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Sample records for tep au fdg

  1. Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG ...

    African Journals Online (AJOL)

    Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG. Guensi Amal, Taleb Sara, Cherkaoui Salhi Ghofrane, Ait Idir Malika, Houjami Majdouline, Sahraoui Souha, Benider Abdelatif, Touil Najoua, Benmoussa Ghita, Baroudi Zineb, Chikhaoui Nabil ...

  2. PET/T.D.M. with {sup 18}FDG in the vesicle tumors; TEP/TDM au {sup 18}FDG dans les tumeurs vesicales

    Energy Technology Data Exchange (ETDEWEB)

    De Clermont-Gallerande, H.; Laffon, E.; Allard, M.; Fernandez, P. [Universite Victor-Segalen Bordeaux-2, (France); Godbert, Y. [service de medecine nucleaire, pole d' imagerie, CHRU de Bordeaux, (France); Wallerand, H. [service d' urologie, pole de chirurgie, CHRU de Bordeaux, (France); Ravaud, A. [service d' oncologie medicale et radiotherapie, pole d' oncologie, CHRU de Bordeaux, (France)

    2009-05-15

    The aim of this study was to evaluate the PET/T.D.M. with 18 F.D.G. with a hyper diuresis protocol in the initial evaluation of the vesicle tumors. After results, it appears that the PET/T.D.M. with 18 F.D.G. has an excellent diagnosis performance in the evaluation of vesicle tumors and could have a prognosis interest. These results are to be confirmed. (N.C.)

  3. F.D.G. PET role in the management of refractory epilepsy; Place de la TEP au FDG dans le bilan des epilepsies pharmacoresistantes

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    Papathanassiou, D.; Domange-Testard, A.; Bruna-Muraille, C.; Cuif-Job, A.; Liehn, J.C. [Institut Jean-Godinot, Service de Medecine Nucleaire, 51 - Reims (France); Thiriaux, A. [CHU de Reims, Service de Neurologie, 51 - Reims (France); Motte, J. [CHU de Reims, Service de Pediatrie, 51 - Reims (France)

    2009-06-15

    The work-up of drug-resistant partial epilepsy is intended to localize epileptogenic foci in the purpose of a possible surgery. We aimed to assess the role of fluorodeoxyglucose Positron Emission Tomography (F.D.G. PET) in this scope. This study involved 34 patients who underwent brain F.D.G. PET, with a final diagnosis in 21. The value of F.D.G. PET for lateralization and localisation of the epileptogenic focus was evaluated by a blinded interpretation, and compared with the value of standard investigations. The impact of F.D.G. PET was assessed by the means of questions intended for the neurologist in each case. All the epilepsy types together, F.D.G. PET lateralized and localised the foci in 65 and 47% of the 34 subjects respectively. Among the 19 subjects with final diagnosis (patients with bilateral foci excluded), lateralization was correct in 84% and localisation in 63% (and the values were greater for temporal epilepsy than for extra temporal foci). PET frequently provided additional information compared with MRI, but not with EEG. F.D.G. PET was useful in 82.5% of cases (confirming management in 65% and changing it in 17.5% of the patients). Our experience corroborated the value of F.D.G. PET for lateralization and localisation of epileptogenic foci, and its role in case of normal MRI. However, F.D.G. PET appears as a confirmation tool rather than an examination resulting in a change in management rate. (authors)

  4. Use of lasilix to explore pelvis pathologies in F.D.G. PET; Utilisation du lasilix pour l'exploration des pathologies pelviennes en TEP au FDG

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    Bruna-Muraille, C.; Papathanassiou, D.; Cuif-Job, A.; Moussa-Bouharati, K.; Guedec-Ghelfi, R.; Liehn, J.C. [Institut Jean-Godinot, 51 - Reims (France)

    2010-07-01

    Purpose: F.D.G. accumulations in ureters and bladder can be annoying to interpret PET examinations in case of pelvis pathology, especially for uterine cervix tumors and for some ganglions localizations. The aim of this study was to confirm that the injection of furosemide before F.D.G. scintigraphy leads to a noticed concentration reduction of the tracer in urine, what can allow a better analysis of pelvis pathology and to evaluate the possibility of using this technique in practice. Conclusions: the Lasilix injection before a PET with F.D.G. in patients suffering of a pelvis pathology allows a noticed reduction of urine intensity, making easier the interpretation for a number of pelvic disorders. however, on 26 studied patients, 3 presented urged incontinence during examination, that poses a limitation of the technique and requires the selection, when a prior medical examination, of patients susceptible to receive this protocol. (N.C.)

  5. Usefulness of {sup 18}FDG-PET in epilepsy. Methods and indications; Utilite de la TEP au {sup 18}FDG dans l'epilepsie. Methodes et indications

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    Chassoux, F. [Centre hospitalier Sainte-Anne, 1, rue Cabanis, 75014 Paris, (France); Service hospitalier Frederic-Joliot, I2BM-CEA, 4, place du General Leclerc, 91401 Orsay cedex, (France)

    2009-05-15

    Positron emission tomography (PET) using 18-fluorodeoxyglucose ({sup 18}FDG) is currently used in pre surgical work-up for drug-resistant partial epilepsies in children as in adults, in addition to MRI. Recent cameras with less than 5 mm spatial resolution allow to obtain thin slices (about 2 mm thickness) in 3D planes. {sup 18}FDG is intravenously injected at the mean dose of 3 MBq/kg of body weight in inter-ictal and resting state, in a quiet, dimly lit environment and careful monitoring for head movements and ictal events. In children, sedation may be necessary. Image acquisition starts 30 min after injection and ended 15 to 20 min later. Semiquantitative analysis is visually assessed in clinical practice using colour scales. PET sensibility is improved by superimposition of metabolic imaging on MRI. Statistical analysis with S.P.M. may be useful but comparison with health subjects database is required. In medial temporal lobe epilepsy associated with hippocampal sclerosis, hypo metabolism ipsilateral to the epileptogenic focus is found in 70 to 90% of the cases and is predictive of surgical outcome. In other types of temporal and extra temporal epilepsy with negative MRI, focal hypo metabolism can be detected, allowing identification of minor gyral abnormalities corresponding to focal cortical dysplasia. In such MRI negative cases, PET findings may improve surgical outcome. (author)

  6. Interest of PET with F.D.G. in the follicular lymphomas; Interet de la TEP au FDG dans les lymphomes folliculaires

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    Albarghach, N.; Cornec, D.; Querellou, S.; Berthou, C.; Renaudineau, Y.; Pradier, O.; Cheze-Lerest, C. [CHU Morvan, 29 - Brest (France); Hatt, M.; Visvikis, D. [Inserm U650, 29 - Brest (France)

    2009-10-15

    For the follicular lymphomas, the PET is not in the systematic medical evaluation when it cannot be ignored in the evaluation of high grade non hodgkin lymphomas because it allows to make a complete extension evaluation and especially to help to define the target volume when the radiotherapy is indicated. The fixation of F.D.G. in follicular lymphomas was studied. We showed that the follicular lymphomas present in PET under the form of hypermetabolic injuries. It seems possible to consider the use of PET to help at the definition of target volumes when the radiotherapy is indicated. The intensity of fixation seems to have a predictive value for the therapy response in case of immunotherapy. The measurement of the active tumoral volume seems to have a predictive value for the response to the treatment that is worth being specified on a more important population. (N.C.)

  7. Clinical use of sentinel node (SN) mapping and {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (TEP) in the management of cutaneous melanoma; Detection isotopique du ganglion sentinelle (GS) et tomographie d'emission de positons au {sup 18}F-fluorodeoxyglucose (TEP - FDG) proposition d'une strategie d'utilisation dans les melanomes

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    Courbon, F. [Centre Hospitalier Universitaire, CLCC, Oncologie Nucleaire, Service de Medecine Nucleaire, 31 - Toulouse (France); Chevreau, C. [Institut Claudius Regaud, Service d' Oncologie Medicale, 31 - Toulouse (France)

    2005-07-15

    In France, there is a new case of melanoma for 10.000 inhabitants per year. This incidence has doubled in 10 years. Surgery of the primary site is the main treatment of this disease: however thanks to the concept of sentinel node (SN) the management of melanoma changes, it tends to include adjuvant treatments. Because of the isotopic detection of SN and the use of PET FDG, nuclear medicine plays a key role in melanoma. This paper aims to discuss the place of isotopic SN mapping and TEP FDG in clinical practice. (authors)

  8. Positron computed tomography with fluorodeoxyglucose; TEP FDG

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    Hervouet, T.; Kraeber-Bodere, F.; Lamy, T.; Le Gouil, S.; Devillers, A.; Bodet-Milin, C.; Ansquer, C.; Cheze-le Rest, C.; Metges, J.P.; Teyton, P.; Lozach, P.; Volant, A.; Bizais, Y.; Visvikis, D.; Morel, O.; Girault, S.; Soulie, P.; Dupoiron, D.; Berthelot, C.; Lorimier, G.; Jallet, P.; Garin, E.; Prigent, F.; Lesimple, T.; Barge, M.L.; Rousseau, C.; Devillers, A.; Bernard, A.M.; Bouriel, C.; Bridji, B.; Resche, R.; Banayan, S.; Claret, M.; Ninet, J.; Janier, M.; Billotey, C.; Garin, E.; Devillers, A.; Becker, S.; Lecloirec, J.; Boucher, E.; Raoul, J.L.; Rolland, V.; Oudoux, A.; Valette, F.; Dupas, B.; Moreau, P.; Champion, L.; Anract, P.; Wartski, M.; Laurence, V.; Goldwasser, F.; Pecking, A.P.; Alberini, J.L.; Brillouet, S.; Caselles, O.; Allal, B.; Zerdoud, S.; Gansel, M.G.; Thomas, F.; Dierrickx, L.; Delord, J.P.; Marchand, C.; Resche, I.; Mahe, M.A

    2006-09-15

    Several oral communications present the interest of positron computed tomography with fluorodeoxyglucose in the detection of cancers, or for the follow up of cancers treatments in order to detect early possible relapses.PET FDG is also used to optimize the definition of target volume in order to avoid side effects and to get a better control of the illness. (N.C.)

  9. Positron Emission Tomography and head and neck cancers: Recurrence and post-treatment surveillance; TEP au {sup 18}-FDG et cancers ORL: recidive et surveillance post-therapeutique

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    Colavolpe, C.; Guedj, E.; Tessonnier, L.; Mundler, O. [CHU La Timone, Service Central de Biophysique et de Medecine Nucleaire, 13 - Marseille (France); Fakhry, N.; Zanaret, M. [CHU La Timone, Service d' ORL et de Chirurgie Cervicofaciale, 13 - Marseille (France)

    2008-08-15

    Recurrence of head and neck squamous cell carcinomas occurs early and currently, with poor prognosis. Post-therapeutic surveillance aims to diagnose a recurrence as early as possible in order to perform curative salvage therapy. The risk of recurrence is highest in locally advanced cancers. Morphological imaging, including Computed Tomography (CT Scan) and magnetic resonance imaging, can be limited by the anatomic changes following surgery and radiotherapy, and sometimes cannot provide early diagnosis of recurrence. Histology presents some risk of morbidity, especially in irradiated tissues, and sampling error. Positron Emission Tomography (PET) with {sup 18}F-fluorodeoxyglucose (F.D.G.) is superior to conventional imaging for the diagnosis and staging of recurrence, especially when it is performed three months after the end of treatments. F.D.G.-PET has high sensitivity and negative predictive value for recurrence, so that further morphological and invasive investigations should not be performed in case of negative examination. On the other hand, because of its limited specificity and positive predictive value, any positive PET finding should be documented, in order to avoid false positives findings. The diagnosis of recurrence is the field of application in which F.D.G.-PET has the greatest impact on head and neck cancer management: it is considered as a standard. However, the interest of F.D.G.-PET during systematic follow-up has not yet been confirmed. PET should only be performed in difficult cases and within evaluation protocols. (authors)

  10. Evaluation of the PET/CT with F.D.G. in the masculine fertility evaluation; Evaluation de la TEP/TDM au FDG dans l'evaluation de la fertilite masculine

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    Dierickx, L.O.; Zerdoud, S.; Brillouet, S.; Filleron, T.; Caselles, O. [Institut Claudius-Regaud, 31 - Toulouse (France); Huyghe, E.; Courbon, F. [Centre hospitalier universitaire de Rangeuil, 31 - Toulouse (France); Plante, P. [Centre hospitalier universitaire Paule de Viguier, 31 - Toulouse (France); Bujan, L.

    2010-07-01

    Purpose: the contribution of a functional imaging examination is expected by the andrology and urology community in the situations of masculine infertility (especially after chemotherapy). The spermatogonia, responsible of cells populations renewal, catch the F.D.G. tracer through GLUT3 receptors. To date, PET/CT with F.D.G. has never been used for functional study of testes with andrology aim. The objective is to search an eventual correlation between the F.D.G. testes uptake and spermatology examination. Conclusions: This preliminary study shows that among men without any known testes pathology, there is a significant correlation between the F.D.G. testes uptake and the principal parameters of masculine fertility. If these results are confirmed, clinical applications could appear in the diagnosis and prognosis exploration of hypo fertility. (N.C.)

  11. Value of delayed [{sup 18}F]-FDG-PET for brain tumors detection; Interet de la TEP au [{sup 18}F]-FDG double phase avec acquisition tardive dans la detection des tumeurs cerebrales

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    Vermeere, V.; Burg, S. [Centre Eugene-Marquis, Service de Medecine Nucleaire, 35 - Rennes (France); Wager, M. [Centre Hospitalier Universitaire de Poitiers, Service de Medecine Nucleaire et Biophysique, 86 - Poitiers (France); Perdrisot, R. [Centre Hospitalier Universitaire de Poitiers, Service de Neurochirurgie, 86 - Poitiers (France)

    2007-05-15

    The value of FDG-PET remains controversial in the study of brain tumors because of the high FDG uptake in gray matter. The aim of this study was to evaluate the utility of {sup 18}FDG-PET delayed acquisitions in the distinction of brain tumors from the cortex. Thirty patients with cerebral tumors were included, 25 high-grade tumors and five low grade. Two FDG-PET acquisitions, early (1 h), and delayed (5 h). were performed. On the delayed images. two types of three-dimensional regions of interest (ROI) were drawn using a Bayesian segmentation based on a Poisson law, the lesion ROI, specific (LS) and total (LT), and the ROI of references, on the healthy hemi-cortex (SG) and on the healthy white matter (SB). These ROI were reported on the early images. The evolution of the visualization of the lesions was appreciated using a qualitative visual analysis and a ROI ratios analysis. On the delayed images, the visual and the ROI ratios analysis showed an improvement of the visualization of the hyper-metabolic specific lesions compared to the SG and the SB. There was also a contrast improvement between the hypo-metabolic specific lesions and the SG with the ROI ratios analysis. Conclusion: delayed acquisitions in FDG-PET improve the visualization of brain tumors from the cortex. Dual phase FDG-PET with delayed acquisition could constitute an additional tool in the management of brain tumors. (authors)

  12. Neurolymphomatosis of the sciatic nerve and F.D.G. PET: case report and review; Neurolymphomatose du nerf sciatique en TEP au FDG: a propos d'un cas et revue de la litterature

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    Bruna-Muraille, C.; Papathanassiou, D.; Cuif-Job, A.; Liehn, J.C. [Institut Jean-Godinot, Service de Medecine Nucleaire, 51 - Reims (France); Job, L. [CHU Robert-Debre, Service de Radiologie, 51 - Reims (France); Kolb, B.; Himberlin, C.; Delmer, A. [CHU Robert-Debre, Service d' Hematologie Clinique, 51 - Reims (France)

    2009-12-15

    We are reporting the case of a woman who has been suffering from sciatica for several months. A neurolymphomatosis of the sciatic nerve was found. In this report, we present the characteristics of this lesion in conventional imaging and in F.D.G. PET. (authors)

  13. Contribution of the PET/CT with {sup 18}F.D.G. in the evaluation of rhabdomyosarcomas in pediatrics; Apport de la TEP/TDM au {sup 18}FDG dans l'evaluation des rhabdomyosarcomes en pediatrie

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    Ricard, F.; Giammarile, F. [Centre hospitalier Lyon-Sud, Pierre-Benite, 69 - Lyon (France); Mognetti, T.; Cimarelli, S. [Centre Leon-Berard, 69 - Lyon (France); Deshayes, E. [Hopital Edouard-Herriot, 69 - Lyon (France)

    2010-07-01

    purpose: evaluate the contribution of PET/CT with {sup 18}F.D.G. in complement of conventional imaging in the initial assessment and the assessment of follow-up of rhabdomyosarcomas in the pediatrics population. Conclusions: the PET/CT with {sup 18}F.D.G. is an efficient technique to evaluate the child rhabdomyosarcomas, in complement of conventional imaging, especially for the bone, osteo-medullary ganglion staging as well as the therapy strategy and the research of the primitive site. We suggest the use of the PET/CT to replace the bone scintigraphy, in complement of local MRI and CT for the initial assessment, the follow-up assessment of pediatrics rhabdomyosarcomas. (N.C.)

  14. Role of F.D.G. ({sup 18}F) PET in para neoplastic neurological syndromes;Place de la TEP au FDG ({sup 18}F) dans l'exploration des syndromes neurologiques paraneoplasiques

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    Daragon, N.; Desarnaud, S.; Kas, A.; Maksud, P.; Abulizi, M.; Habert, M.O. [Groupe hospitalier Pitie-Salpetriere, Service de medecine nucleaire, 75 - Paris (France); Houzard, C. [CHU Lyon-Sud, Service de medecine nucleaire, 69 - Pierre-Benite (France); Pina-Jomir, G. [CHU Lyon Pole-Est, Centre de medecine nucleaire, 69 - Bron (France); Farid, K. [Hotel-Dieu, Service de medecine nucleaire, 75 - Paris (France)

    2010-07-15

    Para neoplastic neurological syndromes (P.N.S.) are rare non-metastatic manifestations of cancer. However, in this family of diseases, to recognize the underlying malignancy is an emergency. The ultimate aim is to treat the patient and try to stabilize or improve the neurological dysfunction, which is frequently the cause of the patient's death. The yield of F.D.G. PET seems to be poor in unselected P.N.S.. In the last decade, neurologists have attempted to provide more rigorous diagnostic criteria for P.N.S.. Thus, 'classical' P.N.S. and a panel of 'well-characterized' onco neural antibodies have been defined in order to facilitate triage of patients for whom F.D.G. PET would be more sensitive. Currently, given the limited availability of PET cameras in France, this examination should be performed in the presence of either a 'classical' P.N.S. with or without onco neural antibodies positivity or other P.N.S. with onco neural antibodies positivity. The F.D.G. PET should be triggered after a negative conventional imaging work up. (authors)

  15. Study of the evolution of aortic atherosclerotic inflammatory plaques using {sup 18}F-FDG PET/CT; Evolution temporelle des foyers inflammatoires d'atherome aortique avec le morphoTEP au {sup 18}F-FDG

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    Bertrand, A.C.; Netter, F.; Muller, M.A.; Djaballah, W.; Bruna, C.; Olivier, P.; Karcher, G.; Marie, P.Y. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 54 - Nancy (France)

    2006-02-15

    PET allows focal uptake of {sup 18}F-FDG to be identified on aortic walls, and these foci might be linked to inflammatory atherosclerotic plaques. The goal of our study was to determine the temporal evolution of these foci. Material and methods: Twenty eight patients undergoing two {sup 18}F-FDG PET/CT within a two month period (1.5{+-}0.5 months on average), were considered. {sup 18}F-FDG uptakes were visually detected on thoracic aorta walls and the maximum activity level of these foci was expressed by a ratio with blood aortic activity (W/B). Results: 35 parietal aortic foci were detected on the initial PET/CT among which 26 were still detected on the second PET/CT together with 5 new foci; therefore the agreement rate between the two examinations was 65% for the visual detection of parietal aortic foci. The ratio W/B was 1.48{+-}0.22 on average. Between the two examinations the evolution of the W/B ratio was only correlated to the initial activity (p=0.02), mainly because the most active foci (W/B>1.6) had a marked activity decrease. Conclusion: When 2 different PET/CT are carried out on the same patients within lower than a two month period, activity from parietal aortic foci seems generally stable, with a concordance rate of 65% between the 2 investigations, and this might relate to a chronic mode of the evolution of inflammation and atherosclerosis. A further decrease in activity was, however, consistently documented for the foci showing the highest activity at baseline, and this might relate to a more evolutive and acute inflammatory process. (author)

  16. Prediction of vascular cerebral accidents by PET T.D.M. with {sup 18}F-F.D.G; Prediction des accidents vasculaires cerebraux par la TEP -TDM vasculaire au 18F-FDG

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    Grandpierre, S.; Chevalier, O.; Thomas, V.; Netter, F.; Meneroux, B.; Karcher, G.; Marie, P.Y. [Service de medecine nucleaire, CHU de Nancy, (France); Desandes, E. [departement d' informatique medical, centre Alexis-Vautrin, Nancy, (France)

    2009-05-15

    This study is the first to show a relationship between the vascular captation of the F.D.G. in PET and the risk of a later ischemic cerebral vascular accident. this relation seems particularly strong for the sources of the carotids junction, so that the PET with F.D.G. could be useful to evaluate the stability of atheromas injuries in this area. (N.C.)

  17. Discovery of Erdheim-Chester disease by PET / CT in 18-F.D.G. with the waning of a prolonged inflammatory syndrome; Decouverte d'une maladie d'Erdheim-Chester par la TEP-TDM au 18-FDG au decours d'un syndrome inflammatoire biologique prolonge

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    Chalaye, J.; Carrier, P.; Viau, P.; Razzouk, M.; Darcourt, J. [CHU-CAL, Service universitaire de medecine nucleaire, 06 - Nice (France)

    2010-07-01

    Purpose: to report a case of Erdheim-Chester disease, a rare non-Langerhans histiocytosis with bone and visceral involvement, of which diagnosis was made using PET-CT with {sup 18}-F.D.G.. PET / CT with {sup 18}F.D.G. revealed and to do the staging of Erdheim-Chester disease, objectifying particularly vascular damage that may condition the prognosis. (N.C.)

  18. {sup 18}F-F.D.G. PET imaging of infection and inflammation: intestinal, prosthesis replacements, fibrosis, sarcoidosis, tuberculosis..; La TEP au {sup 18}F-FDG dans la pathologie inflammatoire et infectieuse: intestinale, prothetique, fibrose, sarcoidose, tuberculose..

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    Fernandez, A.; Cortes, M.; Caresia, A.P.; Juan, R. de; Vidaller, A.; Mana, J.; Martinez-Yelamos, S.; Gamez, C. [Hospital Universitari de Bellvitge, Service TEP-Centre IDI, Services de Medecine Interne, Barcelone (Spain)

    2008-10-15

    Nuclear medicine plays an important role in the evaluation of infection and inflammation. A variety of diagnostic methods are available for imaging this inflammation and infection, most notably computed tomography, {sup 68}Ga scintigraphy or radionuclide labeled leucocytes. Fluorine 18 fluorodeoxyglucose ({sup 18}F-F.D.G.) is a readily available radiotracer that offers rapid, exquisitely sensitive high-resolution images by positron emission tomography (PET). Inflammation can be acute or chronic, the former showing predominantly neutrophilic granulocyte infiltrates, whereas in the latter, macrophages predominate. F.D.G. uptake in infection is based on the fact that mononuclear cells and granulocytes use large quantities of glucose by way of the hexose monophosphate shunts. {sup 18}F-F.D.G. PET accurately helps diagnose spinal osteomyelitis, diabetic foot and in inflammatory conditions such as sarcoidosis and tuberculosis.(it appears to be useful for defining the extent of disease and monitoring response to treatment). {sup 18}F-F.D.G. PET can also help localize the source of fever of undetermined origin, thereby guiding additional testing. {sup 18}F-F.D.G. PET may be of limited usefulness in postoperative patients and in patients with a failed joint prosthesis or bowel inflammatory disease. In this review, we will focus on the role of {sup 18}F-F.D.G. PET in the management of patients with inflammation or suspected or confirmed infection.

  19. Interest of the PET with F.D.G. in the evaluation of patients candidates to hepatic transplantation for hepatocellular carcinoma; Interet de la TEP au FDG dans l'evaluation des malades candidats a la transplantation hepatique pour carcinome hepatocellulaire

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    El Bez, I.; Hamza, F.; Yeddes, I.; Evangelista, E.; Meignan, M.; Itti, E. [CHU Henri-Mondor, Service de medecine nucleaire, 94 - Creteil (France); Decaens, T.; Duvoux, C. [CHU Henri-Mondor, Service d' hepato-gastroenterologie medecine nucleaire, 94 - Creteil (France); Luciani, A. [CHU Henri-Mondor, Service de radiologie, 94 - Creteil (France); Laurent, A. [CHU Henri-Mondor, Service de chirurgie digestive, 94 - Creteil (France)

    2010-07-01

    Purpose: the objective of this study was to evaluate the interest of PET with F.D.G. as predictive factor of progression and output of liver transplant list for hepatocellular carcinoma. Conclusions: These preliminary data show that the positivity of PET with F.D.G. is strongly associated to a output of liver transplant list for tumor progression. (N.C.)

  20. Contribution of the PET/CT with F.D.G. to evaluate the tri therapy and the lymphocyte reconstitution in patients infected by HIV; Apport de la TEP/TDM au FDG pour l'evaluation de la tritherapie et de la reconstitution lymphocytaire chez les patients infectes par le VIH

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    Hamza, F.; Yeddes, I.; El Bez, I.; Evangelista, E.; Meignan, M.; Itti, E. [CHU Henri-Mondor, Service de medecine nucleaire, 94 - Creteil (France); Lelievre, J.D.; Levy, Y. [CHU Henri-Mondor, service immunologie clinique, 94 - Creteil (France); Cheynier, R. [Institut Pasteur, service de virologie, 75 - Paris (France)

    2010-07-01

    Purpose: HIV infection is accompanied by impairment of lymphoid organs that can be detected by PET / CT with F.D.G.. The purpose of this study was to correlate lymphocyte reconstitution with the metabolic activity of lymphoid organs. Conclusions: PET / CT with F.D.G. is an appropriate assessment tool to evaluate the effect of antiviral treatment in lymphoid organs. In addition, she is helping to understand the mechanisms of lymphocyte reconstitution under triple therapy. (N.C.)

  1. Interest of the PET with 18-F.D.G. in the exploration of cardiac tumors. About one case; Interet de la TEP au 18-FDG dans l'exploration des tumeurs cardiaques. A propos d'un cas

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    Lussato, D.; Songy, B.; Penaud, D.; Karila Cohen, D.; Vigoni, F. [Centre cardiologique du Nord, Saint-Denis, (France)

    2009-05-15

    The positron computed tomography (PET) with {sup 18}F.D.G. is today a key examination in oncology, but its use in the exploration of cardiac tumors is not actually established. The PET enlightened a hyper-metabolic injury of the left auricle, reaching to the right pulmonary veins, associated to numerous hyper-metabolic centres: hepatic, osseous and muscular ones. A muscular adjusted biopsy enlightened a metastatic fibrosarcoma. An adapted neoplastic treatment was established. This observation illustrates the potential interest of the PET with {sup 18}F.D.G. in the diagnosis of malignancy of cardiac tumor injuries and their eventual extension evaluation. (N.C.)

  2. Evaluation, characterization and validation in micro-MRI and micro-PET with [{sup 18}F]-F.D.G. of two heterologous murine models of endometrium carcinoma; Mise au point, caracterisation et validation en micro-IRM et micro-TEP au [{sup 18}F]-FDG de 2 modeles murins heterologues de cancer de l'endometre

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    Lefebvre-Lacoeuille, C.; Descamps, P. [Pole gynecologie-obstetrique, CHU d' Angers, (France); Lacoeuille, C.; Couturier, F.O. [service de medecine nucleaire, CHU d' Angers, (France); Scarwell, B.; Bouchet, F. [Inserm U646, universite d' Angers, (France); Lemaire, L.; Hindre, F.; Fusellier, M. [ecole nationale veterinaire de Nantes, (France)

    2009-05-15

    The two murine models of endometrium cancer validated in this work and whom growth can be quantified by {mu}Tep could be used to evaluate the interest of oestrogens labelled with {sup 18}F in the anti tumoral targeted therapies. (N.C.)

  3. FDG PET/CT in initial staging and early response to chemotherapy assessment of paediatric rhabdomyosarcomas; Apport de la TEP/TDM au {sup 18}FDG dans la stadification initiale et l'evaluation precoce de la reponse therapeutique des rhabdomyosarcomes pediatriques

    Energy Technology Data Exchange (ETDEWEB)

    Eugene, T.; Ansquer, C.; Oudoux, A.; Carlier, T.; Kraeber-Bodere, T.; Bodet-Milin, C. [Services de medecine nucleaire, CHU Hotel Dieu, 44 - Nantes (France); Corradini, N.; Thomas, C. [Services d' oncologie pediatrique, CHU Hotel Dieu, 44 - Nantes (France); Dupas, B. [Service de radiologie, CHU Hotel Dieu, 44 - Nantes (France)

    2010-12-15

    Purpose: The objective of this study was to retrospectively evaluate the impact of positron emission tomography/computed tomography (PET/CT) using fluorine-18-fluorodeoxyglucose (FDG), in comparison with conventional imaging modalities (CIM), for initial staging and early therapy assessment in paediatric rhabdomyosarcoma. Patients and methods: Prior to treatment, 18 patients (age range, 9 months to 18 years) with histologically proven rhabdomyosarcoma underwent FDG PET/CT in addition to CIM (magnetic resonance imaging of primary site, whole body CT and bone scintigraphy). After three courses of chemotherapy, 12 patients underwent FDG PET/CT in addition to CIM. RECIST criteria and visual analysis of FDG uptake were used for assessment of response. The standard of reference was determined by an interdisciplinary tumor board based on imaging material, histopathology and follow-up data (median = 5 years). Results: PET/CT sensitivity was superior to CIM's concerning lymph node involvement (100% versus 83%, respectively) and metastases detection (100% versus 50%, respectively). PET/CT results changed therapeutic management in 11% of cases. After three courses of chemotherapy, the rate of complete response was 66% with PET/CT versus 8% with CIM. Five percent of patients relapsed during follow-up (median = 5 years). Conclusion: This study confirms that PET/CT depicts important additional information in initial staging of paediatric rhabdomyosarcomas and suggests a superior prognostic value of PET/CT in early response to chemotherapy assessment. (authors)

  4. Contribution of the PET-CT with {sup 18}F.D.G. in the diagnosis of neurolymphomatosis: about one case; Apport de la TEP-TDM au {sup 18}FDG dans le diagnostic de neurolymphomatose: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Cazaentre, T.; Sanhes, L.; Cassarini, J.F.; Vallentin, X.; Pascal-Ortiz, D. [Hopital Saint-Jean, 66 - Perpignan (France)

    2010-07-01

    The PET with {sup 18}F.D.G. has an important place in the diagnosis, the extension assessment after treatment of the neurolymphomatosis. It is the most sensitive examination and allows to evoke the diagnosis in lack of available histological data. (N.C.)

  5. Metabolic characterisation by PET-T.D.M. with 18 F.D.G. of non secreting adrenal tumors and undetermined by conventional imaging; Caracterisation metabolique par la TEP-TDM au 18 FDG des tumeurs surrenaliennes non secretantes et indeterminees par l'imagerie conventionnelle

    Energy Technology Data Exchange (ETDEWEB)

    Tessonnier, L.; Colavolpe, C.; Mundler, O.; Taieb, D. [Service central de medecine nucleaire, CHU La Timone, Marseille, (France); Sebag, F.; Palazzo, F.F.; Henry, J.F. [service de chirurgie generale et endocrinienne, CHU La Timone, Marseille, (France); De Micco, C. [U 555, Inserm, faculte de medecine de Marseille, (France); Mancini, J. [service de sante publique et information medicale, CHU La Timone, Marseille, (France); Conte-Devolx, B. [service d' endocrinologie, CHU La Timone, Marseille, (France)

    2009-05-15

    The PET-T.D.M. with F.D.G. allows a precise characterization of adrenal tumors with an excellent sensitivity and predictive negative value among these patients. So, a negative examination can be a strong argument for a benign tumor, that could potentially avoid surgery for the adrenal tumors with non conclusive examinations of conventional imaging. (N.C.)

  6. Has F.D.G. PET/CT an impact on the management of patients with anal carcinoma?;La TEP/TDM au FDG a-t-elle un impact dans la prise en charge des patients atteints d'un cancer du canal anal?

    Energy Technology Data Exchange (ETDEWEB)

    Vercellino, L.; Nataf, V.; Kerrou, K.; Huchet, V.; Pascal, O.; Montravers, F.; Talbot, J.N. [Universite Pierre-et-Marie-Curie, Service de medecine nucleaire, hopital Tenon, 75 - Paris (France); De Parades, V.; Bauer, P. [Groupe hospitalier Diaconesses-Croix-Saint-Simon, Service de proctologie medico-interventionnelle, 75 - Paris (France); Touboul, E. [Universite Pierre-et-Marie-Curie, Service d' oncologie-radiotherapie, hopital Tenon, 75 - Paris (France)

    2010-02-15

    Purpose: To evaluate the impact of F.D.G. PET/C Ton the management of patients referred for the staging and/or the follow-up of anal carcinoma, and PET/CT on patient management. Patients and methods: We included patients referred to our department for anal carcinoma whose therapeutic management was evaluable thanks to follow-up data during at least 6 months. Results: Data of 44 patients were analysed: 22 had PET/CT for initial staging and 36 during follow-up. PET/CT had impact in nine patients out of 44 (20%) and it was relevant in eight of them. Conclusion: F.D.G. PET/CT is an accurate imaging modality in anal cancer, its impact on patient management is more obvious when persistence or recurrence of disease is suspected. (authors)

  7. Improvement of early response criteria of the PET with F.D.G. in the aggressive lymphoma: importance of the reference area; Amelioration des criteres de reponse precoce de la TEP au FDG dans le lymphome agressif: importance de la zone de reference

    Energy Technology Data Exchange (ETDEWEB)

    Yeddes, I.; Hamza, F.; El Bez, I.; Lin, C.; Evangelista, E.; Meignan, M.; Itti, E. [CHU Henri-Mondor, Service de medecine nucleaire, 94 - Creteil (France); Dupuis, J.; Haioun, C. [CHU Henri-Mondor, Service d' hematologie, 94 - Creteil (France)

    2010-07-01

    Purpose: PET with F.D.G. allows to identify early the patients that respond or not to the first line chemotherapy, from the second therapy. However, the interpretation criteria currently used (Juweid, international harmonization project. JCO 2007) are adapted to evaluation of end of treatment and non to early evaluation, for which the reference zone allowing to judge the positivity of a residual tumor must be evaluated. Conclusions: To interpret the early response to therapy in aggressive lymphoma, it seems justified to refer to a higher reference level ( liver) than this one advocated in international current criteria (mediastinum). (N.C.)

  8. Place of the PET with {sup 18}F.D.G. in the therapy evaluation of the Hodgkin disease after four chemotherapies; Place de la TEP au 18 FDG dans l'evaluation therapeutique de la maladie de Hodgkin apres 4 cures de chimiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Le Roux, P.Y.; Salauna, P.Y. [CHU de Brest, Service de medecine nucleaire, 29 (France); Milin, C.; Querellou, S.; Kraeber-Bodere, F. [CHU de Nantes, service de medecine nucleaire, 44 (France); Gastine, T.; Le Gouil, S. [CHU de Nantes, service d' hematologie, 44 (France); Rousseau, C. [Centre Rene-Gauducheau, service de medecine nucleaire, 44 - Nantes (France)

    2010-07-01

    Purpose: to evaluate the prognosis value of the PET with F.D.G. in the intermediary therapy evaluation of Hodgkin lymphoma after four chemotherapies, in comparing different criteria of interpretation. Conclusions: our study confirms the excellent negative predictive values of the PET at four chemotherapies in the Hodgkin lymphoma, with different evaluated criteria. The positive predictive value is low with the three methods but PET was decision-making in this series whom 27% of patients were transplanted. The positive predictive value was however higher according to the Gallamini criteria, showing the increased risk of recurrences in this group, even after a graft. (N.C.)

  9. The accurate definition of metabolic volumes on {sup 18}F-FDG-PET before treatment allows the response to chemoradiotherapy to be predicted in the case of oesophagus cancers; La definition precise des volumes metaboliques sur TEP au 18F-FDG avant traitement permet la prediction de la reponse a la chimioradiotherapie dans les cancers de l'oesophage

    Energy Technology Data Exchange (ETDEWEB)

    Hatt, M.; Cheze-Le Rest, C.; Visvikis, D. [Inserm U650, Brest (France); Pradier, O. [Radiotherapie, CHRU Morvan, Brest (France)

    2011-10-15

    This study aims at assessing the possibility of prediction of the response of locally advanced oesophagus cancers, even before the beginning of treatment, by using metabolic volume measurements performed on {sup 18}F-FDG PET images made before the treatment. Medical files of 50 patients have been analyzed. According to the observed responses, and to metabolic volume and Total Lesion Glycosis (TLG) values, it appears that the images allow the extraction of parameters, such as the TLG, which are criteria for the prediction of the therapeutic response. Short communication

  10. About one case of mental anorexia associated with a right frontal partial epilepsy diagnosed in crisis by a PET with {sup 18}F.D.G; A propos d'un cas d'anorexie mentale associee a une epilepsie partielle frontale droite diagnostiquee en crise par une TEP au 18-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Avet, J.; Decousus, M.; Dubois, F. [Service de medecine nucleaire, CHU de Saint-etienne, (France); Galusca, B. [service d' endocrinologie, CHU de Saint-etienne, (France); Convers, P. [service de neurologie, CHU de Saint-etienne, (France); Barral, F.G. [service de radiologie, CHU de Saint-etienne, (France)

    2009-05-15

    The physiology of mental anorexia is very controversial. In some cases, it was described an association with injuries close to the right frontal and temporal lobes. We report the case of an anorexia associated to a partial right frontal epilepsy, fortuitously diagnosed in crisis by a PET with {sup 18}F.D.G.. Conclusions: Because of its closely relationship with the limbic system, the abnormalities touching the right frontal area could contribute to the development of dietary behaviour troubles. This case illustrates this relationship and reports in addition a per-critic PET image of partial epilepsy, that is exceptional because of the tracer kinetics. (N.C.)

  11. Interest of the PET-CT with {sup 18}F.D.G. in the leg type B primitive cutaneous lymphomas. About one case; Interet de la TEP-TDM au 18 FDG dans les lymphomes cutanes primitifs B de type jambe. A propos de deux cas

    Energy Technology Data Exchange (ETDEWEB)

    Thelu-Vanysacker, M.; Razzouk, M.; Darcourt, J. [CHU de Nice, Service de medecine nucleaire, hopital l' Archet, 06 (France); Gutnecht, J. [Hopital Frejus-Saint-Raphael, service d' hematologie, 83 (France); Hubiche, T. [Hopital Frejus-Saint-Raphael, service de dermatologie, 83 (France)

    2010-07-01

    Purpose: to show the interest of PET-CT with {sup 18}F.D.G. in the extension evaluation of 'leg type' B primitive skin lymphomas. They represent 20 to 25 % of skin lymphomas. Three are distinct: lymphomas of marginal area, follicular lymphomas and leg type big cells lymphomas. The two first ones are benign lymphomas and can be treated by excision or radiotherapy for localised forms. Leg type lymphomas are rare, localised on legs and with an unfavourable prognosis potential with frequent recurrences; a clinico histological confrontation and an extension evaluation must allow to propose the best adapted therapy options on avoiding the needlessly aggressive treatments in the forms of good prognosis. Conclusions: These kind of lymphomas must be distinguished from secondary skin localisation of systemic B lymphomas and then the interest of the extension assessment with PET-CT with {sup 18}F.D.G.. The leg type lymphoma has a unfavourable prognosis justifying a treatment by polychemotherapy, of R-C.H.O.P. type (C cyclophosphamide, H hydroxy daunorubicin or doxorubicin, O oncovin or vincristine, P prednisolone, R rituximab). (N.C.)

  12. Interests of the PET-T.D.M. with F.D.G. in the Hodgkin nodular disease lymphocyte predominance type: about one case; Interets de la TEP-TDM au FDG dans la maladie de Hodgkin nodulaire a predominance lymphocytaire: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Puech, J.B.; Guedj, E.; Cammilleri, S.; Mundler, O. [Medecine nucleaire, CHU de La-Timone, Marseille, (France); Curtillet, C.; Michel, G. [hematologie pediatrique, CHU de La-Timone, Marseille, (France)

    2009-05-15

    The objective is to illustrate the interest of the PET-T.D.M. with {sup 18}F.D.G. in the diagnosis of the nodular Hodgkin disease with lymphocyte predominance; or Loppema-Lennert para granuloma. This disease is a rare anatomo-clinical item of Hodgkin disease characterized by a slow evolution, a localised peripheral injury, a trend to local recurrence, and a risk of transformation towards a lymphoma with big cells. This case enlightens the difficulty for the anatomo-pathologist to distinguish follicular lymphoid hyperplasia and nodular Hodgkin with lymphocyte predominance, of different coverage. In spite of the indolent character of this pathology, the PET-T.D.M. with F.D.G. enlightens easily the suspect character of ganglions injuries. This examination takes here a determinant place in the surveillance of these anatomo-clinical entities located at the limit between the benign and the malignant, allowing to guide the behaviour of the hematologist in function of the scintigraphy evolution. (N.C.)

  13. Diagnosis and evaluation of the treatment by PET-T.D.M. with 18 F.D.G. of the digestive origin of an infectious endocarditis complicated with stroke (C.V.A.); Diagnostic et evaluation du traitement, par la TEP-TDM au 18 FDG, de l'origine digestive d'une endocardite infectieuse compliquee d'AVC

    Energy Technology Data Exchange (ETDEWEB)

    Tessonnier, L.; Guedj, E.; Mundler, O. [Service central de medecine nucleaire, CHU de La-Timone, Marseille, (France); Maurel, B. [c service deneuroradiologie, CHU de La-Timone, Marseille, (France); Habib, G. [service de cardiologie, CHU de La-Timone, Marseille, (France); Nicoli, F. [service de neurologie, CHU de La-Timone, Marseille, (France)

    2009-05-15

    (We report the case of a seventeen years old patient sent for an etiological evaluation of an endocarditis, complicated with a cerebral vascular accident, for who the results of conventional imaging examinations were negative. The PET T.D.M. with {sup 18}F.D.G. was realized for the detection of a front door. Effectively, this examination allowed to find a digestive front door in the frame of an infectious endocarditis and direct the complementary adequate explorations. The following of studies will allow to give correctly the contribution of the PET-T.D.M. in infectious and inflammatory pathologies, whether it is in terms of diagnosis, of extension assessment or therapeutic evaluation. (N.C.)

  14. TEP-TDM pour l’exploration du nodule pulmonaire solitaire : acquis et perspectives

    National Research Council Canada - National Science Library

    Groheux, D; Hindié, E; Trédaniel, J; Giraudet, A.-L; Vaylet, F; Berenger, N; Moretti, J.-L

    2009-01-01

    ... (biopsie, chirurgie). La tomographie par émission de positons (TEP) au 18 F-FDG ( 18  Fluorodésoxyglucose) a montré son utilité. Le 18 F-FDG s’accumule dans la plupart des tissus néoplasiques car les cellules cancéreuses présentent le plus souvent une augmentation de la glycolyse avec une surexpression des transporteurs du glucose et de l’activité hex...

  15. Evaluation of the pertinence of PET with {sup 18}F-F.D.G. utilisation in the initial assessments of lymphomas and bronco-pulmonary cancers; Evaluation de la pertinence de l'utilisation de la TEP au {sup 18}F-FDG dans les bilans initiaux des lymphomes et des cancers broncho-pulmonaires

    Energy Technology Data Exchange (ETDEWEB)

    Gries, P.; Caignon, J.M.; Chabane, G.; Peltier, P.; Morineau, N.; Ramee, J.F. [Centre Catherine-de-Sienne, 44 - Nantes (France)

    2010-07-01

    Purpose: to assess the pertinence to use PET with F.D.G. in the initial check up of lymphomas and bronco pulmonary cancers. To analyze their impact on the later therapy decision. Means to implement to correct the possible defaults of prescription. Conclusions: This work revealed the PET is still for numerous practitioners an unrecognized examination, requiring an effort of information. (N.C.)

  16. [Is FDG TEP CT practice changing in the management of sarcomas in adults?].

    Science.gov (United States)

    Kogay, Maria; Thariat, Juliette; Benisvy, Danielle; Dufour, Maxime; Gastaud, Lauris; Saada, Esma; Iannessi, Antoine; Thyss, Antoine

    2016-09-01

    FDG PET (PET)±computed tomography (CT) has increasingly been used in some areas of oncology imaging. It is sometimes performed outside recommendations, at diagnosis or monitoring of sarcomas. We assessed the value of PET-CT in routine practice in sarcomas. All consecutive sarcoma adult patient charts presented at the multidisciplinary sarcoma meeting in a tertiary care center over a period of 10months were examined in order to analyze the performances of PET-CT when available. Of 232 patients, 50 (21 %) underwent a PET-CT. Sensitivity and specificity of PET-CT were 94.7 %, 57.1 %, respectively. SUV values were highly variable, including for a given histology or grade. PET-CT resulted in practice changing in 14 % of cases. When extrapulmonary metastases are suspected and for some subtypes of sarcomas, PET-CT could provide additional information because in view of its good sensitivity. Given the most frequent pulmonary tropism, first hand chest CT may be sufficient at first diagnostic work-up for the detection of pulmonary metastases. However, the relatively poor specificity suggests that further analyses should be performed to identify clinical situations where PET-CT may be of added value compared to current standards. Copyright © 2016 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  17. Evaluation of the gastrointestinal stromal tumors (G.I.S.T.) therapy response by MRI diffusion and apparent diffusion coefficient (ADC): comparison to the PET-CT with {sup 18}F-F.D.G; Evaluation de la reponse therapeutique des GIST par IRM de diffusion et CDA: comparaison a la TEP-TDM au {sup 18}F-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Dunet, V.; Prior, J. [CHU Vaudois, Departement de medecine nucleaire, Lausanne (Switzerland); Koehli, M.; Meuli, R.; Schmidt, S. [CHU Vaudois, Departement de radiologie, Lausanne (Switzerland); Montemurro, M.; Leyvraz, S. [CHU Vaudois, Departement d' oncologie, Lausanne (Switzerland)

    2010-07-01

    Purpose: Determine the clinical potential of diffusion MRI with mapping of apparent diffusion coefficient for evaluating the therapeutic response of gastrointestinal stromal tumors (G.I.S.T.) in comparison to PET-CT with {sup 18}F-F.D.G.. Conclusions: The variations of apparent diffusion coefficient seems to reflect the therapeutic response of G.I.S.T. lesions avid for {sup 18}F-F.D.G.. Nevertheless, its interest seems limited in the case of small lesions and remains to be determined for the assessment of G.I.S.T. lesions that do not hold {sup 18}F- F.D.G.. (N.C.)

  18. Evaluation at half treatment of the response to chemotherapy by PET with {sup 18}F-F.D.G. in the locally evolved cancers of esophagus; Evaluation a mi-traitement de la reponse a la chimioradiotherapie par TEP au 18F-FDG dans les cancers de l'oesophage localement evolues

    Energy Technology Data Exchange (ETDEWEB)

    Moretti, J.L.; Hindie, E.; Teyton, P. [Service de medecine nucleaire, hopital Saint-Louis, Paris, (France); Maylin, C.; Quero, L.; Cuenca, X.; Hennequin, C. [service de cancerologie et radiotherapie, hopital Saint-Louis, Paris, (France)

    2009-05-15

    The evaluation of the response to chemo-radiotherapy in the esophagus cancers could give directions for the therapy decision towards surgery or continuation of chemo-radiotherapy. The conclusions are that the {sup 18}F.D.G. PET-T.D.M. can help the early evaluation of the response to chemo-radiotherapy in the locally evolved esophagus cancers but cannot take the place single-handedly to the endoscopic and radiological evaluation. The three examinations are complementary to the decision of an eventual surgery after chemo-radiotherapy. (N.C.)

  19. Interest of delayed acquisition in PET {sup 18}F-F.D.G. in the management of patients suffering of alveolar echinococcosis;Interet de l'acquisition tardive en TEP au 18-FDG dans la prise en charge des patients atteints de l'echinococcose alveolaire

    Energy Technology Data Exchange (ETDEWEB)

    Blagosklonov, O.; Richou, C.; Bresson-Hadni, S.; Vuitton, D.A. [CHU de Besancon, CC OMS pour l' echinococcose humaine, 25 - Besancon (France); Caoduro, C.; Ungureanu, C.M.; Quemard, G.; Boulahdour, H. [CHU de Besancon, 25 - Besancon (France)

    2010-05-15

    The alveolar echinococcosis is a disease caused by development in the liver of the larva of tapeworm (E. multilocularis). Until now, a lifelong treatment was recommended for unresectable patients (60 to 70%). The PET with {sup 18}F.D.G. offers the possibility of a morpho-functional assessment of the disease. A negative result in PET could allow to reinforce the hypothesis of a possible involution and to proceed to stop treatment. To prevent recurrent disease without treatment, it is necessary to minimize the risk of a false-negative PET. The objective of this study is to evaluate the interest of a delayed acquisition ( three hours after injection) to increase the sensitivity of the PET with F.D.G.. As conclusion: Stopping the treatment is an important decision, it was demonstrated that the parasite can remain viable, in spite of the negative PET. The study confirmed that the realisation of a delayed acquisition is useful because it allowed to improve the sensitivity of the PET in 29% of cases. (N.C.)

  20. The role of the F.D.G.-PET in the evaluation of efficacy of radiofrequency treatment of metastases; Role de la TEP au FDG dans l'evaluation de l'efficacite du traitement des metastases par radiofrequence. Premiers resultats

    Energy Technology Data Exchange (ETDEWEB)

    Ungureanu, C.M.; Angoue, O.; Blagosklonov, O.; Zsigmond, R.; Boulahdour, H. [CHU Jean-Minjoz, Service de Medecine Nucleaire, 25 - Besancon (France); Kastler, B. [CHU Jean-Minjoz, Service de Radiologie, 25 - Besancon (France)

    2009-09-15

    Objectives Methods such as MRI and CT usually utilized in the assessment of the radiofrequency (RF) efficacy proved to be insufficient in the early detection of the residual tumors after RF treatment. In this study, we evaluated the effectiveness of utilizing the PET-CT in the follow-up of the RF treated patients. Methods PET-CT was performed before and after five RF treatments (three patients). Absence of focally increased F.D.G. uptake was considered complete efficacy, while the presence of focally increased F.D.G. uptake was considered incomplete efficacy. The efficacy was estimated on the PET-CT performed in the same day to three months after the RF treatment. Every RF administration was followed by at least two PET-CT exams. We used radiological evaluation as a control method. Results Complete efficacy was found for three of the five RF treatments and incomplete efficacy in two cases. The disease evolution confirmed the results obtained through PET-CT in 100% of the cases studied. Conclusion This preliminary study showed that the PET-CT has the potential of evaluating the efficacy of the RF treatment. Our findings showed that the PET-CT may very early evidence the presence of residual tumors. (authors)

  1. Role of {sup 18}F-F.D.G. PET/CT in management of patients with differentiated thyroid cancer;Impact de la TEP/TDM au {sup 18}F-FDG dans la prise en charge des patients atteints de cancer thyroidien differencie

    Energy Technology Data Exchange (ETDEWEB)

    Sibille, L.; Guillemard, S.; Eberle-Pouzeratte, M.C.; Espitalier-Riviere, C.; Faurous, P.; Artus, J.C. [CRLC Val-d' Aurelle-P.-Lamarque, Service de medecine nucleaire, 34 - Montpellier (France); Thezenas, S. [CRLC Val-d' Aurelle-P.-Lamarque, Unite de biostatistiques, 34 - Montpellier (France); Lamy, P.J. [CRLC Val-d' Aurelle-P.-Lamarque, Centre d' immuno-radio-analyse, 34 - Montpellier (France); Rossi, M. [CHU de Montpellier, Service de medecine nucleaire, 34 - Montpellier (France)

    2010-02-15

    {sup 18}F-F.D.G. PET/CT by combining both metabolic and anatomical information has proven to be an effective modality for detecting many types of cancer. Some differentiated forms of cancer like differentiated thyroid carcinoma (D.T.C.) are less F.D.G. avid and thus less easily detectable. Nevertheless {sup 18}F-F.D.G. PET/CT has been proved useful in D.T.C. especially in case of suspected recurrent disease with negative whole-body radioiodine scintigraphy ({sup 131}I W.B.S.) and elevated thyroglobulin (Tg) or thyroglobulin autoantibodies (AbTg) levels. Impact on clinical management after {sup 18}F-F.D.G. PET/CT examinations has been analyzed in patients with suspected recurrent D.T.C. in this retrospective study. Methodology. Fifty-five {sup 18}F-F.D.G. PET/CT were performed in 45 patients with suspected recurrent or residual disease either because of elevated Tg/AbTg levels (n 45) or uncertain conventional imaging (n = 10) including {sup 131}I W.B.S., cervical echography and CT scan if necessary. {sup 18}F-F.D.G. PET/CT results were compared with histopathology and/or clinical follow-up with evaluation of impact on clinical management. Results. Twenty-nine exams were positive (53 %). There were 20 true-positive (T.P.) (14 locoregional relapses and six with distant metastases) and nine false-positive (F.P.) (all cervical). SUV{sub max} median values of hyper-metabolic foci were significantly higher in T.P. (5.1) than in F.P. (2.8). Overall, 20 (36 %) {sup 18}F-F.D.G. PET/CT directly affected clinical management resulting in 13 (65 %) new surgical operations. Sensitivity, specificity, predictive positive value, predictive negative value and accuracy of {sup 18}F-F.D.G. PET/CT were estimated for the whole group (respectively 83 %, 71 %, 69 %, 85 % and 76 %) and for two subgroups depending on Tg level (less or more than 1.2 ng/ml). Discussion and conclusion. {sup 18}F-F.D.G. PET/CT is a powerful and useful tool in patients with suspected D.T.C. recurrence or residual

  2. Evaluation of a PET-T.D.M. with {sup 18}F-F.D.G. in mode List 1 acquisition protocol and a dynamic phantom of head and neck cancer simulation; Evaluation d'un protocole d'acquisition TEP-TDM au 18- FDG en mode List1 et d'un fantome dynamique de simulation de cancer de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Dierickx, L.; Nalis, J.; Zerdoud, S.; Robert, A.; Caselles, O.; Courbon, F. [Institut Claudius-Regaud, Toulouse, (France)

    2009-05-15

    A pharmacokinetic analysis of F.D.G. can improve the diagnosis accuracy of the PET-T.D.M; for the simulation in radiotherapy and the post operative evaluation of head and neck cancer. A protocol of dynamic acquisition in list mod allows to test and optimize the different parameters of acquisition for a clinical application. the aim of this study is to develop a dynamic phantom of head and neck cancers simulation and to evaluate the influence of acquisition and reconstruction parameters ( temporal sampling,: bin, correction of random events) on the quantitative analysis. Conclusions: we dispose of a model adapted to the quality control and optimization of pharmaco-dynamic studies in PET-T.D.M; with {sup 18}F.D.G. of head and neck cancers. (N.C.)

  3. 2-[{sup 18}F]fluoro-2-deoxy-D-glucose positron emission tomography (F.D.G.-PET) can identify chronic lymphocytic leukaemia (C.L.L.) stage A et stage B patients; La tomographie par emission de positons au 2-[{sup 18}F] fluoro-2-desoxy-D-glucose (TEP-FDG) permet d'identifier les stades A et B des leucemies lymphoides chroniques (LLC)

    Energy Technology Data Exchange (ETDEWEB)

    Berthelot, C.; Vervueren, L.; Le Jeune, J.J.; Couturier, O. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 49 - Angers (France); Truchan-Graczyk, M.; Genevieve, F.; Ifrah, N. [Centre Hospitalier Universitaire, Service d' Hematologie, 49 - Angers (France); Poirier, A.L. [BEC, centre Paul-Papin, 49 -Angers (France); Artur-Guillemette, P. [Centre Hospitalier Universitaire, Service de Radiologie, 49 - Angers (France)

    2009-09-15

    Purpose: There is no data in the literature concerning the utility of 2-[{sup 18}F]fluoro-2-deoxy-d-glucose positron emission tomography (F.D.G.-PET) in chronic lymphocytic leukaemia (C.L.L.), except for the diagnosis of Richter's transformations. The purpose of this study was to assess the potential role of F.D.G.-PET in C.L.L. stages A and B. Materials and methods Thirty-five patients (61 {+-} 9 years; 11 women, 24 men; 8 B and 27 A) have benefited of a F.D.G.-PET scan at baseline, for example, before an eventual treatment. F.D.G.-PET scans were analyzed visually and the maximum values of the Standardised Uptake Value (S.U.V.{sub max}) were measured in the main lymph nodes areas. The ability of F.D.G.-PET to differentiate stages A and B patients was evaluated by Student's tests and Receiver Operating Characteristics (R.O.C.) analysis. Results All patients with a normal F.D.G.-PET (n = 18) were stages A. The remaining 17 patients (9 A and 8 B) showed hyper metabolisms in nodal areas above (n = 17) and below (n = 9) the diaphragm, and no visceral involvement. The lymph nodes hyper metabolisms were always bilateral, and of low intensity (= mediastinum; 9 A), or of higher intensity (= liver, 8 B). The S.U.V.{sub max} of stage B (n = 8) were significantly higher than those of the 27 stages A, in all lymph nodes areas except in mediastinum. The highest intensity of F.D.G. uptake was observed in axillary area in stages B patients (S.U.V.max = 2.74 {+-} 1.03). An axillary S.U.V.{sub max} of 1.33 is the most suitable value for the discrimination between stages A and B patients (R.O.C.; AUC = 0.968; sensitivity 1.00; specificity 0.91). Conclusion Lymph nodes hyper metabolisms are constant in the B stage, and more intense than in stage A. These anomalies are always bilateral, unlike what is observed in Richter's transformation. The intensity of axillary lymph nodes F.D.G. uptake can distinguish C.L.L. stages A and B. (authors)

  4. Role of FDG-PET for the diagnosis of differentiated thyroid cancer relapse examination of 39 patients; Utilisation de la TEP-18FDG pour le diagnostic des recidives des cancers thyroidiens differencies. Analyse de 39 observations

    Energy Technology Data Exchange (ETDEWEB)

    Groheux, D.; Garin, E.; Bernard, A.M.; Devillers, A.; Lescouarc' h, J.; Prigent-Le Jeune, F.; Carsin, A.; Bourguet, P.; Herry, J.Y. [Centre Regional de Lutte contre le Cancer Eugene Marquis, Dept. d' Imagerie Medicale, 35 - Rennes (France); Mesbah, H. [Centre Regional de Lutte contre le Cancer Eugene Marquis, Dept. d' Information Medicale, 35 - Rennes (France)

    2005-03-01

    Thirty nine patients with differentiated thyroid carcinoma (32 papillary, 4 follicular and 3 oncocytic) were studied by 18FDG whole-body PET in most cases because of elevated thyroglobulin. All patients were examined with hormone substitution at low TSH levels. Fourteen patients had 18FD G uptake in cervical region, 9 in mediastinum and 5 in lungs. Sensitivity of FDG-PET was 68%, specificity 71%, PPV 8% and NPV 56%. Sensitivity was respectively 53% and 90% if thyroglobulin was inferior or superior to 10 ng/ml. FDG-PET changed cancer staging in 27 patients and changed treatment strategy in 11 patients (10 surgical treatments and 1 radioiodine therapy). (author)

  5. F.D.G. PET role in the localisation of primary neoplasias; Place de la TEP au {sup 18}FDG dans la localisation de primitifs neoplasiques

    Energy Technology Data Exchange (ETDEWEB)

    Audigier, C.; Billotey, C.; Deshayes, E.; Banayan, S.; Janier, M. [Lyon Univ., CREATIS (CNRS UMR 5220, Inserm U630), Service de Medecine Nucleaire, Hopital Edouard-Herriot, Faculte de Medecine Lyon-Nord, Hospices Civils de Lyon, 69 - Lyon (France)

    2009-08-15

    Carcinomas of unknown primary site (C.U.P.) and para neoplastic syndromes have the common characteristic that an extensive conventional biological and imaging analysis fails in some instance to detect the primary tumour. F.D.G.-PET becomes recognized to provide interesting information in the case of 'head and neck' C.U.P. as well as in the case of neurological para neoplastic syndromes biologically well defined. When, either C.U.P. or para neoplastic syndromes, are less defined, F.D.G.-PET will not provide as much information as in the previous situation, although it can help in the etiologic diagnosis (oncologic or not) in some cases. (authors)

  6. PET/CT detection of incidental colorectal foci of F.D.G. uptake: Correlation with colonoscopy results;Decouverte fortuite de fixations colorectales focales du FDG en TEP/TDM: correlation aux donnees de la coloscopie

    Energy Technology Data Exchange (ETDEWEB)

    Nouira, M.; Evangelista, E.; Meignan, M.; Itti, E. [Universite Paris-12, Service de medecine nucleaire, hopital Henri-Mondor, AP-HP, 94 - Creteil (France); Sobhani, I. [Universite Paris-12, Service de gastroenterologie, hopital Henri-Mondor, AP-HP, 94 - Creteil (France); Hagege, H. [centre hospitalier intercommunal, Service de gastroenterologie, 94 - Creteil (France); Meignan, M.; Itti, E. [EAC CNRS 7054, 94 - Creteil (France)

    2010-04-15

    Purpose: F.D.G.-PET is an established tool for the diagnosis of recurrent or metastatic colorectal carcinoma. Several case series suggest that F.D.G.-PET often detects incidental adenomatous polyps or colorectal adenocarcinomas. The aim of this study was to correlate unexpected colorectal foci of F.D.G. uptake to pathology findings after systematic colonoscopy. Patients and methods: We reviewed the records of 3541 patients who underwent F.D.G. PET/CT in our institution over a 30-month period for the assessment of a known or suspected malignancy. In 85 of them, incidental, nodular shaped and well-circumscribed foci of abnormal uptake were identified in the area of the colon or rectum. Patients with segmental or diffuse abnormal colorectal uptake were excluded, as well as patients with known benign or malignant colorectal disease. Colonoscopy and complete pathology report was available in 29 patients. Maximal standardized uptake value (SUV{sub max}) was measured in all lesions. Results: Unexpected colorectal foci of F.D.G. uptake were associated with colonoscopic abnormalities in 23 patients (true positive rate: 79 %). Adenocarcinomas were found in six patients (SUV{sub max} = 7.3 +- 2.6), tubular adenomas in four patients (SUV{sub max} = 7.3 +- 4.9) and tubulovillous adenomas in 12 patients (SUV{sub max} = 4.2 +- 1.1). Hyperplasic polyps with no sign of dysplasia were found in the last patient (SUV{sub max} 3.3). Concomitant CT abnormalities were found on PET/CT fusion in eight patients and consisted of wall thickening (n = 5) or nodular mass (n = 3). Conversely, PET was falsely positive in six patients (21 %), with no concomitant CT abnormalities and no abnormal findings at endoscopy (SUV{sub max} 6.2 +- 2.8, no significant difference with true positive lesions). Conclusion: Our findings emphasize the need to perform a colonoscopy in front of incidental nodular colorectal foci of F.D.G. uptake because malignant or pre-malignant neoplasms, which are not clinically

  7. From light to dark grey: Aspects of peritoneal carcinomatosis on PET/CT;Du gris clair au gris fonce Exploration de la carcinose peritoneale par TEP-TDM

    Energy Technology Data Exchange (ETDEWEB)

    Poullias, X.; Gontier, E.; Dechaud, C.; Foehrenbach, H.; Bonardel, G. [Hopital du Val-de-Grace, Service de medecine nucleaire, 75 - Paris (France)

    2010-07-15

    F.D.G. or F dopa PET/CT is a powerful imaging technique for detection and characterization of peritoneal carcinomatosis. Diagnosis features and main differential diagnoses are presented from clinical reports. (authors)

  8. F.D.G.-PET scanning in managing patients with lymphoma; La place de la TEP au FDG dans l'evaluation des lymphomes

    Energy Technology Data Exchange (ETDEWEB)

    Bodet-Milin, C.; Kraeber-Bodere, F. [CHU de Nantes, Service de Medecine Nucleaire, Hotel-Dieu, 44 - Nantes (France); Salaun, P.Y. [CHU de Brest, Service de Medecine Nucleaire, 29 - Brest (France); Crespin, C.; Vuillez, J.P. [CHU de Grenoble, Service de Medecine Nucleaire, 38 - Grenoble (France); Kraeber-Bodere, F. [Centre Rene-Gauducheau, Service de Medecine Nucleaire, 44 - Saint-Herblain (France); CRCNA, Inserm UMR 892, 44 - Nantes (France)

    2009-08-15

    The place of positron emission tomography (PET) in the evaluation of diffuse at big cells B lymphomas and hodgkin lymphomas is validated. The clinical impact of the PET registered in end of therapy development is indisputable. recommendations must be followed for images interpretation. The PET is strongly recommended during the first evaluation of the disease because it is a reference examination that makes easy the interpretation at the end of the therapy and allows to evaluate the extension of the disease with a sensitivity and a specificity superior to the computerized tomography. the prognosis value of intermediate evaluations appears certain in the diffuse at big cells B lymphomas and the hodgkin lymphomas but the impact of an early therapy change induced by PET is still to determine. The criteria of interpretation of early evaluations are to standardize. for the other types of lymphomas, the PET can have an interest to confirm the the localized stages, especially for the follicular lymphomas and direct the biopsy for a patient ill of a low range lymphoma suspect of aggressive change. (N.C.)

