speculate that, in addition to mutations in the genes for rhodopsin and the {beta}-subunit of PDE, mutations in the genes for transducin may also result in arRP.

  9. [Two 150 years anniversaries: Claude Bernard's internal environment and Addison disease].

    Science.gov (United States)

    Schreiber, V

    2005-01-01

    In 2005 two 150 years anniversaries, which essentially influenced the development of modern medicine will be celebrated. French physiologist Claude Bernard from College de France published his work "Lectures on Experimental Physiology, applied to medicine" and British medical doctor T. Addison described insufficiency of adrenal cortex, today known as Addison disease.

  10. 78 FR 5703 - Delegation of Certain Functions Under Section 6 of Public Law 112-150

    Science.gov (United States)

    2013-01-25

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 78 Friday, No. 17 January 25, 2013 Part III The President Memorandum of January 15, 2013--Delegation of Certain Functions Under Section 6 of Public Law 112-150 #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register / Vol. 78 , No. 17 / Friday, January 25, 2013 /...

  11. Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064

    Directory of Open Access Journals (Sweden)

    Eliton da Silva Vasconcelos

    2013-12-01

    Full Text Available Clavulanic acid (CA is a powerful inhibitor of the beta-lactamases, enzymes produced by bacteria resistants to penicillin and cefalosporin. This molecule is produced industrially by strains of Streptomyces clavuligerus in complex media which carbon and nitrogen resources are supplied by inexpensive compounds still providing high productivity. The genetic production improvement using physical and chemical mutagenic agents is an important strategy in programs of industrial production development of bioactive metabolites. However, parental strains are susceptible to loss of their original productivity due genetic instability phenomenona. In this work, some S. clavuligerus mutant strains obtained by treatment with UV light and with MMS are compared with the wild type (Streptomyces clavuligerus ATCC 27064. The results indicated that the random mutations originated some strains with different phenotypes, most divergent demonstrated by the mutants strains named AC116, MMS 150 and MMS 54, that exhibited lack of pigmentation in their mature spores. Also, the strain MMS 150 presented a larger production of CA when cultivated in semi-synthetics media. Using other media, the wild type strain obtained a larger CA production. Besides, using the modifed complex media the MMS 150 strain showed changes in its lipolitic activity and a larger production of CA. The studies also allowed finding the best conditions for a lipase activity exhibited by wild type S. clavuligerus and the MMS150 mutant.

  12. 46 CFR Appendix III to Part 150 - Testing Procedures for Determining Exceptions to the Chart

    Science.gov (United States)

    2010-10-01

    ... Chart III Appendix III to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Procedures for Determining Exceptions to the Chart experimental procedure for evaluating binary chemical... is joined, while the other wire of each is connected to a strip-chart recorder. The thermocouple...

  13. Development of Wave Dragon from Scale 1:50 to Prototype

    DEFF Research Database (Denmark)

    Soerensen, H. C.; Friis-Madsen, E.; Panhauser, W.

    2003-01-01

    . In the period from 1998 to 2001 extensive testing on a scale 1:50 model was carried out. During the last month, testing has started on a prototype of the Wave Dragon in Nissum Bredning, Denmark (wave climate in scale 1:4.5 of the North Sea). The prototype has been grid connected in June 2003 as the world...

  14. Tallinn ostab Harju tänava krundid 150 miljoni krooni eest / Urmas Seaver

    Index Scriptorium Estoniae

    Seaver, Urmas, 1973-

    2006-01-01

    Ilmunud ka: Postimees : na russkom jazõke 26. jaan. lk. 4. Tallinn ostab OÜ-lt Celsea 150 miljoni krooni eest kuus krunti Harju tänava ääres, et rajada varemete asemele sügiseks haljasala. Tallinna abilinnapea Taavi Aasa sõnul ei ole tehing linnale kahjulik, linnavolikogu Isamaaliidu fraktsioon plaani ei toeta

  15. Siemens meelitab Eestisse 150 töökohta / Raigo Neudorf

    Index Scriptorium Estoniae

    Neudorf, Raigo

    2002-01-01

    Saksamaa elektroonikafirma Siemens tütarfirma Eestis võistleb selle eest, et tuua Eestisse emafirma 150 pakutavat töökohta majandustarkvara koostavatele spetsialistidele. Tabelid: Siemens Grupp Eesti tähtsamad majandusnäitajad. Siemensi kontsern

  16. Pärnus valmivad kalapüügilandid 150 riigi tarvis / Raigo Neudorf

    Index Scriptorium Estoniae

    Neudorf, Raigo

    2007-01-01

    Kuigi Rapala Eesti näol on tegu Soomes asuva kontserni ühe tütarfirmaga, on Pärnus asuv tehas kontserni suurim tootmisüksus, kelle toodangut eksporditakse 150 riiki. Lisa: Fakte Rapala kohta; 1936: eduloo algus. Vt. samas: Korzhets hindab Rapala kvaliteeti

  17. Kolhoosiaja märke ei saa lammutada 150 000 eest / Signe Kalberg

    Index Scriptorium Estoniae

    Kalberg, Signe, 1959-

    2006-01-01

    Maaelu arengukavas nähakse lammutustoetuseks ette 150 000 krooni, mõnedel hinnangutel on see liiga väike summa. Eestimaa talupidajate keskliidu juhatuse liige Tiiu Hellermaa on seisukohal, et ümbruse korrastamiseks on võimalik leida raha LEADER-i meetme alt. Lisa: Raha antakse näpuotsaga

  18. Planck intermediate results. XXVI. Optical identification and redshifts of Planck clusters with the RTT150 telescope

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Arnaud, M.

    2015-01-01

    We present the results of approximately three years of observations of Planck Sunyaev-Zeldovich (SZ) sources with the Russian-Turkish 1.5m telescope (RTT150), as a part of the optical follow-up programme undertaken by the Planck collaboration. During this time period approximately 20% of all dark...

  19. Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques

    NARCIS (Netherlands)

    de Swart, Rik L.; Ludlow, Martin; de Witte, Lot; Yanagi, Yusuke; van Amerongen, Geert; McQuaid, Stephen; Yüksel, Selma; Geijtenbeek, Teunis B. H.; Duprex, W. Paul; Osterhaus, Albert D. M. E.

    2007-01-01

    Measles virus (MV) is hypothesized to enter the host by infecting epithelial cells of the respiratory tract, followed by viremia mediated by infected monocytes. However, neither of these cell types express signaling lymphocyte activation molecule (CD150), which has been identified as the receptor

  20. Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques.

    NARCIS (Netherlands)

    R.L. de Swart (Rik); M. Ludlow (Martin); L. de Witte (Lot); Y. Yanagi (Yusuke); G. van Amerongen (Geert); S. McQuaid (Stephen); S. Yüksel (Selma); T.B.H. Geijtenbeek (Teunis); W.P. Duprex (Paul); A.D.M.E. Osterhaus (Albert)

    2007-01-01

    textabstractMeasles virus (MV) is hypothesized to enter the host by infecting epithelial cells of the respiratory tract, followed by viremia mediated by infected monocytes. However, neither of these cell types express signaling lymphocyte activation molecule (CD150), which has been identified as the

  1. 45 CFR 150.305 - Determination of entity liable for civil money penalty.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Determination of entity liable for civil money... With Respect to Issuers and Non-Federal Governmental Plans-Civil Money Penalties § 150.305 Determination of entity liable for civil money penalty. If a failure to comply is established under this Part...

  2. ‘Praise beyond Words’: Psalm 150 as grand finale of the crescendo in the Psalter

    Directory of Open Access Journals (Sweden)

    Dirk J. Human

    2011-04-01

    Full Text Available Without doubt the final hymn of the Psalter can be described as the climax, or grand finale, of the Israelite faith’s most known hymnbook. In this psalm, sound and action are blended into a picture of ecstatic joy. The whole universe is called upon to magnify Yah(weh, the God of Israel. The text poses various exegetical challenges. In the past, Psalm 150 was traditionally analysed as a single text; but with the advent of the canonical and redactionhistorical approaches to the interpretation of the Book of Psalms, Psalm 150 can be interpreted as part of the final Hallel (Pss 146–150, or Book V (Pss 107–150 of the Psalter. This view opens up new possibilities for reading the psalm in broader contexts and its broader literary context(s illuminate its theological significance. This article is an attempt at reflecting on the psalm’s context(s, structure, Gattung and dates of origin, tradition-historical relations to the Pentateuch, Psalms and other Old Testament texts. Ultimately some reflections on the psalm’s theological significance will be suggested.

  3. Psalm 150 as grand finale of the crescendo in the Psalter

    African Journals Online (AJOL)

    Test

    2010-09-01

    Sep 1, 2010 ... The whole universe is called upon to magnify Yah(weh), the. God of Israel. The text poses various ... psalm's context(s), structure, Gattung and dates of origin, tradition-historical relations to the. Pentateuch, Psalms and other .... being in the universe who should praise him (Ps 150). In both Psalms 147:7 and ...

  4. 33 CFR 150.626 - What is the hazard communication program used for?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What is the hazard communication... HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Hazard Communication Program § 150.626 What is the hazard communication program used for? (a) The hazard...

  5. Oral Health And Diabetes: A Review Of 150 Patients Attending The ...

    African Journals Online (AJOL)

    Background: Diabetes mellitus is a metabolic disease which may have an effect on the gingival status and may aggravate pre-existing oral disease. Routine dental evaluation is therefore necessary in its management. The purpose of this article is to investigate the oral health status of one 150 Diabetic patients who attend ...

  6. 14 CFR 150.21 - Noise exposure maps and related descriptions.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Noise exposure maps and related... TRANSPORTATION (CONTINUED) AIRPORTS AIRPORT NOISE COMPATIBILITY PLANNING Development of Noise Exposure Maps and Noise Compatibility Programs § 150.21 Noise exposure maps and related descriptions. (a) Each airport...

  7. Cavity Optomechnics with 150nm-thick GaAs Membrane

    DEFF Research Database (Denmark)

    Usami, K.; Melholt Nielsen, B.; Naesby, A.

    2010-01-01

    semiconductor integrated devices further. To investigate the optomechanical properties of a fabricated 150nm-thick intrinsic GaAs membrane (1.3mm1.9mm) a 975nm-laser (below band gap) is used to probe the mechanical resonances via beam deflection method. An 810nmlaser (above band gap), which is mode...

  8. Phylogenetic associations of ISAa1 and IS150-like insertion sequences in Actinobacillus actinomycetemcomitans

    DEFF Research Database (Denmark)

    Hayashida, H; Poulsen, Knud; Takagi, O

    2000-01-01

    The distribution and number of two insertion sequences (ISs), ISAa1 and an IS150-like element, in the genomes of a collection of Actinobacillus actinomycetemcomitans strains previously subjected to population genetic analysis were determined to obtain information about their stability and biologi...... to housekeeping genes, but no evidence of structural disruption of genes or integrations that may be presumed to influence pathogenic potential....

  9. 21 CFR 358.150 - Labeling of wart remover drug products.

    Science.gov (United States)

    2010-04-01

    ... Section 358.150 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS FOR HUMAN USE MISCELLANEOUS EXTERNAL DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE Wart... its location only on the bottom of the foot, its tenderness, and the interruption of the footprint...

  10. 10 CFR 150.15a - Continued Commission authority pertaining to byproduct material.

    Science.gov (United States)

    2010-01-01

    ..., maintenance and emergency measures as are necessary to protect the public health and safety and other actions... REGULATORY AUTHORITY IN AGREEMENT STATES AND IN OFFSHORE WATERS UNDER SECTION 274 Continued Commission Regulatory Authority in Agreement States § 150.15a Continued Commission authority pertaining to byproduct...

  11. ETV Report: Siemens Model V-40R-A150 Open Channel UV System

    Science.gov (United States)

    Verification testing of the Siemens Barrier Sunlight V-40R-A150 UV System was completed at the UV Validation and Research Center of New York (UV Center), located in Johnstown, NY. The V-40R System supplied by Siemens utilizes 40 high-output, low-pressure amalgam lamps, oriented ...

  12. 33 CFR 150.622 - What are the warning sign requirements?

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What are the warning sign... SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS Workplace Safety and Health Warning Signs § 150.622 What are the warning sign requirements? The construction and use of warning signs must be in...

  13. Applications of Flexible Ultrasonic Transducer Array for Defect Detection at 150 °C

    Directory of Open Access Journals (Sweden)

    Jiunn-Woei Liaw

    2013-01-01

    Full Text Available In this study, the feasibility of using a one dimensional 16-element flexible ultrasonic transducer (FUT array for nondestructive testing at 150 °C is demonstrated. The FUT arrays were made by a sol-gel sprayed piezoelectric film technology; a PZT composite film was sprayed on a titanium foil of 75 µm thickness. Since the FUT array is flexible, it was attached to a steel pipe with an outer diameter of 89 mm and a wall thickness of 6.5 mm at 150 °C. Using the ultrasonic pulse-echo mode, pipe thickness measurements could be performed. Moreover, using the ultrasonic pulse-echo and pitch-catch modes of each element of FUT array, the defect detection was performed on an Al alloy block of 30 mm thickness with a side-drilled hole (SDH of f3 mm at 150 °C. In addition, a post-processing algorithm based on the total focusing method was used to process the full matrix of these A-scan signals of each single transmitter and multi-receivers, and then the phase-array image was obtained to indicate this defect- SDH. Both results show the capability of FUT array being operated at 150 °C for the corrosion and defect detections.

  14. Characterization of Cell Wall Proteins in Saccharomyces cerevisiae Clinical Isolates Elucidates Hsp150p in Virulence.

    Directory of Open Access Journals (Sweden)

    Pang-Hung Hsu

    Full Text Available The budding yeast Saccharomyces cerevisiae has recently been described as an emerging opportunistic fungal pathogen. Fungal cell wall mannoproteins have been demonstrated to be involved in adhesion to inert surfaces and might be engaged in virulence. In this study, we observed four clinical isolates of S. cerevisiae with relatively hydrophobic cell surfaces. Yeast cell wall subproteome was evaluated quantitatively by liquid chromatography/tandem mass spectrometry. We identified totally 25 cell wall proteins (CWPs from log-phase cells, within which 15 CWPs were quantified. The abundance of Scw10p, Pst1p, and Hsp150p/Pir2p were at least 2 folds higher in the clinical isolates than in S288c lab strain. Hsp150p is one of the members in Pir family conserved in pathogenic fungi Candida glabrata and Candida albicans. Overexpression of Hsp150p in lab strain increased cell wall integrity and potentially enhanced the virulence of yeast. Altogether, these results demonstrated that quantitative cell wall subproteome was analyzed in clinical isolates of S. cerevisiae, and several CWPs, especially Hsp150p, were found to be expressed at higher levels which presumably contribute to strain virulence and fungal pathogenicity.

  15. ‘Praise beyond Words’: Psalm 150 as grand finale of the crescendo in the Psalter

    Directory of Open Access Journals (Sweden)

    Dirk J. Human

    2011-06-01

    Full Text Available Without doubt the final hymn of the Psalter can be described as the climax, or grand finale, of the Israelite faith’s most known hymnbook. In this psalm, sound and action are blended into a picture of ecstatic joy. The whole universe is called upon to magnify Yah(weh, the God of Israel. The text poses various exegetical challenges. In the past, Psalm 150 was traditionally analysed as a single text; but with the advent of the canonical and redactionhistorical approaches to the interpretation of the Book of Psalms, Psalm 150 can be interpreted as part of the final Hallel (Pss 146–150, or Book V (Pss 107–150 of the Psalter. This view opens up new possibilities for reading the psalm in broader contexts and its broader literary context(s illuminate its theological significance. This article is an attempt at reflecting on the psalm’s context(s, structure, Gattung and dates of origin, tradition-historical relations to the Pentateuch, Psalms and other Old Testament texts. Ultimately some reflections on the psalm’s theological significance will be suggested.

  16. Page 1 278 S. KANTHAMANI and heated to 150° in an oil-bath, was ...

    Indian Academy of Sciences (India)

    and heated to 150° in an oil-bath, was treated with 8-naphthylamine (5 g) the amine being added in small lots extending over a period of 5 minutes. After addition was complete, the temperature of the bath was raised to 180° and maintained at that point for half an hour. The cooled product was repeatedly extracted with ...

  17. Intracellular modulation, extracellular disposal and serum increase of MiR-150 mark lymphocyte activation.

    Directory of Open Access Journals (Sweden)

    Paola de Candia

    Full Text Available Activated lymphocytes release nano-sized vesicles (exosomes containing microRNAs that can be monitored in the bloodstream. We asked whether elicitation of immune responses is followed by release of lymphocyte-specific microRNAs. We found that, upon activation in vitro, human and mouse lymphocytes down-modulate intracellular miR-150 and accumulate it in exosomes. In vivo, miR-150 levels increased significantly in serum of humans immunized with flu vaccines and in mice immunized with ovalbumin, and this increase correlated with elevation of antibody titers. Immunization of immune-deficient mice, lacking MHCII, resulted neither in antibody production nor in elevation of circulating miR-150. This study provides proof of concept that serum microRNAs can be detected, with minimally invasive procedure, as biomarkers of vaccination and more in general of adaptive immune responses. Furthermore, the prompt reduction of intracellular level of miR-150, a key regulator of mRNAs critical for lymphocyte differentiation and functions, linked to its release in the external milieu suggests that the selective extracellular disposal of microRNAs can be a rapid way to regulate gene expression during lymphocyte activation.

  18. 21 CFR 333.150 - Labeling of first aid antibiotic drug products.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Labeling of first aid antibiotic drug products... First Aid Antibiotic Drug Products § 333.150 Labeling of first aid antibiotic drug products. (a... identifies the product as a “first aid antibiotic.” (b) Indications. The labeling of the product states...

  19. PERSPECTIVES OF MODERNIZATION OF WIRE MILL OF HOT ROLLING 150 AT RUP “BMZ”

    Directory of Open Access Journals (Sweden)

    A. V. Gontarj

    2004-01-01

    Full Text Available The offered modernization of the mill presumes the increase of capacity of the small-sort wire mill of hot milling 150 approximately till 40% at reduction of cost of the produced on it rolled wire by 15%, that will allow in future as well to grow the volumes of hardware production.

  20. 77 FR 29531 - 150th Anniversary of the United States Department of Agriculture

    Science.gov (United States)

    2012-05-18

    ... of May 14, 2012 150th Anniversary of the United States Department of Agriculture By the President of... legislation to establish the United States Department of Agriculture (USDA) and codified a commitment to the... vision of service by applying sound public policy and science to an evolving food and agriculture system...

  1. Naturally enhanced ion-line spectra around the equatorial 150-km region

    Directory of Open Access Journals (Sweden)

    J. L. Chau

    2009-03-01

    Full Text Available For many years strong radar echoes coming from 140–170 km altitudes at low latitudes have been associated to the existence of field-aligned irregularities (FAIs (the so called 150-km echoes. In this work, we present frequency spectra as well as angular distribution of 150-km echoes. When the 150-km region is observed with beams perpendicular to the magnetic field (B the observed radar spectra are very narrow with spectral widths between 3–12 m/s. On the other hand, when few-degrees off-perpendicular beams are used, the radar spectra are wide with spectral widths comparable to those expected from ion-acoustic waves at these altitudes (>1000 m/s. Moreover the off-perpendicular spectral width increases with increasing altitude. The strength of the received echoes is one to two orders of magnitude stronger than the expected level of waves in thermal equilibrium at these altitudes. Such enhancement is not due to an increase in electron density. Except for the enhancement in power, the spectra characteristics of off-perpendicular and perpendicular echoes are in reasonable agreement with expected incoherent scatter spectra at these angles and altitudes. 150-km echoes are usually observed in narrow layers (2 to 5. Bistatic common volume observations as well as observations made few kilometers apart show that, for most of the layers, there is very high correlation on power fluctuations without a noticeable time separation between simultaneous echoes observed with Off-perpendicular and Perpendicular beams. However, in one of the central layers, the echoes are the strongest in the perpendicular beam and absent or very weak in the off-perpendicular beams, suggesting that they are generated by a plasma instability. Our results indicate that most echoes around 150-km region are not as aspect sensitive as originally thought, and they come from waves that have been enhanced above waves in thermal equilibrium.

  2. Deep GMRT 150-MHz observations of the LBDS-Lynx region: ultrasteep spectrum radio sources

    Science.gov (United States)

    Ishwara-Chandra, C. H.; Sirothia, S. K.; Wadadekar, Y.; Pal, S.; Windhorst, R.

    2010-06-01

    It has been known for nearly three decades that high-redshift radio galaxies exhibit steep radio spectra, and hence ultrasteep spectrum radio sources provide candidates for high-redshift radio galaxies. Nearly all radio galaxies with z > 3 have been found using this redshift-spectral index correlation. We have started a programme with the Giant Metrewave Radio Telescope (GMRT) to exploit this correlation at flux density levels about 10 to 100 times deeper than the known high-redshift radio galaxies which were identified primarily using the already available radio catalogues. In our programme, we have obtained deep, high-resolution radio observations at 150 MHz with GMRT for several `deep' fields which are well studied at higher radio frequencies and in other bands of the electromagnetic spectrum, with an aim to detect candidate high-redshift radio galaxies. In this paper we present results from the deep 150-MHz observations of the LBDS-Lynx field, which has been already imaged at 327, 610 and 1412 MHz with the Westerbork Synthesis Radio Telescope and at 1400 and 4860 MHz with the Very Large Array. The 150-MHz image made with GMRT has an rms noise of ˜0.7 mJy beam-1 and a resolution of ˜19 × 15 arcsec2. It is the deepest low-frequency image of the LBDS-Lynx field. The source catalogue of this field at 150 MHz has about 765 sources down to ˜20 per cent of the primary beam response, covering an area of about 15 deg2. Spectral index was estimated by cross-correlating each source detected at 150 MHz with the available observations at 327, 610, 1400 and 4860 MHz and also using available radio surveys such as the Westerbork Northern Sky Survey at 327 MHz and the NRAO VLA Sky Survey and Faint Images of the Radio Sky at Twenty-cm at 1400 MHz. We find about 150 radio sources with spectra steeper than 1. About two-third of these are not detected in the Sloan Digital Sky Survey, hence are strong candidate high-redshift radio galaxies, which need to be further explored with

  3. miR-150-5p inhibits hepatoma cell migration and invasion by targeting MMP14.

    Directory of Open Access Journals (Sweden)

    Tao Li

    Full Text Available Hepatocellular carcinoma (HCC is one of the leading causes of cancer-related mortality worldwide. Despite progress in diagnostics and treatment of HCC, its prognosis remains poor because the molecular mechanisms underlying hepatocarcinogenesis are not well understood. In the study, we focused on identifying the role of miRNAs in HCC progression. miRNA microarray was used to analyze the differentially expressed miRNAs, and the results were validated by qPCR. We found that the miR-150-5p expression is down-regulated in HCC tissues compared with pair non-tumor tissues. miR-150-5p expression is also decreased in metastatic cancer tissues compared with pair primary tissues, indicating that miR-150-5p may be involved in HCC metastasis. Functionally, miR-150-5p inhibition significantly promotes hepatoma cell migration and invasion, whereas miR-150-5p overexpression suppresses cancer cell migration and invasion in vitro. The matrix metalloproteinase 14 (MMP14 is identified as a new target gene of miR-150-5p. miR-150-5p markedly inhibits MMP14 expression in hepatoma cells, and miR-150-5p expression is negative correlation with MMP14 expression in vivo. More important, re-expression of MMP14 in hepatoma cells partially reverses the effect of miR-150-5p in inhibiting cell invasion.

  4. miR-150 suppresses the proliferation and tumorigenicity of leukemia stem cells by targeting the Nanog signaling pathway

    Directory of Open Access Journals (Sweden)

    Dan-dan Xu

    2016-11-01

    Full Text Available Proliferation, a key feature of cancer cells, accounts for the majority of cancer-related diseases resulting in mortality. MicroRNAs (miRNAs plays important post-transcriptional modulation roles by acting on multiple signaling pathways, but the underlying mechanism in proliferation and tumorigenicity is unclear. Here, we identified the role of miR-150 in proliferation and tumorigenicity in leukemia stem cells (LSCs (CD34+CD38- cells. miR-150 expression was significantly down-regulated in LSCs from leukemia cell lines and clinical samples. Functional assays demonstrated that increased miR-150 expression inhibited proliferation and clonal and clonogenic growth, enhanced chemosensitivity, and attenuated tumorigenic activity of LSCs in vitro. Transplantation animal studies revealed that miR-150 overexpression progressively abrogates tumour growth. Immunohistochemistry assays demonstrated that miR-150 overexpression enhanced caspase-3 level and reduced Ki-67 level. Moreover, luciferase reporter assays indicated Nanog is a direct and functional target of miR-150. Nanog silencing using small interfering RNA recapitulated anti-proliferation and tumorigenicity inhibition effects. Furthermore, miR-150 directly down-regulated the expression of other cancer stem cell factors including Notch2 and CTNNB1. These results provide insights into the specific biological behaviour of miR-150 in regulating LSC proliferation and tumorigenicity. Targeting this miR-150/Nanog axis would be a helpful therapeutic strategy to treat acute myeloid leukemia.

  5. Transfer and expression of the gene encoding a human myeloid membrane antigen (gp150).

    Science.gov (United States)

    Look, A T; Peiper, S C; Rebentisch, M B; Ashmun, R A; Roussel, M F; Rettenmier, C W; Sherr, C J

    1985-02-01

    DNA from the human myeloid cell line HL-60 was cotransfected with the cloned thymidine kinase (tk) gene of herpes simplex virus into tk-deficient mouse L cells. tk-positive recipients expressing antigens detected on HL-60 cells were isolated with a fluorescence-activated cell sorter by use of a panel of monoclonal antibodies that detect epitopes on both normal and malignant myeloid cells. Independently sorted populations of transformed mouse cells showed concordant reactivities with four of the monoclonal antibodies in the panel (DU-HL60-4, MY7, MCS.2, and SJ-D1), which suggested that these antibodies reacted to products of a single human gene. A second round of DNA transfection and cell sorting was performed with donor DNA from primary transformants. Two different dominant selection systems were used to isolate secondary mouse L cell and NIH/3T3 cell transformants that coexpressed the same epitopes. Analysis of cellular DNA from secondary mouse cell subclones with a probe specific for human repetitive DNA sequences revealed a minimal human DNA complement containing a characteristic set of restriction fragments common to independently derived subclones. Two glycoproteins, of 130,000 (gp130) and 150,000 (gp150) mol wt, were specifically immunoprecipitated from metabolically labeled lysates of mouse cell transformants and were shown to contain [35S]methionine-labeled tryptic peptides identical to those of analogous glycoproteins expressed in the donor human myeloid cell line. Kinetic and biochemical analyses established that gp130 is a precursor that differs in its carbohydrate moiety from gp150, the mature form of the glycoprotein detected on the cell surface. The isolation of human gene sequences encoding gp150 in a mouse cell genetic background provides the possibility of molecularly cloning the gene and represents a general strategy for isolating human genes encoding differentiation-specific cell surface antigens.

  6. VizieR Online Data Catalog: Bootes field LOFAR 150-MHz observations (Williams+, 2016)

    Science.gov (United States)

    Williams, W. L.; van Weeren, R. J.; Rottgering, H. J. A.; Best, P.; Dijkema, T. J.; de Gasperin, F.; Hardcastle, M. J.; Heald, G.; Prandoni, I.; Sabater, J.; Shimwell, T. W.; Tasse, C.; van Bemmel, I. M.; Bruggen, M.; Brunetti, G.; Conway, J. E.; Ensslin, T.; Engels, D.; Falcke, H.; Ferrari, C.; Haverkorn, M.; Jackson, N.; Jarvis, M. J.; Kapinska, A. D.; Mahony, E. K.; Miley, G. K.; Morabito, L. K.; Morganti, R.; Orru, E.; Retana-Montenegro, E.; Sridhar, S. S.; Toribio, M. C.; White, G. J.; Wise, M. W.; Zwart, J. T. L.

    2017-11-01

    Here, we report on the first LOFAR Cycle 2 High Band Antenna (HBA) observations of the Bootes field. The Bootes field is one of the Tier-3 Survey fields, and the aim is to eventually survey this field to the extreme rms depth of 12uJy/beam (1σ) at 150MHz. The Bootes field was observed on 2014 August 10 with the LOFAR HBA stations. (2 data files).

  7. VISCOSITY OF AQUEOUS SODIUM CHLORIDE SOLUTIONS FROM 0 - 150o C

    Energy Technology Data Exchange (ETDEWEB)

    Ozbek, H.; Fair, J.A.; Phillips, S.L.

    1977-10-01

    A critical evaluation of data on the viscosity of aqueous sodium chloride solutions is presented. The literature was screened through October 1977, and a databank of evaluated data was established. Viscosity values were converted when necessary to units of centigrade, centipoise and molal concentration. The data were correlated with the aid of an empirical equation to facilitate interpolation and computer calculations. The result of the evaluation includes a table containing smoothed values for the viscosity of NaCl solutions to 150 C.

  8. Direct Imaging of a Toroidal Magnetic Field in the Inner Jet of NRAO 150

    Directory of Open Access Journals (Sweden)

    Sol N. Molina

    2016-11-01

    Full Text Available Most formation models and numerical simulations cause a helical magnetic field to form, accelerate and collimate jets in active galactic nuclei (AGN. For this reason, observational direct evidence for the existence of these helical magnetic fields is of special relevance. In this work, we present ultra- high-resolution observations of the innermost regions of the jet in the quasar NRAO150. We study the polarization structure and report evidence of a helical magnetic field.

  9. Streptococcus sanguis expresses a 150-kilodalton two-domain adhesin: characterization of several independent adhesin epitopes.

    Science.gov (United States)

    Gong, K; Herzberg, M C

    1997-09-01

    Streptococcus sanguis binds to saliva-coated hydroxylapatite (sHA), an in vitro model of the enamel pellicle. To learn if more than one adhesin functions during adhesion, 12 reactive monoclonal antibodies (MAbs) were isolated by screening against both adhesive and nonadhesive strains. Two of these MAbs, 1.1 and 1.2, inhibited adhesion in a dose-dependent fashion, although maximum inhibition with either was only 37%. When these two MAbs plus a polyclonal antibody to P1-like adhesin were combined, the inhibition was additive to about 82%. These data indicated that there were at least three distinct, functional adhesion epitopes on the surface of S. sanguis. Western blot analyses of S. sanguis surface macromolecules showed antigens at 36 and 56 (with MAb 1.2), 87 and 150 (with both MAb 1.1 and MAb 1.2), and 100, 130, and 170 kDa (with anti-P1 antibody). The antigens were eluted from gels. Isolated antigens and corresponding antibodies inhibited adhesion similarly. Additivity experiments suggested the distinct epitopes were in three groups: (i) 36/56 kDa, (ii) 87/150 kDa, and (iii) 100/130/170 kDa. The 150-kDa antigen reacting with both MAbs was isolated from gels and digested with trypsin. The digestion revealed a series of tryptic bands. A band at 38 kDa reacted with MAb 1.1 whereas a band at 54 kDa reacted with MAb 1.2 in Western blot analysis, indicating two distinct adhesive epitopes on the 150-kDa antigen. These data strongly suggest that S. sanguis adhesion to sHA is maximized when several adhesin epitopes are coexpressed on surface antigens of different sizes.