  9. Clinical signification of diffuse thyroid uptake on {sup 18}F-FDG PET-CT; Signification clinique des hyperfixations thyroidiennes diffuses du 18F-fluorodeoxyglucose en Morpho-TEP: a propos de 28 cas

    Energy Technology Data Exchange (ETDEWEB)

    Bruna, C.; Journo, A.; Netter, F.; Muller, M.A.; Olivier, P.; Karcher, G. [Centre Hospitalier Universitaire Nancy-Brabois, Service de Medecine Nucleaire, 54 - Vandoeuvre-les-Nancy (France)

    2007-03-15

    Aim and methods: This retrospective study, performed on 28 patients. gave us the opportunity to evaluate the interest of the description of diffuse thyroid uptake on {sup 18}F-FDG PET/CT. Indeed. this topic is rarely treated in the literature. The first aim of our study was to search for the previous history of thyroid disease of the patients for whom a diffuse uptake was reported. We also evaluated the ability of the procedure to help the diagnosis of unknown thyroid pathologies. Results: Eighteen patients out of 28 had previous history of thyroid disease: most of them were already treated. For the other 10 patients. the FDG PET/CT allowed the detection of two chronic thyroiditis without biological abnormalities. one hypothyroidism and one hyperthyroidism. Five patients had normal thyroid biology and for an additional one, the diffuse uptake was probably in relation with a known lymphoma. Conclusion: This study confirms that the majority of patients with diffuse thyroid uptake of {sup 18}F-FDG are related to previously known chronic thyroiditis, Basedow disease or goiter. Only one case was in relation with a neoplastic pathology (lymphoma). When patients have no previous thyroid disease, biology should be performed to detect a hypo- or hyperthyroidism, which could require a treatment. These results should be confirmed in a prospective way. (authors)

  10. Place of the PET with F.D.G. in the taking charge of cortico-adrenal tumors; Place de la TEP au FDG dans la prise en charge des tumeurs corticosurrenaliennes

    Energy Technology Data Exchange (ETDEWEB)

    Thelu-Vanysacker, M.; Hossein-Foucher, C.L.; Marchandise, X. [Service central de medecine nucleaire, CHU de Lille, (France); Carnaille, B. [chirurgie endocrinienne, CHU de Lille, (France); Do Cao, C. [clinique M.-Linquette, CHU de Lille, (France); Aubert, S. [laboratoire d' anatomopathologie, CHU de Lille, (France)

    2009-05-15

    In preoperative the PET-F.D.G. is recommended in the management of suspect cortico-adrenal tumors. It cannot be recommended systematically in the evaluation of any cortico-adrenal tumor. The SUV{sub max} of the tumor can be got as preoperative argument of malignancy and it seems to be a prognosis value. More, the preoperative PET-F.D.G. appears necessary to the initial extension evaluation. its contribution in postoperative seems to be in second intention. (N.C.)

  11. Interest of the PET/T.D.M. with 18 F.D.G. in the cholangio-carcinoma; Interet de la TEP/TDM au 18F-FDG dans le cholangiocarcinome

    Energy Technology Data Exchange (ETDEWEB)

    Morvan, J.; El Esper, I.; Moullart, V.; Saidi, L.; Meyer, M.E. [Service de medecine nucleaire, CHU Amiens Sud, (France); Demuynck, F.; Yzet, T. [service de radiologie digestive, CHU Amiens Nord, (France); Fuks, D.; Regimbeau, J.M. [service de chirurgie viscerale, CHU Amiens Nord, (France); Chatelain, D. [service d' anatomopathologie, CHU Amiens Nord, (France)

    2009-05-15

    The specificity of the PET/T.D.M. for the evaluation of the ganglion attack is superior to the scanner one. The PET/T.D.M. is more noticeable than the scanner in the detection of metastases. It appears as complementary to other modalities of imaging in the staging of cholangio-carcinoma and seems indicated among patients judged operable by conventional imaging. (N.C.)

  12. Interests of the PET with 18-F.D.G. in infectious pathology: about a case of systemic candidiasis; Interets de la TEP au 18-FDG en pathologie infectieuse: a propos d'un cas de candidose systemique

    Energy Technology Data Exchange (ETDEWEB)

    Avet, J.; Granjon, D.; Prevot, N.; Isnardi, V.; Dubois, F. [Service de medecine nucleaire, CHU de Saint-etienne, (France); Stephan, J.L.; Berger, C. [service de pediatrie, CHU de Saint-etienne, (France)

    2009-05-15

    We report the interest of the PET with {sup 18}F-F.D.G. in the extension evaluation of injuries and in the therapy decision for a patient suffering of a systemic candida. Conclusions: In spite of a lack of recommendations, because of its great sensitivity for the deep infectious centres detection, the PET with {sup 18}F-F.D.G. can bring useful information to the management and follow up of the systemic infections. (N.C.)

  13. Total extraperitoneal endoscopic hernioplasty (TEP).

    Science.gov (United States)

    Kuthe, A; Mainik, F; Flade-Kuthe, R

    2014-04-01

    One can no longer think about modern hernia surgery without mentioning endoscopic techniques. But due to their high technical demands the learning curve is comparatively long. And by technical mistakes and their consequences (pain, recurrence, complications) the benefits of the endoscopic techniques can easily be turned to drawbacks. The following text explains the steps of the total extraperitoneal endoscopic hernioplasty (TEP) technique in detail pointing out alternatives and risks. From preparation, indication and positioning, from trocar placement to extraperitoneal dissection and mesh placement, the principles of TEP are elucidated in respect of local anatomy and possible complications. The text as well as the accompanying video in the Mediathek are based on the authors' 20 years of experience in the TEP technique. Both of them may help in safe TEP application to minimise the complication rate as well as recurrences. Then patients can benefit from the advantages of this technique. Georg Thieme Verlag KG Stuttgart · New York.

  14. [Evidence-based TEP technique].

    Science.gov (United States)

    Köckerling, F

    2017-04-01

    The guidelines of all international hernia societies recommend as procedures of choice the laparoendoscopic techniques total extraperitoneal patch plasty (TEP) and transabdominal preperitoneal patch plasty (TAPP) as well as the open Lichtenstein operation for elective inguinal hernia repair. The learning curve associated with the laparoendoscopic techniques, in particular TEP, is longer than that for the open Lichtenstein technique due to the complexity of the procedures. Accordingly, for laparoendoscopic techniques it is particularly important that the operations are conducted in a standardized manner in compliance with the evidence-based recommendations given for the technical details. When procedures are carried out in strict compliance with the guidelines of the international hernia societies, low rates of perioperative complications, complication-related reoperations, recurrences and chronic pain can be expected for TEP. Compliance with the guidelines can also positively impact mastery of the learning curve for TEP. The technical guidelines on TEP are based on study results and on the experiences of numerous experts; therefore, it is imperative that they are implemented in routine surgical practice.

  15. Marine bacterial transparent exopolymer particles (TEP) and TEP precursors: Characterization and RO fouling potential

    KAUST Repository

    Li, Sheng

    2015-10-31

    This paper investigated the characteristics and membrane fouling potential of bacterial transparent exopolymer particles (TEP)/TEP precursors released from two marine bacteria, Pseudidiomarina homiensis (P. homiensis) and Pseudoalteromonas atlantica (P. atlantica), isolated from the Red Sea. Results showed that both bacteria grew at the similar rate, but the production of TEP/TEP precursors from P. atlantica was higher than that from P. homiensis. During the 168. h of incubation time, production rates of TEP/TEP precursors from P. atlantica and P. homiensis were 0.30 and 0.08 xanthan gum eq. mg/L-h, respectively. Isolated bacterial TEP precursors were mainly biopolymer, and P. atlantica produced a significantly higher concentration of biopolymer than that produced by P. homiensis. TEP/TEP precursors from both marine bacteria possessed protein-like material and were very similar in composition to previously reported foulants isolated from a fouled reverse osmosis (RO) membrane. Bacterial TEP/TEP precursors mostly consisted of aliphatic hydrocarbon from amino acids and amide group carbon of proteins (around 55%). Bacterial TEP precursors caused obvious fouling on RO membranes, which may create an ideal environment for bacteria attachment and promote to biofouling.

  16. Occurrence of transparent exopolymer particles (TEP) in drinking water systems

    OpenAIRE

    Van Nevel, Sam; Hennebel, Tom; Verstraete, Willy; Boon, Nico

    2011-01-01

    Numerous membrane fouling studies have been conducted to predict and prevent membrane fouling. It was only recently that a new parameter, TEP, was introduced in this research. The deposition of TEP on reverse osmosis (RO) membranes has already been imaged, correlations between ultrafiltration (UF) fouling and TEP concentrations have been reported. Furthermore, TEP deposition takes place in an early stage of aquatic biofilm formation, making TEP one of the accused in search for biofilm initiat...

  17. Contribution of the PET-T.D.M. with {sup 18}F-F.D.G. in the pharyngo-larynx sarcoidosis; Apport de la TEP-TDM au 18F-FDG dans les sarcoidoses pharyngo-laryngees

    Energy Technology Data Exchange (ETDEWEB)

    Ben Sellema, D.; Imperiale, A.; Constantinesco, A. [Service de medecine nucleaire, hopital Hautepierre, Strasbourg, (France); Braun, J.J. [service ORL, hopital Hautepierre, Strasbourg, (France)

    2009-05-15

    The objective was to evaluate the interest of the PET-T.D.M. with {sup 18}F-F.D.G in the diagnosis of larynx and pharynx sarcoidosis. The {sup 18}F-F.D.G./PET-T.D.M. is a noticeable and useful method for the diagnosis and the inflammatory mapping of the sarcoidosis, especially the atypical pharynx and larynx forms and seems more contributive than the scintigraphy with {sup 67}Ga. (N.C.)

  18. {sup 18}F-F.D.G. PET for staging and monitoring of solitary plasmocytomas;La TEP au {sup 18}F-FDG dans le diagnostic et le suivi evolutif des plasmocytomes solitaires

    Energy Technology Data Exchange (ETDEWEB)

    Adib, S.; Robua, D.; Huglo, D.; Steinling, M. [CHU de Lille, rue Michel-Polonovski, Service de medecine nucleaire, hopital Claude-Huriez, 59 - Lille (France); Robua, D.; Leleu, X. [CHU de Lille, rue Michel-Polonovski, Service des maladies du sang, hopital Claude-Huriez, 59 - Lille (France)

    2010-02-15

    Aim: To assess the role of [{sup 18}F]F.D.G.-PET in solitary plasmocytomas with regards to staging, therapeutic follow-up and monitoring. Patients and methods. Twenty consecutive patients were included in the present study when following conditions were met: (1) solitary plasmocytomas histologically confirmed (bone, n = 16; extramedullary, n = 4); (2) [{sup 18}F]F.D.G.-PET scan from July 2004 to April 2009. The clinical follow-up was over than 2 years for 13 patients. Ten patients underwent a post-therapy PET scan. PET scans were visually analysed. Results. PET scan enabled confirmation of all main lesions (sensitivity: 100%) and also detected infra-clinical lesions in eight cases. Follow-up for more than 2 years showed a progression disease into myeloma in five from six cases (83%) with infra clinical lesions at the baseline PET scan. Among 10 patients who underwent post-therapeutic PET scan, six experienced a complete response at the main lesion site and four experienced a partial response. Conclusion: F.D.G.-PET may play an important role in plasmocytomas staging and enables detection of smaller lesions (otherwise undetected). (authors)

  19. {sup 18}F-F.D.G. PET image segmentation. Principles and literature reviewing;Segmentation des images TEP au 18F-FDG. Principe et revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Vauclin, S.; Gardin, I.; Doyeux, K.; Hapdey, S.; Edet-Sanson, A.; Vera, P. [Universite de Rouen, Laboratoire LITIS - EA 4108, 76 - Saint-Etienne-du-Rouvray (France); Vauclin, S.; Doyeux, K. [Siemens Medical Solutions, 93 - Saint-Denis (France); Gardin, I.; Hapdey, S.; Edet-Sanson, A.; Vera, P. [Centre Henri-Becquerel, centre hospitalier universitaire de Rouen, Departement de medecine nucleaire, 76 - Rouen (France)

    2010-06-15

    Several segmentation methods of lesion uptake in {sup 18}F-F.D.G. PET imaging have been proposed in the literature. Their principles are presented along with their clinical results. The main approach proposed in the literature is the thresholding method. The most commonly used is a constant threshold around 40% of the maximum uptake within the lesion. This simple approach is not valid for small (< 4 or 5 ml), poorly contrasted positive tissue (SUV < 2) or lesion in movement. To limit these problems, more complex thresholding algorithms have been proposed to define the optimal threshold value to be applied to segment the lesion. The principle is to adapt the threshold following a fitting model according to one or two characteristic image parameters. Those algorithms based on iterative approaches to find the optimal threshold value are preferred as they take into account patient data. The main drawback is the need of a calibration step depending on the PET device, the acquisition conditions and the algorithm used for image reconstruction. To avoid this problem, some more sophisticated segmentation methods have been proposed in the literature: derivative methods, watershed and pattern recognition algorithms. The delineation of positive tissue on F.D.G.-PET images is a complex problem, always under investigation. (authors)

  20. PET with {sup 18}F-F.D.G. in the diagnosis and the evolutionary follow up of solitary plasmocytomas; La TEP au {sup 18}F-FDG dans le diagnostic et le suivi evolutif des plasmocytomes solitaires

    Energy Technology Data Exchange (ETDEWEB)

    Adib, S.; Huglo, D.; Steinling, M. [Hopital Huriez, CHU de Lille, Service de medecine nucleaire, 59 (France); Leleu, X.; Robu, D. [Hopital Huriez, CHU de Lille, service des maladies du sang, 59 (France)

    2010-07-01

    Purpose: evaluate the contribution of PET with {sup 18}F-F.D.G. in the diagnostic assessment, post therapy evaluation and evolutionary follow-up of solitary plasmocytomas. Conclusions: the PET with {sup 18}F-F.D.G. seems to be an efficient diagnostic tool in the staging of solitary plasmocytomas and allows also to detect infra clinical injuries unknown by other imaging techniques. (N.C.)

  1. Influence of breathing movement on the quantitative measurement in PET/CT with {sup 18}F-F.D.G; Influence du mouvement respiratoire sur la mesure quantitative en TEP/TDM au {sup 18}F-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Vercellino, L.; Martineau, A.; Berenger, N.; Hindie, E.; Peretti, I.; Moretti, J.L. [CHU Saint-Louis-Lariboisiere, 75 - Paris (France); Sfar, R.; Essabbah, H. [Hopital Sahloul, Sousse (Tunisia)

    2010-07-01

    Purpose: evaluate the influence of the respiratory movements on the determination of activity and radioactive injury volume and the contribution of the respiratory synchronization to correct the artefacts induced by this movement. Conclusions: the respiratory movement is responsible of a significant reduction of the SUV{sub max} and and increase of the hyper-metabolic volume. Our work confirms the great robustness of the SUV{sub max} for semi-quantitative analysis, making it reliable for the therapy follow-up. (N.C.)

  2. Application of a respiratory synchronization method with hepatic imaging by PET- {sup 18}F-F.D.G; Application d'une methode de synchronisation respiratoire a l'imagerie hepatique par TEP au 18F-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Fin, L.; Daouk, J.; Morvan, J.; El-Esper, I.; Meyer, M.E. [Service de medecine nucleaire, CHU d' Amiens, (France); Regimbeau, J.M. [service de chirurgie generale viscerale et digestive, CHU d' Amiens, (France)

    2009-05-15

    The PET acquisition last several minutes, leading to confusing in the organs images in movement, especially the liver. We already described a method of treatment of acquisitions synchronized to the respiration (CT-based). We present now the complete case, coming from a current clinical study showing the interest of the application of this method for the hepatic pathologies. Conclusions: the removal of movement, with CT-based, improves the threshold of detection (i.e C/B) of injuries in a heterogenous medium such as the liver. The protocol of the current clinical study (50 forecasted inclusions) will allow to evaluate the sensitivity of the CT-based method for the hepatic pathologies. (N.C.)

  3. Unilateral brown fat on [{sup 18}F]-F.D.G. PET/CT in the follow-up of a pleural mesothelioma; Detection unilaterale de graisse brune en [{sup 18}F]-FDG TEP/TDM dans le suivi d'un mesotheliome pleural

    Energy Technology Data Exchange (ETDEWEB)

    Waele, A. de; Deroose, C.M. [Katholieke Universiteit Leuven, Hopitaux Universitaires de Leuven, UZ Leuven, Dept. de Medecine Nucleaire, Leuven (Belgium); Nafteux, P. [Katholieke Universiteit Leuven, Hopitaux Universitaires de Leuven, Dept. de Chirurgie Thoracique, Leuven (Belgium); Nackaerts, K. [Katholieke Universiteit Leuven, Hopitaux Universitaires de Leuven, Dept. de Pneumologie, Leuven (Belgium)

    2009-10-15

    The fixation of the fluorodeoxyglucose (F.D.G.) in the brown fat is generally characterized by a strongly symmetric setting in some areas of predilection.Is reported here the case of a patient that after having undergone a multi modal treatment for a pleural mesothelioma presents a unilateral F.D.G. fixation in the brown fat, this fixation can be inhibited by the administering of a beta adrenergic blocking agent. (N.C.)

  4. Interest of the PET/F.D.G. in the extension evaluation of patients having a hepatic tumor before intra-arterial metabolic radiotherapy; Interet de la TEP-FDG dans le bilan d'extension des patients atteints de tumeur hepatique avant radiotherapie metabolique intra-arterielle

    Energy Technology Data Exchange (ETDEWEB)

    Garin, E.; Devillers, A.; Ledortz, L.; Bahri, H.; Lecloirec, J.; Herry, J.Y. [Service de medecine nucleaire, centre Eugene-Marquis, Rennes, (France); Rolland, J.Y. [service de radiologie, centre Eugene-Marquis, Rennes, (France); Boucherc, E.; Raoul, J.L. [service d' oncologie digestive, centre Eugene-Marquis, Rennes, (France)

    2009-05-15

    In spite of a low sensitivity in the detection of C.H.C., the PET/F.D.G. allowed to detect a tumoral extension more important that this one suspected on the conventional evaluation for 30% of patients, either by finding a more important intra hepatic extension, or by finding extra hepatic extensions. Particularly, it allowed to detect metastases when the primitive tumor did not fix or very weakly the F.D.G. (N.C.)

  5. The PET-F.D.G. predicts the high grade recurrent gliomas survival treated by the association of bevacizumab-irinotecan; La TEP-FDG predit la survie des gliomes de haut grade recidivants traites par l'association bevacizumab-irinotecan

    Energy Technology Data Exchange (ETDEWEB)

    Colavolpe, C.; Guedj, E.; Mancini, J.; Bequet-Boucard, C.; Metellus, P.; Barrie, M.; Figarella-Branger, D.; Chinot, O.; Mundler, O. [CHU La Timone, Marseille, (France)

    2009-05-15

    The objective is to evaluate the prognosis value independent of the PET-F.D.G. on the global survival and without progression of recurred high grade gliomas treated by bevacizumab and irinotecan, in comparison with the others prognosis factors of the recurrence. In conclusions, the comparison of the F.D.G. fixation between the tumor area and contralateral one before anti-angiogenic treatment has a prognosis value independent on the global survival and without progression of recurred high grade gliomas treated by bevacizumab/irinotecan. (N.C.)

  6. Feasibility of an early dynamic acquisition in PET-F.D.G. to evaluate the prognosis of epidermoid carcinomas of superior aero digestive pathways; Faisabilite d'une acquisition dynamique precoce en TEP-FDG pour l'evaluation pronostique des carcinomes epidermoides des VADS

    Energy Technology Data Exchange (ETDEWEB)

    Abgral, R.; Le Roux, P.Y.; Querellou, S.; Turzo, A.; Salaun, P.Y. [CHU de Brest, Service de medecine nucleaire, 29 (France); Valette, G.; Potard, G.; Marianowski, R. [CHU de Brest, Service d' oto-rhinolaryngologie, 29 (France); Conan-Charlet, V. [CHU de Brest, Service d' anatomopathologie, 29 (France); Moser, E. [Centre hospitalier de Quimper, service de radiotherapie, 29 (France)

    2010-07-01

    purpose: evaluate the feasibility of an early dynamic acquisition in PET-F.D.G. in the staging of squamous cell carcinomas of upper aero digestive tract. Extract kinetics parameters of F.D.G. tumor uptake and compare them to SUV{sub max} at 60 minutes (prognosis value recognized but without established cut-off) and to {Delta}SUV{sub max} (1-2 h). Conclusions: The results of our study demonstrates the realisation feasibility of a early 60 minutes dynamic acquisition in PET-F.D.G. at the cervical level, allowing to get a kinetic parameter (initial slope) independent of the SUV{sub max} simple measure at 1 h and to envisage to compare their respective prognosis value in the initial evaluation of epidermoid carcinomas of superior aero digestive pathways. (N.C.)

  7. Molecular cloning of precursors for TEP-1 and TEP-2: The GGNG peptide-related peptides of a prosobranch gastropod, Thais clavigera.

    Science.gov (United States)

    Morishita, Fumihiro; Furukawa, Yasuo; Kodani, Yu; Minakata, Hiroyuki; Horiguchi, Toshihiro; Matsushima, Osamu

    2015-06-01

    TEP (Thais excitatory peptide)-1 and TEP-2 are molluscan counterparts of annelidan GGNG-peptides, identified in a neogastropod, Thais clavigera (Morishita et al., 2006). We have cloned two cDNAs encoding TEP-1 and TEP-2 precursor protein, respectively, by the standard molecular cloning techniques. Predicted TEP-1 precursor protein consists of 161 amino acids, while predicted TEP-2 precursor protein has 118 amino acids. Only a single copy of TEP was found on the respective precursor. The semi-quantitative RT-PCR showed that expression of TEP-1 was high in sub-esophageal, pleural, pedal and visceral ganglia, while it was low in supra-esophageal ganglion. By contrast, expression level of TEP-2 was high in pedal and visceral ganglia. In situ hybridization visualized different subsets of TEP-1 and TEP-2 expressing neurons in Thais ganglia. For example, supra-esophageal ganglion contained many TEP-2 expressing neuron, but not TEP-1 expressing ones. These results suggest that expression of TEP-1 and TEP-2 is differently regulated in the Thais ganglia. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Myositis ossificans: a false positive of malignancy in PET - CT F.D.G. and in osseous scintigraphy with HMDP {sup 99}Tc;La myosite ossifiante: un faux positif de malignite en TEP-TDM FDG et en scintigraphie osseuse au HMDP Tc99

    Energy Technology Data Exchange (ETDEWEB)

    Hassler, S.; Bourahla, K. [CLCC Paul-Strauss, Service de medecine nucleaire, 67 - Strasbourg (France)

    2010-05-15

    Myositis ossificans is a difficult differential diagnosis and a false positive for malignancy in both {sup 99m}Tc H.M.D.P. (hydroxy-methylene diphosphonate) scintigraphy and in exploration PET-F.D.G. This hypothesis should be mentioned in case of young patients, despite the unusual scintigraphic appearance in a benign process. (N.C.)

  9. False positive of the PET -CT with {sup 18}F.D.G. in the staging of Hodgkin lymphomas: about two cases;Faux positifs de la TEP-TDM au 18 FDG dans la stadification des lymphomes de hodgkin: a propos de deux cas

    Energy Technology Data Exchange (ETDEWEB)

    Caoduro, C.; Blagosklonov, O.; Angoue, O.; Ungureanu, C.M.; Quemard, G.; Porot, C.; Boulahdour, H. [Hopital Jean-Minjoz, Service de medecine nucleaire, 25 - Besancon (France); Lerais, J.M. [Hopital Jean-Minjoz, Service de radiologie, 25 - Besancon (France)

    2010-05-15

    An isolated hyper fixating bone lesion on a PET / CT performed for staging of lymphoma should suggest a false positive and take advantage of additional tests for etiological aim to allow proper staging of the disease and appropriate therapy. (N.C.)

  10. The PET-T.D.M. with 18-F.D.G. allows to identify the A and B stages of chronic lymphoid leukemia; La TEP-TDM au 18-FDG permet d'identifier les stades A et B des leucemies lymphoides chroniques

    Energy Technology Data Exchange (ETDEWEB)

    Berthelot, C.B.; Cahouet, A.C.; Lacoeuille, F.L.; Vervueren, L.V.; Rakotonirina, H.R.; Le Jeune, J.L.; Couturier, O.C. [Service de medecine nucleaire, CHU d' Angers, (France)

    2009-05-15

    The aim of this study is to evaluate the the PET-F.D.G. in the stages A and B of Chronic lymphoid leukemia. The ganglions hyper fixations are constant for the stages B and more intense than at the stages A. These abnormalities are always symmetric, contrary to what is observed in the Richter transformations. The threshold value of 1.33 for the axillary SUV{sub max} (standardized uptake value) allows to distinguish with a strong reliability the stages A from the stages B. (N.C.)

  11. Is the irradiation of paramedical personnel of care service by patients having benefited of a PET with 18 F.D.G. acceptable?; L'irradiation des personnels paramedicaux des services de soins par les patients ayant beneficie d'une TEP au 18FDG est-elle acceptable?

    Energy Technology Data Exchange (ETDEWEB)

    Salmon, F.; Desmarquet, M.; Voix, F.; Muller, P.; Jonquet, C.; Perdrisot, R. [GIE Positon Poitou-Charentes, CHU de Poitiers, (France); Gachignard, A. [GIE Positon Poitou- Charentes, polyclinique de Poitiers, (France)

    2009-05-15

    The come back of hospitalized patients having received a PET scintigraphy with {sup 18}F-F.D.G. towards the care services occurs some minutes after the examination, after checking the acquisition quality. We wonder about the legitimacy of this procedure, in consideration to the particularly intense dosimetry of this tracer. In conclusions: This estimation shows that the doses received by the personnel of care services are acceptable, but suggest different axes of thinking: the reduction of the dose injected to the patients, the turnover of the personnel that manage the patients receiving PET examinations, the classification of paramedical personnel in class B personnel, the ability to keep the patients that have benefited of a PET examination during a two hours period after the procedure. This preliminary study should be followed by a post study by operational dosimetry targeting that paramedical personnel giving the care close to the patients having benefiting of a PET procedure. (N.C.)

  12. Contribution of the PET-CT with {sup 18}F.D.G. in the non metastatic thyroid cancers with suspicion of residual or recurrent disease; Apport de la TEP-TDM au {sup 18}FDG dans les cancers de la thyroide non metastatiques avec suspicion de maladie residuelle ou recidivante

    Energy Technology Data Exchange (ETDEWEB)

    Ghander, C.; Taieb, D.; Tessonnier, L.; Mundler, O. [CHU Timone, Service central de biophysique et de medecine nucleaire, 13 - Marseille (France); Sebag, F.; Henry, J.F. [CHU Timone, service central de chirurgie generale et endocrinienne, 13 - Marseille (France); De Micco, C. [Inserm U555, service d' anatomopathologie, 13 - Marseille (France)

    2010-07-01

    Purpose: Recurrent thyroid carcinomas usually involve the cervical lymph nodes. The objective of this study was to evaluate the contribution of {sup 18}F-F.D.G. PET in the investigation of thyroid cancer compared with non-metastatic cervical echography. Conclusions: Due to the low overall sensitivity of PET / CT in thyroid carcinoma, its use should be reserved for cases of aggressive carcinoma and when the residual thyroglobulin under stimulation is high. In these cases it is a complementary information with neck echography. (N.C.)

  13. Distribution of Transparent Exopolymer Particles (TEP) and TEP-Carbon content in the North Sea in summer

    Science.gov (United States)

    Anastasi, G.; Greenwood, N.; Malin, G.; Bakker, D. C. E.; Polimene, L.; Johnson, M.

    2016-02-01

    A key requirement for the quantitative assessment of the global marine carbon cycle is to improve understanding of the regulation of dissolved organic carbon (DOC) concentrations. Continental shelf seas make an important contribution to sequestration of CO2 from the atmosphere, through physical and biological processes, ie. the Continental Shelf Pump (CSP). The role of organic matter dynamics in the CSP is poorly understood. Decoupling the carbon to nitrogen stoichiometry of organic matter production from that of the primary producers can lead to excess uptake of dissolved carbon relative to nitrogen, allowing for `overconsumption' of carbon and increased biological pump efficiency. This process could be particularly effective if carbon-rich material such as gel-like transparent exopolymer particles (TEP) are formed as these can sink out of the surface layer. The aim of this project is to understand the role of dissolved organic matter (DOM) and TEP production in carbon overconsumption in shelf seas. To this end, a combined experimental-modelling approach was used. TEP samples collected in the North Sea in August 2014 were analysed to obtain a detailed snapshot of TEP distribution in summer. A new parameterisation was derived for the representation of TEP-C in the the European Regional Seas Ecosystem Model (ERSEM) in order to investigate the mechanism governing the production and sinking of TEP. Our results show concentrations of TEP-C close to the value for overconsumption of dissolved inorganic carbon (DIC) predicted by Prowe at al. (2009) for the North Sea in summer. A clear relationship between TEP-C and chlorophyll was observed. ERSEM was able to quantitatively reproduce the observed TEP-C concentrations and simulate the seasonal cycle at a North Sea site, along with a likely sinking pattern of TEP-C. These results suggest that qualitative or quantitative changes in TEP production could have considerable influence on the efficiency of the CSP and carbon export.

  14. TEP Power Partners Project [Tucson Electric Power

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2014-02-06

    The Arizona Governor’s Office of Energy Policy, in partnership with Tucson Electric Power (TEP), Tendril, and Next Phase Energy (NPE), formed the TEP Power Partners pilot project to demonstrate how residential customers could access their energy usage data and third party applications using data obtained from an Automatic Meter Reading (AMR) network. The project applied for and was awarded a Smart Grid Data Access grant through the U.S. Department of Energy. The project participants’ goal for Phase I is to actively engage 1,700 residential customers to demonstrate sustained participation, reduction in energy usage (kWh) and cost ($), and measure related aspects of customer satisfaction. This Demonstration report presents a summary of the findings, effectiveness, and customer satisfaction with the 15-month TEP Power Partners pilot project. The objective of the program is to provide residential customers with energy consumption data from AMR metering and empower these participants to better manage their electricity use. The pilot recruitment goals included migrating 700 existing customers from the completed Power Partners Demand Response Load Control Project (DRLC), and enrolling 1,000 new participants. Upon conclusion of the project on November 19, 2013; 1,390 Home Area Networks (HANs) were registered; 797 new participants installed a HAN; Survey respondents’ are satisfied with the program and found value with a variety of specific program components; Survey respondents report feeling greater control over their energy usage and report taking energy savings actions in their homes after participating in the program; On average, 43 % of the participants returned to the web portal monthly and 15% returned weekly; and An impact evaluation was completed by Opinion Dynamics and found average participant savings for the treatment period1 to be 2.3% of their household use during this period.2 In total, the program saved 163 MWh in the treatment period of 2013.

  15. Atypical false negative results of {sup 67}Ga scintigraphy and {sup 18}F-F.D.G. PET-CT in a patient with sarcoidosis and bilateral breast cancer; Resultats atypiques et faux-negatifs de la scintigraphie au {sup 67}Ga et de la TEP-TDM au {sup 18}F-FDG chez une patiente avec sarcoidose et cancer du sein bilateral

    Energy Technology Data Exchange (ETDEWEB)

    Keomany, J.; Imperiale, A.; Constantinesco, A. [Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, Service de Biophysique et de Medecine Nucleaire, 67 - Strasbourg (France); Thiriat, S. [Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, Service de Radiologie, 67 - Strasbourg (France); Braun, J.J. [Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, Service d' ORL, 67 - Strasbourg (France)

    2009-12-15

    We describe the case of a patient with biopsy proven sino-nasal sarcoidosis and a bilateral breast cancer that was unknown at the time of {sup 67}Ga scintigraphy and {sup 18}F-F.D.G. PET-CT. {sup 67}Ga scintigraphy showed low sensibility in the assessment of sarcoidosis localizations. Conversely, multiple foci of intense {sup 18}F-F.D.G. uptake were assessed suggesting the presence of active granulomatous disease in sino-nasal region, rhino pharynx, skin and several peripheral lymphadenopathy, which were not previously detected by conventional evaluation. On the other hand, an atypical focal accumulation of {sup 67}Ga uptake was showed in right breast parenchyma, proving to be a grade III infiltrating canalar carcinoma coexistent with pleomorphic type, without axillary metastatic lymphadenopathy. Surprisingly, no {sup 18}F-F.D.G. uptake abnormalities were detected in the right breast in correspondence of {sup 67}Ga pathological uptake. The whole of these results is discussed according to histological nature of the lesions and the data of the literature. (authors)

  16. Contribution of the respiratory synchronization during the PET/CT with {sup 18}F-F.D.G. to characterize thorax injuries; Apport de la synchronisation respiratoire au cours de la TEP/TDM au {sup 18}F-FDG pour la caracterisation des lesions thoraciques

    Energy Technology Data Exchange (ETDEWEB)

    Farid, K.; Caillat-Vigneron, N. [Hotel-Dieu de Paris, Servce de medecine nucleaire, 75 - (France); Petras, S.; Servois, V. [Institut Curie, Departement d' imagerie, 75 - Paris (France)

    2010-07-01

    Purpose: organs moving introduce a vagueness in scintigraphy images, degrading their quality and the signal/noise ratio. The injuries appear bigger, the tracer uptake inside the tumor is underestimated. Methods synchronized to respiration have been applied for quantitative analysis. The purpose of this study is to evaluate the interest of this respiratory synchronization on the nodules S.U.V. variation and/ or of pulmonary masses before therapy decision. Conclusions: Trying to get rid of motion artifacts using respiratory gating method improves the signal/noise ratio (S.N.R.), the quantitative assessment with a significant increase in the value of the S.U.V. and therefore the characterization of thoracic lesions. (N.C.)

  17. Macrophage activation syndrome and PET with {sup 18}F-F.D.G. in a context of a prolonged fever; Syndrome d'activation macrophagique et TEP au 18F-FDG dans un contexte de fievre au long cours

    Energy Technology Data Exchange (ETDEWEB)

    Deshayes, E.; Janier, M.; Billotey, C. [Hopital Edouard-Herriot, Service de medecine nucleaire, 69 - Lyon (France); Hot, A. [Hopital Edouard-Herriot, Service de medecine interne, 69 - Lyon (France); Adham, M.; Parmentier, B. [Hopital Edouard-Herriot, federation des specialites digestives, 69 - Lyon (France); Girard, S. [Hopital Edouard-Herriot, service d' hematologie biologique, 69 - Lyon (France)

    2010-07-01

    Purpose: Think to the diagnosis, a rare but often fatal hemo phagocytic syndrome before an intense and diffuse bone marrow uptake in homogenous PET{sup 18}F-F.D.G.. The place of PET {sup 18}F-F.D.G. in the diagnosis of fever in the long term is growing. In this context, nuclear physicians and clinicians need to suspect to the diagnosis of hemo phagocytic syndrome. (N.C.)

  18. TEP and Lichtenstein anatomy: does simulation accelerate acquisition among interns?

    Science.gov (United States)

    Rowse, P G; Ruparel, R K; Abdelsattar, J M; AlJamal, Y N; Dy, B M; Farley, D R

    2016-06-01

    The anatomy of the inguinal region is notoriously challenging to master. We sought to teach open inguinal hernia (OIH) and totally extraperitoneal (TEP) anatomy with simulation models among general surgery (GS) interns. Low-fidelity OIH and TEP models were constructed out of cardboard, plastic bins, fabric, and yarn. GS interns (n = 30) participated in a 3-h hernia session including a pretest, anatomy lecture, simulated OIH and TEP hernia repair, and posttest. Pre- and posttest scores were based on a difficult 30-point exam which included didactic questions (10 points), drawing relevant TEP (10 points), and OIH (10 points) anatomy. Participants were surveyed following the session. Median pretest scores were 13 % (range 0-60 %). Median posttest scores improved to 47 % (range 20-93 %, p TEP image improved from 2 (range 0-14) to 11 (range 1-21, p TEP anatomy (4.4, 4.2). Low-fidelity simulators can be used to teach and assess knowledge of TEP and OIH anatomy. While enjoyable and useful, one 3-h session does not create master hernia surgeons or expert anatomists out of novice trainees.

  19. Prochlorococcus as a Possible Source for Transparent Exopolymer Particles (TEP)

    KAUST Repository

    Agusti, Susana

    2017-04-26

    Transparent exopolymer particles (TEP), usually associated with phytoplankton blooms, promote the formation of marine aggregates. Their exportation to deep waters is considered a key component of the biological carbon pump. Here, we explored the role of solar radiation and picocyanobacteria in the formation of TEP in oligotrophic surface waters of the Atlantic and Pacific Oceans in ten on-deck incubation experiments during the Malaspina 2010 Expedition. TEP concentrations were low on the ocean’s surface although these concentrations were significantly higher on the surface of the Pacific (24.45 ± 2.3 μg XG Eq. L-1) than on the surface of the Atlantic Ocean (8.18 ± 4.56 μg XG Eq. L-1). Solar radiation induced a significant production of TEP in the on-deck experiments from the surface water of the Pacific Ocean, reaching values up to 187.3 μg XG Eq. L-1 compared with the low production observed in the dark controls. By contrast, TEP production in the Atlantic Ocean experiments was lower, and its formation was not related to the light treatments. Prochlorococcus sp. from the surface ocean was very sensitive to solar radiation and experienced a high cell decay in the Pacific Ocean experiments. TEP production in the on-deck incubation experiments was closely related to the observed cell decay rates of Prochlorococcus sp., suggesting that this picocyanobacteria genus is a potential source of TEP. The evidence to propose such potential role was derived experimentally, using natural communities including the presence of several species and a variety of processes. Laboratory experiments with cultures of a non-axenic strain of Prochlorococcus marinus were then used to test TEP production by this genus. TEP concentrations in the culture increased with increasing cell abundance during the exponential phase, reaching the highest TEP concentration at the beginning of the stationary phase. The average TEP concentration of 1474 ± 226 μg XG Eq. L-1 (mean ± SE) observed at

  20. Prochlorococcus as a Possible Source for Transparent Exopolymer Particles (TEP).

    Science.gov (United States)

    Iuculano, Francesca; Mazuecos, Ignacio P; Reche, Isabel; Agustí, Susana

    2017-01-01

    Transparent exopolymer particles (TEP), usually associated with phytoplankton blooms, promote the formation of marine aggregates. Their exportation to deep waters is considered a key component of the biological carbon pump. Here, we explored the role of solar radiation and picocyanobacteria in the formation of TEP in oligotrophic surface waters of the Atlantic and Pacific Oceans in ten on-deck incubation experiments during the Malaspina 2010 Expedition. TEP concentrations were low on the ocean's surface although these concentrations were significantly higher on the surface of the Pacific (24.45 ± 2.3 μg XG Eq. L-1) than on the surface of the Atlantic Ocean (8.18 ± 4.56 μg XG Eq. L-1). Solar radiation induced a significant production of TEP in the on-deck experiments from the surface water of the Pacific Ocean, reaching values up to 187.3 μg XG Eq. L-1 compared with the low production observed in the dark controls. By contrast, TEP production in the Atlantic Ocean experiments was lower, and its formation was not related to the light treatments. Prochlorococcus sp. from the surface ocean was very sensitive to solar radiation and experienced a high cell decay in the Pacific Ocean experiments. TEP production in the on-deck incubation experiments was closely related to the observed cell decay rates of Prochlorococcus sp., suggesting that this picocyanobacteria genus is a potential source of TEP. The evidence to propose such potential role was derived experimentally, using natural communities including the presence of several species and a variety of processes. Laboratory experiments with cultures of a non-axenic strain of Prochlorococcus marinus were then used to test TEP production by this genus. TEP concentrations in the culture increased with increasing cell abundance during the exponential phase, reaching the highest TEP concentration at the beginning of the stationary phase. The average TEP concentration of 1474 ± 226 μg XG Eq. L-1 (mean ± SE) observed at

  1. Prochlorococcus as a Possible Source for Transparent Exopolymer Particles (TEP

    Directory of Open Access Journals (Sweden)

    Susana Agustí

    2017-04-01

    Full Text Available Transparent exopolymer particles (TEP, usually associated with phytoplankton blooms, promote the formation of marine aggregates. Their exportation to deep waters is considered a key component of the biological carbon pump. Here, we explored the role of solar radiation and picocyanobacteria in the formation of TEP in oligotrophic surface waters of the Atlantic and Pacific Oceans in ten on-deck incubation experiments during the Malaspina 2010 Expedition. TEP concentrations were low on the ocean’s surface although these concentrations were significantly higher on the surface of the Pacific (24.45 ± 2.3 μg XG Eq. L-1 than on the surface of the Atlantic Ocean (8.18 ± 4.56 μg XG Eq. L-1. Solar radiation induced a significant production of TEP in the on-deck experiments from the surface water of the Pacific Ocean, reaching values up to 187.3 μg XG Eq. L-1 compared with the low production observed in the dark controls. By contrast, TEP production in the Atlantic Ocean experiments was lower, and its formation was not related to the light treatments. Prochlorococcus sp. from the surface ocean was very sensitive to solar radiation and experienced a high cell decay in the Pacific Ocean experiments. TEP production in the on-deck incubation experiments was closely related to the observed cell decay rates of Prochlorococcus sp., suggesting that this picocyanobacteria genus is a potential source of TEP. The evidence to propose such potential role was derived experimentally, using natural communities including the presence of several species and a variety of processes. Laboratory experiments with cultures of a non-axenic strain of Prochlorococcus marinus were then used to test TEP production by this genus. TEP concentrations in the culture increased with increasing cell abundance during the exponential phase, reaching the highest TEP concentration at the beginning of the stationary phase. The average TEP concentration of 1474 ± 226 μg XG Eq. L-1 (mean

  2. [F18]-FDG imaging of experimental animal tumours using a hybrid gamma-camera; Imagerie au [18F]-FDG des tumeurs experimentales du petit animal de laboratoire a l'aide d'une gamma-camera hybride optimisee pour la scintigraphie chez l'homme

    Energy Technology Data Exchange (ETDEWEB)

    Lausson, S. [Institut National de la Sante et de la Recherche Medicale (INSERM U349) - Hopital Lariboisiere, 75 - Paris (France); Maurel, G.; Kerrou, K.; Montravers, F.; Petegnief, Y.; Talbot, J.N. [Universite Pierre et Marie Curie, Dept. de Biophysique, Faculte de Medecine St Antoine, Service de Medecine Nucleaire, Hopital Tenon, AP-HP, 75 - Paris (France); Fredelizi, D. [Institut National de la Sante et de la Recherche Medicale (INSERM U477) - Hopital Cochin, 75 - Paris (France)

    2001-07-01

    Positron emission tomography (PET) has been widely used in clinical studies. This technology permits detection of compounds labelled with positron emitting radionuclides and in particular, [F18]-fluorodeoxyglucose ([F18]-FDG).[F18]-FDG uptake and accumulation is generally related to malignancy; some recent works have suggested the usefulness of PET camera dedicated to small laboratory animals (micro-PET). Our study dealt with the feasibility of [F18]-FDG imaging of malignant tumours in animal models by means of an hybrid camera dedicated for human scintigraphy. We evaluated the ability of coincidence detection emission tomography (CDET) using this hybrid camera to visualize in vivo subcutaneous tumours grafted to mice or rats. P815 murine mastocytoma grafted in syngeneic DBA/2 mice resulted with foci of very high FDG uptake. Tumours with a diameter of only 3 mm were clearly visualized. Medullary thyroid cancer provoked by rMTC 6/23 and CA77 lines in syngeneic Wag/Rij rat was also detected. The differentiated CA77 tumours exhibited avidity for [F18]-FDG and a tumour, which was just palpable (diameter lower than 2 mm), was identified. In conclusion, CDET-FDG is a non-invasive imaging tool which can be used to follow grafted tumours in the small laboratory animal, even when their size is smaller than 1 cm. It has the potential to evaluate experimental anticancer treatments in small series of animals by individual follow-up. It offers the opportunity to develop experimental PET research within a nuclear medicine or biophysics department, the shift to a dedicated micro-PET device being subsequently necessary. It is indeed compulsory to strictly follow the rules for non contamination and disinfection of the hybrid camera. (authors)

  3. Development of Advanced Thermal ana Electric Propulsion (TEP) System

    National Research Council Canada - National Science Library

    Tabibi, Bagher

    1994-01-01

    On September 30, 1993, the Department of Physics at Hampton University was awarded a research instrumentation grant by the AFOSR for the development of an advanced Thermal and Electric Propulsion (TEP) system...

  4. Transparent exopolymer particle (TEP) dynamics in the eastern Mediterranean Sea

    National Research Council Canada - National Science Library

    E. Bar-Zeev; T. Berman; E. Rahav; G. Dishon; B. Herut; N. Kress; I. Berman-Frank

    2011-01-01

    Depth and spatial distribution patterns of transparent exopolymer particles (TEP) were measured during 2 east to west cruise transects across the ultra-oligotrophic Levantine basin, eastern Mediterranean Sea...

  5. Effectiveness of seawater reverse osmosis (SWRO) pretreatment systems in removing transparent exopolymer particles (TEP) substances

    KAUST Repository

    Lee, Shang-Tse

    2015-05-01

    Transparent exopolymer particles (TEP) have been reported as one of the main factors of membrane fouling in seawater reverse osmosis (SWRO) process. Research has been focused on algal TEP so far, overlooking bacterial TEP. This thesis investigated the effects of coagulation on removal of bacterial TEP/TEP precursors in seawater and subsequent reduction on TEP fouling in ultrafiltration (UF), as a pretreatment of SWRO. Furthermore, the performance of pretreatment (coagulation + UF) has been investigated on a bench-scale SWRO system. TEP/TEP precursors were harvested from a strain of marine bacteria, Pseudoalteromonas atlantica, isolated from the Red Sea. Isolated bacterial organic matter (BOM), containing 1.5 mg xanthan gum eq./L TEP/TEP precursors, were dosed in Red Sea water to mimic a high TEP concentration event. Bacterial TEP/TEP precursors added to seawater were coagulated with ferric chloride and aluminum sulfate at different dosages and pH. Results showed that ferric chloride had a better removal efficiency on TEP/TEP precursors. Afterwards, the non-coagulated/coagulated seawater were tested on a UF system at a constant flux of 130 L/m2h, using two types of commercially available membranes, with pore sizes of 50 kDa and 100 kDa, respectively. The fouling potential of coagulated water was determined by the Modified Fouling Index (MFI-UF). Transmembrane pressure (TMP) was also continuously monitored to investigate the fouling development on UF membranes. TEP concentrations in samples were determined by the alcian blue staining assay. Liquid chromatography-organic carbon detection (LC-OCD) was used to determine the removal of TEP precursors with particular emphasis on biopolymers. Finally, SWRO tests showed that TEP/TEP precursors had a high fouling potential as indicated by MFI-UF, corresponding to the TMP measurements. Coagulation could substantially reduce TEP/TEP precursors fouling in UF when its dosage was equal or higher than 0.2 mg Fe/L. The flux decline

  6. Detection of occult cancer with [{sup 18}F]-FDG scintigraphy in case of limbic encephalitis, a rare neurologic para neoplastic syndrome; Detection du cancer occulte a l'aide de la scintigraphie au [{sup 18}F]-FDG en cas d'encephalite limbique, un syndrome neurologique paraneoplasique rare

    Energy Technology Data Exchange (ETDEWEB)

    Kerrou, K.; Aide, N.; Montravers, F.; Grahek, D.; Younsi-Pourtau, N.; Petegnief, Y.; Colombet-Lamau, C.; Beco, V. de; Talbot, J.N. [Hopital Tenon, Service de Medecine Nucleaire, et Centre TEP AP-HP, 75 - Paris (France)

    2003-07-01

    Limbic encephalitis is a rare neurologic para-neoplastic syndrome due to the production of anti-neuronal antibodies induced by the presence of a malignant tumour, most frequently a small cell lung cancer: The discovery and the resection of the malignant tissue allows a stabilisation of the neurological syndrome, a complete recovery being impossible when irreversible lesions are present. ({sup 18}F)-FDG PET may play a determinant role when the cancer is still occult after conventional imaging work-up. We report here on a such patient with evolving limbic encephalitis and no detectable cancer with conventional imaging modalities. ({sup 18}F)-FDG CDET successfully localised neoplastic small cell lung cancer tissue in the lung. The malignant tumour was not even detectable at surgery and was only confirmed at post surgical histology exactly exactly where it has been spotted by CDET. After surgery, the neurologic syndrome is now steady. (authors)

  7. FDG accumulation and tumor biology

    Energy Technology Data Exchange (ETDEWEB)

    Pauwels, E.K.J.; Ribeiro, M.J.; Stoot, J.H.M.B.; McCready, V.R.; Bourguignon, M.; Maziere, B

    1998-05-01

    The tumoral uptake of fluorine-18-deoxyglucose (FDG) is based upon enhanced glycolysis. Following injection, FDG is phosphorylated and trapped intracellularly. An important mechanism to transport FDG into the transformed cell is based upon the action of glucose transporter proteins; furthermore, highly active hexokinase bound to tumor mitochondria helps to trap FDG into the cell. In addition, enhanced FDG uptake may be due to relative hypoxia in tumor masses, which activates the anaerobic glycolytic pathway. In spite of these processes, FDG uptake is relatively aspecific since all living cells need glucose. Clinical use is therefore recommended in carefully selected patients.

  8. Carbon and nitrogen content of transparent exopolymer particles (TEP) in relation to their Alcian Blue adsorption

    OpenAIRE

    Engel, Anja; Passow, Uta

    2001-01-01

    The carbon and nitrogen content of transparent exopolymer particles (TEP) was determined and related to the concentration of TEP as quantified by a colorimetrical method. TEP were produced in the laboratory from dissolved precursors by laminar or turbulent shear. Dissolved precursors were obtained by 0.2 µm filtration from diatom cultures, with or without nutrient reduction, and from natural diatom populations. The relationship between carbon and TEP was significant, linear and species-specif...

  9. Laparoscopic Repair of Inguinal Hernia TEP versus TAPP.

    Science.gov (United States)

    Vărcuş, Flore; Duţă, Ciprian; Dobrescu, Amadeus; Lazăr, Fuger; Papurica, Marius; Tarta, Cristi

    2016-01-01

    The purpose of the study was to compare the results of laparoscopic inguinal hernia repair using two different methods: transabdominal preperitoneal (TAPP) repair and the technique of totally extraperitoneal repair (TEP). In this retrospective study were included 90 cases of inguinal hernia that underwent for laparoscopic approach of inguinal hernia repair at the Emergency County Hospital Timisoara at the 2nd Surgical Clinic between 2012 and 2013. The primary outcome was recurrence of the hernia at two years follow-up. Secondary outcomes were short and long-term complications: hematoma and seroma formation, inflammation of the testis, chronic inguinal pain, reoperation, 30 days mortality. Of the 90 patients who underwent unilateral hernia repair, 70 were completely followed-up for 24 months, 36 (81.81%) patients with TEP and 34 (73.91%) with TAPP. Regarding the main outcome there was no recurrence of the hernia at two years follow-up.There were two cases of bleeding in the TAPP group;both were managed by laparoscopic sealing of the damaged vessels, 8 cases of post-operative edema of testis in TAPP and 3 cases in TEP. Regarding thesubcutaneous emphysema there were 16 cases in TAPP and 3 cases in TEP. Differences between TEP and TAPP in our study were related to minor complications, no major complications occurred. After the two years follow-up of 70 of a total of 90 patients, there was no recurrence of the hernia. Celsius.

  10. Evolution of the thioester-containing proteins (TEPs) of the arthropoda, revealed by molecular cloning of TEP genes from a spider, Hasarius adansoni.

    Science.gov (United States)

    Sekiguchi, Reo; Fujito, Naoko T; Nonaka, Masaru

    2012-02-01

    The thioester-containing protein (TEP) family of genes, found in most Eumetazoan genomes, is classified into two subfamilies: the alpha-2-macroglobulin (A2M) subfamily and the C3 subfamily. Many A2M subfamily members, including insect TEP (iTEP), have been reported from the Arthropoda, whereas the C3 subfamily members have been reported only from two horseshoe crab species thus far. To elucidate the evolution of these genes among the Arthropoda, TEP genes were isolated from a spider, Hasarius adansoni (Chelicerata), by reverse transcription polymerase chain reaction (RT-PCR) amplification using universal degenerate primers specific for the thioester region. Four different TEP genes were identified. Phylogenetic analysis using the entire amino acid sequences of these and various other TEP sequences from the Eumetazoa indicated that two of the spider genes are type C3 (HaadC3-1 and HaadC3-2), one is type A2M (HaadA2M) and the other is closely related to iTEP (HaadiTEP). These results suggest that the common ancestor of the Arthropoda possessed at least three TEP genes, C3, A2M and iTEP and that they were lost differentially in the Crustacean and Hexapodan lineages. Copyright © 2011 Elsevier Ltd. All rights reserved.

  11. CTS TEP thermal anomalies: Heat pipe system performance

    Science.gov (United States)

    Marcus, B. D.

    1977-01-01

    A part of the investigation is summarized of the thermal anomalies of the transmitter experiment package (TEP) on the Communications Technology Satellite (CTS) which were observed on four occasions in 1977. Specifically, the possible failure modes of the variable conductance heat pipe system (VCHPS) used for principal thermal control of the high-power traveling wave tube in the TEP are considered. Further, the investigation examines how those malfunctions may have given rise to the TEP thermal anomalies. Using CTS flight data information, ground test results, analysis conclusions, and other relevant information, the investigation concentrated on artery depriming as the most likely VCHPS failure mode. Included in the study as possible depriming mechanisms were freezing of the working fluid, Marangoni flow, and gas evolution within the arteries. The report concludes that while depriming of the heat pipe arteries is consistent with the bulk of the observed data, the factors which cause the arteries to deprime have yet to be identified.

  12. Toroidal Energy Principle (TEP) and perturbed equilibrium code STB

    Science.gov (United States)

    Zakharov, Leonid; Hu, Di

    2016-10-01

    The MHD energy principle TEP is presented in terms of perturbations of the vector potential, rather than plasma displacement. This form makes TEP capable to discribe both the ideal plasmas stability and the perturbed equilibria. The functional is expressed in two terms. The first one represents the energy of magnetic field and is calculated using working equilibrium coordinate system. The second term, containing plasma displacement is expressed in the compact form using Hamada coordinates. This representation uses the same combinations of metric coefficients as in the equilibrium calculations. The STB code implements the TEP for both ideal MHD and perturbed equilibria. In the first case, it uses the matching conditions of the ideal MHD. In the second case, the 2-D equilibrium islands are introduced in order to resolve the singularity and match the solutions across the resonant surfaces Partially by (a) US DoE Contract No. DE-AC02-09-CH11466, (b) General Fusion Inc.

  13. Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae.

    Science.gov (United States)

    Volohonsky, Gloria; Hopp, Ann-Katrin; Saenger, Mélanie; Soichot, Julien; Scholze, Heidi; Boch, Jens; Blandin, Stéphanie A; Marois, Eric

    2017-01-01

    Mosquitoes genetically engineered to be resistant to Plasmodium parasites represent a promising novel approach in the fight against malaria. The insect immune system itself is a source of anti-parasitic genes potentially exploitable for transgenic designs. The Anopheles gambiae thioester containing protein 1 (TEP1) is a potent anti-parasitic protein. TEP1 is secreted and circulates in the mosquito hemolymph, where its activated cleaved form binds and eliminates malaria parasites. Here we investigated whether TEP1 can be used to create malaria resistant mosquitoes. Using a GFP reporter transgene, we determined that the fat body is the main site of TEP1 expression. We generated transgenic mosquitoes that express TEP1r, a potent refractory allele of TEP1, in the fat body and examined the activity of the transgenic protein in wild-type or TEP1 mutant genetic backgrounds. Transgenic TEP1r rescued loss-of-function mutations, but did not increase parasite resistance in the presence of a wild-type susceptible allele. Consistent with previous reports, TEP1 protein expressed from the transgene in the fat body was taken up by hemocytes upon a challenge with injected bacteria. Furthermore, although maturation of transgenic TEP1 into the cleaved form was impaired in one of the TEP1 mutant lines, it was still sufficient to reduce parasite numbers and induce parasite melanization. We also report here the first use of Transcription Activator Like Effectors (TALEs) in Anopheles gambiae to stimulate expression of endogenous TEP1. We found that artificial elevation of TEP1 expression remains moderate in vivo and that enhancement of endogenous TEP1 expression did not result in increased resistance to Plasmodium. Taken together, our results reveal the difficulty of artificially influencing TEP1-mediated Plasmodium resistance, and contribute to further our understanding of the molecular mechanisms underlying mosquito resistance to Plasmodium parasites.

  14. Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae.