  10. Backpropagation Neural Network Modeling for Fault Location in Transmission Line 150 kV

    Directory of Open Access Journals (Sweden)

    Azriyenni Narwan

    2014-03-01

    Full Text Available In this topic research was provided about the backpropagation neural network to detect fault location in transmission line 150 kV between substation to substation. The distance relay is one of the good protective device and safety devices that often used on transmission line 150 kV. The disturbances in power system are used distance relay protection equipment in the transmission line. However, it needs more increasing large load and network systems are increasing complex. The protection system use the digital control, in order to avoid the error calculation of the distance relay impedance settings and spent time will be more efficient. Then backpropagation neural network is a computational model that uses the training process that can be used to solve the problem of work limitations of distance protection relays. The backpropagation neural network does not have limitations cause of the impedance range setting. If the output gives the wrong result, so the correct of the weights can be minimized and also the response of galat, the backpropagation neural network is expected to be closer to the correct value. In the end, backpropagation neural network modeling is expected to detect the fault location and identify operational output current circuit breaker was tripped it. The tests are performance with interconnected system 150 kV of Riau Region.

  11. Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.

    Science.gov (United States)

    Li, Lei; Li, Jing; Drum, Benjamin M; Chen, Yi; Yin, Haifeng; Guo, Xiaoyun; Luckey, Stephen W; Gilbert, Merle L; McKnight, G Stanley; Scott, John D; Santana, L Fernando; Liu, Qinghang

    2017-02-01

    Impaired Ca2 + cycling and myocyte contractility are a hallmark of heart failure triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring protein AKAP150 has been shown to coordinate key aspects of adrenergic regulation of Ca2+ cycling and excitation-contraction in cardiomyocytes. However, the role of the AKAP150 signalling complexes in the pathogenesis of heart failure has not been investigated. Here we examined how AKAP150 signalling complexes impact Ca2+ cycling, myocyte contractility, and heart failure susceptibility following pathological stress. We detected a significant reduction of AKAP150 expression in the failing mouse heart induced by pressure overload. Importantly, cardiac-specific AKAP150 knockout mice were predisposed to develop dilated cardiomyopathy with severe cardiac dysfunction and fibrosis after pressure overload. Loss of AKAP150 also promoted pathological remodelling and heart failure progression following myocardial infarction. However, ablation of AKAP150 did not affect calcineurin-nuclear factor of activated T cells signalling in cardiomyocytes or pressure overload- or agonist-induced cardiac hypertrophy. Immunoprecipitation studies showed that AKAP150 was associated with SERCA2, phospholamban, and ryanodine receptor-2, providing a targeted control of sarcoplasmic reticulum Ca2+ regulatory proteins. Mechanistically, loss of AKAP150 led to impaired Ca2+ cycling and reduced myocyte contractility reserve following adrenergic stimulation or pressure overload. These findings define a critical role for AKAP150 in regulating Ca2+ cycling and myocardial ionotropy following pathological stress, suggesting the AKAP150 signalling pathway may serve as a novel therapeutic target for heart failure. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For Permissions, please email: journals.permissions@oup.com.

  12. Deletion of miR-150 Exacerbates Retinal Vascular Overgrowth in High-Fat-Diet Induced Diabetic Mice.

    Directory of Open Access Journals (Sweden)

    Liheng Shi

    Full Text Available Diabetic retinopathy (DR is the leading cause of blindness among American adults above 40 years old. The vascular complication in DR is a major cause of visual impairment, making finding therapeutic targets to block pathological angiogenesis a primary goal for developing DR treatments. MicroRNAs (miRs have been proposed as diagnostic biomarkers and potential therapeutic targets for various ocular diseases including DR. In diabetic animals, the expression levels of several miRs, including miR-150, are altered. The expression of miR-150 is significantly suppressed in pathological neovascularization in mice with hyperoxia-induced retinopathy. The purpose of this study was to investigate the functional role of miR-150 in the development of retinal microvasculature complications in high-fat-diet (HFD induced type 2 diabetic mice. Wild type (WT and miR-150 null mutant (miR-150-/- male mice were given a HFD (59% fat calories or normal chow diet. Chronic HFD caused a decrease of serum miR-150 in WT mice. Mice on HFD for 7 months (both WT and miR-150-/- had significant decreases in retinal light responses measured by electroretinograms (ERGs. The retinal neovascularization in miR-150-/--HFD mice was significantly higher compared to their age matched WT-HFD mice, which indicates that miR-150 null mutation exacerbates chronic HFD-induced neovascularization in the retina. Overexpression of miR-150 in cultured endothelial cells caused a significant reduction of vascular endothelial growth factor receptor 2 (VEGFR2 protein levels. Hence, deletion of miR-150 significantly increased the retinal pathological angiogenesis in HFD induced type 2 diabetic mice, which was in part through VEGFR2.

  13. Pharmacokinetics and bioequivalence of a pregabalin 150-mg capsule in healthy Thai subjects.

    Science.gov (United States)

    Prompila, Nantaporn; Eiamart, Wanna; Jumroen, Yaowatree; Sayankuldilok, Nonlanee; Chariyavilaskul, Pajaree; Ketchat, Wannarasami; Wittayalertpanya, Supeecha

    2017-10-01

    The purpose of the study was to evaluate the pharmacokinetics and bioequivalence of pregabalin following administration of a 150-mg capsule of test and reference products. The study was designed as a randomized, two-treatment, two-period, two-sequence, single-dose crossover with 1-week washout period between period I and period II dosing. 20 healthy male and female Thai subjects were enrolled in the study. Each subject was in fasted state for ~ 10 hours prior to receiving a single oral 150-mg pregabalin capsule. Serial blood samples were collected at pre-dose until 32 hours after drug administration. Plasma samples were extracted by protein precipitation and derivatized with 4-chloro-7-nitrobenzofurazan. Pregabalin plasma concentrations were determined by HPLC method, and pharmacokinetic parameters were calculated. For bioequivalence assessment, the differences of Cmax, AUC0-t, and AUC0-inf means based on ln-transformed data were assessed by the 90% confidence interval (CI). Pharmacokinetic parameters were determined that test and reference products showed 0.96 ± 0.35 and 1.04 ± 0.96 hours for tmax, 4,594.217 ± 834.195 and 4,568.68 ± 573.963 ng/mL for Cmax, 30,048.150 ± 2,998.920 and 29,315.722 ± 2,747.396 ng×h/mL for AUC0-t, 30,594.210 ± 2,872.317 and 29,831.454 ± 2,688.020 ng×h/mL for AUC0-inf, respectively. The 90% CIs of Cmax, AUC0-t, and AUC0-inf for test and reference products were assessed at 95.356 - 104.630%, 99.303 - 105.751%, and 99.373 - 105.788%, respectively. The results were within the acceptance criteria of 80 - 125%. Pharmacokinetic parameters of a single oral 150-mg pregabalin capsule in healthy Thai subjects were evaluated and showed rapid absorption. 90% CI for the differences of Cmax, AUC0-t, and AUC0-inf were within the acceptable range of the criteria so that bioequivalence of the test and reference products of pregabalin 150-mg capsule could be concluded.
.

  14. 41 CFR 102-192.150 - What are your general responsibilities as a program level mail manager?

    Science.gov (United States)

    2010-07-01

    ... responsibilities as a program level mail manager? 102-192.150 Section 102-192.150 Public Contracts and Property... general responsibilities as a program level mail manager? Your responsibilities at the program level include— (a) Working closely with the agency mail manager and mail center managers who handle significant...

  15. 33 CFR 150.511 - What are the operational testing requirements for lifeboat and rescue boat release gear?

    Science.gov (United States)

    2010-07-01

    ... requirements for lifeboat and rescue boat release gear? 150.511 Section 150.511 Navigation and Navigable Waters... operational testing requirements for lifeboat and rescue boat release gear? (a) Lifeboat and rescue boat... rescue boat when loaded with its full complement of persons and equipment. (b) The test must be conducted...

  16. 33 CFR 150.504 - When must the operator service and examine lifeboat and rescue boat launching appliances?

    Science.gov (United States)

    2010-07-01

    ... and examine lifeboat and rescue boat launching appliances? 150.504 Section 150.504 Navigation and... and examine lifeboat and rescue boat launching appliances? (a) The operator must service launching appliances for lifeboats and rescue boats at intervals recommended in the manufacturer's instructions under...

  17. Immediate treatment with bicalutamide 150mg as adjuvant therapy significantly reduces the risk of PSA progression in early prostate cancer

    DEFF Research Database (Denmark)

    See, W; Iversen, P; Wirth, M

    2003-01-01

    To evaluate the effect of bicalutamide ('Casodex') 150mg (in addition to standard care), on the risk of prostate-specific antigen (PSA) progression, in patients with early prostate cancer.......To evaluate the effect of bicalutamide ('Casodex') 150mg (in addition to standard care), on the risk of prostate-specific antigen (PSA) progression, in patients with early prostate cancer....

  18. miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.

    Science.gov (United States)

    Chen, Zeyu; Stelekati, Erietta; Kurachi, Makoto; Yu, Sixiang; Cai, Zhangying; Manne, Sasikanth; Khan, Omar; Yang, Xiaolu; Wherry, E John

    2017-09-12

    MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell development through the transcription factor c-Myb was identified. Without miR-150, c-Myb was upregulated and anti-apoptotic targets of c-Myb, such as Bcl-2 and Bcl-xL, were also increased, suggesting a miR-150-c-Myb survival circuit during memory CD8 T cell development. Indeed, overexpression of non-repressible c-Myb rescued the memory CD8 T cell defects caused by overexpression of miR-150. Overall, these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  19. 33 CFR 150.601 - What are the safety and health requirements for the workplace on a deepwater port?

    Science.gov (United States)

    2010-07-01

    ... requirements for the workplace on a deepwater port? 150.601 Section 150.601 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) DEEPWATER PORTS DEEPWATER PORTS: OPERATIONS... requirements for the workplace on a deepwater port? (a) Each operator of a deepwater port must ensure that the...

  20. 33 CFR 155.T150 - Temporary suspension of requirements to permit support of deepwater horizon spill response.

    Science.gov (United States)

    2010-07-01

    ... requirements to permit support of deepwater horizon spill response. 155.T150 Section 155.T150 Navigation and... requirements to permit support of deepwater horizon spill response. (a) Applicability. This section applies to... (OSC), as defined in 40 CFR 300.5, in support of the response to the Deepwater Horizon Spill of...

  1. 33 CFR 154.T150 - Temporary suspension of requirements to permit support of deepwater horizon spill response.

    Science.gov (United States)

    2010-07-01

    ... requirements to permit support of deepwater horizon spill response. 154.T150 Section 154.T150 Navigation and... support of deepwater horizon spill response. (a) Applicability. This section applies to— (1) Any facility... support of the response to the Deepwater Horizon Spill of National Significance; and (2) Any facility...

  2. miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb

    Directory of Open Access Journals (Sweden)

    Zeyu Chen

    2017-09-01

    Full Text Available MicroRNAs play an important role in T cell responses. However, how microRNAs regulate CD8 T cell memory remains poorly defined. Here, we found that miR-150 negatively regulates CD8 T cell memory in vivo. Genetic deletion of miR-150 disrupted the balance between memory precursor and terminal effector CD8 T cells following acute viral infection. Moreover, miR-150-deficient memory CD8 T cells were more protective upon rechallenge. A key circuit whereby miR-150 repressed memory CD8 T cell development through the transcription factor c-Myb was identified. Without miR-150, c-Myb was upregulated and anti-apoptotic targets of c-Myb, such as Bcl-2 and Bcl-xL, were also increased, suggesting a miR-150-c-Myb survival circuit during memory CD8 T cell development. Indeed, overexpression of non-repressible c-Myb rescued the memory CD8 T cell defects caused by overexpression of miR-150. Overall, these results identify a key role for miR-150 in memory CD8 T cells through a c-Myb-controlled enhanced survival circuit.

  3. The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci

    Energy Technology Data Exchange (ETDEWEB)

    Uwada, Junsuke [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555 (Japan); Global COE (Centers of Excellence) Program, Global Initiative Center for Pulsed Power Engineering, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555 (Japan); Tanaka, Niina; Yamaguchi, Yutaro; Uchimura, Yasuhiro [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555 (Japan); Shibahara, Kei-ichi [Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima (Japan); Nakao, Mitsuyoshi [Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto (Japan); Saitoh, Hisato, E-mail: hisa@kumamoto-u.ac.jp [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555 (Japan); Global COE (Centers of Excellence) Program, Global Initiative Center for Pulsed Power Engineering, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555 (Japan)

    2010-01-01

    The small ubiquitin-related modifier 2/3 (SUMO2/3) can be post-translationally conjugated to a wide variety of proteins constituting chromatin, the platform for genetic and epigenetic regulation. Nevertheless, it is unclear how SUMO2/3 and SUMO2/3-modified proteins are delivered to the chromatin fibers. Here we report that the largest subunit of chromatin assembly factor 1 (CAF-1), human p150, interacts directly and preferentially with SUMO2/3. Amino acid residue of 98-105 in p150 is essential and sufficient for SUMO2/3 interaction. p150-SUMO2/3 interaction coincided with regions that replicate chromatin fibers, because accumulation of the proliferating cell nuclear antigen (PCNA), and incorporation of bromodeoxyuridine (BrdU) were detected at foci co-localized with both p150 and SUMO2/3 during the S-phase in a cell line expressing epitope-tagged p150. Although inhibition of SUMO2/3 expression had only a small effect on p150 deposition on the replication sites, depletion of p150 led to delocalization of SUMO2/3 from the replication foci. Furthermore, p150 mutants deficient in SUMO2/3 interaction, caused a major reduction of SUMO2/3 at the replication foci. Thus, our findings suggest an expanded role of p150 as a SUMO2/3-interacting factor, and raise the intriguing possibility that p150 plays a role in promoting delivery of SUMO2/3 or SUMO2/3-modified proteins (or both) on chromatin fibers during replication.

  4. Search for Neutrinoless Quadruple-β Decay of ^{150}Nd with the NEMO-3 Detector.

    Science.gov (United States)

    Arnold, R; Augier, C; Barabash, A S; Basharina-Freshville, A; Blondel, S; Blot, S; Bongrand, M; Boursette, D; Brudanin, V; Busto, J; Caffrey, A J; Calvez, S; Cascella, M; Cerna, C; Cesar, J P; Chapon, A; Chauveau, E; Chopra, A; Dawson, L; Duchesneau, D; Durand, D; Egorov, V; Eurin, G; Evans, J J; Fajt, L; Filosofov, D; Flack, R; Garrido, X; Gómez, H; Guillon, B; Guzowski, P; Hodák, R; Huber, A; Hubert, P; Hugon, C; Jullian, S; Klimenko, A; Kochetov, O; Konovalov, S I; Kovalenko, V; Lalanne, D; Lang, K; Lemière, Y; Le Noblet, T; Liptak, Z; Liu, X R; Loaiza, P; Lutter, G; Macko, M; Macolino, C; Mamedov, F; Marquet, C; Mauger, F; Morgan, B; Mott, J; Nemchenok, I; Nomachi, M; Nova, F; Nowacki, F; Ohsumi, H; Patrick, C; Pahlka, R B; Perrot, F; Piquemal, F; Povinec, P; Přidal, P; Ramachers, Y A; Remoto, A; Reyss, J L; Riddle, C L; Rukhadze, E; Saakyan, R; Salazar, R; Sarazin, X; Shitov, Yu; Simard, L; Šimkovic, F; Smetana, A; Smolek, K; Smolnikov, A; Söldner-Rembold, S; Soulé, B; Štefánik, D; Štekl, I; Suhonen, J; Sutton, C S; Szklarz, G; Thomas, J; Timkin, V; Torre, S; Tretyak, Vl I; Tretyak, V I; Umatov, V I; Vanushin, I; Vilela, C; Vorobel, V; Waters, D; Xie, F; Žukauskas, A

    2017-07-28

    We report the results of a first experimental search for lepton number violation by four units in the neutrinoless quadruple-β decay of ^{150}Nd using a total exposure of 0.19 kg yr recorded with the NEMO-3 detector at the Modane Underground Laboratory. We find no evidence of this decay and set lower limits on the half-life in the range T_{1/2}>(1.1-3.2)×10^{21}  yr at the 90% C.L., depending on the model used for the kinematic distributions of the emitted electrons.

  5. Research and development of a 150kW tidal stream generator

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This report summarises the results of a project evaluating the technical and commercial viability of the Stingray tidal stream generator. A description is given of the Stingray with its set of large hydroplanes capturing and converting the energy from the moving water into hydraulic power and using a hydraulic motor to drive an electric generator. Details are given of the investigation stage of the project, the mathematical and physical modelling, the identification of potential sites, the parametric cost study, and the design review and detail design. A preliminary base-line design for a 150kW Stingray generator is identified.

  6. Vaporization of the prostate with 150-w thulium laser: complications with 6-month follow-up.

    Science.gov (United States)

    Vargas, César; García-Larrosa, Alejandro; Capdevila, Santiago; Laborda, Ainhoa

    2014-07-01

    Purpose: To analyze the efficacy and safety of vaporization of the prostate (VP) with the 150-W thulium:yttrium-aluminum-garnet (Tm:YAG) laser. In a prospective series of 55 patients with small- and medium-size prostates undergoing major outpatient surgery (MOS), the primary objectives were to analyze changes in maximum flow (Qmax) and International Prostate Symptom Score (IPSS) after 6 months. Immediate (30 days) complications were subsequently recorded. An increase in mean Qmax of 9.33 mL/s (95% confidence interval [CI] of the mean difference 6.73-11.93; Ptechnique with other procedures.

  7. First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC

    CERN Document Server

    Ambrosio, G; Wanderer, P; Ferracin, P; Sabbi, G

    2017-01-01

    The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb3Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to address them are also presented and discussed.

  8. First Test Results of the 150 mm Aperture IR Quadrupole Models for the High Luminosity LHC

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosio, G. [Fermilab; Chlachidze, G. [Fermilab; Wanderer, P. [Brookhaven; Ferracin, P. [CERN; Sabbi, G. [LBNL, Berkeley

    2016-10-06

    The High Luminosity upgrade of the LHC at CERN will use large aperture (150 mm) quadrupole magnets to focus the beams at the interaction points. The high field in the coils requires Nb3Sn superconductor technology, which has been brought to maturity by the LHC Accelerator Re-search Program (LARP) over the last 10 years. The key design targets for the new IR quadrupoles were established in 2012, and fabrication of model magnets started in 2014. This paper discusses the results from the first single short coil test and from the first short quadrupole model test. Remaining challenges and plans to address them are also presented and discussed.

  9. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

    DEFF Research Database (Denmark)

    Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent

    2017-01-01

    -coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...... of structural variants including many novel insertions and demonstrate how this variant catalogue enables further deciphering of known association mapping signals. We leverage the assemblies to provide 100 completely resolved major histocompatibility complex haplotypes and to resolve major parts of the Y...

  10. Measurement of neutron energy spectra from 15 to 150 MeV using stacked liquid scintillators

    CERN Document Server

    Buffler, A; Allie, M S; Binns, P J; Dangendorf, V; Langen, K M; Nolte, R; Schuhmacher, H

    2002-01-01

    A multiple liquid scintillator system for measuring the energy spectrum of a neutron beam in the range 15-150 MeV is described. Two or more slabs of NE213 scintillator (13x13x7 cm sup 3) are stacked behind one-another and only events in which a neutron interacts in the upstream scintillator are analysed. The system is designed to minimise the escape of forward recoil protons from the detecting media. Test measurements and Monte Carlo simulations of the detector response to quasi-monoenergetic neutron beams of energies 62.5 and 97.5 MeV are presented.

  11. A 150 m/22.5 Gbaud PAM4-based FSO link

    Science.gov (United States)

    Li, Chung-Yi; Tsai, Wen-Shing

    2017-06-01

    A 22.5 Gbaud four-level pulse amplitude modulation (PAM4) signal applied to free-space optical link was experimentally tested using a 3 dB laser at a bandwidth of 10 GHz to directly modulate the 22.5 Gbaud PAM4 signal via injection-locked technology. Through the design of pre-compensation and equalizer for signal quality improvement, a successful transmission of 150 m in free space was achieved with good real-time bit error rate performance and clear eye diagrams (three independent eye diagrams).

  12. circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.

    Science.gov (United States)

    Luan, Junjun; Jiao, Congcong; Kong, Weiwei; Fu, Jingqi; Qu, Wei; Chen, Ying; Zhu, Xinwang; Zeng, Yu; Guo, Guangying; Qi, Huimeng; Yao, Li; Pi, Jingbo; Wang, Lining; Zhou, Hua

    2018-03-02

    Circular RNAs (circRNAs) participate in the pathogenesis of various diseases by sponging microRNAs (miRs). However, the roles of circRNAs remain unreported in glomerular diseases. We previously reported that miR-150 positively correlated with renal chronicity index in patients with lupus nephritis (LN). We aimed to investigate renal circRNA profiling and the interaction between circRNAs and miR-150 in LN patients. Six renal biopsies from untreated female patients with LN class IV and five normal kidney tissues from urology patients were used for circRNA sequencing. 171 circRNAs with 2-fold differential expression were identified in LN compared with normal control. Ten selected circRNAs were validated by real-time qPCR, and seven circRNAs showed the same significant increases as the sequencing results. circHLA-C positively correlated with proteinuria (R = 0.92, p 150 decreased 66% in LN compared with normal control (p 150 was regulated by circHLA-C and displayed one perfect match seed between circHLA-C and miR-150. The renal miR-150 showed a tendency of negative correlation with circHLA-C in LN patients. In conclusion, circHLA-C may play an important role in the pathogenesis of lupus nephritis by sponging miR-150. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  13. Constitutive expression of microRNA-150 in mammary epithelium suppresses secretory activation and impairs de novo lipogenesis.

    Science.gov (United States)

    Heinz, Richard E; Rudolph, Michael C; Ramanathan, Palani; Spoelstra, Nicole S; Butterfield, Kiel T; Webb, Patricia G; Babbs, Beatrice L; Gao, Hongwei; Chen, Shang; Gordon, Michael A; Anderson, Steve M; Neville, Margaret C; Gu, Haihua; Richer, Jennifer K

    2016-11-15

    Profiling of RNA from mouse mammary epithelial cells (MECs) isolated on pregnancy day (P)14 and lactation day (L)2 revealed that the majority of differentially expressed microRNA declined precipitously between late pregnancy and lactation. The decline in miR-150, which exhibited the greatest fold-decrease, was verified quantitatively and qualitatively. To test the hypothesis that the decline in miR-150 is crucial for lactation, MEC-specific constitutive miR-150 was achieved by crossing ROSA26-lox-STOP-lox-miR-150 mice with WAP-driven Cre recombinase mice. Both biological and foster pups nursed by bitransgenic dams exhibited a dramatic decrease in survival compared with offspring nursed by littermate control dams. Protein products of predicted miR-150 targets Fasn, Olah, Acaca, and Stat5B were significantly suppressed in MECs of bitransgenic mice with constitutive miR-150 expression as compared with control mice at L2. Lipid profiling revealed a significant reduction in fatty acids synthesized by the de novo pathway in L2 MECs of bitransgenic versus control mice. Collectively, these data support the hypothesis that a synchronized decrease in miRNAs, such as miR-150, at late pregnancy serves to allow translation of targets crucial for lactation. © 2016. Published by The Company of Biologists Ltd.

  14. Should All Shoulder Dislocations be Closed Reduced? Assessment of Risk of Iatrogenic Injury in 150 Patients

    Science.gov (United States)

    Solovyova, Olga; Shakked, Rachel

    2017-01-01

    Abstract Aims The purpose of this study was to determine if there was an association between iatrogenic fractures and closed reduction of shoulder dislocations. Patients and Methods In a retrospective case series, 150 consecutive patients with acute first time shoulder dislocations were evaluated. Patient demographics, direction of dislocation, associated injuries, reduction methods, number of attempts, and type of anesthesia/analgesia were determined. Pre- and post-reduction radiographs and medical record were reviewed to identify the presence of proximal humerus fractures. Results There were thirty nine fracture-dislocations (26%) of the proximal humerus. Eight patients (5%) failed reduction on initial attempt. Four of these (3%) were unable to be reduced in the emergency room and were taken to OR for reduction. There was no statistically significant difference in reduction maneuver or type of anesthesia/analgesia used when comparing fracture-dislocations to dislocations only (pdislocation are extremely rare. None were identified in this review of 150 patients. We believe that closed reduction is safe even in the setting of fracture dislocations. PMID:28852334

  15. Pierre Elliott Trudeau and bill C-150: a rational approach to homosexual acts, 1968-69.

    Science.gov (United States)

    Chambers, Stuart

    2010-01-01

    Between 1968 and 1969, Canadian Prime Minister Pierre Elliott Trudeau sparked a controversy surrounding his liberal government's passage of Bill C-150, which not only decriminalized homosexual acts between consenting adults in private, but also polarized supporters of natural law and positive law. What tipped the balance in favor of a more secular analysis of homosexuality? In the post-World War II era, three events were particularly relevant to the successful passage of Bill C-150: the Kinsey (1948) studies, Britain's Wolfenden Report (1957), and the Supreme Court of Canada case Klippert v. The Queen (des Rivieres & Shipley, 1967). However, the Liberals, Conservatives, Social Credit Party, and the Ralliement Creditistes were all influenced by the social construction of inversion, openly expressing a Judeo-Christian natural law bias during Debates of the House of Commons (1968-69). Nonetheless, it was the Liberals that were identified as forces within Canadian politics that could separate legalism from moralism, even while retaining personal moral stances against homosexuals. It is this paradox that is often forgotten when discussing liberal policy in Canada during the late 1960s.

  16. Numerical Investigation on Performance of Coal Gasifier of 150kW under Various Injection Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hyeongyeong; Suh, Jaeseung [Hannam Univ., Daejeon (Korea, Republic of); Lho, Taihyeop [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    Integrated coal gasification combined cycle (IGCC) has gained a lot of interest because they can produce cleaner gaseous fuels such as hydrogen, carbon monoxide and methane. This study focuses on the 150kW gasifier which is used in the National Fusion Research Institute (NFRI) plant. It is a fusion plasma technology to existing coal gasifier for better efficiency of low-carbon fuels. The cold gas is generated by reacting oxidants to coal with plasma technology of high temperature. The purpose of this study is to get the highest cold gas efficiency varied according to oxidant/coal injection amount, location and feeding gas. It is considerably complicated and expensive that cold gas efficiency is experimentally compared for all cases. It is possible to predict flow patterns, tracks of particles, combustion characteristics, temperature distributions and chemical distributions using the commercial CFD solver ANSYS/FLUENT. This study has numerical investigation for the phenomena of coal gasification for coal gasifier of 150kW at various operating conditions. The results are summarized in table 6. The air as feeding gas is more efficient than carbon dioxide, and the amount of coal that is important to find the appropriate value for the capacity of the gasifier than strictly greater.

  17. Role of p -induced population of medium-mass (A ˜150 ) neutron-rich nuclei

    Science.gov (United States)

    Banerjee, D.; Saha, A.; Bhattacharjee, T.; Guin, R.; Das, S. K.; Das, P.; Pandit, Deepak; Mukherjee, A.; Chowdhury, A.; Bhattacharya, Soumik; Das Gupta, S.; Bhattacharyya, S.; Mukhopadhyay, P.; Banerjee, S. R.

    2015-02-01

    Excitation functions were measured by stacked-foil activation technique for the 150Nd(p ,x p y n ) reaction using a 97.65% enriched 150Nd target. Measurement up to ˜50 % above barrier and down to 18% below the barrier was performed using a proton beam energy (Ep) of 7-15 MeV from the VECC Cyclotron. The yield of suitable γ rays emitted following the decay of relevant evaporation residues was determined using a 50% high-purity germanium (HPGe) detector. The (p ,n ) cross section was found to follow the expected trend with a maximum value of 63.7(4.9) mb at Ep˜8.6 MeV. The (p ,2 n ) cross section gradually increased with Ep and had a maximum contribution to the total reaction cross section after Ep˜9.0 MeV. The (p,p 'n ) reaction channel also showed a reasonable yield with a threshold of Ep˜12.0 MeV. The experimental data were corroborated with statistical model calculations using different codes, viz., cascade, alice/91, and empire3.1. All the calculations using a suitable set of global parameters could reproduce the excitation function fairly well in the present energy range.

  18. Role of p-induced population of medium mass(A $\\sim$ 150) neutron rich nuclei

    CERN Document Server

    Banerjee, D; Bhattacharjee, T; Guin, R; Das, S K; Das, P; Pandit, Deepak; Mukherjee, A; Chowdhury, A; Bhattacharya, Soumik; Gupta, S Das; Bhattacharyya, S; Mukhopadhyay, P; Banerjee, S R

    2014-01-01

    Excitation functions were measured by stacked-foil activation technique for the $^{150}$Nd(p, xpyn) reaction using 97.65$%$ enriched $^{150}$Nd target. Measurement up to $\\sim$50$%$ above barrier and down to 18$%$ below the barrier was performed using proton beam energy (E$_p$) of 7 - 15 MeV from VECC Cyclotron. The yield of suitable $\\gamma$ rays emitted following the decay of relevant evaporation residues was determined using a 50$%$ High Purity Germanium (HPGe) detector.(p,n) cross section was found to follow the expected trend with a maximum value of 63.7(4.9)mb at E$_p$ $\\sim$ 8.6 MeV. (p,2n) cross section gradually increased with E$_p$ and had maximum contribution to the total reaction cross section after E$_p$ $\\sim$ 9.0 MeV. (p, p$^{\\prime}$n) reaction channel also showed a reasonable yield with a threshold of E$_p$ $\\sim$ 12.0 MeV. The experimental data were corroborated with statistical model calculations using different codes, viz., CASCADE, ALICE/91 and EMPIRE3.1. All the calculations using a suit...

  19. SPS Injection and Beam Quality for LHC Heavy Ions With 150 ns Kicker Rise Time

    CERN Document Server

    Goddard, Brennan; Ducimetière, Laurent; Kotzian, Gerd; Uythoven, Jan; Velotti, Francesco

    2016-01-01

    As part of the LHC Injectors Upgrade project for LHC heavy ions, the SPS injection kicker system rise time needs reduction below its present 225 ns. One technically challenging option under consideration is the addition of fast Pulse Forming Lines in parallel to the existing Pulse Forming Networks for the 12 kicker magnets MKP-S, targeting a system field rise time of 100 ns. An alternative option is to optimise the system to approach the existing individual magnet field rise time (2-98%) of 150 ns. This would still significantly increase the number of colliding bunches in LHC while minimising the cost and effort of the system upgrade. The observed characteristics of the present system are described, compared to the expected system rise time, together with results of simulations and measurements with 175 and 150 ns injection batch spacing. The expected beam quality at injection into LHC is quantified, with the emittance growth and simulated tail population taking into account expected jitter and synchronisatio...

  20. Spin wave eigenmodes in single and coupled sub-150 nm rectangular permalloy dots

    Energy Technology Data Exchange (ETDEWEB)

    Carlotti, G., E-mail: giovanni.carlotti@fisica.unipg.it; Madami, M. [Dipartimento di Fisica e Geologia, Università di Perugia, Perugia (Italy); Tacchi, S. [Istituto Officina dei Materiali del CNR (CNR-IOM), Dipartimento di Fisica e Geologia, Perugia (Italy); Gubbiotti, G.; Dey, H.; Csaba, G.; Porod, W. [Center for Nano Science and Technology, Department of Electrical Engineering, University of Notre Dame, Notre Dame, Indiana 46556 (United States)

    2015-05-07

    We present the results of a Brillouin light scattering investigation of thermally excited spin wave eigenmodes in square arrays of either isolated rectangular dots of permalloy or twins of dipolarly coupled elements, placed side-by-side or head-to-tail. The nanodots, fabricated by e-beam lithography and lift-off, are 20 nm thick and have the major size D in the range between 90 nm and 150 nm. The experimental spectra show the presence of two main peaks, corresponding to modes localized either at the edges or in the center of the dots. Their frequency dependence on the dot size and on the interaction with adjacent elements has been measured and successfully interpreted on the basis of dynamical micromagnetic simulations. The latter enabled us also to describe the spatial profile of the eigenmodes, putting in evidence the effects induced by the dipolar interaction between coupled dots. In particular, in twinned dots the demagnetizing field is appreciably modified in proximity of the “internal edges” if compared to the “external” ones, leading to a splitting of the edge mode. These results can be relevant for the exploitation of sub-150 nm magnetic dots in new applications, such as magnonic metamaterials, bit-patterned storage media, and nano-magnetic logic devices.

  1. Interfacial (Fiber-matrix) Properties of High-strength Mortar (150 MPa) from Fiber Pullout

    DEFF Research Database (Denmark)

    Shannag, M.J.; Brincker, Rune; Hansen, Will

    1996-01-01

     The steel fiber-matrix properties of high-strength mortar (150 MPa), such as DSP (densified small particle), are obtained and compared to an ordinary strength mortar (40 MPa) using a specially designed fiber pullout apparatus. A new method for estimating the debonding energy of the interfacial z...... DSP mortar has significantly improved interfacial properties compared to ordinary strength mortar. These results are important in the understanding of the role of steel fibers in improving the tensile properties of high-strength, brittle, cement-matrix composites....... The steel fiber-matrix properties of high-strength mortar (150 MPa), such as DSP (densified small particle), are obtained and compared to an ordinary strength mortar (40 MPa) using a specially designed fiber pullout apparatus. A new method for estimating the debonding energy of the interfacial...... zone from the experimental pullout curve is presented. The method is used to separate the areas under the pullout curve corresponding to debonding and friction. The predictions are compared to other methods in the literature. The proposed method seems to provide less variations in the results. The high-strength...

  2. A comparative bibliometric analysis of the top 150 cited papers in hypospadiology (1945-2013).

    Science.gov (United States)

    O'Kelly, F; Nason, G J; McLoughlin, L C; Flood, H D; Thornhill, J A

    2015-04-01

    Hypospadias, the most common congenital malformation of the penis, is characterized by an abnormal ventral opening of the urethral meatus, abnormal ventral curvature of the penis, and an abnormal distribution of the foreskin around the glans, with a ventrally-deficient hooded foreskin, and has been described in modern peer-reviewed literature since Noble's description in 1853. A dramatic increase in the literature on hypospadiology has focused on two main topics: The aetiology of the condition including molecular mechanisms and environmental influences, as well as surgical techniques to repair the defect, however there have been a number of facets of research stemming from this poorly understood condition in a developing subspecialty (Figure). The majority of these publications focus on the evolution of surgical technique and management. Urethral reconstruction should offer the ability to stand to urinate and combine a satisfactory cosmetic result. The tubularized incised plate repair, popularized by Snodgrass et al., and the Mathieu repair, have been the mainstay for distal hypospadias, however, there have still been a large number of well-described techniques, with no consensus as to the ideal method of repair, some of which is attributed to non-uniform standards of reporting outcomes. There is also no standard objective means to qualitatively assess the importance of each of these contributions. The objective of this study was to determine the top 150 peer-reviewed articles in the field of hypospadiology by way of citation analysis as a means to determine the importance/relevance of each contribution throughout 8 decades of research. A cited reference search was carried out for indexed citations within Web of Science™ Core Collection. The top 150 indexed cited articles containing the topic "hypospadias" in specific subject categories were compiled using a component of Science Citation Index command. References were then evaluated, and analysed across a number

  3. Spectroscopic analysis of lithium terbium tetrafluoride

    DEFF Research Database (Denmark)

    Christensen, H.P.

    1978-01-01

    . The rare-earth site in LiTbF4 possesses S4 symmetry, which allows six crystal-field parameters. ζ and the six Bim were varied to obtain the best agreement with the experimentally observed levels. Keeping F2=434 cm-1 fixed, a fit with a standard deviation of 12 cm-1 was obtained at 10 K with the following...... were calculated by diagonalizing an effective spin-orbit and crystal-field Hamiltonian in an LS basis. H=Σλi(L→·S→)i+ΣαiΣBimOim, where the parameters λi are functions of the spin-orbit parameter ζ and the Slater parameter F2. The Oim and αi are Racah operators and reduced matrix elements, respectively...

  4. Inelastic critical scattering of neutrons from terbium

    DEFF Research Database (Denmark)

    Als-Nielsen, Jens Aage; Dietrich, O.W.; Marshall, W.

    1967-01-01

    We have measured the inelasticity of the critical neutron scattering in Tb above the Néel temperature. The results show that dynamical slowing down of fluctuations does occur at a second order phase transition.......We have measured the inelasticity of the critical neutron scattering in Tb above the Néel temperature. The results show that dynamical slowing down of fluctuations does occur at a second order phase transition....

  5. THE EFFICIENCY OF USING THE MEDICATION COMBING 150 MG OF ISONIAZID , 375 MG OF PYRAZINA MIDE , 150 MG OF RI FAMPICIN IN THE TREATMEN T OF RESPIRATOR Y TUBERCULOSIS IN CHILDREN

    Directory of Open Access Journals (Sweden)

    Yu. E. Ovchinnikovа

    2017-01-01

    Full Text Available The main problem for treatment of children with various manifestations of tuberculosis is the lack of pediatric dosages of anti-tuberculosis drugs. Considering the current problems when providing treatment it is important to use combined medications with fixed pediatric dosages, which would significantly help to simplify the administration of medications and to relieve the psychological, emotional and physical load when taking a significant number of drugs.Goal of the study: to define the efficiency of using fixed doses of the medication combing 150 mg of isoniazid, 375 mg of pyrazinamide, 150 mg of rifampicin. Clinical, X-ray and laboratory rates were assessed during treatment of 73 children suffering from respiratory tuberculosis, of them 34 children were treated by the medication combing 150 mg of isoniazid, 375 mg of pyrazinamide, 150 mg of rifampicin plus ethambutol, and the other children were treated by the standard chemotherapy. The opportunity of effective use of the medication combining 150 mg of isoniazid, 375 mg of pyrazinamide, 150 mg of rifampicin in children was confirmed by positive results by the completion of the intensive phase of treatment as well as the continuation phase and minimization of adverse reactions during treatment. The combination of active components of the medication and doses is convenient for use, allow conducting directly observed treatment and enhancing the efficiency of chemotherapy.

  6. Clinical and immunological characteristics of 150 systemic lupus erythematosus patients in Jamaica: a comparative analysis.

    Science.gov (United States)

    Maloney, K C; Ferguson, T S; Stewart, H D; Myers, A A; De Ceulaer, K

    2017-11-01

    Background Epidemiological studies in systemic lupus erythematosus have been reported in the literature in many countries and ethnic groups. Although systemic lupus erythematosus in Jamaica has been described in the past, there has not been a detailed evaluation of systemic lupus erythematosus patients in urban Jamaica, a largely Afro-Caribbean population. The goal of this study was to describe the clinical features, particularly disease activity, damage index and immunological features, of 150 systemic lupus erythematosus subjects. Methods 150 adult patients (≥18 years) followed in rheumatology clinic at a tertiary rheumatology hospital centre (one of two of the major public referral centres in Jamaica) and the private rheumatology offices in urban Jamaica who fulfilled Systemic Lupus International Collaborating Clinics (SLICC) criteria were included. Data were collected by detailed clinical interview and examination and laboratory investigations. Hence demographics, SLICC criteria, immunological profile, systemic lupus erythematosus disease activity index 2000 (SLEDAI-2K) and SLICC/American College of Rheumatology (ACR) damage index (SDI) were documented. Results Of the 150 patients, 145 (96.7%) were female and five (3.3%) were male. The mean age at systemic lupus erythematosus onset was 33.2 ± 10.9. Mean disease duration was 11.3 ± 8.6 years. The most prevalent clinical SLICC criteria were musculoskeletal, with 141 (94%) of subjects experiencing arthralgia/arthritis, followed by mucocutaneous manifestations of alopecia 103 (68.7%) and malar rash 46 (30.7%), discoid rash 45 (30%) and photosensitivity 40 (26.7%). Lupus nephritis (biopsy proven) occurred in 42 (28%) subjects and 25 (16.7%) met SLICC diagnostic criteria with only positive antinuclear antibodies/dsDNA antibodies and lupus nephritis on renal biopsy. The most common laboratory SLICC criteria were positive antinuclear antibodies 136 (90.7%) followed by anti-dsDNA antibodies 95 (63.3%) and

  7. Muusikamaailm : Barenboimi festival Berliinis. Lihavõtteaegu Luzernis, Viinis, Salzburgis, Hamburgis ja Londonis. Soome ooper 150 / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2002-01-01

    Wagneri ooperite "Festtage" Berliinis. Lihavõtteaegu toimunud kontsertidest Luzernis, Viinis, Salzburgis, Hamburgis ja Londonis. Soome ooperiloo esimesest ooperist Fredrik Paciuse "Kuningas Karli jahiretk" sünnist on möödunud 150

  8. Magnet Design of the 150 mm Aperture Low-β Quadrupoles for the High Luminosity LHC

    CERN Document Server

    Ferracin, P; Anerella, M; Borgnolutti, F; Bossert, R; Cheng, D; Dietderich, D R; Felice, H; Ghosh , A; Godeke, A; Izquierdo Bermudez, S; Fessia, P; Krave, S; Juchno, M; Perez, J C; Oberli, L; Sabbi, G; Todesco, E; Yu, M

    2014-01-01

    The High Luminosity LHC (HL-LHC) project is aimed at studying and implementing the necessary changes in the LHC to increase its luminosity by a factor five. Among the magnets that will be upgraded are the 16 superconducting low-β quadrupoles placed around the two high luminosity interaction regions (ATLAS and CMS experiments). In the current baseline scenario, these quadrupole magnets will have to generate a gradient of 140 T/m in a coil aperture of 150 mm. The resulting conductor peak field of more than 12 T will require the use of Nb3Sn superconducting coils. We present in this paper the HL-LHC low-β quadrupole design, based on the experience gathered by the US LARP program, and, in particular, we describe the support structure components to pre-load the coils, withstand the electro-magnetic forces, provide alignment and LHe containment, and integrate the cold mass in the LHC IRs.

  9. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

    DEFF Research Database (Denmark)

    Maretty, Lasse; Jensen, Jacob Malte; Petersen, Bent

    2017-01-01

    or by performing local assembly. However, these approaches are biased against discovery of structural variants and variation in the more complex parts of the genome. Hence, large-scale de novo assembly is needed. Here we show that it is possible to construct excellent de novo assemblies from high......-coverage sequencing with mate-pair libraries extending up to 20 kilobases. We report de novo assemblies of 150 individuals (50 trios) from the GenomeDenmark project. The quality of these assemblies is similar to those obtained using the more expensive long-read technology. We use the assemblies to identify a rich set...... of structural variants including many novel insertions and demonstrate how this variant catalogue enables further deciphering of known association mapping signals. We leverage the assemblies to provide 100 completely resolved major histocompatibility complex haplotypes and to resolve major parts of the Y...

  10. Study of the radiative strength function in /sup 148,150/Sm

    Energy Technology Data Exchange (ETDEWEB)

    Becvar, F.; Montero-Cabrera, M.E.; Rigol, J.; Telezhnikov, S.A.; Hiep, H.T.

    1987-07-01

    The spectra of ..gamma.. rays accompanying neutron capture by the nuclei /sup 147//sup ,//sup 149/Sm is isolated resonances have been measured by the time-of-flight method in the IBR-30 reactor. Absolute intensities have been obtained for a number of transitions. From a combination of the results of the present work and published data we have determined the radiative strength function of the nuclei /sup 148/Sm and /sup 150/Sm for E1 transitions in the ..gamma..-ray energy region 5--7.5 MeV. The values obtained are 2.8 and 1.7 times smaller than the respective values expected from extrapolation of the Lorentz curves of the giant electric dipole resonance. An analysis of the behavior of the radiative strength function of nuclei with A = 148--157 is carried out.

  11. Characteristics of a piezoresistive accelerometer in shock environments up to 150,000 G

    Energy Technology Data Exchange (ETDEWEB)

    Bateman, V.I.; Davie, N.T.; Brown, F.A.

    1995-03-01

    The characteristics of a piezoresistive accelerometer in shock environments are being studied at Sandia National Laboratories in the Mechanical Shock Testing Laboratory. A Hopkinson bar capability has been developed to extend our undemanding of the piezoresistive accelerometer, in two mechanical configurations, in the high frequency, high shock environments where measurements are being made. Two different Hopkinson bar materials are being used: Titanium and beryllium The in-axis performance of the piezoresistive accelerometer for frequencies of dc-10 kHz and shock magnitudes of up to 150,000 g as determined from measurements with a titanium Hopkinson bar are presented. The beryllium Hopkinson bar configuration is described. Preliminary in-axis characteristics of the piezoresistive accelerometer at a nominal shock level of 50,000 g for a frequency range of DC-30 kHz determined from the beryllium bar are presented.

  12. Radiation hard pixel sensors using high-resistive wafers in a 150 nm CMOS processing line

    Science.gov (United States)

    Pohl, D.-L.; Hemperek, T.; Caicedo, I.; Gonella, L.; Hügging, F.; Janssen, J.; Krüger, H.; Macchiolo, A.; Owtscharenko, N.; Vigani, L.; Wermes, N.

    2017-06-01

    Pixel sensors using 8'' CMOS processing technology have been designed and characterized offering the benefits of industrial sensor fabrication, including large wafers, high throughput and yield, as well as low cost. The pixel sensors are produced using a 150 nm CMOS technology offered by LFoundry in Avezzano. The technology provides multiple metal and polysilicon layers, as well as metal-insulator-metal capacitors that can be employed for AC-coupling and redistribution layers. Several prototypes were fabricated and are characterized with minimum ionizing particles before and after irradiation to fluences up to 1.1 × 1015 neq cm-2. The CMOS-fabricated sensors perform equally well as standard pixel sensors in terms of noise and hit detection efficiency. AC-coupled sensors even reach 100% hit efficiency in a 3.2 GeV electron beam before irradiation.

  13. Great moments in kinetic theory: 150 years of Maxwell’s (other) equations

    Science.gov (United States)

    Robson, Robert E.; Mehrling, Timon J.; Osterhoff, Jens

    2017-11-01

    In 1867, just two years after laying the foundations of electromagnetism, J. Clerk Maxwell presented a fundamental paper on kinetic gas theory, in which he described the evolution of the gas in terms of certain ‘moments’ of its velocity distribution function. This inspired Ludwig Boltzmann to formulate his famous kinetic equation, from which followed the H-theorem and the connection with entropy. On the occasion of the 150th anniversary of publication of Maxwell's paper, we review the Maxwell–Boltzmann formalism and discuss how its generality and adaptability enable it to play a key role in describing the behaviour of a variety of systems of current interest, in both gaseous and condensed matter, and in modern-day physics and technologies which Maxwell and Boltzmann could not possibly have foreseen. In particular, we illustrate the relevance and applicability of Maxwell's formalism to the dynamic field of plasma-wakefield acceleration.

  14. Organic carbon sequestration in coastal sediments across the Baltic Sea over the last 150 years

    Science.gov (United States)

    Ryves, David; Lewis, Jonathan; Rasmussen, Peter; Weckström, Kaarina; Andrén, Elinor; Clarke, Annemarie; Andersen, Thorbjørn; Yang, Handong; Hietanen, Susanah; Jilbert, Tom; Aigars, Juris; Anderson, N. John

    2017-04-01

    Coastal areas are extremely vulnerable to impacts from changing marine conditions, which are increasingly being driven by human activity (e.g. nutrient cycling, salinity, hydrography, sea level, climate change). Recent research into the complex and dynamic cycling of carbon in many increasingly nutrient-enriched coastal systems has suggested that they have switched from being net C sources to net C sinks over the last 150 years. This study seeks to explore carbon sequestration rates over the last 150 years from several key regions across the coastal Baltic Sea by synthesising organic carbon (OC) inventories from multiple well-dated sedimentary records from Baltic coasts. Such data will provide insight into long-term coastal change and how terrestrial human impact is influencing the ecology and biogeochemistry of the Baltic Sea. To examine past and present rates of carbon burial in key coastal areas of the Baltic Sea, a synthesis of 30-40 sediment cores from across the Baltic Sea is presented here from Baltic Denmark, Germany, Latvia, western Sweden and southern Finland, and are primarily from near-shore and shallow fjord/estuarine sites. The majority of sites span the last 100-150 years and the majority (>75%) are independently dated using 210Pb. Unsupported 210Pb inventories also allow raw sedimentation rates to be corrected for sediment focussing, permitting regionally reliable estimates of OC accumulation rates to be calculated and provide a plausible basis for upscaling OC accumulation rates within these key regions of the Baltic. Preliminary data analyses suggest a major step-change in system behaviour during the 20th century following low, stable ( 10 g OC m-2 yr-1 focussing corrected, OCFC) rates pre-1900. The initial rise in burial rates occurs early in the 1900s though is punctuated by a slight fall during the 1930s/1940s. After 1950, burial rates dramatically rise (consistently up to 45 g OCFC m-2 yr-1; 4 x pre-1900 rates), a pattern which is repeated

  15. Co-firing straw and coal in a 150-MWe utility boiler: in situ measurements

    DEFF Research Database (Denmark)

    Hansen, P. F.B.; Andersen, Karin Hedebo; Wieck-Hansen, K.

    1998-01-01

    A 2-year demonstration program is carried out by the Danish utility I/S Midtkraft at a 150-MWe PF-boiler unit reconstructed for co-firing straw and coal. As a part of the demonstration program, a comprehensive in situ measurement campaign was conducted during the spring of 1996 in collaboration...... with the Technical University of Denmark. Six sample positions have been established between the upper part of the furnace and the economizer. The campaign included in situ sampling of deposits on water/air-cooled probes, sampling of fly ash, flue gas and gas phase alkali metal compounds, and aerosols as well...... as temperature measurements. Material balance closures were carried out at all operating conditions. The experimental data was evaluated together with researchers from the Technical University of Denmark and the results were stored in a data base program developed under the CHEC-research program to predict...

  16. T/R Multi-Chip MMIC Modules for 150 GHz

    Science.gov (United States)

    Samoska, Lorene A.; Pukala, David M.; Soria, Mary M.; Sadowy, Gregory A.

    2009-01-01

    Modules containing multiple monolithic microwave integrated-circuit (MMIC) chips have been built as prototypes of transmitting/receiving (T/R) modules for millimeter-wavelength radar systems, including phased-array radar systems to be used for diverse purposes that could include guidance and avoidance of hazards for landing spacecraft, imaging systems for detecting hidden weapons, and hazard-avoidance systems for automobiles. Whereas prior landing radar systems have operated at frequencies around 35 GHz, the integrated circuits in this module operate in a frequency band centered at about 150 GHz. The higher frequency (and, hence, shorter wavelength), is expected to make it possible to obtain finer spatial resolution while also using smaller antennas and thereby reducing the sizes and masses of the affected systems.

  17. Fabrication and Analysis of 150 mm Aperture Nb3Sn LARP MQXF Coils

    CERN Document Server

    Holik, E F; Anerella, M; Bossert, R; Cavanna, E; Cheng, D; Dietderich, D R; Ferracin, P; Ghosh, A K; Izquierdo Bermudez, S; Krave, S; Nobrega, A; Perez, J C; Pong, I; Rochepault; Sabbi, G L; Schmalzle, J; Yu, M

    2016-01-01

    The US LHC Accelerator Research Program (LARP) and CERN are combining efforts for the HiLumi-LHC upgrade to design and fabricate 150 mm aperture, interaction region quadrupoles with a nominal gradient of 130 T/m using Nb3Sn. To successfully produce the necessary long MQXF triplets, the HiLumi-LHC collaboration is systematically reducing risk and design modification by heavily relying upon the experience gained from the successful 120 mm aperture LARP HQ program. First generation MQXF short (MQXFS) coils were predominately a scaling up of the HQ quadrupole design allowing comparable cable expansion during Nb3Sn formation heat treatment and increased insulation fraction for electrical robustness. A total of 13 first generation MQXFS coils were fabricated between LARP and CERN. Systematic differences in coil size, coil alignment symmetry, and coil length contraction during heat treatment are observed and likely due to slight variances in tooling and insulation/cable systems. Analysis of coil cross sections indic...

  18. Santander, de local a internacional: 150 años de historia

    OpenAIRE

    Pablo Martín Aceña

    2008-01-01

    El artículo resume la trayectoria del Banco Santander desde su creación en 1857 hasta el año 2007, año en el que se cumple su 150 aniversario. Se muestra cómo ha sido el proceso de transformación de la entidad y cómo se ha producido su ascenso a través de la escala geográfica: de sociedad de crédito local a banco regional y después a banco nacional hasta alcanzar su actual posición de líder en el sistema financiero mundial. El Santander ha crecido mediante la expansión de sus acti...

  19. The evolution of America's scientific advancements in dentistry in the past 150 years.

    Science.gov (United States)

    Gutmann, James L

    2009-09-01

    During the last 150 years, dentistry in the United States faced many challenges as it developed its scientific foundation. In the latter part of the 19th century, clinical practice was driven by empirical evidence, and the first few decades of the 20th century set the stage for America's scientific evolution of dentistry. Seminal developments in America's contribution to science in dentistry and oral health included the 1926 Carnegie Foundation for the Advancement of Teaching report and the vision of William J. Gies; the development of scientific dental journals; the role of immigrant dental scientists from Europe and oral biology as a discipline; and the establishment of the National Institute of Dental Research in 1948. Due in large part to America's contribution to dental science and practice, we are at the brink of a transformation that may expand the role of the dental profession dramatically and improve the oral health of people throughout the world.

  20. Psalm 150 according to the Septuagint: integrating translation and tradition criticism into modern Septuagint exegesis

    Directory of Open Access Journals (Sweden)

    Evangelia G Dafni

    2006-09-01

    Full Text Available The attempt to detect� Theology in the linguistic deviations and divergencies of the Septuagint (LXX with the Massoretic Text (MT, presupposes the use of certain exegetical methods. Of course, this implies methods to be used by the modern Septuagint scholar and not the hypothetical translation technique(s used by the LXX-translators. Therefore, I suggest� the scholar should integrate the historical critical method � in a balanced manner, without the incriminating questioning of long outdated historicism - into the modern LXX-exegesis. In this way, I think, we have the opportunity to verify or falsify hypothetical exegetical practices probably used by the LXX-translators and to discover where we are really able to talk about genuine� Theology in the LXX � in contrast to the MT.� The LXX-Psalm 150, in comparison to other related Old Testament texts, was chosen to exemplify this suggestion.

  1. How the Sun Knocks Out My Cell Phone from 150 Million Kilometers Away

    Science.gov (United States)

    Ladbury, Ray

    2014-01-01

    Large solar particle events (SPE) threaten many elements of critical infrastructure. A 2013 study by Lloyds of London and Atmospheric and Environmental Research recently found that if a worst-case solar event like the 1859 Carrington Event struck our planet now, it could result on $0.6-$2.36 trillion in damages to the economy. In March 2014, researchers Y. D. Liu et al. revealed that just such an event had narrowly missed Earth in July 2012. The event was observed by the STEREO A spacecraft. In this presentation, we examine how the sun can pack such a punch from 150 million km away, the threats such solar particle events pose, their mechanisms and the efforts NASA and other space agencies are carrying out to understand and mitigate such risks.

  2. High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range.

    Science.gov (United States)

    Jayaraman, V; Cole, G D; Robertson, M; Uddin, A; Cable, A

    2012-07-05

    Microelectromechanical-systems-based vertical-cavity surface-emitting lasers (MEMS-VCSELs) capable of a 150 nm continuous tuning range near 1310 nm are demonstrated. These devices employ a thin optically pumped active region structure with large free-spectral range, which promotes wide and continuous tuning. To achieve VCSEL emission at 1310 nm, a wide-gain-bandwidth indium phosphide-based multiple quantum well active region is combined with a wide-bandwidth fully oxidised GaAs-based mirror through wafer bonding, with tuning enabled by a suspended dielectric top mirror. These devices are capable of being scanned over the entire tuning range at frequencies up to 500 kHz, making them ideal for applications such as swept source optical coherence tomography and high-speed transient spectroscopy.

  3. Full Scale Test on a 100km, 150kV AC Cable

    DEFF Research Database (Denmark)

    Faria da Silva, Filipe Farria; Wiechowski, W.; Bak, Claus Leth

    2010-01-01

    This paper presents some of the results obtained from the electrical measurements on a 99.7 km, 150 kV three-phase AC cable, connecting 215 MW offshore wind farm Horns Rev 2, located in Denmark west coast, to Denmark's 400 kV transmission network. The measurements were performed at nominal voltage......, but unusual in overhead lines. In this paper is made a characterization of the cable and the power transmission system in which the cable is installed, followed by a description of the measurement equipment and of the test setup/procedures. A theoretical explanation and presentation of different analysed...... phenomena is conducted. The cases analysed in this paper are: Zero-missing phenomenon, Ferranti effect, energisation transient, effect of the cable's connection in the busbar voltage and cable disconnection. For all the phenomena described in the paper measurement data are presented and it is verified...

  4. A search for faint high-redshift radio galaxy candidates at 150 MHz

    Science.gov (United States)

    Saxena, A.; Jagannathan, P.; Röttgering, H. J. A.; Best, P. N.; Intema, H. T.; Zhang, M.; Duncan, K. J.; Carilli, C. L.; Miley, G. K.

    2018-01-01

    Ultra-steep spectrum (USS) radio sources are good tracers of powerful radio galaxies at z > 2. Identification of even a single bright radio galaxy at z > 6 can be used to detect redshifted 21cm absorption due to neutral hydrogen in the intervening IGM. Here we describe a new sample of high-redshift radio galaxy (HzRG) candidates constructed from the TGSS ADR1 survey at 150 MHz. We employ USS selection (α ≤ -1.3) in ˜10000 square degrees, in combination with strict size selection and non-detections in all-sky optical and infrared surveys. We apply flux density cuts that probe a unique parameter space in flux density (50 < S150 < 200 mJy) to build a sample of 32 HzRG candidates. Follow-up Karl G. Jansky Very Large Array (VLA) observations at 1.4 GHz with an average beam size of 1.3 arcseconds (″) revealed ˜48% of sources to have a single radio component. P-band (370 MHz) imaging of 17 of these sources revealed a flattening radio SED for ten sources at low frequencies, which is expected from compact HzRGs. Two of our sources lie in fields where deeper multi-wavelength photometry and ancillary radio data are available and for one of these we find a best-fit photo-z of 4.8 ± 2.0. The other source has zphot = 1.4 ± 0.1 and a small angular size (3.7″), which could be associated with an obscured star forming galaxy or with a `dead' elliptical. One USS radio source not part of the HzRG sample but observed with the VLA nonetheless is revealed to be a candidate giant radio galaxy with a host galaxy photo-z of 1.8 ± 0.5, indicating a size of 875 kpc.

  5. Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques.

    Directory of Open Access Journals (Sweden)

    Rik L de Swart

    2007-11-01

    Full Text Available Measles virus (MV is hypothesized to enter the host by infecting epithelial cells of the respiratory tract, followed by viremia mediated by infected monocytes. However, neither of these cell types express signaling lymphocyte activation molecule (CD150, which has been identified as the receptor for wild-type MV. We have infected rhesus and cynomolgus macaques with a recombinant MV strain expressing enhanced green fluorescent protein (EGFP; thus bringing together the optimal animal model for measles and a virus that can be detected with unprecedented sensitivity. Blood samples and broncho-alveolar lavages were collected every 3 d, and necropsies were performed upon euthanasia 9 or 15 d after infection. EGFP production by MV-infected cells was visualized macroscopically, in both living and sacrificed animals, and microscopically by confocal microscopy and FACS analysis. At the peak of viremia, EGFP fluorescence was detected in skin, respiratory and digestive tract, but most intensely in all lymphoid tissues. B- and T-lymphocytes expressing CD150 were the major target cells for MV infection. Highest percentages (up to 30% of infected lymphocytes were detected in lymphoid tissues, and the virus preferentially targeted cells with a memory phenotype. Unexpectedly, circulating monocytes did not sustain productive MV infection. In peripheral tissues, large numbers of MV-infected CD11c+ MHC class-II+ myeloid dendritic cells were detected in conjunction with infected T-lymphocytes, suggesting transmission of MV between these cell types. Fluorescent imaging of MV infection in non-human primates demonstrated a crucial role for lymphocytes and dendritic cells in the pathogenesis of measles and measles-associated immunosuppression.

  6. 150 years of macronutrient change in unfertilized plant-soil ecosystems: Observations vs simulations

    Science.gov (United States)

    Davies, Jessica; Tipping, Ed; Whitmore, Andy

    2017-04-01

    Understanding changes in plant-soil carbon and nutrients using data alone is difficult due to the linkages between carbon, nitrogen and phosphorus cycles (C, N and P), and multiple changing long-term drivers (e.g. climate, land-use, and atmospheric N deposition). Hence, dynamic models are a vital tool for disentangling these drivers, helping us understand the dominant processes and drivers and predict future change. However, it is essential that models are tested against data if their outputs are to be concluded upon with confidence. Here, a simulation of C, N and P cycles using the N14CP model was compared with time-series observations of C, N and P in soils and biomass from the Rothamsted Research long-term experiments spanning 150 years, providing an unprecedented temporal integrated test of such a model. N14CP reproduced broad trends in soil organic matter (SOM) C, N and P, vegetation biomass and N and P leaching. Subsequently, the model was used to decouple the effects of land management and elevated nitrogen deposition in these experiments. Elevated N deposition over the last 150 years is shown to have increased net primary productivity (NPP) 4.5-fold and total carbon sequestration 5-fold at the Geescroft Wilderness experiment, which was re-wilded to woodland in 1886. In contrast, the model predicts that for cropped grassland conditions at the Park Grass site, elevated N deposition has very little effect on SOM, as increases in NPP are diverted from the soil. More broadly, these results suggest that N deposition is likely to have had a large effect on SOM and NPP in northern temperate and boreal semi-natural grasslands and forests. However, in cropped and grazed systems in the same region, whilst NPP may have been supported in part by elevated N deposition, declines in SOM may not have been appreciably counteracted by increased N availability.