    Directory of Open Access Journals (Sweden)

    Gloria Volohonsky

    2017-01-01

    Full Text Available Mosquitoes genetically engineered to be resistant to Plasmodium parasites represent a promising novel approach in the fight against malaria. The insect immune system itself is a source of anti-parasitic genes potentially exploitable for transgenic designs. The Anopheles gambiae thioester containing protein 1 (TEP1 is a potent anti-parasitic protein. TEP1 is secreted and circulates in the mosquito hemolymph, where its activated cleaved form binds and eliminates malaria parasites. Here we investigated whether TEP1 can be used to create malaria resistant mosquitoes. Using a GFP reporter transgene, we determined that the fat body is the main site of TEP1 expression. We generated transgenic mosquitoes that express TEP1r, a potent refractory allele of TEP1, in the fat body and examined the activity of the transgenic protein in wild-type or TEP1 mutant genetic backgrounds. Transgenic TEP1r rescued loss-of-function mutations, but did not increase parasite resistance in the presence of a wild-type susceptible allele. Consistent with previous reports, TEP1 protein expressed from the transgene in the fat body was taken up by hemocytes upon a challenge with injected bacteria. Furthermore, although maturation of transgenic TEP1 into the cleaved form was impaired in one of the TEP1 mutant lines, it was still sufficient to reduce parasite numbers and induce parasite melanization. We also report here the first use of Transcription Activator Like Effectors (TALEs in Anopheles gambiae to stimulate expression of endogenous TEP1. We found that artificial elevation of TEP1 expression remains moderate in vivo and that enhancement of endogenous TEP1 expression did not result in increased resistance to Plasmodium. Taken together, our results reveal the difficulty of artificially influencing TEP1-mediated Plasmodium resistance, and contribute to further our understanding of the molecular mechanisms underlying mosquito resistance to Plasmodium parasites.

  15. The evolution of TEP1, an exceptionally polymorphic immunity gene in Anopheles gambiae

    Directory of Open Access Journals (Sweden)

    Yan Guiyun

    2008-10-01

    Full Text Available Abstract Background Host-parasite coevolution can result in balancing selection, which maintains genetic variation in the susceptibility of hosts to parasites. It has been suggested that variation in a thioester-containing protein called TEP1 (AGAP010815 may alter the ability of Anopheles mosquitoes to transmit Plasmodium parasites, and high divergence between alleles of this gene suggests the possible action of long-term balancing selection. We studied whether TEP1 is a case of an ancient balanced polymorphism in an animal immune system. Results We found evidence that the high divergence between TEP1 alleles is the product of genetic exchange between TEP1 and other TEP loci, i.e. gene conversion. Additionally, some TEP1 alleles showed unexpectedly low variability. Conclusion The TEP1 gene appears to be a chimera produced from at least two other TEP loci, and the divergence between TEP1 alleles is probably not caused by long-term balancing selection, but is instead due to two independent gene conversion events from one of these other genes. Nevertheless, TEP1 still shows evidence of natural selection, in particular there appears to have been recent changes in the frequency of alleles that has diminished polymorphism within each allelic class. Although the selective force driving this dynamic was not identified, given that susceptibility to Plasmodium parasites is known to be associated with allelic variation in TEP1, these changes in allele frequencies could alter the vectoring capacity of populations.

  16. Reduction of the {sup 18}FDG uptake by the brown fat with the help of propranolol in a difficult case of lymphoma with residual disease suspicion; Reduction de la captation du 18FDG par la graisse brune grace au propranolol dans un cas difficile de lymphome avec suspicion de maladie residuelle

    Energy Technology Data Exchange (ETDEWEB)

    Vervueren, L.; Berthelot, C.; Rakotonirina, H.; Lacoeuille, F.; Cahouet Vannier, A.; Le Jeune, J.J.; Couturier, O. [Service de medecine nucleaire et biophysique, CHU d' Angers, (France)

    2009-05-15

    The oncology group of the French Society of nuclear medicine implemented evaluation criteria of the lymphomas therapy response. The problem often encountered is this one of identification of minimum residual fixations in PET-F.D.G., considered as the residual disease in the non Hodgkin lymphomas. we report the case of a thirty four years old patient treated for diffuse at big B cells non Hodgkin lymphoma, in failure after the first line of treatment and with persistence of a hyper-metabolism in pre and post graft at the level of a para-cardiac residual mass. The post auto graft PET examination showed an important activation of the brown fat, able to question the origin of the residual para-cardiac hyper-metabolism in this dramatic situation, for a young patient and potentially still in therapy failure. In order to reduce the F.D.G. captation by the brown fat, it was proposed a new PET evaluation with propranolol administration (beta blocking) before the tracer injection. The intake of propranolol allowed to reduce in an important way, the F.D.G. captation by the brown fat, without modifying the residual hyper-metabolism. This result is going to lead to the realisation of a surgical biopsy. (N.C.)

  17. Long-term results with tracheoesophageal voice prosthesis: primary versus secondary TEP.

    Science.gov (United States)

    Boscolo-Rizzo, Paolo; Zanetti, Federica; Carpené, Silvia; Da Mosto, Maria Cristina

    2008-01-01

    The aim of this study was to evaluate the influence of timing of tracheoesophageal puncture (TEP)with indwelling voice prosthesis insertion regarding long-term success rate and postoperative complication. We conducted a Retrospective clinical study at tertiary academic center. There were 75 patients with primary TEP (80.6%) and 18 with secondary TEP (19.3%). Long-term success rate was 81.7%, with 80.0% in primary TEP and 88.9% in secondary TEP. No significant difference in Harrison-Robillard-Schultz Rating Scale success assessment were observed between patients with primary and secondary TEP (P = .596). The use of postoperative radiotherapy did not significantly influence the success rate. The age of patients who were older or younger than 60 years significantly influence the success rate in primary TEP (P = .012). The higher rate of complications in primary TEP was not statistically significant. These findings suggest that primary and secondary TEP are equally safe and effective procedures. Primary TEP should be preferred because of avoiding a second surgical intervention and allowing early voice restoration with a considerable psychological impact.

  18. Seasonal size spectra of transparent exopolymeric particles (TEP) in a coastal sea and comparison with those predicted using coagulation theory

    DEFF Research Database (Denmark)

    Mari, Xavier; Burd, A

    1998-01-01

    The abundance and size distribution of transparent exopolymeric particles (TEP) were monitored in the Kattegat (Denmark) during 1 yr. TEP number concentration ranged from 0.5 x 10(5) to 3.8 x 10(5) ml(-1) and the volume concentration between 3 and 310 ppm. TEP volume concentration peaked during...... the spring bloom and again during the summer period. The observed accumulation of TEP during summer is consistent with the recent observation that dissolved organic matter (DOM) concentration has a similar seasonal distribution and suggests that TEP are formed from DOM. The supposed mode of formation of TEP...... (coagulation of colloidal organic particles) was tested by comparing the observed TEP size spectra with those predicted by means of a coagulation model. The model used was a steady-state version of a particle coagulation model extended to include interactions between TEP and non-TEP particles. The spectra...

  19. Compositional Similarities and Differences between Transparent Exopolymer Particles (TEP) from two Marine Bacteria and two Marine Algae: Significance to Surface Biofouling

    KAUST Repository

    Li, Sheng

    2015-06-12

    Transparent-exopolymer-particles (TEP) have been recently identified as a significant contributor to surface biofouling, such as on reverse osmosis (RO) membranes. TEP research has mainly focused on algal TEP/TEP precursors while limited investigations have been conducted on those released by bacteria. In this study, TEP/TEP precursors derived from both algae and bacteria were isolated and then characterized to investigate their similarities and/or differences using various advanced analytical techniques, thus providing a better understanding of their potential effect on biofouling. Bacterial TEP/TEP precursors were isolated from two species of marine bacteria (Pseudidiomarina homiensis and Pseudoalteromonas atlantica) while algal TEP/TEP precursors were isolated from two marine algae species (Alexandrium tamarense and Chaetoceros affinis). Results indicated that both isolated bacterial and algal TEP/TEP precursors were associated with protein-like materials, and most TEP precursors were high-molecular-weight biopolymers. Furthermore all investigated algal and bacterial TEP/TEP precursors showed a lectin-like property, which can enable them to act as a chemical conditioning layer and to agglutinate bacteria. This property may enhance surface biofouling. However, both proton nuclear magnetic resonance (NMR) spectra and the nitrogen/carbon (N/C) ratios suggested that the algal TEP/TEP precursors contained much less protein content than the bacterial TEP/TEP precursors. This difference may influence their initial deposition and further development of surface biofouling.

  20. Diffuse bone marrow uptake in {sup 18}F-F.D.G.-PET in cancer patients: Interpretation and comparison with MRI results; Hypermetabolismes medullaires en TEP au {sup 18}F-FDG chez les patients atteints de cancer: signification et comparaison a l'IRM medullaire

    Energy Technology Data Exchange (ETDEWEB)

    Daragon, N.; Olivier, P.; Netter, F.; Journo, A.; Karcher, G.; Scigliano, S. [CHU de Nancy-Brabois, Service de Biophysique et de Medecine Nucleaire, 54 - Vandoeuvre (France); Bruot, O.; Laurent, V. [CHU de Nancy-Brabois, Service de Service de Radiologie, 54 - Vandoeuvre (France)

    2009-02-15

    Diffuse bone marrow uptake of {sup 18}F-F.D.G.-PET in cancer patients raises the problem of differential diagnosis between marrow involvement and stimulated marrow. In this study, we prospectively included, during a 1-year period, all cancer patients referred for initial staging showing an unexplained diffuse bone marrow uptake and explored consecutively by MRI. The abnormalities described on PET and the conclusion reached about disease status of bone marrow ('benign' or 'malignant') were compared with corresponding MRI results, as well as clinical and biological findings pertinent when bone marrow activity is studied, marrow status considered by referring clinicians, and follow-up data. During 1 year, 60 patients had diffuse bone marrow uptake on {sup 18}F-F.D.G.-PET, 26 underwent MRI examination and were finally included in the study. Results of PET and MRI were concordant in 24 cases (six 'malignant' and 18 'benign') and two cases were discordant, judged 'malignant' by MRI and 'benign' by PET. The outcome after confrontation of MRI and PET, was 'malignant' for one patient and 'benign' for the other one. The final results, was 'malignant' for seven patients and 'benign' for 19 patients and this final diagnosis was retained by referring clinicians. Among the 19 patients with diffuse bone marrow uptake considered as benign, seven patients had a pejorative evolution and four of them developed osteo-medullary metastases. In cancer patients, {sup 18}F-F.D.G.-PET identify bone marrow diffuse uptake which seems to correspond well to abnormalities assessed on MRI studies. Notably, heterogenous {sup 18}F-F.D.G. uptake and/or foci of increased uptake seems significant of marrow involvement. The limited population size and discordant published findings about bone marrow evaluation by {sup 18}F-F.D.G.-PET compared with MRI can not permit to ensure that these imaging modalities or one of these are sufficient to assess bone marrow status without performing bone marrow biopsy. Some patients with unexplained diffuse bone marrow uptake develop disease progression, such observations could be interestingly assessed by further studies. (authors)

  1. Contribution of positron computed tomography with {sup 18}F fluorodeoxyglucose (PET-F.D.G.) in the taking over the anal channel cancer; Apport de la tomographie par emission de positons au 18F fluorodeoxyglucose (TEP-FDG) dans la prise en charge du cancer du canal anal

    Energy Technology Data Exchange (ETDEWEB)

    Renaud, S.; Guillemard, S.; Eberle Pouzeratte, M.C.; Faurous, P.; Artus, J.C. [CRLC Val d' Aurelle, service de medecine nucleaire, Montpellier, (France); Lemanski, C. [CRLC Val d' Aurelle, service de radiotherapie, Montpellier, (France)

    2009-05-15

    The PET presents an interest in the management of the anal canal cancer, particularly in the ambiguous diagnosis situations where the metabolic information brought allow to influence the therapy choice in about the half of cases. (N.C.)

  2. Double localization of neuro lymphomatosis in an early relapse of non-Hodgkin lymphoma and ({sup 18}F)-F.D.G. PET-CT: Case report;Double localisation de neurolymphomatose d'une rechute prcoce d'un lymphome non hodgkinien en TEP-TDM au ({sup 18}F)-FDG: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Cazaentre, T.; Pascal-ortiz, D. [Hopital Saint-Jean, Service de medecine nucleaire, 66 - Perpignan (France); Sanhes, L.; Vallantin, X. [Hopital Saint-Jean, Service d' hematologie, 66 - Perpignan (France); Cassarini, J.F. [Hopital Saint-Jean, Service de neurologie, 66 - Perpignan (France)

    2010-06-15

    In a patient suffering from left lower limb pain and chin anesthesia, fused PET-CT imaging showed an ({sup 18}F)-F.D.G. uptake along the left sciatic nerve and the mandibular branch of the left trigeminal nerve corresponding to neuro lymphomatosis due to an early relapse of a B-cell non-Hodgkin's lymphoma. (authors)

  3. Comparison of prognosis values of pre therapy PET-T.D.M. with {sup 18}F-F.D.G. and MRI in the uterus cervix cancer; Comparaison des valeurs pronostiques des TEP-TDM au 18F-FDG et IRM pretherapeutiques dans le cancer du col de l'uterus

    Energy Technology Data Exchange (ETDEWEB)

    Chastan, M.; Baron, M.; Diologent, B.; Edet Sanson, A.; Guernou, M.; Vera, P.; Hitzel, A. [Centre Henri-Becquerel, Rouen, (France); Manrique, A. [GIP Cyceron, Caen, (France)

    2009-05-15

    The objective is to compare the prognosis value of the pre-therapy pelvis PET--T.D.M. with {sup 18}F-F.D.G. and MRI in the uterine cervix carcinoma. The conclusions: in the uterine cervix carcinomas, the existence of a pelvis ganglion injury on the pre-therapy PET-T.D.M. with {sup 18}F-F.D.G. is a prognosis factor independent of recurrence and death at one year. The MRI does not bring any additional information relative to the prognosis of the disease. (N.C.)

  4. Comparative evaluation of osseous injuries detection efficiency of osseous sarcomas and soft tissues by osseous scintigraphy and the PET with {sup 18}F-F.D.G; Evaluation comparative de l'efficacite de detection des lesions osseuses des sarcomes osseux et des tissus mous par la scintigraphie osseuse et la TEP au {sup 18}F-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Deshayes, E. [Hopital Edouard-Herriot, Service de medecine nucleaire, 69 - Lyon (France); Mognetti, T.; Cimarelli, S. [Centre Leon-Berard, service de medecine nucleaire, 69 - Lyon (France); Ricard, F.; Giammarile, F. [Centre hospitalier Lyon-Sud, service de medecine nucleaire, 69 (France)

    2010-07-01

    The purpose of this retrospective study is to compare the diagnostic efficiency of the bone scintigraphy compared to the PET with {sup 18}F-F.D.G. in the detection of primitive or secondary bone injuries of soft tissues sarcomas or bone sarcomas. In view of our results and analysis of literature, performing a bone scan of Ewing sarcoma and soft tissue sarcomas do not seem useful. It retains an interest in the case of osteosarcoma. (N.C.)

  5. The morpho-PET with {sup 18}F-F.D.G. improves the definition of the target volume for the radiotherapy of child Hodgkin disease; Le morpho-TEP au 18F-FDG ameliore la definition du volume cible pour la radiotherapie des maladies de Hodgkin de l'enfant

    Energy Technology Data Exchange (ETDEWEB)

    Metwally, H.; Courbon, F.; David, I.; Blouet, A.; Izar, F.; Rives, M.; Filleron, T.; Vial, J.; Laprie, A. [Institut Claudius-Regaud, Toulouse, (France); Robert, A. [CHU Toulouse, (France)

    2009-05-15

    The objective is to study the impact of PET-T.D.M. images re-timing before chemotherapy with these ones of dosimetric scanner ( post chemotherapy) on the target volume determination and their inter observers variability among children receiving a closing radiotherapy for a Hodgkin disease. Conclusions: the inter observers variability for the clinical target volume (C.T.V.) definition is significantly reduced by the re-timing of initial PET-T.D.M. images on the ballistic scanner. This study illustrates the interest of the multidisciplinary cooperation between nuclear doctor and radiotherapist for the radiotherapy optimization. (N.C.)

  6. Interest of PET/CT with {sup 18}F-F.D.G. in the management of a multifocal tuberculosis with multi-resistant bacillus; Interet de la TEP-TDM au {sup 18}F-FDG dans la prise en charge d'une tuberculose multifocale a bacilles multiresistants

    Energy Technology Data Exchange (ETDEWEB)

    Ben Sellem, D.; Hubele, F.; Hassler, S.; Goetz, C.; Constantinesco, A. [hopital Hautepierre, Service de medecine nucleaire, 67 - Strasbourg (France)

    2010-07-01

    Purpose: Assess the interest of PET / CT with {sup 18}F-F.D.G. in the management of multifocal tuberculosis with resistant bacilli. Conclusion: Through this case, PET-CT with {sup 18}F-F.D.G. seems to be well suited in evaluating the therapeutic efficiency of bacilli resistant multifocal tuberculosis. (N.C.)

  7. Impact of the PET/CT with {sup 18}F-F.D.G. in the management of patients suffering of differentiated thyroid cancer; Impact de la TEP/TDM au {sup 18}F-FDG dans la prise en charge des patients atteints de cancer thyroidien differencie

    Energy Technology Data Exchange (ETDEWEB)

    Eberle-Pouzeratte, M.C.; Guillemard, S.; Thezenas, S.; Espitalier-Riviere, C.; Faurous, P.; Lamy, P.J.; Artus, J.C. [CRLC Val d' Aurelle P. Lamarque, 34 - Montpellier (France); Sibille, L.; Rossi, M. [CHU Lapeyronie, 34 - Montpellier (France)

    2010-07-01

    Purpose: The differentiated thyroid cancers have a lower avidity to {sup 18}F-F.D.G. making their exploration by this technique less sensitive. The impact of PET/CT with {sup 18}F-F.D.G. on the management of patients suspected of differentiated thyroid cancer recurrence was analyzed prospectively. Conclusions: Our study confirms the interest of the {sup 18}F-F.D.G. PET/CT for patients suffering of differentiated thyroid cancer and suspected of recurrence /residual disease. This hybrid imaging examination can be proposed systematically in case of isolated elevation of basal T{sub g} >1.2 ng/m L during the follow-up, in order to guide any further surgery. (N.C.)

  8. Comparison of target volumes in radiotherapy defined on scanner and on PET-T.D.M. with {sup 18}F-F.D.G. in the frame of head and neck cancers; Comparaison des volumes cibles en radiotherapie definis sur scanner et sur TEP-TDM au 18F FDG dans le cadre des cancers de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Henriques De Figueiredo, B.; Barret, O.; Allard, M.; Fernandez, P. [Service de medecine nucleaire, CHU de Pellegrin, Bordeaux, (France); Demeaux, H.; Maire, J.P.; Lagarde, P. [service de radiotherapie, hopital Saint-Andre, Bordeaux, (France); Kantor, G.; Richau, P. [departement de radiotherapie, institut Bergonie, Bordeaux, (France); De Mones Del Pujol, E. [service d' ORL, hopital Pellegrin, Bordeaux, (France)

    2009-05-15

    The objective is to study in a prospective way, in the frame of head and neck cancers, the impact of the positron computed tomography with {sup 18}F fluorodeoxyglucose (PET-F.D.G.) on the limitation of target volumes in radiotherapy. In conclusions, the gross tumor volume (G.T.V.) defined on PET is smaller than this one defined on scanner, that could be interesting in radiotherapy, in the perspective of a dose escalation. In addition, areas of discordance exist between the clinical target volumes (C.T.V.70 and C.T.V.50) defined on PET and on scanner. These discordances, synonyms of under or over estimation of target volumes, could have important clinical consequences in term of local control and toxicity. (N.C.)

  9. Interest of the PET with {sup 18}F-F.D.G. in the early evaluation of the therapy response to the Hodgkin lymphoma; Interet de la TEP au 18F-FDG dans l'evaluation precoce de la reponse therapeutique du lymphome de Hodgkin

    Energy Technology Data Exchange (ETDEWEB)

    Edera, V.; Boursot, C.; Baulieu, F.; Baulieu, J.L. [Service de medecine nucleaire, CHU de Tours, (France); Senecal, D.; Colombat, P. [service d' hematologie et therapie cellulaire, CHU de Tours, (France)

    2009-05-15

    This retrospective study included 38 consecutive patients having received of an initial and reevaluation PET with {sup 18}F-F.D.G. after two treatments of chemotherapy with a backward step of follow-up of, at least, eighteen months. In conclusion, the evaluation of the early therapy response by the PET with {sup 18}F-F.D.G. to two treatments is complementary of the Goelams prognosis score to evaluate the final prognosis and manage the treatment. Prospective data must confirm these results. (N.C.)

  10. Characterization by SPECT imaging, micro-PET with {sup 18}F-F.D.G. and micro scanner of an orthotopic osteosarcoma murine model; Caracterisation par imagerie TEMP, micro-TEP au {sup 18}F-FDG et microscanner d'un modele murin d'osteosarcome orthotopique

    Energy Technology Data Exchange (ETDEWEB)

    Miot-Noirault, E.; Moins, N.; Chezal, J.M. [EA4231, UMR 990, Inserm, 63 - Clermont-Ferrand (France); Gouin, F.; Heymann, D.; Redini, F. [EA3822, UMR 957, 44 - Nantes (France)

    2010-07-01

    This study had for purpose the characterization of the murine model of POS-1 osteolytic osteosarcoma implanted in orthotopic situation, by SPECT imaging, micro-PET, micro scanner, clinical and histological study. Conclusions: these results show all the interest of multimodal small animal imaging as quantitative method of evaluation in vivo of the osteosarcoma tumor progression and bone rebuilding associated to the osteolytic evolution. The assessment in vivo of this pathology should allow to improve the knowledge of interactions between tumor cells and bone environment, preclinical evaluation in vivo of new therapy strategies targeting both tumor development and bone resorption. (N.C.)

  11. Interest of PET/CT with {sup 18}F-F.D.G. in the diagnosis of endocarditis on pacemaker or defibrillator to be implanted; Interet de la TEP-TDM au 18FDG dans le diagnostic d'endocardite sur pacemaker ou defibrillateur implantable

    Energy Technology Data Exchange (ETDEWEB)

    Bensimhon, L.; Hugonnet, F.; Maunoury, C.; Faraggi, M. [Hopital europeen Georges-Pompidou, Service de medecine nucleaire, 75 - Paris (France); Lavergne, T.; Leheuzey, J.Y. [Hopital europeen Georges-Pompidou, Service de cardiologie, 75 - Paris (France); Mainardi, J.L. [Hopital europeen Georges-Pompidou, Service de microbiologie, 75 - Paris (France); Latremouille, C. [Hopital europeen Georges-Pompidou, Service de chirurgie cardiovasculaire, 75 - Paris (France)

    2010-07-01

    Purpose: Infection of pacemaker device or implantable defibrillators are rare (<5%) but serious and sometimes difficult, we evaluated the interest of PET / CT with {sup 18}F-F.D.G. in the diagnosis. conclusion: PET can be useful to diagnose infection on pacemaker and implantable defibrillators. A prolonged antibiotic therapy may cause false negatives. In our series, the management could have been altered by the examination in 6 out of 21. (N.C.)

  12. Performances evaluation of the PET/CT with {sup 18}F-F.D.G. in the diagnosis of peritoneal carcinosis with a colorectal origin; Evaluation des performances de la TEP-TDM au {sup 18}F-FDG dans le diagnostic de la carcinose peritoneale d'origine colorectale

    Energy Technology Data Exchange (ETDEWEB)

    Bullier, E. [CHU de Bordeaux, Service de medecine nucleaire, hopital de Haut-Leveque, 33 (France); Bonichon, F.; Cazeau, A.L. [Institut Bergonie CRLCC d' Aquitaine, service de medecine nucleaire, 33 - Bordeaux (France); Descat, E. [Institut Bergonie CRLCC d' Aquitaine, service de radiologie, 33 - Bordeaux (France); Evrard, S. [Institut Bergonie CRLCC d' Aquitaine, Dept. de Chirurgie, 33 - Bordeaux (France); Picat, Q. [Bergonie CRLCC d' Aquitaine, Dept. de biostatistique, 33 - Bordeaux (France)

    2010-07-01

    Purpose: the purpose of this study is to evaluate the performances and the inter-observers concordances of the PET-CT with {sup 18}F-F.D.G. in the detection of the peritoneal carcinosis in colorectal cancers, with evaluation of peritoneal extension, description of semiotics signs allowing to raise the diagnosis and confrontation of this performance to that of CT. Conclusions: The PET-CT with {sup 18}F-F.D.G. seems to be a powerful and reproducible examination for the peritoneal carcinosis diagnosis, with a methodology of research oriented proofreading of peritoneal carcinosis. Studies are to make to evaluate prospectively the extension of peritoneal carcinosis. (N.C.)

  13. Interest of the PET-T.D.M. with {sup 18}F-F.D.G. in the management of a tuberculosis; Interet de la TEP-TDM au 18F-FDG dans la prise en charge d'une tuberculose

    Energy Technology Data Exchange (ETDEWEB)

    Ben Sellem, D.; Hubele, F.; Imperiale, A.; Constantinesco, A. [Service de medecine nucleaire, hopital Hautepierre, Strasbourg, (France); Lefebvre, N.; Hansmann, Y. [service de maladies infectieuses et tropicales, NHC, Strasbourg, (France)

    2009-05-15

    The objective was to evaluate the interest of the PET-T.D.M. with {sup 18}F-F.D.G. in the diagnosis and the coverage of an abdomen ganglion tuberculosis. Conclusions: Through the presented case, the PET-T.D.M. with {sup 18}F-F.D.G. seems to be well adapted to determine the lesion cartography of the seronegative tuberculosis, the targeting of biopsies and the efficiency of the therapy evaluation. (N.C.)

  14. Interest of the scintigraphy PET {sup 18}F-F.D.G. for the evaluation of the early response to the treatment by adalimumab in the rheumatoid poly-arthritis; Interet de la scintigraphie TEP {sup 18}F-FDG pour l'evaluation de la reponse precoce au traitement par adalimumab dans la polyarthrite rhumatoide

    Energy Technology Data Exchange (ETDEWEB)

    Eder, V.; Courtehoux, M.; Baulieu, J.L. [Service de medecine nucleaire, CHU de Tours, (France); Mulleman, D.; Paintaud, G.; Goupille, P.; Ternant, D. [Service de rhumatologie, CHU de Tours, (France)

    2009-05-15

    The aim of this study was to evaluate the interest of the follow-up of the {sup 18}F-F.D.G. uptake during the treatment of the rheumatoid poly-arthritis by 40 mg during 2 weeks of adalimumab (an anti-TNF-alpha human monoclonal antibody), comparatively to the usual clinical and biological follow-up. The PET with {sup 18}F-F.D.G. is a promising technique to enlighten early the anti inflammatory pharmaco-dynamic effect of the adalimumab in the rheumatoid poly-arthritis. (N.C.)

  15. Extra gonadal non-seminomatous germ cell tumour and PET-T.D.M. with {sup 18}F-F.D.G.: about one case of primitive retroperitoneal choriocarcinoma; Tumeurs germinales non seminomateuses extragonadiques et TEP-TDM au F-18 FDG: a propos d'un cas de choriocarcinome retroperitoneal primitif

    Energy Technology Data Exchange (ETDEWEB)

    Cimarelli, S.; Deshayes, E.; Mognetti, T.; Desuzinges, C. [Service de medecine nucleaire, centre Leon-Berard, Lyon, (France); Biron, P. [departement d' oncologie, centre Leon-Berard, Lyon, (France); Rivoire, M. [departement de chirurgie, centre Leon-Berard, Lyon, (France); Giammarile, F. [service de medecine nucleaire, hopital Lyon-Sud, (France)

    2009-05-15

    The non-seminomatous germinal tumors represent 60% of the germinal tumors, the most frequent cancer for young men.The positron computed tomography/computed tomography (PET/T.D.M.) with {sup 18}F fluorodeoxyglucose seems full of promises for the initial evaluation and the early evaluation of chemotherapy. for this type of tumor. In 1 to 5% of cases these tumors are extra gonadal. We present the case of a twenty three years old man with a retroperitoneal primitive choriocarcinoma with numerous metastases for whom the metabolic imaging was useful. We discuss the interest of this examination in this rare pathology. For the extra gonadal non-seminomatous germinal tumors the PET-F.D.G. seems bring information useful for the determination of the viable character of a post-chemotherapy residual mass, especially when the anatomical imaging show results discordant with the clinico biological data. (N.C.)

  16. Bilateral total extraperitoneal inguinal hernia repair (TEP) has outcomes similar to those for unilateral TEP: population-based analysis of prospective data of 6,505 patients.

    Science.gov (United States)

    Gass, Markus; Rosella, Laura; Banz, Vanessa; Candinas, Daniel; Güller, Ulrich

    2012-05-01

    Whether bilateral total extraperitoneal (TEP) inguinal hernia repair is associated with worse outcomes than unilateral TEP continues to be a matter of debate. This study aimed to compare different outcomes of large cohorts of patients undergoing bilateral versus unilateral TEP. Based on prospective data of the Swiss Association of Laparoscopic and Thoracoscopic Surgery (SALTS), all patients undergoing elective unilateral or bilateral TEP from 1995 to 2006 were included in the study. The outcomes compared included conversion rates; intraoperative, surgical, and general postoperative complications; duration of operation; and length of hospital stay (LOS). Unadjusted and risk-adjusted multivariable analyses were performed. Data for 6,505 patients undergoing unilateral (n = 3,457) and bilateral (n = 3,048) TEP were prospectively collected. The average age and the American Society of Anesthesiologists (ASA) score were similar in the two groups. The patients undergoing bilateral TEP repair had a slightly increased rate of intraoperative complications (bilateral, 3.1% vs. unilateral, 1.9%) and surgical postoperative complications (bilateral, 3.2% vs. unilateral, 2.3%). The operation time was longer for bilateral TEP repair (86 vs. 67 min). No significant differences in postoperative LOS, general postoperative complications, or conversion rates were found. This is the first population-based analysis in the literature to compare different outcomes in a prospective cohort of more than 6,500 patients undergoing bilateral versus unilateral TEP. Although the rates for intraoperative and surgical postoperative complications were slightly higher for the patients undergoing bilateral TEP repair, the absolute differences were small and of minor clinical relevance. Bilateral TEP repair is associated with a minimal increase in operating time and similar LOS, general postoperative complications, and conversion rates. Therefore, for patients with bilateral inguinal hernia, a

  17. Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo

    OpenAIRE

    Liu, Yie; Snow, Bryan E.; Hande, M. Prakash; Baerlocher, Gabriela; Kickhoefer, Valerie A.; Yeung, David; Wakeham, Andrew; Itie, Annick; Siderovski, David P.; Lansdorp, Peter M.; Robinson, Murray O.; Harrington, Lea

    2000-01-01

    TEP1 is a mammalian telomerase-associated protein with similarity to the Tetrahymena telomerase protein p80. Like p80, TEP1 is associated with telomerase activity and the telomerase reverse transcriptase, and it specifically interacts with the telomerase RNA. To determine the role of mTep1 in telomerase function in vivo, we generated mouse embryonic stem (ES) cells and mice lacking mTep1. The mTep1-deficient (mTep1−/−) mice were viable and were bred for seven successive generations with no ob...

  18. Totally extraperitoneal (TEP) endoscopic hernia repair in elderly patients.

    Science.gov (United States)

    Voorbrood, C E H; Burgmans, J P J; Clevers, G J; Davids, P H P; Verleisdonk, E J M M; van Dalen, T

    2015-12-01

    Inguinal hernias are common in elderly males. We addressed outcome following totally extraperitoneal (TEP) hernia repair in patients older than 70 years. We prospectively collected data of patients >70 years with a unilateral or bilateral inguinal hernia operated in our hospital between January 2005 and January 2010 using the TEP technique. A total of 429 patients underwent TEP hernia repair under general anaesthesia, mostly men (n = 405; 94.4%). Median age was 74 years (range 70-89). The mean pre-operative pain score was 3.7 (SD ± 2.5). Ninety-four percent of patients had an ASA score of 1 or 2. Three hundred thirty-six patients underwent a unilateral repair (78%). The conversion rate to an anterior procedure was 0.7 % (n = 3). In 8 patients (1.9%), intra-operative complications occurred, and the postoperative course was complicated in 3 patients (0.7 %). Severe complications attributable to the endoscopic approach occurred in 6 patients (1.4%): a bladder injury (n = 5) and a trocar-induced bowel perforation (n = 1). The mean postoperative pain score after 6 weeks was 1.6 (SD ± 1.2). Patients were able to resume their daily activities after a median of 7 days (range 1-42). Totally, extraperitoneal endoscopic inguinal hernia repair in elderly patients is associated with low overall complication rates and a fast recovery. In a small proportion of patients, severe complications occur attributable to the endoscopic approach.

  19. Is there an end of the "learning curve" of endoscopic totally extraperitoneal (TEP) hernia repair?

    Science.gov (United States)

    Schouten, N; Simmermacher, R K J; van Dalen, T; Smakman, N; Clevers, G J; Davids, P H P; Verleisdonk, E J M M; Burgmans, J P J

    2013-03-01

    An important challenge of totally extraperitoneal (TEP) hernia repair is the learning curve. The European guidelines suggest that the learning curve ranges between 50 and 100 procedures, with the first 30-50 being critical. Others suggest that optimal outcomes are achieved after 200 or more TEP procedures. All TEP repairs performed between 2005 and 2009 were included in this study. The effect of (surgeon) expertise on perioperative complications, conversion to open anterior repair, and operative time was assessed to evaluate the extent of the learning curve of TEP repair. Intraoperative complications occurred in TEP, 19 patients (0.55 %) had a recurrence. During the study period, at the end of which all four surgeons had treated 900-1,000 patients, intraoperative complications and recurrences did not decline. On the other hand, the median operative time decreased from 30 to 20 min (p TEP. The largest decrease in the conversion rate was seen after at least 250 TEP procedures; the postoperative complication rate and operative time showed a linear and significant decline throughout the study period. A more or less "steady state" was observed after approximately 450 procedures per surgeon. Even after more than 400 individually performed TEP procedures, there is progress in reducing the conversion rate, the incidence of short-term postoperative complications, and operative time, indicating a rather long learning curve.

  20. Chronic pain after TEP inguinal hernia repair, does MRI reveal a cause?

    NARCIS (Netherlands)

    Burgmans, J. P J; Voorbrood, C. E H; Van Dalen, T.; Boxhoorn, R. N.; Clevers, G. J.; Sanders, F. B M; Naafs, D. B J; Simmermacher, R. K J|info:eu-repo/dai/nl/119478692

    2016-01-01

    Purpose: Persistent pain is a known side effect after TEP inguinal repair disabling 2–5 % of patients. A standardized diagnostic work-up so far is not available. MRI is a diagnostic tool in the work-up of inguinal hernias. In the present study the yield of MRI in evaluating chronic pain after TEP

  1. Evaluation of potential particulate/colloidal TEP foulants on a pilot scale SWRO desalination study

    KAUST Repository

    Li, Sheng

    2016-01-21

    This pilot study investigated the variation of potential foulants and different fractions of transparent exopolymer particles (TEP), along the treatment scheme under different conditions. The objectives are to provide a comprehensive understanding on which fraction of TEP is more problematic in seawater reverse osmosis (SWRO) fouling, and which pretreatment can better reduce the concentration of TEP. Results showed that TEP deposited on the RO membranes, and the extent of RO fouling increased with the increase of TEP concentration in RO feed water. More TEP was produced in water after chlorination, probably because of the breakdown of bacterial cells and thus the release of internal exopolymers. Moreover, the cartridge filters could behave as an incubator for the regrowth of bacteria deactivated by chlorination and a spot for potential foulant (bacterial TEP) production, and thus enhance the RO membranes fouling. The presence of residual iron and addition of phosphate based antiscalant may also contribute to the higher biofouling of RO membranes. This pilot study provided an opportunity to identify the TEP related issues under different operational conditions in RO desalination of Red Sea water.

  2. Transparent exopolymer particles (TEP) and their potential effect on membrane biofouling.

    Science.gov (United States)

    Meng, Shujuan; Rzechowicz, Miles; Winters, Harvey; Fane, Anthony Gordon; Liu, Yu

    2013-07-01

    Transparent exopolymer particles (TEP) have been described as a class of particulate acidic polysaccharides, which are large, transparent organic particles, and commonly found in seawater, surface water, and wastewater. Due to their unique physicochemical characteristics, more and more attention has recently been given to the effects of TEP on membrane fouling. In this review, the characteristics and determination methods of TEP as well as its potential effect on membrane biofouling are discussed. It appears that the analytical methods for TEP available in the literature are still debatable, and there is room for further improvement. Nevertheless, evidence suggests that TEP might be involved in the development of membrane fouling, especially at the early stage of biofilm development on membranes.

  3. Improved method for measuring transparent exopolymer particles (TEP) and their precursors in fresh and saline water.

    Science.gov (United States)

    Villacorte, Loreen O; Ekowati, Yuli; Calix-Ponce, Helga N; Schippers, Jan C; Amy, Gary L; Kennedy, Maria D

    2015-03-01

    Transparent exopolymer particles (TEP) and their precursors produced by phyto-/bacterio-planktons in fresh and marine aquatic environments are increasingly considered as a major contributor to organic/particulate and biological fouling in micro-/ultra-filtration and reverse osmosis membrane (RO) systems. However, currently established methods which are based on Alcian blue (AB) staining and spectrophotometric techniques do not measure TEP-precursors and have the tendency to overestimate concentration in brackish/saline water samples due to interference of salinity on AB staining. Here we propose a new semi-quantitative method which allows measurement of both TEP and their colloidal precursors without the interference of salinity. TEP and their precursors are first retained on 10 kDa membrane, rinsed with ultra-pure water, and re-suspended in ultra-pure water by sonication and stained with AB, followed by exclusion of TEP-AB precipitates by filtration and absorbance measurement of residual AB. The concentration is then determined based on the reduction of AB absorbance due to reaction with acidic polysaccharides, blank correction and calibration with Xanthan gum standard. The extraction procedure allows concentration of TEP and their pre-cursors which makes it possible to analyse samples with a wide range of concentrations (down to TEP themselves. In the RO plant, complete TEP removal was observed over the pre-treatment processes (coagulation-sedimentation-filtration and ultrafiltration) but the TEP precursors were not completely removed, emphasising the importance of measuring this colloidal component to better understand the role of TEP and acidic polysaccharides in RO membrane fouling. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Improved method for measuring transparent exopolymer particles (TEP) and their precursors infresh and saline water

    KAUST Repository

    Villacorte, Loreen O.

    2015-03-01

    Transparent exopolymer particles (TEP) and their precursors produced by phyto-/bacterio-planktons in fresh and marine aquatic environments are increasingly considered as a major contributor to organic/particulate and biological fouling in micro-/ultra-filtration and reverse osmosis membrane (RO) systems. However, currently established methods which are based on Alcian blue (AB) staining and spectrophotometric techniques do not measure TEP-precursors and have the tendency to overestimate concentration in brackish/saline water samples due to interference of salinity on AB staining. Here we propose a new semi-quantitative method which allows measurement of both TEP and their colloidal precursors without the interference of salinity. TEP and their precursors are first retained on 10kDa membrane, rinsed with ultra-pure water, and re-suspended in ultra-pure water by sonication and stained with AB, followed by exclusion of TEP-AB precipitates by filtration and absorbance measurement of residual AB. The concentration is then determined based on the reduction of AB absorbance due to reaction with acidic polysaccharides, blank correction and calibration with Xanthan gum standard. The extraction procedure allows concentration of TEP and their pre-cursors which makes it possible to analyse samples with a wide range of concentrations (down to <0.1mg Xeq/L). This was demonstrated through application of the method for monitoring these compounds in algal cultures and a full-scale RO plant. The monitoring also revealed that concentrations of the colloidal precursors were substantially higher than the concentration of TEP themselves. In the RO plant, complete TEP removal was observed over the pre-treatment processes (coagulation-sedimentation-filtration and ultrafiltration) but the TEP precursors were not completely removed, emphasising the importance of measuring this colloidal component to better understand the role of TEP and acidic polysaccharides in RO membrane fouling.

  5. Distribution of TEP in the euphotic and upper mesopelagic zones of the southern Iberian coasts

    Science.gov (United States)

    Prieto, L.; Navarro, G.; Cózar, A.; Echevarría, F.; García, C. M.

    2006-06-01

    The spatial and temporal distributions of transparent exopolymer particles (TEP) were studied for the Gulf of Cádiz, by analyzing its abundance in the euphotic and upper mesopelagic zones. Both layers of the water column should reflect a distinct pattern in TEP distribution, as production of TEP is mainly linked to phytoplankton activity, which is sited in the euphotic zone, while losses of TEP due to aggregation-sinking and degradation occur from the surface to further below in the water column. Concentration of TEP in the euphotic zone reflected the varied oceanographic characteristics of the studied region. It was higher in coastal upwellings, fronts and such areas of topographic forcing, suggesting that TEP were being produced by active growing phytoplankters. A comparison with a well-known ecosystem, the coastal upwelling in the northwestern Alboran Sea, showed that the TEP:Chl a ratio at stations with clear eutrophic characteristics was several orders of magnitude lower than in the area southwest of the anticyclonic current of the Gulf. This ratio in the highly dynamic system of the Strait of Gibraltar seems to have a much clearer relation with the stage of a bloom and, at a basin scale, to the trophic condition of the ecosystem than TEP concentrations alone. Throughout the area studied in the Gulf of Cádiz, the role of TEP for aggregation processes was analyzed based on two aggregation models. Both approximations pointed to the importance of TEP in the export of matter from the euphotic zone to deeper waters in the Gulf of Cádiz.

  6. Non FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Nanni, C., E-mail: cristina.nanni@aosp.bo.i [Nuclear Medicine Unit, Policlinico S.Orsola, University of Bologna, Bologna (Italy); Fantini, L.; Nicolini, S.; Fanti, S. [Nuclear Medicine Unit, Policlinico S.Orsola, University of Bologna, Bologna (Italy)

    2010-07-15

    2- [{sup 18}F]-fluoro-2-deoxy-D-glucose (FDG) is the radiopharmaceutical most frequently used for clinical positron emission tomography (PET). However, FDG cannot be used for many oncological, cardiological, or neurological conditions, either because the abnormal tissue does not concentrate it, or because the tissues under investigation demonstrate high physiological glucose uptake. Consequently, alternative PET tracers have been produced and introduced into clinical practice. The most important compounds in routine practice are {sup 11}C-choline and {sup 18}F-choline, mainly for the evaluation of prostate cancer; {sup 1}C-methionine for brain tumours; {sup 118}F-DOPA ({sup 18}F- deoxiphenilalanine) for neuroendocrine tumours and movement disorders; {sup 68}Ga-DOTANOC (tetraazacyclododecanetetraacetic acid-[1-Nal3]-octreotide) and other somatostatin analogues for neuroendocrine tumours; 11C-acetate for prostate cancer and hepatic masses and 18F-FLT (3'-deoxy-3'-fluorothymidine) for a number of malignant tumours. Another impetus for the development of new tracers is to enable the investigation of biological processes in tumours other than glucose metabolism. This is especially important in the field of response assessment, where there are new agents that are targeted more specifically at angiogenesis, hypoxia, apoptosis and other processes.

  7. FDG PET imaging dementia

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Byeong Cheol [Kyungpook National University Medical School and Kyungpook National University Hospital, Daegu (Korea, Republic of)

    2007-04-15

    Dementia is a major burden for many countries including South Korea, where life expectancy is continuously growing and the proportion of aged people is rapidly growing. Neurodegenerative disorders, such as, Alzheimer disease, dementia with Lewy bodies, frontotemporal dementia. Parkinson disease, progressive supranuclear palsy, corticobasal degeneration, Huntington disease, can cause dementia, and cerebrovascular disease also can cause dementia. Depression or hypothyroidism also can cause cognitive deficits, but they are reversible by management of underlying cause unlike the forementioned dementias. Therefore these are called pseudodementia. We are entering an era of dementia care that will be based upon the identification of potentially modifiable risk factors and early disease markers, and the application of new drugs postpone progression of dementias or target specific proteins that cause dementia. Efficient pharmacologic treatment of dementia needs not only to distinguish underlying causes of dementia but also to be installed as soon as possible. Therefore, differential diagnosis and early diagnosis of dementia are utmost importance. F-18 FDG PET is useful for clarifying dementing diseases and is also useful for early detection of the disease. Purpose of this article is to review the current value of FDG PET for dementing diseases including differential diagnosis of dementia and prediction of evolving dementia.

  8. Laparoscopic treatment of Spiegel hernia by total extraperitoneal (TEP) approach.

    Science.gov (United States)

    Filip, S; Dragomirescu, C; Copăescu, C

    2014-01-01

    Spiegelian hernia is a rare type of ventral abdominal hernia. Surgical treatment is recommended due to the high risk of complications. Laparoscopic treatment is preferred to open repair, by means of intraperitoneal or extraperitoneal mesh placement, either by transperitoneal(TAPP) or by total extraperitoneal (TEP) approach. Total extraperitoneal approach is rarely reported in the literature. To evaluate the results of laparoscopic repair of Spiegelhernia by total extraperitoneal approach. We prospectively studied the patients operated on for Spiegel hernia between October 2009 and March 2013 by laparoscopic TEP approach at Ponderas Hospital. Data regarding symptoms, sex, preoperative work-up,surgical technique, hospital stay and outcome of the procedure were analysed. Follow-up of the patients was achieved at 1week, 1 month, 6 months and yearly postoperatively and patients were evaluated for recurrence, chronic pain, mesh infection, time to reinsertion to normal activities and overall patient satisfaction score. We have treated 4 patients with Spiegel hernia by laparoscopic TEP repair, with mean age 55.25 years (range 50-64), sex ratio 1 (2 2); all patients were symptomatic, all cases had left sided hernias, the surgical intervention was elective in all cases. Mean hospital stay was 1.5 days (range1- 2 days). There was only one postoperative complication ina patient with asymptomatic seroma, with remission in 1 month. There were no recurrences, no mesh infection, no chronic pain or other morbidity at a mean follow-up of 25 months (range 12-53 months). The overall satisfaction score was maximal (5) in all cases. Spiegelian hernias are rare but surgery is mandatory because of the risk of complications like incarceration and strangulation. In the presented experience, laparoscopic total extraperitoneal approach proved to be an efficient technique,reproducible, with excellent results for Spiegel hernia treated electively. Celsius.

  9. The skewed N:P stoichiometry resulting from anthropogenic drivers regulate production of transparent exopolymer particles (TEP) in Ganga River.

    Science.gov (United States)

    Pandey, Usha; Pandey, Jitendra

    2015-01-01

    Transparent exopolymer particles (TEP), generated from excretion products of microalgae, trigger flocculation of diatoms and sinking of organic matter. Investigations along 797 km stretch of Ganga River indicated that TEP declined with increasing N:P stoichiometric ratio downstream. The TEP showed positive relationship with chlorophyll a (R(2) = 0.9661; p TEP in Ganga River showed that the shifting N:P stoichiometric ratios resulting from anthropogenic release may alter TEP production and, by implication, ecosystem functioning including carbon sequestration in the river.

  10. Synthesis and characterization of TEP-EDTA-regulated bioactive hydroxyapatite

    Science.gov (United States)

    Haders, Daniel Joseph, II

    Hydroxyapatite (HA), Ca10(PO4)6(OH) 2, the stoichiometric equivalent of the ceramic phase of bone, is the preferred material for hard tissue replacement due to its bioactivity. However, bioinert metals are utilized in load-bearing orthopedic applications due to the poor mechanical properties of HA. Consequently, attention has been given to HA coatings for metallic orthopedic implants to take advantage of the bioactivity of HA and the mechanical properties of metals. Commercially, the plasma spray process (PS-HA) is the method most often used to deposit HA films on metallic implants. Since its introduction in the 1980's, however, concerns have been raised about the consequences of PS-HA's low crystallinity, lack of phase purity, lack of film-substrate chemical adhesion, passivation properties, and difficulty in coating complex geometries. Thus, there is a need to develop inexpensive reproducible next-generation HA film deposition techniques, which deposit high crystallinity, phase pure, adhesive, passivating, conformal HA films on clinical metallic substrates. The aim of this dissertation was to intelligently synthesize and characterize the material and biological properties of HA films on metallic substrates synthesized by hydrothermal crystallization, using thermodynamic phase diagrams as the starting point. In three overlapping interdisciplinary studies the potential of using ethylenediamine-tetraacetic acid/triethyl phosphate (EDTA/TEP) doubly regulated hydrothermal crystallization to deposit HA films, the TEP-regulated, time-and-temperature-dependent process by which films were deposited, and the bioactivity of crystallographically engineered films were investigated. Films were crystallized in a 0.232 molal Ca(NO3)2-0.232 molal EDTA-0.187 molal TEP-1.852 molal KOH-H2O chemical system at 200°C. Thermodynamic phase diagrams demonstrated that the chosen conditions were expected to produce Ca-P phase pure HA, which was experimentally confirmed. EDTA regulation of

  11. Totally extraperitoneal approach (TEP) for scrotal cystocele - a video vignette.

    Science.gov (United States)

    Capitano, Sante

    2017-10-20

    Scrotal cystocele is a large sliding inguinal hernia involving the urinary bladder. This situation is very rare, occurring in fewer than 1% of all inguinal hernias and are diagnosed preoperatively in less than 7% of cases. Depending on the relationship with the peritoneum, we can classify them in: paraperitoneal, intraperitoneal and extraperitoneal type. There are currently very few cases of laparoscopic repair of bladder hernias in the published literature [1-4] and no case of Totally Extraperitoneal (TEP) approach planned. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  12. Dynamics of transparent exopolymer particles (TEP) during the VAHINE mesocosm experiment in the New Caledonian lagoon

    Science.gov (United States)

    Berman-Frank, Ilana; Spungin, Dina; Rahav, Eyal; Van Wambeke, France; Turk-Kubo, Kendra; Moutin, Thierry

    2016-07-01

    In the marine environment, transparent exopolymeric particles (TEP) produced from abiotic and biotic sources link the particulate and dissolved carbon pools and are essential vectors enhancing vertical carbon flux. We characterized spatial and temporal dynamics of TEP during the VAHINE experiment that investigated the fate of diazotroph-derived nitrogen and carbon in three replicate dissolved inorganic phosphorus (DIP)-fertilized 50 m3 enclosures in the oligotrophic New Caledonian lagoon. During the 23 days of the experiment, we did not observe any depth-dependent changes in TEP concentrations in the three sampled depths (1, 6, 12 m). TEP carbon (TEP-C) content averaged 28.9 ± 9.3 and 27.0 ± 7.2 % of total organic carbon (TOC) in the mesocosms and surrounding lagoon respectively and was strongly and positively coupled with TOC during P2 (i.e., days 15-23). TEP concentrations in the mesocosms declined for the first 9 days after DIP fertilization (P1 = days 5-14) and then gradually increased during the second phase. Temporal changes in TEP concentrations paralleled the growth and mortality rates of the diatom-diazotroph association of Rhizosolenia and Richelia that predominated the diazotroph community during P1. By P2, increasing total primary and heterotrophic bacterial production consumed the supplemented P and reduced availability of DIP. For this period, TEP concentrations were negatively correlated with DIP availability and turnover time of DIP (TDIP), while positively associated with enhanced alkaline phosphatase activity (APA) that occurs when the microbial populations are P stressed. During P2, increasing bacterial production (BP) was positively correlated with higher TEP concentrations, which were also coupled with the increased growth rates and aggregation of the unicellular cyanobacterial Group C (UCYN-C) diazotrophs that bloomed during this period. We conclude that the composite processes responsible for the formation and breakdown of TEP yielded a

  13. Developpement d'outils quantitatifs pour le suivi par imagerie TEP/TDM de la reponse a la chimiotherapie et de sa toxicite

    Science.gov (United States)

    Croteau, Etienne

    L'objectif de ce projet de doctorat est de developper des outils quantitatifs pour le suivi des traitements de chimiotherapie pour le cancer du sein et de leurs effets cardiotoxiques a l'aide de l'imagerie TEP dynamique. L'analyse cinetique en TEP dynamique permet l'evaluation de parametres biologiques in vivo. Cette analyse peut etre utilise pour caracteriser la reponse tumorale a la chimiotherapie et les effets secondaires nefastes qui peuvent en resulter. Le premier article de cette these decrit la mise au point des techniques d'analyse cinetique qui utilisent la fonction d'entree d'un radiotraceur derive de l'image dynamique. Des corrections de contamination radioactive externe (epanchement) et de l'effet de volume partiel ont ete necessaires pour standardiser l'analyse cinetique et la rendre quantitative. Le deuxieme article porte sur l'evaluation d'un nouveau radiotraceur myocardique. Le 11C-acetoacetate, un nouveau radiotraceur base sur un corps cetonique, a ete compare au 11C-acetate, couramment utilise en imagerie cardiaque TEP. L'utilisation de 3H-acetate et 14C-acetoacetate ont permis d'elucider la cinetique de ces traceurs depuis la fonction d'entree et la captation par les mitochondries cardiaques qui reflete la consommation en oxygene, jusqu'a la liberation de leurs principaux metabolites reciproques (3H20 et 14CO2). Le troisieme et dernier article de cette these presente l'integration d'un modele qui evalue la reserve cardiaque de perfusion et de consommation en oxygene. Un modele de cardiomyopathie a ete etabli a l'aide d'un agent chimiotherapeutique contre le cancer du sein, la doxorubicine, reconnu comme etant cardiotoxique. Un protocole de repos/effort a permis d'evaluer la capacite d'augmentation de perfusion et de consommation en oxygene par le coeur. La demonstration d'une reserve cardiaque reduite caracterise la cardiotoxicite. La derniere contribution de cette these porte sur la mise au point de methodes peu invasives pour mesurer la

  14. Transparent exopolymer particles (TEP)-associated membrane fouling at different Na+ concentrations.

    Science.gov (United States)

    Meng, Shujuan; Liu, Yu

    2017-03-15

    Membrane filtration has been widely applied for water treatment, wastewater reclamation and seawater desalination. Although extensive research work has been conducted to better understand the fouling mechanism under various conditions, little has been known about the transparent exopolymer particles (TEP)-associated membrane fouling at different Na+ concentrations. In this study, the influence of Na+ concentration on the TEP formation as well as the filtration behaviors of alginate blocks was investigated. Results showed that increasing Na+ concentration substantially reduced the TEP formation from all types of alginate blocks, thus preventing the cake layer development on the membrane surface. As a result, the TEP-associated membrane fouling was found to be kinetically slower and much less at higher Na+ level. Furthermore, filtration tests of alginate blocks at freshwater and seawater conditions were also conducted, showing that TEP-associated fouling in freshwater is much server than that in seawater at the defined conditions. This study reveals that the TEP formation is significantly influenced by the chemistry condition of bulk solution and membrane fouling is profoundly affected by the TEP levels in feed water. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. A pseudo-TEP repair of an incarcerated obturator hernia.

    Science.gov (United States)

    Maricevich, Marco; Farley, David

    2011-01-01

    Obturator hernia (OH) is a rare condition and difficult to diagnose. While they account for as few as 0.073% of all hernias, mortality can be as high as 70%. The typical clinical presentation for OH is small bowel obstruction. Computed tomography is the diagnostic tool of choice. Surgical repair is mandatory in virtually all cases of OH and traditionally consists of performing an exploratory laparotomy. A 90-year-old female was admitted to our surgical service with signs of small bowel obstruction and a CT scan revealing incarcerated fatty tissue and small bowel within a left OH. The role of laparoscopic surgery in the management of OH has been limited to elective repairs; most reports detail that the OH was found serendipitously during laparoscopic inguinal hernia operations or other pelvic procedures. A few reports describe the use of laparoscopy to treat OH associated with bowel obstruction in an emergency setting using a TAPP approach. A strict TEP hernia repair is not indicated for all patients with OH, and should rarely be performed in emergency situations given its limitation to assess or resect bowel if necessary. In selected cases, a formal exploratory laparoscopy that is negative for compromised bowel can be safely followed by a TEP repair using the same umbilical access as shown in our patient. A 90-year-old female with a small bowel obstruction related to an incarcerated OH was treated effectively with an extraperitoneal laparoscopic approach.

  16. An insect TEP in a crustacean is specific for cuticular tissues and involved in intestinal defense.

    Science.gov (United States)

    Wu, Chenglin; Noonin, Chadanat; Jiravanichpaisal, Pikul; Söderhäll, Irene; Söderhäll, Kenneth

    2012-02-01

    In an attempt to identify genes encoding thioester-containing proteins in the freshwater crayfish, Pacifastacus leniusculus, three different cDNAs were found. A phylogenetic analysis of these proteins indicates that they can be classified into two subfamilies: two alpha-2-macroglobulins (Pl-A2M1, Pl-A2M2) showing a close similarity to shrimp A2M, and one insect TEP-like protein (Pl-TEP). This is the first report of an insect TEP-like protein in a crustacean. Crayfish Pl-A2M1, Pl-A2M2 and Pl-TEP cDNAs encode proteins with 1480, 1586 or 1507 amino acids, respectively. Pl-A2M1, Pl-A2M2 and Pl-TEP have the basic domain structure and functionally important residues for each molecule, and their mRNA was detected in different parts of the body, suggesting that they may have different functions. Pl-A2M1 was mainly expressed in hemocytes and Pl-A2M2 was highly expressed in heart and nerve, while Pl-TEP was exclusively expressed in cuticular tissues such as gill and intestine. RNA interference of Pl-TEP in vivo resulted in that these animals were slightly less resistant when fed with the bacterium, Pseudomonas libanensis/gessardii. Furthermore, when TEP activity was blocked using methylamine followed by bacterial feeding, the animals were killed to a higher extent compared to a control group. Taken together, this indicates that Pl-TEP and/or Pl-A2M1, Pl-A2M2 may be important for the immune defense in crayfish intestine and function as a pattern recognition protein in crayfish cuticular tissues. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Comparison of Alcian blue and total carbohydrate assays for quantitation of transparent exopolymer particles (TEP) in biofouling studies.

    Science.gov (United States)

    Li, Xu; Skillman, Lucy; Li, Dan; Ela, Wendell P

    2018-04-15

    Transparent exopolymer particles (TEP) and their precursors are gel-like acidic polysaccharide particles. Both TEP precursors and TEP have been identified as causal factors in fouling of desalination and water treatment systems. For comparison between studies, it is important to accurately measure the amount and fouling capacity of both components. However, the accuracy and recovery of the currently used Alcian blue based TEP measurement of different surrogates and different size fractions are not well understood. In this study, we compared Alcian blue based TEP measurements with a total carbohydrate assay method. Three surrogates; xanthan gum, pectin and alginic acid; were evaluated at different salinities. Total carbohydrate concentrations of particulates (>0.4 μm) and their precursors (10 kDa) varied depending on water salinity and method of recovery. As xanthan gum is the most frequently used surrogate in fouling studies, TEP concentration is expressed as xanthan gum equivalents (mg XG eq /L) in this study. At a salinity of 35 mg/L sea salt, total carbohydrate assays showed a much higher particulate TEP fraction for alginic acid (38%) compared to xanthan gum (9%) and pectin (12%). The concentrations of particulate TEP therefore may only represent ∼10% of the total mass; while precursor TEP represents ∼80% of the total TEP. This highlights the importance of reporting both particulate and precursor TEP for membrane biofouling studies. The calculated concentrations of TEP and their precursors in seawater samples are also highly dependent on type of surrogate and resulting calibration factor. A linear correlation between TEP recovery and calibration factor was demonstrated in this study for all three surrogates. The relative importance and accuracy of measurement method, particulate size, surrogate type, and recovery are described in detail in this study. Copyright © 2017. Published by Elsevier Ltd.

  18. TAPP or TEP? Population-based analysis of prospective data on 4,552 patients undergoing endoscopic inguinal hernia repair.

    Science.gov (United States)

    Gass, Markus; Banz, Vanessa M; Rosella, Laura; Adamina, Michel; Candinas, Daniel; Güller, Ulrich

    2012-12-01

    Whether total extraperitoneal inguinal hernia repair (TEP) is associated with worse outcomes than transabdominal preperitoneal inguinal hernia repair (TAPP) continues to be a matter of debate. The objective of this large cohort study is to compare outcomes between patients undergoing TEP or TAPP. Based on prospective data of the Swiss association of laparoscopic and thoracoscopic surgery, all patients undergoing unilateral TEP or TAPP between 1995 and 2006 were included. The following outcomes were compared: conversion rates, intraoperative and postoperative complications, duration of operation. Data on 4,552 patients undergoing TEP (n=3,457) and TAPP (n=1,095) were collected prospectively. Average age and American Society of Anesthesiologists score were similar in the two groups. Patients undergoing TEP had a significantly higher rate of intraoperative complications (TEP 1.9% vs. TAPP 0.9%, p=0.029) and surgical postoperative complications (TEP: 2.3% vs. TAPP: 0.8%, p=0.003). The postoperative length of stay was longer for patients undergoing TAPP (2.9 vs. 2.3 days, p=0.002), whereas the duration of the operation was longer for TEP (66.6 vs. 59.0 min, pTEP 1.0% vs. TAPP 0.2%, p=0.011). This study is one of the first population-based analyses comparing TEP and TAPP in a prospective cohort of more than 4,500 patients. Intraoperative and surgical postoperative complications were significantly higher in patients undergoing TEP. TEP is also associated with longer operating times and higher conversion rates. Therefore, on a population-based level, the TAPP technique appears to be superior to the TEP repair in patients undergoing unilateral inguinal hernia repair.

  19. A comparative study of standard versus laparoendoscopic single-site surgery (LESS) totally extraperitoneal (TEP) inguinal hernia repair.

    Science.gov (United States)

    Tai, Huai-Ching; Lin, Chia-Da; Chung, Shiu-Dong; Chueh, Shih-Chieh Jeff; Tsai, Yao-Chou; Yang, Stephen Shei-Dei

    2011-09-01

    Laparoscopic inguinal hernia repair has been around since the 1990s. A novel surgical approach known as laparoendoscopic single-site surgery (LESS) has been developed to reduce the port-related morbidities and improve the cosmetic outcomes of laparoscopic surgery, including totally extraperitoneal (TEP) inguinal hernia repair. The aim of the present study was to evaluate the safety and feasibility of the LESS TEP technique for inguinal hernia repair and compare the outcomes with the standard TEP approach. Between January and May 2009, 54 consecutive healthy patients (48 men and 6 women) underwent LESS TEP inguinal hernia repair at our institute. All procedures were performed using our homemade single port for simultaneous passage of the laparoscope and instruments. The perioperative data, including patient age, sex, body mass index (BMI), hernia characteristics, operative time, complications, length of hospital stay, return to normal activity, pain score, and cosmetic result, were prospectively collected. All LESS TEP procedures were completed successfully without conversion to standard laparoscopic or open surgery. A total of 98 LESS TEP hernia repairs were performed in 54 patients and compared with 152 standard TEP operations. The mean operative time was significantly shorter in the standard TEP series (61.8 ± 26.0 vs. 70.9 ± 23.8 min, p = 0.04). Other perioperative parameters, including the length of hospital stay, time until return to full activity, complication rate, pain score, and cosmetic result, were all comparable between the two techniques. Our short-term experience with LESS TEP inguinal hernia repair has shown that in experienced hands, inguinal hernia repair via the LESS TEP technique is as safe as the standard TEP technique. However, based on our evidence, we currently believe that the LESS TEP technique is not an efficacious surgical alternative to the standard TEP technique for inguinal hernias.

  20. COTS Software Decision Support Models for USPACOM's Theater Engagement Plan (TEP)

    National Research Council Canada - National Science Library

    Taylor, John

    2000-01-01

    .... USPACOM's Theater Engagement Plan (TEP) contributes to the accomplishment of this mission by planning, coordinating, and implementing peacetime military activities to shape the region's security environment. USPACOM, J56...

  1. Laparoscopic (TEP) versus Lichtenstein inguinal hernia repair: a comparison of quality-of-life outcomes.

    Science.gov (United States)

    Myers, Eddie; Browne, Katherine M; Kavanagh, Dara O; Hurley, Michael

    2010-12-01

    Laparoscopic inguinal hernia repair has emerged as a viable alternative to the open procedure. To date, few studies have included validated measures of quality of life as end points. We compared quality-of-life outcomes following laparoscopic versus open repair of inguinal hernia. All laparoscopic repairs were performed via the totally extraperitoneal route (TEP). All open procedures were Lichtenstein repairs (LR). Hernia repairs performed between January 1999 and December 2006 were included in the study. Data was recorded prospectively and each TEP repair was matched with a LR for analysis. The SF-36 form was used to assess quality of life. Statistical significance was determined using the two-sample Wilcoxon rank-sum (Mann-Whitney) test. Three hundred fourteen procedures were performed during the study period, 164 (52%) had a TEP repair and 150 (48%) had a LR. Ninety TEP repairs were matched with 90 LR. Recurrence rates were 3% following TEP repair and 2% following LR. There was a significant difference between the laparoscopic and open groups in terms of physical function (p = 0.0001), physical role (p TEP repair results in less postoperative pain, a quicker return to normal functional status, and improved quality-of-life outcomes with equivalent recurrence rates when compared to the LR.

  2. Abundance, size distribution and bacterial colonization of transparent exopolymeric particles (TEP) during spring in the Kattegat

    DEFF Research Database (Denmark)

    Mari, X.; Kiørboe, Thomas

    1996-01-01

    The abundance, size distribution and bacterial colonization of transparent exopolymeric particles (TEP) were monitored in the Kattegat (Denmark) at weekly intervals throughout the spring (February-May) encompassing the spring diatom bloom. These recently discovered particles are believed to be fo......The abundance, size distribution and bacterial colonization of transparent exopolymeric particles (TEP) were monitored in the Kattegat (Denmark) at weekly intervals throughout the spring (February-May) encompassing the spring diatom bloom. These recently discovered particles are believed...... to be formed from colloidal organic material exuded by phytoplankton and bacteria, and may have significant implications for pelagic flux processes. During this study, the number concentration of TEP (>1 mu m) ranged from 3 x 10(3) to 6 x 10(4) ml(-1) and the volume concentration between 0.3 and 9.0 p.......p.m.; they were most abundant in the surface waters subsequent to the spring phytoplankton bloom. The range of TEP (encased) volume concentration was similar to that of the phytoplankton, although at times TEP volume concentration exceeded that of the phytoplankton by two orders of magnitude. The TEP size...

  3. New insights into transparent exopolymer particles (TEP) formation from precursor materials at various Na+/Ca2+ ratios

    Science.gov (United States)

    Meng, Shujuan; Liu, Yu

    2016-01-01

    Transparent exopolymer particles (TEP) are planktonic, organic microgels which play significant roles in cycling of carbon and trace elements, aggregation of particles, feeding and accommodating microbes as well as development of biofilms. However, few studies are available on the mechanism of TEP formation in various water environments. Here we investigate the formation of TEP with alginate blocks as precursors at various Na+/Ca2+ ratios to simulate the situations in different aquatic environments (e.g. freshwater and seawater). We found that the formation of TEP from precursor materials studied was essentially determined by the Ca2+ concentration at a fixed sodium concentration, while Na+ at high Na+/Ca2+ ratio out-competed Ca2+ for the binding sites on the precursor molecules, leading to a significantly decreased trend of TEP formation. Our results indicate that a more abundant TEP could be expected in freshwater than in seawater, and we also discuss the engineering implications of the findings.

  4. Totally extraperitoneal (TEP) bilateral hernioplasty using the Single Site® robotic da Vinci platform (DV-SS TEP): description of the technique and preliminary results.

    Science.gov (United States)

    Cestari, A; Galli, A C; Sangalli, M N; Zanoni, M; Ferrari, M; Roviaro, G

    2017-06-01

    Laparoendoscopic single site totally extraperitoneal (TEP) hernia repair showed to be a feasible alternative to conventional laparoscopic hernia repair; nevertheless single site surgery, with the loss of instruments triangulation can be a demanding procedure. To overcome those hurdles, the Single Site® (SS) platform of the da Vinci (DV) Si robotic system enables to perform surgical procedures through a 25-mm skin incision, with a stable 3D vision and restoring an adequate triangulation of the surgical instruments. We present in details the technique and the preliminary results of DV-SS TEP, to our knowledge the first cases reported in literature. In March 2016, three consecutive male patients (mean age 46.6 years-mean BMI 25.3) with bilateral symptomatic inguinal hernia were submitted to DV-SS TEP in our institutions. Feasibility, codification of the technique, operative time and perioperative outcomes were recorded. All the procedures were completed as scheduled, with no conversion to other techniques. Mean operative time was 98.6 min, ranging between 155 and 55 min, reflecting the learning curve of the operating room team on this new procedure. No intraoperative or postoperative complications were experienced and all the patients were discharged within 24 h after surgery. Patients reported satisfactory postoperative course, with no recurrence of inguinal hernia and satisfaction in cosmetic result at 6-month follow-up. DV-SS TEP inguinal hernia repair showed to be feasible and effective surgical option for bilateral groin hernia repair. Patients' outcome was uneventful, with optimal cosmetic results. Further studies comparing this innovative technique to TEP or LESS TEP should be promoted.

  5. Direct application of single-port laparoscopic totally extraperitoneal (TEP) inguinal hernia repair by an experienced single-port laparoscopic surgeon who was inexperienced in conventional TEP hernia repair: initial experience with 100 cases.

    Science.gov (United States)

    Choi, Byung-Jo; Lee, Kwan Ju; Lee, Sang Chul

    2014-05-01

    Single-port laparoscopic surgery (SPLS) has been introduced for totally extraperitoneal (TEP) inguinal hernia repair. The aim of this study was to report our initial experience with SPLS TEP inguinal hernia repair in 100 patients by a single-port laparoscopic surgeon who had no prior experience of conventional TEP hernia repair. Between October 2012 and December 2013, 100 patients underwent SPLS TEP inguinal hernia repair by a single surgeon. The procedures that were performed in the preperitoneal space did not differ from those in conventional TEP repair. Patient demographics, type of hernia, and operative and postoperative outcomes were analyzed. Also, we compared the results of current series with the data of the other studies for single-port TEP inguinal hernia repair. Among the 100 patients, SPLS TEP inguinal hernia repair was successful in 99 patients; 1 patient required additional incisions for inserting the trocar. The mean operative time and postoperative length of stay were 97.8 minutes (range, 55-185 minutes) and 1.3 days (range, 1-4 days), respectively. In the current series, the operation time was longer than those in the other studies for SPLS TEP repair. Recurrent hernia, history of lower abdominal surgery, and peritoneal tear during the operation were significantly associated with prolonged operation time. The other data, including perioperative complications, were similar. In our experience, the transition from standard hernioplasty to SPLS TEP inguinal hernia repair by an experienced SPLS surgeon was feasible. However, a learning curve is necessary.

  6. Endoscopic TEP hernia repair. Experience in a high volume center allows for recommendations concerning still unsolved questions

    OpenAIRE

    Schouten, N.

    2013-01-01

    The aim of this thesis is the endoscopic TEP hernia repair, which is an appealing technique for patients with inguinal hernias. TEP, offering an adequate intraoperative diagnosis and subsequent treatment of all hernia subtypes is in experienced hands associated with low recurrence rates and rates of (chronic) postoperative pain. The supposedly substantial learning curve remains its most important disadvantage, emphasizing the need to have TEP performed by experienced surgeons. Limited and con...

  7. [Total extraperitoneal endoscopic hernioplasty (TEP) in the treatment of incarcerated and irreponible inguinal and femoral hernias].

    Science.gov (United States)

    Mainik, F; Flade-Kuthe, R; Kuthe, A

    2005-12-01

    To estimate the value of TEP in the treatment of incarcerated and irreponible inguinal and femoral hernias more exactly we prospectively collected and evaluated the data of our clinic for the period of Oct. 1999 until Dec. 2003. In this period we performed in total 1 671 hernia repairs including 79 patients suffering from an incarcerated (n = 33) or irreponible (n = 46) inguinal or femoral hernia. Using only the TEP-technique we treated mainly the irreponible hernias (46 patients). In the combination of LAP (laparoscopy) and TEP (27 patients) the laparoscopy provided the possibility to classify as well the incarcerated tissue as the result of the reposition. With this combined technique we treated the majority of the incarcerated hernias. To confirm the recovery of the incarcerated tissue laparoscopy can be of high value at the end of the combined LAP + TEP (2 patients). Thus TEP was performed in 92 % of the cases. In 2 cases we performed a conventional hernioplasty and one operation was finished conventionally after switching from endoscopic to conventional procedure. In 2 patients we performed a laparoscopically supported resection of the incarcerated tissue without patch implantation. 1 patient acquired TAPP. The use of different operative techniques and their combinations demonstrates as well the possibility as the necessity of a differentiated and case adapted proceeding in the treatment of incarcerated hernias. Lethality with 1.2 % and early postoperative morbidity with only 5.0 % were low. The hospitalisation period was 4.7 d on average. Our results are comparable to results of literature and show that TEP-technique and combined TEP + LAP-technique are possible and reasonable for the treatment of incarcerated and irreponible hernias.

  8. Single incision laparoscopic totally extraperitoneal hernioplasty (SIL-TEP): experience of 512 procedures.

    Science.gov (United States)

    Kim, J H; An, C H; Lee, Y S; Kim, H Y; Lee, J I

    2015-06-01

    Reports have been issued recently on single incision laparoscopic hernioplasty, but no large-scale study has been conducted as yet. This study aimed to assess the safety and feasibility of the single incision laparoscopic totally extraperitoneal hernioplasty (SIL-TEP) on a large number of cases. 512 SIL-TEPs in 471 patients were performed from June 2010 to January 2014 at Incheon St. Mary's Hospital, The Catholic University of Korea. SIL-TEP was performed using a glove single port device and standard laparoscopic instruments. Short-term outcomes were reviewed. Of the 512 hernias, 329 (64.3 %) were indirect, 144 (28.1 %) were direct, 9 (1.8 %) were femoral, and 30 (5.9 %) were combined. There were 3 (0.6 %) conversions to single or three-port laparoscopic transabdominal preperitoneal hernioplasty. Mean operative time was 41.6 min for unilateral hernias and 65.3 min for bilateral hernias. Postoperative complications occurred in 45 cases (9.6 %); 21 were wound seromas, 5 were hematomas, and 18 were urinary retentions. All were successfully treated conservatively. Mean hospital stay was 1.8 days. The SIL-TEP is safe and technically feasible. Additional studies on long-term recurrence rates are needed to confirm the safety of SIL-TEP.

  9. A Study of NSF Teacher Enhancement Program (TEP) Participants and Principal Investigators: 1984-1989. Volume I: Summary Report.

    Science.gov (United States)

    Abt Associates, Inc., Cambridge, MA.

    The National Science Foundation (NSF) supported more than 600 inservice teacher training programs between 1984 and 1989 under its Teacher Enhancement Program (TEP). Two studies were undertaken of TEP: the first was a survey of the 600 Principal Investigators (PIs) who had operated inservice teacher enhancement projects and the second, a survey of…

  10. Endoscopic TEP hernia repair. Experience in a high volume center allows for recommendations concerning still unsolved questions

    NARCIS (Netherlands)

    Schouten, N.

    2013-01-01

    The aim of this thesis is the endoscopic TEP hernia repair, which is an appealing technique for patients with inguinal hernias. TEP, offering an adequate intraoperative diagnosis and subsequent treatment of all hernia subtypes is in experienced hands associated with low recurrence rates and rates of

  11. Seasonal distribution and correlates of transparent exopolymer particles (TEP) in the waters surrounding mangroves in the Sundarbans

    Science.gov (United States)

    Chowdhury, Chumki; Majumder, Natasha; Jana, Tapan Kumar

    2016-06-01

    In situ concentration of transparent exopolymer particles (TEP) are usually associated with phytoplankton dominated by diatoms and their release of precursor polysaccharide material in the aquatic system. Here, we present temporal data on TEP variation and related habitat parameters for waters surrounding mangroves in the Sundarbans located at the coastal boundary of the Ganges River delta. Over three study years (2009-2011), TEP concentration was highest during the post-monsoon period and was mainly a function of phytoplankton production. The most common diatom species (by percentage of relative abundance) were Skeletonema cf. costatum (Cleve 1873), Ditylum brightwellii (Gosse 1850), and Chaetoceros sp. During the post-monsoon, when phytoplankton was abundant TEP/Chl-a ratio was relatively low and as nutrients depleted from water, phytoplankton biomass declined subsequently, increasing mean TEP/Chl-a ratio in the pre-monsoon.

  12. The safety and effectiveness of laparoscopic total extraperitoneal (TEP) repair for recurrent inguinal hernia after open hernioplasty.

    Science.gov (United States)

    Choi, Yoon Young; Kim, Zisun; Hur, Kyung Yul

    2010-01-01

    Many studies have reported that laparoscopic total extraperitoneal (TEP) repair for recurrent inguinal hernia after an open hernioplasty was safe and effective. This study was conducted to evaluate TEP repair for recurrent inguinal hernia through a retrospective analysis of our data. We performed a retrospective analysis of the medical records of patients who were scheduled for laparoscopic TEP repair from December 2000 to December 2008. A total of 1065 cases of laparoscopic TEP repairs were performed for 944 patients by a single surgeon, and 100 cases of recurrent inguinal hernias were enrolled. The mean operation time was longer in the recurrent hernia group than that in the primary hernia group (P TEP repair is safe and effective for treating recurrent inguinal hernia after an open hernioplasty, because the recurrence rate was low (2%) and other complications were similar for both groups. Direct inguinal hernia was more frequent in patients who had recurrent inguinal hernia.

  13. The fate of Transparent Exopolymer Particles (TEP) in integrated membrane systems: removal through pre-treatment processes and deposition on reverse osmosis membranes.

    Science.gov (United States)

    Villacorte, Loreen O; Kennedy, Maria D; Amy, Gary L; Schippers, Jan C

    2009-12-01

    The abundance of Transparent Exopolymer Particles (TEP) in surface waters has been unnoticed for many years until recently as a potential foulant in reverse osmosis systems. Recent studies indicate that TEP may cause organic and biological fouling and may enhance particulate/colloidal fouling in reverse osmosis membranes. The presence of TEP was measured in the raw water, the pre-treatment processes and reverse osmosis (RO) systems of 6 integrated membrane installations. A spectrophotometric method was used to measure TEP in the particulate size range (>0.40microm) and was extended to measure TEP in the colloidal size range (0.05-0.40microm). Ultrafiltration pre-treatment applied in 4 plants, totally removed particulate TEP while microfiltration systems (2 plants) and coagulation/sedimentation/rapid sand filtration systems (3 plants) partially removed this fraction. None of the pre-treatment systems investigated totally removed colloidal TEP. Biopolymer analysis using LC-OCD showed consistency between colloidal TEP and polysaccharide removal by UF pre-treatment and further verified the presence of TEP in the RO feedwater. TEP deposition in the RO system was determined after measuring total TEP concentrations in the RO feed and concentrate. The TEP deposition factors and specific deposition rates indicate that TEP accumulation had occurred in all plants investigated. This observation was verified by an autopsy of RO modules from two RO plants. Further improvement and verification of the (modified) TEP method, in particular the calibration, is necessary so that it can be employed to investigate the role of TEP in the fouling of RO systems.

  14. Pain after totally extraperitoneal (TEP) hernia repair might fade out within a year.

    Science.gov (United States)

    Burgmans, J P J; Schouten, N; Clevers, G J; Verleisdonk, E J M M; Davids, P H P; Voorbrood, C E H; Simmermacher, R K J; Van Dalen, T

    2015-08-01

    The incidence of chronic pain after endoscopic hernia repair varies between 1 and 16 %. Studies regarding the course of pain in time after the operation are scarce. 473 male patients ≥18 years of age, scheduled for totally extraperitoneal (TEP) hernia repair (Prolene® mesh) between March 2010 and August 2012 were requested to record pain symptoms preoperative, and 1 day, 1 week, 6 weeks, 3 months and 1 year postoperatively and visit the outpatient department 3 months and 1 year postoperatively for a standardized interview and physical examination. Preoperatively, 25 % (n = 114) of the patients had moderate-to-severe pain (NRS 4-10). Six weeks postoperatively, 3 % (n = 12) of the patients still experienced moderate-to-severe pain. Three months after TEP, only 3 patients (0.6 %) had moderate-to-severe pain, while 83 patients (18 %) experienced mild pain. One year after TEP, 39 patients experienced mild pain (8 %) and 3 patients moderate pain (0.7 %), no patients experienced severe pain after 1 year. Patients with moderate-to-severe pain preoperatively had a higher risk of pain persisting until 3 months and 1 year postoperatively (p = 0.03). In most patients who had pain 3 months postoperatively and were pain-free 1 year after TEP, pain 'faded out' at 4-6 months postoperatively. Two patients had a not-painful recurrent hernia, diagnosed 2 and 5 months after TEP repair. Moderate-to-severe pain after TEP hernia repair is self-limiting, with less than 1 % of the patients reporting moderate pain 1 year postoperatively.

  15. Prospective, comparative study of postoperative quality of life in TEP, TAPP, and modified Lichtenstein repairs.

    Science.gov (United States)

    Belyansky, Igor; Tsirline, Victor B; Klima, David A; Walters, Amanda L; Lincourt, Amy E; Heniford, Todd B

    2011-11-01

    The purpose of this study was to compare postoperative quality of life (QOL) in patients undergoing laparoscopic totally extraperitoneal (TEP), transabdominal preperitoneal (TAPP), or modified Lichtenstein (ML) hernia repairs. The International Hernia Mesh Registry (2007-2010) was interrogated. 2086 patients who underwent 2499 inguinal hernia repairs were identified. A Carolinas Comfort Score was self-reported at 1-, 6-, 12-months and results were compared. Subgroups analysis and logistic regression were used to identify confounders and to control for significant variables. One hundred seventy-two patients met the exclusion criteria. The distribution of unilateral procedures was TEP (n = 217), TAPP (n = 331), and ML (n = 953). Average follow-up was 12 months. Use of >10 tacks, lack of prostate pathology, recurrent hernia repairs, and bilateral hernia repairs were significant predictors of postoperative pain. One month after surgery 8.9%, 16.6%, and 16.5% were symptomatic for TEP (P = 0.038 vs. ML), TAPP and ML, respectively. At 6 months and 1 year no differences were observed. The number of tacks used varied significantly, with 18.1% of TAPP and 2.3% of TEP with >10 tacks (P = 0.005). The incidence of hernia recurrences were equivalent: TEP (0.42%), TAPP (1.34%), and ML (1.27%). The number or type of tacks utilized did not impact recurrence rates. Use of >10 tacks doubles the incidence of early postoperative pain while having no effect on rates of recurrence. There was no difference in chronic postoperative pain comparing ML, TEP, and TAPP including when controlled for tack use.

  16. Female 'groin' hernia: totally extraperitoneal (TEP) endoscopic repair seems the most appropriate treatment modality.

    Science.gov (United States)

    Schouten, N; Burgmans, J P J; van Dalen, T; Smakman, N; Clevers, G J; Davids, P H P; Verleisdonk, E J M M; Elias, S G; Simmermacher, R K J

    2012-08-01

    About 30% of all female 'groin' hernias are femoral hernias, although often only diagnosed during surgery. A Lichtenstein repair though, as preferred treatment modality according to guidelines, would not diagnose and treat femoral hernias. Totally extraperitoneal (TEP) hernia repair, however, offers the advantage of being an appropriate modality for the diagnosis and subsequent treatment of both inguinal and femoral hernias. TEP therefore seems an appealing surgical technique for women with groin hernias. This study included all female patients ≥ 18 years operated for a groin hernia between 2005 and 2009. A total of 183 groin hernias were repaired in 164 women. TEP was performed in 85% of women; the other 24 women underwent an open anterior (mesh) repair. Peroperatively, femoral hernias were observed in 23% of patients with primary hernias and 35% of patients with recurrent hernias. There were 30 cases (18.3%) of an incorrect preoperative diagnosis. Peroperatively, femoral hernias were observed in 17.3% of women who were diagnosed with an inguinal hernia before surgery. In addition, inguinal hernias were found in 24.0% of women who were diagnosed with a femoral hernia preoperatively. After a follow-up of 25 months, moderate to severe (VAS 4-10) postoperative pain was reported by 8 of 125 patients (6.4%) after TEP and 5 of 23 patients (21.7%) after open hernia repair (P = 0.03). Five patients had a recurrent hernia, two following TEP (1.4%) and three following open anterior repair (12.5%, P = 0.02). Two of these three patients presented with a femoral recurrence after a previous repair of an inguinal hernia. Femoral hernias are common in women with groin hernias, but not always detected preoperatively; this argues for the use of a preperitoneal approach. TEP hernia repair combines the advantage of a peroperative diagnosis and subsequent appropriate treatment with the known good clinical outcomes.

  17. Selecting patients during the "learning curve" of endoscopic Totally Extraperitoneal (TEP) hernia repair.

    Science.gov (United States)

    Schouten, N; Elshof, J W M; Simmermacher, R K J; van Dalen, T; de Meer, S G A; Clevers, G J; Davids, P H P; Verleisdonk, E J M M; Westers, P; Burgmans, J P J

    2013-12-01

    Totally Extraperitoneal (TEP) hernia surgery is associated with little postoperative pain and a fast recovery, but is a technically demanding operative procedure. Apart from the surgeon's expertise, patient characteristics and hernia-related variations may also affect the operative time and outcome. Patient-related factors predictive of perioperative complications, conversion to open anterior repair, and operative time were studied in a cohort of consecutive patients undergoing TEP hernia repair from 2005 to 2009. A total of 3,432 patients underwent TEP. The mean operative time was 26 min (SD ± 10.9), TEP was converted into an open anterior approach in 26 patients (0.8 %), and perioperative complications were observed in 55 (1.6 %) patients. Multivariable regression analysis showed that a history of abdominal surgery (OR 1.76, 95 per cent confidence interval 1.01-3.06; p = 0.05), and the presence of a scrotal (OR 5.31, 1.20-23.43; p = 0.03) or bilateral hernia (OR 2.25, 1.25-4.06; p = 0.01) were independent predictive factors of perioperative complications. Female gender (OR 5.30. 1.52-18.45; p = 0.01), a history of abdominal surgery (OR 3.96, 1.72- 9.12; p = 0.001), and the presence of a scrotal hernia (OR 34.84, 10.42-116.51, p TEP surgeons, associated with an increased risk of conversion and complications and a longer operative time. For the surgeon gaining experience with TEP, it seems advisable to select relatively young and slender male patients with a unilateral (non-scrotal) hernia and no previous abdominal surgery to enhance patient safety and 'surgeon comfort'.

  18. Endoscopic totally extraperitoneal (TEP) hernia repair for inguinal disruption (Sportsman's hernia): rationale and design of a prospective observational cohort study (TEP-ID-study).

    Science.gov (United States)

    Voorbrood, C E H; Goedhart, E; Verleisdonk, E J M M; Sanders, F; Naafs, D; Burgmans, J P J

    2016-01-06

    Chronic inguinal pain is a frequently occurring problem in athletes. A diagnosis of inguinal disruption is performed by exclusion of other conditions causing groin pain. Up to now, conservative medical management is considered to be the primary treatment for this condition. Relevant large and prospective clinical studies regarding the treatment of inguinal disruption are limited; however, recent studies have shown the benefits of the totally extraperitoneal patch (TEP) technique.This study provides a complete assessment of the inguinal area in athletes with chronic inguinal pain before and after treatment with the TEP hernia repair technique. We describe the rationale and design of an observational cohort study for surgical treatment with the endoscopic TEP hernia repair technique in athletes with a painful groin (inguinal disruption).The study is being conducted in a high-volume, single centre hospital with specialty in TEP hernia repair. Patients over 18 years, suffering from inguinal pain for at least 3 months during or after playing sports, and whom have not undergone previous inguinal surgery and have received no benefit from physiotherapy are eligible for inclusion. Patients with any another cause of inguinal pain, proven by physical examination, inguinal ultrasound, X-pelvis/hip or MRI are excluded.Primary outcome is reduction in pain after 3 months. Secondary outcomes are pain reduction, physical functioning, and resumption of sport (in frequency and intensity). An unrestricted research grant for general study purposes was assigned to the Hernia Centre. This study itself is not directly subject to the above mentioned research grant or any other financial sponsorship. We intend to publish the outcome of the study, regardless of the findings. All authors will give final approval of the manuscript version to be published. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  19. Transparent Exopolymer Particles (TEP) in the NE Aegean Sea frontal area: Seasonal dynamics under the influence of Black Sea water

    Science.gov (United States)

    Parinos, C.; Gogou, A.; Krasakopoulou, E.; Lagaria, A.; Giannakourou, A.; Karageorgis, A. P.; Psarra, S.

    2017-10-01

    The abundance of Transparent Exopolymer Particles (TEP) was determined on a seasonal basis (autumn, spring and summer) along a north-south transect in the NE Aegean Sea and the vicinity of the Dardanelles Straits. Their distribution patterns were studied in respect to hydrographic conditions and water mass characteristics in the area, as well as particulate organic carbon (POC) concentrations, changes in standing stocks of chlorophyll-α and bacterial production. TEP concentrations ranged from 15.4 to 188 μg GX eq L-1. Their spatial distribution patterns within the euphotic zone displayed significant seasonal variability, which appears to closely reflect the temporal variation of the water column structure, resulting from the encounter and interplay of the Black Sea and Levantine Water masses, and the associated biogeochemical processes. Minimum TEP concentrations during autumn could be likely attributed to a minor quantity of TEP and/or its dissolved precursors exuded by phytoplankton and their enhanced degradation due to their long residence time in the water column. During spring, high TEP production was mediated by actively growing phytoplankton, while during summer a positive link to the intense stratification of the water column and the enhanced bacterial growth within the Black Sea Water layer was observed. The results reported in this study highlight the fact that TEP carbon represents a significant fraction of the POC pool. Moreover, TEP production is critical in promoting particle coagulation rates, playing an important role in carbon cycling/transportation out of the euphotic zone.

  20. NOM and TEP fouling of a forward osmosis (FO) membrane: Foulant identification and cleaning

    KAUST Repository

    Valladares Linares, Rodrigo

    2012-12-01

    The study of forward osmosis (FO) membranes has increased due to the already demonstrated advantages compared to high-energy membrane processes such as reverse osmosis (RO). This research focuses on characterization of the natural organic matter (NOM) fraction causing fouling on the active layer (AL) of a FO membrane in a novel plate and frame module configuration, facing secondary wastewater effluent as a feed solution (FS) and seawater used as a draw solution (DS). In addition, transparent exopolymer particles (TEP) were observed on the support layer (SL) of the membrane in contact with the DS. The NOM fouling layer, after characterizing the water samples and membranes used, was found to be composed of biopolymers and protein-like substances, which adversely affect the flux of water through the FO membrane. However, NOM fouling showed high reversibility, up to 90% when air scouring for 15. min is used as a cleaning technique. The irreversible fouling in this work was found to be 8.2% after chemical cleaning. On the support layer of the membrane, TEP formed clusters clearly identifiable with an optical microscope and a TEP-specific dye. Chemical cleaning with 1% NaOCl for 10. min proved to be the most effective method to remove TEP. © 2012.

  1. Characterisation of transparent exopolymer particles (TEP) produced during algal bloom: A membrane treatment perspective

    KAUST Repository

    Villacorte, Loreen O.

    2013-01-01

    Algal blooms are currently a major concern of the membrane industry as it generates massive concentrations of organic matter (e.g. transparent exopolymer particles [TEP]), which can adversely affect the operation of membrane filtration systems. The goal of this study is to understand the production, composition and membrane rejection of these organic materials using different characterisation techniques. Two common species of bloom-forming freshwater and marine algae were cultivated in batch cultures for 30days and the productions of TEP and other organic matter were monitored at different growth phases. TEP production of the marine diatom, Chaetoceros affinis, produced 6-9 times more TEP than the freshwater blue-green algae, Microcystis. The organic substances produced by both algal species were dominated by biopolymeric substances such as polysaccharides (45-64%) and proteins (2-17%) while the remaining fraction comprises of low molecular weight refractory (humic-like) and/ or biogenic organic substances. MF/UF membranes mainly rejected the biopolymers but not the low molecular weight organic materials. MF membranes (0.1-0.4 lm) rejected 42-56% of biopolymers, while UF membranes (10-100 kDa) rejected 65-95% of these materials. Further analysis of rejected organic materials on the surface of the membranes revealed that polysac-charides and proteins are likely responsible for the fouling of MF/UF systems during an algal bloom situation. © 2013 Desalination Publications.

  2. Mastery learning simulation-based curriculum for laparoscopic TEP inguinal hernia repair.

    Science.gov (United States)

    Zendejas, Benjamin; Cook, David A; Hernández-Irizarry, Roberto; Huebner, Marianne; Farley, David R

    2012-01-01

    The laparoscopic totally extraperitoneal (TEP) inguinal herniorrhaphy requires 250 repairs to master. Simulation training could potentially accelerate this process. We describe the development, evaluation and implementation of a TEP mastery learning curriculum. We developed a 2-stage curriculum comprising online knowledge modules and skills practice on a simulator (the Guildford-MATTU TEP trainer; Limbs & Things, Ltd, Bristol, UK). Learners demonstrated mastery at each stage before advancing. The knowledge endpoint was a multiple-choice test. The skills endpoint was procedure time, as established by timing 5 experienced staff surgeons. Participants were proctored individually, receiving personalized feedback after each attempt until mastery time was achieved. The times to perform a simulated repair, number of attempts, and training time to reach mastery were compared between groups. The mastery time was established at 2 minutes. Nine medical students, 36 general surgery residents (PGY 1-5), and 3 surgery fellows participated as learners. All learners achieved the knowledge and skills mastery endpoints. For the skill endpoint, participants required a median of 69 minutes (range, 13-193 minutes) and 16 simulated repairs (range, 7-27 repairs). The mean number of attempts and total training time to reach mastery varied by group (p TEP repair under artificial conditions with a performance similar to that of an expert, and are ready to move to the next phase of training in the operating room. Copyright © 2012 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  3. TEP or TAPP for recurrent inguinal hernia repair-register-based comparison of the outcome.

    Science.gov (United States)

    Köckerling, F; Bittner, R; Kuthe, A; Hukauf, M; Mayer, F; Fortelny, R; Schug-Pass, C

    2017-10-01

    The guidelines of the international hernia societies recommend laparo-endoscopic inguinal hernia repair for recurrent hernias after open primary repair. To date, no randomized trials have been conducted to compare the TEP vs TAPP outcome for recurrent inguinal hernia repair. A Swiss registry study identified only minor differences between the two techniques, thus suggesting the equivalence of the two procedures. Between September 1, 2009 and August 31, 2013 data were entered into the Herniamed Registry on a total of 2246 patients with recurrent inguinal hernia repair following previous open primary operation in either TAPP (n = 1,464) or TEP technique (n = 782). Univariable and multivariable analysis did not find any significant difference between TEP and TAPP with regard to the intraoperative complications, complication-related reoperations, re-recurrences, pain at rest, pain on exertion, or chronic pain requiring treatment. The only difference identified was a significantly higher postoperative seroma rate after TAPP, which was influenced by the surgical technique, previous open primary operation and EHS-classification medial and responded to conservative treatment. TEP and TAPP are equivalent surgical techniques for recurrent inguinal hernia repair following previous open primary operation. The choice of technique should be tailored to the surgeon's expertise.

  4. Laparoscopic TEP repair of inguinal hernia does not alter testicular perfusion.

    Science.gov (United States)

    Lal, P; Bansal, B; Sharma, R; Pradhan, G

    2016-06-01

    The effect of laparoscopic TEP repair on testicular perfusion is unclear. The procedure entails dissection of testicular blood vessels off the hernial sac and incorporation of a prosthetic mesh. This carries at minimum, a theoretical risk of compromise in testicular blood supply, which in turn may affect fertility. Our study aims to establish if any alteration in testicular perfusion occurs in very early (24 h), early (1 week) or late postoperative period (3 months) after laparoscopic TEP repair in the Indian population. In our prospective trial, 20 patients underwent unilateral and 8 underwent bilateral laparoscopic TEP hernia repairs using standard technique by experienced surgeons. Flow parameters of testicular, capsular and intratesticular artery were noted using color Doppler ultrasound preoperatively and postoperatively and the postoperative resistive indexes of operated side (n = 36) were compared with preoperative values. Additionally, for unilateral repairs, flow parameters on operated side were compared with the non-operated side. No statistically significant difference was noticed in the resistive index of the arteries upon comparing these postoperative with preoperative values. For unilateral repairs, the flow parameters of the operated side were comparable with that of non-operated side (i.e. p > 0.05). Laparoscopic TEP performed by experienced surgeons does not alter testicular flow dynamics in early or late postoperative period.

  5. The Surgical Treatment of Inguinal Hernia Using the Laparoscopic Totally Extra-Peritoneal (TEP) Technique.

    Science.gov (United States)

    Mihăileanu, Florin; Chiorescu, Stefan; Grad, Ovidiu; Negrea, Voicu; Silaghi, Horatiu; Mironiuc, Aurel

    2015-01-01

    The surgical repair of inguinal hernia represents one of the most frequent procedures used in general surgery. The new surgical techniques are simpler, with a lower morbidity and recurrence of less than 2%. The laparoscopic totally extra-peritoneal (TEP) technique is contraindicated in complicated hernias (occlusion, incarceration) and in voluminous inguino-scrotal hernias. The evaluation of the TEP technique, of the risk factors and of the postoperative results on the group of patients who have undergone surgery in the Surgical Clinic 2 Cluj Napoca. The study is prospective, on a group of 40 patients operated with the TEP technique in the Surgical Clinic 2 during the period May 2013 - July 2014. The following have been assessed: the demographic data, the risk factors, the immediate complications, the recurrence of the hernias. The average duration of hospitalization was 6.79 days. The intraoperative incidents were: 7 minimal peritoneal lesions with pneumoperitoneum and a hemorrhagic lesion of the epigastric vessels repaired endoscopically by the clipping of the lesion. There were 2 recurrences, 24 hours and 1 year after surgery, solved by the Lichtenstein technique. After 30 interventions, the average duration of the surgery was of 64 minutes, being longer in the case of bilateral hernias and being influenced by the team's learning curve. The TEP technique is a safe option followed by a low rate of complications, a low recurrence rate and low intensity postoperative pain.

  6. Effects of totally extraperitoneal (TEP) and Lichtenstein hernia repair on testicular blood flow and volume.

    Science.gov (United States)

    Gürbulak, Esin Kabul; Gürbulak, Bünyamin; Akgün, İsmail Ethem; Özel, Alper; Akan, Deniz; Ömeroğlu, Sinan; Öz, Ayhan; Mihmanlı, Mehmet; Bektaş, Hasan

    2015-11-01

    Laparoscopic totally extraperitoneal hernia repair (TEP) has been compared with the open technique in several studies in terms of technical properties and perioperative outcomes. There are few studies that compare the long-term effects of each technique on testicular structure and function on the side of the hernia repair. The objective of this study is to investigate the effects at 6 months of the TEP and the Lichtenstein technique on testicular volume and arterial flow by the use of Doppler ultrasonography. A total of 148 men with a unilateral hernia were randomized prospectively to undergo TEP or Lichtenstein repair. In both groups, unilateral resistive indices, pulsatile indices of capsular and intratesticular artery flow, and testicular volume (in milliliters) were measured preoperatively and 6 months postoperatively by the use of grayscale and color Doppler ultrasonography (CDUS). The primary outcomes of the study were postoperative findings from history, physical examination, and CDUS measurements at 6 months postoperatively. Demographics, clinical and operative data, CDUS measurements, and recurrence patterns were analyzed. Of 148 procedures, 134 cases consisting of 64 TEP and 70 Lichtenstein repairs were evaluated. Pre- and postoperative CDUS findings, rates of complications, and recurrence in both groups did not show any difference. Operative time was greater with a Lichtenstein repair (36 vs 30 minutes; P = .01). Complications and recurrence rates and effects on testicular perfusion and testicular volume in both laparoscopic and open techniques are similar, whereas the laparoscopic approach has shorter operative time than open hernia repair. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Pain after totally extraperitoneal (TEP) hernia repair might fade out within a year

    NARCIS (Netherlands)

    Burgmans, J. P J; Schouten, N.; Clevers, G. J.; Verleisdonk, E. J M M; Davids, P. H P; Voorbrood, C. E H; Simmermacher, R. K J|info:eu-repo/dai/nl/119478692; Van Dalen, T.

    2015-01-01

    Background: The incidence of chronic pain after endoscopic hernia repair varies between 1 and 16 %. Studies regarding the course of pain in time after the operation are scarce. Methods: 473 male patients ≥18 years of age, scheduled for totally extraperitoneal (TEP) hernia repair (Prolene® mesh)

  8. Visualization and quantification of transparent exopolymer particles (TEP) in freshwater using an auto-imaging approach.

    Science.gov (United States)

    Thuy, Nguyen Thi; Huang, Chih-Pin; Lin, Jr-Lin

    2017-07-01

    Most water sources are full of microscopic transparent exopolymer particles (TEP), which are currently regarded as a major initiator of biofilm formation. This study developed and applied an auto-imaging FlowCAM-based method for online observation and quantification of TEP in freshwater. Samples from reservoirs in Taiwan with a wide range of water quality were directly used to develop this methodology. Factors that potentially affect the measurement were tested. The results showed that characteristics of the particles measured instantaneously after staining samples with Alcian blue differed significantly from those measured at steady states, as a result of particle aggregation. Compared to traditional microscopic methods, this proposed method provides a simple, rapid, and less labor-intensive analysis with particle morphological conservation and a large number of particle attributes. By overcoming the limitations from the former, this technique would offer routine monitoring of these transparent particles from various freshwater sources and feed water in membrane filtration, hence facilitating the use of TEP as a critical parameter for biofouling investigation in water treatment. Application of the method for Taiwan reservoirs showed a wide variety of morphological forms of TEP and its abundance, up to 25,000 ppm.

  9. Ability of TEP1 in intestinal flora to modulate natural resistance of Anopheles dirus.

    Science.gov (United States)

    Wang, Yanyan; Wang, Ying; Zhang, Jingru; Xu, Wenyue; Zhang, Jian; Huang, Fu Sheng

    2013-08-01

    Blocking transmission of malaria is a reliable way to control and eliminate infection. However, in-depth knowledge of the interaction between Plasmodium and mosquito is needed. Studies suggest that innate immunity is the main mechanism inhibiting development of malaria parasites in the mosquito. Recent studies have found that use of antibiotics that inhibit the mosquito gut flora can reduce the immune response of Anopheles gambiae, thereby contributing to the development of malaria parasites. In our study, we used the non susceptible model of Anopheles dirus-Plasmodium yoelii to explore the effect of Anopheles intestinal flora on the natural resistance of A. dirus to P. yoelii. We found that in mosquitoes infected with Plasmodium, the intestinal flora can regulate expression of thioester-containing protein (TEP1) via an RNAi gene-silencing approach. Our results suggest that in the absence of TEP1, the natural microbiota cannot suppress the development of P. yoelii in A. dirus. This suggests that AdTEP1 plays an important role in the resistance of A. dirus to P. yoelii. The intestinal flora may modulate the development of P. yoelii in A. dirus by regulating TEP1 expression. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Carbon content and C:N ratio of transparent exopolymeric particles (TEP) produced by bubbling exudates of diatoms

    DEFF Research Database (Denmark)

    Mari, Xavier

    1999-01-01

    The carbon content of transparent exopolymeric particles (TEP) was measured in the laboratory in particles produced by bubbling exudates of the diatom Thalassiosira weissflogii, grown under nitrogen non-limited conditions (N:P = 7). The carbon content of these particles (TEP-C) appears to vary...... for dissolved organic carbon in coastal seas. The carbon to nitrogen ratio of TEP was measured from particles formed by bubbling exudates of the diatoms T. weissflogii, Skeletonema costatum, Chaetoceros neogracile and C. affinis. Each of these diatom species was grown under various N:P ratios, from N...

  11. Laparoscopic Total Extraperitoneal (TEP) Inguinal Hernia Repair Using 3-dimensional Mesh Without Mesh Fixation.

    Science.gov (United States)

    Aliyazicioglu, Tolga; Yalti, Tunc; Kabaoglu, Burcak

    2017-08-01

    Approximately one fifth of patients suffer from inguinal pain after laparoscopic total extraperitoneal (TEP) inguinal hernia repair. There is existing literature suggesting that the staples used to fix the mesh can cause postoperative inguinal pain. In this study, we describe our experience with laparoscopic TEP inguinal hernia surgery using 3-dimensional mesh without mesh fixation, in our institution. A total of 300 patients who had undergone laparoscopic TEP inguinal hernia repair with 3-dimensional mesh in VKV American Hospital, Istanbul from November 2006 to November 2015 were studied retrospectively. Using the hospital's electronic archive, we studied patients' selected parameters, which are demographic features (age, sex), body mass index, hernia locations and types, duration of operations, preoperative and postoperative complications, duration of hospital stays, cost of surgery, need for analgesics, time elapsed until returning to daily activities and work. A total of 300 patients underwent laparoscopic TEP hernia repair of 437 inguinal hernias from November 2006 to November 2015. Of the 185 patients, 140 were symptomatic. Mean duration of follow-up was 48 months (range, 6 to 104 mo). The mean duration of surgery was 55 minutes for bilateral hernia repair, and 38 minutes for unilateral hernia repair. The mean duration of hospital stay was 0.9 day. There was no conversion to open surgery. In none of the cases the mesh was fixated with either staples or fibrin glue. Six patients (2%) developed seroma that were treated conservatively. One patient had inguinal hernia recurrence. One patient had preperitoneal hematoma. One patient operated due to indirect right-sided hernia developed right-sided hydrocele. One patient had wound dehiscence at the umbilical port entry site. Chronic pain developed postoperatively in 1 patient. Ileus developed in 1 patient. Laparoscopic TEP inguinal repair with 3-dimensional mesh without mesh fixation can be performed as safe as

  12. Bilateral totally extraperitoneal (TEP) repair of the ultrasound-diagnosed asymptomatic contralateral inguinal hernia.

    Science.gov (United States)

    Malouf, Phillip A; Descallar, Joseph; Berney, Christophe R

    2018-02-01

    The aim of this series is to determine the clinical utility of routine ultrasound (US) of the contralateral, clinically normal groin when a unilateral inguinal hernia is referred for hernia repair-specifically assessing the morbidity and short-term change in quality-of-life (QoL) due to repair of this occult contralateral hernia when also repairing the symptomatic side. TEP inguinal hernia repair affords the opportunity to repair any groin hernia through the same small incisions. US detects 96.6% of groin hernias with 84.4% specificity. 234 consecutive male patients with clinically unilateral and clinically bilateral hernia were enrolled; those with a clinically unilateral hernia were sent for groin US and if positive, a bilateral TEP groin hernia repair was performed (USBH). If negative, a unilateral TEP groin hernia repair was performed (UNIH). Carolina's comfort scales (CCS) and visual analogue scores (VAS) were recorded at 2 and 6 weeks postoperatively, while a modified CCS (MCCS) was recorded for all patients preoperatively. Bilateral TEP repair resulted in higher VAS scores than unilateral repair at 2 weeks but not 6 weeks. CCS were worse in the USBH group than UNIH group at 2 weeks but were similar by 6 weeks. Complications' rates were similar amongst all 3 groups. Factors contributing to worse scores were: smaller hernia, complications, worse preoperative MCCS results, recurrent hernia and bilateral rather than unilateral repair. Bilateral TEP for the clinically unilateral groin hernia with an occult contralateral groin hernia can be performed without increased morbidity, accepting a minor and very temporary impairment of QoL.

  13. Which is the best laparoscopic approach for inguinal hernia repair: TEP or TAPP? A systematic review of the literature with a network meta-analysis.

    Science.gov (United States)

    Bracale, Umberto; Melillo, Paolo; Pignata, Giusto; Di Salvo, Enrico; Rovani, Marcella; Merola, Giovanni; Pecchia, Leandro

    2012-12-01

    Totally extraperitoneal (TEP) repair and transabdominal preperitoneal (TAPP) repair are the most used laparoscopic techniques for inguinal hernia treatment. However, many studies have shown that laparoscopic hernia repair compared with open hernia repair (OHR) may offer less pain and shorter convalescence. Few studies compared the clinical efficacy between TEP and TAPP technique. The purpose of this study is to provide a comparison between TEP and TAPP for inguinal hernia repair to show the best approach. We performed an indirect comparison between TEP and TAPP techniques by considering only randomized, controlled trials comparing TEP with OHR and TAPP with OHR in a network meta-analysis. We considered the following outcomes: operative time, postoperative complications, hospital stay, postoperative pain, time to return to work, and recurrences. The two techniques improved some short outcomes (such as time to return to work) with respect to OHR. In the network meta-analysis, TEP and TAPP were equivalent for operative time, postoperative complications, postoperative pain, time to return to work, and recurrences, whereas TAPP was associated with a slightly longer hospital stay compared with TEP. TEP and TAPP improved clinical outcomes compared with OHR, but the network meta-analysis showed that TEP and TAPP efficacy is equivalent. TAPP was associated with a slightly longer hospital stay compared with TEP.

  14. FDG-PET response-adapted therapy

    DEFF Research Database (Denmark)

    Hutchings, Martin

    2014-01-01

    Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is the most accurate tool for staging, treatment monitoring, and response evaluation in Hodgkin lymphoma (HL). Early determination of treatment sensitivity by FDG-PET is the best tool to guide individualized......, response-adapted treatment. Several ongoing or recently completed trials have investigated the use of FDG-PET/CT for early response-adapted HL therapy. The results are encouraging, but the data are immature, and PET response-adapted HL therapy is discouraged outside the setting of clinical trials. PET...

  15. On the interest of PET with {sup 18}F-FDG in the management of cancer of unknown primary (CUP); Impact de la tomographie par emission de positons au {sup 18}fluorodesoxyglucose dans la prise en charge des cancers de primitif inconnu

    Energy Technology Data Exchange (ETDEWEB)

    Bruna, C.; Journo, A.; Netter, F.; Olivier, P.; Karcher, G. [Hopital de Brabois, Service de Medecine Nucleaire, 54 - Nancy (France); Kaminsky, M.C. [Centre Alexis-Vautrin, Service de Cancerologie, 54 - Nancy (France); Dolivet, G. [Centre Alexis-Vautrin, Service de chirurgie ORL, 54 - Nancy (France)

    2007-05-15

    Aim and method: This retrospective study, performed on 37 patients. gave us the opportunity to evaluate the impact of {sup 18}F-FDG PET/CT for cancer of unknown primary (CUP). We first wanted to study the precision of the exam to detect the primary, after a negative check-up, for the extension of the disease, and to judge the impact of the results on management and survival of those patients. Result: The PET/CT led to the detection of the primary for 14 patients out of 37, after a negative check-up composed of five exams on average. For 10 patients, the exam allows the detection of supplementary metastases. The management was changed after the exam in more than one third of the patients, but without any significant impact on the time of survival of these patients, for whom the prognostic is usually dismal. Conclusion: The {sup 18}F-FDG PET/CT appears a valuable tool for detection of primary. changing the management of many of the patients. These results must be completed by a prospective study, in particular to judge the impact of exam's results on the survival. (authors)

  16. Male infertility after endoscopic Totally Extraperitoneal (Tep) hernia repair (Main): rationale and design of a prospective observational cohort study.

    Science.gov (United States)

    Schouten, Nelleke; van Dalen, Thijs; Smakman, Niels; Elias, Sjoerd G; van de Water, Cees; Spermon, Roan J; Mulder, Laurens Sibinga; Burgmans, Ine P J

    2012-05-21

    To describe the rationale and design of an observational cohort study analyzing the effects of endoscopic Totally Extraperitoneal (TEP) hernia repair on male fertility (MAIN study). The MAIN study is an observational cohort study designed to assess fertility after endoscopic TEP hernia repair. The setting is a high-volume single center hospital, specialized in TEP hernia repair. Male patients of 18-60 years of age, with primary, reducible, bilateral inguinal hernias and no contraindications for endoscopic TEP repair are eligible for inclusion in this study. Patients with an ASA-classification≥III and patients with recurrent and/or scrotal hernias and/or a medical history of pelvic surgery and/or radiotherapy, known fertility problems, diabetes and/or other diseases associated with a risk of fertility problems, will be excluded. The primary outcome is the testicular perfusion before and 6 months after TEP hernia repair (assessed by means of a scrotal ultrasonography). Secondary endpoints are the testicular volume (Ultrasound), semen quality and quantity and the endocrinological status, based on serum levels of the sexual hormones follicle-stimulating hormone (FSH), luteinizing hormone (LSH), testosterone and inhibin B before and 6 months after TEP hernia repair. The use of polypropylene mesh is associated with a strong foreign body reaction which could play a role in chronic groin pain development. Since the mesh in (endoscopic) inguinal hernia repair is placed in close contact to the vas deferens and spermatic vessels, the mesh-induced inflammatory reaction could lead to a dysfunction of these structures. Relevant large and prospective clinical studies on the problem are limited. This study will provide a complete assessment of fertility in male patients who undergo simultaneous bilateral endoscopic TEP hernia repair, by analyzing testicular perfusion and volume, semen quantity and quality and endocrinological status before and 6 months after TEP repair

  17. A rare complication from total extraperitoneal (TEP) laparoscopic inguinal hernia repair: bladder rupture associated with a balloon dissector.

    Science.gov (United States)

    Chow, P-M; Su, Y-R; Chen, Y-S

    2013-12-01

    We report a rare complication of TEP herniorrhaphy. A 47-year-old man underwent TEP inguinal hernia repair. Bladder rupture was noted after balloon dissection. The defect was sutured, and the hernia was repaired under laparoscopy. Cystoscopy showed the site of injury at anterior bladder neck. This is the first report of bladder rupture associated with balloon dissector in a patient with no prior abdominal surgery.

  18. Temperature-induced assembly of semiconductor nanocrystals into fractal architectures and thermoelectric power properties in Au/Ge bilayer films

    Energy Technology Data Exchange (ETDEWEB)

    Li Quanbao; Wang Jian; Jiao Zheng [Shanghai Applied Radiation Institute, Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444 (China); Wu Minghong, E-mail: mhwu@staff.shu.edu.cn [Shanghai Applied Radiation Institute, Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444 (China); Shek, Chan-Hung; Lawrence Wu, C.M.; Lai, Joseph K.L. [Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong (Hong Kong); Chen Zhiwen, E-mail: cnzwchen@yahoo.com.cn [Shanghai Applied Radiation Institute, Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444 (China); Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong (Hong Kong)

    2011-08-15

    Highlights: > Ge fractal architectures were achieved by temperature-induced assembly. > The appearance of fractal architectures influences the thermoelectric power. > But it has little effect on the resistivity. > The values of the superlocalization exponent were within 1.22 {<=} {xi} {<=} 1.29. > It was higher than expected for two-dimension fractal system. - Abstract: Fractal architectures of semiconductor nanocrystals were successfully achieved by temperature-induced assembly of semiconductor nanocrystals in gold/germanium (Au/Ge) bilayer films. New assessment strategies of fractal architectures are of fundamental importance in the development of micro/nano-devices. Temperature-dependent properties including resistivity and thermoelectric power (TEP) of Au/Ge bilayer films with self-similar fractal patterns were investigated in detail. Experimental results indicated that the microstructure of Au film plays an important role in the characteristics of Au/Ge bilayer films after annealing and the crystallization processes of amorphous Ge accompany by fractal formation of Ge nanocrystals via temperature-induced assembly. The appearance of fractal architectures has significantly influence on the TEP but little effect on the resistivity of the annealed bilayer film. By analysis of the data, we found that the values of superlocalization exponent are within 1.22 {<=} {xi} {<=} 1.29, which are higher than expected for two-dimension fractal systems. The results provided possible evidence for the superlocalization on fractal architectures in Au/Ge bilayer films. The TEP measurements are considered a more effective method than the conductivity for investigating superlocalization in a percolating system.

  19. Transparent exopolymer particles (TEP) removal efficiency by a combination of coagulation and ultrafiltration to minimize SWRO membrane fouling.

    Science.gov (United States)

    Li, Sheng; Lee, Shang-Tse; Sinha, Shahnawaz; Leiknes, TorOve; Amy, Gary L; Ghaffour, Noreddine

    2016-10-01

    This study investigated the impact of coagulation on the transformation between colloidal and particulate transparent exopolymer particles (TEP) in seawater; and the effectiveness of a combined pretreatment consisting of coagulation and UF on minimizing TEP fouling of seawater reverse osmosis (SWRO) membranes. Coagulation with ferric chloride at pH 5 substantially transformed colloidal TEP (0.1-0.4) into particulate TEP (>0.4) leading to a better membrane fouling control. Both 50 and 100 kDa molecular weight cut-off (MWCO) UF membranes removed most of particulate and colloidal TEP without the assistance of coagulation, but coagulation is still necessary for better UF fouling control. The improvement of combined SWRO pretreatment with coagulation and 50 kDa UF membranes was not that much significant compared to UF pretreatment with 50 KDa alone. Therefore, the minimal coagulant dosage for seawater containing TEP should be based on the UF fouling control requirements rather than removal efficiency. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Transparent exopolymer particles (TEP) removal efficiency by a combination of coagulation and ultrafiltration to minimize SWRO membrane fouling

    KAUST Repository

    Li, Sheng

    2016-07-02

    This study investigated the impact of coagulation on the transformation between colloidal and particulate transparent exopolymer particles (TEP) in seawater; and the effectiveness of a combined pretreatment consisting of coagulation and UF on minimizing TEP fouling of seawater reverse osmosis (SWRO) membranes. Coagulation with ferric chloride at pH 5 substantially transformed colloidal TEP (0.1–0.4) into particulate TEP (>0.4) leading to a better membrane fouling control. Both 50 and 100 kDa molecular weight cut-off (MWCO) UF membranes removed most of particulate and colloidal TEP without the assistance of coagulation, but coagulation is still necessary for better UF fouling control. The improvement of combined SWRO pretreatment with coagulation and 50 kDa UF membranes was not that much significant compared to UF pretreatment with 50 KDa alone. Therefore, the minimal coagulant dosage for seawater containing TEP should be based on the UF fouling control requirements rather than removal efficiency. © 2016 Elsevier Ltd

  1. Normal cerebral FDG uptake during childhood

    Energy Technology Data Exchange (ETDEWEB)

    London, Kevin [The Children' s Hospital at Westmead, Department of Nuclear Medicine, Sydney, NSW (Australia); University of Sydney, Discipline of Paediatrics and Child Health, Sydney Medical School, Sydney, NSW (Australia); Howman-Giles, Robert [The Children' s Hospital at Westmead, Department of Nuclear Medicine, Sydney, NSW (Australia); University of Sydney, Disciplines of Imaging and Paediatrics and Child Health, Sydney Medical School, Sydney, NSW (Australia)

    2014-04-15

    Current understanding of cerebral FDG uptake during childhood originates from a small number of studies in patients with neurological abnormalities. Our aim was to describe cerebral FDG uptake in a dataset of FDG PET scans in children more likely to represent a normal population. We reviewed cerebral FDG PET scans in children up to 16 years of age with suspected/proven extracranial malignancies and the following exclusions: central nervous system metastases, previous malignancies, previous chemotherapy or radiotherapy, development of cerebral metastases during therapy, neurological conditions, taking antiepileptic medication or medications likely to interfere with cerebral metabolism, and general anaesthesia within 24 h. White matter, basal ganglia, thalamus and the cerebellar cortex were analysed using regional SUV{sub max}, and the cerebral cortex, basal ganglia, thalamus and cerebellum were analysed using a regional relative uptake analysis in comparison to maximal cortical uptake. Scans from 30 patients (age range 11 months to 16 years, mean age 10 years 5 months) were included. All regions showed increasing SUV{sub max} with age. The parietal, occipital, lateral temporal and medial temporal lobes showed lower rates of increasing FDG uptake causing changing patterns of regional FDG uptake during childhood. The cortical regions showing the most intense uptake in early childhood were the parietal and occipital lobes. At approximately 7 years of age these regions had relatively less uptake than the frontal lobes and at approximately 10 years of age these regions had relatively less uptake than the thalamus. Relative FDG uptake in the brain has not reached an adult pattern by 1 year of age, but continues to change up to 16 years of age. The changing pattern is due to different regional rates of increasing cortical FDG uptake, which is less rapid in the parietal, occipital and temporal lobes than in the frontal lobes. (orig.)

  2. FDG PET/CT in bone sarcoidosis.

    Science.gov (United States)

    Grozdic Milojevic, Isidora; Sobic-Saranovic, Dragana; Videnovic-Ivanov, Jelica; Saranovic, Djordjije; Odalovic, Strahinja; Artiko, Vera

    2016-03-29

    Bone sarcoidosis is rare manifestation of disease usually accompanied with pulmonary involvement. Until today, exact prevalence of bone sarcoidosis is not known, since reported prevalence varies widely depending on the studied population and the used diagnostic techniques. To determine the prevalence of bone involvement and distribution pattern in active chronic sarcoidosis by using FDG PET/CT. Between January 2010 and December 2011, 98 patients with chronic sarcoidosis and presence of prolonged symptoms or other findings suggestive of active disease were referred to FDG PET/CT examination. Active disease was found in 82 patients, and they all were screened for presence of bone sarcoidosis on FDG PET/CT. All patients also underwent MDCT and assessment of serum ACE level. Bone sarcoidosis was present in 18/82 patients with active sarcoidosis. FDG uptake in bones was focal in 8 (44.4%), diffuse in 6 (33.3%) and both diffuse and focal in 4 (22.2%) patients. CT indicated bone abnormalities only in 5% patients. Osseous involvement was present in: pelvis (61.1%), vertebrae (44.4%), ribs (27.8%) and bone marrow (16.7%). Some patients had two or more locations of disease. Follow-up FDG PET/CT showed normal findings in two patients, same localization of active disease in four patients and progression of disease in one. In patients with active chronic sarcoidosis 22% of patients had osseous abnormalities on FDG PET/CT that mostly were not detected on CT.

  3. In myotonic dystrophy type 1 reduced FDG-uptake on FDG-PET is most severe in Brodmann area 8

    OpenAIRE

    Renard, Dimitri; Collombier, Laurent; Castelli, Christel; Pouget, Jean-Pierre; Kotzki, Pierre-Olivier; Boudousq, Vincent

    2016-01-01

    Background In myotonic dystrophy type 1 (DM1), only one FDG-PET study used statistical parametric mapping (SPM) showing frontal reduced FDG-uptake. Our aim was to 1) identify the FDG-PET area with the most severe reduced FDG-uptake using SPM8 in a larger group of patients 2) assess potential correlation between CTG-numbers and FDG-PET. Methods FDG-PET was performed in 24 patients and compared to 24 controls. Pearson?s correlation was used to analyse correlation. Results SPM8 revealed Brodmann...