  7. Effect of pre-equilibrium spin distribution on neutron induced {sup 150}Sm cross sections

    Energy Technology Data Exchange (ETDEWEB)

    Dashdorj, D.; Mitchell, G.E. [North Carolina State University, Raleigh, NC (United States); Dashdorj, D.; Becker, J.A.; Agvaanluvsan, U.; Wu, C.Y.; Younes, W. [Lawrence Livermore National Laboratory, Livermore, CA (United States); Kawano, T.; Chadwick, M.; Devlin, M.; Fotiades, N.; Nelson, R.O. [3 Los Alamos National Laboratory, Los Alamos, NM (United States); Mitchell, G.E. [Triangle Univ. Nuclear Laboratory, Durham, NC (United States); Cooper, J.R. [USEC Inc., Piketon, OH (United States); Garrett, P.E. [Guelph Univ., Ontario (Canada); Kunieda, S. [Japan Atomic Energy Agency, Tokai, Naka, Ibaraki (Japan)

    2008-07-01

    Prompt {gamma}-ray production cross section measurements were made as a function of incident neutron energy (E{sub n} = 1 to 35 MeV) on an enriched (95.6%) {sup 150}Sm sample. Energetic neutrons were delivered by the Los Alamos National Laboratory spallation neutron source. The prompt-reaction {gamma} rays were detected with the large-scale Compton-suppressed Germanium Array for Neutron Induced Excitations (GEANIE). Above En {approx} 8 MeV the pre-equilibrium reaction process dominates the inelastic reaction. The spin distribution transferred in pre-equilibrium neutron-induced reactions was calculated using the quantum mechanical theory of Feshbach, Kerman, and Koonin (FKK). These pre-equilibrium spin distributions were incorporated into the Hauser-Feshbach statistical reaction code GNASH and the {gamma}-ray production cross sections were calculated and compared with experimental data. Neutron inelastic scattering populates {sup 150}Sm excited states either by (1) forming the compound nucleus {sup 151}Sm{sup *} and decaying by neutron emission, or (2) by the incoming neutron transferring energy to create a particle-hole pair, and thus initiating the pre-equilibrium process. These two processes produce rather different spin distributions: the momentum transfer via the pre-equilibrium process tends to be smaller than in the compound reaction. This difference in the spin population has a significant impact on the {gamma}-ray de-excitation cascade and therefore in the partial {gamma}-ray cross sections. The difference in the calculated partial {gamma}-ray cross sections using spin distributions with and without pre-equilibrium effects was significant, e.g., for the 558-keV transition between 8{sup +} and 6{sup +} states the calculated partial {gamma}-ray production cross sections changed by 70% at E{sub n} equals 20 MeV with inclusion of the spin distribution of pre-equilibrium process. (authors)

  8. Effect of pre-equilibrium spin distribution on neutron induced 150Sm cross sections

    Energy Technology Data Exchange (ETDEWEB)

    Dashdorj, D; Kawano, T; Mitchell, G E; Becker, J A; Agvaanluvsan, U; Chadwick, M; Cooper, J; Devlin, M; Fotiades, N; Garrett, P E; Kunieda, S; Nelson, R O; Wu, C Y; Younes, W

    2007-04-16

    Prompt {gamma}-ray production cross section measurements were made as a function of incident neutron energy (En = 1 to 35 MeV) on an enriched (95.6%) {sup 150}Sm sample. Energetic neutrons were delivered by the Los Alamos National Laboratory spallation neutron source located at the Los Alamos Neutron Science Center (LANSCE) facility. The prompt-reaction {gamma} rays were detected with the large-scale Compton-suppressed Germanium Array for Neutron Induced Excitations (GEANIE). Above E{sub n} {approx} 8 MeV the pre-equilibrium reaction process dominates the inelastic reaction. The spin distribution transferred in pre-equilibrium neutron-induced reactions was calculated using the quantum mechanical theory of Feshbach, Kerman, and Koonin (FKK). These preequilibrium spin distributions were incorporated into the Hauser-Feshbach statistical reaction code GNASH and the {gamma}-ray production cross sections were calculated and compared with experimental data. Neutron inelastic scattering populates 150Sm excited states either by (1) forming the compound nucleus {sup 151}Sm* and decaying by neutron emission, or (2) by the incoming neutron transferring energy to create a particle-hole pair, and thus initiating the pre-equilibrium process. These two processes produce rather different spin distributions: the momentum transfer via the pre-equilibrium process tends to be smaller than in the compound reaction. This difference in the spin population has a significant impact on the {gamma}-ray de-excitation cascade and therefore in the partial {gamma}-ray cross sections. The difference in the partial {gamma}-ray cross sections using spin distributions with and without preequilibrium effects was significant, e.g., for the 558-keV transition between 8{sup +} and 6{sup +} states the calculated partial {gamma}-ray production cross sections changed by 70% at E{sub n} = 20 MeV with inclusion of the spin distribution of pre-equilibrium process.

  9. Alpha particle spectra in coincidence with normal and superdeformed states in {sup 150}Tb

    Energy Technology Data Exchange (ETDEWEB)

    Viesti, G.; Lunardon, M.; Bazzacco, D. [dell`Universita, Padova (Italy)]|[INFN, Padova (Italy)] [and others

    1996-12-31

    The study of correlations between particle evaporation from highly excited compound nuclei at large angular momenta and the states in the final evaporation residues (ER) is a field of investigation which has been opened, in the last years, with the advent of the new large {gamma}-ray arrays. It is now possible to correlate the evaporation spectra to various bands with shapes ranging from spherical to superdeformed (SD) in the same final nucleus. It is generally accepted that the particle evaporation from the compound nucleus is chaotic and that only in the near-yrast {gamma} cascade, where the feeding of different classes of states takes place, the ordered motion is restored. The sensitivity of the particle spectra on the feeding of specific states in the residual nuclei can be taken as an indication that additional degrees of freedom might be important in the evaporation process or that particular regions of the phase space open to the decay populate preferentially some selected structures in the final cold nucleus. This latter point is important for the understanding of the feeding mechanism of SD states. Several experiments performed so far did not find a clear dependence of the shapes of the particle spectra on the excited states having different deformations in the ER. For example, the proton spectra in coincidence with transitions in the SD bands of {sup 133}Nd and {sup 152}Dy nuclei were found to be similar to those in coincidence with transitions in the normal deformed (ND) bands. Alpha particles have been proposed since long as a sensitive probe of the deformation of the emitting nucleus. Results are presented here of an experiment in which the authors have measured the energy spectra of alpha particles associated with different classes of states (ND and SD) in the {sup 150}Tb nucleus populated in the reaction {sup 37}Cl({sup 120}Sn, {alpha}3n{gamma}){sup 150}Tb.

  10. Anthropogenic Black Carbon Emission Increase during the Last 150 Years at Coastal Jiangsu, China.

    Directory of Open Access Journals (Sweden)

    Kunshan Bao

    Full Text Available Black carbon (BC is one of the major drivers of climate change and a useful indicator of environmental pollution from industrialization, and thus it is essential to reconstruct the historical trend in BC flux to better understand its impact. The Yancheng coastal wetland reserve in Jiangsu province is an area sensitive to global sea level change and is also located in the most developed as well as most polluted region of China. We investigated the concentration and historical flux of BC over the past 150 years through geochemical analysis of two 210Pb-dated sediment cores from Yancheng coastal wetland. Measured BC contents ranged from 0.24 mg g-1 to 1.41 mg g-1 with average values of 0.51mg g-1-0.69 mg g-1, and BC fluxes ranged from 0.69 g m-2 yr-1 to 11.80 g m-2 yr-1 with averages of 2.94g m-2 yr-1-3.79 g m-2 yr-1. These values are consistent with other records worldwide. Both BC content and flux show a gradual and continuous increase over time and clearly reflect increased emissions from anthropogenic activities. The BC records have a significant peak in recent years (from 2000 to 2007, which is accompanied by the sharp increase of energy consumption and total carbon emission in the region. It is reasonable to conclude that changes in BC from increasing human activities have controlled BC fluxes during the last 150 years. Industrial contamination, especially BC emission, in the coastal region of eastern China should be taken into account when developing management strategies for protecting the natural environment.

  11. Molecular cloning, expression, and chromosomal localization of the gene encoding a human myeloid membrane antigen (gp150).

    Science.gov (United States)

    Look, A T; Peiper, S C; Rebentisch, M B; Ashmun, R A; Roussel, M F; Lemons, R S; Le Beau, M M; Rubin, C M; Sherr, C J

    1986-10-01

    DNA from a tertiary mouse cell transformant containing amplified human sequences encoding a human myeloid membrane glycoprotein, gp150, was used to construct a bacteriophage lambda library. A single recombinant phage containing 12 kilobases (kb) of human DNA was isolated, and molecular subclones were then used to isolate the complete gp150 gene from a human placental genomic DNA library. The intact gp150 gene, assembled from three recombinant phages, proved to be biologically active when transfected into NIH 3T3 cells. Molecular probes from the gp150 locus annealed with a 4.0-kb polyadenylated RNA transcript derived from human myeloid cell lines and from tertiary mouse cell transformants. The gp150 gene was assigned to human chromosome 15, and was subchromosomally localized to bands q25-26 by in situ hybridization. The chromosomal location of the gp150 gene coincides cytogenetically with the region assigned to the c-fes proto-oncogene, another human gene specifically expressed by myeloid cells.

  12. Mutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 mice.

    Directory of Open Access Journals (Sweden)

    Douglas Young

    Full Text Available Huntington's disease (HD is an autosomal dominant, progressive and fatal neurological disorder caused by an expansion of CAG repeats in exon-1 of the huntingtin gene. The encoded poly-glutamine stretch renders mutant huntingtin prone to aggregation. HdhQ150 mice genocopy a pathogenic repeat (∼150 CAGs in the endogenous mouse huntingtin gene and model predominantly pre-manifest HD. Treating early is likely important to prevent or delay HD, and HdhQ150 mice may be useful to assess therapeutic strategies targeting pre-manifest HD. This requires appropriate markers and here we demonstrate, that pre-symptomatic HdhQ150 mice show several dramatic mutant huntingtin gene-dose dependent pathological changes including: (i an increase of neuronal intra-nuclear inclusions (NIIs in brain, (ii an increase of extra-nuclear aggregates in dentate gyrus, (iii a decrease of DARPP32 protein and (iv an increase in glial markers of neuroinflammation, which curiously did not correlate with local neuronal mutant huntingtin inclusion-burden. HdhQ150 mice developed NIIs also in all retinal neuron cell-types, demonstrating that retinal NIIs are not specific to human exon-1 R6 HD mouse models. Taken together, the striking and robust mutant huntingtin gene-dose related changes in aggregate-load, DARPP32 levels and glial activation markers should greatly facilitate future testing of therapeutic strategies in the HdhQ150 HD mouse model.

  13. circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150

    Directory of Open Access Journals (Sweden)

    Junjun Luan

    2018-03-01

    Full Text Available Circular RNAs (circRNAs participate in the pathogenesis of various diseases by sponging microRNAs (miRs. However, the roles of circRNAs remain unreported in glomerular diseases. We previously reported that miR-150 positively correlated with renal chronicity index in patients with lupus nephritis (LN. We aimed to investigate renal circRNA profiling and the interaction between circRNAs and miR-150 in LN patients. Six renal biopsies from untreated female patients with LN class IV and five normal kidney tissues from urology patients were used for circRNA sequencing. 171 circRNAs with 2-fold differential expression were identified in LN compared with normal control. Ten selected circRNAs were validated by real-time qPCR, and seven circRNAs showed the same significant increases as the sequencing results. circHLA-C positively correlated with proteinuria (R = 0.92, p < 0.01, serum creatinine (R = 0.76, p = 0.08, renal activity index (R = 0.88, p < 0.05, and crescentic glomeruli (R = 0.93, p < 0.01. Renal circHLA-C increased 2.72-fold, and miR-150 decreased 66% in LN compared with normal control (p < 0.05. Bio-informatic analysis predicted miR-150 was regulated by circHLA-C and displayed one perfect match seed between circHLA-C and miR-150. The renal miR-150 showed a tendency of negative correlation with circHLA-C in LN patients. In conclusion, circHLA-C may play an important role in the pathogenesis of lupus nephritis by sponging miR-150.

  14. Asn-150 of Murine Erythroid 5-Aminolevulinate Synthase Modulates the Catalytic Balance between the Rates of the Reversible Reaction.

    Science.gov (United States)

    Stojanovski, Bosko M; Ferreira, Gloria C

    2015-12-25

    5-Aminolevulinate synthase (ALAS) catalyzes the first step in mammalian heme biosynthesis, the pyridoxal 5'-phosphate (PLP)-dependent and reversible reaction between glycine and succinyl-CoA to generate CoA, CO2, and 5-aminolevulinate (ALA). Apart from coordinating the positioning of succinyl-CoA, Rhodobacter capsulatus ALAS Asn-85 has a proposed role in regulating the opening of an active site channel. Here, we constructed a library of murine erythroid ALAS variants with substitutions at the position occupied by the analogous bacterial asparagine, screened for ALAS function, and characterized the catalytic properties of the N150H and N150F variants. Quinonoid intermediate formation occurred with a significantly reduced rate for either the N150H- or N150F-catalyzed condensation of glycine with succinyl-CoA during a single turnover. The introduced mutations caused modifications in the ALAS active site such that the resulting variants tipped the balance between the forward- and reverse-catalyzed reactions. Although wild-type ALAS catalyzes the conversion of ALA into the quinonoid intermediate at a rate 6.3-fold slower than the formation of the same quinonoid intermediate from glycine and succinyl-CoA, the N150F variant catalyzes the forward reaction at a mere 1.2-fold faster rate than that of the reverse reaction, and the N150H variant reverses the rate values with a 1.7-fold faster rate for the reverse reaction than that for the forward reaction. We conclude that the evolutionary selection of Asn-150 was significant for optimizing the forward enzymatic reaction at the expense of the reverse, thus ensuring that ALA is predominantly available for heme biosynthesis. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  15. The Rate Constant for the Reaction H + C2H5 at T = 295 - 150K

    Science.gov (United States)

    Pimentel, Andre S.; Payne, Walter A.; Nesbitt, Fred L.; Cody, Regina J.; Stief, Louis J.

    2004-01-01

    The reaction between the hydrogen atom and the ethyl (C2H3) radical is predicted by photochemical modeling to be the most important loss process for C2H5 radicals in the atmospheres of Jupiter and Saturn. This reaction is also one of the major sources for the methyl radicals in these atmospheres. These two simplest hydrocarbon radicals are the initial species for the synthesis of larger hydrocarbons. Previous measurements of the rate constant for the H + C2H5 reaction varied by a factor of five at room temperature, and some studies showed a dependence upon temperature while others showed no such dependence. In addition, the previous studies were at higher temperatures and generally higher pressures than that needed for use in planetary atmospheric models. The rate constant for the reaction H + C2H5 has been measured directly at T = 150, 202 and 295 K and at P = 1.0 Torr He for all temperatures and additionally at P = 0.5 and 2.0 Torr He at T = 202 K. The measurements were performed in a discharge - fast flow system. The decay of the C2H5 radical in the presence of excess hydrogen was monitored by low-energy electron impact mass spectrometry under pseudo-first order conditions. H atoms and C2H5 radicals were generated rapidly and simultaneously by the reaction of fluorine atoms with H2 and C2H6, respectively. The total rate constant was found to be temperature and pressure independent. The measured total rate constant at each temperature are: k(sub 1)(295K) = (1.02+/-0.24)x10(exp -10), k(sub 1)(202K) = (1.02+/-0.22)x10(exp -10) and k(sub 1)(150K) = (0.93+/-0.21)x10(exp -10), all in units of cu cm/molecule/s. The total rate constant derived from all the combined measurements is k(sub 1) = (l.03+/-0.17)x10(exp -10) cu cm/molecule/s. At room temperature our results are about a factor of two higher than the recommended rate constant and a factor of three lower than the most recently published study.

  16. Investigating Causes and Consequences of 150 Years of Channel Morphology Evolution in San Pablo Bay, California

    Science.gov (United States)

    Wegen, M. V.; Roelvink, J.; Jaffe, B. E.

    2010-12-01

    The Delta is an area where rivers draining the Central Valley and Sierras of California, including the Sacramento and San Joaquin Rivers, meet before discharging into the northeastern end of the San Francisco Estuary. San Pablo Bay, a sub-embayment in the northern Estuary, is circular with an area of about 250 km2 and an average tidal range of about 1.5 m. It is rather shallow (depths generally less than 4 m, average depth San Pablo Bay has changed markedly since the Gold Rush. Deposition of more than a quarter billion cubic meters of hydraulic gold mining debris reduced the average depth of San Pablo Bay by 85 cm in the middle and late 1800s. In the late 1900s the intertidal flats narrowed and the major channel in the Bay deepened as more sediment was lost to the sea than entered from rivers. Processes of sediment redistribution caused the main channel to become narrower as well, a trend observed over the last 150 years. It is not clear what is causing the change in channel geometry and the implications of the change in geometry on the seaward transport of sediment through San Pablo Bay. This study investigates the cause of this channel geometry development and its impact on the conveyance of sediment through and distribution within San Pablo Bay using a process-based, numerical model (Delft3D). The Delft3D model developed for this study is a 3D model that includes the k-ɛ turbulence model, wind, waves, multiple mud and sand fractions and salt-fresh water density differences, as well as schematized tidal and river flow boundary conditions. The approach is to perform different runs with equal forcing on different historic bathymetries. By keeping the bed in a fixed, non-erodible state, we can analyze the impact of the evolving San Pablo Bay morphology on the conveyance efficiency of water and sediments. Model results show what happens with sediment supplied by the Sacramento River and San Joaquin River as well as the behavior of different sediment classes on

  17. Off-Yrast low-spin structure of deformed nuclei at mass number A∼150

    Energy Technology Data Exchange (ETDEWEB)

    Krugmann, Andreas

    2014-07-14

    The present work consists of two independent parts. The first part deals with the investigation of the 0{sup +}{sub 1}→0{sup +}{sub 2} transition in {sup 150}Nd with inelastic electron scattering and in the second part a proton scattering experiment for the investigation of dipole excitations is presented. In the first part of this thesis a pioneer experiment in inelastic electron scattering is introduced. At an electron energy of 75 MeV, excitation energy spectra have been measured at the high resolution 169 spectrometer at the S-DALINAC. The aim of this investigation was the determination of the ρ{sup 2}(E0;0{sup +}{sub 1}→0{sup +}{sub 2}) transition strength in the heavy deformed nucleus {sup 150}Nd. The experimental form factor of this particular transition has been compared to a theoretical form factor that has been constructed by an effective density operator on a microscopic level with the help of the generator coordinate method. The required collective wave functions have been calculated in the Confined β soft rotor model. In this model-dependent analysis the E0 transition strength has been determined for the first time. Furthermore the evolution of the E0 transition strength as a function of the potential stiffness has been investigated from the X(5) phase shape transitional point to the Rigid Rotor limit. It has been shown, that the E0 strength is relatively high at the shape-phase transitional point and starts to decrease with increasing stiffness and vanishes completely at the Rigid Rotor limit. Additionally the wave functions of the macroscopic collective Confined β-soft rotor model have been compared to those from a microscopic mean field Hamiltonian. Good agreement has been found. The second part of this thesis covers a polarized-proton scattering experiment on the heavy deformed nucleus {sup 154}Sm, that has been performed at the RCNP in Osaka, Japan. Utilizing the method of polarization transfer observables, a separation of spinflip and non

  18. 150 años construyendo nación con ingenio propio

    Directory of Open Access Journals (Sweden)

    Diego Fernando Hernández Losada

    2011-02-01

    Full Text Available El presente artículo muestra el beneficio de las instituciones públicas, y los resultados del compromiso en la construcción de nación, que desde hace 150 años de vida académica emprendió la Facultad de Ingeniería de la Universidad Nacional de Colombia, la cual recibió, de manos de la Escuela Politécnica, creada el 24 de agosto de 1861 y adscrita al Colegio Militar, la “posta magna” de orientar y organizar los estudios de ingeniería en Colombia. La trayectoria sesquicentenaria de esta institución demuestra que la Facultad de Ingeniería de la Universidad Nacional de Colombia ha honrado con excelencia académica este legado, creando conocimiento y liderando procesos de innovación en los campos de la formación, la investigación y la extensión, con el insigne propósito de mejorar las condiciones y la calidad de vida de la sociedad colombiana, propiciando que la población menos favorecida encuentre en la Universidad Nacional de Colombia la mejor opción para su progreso y movilidad social, que sólo son posibles con el esfuerzo, consagración y el conocimiento que se adquiere en las aulas y en los laboratorios de la Facultad de Ingeniería, y que les es transmitido por docentes de excelsas calidades técnicas y humanas. La ingeniería enfrenta en el presente siglo el reto de alcanzar el desarrollo económico que sea sostenible, por eso se presentan también en este artículo los desafíos y las oportunidades que la Facultad de Ingeniería tendrá que resolver para contribuir a al logro de dicho reto. Es innegable que para continuar su protagonismo académico y social, a la Facultad de Ingeniería le obliga perpetuar los principios de excelencia académica que la han distinguido en sus primeros 150 años de existencia, y que se deben al apoyo del Estado, y a las altísimas calidades humanas y académicas tanto de sus estudiantes como de sus profesores.

  19. Preoperative evaluation, surgical procedure, follow up and results of 150 cochlear implantations.

    Science.gov (United States)

    Kyriafinis, G; Vital, V; Psifidis, A; Constantinidis, J; Nikolaou, A; Hitoglou-Antoniadou, M; Kouloulas, A

    2007-04-01

    The cochlear implantation is among the most important achievements of medicine and biotechnology in the last 20 years, because it allows individuals who had never heard or had lost their hearing to perceive sound and improve their quality of life. Selection criteria for candidates are strict and are evaluated in each individual by a scientific committee specially trained for implantations which includes Ear Nose and Throat (ENT) surgeon, audiologist, psychiatrist and speech therapist. In our department, the first cochlear implantation was performed in 1995. During the last ten years more than 250 individuals have been evaluated due to profound hearing loss and 170 of them were found to be suitable candidates for cochlear implantation. One hundred and fifty (150) have already been operated and most of them are children with congenital hearing loss. No major or permanent complications were recorded in any of our 150 patients. Activation and fitting/mapping of the cochlear implant is initiated three weeks post-operatively. Regular follow-up and mapping of the implant are held, more frequently in children, along with specialized speech therapy. Each new mapping is evaluated according to the record of the patient with regard to the acoustic perception of sounds and speech and the discrimination of individual elements of phonation based on a protocol that we have created for the needs of Greek language. Speech discrimination (AHEPA Hospital protocol), before the Implantation, at the activation of the cochlear implant and till 4 years of the follow-up showed that in our patients, we obtained better and faster results in post-speech acquisition adults with recent or chronic deafness and in children with congenital deafness operated before the 5th year of age, who underwent special preoperative speech therapy programme, fact which is in agreement with current literature. Patient satisfaction evaluated by "Sanders" psychometrics tests, was achieved in accordance to pre

  20. An In Vivo Functional Screen Uncovers miR-150-Mediated Regulation of Hematopoietic Injury Response

    Directory of Open Access Journals (Sweden)

    Brian D. Adams

    2012-10-01

    Full Text Available Hematopoietic stem and progenitor cells are often undesired targets of chemotherapies, leading to hematopoietic suppression requiring careful clinical management. Whether microRNAs control hematopoietic injury response is largely unknown. We report an in vivo gain-of-function screen and the identification of miR-150 as an inhibitor of hematopoietic recovery upon 5-fluorouracil-induced injury. Utilizing a bone marrow transplant model with a barcoded microRNA library, we screened for barcode abundance in peripheral blood of recipient mice before and after 5-fluorouracil treatment. Overexpression of screen-candidate miR-150 resulted in significantly slowed recovery rates across major blood lineages, with associated impairment of bone marrow clonogenic potential. Conversely, platelets and myeloid cells from miR-150 null marrow recovered faster after 5-fluorouracil treatment. Heterozygous knockout of c-myb, a conserved target of miR-150, partially phenocopied miR-150-forced expression. Our data highlight the role of microRNAs in controlling hematopoietic injury response and demonstrate the power of in vivo functional screens for studying microRNAs in normal tissue physiology.

  1. Evaluation of the bioequivalence of capsules containing 150 mg of fluconazole.

    Science.gov (United States)

    Porta, V; Chang, K H; Storpirtis, S

    2005-01-06

    Fluconazole is an antifungal agent. The purpose of this study was to evaluate bioequivalence of two commercial 150 mg capsule formulations of fluconazole available in the Brazilian market. The study was an open, randomized, two-period, two-group crossover trial with a 2-week washout interval. Blood samples were collected throughout a 96-h period after administration of reference product (R) and test product (T) to 28 fasting volunteers. A simple, accurate, precise and sensitive high-performance liquid chromatographic (HPLC) method with ultraviolet detection was developed and validated for quantification of fluconazole in plasma samples after liquid-liquid extraction. Bioequivalence between the products was determined by calculating 90% confidence intervals (90% C.I.) for the ratio of C(max), AUC(0-t) and AUC(0-infinity) values for the test and reference products, using logarithmic transformed data. The 90% confidence intervals for the ratio of C(max) (101.06-105.45%), AUC(0-t) (97.11-104.69%) and AUC(0-infinity) (97.96-103.36%) values for the test and reference products are within the 80-125% interval, proposed by FDA and EMEA. It was concluded that the two fluconazole formulations are bioequivalent in their rate and extent of absorption.

  2. Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature.

    Science.gov (United States)

    Silva-Fernández, Lucía; Otón, Teresa; Askanase, Anca; Carreira, Patricia; López-Longo, Francisco Javier; Olivé, Alejandro; Rúa-Figueroa, Íñigo; Narváez, Javier; Ruiz-Lucea, Esther; Andrés, Mariano; Calvo, Enrique; Toyos, Francisco; Alegre-Sancho, Juan José; Tomero, Eva; Montilla, Carlos; Zea, Antonio; Uriarte, Esther; Calvo-Alén, Jaime; Marras, Carlos; Martínez-Taboada, Víctor M; Belmonte-López, María Ángeles; Rosas, José; Raya, Enrique; Bonilla, Gema; Freire, Mercedes; Pego-Reigosa, José María; Millán, Isabel; Hughes-Morley, Adwoa; Andreu, José Luis

    2017-05-18

    The course and long-term outcome of pure membranous lupus nephritis (MLN) are little understood. The aims of this study are to evaluate the clinical features, course, outcome and prognostic indicators in pure MLN and to determine the impact of ethnicity and the type of health insurance on the course and prognosis of pure MLN. We conducted a retrospective review of medical records of 150 patients with pure MLN from Spain and the USA. Mean age was 34.2±12.5 and 80% were women. Sixty-eight percent of patients had nephrotic syndrome at diagnosis. The average serum creatinine was 0.98±0.78mg/dl. Six percent of patients died and 5.3% developed end-stage renal disease (ESRD). ESRD was predicted by male sex, hypertension, dyslipidemia, high basal 24h-proteinuria, high basal serum creatinine and a low basal creatinine clearance. Age, cardiac insufficiency, peripheral artheriopathy, hemodialysis and not having received mycophenolate mofetil or antimalarials for MLN predicted death. Pure MLN frequently presents with nephrotic syndrome, high proteinuria and normal serum creatinine. Its prognosis is favourable in maintaining renal function although proteinuria usually persists over time. Baseline cardiovascular disease and not having a health insurance are related with poor prognosis. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  3. Aeolian particle transport inferred using a ~150-year sediment record from Sayram Lake, arid northwest China

    Directory of Open Access Journals (Sweden)

    Long Ma

    2015-05-01

    Full Text Available We studied sediment cores from Sayram Lake in the Tianshan Mountains of northwest China to evaluate variations in aeolian transport processes over the past ~150 years. Using an end-member modeling algorithm of particle size data, we interpreted end members with a strong bimodal distribution as having been transported by aeolian processes, whereas other end members were interpreted to have been transported by fluvial processes. The aeolian fraction accounted for an average of 27% of the terrigenous components in the core. We used the ratio of aeolian to fluvial content in the Sayram Lake sediments as an index of past intensity of aeolian transport in the Tianshan Mountains. During the interval 1910-1930, the index was high, reflecting the fact that dry climate provided optimal conditions for aeolian dust transport. From 1930-1980, the intensity of aeolian transport was weak. From the 1980s to the 2000s, aeolian transport to Sayram Lake increased. Although climate in northwest China became more humid in the mid-1980s, human activity had by that time altered the impact of climate on the landscape, leading to enhanced surface erosion, which provided more transportable material for dust storms. Comparison of the Lake Sayram sediment record with sediment records from other lakes in the region indicates synchronous intervals of enhanced aeolian transport from 1910 to 1930 and 1980 to 2000.

  4. Future Automotive Aftertreatment Solutions: The 150°C Challenge Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Zammit, Michael; DiMaggio, Craig L.; Kim, Chang H.; Lambert, Christine; Muntean, George G.; Peden, Charles HF; Parks, James E.; Howden, Ken

    2013-10-15

    With future fuel economy standards enacted, the U.S. automotive manufacturers (OEMs) are committed to pursuing a variety of high risk/highly efficient stoichiometric and lean combustion strategies to achieve superior performance. In recognition of this need, the U.S. Department of Energy (DOE) has partnered with domestic automotive manufacturers through U.S. DRIVE to develop these advanced technologies. However, before these advancements can be introduced into the U.S. market, they must also be able to meet increasingly stringent emissions requirements. A significant roadblock to this implementation is the inability of current catalyst and aftertreatment technologies to provide the required activity at the much lower exhaust temperatures that will accompany highly efficient combustion processes and powertrain strategies. Therefore, the goal of this workshop and report is to create a U.S. DRIVE emission control roadmap that will identify new materials and aftertreatment approaches that offer the potential for 90% conversion of emissions at low temperature (150°C) and are consistent with highly efficient combustion technologies currently under investigation within U.S. DRIVE Advanced Combustion and Emission Control (ACEC) programs.

  5. Bipolar Thermofusion BiClamp 150 in Thyroidectomy: A Review of 1156 Operations

    Directory of Open Access Journals (Sweden)

    Tomáš Pniak

    2014-01-01

    Full Text Available Objectives. To compare the bipolar thermofusion BiClamp 150 with conventional ligature techniques for thyroid gland surgery, and report the advantages/disadvantages of both techniques. Methods. In this retrospective comparative study, all thyroid gland operations performed in the ENT Clinic Faculty Hospital Ostrava from 2006 to 2013 were included (1156 operations, 2122 lobes. Patients were categorized into two groups according to the type of vessel sealing method used, group I (BiClamp, n=819 operations and group II (conventional ligature, n=337 operations. The number of revision surgeries due to wound hematoma was recorded as a bleeding event. Statistical analysis of the complication rate (bleeding rate, recurrent nerve palsy and time of duration was performed. Results. The rate of revision surgery performed due to postoperative wound hematoma was significantly lower in group I (15/819, 1.83% compared with group II (14/337, 4.15% (P=0.022. There was no statistically significant difference in the frequency of recurrent laryngeal nerve palsy between groups I and II (P=0.36. The average surgery time was significantly shorter in group I (P<0.001. Conclusion. Bipolar thermofusion BiClamp is an effective vessel sealing method that leads to a significant reduction in postoperative wound bleeding rates and reduces surgical time compared with conventional vessel ligature.

  6. Evolution of laparoscopic surgery in a high volume hepatobiliary unit: 150 consecutive pure laparoscopic hepatectomies.