  4. FDG and FDG-labelled leucocyte PET/CT in the imaging of prosthetic joint infection

    Energy Technology Data Exchange (ETDEWEB)

    Aksoy, Sabire Yilmaz; Asa, Sertac; Ozhan, Meftune; Sager, M.S.; Halac, Metin; Kabasakal, Levent; Soenmezoglu, Kerim; Kanmaz, Bedii [University of Istanbul, Department of Nuclear Medicine, Cerrahpasa Medical Faculty, Aksaray, Istanbul (Turkey); Ocak, Meltem [University of Istanbul, Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul (Turkey); Erkan, Melih Engin [Duzce University School of Medicine, Department of Nuclear Medicine, Duzce (Turkey)

    2014-03-15

    The demand for arthroplasty is rapidly growing as a result of the ageing of the population. Although complications such as heterotrophic ossification, fracture and dislocation are relatively rare, differentiating aseptic loosening, the most common complication of arthroplasty from infection, is a major challenge for clinicians. Radionuclide imaging is currently the imaging modality of choice since it is not affected by orthopaedic hardware. Whereas FDG PET/CT imaging has been widely used in periprosthetic infection, it cannot discriminate aseptic from septic inflammation. In this study we aimed to evaluate the role of FDG PET/CT and FDG-labelled leucocyte PET/CT in the diagnosis of periprosthetic infection. Of 54 patients with painful joint arthroplasty who were imaged by FDG PET/CT for diagnosis of periprosthetic infection examined, 46 (36 women, 10 men; mean age 61.04 ± 12.2 years, range 32 - 89 years) with 54 painful joint prostheses (19 hip, 35 knee) with grade 2 (above liver uptake) FDG accumulation on FDG PET/CT were included in the study and these 46 patients also underwent FDG-labelled leucocyte PET/CT. Final diagnoses were made by histopathological-microbiological culture or clinical follow-up. The final diagnosis showed infection in 15 (28 %) and aseptic loosening in 39 (72 %) of the 54 prostheses. FDG PET/CT was found to have a positive predictive value of 28 % (15/54). Since patients with no FDG uptake on FDG PET/CT were excluded from the study, the sensitivity, specificity, negative predictive value and accuracy could not be calculated. The sensitivity, specificity, and positive and negative predictive values of FDG-labelled leucocyte PET/CT were 93.3 % (14/15), 97.4 % (38/39), 93.3 % and 97.4 %, respectively. Since FDG is not specific to infection, the specificity of FDG PET/CT was very low. FDG-labelled leucocyte PET/CT with its high specificity may be a useful method and better than labelled leucocyte scintigraphy in periprosthetic infection

  5. Impairment of sexual activity before and after endoscopic totally extraperitoneal (TEP) hernia repair.

    Science.gov (United States)

    Schouten, N; van Dalen, T; Smakman, N; Clevers, G J; Davids, P H P; Verleisdonk, E J M M; Tekatli, H; Burgmans, J P J

    2012-01-01

    In patients with inguinal hernias, sexual activity may be impaired due to hernia-related pain. Surgical repair may improve these complaints but can also lead to similar symptoms as a long-term complication of the operation. Endoscopic hernia repair is associated with less postoperative pain and earlier return to normal activities, but its effect on pain-related sexual function is unknown. In this study, the incidence and effect of pain related to sexual activity are evaluated before and after endoscopic totally extraperitoneal (TEP) hernia repair. A hospital-based questionnaire study of pain-related sexual dysfunction was conducted in November 2009 in 500 male patients ≥18 years, who underwent TEP repair of a primary hernia between March 2006 and December 2008. The response rate was 77.2%. Pain of any severity during sexual activity was reported by 124 patients (32.1%) preoperatively and 35 patients (9.1%) postoperatively. Only 2.3% of the 262 patients with no history of preoperative pain experienced moderate to severe (VAS 4-10) pain postoperatively. Pain impaired sexual function in 63 patients (16.3%) preoperatively and in 18 patients (4.7%) postoperatively. The majority of patients who reported pain during sexual activity preoperatively (n = 102, 82.3%) had no pain postoperatively. The frequency of moderate to severe painful sexual activity decreased from 21.2% (preoperatively) to 3.4% after TEP repair (P TEP hernia repair. Postoperatively, moderate to severe painful sexual activity occurred in 2.3% of the patients with no history of preoperative complaints.

  6. Bilateral endoscopic totally extraperitoneal (TEP) inguinal hernia repair does not impair male fertility.

    Science.gov (United States)

    Roos, M M; Clevers, G J; Verleisdonk, E J; Davids, P H; van de Water, C; Spermon, R J; Mulder, L S; Burgmans, J P J

    2017-12-01

    Endoscopic totally extraperitoneal (TEP) hernia repair with polypropylene mesh has become a well-established technique. However, since the mesh is placed in close contact with the spermatic cord, mesh-induced inflammation may affect its structures, possibly resulting in impaired fertility. The aim of this observational prospective cohort study was to assess fertility after bilateral endoscopic TEP inguinal hernia repair in male patients. Fifty-seven male patients (22-60 years old) with primary, reducible, bilateral inguinal hernias underwent elective bilateral endoscopic TEP hernia repair with use of polypropylene mesh. The primary outcome was testicular perfusion; secondary outcomes were testicular volume, endocrinological status, and semen quality. All patients were assessed preoperatively and 6 months postoperatively. Follow-up was completed in 44 patients. No statistically significant differences in measurements of testicular blood flow parameters or testicular volume were found. Postoperative LH levels were significantly higher [preoperative median 4.3 IU/L (IQR 3.4-5.3) versus postoperative median 5.0 IU/L (IQR 3.6-6.5), p = 0.03]. Levels of inhibin B were significantly lower postoperatively [preoperative median 139.0 ng/L (IQR 106.5-183.0) versus postoperative median 27.0 ng/L (IQR 88.3-170.9), p = 0.01]. No significant changes in FSH or testosterone levels were observed. There were no differences in semen quality. Our data suggest that bilateral endoscopic TEP hernia repair with polypropylene mesh does not impair fertility, as no differences in testicular blood flow, testicular volume, or semen quality were observed. Postoperative levels of LH and inhibin B differed significantly from preoperative measurements, yet no clinical relevance could be ascribed to these findings.

  7. Revising the release of fixed carbon in coastal phytoplankton: the role of transparent exopolymer particles (TEP)

    Science.gov (United States)

    Windecker, L.; Brzezinski, M. A.; Wear, E.; Carlson, C. A.; Passow, U.

    2016-02-01

    Historically, dissolved organic carbon production by phytoplankton in laboratory cultures has been measured to be 10% or less of total production, yet this percentage becomes more variable and generally higher in the field. Reconciling these differences is challenging, with implications for carbon modeling, carbon sequestration, and microbial loop processes. We modeled how carbon flows in upwelling systems among various carbon pools (particulate, dissolved, respired CO2) by growing three coastal diatom species of varied sizes and life histories under three types of nutrient stress (silicic acid, nitrate or simultaneous silicic acid and nitrate) in simulated upwelling conditions (i.e. batch cultures). We tracked transparent exopolymer particles (TEP) (particulate carbon assumed to form from dissolved precursors) and bacterial production (BP) (bacterial carbon formed from dissolved carbon substrate) in addition to dissolved (DOCp) and particulate (POCp) production. By taking into account the range of conversion factors used to convert these measures to estimates of TEP carbon production and bacterial respiration (BR) from the literature, we found that while traditional estimates of dissolved carbon production relative to total production (i.e. DOCp/(DOCp + POCp)) were consistent with previous studies (5% or less), actual extracellular release (defined here as DOCp + TEP production (TEPp) + BR) relative to total production averaged 40% (Range: 12-70%). This percentage varied most among species, with the type of nutrient stress and growth stage (i.e. exponential, stationary) playing secondary roles. The results imply that that a greater fraction of fixed carbon is excreted by phytoplankton than previously thought with the majority forming TEP.

  8. Laparoscopic totally extraperitoneal (TEP) hernioplasty using two trocars: anatomical landmarks and surgical technique.

    Science.gov (United States)

    Iuamoto, Leandro Ryuchi; Kato, Juliana Mika; Meyer, Alberto; Blanc, Pierre

    2015-01-01

    Among endoscopic hernioplasties, totally extraperitoneal (TEP) and transabdominal preperitoneal (TAPP) approach are widely accepted alternatives to open surgery, both providing less postoperative pain, hospital length of stay and early return to work. Classical TEP technique requires three skin incisions for placement of three trocars in the midline or in triangulation. To describe a technique using only two trocars for laparoscopic total extraperitoneal for inguinal hernia repair. Extraperitoneal access: place two regular trocars on the midline. The 10 mm is inserted into the subcutaneous in horizontal direction after a transverse infra-umbilical incision and then elevated at 60º angle. The 5 mm trocar is inserted at the same level of the pubis with direct vision. Preperitoneal space dissection: introduction 0º optical laparoscope through the infra-umbilical incision for visualization and preperitoneal dissection; insufflation pressure must be below 12 mmHg. Dissection of some anatomical landmarks: pubic bone, arcuate line and inferior epigastric vessels. Exposure of "triangle of pain" and "triangle of doom". Insertion through the 10 mm trocar polypropylene mesh of 10x15 cm to cover the hernia sites. Peritoneal sac and the dorsal edge of the mesh are repositioned in order to avoid bending or mesh displacement. It is also important to remember that the drainage is not necessary. The 2-port TEP required less financial costs than usual because it is not necessary an auxiliary surgeon to perform the technique. Trocars, suturing material and wound dressing were spared in comparison to the classical technique. Besides, there were only two incisions, which provides a better plastic result and less postoperative pain. The TEP technique using two trocars is an alternative technique which improves cosmetic and financial outcomes.

  9. Chronic pain after TEP inguinal hernia repair, does MRI reveal a cause?

    Science.gov (United States)

    Burgmans, J P J; Voorbrood, C E H; Van Dalen, T; Boxhoorn, R N; Clevers, G J; Sanders, F B M; Naafs, D B J; Simmermacher, R K J

    2016-02-01

    Persistent pain is a known side effect after TEP inguinal repair disabling 2-5% of patients. A standardized diagnostic work-up so far is not available. MRI is a diagnostic tool in the work-up of inguinal hernias. In the present study the yield of MRI in evaluating chronic pain after TEP hernia repair is addressed. In our database patients receiving an MRI scan for groin pain lasting more than 3 months after TEP inguinal hernia repair were identified. A checklist with potential pathologic findings was filled out for each groin by two blinded observers. Findings in painful, pain-free and unoperated groins were compared and statistical analysis done based upon their relative incidences. Cohen's kappa coefficients were calculated to determine interobserver agreement. Imaging studies of 53 patients revealed information regarding 106 groins. Fifty-five groins were painful after the initial operation, 12 were pain-free postoperatively and 39 groins were not operated. None of the predefined disorders was observed statistically more often in the patients with painful groins. Only fibrosis appeared more prevalent in patients with chronic pain (P = 0.11). Interobserver agreement was excellent for identifying the mesh (κ = 0.88) and observing bulging or a hernia (κ = 0.74) and was substantial for detecting fibrosis (κ = 0.63). In 40% of the patients, MRI showed a correct mesh position and observed nothing else than minor fibrosis. A wait and see policy resolved complaints in the majority of the patients. In 15 % of the patients, MRI revealed treatable findings explanatory for persisting groin pain. For patients with post-TEP hernia groin pain, MRI is useful to confirm a correct flat mesh position and to identify possible not operation-related causes of groin pain. It is of little help to identify a specific cause of groin repair-related pain.

  10. COTS software decision support models for USPACOM's Theater Engagement Plan (TEP)

    OpenAIRE

    Taylor, John E.

    2000-01-01

    Approved for public release; distribution is unlimited As part of the process of achieving national security objectives, the mission of United States Pacific Command (USPACOM) is to enhance security and promote peaceful development in the Asia region by deterring aggression, responding to crisies and fighting to win. USPACOM's Theater Engagement Plan (TEP) contributes to the accomplishment of this mission by planning, coordinating, and implementing peacetime military activities to shape th...

  11. (18)F-FDG PET imaging of murine atherosclerosis

    DEFF Research Database (Denmark)

    Hag, Anne Mette Fisker; Pedersen, Sune Folke; Christoffersen, Christina

    2012-01-01

    To study whether (18)F-FDG can be used for in vivo imaging of atherogenesis by examining the correlation between (18)F-FDG uptake and gene expression of key molecular markers of atherosclerosis in apoE(-/-) mice....

  12. Transabdominal Preperitoneal (TAPP) Versus Totally Extraperitoneal (TEP) for Laparoscopic Hernia Repair: A Meta-Analysis.

    Science.gov (United States)

    Wei, Feng Xian; Zhang, You Cheng; Han, Wei; Zhang, Yu Long; Shao, Yuan; Ni, Rui

    2015-10-01

    To perform a meta-analysis of randomized controlled trials (RCTs) comparing transabdominal preperitoneal (TAPP) with totally extraperitoneal (TEP) in regards of hernia recurrence, pain scores, operation time, time to return to usual activities, length of hospital stay, and total complications. Online databases including Pubmed, Embase and the Cochrane Library were searched with terms "hernia repair," "totally extraperitoneal (TEP) repair," and "transabdominal preperitoneal (TAPP) repair," as well as the medical subject headings. Relevant RCTs were further analyzed using the methods recommended by the Cochrane Collaboration. A total of 10 RCTs enrolling 1047 patients were included. There was no significant difference in terms of hernia recurrence, pain scores, operation time, time to return to usual activities, hospital stay, total complications, and cost between the 2 groups. Subgroup analysis revealed that pain scores would be affected by many clinical factors, operation time was mainly determined by state and surgeon's experience. On the basis of current evidence, TEP as a modified and more complex laparoscopic procedure than TAPP, did not lead to a significant difference in aspects of clinical outcomes and complications. Therefore, we firstly recommended TAPP for laparoscopic hernia repair, especially for nonexpert surgeons. Further choices would be made according to the specific clinical characteristics of patients and surgeons.

  13. The Tolman electronic parameter (TEP) and the metal-metal electronic communication in ditopic NHC complexes.

    Science.gov (United States)

    Gusev, Dmitry G; Peris, Eduardo

    2013-05-28

    Whereas the electronic communication between metals in dimetallic organometallic compounds is often assessed through cyclic voltammetric measurements, we have found that the variations in the Tolman electronic parameter (TEP) can also be an alternative and effective way of determining this type of interaction. The TEP values of several (CO)3Ni-NHC-X systems with five different ditopic NHC ligand systems [triazolyldiylidene (A), bis(imidazolylidene) (B), benzobis(imidazolylidene) (C), cyclopenta[f,g]acenaphthylenebis(imidazolylidene) (D) and bis(imidazolidinylidene) (F)] were determined by means of DFT calculations. Based on these values, the electron-withdrawing character of the X metal fragments employed in this study was found to increase in the order IrCp(CO) → RhCl(COD) → Ni(CO)3 → Cr(CO)5 → RhCl(CO)2. We found that the degree of electronic interaction through the ditopic NHC ligands is the strongest in A, followed by B and F, while being weak in B and C. The TEP values and the quantitative analysis of the upper molecular orbitals of A and F and their (CO)3Ni-NHC-Ni(CO)3 complexes strongly suggest that the principal electronic interaction between the metal centres of the M-NHC-M' complexes is of σ-type, via the delocalized HOMO and HOMO - 1 orbitals of the NHC ligands.

  14. Athletes with inguinal disruption benefit from endoscopic totally extraperitoneal (TEP) repair.

    Science.gov (United States)

    Roos, M M; Bakker, W J; Goedhart, E A; Verleisdonk, E J M M; Clevers, G J; Voorbrood, C E H; Sanders, F B M; Naafs, D B; Burgmans, J P J

    2018-01-30

    Inguinal disruption, a common condition in athletes, is a diagnostic and therapeutic challenge. The aim of this study was to evaluate the effect of endoscopic totally extraperitoneal (TEP) repair in athletes with inguinal disruption, selected through a multidisciplinary, systematic work-up. An observational, prospective cohort study was conducted in 32 athletes with inguinal disruption. Athletes were assessed by a sports medicine physician, radiologist and hernia surgeon and underwent subsequent endoscopic TEP repair with placement of polypropylene mesh. The primary outcome was pain reduction during exercise on the numeric rating scale (NRS) 3 months postoperatively. Secondary outcomes were sports resumption, physical functioning and long-term pain intensity. Patients were assessed preoperatively, 3 months postoperatively and after a median follow-up of 19 months. Follow-up was completed in 30 patients (94%). The median pain score decreased from 8 [interquartile range (IQR) 7-8] preoperatively to 2 (IQR 0-5) 3 months postoperatively (p TEP repair.

  15. Exploiting Earth observation data pools for urban analysis: the TEP URBAN project

    Science.gov (United States)

    Heldens, W.; Esch, T.; Asamer, H.; Boettcher, M.; Brito, F.; Hirner, A.; Marconcini, M.; Mathot, E.; Metz, A.; Permana, H.; Zeidler, J.; Balhar, J.; Soukop, T.; Stankek, F.

    2017-10-01

    Large amounts of Earth observation (EO) data have been collected to date, to increase even more rapidly with the upcoming Sentinel data. All this data contains unprecedented information, yet it is hard to retrieve, especially for nonremote sensing specialists. As we live in an urban era, with more than 50% of the world population living in cities, urban studies can especially benefit from the EO data. Information is needed for sustainable development of cities, for the understanding of urban growth patterns or for studying the threats of natural hazards or climate change. Bridging this gap between the technology-driven EO sector and the information needs of environmental science, planning, and policy is the driver behind the TEP-Urban project. Modern information technology functionalities and services are tested and implemented in the Urban Thematic Exploitation Platform (U-TEP). The platform enables interested users to easily exploit and generate thematic information on the status and development of the environment based on EO data and technologies. The beta version of the web platform contains value added basic earth observation data, global thematic data sets, and tools to derive user specific indicators and metrics. The code is open source and the architecture of the platform allows adding of new data sets and tools. These functionalities and concepts support the four basic use scenarios of the U-TEP platform: explore existing thematic content; task individual on-demand analyses; develop, deploy and offer your own content or application; and, learn more about innovative data sets and methods.

  16. TEP versus Lichtenstein: Which technique is better for the repair of primary unilateral inguinal hernias in men?

    Science.gov (United States)

    Köckerling, F; Stechemesser, B; Hukauf, M; Kuthe, A; Schug-Pass, C

    2016-08-01

    In the update of the guidelines of the European Hernia Society, open Lichtenstein and endoscopic techniques continue to be recommended as the surgical technique of choice for repair of unilateral primary inguinal hernias in men despite the fact that a meta-analysis had identified a higher recurrence rate for TEP compared with Lichtenstein operation. The Guidelines Group had taken that decision because one surgeon in one of the randomized controlled trials included in the meta-analysis had had a very high recurrence rate. Therefore, this study based on registry data now compares the outcome of TEP versus Lichtenstein repair. The analysis of the Herniamed Registry compares the prospective data collected for male patients undergoing primary unilateral inguinal hernia repair using either TEP or open Lichtenstein repair. Inclusion criteria were minimum age of 16 years, male patient, primary unilateral inguinal hernia, elective operation, and availability of data on 1-year follow-up. In total, 17,388 patients were enrolled between September 1, 2009, and August 31, 2013. Of these patients, 10,555 (60.70 %) had a Lichtenstein repair and 6833 (39.30 %) a TEP repair. On multivariable analysis, the surgical technique was not found to have had any significant effect on the recurrence rate (p = 0.146) or on the chronic pain rate (p = 0.560). Nor did the complication-related reoperation rates differ significantly between the two techniques (p = 0.084). But TEP was found to have benefits as regards the postoperative complication rate (p TEP and Lichtenstein technique. TEP was found to have benefits compared with Lichtenstein repair as regards the postoperative complication rates, pain at rest, and pain on exertion.

  17. Laparoscopic inguinal hernia repair: transabdominal preperitoneal (TAPP) versus totally extraperitoneal (TEP) approach: a prospective randomized controlled trial.

    Science.gov (United States)

    Krishna, Asuri; Misra, M C; Bansal, Virinder Kumar; Kumar, Subodh; Rajeshwari, S; Chabra, Anjolie

    2012-03-01

    Minimal access approaches to inguinal hernia repair have added to the ongoing debate over the "best groin hernia repair." The present prospective randomized controlled trial was done to compare the totally extraperitoneal (TEP) and transabdominal preperitoneal (TAPP) techniques of laparoscopic inguinal hernia repair. The present prospective randomized study was conducted between May 2007 and March, 2009 and included 100 patients suffering from uncomplicated primary groin hernia. Patients were randomized into group I (TEP) and group II (TAPP). Intraoperative variables and postoperative pain scores were recorded in a prestructured form. One hundred patients were included in the study (TEP, 53; TAPP, 47). Both groups were comparable in terms of demographic profile and hernia characteristics. The average operative time was higher in the TAPP group (p = 0.209). The pain scores at 1 h and 24 h after surgery and at 3-month follow-up were significantly higher in the TAPP group (p TEP group, 37.8% of patients had seroma compared to 18.3% in the TAPP group (p = 0.021). However, there was a higher incidence of scrotal edema in the TAPP group (16 vs. 9, p = 0.009). The wound infection rates were equal (2% vs. 3%). There has been no recurrence in either group during the follow-up period of 44 months. Overall, the patients were more satisfied with TEP rather than TAPP (p TEP had a significant advantage over TAPP for significantly reduced postoperative pain up to 3 months, which resulted in a better patient satisfaction score. The other intraoperative complications, postoperative complications, and cost were similar in both groups. In terms of results, both repair techniques seemed equally effective, but TEP had an edge over TAPP.

  18. FDG-PET in the clinical management of Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Hutchings, Martin; Eigtved, Annika I; Specht, Lena

    2004-01-01

    ). FDG-PET has within recent years become the most important nuclear medicine imaging modality in the management of lymphoma. This review summarizes the data published so far concerning the value of FDG-PET in staging, treatment monitoring, therapy planning, and follow-up of Hodgkin lymphoma (HL). FDG...

  19. Limitations of FDG-PET and FDG-PET with computed tomography for detecting synchronous cancer in pharyngeal cancer.

    Science.gov (United States)

    Suzuki, Hidenori; Hasegawa, Yasuhisa; Terada, Akihiro; Ogawa, Tetsuya; Hyodo, Ikuo; Suzuki, Masahiro; Nakashima, Tsutomu; Tamaki, Tsuneo; Nishio, Masami

    2008-11-01

    To analyze the ability of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and the fusion of FDG-PET with computed tomography (FDG-PET/CT) to detect synchronous upper gastrointestinal tract (UGI) cancer in newly diagnosed pharyngeal squamous cell carcinoma (SCC). Synchronous UGI cancer is a significant problem in treating pharyngeal SCC, particularly for Japanese populations reported to be at high risk. Good results have been reported from the use of FDG-PET and FDG-PET/CT in staging head and neck SCC (HNSCC). An additional advantage is that both techniques are expected to prove useful in detecting synchronous cancer. Retrospective analysis of medical records. Aichi Cancer Center, Nagoya, Japan. Forty-three Japanese patients with pharyngeal SCC were assessed for the ability of FDG-PET and FDG-PET/CT to detect synchronous UGI cancer via a comparison with UGI Lugol chromoendoscopy. The patients had undergone 17 FDG-PET and 26 FDG-PET/CT scans before treatment. Sensitivity of FDG-PET and FDG-PET/CT to detect synchronous UGI cancer. Pathologically, 6 patients with esophageal SCC (14%) and 4 with stomach adenocarcinoma (9%) were diagnosed on the basis of suspect lesions detected by UGI Lugol chromoendoscopy. One patient was found to have stage T2 esophageal cancer by FDG-PET/CT, but no patients had UGI cancer. The sensitivity of detecting T1 UGI cancer by FDG-PET and FDG-PET/CT was 0%. The choice of diagnostic technique must be based on the site and histologic characteristics of the synchronous tumor. Although FDG-PET and FDG-PET/CT are still the preferred techniques for staging HNSCC, neither replaces Lugol chromoendoscopy for detecting synchronous UGI cancer in high-risk populations.

  20. TAPP or TEP for Recurrent Inguinal Hernia? Population-Based Analysis of Prospective Data on 1309 Patients Undergoing Endoscopic Repair for Recurrent Inguinal Hernia.

    Science.gov (United States)

    Gass, M; Scheiwiller, A; Sykora, M; Metzger, J

    2016-10-01

    Whether total extraperitoneal inguinal hernia repair (TEP) is associated with worse outcomes compared to transabdominal preperitoneal inguinal hernia repair (TAPP) for the treatment of recurrent inguinal hernia continues to be a matter of debate. The objective of this large cohort study is to compare complications, conversion rates and postoperative length of hospital stay between patients undergoing TEP or TAPP for unilateral recurrent inguinal hernia repair. Based on prospective data of the Swiss Association of Laparoscopic and Thoracoscopic Surgery, all patients who underwent elective TEP or TAPP for unilateral recurrent inguinal hernia between 1995 and 2006 were included. The following outcomes were compared: conversion rates, intraoperative complications, surgical postoperative complications and duration of operation. Data on 1309 patients undergoing TEP (n = 1022) and TAPP (n = 287) for recurrent inguinal hernia were prospectively collected. Average age, BMI and ASA score were similar in both groups. Patients undergoing TEP had a significantly increased rate of intraoperative complications (TEP 6.3 % vs. TAPP 2.8 %, p = 0.0225). Duration of operation was longer for patients undergoing TEP (TEP 80.3 vs. TAPP 73.0 min, p TEP 2.6 vs. TAPP 3.1 day, p = 0.0145). Surgical postoperative complications (TEP 3.52 % vs. TAPP 2.09 %, p = 0.2239), general postoperative complications (TEP 1.47 % vs. TAPP 0.7 %, p = 0.3081) and conversion rates (TEP 2.15 % vs. TAPP 1.39 %, p = 0.4155) were not significantly different. This study is the first population-based analysis comparing outcomes of patients with recurrent inguinal hernia undergoing TEP versus TAPP in a prospective cohort of over 1300 patients. Intraoperative complications were significantly higher in patients undergoing TEP. The TEP technique was associated with longer operating times, but a shorter postoperative length of hospital stay. Nonetheless, the absolute outcome differences are small

  1. Horizontal and Vertical Distributions of Transparent Exopolymer Particles (TEP) in the NW Mediterranean Sea Are Linked to Chlorophyll a and O2 Variability.

    Science.gov (United States)

    Ortega-Retuerta, Eva; Sala, Maria M; Borrull, Encarna; Mestre, Mireia; Aparicio, Fran L; Gallisai, Rachele; Antequera, Carolina; Marrasé, Cèlia; Peters, Francesc; Simó, Rafel; Gasol, Josep M

    2016-01-01

    Transparent Exopolymer Particles (TEP) are relevant in particle and carbon fluxes in the ocean, and have economic impact in the desalination industry affecting reverse osmosis membrane fouling. However, general models of their occurrence and dynamics are not yet possible because of the poorly known co-variations with other physical and biological variables. Here, we describe TEP distributions in the NW Mediterranean Sea during late spring 2012, along perpendicular and parallel transects to the Catalan coast. The stations in the parallel transect were sampled at the surface, while the stations in the perpendicular transect were sampled from the surface to the bathypelagic, including the bottom nepheloid layers. We also followed the short-term TEP dynamics along a 2-day cycle in offshore waters. TEP concentrations in the area ranged from 4.9 to 122.8 and averaged 31.4 ± 12.0 μg XG eq L-1. The distribution of TEP measured in transects parallel to the Catalan Coast correlated those of chlorophyll a (Chla) in May but not in June, when higher TEP-values with respect to Chla were observed. TEP horizontal variability in epipelagic waters from the coast to the open sea also correlated to that of Chla, O2 (that we interpret as a proxy of primary production) and bacterial production (BP). In contrast, the TEP vertical distributions in epipelagic waters were uncoupled from those of Chla, as TEP maxima were located above the deep chlorophyll maxima. The vertical distribution of TEP in the epipelagic zone was correlated with O2 and BP, suggesting combined phytoplankton (through primary production) and bacterial (through carbon reprocessing) TEP sources. However, no clear temporal patterns arose during the 2-day cycle. In meso- and bathypelagic waters, where phytoplanktonic sources are minor, TEP concentrations (10.1 ± 4.3 μg XG eq l-1) were half those in the epipelagic, but we observed relative TEP increments coinciding with the presence of nepheloid layers. These TEP

  2. Bilateral and Unilateral Total Extraperitoneal Inguinal Hernia Repair (TEP) have Equivalent Early Outcomes: Analysis of 9395 Cases.

    Science.gov (United States)

    Köckerling, F; Schug-Pass, C; Adolf, D; Keller, T; Kuthe, A

    2015-08-01

    To date, no randomized controlled trials have been carried out to compare the perioperative outcome of unilateral and bilateral inguinal hernia repair using an endoscopic technique. In a Swiss registry study comparing unilateral with bilateral inguinal hernias, no further details were given regarding the nature of the intra- and postoperative complications. In addition, some authors have raised the issue of prophylactic repair of a clinically healthy other groin side. In the Herniamed Registry, in total 9395 patients with a TEP were enrolled. These comprised 6700 patients with unilateral (71.31%) and 2695 patients (28.69%) with bilateral inguinal hernia repair. The outcome variables, analyzed in a multivariable model, were the intra- and postoperative as well as general complication rates, reoperation rate, duration of operation, and length of hospital stay. While no significant difference was found in the overall number of intraoperative complications between the unilateral and bilateral group (p=0.310), a significantly higher number of urinary bladder injuries in the bilateral TEP operation of 0.28% compared with 0.04% for unilateral TEP (p=0,008) were noted. The greater probability of reoperation (0.82% for unilateral vs. 1.78% for bilateral TEP; pTEP which that warrants attention. Based on these results, prophylactic operation of the healthy other groin should not be recommended.

  3. Has Shouldice Repair in a Selected Group of Patients with Inguinal Hernia Comparable Results to Lichtenstein, TEP and TAPP Techniques?

    Science.gov (United States)

    Köckerling, F; Koch, A; Adolf, D; Keller, T; Lorenz, R; Fortelny, R H; Schug-Pass, C

    2018-01-03

    In the new international guidelines only the mesh-based Lichtenstein, TEP and TAPP techniques are recommended. This present analysis of data from the Herniamed Registry compares the outcome for Shouldice versus Lichtenstein, TEP and TAPP. Propensity score matching analyses were performed to obtain homogeneous comparison groups for Shouldice versus Lichtenstein (n = 2115/2608; 81.1%), Shouldice versus TEP (n = 2225/2608; 85.3%) and Shouldice versus TAPP (2400/2608; 92.0%). The most important characteristics of the Shouldice patient collective were younger patients with a mean age of 40 years, a large proportion of women of 30%, a mean BMI value of 24 and a proportion of defect sizes up to 3 cm of over 85%. For this selected patient collective, propensity score matched-pair analysis did not identify any difference in the perioperative and one-year follow-up outcome compared with TAPP, fewer intraoperative (0.5 vs. 1.3%; p = 0.009) but somewhat more postoperative complications (2.3 vs. 1.5%; p = 0.050) compared with TEP and advantages with regard to pain at rest (4.6 vs. 6.1%; p = 0.039) and on exertion (10.0 vs. 13.4%; p TEP and TAPP operations.

  4. Internal plug mesh without fixation in laparoscopic total extraperitoneal (TEP) repair of inguinal hernias: a pilot study.

    Science.gov (United States)

    Choi, Yoon Young; Kim, Zisun; Hur, Kyung Yul

    2013-06-01

    Mesh fixation is essential in laparoscopic total extraperitoneal (TEP) repair of inguinal hernia; however, fixation sometimes causes post-operative pain. This study investigated a novel method of laparoscopic TEP repair without mesh fixation. This study reviewed data from about two-hundred and forty-one laparoscopic TEP repairs on 219 patients, which were performed between December 2004 and October 2005. There were no statistically significant differences in the recurrence rate, seroma formation, and hospital stay. However, the mean operation time was shorter in the internal plug mesh group than the fixation group (p = 0.009), and post-operative pain only occurred in 4 cases in the internal plug mesh group in comparison to 29 cases in the mesh fixation group (p = 0.014). An internal plug mesh without fixation might reduce post-operative pain after laparoscopic TEP repair of an inguinal hernia. Internal plug mesh without fixation may be an alternative method in laparoscopic TEP repair, especially for those involving indirect hernias.

  5. Electrical aspects of the osmorespiratory compromise: TEP responses to hypoxia in the euryhaline killifish (Fundulus heteroclitus) in freshwater and seawater.

    Science.gov (United States)

    Wood, Chris M; Grosell, Martin

    2015-07-01

    The osmorespiratory compromise, the trade-off between the requirements for respiratory and ionoregulatory homeostasis at the gills, becomes more intense during environmental hypoxia. One aspect that has been previously overlooked is possible change in transepithelial potential (TEP) caused by hypoxia, which will influence branchial ionic fluxes. Using the euryhaline killifish, we show that acute hypoxia reduces the TEP across the gills by approximately 10 mV in animals acclimated to both freshwater (FW) and seawater (SW), with a higher PO2  threshold in the former. TEP becomes negative in FW, and less positive in SW. The effects are immediate, stable for at least 3 h, and reverse immediately upon return to normoxia. Hypoxia also blocks the normal increase in TEP that occurs upon transfer from FW to SW, but does not reduce the fall in TEP that occurs with transfer in the opposite direction. These effects may be beneficial in FW but not in SW. © 2015. Published by The Company of Biologists Ltd.

  6. TEP versus TAPP: comparison of the perioperative outcome in 17,587 patients with a primary unilateral inguinal hernia.

    Science.gov (United States)

    Köckerling, F; Bittner, R; Jacob, D A; Seidelmann, L; Keller, T; Adolf, D; Kraft, B; Kuthe, A

    2015-12-01

    More than 20 years since the introduction of TAPP and TEP into clinical routine, there is a lack of clarity due to conflicting comparative data. Therefore, more results from registries are needed. A total of 17,587 patients were enrolled prospectively between September 1, 2009, and April 15, 2013, in the Herniamed registry. Of these patients, 10,887 (61.9%) had a TAPP and 6700 (38.1%) a TEP repair. The dependent variables were intra- and postoperative complication rates, number of reoperations as well as absolute and relative frequencies. The results of unadjusted analyses were verified via multivariable analyses. Multivariable analysis verified the results of unadjusted analysis, indicating that the surgical technique did not have any significant impact, also while taking account of other factors, on occurrence of intraoperative [p = 0.1648; OR = 1.214 (0.923; 1.596)] and general postoperative complications [p = 0.0738; OR = 1.315 (0.974; 1.775)]. Postoperative surgical complications [OR = 2.323 (1.882; 2.866); p TEP and TAPP did not result in any difference in the reoperation rate (TEP 0.82% vs TAPP 0.90%; p = 0.6165). The intraoperative and general postoperative complication rates as well as the reoperation rate for complications show no significant difference between TEP and TAPP. The higher postoperative complication rate for TAPP, which could be managed conservatively, is partly explained by larger defect sizes, more scrotal hernias and older age.

  7. Impact of Mesh Fixation on Chronic Pain in Total Extraperitoneal Inguinal Hernia Repair (TEP): A Nationwide Register-based Study.

    Science.gov (United States)

    Gutlic, Nihad; Rogmark, Peder; Nordin, Pär; Petersson, Ulf; Montgomery, Agneta

    2016-06-01

    Mesh fixation is used to prevent recurrence at the potential risk for chronic pain in TEP. The aim was to compare the impact of permanent fixation (PF) with no fixation (NF)/nonpermanent fixation (NPF) of mesh on chronic pain after TEP repair for primary inguinal hernia. Men, 30 to 75 years old, consecutively registered in the Swedish Hernia Register for a TEP primary repair in 2005 to 2009, were included in a mail survey using SF-36 and the Inguinal Pain Questionnaire (IPQ). Primary endpoint was IPQ question "Did you have pain during past week that could not be ignored." Risk factors for chronic pain and recurrent operations were analyzed. A total of 1110 patients were included (325 PF, 785 NF/NPF) with 7.7% reporting pain at median 33 months follow-up. No difference regarding primary endpoint pain (P TEP procedure for primary inguinal hernia repair in men is associated with a low frequency of chronic pain and recurrent operations, with no difference between permanent fixation and no/nonpermanent fixation of mesh in a nationwide population-based study. TEP without fixation reduces costs and is safe for all patients.

  8. Monitoring of transparent exopolymer particles (TEP) in a membrane bioreactor (MBR) and correlation with other fouling indicators.

    Science.gov (United States)

    de la Torre, T; Lesjean, B; Drews, A; Kraume, M

    2008-01-01

    The occurrence of Transparent Exopolymer Particles (TEP), an acidic fraction of polysaccharides, was monitored for more than six months in the activated sludge of three MBR units, and the relationship between TEP and other fouling indicators was studied. These compounds consist mainly of exopolysaccharides of a sticky nature, a characteristic which makes them a group of interesting substances in processes like sedimentation, flocculation and membrane fouling. The relationship between capillary suction time (CST) and polysaccharides (PS) was linear for the three tested sludges, although the correlation with TEP concentrations was stronger. A slight linear correlation of both TEP and PS was found with the critical flux (CF) measured with a small filtration test cell, which was submerged in the membrane tank to assess the filterability performance of the sludge in situ. However, the correlation CF-PS was clearer. The relationship between TEP, polysaccharides and sludge filterability highlights the potential of this parameter for the monitoring of membrane systems. Copyright (c) IWA Publishing 2008.

  9. FDG PET/CT imaging in canine cancer patients

    DEFF Research Database (Denmark)

    Hansen, Anders Elias; McEvoy, Fintan; Engelholm, Svend Aage

    2011-01-01

    .0, and for sarcomas from 2.0 to 10.6. The FDG SUV of several organs and tissues, including regional brain uptake is reported, to serve as a reference for future FDG PET studies in canine cancer patients. Several potential pitfalls have been recognized in interpretation of FDG PET images of human patients, a number...... and organs in canine cancer patients. FDG PET/CT was performed in 14 dogs including, nine mesenchymal tumors, four carcinomas, and one incompletely excised mast cell tumor. A generally higher FDG uptake was observed in carcinomas relative to sarcomas. Maximum SUV of carcinomas ranged from 7.6 to 27...

  10. Deposition and clearance of inhaled {sup 18}FDG powder in patients with chronic obstructive pulmonary disease

    Energy Technology Data Exchange (ETDEWEB)

    Yanai, M.; Sasaki, H. [Tohoku Univ. School of Medicine, Dept. of Geriatric Medicine, Sendai (Japan); Hatazawa, J.; Ojima, F.; Itoh, M.; Ido, T. [Tohoku Univ. School of Medicine, Cyclotron and Radioisotope Center, Sendai (Japan)

    1998-12-31

    As freon is limited in its use as a generator for aerosol inhalation, powder particles are used as an alternative for inhalation therapy. The pulmonary deposition and clearance of inhaled powder particles was studied by positron emission tomography (PET) in ten patients with chronic obstructive pulmonary disease (COPD) and in five normal controls. The powder, 5 {mu}m in mean diameter, was water soluble and labelled with 2-deoxy-2[{sup 18}F]-fluoro-D-glucose ({sup 18}FDG). Powder inhalation was done with single deep inspiration from residual volume to total lung capacity. The initial deposition ratio in the right or left lung field to total inhaled dose, measured by an anteroposterior rectilinear scan, did not differ between normal and COPD patients. Ratios of radioactivity detected within the central and peripheral regions (the central to peripheral ratio) measured by the PET scan was not significantly different between COPD patients (4.8{+-}2.6, mean{+-}SD) and normals (2.6{+-}0.8, mean{+-}SD). However, the regional powder deposition in peripheral lung fields measured by the PET scan was significantly more uneven in COPD patients than in normal patients. The clearance rate of {sup 18}FDG, defined as the retention ratio of {sup 18}FDG activity to the initially deposited {sup 18}FDG at 60 and 120 min after inhalation, in the trachea, large bronchi or peripheral lung fields measured by tomographic scan showed a wider variation in COPD patients than in normals. To conclude, inhaled powder tended to be deposited more centrally and was distributed more unevenly in the peripheral lung in chronic obstructive pulmonary disease patients than in normals. This could be a limitation of powder inhalation used for therapy in chronic obstructive pulmonary disease patients. (au) 26 refs.

  11. Is unilateral laparoscopic TEP inguinal hernia repair a job half done? The case for bilateral repair.

    Science.gov (United States)

    Pawanindra Lal; Philips, Prejesh; Chander, Jagdish; Ramteke, Vinod K

    2010-07-01

    Bilateral laparoscopic totally extraperitoneal (TEP) repair of unilateral hernia is conspicuous in published literature by its absence. There are no studies or data on the feasibility, advantages or disadvantages of bilateral repair in all cases or in any subset of patients with unilateral primary inguinal hernia. The objective of this study is to investigate the feasibility of bilateral laparoscopic exploration for all unilateral cases followed by laparoscopic TEP in all cases and to compare complications, recurrence rates, postoperative pain, patient satisfaction, and return to work retrospectively with a similar number of age-matched retrospective controls. One hundred fifty TEP operations were performed in 75 patients (group A) prospectively and were compared with 75 unilateral TEP operations (group B) in age-matched controls done previously by the same surgeon. All cases were performed under general anesthesia, and TEP repair was performed using three midline ports. All uncomplicated patients were discharged at 24 h, in keeping with departmental policy. Of 75 patients (group A), 25 (33.3%) were clinically diagnosed with bilateral hernia and the rest (50, 66.66%) with unilateral hernia. The distribution of the 25 bilateral cases was 11 bilateral direct and 14 bilateral indirect inguinal hernias. The distribution of the 75 age-matched controls (group B) was all unilateral hernia, of which 47 were right-sided and 28 were left-sided. There were 23 direct hernias and 52 indirect hernias among the control group. The mean operative time for all 150 cases was 76.66 +/- 15.92 min. The operative time in the control group (unilateral hernias) was 66.16 +/- 12.44 min, whereas the operative time in the test group (bilateral repair) was 87.2 +/- 11.32 min. The operative time in the bilateral group was significantly higher, by 21.04 min or 31.88% (p = 0.000). The operative time in the true unilateral group was 82.45 +/- 9.38 min, whereas the operative time in the former

  12. Positron emission tomography (PET) and pancreatic tumours; Tomographie par emission de positons (TEP) et tumeurs pancreatiques

    Energy Technology Data Exchange (ETDEWEB)

    Montravers, F.; Kerrou, K.; Grahek, D.; Gutman, F.; Beco, V. de; Talbot, J.N. [Hopital Tenon, Service de Medecine, 75 - Paris (France)

    2005-07-15

    Neoplasms of the pancreas may originate front both exocrine and endocrine cells but in 90% of the cases, they correspond to ductal adenocarcinomas. For adenocarcinomas, the major indication of FDG-PET corresponds to the pre-operative staging because unexpected distant metastases can be detected by FDG-PET in about 20 to 40% of the cases, which results in avoidance of unnecessary surgical procedures. FDG PET is also useful in evaluation of the treatment effect, monitoring after the operation and detection of recurrent pancreatic cancers. For the characterisation of the pancreatic tumour, the performance of FDG-PET is sometimes limited due to poor cellularity, hyperglycemia or inflammatory processes. especially for large tumours and is indicated only in cases of doubtful results of CT or MRI. For endocrine pancreatic tumours, FDG-PET is useful only in case of poorly-differentiated and aggressive tumours. F-DOPA PET can he useful, complementary to pentetreotide scintigraphy, in well-differentiated endocrine tumours. (authors)

  13. Esophageal Leiomyoma with intense FDG uptake on {sup 18}F-FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seok Mo; Bae, Sang Kyun [Inje university Medical School, Busan (Korea, Republic of)

    2008-10-15

    A 56 years old woman referred to our hospital with dysphagia and epigastric soreness. Gastroendoscopy revealed huge submucosal tumor with ulceration extending from distal esophagus to lesser curvature of stomach. Subsequent computed tomography (CT) demonstrated soft tissue mass encircling distal esophagus, and 18F-FDG PET/CT demonstrated intense {sup 18}F-FDG accumulation in it. Finally this case was diagnosed as esophageal leiomyoma based on pathologic evaluation of the surgical specimen.

  14. A prospective randomized controlled trial to compare single-port endo-laparoscopic surgery versus conventional TEP inguinal hernia repair.

    Science.gov (United States)

    Wijerathne, Sujith; Agarwal, Narendra; Ramzy, Ahmad; Lomanto, Davide

    2014-11-01

    The success of laparoscopic surgery is due to the less surgical trauma, including less operative pain, complications and better cosmetics. Objective of our study was to compare in two blind randomized groups of patients, the surgical outcome of total extra-peritoneal (TEP) inguinal hernia repair using either single-port or conventional surgical technique. We will report our interim results in the first group of 50 patients. Our study is a prospective, randomized, controlled clinical trial conducted from August 2011 to June 2013. Fifty patients aged between 21 and 80 years undergoing surgery for unilateral inguinal hernia were randomised into two groups: conventional laparoscopic TEP inguinal hernia repair versus single-port TEP repair. Clinical data on patient demographics, surgical technique and findings, postoperative complications and pain scores were collected. Primary endpoint is the postoperative pain while secondary endpoints are recurrence, chronic pain, postoperative hospital stay and complications. Out of the 50 patients, 26 underwent single-port hernia TEP repair and 24 had conventional 3-port TEP hernia repair after randomization. Mean operative time was 51.7 (±13.4) min in the multiport group and 59.3 (±14.9) min in the single-port group, respectively (P = 0.064). Mean hospital stay was 19.7 (±4.8) h in the conventional group and 22.1 (±4.5) h in the single-port group (P = 0.079). No statistically significant differences were observed between the two groups for postoperative complications, and no recurrence reported at 11 months follow-up. There was no significant difference in the pain scores (visual analog scale) between the two groups at regular intervals post surgery. The outcomes after laparoscopic TEP inguinal hernia repair with a single-port device are comparable to the standard three-port technique.

  15. Contralateral metachronous inguinal hernias in adults: role for prophylaxis during the TEP repair.

    Science.gov (United States)

    Zendejas, B; Onkendi, E O; Brahmbhatt, R D; Greenlee, S M; Lohse, C M; Farley, D R

    2011-08-01

    Contralateral exploration during laparoscopic totally extraperitoneal (TEP) inguinal herniorrhaphy allows for the repair of incidentally found hernias. Nonetheless, some patients with a negative contralateral exploration subsequently develop a symptomatic hernia on that side. We pondered the incidence of contralateral metachronous hernia development and whether prophylactic "repair" in these circumstances would be beneficial. A retrospective analysis of patients who underwent laparoscopic TEP exploration at our institution was performed. Demographic, operative and follow-up information was obtained through medical record review, physical examination and telephone/mailed survey. From 1995 to 2009, a total of 1,479 inguinal herniorrhaphies on 976 patients were performed by a single staff surgeon. Bilateral exploration was completed in 923 (95%) of these patients, of whom bilateral repair was performed on 503 (55%). The study cohort comprises the 409 (42%) patients having a unilateral repair with a negative contralateral exploration and no previous contralateral hernia repair (n = 11). With a median follow-up of 5.9 years (range 0-14), 33 (8.1%) hernias developed on the previously "healthy" side, yielding incidence rates at 1, 5 and 10 years of 1.6, 5.9 and 11.8%, respectively. The median time to hernia development was 3.7 years (range 0.1-12.4). Of the 30 inguinal hernias that have been repaired, 25 (83%), 3 (10%) and 2 (7%) were of indirect, direct and pantaloon types, respectively. When considering prophylactic repair during TEP explorations, a yearly risk of 1.2% of developing a contralateral hernia after negative exploration needs to be balanced against the low but potential risk of groin pain following prophylactic repair.

  16. Review of 1000 fibrin glue mesh fixation during endoscopic totally extraperitoneal (TEP) inguinal hernia repair.

    Science.gov (United States)

    Berney, Christophe R; Descallar, Joseph

    2016-10-01

    Chronic pain is a common complication arising after conventional open herniorrhaphy and to a lesser extent postlaparoscopic inguinal hernia repairs as groin incision is avoided. Although published studies support elimination of mesh fixation during endoscopic procedures, the vast majority of surgeons will still recommend it by fear of encountering increased recurrence rates, if omitted. Regrettably, penetrating staple or tack fixation devices are the preferred methods to secure the mesh and cannot be applied at the level of the triangles of 'doom' and 'pain' where hernia tends to reoccur the most. This ongoing prospective cohort study aimed to confirm the safety and advantages of fibrin glue, as a substitute to staple mesh fixation during totally extraperitoneal (TEP) inguinal hernia repair. Over a 10-year period, 703 patients underwent 1000 elective TEP inguinal hernia repairs. Mesh fixation was achieved using exclusively fibrin sealant. Patients were reviewed at 2, 6 weeks and thereafter on an ad hoc basis if judged necessary until complete resolution of their symptoms. Quality of life (QoL) was assessed in a subgroup of 320 patients using the Carolina Comfort Scale (CCS). No conversion to open surgery was observed. There were three cases of major morbidities and no mortality. Three months after surgery, only seven patients (1 %) experienced chronic groin or testicular discomfort and none of them required prescription painkillers. When using the CCS, at 2 weeks 93.1 % of the patients were either satisfied or very satisfied with their outcome. This satisfaction index increased up to 99.2 % at 6 weeks post surgery. Finally, only eight hernia recurrences (1.1 %) were reported, of which five occurred during the first month of the study. Fibrin glue mesh fixation of inguinal hernia during TEP repair is extremely safe and reliable, with a very high satisfaction index for the patients and limited risk of developing chronic pain.

  17. Patient-reported outcomes (PROs) after total extraperitoneal hernia repair (TEP).

    Science.gov (United States)

    Mommers, E H H; Hünen, D R M; van Hout, J C H M; Guit, M; Wegdam, J A; Nienhuijs, S W; de Vries Reilingh, T S

    2017-02-01

    Patient-reported outcomes (PROs) such as quality of life (QoL), patient satisfaction, and work impairment, are arguably the most important outcomes of any medical treatment. In 2011, Staerkle and Villiger developed the Core Outcome Measurements Index (COMI) to standardise PROs and PRO measurement for inguinal hernia patients, in an attempt to increase inter-study comparability. The aim of this study is to prospectively evaluate the short- and long-term postoperative QoL, function, patient well-being, pain, and social/work disability, after total extraperitoneal (TEP) inguinal hernia repair and to provide the first clinical experience with the COMI-hernia questionnaire. Between January 2013 and December 2014, all patients ≥18 years that were scheduled for elective uni- or bilateral TEP in a regional hospital were approached to participate in this study. Measurements were taken preoperatively, and 6 weeks and 1 year postoperatively. One hundred and twenty patients (113 men, 7 women), mean age 59 years (SD ±12), completed the follow-up of 1 year. Ninety-seven percent of the population reported that the operation improved their complaints. QoL, function, well-being, and pain all improved after 6 weeks and 1 year after surgery. Patients experienced more social and work-related limitations 6 weeks after surgery compared to baseline measurements, though this improved to normal 1 year postoperatively. The incidence of chronic pain was 14% (VAS ≥ 2), which had a negative impact on the patients' sense of well-being. Patients recovered well after TEP repair with a good quality of life and fast restore of function. Patient well-being was lower than expected due to a 14% incidence of chronic pain. The COMI-hernia scale provided reasonable insight into the patients' experience, though it was difficult to interpret for both patient and physician.

  18. Prospective randomized trial comparing laparoscopic transabdominal preperitoneal (TAPP) and laparoscopic totally extra peritoneal (TEP) approach for bilateral inguinal hernias.

    Science.gov (United States)

    Sharma, Deborshi; Yadav, Kamal; Hazrah, Priya; Borgharia, Saurabh; Lal, Romesh; Thomas, Shaji

    2015-10-01

    Bilateral inguinal hernias form a part of the complex spectrum of weakness in the region of the myopectineal orifice. Laparoscopic surgery is one of the standard approaches for bilateral hernias. We describe the results of a randomized trial that was undertaken to compare and evaluate TAPP and TEP repair for bilateral inguinal hernias. Sixty patients were randomized into two groups. Group I (TAPP) and Group II (TEP) were compared in terms of procedure related variables, conversion, post-operative recovery and complications. Analysis was done using SPSS software version 17. Seventy-seven patients were assessed for fitness to include in the study. Seventeen patients had to be excluded due to either not meeting the inclusion criteria's or for not giving consent. The median age (52 yrs) was comparable in both groups. In Group II (TEP) mean operating time was 120.89 ± 29.28 min compared to 108.16 ± 16.10 min in Group I (TAPP). Post-operative pain scores were less in Group I(TAPP) at all levels of recording (8 h-48 h), though most patients required injectable analgesic for 32 h in both groups (p-value 0.029). Subcutaneous emphysema was more commonly noted in the Group II (TEP) (p-value 0.038). In Group I (TAPP) mean hospital stay was 52.0 ± 14.21 h while in Group II (TEP) it was 52.29 ± 9.36 h (p-value 0.427). Mean time for return to work was 11.8 ± 2.35 days in Group I (TAPP) and 12.41 ± 2.22 days in Group II (TEP) (p-value 0.339). The procedures though different in approach were quite similar in outcome. Mean operating time was increased in the TEP repairs along with immediate post-operative pain scores. The pattern of some complications like subcutaneous emphysema was significantly more in the TEP group while minor vascular injury though not significant was different in both groups. The indirect cost incurred from consumables did not vary other than need for more tacks in the TAPP group. Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd

  19. Male infertility after endoscopic Totally Extraperitoneal (Tep hernia repair (Main: rationale and design of a prospective observational cohort study

    Directory of Open Access Journals (Sweden)

    Schouten Nelleke

    2012-05-01

    Full Text Available Abstract Background To describe the rationale and design of an observational cohort study analyzing the effects of endoscopic Totally Extraperitoneal (TEP hernia repair on male fertility (MAIN study. Methods and design The MAIN study is an observational cohort study designed to assess fertility after endoscopic TEP hernia repair. The setting is a high-volume single center hospital, specialized in TEP hernia repair. Male patients of 18-60 years of age, with primary, reducible, bilateral inguinal hernias and no contraindications for endoscopic TEP repair are eligible for inclusion in this study. Patients with an ASA-classification ≥ III and patients with recurrent and/or scrotal hernias and/or a medical history of pelvic surgery and/or radiotherapy, known fertility problems, diabetes and/or other diseases associated with a risk of fertility problems, will be excluded. The primary outcome is the testicular perfusion before and 6 months after TEP hernia repair (assessed by means of a scrotal ultrasonography. Secondary endpoints are the testicular volume (Ultrasound, semen quality and quantity and the endocrinological status, based on serum levels of the sexual hormones follicle-stimulating hormone (FSH, luteinizing hormone (LSH, testosterone and inhibin B before and 6 months after TEP hernia repair. Discussion The use of polypropylene mesh is associated with a strong foreign body reaction which could play a role in chronic groin pain development. Since the mesh in (endoscopic inguinal hernia repair is placed in close contact to the vas deferens and spermatic vessels, the mesh-induced inflammatory reaction could lead to a dysfunction of these structures. Relevant large and prospective clinical studies on the problem are limited. This study will provide a complete assessment of fertility in male patients who undergo simultaneous bilateral endoscopic TEP hernia repair, by analyzing testicular perfusion and volume, semen quantity and quality

  20. Endoscopic surgeons' preferences for inguinal hernia repair: TEP, TAPP, or OPEN.

    Science.gov (United States)

    Morales-Conde, Salvador; Socas, María; Fingerhut, Abe

    2012-09-01

    The use of endoscopic inguinal hernia repair has slowly increased in the past years, but the indications have remained vague. Some surgeons perform a tailored approach depending on patient or hernia characteristics, whereas others perform the same approach and technique for all hernias. Based on these principles, a survey of 19 questions was conducted during the 18th Congress of the European Association of Endoscopic Surgeons, which took place in Geneva, Switzerland, in 2010, to determine surgeons' preference depending on the hernia and the patient. All surgeons who attended the session (N = 100) responded to all questions. Eighty two percent of surgeons preferred a tailored approach, whereas 18 % used the same technique in all cases. Endoscopic techniques are used more frequently than the open approach in bilateral (7 vs. 93 %) and recurrent hernias (19 vs. 81 %), whereas in primary unilateral hernias all three techniques were used with almost similar frequency (32 % open, 39 % TAPP vs. 29 % TEP). TAPP was used more frequently than TEP, and even those surgeons who are expert in TEP preferred to perform a TAPP in difficult hernias, such as in obese patients and large scrotal hernias. Based on the age of patients, the open approach is preferred in patients younger than 18 years and older than 70 years, whereas the endoscopic approach is preferred in young active males and females, with a trend to use TAPP (44 %) more frequently than TEP (40 %) in females. Surgeons tended to use the open (vs. endoscopic) approach in patients with hematologic disorders (58 % open vs. 42 % endoscopic), previous laparotomy (59 % open vs. 41 % endoscopic) or emergency surgery (66 vs. 33 % in incarcerated hernias and 74 vs. 26 % in strangulated hernia). This survey showed that most surgeons who perform an endoscopic approach for inguinal hernia as the first option are convinced that not all hernias are good indications for this approach. On the other hand, most surgeons think that it is

  1. OR TEP-II: a FORTRAN Thermal-Ellipsoid Plot Program for crystal structure illustrations

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, C.K.

    1976-03-01

    A computer program is described for drawing crystal structure illustrations using a mechanical plotter. Ball-and-stick type illustrations of a quality suitable for publication are produced with either spheres or thermal-motion probability ellipsoids on the atomic sites. The program can produce stereoscopic pairs of illustrations which aid in the visualization of complex packing arrangements of atoms and thermal motion patterns. Interatomic distances, bond angles, and principal axes of thermal motion are also calculated to aid the structural study. The most recent version of the program, OR TEP-II, has a hidden-line-elimination feature to omit those portions of atoms or bonds behind other atoms or bonds.

  2. Effects of blood glucose level on FDG uptake by liver: a FDG-PET/CT study

    Energy Technology Data Exchange (ETDEWEB)

    Kubota, Kazuo, E-mail: kkubota@cpost.plala.or.j [Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo 162-8655 (Japan); Watanabe, Hiroshige; Murata, Yuji [Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan); Yukihiro, Masashi; Ito, Kimiteru; Morooka, Miyako; Minamimoto, Ryogo [Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo 162-8655 (Japan); Hori, Ai [Department of Epidemiology and International Health, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655 (Japan); Shibuya, Hitoshi [Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8519 (Japan)

    2011-04-15

    In FDG-PET for abdominal malignancy, the liver may be assumed as an internal standard for grading abnormal FDG uptake both in early images and in delayed images. However, physiological variables of FDG uptake by the liver, especially the effects of blood glucose level, have not yet been elucidated. Methods: FDG-PET studies of 70 patients examined at 50 to 70 min after injection (60{+-}10 min: early images) and of 68 patients examined at 80 to 100 min after injection (90{+-}10 min: delayed images) were analyzed for liver FDG uptake. Patients having lesions in the liver, spleen and pancreas; patients having bulk tumor in other areas; and patients early after chemotherapy or radiotherapy were excluded; also, patients with blood glucose level over 125 mg/dl were excluded. Results: Mean standardized uptake value (SUV) of the liver, blood glucose level and sex showed no significant differences between early images and delayed images. However, liver SUV in the delayed image showed a larger variation than that in the early image and showed significant correlation to blood glucose level. The partial correlation coefficient between liver SUV and blood glucose level in the delayed image with adjustment for sex and age was 0.73 (P<.0001). Multivariate regression coefficient (95% confidence interval) of blood glucose was 0.017 (0.013-0.021). Conclusion: Blood glucose level is an important factor affecting the normal liver FDG uptake in nondiabetic patients. In the case of higher glucose level, liver FDG uptake is elevated especially in the delayed image. This may be due to the fact that the liver is the key organ responsible for glucose metabolism through gluconeogenesis and glycogen storage.

  3. Low recurrence rate after laparoscopic (TEP) and open (Lichtenstein) inguinal hernia repair: a randomized, multicenter trial with 5-year follow-up.

    Science.gov (United States)

    Eklund, Arne S; Montgomery, Agneta K; Rasmussen, Ib C; Sandbue, Rune P; Bergkvist, Leif A; Rudberg, Claes R

    2009-01-01

    To compare a laparoscopic (totally extraperitoneal patch (TEP)) and an open technique (Lichtenstein) for inguinal hernia repair regarding recurrence rate and possible risk factors for recurrence. Laparoscopic hernia repair has been introduced as an alternative to open repair. Short-term follow-up suggests benefits for those patients operated with a laparoscopic approach compared with open techniques; ie, less postoperative pain and a shorter convalescence period. Long-term results, however, are less well known. The study was conducted as a multicenter randomized trial with a 5-year follow-up. A total of 1512 men aged 30 to 70 years, with a primary unilateral inguinal hernia, were randomized to either TEP or Lichtenstein repair. Overall, 665 patients in the TEP group and 705 patients in the Lichtenstein group were evaluable. The cumulative recurrence rate was 3.5% in the TEP group and 1.2% in the Lichtenstein group (P = 0.008). Test for heterogeneity revealed significant differences between individual surgeons. The exclusion of 1 surgeon, who was responsible for 33% (7 of 21) of all recurrences in the TEP group, lowered the cumulative recurrence rate to 2.4% in this group, which was not statistically different from that of the Lichtenstein group. The recurrence rate for both TEP and Lichtenstein repair was low. A higher cumulative recurrence rate in the TEP group was seen at 5 years. Further analysis revealed that this could be attributable to incorrect surgical technique.

  4. Author Details

    African Journals Online (AJOL)

    Nabil, Chikhaoui. Vol 23, No 1 (2016) - Articles Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG. Abstract PDF. ISSN: 1937-8688. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  5. Author Details

    African Journals Online (AJOL)

    Abdelatif, Benider. Vol 23, No 1 (2016) - Articles Carcinome cutané de Merkel: apport de la TEP-TDM au18FDG. Abstract PDF. ISSN: 1937-8688. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  6. Patterns of FDG uptake in stomach on FDG PET: correlation with endoscopic findings

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Min Jeong; Cheon, Gi Jeong; Kim, Seong Eun; Choi, Chang Woon; Lim, Sang Moo [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

    2004-07-01

    The purpose of our study was to find out the significant findings of stomach on FDG PET. Thirty-nine patients who underwent both FDG PET and endoscopy from Jun. 2003, to Aug. 2004 were included in our study. In all of them, FDG PET and gastrofibroscopy were performed within one week. One man who had undergone subtotal gastrectomy was excluded. We reviewed 38 cases (18 for medical check up, 15 for work up of other malignancies, and 5 for the evaluation of stomach lesion). Their mean age was 56 years old (range:32{approx}79), men and women were 28 and 10, respectively. On interpretation of FDG PET scan, two nuclear physician evaluated five parameters on FDG-PET findings of stomach with a concensus : 1) visual grades 2) maximum SUV (SUVmax), 3) focality, 4) asymmetry, and 5) gross appearance. We correlated FDG PET findings of stomach with those of endoscopy. On endoscopy, six of 38 patients were proven as gastric cancer, and others had inflammatory lesion (ulcer in 3, chronic gastritis in 12, uncommon from gastritis in 5) or benign noninflammatory lesions (polyp and varix in 3, and normal limit). On the visual analysis, FDG uptake of stomach cancer had the tendency of higher uptake than the other lesions. SUVmax of gastric cancer was 7.95{+-}4.83 which was significantly higher than the other benign lesions (2.9{+-}0.69 in ulcer, 3.08{+-}1.2 in chronic gastritis 3.2{+-}1.49 in uncommon from gastritis). In the appearance of stomach on PET, gastric cancer was shown as focal lesion (5 of 6), and those of benign inflammatory lesions were asymmetric (14 of 20), and diffuse (9 of 20). Some cases of chronic inflammatory lesions, such as ulcer, and chronic gastritis, showed focal appearance and mimicked cancerous lesion (4 of 15). On FDG PET, the lesions of stomach cancer had higher FDG uptake and focal appearance comparing with the other benign inflammatory lesions. However, ulcer, and chronic gastritis showed focal appearance on PET, which could be mimicked as cancerous

  7. Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients.

    Science.gov (United States)

    Atkinson, Wendy; Catana, Ciprian; Abramson, Jeremy S; Arabasz, Grae; McDermott, Shanaugh; Catalano, Onofrio; Muse, Victorine; Blake, Michael A; Barnes, Jeffrey; Shelly, Martin; Hochberg, Ephraim; Rosen, Bruce R; Guimaraes, Alexander R

    2016-07-01

    The goal of this study is to evaluate the diagnostic performance of simultaneous FDG-PET/MR including diffusion compared to FDG-PET/CT in patients with lymphoma. Eighteen patients with a confirmed diagnosis of non-Hodgkin's (NHL) or Hodgkin's lymphoma (HL) underwent an IRB-approved, single-injection/dual-imaging protocol consisting of a clinical FDG-PET/CT and subsequent FDG-PET/MR scan. PET images from both modalities were reconstructed iteratively. Attenuation correction was performed using low-dose CT data for PET/CT and Dixon-MR sequences for PET/MR. Diffusion-weighted imaging was performed. SUVmax was measured and compared between modalities and the apparent diffusion coefficient (ADC) using ROI analysis by an experienced radiologist using OsiriX. Strength of correlation between variables was measured using the Pearson correlation coefficient (r p). Of the 18 patients included in this study, 5 had HL and 13 had NHL. The median age was 51 ± 14.8 years. Sixty-five FDG-avid lesions were identified. All FDG-avid lesions were visible with comparable contrast, and therefore initial and follow-up staging was identical between both examinations. SUVmax from FDG-PET/MR [(mean ± sem) (21.3 ± 2.07)] vs. FDG-PET/CT (mean 23.2 ± 2.8) demonstrated a strongly positive correlation [r s = 0.95 (0.94, 0.99); p PET/MR [r = 0.17(-0.07, 0.66); p = 0.09]. FDG-PET/MR offers an equivalent whole-body staging examination as compared with PET/CT with an improved radiation safety profile in lymphoma patients. Correlation of ADC to SUVmax was weak, understating their lack of equivalence, but not undermining their potential synergy and differing importance.

  8. Prospective, randomized, controlled trial comparing lightweight versus heavyweight mesh in chronic pain incidence after TEP repair of bilateral inguinal hernia.

    Science.gov (United States)

    Chui, L B; Ng, W T; Sze, Y S; Yuen, K S; Wong, Y T; Kong, C K

    2010-11-01

    This prospective, clinical, randomized, controlled study was performed to define the incidence of chronic pain after total extraperitoneal (TEP) repair with a light-weighted mesh compared with heavyweight mesh in patients with bilateral inguinal hernias. Consecutive patients with bilateral inguinal hernias were recruited for TEP inguinal hernia repair under general anesthesia. Heavyweight mesh was randomly assigned to one side of the groin and lightweight mesh to the other. Patients were followed up regularly for up to 1 year by an independent surgeon who was unaware of the mesh assignment. The postoperative pain score by means of a visual analogue scale (VAS) and other data were recorded. Fifty bilateral TEP hernia repairs were performed between September 2007 and February 2009. Six patients (12%) complained of chronic pain 3 months after the operation. A higher average pain score was observed for the side of hernia repaired by heavyweight mesh compared with lightweight mesh, but the difference was not statistically significant. More patients complained about foreign body sensation on the side repaired with heavyweight mesh (24%) compared with the side with lightweight mesh (8%; P TEP inguinal hernia repair because it provides less postoperative foreign body sensation; however, there was no significant difference in the incidence of chronic pain.

  9. A Study of NSF Teacher Enhancement Program (TEP) Participants and Principal Investigators: 1984-1989. Volume II: Technical Report.

    Science.gov (United States)

    Abt Associates, Inc., Cambridge, MA.

    This study documents the effects of participation in the Teacher Enhancement Program (TEP) of the National Science Foundation (NSF). The NSF awarded more than 600 grants to scientists, mathematicians, and educators to develop and operate inservice teacher training programs between 1984 and 1989. The present study focuses specifically upon the…

  10. Long-term follow-up of laparoscopic total extraperitoneal (TEP) repair in inguinal hernia without mesh fixation.

    Science.gov (United States)

    Golani, S; Middleton, P

    2017-02-01

    From the current evidence, non-fixation of the mesh (NMF) in laparoscopic total extraperitoneal (TEP) repair appears to be a safe alternative for inguinal hernia patients in the short term. This study aims to demonstrate that NMF is as effective in the long term by following up a large number of patients with a mean follow-up of 6 years. The primary outcomes are chronic pain and recurrence rate. A thorough review of medical records was conducted from a prospectively maintained database of 538 patients who underwent a laparoscopic TEP inguinal hernia repair by a single surgeon working in Sydney from the year 2005 to 2010. Patient demographics, perioperative outcomes, and postoperative complications were extracted from this database. All these patients were then interviewed using a modified questionnaire based on Franneby et al. [10]. 538 patients had TEP repair between 2005 and 2010. Out of this 11 were excluded as tacks were used for fixation of mesh. Out of the 649 repairs done on 527 patients during this period, 463 hernia repairs in 387 patients could be followed up with a mean follow-up of 6 years and 4 months. The mean age of patients was 63 years. Overall, there were seven (1.5%) recurrences, and the incidence of chronic pain was 1%, however 2.9% patients in total complained of pain. This is the only study in literature having a long-term follow-up of more than 5 years for the patients having inguinal hernia repair by TEP technique without mesh fixation. It demonstrates that fixation of mesh with tacks or glue is unnecessary for TEP repair of inguinal hernia.

  11. FDG uptake in the pathologically proven papillary thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Sung; Yun, Mi Jin; Cho, Arthur; Lee, Jong Doo [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2007-02-15

    Metastatic thyroid cancers with I-131 uptake have been known to show no increase of FDG uptake whereas those without I-131 uptake tend to demonstrate increased uptake on PET. In this study, we evaluated the degree of FDG uptake in primary thyroid cancers of papillary histology before surgery. Forty FDG PET studies were performed on the patients who had papillary cancer proven by fine needle aspiration. The degree of FDG uptake was visually categorized as positive or negative (positive if the tumor showed discernible FDG; negative if the tumor didn't) and the peak standard uptake value (peak SUV) of the papillary thyroid cancer (PTC) were compared with the size of PTC. The mean size of 26 PTC with positive FDG uptake was 1.9{+-} 1.4 cm (0.5 {approx} 5 cm). In 13 PTC with negative FDG uptake, the mean size of those was 0.5 {+-} 0.2 cm (0.2 {approx} 0.9 cm). All PTC larger than 1 cm (2.5 {+-}1.4 cm, 1 {approx} 5 cm) have positive FDG uptake (peak SUV = 6.4 {+-} 5.7, 1.7 {approx} 22.7). Among the micropapillary thyroid cancer (microPTC; PTC smaller than 1 cm), 8 microPTC show positive FDG uptake (peak SUV = 2.9 {+-} 1.3, 1.7 {approx} 5.5), while 13 microPTC show negative finding (peak SUV 1.3 {+-} 0.2, 1.1{approx} 1.7). The size of microPTC with positive FDG uptake is significantly larger than that of microPTC with negative FDG uptake (0.7 {+-} 0.1cm vs 0.4 {+-} 0.2 cm, {rho} = 0.01). All PTCs larger than 1cm show positive FDG uptake in our study. In other words, thyroid lesions larger than 1cm with negative FDG uptake are unlikely to be PTC. So far, only poorly differentiated thyroid cancers are known to show increased FDG uptake. Our results seem to be contradictory to what is known in the literature. Further study is needed to understand better the significance of increased FDG uptake in PTC in relation to expression of NIS and GLUT.

  12. Data acquisition and PV module power production in upgraded TEP/AzRISE solar test yard

    Science.gov (United States)

    Bennett, Whit E.; Fishgold, Asher D.; Lai, Teh; Potter, Barrett G.; Simmons-Potter, Kelly

    2017-08-01

    The Tucson Electric Power (TEP)/University of Arizona AzRISE (Arizona Research Institute for Solar Energy) solar test yard is continuing efforts to improve standardization and data acquisition reliability throughout the facility. Data reliability is ensured through temperature-insensitive data acquisition devices with battery backups in the upgraded test yard. Software improvements allow for real-time analysis of collected data, while uploading to a web server. Sample data illustrates high fidelity monitoring of the burn-in period of a polycrystalline silicon photovoltaic module test string with no data failures over 365 days of data collection. In addition to improved DAQ systems, precision temperature monitoring has been implemented so that PV module backside temperatures are routinely obtained. Weather station data acquired at the test yard provides local ambient temperature, humidity, wind speed, and irradiance measurements that have been utilized to enable characterization of PV module performance over an extended test period

  13. LAS TIC-TAC-TEP: un referente para la educación policial

    Directory of Open Access Journals (Sweden)

    Gloria Esperanza Ortiz Russi

    2015-11-01

    Full Text Available La lectura que las autoras esbozan, hace parte de un discurso tejido durante años en trabajo continuo de cerca a la educación policial, desde el centro de Mediaciones Pedagógicas y Tecnológicas –CEMPE-, se puede comentar que dicho discurso es aún inacabado, pero sí propone una postura clave para ser tenida en cuenta en los procesos educativos que demandan la globalidad en una socio-cultura cada vez más inmersa en las TIC-TAC-TEP,  esas siglas tienen unas nuevas acepciones muy especiales para la educación y que desde la PONAL son necesarias trabajarlas.

  14. FDG-PET template MNI152 1mm

    DEFF Research Database (Denmark)

    2013-01-01

    A FDG-PET template in MNI space aligned to the MNI152 atlas This PET-FDG template is provided as is free of charge for all purposes, provided that the following paper is cited......(to appear) when ever the template is used. The authors cannot, under any circumstances, be held responsible for any...

  15. FDG-PET/CT in oncology. German guideline

    Energy Technology Data Exchange (ETDEWEB)

    Krause, B.J. [Nuklearmedizinische Klinik und Poliklinik, Technische Univ. Muenchen (Germany); Beyer, T.; Bockisch, A. [Klinik fuer Nuklearmedizin, Universitaetsklinikum Essen (Germany); Delbeke, D. [Vanderbilt Univ. Medical Center, Nashville, TN (United States); Kotzerke, J. [Klinik und Poliklinik fuer Nuklearmedizin, Universitaetsklinikum Dresden (Germany); Minkov, V. [Bundesamt fuer Strahlenschutz, Salzgitter (Germany); Reiser, M. [Inst. fuer Klinische Radiologie, Ludwig-Maximillians-Univ. Muenchen (Germany); Willich, N. [Klinik und Poliklinik fuer Strahlentherapie - Radioonkologie, Universitaetsklinikum Muenster (Germany)

    2007-07-01

    FDG-PET/CT examinations combine metabolic and morphologic imaging within an integrated procedure. Over the past decade PET/CT imaging has gained wide clinical acceptance in the field of oncology. This FDG-PET/CT guideline focuses on indications, data acquisition and processing as well as documentation of FDG-PET/CT examinations in oncologic patients within a clinical and social context specific to Germany. Background information and definitions are followed by examples of clinical and research applications of FDG-PET/CT. Furthermore, protocols for CT scanning (low dose and contrast-enhanced CT) and PET emission imaging are discussed. Documentation and reporting of examinations are specified. Image interpretation criteria and sources of errors are discussed. Quality control for FDG and PET/CT-systems, qualification requirements of personnel as well as legal aspects are presented. (orig.)

  16. System immune response to vaccination on FDG-PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Mingos, Mark; Howard, Stephanie; Giaclone, Micholas; Kozono, David; Jacene, Heather [Brigham and Women' s Hospital, Boston (United States)

    2016-12-15

    A patient with newly diagnosed right lung cancer had transient 18F-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2-3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.

  17. Coastal Thematic Exploitation Platform (C-TEP): An innovative and collaborative platform to facilitate Big Data coastal research

    Science.gov (United States)

    Tuohy, Eimear; Clerc, Sebastien; Politi, Eirini; Mangin, Antoine; Datcu, Mihai; Vignudelli, Stefano; Illuzzi, Diomede; Craciunescu, Vasile; Aspetsberger, Michael

    2017-04-01

    The Coastal Thematic Exploitation Platform (C-TEP) is an on-going European Space Agency (ESA) funded project to develop a web service dedicated to the observation of the coastal environment and to support coastal management and monitoring. For over 20 years ESA satellites have provided a wealth of environmental data. The availability of an ever increasing volume of environmental data from satellite remote sensing provides a unique opportunity for exploratory science and the development of coastal applications. However, the diversity and complexity of EO data available, the need for efficient data access, information extraction, data management and high spec processing tools pose major challenges to achieving its full potential in terms of Big Data exploitation. C-TEP will provide a new means to handle the technical challenges of the observation of coastal areas and contribute to improved understanding and decision-making with respect to coastal resources and environments. C-TEP will unlock coastal knowledge and innovation as a collaborative, virtual work environment providing access to a comprehensive database of coastal Earth Observation (EO) data, in-situ data, model data and the tools and processors necessary to fully exploit these vast and heterogeneous datasets. The cloud processing capabilities provided, allow users to perform heavy processing tasks through a user-friendly Graphical User Interface (GUI). A connection to the PEPS (Plateforme pour l'Exploitation des Produits Sentinel) archive will provide data from Sentinel missions 1, 2 and 3. Automatic comparison tools will be provided to exploit the in-situ datasets in synergy with EO data. In addition, users may develop, test and share their own advanced algorithms for the extraction of coastal information. Algorithm validation will be facilitated by the capabilities to compute statistics over long time-series. Finally, C-TEP subscription services will allow users to perform automatic monitoring of some key

  18. Totally extraperitoneal (TEP) endoscopic inguinal hernia repair with TAP (transversus abdominis plane) block as a day-case: a prospective cohort study.

    Science.gov (United States)

    Meyer, A; Bonnet, L; Bourbon, M; Blanc, P

    2015-06-01

    Totally extraperitoneal (TEP) endoscopic inguinal hernia repair is indicated for recurrent and bilateral inguinal hernias and traditionally is performed under general anesthesia. However, interventions that minimize pain and reduce opioid consumption have certain advantages for patients by avoiding side effects such as nausea and vomiting. The transversus abdominis plane (TAP) block has been used to minimize pain in a diverse range of surgical procedures but its safety on patients undergoing TEP repair has yet to be investigated. To assess the results of outpatient TEP repair with TAP block without curare. Consecutive patients undergoing elective TEP procedure were prospectively enrolled. Patients in two institutes received a similar anesthetic, surgical, and analgesic treatment protocol. Fifty consecutive day-case patients were included in this series. The TEP repair was successful in 49 patients and there was one conversion to transabdominal pre-peritoneal (TAPP) endoscopic inguinal hernia repair. The mean duration of surgery was 20min for unilateral hernia and 40min for bilateral hernia. These preliminary results suggest that day-case endoscopic hernia repair (TEP) with TAP block without curare is effective, safe, reproducible and can be proposed in all patients. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  19. Identification and functional analysis of a TEP gene from a crustacean reveals its transcriptional regulation mediated by NF-κB and JNK pathways and its broad protective roles against multiple pathogens.

    Science.gov (United States)

    Li, Chaozheng; Li, Haoyang; Xiao, Bang; Chen, Yonggui; Wang, Sheng; Lǚ, Kai; Yin, Bin; Li, Sedong; He, Jianguo

    2017-05-01

    Thioester-containing proteins (TEPs) are present in a wide range of species from deuterostomes to protostomes and are thought to be involved in innate immunity. In the current study, a TEP gene homologous to insect TEPs (iTEP) from the crustacean Litopenaeus vannamei, named LvTEP1, is cloned and functionally characterized. The open reading frame (ORF) of LvTEP1 is 4383 bp in length, encoding a polypeptide of 1460 amino acids with a calculated molecular weight of 161.1 kDa LvTEP1, which is most similar to other TEPs from insects, contains some conserved sequence features, including a N-terminal signal peptide, a canonical thioester (TE) motif, and a C-terminal distinctive cysteine signature. LvTEP1 is expressed in most immune-related tissues, such as intestine, epithelium, and hemocytes, and the mRNA level of LvTEP1 is upregulated in hemocytes after bacterial and viral challenges, indicating its involvement in the shrimp innate immune response. An expression assay in Drosophila S2 cells shows LvTEP1 to be a full-length secretory protein, and processed forms are present in the supernatant. Of note, only the processed form of LvTEP1 protein can bind to both the gram-negative bacterium Vibrio parahaemolyticus and the gram-positive bacterium Staphylococcus aureus in vitro, and its abundance can be induced after bacterial treatment. Moreover, knockdown of LvTEP1 renders shrimps more susceptible to both V. parahaemolyticus and S. aureus, as well as white spot syndrome virus (WSSV) infection, suggesting its essential defensive role against these invading microbes. We also observe that the expression of LvTEP1 is regulated in a manner dependent on both NF-κB and AP-1 transcription factors in naive shrimps and in vitro, suggesting that LvTEP1 could be poised in the body cavity prior to infection and thus play an important role in basal immunity. Taken together, our findings provide some in vitro and in vivo evidence for the involvement of LvTEP1 in shrimp innate

  20. Marine aggregates and transparent exopolymeric particles (TEPs) as substrates for the stramenopilan fungi, the thraustochytrids: Roller table experimental approach.

    Digital Repository Service at National Institute of Oceanography (India)

    Damare, V.S.; Raghukumar, S.

    , stramenopilan fungi and are found in a wide variety of habitats, like coastal and oceanic waters, soils, mangroves, seagrasses (Raghukumar, 2002). Recently they have gained biotechnological importance due to the production of polyunsaturated fatty acids... arrangement at a speed of 23 rpm (Damare et al., 2011). Sunpet bottles with screw capped lids were used as sampling bottles and were surface sterilized with ethanol prior to use. Formation of TEPS/aggregates from coastal waters of Goa. Experiments were...

  1. Bilateral endoscopic total extraperitoneal (TEP) inguinal hernia repair does not induce obstructive azoospermia: data of a retrospective and prospective trial.

    Science.gov (United States)

    Skawran, S; Weyhe, D; Schmitz, B; Belyaev, O; Bauer, K H

    2011-07-01

    The endoscopic totally extraperitoneal (TEP) mesh repair is nowadays a well-established tension-free method for inguinal hernia repair. Mainly based on animal studies and case reports, a concern about the risk of postoperative infertility was expressed. This clinical study aimed to evaluate the risk of infertility due to obstructive azoospermia in men of fertile age who underwent a bilateral hernia repair. Over 3 years (2005-2008) 59 male patients, 18-60 years of age, underwent a bilateral TEP repair. Twenty-one of them were prospectively ("light mesh") and 38 retrospectively ("heavy mesh") evaluated for testicular volume and perfusion, serum levels of sexual hormones, ejaculate volume, and number of spermatic cells. Those parameters were determined preoperatively (prospective group) and not earlier than 3 months postoperatively (both groups). No significant difference between pre- and postoperative values was detected in the prospectively studied group. All postoperative parameters were within the normal range in the retrospective group. There was no evidence of impaired fertility in any patient due to the operation. The standardized TEP technique for simultaneous bilateral inguinal hernia repair in male patients was not associated with a higher risk for postoperative infertility after mesh implantation. The use of heavy-weight meshes had no negative effect on fertility.

  2. A Prospective Randomized Controlled Trial Comparing Quality of Life Following Endoscopic Totally Extraperitoneal (TEP) Versus Open Stoppa Inguinal Hernioplasty.

    Science.gov (United States)

    Kushwaha, Jitendra K; Enny, Loreno E; Anand, Akshay; Sonkar, Abhinav A; Kumar, Awanish; Pahwa, Harvinder S

    2017-08-01

    In inguinal hernia surgery, quality of life (QOL) has emerged as a striking issue. Evidence suggests better QOL of patients operated with laparoscopic procedure as compared with open anterior hernia repairs. However data are scarce with relation to open posterior repair in terms of QOL issues. A prospective randomized single-blind study from November 2014 to October 2015 including all patients who underwent elective primary endoscopic [totally extraperitoneal (TEP)] or open Stoppa inguinal hernia repair was undertaken. Mean operating time, intraoperative and postoperative complications, and QOL using short form-36 and Carolinas equation of QOL were analyzed. Physical functioning, mental health, bodily pain, and general health showed advantages of TEP over Stoppa repair in first month of postoperative period. Postoperative prediction of hernia discomfort after 1 year was found to be significantly more in Stoppa repair. Complications were slightly higher with open repair. To conclude TEP is associated with significant increased operative time, better QOL in early postoperative period, and less predicted discomfort after 1 year of surgery.

  3. F-18 FDG PET finding in autonomous thyroid nodules

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chan H.; Lee, Myoung Hoon; Yoon, Seek Nam; Hwang, Kyung Hoon [College of Medicine, Ajou Univ., Suwon (Korea, Republic of)

    2001-07-01

    F-18 FDG PET has become an important diagnostic imaging modality of various malignancies including thyroid cancer. Focal hypermetabolic lesion in the thyroid gland is usually considered malignant (Fig.1), although some benign lesions are also hypermetabolic. The aim of our poster presentation is to demonstrate F-18- FDG PET finding in autonomous thyroid nodules (ATN) and to avoid confusion in the interpretation of F-18-FDG PET performed for the evaluation of thyroid malignancy. Two patients with ATN (one with toxic and the other with nontoxic) underwent F-18-PET. ATN was proven by Tc-99m pertechnate thyroid scan (TS) and thyroid function tests (TFTs) were performed. First patient with ATN was asymptomatic and had a long history of thyroid nodule. Second patient was suffering from acute myelogenous leukemia (AML) and he was mildly thyrotoxic clinically and chemically. Gamma camera based F-18 FDG PET was performed utilizing Elscints Varicam (Haifa, Israel) one hour after IV administration of 111 MBq (3mCi) F-18 FDG. Patients were fasting more than 6 hours prior ot FDG injection. First patients was scanned the neck and second patient had scan of the whole trunk including neck for the evaluation of AML. Both nontoxic and toxic ATNs were hypermetabolic and it was impossible to differentiate benign from malignancy. Biopsy of nodule of the first patient and surgical removal of the nodule in the second patient was benign. Benign nontoxic and toxic ATNs are F-18 FDG avid. The reason for this is that ATN has increased glycolysis and iodide metabolism. Therefore, focal increased FDG uptake within the thyroid gland should be interpreted with TS and TFTs for an accurate diagnosis when F-18 FDG PET is used in the evaluation of thyroid malignancy.

  4. TEP under general anesthesia is superior to Lichtenstein under local anesthesia in terms of pain 6 weeks after surgery: results from a randomized clinical trial.

    Science.gov (United States)

    Dahlstrand, Ursula; Sandblom, Gabriel; Ljungdahl, Mikael; Wollert, Staffan; Gunnarsson, Ulf

    2013-10-01

    Persistent pain is common after inguinal hernia repair. The methods of surgery and anesthesia influence the risk. Local anesthesia and laparoscopic procedures reduce the risk for postoperative pain in different time perspectives. The aim of this study was to compare open Lichtenstein repair under local anesthesia (LLA) with laparoscopic total extraperitoneal repair (TEP) with respect to postoperative pain. Between 2006 and 2010, a total of 389 men with a unilateral primary groin hernia were randomized, in an open-label study, to either TEP (n = 194) or LLA (n = 195). One patient in the TEP group and four in the LLA group were excluded due to protocol violation. Details about the procedure and patient and hernia characteristics were registered. Patients completed the Inguinal Pain Questionnaire (IPQ) 6 weeks after surgery. [The study is registered in ClinicalTrials.gov (No. NCT01020058)]. A total of 378 (98.4 %) patients completed the IPQ. One hundred forty-eight patients (39.1 %) reported some degree of pain, 22 of whom had pain that affected concentration during daily activities. Men in the TEP group had less risk for pain affecting daily activities (6/191 vs. 16/187; odds ratio [OR] 0.35; 95 % CI 0.13-0.91; p = 0.025). Pain prevented participation in sporting activities less frequently after TEP (4.2 vs. 15.5 %; OR 0.24; 95 % CI 0.09-0.56; p TEP procedure suffered less pain 6 weeks after inguinal hernia repair than those who underwent LLA. Groin pain affected the LLA patients' ability to perform strenuous activities such as sports more than TEP patients.

  5. FDG PET/CT in children and adolescents with lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Kluge, Regine; Kurch, Lars [University Hospital Leipzig, Department of Nuclear Medicine, Leipzig (Germany); Montravers, Francoise [Hospital Tenon, Department of Nuclear Medicine, Paris (France); Mauz-Koerholz, Christine [University Hospital Halle, Department of Paediatrics, Halle (Saale) (Germany)

    2013-04-15

    The aim of this review is to give an overview of FDG PET/CT applications in children and adolescents with lymphoma. Today, FDG PET is used for tailoring treatment intensity in children with Hodgkin lymphoma within the framework of international treatment optimisation protocols. In contrast, the role of this method in children with Non-Hodgkin lymphoma is not well defined. This paper overviews clinical appearance and metabolic behaviour of the most frequent lymphoma subtypes in childhood. The main focus of the review is to summarise knowledge about the role of FDG PET/CT for initial staging and early response assessment. (orig.)

  6. FDG PET/CT in Type I Glycogen Storage Disease.

    Science.gov (United States)

    Manca, Chloé; Claudin, Marine; Belle, Arthur; Marie, Pierre Yves; Verger, Antoine

    2016-04-01

    Type I glycogen storage disease (GSD) is a rare autosomal recessive disorder caused by glucose-6-phosphatase deficiency. We report herein the particular pattern provided by FDG PET imaging in a 33-year-old patient with type Ib GSD. PET images yielded evidence of a pulmonary infectious focus as well as of: (1) a dramatically enlarged liver leading to a high global FDG uptake, (2) increased bone marrow activity, (3) splenomegalia leading to a high global spleen uptake, (4) a diffuse enhancement in muscle FDG uptake.

  7. A preoperative hernia symptom score predicts inguinal hernia anatomy and outcomes after TEP repair.

    Science.gov (United States)

    Knox, Robert D; Berney, Christophe R

    2015-02-01

    The Carolinas comfort scale (CCS) is an ideal tool for assessing patients’ quality-of-life post hernia repair, but its use has been barely investigated preoperatively. The aim was to quantify preoperative symptoms and assess their relevance in predicting postoperative clinical outcomes following totally extraperitoneal (TEP) inguinal hernia repair. The CCS was modified for preoperative use (modified or MCCS) by omitting mesh sensation questioning. Data collection was prospective over a 16 months period. (M)CCS questionnaires were completed preoperatively and at 2 then 6 weeks post repair. Intraoperative findings were also recorded. One hundred and four consecutive patients consented for TEP repair were included using a fibrin glue mesh fixation technique. All three questionnaires were completed by 88 patients (84.6 %). Preoperative MCCS scores did not differ with age, obesity, the presence of bilateral or recurrent inguinal herniae or hernia type. Higher MCCS grouping [OR 4.3 (95 % CI 1.5–12.6)] and the presence of bilateral herniae [OR 8.5 (1.2–61.8)] were predictors of persisting discomfort at 6 weeks, with lower scores on MCCS [OR 16.4 (3.9–67.6), obesity (OR 9.9 91.6–63.2)] and recurrent hernia repair [OR 11.4 (1.4–91.0)] predicting increased discomfort at 2 weeks versus preoperatively. MCCS scores were inversely correlated with the size of a direct defect (r −0.42, p = 0.011) but did not differ with the intraoperative finding of an incidental femoral and/or obturator hernia. Female sex was strongly associated with recognition of a synchronous incidental hernia (5 vs 57 %, p = 0.001). Pre- and post-operative scoring of hernia specific symptoms should be considered as part of routine surgical practice, to counsel patients on their expectations of pain and discomfort post repair and to select those who might be more appropriate for a watchful waiting approach. Females with inguinal hernia warrant complete assessment of their groin hernial orifices

  8. Case report

    African Journals Online (AJOL)

    ebutamanya

    22 oct. 2015 ... La détection de cette métastase était grâce au TEP scan au 18 FDG. Ce bilan a conduit à un traitement par chimiothérapie systémique après biopsie exérèse de la localisation fessière. Les métastases musculaires squelettiques du cancer bronchique sont rares mais bien qu'indiquant un mauvais pronostic, ...

  9. Localization of Epileptogenic Zones using Partical Volume Corrected FDG Uptake on FDG PET and Voxel Based Morphometry on MRI

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Won Jun; Lee, Ho Young; Lee, Jae Sung; Lee, Dong Soo; Lee, Sang Kun; Chung, June Key; Lee, Myung Chul [College of Medicine, Univ. of Seoul National, Seoul (Korea, Republic of)

    2003-07-01

    Partial volume corrected (PVC) FDG uptake yields information about regional metabolic level void of volume change, and voxel based morphometry (VBM) yields objective information regarding gray matter concentration. We investigated the roles of PVC PET and VBM to localize epileptogenic zones in medial temporal lobe epilepsy (mTLE) and non-lesional neocortical epilepsy. As a control group for PVC, 40 normal volunteers without history of neurologic or psychiatric diseases underwent FDG PET and MRI. Seventeen mTLE patients (M: F=7: 10, age=309 y) and nine neocortical epilepsy patients (M: F=6: 3, age=246, lateral temporal: 5, frontal: 3, occipital: 1) confirmed by surgery or epilepsy board meeting were enrolled. Standard VBM analysis was performed using individual MRI images compared with those of age-matched controls. For PVC, FDG PET was co-registered with its own MRI. PVC PET was obtained by dividing spillover-corrected PET by smoothed gray matter image pixel by pixel. SPAM was applied as a mask of volume of interest (VOI) to calculate gyral FDG uptake on PVC-FDG PET. Hippocampus, amygdala, superior, middle, inferior temporal gyrus and parahippocampal gyrus were the gyral SPAM VOIs in mTLE. Globally normalized PVC-FDG counts were compared with those of age-matched controls in mTLE and neocortical epilepsy patients. In mTlE, PVC-FDG PET correctly localized epileptogenic zones with the accuracy of 76% (13/17) in hippocampus and 82% (14/17) in any of six regions. VBM correctly localized 59% (10/17) in mTLE. In neocortical epilepsy, PVC-FDG PET localized epileptogenic zones in 44%, and VBM in 33%, Using VBM and PVC-FDG PET altogether, epileptogenic zones were localized in 66% (6/9). In mTLE, gyral PVC FDG uptake of temporal lobes was useful in localizing epileptogenic zones by demonstrating partial volume-void FDG concentration. In non-lesional cryptogenic neocortical epilepsy, combination of PVC-FDG PET and VBM is recommended to localize epileptogenic zones.

  10. FDG-avid portal vein tumor thrombosis from hepatocellular carcinoma in contrast-enhanced FDG PET/CT

    Directory of Open Access Journals (Sweden)

    Canh Nguyen

    2015-01-01

    Full Text Available Objective(s: In this study, we aimed to describe the characteristics of portal vein tumor thrombosis (PVTT, complicating hepatocellular carcinoma (HCC in contrast-enhanced FDG PET/CT scan. Methods: In this retrospective study, 9 HCC patients with FDG-avid PVTT were diagnosed by contrast-enhanced fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT, which is a combination of dynamic liver CT scan, multiphase imaging, and whole-body PET scan. PET and CT DICOM images of patients were imported into the PET/CT imaging system for the re-analysis of contrast enhancement and FDG uptake in thrombus, the diameter of the involved portal vein, and characteristics of liver tumors and metastasis. Results: Two patients with previously untreated HCC and 7 cases with previously treated HCC had FDG-avid PVTT in contrast-enhanced FDG PET/CT scan. During the arterial phase of CT scan, portal vein thrombus showed contrast enhancement in 8 out of 9 patients (88.9%. PET scan showed an increased linear FDG uptake along the thrombosed portal vein in all patients. The mean greatest diameter of thrombosed portal veins was 1.8 ± 0.2 cm, which was significantly greater than that observed in normal portal veins (P<0.001. FDG uptake level in portal vein thrombus was significantly higher than that of blood pool in the reference normal portal vein (P=0.001. PVTT was caused by the direct extension of liver tumors. All patients had visible FDG-avid liver tumors in contrast-enhanced images. Five out of 9 patients (55.6% had no extrahepatic metastasis, 3 cases (33.3% had metastasis of regional lymph nodes, and 1 case (11.1% presented with distant metastasis. The median estimated survival time of patients was 5 months. Conclusion: The intraluminal filling defect consistent with thrombous within the portal vein, expansion of the involved portal vein, contrast enhancement, and linear increased FDG uptake of the thrombus extended from liver tumor are

  11. A prospective, randomized comparison of long-term outcomes: chronic groin pain and quality of life following totally extraperitoneal (TEP) and transabdominal preperitoneal (TAPP) laparoscopic inguinal hernia repair.

    Science.gov (United States)

    Bansal, Virinder Kumar; Misra, Mahesh C; Babu, Divya; Victor, Jonathan; Kumar, Subodh; Sagar, Rajesh; Rajeshwari, S; Krishna, Asuri; Rewari, Vimi

    2013-07-01

    Data are insufficient to compare transabdominal preperitoneal repair (TAPP) and total extraperitoneal (TEP) techniques of laparoscopic inguinal hernia repair. There is very scant data comparing the two techniques in terms of long-term outcomes, which include chronic groin pain, quality of life, and time to return to normal activity. This prospective, randomized, controlled trial compared TEP versus TAPP techniques of laparoscopic inguinal hernia repair in terms of these long-term outcomes. This study was conducted from May 1, 2007 to March 30, 2012. Patients with uncomplicated groin hernia were randomized to transabdominal preperitoneal (TAPP) or totally extraperitoneal (TEP) techniques. A total of 160 patients were randomized to group I (TEP) and 154 patients to group II (TAPP). Pain was assessed with Visual Analogue Scale (VAS) preoperatively and postoperatively at 24 h, 1 week, 6 weeks, 3, 6, and 12 months, and yearly thereafter. Quality of life was assessed with Short Form-36 version 2 (SF 36v2) preoperatively and postoperatively at 3 months follow-up. Demographic, clinical profiles, intraoperative, and early postoperative parameters were well matched. There was significantly higher acute pain following TAPP repair; however, the chronic groin pain was comparable in both TEP and TAPP. Preoperative pain and immediate postoperative pain had significant correlation with chronic groin pain. Significant improvement from preoperative to postoperative quality of life was seen in both TEP and TAPP repairs, but there was no difference between TEP and TAPP in postoperative period. Time to return to normal activity also was similar between the two groups. The TEP and TAPP techniques of laparoscopic repair of inguinal hernia have comparable long-term outcomes in terms of incidence of chronic groin pain, quality of life, and resumption of normal activities. Chronic groin pain had a significant correlation with preoperative pain and early postoperative pain. However, TAPP was

  12. Post-Surgical Atypical FDG-PET Uptake

    Science.gov (United States)

    Dubroff, Jacob G.; Alavi, Abass; Friedberg, Joseph S.; Cengel, Keith A.

    2011-01-01

    False positive recognition is crucial for proper interpretation of FDG-PET studies. The authors present a case of a woman who underwent surgery over a month prior to PET/CT imaging which revealed significant tracer uptake within muscles and soft tissue in several sites contralateral to the location of surgery. The FDG-PET images of this case illustrate the importance of communication between physicians ordering and physicians reading FDG-PET/CT scans as well as atypical FDG-PET findings that could be interpreted as concerning but are, in fact, innocuous. This study also demonstrates the unusual glucose metabolic patterns which may arise following treatment be it surgical, chemotherapeutic or radiation. PMID:19851183

  13. FDG-PET in monitoring therapy of breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Biersack, H.J.; Bender, H.; Palmedo, H. [Department of Nuclear Medicine, University Hospital Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn (Germany)

    2004-06-01

    Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) has been used successfully for the staging and re-staging of breast cancer. Another significant indication is the evaluation of therapy response. Only limited data are available on the use of FDG-PET in breast cancer after radiation therapy. The same holds true for chemotherapy. Only the therapy response in locally advanced breast cancer after chemotherapy has been investigated thoroughly. Histopathological response could be predicted with an accuracy of 88-91% after the first and second courses of therapy. A quantitative evaluation is, of course, a prerequisite when FDG-PET is used for therapy monitoring. Only a small number of studies have focussed on hormone therapy. In this context, a flare phenomenon with increasing standardised uptake values after initiation of tamoxifen therapy has been observed. More prospective multicentre trials will be needed to make FDG-PET a powerful tool in monitoring chemotherapy in breast cancer. (orig.)

  14. Thorax: normal and benign pathologic patterns in FDG-PET/CT imaging.

    Science.gov (United States)

    Wachsmann, Jason W; Gerbaudo, Victor H

    2014-04-01

    This article describes the normal patterns of thoracic (18)F-fluorodeoxyglucose (FDG) biodistribution, and expands on the role of FDG-PET/computed tomography (CT) for the evaluation of patients suffering from a spectrum of benign pathologic conditions that affect the chest. The discussion addresses the applications of FDG-PET/CT imaging in a wide variety of chest-related disorders. Familiarity with the normal thoracic biodistribution of FDG, coupled with knowledge of the potential nonmalignant causes of increased FDG uptake in the chest, is essential to minimize the incidence of incorrect interpretation of FDG-PET images in daily clinical practice. Copyright © 2014 Elsevier Inc. All rights reserved.

  15. AU BURKINA FASO

    African Journals Online (AJOL)

    Les moyennes sur la même ligne et possédant le même indice ne diffèrent pas significativement au seuil de 5 %. ME : mélange fourrager. 10-20-30 % : pourcentage de concentré. GMQ : Gain Moyen Quotidien. L'analyse des résultats des rations. 1 et 2 montre que l'accès au pâturage permet des performances supérieures.

  16. Materials development for solar thermoelectric generators, SOLAR-TEP - 2007 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Bocher, L.; Weidenkaff, A.

    2007-07-01

    This annual report for the Swiss Federal Office of Energy (SFOE) takes a look at the work done at the Swiss Federal Laboratories for Materials Science and Technology EMPA in 2007 on Thermoelectric applications that are emerging as a potential technology that allows the conversion of heat into electric power. This energy conversion procedure uses the Seebeck effect to generate electricity without using moving parts or any chemical conversion. The Solar-TEP project is based on the idea of the potential use of concentrated solar heat as a source of energy for Solar Thermoelectric Generators (Solar-TEG). The development of novel functional materials with enhanced figures of merit, high temperature stability, and without harmful effects is commented on. The authors state that oxide ceramics can be used at high temperatures due to their chemical stability and their resistance to thermal oxidation in air. The advantages offered by thermoelectric modules based on oxide materials for the generation of power with increased temperature operating ranges are discussed. Additionally, thermoelectric oxide devices which can be realised on the basis of low-cost materials with low toxicity are discussed.

  17. Usefulness of {sup 18}F-FDG-PET/CT in Evaluating a Brainstem Glioma in an Adult Patient with Neurofibromatosis Type 1

    Energy Technology Data Exchange (ETDEWEB)

    Treglia, Giorgio [Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Muoio, Barbara; Del Ciello, Annemilia [Univ. of the Sacred, Rome (Italy); Bertagna, Francesco [Univ. of Brescia, Brescia (Italy)

    2013-09-15

    We describe a case of a brainstem glioma (BSG) occurred in an adult patient with neurofibromatosis type 1 (NF1) and evaluated by Flourine-18-Fluorodeoxyglucose-positron emission tomography/computed tomography ({sup 18}F-FDG-PET/CT). A 32-year-old male patient with NF1 underwent brain magnetic resonance imaging (MRI) for the onset of diplopia, facial paresis and cerebellar signs and symptoms. MRI showed a brainstem lesion compatible with BSG. Biopsy was not performed. {sup 18}F-FDG-PET/CT demonstrated intense {sup 18}F-FDG uptake in the brainstem lesion, suggesting an aggressive neoplasm. The patient was referred to radiotherapy but he developed rapid disease progression. In this case, {sup 18}F-FDG-PET/CT provided useful information about this rare NF1-associated tumor. Subsequently, the patient was referred to radiotherapy, but he developed rapid disease progression and died 3 months later. NF-1 is an autosomal dominant disorder characterized by multiple cafe-au-lait spots, axillary and inguinal freckling, multiple cutaneous neurofibromas, and iris Lisch nodules. NF-1 is also characterized by low-grade tumors of the central and peripheral nervous system. There is also an increased risk of developing malignant tumors such as malignant peripheral nerve sheath tumors or central nervous system high-grade gliomas. NF1-associated BSGs are less common than NF1-associated optic gliomas (OGs) and seem to represent a particular entity which tend, as a whole, to have a more favorable prognosis and a more indolent course than BSGs in patients without NF1; nevertheless, some NF1-associted BSG may rapidly progress. {sup 18}F-FDG-PET/CT has demonstrated to provide useful information to the surveillance of OGs in children with NF1, particularly to identify progressive, symptomatic tumors. To the best of our knowledge, there are no data about the usefulness of {sup 18}F-FDG-PET/CT in adult patients with NF1-associated BSG. In our case, {sup 18}F-FDG-PET/CT has been useful in

  18. Functional neuroimaging in epilepsy: FDG-PET and SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Kun; Lee, Dong Soo [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2003-02-01

    Finding epileptogenic zone is the most important step for the successful epilepsy surgery. F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and single photon emission computed tomography (SPECT) can be used in the localization of epileptogenic foci. In medial temporal lobe epilepsy, the diagnostic sensitivity of FDG-PET and ictal SPECT is excellent. However, detection of hippocampal sclerosis by MRI is so certain that use of FDG-PET and ictal SPECT in medial temporal lobe epilepsy is limited for some occasions. In neocortical epilepsy, the sensitivities of FDG-PET or ictal SPECT are fair. However, FDG-PET and ictal SPECT can have a crucial role in the localization of epileptogenic foci for non-lesional neocortical epilepsy. Interpretation of FDG-PET has been recently advanced by voxel-based analysis and automatic volume of interest analysis based on a population template. Both analytical methods can aid the objective diagnosis of epileptogenic foci. lctal SPECT was analyzed using subtraction methods and voxel-based analysis. Rapidity of injection of tracers, ictal EEG findings during injection of tracer, and repeated ictal SPECT were important technical issues of ictal SPECT. SPECT can also be used in the evaluation of validity of Wada test.

  19. Efficacy and safety of NBCA (n-butyl-2-cyanoacrylate) medical adhesive for patch fixation in totally extraperitoneal prosthesis (TEP): a prospective, randomized, controlled trial.

    Science.gov (United States)

    Shen, Y-M; Liu, Y-T; Chen, J; Sun, L

    2017-02-01

    To evaluate the effectiveness of n-butyl-2-cyanoacrylate (NBCA) medical adhesive for mesh fixation in totally extraperitoneal prosthesis (TEP) for inguinal hernia repair. A total of 160 patients with primary unilateral inguinal hernia were assigned randomly to receive TEP using NBCA medical adhesive for patch fixation (experimental group) and without patch fixation (control group). We evaluated operation time, visual analogue scale (VAS) pain score 24 h after surgery, postoperative duration of stay, hospital costs, postoperative complications, and hernia recurrence. A total of 160 cases were operated successfully. There was no significant difference in operation time, VAS pain score 24h after surgery, postoperative duration of stay, hospital costs and postoperative complications between the groups (p > 0.05). Hernia recurrence occurred in 4 cases of the control group. None of the experimental group had a significant difference (p TEP is effective and safe.

  20. The deep cerebral stimulation of the under thalamic nucleus modifies the cerebral metabolism in {sup 18}FDG-Tep of obsessive compulsive patients; La stimulation cerebrale profonde du noyau sous thalamique modifie le metabolisme cerebral en 18FDG-TEP des patients obsessionnels compulsifs

    Energy Technology Data Exchange (ETDEWEB)

    Le Jeune, F.; Garin, E. [Service de medecine nucleaire, centre Eugene-Marquis, Rennes, (France); Verin, M.; Peron, J. [service de neurologie, CHU Pontchaillou, Rennes, (France); Mallet, L.; Yelnik, J. [Inserm, Avenir Team, Behavior, Emotion and Basal Ganglia, IFR 70, Pitie-Salpetriere, Paris, (France); Kreps, M.O. [Inserm U796, service de psychiatrie, hopital Sainte-Anne, Paris, (France); Drapier, D.; Millet, B. [service de psychiatrie adulte, centre hospitalier Guillaume-Regnier, Rennes, (France)

    2009-05-15

    The aim of this work was to find again this orbito-frontal hyper metabolism among the resistant obsessive compulsive disorder patients that are going to benefit of a deep cerebral stimulation of the under thalamus nucleus and to demonstrate that this new therapy approach leads a reduction of the metabolism in this area in correlation with the clinical improvement. It is about the first study realized in isotopic functional imaging on ten resistant compulsive disorder patients treated by bilateral deep cerebral stimulation of the under thalamus nucleus. It shows that the treatment efficiency is in relation with a reduction of the glucide metabolism in the right orbito-frontal cortex. It suggests equally that the under thalamus nucleus would be functionally linked to the orbito-frontal cortex. (N.C.)

  1. Higher Recurrence Rate After Endoscopic Totally Extraperitoneal (TEP) Inguinal Hernia Repair With Ultrapro Lightweight Mesh: 5-Year Results of a Randomized Controlled Trial (TULP-trial).

    Science.gov (United States)

    Roos, Marleen; Bakker, Wouter J; Schouten, Nelleke; Voorbrood, Charlotte; Clevers, Geert Jan; Verleisdonk, Egbert Jan; Davids, Paul; Burgmans, Josephina

    2018-01-04

    The aim of this study was to determine inguinal hernia recurrence rates 5 years after endoscopic totally extraperitoneal (TEP) inguinal hernia repair when either lightweight or heavyweight mesh was used. Recurrence is an important complication of inguinal hernia surgery. Higher recurrence rates of Ultrapro lightweight meshes after TEP repair have been demonstrated, yet data regarding long-term follow-up are limited. From 2010 to 2012, 950 male adult patients with primary unilateral hernias were randomized to TEP hernia repair with heavyweight (Prolene) or lightweight (Ultrapro) mesh. Five years postoperatively, the validated PINQ-PHONE telephone questionnaire was carried out. Participants with a positive questionnaire reply were scheduled for a clinical visit. A recurrence was defined as a clinically detectable bulge in the operated groin on physical examination. Data on development of recurrence could be obtained from 790 patients (83.2% 5-year follow-up rate). Four patients presented with a recurrence at the outpatient clinic between 2 and 5 years postoperatively. Thirty-five patients (4.6%) with a positive PINQ-PHONE reply (60.0% lightweight vs 40.0% heavyweight) were physically examined at the outpatient clinic. In 2 patients (lightweight) a recurrence was detected. The total 5-year recurrence rate after TEP hernia repair was 2.4% (3.8% lightweight, 1.1% heavyweight, P = 0.01). A significantly higher recurrence rate for lightweight mesh in primary direct hernias was found (P = 0.003). The overall recurrence rate 5 years after TEP repair was low. Ultrapro lightweight meshes showed higher recurrence rates than heavyweight meshes and are not recommended for endoscopic TEP inguinal hernia repair.

  2. Brown adipose tissue {sup 18}F-FDG uptake in pediatric PET/CT imaging

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Terence S. [The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto (Canada); Shammas, Amer; Charron, Martin [The Hospital for Sick Children, Department of Diagnostic Imaging, Division of Nuclear Medicine, Toronto (Canada); Zukotynski, Katherine A. [Harvard Medical School, Department of Imaging, Division of Nuclear Medicine, Dana-Farber Cancer Institute, Boston, MA (United States); Drubach, Laura A. [Children' s Hospital Boston, Harvard Medical School, Department of Radiology, Division of Nuclear Medicine/PET, Boston, MA (United States); Lim, Ruth [Massachusetts General Hospital, Harvard Medical School, Department of Radiology, Boston, MA (United States)

    2011-06-15

    Positron emission tomography (PET) using [F-18]2-fluoro-2-deoxyglucose (FDG) fused with CT ({sup 18}F-FDG PET/CT) has been widely adopted in oncological imaging. However, it is known that benign lesions and other metabolically active tissues, such as brown adipose tissue (BAT), can accumulate {sup 18}F-FDG, potentially resulting in false-positive interpretation. Previous studies have reported that {sup 18}F-FDG uptake in BAT is more common in children than in adults. We illustrate BAT FDG uptake in various anatomical locations in children and adolescents. We also review what is known about the effects of patient-related physical attributes and environmental temperatures on BAT FDG uptake, and discuss methods used to reduce BAT FDG uptake on {sup 18}F-FDG PET. (orig.)

  3. Patterns of FDG uptake in stomach on F-18 FDG positron emission tomography: correlation with endoscopic findings

    Energy Technology Data Exchange (ETDEWEB)

    Chae, Min Jeong; Cheon, Gi Jeong; Lee, Sang Woo; Byun, Byung Hyun; Kim, Sung Eun; Kim, Yu Chul; Choi, Chang Woon; Lim, Sang Moo [Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

    2005-10-15

    We often find variable degrees of FDG uptake and patterns in stomach, which can make difficult to distinguish physiologic uptake from pathologic uptake on FDG PET. The purpose of this study was to find out the significant findings of stomach on FDG PET. Thirty-eight patients who underwent both FDG PET and endoscopy within one week from Jun. 2003, to Aug. 2004 were included in this study. We reviewed 38 patients (18 for medical check up, 15 for work up of other malignancies, and 5 for the evaluation of stomach lesion). Their mean age was 56 years old (range:32 {approx} 79), men and women were 28 and 10, respectively. Two nuclear physicians evaluated five parameters on FDG PET findings of stomach with a consensus: 1) visual grades 2) maximum SUV (max.SUV) 3) focal 4) diffuse and 5) asymmetric patterns. We correlated the lesions of FDG PET findings of stomach with those of endoscopy. We considered more than equivocal findings on FDG PET as positive. The six of 38 patients were proven as malignant lesions by endoscopic biopsy and others were inflammatory lesions (ulcer in 3, chronic atrophic gastritis in 12, uncommon forms of gastritis in 5), non-inflammatory lesions (n=3), and normal stomach (n=9). By the visual analysis, malignant lesions had higher FDG uptake than the others. The max.SUV of malignant lesions was 7.95 {+-} 4.83 which was significantly higher than the other benign lesions (2.9 {+-} 0.69 in ulcer, 3.08 {+-} 1.2 in chronic atrophic gastritis, 3.2 {+-} 1.49 in uncommon forms of gastritis ( {rho} =0.044). In the appearance of stomach on FDG PET, malignant lesions were shown focal (5 of 6) and benign inflammatory lesions were shown diffuse (9 of 20) and asymmetric (14 of 20). Benign lesions and normal stomach were shown variable degrees of uptake and patterns. Some cases of benign inflammatory lesions such as ulcer and gastritis were shown focal and mimicked cancerous lesions (4 of 15). Gastric malignant lesions had higher FDG uptake and focal pattern

  4. Diagnostic performance of FDG-PET/MRI and WB-DW-MRI in the evaluation of lymphoma: a prospective comparison to standard FDG-PET/CT.

    Science.gov (United States)

    Herrmann, Ken; Queiroz, Marcelo; Huellner, Martin W; de Galiza Barbosa, Felipe; Buck, Andreas; Schaefer, Niklaus; Stolzman, Paul; Veit-Haibach, Patrick

    2015-12-23

    Use of FDG-PET/CT for staging and restaging of lymphoma patients is widely incorporated into current practice guidelines. Our aim was to prospectively evaluate the diagnostic performance of FDG-PET/MRI and WB-DW-MRI compared with FDG-FDG-PET/CT using a tri-modality PET/CT-MRI system. From 04/12 to 01/14, a total of 82 FDG-PET/CT examinations including an additional scientific MRI on a tri-modality setup were performed in 61 patients. FDG-PET/CT, FDG-PET/MRI, and WB-DW-MRI were independently analyzed. A lesion with a mean ADC below a threshold of 1.2 × 10(-3) mm(2)/s was defined as positive for restricted diffusion. FDG-PET/CT and FDG-PET/MRI were evaluated for the detection of lesions corresponding to lymphoma manifestations according to the German Hodgkin Study Group. Imaging findings were validated by biopsy (n = 21), by follow-up imaging comprising CT, FDG-PET/CT, and/or FDG-PET/MRI (n = 32), or clinically (n = 25) (mean follow-up: 9.1 months). FDG-PET/MRI and FDG-PET/CT accurately detected 188 lesions in 27 patients. Another 54 examinations in 35 patients were negative. WB-DW-MRI detected 524 lesions, of which 125 (66.5% of the aforementioned 188 lesions) were true positive. Among the 188 lesions positive for lymphoma, FDG-PET/MRI detected all 170 instances of nodal disease and also all 18 extranodal lymphoma manifestations; by comparison, WB-DW-MRI characterized 115 (67.6%) and 10 (55.6%) lesions as positive for nodal and extranodal disease, respectively. FDG-PET/MRI was superior to WB-DW-MRI in detecting lymphoma manifestations in patients included for staging (113 vs. 73), for restaging (75 vs. 52), for evaluation of high- (127 vs. 81) and low-grade lymphomas (61 vs. 46), and for definition of Ann Arbor stage (WB-DW-MRI resulted in upstaging in 60 cases, including 45 patients free of disease, and downstaging in 4). Our results indicate that FDG-PET/CT and FDG-PET/MRI probably have a similar performance in the clinical work-up of lymphomas. The performance

  5. Hepatosplenic Cat-Scratch Disease in Children and the Positive Contribution of F-18-FDG Imaging

    NARCIS (Netherlands)

    Kraft, Karianne E.; Doedens, Rienus A.; Slart, Riemer H. J. A.

    Two patients were referred to our hospital because of suspected malignancy. In patient 1, a 4-year-old boy, a F-18-FDG PET scan showed an enlarged liver with multiple FDG-positive nodular lesions. In patient 2, a 16-year-old boy, a FDG PET-(low-dose) CT showed an enlarged liver and spleen with

  6. Comparison of F-18-FLT PET and F-18-FDG PET in esophageal cancer

    NARCIS (Netherlands)

    van Westreenen, HL; Cobben, DCP; Jager, PL; van Dullemen, HM; Wesseling, J; Elsinga, PH; Plukker, JT

    F-18-FDG PET has gained acceptance for staging of esophageal cancer. However, FDG is not tumor specific and false-positive results may occur by accumulation of FDG in benign tissue. The tracer F-18-fluoro-3'-deoxy-3'-L-fluorothymidine (F-18-FLT) might not have these drawbacks. The aim of this study

  7. Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy

    NARCIS (Netherlands)

    Kwee, Thomas C.; de Klerk, John M. H.; Nix, Maarten; Heggelman, Ben G. F.; Dubois, Stefan V.; Adams, Hugo J. A.

    Positron emission tomography with the radiotracer F-18-fluoro-2-deoxy-D-glucose (FDG) plays an important role in the evaluation of bone pathology. However, FDG is not a cancer-specific agent, and knowledge of the differential diagnosis of benign FDG-avid bone alterations that may resemble malignancy

  8. Dual time-point FDG PET/CT and FDG uptake and related enzymes in lymphadenopathies

    DEFF Research Database (Denmark)

    Christlieb, Sofie Bæk; Nørgaard Strandholdt, Casper; Olsen, Birgitte Brinkmann

    2016-01-01

    , cSUVmean (with partial volume correction), total lesion glycolysis (TLG) and cTLG (with partial volume correction). Expression of glucose transporter-1 (GLUT-1), hexokinase-II (HK-II), glucose-6-phosphatase (G6Pase) and hypoxia-inducible factor-1alpha (HIF-1alpha) were assessed...... with immunohistochemistry and enzyme activity was determined for HK and G6Pase. RESULTS: FDG uptake was assessed in 203 lesions (146 malignant and 57 benign). Besides volume, there were significant increases over time for all parameters, with generally higher levels in the malignant lesions. The retention index (RI...

  9. Comparison of 18F-FDG-PET/CT and 18F-FDG-PET/MR imaging in oncology: a systematic review.

    Science.gov (United States)

    Singnurkar, Amit; Poon, Raymond; Metser, Ur

    2017-06-01

    The aim of this study was to systematically review the literature to evaluate the clinical performance of integrated 18F-FDG PET/MR as compared with 18F-FDG PET/CT in oncologic imaging. The literature was searched using MEDLINE and EMBASE via OVID. Studies comparing the diagnostic accuracy of integrated 18F-FDG PET/MR and 18F-FDG PET/CT in the diagnosis, staging/restaging, assessment of treatment response, or evaluation of metastasis in patients with suspected or diagnosed cancers were deemed eligible for inclusion. Risk of bias and applicability concerns were assessed using the QUADAS-2 tool. Twenty studies met the inclusion criteria. The overall quality of the studies was rated favorably with bias or applicability concerns in a few studies. Our review suggests that 18F-FDG PET/MR performs comparably to 18F-FDG PET/CT in the detection of local lymph node and distant metastases and superiorly in determining the local extent of tumor. SUV obtained from 18F-FDG PET/MR correlated highly with those obtained from 18F-FDG PET/CT. Based on early evidence, 18F-FDG PET/MR is comparable to 18F-FDG PET/CT in the clinical scenarios examined in this review. The potential for interchangeability of 18F-FDG PET/MR with 18F-FDG PET/CT will vary by indication and the body site that is being imaged, with PET scanners integrated with MRI predicted to provide greater detail in the evaluation of local tumor extent, where 18F-FDG PET/CT can be limited.

  10. Effect of glucose level on brain FDG-PET images

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Young; Lee, Yong Ki; Ahn, Sung Min [Dept. of Radiological Science, Gachon University, Seongnam (Korea, Republic of)

    2017-06-15

    In addition to tumors, normal tissues, such as the brain and myocardium can intake {sup 18}F-FDG, and the amount of {sup 18}F-FDG intake by normal tissues can be altered by the surrounding environment. Therefore, a process is necessary during which the contrasts of the tumor and normal tissues can be enhanced. Thus, this study examines the effects of glucose levels on FDG PET images of brain tissues, which features high glucose activity at all times, in small animals. Micro PET scan was performed on fourteen mice after injecting {sup 18}F-FDG. The images were compared in relation to fasting. The findings showed that the mean SUV value w as 0 .84 higher in fasted mice than in non-fasted mice. During observation, the images from non-fasted mice showed high accumulation in organs other than the brain with increased surrounding noise. In addition, compared to the non-fasted mice, the fasted mice showed higher early intake and curve increase. The findings of this study suggest that fasting is important in assessing brain functions in brain PET using {sup 18}F-FDG. Additional studies to investigate whether caffeine levels and other preprocessing items have an impact on the acquired images would contribute to reducing radiation exposure in patients.