    Science.gov (United States)

    López-Ben, Santiago; Ranea, Alejandro; Albiol, M Teresa; Falgueras, Laia; Castro, Ernesto; Casellas, Margarida; Codina-Barreras, Antoni; Figueras, Joan

    2017-05-01

    Compared to other surgical areas, laparoscopic liver resection (LLR) has not been widely implemented and currently less than 20% of hepatectomies are performed laparoscopically worldwide. The aim of our study was to evaluate the feasibility, and the ratio of implementation of LLR in our department. We analyzed a prospectively maintained database of 749 liver resections performed during the last 10-year period in a single centre. A total of 150 (20%) consecutive pure LLR were performed between 2005 and 2015. In 87% of patients the indication was the presence ofprimary or metastatic liver malignancy. We performed 30 major hepatectomies (20%) and (80%) were minor resections, performed in all liver segments. Twelve patients were operated twice and 2 patients underwent a third LLR. The proportion of LLR increased from 12% in 2011 to 62% in the last year. Conversion rate was 9%. Overall morbidity rate was 36% but only one third were classified as severe. The 90-day mortality rate was 1%. Median hospital stay was 4 days and the rate of readmissions was 6%. The implementation of LLR has been fast with morbidity and mortality comparable to other published series. In the last 2 years more than half of the hepatectomies are performed laparoscopically in our centre. Copyright © 2017 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  7. Effect of Cr content on the FAC of pipe material at 150 .deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Park, Tae Jun; Kim, Hong Pyo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-06-15

    Flow accelerated corrosion (FAC) of the carbon steel piping in nuclear power plants (NPPs) has been major issue in nuclear industry. During the FAC, a protective oxide layer on carbon steel dissolves into flowing water leading to a thinning of the oxide layer and accelerating corrosion of base material. As a result, severe failures may occur in the piping and equipment of NPPs. Effect of alloying elements on FAC of pipe materials was studied with rotating cylinder FAC test facility at 150 .deg. C and at flow velocity of 4m/s. The facility is equipped with on line monitoring of pH, conductivity, dissolved oxygen(DO) and temperature. Test solution was the demineralized water, and DO concentration was less than 1 ppb. Surface appearance of A 106 Gr. B which is used widely in secondary pipe in NPPs showed orange peel appearance, typical appearance of FAC. The materials with Cr content higher than 0.17wt.% showed pit. The pit is thought to early degradation mode of FAC. The corrosion product within the pit was enriched with Cr, Mo, Cu, Ni and S. But S was not detected in SA336 F22V with 2.25wt.% Cr. The enrichment of Cr and Mo seemed to be related with low, solubility of Cr and Mo compared to Fe. Measured FAC rate was compared with Ducreaux's relationship and showed slightly lower FAC rate than Ducreaux's relationship.

  8. Open architecture time of flight 3D SWIR camera operating at 150 MHz modulation frequency.

    Science.gov (United States)

    Wheaton, Skyler; Bonakdar, Alireza; Nia, Iman Hassani; Tan, Chee Leong; Fathipour, Vala; Mohseni, Hooman

    2017-08-07

    In the past two decades 3-D cameras have proven to be one of the next revolutions in machine vision. However, these devices are still an emerging technology with a particularly narrow set of commercially available devices. In this paper, the concept and execution of the first short wavelength infrared (SWIR) time-of-flight (ToF) 3-D camera system operating at a wavelength of 1550 nm is presented. By decoupling the optical and electrical components of the system in an open architecture we not only surpass many of the limitations of an on-chip integrated solution, but also can easily change the imaging device based on the requirements of the application. We achieve modulation frequencies up to 150 MHz, which exceeds the conventional values currently published for other large format modulators by about five times. This increase in the modulation frequency allows for a TOF camera with significantly higher depth resolution, while the open architecture design allows for a highly reconfigurable device that can be modified for specific working conditions.

  9. Planck intermediate results. XXVI. Optical identification and redshifts of Planck clusters with the RTT150 telescope

    Science.gov (United States)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Barrena, R.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bikmaev, I.; Böhringer, H.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Burenin, R.; Burigana, C.; Butler, R. C.; Calabrese, E.; Carvalho, P.; Catalano, A.; Chamballu, A.; Chiang, H. C.; Chon, G.; Christensen, P. R.; Churazov, E.; Clements, D. L.; Colombo, L. P. L.; Comis, B.; Couchot, F.; Curto, A.; Cuttaia, F.; Dahle, H.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Diego, J. M.; Dole, H.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Finelli, F.; Flores-Cacho, I.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Fromenteau, S.; Galeotta, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Gilfanov, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Hempel, A.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Khamitov, I.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maino, D.; Mandolesi, N.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; Mazzotta, P.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Nørgaard-Nielsen, H. U.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reinecke, M.; Remazeilles, M.; Renault, C.; Ricciardi, S.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Scott, D.; Spencer, L. D.; Stolyarov, V.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vibert, L.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2015-10-01

    We present the results of approximately three years of observations of Planck Sunyaev-Zeldovich (SZ) sources with the Russian-Turkish 1.5 m telescope (RTT150), as a part of the optical follow-up programme undertaken by the Planck collaboration. During this time period approximately 20% of all dark and grey clear time available at the telescope was devoted to observations of Planck objects. Some observations of distant clusters were also done at the 6 m Bolshoi Telescope Alt-azimutalnyi (BTA) of the Special Astrophysical Observatory of the Russian Academy of Sciences. In total, deep, direct images of more than one hundred fields were obtained in multiple filters. We identified 47 previously unknown galaxy clusters, 41 of which are included in the Planck catalogue of SZ sources. The redshifts of 65 Planck clusters were measured spectroscopically and 14 more were measured photometrically. We discuss the details of cluster optical identifications and redshift measurements. We also present new spectroscopic redshifts for 39 Planck clusters that were not included in the Planck SZ source catalogue and are published here for the first time.

  10. 150 years of the New York Academy of Medicine: a series of exhibitions.

    Science.gov (United States)

    Black, L F; North, M J

    1996-01-01

    As the New York Academy of Medicine celebrates its 150th year as a leader in the field of urban health, it is instructive to review the events and decisions that influenced and shaped it. Since its inception, the Academy has taken an active role in lobbying state and local governments to enact more-effective public health laws and in educating the public about improving health conditions. During 1996 and 1997, the Academy Library's Historical Collections is mounting a series of six exhibitions that are intended to tell the story of public health in New York as influenced by the New York Academy of Medicine. The story will be told using printed books, pamphlets, posters, photographs, and manuscripts drawn from the Library's collections, as well as the Academy's archives. Each exhibition will highlight the Academy's accomplishments in the subject areas presented. In this article, we summarize all six of the exhibitions and offer an in-depth look at the first two exhibitions.

  11. [150th birth anniversary of Izidor Brennsohn, Latvian historian of medicine and researcher of Lithuanian anthropology].

    Science.gov (United States)

    Andriusis, Aurimas; Viksna, Arnis

    2004-01-01

    This publication is dedicated to the 150th birth anniversary of a famous German-writing Latvian physician, historian of medicine, and anthropologist of Jewish descent Izidor Brennsohn, and to his ties with Lithuania. I. Brennsohn's works on physicians and the development of health care in Kurland, Livland, and Estland laid the foundations for the contemporary historiography of medicine in Latvia and Estonia. To a certain extent, these works could also be viewed as a digest of the sources of Lithuanian history of medicine, especially in regard to the regions on the boarder with Latvia, as well as to various personalities. However, Brennsohn's most important link with Lithuania was his doctoral thesis "On Lithuanian anthropology" ("Zur Anthropologie der Litauer"), defended at Dorpat (Tartu) University in 1883. It was one of the first works dealing with Lithuanian ethnic anthropology as a whole. Although, material of thesis could not be used for wider generalizations, still, it is one of rare and valuable 19th century sources of Lithuanian anthropology. Brennsohn's legacy deserves greater attention from people researching medical history in Lithuania.

  12. Characterization of 150 $\\mu$m thick epitaxial silicon detectors from different producers after proton irradiation

    CERN Document Server

    Hoedlmoser, H; Haerkoenen, J; Kronberger, M; Trummer, J; Rodeghiero, P

    2007-01-01

    Epitaxial (EPI) silicon has recently been investigated for the development of radiation tolerant detectors for future high-luminosity HEP experiments. A study of 150 mm thick EPI silicon diodes irradiated with 24GeV=c protons up to a fluence of 3 1015 p=cm2 has been performed by means of Charge Collection Efficiency (CCE) measurements, investigations with the Transient Current Technique (TCT) and standard CV=IV characterizations. The aim of the work was to investigate the impact of radiation damage as well as the influence of the wafer processing on the material performance by comparing diodes from different manufacturers. The changes of CCE, full depletion voltage and leakage current as a function of fluence are reported. While the generation of leakage current due to irradiation is similar in all investigated series of detectors, a difference in the effective doping concentration can be observed after irradiation. In the CCE measurements an anomalous drop in performance was found even for diodes exposed to ...

  13. [Clinicopathologic and biological correlations (PSA-PAP) in pathology of the prostate. Apropos of 150 cases].

    Science.gov (United States)

    Amiel, J; Chevallier, D; Peyrottes, A; Benoliel, J; Toubol, J

    1990-01-01

    On the basis of 150 patients (16 controls with no disease of the prostate, 96 cases of benign prostatic hypertrophy (BPH) and 38 cases of carcinoma of the prostate (CP)), the authors intended to answer 3 questions: How can the borderline values of PSA in BPH be interpreted? Is there a correlation between the Gleason and PSA values in carcinomas? Should the simultaneous measurements of PSA and PAP be continued? All patients were examined with a rectal touch, transrectal echography (TRE) and PAS and PAP assays. All CP were examined with bone radionuclide scanning (BR). The correlation coefficient being 0.391 (p 0.001), the PSA value and prostatic weight can be regarded as linearly correlated in BPH (5 g BPH = 1 ng/ml PSA). This lower value of PSA is linked with the increase produced by TRE in the assessment of prostatic weight. On the other hand, the authors did no observe a correlation between the PSA and the Glisson grade in carcinomas with negative BR. Lastly, the sensitivity of PSA is noticeably higher than that of PAP (75% vs. 50%), and no false negative finding with PSA was corrected by PAP measurements.

  14. [Anatomoclinical and biologic correlations in prostatic pathology. Apropos of 150 case reports].

    Science.gov (United States)

    Amiel, J; Chevallier, D; Peyrottes, A; Benoliel, J; Toubol, J

    1989-01-01

    The authors analyzed 150 patient files (16 controls with no prostatic pathology, 96 patients with benign prostatic hypertrophy (BPH), 38 prostate cancer patients) in an attempt to answer three questions: how should borderline values of PSA be interpreted in patients with BPH; is there a correlation between the Gleason grade and PSA levels in prostate cancer? Should both PSA and PAP concentrations be assayed? All patients underwent digital rectal examination and transrectal ultrasonography (TU), and were assayed for PSA and PAP. All prostate cancer patients had a bone scintigraphy (Bs). In view of the correlation coefficient of 0.391 (p less than 0.001), it can be affirmed that PSA and weight are linearly correlated in BPH (5 g BPH = 1 ng/ml PSA). This lower value of PSA is due to the overevaluation of prostate weight by TU. In contrast, the authors did not find any correlation between the PSA level and the Gleason grade in prostate cancer patients with a negative bone scintiscan. Finally, the sensitivity of PSA was markedly better than that of PAP (75% vs 50%), and no PSA false negative error was corrected by the PAP value.

  15. Laparoscopic Cholecystectomy Under Spinal Anesthesia with Low-Pressure Pneumoperitoneum - Prospective Study of 150 Cases

    Directory of Open Access Journals (Sweden)

    Sunder Goyal

    2012-08-01

    Materials and Methods: In a private rural medical college, 150 patients were selected prospectively for laparoscopic cholecystectomy, under low-pressure (8mmHg pneumoperitoneum and under spinal anesthesia over a span of one and a half years. Injection bupivacaine (0.5% was used for spinal anesthesia. All ports were made in a head-down position to avoid hypotension. Shoulder pain was managed by reassurance as well as by diverting the attention and sedation in a few cases. Results: We successfully performed the operations in 145 patients without major complications. Spinal anesthesia was converted to general anesthesia in five patients due to severe shoulder pain. Age varied between 21 and 75 years. Duration of operation time (skin to skin was between 40 and 80 minutes. Twenty-nine patients complained of right shoulder pain. Most of them were managed by reassurance from the anesthetist and a few needed an injection of fentanyl along with midazolam. Conclusion: Laparoscopic cholecystectomy with low-pressure CO2 pneumoperitoneum is feasible and safe under spinal anesthesia. Incidence of postoperative shoulder pain and complications are comparable with laparoscopic cholecystectomy under general anesthesia. [Arch Clin Exp Surg 2012; 1(4.000: 224-228

  16. Neutron induced inelastic cross sections of 150Sm for En = 1 to 35 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Dashdorj, D; Mitchell, G E; Kawano, T; Becker, J A; Agvaanluvsan, U; Chadwick, M B; Cooper, J R; Devlin, M; Fotiades, N; Garrett, P E; Nelson, R O; Wu, C Y; Younes, W

    2006-08-16

    Cross-section measurements were made of prompt gamma-ray production as a function of incident neutron energy (E{sub n} = 1 to 35 MeV) on an enriched (95.6%) {sup 150}Sm sample. Energetic neutrons were delivered by the Los Alamos National Laboratory spallation neutron source located at the Los Alamos Neutron Science Center (LANSCE) facility. The prompt-reaction gamma rays were detected with the large-scale Compton-suppressed Germanium Array for Neutron Induced Excitations (GEANIE). Neutron energies were determined by the time-of-flight technique. The {gamma}-ray excitation functions were converted to partial {gamma}-ray cross sections taking into account the dead-time correction, target thickness, detector efficiency and neutron flux (monitored with an in-line fission chamber). Partial {gamma}-ray cross sections were predicted using the Hauser-Feshbach statistical reaction code GNASH. Above E{sub n} {approx} 8 MeV the pre-equilibrium reaction process dominates the inelastic reaction. The spin distribution transferred in pre-equilibrium neutron-induced reactions was calculated using the quantum mechanical theory of Feshbach, Kerman, and Koonin (FKK). These pre-equilibrium spin distributions were incorporated into a new version of GNASH and the {gamma}-ray production cross sections were calculated and compared with experimental data. The difference in the partial {gamma}-ray cross sections using spin distributions with and without pre-equilibrium effects is discussed.

  17. Endovascular management of dural arteriovenous fistulas of the transverse and sigmoid sinus in 150 patients

    Energy Technology Data Exchange (ETDEWEB)

    Kirsch, M. [Ernst-Moritz-Arndt-Universitaet Greifswald, Institut fuer Diagnostische Radiologie und Neuroradiologie, Greifswald (Germany); Liebig, T. [TU Muenchen, Institut fuer Neuroradiologie, Klinikum Rechts der Isar, Munich (Germany); Kuehne, D. [Klinik fuer Radiologie und Neuroradiologie, Alfried-Krupp-Krankenhaus, Essen (Germany); Henkes, H. [Katharinenhospital-Klinikum Stuttgart, Klinik fuer Neuroradiologie, Stuttgart (Germany)

    2009-07-15

    This study aimed to evaluate the safety and efficiency of the endovascular treatment of transverse-sigmoid sinus dural arteriovenous fistulas (TS{sub d}AVF). A total of 150 consecutive patients and 348 procedures were evaluated. Pulsatile tinnitus (81%), headache (15%), and intracranial hemorrhage (10%) were the most frequent manifestations of the TS{sub d}AVFs. More than half of the affected sinuses were partially or completely thrombosed. Access-wise treatment was performed transarterial (n = 33), transvenous (n = 21), or a combination thereof (n = 96). A mean of 2.4 procedures per patient was required. Immediate postprocedural occlusion rate after transarterial embolization was 30% only. Transvenous treatment alone resulted in an early occlusion rate of 81%, with delayed complete obliteration of half of the remaining fistulas. After combined transarterial/transvenous treatment, the angiographic cure rate was 54%. At follow-up, 88% of patients with residual shunt after the treatment showed complete occlusion. The cumulative complication rate was 9% (n = 13), with minor adverse events in ten patients (7%) and major complications in three patients (2%). Transvenous coil occlusion of the sinus segment with the adjacent dAVF site, eventually combined with transarterial occlusion of supplying arteries, is a very effective and well-tolerated treatment method. In selected patients, variations of these methods (e.g., sinus stenting, compartmental sinus occlusion) can be useful. (orig.)

  18. A medical enigma : what "gale chinoise (Chinese scabies)" meant 150 years ago.

    Science.gov (United States)

    Gaüzere, B-A; Aubry, P

    2017-06-01

    The meaning of the term "gale chinoise" mentioned in some articles about French overseas territories in the 19th century, remains unclear. In response to a query of an American colleague dermatologist trying to find out what it meant 150 years ago, we attempted to elucidate the nature of this ancient disease, which today would be translated literally as Chinese scabies. We submitted the query to a panel of civilian and military French tropical medicine specialists including dermatologists, through two networks : Association Amicale Santé Navale et d'Outre-Mer and Société de Pathologie Exotique. Very few answers were received from the approximately 400 colleagues in these networks. They mentioned : ciguatera, other types of ichtyosarcotoxism, smallpox, and leprosy. Several said they never encountered this term during many years spent in French Polynesia, and none was able to find irrefutable proof of their suggestion. Discussion and conclusion. Leprosy, smallpox, ciguatera? The identity of "gale chinoise" remains an enigma ; it might have been intended to designate several different diseases.

  19. A new glimpse on Mesozoic zooplankton-150 million-year-old lobster larvae.

    Science.gov (United States)

    Haug, Joachim T; Haug, Carolin

    2017-01-01

    Larvae of malacostracan crustaceans represent a large fraction of modern day zooplankton. Plankton is not only a major part of the modern marine ecosystem, but must have played an important role in the ecosystems of the past as well. Unfortunately, our knowledge about plankton composition of the past is still quite limited. As an important part of today's zooplankton, malacostracan larvae are still a rarity in the fossil record; many types of malacostracan larvae dominating the modern plankton have so far not been found as fossils. Here we report a new type of fossil malacostracan larva, found in the 150 million years old lithographic limestones of southern Germany (Solnhofen Lithographic Limestones). The three rather incomplete specimens mainly preserve the telson. A pronounced middle spine on the posterior edge of these specimens indicates that they are either larval forms of a clawed lobster or of an axiidean lobster, or of a closer relative to one of the two groups. The tergo-pleura are drawn out into distinct spines in one specimen, further supporting the interpretation as a larva of a clawed lobster or an early relative. The telson morphology also shows adaptations to a prolonged planktic life style, the latero-posterior edges are drawn out into distinct spines. Similar adaptations are known in larvae of the modern homarid lobster Nephrops norvegicus, not necessarily indicating a closer relationship, but convergent life styles. The new finds provide an important new insight into the composition of Mesozoic zooplankton and demonstrate the preservation potential of lithographic limestones.

  20. 150K - 200K miniature pulse tube cooler for micro satellites

    Science.gov (United States)

    Chassaing, Clément; Butterworth, James; Aigouy, Gérald; Daniel, Christophe; Crespin, Maurice; Duvivier, Eric

    2014-01-01

    Air Liquide is working with the CNES and Steel électronique in 2013 to design, manufacture and test a Miniature Pulse Tube Cooler (MPTC) to cool infrared detectors for micro-satellite missions. The cooler will be particularly adapted to the needs of the CNES MICROCARB mission to study atmospheric Carbon Dioxide which presents absorption lines in the thermal near infrared, at 1.6 μm and 2.0 μm. The required cooler temperature is from 150 to 200K with cooling power between 1 and 3 watts. The overall electrical power budget including electronics is less than 20W with a 288-300K rejection temperature. Particular attention is therefore paid to optimizing overall system efficiency. The active micro vibration reduction system and thermal control systems already developed for the Air Liquide Large Pulse Tube Cooler (LPTC) are currently being implemented into a new high efficiency electronic architecture. The presented work concerns the new cold finger and electronic design. The cooler uses the compressor already developed for the 80K Miniature Pulse Tube Cryocooler. This Pulse Tube Cooler addresses the requirements of space missions where extended continuous operating life time (>5 years), low mass and low micro vibration levels are critical.

  1. Biópsia per-oral do intestino delgado em 150 casos de diferentes enteroparasitoses

    Directory of Open Access Journals (Sweden)

    Norton de Figueiredo

    1967-04-01

    Full Text Available Os autores fazem uma apresentação sumária de alguns tipos de instrumentos utilizados na realização da biópsia duodeno-jejunal através intubação oral, ao mesmo tempo que comentam a importância do método no estudo da patologia intestinal. Em seguida apresentam os resultados de sua experiência empregando 6 diferentes tipos de sondas e mostram os resultados histopatológicos observados em 150 casos de diversas parasitoses intestinais, submetidos a estudo. Entre os resultados chamam a atenção para a presença freqüente da Giardia lamblia, detectada em 16 dos 50 (32% casos desta parasitose, contra 3 dos 27 (11,1% de esquistossomose e apenas 2 dos 108 (1,8% de estrongiloidíase. Relatam também o achado de numerosas leishmânias no córion da mucosa jejunal de um paciente parasitado pela Giardia lamblia, que era portador de Calazar. Apreciam, ainda, o significado de outras alterações, consideradas inespecíficas, sobre as quais aguardam estudos mais completos, para chegar a conclusões mais válidas. Entre estas, merece destaque o achado de atrofia das vilosidades intestinais em 27 pacientes infectados pelo Strongyloides stercoialis tendo que em 5 dêles havia parasitismo exclusivo pelo referido nematóide.

  2. [150 years since the birth of R. Koch--his life and work].

    Science.gov (United States)

    Pospisil, R

    1994-12-01

    In December 1993 150 years have elapsed since the birth of Robert Koch. Koch began his research activities already as a rural physician. Later, from 1880 he worked in the Imperial Health Institute in Berlin, from 1885 he was as professor in charge of the Institute of Hygiene of the Medical Faculty of Berlin University. Greater opportunities for research were offered to him in the Institute for Infectious Diseases in Berlin. R. Koch laid the foundations of scientific microbiology, his activities were, however, also closely linked with epidemiology. His discoveries include evidence of B. anthracis, V. cholerae and in particular M. tuberculosis (1882). He studied also the etiology of wound infections. He enriched microbiology by new cultivation, staining and microscopic techniques, by using vapour during sterilization as well as investigations of the effect of new disinfectants. A major part of his research was devoted to tropical diseases which he studied during six expeditions. Koch was not only concerned with laboratory research, he implemented also many epidemiological field projects. Many scientists who later became famous worked with him. In 1905 Koch was awarded the Nobel Prize. R. Koch died on May 27, 1910.

  3. Understanding the Biocompatibility of Sintered Calcium Phosphate with Ratio of [Ca]/[P] = 1.50

    Directory of Open Access Journals (Sweden)

    Feng-Lin Yen

    2012-01-01

    Full Text Available Biocompatibility of sintered calcium phosphate pellets with [Ca]/[P] = 1.50 was determined in this study. Calcium pyrophosphate (CPP phase formed on the sintered pellets immersed in a normal saline solution for 14 d at 37∘C. The intensities of hydroxyapatite (HA reflections in the X-ray diffraction (XRD patterns of the pellets were retrieved to as-sintered state. The pellet surface morphology shows that CPP crystallites were clearly present and make an amorphous calcium phosphate (ACP to discriminate against become to the area of slice join together. In addition, the intensities of the CPP reflections in the XRD patterns were the highest when the pellets were immersed for 28 d. When the CPP powders were extracted from the pellets after immersion in the solution for 14 d, the viability of 3T3 cells remained above 90% for culture times from 1 to 4 d. The pellet surface morphology observed using optical microscopy showed that the cells did not adhere to the bottom of the sintered pellets when cultured for 4 d; however, some CPP phase precipitates were formed, as confirmed by XRD. In consequence, the results suggest that the sintered HA powders are good materials for use in biomedical applications because of their good biocompatibility.

  4. Effective treatment of osteoarthritis with a 150 mg prolonged-release of diclofenac sodium.

    Science.gov (United States)

    Arcangeli, P; Andreotti, L; Palazzini, E

    1996-01-01

    A new oral dosage form of diclofenac sodium, enabling the single administration of the daily dose of 150 mg, has been tested for treatment of 20 patients suffering from osteoarthritis of the spine. A control group of 20 patients with the same diagnosis instead received 3 enteric-coated tablets/day, each containing 50 mg of the drug. Treatments lasted in both groups one month. Clinical efficacy was monitored by evaluating the changes in the disease's symptoms and signs (pain, cramps, alterations of function capacity, morning stiffness) and in some laboratory parameters (ESR, C-reactive protein, Rheuma test). Treatment tolerability was evaluated through the routine laboratory blood and urine tests, and by registering any complaint at the gastrointestinal level, as well as any adverse event. The two posology schemes were equally effective in favourably reducing the disease's clinical and laboratory manifestations. Also systemic and local tolerability were superimposable and on the whole good: only a few episodes of mild epigastralgia were reported (3 cases in each group), as expected during a treatment course with NSAIDs.

  5. From protoplasmic theory to cellular systems biology: a 150-year reflection.

    Science.gov (United States)

    Welch, G Rickey; Clegg, James S

    2010-06-01

    Present-day cellular systems biology is producing data on an unprecedented scale. This field has generated a renewed interest in the holistic, "system" character of cell structure-and-function. Underlying the data deluge, however, there is a clear and present need for a historical foundation. The origin of the "system" view of the cell dates to the birth of the protoplasm concept. The 150-year history of the role of "protoplasm" in cell biology is traced. It is found that the "protoplasmic theory," not the "cell theory," was the key 19th-century construct that drove the study of the structure-and-function of living cells and set the course for the development of modern cell biology. The evolution of the "protoplasm" picture into the 20th century is examined by looking at controversial issues along the way and culminating in the current views on the role of cytological organization in cellular activities. The relevance of the "protoplasmic theory" to 21st-century cellular systems biology is considered.

  6. QRS frequency characteristics help predict response to cardiac resynchronization in left bundle branch block less than 150 milliseconds.

    Science.gov (United States)

    Niebauer, Mark J; Rickard, John; Polakof, Landon; Tchou, Patrick J; Varma, Niraj

    2014-12-01

    Baseline QRS duration (QRSd) ≥150 ms is a recognized predictor of clinical improvement by cardiac resynchronization therapy (CRT), particularly for those with left bundle branch (LBBB). Patients with QRSd 52% below 10 Hz was especially predictive of response in those with QRSd <150 ms. In these patients, this power threshold was highly predictive of CRT response (positive predictive value 85.7%, negative predictive value 71.4%). In this group of CRT recipients with LBBB, retrospective analysis of QRS frequency content below 10 Hz had greater predictive value for CRT response than baseline QRSd, particularly in those with QRSd <150 ms. Copyright © 2014 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

  7. Experimental adaptation of wild-type canine distemper virus (CDV) to the human entry receptor CD150.

    Science.gov (United States)

    Bieringer, Maria; Han, Jung Woo; Kendl, Sabine; Khosravi, Mojtaba; Plattet, Philippe; Schneider-Schaulies, Jürgen

    2013-01-01

    Canine distemper virus (CDV), a close relative of measles virus (MV), is widespread and well known for its broad host range. When the goal of measles eradication may be achieved, and when measles vaccination will be stopped, CDV might eventually cross the species barrier to humans and emerge as a new human pathogen. In order to get an impression how fast such alterations may occur, we characterized required adaptive mutations to the human entry receptors CD150 (SLAM) and nectin-4 as first step to infect human target cells. Recombinant wild-type CDV-A75/17(red) adapted quickly to growth in human H358 epithelial cells expressing human nectin-4. Sequencing of the viral attachment proteins (hemagglutinin, H, and fusion protein, F) genes revealed that no adaptive alteration was required to utilize human nectin-4. In contrast, the virus replicated only to low titres (10(2) pfu/ml) in Vero cells expressing human CD150 (Vero-hSLAM). After three passages using these cells virus was adapted to human CD150 and replicated to high titres (10(5) pfu/ml). Sequence analyses revealed that only one amino acid exchange in the H-protein at position 540 Asp→Gly (D540G) was required for functional adaptation to human CD150. Structural modelling suggests that the adaptive mutation D540G in H reflects the sequence alteration from canine to human CD150 at position 70 and 71 from Pro to Leu (P70L) and Gly to Glu (G71E), and compensates for the gain of a negative charge in the human CD150 molecule. Using this model system our data indicate that only a minimal alteration, in this case one adaptive mutation, is required for adaptation of CDV to the human entry receptors, and help to understand the molecular basis why this adaptive mutation occurs.

  8. Experimental adaptation of wild-type canine distemper virus (CDV to the human entry receptor CD150.

    Directory of Open Access Journals (Sweden)

    Maria Bieringer

    Full Text Available Canine distemper virus (CDV, a close relative of measles virus (MV, is widespread and well known for its broad host range. When the goal of measles eradication may be achieved, and when measles vaccination will be stopped, CDV might eventually cross the species barrier to humans and emerge as a new human pathogen. In order to get an impression how fast such alterations may occur, we characterized required adaptive mutations to the human entry receptors CD150 (SLAM and nectin-4 as first step to infect human target cells. Recombinant wild-type CDV-A75/17(red adapted quickly to growth in human H358 epithelial cells expressing human nectin-4. Sequencing of the viral attachment proteins (hemagglutinin, H, and fusion protein, F genes revealed that no adaptive alteration was required to utilize human nectin-4. In contrast, the virus replicated only to low titres (10(2 pfu/ml in Vero cells expressing human CD150 (Vero-hSLAM. After three passages using these cells virus was adapted to human CD150 and replicated to high titres (10(5 pfu/ml. Sequence analyses revealed that only one amino acid exchange in the H-protein at position 540 Asp→Gly (D540G was required for functional adaptation to human CD150. Structural modelling suggests that the adaptive mutation D540G in H reflects the sequence alteration from canine to human CD150 at position 70 and 71 from Pro to Leu (P70L and Gly to Glu (G71E, and compensates for the gain of a negative charge in the human CD150 molecule. Using this model system our data indicate that only a minimal alteration, in this case one adaptive mutation, is required for adaptation of CDV to the human entry receptors, and help to understand the molecular basis why this adaptive mutation occurs.

  9. Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration.

    Science.gov (United States)

    Salhi, Hussam E; Hassel, Nathan C; Siddiqui, Jalal K; Brundage, Elizabeth A; Ziolo, Mark T; Janssen, Paul M L; Davis, Jonathan P; Biesiadecki, Brandon J

    2016-01-01

    Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphorylations can exhibit an expected or unexpected functional integration, whereby the function of two phosphorylations are different than that predicted from the combined function of each individual phosphorylation alone. We have shown that TnI Ser-23/24 and Ser-150 phosphorylation exhibit functional integration and are simultaneously increased in response to cardiac stress. In the current study, we investigated the functional integration of TnI Ser-23/24 and Ser-150 to alter cardiac contraction. We hypothesized that Ser-23/24 and Ser-150 phosphorylation each utilize distinct molecular mechanisms to alter the TnI binding affinity within the thin filament. Mathematical modeling predicts that Ser-23/24 and Ser-150 phosphorylation affect different TnI affinities within the thin filament to distinctly alter the Ca2+-binding properties of troponin. Protein binding experiments validate this assertion by demonstrating pseudo-phosphorylated Ser-150 decreases the affinity of isolated TnI for actin, whereas Ser-23/24 pseudo-phosphorylation is not different from unphosphorylated. Thus, our data supports that TnI Ser-23/24 affects TnI-TnC binding, while Ser-150 phosphorylation alters TnI-actin binding. By measuring force development in troponin-exchanged skinned myocytes, we demonstrate that the Ca2+ sensitivity of force is directly related to the amount of phosphate present on TnI. Furthermore, we demonstrate that Ser-150 pseudo-phosphorylation blunts Ser-23/24-mediated decreased Ca2+-sensitive force development whether on the same or different TnI molecule. Therefore, TnI phosphorylations can integrate across troponins along the myofilament. These data demonstrate that TnI Ser-23

  10. 150-nm mask fabrication using thin ZEP 7000 resist, GHOST, and dry etch for the MEBES 5000 pattern generator

    Science.gov (United States)

    Kim, Myung Y.; Lee, Jong-Hwa; Yoon, Young Jin; Choi, Boo-Yeon

    2000-07-01

    Advanced reticle specifications for critical dimension control (CD) and CD linearity of 150 nm generation devices requires significant improvements to the mask making process. ZEP 7000 is an e-beam resist that exhibits good contrast properties and acceptable dry etch resistance while maintaining superior lithographic quality. In this paper, an advanced process utilizing thin ZEP 7000 resist and ICP will be described. The combination of these two unit processes describes a factor space in mask making that is acceptable for the production of masks that meet the 150 nm ITRS roadmap requirements.

  11. Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration

    Directory of Open Access Journals (Sweden)

    Hussam E Salhi

    2016-12-01

    Full Text Available Troponin I (TnI is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphorylations can exhibit an expected or unexpected functional integration, whereby the function of two phosphorylations are different than that predicted from the combined function of each individual phosphorylation alone. We have shown that TnI Ser-23/24 and Ser-150 phosphorylation exhibit functional integration and are simultaneously increased in response to cardiac stress. In the current study, we investigated the functional integration of TnI Ser-23/24 and Ser-150 to alter cardiac contraction. We hypothesized that Ser-23/24 and Ser-150 phosphorylation each utilize distinct molecular mechanisms to alter the TnI binding affinity within the thin filament. Mathematical modeling predicts that Ser-23/24 and Ser-150 phosphorylation affect different TnI affinities within the thin filament to distinctly alter the Ca2+-binding properties of troponin. Protein binding experiments validate this assertion by demonstrating pseudo-phosphorylated Ser-150 decreases the affinity of isolated TnI for actin, whereas Ser-23/24 pseudo-phosphorylation is not different from unphosphorylated. Thus, our data supports that TnI Ser-23/24 affects TnI-TnC binding, while Ser-150 phosphorylation alters TnI-actin binding. By measuring force development in troponin-exchanged skinned myocytes, we demonstrate that the Ca2+ sensitivity of force is directly related to the amount of phosphate present on TnI. Furthermore, we demonstrate that Ser-150 pseudo-phosphorylation blunts Ser-23/24-mediated decreased Ca2+-sensitive force development whether on the same or different TnI molecule. Therefore, TnI phosphorylations can integrate across troponins along the myofilament. These data demonstrate

  12. Compositional Changes In Atmospheric Dust In Western United States During The Past 150 Years

    Science.gov (United States)

    Reynolds, R. L.; Goldstein, H.; Ketterer, M.; Moser, K.; Neff, J.; Reheis, M. C.; Rosenbaum, J. G.

    2009-12-01

    Dust emission in dryland regions is strongly influenced by human activity and landscape disturbance. The magnitude of such influence can be estimated by comparing dated geologic records that span times before and after human settlement. Chemical, magnetic, and textural studies of eolian dust, deposited in lakes or captured in natural subaerial traps, yield information about the influences of human activities on recent and contemporary dust composition compared to dust composition before settlement in mostly dryland western United States. Lake sediments in the Uinta Mountains (Utah), San Juan Mountains (Colorado), and Yellowstone National Park (Crevice Lake, Montana) have large shifts in chemistry within the top 15 cm that include the past ca. 150 years, from Pb-210 dating or varve chronology. Increased dust flux over this period is demonstrated by mass accumulation rates (San Juan Mountains) or implied by sedimentation rates (Uinta Mountains). In one lake, about 90 km east of Salt Lake City, many elements increase greatly above nearly constant background values that represent deposition over a few centuries prior to about AD 1850: Ag, by 4.0x; As, 4.2x; Cd, 5.3x; Co, 1.6x; Cu, 2.2x; Fe, 2.3x; Mo, 2.5x; Pb, 11.0x; Sb, 4.9x; Sn, 2.8x; W, 1.6x; Te, 5.3x; and Zn, 1.7x. Fly ash from coal combustion occurs in the upper 10 cm where S increases by 2.4x. In the other lakes, similar enrichments are evident over the past ca. 125-150 years for Ag, As, Cd, Cu, Pb, Sb, and Te. Stable isotopes of lead reveal widespread effects of anthropogenic sources. Increases in P in the Uinta and San Juan settings (4x and 8x, respectively) may be related to increases in eolian P deposition. Changes in dust composition also appear in fine-grained sediments on isolated bedrock surfaces that represent natural dust collectors, along a 700-km-long transect from the Mojave Desert to the Colorado Plateau. Sediment trapped in the upper 1-2 cm that likely represents dust from the past century, on the

  13. Bioequivalence evaluation of two formulations of fluconazole 150 mg capsule in healthy Arab men.

    Science.gov (United States)

    Al-Gaai, Eman; Lockyer, Marilyn; Al-Digither, Saleh; Hammami, Muhammad M

    2005-05-01

    A randomized crossover study was conducted on 26 healthy Arab males to compare the bioavailability of two formulations of fluconazole 150 mg capsules, Fluconazole (test) and Diflucan (reference). The formulations were administered after an overnight fast with a washout period of 2 weeks. Twenty blood samples (per period) were collected over 168 h, plasma fluconazole concentrations were determined by locally validated high performance liquid chromatography (HPLC) assay and pharmacokinetic parameters were analysed by the standard non-compartmental method. The mean +/- SD maximum concentration (C(max)), time to reach maximum concentration (T(max)), area under the curve (AUC(0-->t) and AUC(0-->infinity)) and elimination half-life (t(1/2)) were 3.17+/-0.47 and 3.24+/-0.59 microg/ml, 2.62+/-2.01 and 2.65+/-1.63 h, 149.52+/-29.49 and 151.36+/-25.84 microg.h/ml, 163.57+/-29.9 and 164.89+/-26.46 microg.h/ml, and 36.81+/-5.72 and 36.56+/-5.36 h for the test and reference drug, respectively. These values are similar to previously reported values in other ethnic groups. The parametric 90% confidence intervals on the mean of the difference (test-reference) between the log-transformed values of the two formulations were 95.484% to 101.035%, 96.382% to 101.245% and 94.621% to 102.074% for AUC(0-->t), AUC(0-->infinity) and C(max), respectively. The results indicate that the two formulations are equivalent in the rate and extent of absorption. Further, a review of the literature indicates that there is no apparent ethnic variation in the absorption and elimination rates of fluconazole. Copyright (c) 2005 John Wiley & Sons, Ltd.

  14. ON THE OCCASION OF THE 150TH ANNIVERSARY OF DARCY'S LAW

    Directory of Open Access Journals (Sweden)

    Kosta Urumović

    2005-12-01

    Full Text Available In the end of this year it will be a 150 years since Henry Philibert Gaspard Darcy (1803-1858 has performed first experiments which were a year after followed by publication of the famous monograph «Les fontaines publiques de la ville de Dijon» containing text Determination des lois d'ecoulement de l'eau à travers le sable. This work is fundamental because the basic law describing flow of liquid through the porous media is given therein. It describes the relation in which the double averaging of the flow velocity is introduced, and at the same time the theoretically correct energy approach to illustration of the groundwater flow is introduced. This law is without doubt the most important and the furthest reaching achievement of such exceptional scientist, who was both serious theoretician and also highly effective in practice. His scientific works are in a quite wide range – from water works to road building, and especially significant in hydrotechnics. Describing the wide scope and deep meaning of Darcy's law has remained an interesting subject even today. The "far sight" of Darcy's comprehension results from a simple fact – carefully performed and sharp-wittedly interpreted experiment. This gave the Darcy's law a theoretical clearness which allows its generalisation and extensions for various flow conditions in respect to the type of energy that controls the movement, type of liquid that flows and of the medium wherein the process takes place, also on the scale at which the process is studied. In this text, emphasis is primarily given to the results of original experiments and to the Darcy's original explanations of flow through the porous medium (the paper is published in Croatian.

  15. Changing mineral phase associated organic matter due to 150 years cultivation of a forest soil

    Science.gov (United States)

    Jakab, Gergely; Rieder, Ádám; Szalai, Zoltán

    2017-04-01

    Soil organic matter (SOM) is a key component that determines most properties of the soil. SOM is responsible for soil structure, porosity, fertility, cation exchange capacity, hydrological properties and puffer capacity. SOM is a heterogeneous mixture of organism derived molecules with various size and composition. Actual environmental circumstances affect SOM composition directly (flora, decomposition dynamics, tillage) and indirectly (climate, mineral composition of the soil, hydrological properties), however each clue of former environmental impacts is stored as well. Various SOM components are presumed to be located by different forces on different mineralogical particles. Present study aims to compare SOM quantity and composition of the same topsoil under different land uses. Soil under continuous forest is compared to the arable field where forest clearance was done 150 years before. Soil organic carbon (SOC) content of the arable soil decreased to 50% due to land use change, though aggregate stability did not change substantially. Under both land uses 80% of the bulk samples were found in aggregated form, while SOM within the aggregates was less polymerized under arable crops. On the other hand SOC content of the particulate organic matter fraction under arable crops increased. Based on the dynamic light scattering (DLS) results each individual SOM fraction has a polydispers distribution, that indicates the presence of the whole molecular size palette in each sample. Nevertheless some specific molecular size values such as 460 nm in case of arable land and 5500 nm in case of forest seemed to be predominant. DLS results were hardly comparable to those gained using photometric indexes because of the ambiguities. For more precise findings static light scattering method for molecular weight distribution is planned. G. Jakab was supported by the János Bolyai scholarship of the HAS, which is kindly acknowledged here.

  16. Neural coding of cooperative vs. affective human interactions: 150 ms to code the action's purpose.

    Directory of Open Access Journals (Sweden)

    Alice Mado Proverbio

    Full Text Available The timing and neural processing of the understanding of social interactions was investigated by presenting scenes in which 2 people performed cooperative or affective actions. While the role of the human mirror neuron system (MNS in understanding actions and intentions is widely accepted, little is known about the time course within which these aspects of visual information are automatically extracted. Event-Related Potentials were recorded in 35 university students perceiving 260 pictures of cooperative (e.g., 2 people dragging a box or affective (e.g., 2 people smiling and holding hands interactions. The action's goal was automatically discriminated at about 150-170 ms, as reflected by occipito/temporal N170 response. The swLORETA inverse solution revealed the strongest sources in the right posterior cingulate cortex (CC for affective actions and in the right pSTS for cooperative actions. It was found a right hemispheric asymmetry that involved the fusiform gyrus (BA37, the posterior CC, and the medial frontal gyrus (BA10/11 for the processing of affective interactions, particularly in the 155-175 ms time window. In a later time window (200-250 ms the processing of cooperative interactions activated the left post-central gyrus (BA3, the left parahippocampal gyrus, the left superior frontal gyrus (BA10, as well as the right premotor cortex (BA6. Women showed a greater response discriminative of the action's goal compared to men at P300 and anterior negativity level (220-500 ms. These findings might be related to a greater responsiveness of the female vs. male MNS. In addition, the discriminative effect was bilateral in women and was smaller and left-sided in men. Evidence was provided that perceptually similar social interactions are discriminated on the basis of the agents' intentions quite early in neural processing, differentially activating regions devoted to face/body/action coding, the limbic system and the MNS.

  17. Cervical spine alignment in the pediatric population: a radiographic normative study of 150 asymptomatic patients.

    Science.gov (United States)

    Abelin-Genevois, K; Idjerouidene, A; Roussouly, P; Vital, J M; Garin, C

    2014-07-01

    To describe the normal cervical sagittal alignment of the pediatric spine in a normal population and to identify the changes during growth period. We randomly selected in PACS database 150 full-spine standing views. Exclusion criteria were: age >18 years, spinal deformity and any disease affecting the spine (medical charts reviewing). For cervical alignment we measured: OC-angle according to Mc Gregor, C1C7 angle, upper cervical angle, inferior cervical angle and C7 tilt. Spino pelvic parameters were analyzed: T1 tilt, thoracic kyphosis, lumbar lordosis, pelvic incidence, sacral slope and pelvic tilt. We compared two age subgroups (juvenile and adolescent). Differences between age groups and gender were tested using Student's t test. Correlations between sagittal spinal parameters were evaluated using Pearson's test. Cervical spine shape was correlated to cranio cervical orientation to maintain horizontal gaze (r = 0.60) and to thoracic kyphosis (r = -0.46). Cervical spine alignment was significantly different between the two age groups except for the global C1C7 cervical lordosis, which remained stable. A significant gender difference was found for all the cervical sagittal angles (p < 0.01) whereas no differences were demonstrated for the spino pelvic parameters, except the lumbar lordosis (p = 0.047). This study is the first to report the cervical spinal alignment in a normal pediatric Caucasian population. Even though cervical lordosis is the common shape, our results showed variability in cervical sagittal alignment. Cervical spine is a junctional area that adjusts its alignment to the head position and to the underlying spinal alignment.

  18. A 150 year record of annual Bristlecone Pine 14C from the second millennium BC

    Science.gov (United States)

    Pearson, Charlotte; Salzer, Matthew; Brewer, Peter; Hodgins, Gregory; Jull, A. J. Timothy; Lange, Todd; Cruz, Richard; Brown, David; Boswijk, Gretel

    2017-04-01

    The Interdisciplinary Chronology of Civilizations Project (ICCP) at the University of Arizona (UA) aims to resolve longstanding chronological issues for Aegean and Near Eastern archaeology. A central component of this work is the production of annual resolution sequences of 14C from securely anchored tree-ring chronologies. Contemporary growth rings from Northern and Southern Hemisphere locations will be tested against a dataset of consecutive annual resolution 14C measurements from tree-rings of securely dated North American bristlecone pine (Pinus longaeva D.K. Bailey). These data will be used in a number of ways: to investigate potential issues with the current IntCal dataset due to interpolation, smoothing, or the inclusion of annual scale rapid changes in 14C; to identify 14C off-sets; to evaluate whether annual determinations of 14C present sufficient advantages for dating to justify the substantial costs involved in creating an annual resolution calibration curve; to explore whether the degree of reproducibility between species and growth locations justifies the construction of regional curves or allows us to pioneer 'annual resolution wigglematching' to anchor substantial floating tree-ring chronologies from Mediterranean archaeological contexts, and; if new rapid changes in 14C (aka 'spikes') are discovered, to use these to achieve this same goal. The initial focus of the project is the first and second millennium BC. From this period we present 150 annual 14C determinations from bristlecone pine and explore preliminary findings based on comparisons with the existing IntCal dataset, decadal data from the Mediterranean, and some contemporary years from Irish Oak (Quercus spp.) and New Zealand Kauri (Agathis australis (D. Don) Lindl.). This work, in combination with results from another UA project team (see abstract by Jull et al.) helps confirm the potential of the bristlecone pine archive for high resolution radiocarbon research.

  19. 150 Years of Coulomb Stress History Along the California-Nevada Border, USA.

    Science.gov (United States)

    Carena, S.; Verdecchia, A.

    2014-12-01

    The temporal and spatial correlation among earthquakes in diffuse plate boundary zones is not well understood yet. The region north of the Garlock fault between the Sierra Nevada and Death Valley is part of a diffuse plate boundary zone, which absorbs a significant fraction of the plate motion between Pacific and North America. This area has experienced at least eight Mw ≥ 6 earthquakes in historical times, beginning with the 1872 Mw 7.5 Owens Valley earthquake. Furthermore, since 1978 Long Valley caldera has been undergoing periods of unrest, with earthquake swarms and resurgence. Our goal is to determine whether the 1872 Owens Valley earthquake has influenced the seismicity and volcanic activity in the area. We model the evolution of coseismic, interseismic and postseismic Coulomb stress (ΔCFS) in the region due to both earthquakes and caldera activity in the last 150 years. Our results show that the 1872 Owens Valley earthquake strongly encourages faulting in northern Owens Valley. In addition, there is a correlation among smaller events, in the form of a west-to-east migration of earthquakes from Long Valley caldera toward the White Mountains immediately following the 1978 caldera inflation event. The last event in this sequence, the 1986 Mw 6.3 Chalfant Valley earthquake, controls the location of over 80% of its own aftershocks, which occur in areas of positive ΔCFS and reach Mw 5.7. We also calculate the cumulative ΔCFS on several major active faults in the region. Stresses up to 30 bars and 10 bars respectively have accumulated on the White Mountains (Central section) and Deep Springs faults, comparable to the expected stress drop in an average earthquake. Because no surface ruptures more recent than 1.8 ka have been identified on these faults [dePolo, 1989; Lee et al., 2001], we consider them as likely candidates for the next major earthquake in the region.

  20. RHIC 12x150A current lead temperature controller: design and implementation

    Energy Technology Data Exchange (ETDEWEB)

    Mi, C.; Seberg, S.; Ganetis, Hamdi, K.; Louie, W.; Heppner, G.; Jamilkowski, J.; Bruno, D.; DiLieto, A.; Sirio, C.; Tuozzolo, J.; Sandberg, J.; Unger, K.

    2011-03-28

    There are 60 12 x 150A current leads distributed in six RHIC service buildings; each lead delivers power supply current from room temperature to cryogenic temperature in RHIC. Due to the humid environment, condensation occurs frequently and ice forms quickly during operation, especially during an extensive storage period. These conditions generate warnings and alarms to which personnel must respond and establish temporary solutions to keep the machine operating. In here, we designed a temperature control system to avoid such situations. This paper discusses its design, implementation, and some results. There are six service buildings in the RHIC complex; each building has two valve boxes that transfer room-temperature current cables from the power supplies into superconducting leads, and then transport them into the RHIC tunnel. In there, the transition between the room-temperature lead into superconducting lead is critical and essential; smooth running during the physics store is crucial for the machine's continuing operation. One of the problems that often occurred previously was the icing of these current leads that could result in a potential leakage current onto ground, thereby preventing a continuous supply of physics store. Fig. 1 illustrates a typical example on a power lead. Among the modifications of the design of the valve box, we list below the new requirements for designing the temperature controller to prevent icing occurring: (1) Remotely control, monitor, and record each current lead's temperature in real time. Prevent icing or overheating of a power lead. (2) Include a temperature alarm for the high/low level threshold. In this paper we discuss the design, implementation, upgrades to, and operation of this new system.

  1. Immunoglobulin G subclass deficiency and infection risk in 150 patients with chronic lymphocytic leukemia.

    Science.gov (United States)

    Freeman, Jane A; Crassini, Kyle R; Best, O Giles; Forsyth, Cecily J; Mackinlay, Naomi J; Han, Ping; Stevenson, William; Mulligan, Stephen P

    2013-01-01

    Hypogammaglobulinemia is a common complication of chronic lymphocytic leukemia (CLL), but the significance of immunoglobulin G (IgG) subclass deficiency is unknown. We analyzed the prevalence of immunoglobulins G, A and M, IgG subclass deficiency and infection in 150 patients with CLL. Low IgG, IgA and IgM levels were observed in 27.3%, 30.7% and 56.7% of patients, respectively. IgG subclass deficiency was frequent, with reduced IgG1, IgG2, IgG3 and IgG4 in 28%, 19.3%, 52% and 22.7% of patients, respectively. IgG subclass deficiency (total 64.6%) and hypogammaglobulinemia (27.3%) were more prevalent than clinically significant infection (16%). Recurrent or significant infections were seen in 24 patients (16%), of whom 50% had hypogammaglobulinemia but 100% had at least one IgG subclass deficiency, indicating that half the patients with infection had IgG subclass deficiency but normal total IgG level. Deficiencies of IgG3 and IgG4 were statistically associated with infection risk. Normal immunoglobulin and IgG subclass levels were seen in 26 patients (17%) and none had infections. IgG subclass deficiency is commonly observed in patients with CLL with both normal and reduced total IgG levels, and is associated with infection. Screening patients with CLL for IgG subclass deficiency may be a useful adjunct in stratifying their infection risk.

  2. The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.

    Directory of Open Access Journals (Sweden)

    László Hackler

    Full Text Available C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against eight glioma cell lines at micromolar concentrations. Inhibition of cell proliferation by C-150 was mediated by affecting multiple targets as confirmed at transcription and protein level. C-150 effectively reduced the transcription activation of NFkB, inhibited PKC-alpha which are constitutively over-expressed in glioblastoma. The effects of C-150 on the Akt/ Notch signaling were also demonstrated in a Drosophila tumorigenesis model. C-150 reduced the number of tumors in Drosophila with similar efficacy to mitoxantrone. In an in vivo orthotopic glioma model, C-150 significantly increased the median survival of treated nude rats compared to control animals. The multi-target action of C-150, and its preliminary in vivo efficacy would render this curcumin analogue as a potent clinical candidate against glioblastoma.

  3. Immunogenicity of amino acids 1-150 of Streptococcus GapC displayed on the surface of Escherichia coli.

    Science.gov (United States)

    Song, Baifen; Yang, Xijing; Sun, Hunan; Yu, Liquan; Ma, Jinzhu; Wu, Zhijun; Cui, Yudong

    2017-04-01

    Streptococcus is one of the main pathogens that cause bovine mastitis. They includes into S.agalactiae, S.dysgalactiae, and S.uberis. The GapC protein is a virulence factor that is expressed on the surface of Streptococcus species. GapC is highly antigenic and immunization with GapC confers cross-protection against all three species. Our previous data showed that amino acids 1-150 of GapC (GapC 1-150 ) of S. dysgalactiae conferred similar immunoprotection compared to full-length GapC. Thus, the present study aimed to construct a recombinant Escherichia coli XL1-Blue strain that displayed GapC 1-150 on its surface, and to investigate the immunogenicity of the surface-localized GapC 1-150 . To do so, the ompA gene of the E. coli XL1-Blue strain was replaced with the lpp'-ompA-gapC1 1-150 or lpp'-ompA genes by λ Red recombination, the former of which fused GapC 1-150 to an Lpp lipoprotein signal peptide and amino acids 1-159 of OmpA; the recombinant strains were named XL1-Blue/LOG76 and XL1-Blue/LO11, respectively. GapC 1-150 was confirmed to localize to the surface of the XL1-Blue/LOG76 strain by an indirect enzyme-linked immunosorbent assay (ELISA), a fluorescence-activated cell sorter analysis, and laser-scanning confocal microscopy. Then, ICR mice were immunized intramuscularly with the XL1-Blue/LOG76 or XL1-Blue/LO11 strains, or recombinant GapC 1-150 . The sera of the immunized mice were collected and the anti-GapC 1-150 antibody levels were detected by ELISA. Lymphocytes secreting interleukin (IL)-4 and interferon-γ were detected by an enzyme-linked ImmunoSpot assay, as was the level of IL-17A level in the supernatant of cultured splenic lymphocytes. The mice immunized with the XL1-Blue/LOG76 strain or GapC 1-150 exhibited better cellular and humoral immunity. Lastly, the immunized mice were challenged with S. uberis, S. dysgalactiae, and S. agalactiae strains, and mice that were immunized with the XL1-Blue/LOG76 strain were better protected than those

  4. Prevention of Relapse in Reflux Esophagitis: A Placebo Controlled Study of Ranitidine 150 mg BID and 300 mg BID

    Directory of Open Access Journals (Sweden)

    John H Hegarty

    1997-01-01

    Full Text Available OBJECTIVE: To compare the efficacy and safety of long term use of ranitidine 150 mg bid, 300 mg bid and placebo in prevention of endoscopic and symptomatic relapse of reflux esophagitis in an international, double-blind, placebo controlled, parallel group study.

  5. Omeprazole (20 mg o.m.) versus ranitidine (150 mg b.d.) in duodenal ulcer healing and pain relief

    NARCIS (Netherlands)

    Mulder, C. J.; Tijtgat, G. N.; Cluysenaer, O. J.; Nicolai, J. J.; Meyer, W. W.; Hazenberg, B. P.; Vogten, A. J.; Gerrits, C.; Stuifbergen, W. H.

    1989-01-01

    The object of this double-blind, multicentre study was to compare duodenal ulcer healing rates after 2 to 4 weeks of treatment with either 20 mg omeprazole o.m. or 150 mg ranitidine b.d. One hundred and eighty-one patients were randomized: 91 received omeprazole and 90 received ranitidine. In a per

  6. Generalisation of 1:50k roads centrelines from 1:10k road polygons in an automated workflow

    NARCIS (Netherlands)

    Van Altena, V.; Van der Post, M.; Nijhuis, R.; Stoter, J.E.

    2013-01-01

    This paper reports about on going developments in the map production process of the Dutch Kadaster (who also hold the mapping agency). In March 2013, the Dutch Kadaster will produce the 1:50k map series fully automatically from 1:10k data for the first time. From that moment on, this new product

  7. Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1 and p150,95

    NARCIS (Netherlands)

    Keizer, G. D.; Borst, J.; Figdor, C. G.; Spits, H.; Miedema, F.; Terhorst, C.; de Vries, J. E.

    1985-01-01

    The human leukocyte function-associated (LFA-1) antigen, the monocyte differentiation antigen Mo-1 which is characterized as the C3bi receptor and the glycoprotein p150,95 are characterized biochemically. Immunoprecipitations carried out with 6 different monoclonal antibodies (mAb) against LFA-1

  8. 75 FR 11199 - 150th Meeting of the Advisory Council on Employee Welfare and Pension Benefit Plans; Notice of...

    Science.gov (United States)

    2010-03-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employee Benefits Security Administration 150th Meeting of the Advisory Council on Employee Welfare and Pension... Council on Employee Welfare and Pension Benefit Plans will be held on March 22, 2010. The session will...

  9. Initial thinning effects in 70- to 150-year-old Douglas-fir--western Oregon and Washington.

    Science.gov (United States)

    Richard L. Williamson; Frank E. Price

    1971-01-01

    Vigorous, mature (post-rotation age) Douglas-fir stands will probably exist for another 50 years or more on some properties in western Oregon and Washington. Intermediate harvests in the form of thinnings were analyzed on nine study areas ranging from 70 to 150 years old when thinned. Recoverable cubic-volume growth, averaging 81 percent of normal...

  10. Deposition and properties of silicon oxynitride films with low propagation losses by inductively coupled PECVD at 150 °C

    NARCIS (Netherlands)

    Rangarajan, B.; Kovalgin, Alexeij Y.; Schmitz, Jurriaan

    2013-01-01

    Silicon oxynitride films were deposited at 150 °C using inductively coupled plasma enhanced chemical vapor deposition, aiming towards low-temperature fabrication of waveguide material with low optical losses in the visible and near-infrared range. The influence of the deposition parameters such as

  11. A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning and memory

    NARCIS (Netherlands)

    Ostroveanu, Anghelus; Van der Zee, Eddy A.; Dolga, Amalia M.; Luiten, Paul G. M.; Eisel, Ulrich L. M.; Nijholt, Ingrid M.

    2007-01-01

    A-kinase anchoring proteins (AKAPs) form large macromolecular signaling complexes that specifically target cAMP-dependent protein kinase (PKA) to unique subcellular compartments and thus, provide high specificity to PKA signaling. For example, the AKAP79/150 family tethers PKA, PKC and PP2B to

  12. Low temperature basalt alteration by sea water: an experimental study at 70°C and 150°C

    Science.gov (United States)

    Seyfried, W.E.; Bischoff, J.L.

    1979-01-01

    Basaltic glass and diabase were reacted with seawater at 70°C at 1 bar and 150°C at 500 bars to determine fluid composition and alteration mineralogy. All experiments were performed at a water/ rock mass ratio of 10.

  13. 33 CFR 150.380 - Under what circumstances may vessels operate within the safety zone or area to be avoided?

    Science.gov (United States)

    2010-07-01

    ... N F C F Fishing, including bottom trawl (shrimping) N D P N Mobile drilling operations or erection...: OPERATIONS Vessel Navigation § 150.380 Under what circumstances may vessels operate within the safety zone or...—Movement of the vessel is permitted when cleared by the person in charge of vessel operations. D—Movement...

  14. Bioequivalence of two formulations of pregabalin 150-mg capsules under fasting conditions in healthy male subjects
.

    Science.gov (United States)

    Lee, Hyun A; Lee, SeungHwan; Yim, Sung-Vin; Kim, Bo-Hyung

    2017-02-01

    Pregabalin binds to the α2δ auxiliary subunit of voltage-gated calcium channels, which are widely distributed throughout the central and peripheral nervous systems and modulate calcium-dependent neurotransmitter release. Pregabalin is indicated for the treatment of peripheral and central neuropathic pain, partial seizures with or without secondary generalization, and treatment of generalized anxiety disorder (GAD). The purpose of this study was to assess the bioequivalence of two different formulations of pregabalin 150-mg capsules in healthy Korean male subjects under fasting conditions. This bioequivalence study was based on an open-label, single-dose, randomized, 2-period, 2-sequence crossover design with a washout period of 7 days. Blood samples for pharmacokinetic (PK) evaluation were collected up to 24 hours postdose. Plasma concentrations of pregabalin were determined using a validated LC-MS/MS method. PK parameters were determined using noncompartmental analysis. Bioequivalence was assumed if the 90% confidence intervals (CIs) for the test/reference ratios of log-transformed Cmax and AUClast values met the bioequivalence criteria specified by Korean regulatory guidelines (90% CI 0.8 - 1.25). The extent of exposure in terms of AUClast amounted to 26,018.3 - 3,580.8 µg×h/L for the test formulation and 25,680.2 ± 3,083.6 µg×h/L for the reference formulation. Cmax reached values of 4,782.7 ± 1,124.2 µg/L and 4,654.0 ± 911.4 µg/L for the test product and reference product, respectively. The geometric mean ratio and 90% CIs of the test product to the reference product were 1.0132 (0.9862 - 1.0351) for AUClast and 1.0153 (0.9351 - 1.1044) for Cmax, which were well within the range necessary to establish bioequivalence (90% CI 0.8 - 1.25). The bioequivalence between test and reference formulations under fasting conditions was confirmed both in terms of the rate and extent of absorption.
.

  15. Over 150 years of long-term fertilization alters spatial scaling of microbial biodiversity.

    Science.gov (United States)

    Liang, Yuting; Wu, Liyou; Clark, Ian M; Xue, Kai; Yang, Yunfeng; Van Nostrand, Joy D; Deng, Ye; He, Zhili; McGrath, Steve; Storkey, Jonathan; Hirsch, Penny R; Sun, Bo; Zhou, Jizhong

    2015-04-07

    Spatial scaling is a critical issue in ecology, but how anthropogenic activities like fertilization affect spatial scaling is poorly understood, especially for microbial communities. Here, we determined the effects of long-term fertilization on the spatial scaling of microbial functional diversity and its relationships to plant diversity in the 150-year-old Park Grass Experiment, the oldest continuous grassland experiment in the world. Nested samples were taken from plots with contrasting inorganic fertilization regimes, and community DNAs were analyzed using the GeoChip-based functional gene array. The slopes of microbial gene-area relationships (GARs) and plant species-area relationships (SARs) were estimated in a plot receiving nitrogen (N), phosphorus (P), and potassium (K) and a control plot without fertilization. Our results indicated that long-term inorganic fertilization significantly increased both microbial GARs and plant SARs. Microbial spatial turnover rates (i.e., z values) were less than 0.1 and were significantly higher in the fertilized plot (0.0583) than in the control plot (0.0449) (P microbial functional community structure, while soil geochemical variables contributed less. These results indicated that long-term agricultural practice could alter the spatial scaling of microbial biodiversity. Determining the spatial scaling of microbial biodiversity and its response to human activities is important but challenging in microbial ecology. Most studies to date are based on different sites that may not be truly comparable or on short-term perturbations, and hence, the results observed could represent transient responses. This study examined the spatial patterns of microbial communities in response to different fertilization regimes at the Rothamsted Research Experimental Station, which has become an invaluable resource for ecologists, environmentalists, and soil scientists. The current study is the first showing that long-term fertilization has

  16. Shock-adiabatic to quasi-isentropic compression of warm dense helium up to 150 GPa

    Science.gov (United States)

    Zheng, J.; Chen, Q. F.; Gu, Y. J.; Li, J. T.; Li, Z. G.; Li, C. J.; Chen, Z. Y.