  11. Methodological considerations in quantification of oncological FDG PET studies.

    Science.gov (United States)

    Vriens, Dennis; Visser, Eric P; de Geus-Oei, Lioe-Fee; Oyen, Wim J G

    2010-07-01

    This review aims to provide insight into the factors that influence quantification of glucose metabolism by FDG PET images in oncology as well as their influence on repeated measures studies (i.e. treatment response assessment), offering improved understanding both for clinical practice and research. Structural PubMed searches have been performed for the many factors affecting quantification of glucose metabolism by FDG PET. Review articles and references lists have been used to supplement the search findings. Biological factors such as fasting blood glucose level, FDG uptake period, FDG distribution and clearance, patient motion (breathing) and patient discomfort (stress) all influence quantification. Acquisition parameters should be adjusted to maximize the signal to noise ratio without exposing the patient to a higher than strictly necessary radiation dose. This is especially challenging in pharmacokinetic analysis, where the temporal resolution is of significant importance. The literature is reviewed on the influence of attenuation correction on parameters for glucose metabolism, the effect of motion, metal artefacts and contrast agents on quantification of CT attenuation-corrected images. Reconstruction settings (analytical versus iterative reconstruction, post-reconstruction filtering and image matrix size) all potentially influence quantification due to artefacts, noise levels and lesion size dependency. Many region of interest definitions are available, but increased complexity does not necessarily result in improved performance. Different methods for the quantification of the tissue of interest can introduce systematic and random inaccuracy. This review provides an up-to-date overview of the many factors that influence quantification of glucose metabolism by FDG PET.

  12. {sup 18}F-FDG-PET/CT in Endometrial Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Tae Joo [Pochon CHA University College of Medicine, Sungnam (Korea, Republic of)

    2008-12-15

    Endometrial carcinoma is one of the most common gynecologic malignancies and which is predominant in postmenopausal women. Clinically many patients are hospitalized in early stage due to clinical sign and symptom such as vaginal bleeding and in this case, patient's prognosis is known to be good. However, considerable number of patients with advanced and relapsed disease reveal poor prognosis. Therefore, exact staging work up is essential for proper treatment as is primary lesion detection. {sup 18}F-FDG-PET has been widely used for the evaluation of gynecologic malignancies such as cervical carcinoma and ovarian cancer. In contrast, FDG PET application to endometrial carcinoma is limited until now and there is no sufficient data to validate the usefulness of FDG PET for this disease yet. However, several studies showed promising results that FDG PET is sensitive and specific in detection of recurrent or metastatic lesions. Therefore further active investigation in this field can facilitate the use of FDG PET for endometrial carcinoma.

  13. FDG-PET of autoimmune-related pancreatitis: preliminary results

    Energy Technology Data Exchange (ETDEWEB)

    Nakamoto, Yuji; Saga, Tsuneo; Ishimori, Takayoshi; Higashi, Tatsuya; Mamede, M.; Konishi, Junji [Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University (Japan); Okazaki, Kazuichi [Department of Endoscopy and Gastroenterology, Graduate School of Medicine, Kyoto University (Japan); Imamura, Masayuki [Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University (Japan); Sakahara, Harumi [Department of Radiology, Hamamatsu University School of Medicine (Japan)

    2000-12-01

    The purpose of this retrospective study was to elucidate the fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) findings in autoimmune-related pancreatitis (AIP), which is a reversible chronic pancreatitis with an autoimmune cause. The study group comprised six patients with clinically diagnosed AIP. After 370 MBq (10 mCi) of FDG had been injected intravenously, the abdomen and/or the whole body was scanned at 1 h post injection in all patients, and scanning was repeated at 2 h in four patients. PET findings were evaluated visually and/or semiquantitatively using the standardized uptake value (SUV). In four of the six patients, PET demonstrated intense uptake in the whole pancreas, which appeared swollen on computed tomography, and the accumulation increased with time in three patients. In one patient, intense focal uptake in the pancreatic head was observed, and the accumulation decreased over time. In the remaining patient, no abnormal accumulation in the pancreas was observed. Follow-up PET scanning after steroid therapy was performed in three patients, and intense FDG uptake was no longer observed. Our preliminary data show that AIP can cause intense FDG uptake in the pancreas. This fact, and the benign status of the condition, should be kept in mind when making a diagnosis with FDG-PET in patients with pancreatic disorders. (orig.)

  14. Au pair trajectories

    DEFF Research Database (Denmark)

    Dalgas, Karina Märcher

    2015-01-01

    Since 2000, thousands of young Filipino migrants have come to Denmark as au pairs. Officially, they are there to “broaden their cultural horizons” by living temporarily with a Danish host family, but they also conduct domestic labor in exchange for food and money, which allows them to send...

  15. Catalytic activity of Au nanoparticles

    DEFF Research Database (Denmark)

    Larsen, Britt Hvolbæk; Janssens, Ton V.W.; Clausen, Bjerne

    2007-01-01

    Au is usually viewed as an inert metal, but surprisingly it has been found that Au nanoparticles less than 3–5 nm in diameter are catalytically active for several chemical reactions. We discuss the origin of this effect, focusing on the way in which the chemical activity of Au may change with par......Au is usually viewed as an inert metal, but surprisingly it has been found that Au nanoparticles less than 3–5 nm in diameter are catalytically active for several chemical reactions. We discuss the origin of this effect, focusing on the way in which the chemical activity of Au may change...... with particle size. We find that the fraction of low-coordinated Au atoms scales approximately with the catalytic activity, suggesting that atoms on the corners and edges of Au nanoparticles are the active sites. This effect is explained using density functional calculations....

  16. Location of recurrent groin hernias at TEP after Lichtenstein repair: a study based on the Swedish Hernia Register.

    Science.gov (United States)

    Bringman, S; Holmberg, H; Österberg, J

    2016-06-01

    To investigate which type of hernia that has the highest risk of a recurrence after a primary Lichtenstein repair. Male patients operated on with a Lichtenstein repair for a primary direct or indirect inguinal hernia and with a TEP for a later recurrence, with both operations recorded in the Swedish Hernia Register (SHR), were included in the study. The study period was 1994-2014. Under the study period, 130,037 male patients with a primary indirect or direct inguinal hernia were operated on with a Lichtenstein repair. A second operation in the SHR was registered in 2236 of these patients (reoperation rate 1.7 %). TEP was the chosen operation in 737 in this latter cohort. The most likely location for a recurrence was the same as the primary location. If the recurrences change location from the primary place, we recognized that direct hernias had a RR of 1.51 to having a recurrent indirect hernia compared to having a direct recurrence after an indirect primary hernia repair. Recurrent hernias after Lichtenstein are more common on the same location as the primary one, compared to changing the location.

  17. 18FDG PET and ultrasound echolucency in carotid artery plaques

    DEFF Research Database (Denmark)

    Graebe, Martin; Pedersen, Sune F; Højgaard, Liselotte

    2010-01-01

    OBJECTIVES: The objective was to evaluate inflammation in echolucent carotid artery plaques. BACKGROUND: Ultrasound echolucency of carotid artery plaques has been proven to differentiate patients at high risk of stroke. On the other hand, positron emission tomography (PET) of plaques with the use...... for ultrasound and PET imaging. Plaque standardized gray scale medians (GSM) were measured in longitudinal ultrasound images to quantitate echolucency, and GSM values were compared with FDG PET uptake quantified by maximum standardized uptake values (SUV). Symptomatic plaques were compared with contralateral...... plaques ranged from high to low inflammatory activity, as depicted with PET. Quantitative FDG SUV differentiated asymptomatic from symptomatic plaques, whereas GSM values did not. There was a positive correlation between CD68 expression and FDG uptake (r = 0.50, p = 0.04). CONCLUSIONS: Our results...

  18. FDG/PET uptake in asymptomatic multilobar Chlamydia pneumoniae pneumonia.

    Science.gov (United States)

    Bianco, Andrea; Mazzarella, Gennaro; Rocco, Danilo; Gasperi, Maurizio; Di Marco, Roberto; Brunese, Luca

    2010-06-01

    FDG-PET is a diagnostic imaging procedure effective in staging primary and recurrent cancer. False-positive uptake already has been described in both inflammatory and infectious respiratory diseases, although no reports associate Chlamydia pneumoniae infection to FDG uptake. An incidental diagnosis of asymptomatic multilobar pneumonia during screening for thyroid malignancy is reported. Three areas of pulmonary consolidation strongly positive on PET/CT scan, mimicking pulmonary malignancy were identified. Both radiologic features and serum IgM antibodies for Chlamydia pneumoniae suggested the diagnosis of an unusual presentation of a Chlamydia pneumoniae respiratory infection. Specific antibiotic therapy induced a complete resolution of the areas of pulmonary consolidation. This case suggests that positive PET is not an absolute indicator for malignancy. Chlamydia pneumoniae respiratory infections can exhibit positive uptake on FDG-PET.

  19. Prospective randomized clinical trial of Jean Rives technique versus laparoscopic TEP repair for primary inguinal hernia: 10-year follow-up.

    Science.gov (United States)

    Tomaoglu, K; Sarı, Y S; Bektas, H; Koc, O; Gunes, E; Uzum, G; Kucukyılmaz, M

    2015-06-01

    The purpose of the present randomized trial was to compare the Jean Rives (JR) technique and the laparoscopic totally extraperitoneal (TEP) repair for the treatment of primary inguinal hernias with respect to operating time, hospital stay, sick leave, chronic pain and recurrences after a follow-up of 10 years. 110 patients with primary inguinal hernia were randomized to either a JR repair (53 patients) or to a laparoscopic (TEP) repair (57 patients). All the interventions were exclusively realized by two experienced surgeons. Follow-up examinations were performed after 1, 6 months, 1, 5 and 10 years. Both groups were identical concerning age and hernia type, which were type II and type IIIa according to Nyhus classification. No significant difference was found concerning hospital stay, chronic pain and recurrences. The operating time was significantly lower in JR group, whereas the sick leave was significantly in favor of TEP group. Jean Rives technique is a relatively easy technique to perform, requires shorter operating time when compared to laparoscopic TEP technique. JR technique should be taken into consideration while planning surgical treatment of inguinal hernia.

  20. Earth Observation-Supported Service Platform for the Development and Provision of Thematic Information on the Built Environment - the Tep-Urban Project

    Science.gov (United States)

    Esch, T.; Asamer, H.; Boettcher, M.; Brito, F.; Hirner, A.; Marconcini, M.; Mathot, E.; Metz, A.; Permana, H.; Soukop, T.; Stanek, F.; Kuchar, S.; Zeidler, J.; Balhar, J.

    2016-06-01

    The Sentinel fleet will provide a so-far unique coverage with Earth observation data and therewith new opportunities for the implementation of methodologies to generate innovative geo-information products and services. It is here where the TEP Urban project is supposed to initiate a step change by providing an open and participatory platform based on modern ICT technologies and services that enables any interested user to easily exploit Earth observation data pools, in particular those of the Sentinel missions, and derive thematic information on the status and development of the built environment from these data. Key component of TEP Urban project is the implementation of a web-based platform employing distributed high-level computing infrastructures and providing key functionalities for i) high-performance access to satellite imagery and derived thematic data, ii) modular and generic state-of-the art pre-processing, analysis, and visualization techniques, iii) customized development and dissemination of algorithms, products and services, and iv) networking and communication. This contribution introduces the main facts about the TEP Urban project, including a description of the general objectives, the platform systems design and functionalities, and the preliminary portfolio products and services available at the TEP Urban platform.

  1. F-18 FDG uptake in respiratory muscle mimicking metastasis in patients with gastric cancer

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Seung Jin; Hyun, In Young [Inha University College of Medicine, Incheon (Korea, Republic of); Kim, Jeong Ho [Gachon Medical School Gil Medical Center, Incheon (Korea, Republic of)

    2006-08-15

    A 67-year-old man with a history of chronic obstructive pulmonary disease (COPD) underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for staging of gastric cancer. The projection images of F-18 FDG PET/CT showed intensely increased F-18 FDG uptake in the anterior neck, chest wall, and upper abdomen. We suspected distant metastases of cervical lymph nodes, ribs, and peritoneum in gastric cancer. However, the transaxial images of F-18 FDG PET/CT showed abnormal F-18 FDG uptake in scalene muscles of anterior neck, intercostal muscles of chest wall, and diaphragm of upper abdomen. Patients with COPD use respiratory muscles extensively on the resting condition. These excessive physiologic use of respiratory muscles causes increased F-18 FDG uptake as a result of increased glucose metabolism. The F-18 FDG uptake in respiratory muscles of gastric cancer patient with COPD mimicked distant metastases in cervical lymph nodes, ribs, and peritoneum.

  2. Ophthalmologic abnormalities on FDG-PET/CT: a pictorial essay.

    Science.gov (United States)

    Muzaffar, Razi; Shousha, Mohamed A; Sarajlic, Lejla; Osman, Medhat M

    2013-03-21

    Positron emission tomography (PET) using [(18)F]-2-deoxy-d-glucose (FDG) diagnoses, stages, and restages many cancers and is often better than anatomic imaging alone. However, abnormalities within the orbit present a challenge in evaluation, mainly due to the subtle findings on PET/computed tomography (CT). In addition, this region is typically at the edge of the field of view for the standard base of skull to upper thigh FDG-PET/CT scans. The aim of this pictorial essay is to illustrate several subtle and apparent abnormalities within the orbit that can have a profound impact on patient management and follow-up.

  3. FDG at 7.8 MeV

    DEFF Research Database (Denmark)

    Jensen, Mikael

    2017-01-01

    I here report the fundamental performance of a new generation of compact medical cyclotrons for hospital-based PET tracer manufacture, exemplified with the FDG production numbers achieved by the first prototype of the GE GenTrace cyclotron. The proton energy is 7.8 MeV. After 3 years of extensive...... testing in a "physics lab" setting, which is door-to-door with our normal GMP production suite, I can now conclude that this cyclotron in conjunction with a standard GE Fastlab chemistry box easily achieves significant, reliable and compliant FDG output surpassing 15 GBq per batch at EOS, after 2 hours...

  4. Experimental evidence of formation of transparent exopolymer particles (TEP) and POC export provoked by dust addition under current and high pCO2 conditions.

    Science.gov (United States)

    Louis, Justine; Pedrotti, Maria Luiza; Gazeau, Frédéric; Guieu, Cécile

    2017-01-01

    The evolution of organic carbon export to the deep ocean, under anthropogenic forcing such as ocean warming and acidification, needs to be investigated in order to evaluate potential positive or negative feedbacks on atmospheric CO2 concentrations, and therefore on climate. As such, modifications of aggregation processes driven by transparent exopolymer particles (TEP) formation have the potential to affect carbon export. The objectives of this study were to experimentally assess the dynamics of organic matter, after the simulation of a Saharan dust deposition event, through the measurement over one week of TEP abundance and size, and to evaluate the effects of ocean acidification on TEP formation and carbon export following a dust deposition event. Three experiments were performed in the laboratory using 300 L tanks filled with filtered seawater collected in the Mediterranean Sea, during two 'no bloom' periods (spring at the start of the stratification period and autumn at the end of this stratification period) and during the winter bloom period. For each experiment, one of the two tanks was acidified to reach pH conditions slightly below values projected for 2100 (~ 7.6-7.8). In both tanks, a dust deposition event of 10 g m-2 was simulated at the surface. Our results suggest that Saharan dust deposition triggered the abiotic formation of TEP, leading to the formation of organic-mineral aggregates. The amount of particulate organic carbon (POC) exported was proportional to the flux of lithogenic particles to the sediment traps. Depending on the season, the POC flux following artificial dust deposition ranged between 38 and 90 mg m-2 over six experimental days. Such variability is likely linked to the seasonal differences in the quality and quantity of TEP-precursors initially present in seawater. Finally, these export fluxes were not significantly different at the completion of the three experiments between the two pH conditions.

  5. Mise au point

    African Journals Online (AJOL)

    31 mai 2013 ... laryngocèle interne. Une surinfection a été notée chez trois patients réalisant ainsi le tableau de pyolaryngocèle. Tous les patients ont eu un examen clinique complet comportant un examen OrL et cervico-facial ainsi qu'un examen laryngé au ... pas en communication avec la lumière laryngée. La taille.

  6. Le CRDI au Mali

    International Development Research Centre (IDRC) Digital Library (Canada)

    sur la sécurité alimentaire internationale. Le CRDI continue de soutenir des travaux de recherche au Mali, quoique dans une moindre mesure en raison de la .... souvent tenues à l'écart du processus décisionnel. Les chercheurs tentent de déterminer de quelles manières les jeunes femmes du Mali et des pays avoisinants ...

  7. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... Le carcinome folliculaire est la deuxième tumeur maligne la plus fréquente de la thyroïde et l'invasion hématologique est le moyen de propagation le plus courant de ses métastases. Les localisations secondaires à ces cancers siègent principalement au niveau des poumons, suivi par les localisations.

  8. Le CRDI au Maroc

    International Development Research Centre (IDRC) Digital Library (Canada)

    visant à aider les secteurs de l'agriculture et du tourisme à s'adapter aux changements climatiques. Dans le cadre de recherches antérieures sur la mise au point .... France. Les manifestations et protestations survenues après 2010 et auxquelles on a donné le nom de Printemps arabe ont été annonciatrices de profondes ...

  9. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... EPIdEMIOlOgIE ET ETIOPAThOgENIE. Les angiodysplasies osseuses des maxillaires sont rares. Les premiers cas rapportés sont ceux de Berard qui a décrit en 1842 une localisation au niveau du maxillaire supérieur et de Stanley qui a rapporté en 1849 une loca- lisation mandibulaire. une prédisposition ...

  10. Le CRDI au Kenya

    International Development Research Centre (IDRC) Digital Library (Canada)

    et de l'agriculture. En produisant des connaissances dans ces secteurs essentiels, le programme contribuera à la sécurité alimentaire et améliorera la santé au Kenya. Les noms et les frontières indiqués sur la carte n'impliquent ni reconnaissance ni acceptation officielle de la part du CRDI. C. U. R. T. C. A. R. N. EM. A. R. K.

  11. FDG-PET Contributions to the Pathophysiology of Memory Impairment.

    Science.gov (United States)

    Segobin, Shailendra; La Joie, Renaud; Ritz, Ludivine; Beaunieux, Hélène; Desgranges, Béatrice; Chételat, Gaël; Pitel, Anne Lise; Eustache, Francis

    2015-09-01

    Measurement of synaptic activity by Positron Emission Tomography (PET) and its relation to cognitive functions such as episodic memory, working memory and executive functions in healthy humans and patients with neurocognitive disorders have been well documented. In this review, we introduce the concept of PET imaging that allows the observation of a particular biological process in vivo through the use of radio-labelled compounds, its general use to the medical world and its contributions to the understanding of memory systems. We then focus on [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG-PET), the radiotracer that is used to measure local cerebral metabolic rate of glucose that is indicative of synaptic activity in the brain. FDG-PET at rest has been at the forefront of functional neuroimaging over the past 3 decades, contributing to the understanding of cognitive functions in healthy humans and how these functional patterns change with cognitive alterations. We discuss methodological considerations that are important for optimizing FDG-PET imaging data prior to analysis. We then highlight the contribution of FDG-PET to the understanding of the patterns of functional differences in non-degenerative pathologies, normal ageing, and age-related neurodegenerative disorders. Through reasonable temporal and spatial resolution, its ability to measure synaptic activity in the whole brain, independently of any specific network and disease, makes it ideal to observe regional functional changes associated with memory impairment.

  12. Methodological considerations in quantification of oncological FDG PET studies.

    NARCIS (Netherlands)

    Vriens, D.; Visser, E.P.; Geus-Oei, L.F. de; Oyen, W.J.G.

    2010-01-01

    PURPOSE: This review aims to provide insight into the factors that influence quantification of glucose metabolism by FDG PET images in oncology as well as their influence on repeated measures studies (i.e. treatment response assessment), offering improved understanding both for clinical practice and

  13. Lymphomatoid Granulomatosis: CT and FDG-PET Findings

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Jonathan H. [National Jewish Health, Denver (United States); Wu, Carol C.; Gilman, Matthew D.; Palmer, Edwin L.; Hasserjian, Robert P.; Sphepar, Jo-Anne O. [Massachusetts General Hospital, Boston (United States)

    2011-11-15

    Lymphomatoid granulomatosis (LG) is a rare, aggressive extranodal Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disease. The purpose of our study was to analyze the CT and fluorodeoxyglucose positron emission tomography (FDG-PET) findings of pulmonary LG. Between 2000 and 2009, four patients with pathologically proven pulmonary LG and chest CT were identified. Two of these patients also had FDG-PET. Imaging features of LG on CT and PET were reviewed. Pulmonary nodules or masses with peribronchovascular, subpleural, and lower lung zonal preponderance were present in all patients. Central low attenuation (4 of 4 patients), ground-glass halo (3 of 4 patients), and peripheral enhancement (4 of 4 patients) were observed in these nodules and masses. An air-bronchogram and cavitation were seen in three of four patients. FDG-PET scans demonstrated avid FDG uptake in the pulmonary nodules and masses. Pulmonary LG presents with nodules and masses with a lymphatic distribution, as would be expected for a lymphoproliferative disease. However, central low attenuation, ground-glass halo and peripheral enhancement of the nodules/masses are likely related to the angioinvasive nature of this disease. Peripheral enhancement and ground-glass halo, in particular, are valuable characteristic not previously reported that can help radiologists suggest the diagnosis of pulmonary LG.

  14. Pleural FDG Uptake More Than a Decade after Talc Pleurodesis

    NARCIS (Netherlands)

    Peek, H.; Bruggen, W. van der; Limonard, G.

    2009-01-01

    Talc pleurodesis induces a strong local inflammatory reaction which can be detected by PET scan for years after the procedure. When patients undergo PET scanning in the workup of a suspected malignancy later in life, pleural FDG uptake may unnecessarily lead to an additional invasive diagnostic

  15. Anakinra Injection Site Reaction on FDG PET/CT

    NARCIS (Netherlands)

    Arens, A.I.J.; Vriens, D.; Janssen, M; Simon, A.; Oyen, W.J.G.

    2015-01-01

    Adult-onset Still's disease (AOSD) is a rare inflammatory disorder of unknown etiology, mainly characterized by fever, arthritis, skin rash, and raised ferritin concentration. FDG PET/CT scan of a 29-year-old woman with AOSD showed extensive lymphadenopathy, hypermetabolic splenomegaly, and

  16. [Interest of FDG-PET for lung cancer radiotherapy].

    Science.gov (United States)

    Thureau, S; Mezzani-Saillard, S; Modzelewski, R; Edet-Sanson, A; Dubray, B; Vera, P

    2011-10-01

    The recent advances in medical imaging have profoundly altered the radiotherapy of non-small cell lung cancers (NSCLC). A meta-analysis has confirmed the superiority of FDG PET-CT over CT for initial staging. FDG PET-CT improves the reproducibility of target volume delineation, especially close to the mediastinum or in the presence of atelectasia. Although not formally validated by a randomized trial, the reduction of the mediastinal target volume, by restricting the irradiation to FDG-avid nodes, is widely accepted. The optimal method of delineation still remains to be defined. The role of FDG PET-CT in monitoring tumor response during radiotherapy is under investigation, potentially opening the way to adapting the treatment modalities to tumor radiation sensitivity. Other tracers, such as F-miso (hypoxia), are also under clinical investigation. To avoid excessive delays, the integration of PET-CT in routine practice requires quick access to the imaging equipment, technical support (fusion and image processing) and multidisciplinary delineation of target volumes. Copyright © 2011 Société française de radiothérapie oncologique (SFRO). Published by Elsevier SAS. All rights reserved.

  17. Multicentric evaluation by Verbal Rate Scale and EuroQoL-5D of early and late post-operative pain after TAPP and TEP procedures with mechanical fixation for bilateral inguinal hernias.

    Science.gov (United States)

    Zanghì, Antonio; Di Vita, Maria; Lo Menzo, Emanuele; Castorina, Sergio; Cavallaro, Andrea Sebastiano; Piccolo, Gaetano; Grosso, Giuseppe; Cappellani, Alessandro

    2011-01-01

    Aimed to evaluate the postoperative pain and other complications among two cohorts of patients undergone transabdominal preperitoneal (TAPP) and totally extraperitoneal (TEP) laparoscopic hernia repairs with mechanical fixation, the chart of 305 TAPP and 134 TEP for bilateral not recurrent inguinal hernias were reviewed. The postoperative pain was assessed by using the Verbal Rating Scale (VRS) at one week, one month, 3 months ad six months postoperatively. A subgroup of 60 patients was also administered the QoL EQ-5D questionnaire and follow up for at least 6 months. We found a statistically significant difference in the first day (p = 0.001), in the 7th day (p = 0.002), 30th, and 90th day (p = 0.008) between patients perception of pain in TAPP group and TEP group, but after the 180th day there was not any considerable distinction. On the short term the postoperative pain seems slightly lesser in TEP group.

  18. Clinical Impact of a Second FDG-PET in Atypical/Unclear Dementia Syndromes.

    Science.gov (United States)

    Bergeron, David; Beauregard, Jean-Mathieu; Guimond, Jean; Fortin, Marie-Pierre; Houde, Michèle; Poulin, Stéphane; Verret, Louis; Bouchard, Rémi W; Laforce, Robert

    2016-01-01

    Diagnosis of atypical/unclear dementia is often difficult and this delays treatment initiation. Several authors have shown that beyond standard dementia workup, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) reduces the number of unclear diagnoses, leads to earlier treatment, and has a beneficial impact on families. However, it is not uncommon that the FDG-PET findings are equivocal in this setting. For those cases, a repeat FDG-PET may clarify the diagnosis and prevent treatment delay. We retrospectively assessed the clinical impact of a repeat FDG-PET in 59 patients with atypical/unclear dementia syndromes and inconclusive initial FDG-PET. Changes in primary diagnosis, diagnostic confidence, and management following the second FDG-PET were examined. Conducting a second FDG-PET reduced the number of unclear diagnoses from 80% to 34% , led to diagnostic change in 24% of cases, and treatment modification in 22% of patients. Overall, the clinical impact was higher when initial diagnostic confidence was low and the second FDG-PET repeated ≥12 months after the first one. In tertiary care memory clinic settings, when diagnostic incertitude persists despite extensive evaluation and an equivocal FDG-PET, repeating the FDG-PET 12 months later can greatly clarify the diagnosis and improve management.

  19. Methodological considerations in quantification of oncological FDG PET studies

    Energy Technology Data Exchange (ETDEWEB)

    Vriens, Dennis; Visser, Eric P.; Geus-Oei, Lioe-Fee de; Oyen, Wim J.G. [Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, Nijmegen (Netherlands)

    2010-07-15

    This review aims to provide insight into the factors that influence quantification of glucose metabolism by FDG PET images in oncology as well as their influence on repeated measures studies (i.e. treatment response assessment), offering improved understanding both for clinical practice and research. Structural PubMed searches have been performed for the many factors affecting quantification of glucose metabolism by FDG PET. Review articles and references lists have been used to supplement the search findings. Biological factors such as fasting blood glucose level, FDG uptake period, FDG distribution and clearance, patient motion (breathing) and patient discomfort (stress) all influence quantification. Acquisition parameters should be adjusted to maximize the signal to noise ratio without exposing the patient to a higher than strictly necessary radiation dose. This is especially challenging in pharmacokinetic analysis, where the temporal resolution is of significant importance. The literature is reviewed on the influence of attenuation correction on parameters for glucose metabolism, the effect of motion, metal artefacts and contrast agents on quantification of CT attenuation-corrected images. Reconstruction settings (analytical versus iterative reconstruction, post-reconstruction filtering and image matrix size) all potentially influence quantification due to artefacts, noise levels and lesion size dependency. Many region of interest definitions are available, but increased complexity does not necessarily result in improved performance. Different methods for the quantification of the tissue of interest can introduce systematic and random inaccuracy. This review provides an up-to-date overview of the many factors that influence quantification of glucose metabolism by FDG PET. (orig.) 3.

  20. Influence of type of mesh fixation in endoscopic totally extraperitoneal hernia repair (TEP) on long-term quality of life.

    Science.gov (United States)

    Horisberger, K; Jung, M K; Zingg, U; Schöb, O

    2013-06-01

    Laparoscopic total extraperitoneal mesh repair (TEP) of inguinal hernia has become well accepted with low recurrence and high patient satisfaction rates. However, inguinal pain has also been reported. Source of this pain has been suggested to be the fixation method, especially the use of tacks. Introduction of fibrin glue and absorbable tacks were suggested to lower chronic pain and inguinal discomfort rates. This study analyses the different methods of fixation. 201 patients were analysed. Primary end-points were patients' satisfaction, health-related quality of life, and specific inguinal conditions (e.g. pulling, swelling, troubles at coughing). Secondary endpoints were duration of operation, length of hospital stay, and material costs. Fibrin glue was used in 101 patients and tacks in 100 patients, in 21 of those absorbable tacks. Patients were fully satisfied with the results in more than 90%, irrespective of the fixation method. Health-related quality of life along the SF-12(®) questionnaire attested no differences. Inguinal pulling occurred significantly more often after fibrin glue (25.7 %) than after tack fixation (11 %; p = 0.026), whereas no differences in the other specific inguinal sensations occurred. Mesh fixation in TEP can be performed either by tacks or by fibrin glue with similar long-term results concerning satisfaction, health-related quality of life, and pain. No advantage of fibrin glue could be found, in fact, a higher percentage of patients had inguinal pulling and burning sensations after the use of fibrin glue. The use of absorbable tacks showed no advantage.

  1. Bacterial Colonization and Vertical Distribution of Marine Gel Particles (TEP and CSP in the Arctic Fram Strait

    Directory of Open Access Journals (Sweden)

    Kathrin Busch

    2017-06-01

    Full Text Available Gel particles—a class of abundant transparent organic particles—have increasingly gathered attention in marine research. Field studies on the bacterial colonization of marine gels however are still scarce. So far, most studies on respective particles have focused on the upper ocean, while little is known on their occurrence in the deep sea. Here, we report on the vertical distribution of the two most common gel particle types, which are polysaccharide-containing transparent exopolymer particles (TEP and proteinaceous Coomassie stainable particles (CSP, as well as numbers of bacteria attached to gel particles throughout the water column, from the surface ocean down to the bathypelagial (< 3,000 m. Our study was conducted in the Arctic Fram Strait during northern hemispheres' summer in 2015. Besides data on the bacterial colonization of the two gel particle types (TEP and CSP, we present bacterial densities on different gel particle size classes according to 12 different sampling depths at four sampling locations. Gel particles were frequently abundant at all sampled depths, and their concentrations decreased from the euphotic zone to the dark ocean. They were colonized by bacteria at all sampled water depths with risen importance at the deepest water layers, where fractions of bacteria attached to gel particles (% increased within the total bacterial community. Due to the omnipresent bacterial colonization of gel particles at all sampled depths in our study, we presume that euphotic production of this type of organic matter may affect microbial species distribution within the whole water column in the Fram Strait, down to the deep sea. Our results raise the question if changes in the bacterial community composition and functioning on gel particles occur over depth, which may affect microbial respiration and remineralization rates of respective particles in different water layers.

  2. Paclitaxel, epirubicin, and cisplatin (TEP) regimen as neoadjuvant treatment in locally advanced cervical cancer: long-term results.

    Science.gov (United States)

    Ferrandina, G; Distefano, M G; De Vincenzo, R; Salutari, V; Petrillo, M; Scarciglia, M L; Pietragalla, A; Conte, C; Scambia, G

    2013-03-01

    We evaluated the rates of response, operability and long term survival and toxicities in a large series of locally advanced cervical cancer (LACC) patients administered neoadjuvant chemotherapy (NACT) with paclitaxel, epirubicin and cisplatin (TEP) followed by radical surgery (RS). Patients and methods The study included 75 consecutive stages IB2-IVA patients administered NACT with paclitaxel (175mg/m(2)), epirubicin (100mg/m(2)) and cisplatin (100mg/m(2)) on day 1 of a 3-weekly cycle for 2-4cycles. Patients were evaluated for objective response by RECIST criteria and triaged to RS. Progression-free survival (PFS) and overall survival (OS) were calculated from the date of diagnosis to recurrence/progression of disease or death, respectively. Complete and partial clinical response was observed in 13 and 28 patients (56.1% objective responses); radical surgery was amenable in 52 patients (71.2%): 14 patients showed complete/microscopic response to treatment. Overall, recurrence/progression of disease was observed in 36 patients, and all of them experienced death of disease. In the whole series median PFS was 48months (5-year PFS=51.0%), and median OS was 72months (5-year OS=53.0%). Overall, 195 courses were administered; treatment was delayed in 6.7% of patients, while dose reduction was required in 36.5% of patients. Grade 3 leukopenia affected 22 patients (29.7%), while Grades 3 and 4 neutropenia was documented in 17 (22.9%) and 6 (8.1%) patients. In the whole series, we recorded 1 death whose relation with treatment-induced toxicity could not be ruled out. TEP provided favorable rates of response and operability in LACC patients, and allowed the obtainment of encouraging survival data without carrying out an excessive toxicity. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. Mise au point

    African Journals Online (AJOL)

    31 mai 2013 ... L'attitude théra- peutique dépend du type de la laryngocèle. en effet, le traitement endoscopique au laser CO2 a gagné beaucoup d'intérêt ces dernières années. MATÉRIEL ET MÉTHOdES. Il s'agit d'une étude rétrospective portant sur 9 patients porteurs d'une laryngocèle colligés sur une période de 14.

  4. Le CRDI au Ghana

    International Development Research Centre (IDRC) Digital Library (Canada)

    poussée en mathématiques aux spécialistes de demain afin qu'ils puissent relever les défis pressants qui se posent en matière d'environnement, de santé et d'économie. La bourse de chercheur invité que le CRDI a octroyée en 2001 au regretté. John Atta-Mills, qui a par la suite été prési- dent du Ghana de 2009 à 2012, ...

  5. Au pairs on Facebook

    DEFF Research Database (Denmark)

    Dalgas, Karina Märcher

    2016-01-01

    Ethnographers are increasingly making use of Facebook to acquire access and general acquaintance with their field of study. However, little has been written on how Facebook is used methodologically in research that does not have social media sites as the main focus of interest. This article argues...... that engagement with Facebook as a methodological tool can be useful in research among migrants in highly politicised fields. Pointing to a discursive construction of Filipina au pairs as victims of labour exploitation, the article shows how fieldwork on Facebook enables the exploration of the ways in which...... and on Facebook....

  6. Mise au point

    African Journals Online (AJOL)

    7 mai 2012 ... acquis et des anomalies génétiques associées ont été aussi incriminés (mutation du gène Fas ou de la p53, délétion au niveau du chromosome 6q, méthylation excessive de la p73) (15,16). Le mode de révélation de ces lymphomes est peu spéci- fique et parfois banal. L'obstruction nasale représente le.

  7. sarcome d'ewing

    African Journals Online (AJOL)

    7 mai 2012 ... TEp/TDM au FDg-18F apparaît plus sensible que la scintigraphie osseuse pla- naire et tomographique aux bisphosphonates-99mTc dans la récidive du sarco- me d'Ewing à localisations ostéomédullaires. À propos d'une observation de sar- come d'Ewing à localisation initiale mandibulaire et récidive ...

  8. Cancer-associated stroma affects FDG uptake in experimental carcinomas. Implications for FDG-PET delineation of radiotherapy target

    Energy Technology Data Exchange (ETDEWEB)

    Farace, Paolo; Merigo, Flavia; Galie, Mirco; Sbarbati, Andrea; Marzola, Pasquina [University of Verona, Department of Morphological-Biomedical Sciences, Section of Anatomy and Histology, Verona (Italy); D' Ambrosio, Daniela; Nanni, Cristina; Spinelli, Antonello; Fanti, Stefano [Policlinico ' S. Orsola-Malpighi' , Department of Nuclear Medicine, Bologna (Italy); Degrassi, Anna [Nerviano Medical Sciences, Milan (Italy); Rubello, Domenico [' S. Maria della Misericordia' Hospital, PET Centre, Department of Nuclear Medicine, Rovigo (Italy)

    2009-04-15

    To analyse the influence of cancer-associated stroma on FDG-uptake in two carcinoma models characterized by different stromal degrees. Eight nude mice were subcutaneously injected with DU-145 prostate cancer cells or BXPC-3 pancreatic cancer cells, and underwent FDG-PET imaging about 2 weeks after implantation. After the mice were killed, histology, and CD31 and GLUT1 immunohistochemistry were performed. To further evaluate the highly stromalized carcinoma using perfusion-sensitive imaging, four BXPC-3 tumours underwent two successive albumin-binding (MS-325) MRI scans during tumour growth. FDG uptake was significantly higher in the DU-145 than in the BXPC-3 tumours, which were hardly distinguishable from adjacent normal tissue. In the BXPC-3 tumours, histology confirmed the widespread presence of aberrant infiltrated stroma, embedded with numerous vessels marked by CD31. In both tumour types, the stromal matrix was negative for GLUT1. In DU-145 tumour cells, GLUT1 immunostaining was greater than in BXPC-3 tumour cells, but not homogeneously, since it was less evident in the tumour cells which were nearer to vessels and stroma. Finally, MS-325 MRI always clearly showed areas of enhancement in the BXPC-3 tumours. Cancer-associated stroma has been reported to be capable of aerobic metabolism with low glucose consumption. Furthermore, it has been proposed that regions with high vascular perfusion exhibit a significantly lower FDG uptake, suggesting some vascular/metabolic reciprocity. Since our results are consistent with these recent findings, they signal a risk of tumour volume underestimation in radiotherapy if FDG uptake alone is used for target delineation of carcinomas, which suggests that additional evaluation should be performed using vasculature/perfusion-sensitive imaging. (orig.)

  9. Assessment of atherosclerotic plaque inflammation can be improved by delayed time point FDG PET CT imaging

    DEFF Research Database (Denmark)

    Blomberg, Björn; Thomassen, Anders; Hildebrandt, Malene

    2013-01-01

    Objectives: Blood pool FDG activity can cloud the atherosclerotic plaque FDG signal. Over time, blood pool FDG activity declines. Therefore, delayed time point FDG PET CT imaging can potentially enhance the assessment of atherosclerotic plaque inflammation. Methods: Twelve healthy volunteers...... without traditional cardiovascular risk factors and three subjects with angina pectoris were prospectively assessed by dual time point 18-FDG PET CT imaging at 90 and 180 minutes after tracer injection. The ratio between aortic SUVmax and the blood pool SUVmean (TBR) was calculated to show the change......,35; df = 12; P = 0.037). Conclusions: Based on these preliminary data, we can make three conclusions: 1) aging and male gender are significantly correlated to atherosclerotic plaque FDG avidity, 2) over time, a significant increase is observed in TBR, and 3) the increase in cSUV over time results...

  10. Charged particle density distributions in Au+ Au collisions at ...

    Indian Academy of Sciences (India)

    ... measured in Au + Au collisions using the BRAHMS detector at RHIC. The results are presented as a function of the collision centrality and the center of mass energy. They are compared to the predictions of different parton scattering models and the important role of hard scattering processes at RHIC energies is discussed ...

  11. Incidental thyroid lesions detected by FDG-PET/CT: prevalence and risk of thyroid cancer

    Directory of Open Access Journals (Sweden)

    Kim Sung

    2009-08-01

    Full Text Available Abstract Background Incidentally found thyroid lesions are frequently detected in patients undergoing FDG-PET/CT. The aim of this study was to investigate the prevalence of incidentally found thyroid lesions in patients undergoing FDG-PET/CT and determine the risk for thyroid cancer. Methods FDG-PET/CT was performed on 3,379 patients for evaluation of suspected or known cancer or cancer screening without any history of thyroid cancer between November 2003 and December 2005. Medical records related to the FDG-PET/CT findings including maximum SUV(SUVmax and pattern of FDG uptake, US findings, FNA, histopathology received by operation were reviewed retrospectively. Results Two hundred eighty five patients (8.4% were identified to have FDG uptake on FDG-PET/CT. 99 patients with focal or diffuse FDG uptake underwent further evaluation. The cancer risk of incidentally found thyroid lesions on FDG-PET/CT was 23.2% (22/99 and the cancer risks associated with focal and diffuse FDG uptake were 30.9% and 6.4%. There was a significant difference in the SUVmax between the benign and malignant nodules (3.35 ± 1.69 vs. 6.64 ± 4.12; P max and the size of the cancer. Conclusion The results of this study suggest that incidentally found thyroid lesions by FDG-PET/CT, especially a focal FDG uptake and a high SUV, have a high risk of thyroid malignancy. Further diagnostic work-up is needed in these cases.

  12. (18)F-FDG PET/CT Findings in a Patient with Chikungunya Virus Infection

    DEFF Research Database (Denmark)

    Rose, Michala Vaaben; Kjaer, Anna Sophie L; Markova, Elena

    2017-01-01

    We present a case demonstrating the diagnostic work-up and follow-up of a patient with Chikungunya infection. An (18)F-FDG PET/CT performed four weeks after debut of symptoms revealed pathological (18)F-FDG uptake in enlarged lymph nodes on both side of the diaphragm, and inflammation of both...... sequential (18)F-FDG PET/CT scan results in a patient with Chikungunya virus infection....

  13. Incremental diagnostic utility of gastric distension FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Le Roux, Pierre-Yves [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia); Brest University Hospital, Department of Nuclear Medicine, Brest (France); Duong, Cuong P.; Cabalag, Carlos S. [Peter MacCallum Cancer Centre, Department of Surgical Oncology, East Melbourne, VIC (Australia); Parameswaran, Bimal K.; Callahan, Jason [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia); Hicks, Rodney J. [Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne (Australia); The University of Melbourne, Parkville (Australia)

    2016-04-15

    To assess the diagnostic utility of gastric distension (GD) FDG PET/CT in both patients with known gastric malignancy and those not known to have gastric malignancy but with incidental focal FDG uptake in the stomach. This retrospective analysis included 88 patients who underwent FDG PET/CT following GD with hyoscine N-butylbromide (Buscopan registered) and water ingestion as part of routine clinical evaluation between 2004 and 2014. FDG PET/CT scans before and after GD were reported blinded to the patient clinical details in 49 patients undergoing pretreatment staging of gastric malignancy and 39 patients who underwent GD following incidental suspicious gastric uptake. The PET findings were validated by a composite clinical standard. In the 49 patients undergoing pretreatment staging of gastric malignancy, GD improved PET detection of the primary tumour (from 80 % to 90 %). PET evaluation of tumour extent was concordant with endoscopic/surgical reports in 31 % (interpreter 1) and 45 % (interpreter 2) using pre-GD images and 73 % and 76 % using GD images. Interobserver agreement also improved with GD (κ = 0.29 to 0.69). Metabolic and morphological quantitative analysis demonstrated a major impact of GD in normal gastric wall but no significant effect in tumour, except a minor increase in SUV related to a delayed acquisition time. The tumour to normal stomach SUVmax ratio increased from 3.8 ± 2.9 to 9.2 ± 8.6 (mean ± SD) with GD (p < 0.0001), facilitating detection and improved assessment of the primary tumour. In 25 (64 %) of the 39 patients with incidental suspicious gastric uptake, acquisition after GD correctly excluded a malignant process. In 10 (71 %) of the remaining 14 patients with persistent suspicious FDG uptake despite GD, malignancy was confirmed and in 3 (21 %) an active but benign pathology was diagnosed. GD is a simple way to improve local staging with FDG PET in patients with gastric malignancy. In the setting of incidental suspicious gastric

  14. FDG PET Imaging of Extremities in Rheumatoid Arthritis.

    Science.gov (United States)

    Dhawan, Richa; Lokitz, Kyla; Lokitz, Stephen; Caldito, Gloria; Takalkar, Amol M

    2016-01-01

    The primary objective of this study was to evaluate the utility of fluorodeoxyglucose positive emission tomography imaging in assessing the degree of joint inflammation and response to therapy in patients with rheumatoid arthritis using standard PET parameters. Five subjects with newly diagnosed RA were enrolled in this IRB-approved prospective study. After standard conventional workup that included clinical and laboratory evaluation and disease activity score (DAS3v) calculation, subjects underwent baseline FDG PET scans of their hands and feet prior to initiation of treatment and after six months of standard treatment. The uptake of FDG in involved joints was assessed qualitatively (visual evaluation) as well as semi quantitatively using standardized uptake value (SUV). Findings from the FDG PET scans were correlated with clinical and laboratory parameters including DAS and ESR. In all five patients, increased FDG uptake was noted in various joints affected by RA. The intensity of uptake varied from mild to intense (SUVmax values from 3.10 to 6.0). Overall, these correlated well with the clinical evaluation of involved joints. FDG PET imaging provided additional information by showing involvement in joints that were difficult to evaluate clinically (e.g. mid foot joints). The PET data also provided a distribution of joint involvement with varying degrees of severity in the same subject. On objective analysis using Spearman rank correlation coefficient for statistical analysis, no significant correlations were observed (p>0.05) between DAS, ESR, and the different PET parameters at baseline (before treatment) despite large calculated positive correlation coefficients. This was due to the small sample size (n=5). At post-treatment, the significant correlations were those between DAS and Maximum metabolic disease burden (MDB max) (RS=0.9, p=0.04) and between ESR and MDB max (RS=0.9, p=0.04). The positive correlations between total metabolic disease burden (Total MDB

  15. Emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Wengen; Bural, Gonca G.; Torigian, Drew A.; Alavi, Abass [Hospital of the University of Pennsylvania, Division of Nuclear Medicine, Department of Radiology, Philadelphia, PA (United States); Rader, Daniel J. [University of Pennsylvania, Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, School of Medicine, Philadelphia, PA (United States)

    2009-01-15

    Atherosclerosis is a dynamic inflammatory disorder. The biological composition and inflammatory state of an atherosclerotic plaque, rather than the degree of stenosis or its size are the major determinants of acute clinical events. A noninvasive technique to detect vulnerable atherosclerotic plaque is critically needed. FDG-PET/CT, a combined functional and structural whole-body imaging modality, holds great potential for this purpose. FDG uptake in large arteries has been frequently observed and is associated with cardiovascular risk factors. FDG accumulates in plaque macrophages and uptake is correlated with macrophage density. It is known that vascular FDG uptake and calcification do not overlap significantly and changes of FDG uptake are common, suggesting that FDG uptake may represent a dynamic inflammatory process. It has been reported that vascular FDG uptake can be attenuated by simvastatin in patients, and by the antiinflammatory drug probucol in rabbits. Vascular FDG uptake has been linked to cardiovascular events in some preliminary studies. Data from basic sciences, and animal and clinical studies support the emerging role of FDG-PET/CT in assessing atherosclerosis in large arteries in humans. (orig.)

  16. MRI and FDG PET/CT findings in 3 cases of spinal infectious arachnoiditis.

    Science.gov (United States)

    Dong, Aisheng; Zuo, Changjing; Zhang, Ping; Lu, Jianping; Bai, Yushu

    2014-10-01

    Spinal arachnoiditis is a disease characterized by inflammation and scarring of the arachnoid membrane of the spinal cord. FDG PET/CT findings of spinal arachnoiditis have been rarely reported. We present 3 cases of spinal infectious arachnoiditis (1 pyogenic and 2 tuberculous). MRI was performed in these 3 cases showing thickened spinal meninges with marked enhancement. FDG PET/CT was performed in 2 cases showing intense linear FDG uptake along the spinal canal. The combination of MRI and FDG PET/CT may be helpful in identifying the infectious sites and evaluating the activity of the infection.

  17. Clinical role of early dynamic FDG-PET/CT for the evaluation of renal cell carcinoma.

    Science.gov (United States)

    Nakajima, Reiko; Abe, Koichiro; Kondo, Tsunenori; Tanabe, Kazunari; Sakai, Shuji

    2016-06-01

    We studied the usefulness of early dynamic (ED) and whole-body (WB) FDG-PET/CT for the evaluation of renal cell carcinoma (RCC). One hundred patients with 107 tumours underwent kidney ED and WB FDG-PET/CT. We visually and semiquantitatively evaluated the FDG accumulation in RCCs in the ED and WB phases, and compared the accumulation values with regard to histological type (clear cell carcinoma [CCC] vs. non-clear cell carcinoma [N-CCC]), the TNM stage (high stage [3-4] vs. low stage [1-2]), the Fuhrman grade (high grade [3-4] vs. low grade [1-2]) and presence versus absence of venous (V) and lymphatic (Ly) invasion. In the ED phase, visual evaluation revealed no significant differences in FDG accumulation in terms of each item. However, the maximum standardized uptake value and tumour-to-normal tissue ratios were significantly higher in the CCCs compared to the N-CCCs (p evaluations. ED and WB FDG-PET/CT is a useful tool for the evaluation of RCCs. • ED and WB FDG-PET/ CT helps to assess patients with RCC • ED FDG-PET/CT enabled differentiation between CCC and N-CCC • FDG accumulation in the WB phase reflects tumour aggressiveness • Management of RCC is improved by ED and WB FDG-PET/CT.

  18. Decreased brain FDG uptake in patients with extensive non-Hodgkin's lymphoma lesions.

    Science.gov (United States)

    Hanaoka, Kohei; Hosono, Makoto; Shimono, Taro; Usami, Kimio; Komeya, Yoshihiro; Tsuchiya, Norio; Yamazoe, Yuzuru; Ishii, Kazunari; Tatsumi, Youichi; Sumita, Mitsugu

    2010-12-01

    Faint brain [(18)F]fluoro-2-deoxyglucose (FDG) uptake has sporadically been reported in patients with FDG-avid large or diffusely extended tumors. The purpose of this study was to investigate whether there is a correlation between massive tumor uptake and decreased brain uptake on FDG positron emission tomography/computed tomography (PET/CT). Sixty-five patients with histologically confirmed non-Hodgkin's lymphoma who underwent FDG-PET/CT were enrolled. Thirty control subjects were also included to evaluate normal brain FDG uptake. PET/CT examinations were retrospectively reviewed. The volumetric regions of interest were placed over lesions by referring to CT and PET/CT fusion images to measure mean standardized uptake value (SUVavg). The products of SUVavg and tumor volume were calculated as total glycolytic volume (TGV). The maximum SUV (SUVmax) and SUVavg were measured in the cerebrum and cerebellum. The values of TGV and brain FDG uptake were plotted and analyzed with a linear regression method. In the lymphoma patients, there were statistically significant negative correlations between TGV and brain SUVs. Demonstrating a significant negative correlation between TGV and brain uptake validated the phenomenon of decreased brain FDG uptake. Diversion of FDG from the brain to the lymphoma tissue may occur during the FDG accumulation process. Recognition of this phenomenon prevents unnecessary further neurological examinations in such cases.

  19. Suture Granuloma Showing False-Positive Findings on FDG-PET

    Directory of Open Access Journals (Sweden)

    Kohei Takahara

    2013-01-01

    Full Text Available We report a case of a 33-year-old male with a mixed germ-cell testicular tumor. Postoperative follow-up FDG-PET revealed concentration of FDG in the left inguinal area which is not tumor metastasis or local recurrence but suture reactivity granuloma. In this paper, we reviewed suture granulomas associated with false-positive findings on FDG-PET after surgery. If FDG-PET will be used more frequently in the future, it will be necessary to refrain from using silk thread in order to prevent any unnecessary surgery.

  20. Excretion of FDG into saliva and its significance for PET imaging

    Energy Technology Data Exchange (ETDEWEB)

    Stahl, A.; Dzewas, B.; Schwaiger, M.; Weber, W.A. [Dept. of Nuclear Medicine, Technische Univ. Muenchen (Germany)

    2002-10-01

    Aim: Assessment of the salivary excretion of FDG and its significance during PET imaging. Methods: Salivary samples from 16 patients were obtained during the first three hours after FDG injection and their activity concentrations were measured. Furthermore, regional FDG accumulations in whole body PET scans (60 min p.i., ROI technique) were determined in the following locations: vestibulum oris, floor of the mouth, hypopharynx, parotid gland, submandibular gland. This ROI analysis was repeated after drinking water (0.2 l) and a second scan (120 min p.i.). Results: The salivary FDG concentrations (SUV) at the first, second and third hour p.i. were 0.2 {+-} 0.1, 0.4 {+-} 0.2, and 0.3 {+-} 0.2, respectively. The FDG uptake in the investigated cranial and cervical sites ranged from SUV 1.2 {+-} 0.5 in the major salivary glands to 2.1 {+-} 0.5 in the floor of the mouth. These values remained unchanged after drinking of water. Conclusion: The salivary FDG concentration is higher than expected from the low physiologic content of glucose. This may - similarly to renal excretion - reflect a different behavior of FDG and glucose during reabsorption processes. Nevertheless, the salivary concentration of FDG is so low that no relevant influence on PET imaging is to be expected. Accordingly, the drinking of water prior to the scan is of no benefit for FDG PET imaging of the head and the neck. (orig.)

  1. Excretion of FDG into saliva and its significance for PET imaging.

    Science.gov (United States)

    Stahl, A; Dzewas, B; Schwaiger, M; Weber, W A

    2002-10-01

    Assessment of the salivary excretion of FDG and its significance during PET imaging. Salivary samples from 16 patients were obtained during the first three hours after FDG injection and their activity concentrations were measured. Furthermore, regional FDG accumulations in whole body PET scans (60 min p.i., ROI technique) were determined in the following locations: vestibulum oris, floor of the mouth, hypopharynx, parotid gland, submandibular gland. This ROI analysis was repeated after drinking water (0.2 l) and a second scan (120 min p.i.). The salivary FDG concentrations (SUV) at the first, second and third hour p.i. were 0.2 +/- 0.1, 0.4 +/- 0.2, and 0.3 +/- 0.2, respectively. The FDG uptake in the investigated cranial and cervical sites ranged from SUV 1.2 +/- 0.5 in the major salivary glands to 2.1 +/- 0.5 in the floor of the mouth. These values remained unchanged after drinking of water. The salivary FDG concentration is higher than expected from the low physiologic content of glucose. This may--similarly to renal excretion--reflect a different behavior of FDG and glucose during reabsorption processes. Nevertheless, the salivary concentration of FDG is so low that no relevant influence on PET imaging is to be expected. Accordingly, the drinking of water prior to the scan is of no benefit for FDG PET imaging of the head and the neck.

  2. Assesment of inflammatory response intensity in early postoperative period in patients after hernioplasty operated on with classic stoppa method and videoscopic TEP method.

    Science.gov (United States)

    Libiszewski, Michał; Drozda, Rafał; Białecki, Jacek; Wieloch, Maria; Hedayati, Masoud; Kuzdak, Krzysztof; Kołomecki, Krzysztof

    2011-09-01

    THE AIM OF THE STUDY was comparison of inflammatory response intensity through estimation of CRP, IL-6 and WBC concentration in blood serum in patients before and after inguinal hernia operations with Stoppa and TEP method. MATERIAL AND METHODS. The study involoved 117 patients operated on inguinal hernia between 2006-2008. The patients were divided into two groups. In the first group (group I - 56) Stopp'a method was used, in the second (group II - 61) TEP method. The patients selection was coincidental. All examined patients were men between 25-75 years old (mean age 54.3). Moreover, the operation's time, state of postoperative wound, the average hospitalization time and intensity of pain were estimated. The observations were directed over two weeks after operation. RESULTS. The inflammatory response estimated with CRP, IL-6 concentration in blood serum was considerably higher in patients operated with Stoppa method. There wasn't observed a relevant difference in increase of white blood cells' concentration in both groups. Moreover, the patients operated on with TEP method experienced lower pain. In group, operated on with Stoppa method, 3 cases of wound healing complications were observed. The operation's time was considerably shorter in the first group. The hospitalization time, was considerably shorter in patients operated on with videoscopic method. CONCLUSIONS. The operation of inguinal hernia with TEP technique in comparison with Stopp'a method is connected with considerably lower inflammatory response of organism, what directly involve with postoperative pain abridgment and reduction of hospitalization time. Moreover it may have influence on frequency of postoperative complications related with wound healing.

  3. Etude des Particules Exopolymériques Transparentes (TEP) en milieu marin. Dynamique et rôle dans le cycle du carbone

    OpenAIRE

    Beauvais, Sophie

    2003-01-01

    Devant le jury composé de: Paul Nival (Président du jury) France Van Wambeke (rapporteur) Robert Galois (rapporteur) Gerhard Herndl (examinateur) Fereidoun Rassoulzadegan (directeur de thèse) Maria-Luiza Pedrotti (codirecteur); The study of Transparent Exopolymeric Particles (TEP) has been a field of increasing interest over the past ten years. Their main source is exsudation of polysaccharides by phytoplankton and bacteria. These particles, which are formed abiotically, essentially by coagul...

  4. Magnetoresistance of Au films

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, D. L., E-mail: zhangdl@iphy.ac.cn; Song, X. H.; Zhang, X. [Institute of Physics, Chinese Academy of Sciences, Beijing 10081 (China); Zhang, X.-G., E-mail: xgz@ufl.edu [Department of Physics and Quantum Theory Project, University of Florida, Gainesville, Florida 32611 (United States); Center for Nanophase Materials Sciences and Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6493 (United States)

    2014-12-14

    Classical magnetoresistance (MR) in nonmagnetic metals are conventionally understood in terms of the Kohler rule, with violation usually viewed as anomalous electron transport, in particular, as evidence of non-Fermi liquid behavior. Measurement of the MR of Au films as a function of temperature and film thickness reveals a strong dependence on grain size distribution and clear violation of the Kohler rule. Using a model of random resistor network, we show that this result can be explained if the MR arises entirely from inhomogeneity due to grain boundary scattering and thermal activation of grain boundary atoms. Consequently, the Kohler rule should not be used to distinguish normal and anomalous electron transport in solids.

  5. Molecular cardiac PET besides FDG viability imaging; Molekulare Kardiale PET jenseits der FDG-Vitalitaetsdiagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Lindner, O.; Burchert, W. [Universitaetsklinik der Ruhr-Univ. Bochum (Germany). Inst. fuer Radiologie, Nuklearmedizin und Molekulare Bildgebung, Herz- und Diabetszentrum NRW

    2009-06-15

    Molecular cardiac non F-18-FDG PET is currently based on perfusion imaging. It is of excellent diagnostic accuracy to detect coronary artery disease (CAD) and superior to perfusion SPECT. There is also evidence for its incremental prognostic value. The unique feature of PET to measure myocardial perfusion in absolute terms and in short time periods define its impact on cardiac imaging enabling both the evaluation of early changes in CAD and the accurate characterization of multivessel disease. Currently, all available PET perfusion tracers in Europe are cyclotron products. Rb-82, a generator product, is the most frequently employed perfusion tracer in the United States and cyclotron independent. This tracer has the potential to become an alternative in Europe soon. Nowadays, PET systems are manufactured as hybrid PET-CT scanners. In oncology, hybrid imaging revealed, that the combination of functional and morphological imaging is superior to the single components. In cardiology, the integration of perfusion PET imaging with CT calcium scoring and CT anatomy of the coronary arteries represents a similar constellation. Atherosclerotic plaque evaluation by combined PET-CT technique will be one of the most promising future applications with a potential immense impact on prophylaxis, diagnosis and therapy of CAD in the future. (orig.)

  6. Quantitative real-time PCR analysis of Anopheles dirus TEP1 and NOS during Plasmodium berghei infection, using three reference genes

    Directory of Open Access Journals (Sweden)

    Jonathan W.K. Liew

    2017-07-01

    Full Text Available Quantitative reverse transcription PCR (qRT-PCR has been an integral part of characterizing the immunity of Anopheles mosquitoes towards Plasmodium invasion. Two anti-Plasmodium factors of Anopheles, thioester-containing protein 1 (TEP1 and nitric oxide synthase (NOS, play a role in the refractoriness of Anopheles towards Plasmodium infection and are generally expressed during infection. However, these are less studied in Anopheles dirus, a dominant malaria vector in Southeast Asia. Furthermore, most studies used a single reference gene for normalization during gene expression analysis without proper validation. This may lead to erroneous quantification of expression levels. Therefore, the present study characterized and investigated the expression profiles of TEP1 and NOS of Anopheles dirus during P. berghei infection. Prior to that, the elongation factor 1-alpha (EF1, actin 1 (Act and ribosomal protein S7 (S7 genes were validated for their suitability as a set of reference genes. TEP1 and NOS expressions in An. dirus were found to be significantly induced after P. berghei infection.

  7. Gene expression and 18FDG uptake in atherosclerotic carotid plaques

    DEFF Research Database (Denmark)

    Pedersen, Sune Folke; Græbe, Martin; Hag, Anne Mette Fisker

    2010-01-01

    by carotid endarterectomy. The gene expression of markers of vulnerability - CD68, IL-18, matrix metalloproteinase 9, cathepsin K, GLUT-1, and hexokinase type II (HK2) - were measured in plaques by quantitative PCR. RESULTS: In a multivariate linear regression model, GLUT-1, CD68, cathepsin K, and HK2 gene......) and an additional ipsilateral internal carotid artery stenosis of greater than 60% were recruited. FDG uptake in the carotids was determined by PET/computed tomography and expressed as mean and maximal standardized uptake values (SUVmean and SUVmax). The atherosclerotic plaques were subsequently recovered...... destabilization. Accordingly, FDG-PET could prove to be an important predictor of cerebrovascular events in patients with carotid plaques....