    2017-06-01

    Multiple reverberation compression can achieve higher pressure, higher temperature, but lower entropy. It is available to provide an important validation for the elaborate and wider planetary models and simulate the inertial confinement fusion capsule implosion process. In the work, we have developed the thermodynamic and optical properties of helium from shock-adiabatic to quasi-isentropic compression by means of a multiple reverberation technique. By this technique, the initial dense gaseous helium was compressed to high pressure and high temperature and entered the warm dense matter (WDM) region. The experimental equation of state (EOS) of WDM helium in the pressure-density-temperature (P-ρ -T) range of 1 -150 GPa , 0.1 -1.1 g c m-3 , and 4600-24 000 K were measured. The optical radiations emanating from the WDM helium were recorded, and the particle velocity profiles detecting from the sample/window interface were obtained successfully up to 10 times compression. The optical radiation results imply that dense He has become rather opaque after the 2nd compression with a density of about 0.3 g c m-3 and a temperature of about 1 eV. The opaque states of helium under multiple compression were analyzed by the particle velocity measurements. The multiple compression technique could efficiently enhanced the density and the compressibility, and our multiple compression ratios (ηi=ρi/ρ0,i =1 -10 ) of helium are greatly improved from 3.5 to 43 based on initial precompressed density (ρ0) . For the relative compression ratio (ηi'=ρi/ρi -1) , it increases with pressure in the lower density regime and reversely decreases in the higher density regime, and a turning point occurs at the 3rd and 4th compression states under the different loading conditions. This nonmonotonic evolution of the compression is controlled by two factors, where the excitation of internal degrees of freedom results in the increasing compressibility and the repulsive interactions between the

  17. The GMRT 150 MHz all-sky radio survey. First alternative data release TGSS ADR1

    Science.gov (United States)

    Intema, H. T.; Jagannathan, P.; Mooley, K. P.; Frail, D. A.

    2017-02-01

    We present the first full release of a survey of the 150 MHz radio sky, observed with the Giant Metrewave Radio Telescope (GMRT) between April 2010 and March 2012 as part of the TIFR GMRT Sky Survey (TGSS) project. Aimed at producing a reliable compact source survey, our automated data reduction pipeline efficiently processed more than 2000 h of observations with minimal human interaction. Through application of innovative techniques such as image-based flagging, direction-dependent calibration of ionospheric phase errors, correcting for systematic offsets in antenna pointing, and improving the primary beam model, we created good quality images for over 95 percent of the 5336 pointings. Our data release covers 36 900 deg2 (or 3.6 π steradians) of the sky between -53° and +90° declination (Dec), which is 90 percent of the total sky. The majority of pointing images have a noise level below 5 mJy beam-1 with an approximate resolution of 25''×25'' (or 25''×25''/ cos(Dec-19°) for pointings south of 19° declination). We have produced a catalog of 0.62 Million radio sources derived from an initial, high reliability source extraction at the seven sigma level. For the bulk of the survey, the measured overall astrometric accuracy is better than two arcseconds in right ascension and declination, while the flux density accuracy is estimated at approximately ten percent. Within the scope of the TGSS alternative data release (TGSS ADR) project, the source catalog, as well as 5336 mosaic images (5°×5°) and an image cutout service, are made publicly available at the CDS as a service to the astronomical community. Next to enabling a wide range of different scientific investigations, we anticipate that these survey products will provide a solid reference for various new low-frequency radio aperture array telescopes (LOFAR, LWA, MWA, SKA-low), and can play an important role in characterizing the epoch-of-reionisation (EoR) foreground. The TGSS ADR project aims at

  18. Chromatin assembly factor 1, subunit A (P150 facilitates cell proliferation in human hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Xu M

    2016-07-01

    Full Text Available Meng Xu, Yuli Jia, Zhikui Liu, Linglong Ding, Run Tian, Hua Gu, Yufeng Wang, Hongyong Zhang, Kangsheng Tu, Qingguang Liu Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China Abstract: Several studies have revealed that the abnormal expression of chromatin assembly factor 1, subunit A (P150 (CHAF1A was involved in the development of some types of malignant tumors. However, CHAF1A expression and its role in hepatocellular carcinoma (HCC remain poorly characterized. In this study, we first investigated CHAF1A expression in six cell lines and 116 pairs of HCC and matched normal tumor-adjacent tissues to evaluate the clinicopathological characteristics of CHAF1A in HCC. Then, we detected the proliferation and apoptosis in HCC cells. In addition, a subcutaneous tumor model in nude mice was performed to evaluate tumor growth in vivo. We found that the expression of CHAF1A was significantly higher in HCC tissues than that in adjacent nontumor tissues (P<0.01. Clinical analysis indicated that CHAF1A expression was significantly correlated with the tumor–node–metastasis stage, tumor number, and tumor differentiation in HCC tissues (P<0.05, respectively. We also found that CHAF1A may potentially function as a poor prognostic indicator for 5-year overall and disease-free survival in patients with HCC (P<0.05, respectively. The elevated expression of CHAF1A was also observed in HCC cell lines compared with that in normal LO2 hepatic cell line (P<0.01. HCC cancer cells exhibited inhibition of cell growth, reduction in colony-formation ability, increased cell apoptosis rate, and impaired tumorigenicity in nude mice after CHAF1A knockdown. Collectively, we propose that CHAF1A by potentially mediating cancer cell proliferation plays an important role in promoting the development of HCC and may serve as a potential therapeutic target in HCC. Keywords: CHAF1A, hepatocellular

  19. A synthesis of marine sediment core δ13C data over the last 150 000 years

    Directory of Open Access Journals (Sweden)

    R. E. M. Rickaby

    2010-10-01

    Full Text Available The isotopic composition of carbon, δ13C, in seawater is used in reconstructions of ocean circulation, marine productivity, air-sea gas exchange, and biosphere carbon storage. Here, a synthesis of δ13C measurements taken from foraminifera in marine sediment cores over the last 150 000 years is presented. The dataset comprises previously published and unpublished data from benthic and planktonic records throughout the global ocean. Data are placed on a common δ18O age scale suitable for examining orbital timescale variability but not millennial events, which are removed by a 10 ka filter. Error estimates account for the resolution and scatter of the original data, and uncertainty in the relationship between δ13C of calcite and of dissolved inorganic carbon (DIC in seawater. This will assist comparison with δ13C of DIC output from models, which can be further improved using model outputs such as temperature, DIC concentration, and alkalinity to improve estimates of fractionation during calcite formation. High global deep ocean δ13C, indicating isotopically heavy carbon, is obtained during Marine Isotope Stages (MIS 1, 3, 5a, c and e, and low δ13C during MIS 2, 4 and 6, which are temperature minima, with larger amplitude variability in the Atlantic Ocean than the Pacific Ocean. This is likely to result from changes in biosphere carbon storage, modulated by changes in ocean circulation, productivity, and air-sea gas exchange. The North Atlantic vertical δ13C gradient is greater during temperature minima than temperature maxima, attributed to changes in the spatial extent of Atlantic source waters. There are insufficient data from shallower than 2500 m to obtain a coherent pattern in other ocean basins. The data synthesis indicates that basin-scale δ13C during the last interglacial (MIS 5e is not clearly distinguishable from the Holocene (MIS 1 or from MIS 5a and 5c, despite significant differences in ice volume and atmospheric CO2

  20. [Tomodensitometric image of the lumbar spine. Study of 150 patients hospitalized for discal sciatica].

    Science.gov (United States)

    Berthelot, J M; Guillot, P; Glémarec, J; Lopes, L; Bertrand-Vasseur, A; Maugars, Y; Prost, A

    1998-01-17

    There would be some discordance between patient expectations and expert recommendations concerning computed tomography (CT) of the spine for discal disorders. We analyzed patient opinion. At admission, a 25-item questionnaire was given to 150 patients hospitalized in a rheumatology unit for discal sciatica. Patients were asked to express their expectations concerning the CT exploration. Seventy percent of the patients had already undergone CT explorations requested by a general practitioner (55%) or a specialist (45%), 20% had had two CT explorations and 20% magnetic resonance imaging. Seventy-five percent felt they should have had a CT scan earlier, 85% thought a CT should be performed for back pain of less than one month duration and 96% in case of sciatica for 2 months or more. Patients felt their exploration came "late" because the physician was under financial pressure (52%), had incorrectly appreciated the patient's need (28%) or was incompetent in the matter (22%). Nevertheless, 15% of the patients recognized that the CT scan could be useless and 89% knew that all cases of hernia are not operable. Thirty percent recognized that hernias can go undetected on the CT scan and 78% that they may remain asymptomatic. Finally, 56% of the patients thought that the CT scan would not change their treatment and only 23% expected to undergo surgery sooner because of the CT exploration. Several factors would explain what patients expect from CT exploration of the spine: patient understanding that causes other than discal hernia can cause back pain (98%) or sciatic (77%); their fear of having another disorder (56% wanted to be reassured, which would explain in part why 27% hoped the CT would improve pain, 50% wanted to "see" their discal hernia, and 30 wanted to eliminate another cause of their pain); patient distrust of clinical diagnosis which they felt was less pertinent than CT (80% of the patients for generalists and 70% for specialists). Patient expectations did not

  1. Evaluation of cassette-based digital radiography detectors using standardized image quality metrics: AAPM TG-150 Draft Image Detector Tests.

    Science.gov (United States)

    Li, Guang; Greene, Travis C; Nishino, Thomas K; Willis, Charles E

    2016-09-08

    The purpose of this study was to evaluate several of the standardized image quality metrics proposed by the American Association of Physics in Medicine (AAPM) Task Group 150. The task group suggested region-of-interest (ROI)-based techniques to measure nonuniformity, minimum signal-to-noise ratio (SNR), number of anomalous pixels, and modulation transfer function (MTF). This study evaluated the effects of ROI size and layout on the image metrics by using four different ROI sets, assessed result uncertainty by repeating measurements, and compared results with two commercially available quality control tools, namely the Carestream DIRECTVIEW Total Quality Tool (TQT) and the GE Healthcare Quality Assurance Process (QAP). Seven Carestream DRX-1C (CsI) detectors on mobile DR systems and four GE FlashPad detectors in radiographic rooms were tested. Images were analyzed using MATLAB software that had been previously validated and reported. Our values for signal and SNR nonuniformity and MTF agree with values published by other investigators. Our results show that ROI size affects nonuniformity and minimum SNR measurements, but not detection of anomalous pixels. Exposure geometry affects all tested image metrics except for the MTF. TG-150 metrics in general agree with the TQT, but agree with the QAP only for local and global signal nonuniformity. The difference in SNR nonuniformity and MTF values between the TG-150 and QAP may be explained by differences in the calculation of noise and acquisition beam quality, respectively. TG-150's SNR nonuniformity metrics are also more sensitive to detector nonuniformity compared to the QAP. Our results suggest that fixed ROI size should be used for consistency because nonuniformity metrics depend on ROI size. Ideally, detector tests should be performed at the exact calibration position. If not feasible, a baseline should be established from the mean of several repeated measurements. Our study indicates that the TG-150 tests can be

  2. Numerical Investigation for the Plasma Coal Gasifier of 150kW and 1400kW

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hyeong Yeong; Suh, Jae Seung [Hannam University, Daejeon (Korea, Republic of); Lho, Tai Hyeop [National Fusion Research Institute, Daejeon (Korea, Republic of)

    2016-05-15

    This study has verification of simulation for the gasifier of 150kWe and focuses on prediction of performance for the gasifier of 1.4MWe with a computational fluid dynamics (CFD) method. It is possible to predict flow patterns, tracks of particles, combustion characteristics, temperature distributions and chemical distributions using the commercial CFD solver ANSYS/FLUENT. Integrated coal gasification combined cycle (IGCC) has gained a lot of interest because they can produce cleaner gaseous fuels such as hydrogen, carbon monoxide and methane. Therefore, the National Fusion Research Institute (NFRI) plant has been investigating the application of their plasma technology to gasify coal. It is a fusion plasma technology for better efficiency of low-carbon fuels. They recently completed experiment for the gasifier of 150kwe, and are currently trying experiment for the gasifier of 1.4MWe. They have tried to design the gasifier that has cold gases of a higher efficiency. However it is considerably complicated and expensive that performance of gasifier is experimentally studied, because it is difficult to measure or control gases of very high temperature. This study has numerical investigation for the phenomena of coal gasification for coal gasifier of 150kWe and 1.4MWe at experiment operating conditions. This study has verification of simulation for the gasifier of 150kWe, and predicts performance for the gasifier of 1.4MWe. The gasifier of 1.4MWe will have a cold gas of higher efficiency than gasifier of 150kWe because can generate many hydrogen gas. So this gasification has the potential to become cornerstone technology in many hydrogen industries.

  3. Climate and shoreline in Sweden during Weichsel and the next 150,000 years

    Energy Technology Data Exchange (ETDEWEB)

    Moren, L. [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Paasse, T. [Geological Survey of Sweden, Uppsala (Sweden)

    2001-08-01

    In this report scenarios of the climate, ice sheet and shoreline in Sweden during the Weichselian and the next 150,000 years are presented. The scenarios are intended to be used in performance and safety analysis of a deep geological repository, as a framework for the analysis of the impact of climate induced changes. First scenarios of the past and future climate are lined out. Based on these and observations of past ice sheets, scenarios of the evolution of the Scandinavian ice sheet are described. Finally the evolution of the shoreline is calculated using an empirical model based on observations from the Late Weichselian and the Holocene. There can be several causes of climate change. External causes are variation of solar radiation and dissipation of internal earth energy producing volcanism or shifts in earth physiography. Change in the internal dynamics of the climate system is another source of climate change. The concentration of different gases in the atmosphere affects the heat balance and the meteorological processes and thereby climate. Important for the climate are also the dynamics of ocean currents and ice sheets, albedo and biological processes. Changes of the earth orbit around the sun cause variations in the seasonal distribution and amount of solar radiation reaching the earth. Records of past climate show that there is a correlation between these variations and long-term climate changes. The theory that climate changes are triggered by variations in the earth orbital parameters is refereed to as the astronomical limate theory or the Milankowich theory. In spite of some ambiguities this theory is generally accepted. In this report results from three different models based on the astronomical climate theory are utilised. Simulations are compared to observations of past climate and ice sheets. The climate and ice sheet scenario for the Weichselian is based on deep-sea sediment data and a reconstruction of the Scandinavian ice sheet. The future

  4. Nd loaded liquid scintillator to search for {sup 150}Nd neutrinoless double beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Barabanov, I; Bezrukov, L; Yanovich, E [NR-RAS, Moscow (Russian Federation); Cattadori, C [INFN-Milano Bicocca, Milano (Italy); Danilov, N [IPC-RAS, Moscow (Russian Federation); Di Vacri, A; Ianni, A; Nisi, S [INFN-LNGS, L' Aquila (Italy); Ortica, F; Romani, A [Universita di Perugia and INFN Perugia, Perugia (Italy); Salvo, C [INFN-Genova, Genova (Italy); Smirnov, O [JINR, Dubna (Russian Federation)], E-mail: assunta.divacri@lngs.infn.it

    2008-11-01

    The {sup 150}Nd is considered one of the most attractive candidate for searching neutrinoless double beta (0{nu}{beta}{beta}-) decay, thanks to its high Q-value (3.367 MeV), that makes the external background issue less significative respect to other isotopes, and favorable computed matrix elements. The isotopic abundance of this isotope in natural neodimium is only 5.6% and up to now, it has been investigated only in low mass experiments. The next step is to increase the sensitivity of the experiments using larger mass of neodymium (10 ton-1 kton). This could be possible with a Nd loaded liquid scintillator (LS). At the Gran Sasso National Laboratory (LNGS), a joint INFN (Istituto Nazionale di Fisica Nucleare) and INR (Institute for Nuclear Research of Moscow) working group has been carrying out since 2001 an R and D activity aiming to develop organic liquid scintillators (LS) doped with metals. The achieved know-how and the satisfactory results obtained both with In and Gd allowed to face the development and production of Nd doped LS. The development of metal doped LS is challenging because the metal has to be embedded in a proper organic system that makes it soluble in an organic solvent minimizing the impact of the metal-organic compound on the optical and scintillation properties of the LS. A further challenge in the case of Nd is the presence of absorption bands of this element in the optical region with a transparent region around 400 nm, which is about at the maximum of the scintillator emission spectrum. A 2.5 1 Nd loaded LS has been produced diluting an originally developed Nd-Carboxylic (Nd-CBX) salt in pseudocumene (PC), the solvent of the Borexino liquid scintillator. The measured light yield, at [Nd] = 6.5 g/1 and [PPO] = 1.5 g/1, is {approx} 75% of pure PC at the same fluor concentration ({approx} 10000 ph/MeV). The Nd doped LS has been tested in a 2 1 quartz cell (wrapped by VM2000 reflector film) having dimensions 5x5x100 cm{sup 3}. The light

  5. Nd loaded liquid scintillator to search for 150Nd neutrinoless double beta decay

    Science.gov (United States)

    Barabanov, I.; Bezrukov, L.; Cattadori, C.; Danilov, N.; di Vacri, A.; Ianni, A.; Nisi, S.; Ortica, F.; Romani, A.; Salvo, C.; Smirnov, O.; Yanovich, E.

    2008-11-01

    The 150Nd is considered one of the most attractive candidate for searching neutrinoless double beta (0νββ-) decay, thanks to its high Q-value (3.367 MeV), that makes the external background issue less significative respect to other isotopes, and favorable computed matrix elements. The isotopic abundance of this isotope in natural neodimium is only 5.6% and up to now, it has been investigated only in low mass experiments. The next step is to increase the sensitivity of the experiments using larger mass of neodymium (10 ton-1 kton). This could be possible with a Nd loaded liquid scintillator (LS). At the Gran Sasso National Laboratory (LNGS), a joint INFN (Istituto Nazionale di Fisica Nucleare) and INR (Institute for Nuclear Research of Moscow) working group has been carrying out since 2001 an R&D activity aiming to develop organic liquid scintillators (LS) doped with metals. The achieved know-how and the satisfactory results obtained both with In and Gd allowed to face the development and production of Nd doped LS. The development of metal doped LS is challenging because the metal has to be embedded in a proper organic system that makes it soluble in an organic solvent minimizing the impact of the metal-organic compound on the optical and scintillation properties of the LS. A further challenge in the case of Nd is the presence of absorption bands of this element in the optical region with a transparent region around 400 nm, which is about at the maximum of the scintillator emission spectrum. A 2.5 1 Nd loaded LS has been produced diluting an originally developed Nd-Carboxylic (Nd-CBX) salt in pseudocumene (PC), the solvent of the Borexino liquid scintillator. The measured light yield, at [Nd] = 6.5 g/1 and [PPO] = 1.5 g/1, is ~ 75% of pure PC at the same fluor concentration (~ 10000 ph/MeV). The Nd doped LS has been tested in a 2 1 quartz cell (wrapped by VM2000 reflector film) having dimensions 5x5x100 cm3. The light propagates in the cell by total internal

  6. Investigation on damage sustained by a 150 kW pilot turbine ``The yellow widow`` situated at Nordvestjysk Folkecenter for Vedvarende Energi; Havariundersoegelse for 150 kW forsoegsmoelle, ``Den gule enke`` opstillet paa Nordvestjysk Folkecenter for Vedvarende Energi

    Energy Technology Data Exchange (ETDEWEB)

    1991-06-01

    An investigation of the damages sustained by a 150 kW pilot wind turbine which ran amok. The experienced gained will be used for new recommendations for certification of wind turbines in Denmark. Analyses of the damages based on interviews of witnesses, an analysis of data on the race, control measurements of the hydraulic system and simulations of the control system are presented in order to point out the causes of the damage. (CLS).

  7. A Wavelet-Modified ESPRIT Hybrid Method for Assessment of Spectral Components from 0 to 150 kHz

    Directory of Open Access Journals (Sweden)

    Luisa Alfieri

    2017-01-01

    Full Text Available Waveform distortions are an important issue in distribution systems. In particular, the assessment of very wide spectra, that include also components in the 2–150 kHz range, has recently become an issue of great interest. This is due to the increasing presence of high-spectral emission devices like end-user devices and distributed generation systems. This study proposed a new sliding-window wavelet-modified estimation of signal parameters by rotational invariance technique (ESPRIT method, particularly suitable for the spectral analysis of waveforms that have very wide spectra. The method is very accurate and requires reduced computational effort. It can be applied successfully to detect spectral components in the range of 0–150 kHz introduced both by distributed power plants, such as wind and photovoltaic generation systems, and by end-user equipment connected to grids through static converters, such as fluorescent lamps.

  8. Induced maturation of eel weighed 100–150 gram with PMSG, antidopamine, and 17α-methyltestosterone

    Directory of Open Access Journals (Sweden)

    Nadia Mega Aryani

    2015-10-01

    Full Text Available ABSTRACT Marketed eel Anguilla bicolor bicolor is commonly produced from larvae rearing activity whose broodstocks and larvae are caught from the nature. Supply of eel broodstock is restricted by its life cycle and uncertain size variation of mature male and female. This study was aimed to evaluate the effect of hormonal induction through injection to enhance masculinization and gonadal maturation of eel at the weight of 100–150 g. The experiment used completely random design with the use of combination pregnant mare serum gonadotropin  (PMSG, antidopamine (AD, dan 17α-methyltestosterone (MT, which were (10 IU/kg PMSG + 0,01 mg/kg AD, P2 (20 IU/kg PMSG + 0,01 mg/kg AD, P3 (10 IU/kg PMSG + 0,01 mg/kg AD + 150 µg/kg MT, P4 (20 IU/kg PMSG + 0,01 mg/kg AD + 150 µg/kg MT, and P5 (control; without hormonal treatment. The result showed that an increasing of fish length along with fish weight were performed by treatment P4 and P3. The highest gonadosomatic index value was obtained by treatment P3 (1,3030±0,24262. Based on gonadal histology analysis, 2nd phase of spermatogonia development was found in P3 in week-8. The highest testosterone level was obtained by treatment P3, followed by P4, P2, and P1 in week-4. Combination of 10 IU/kg PMSG + 0,01 mg/kg AD + 150 µg/kg MT could enhance masculinization and gonadal maturation of eel in eight weeks of rearing period. Keywords: gonadal maturation, Anguilla bicolor bicolor, PMSG, AD, MT  ABSTRAK Ikan sidat Anguilla bicolor bicolor yang dipasarkan pada umumnya merupakan hasil usaha pembesaran yang benih dan induknya masih diperoleh dari alam. Penyediaan induk ikan sidat terkendala dengan siklus hidup dan variasi perbedaan ukuran induk ikan sidat jantan dan betina matang gonad yang belum pasti. Penelitian ini bertujuan untuk mengkaji peran induksi hormonal yang disuntikkan pada ikan sidat dalam mempercepat proses pematangan gonad ikan sidat ukuran 100–150 g. Metode penelitian yang digunakan adalah

  9. Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging.

    Directory of Open Access Journals (Sweden)

    David Marcellin

    Full Text Available Cleavage of the full-length mutant huntingtin (mhtt protein into smaller, soluble aggregation-prone mhtt fragments appears to be a key process in the neuropathophysiology of Huntington's Disease (HD. Recent quantification studies using TR-FRET-based immunoassays showed decreasing levels of soluble mhtt correlating with an increased load of aggregated mhtt in the aging HdhQ150 mouse brain. To better characterize the nature of these changes at the level of native mhtt species, we developed a detection method that combines size exclusion chromatography (SEC and time-resolved fluorescence resonance energy transfer (TR-FRET that allowed us to resolve and define the formation, aggregation and temporal dynamics of native soluble mhtt species and insoluble aggregates in the brain of the HdhQ150 knock-in mouse. We found that mhtt fragments and not full-length mhtt form oligomers in the brains of one month-old mice long before disease phenotypes and mhtt aggregate histopathology occur. As the HdhQ150 mice age, brain levels of soluble full-length mhtt protein remain similar. In contrast, the soluble oligomeric pool of mhtt fragments slightly increases during the first two months before it declines between 3 and 8 months of age. This decline inversely correlates with the formation of insoluble mhtt aggregates. We also found that the pool-size of soluble mhtt oligomers is similar in age-matched heterozygous and homozygous HdhQ150 mouse brains whereas insoluble aggregate formation is greatly accelerated in the homozygous mutant brain. The capacity of the soluble mhtt oligomer pool therefore seems exhausted already in the heterozygous state and likely kept constant by changes in flux and, as a consequence, increased rate of insoluble aggregate formation. We demonstrate that our novel findings in mice translate to human HD brain but not HD patient fibroblasts.

  10. Bookmarks to the Celebration of the 150th Anniversary of the Discovery of the “Lake-Dwellings”

    Directory of Open Access Journals (Sweden)

    Marc-Antoine Kaeser

    2005-05-01

    Full Text Available Two years ago, the BHA (13/2: 22–23 announced the jubilee to be celebrated in 2004 for the 150th anniversary of the discovery of the Neolithic and Bronze Age “lake-dwellings”. This was an appropriate time to stress the significant role this field of inquiry has played in the methodological and epistemological development of prehistoric archaeology, from the second half of the 19th century up to present-day.

  11. YIELD AND QUALITY OF CHICORY (CICHORIUM INTYBUS L.) IN DEPENDENCE ON VARIETY AND FOLIAR APPLICATION OF ATONIK AND POLYBOR 150

    OpenAIRE

    IVAN ČERNÝ; VLADIMÍR PAČUTA; MAREK KOVÁR

    2009-01-01

    The influence of variety and foliar applications of Atonik and Polybor 150 on root yield and inulin content in root of chicory (Cichorium Intybus L.) plant were observed in field polyfactorial experiment. The field trials were established on experimental station Dolná Malanta in warm maize production area in 2005 and 2006 years. The root yield and inulin content were statistically high significantly influenced by year’s weather conditions. In term of obtained root yield and inulin content in ...

  12. YIELD AND QUALITY OF CHICORY (CICHORIUM INTYBUS L. IN DEPENDENCE ON VARIETY AND FOLIAR APPLICATION OF ATONIK AND POLYBOR 150

    Directory of Open Access Journals (Sweden)

    IVAN ČERNÝ

    2009-03-01

    Full Text Available The influence of variety and foliar applications of Atonik and Polybor 150 on root yield and inulin content in root of chicory (Cichorium Intybus L. plant were observed in field polyfactorial experiment. The field trials were established on experimental station Dolná Malanta in warm maize production area in 2005 and 2006 years. The root yield and inulin content were statistically high significantly influenced by year’s weather conditions. In term of obtained root yield and inulin content in root the combination of foliar preparations on variant B (Atonik: 0.4 l ha-1 in 2nd post-emergence herbicide application; Atonik + Polybor 150: 0.6 + 2.5 l ha-1 in 3rd post-emergence herbicide application; Polybor 150: 2.5 l ha-1 in 1st fungicide treatment was shown to be optimal in given agri-ecological conditions. Biological material affected the formation of yield parameters very differently. The highest yield of root was observed at variety Fredonia Nova and inulin content in root at variety Maurane (both statistically significant.

  13. 45 CFR 286.150 - Can a family, with a child under age 6, be penalized because a parent refuses to work because (s...

    Science.gov (United States)

    2010-10-01

    ... arrangements are unavailable. (b) Refusal to work when an acceptable form of child care is available is not... penalized because a parent refuses to work because (s)he cannot find child care? 286.150 Section 286.150... a parent refuses to work because (s)he cannot find child care? (a) If the individual is a single...

  14. Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1

    DEFF Research Database (Denmark)

    Poon, Anna Fong-Yee; Schmid, Benjamin; Pires, Carlota

    2016-01-01

    a familial AD patient carrying a L150P point mutation in PSEN1. Here we used CRISPR/Cas9 gene editing to correct for the single base pair mutation. This gene-corrected line, L150P-GC-hiPSC, serves as an isogenic control to the mutant line for future investigation of mechanisms and cellular phenotypes altered...

  15. The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling.

    Directory of Open Access Journals (Sweden)

    Inna Gordiienko

    Full Text Available Cell surface expression of CD150 and CD180 receptors in chronic lymphocytic leukemia (CLL associates with mutational IGHV status and favourable prognosis. Here we show a direct correlation between cell surface expression and colocalization of these receptors on CLL B cells. In the absence of CD150 and CD180 on the cell surface both receptors were expressed in the cytoplasm. The CD150 receptor was colocalized with markers of the endoplasmic reticulum, the Golgi apparatus and early endosomes. In contrast, CD180 was detected preferentially in early endosomes. Analysis of CD150 isoforms differential expression revealed that regardless of CD150 cell surface expression the mCD150 isoform with two ITSM signaling motifs was a predominant CD150 isoform in CLL B cells. The majority of CLL cases had significantly elevated expression level of the soluble sCD150, moreover CLL B cells secrete this isoform. CD150 or CD180 crosslinking on CLL B cells alone led to activation of Akt, mTORC1, ERK1/2, p38MAPK and JNK1/2 networks. Both CD150 and CD180 target the translation machinery through mTOR independent as well as mTOR dependent pathways. Moreover, both these receptors transmit pro-survival signals via Akt-mediated inhibition of GSK3β and FOXO1/FOXO3a. Unexpectedly, coligation CD150 and CD180 receptors on CLL B cells led to mutual inhibition of the Akt and MAPK pathways. While CD150 and CD180 coligation resulted in reduced phosphorylation of Akt, ERK1/2, c-Jun, RSK, p70S6K, S6RP, and 4E-BP; it led to complete blocking of mTOR and p38MAPK phosphorylation. At the same time coligation of CD150 and CD40 receptors did not result in Akt and MAPK inhibition. This suggests that combination of signals via CD150 and CD180 leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed.

  16. Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.

    Science.gov (United States)

    Rudrawar, Santosh; Kerry, Philip S; Rameix-Welti, Marie-Anne; Maggioni, Andrea; Dyason, Jeffrey C; Rose, Faith J; van der Werf, Sylvie; Thomson, Robin J; Naffakh, Nadia; Russell, Rupert J M; von Itzstein, Mark

    2012-11-21

    Novel 3-C-alkylated-Neu5Ac2en derivatives have been designed to target the expanded active site cavity of influenza virus sialidases with an open 150-loop, currently seen in X-ray crystal structures of influenza A virus group-1 (N1, N4, N5, N8), but not group-2 (N2, N9), sialidases. The compounds show selectivity for inhibition of H5N1 and pdm09 H1N1 sialidases over an N2 sialidase, providing evidence of the relative 150-loop flexibility of these sialidases. In a complex with N8 sialidase, the C3 substituent of 3-phenylally-Neu5Ac2en occupies the 150-cavity while the central ring and the remaining substituents bind the active site as seen for the unsubstituted template. This new class of inhibitors, which can 'trap' the open 150-loop form of the sialidase, should prove useful as probes of 150-loop flexibility.

  17. The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus.

    Directory of Open Access Journals (Sweden)

    Xinghong Dai

    2013-08-01

    Full Text Available Human cytomegalovirus (HCMV is a ubiquitous herpesvirus that causes birth defects in newborns and life-threatening complications in immunocompromised individuals. Among all human herpesviruses, HCMV contains a much larger dsDNA genome within a similarly-sized capsid compared to the others, and it was proposed to require pp150, a tegument protein only found in cytomegaloviruses, to stabilize its genome-containing capsid. However, little is known about how pp150 interacts with the underlying capsid. Moreover, the smallest capsid protein (SCP, while dispensable in herpes simplex virus type 1, was shown to play essential, yet undefined, role in HCMV infection. Here, by cryo electron microscopy (cryoEM, we determine three-dimensional structures of HCMV capsid (no pp150 and virion (with pp150 at sub-nanometer resolution. Comparison of these two structures reveals that each pp150 tegument density is composed of two helix bundles connected by a long central helix. Correlation between the resolved helices and sequence-based secondary structure prediction maps the tegument density to the N-terminal half of pp150. The structures also show that SCP mediates interactions between the capsid and pp150 at the upper helix bundle of pp150. Consistent with this structural observation, ribozyme inhibition of SCP expression in HCMV-infected cells impairs the formation of DNA-containing viral particles and reduces viral yield by 10,000 fold. By cryoEM reconstruction of the resulting "SCP-deficient" viral particles, we further demonstrate that SCP is required for pp150 functionally binding to the capsid. Together, our structural and biochemical results point to a mechanism whereby SCP recruits pp150 to stabilize genome-containing capsid for the production of infectious HCMV virion.

  18. Knockdown of Long Non-Coding RNA-ZFAS1 Protects Cardiomyocytes Against Acute Myocardial Infarction Via Anti-Apoptosis by Regulating miR-150/CRP.

    Science.gov (United States)

    Wu, Tao; Wu, Dan; Wu, Qinghua; Zou, Bing; Huang, Xiao; Cheng, Xiaoshu; Wu, Yanqing; Hong, Kui; Li, Ping; Yang, Renqiang; Li, Yunde; Cheng, Yingzhang

    2017-10-01

    ZFAS1 is one of cardiac-specific or cardiac-related lncRNAs. This study was to explore the functional involvement of ZFAS1 and its regulatory role in AMI. In this study, the models of AMI rat and myocardial cell cultured under hypoxia were made. The expression of ZFAS1 and miR-150 of myocardial infarction tissue or cardiac myocytes was determined by quantitative real time PCR. The regulatory role of ZFAS1 on miR-150 was examined by RNA pull down assay. The effect of miR-150 or ZFAS1 expression on cell viability was analyzed by MTT assay. The relative expression of ZFAS1 in the myocardium infracted zone and border zone was significantly upregulated at 1-48 h of AMI rats, but it downregulated at 1 week and 2 weeks; miR-150 was significantly downregulated at AMI-1-48 h and upregulated at 1 and 2 weeks after model establishment. The result of RNA pull down assay indicated that ZFAS1 could interact directly with miR-150. C-reactive protein (CRP) was regulated by ZFAS1/miR-150 axis and negatively targeted by miR-150. Hypoxia caused the decrease of cell viability and the upregulation of CRP at mRNA and protein levels; whereas this upregulation could be attenuated by miR-150 mimic or si-ZFAS1 in H9C2 cells and cardiomyocytes. Knockdown of ZFAS1 or miR-150 overexpression effectively relieved AMI-induced myocardial infarction in AMI-1 week rats. The ZFAS1/miR-150 axis was involved in the molecular mechanism of AMI induced cardiomyocytes apoptosis via regulating CRP. J. Cell. Biochem. 118: 3281-3289, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  19. Concept Design of Trailor Ferry Service to Carry 150 Trailers Between Jacksonville, FL and Bridgeport, CT of USA

    Science.gov (United States)

    Sindagi, S. C.; Sandhu, B. S.

    2015-04-01

    With the increased load on highways, today there is a need to develop alternate ways to transport goods within the sovereignty. The use of ships to transport goods has always been the primary method of transporting goods across the seas but it can also be used to transport goods within the country. This way we can reduce the load on highways which at this point of time serve as the primary method of transportation. Worldwide very few ferries are in operation which transports 100-150 Trailers between two ports. Catching on this opportunity for design, construction and operation of vessels, a survey for possible routes in United States of America which will transport 150 Trailers has been conducted by various authorities and organizations. The challenge here is to determine the parameters of the vessel and design a fleet of vessels that could carry trailers along with their tractors within the least possible time and in with least possible freight between Jacksonville, FL and Bridgeport, CT of United States of America. The primary aim of the work presented here is to propose a design with fleet in such a way that each day 150 trailers could be loaded and unloaded at each of the two mentioned ports. An analysis of the route between the ports brought out various primary parameters like the distance, weather, different load lines to be encountered and also several size constraints that the vessel needs to adhere to, in order to ply smoothly on this route. The vessel is designed as per the Guidelines for ships operating in international waters. The economic analysis of the project was performed spanning over 20 years and the best freight was found out which would be most profitable for the company as well as be a good value for money for the customers.

  20. Once daily maraviroc 300 mg or 150 mg in combination with ritonavir-boosted darunavir 800/100 mg.

    Science.gov (United States)

    Okoli, Chinyere; Siccardi, Marco; Thomas-William, Sathish; Dufty, Ngozi; Khonyongwa, Kirstin; Ainsworth, Jonathan; Watson, John; Cook, Roseanne; Gandhi, Kate; Hickinbottom, Geraldine; Owen, Andrew; Taylor, Stephen

    2012-03-01

    To describe the pharmacokinetics of maraviroc when dosed at 150 or 300 mg once daily with 800/100 mg of darunavir/ritonavir. A retrospective case-note review of HIV-infected adults taking maraviroc was conducted. Patients on a maraviroc-based regimen for a minimum of 5 weeks were grouped as receiving: (i) 300 mg of maraviroc twice daily with 245 mg of tenofovir/200 mg of emtricitabine; (ii) 300 mg of maraviroc once daily with 800/100 mg of darunavir/ritonavir once daily; and (iii) 150 mg of maraviroc once daily with 800/100 mg of darunavir/ritonavir once daily. C(trough) and C(peak) data were collected at 2, 12 or 24 h post-dose. Sixty-six patients were included, providing 115 samples. The median (IQR) C(peak) was 378 (350-640) ng/mL for 300 mg of maraviroc twice daily with 245 mg of tenofovir/200 mg of emtricitabine (n=9), 728 (378-935) ng/mL for 300 mg of maraviroc once daily with darunavir/ritonavir (n=29) and 364 (104-624) ng/mL for 150 mg of maraviroc once daily with darunavir/ritonavir (n=2; P=0.24). The median (IQR) C(trough) was 46 (33-61) ng/mL for 300 mg of maraviroc twice daily with 245 mg of tenofovir/200 mg of emtricitabine (n=12), 70 (49-97) ng/mL for 300 mg of maraviroc once daily with darunavir/ritonavir (n=34) and 43 (35-55) ng/mL for 150 mg of maraviroc once daily with darunavir/ritonavir (n=17; P=0.001). The maraviroc C(trough) in black patients (n=34) was 61 (45-110) ng/mL and in white patients (n=29) it was 49 (42-70) ng/mL (P=0.04). The C(peak) in black patients (n=20) was 800 (397-1060) ng/mL versus 387 (336-723) ng/mL in white patients (n=20; P=0.02). Once daily coadministration of 300 mg of maraviroc with 800/100 mg of darunavir/ritonavir was well tolerated and had favourable pharmacokinetics when compared with 300 mg of maraviroc twice daily with 245 mg of tenofovir/200 mg of emtricitabine. A 24% higher C(trough) and 107% higher C(peak) was seen in black patients compared with white patients.

  1. A portable Compton spectrometer for clinical X-ray beams in the energy range 20-150 keV

    Energy Technology Data Exchange (ETDEWEB)

    Vieira, A.A. [Departamento de Fisica, Pontificia Universidade Catolica de Sao Paulo (PUC-SP), Rua Marques de Paranagua, 111-01303-050 Sao Paulo, SP (Brazil); Linke, A. [Instituto de Fisica-Universidade de Sao Paulo, Rua do Matao, 187-Travessa R-05508-900 Sao Paulo, SP (Brazil); Yoshimura, E.M., E-mail: e.yoshimura@dfn.if.usp.b [Instituto de Fisica-Universidade de Sao Paulo, Rua do Matao, 187-Travessa R-05508-900 Sao Paulo, SP (Brazil); Terini, R.A., E-mail: rterini@pucsp.b [Departamento de Fisica, Pontificia Universidade Catolica de Sao Paulo (PUC-SP), Rua Marques de Paranagua, 111-01303-050 Sao Paulo, SP (Brazil); Instituto de Eletrotecnica e Energia-Universidade de Sao Paulo, Av. Prof. Luciano Gualberto, 1289-05508-900 Sao Paulo, SP (Brazil); Herdade, S.B., E-mail: sherdade@iee.usp.b [Instituto de Fisica-Universidade de Sao Paulo, Rua do Matao, 187-Travessa R-05508-900 Sao Paulo, SP (Brazil); Instituto de Eletrotecnica e Energia-Universidade de Sao Paulo, Av. Prof. Luciano Gualberto, 1289-05508-900 Sao Paulo, SP (Brazil)

    2011-02-15

    Primary beam spectra were obtained for an X-ray industrial equipment (40-150 kV), and for a clinical mammography apparatus (25-35 kV) from beams scattered at angles close to 90{sup o}, measured with a CdTe Compton spectrometer. Actual scattering angles were determined from the Compton energy shift of characteristic X-rays or spectra end-point energy. Evaluated contribution of coherent scattering amounts to more than 15% of fluence in mammographic beams. This technique can be used in clinical environments.

  2. Distance Protection Impedance Measurement for Inhomogeneous Multiple-Circuit 400/150 kV Transmission Lines with Shared Towers

    DEFF Research Database (Denmark)

    Bak, Claus Leth; Sigurbjörnsson, Ragnar; Bukh, Bjarne

    2016-01-01

    Combined transmission lines where different voltage levels shares same towers are used in transmission systems in order to save way of right. Faults between different voltage levels results in complex fault current distributions due to mutual couplings and the fact that the faulted phases no longer...... impedance for combined faults and thereby shed light on relay trips. This study uses actual fault records, analytical method and PSCAD simulation studies to analyse combined faults in an existing 400 and 150 kV transmission line owned by Danish TSO Energinet.dk. The results clearly show that an accurate...

  3. The Algebra Teacher's Guide to Reteaching Essential Concepts and Skills 150 Mini-Lessons for Correcting Common Mistakes

    CERN Document Server

    Muschla, Judith A; Muschla, Erin

    2011-01-01

    Easy to apply lessons for reteaching difficult algebra concepts Many students have trouble grasping algebra. In this book, bestselling authors Judith, Gary, and Erin Muschla offer help for math teachers who must instruct their students (even those who are struggling) about the complexities of algebra. In simple terms, the authors outline 150 classroom-tested lessons, focused on those concepts often most difficult to understand, in terms that are designed to help all students unravel the mysteries of algebra. Also included are reproducible worksheets that will assist teachers in reviewing and r

  4. Inter-comparison of High Energy Files (neutron-induced, from 20 to 150 MeV)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Young-Ouk; Fukahori, Tokio [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1998-11-01

    Recent new applications using accelerator-driven system require well-tested nuclear data when modeling the interaction of neutrons above 20 MeV. This work is aimed to review evaluation methods applied in currently available neutron high energy files above 20 to 150 MeV, to inter-compare their evaluated cross sections on some important isotopes, and to analyze resulting discrepancies. Through out these, integrities and consistencies of the high energy files are checked, applicability of physics models and evaluation methodologies are assessed, and some directions are derived to improve and expand current JENDL High Energy File. (author)

  5. Multi-frequency force-detected electron spin resonance in the millimeter-wave region up to 150 GHz

    Energy Technology Data Exchange (ETDEWEB)

    Ohmichi, E., E-mail: ohmichi@harbor.kobe-u.ac.jp; Tokuda, Y.; Tabuse, R.; Tsubokura, D.; Okamoto, T. [Graduate School of Science, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan); Ohta, H. [Molecular Photoscience Research Center, Kobe University, 1-1 Rokkodai-cho, Nada, Kobe 657-8501 (Japan)

    2016-07-15

    In this article, a novel technique is developed for multi-frequency force-detected electron spin resonance (ESR) in the millimeter-wave region. We constructed a compact ESR probehead, in which the cantilever bending is sensitively detected by a fiber-optic Fabry-Perot interferometer. With this setup, ESR absorption of diphenyl-picrylhydrazyl radical (<1 μg) was clearly observed at multiple frequencies of up to 150 GHz. We also observed the hyperfine splitting of low-concentration Mn{sup 2+} impurities(∼0.2%) in MgO.

  6. The high squareness Sm-Co magnet having Hcb=10.6 kOe at 150°C

    Science.gov (United States)

    Machida, Hiroaki; Fujiwara, Teruhiko; Kamada, Risako; Morimoto, Yuji; Takezawa, Masaaki

    2017-05-01

    The relationship between magnetic properties and magnetic domain structures of Sm(Fe, Cu, Zr, Co)7.5 magnet was investigated. The developed Sm-Co magnet, which is conducted homogenization heat treatment at ingot state, high temperature short time sintering and long time solid solution heat treatment showed the maximum energy product, [BH]m of 34.0 MGOe and the coercivity, Hcb of 11.3 kOe at 20°C respectively. Moreover, Hcb of 10.6 kOe at 150°C was achieved. Heat treated ingot has clear 1-7 phase in mother phase from optical microscope observation. Kerr effect microscope with magnetic field applied was used to investigate magnetic domain structure. Reverse magnetic domains were generated evenly but generation of them from inside grain were not observed. Cell structure was observed by scanning transmission electron microscope and composition analysis was conducted by energy dispersive X-ray spectroscopy. Cell size was approximately 150 ˜ 300 nm, Fe and Cu were clearly separated and concentrated to 2-17 phase and 1-5 phase respectively. Moreover, Cu concentration went up to 40 at% in 1-5 phase. That means the gap of domain wall energy between 1-5 phase and 2-17 phase was increased due to microstructure control by conducting heat treatment for compositional homogeneity.

  7. VizieR Online Data Catalog: LBDS-Lynx region GMRT 150-MHz obs. (Ishwara-Chandra+, 2010)

    Science.gov (United States)

    Ishwara-Chandra, C. H.; Sirothia, S. K.; Wadadekar, Y.; Pal, S.; Windhorst, R.

    2011-08-01

    It has been known for nearly three decades that high-redshift radio galaxies exhibit steep radio spectra, and hence ultrasteep spectrum radio sources provide candidates for high-redshift radio galaxies. Nearly all radio galaxies with z>3 have been found using this redshift-spectral index correlation. We have started a programme with the Giant Metrewave Radio Telescope (GMRT) to exploit this correlation at flux density levels about 10 to 100 times deeper than the known high-redshift radio galaxies which were identified primarily using the already available radio catalogues. In our programme, we have obtained deep, high-resolution radio observations at 150MHz with GMRT for several "deep" fields which are well studied at higher radio frequencies and in other bands of the electromagnetic spectrum, with an aim to detect candidate high-redshift radio galaxies. In this paper we present results from the deep 150-MHz observations of the LBDS-Lynx field (Leiden-Berkeley Deep Survey), which has been already imaged at 327, 610 and 1412MHz with the Westerbork Synthesis Radio Telescope and at 1400 and 4860MHz with the Very Large Array. (2 data files).

  8. Infection control consultation in a 150-bed acute care hospital: making this unobserved and unmeasured critical job function visible.

    Science.gov (United States)

    Grant, Patti S; Kim, Alex T

    2007-08-01

    One qualified infection control director, reporting directly to administration, was responsible for the Infection Prevention and Control Program of a 150-bed acute care, non-teaching, for-profit hospital. To observe for potential trending, questions (consultations) and determinations related to infectious processes were documented. To explore the possibility of measuring the essential although "hidden" function of the infection control consultation (process), which is a role not formerly linked to infection rates (outcomes). A 7-year retrospective study was conducted of all infection control consultations requiring more than a 5-minute intervention, as part of routine job responsibilities. The XmR Statistical Process Control charts (XmR Charts) and Pearson's Correlation Coefficient were used to analyze the activity of infection control consultations. From January 1, 1998 to December 31, 2004, there were 770 infection control consultations logged for 375.1 hours. Beginning with 2003, the variation in both the number and duration of infection control consultations in the XmR Charts become more standardized and has a smaller moving range between data points. The Pearson's Correlation Coefficient shows statistical significance (P control consultations at this 150-bed hospital illustrates that this essential component can be measured, and should be formerly tracked to document overall assessment of infection prevention and control interdisciplinary interaction. The consultation process became more efficient over the 7-year study period because, as the number of questions increased, the duration required to achieve closure decreased.

  9. The Emergency Medicine Events Register: An analysis of the first 150 incidents entered into a novel, online incident reporting registry.

    Science.gov (United States)

    Hansen, Kim; Schultz, Timothy; Crock, Carmel; Deakin, Anita; Runciman, William; Gosbell, Andrew

    2016-10-01

    Incident reporting systems are critical to understanding adverse events, in order to create preventative and corrective strategies. There are very few systems dedicated to Emergency Medicine with published results. All EDs in Australia and New Zealand were contacted to encourage the use of an Emergency Medicine - specific online reporting system called the Emergency Medicine Events Register (EMER). We conducted an analysis of the first 150 incidents entered into EMER. EMER captures Emergency-medicine-specific details including triage score, clinical presentation, outcome, contributing factors, mitigating factors, other specialities involved and patient journey stage. These details were analysed by an expert panel. Over the first 26 months, 150 incidents were reported into EMER. The most common categories reported, in order, were diagnostic error, procedural complication and investigation errors. Most incidents contained more than one category of error. The most common stage of the patient's journey in which an incident was detected was after discharge from the ED. A focus on correct diagnosis, procedure performance and investigation interpretation may reduce errors in the ED. The ability to learn from incidents and make system changes to enhance patient safety in healthcare organisations is an inherent part of providing a proactive, quality culture. © 2016 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.

  10. Ovarian follicle development and genital tract characteristics in different birthweight gilts at 150 days of age.

    Science.gov (United States)

    Almeida, Frcl; Alvarenga Dias, Aln; Moreira, L P; Fiúza, Atl; Chiarini-Garcia, H

    2017-10-01

    In the last decades, selection for improved prolificacy has resulted in higher litter sizes and has thereby increased the proportion of low birthweight (LW) piglets. It is well documented that LW piglets have lower growth performance, muscle accretion and poor carcass quality. However, little is known about the relations of birthweight with subsequent reproductive performance in gilts. This study investigated the effects of birthweight on reproductive tract and ovarian follicle development in 150-day-old gilts. Twenty eight female pigs of different birthweight ranges (high-HW: 1.8-2.2 kg; low-LW: 0.8-1.2 kg) from higher parity commercial sows were reared until 150 days of age, and their body weights were recorded at weaning, end of nursery and end of the grower-finisher phase. The animals were killed and their reproductive tracts collected for biometrical and histomorphometrical analysis. LW gilts showed significantly lower body weights and growth rates during all phases of production compared to their HW counterparts (p gilts. © 2017 Blackwell Verlag GmbH.

  11. The high squareness Sm-Co magnet having Hcb=10.6 kOe at 150°C

    Directory of Open Access Journals (Sweden)

    Hiroaki Machida

    2017-05-01

    Full Text Available The relationship between magnetic properties and magnetic domain structures of Sm(Fe, Cu, Zr, Co7.5 magnet was investigated. The developed Sm-Co magnet, which is conducted homogenization heat treatment at ingot state, high temperature short time sintering and long time solid solution heat treatment showed the maximum energy product, [BH]m of 34.0 MGOe and the coercivity, Hcb of 11.3 kOe at 20°C respectively. Moreover, Hcb of 10.6 kOe at 150°C was achieved. Heat treated ingot has clear 1-7 phase in mother phase from optical microscope observation. Kerr effect microscope with magnetic field applied was used to investigate magnetic domain structure. Reverse magnetic domains were generated evenly but generation of them from inside grain were not observed. Cell structure was observed by scanning transmission electron microscope and composition analysis was conducted by energy dispersive X-ray spectroscopy. Cell size was approximately 150 ∼ 300 nm, Fe and Cu were clearly separated and concentrated to 2-17 phase and 1-5 phase respectively. Moreover, Cu concentration went up to 40 at% in 1-5 phase. That means the gap of domain wall energy between 1-5 phase and 2-17 phase was increased due to microstructure control by conducting heat treatment for compositional homogeneity.

  12. Dominance of high-energy (>150 keV) heavy ion intensities in Earth's middle to outer magnetosphere

    Science.gov (United States)

    Cohen, Ian J.; Mitchell, Donald G.; Kistler, Lynn M.; Mauk, Barry H.; Anderson, Brian J.; Westlake, Joseph H.; Ohtani, Shinichi; Hamilton, Douglas C.; Turner, Drew L.; Blake, J. Bernard; Fennell, Joseph F.; Jaynes, Allison N.; Leonard, Trevor W.; Gerrard, Andrew J.; Lanzerotti, Louis J.; Allen, Robert C.; Burch, James L.

    2017-09-01

    Previous observations have driven the prevailing assumption in the field that energetic ions measured by an instrument using a bare solid state detector (SSD) are predominantly protons. However, new near-equatorial energetic particle observations obtained between 7 and 12 RE during Phase 1 of the Magnetospheric Multiscale mission challenge the validity of this assumption. In particular, measurements by the Energetic Ion Spectrometer (EIS) instruments have revealed that the intensities of heavy ion species (specifically oxygen and helium) dominate those of protons at energies ≳150-220 keV in the middle to outer (>7 RE) magnetosphere. Given that relative composition measurements can drift as sensors degrade in gain, quality cross-calibration agreement between EIS observations and those from the SSD-based Fly's Eye Energetic Particle Spectrometer (FEEPS) sensors provides critical support to the veracity of the measurement. Similar observations from the Radiation Belt Storm Probes Ion Composition Experiment (RBSPICE) instruments aboard the Van Allen Probes spacecraft extend the ion composition measurements into the middle magnetosphere and reveal a strongly proton-dominated environment at L≲6 but decreasing proton intensities at L≳6. It is concluded that the intensity dominance of the heavy ions at higher energies (>150 keV) arises from the existence of significant populations of multiply-charged heavy ions, presumably of solar wind origin.

  13. Lifetimes of superdeformed nuclei in the mass region A {approx}150 with the Eurogam multidetector array; Durees de vie de noyaux superdeformes de la region de masse A {approx}150 mesurees avec le multicompteur Eurogam

    Energy Technology Data Exchange (ETDEWEB)

    Savajols, H.

    1996-05-13

    This work concerns the study of the nuclear superdeformation phenomenon in the rare earth region (A {approx} 150). The superdeformed (SD) states in Gadolinium and Dysprosium isotopes were produced via heavy-ion induced reactions and studied with the (EUROGAM EUROpean GAmma-ray Microscope) gamma multidetector array. Precise level attenuation method (DSAM). From the derived quadrupole moments, we find large differences in deformation between the yrast bands in neighbour nuclei explained in terms of the case of nuclei corresponding to an axis ratio of 2:1, the shell gaps are not fixed at a specific particle number and deformation. Furthermore the present results indicate that the deformations associated with identical bands are different supporting the picture that mass and deformation changes tend to compensate in SB bands with the same moments of inertia. (author). 114 refs.

  14. Potentials and limitations of low-concentration contrast medium (150 mg iodine/ml) in CT pulmonary angiography

    Energy Technology Data Exchange (ETDEWEB)

    Radon, M.R., E-mail: mark.radon@gmail.co [Department of diagnostic Imaging, Northern General Hospital, Sheffield (United Kingdom); Kaduthodil, M.J.; Jagdish, J.; Matthews, S.; Hill, C.; Bull, M.J.; Morcos, S.K. [Department of diagnostic Imaging, Northern General Hospital, Sheffield (United Kingdom)

    2011-01-15

    Aim: To assess the feasibility of producing diagnostic multidetector computed tomography (MDCT) pulmonary angiography with low iodine concentration contrast media (150 mg iodine/ml) in patients with suspected acute pulmonary embolism. Materials and methods: Ninety-five randomized patients underwent MDCT (64 row) pulmonary angiography with 100 ml iopromide either at low concentration (LC) of 150 mg iodine/ml (n = 45) or high concentration (HC) of 300 mg iodine/ml (n = 50), delivered at the rate of 5 ml/s via a power injector. Two experienced radiologists, blinded to the concentration used, subjectively assessed the diagnostic quality and confidence using a four-point scale [1 = poor (not diagnostic), 2 = satisfactory, 3 = good, 4 = excellent]. Attenuation values (in HU) were measured in the main proximal branches of the pulmonary arteries. Results: The median diagnostic quality score for both observers was 3.5 (interquartile range 3-4) in the HC group and 2.5 (interquartile range 1.5-3) in the LC group (p < 0.01). The median diagnostic confidence score for both observers was 4 (interquartile range 3-4) in the HC group and 3 (interquartile range 1.5-4) in the LC group (p < 0.01). Both observers rated examinations as diagnostic in 69% of cases in the LC group, compared with 96% of cases in the HC group. Good interobserver agreement was found in both groups (K value 0.72 in the LC group and 0.73 in the HC). Obesity, poor scan timing, and dilution by venous return of non-opacified blood were the main reasons for a reduction in diagnostic quality of examinations in the LC group. Conclusion: Despite a 50% reduction of contrast medium dose in comparison to the standard technique, 150 mg iodine/ml can produce diagnostic MDCT pulmonary angiogram studies in the absence of obesity or high cardiac output and hyper-dynamic pulmonary circulation. Reducing the dose of contrast media would minimize the risk of contrast nephropathy in patients at risk of this complication

  15. Interoperability of 300 watt and 150 watt xenon arc solar simulators in sun protection factor and in UVA protection factor clinical testing.

    Science.gov (United States)

    Martinez, Alexa; Roberts, Glenn; Garzarella, Katherine; Lutz, Michael; Caswell, Michael

    2013-04-01

    The purpose of these clinical trials was to determine if 300 W and 150 W xenon arc solar simulators (SSs) deliver the same sun protection factor (SPF) and UVA protection factor (PFA). First, the SPF of the P7 control standard and of the P2 control standard was determined, testing 20 subjects using the method described in the Food and Drug Administration (FDA) Final Monograph and using 150 W and 300 W SSs. In the second clinical trial, the PFA of the Japanese Cosmetic Industry Association (JCIA) control standard and of the P2 control standard was determined, testing 10 subjects using the method described in the JCIA Technical Bulletin and using 150 W and 300 W SSs. The SPF values for P7 control standard determined using the 150 W and 300 W SSs were 4.54 ± 0.35 and 4.61 ± 0.32, respectively. The SPF values for P2 control standard determined using the 150 W and 300 W SSs were 17.0 ± 0.9 and 16.7 ± 0.9, respectively. The resultant PFA values for JCIA control standard determined using the 150 W and 300 W SSs were 4.06 ± 0.70 and 4.06 ± 0.70, respectively. The resultant PFA values for P2 control standard determined using the 150 W and 300 W SSs were 3.28 ± 0.25 and 3.44 ± 0.39, respectively. As the values are essentially identical for SPF and for PFA, the 150 W and 300 W SSs can be used interchangeably for SPF and PFA determinations. © 2013 John Wiley & Sons A/S.

  16. miR-184 and miR-150 promote renal glomerular mesangial cell aging by targeting Rab1a and Rab31.

    Science.gov (United States)

    Liu, Xiujuan; Fu, Bo; Chen, Dapeng; Hong, Quan; Cui, Jing; Li, Jin; Bai, Xueyuan; Chen, Xiangmei

    2015-08-15

    The molecular mechanism of kidney aging is not well understood, but the abnormal expression of miRNAs with aging is considered to be an important contributor. miR-184 and miR-150 were screened using a miRNA microarray and qRT-PCR and found to be significantly upregulated in 24-month-old rats. Rat renal primary glomerular mesangial cells (GMCs) were isolated from 3-month and 24-month-old rats for the in vitro analysis of the roles of miR-184 and miR-150 in kidney aging. Bioinformatics analyses suggested that Rab1a and Rab31, which are associated with cell autophagy, were targeted by both miR-184 and miR-150. miR-184 and miR-150 were increased significantly in aging GMCs versus young cells, while Rab1a and Rab31 were significantly lower in aging cells. Furthermore, dual luciferase reporter assays revealed that miR-184 and miR-150 bound to the 3'-UTR of Rab1a and Rab31 mRNAs. Transfection of miR-184 and miR-150 mimics into young GMCs suppressed the expression of Rab1a and Rab31. Transfected cells showed lower autophagy activities and higher levels of cellular oxidative products, leading to the aging of young GMCs. However, miR-184 and miR-150 inhibitors promoted autophagy and reduced oxidative damage by upregulating Rab1a and Rab31 in old GMCs. In conclusion, miR-184 and miR-150 inhibited autophagy, promoting GMC aging. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. 45 CFR 309.150 - What start-up costs are allowable for Tribal IV-D programs carried out under § 309.65(b) of this...

    Science.gov (United States)

    2010-10-01

    ... IV-D programs carried out under § 309.65(b) of this part? Federal funds are available for costs of... 45 Public Welfare 2 2010-10-01 2010-10-01 false What start-up costs are allowable for Tribal IV-D programs carried out under § 309.65(b) of this part? 309.150 Section 309.150 Public Welfare Regulations...

  18. Development of a Depleted Monolithic CMOS Sensor in a 150 nm CMOS Technology for the ATLAS Inner Tracker Upgrade

    CERN Document Server

    Wang, T.

    2017-01-01

    The recent R&D focus on CMOS sensors with charge collection in a depleted zone has opened new perspectives for CMOS sensors as fast and radiation hard pixel devices. These sensors, labelled as depleted CMOS sensors (DMAPS), have already shown promising performance as feasible candidates for the ATLAS Inner Tracker (ITk) upgrade, possibly replacing the current passive sensors. A further step to exploit the potential of DMAPS is to investigate the suitability of equipping the outer layers of the ATLAS ITk upgrade with fully monolithic CMOS sensors. This paper presents the development of a depleted monolithic CMOS pixel sensor designed in the LFoundry 150 nm CMOS technology, with the focus on design details and simulation results.

  19. Indication for a K/sup. pi. / = 0/sup -/ octupole band in /sup 150/Nd from electron scattering

    Energy Technology Data Exchange (ETDEWEB)

    Creswell, C.; Hirsch, A.; Bertozzi, W.; Heisenberg, J.; Kowalski, S.; Sargent, C.P.; Turchinetz, W.; Dieperink, A.

    1978-11-01

    Recent electron scattering results on the 0.850 MeV level of /sup 150/Nd, when analyzed in terms of the interacting boson model, are inconsistent with the interpretation of this level as a pure J/sup ..pi../(K) = 2/sup +/(0) state. Very recent (n,n'..gamma..) work has shown this level to be a 1/sup -/, 2/sup +/ doublet. Assuming this level to be the band head of a ''K/sup ..pi../ = 0/sup -/'' octupole band, a simple model is used to predict electron scattering form factors for the 0.850 MeV state and a 3/sup -/ octupole level observed at 0.931 MeV. Comparison is made between these predicted form factors and recent electron scattering data.

  20. A taxonomic survey of the shallow-water (<150 m black corals (Cnidaria: Antipatharia of the Hawaiian Islands

    Directory of Open Access Journals (Sweden)

    Daniel eWagner

    2015-05-01

    Full Text Available The shallow-water (<150 m antipatharian fauna of the Hawaiian Archipelago is described and illustrated based on a systematic examination of skeletal spine morphology, polyp morphology, colony branching pattern and in situ photographs. A total of 172 black coral specimens were examined, including all available type material of species previously reported from shallow waters off Hawaiʻi. The examined specimens were assigned to three families (Antipathidae, Aphanipathidae and Myriopathidae, six genera (Antipathes, Cirrhipathes, Stichopathes, Aphanipathes, Acanthopathes and Myriopathes, and eight species: Antipathes griggi Opresko, 2009, Antipathes grandis Verrill, 1928, Cirrhipathes cf. anguina (Dana, 1846, Stichopathes echinulata Brook, 1889, Stichopathes? sp., Aphanipathes verticillata mauiensis Opresko et al., 2012, Acanthopathes undulata (Van Pesch 1914 andMyriopathes cf. ulex (Ellis and Solander 1786. The biogeographical distribution of Hawaiian shallow-water black corals is presented and discussed.