  8. Clinical, FDG and amyloid PET imaging in posterior cortical atrophy

    OpenAIRE

    Singh, Tarun D.; Josephs, Keith A.; Machulda, Mary M.; Drubach, Daniel A.; Apostolova, Liana G.; Lowe, Val J.; Whitwell, Jennifer L.

    2015-01-01

    The purpose of this study was to identify the clinical, [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and amyloid-PET findings in a large cohort of posterior cortical atrophy (PCA) patients, to examine the neural correlates of the classic features of PCA, and to better understand the features associated with early PCA. We prospectively recruited 25 patients who presented to the Mayo Clinic between March 2013 and August 2014 and met diagnostic criteria for PCA. All patients u...

  9. Clinical, FDG and amyloid PET imaging in posterior cortical atrophy.

    Science.gov (United States)

    Singh, Tarun D; Josephs, Keith A; Machulda, Mary M; Drubach, Daniel A; Apostolova, Liana G; Lowe, Val J; Whitwell, Jennifer L

    2015-06-01

    The purpose of this study was to identify the clinical, [(18)F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and amyloid-PET findings in a large cohort of posterior cortical atrophy (PCA) patients, to examine the neural correlates of the classic features of PCA, and to better understand the features associated with early PCA. We prospectively recruited 25 patients who presented to the Mayo Clinic between March 2013 and August 2014 and met diagnostic criteria for PCA. All patients underwent a standardized set of tests and amyloid imaging with [(11)C] Pittsburg compound B (PiB). Seventeen (68 %) underwent FDG-PET scanning. We divided the cohort at the median disease duration of 4 years in order to assess clinical and FDG-PET correlates of early PCA (n = 13). The most common clinical features were simultanagnosia (92 %), dysgraphia (68 %), poly-mini-myoclonus (64 %) and oculomotor apraxia (56.5 %). On FDG-PET, hypometabolism was observed bilaterally in the lateral and medial parietal and occipital lobes. Simultanagnosia was associated with hypometabolism in the right occipital lobe and posterior cingulum, optic ataxia with hypometabolism in left occipital lobe, and oculomotor apraxia with hypometabolism in the left parietal lobe and posterior cingulate gyrus. All 25 PCA patients were amyloid positive. Simultanagnosia was the only feature present in 85 % of early PCA patients. The syndrome of PCA is associated with posterior hemisphere hypometabolism and with amyloid deposition. Many of the classic features of PCA show associated focal, but not widespread, areas of involvement of these posterior hemispheric regions. Simultanagnosia appears to be the most common and hence sensitive feature of early PCA.

  10. FDG-SPECT and hibernation: an interim review; {sup 18}Fluor-FDG-SPECT zum Nachweis von hibernierendem Myokard: eine Zwischenbilanz

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, C. [Universitaetskliniken des Saarlandes, Homburg (Germany). Abt. fuer Nuklearmedizin; Schaefer, A. [Universitaetskliniken des Saarlandes, Homburg (Germany). Abt. fuer Nuklearmedizin; Trampert, L. [Universitaetskliniken des Saarlandes, Homburg (Germany). Abt. fuer Nuklearmedizin; Oberhausen, E. [Universitaetskliniken des Saarlandes, Homburg (Germany). Abt. fuer Nuklearmedizin; Kirsch, C.M. [Universitaetskliniken des Saarlandes, Homburg (Germany). Abt. fuer Nuklearmedizin; Berberich, R. [Universitaetskliniken des Saarlandes, Homburg (Germany). Abt. fuer Nuklearmedizin

    1997-06-01

    Aim: The present investigation demonstrates an intraindividual comparison of FDG-PET and FDG-SPECT. Material and Methods: Thirty patients with CHD and planed revascularisation underwent both modalities. Myocardial perfusion was evaluated by {sup 99m}Tc-MIBI SPECT. The myocardium was divided into 25 segments and the results were compared by two experienced observers. Results: Segmental concordance of FDG-PET and -SPECT was 94.1%. PET indicated a higher percentage of hibernating myocardium (8.9% vs. 5.7%) and a lower rate of matched defects (11.5% vs. 16.0%). In 22 cases the need for revascularisation was assessed identically. In the remaining 8 patients FDG-PET and FDG-SPECT required an intervention in 6 and 2 cases, respectively. Conclusion: The results of FDG-PET and FDG-SPECT showed a high segmental concordance, but the individual assessment of hibernation worthwhile for revascularisation demonstrated important differences in patient management. (orig.) [Deutsch] Ziel der vorliegenden Arbeit war ein intraindividueller Vergleich von FDG-PET und FDG-SPECT in der myokardialen Vitalitaetsdiagnostik. Material und Methodik: Bei 30 Patienten mit KHK wurden vor Revaskularisation beide Verfahren durchgefuehrt. Die Beurteilung der myokardialen Perfusion erfolgte mittels {sup 99m}Tc-MIBI SPECT. Die Resultate wurden von zwei erfahrenen Auswertern unter Verwendung einer 25-Segment-Einteilung des Myokards verglichen. Ergebnisse: Die segmentale Uebereinstimmung zwischen PET und SPECT betrug 94,1%. Die PET wies einen hoeheren Anteil hibernierendes Myokard aus (8,9% vs. 5,7%) und weniger Narbensegmente (11,5% bs. 16,0%). Die Indikation zur Revaskularisation wurde in 22 Faellen identisch beurteilt. Bei den uebrigen 8 Untersuchungen sprach sechsmal die PET und zweimal die SPECT fuer eine Intervention. Schlussfolgerung: Einer hohen segmentalen Uebereinstimmung stehen also erhebliche Unterschiede in der letztendlich entscheidenden klinischen Beurteilung der Untersuchungsergebnisse

  11. Results of imaging infection with [{sup 18}F]FDG and coincidence cameras; Ergebnisse der Entzuendungsdiagnostik mit [{sup 18}F]Fluor-Deoxyglukose (FDG) und Koinzidenz-Gammakameras

    Energy Technology Data Exchange (ETDEWEB)

    Meller, J.; Becker, W. [Goettingen Univ. (Germany). Abt. fuer Nuklearmedizin

    2001-11-01

    During the last years several reports about the role of FDG-PET in imaging inflammatory diseases either with dedicated systems or coincidence gamma cameras have been published. Based on these studies the value of FDG-imaging can now be determined for several entities. Most important data come from prospective studies which compared FDG-PET with established nuclear medicine procedures. Studies with coincidence cameras demonstrated that FDG may be the tracer of choice in the diagnostic work-up in patients with fever of unknown origin (FUO) and chronic bacterial osteomyelitis. The method also proved to be sensitive and specific in imaging infection outside the surgical wound in patients with postoperative fever, but the specificity of the method of detecting the focus of fever within the surgical wound was poor. It can be expected that FDG will be of further diagnostic value in other inflammatory diseases, especially in autoimmune disorders. (orig.) [German] Erst in den letzten Jahren wurden systematische klinische Arbeiten zum Einsatz von FDG, vorwiegend mit dedizierten PET-Systemen, aber auch mit Koinzidenz-Gammakameras bei entzuendlichen Erkrankungen publiziert, die es ermoeglichen, zu einzelnen Eintitaeten Aussagen ueber den Stellenwert der Methode machen zu koennen. Am aussagekraeftigsten sind hier vor allem Studien, die die FDG-PET mit etablierten nuklearmedizinischen Verfahren prospektiv verglichen haben. Bisherige Untersuchungen zeigen, dass eine Entzuendungsdiagnostik mittels Koinzidenz-Gammakamerasystemen und [{sup 18}F]FDG bei der Abklaerung von Fieber unklarer Genese (FUO) und der chronischen Osteomyelitis herkoemmlichen und bisher als Referenzmethoden angesehenen szintigraphischen Methoden ueberlegen ist. Bei postoperativen Fieberzustaenden kann die Methode aufgrund ihrer Unspezifitaet bei Verdacht auf eine Infektion im Operationsgebiet nicht empfohlen werden, waehrend sie ausserhalb des Operationsgebietes eine hohe diagnostische Genauigkeit aufweist. Es

  12. {sup 18}F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: {sup 18}F-FDG accumulates in foamy macrophages

    Energy Technology Data Exchange (ETDEWEB)

    Ishino, Seigo [Takeda Pharmaceutical Company Limited, Pharmaceutical Research Division, Fujisawa (Japan); Takeda Pharmaceutical Company Limited, Biomolecular Research Laboratories, Pharmaceutical Research Division, Fujisawa, Kanagawa (Japan); Ogawa, Mikako; Magata, Yasuhiro [Hamamatsu University School of Medicine, Medical Photonics Research Center, Hamamatsu (Japan); Mori, Ikuo; Nishimura, Satoshi; Ikeda, Shota; Sugita, Taku; Oikawa, Tatsuo; Horiguchi, Takashi [Takeda Pharmaceutical Company Limited, Pharmaceutical Research Division, Fujisawa (Japan)

    2014-04-15

    Intravascular ultrasonography (IVUS) and {sup 18}F-FDG PET have been used to evaluate the efficacy of antiatherosclerosis drugs. These two modalities image different characteristics of atherosclerotic plaques, and a comparison of IVUS and PET images with histology has not been performed. The aim of this study was to align IVUS and PET images using anatomic landmarks in Watanabe heritable hyperlipidaemic (WHHL) rabbits, enabling comparison of their depiction of aortic atherosclerosis. Cellular {sup 18}F-FDG localization was evaluated by {sup 3}H-FDG microautoradiography (micro-ARG). A total of 19 WHHL rabbits (7 months of age) were divided into three groups: baseline (n = 6), 3 months (n = 4), and 6 months (n = 9). PET, IVUS and histological images of the same aortic segments were analysed. Infiltration by foamy macrophages was scored from 0 to IV using haematoxylin and eosin (H and E) and antimacrophage immunohistochemical staining, and compared with {sup 3}H-FDG micro-ARG findings in two additional WHHL rabbits. IVUS images did not identify foamy macrophage deposition but revealed the area of intimal lesions (r = 0.87). {sup 18}F-FDG PET revealed foamy macrophage distribution in the plaques. The intensity of {sup 18}F-FDG uptake was correlated positively with the degree of foamy macrophage infiltration. Micro-ARG showed identical {sup 3}H-FDG accumulation in the foamy macrophages surrounding the lipid core of the plaques. F-FDG PET localized and quantified the degree of infiltration of foamy macrophages in atherosclerotic lesions. IVUS defined the size of lesions. {sup 18}F-FDG PET is a promising imaging technique for evaluating atherosclerosis and for monitoring changes in the composition of atherosclerotic plaques affecting their stability. (orig.)

  13. The effect of ultrapro or prolene mesh on postoperative pain and well-being following endoscopic Totally Extraperitoneal (TEP) hernia repair (TULP): study protocol for a randomized controlled trial.

    Science.gov (United States)

    Schouten, Nelleke; van Dalen, Thijs; Smakman, Niels; Elias, Sjoerd G; Clevers, Geert Jan; Verleisdonk, Egbert-Jan M M; Davids, Paul H P; Burgmans, Ine P J

    2012-06-07

    The purpose of this study was to describe the rationale and design of a randomized controlled trial analyzing the effects of mesh type (Ultrapro versus Prolene mesh) on postoperative pain and well-being following an endoscopic Totally Extraperitoneal (TEP) repair for inguinal hernias (short: TULP trial). The TULP trial is a prospective, two arm, double blind, randomized controlled trial to assess chronic postoperative pain and quality of life following implantation of a lightweight (Ultrapro) and heavyweight (Prolene) mesh in endoscopic TEP hernia repair. The setting is a high-volume single center hospital, specializing in TEP hernia repair. All patients are operated on by one of four surgeons. Adult male patients (≥18 years of age) with primary, reducible, unilateral inguinal hernias and no contraindications for TEP repair are eligible for inclusion in the study. The primary outcome is substantial chronic postoperative pain, defined as moderate to severe pain persisting ≥ 3 months postoperatively (Numerical Rating Scale, NRS 4-10). Secondary endpoints are the individual development of pain until three years after the TEP procedure, the quality of life (QoL), recurrence rate, patient satisfaction and complications. Large prospective randomized controlled studies with a long follow-up evaluating the incidence of chronic postoperative pain following implantation of lightweight and heavyweight mesh in endoscopic (TEP) hernia repair are limited. By studying the presence of pain and quality of life, but also complications and recurrences in a large patient population, a complete efficiency and feasibility assessment of both mesh types in TEP hernia repair will be performed. The TULP study is registered in the Dutch Trial Register (NTR2131).

  14. The effect of ultrapro or prolene mesh on postoperative pain and well-being following endoscopic Totally Extraperitoneal (TEP hernia repair (TULP: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Schouten Nelleke

    2012-06-01

    Full Text Available Abstract Background The purpose of this study was to describe the rationale and design of a randomized controlled trial analyzing the effects of mesh type (Ultrapro versus Prolene mesh on postoperative pain and well-being following an endoscopic Totally Extraperitoneal (TEP repair for inguinal hernias (short: TULP trial. Methods and design The TULP trial is a prospective, two arm, double blind, randomized controlled trial to assess chronic postoperative pain and quality of life following implantation of a lightweight (Ultrapro and heavyweight (Prolene mesh in endoscopic TEP hernia repair. The setting is a high-volume single center hospital, specializing in TEP hernia repair. All patients are operated on by one of four surgeons. Adult male patients (≥18 years of age with primary, reducible, unilateral inguinal hernias and no contraindications for TEP repair are eligible for inclusion in the study. The primary outcome is substantial chronic postoperative pain, defined as moderate to severe pain persisting ≥ 3 months postoperatively (Numerical Rating Scale, NRS 4–10. Secondary endpoints are the individual development of pain until three years after the TEP procedure, the quality of life (QoL, recurrence rate, patient satisfaction and complications. Discussion Large prospective randomized controlled studies with a long follow-up evaluating the incidence of chronic postoperative pain following implantation of lightweight and heavyweight mesh in endoscopic (TEP hernia repair are limited. By studying the presence of pain and quality of life, but also complications and recurrences in a large patient population, a complete efficiency and feasibility assessment of both mesh types in TEP hernia repair will be performed. Trial registration The TULP study is registered in the Dutch Trial Register (NTR2131

  15. Physiological {sup 18}F-FDG uptake in the ovaries and uterus of healthy female volunteers

    Energy Technology Data Exchange (ETDEWEB)

    Nishizawa, Sadahiko; Inubushi, Masayuki; Okada, Hiroyuki [Hamamatsu Medical Photonics Foundation, Hamamatsu Medical Imaging Center, Hamakita, Shizuoka (Japan)

    2005-04-01

    Good knowledge of physiological {sup 18}F-fluorodeoxglucose ({sup 18}F-FDG) uptake in the healthy population is of great importance for the correct interpretation of {sup 18}F-FDG positron emission tomography (PET) images of pathological processes. The purpose of this study was to investigate the physiological {sup 18}F-FDG uptake in the ovaries and uterus of healthy female volunteers. One hundred and 33 healthy females, 78 of whom were premenopausal (age 37.2{+-}6.9 years) and 55 postmenopausal (age 55.0{+-}2.7 years), were examined using whole-body {sup 18}F-FDG PET and pelvic magnetic resonance (MR) imaging. Focal {sup 18}F-FDG uptake in the ovaries and uterus was evaluated visually and using standardised uptake value (SUVs). Anatomical and morphological information was obtained from MR images. Distinct ovarian {sup 18}F-FDG uptake with an SUV of 3.9{+-}0.7 was observed in 26 premenopausal women out of 32 examined during the late follicular to early luteal phase of the menstrual cycle. Eighteen of the 32 women also showed focal {sup 18}F-FDG uptake in the endometrium, with an SUV of 3.3{+-}0.3. On the other hand, all nine women in the first 3 days of the menstrual cycle demonstrated intense {sup 18}F-FDG uptake in the endometrium, with an SUV of 4.6{+-}1.0. No physiological {sup 18}F-FDG uptake was observed in the ovaries or uterus of any postmenopausal women. In women of reproductive age, {sup 18}F-FDG imaging should preferably be done within a week before or a few days after the menstrual flow phase to avoid any misinterpretation of pelvic {sup 18}F-FDG PET images. (orig.)

  16. Optimizing {sup 18}F-FDG PET/CT imaging of vessel wall inflammation: the impact of {sup 18}F-FDG circulation time, injected dose, uptake parameters, and fasting blood glucose levels

    Energy Technology Data Exchange (ETDEWEB)

    Bucerius, Jan [Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, One Gustave L. Levy Place, P.O. Box 1234, New York, NY (United States); Mount Sinai School of Medicine, Department of Radiology, New York, NY (United States); Maastricht University Medical Center, Department of Nuclear Medicine, Maastricht (Netherlands); Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands); University Hospital, RWTH Aachen, Department of Nuclear Medicine, Aachen (Germany); Mani, Venkatesh; Fayad, Zahi A. [Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, One Gustave L. Levy Place, P.O. Box 1234, New York, NY (United States); Mount Sinai School of Medicine, Department of Radiology, New York, NY (United States); Mount Sinai School of Medicine, Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute and Marie-Josee and Henry R. Kravis Cardiovascular Health Center, New York, NY (United States); Moncrieff, Colin [Icahn School of Medicine at Mount Sinai, Translational and Molecular Imaging Institute, One Gustave L. Levy Place, P.O. Box 1234, New York, NY (United States); Mount Sinai School of Medicine, Department of Radiology, New York, NY (United States); Machac, Josef [Mount Sinai School of Medicine, Division of Nuclear Medicine, Department of Radiology, New York, NY (United States); Fuster, Valentin [Mount Sinai School of Medicine, Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute and Marie-Josee and Henry R. Kravis Cardiovascular Health Center, New York, NY (United States); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid (Spain); Farkouh, Michael E. [Mount Sinai School of Medicine, Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute and Marie-Josee and Henry R. Kravis Cardiovascular Health Center, New York, NY (United States); Mount Sinai School of Medicine, Cardiovascular Imaging Clinical Trials Unit, New York, NY (United States); Tawakol, Ahmed [Massachusetts General Hospital, Harvard University, Cardiac MR PET CT Program, Boston, MA (United States); Rudd, James H.F. [Cambridge University, Division of Cardiovascular Medicine, Cambridge (United Kingdom)

    2014-02-15

    {sup 18}F-FDG PET is increasingly used for imaging of vessel wall inflammation. However, limited data are available on the impact of methodological variables, i.e. prescan fasting glucose, FDG circulation time and injected FDG dose, and of different FDG uptake parameters, in vascular FDG PET imaging. Included in the study were 195 patients who underwent vascular FDG PET/CT of the aorta and the carotids. Arterial standardized uptake values ({sub mean}SUV{sub max}), target-to-background ratios ({sub mean}TBR{sub max}) and FDG blood-pool activity in the superior vena cava (SVC) and the jugular veins (JV) were quantified. Vascular FDG uptake values classified according to the tertiles of prescan fasting glucose levels, the FDG circulation time, and the injected FDG dose were compared using ANOVA. Multivariate regression analyses were performed to identify the potential impact of all variables described on the arterial and blood-pool FDG uptake. Tertile analyses revealed FDG circulation times of about 2.5 h and prescan glucose levels of less than 7.0 mmol/l, showing a favorable relationship between arterial and blood-pool FDG uptake. FDG circulation times showed negative associations with aortic{sub mean}SUV{sub max} values as well as SVC and JV FDG blood-pool activity, but positive correlations with aortic and carotid{sub mean}TBR{sub max} values. Prescan glucose levels were negatively associated with aortic and carotid{sub mean}TBR{sub max} and carotid{sub mean}SUV{sub max} values, but were positively correlated with SVC blood-pool uptake. The injected FDG dose failed to show any significant association with vascular FDG uptake. FDG circulation times and prescan blood glucose levels significantly affect FDG uptake in the aortic and carotid walls and may bias the results of image interpretation in patients undergoing vascular FDG PET/CT. The injected FDG dose was less critical. Therefore, circulation times of about 2.5 h and prescan glucose levels less than 7.0 mmol

  17. Deep venous thrombosis and pulmonary embolism detected by FDG PET/CT in a patient with bacteremia

    DEFF Research Database (Denmark)

    Nielsen, Anne Lerberg; Thomassen, Anders; Hess, Søren

    2013-01-01

    We report incidental FDG PET/CT findings of deep venous thrombosis and pulmonary embolism in a patient with bacteremia. In this patient, diagnosis of thromboembolism was not considered until FDG PET/CT imaging was performed, and the findings prompted immediate anticoagulant therapy. The role of FDG...

  18. 18F-FDG PET/CT prediction of malignant versus benign lesion in patients presenting with adnexal mass

    DEFF Research Database (Denmark)

    Frost, Majbritt; Iyer, Victor Vishwanath; Fisker, Rune Vincents

    2011-01-01

    indicated that 18F-FDG PET/CT description of malignant and benign was correct in 86 percent of patients. The correlation between the preoperative18F-FDG PET/CT-report, the intra-operative findings and the histopathological staging was satisfying. 18F-FDG PET/CT demonstrated areas of abnormally metabolic...

  19. Multifragmentation in Au + Au collisions studied with AMD-V

    Energy Technology Data Exchange (ETDEWEB)

    Ono, Akira [Tohoku Univ., Sendai (Japan). Faculty of Science

    1998-07-01

    AMD-V is an optimum model for calculation of multifragmentation in Au + Au collisions. AMD-V consider anti-symmetry of incident nucleus, target nucleus and fragments, furthermore, it treat the quantum effect to exist many channels in the intermediate and final state. 150 and 250 MeV/nucleon incident energy were used in the experiments. The data of multifragment atom in {sup 197}Au + {sup 197}Au collisions was reproduced by AMD-V calculation using Gognny force, corresponding to the imcompressibility of nuclear substance K = 228 MeV and its mean field depend on momentum. When other interaction (SKG 2 force, corresponding to K = 373 KeV) was used an mean field does not depend on momentum, the calculation results could not reproduce the experimental values, because nucleus and deuteron were estimated too large and {alpha}-particle and intermediate fragments estimated too small. (S.Y.)

  20. F 18 FDG PET/CT of a Gastric Schwannoma

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Il Ki; Kim, Deog Yoon [Kyung Hee Univ. School of Medicine, Seoul (Korea, Republic of)

    2011-09-15

    Schwannomas, also known as neurilemmomas, are tumors originating from nervous tissue; they have Schwann cell sheaths. According to a recent classification, about 80% of gastrointestinal mesenchymal tumors are gastrointestinal stromal tumors (GISTs). Gastrointestinal (GI) Schwannomas have been reported to represent only 3% of all GI mesenchymal tumors. These tumors make up only 0.2% of all gastric neoplasms. Schwannomas of the GI tract are distinctive from conventional Schwannomas that arise in soft tissue of the central nervous system. GI Schwannomas are hypothesized to arise from the myenteric plexus within the GI tract wall. These tumors are usually benign, slow growing and asymptomatic, and therefore most are discovered incidentally. The differentiation of Schwannomas from other submucosal tumors is very difficult. The main differential diagnosis for a mass arising in the wall of the gastointestinal tract is a GIST, which is a potentially malignant mesenchymal GI tumor that arises from the interstitial cells of Cajal, which help regulate peristalsis. The diagnostic determination of Schwannomas requires positive histological tests for S 100 protein and vimentin, but negative histological tests for smooth muscle actin and c KIT. In contrast, GISTs are C KIT positive and can be S 100 positive if they are located in small bowel. Because most patients with Schwannomas have excellent prognoses, surgical removal is sufficient for treatment. Gastric Schwannomas are normally benign, and malignant transformation is extremely rare. However, the current case illustrates that these tumors may exhibit avid F 18 FDG uptake. It remains unclear why high F 18 FDG uptake is found in benign tumors such as Schwannomas. F 18 FDG uptake in soft tissue and neural Schwannomas is variable but is frequently high, possibly due to over expression of the glucose transporter by tumor cells. In particular, glucose transporter type 3 is found in all human tissues and is the major glucose

  1. Potential Pitfall in the Assessment of Lung Cancer with FDG-PET/CT: Talc Pleurodesis Causes Intrathoracic Nodal FDG Avidity

    Directory of Open Access Journals (Sweden)

    Yingbing Wang

    2013-01-01

    Full Text Available Objective. Talc pleurodesis is a common procedure performed to treat complications related to lung cancer. The purpose of our study was to characterize any thoracic nodal findings on FDG PET/CT associated with prior talc pleurodesis. Materials and Methods. The electronic medical record identified 44 patients who underwent PET/CT between January 2006 and December 2010 and had a history of talc pleurodesis. For each exam, we evaluated the distribution pattern, size, and attenuation of intrathoracic lymph nodes and the associated standardized uptake value. Results. High-attenuation intrathoracic lymph nodes were noted in 11 patients (25%, and all had corresponding increased FDG uptake (range 2–9 mm. Involved nodal groups were anterior peridiaphragmatic (100%, paracardiac (45%, internal mammary (25%, and peri-IVC (18% nodal stations. Seven of the 11 patients (63% had involvement of multiple lymph nodal groups. Mean longitudinal PET/CT and standalone CT followups of 15±11 months showed persistence of both high-attenuation and increased uptake at these sites, without increase in nodal size suggesting metastatic disease involvement. Conclusions. FDG avid, high-attenuation lymph nodes along the lymphatic drainage pathway for parietal pleura are a relatively common finding following talc pleurodesis and should not be mistaken for nodal metastases during the evaluation of patients with history of lung cancer.

  2. Face au risque

    CERN Document Server

    Grosse, Christian; November, Valérie

    2007-01-01

    Ce volume collectif sur le risque inaugure la collection L'ÉQUINOXE. Ancré dans l'histoire pour mesurer les continuités et les ruptures, il illustre la manière dont les sciences humaines évaluent et mesurent les enjeux collectifs du risque sur les plans politiques, scientifiques, énergétiques, juridiques et éthiques. Puisse-t-il nourrir la réflexion sur la culture et la prévention du risque. Ses formes épidémiques, écologiques, sociales, terroristes et militaires nourrissent les peurs actuelles, structurent les projets sécuritaires et constituent - sans doute - les défis majeurs à notre modernité. Dans la foulée de la richesse scientifique d'Equinoxe, L'ÉQUINOXE hérite de son esprit en prenant à son tour le pari de contribuer - non sans risque - à enrichir en Suisse romande et ailleurs le champ éditorial des sciences humaines dont notre société a besoin pour forger ses repères. Après Face au risque suivra cet automne Du sens des Lumières. (MICHEL PORRET Professeur Ordinaire à la F...

  3. Is FDG-PET a useful tool in clinical practice for diagnosing corticobasal ganglionic degeneration?

    NARCIS (Netherlands)

    Coulier, IMF; de Vries, JJ; Leenders, KL

    2003-01-01

    Seven consecutive patients were suspected to suffer from corticobasal ganglionic degeneration (CBGD) and were studied with F-[18]-fluorodeoxyglucose (FDG) PET imaging of the brain. At the time of their FDG-PET scan, 4 of 7 patients fulfilled the clinical criteria of CBGD as proposed by Lang and

  4. Guidelines for 18F-FDG PET and PET-CT imaging in paediatric oncology

    DEFF Research Database (Denmark)

    Stauss, J.; Franzius, C.; Pfluger, T.

    2008-01-01

    tomography ((18)F-FDG PET) in paediatric oncology. The Oncology Committee of the European Association of Nuclear Medicine (EANM) has published excellent procedure guidelines on tumour imaging with (18)F-FDG PET (Bombardieri et al., Eur J Nucl Med Mol Imaging 30:BP115-24, 2003). These guidelines, published...

  5. A simple method for the quality control of [(18)F]FDG

    DEFF Research Database (Denmark)

    Koziorowski, J

    2010-01-01

    Most automated synthesis modules produce [(18)F]FDG within half an hour, but the quality control involving up to three separate methods and three different analytical systems is time consuming. The use of HPLC, TLC, and GC for the quality control of [(18)F]FDG is both time consuming and expensive...

  6. Efficacy of FDG PET/CT Imaging for Venous Thromboembolic Disorders

    DEFF Research Database (Denmark)

    Hess, Søren; Madsen, Poul Henning; Iversen, Else Dalsgaard

    2015-01-01

    PURPOSE: In recent years, several case reports have described venous thromboembolism (VTE) on FDG PET/CT. In this short communication, we present results from a proof-of-concept pilot study aimed at providing some preliminary data on the efficacy of FDG PET/CT in prospective patients with suspected...

  7. A Case of Asymptomatic Venous Air Embolism Demonstrated on 18F FDG PET/CT

    DEFF Research Database (Denmark)

    Dejanovic, Danijela; Alslev, Louise; Abrahamsson, Elisabeth

    2016-01-01

    We present the findings on F FDG PET/CT in connection with iatrogenic venous air embolism. The patient was referred for a posttreatment evaluation PET/CT for peripheral T-cell lymphoma. On the PET images, an intense FDG-uptake was seen in the injected vein. Simultaneous non-contrast-enhanced CT s...

  8. Dual-time FDG-PET/CT in patients with potential breast cancer recurrence

    DEFF Research Database (Denmark)

    Baun, Christina; Falch Braas, Kirsten; Gerke, Oke

    Dual-time FDG-PET/CT in patients with potential breast cancer recurrence: head-to-head comparison with CT and bonescintigraphy......Dual-time FDG-PET/CT in patients with potential breast cancer recurrence: head-to-head comparison with CT and bonescintigraphy...

  9. Clinical Application of {sup 18}F-FDG PET in Epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yu Kyeong [Seoul National University College of Medicine, Seoul National University Bundang Hospital, Sungnam (Korea, Republic of)

    2008-12-15

    FDG PET has been used as a diagnostic tool for localization of seizure focus for last 2-3 decades. In this article, the clinical usefulness of FDG PET in the management of patients with epilepsy has been reviewed, which provided the evidences to justify the medicare reimbursement for FDG PET in management of patients with epilepsy. Literature review demonstrated that FDG PET provides an important information in localization of seizure focus and determination whether a patients is a surgical candidate or not. FDG PET has been reported to have high diagnostic performance in localization of seizure focus in neocortical epilepsy as well as temporal lobe epilepsy regardless of the presence of structural lesion on MRI. Particularly, FDG PET can provide the additional information when the results from standard diagnositic modality such as interictal or video-monitored EEG, and MRI are inconclusive or discordant, and make to avoid invasive study. Furthermore, the presence of hypometabolism and extent of metabolic extent has been reported as an important predictor for seizure free outcome. However, studies suggested that more accurate localization and better surgical outcome could be expected with multimodal approach by combination of EEG, MRI, and functional studies using FDG PET or perfusion SPECT rather than using a single diagnostic modality in management of patients with epilepsy. Complementary use of FDG PET in management of epilepsy is worth for good surgical outcome in epilepsy patients.

  10. Cerebral metabolic changes (F-18-FDG PET) during selective anterior temporal lobe amobarbital test

    NARCIS (Netherlands)

    Khan, N; Hajek, M; Antonini, A; Maguire, P; Muller, S; Valavanis, A; Leenders, KL; Regard, M; Schiess, R; Wieser, HG

    1997-01-01

    Cerebral glucose utilisation using F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG PET) was measured in 4 patients with temporal lobe epilepsy during a selective anterior temporal lobe (TL) amobarbital test (ATLAT) and compared with their baseline values. F-18-FDG was injected

  11. (18)F-FDG PET/CT in a rare case of Stewart-Treves syndrome

    DEFF Research Database (Denmark)

    Jensen, Mads Radmer; Friberg, Lars; Karlsmark, Tonny

    2011-01-01

    BACKGROUND: The aim of this article is to illustrate the possible applications of (18)F-fluorodeoxyglucose positron emission tomography/computer tomography ((18)F-FDG PET/CT) in chronic extremity lymphedema and its complications. METHODS AND RESULTS: (18)F-FDG PET/CT findings in a rare case of St...

  12. The pivotal role of FDG-PET/CT in modern medicine

    DEFF Research Database (Denmark)

    Hess, Søren; Blomberg, Björn Alexander; Zhu, Hongyun June

    2014-01-01

    to the emergence of hybrid scanners combining PET with computed tomography (PET/CT). Molecular imaging has enormous potential for advancing biological research and patient care, and FDG-PET/CT is currently the most widely used technology in this domain. In this review, we discuss contemporary applications of FDG...

  13. Factors Associated with Diffusely Increased Splenic F-18 FDG Uptake in Patients with Cholangiocarcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Keunyoung; Kim, Seongjang; Kim, Injoo; Kim, Dong Uk; Kim, Heeyoung; Kim, Sojung; Ahn, Sang Hyun [Pusan National Univ. Hospital, Busan (Korea, Republic of)

    2014-06-15

    Although diffuse splenic {sup 18}F-fluorodeoxyglucose (F-18 FDG) uptake exceeding hepatic activity, is considered abnormal, its clinical significance is rarely discussed in the literature. The aim of this study was to determine the contributing factors causing diffusely increased splenic FDG uptake in patients with cholangiocarcinoma. From January 2010 to March 2013, 140 patients (84 men, 56 women) were enrolled in this study. All patients had been diagnosed with cholangiocarcinoma and underwent F-18 FDG positron emission tomography/computed tomography (PET/CT) for the pretreatment staging work up. Clinical records were reviewed retrospectively. Various hematological parameters, C-reactive protein (CRP) level, CEA, CA19-9, pancreatic enzymes and liver function tests were conducted within 2 days after the F-18 FDG PET/CT study. Diffuse splenic uptake was observed in 23 patients (16.4%). Of those, 19 patients (82.6%) underwent endoscopic retrograde cholangiopancreastography (ERCP) 7 days before F-18 FDG PET/CT. The CRP level (p <0.001) and white blood cell count (p =0.023) were significantly higher in the group of patients with diffuse splenic FDG uptake. The hemoglobin (p <0.001) and the hematocrit (p <0.001) were significantly lower in patients with diffuse splenic FDG uptake. Pancreatic enzymes, liver function test results, and tumor markers were not significantly different between the patients who did or did not have diffusely increased splenic FDG uptake. The significant factors for diffuse splenic F-18 FDG uptake exceeding hepatic F-18 FDG uptake on multivariate analysis included: performing ERCP before F-18 FDG PET-CT (odds ratio [OR], 77.510; 95% CI, 7.624-132.105), and the presence of leukocytosis (OR, 12.436; 95% CI, 2.438-63.445) or anemia (OR, 1.211; 95% CI, 1.051-1.871). In conclusion, our study demonstrated that concurrent inflammation could be associated with diffusely increased splenic FDG uptake. We suggest that performing ERCP before F-18 FDG PET

  14. Comparison of the open tension-free mesh-plug, transabdominal preperitoneal (TAPP), and totally extraperitoneal (TEP) laparoscopic techniques for primary unilateral inguinal hernia repair: a prospective randomized controlled trial.

    Science.gov (United States)

    Gong, Ke; Zhang, Nengwei; Lu, Yiping; Zhu, Bin; Zhang, Zhanzhi; Du, Dexiao; Zhao, Xia; Jiang, Haijun

    2011-01-01

    The open tension-free mesh-plug hernia technique, transabdominal preperitoneal (TAPP) technique, and totally extraperitoneal (TEP) laparoscopic technique all are common surgical procedures for primary unilateral inguinal hernia repair. However, the choice of the right surgical procedure still is controversial in China. This study aimed to compare open tension-free hernioplasty with two laparoscopic hernia repairs. In this study, 164 male patients with primary unilateral inguinal hernia were randomized to undergo an open operation with mesh-plug and patch, TAPP, or TEP. Completion of the study required 3 years, from February 2006 to February 2009. Of the 164 patients, 62 underwent open repair, 50 had TAPP, and 52 had TEP. The patients then were followed up for 15.6 ± 8.5 months. The average operating time for the open repair group was significantly shorter than for the other two groups (p TEP are safe and effective for patients with primary unilateral inguinal hernia. Both TAPP and TEP are superior to open repair in terms of less postoperative pain and faster recovery time. The authors therefore recommend laparoscopic repair techniques as the preferable choice of surgical procedure. However, they think open repair will remain a practical solution in China because of its lower cost, short learning period, and need for no special equipment.

  15. Giant cell tumor of the rib: Two cases of F-18 FDG PET/CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye Lim; Yoo, Le Ryung; Lee, Yeong Joo; Jung, Chan Kwon [Seoul St. Mary' s Hospital, College of MedicineThe Catholic University of Korea, Seoul (Korea, Republic of); Park, Sonya Young Ju [Molecular Imaging Program, Dept. of Radiology, Stanford Hospital and Clinics, Stanford (Korea, Republic of)

    2017-06-15

    We report two cases of giant cell tumor arising from the rib and their F-18 FDG PET/CT findings. The two patients complained of chest wall pain, and large lobulated soft tissue masses with intense FDG uptake were seen on F-18 FDG PET/CT. A malignant tumor such as osteosarcoma or chondrosarcoma was suspected due to the large size of the mass, bony destruction, and intense FDG uptake. En bloc resection was performed and final pathologic results revealed giant cell tumor of the rib. Giant cell tumor of the rib is very rare, and larger lesions with high FDG uptake can be misdiagnosed as an intrathoracic malignancy arising from the rib, pleura, or chest wall.

  16. HIV infection and arterial inflammation assessed by (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)

    DEFF Research Database (Denmark)

    Knudsen, Andreas; Hag, Anne Mette Fisker; Loft, Annika

    2015-01-01

    BACKGROUND: HIV-infected patients are at increased risk of myocardial infarction and arterial inflammation has been suggested as a pathophysiological explanation. We compared the uptake of 18F-fluorodeoxyglucose (FDG) by PET in four arterial regions, and factors associated with FDG uptake in well......-treated HIV-infected patients without cardiovascular disease (CVD) and healthy controls. METHODS AND RESULTS: We prospectively scanned 26 HIV-infected patients on stable antiretroviral therapy and 25 healthy volunteers with FDG PET/CT, measuring standardized uptake values (SUV) in the carotid arteries......, the ascending, descending, and abdominal aorta. We performed correlation analyses between FDG uptake and intima-media thickness (IMT), and soluble biomarkers of inflammation. We found no difference in arterial FDG uptake between the HIV-infected patients and healthy controls quantified either as mean SUVmax...

  17. Enhancement of the relative uptake of {sup 18}F-FDG in mouse fibrosarcoma by rolipram

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, Kaoru; Hosoi, Rie; Momosaki, Sotaro; Inoue, Osamu [Osaka Univ., Suita (Japan). School of Allied Health Science; Koike, Sachiko; Ando, Koichi [National Inst. of Radiological Sciences, Chiba (Japan); Nishimura, Tsunehiko [Kyoto Prefectural Univ. of Medicine (Japan)

    2002-11-01

    The effect of rolipram, a selective phosphodiesterase type 4 inhibitor, on the uptake of {sup 18}F-fluorodeoxyglucose ({sup 18}F-FDG) in tumor tissue was examined in mice transplanted with NFSa fibrosarcoma. The uptake indexes of {sup 18}F-FDG in the heart, skeletal muscle and brain remarkably decreased after treatment with 3 mg/kg of rolipram (heart: 13%, skeletal muscle: 14%, brain: 31%), but fibrosarcoma tissue showed only a 50% reduction in the uptake index of {sup 18}F-FDG. The tumor/muscle ratio of radioactivity 30 min after {sup 18}F-FDG injection was consequently enhanced from 1.9 to 6.5 by rolipram. This indicates the possible use of rolipram to enhance the sensitivity of tumor detection, as well as characterization of tumors in {sup 18}F-FDG PET. (author)

  18. Clinical value of FDG PET/CT in the diagnosis of suspected recurrent ovarian cancer: is there an impact of FDG PET/CT on patient management?

    Energy Technology Data Exchange (ETDEWEB)

    Bilici, Ahmet; Ustaalioglu, Bala Basak Oven; Seker, Mesut; Salepci, Taflan; Gumus, Mahmut [Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Medical Oncology, Istanbul (Turkey); Canpolat, Nesrin [Kosuyolu Yuksek Ihtisas Education and Research Hospital, Department of Nuclear Medicine, Istanbul (Turkey); Tekinsoy, Bulent [Medipol Hospital, Department of Radiology, Istanbul (Turkey)

    2010-07-15

    The aim of this study was to evaluate the clinical value of FDG PET/CT in patients with suspected ovarian cancer recurrence as compared with diagnostic CT, and to assess the impact of the results of FDG PET/CT on treatment planning. Included in this retrospective study were 60 patients with suspected recurrent ovarian cancer who had previously undergone primary debulking surgery and had been treated with adjuvant chemotherapy. Diagnostic CT and FDG PET/CT imaging were performed for all patients as clinically indicated. The changes in the clinical management of patients according to the results of FDG PET/CT were also analysed. FDG PET/CT was performed in 21 patients with a previously negative or indeterminate diagnostic CT scan, but an elevated CA-125 level, and provided a sensitivity of 95% in the detection of recurrent disease. FDG PET/CT revealed recurrent disease in 19 patients. In 17 of 60 patients, the indication for FDG PET/CT was an elevated CA-125 level and an abnormal diagnostic CT scan to localize accurately the extent of disease. FDG PET/CT scans correctly identified recurrent disease in 16 of the 17 patients, a sensitivity of 94.1%. Moreover, FDG PET/CT was performed in 18 patients with clinical symptoms of ovarian cancer recurrence, an abnormal diagnostic CT scan, but a normal CA-125 level. In this setting, FDG PET/CT correctly confirmed recurrent disease in seven patients providing a sensitivity of 100% in determining recurrence. In four patients, FDG PET/CT was carried out for the assessment of treatment response. Three of four scans were classified as true-negative indicating a complete response. In the other patient, FDG PET/CT identified progression of disease. In total, 45 (75%) of the 60 patients had recurrent disease, in 14 (31.1%) documented by histopathology and in 31 (68.9%) on clinical follow-up, while 15 (25%) had no evidence of recurrent disease. The overall sensitivity, specificity, accuracy, and positive and negative predictive value

  19. Chiral magnetic effect search in p+Au, d+Au and Au+Au collisions at RHIC

    Science.gov (United States)

    Zhao, Jie; STAR Collaboration

    2017-09-01

    The chiral magnetic effect (CME) is a fundamental property of QCD. A major background source for CME measurements is the intrinsic particle correlations (such as resonances/jets decay) coupled with the azimuthal elliptical anisotropy v2. In heavy-ion collisions, the magnetic field direction and event plane azimuthal angle Ψ2 are correlated, thus the CME and the v2-induced background are entangled. In small system p+Au and d+Au collisions, the Ψ2 is mostly due to geometry fluctuations, and thus magnetic field direction and Ψ2 are uncorrelated. The correlation measurements in small system collisions with respect to Ψ2 are only sensitive to v2-induced background while any CME is averaged to zero. In this talk, we will present the STAR measurements of two-particle correlations with respect to Ψ2 in p+Au, d+Au and Au+Au collisions at √{sNN} = 200 GeV. These results are analyzed as a function of particle multiplicity to shed light on the background contaminations of the CME measurements in heavy-ion collisions. We will also report results from a new analysis approach as a function of the particle pair invariant mass in order to suppress non-CME related physics backgrounds.

  20. Clinical Significance of 18F-FDG-PET in Invasive Lobular Carcinoma.

    Science.gov (United States)

    Fujii, Takaaki; Yajima, Reina; Kurozumi, Sasagu; Higuchi, Toru; Obayashi, Sayaka; Tokiniwa, Hideaki; Nagaoka, Rin; Takata, Daisuke; Horiguchi, Jun; Kuwano, Hiroyuki

    2016-10-01

    The diagnostic utility of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) for breast cancer is controversial. The histological type or tumor size of breast cancer has been reported to be associated with a greater likelihood of positive FDG uptake. Compared to invasive ductal carcinomas (IDCs), invasive lobular carcinomas (ILCs) have a lower level of FDG uptake and are detected at a significantly lower sensitivity. The role of preoperative FDG-PET for ILCs may, thus, be limited. Few data evaluating the significance of FDG-PET in ILCs are available. Here, we evaluated the clinical significance of FDG-PET for ILC patients. We retrospectively investigated the cases of 196 consecutive patients with primary breast cancer who were diagnosed as having ILC (n=15) or IDC (n=181) and underwent FDG-PET preoperatively. Fifteen (7.7%) of patients were histopathologically diagnosed as ILC. A univariate analysis revealed that tumor size, extent of tumor, estrogen receptor (ER) expression and progesterone receptor (PgR) expression were significantly different between the ILC and IDC groups. The maximum standardized uptake value (SUVmax) values of the primary tumors were not significantly different between the two groups but, regardless of the larger size of tumor or ductal spread, the SUVmax was relatively lower in the ILC group compared to the IDC group. The tumors in two ILC cases showed no FDG uptake. Among the ILC cases, there were linear associations between SUVmax and tumor size and between SUVmax and the nuclear grade by Pearson correlation (r=0.447, p=0.048 and r=0.519, p=0.024, respectively). Our findings imply that the preoperative FDG uptake in ILC may be reflective of the tumor size and the nuclear grade of the tumor. FDG uptake may be useful and predictive of aggressive features or prognosis in ILC patients. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  1. FDG scan on an ordinary coincidence gamma camera (CDET) -preliminary data in pulmonary or colorectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Montravers, F.; Grahek, D.; Ghazzar, N.; Younsi, N.; Kerrou, K.; Talbot, J.N. [Hopital Tenon, 75 - Paris (France). Services de Medecine Nucleaire; Wartski, M.; Zerbib, E. [Hopital Marie Lannelongue Le Plessis Robinson (France); Lumbroso, J. [Institut Gustave Roussy Villejuif (France)

    1997-12-31

    Full text. The purpose of this study to evaluate the impact of FDG scan performed on an ordinary CDET gamma camera on the therapeutic management of patients with pulmonary nodules or with suspicion of recurrent colorectal carcinoma. Methods: two tomoscintigrams (thorax and abdomen) were acquired, using a PICKER Prism XP 2000 coincidence gamma camera, 45 m after i.v. injection of 100-150 MBq of {sup 18} F-FDG in fasting patients. The 21 pts were explored in July or August 1997. Preliminary results: among 12 patients with pulmonary nodules, the planed surgery was replaced by chemotherapy after visualization of unknown metastases accumulating FDG in 3 patients. In another one, the high uptake of FDG by a lung nodule which has been known for 6 years, led to surgery and objectivation of an adenocarcinoma. In one case, the absence of FDG uptake corresponded to an abscess (true negative result). In the other 7 patients, the indication of surgery was confirmed but the procedure was modified in 2 cases. In case of suspicion of recurrent colorectal carcinoma (9 patients), the finding of a single focus of FDG uptake whereas CT scan was negative or inconclusive let do the decision of surgery in 3 patients. In one patient with pelvic pain without increase of tumor markers levels and with normal CT scan, a normal FDG scan confirmed the physician`s hypothesis of pain due to the previous therapy but do not recurrence. In one patient, the finding of 3 foci of uptake of FDG whereas CT scan was inconclusive confirmed the indication of chemotherapy. In 2 patients with FDG abdominal foci without morphologic abnormalities, the therapeutic strategy is not yet decided in 2 patients, no foci could be found. In conclusion, these preliminary results show that FDG scan has provided a help to the physician indecision-making for therapeutic strategy in 8 patients on 21 (38%) and a help to the surgeon in 2 more cases (48% as a whole)

  2. Fat necrosis after abdominal surgery: A pitfall in interpretation of FDG-PET/CT.

    Science.gov (United States)

    Davidson, Tima; Lotan, Eyal; Klang, Eyal; Nissan, Johnatan; Goldstein, Jeffrey; Goshen, Elinor; Ben-Haim, Simona; Apter, Sara; Chikman, Bar

    2017-12-20

    We describe FDG-PET/CT findings of postoperative fat necrosis in patients following abdominal surgery, and evaluate their changes in size and FDG uptake over time. FDG-PET/CT scans from January 2007-January 2016 containing the term 'fat necrosis' were reviewed. Lesions meeting radiological criteria of fat necrosis in patients with prior abdominal surgery were included. Forty-four patients, 30 males, mean age 68.4 ± 11.0 years. Surgeries: laparotomy (n=37; 84.1 %), laparoscopy (n=3; 6.8 %), unknown (n=4; 9.1 %). CTs of all lesions included hyperdense well-defined rims surrounding a heterogeneous fatty core. Sites: peritoneum (n=34; 77 %), omental fat (n=19; 43 %), subcutaneous fat (n=8; 18 %), retroperitoneum (n=2; 5 %). Mean lesion long axis: 33.6±24.9 mm (range: 13.0-140.0). Mean SUVmax: 2.6±1.1 (range: 0.6-5.1). On serial CTs (n=34), lesions decreased in size (p=0.022). Serial FDG-PET/CT (n=24) showed no significant change in FDG-avidity (p=0.110). Mean SUVmax did not correlate with time from surgery (p=0.558) or lesion size (p=0.259). Postsurgical fat necrosis demonstrated characteristic CT features and may demonstrate increased FDG uptake. However, follow-up of subsequent imaging scans showed no increases in size or FDG-avidity. Awareness of this entity is important to avoid misinterpretation of findings as recurrent cancer. • Postsurgical fat necrosis may mimic cancer in FDG-PET/CT. • Follow-up of fat necrosis showed no increase in FDG intensity. • CT follow-up showed a decrease in lesion size. • FDG uptake did not correlate with time lapsed from surgery.

  3. Characteristic of {sup 18}F-FDG Excretion According to Use Diuretics in {sup 18}F-FDG of PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Dong Gun; Yang, Seoung Oh; Lee, Sang Ho [Dept. of Nuclear Medicine, Dongnam Institute of Radiological and Medical Sciences Cancer Center, Busan (Korea, Republic of); Bae, Jong Lim [Dept. of Physics, Daegu University, Daegu (Korea, Republic of); Kim, Jeong Koo [Dept. of Radiological Science, Hanseo University, Seosan (Korea, Republic of)

    2012-06-15

    {sup 18}F-fluorodeoxyglucose ({sup 18}F-FDG) causes a significant amount of radioactivity retention in kidneys and urinary tract and degrades image quality and diagnostic performance. Diuretics are used to perform tests and prevent the urinary tract retention of {sup 18}F-FDG. The purpose of the study is to investigate how the diuretics affect images and excretion rates of {sup 18}F-FDG. The study consists of a group using diuretics for patients with no primary tumors or transfer lesions in kidneys according to PET/CT images, a group using physiological saline and the control group injecting only {sup 18}F-FDG and SUVs are measured by configuring interested areas for each group. Also, SUVs are compared and evaluated depending on the lasix injection after basic inspection and injecting {sup 18}F-FDG for quantitative analysis. The study shows that images with decreased background radioactivity and increased urine excretion due to using diuretics. However, an opposite result that there is no change in the amount of radioactivity in urine appears. The study concludes that the diuretics may decrease background radioactivity in the images but may not affect the {sup 18}F-FDG excretion.

  4. Metabolic fate of 18F-FDG in mice bearing either SCCVII squamous cell carcinoma or C3H mammary carcinoma

    DEFF Research Database (Denmark)

    Kaarstad, Katrin; Bender, Dirk; Bentzen, Lise

    2002-01-01

    Tumors often have an increased uptake of glucose and can be detected by PET imaging using 18F-FDG. 18F-FDG is converted to 18F-FDG-6-phosphate (18F-FDG-6-P), and the usual assumption is that 18F-FDG-6-P is not a substrate for subsequent enzymatic reactions and that tumor hot spots reflect trapping...

  5. {sup 18F} FDG PET/CT Findings in a Breast Cancer Patient with Concomitant Tuberculous Axillary Lymphadenitis

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Won [Jeju National Univ. Hospital, Jeju (Korea, Republic of); Lee, Sang Mi [Soonchunhyang Univ. Cheonan Hospital, Cheonan (Korea, Republic of); Choi, Jae Hyuck [Jeju National Univ. School of Medicine, Jeju (Korea, Republic of)

    2011-06-15

    Although {sup 18F} fluorodeoxyglucose ({sup 18F} FDG) positron emission tomography (PET) is a sensitive modality for detecting a malignant lesion, increased {sup 18F} FDG uptake is also seen in infected or inflammatory processes. Here, we report the case of a a breast cancer patient with concomitant tuberculous axillary lymphadenitis that showed increased {sup 18F} FDG uptake. A 39 year old woman underwent preoperative {sup 18F} FDG PET/computed tomography (CT) as a part of the work up for right breast cancer. {sup 18F} FDG PET/CT images showed a malignant lesion in the right breast with moderate {sup 18F} FDG uptake, and multiple enlarged right axillary lymph nodes with intense {sup 18F} FDG uptake. Subsequently, the patient underwent right mastectomy and right axillary lymph node dissection. Histopathological examination confirmed breast cancer and tuberculous lymphadenitis, and the patient was treated concomitantly with anti tuberculous therapy.

  6. Interest of the PET with fluorodeoxyglucose labelled with fluorine 18 in an unexplained feverish dorsalgia; Interet de la TEP au fluorodeoxyglucose marque au fluor 18 dans une dorsalgie febrile inexpliquee

    Energy Technology Data Exchange (ETDEWEB)

    Cristofol, H.; Esquerre, J.P.; Payoux, P. [Medecine nucleaire, CHU Purpan, Toulouse, (France); Delavigne, K. [medecine interne, CHU Purpan, Toulouse, (France)

    2009-05-15

    The objective of tis work is to show that the PET with {sup 18}F-F.D.G. allows to do a diagnosis in the fevers of undetermined origin, where other examination turns out to be negative. In the studied case, it was an active Horton disease. The cortico-therapy could be begin as the PET allowed also to rule out the possibility of an infectious centre. This example questions about the place of skeleton scintigraphy and scanner in the management of fevers of undetermined origin compared to the PET. (N.C.)

  7. Patterns of pulmonary tuberculosis on FDG-PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Soussan, Michael, E-mail: michael.soussan@avc.aphp.fr [Université Paris 13, Faculté de médecine SMBH, Department of Nuclear Medicine, CHU Avicenne, 125 rue de Stalingrad, 93000 Bobigny (France); Brillet, Pierre-Yves [Université Paris 13, Faculté de médecine SMBH, Department of Radiology, CHU Avicenne, 125 rue de Stalingrad, 93000 Bobigny (France); Mekinian, Arsène [Université Paris 13, Faculté de médecine SMBH, Department of Internal Medicine, Hôpital Jean Verdier, Bondy (France); Khafagy, Abrahim [Université Paris 13, Faculté de médecine SMBH, Department of Radiology, CHU Avicenne, 125 rue de Stalingrad, 93000 Bobigny (France); Nicolas, Patrick [Université Paris 13, Faculté de médecine SMBH, Department of Pharmacology, CHU Avicenne, 125 rue de Stalingrad, 93000 Bobigny (France); Vessieres, Annie [Université Paris 13, Faculté de médecine SMBH, Department of Bacteriology, CHU Avicenne, 125 rue de Stalingrad, 93000 Bobigny (France); Brauner, Michel [Université Paris 13, Faculté de médecine SMBH, Department of Radiology, CHU Avicenne, 125 rue de Stalingrad, 93000 Bobigny (France)

    2012-10-15

    Objective: This study aims to describe patterns of pulmonary tuberculosis (TB) on FDG-PET/CT. Methods: All patients with a diagnosis of TB and who underwent FDG-PET/CT between January 2009 and June 2010 were included. Clinical, biological and imaging data were reviewed. TB was proven either on bacteriological or histopathological studies (n = 13) or on a clinical and imaging basis (n = 3). Results: Sixteen patients (11 men; median age 56, range 22–84 years) were included. Two distinct patterns were identified. In the lung pattern (9/16), patients had predominantly pulmonary symptoms (6/9 patients, 67%) with a parenchymal involvement: uptakes on lung consolidation ± cavitation surrounded by micronodules. Mediastino-hilar lymph nodes were slightly enlarged (15 mm, 10–27) with moderate uptake (3.9, 2.5–13.4). In the lymphatic pattern (7/16), patients had predominantly systemic symptoms (5/7 cases, 71%) and all had extra-thoracic involvement. Mediastino-hilar lymph nodes were more enlarged (30 mm, 18–35, p = 0.03) and with higher uptake (6.8, 5.7–16.8, p = 0.034) than in the lung pattern. Conclusion: We identified two distinct patterns of pulmonary TB on FDG-PET/CT. The lung pattern related to a restricted and slight hypermetabolic infection and the lymphatic pattern related to a systemic and intense infection. Combined interpretation of PET and CT findings improves the specificity of images, especially for the lung pattern.

  8. Dual time point 18FDG-PET/CT versus single time point 18FDG-PET/CT for the differential diagnosis of pulmonary nodules - A meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Li; Wang, Yinzhong [The First Clinical Medical School of Lanzhou Univ., Lanzhou, Gansu (China); Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou Univ., Lanzhou, Gansu (China); Lei, Junqiang; Tian, Jinhui; Zhai, Yanan [The First Clinical Medical School of Lanzhou Univ., Lanzhou, Gansu (China); Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou Univ., Lanzhou, Gansu (China); The First Hospital of Lanzhou Univ., Lanzhou, Gansu (China)

    2013-09-15

    Background: Lung cancer is one of the most common cancer types in the world. An accurate diagnosis of lung cancer is crucial for early treatment and management. Purpose: To perform a comprehensive meta-analysis to evaluate the diagnostic performance of dual time point 18F-fluorodexyglucose position emission tomography/computed tomography (FDG-PET/CT) and single time point 18FDG-PET/CT in the diagnosis of pulmonary nodules. Material and Methods: PubMed (1966-2011.11), EMBASE (1974-2011.11), Web of Science (1972-2011.11), Cochrane Library (-2011.11), and four Chinese databases; CBM (1978-2011.11), CNKI (1994-2011.11), VIP (1989-2011.11), and Wanfang Database (1994-2011.11) were searched. Summary sensitivity, summary specificity, summary diagnostic odds ratios (DOR), and summary positive likelihood ratios (LR+) and negative likelihood ratios (LR-) were obtained using Meta-Disc software. Summary receiver-operating characteristic (SROC) curves were used to evaluate the diagnostic performance of dual time point 18FDG-PET/CT and single time point 18FDG-PET/CT. Results: The inclusion criteria were fulfilled by eight articles, with a total of 415 patients and 430 pulmonary nodules. Compared with the gold standard (pathology or clinical follow-up), the summary sensitivity of dual time point 18FDG-PET/CT was 79% (95%CI, 74.0 - 84.0%), and its summary specificity was 73% (95%CI, 65.0-79.0%); the summary LR+ was 2.61 (95%CI, 1.96-3.47), and the summary LR- was 0.29 (95%CI, 0.21 - 0.41); the summary DOR was 10.25 (95%CI, 5.79 - 18.14), and the area under the SROC curve (AUC) was 0.8244. The summary sensitivity for single time point 18FDG-PET/CT was 77% (95%CI, 71.9 - 82.3%), and its summary specificity was 59% (95%CI, 50.6 - 66.2%); the summary LR+ was 1.97 (95%CI, 1.32 - 2.93), and the summary LR- was 0.37 (95%CI, 0.29 - 0.49); the summary DOR was 6.39 (95%CI, 3.39 - 12.05), and the AUC was 0.8220. Conclusion: The results indicate that dual time point 18FDG-PET/CT and single

  9. Borophene synthesis on Au(111)

    Science.gov (United States)

    Guisinger, Nathan; Kiraly, Brian; Zhang, Zhuhua; Mannix, Andrew; Hersam, Mark C.; Yakobson, Boris I.

    The recent experimental discovery of borophene, the metallic 2-dimensional allotrope of boron, has sparked tremendous interest in further exploration of this unique material. The initial synthesis of borophene was accomplished on Ag substrates and serves as a quintessential example of predictive modeling to experimental realization. In this talk, we expand the phase-space of borophene synthesis to Au. Borophene synthesis was accomplished by evaporating elemental boron onto a Au(111) substrate. The synthesized borophene retains its metallic character on Au as verified with scanning tunneling spectroscopy. Most fascinating is the difference in growth dynamics on the Au(111) substrate where the reconstructed surface presents a unique energy landscape for borophene nucleation and growth. We find that the initial low-coverage growth of borophene modifies the herringbone reconstruction into a ``trigonal'' network, where the 2D boron islands are uniformly templated across the surface. Increasing coverage results in the increasing size of the templated borophene islands until they coalesce into larger sheets. The observed growth dynamics are supported by the computational modeling of boron nucleation on Au.

  10. L’apprentissage au cern

    CERN Multimedia

    2007-01-01

    pour les professions d’électronicien(ne) et de laborantin(e) en physique L’apprentissage au CERN est régi par les lois, règlements et contrats en vigueur dans le canton de Genève. En cas de réussite à l’examen de fin d’apprentissage, les apprentis obtiennent le Certificat fédéral de capacité suisse (CFC). 6 places au total sont ouvertes au recrutement pour les deux professions. L’apprentissage dure 4 ans. Minima requis pour faire acte de candidature : avoir au moins 15 ans et moins de 21 ans à la date de début de l’apprentissage ; avoir terminé la scolarité obligatoire, au minimum 9e du Cycle d’orientation genevois (3e en France) ; être ressortissant d’un pays membre du CERN (Allemagne, Autriche, Belgique, Bulgarie, Danemark, Espagne, Finlande, France, Grèce, Hongrie, Italie, Norvège, Pays-Bas, Pologne, Portugal, Royaume-Uni, République tchèque, République slovaque , Suède, Suisse) ; pour les résidents en Suisse : être ressortissant su...

  11. Transverse Velocity Scaling in Au+Au Fragmentation

    OpenAIRE

    Lukasik, J.; Hudan, S.; Lavaud, F.; Turzo, K.; Auger, G.; Bacri, Ch.O.; Begemann-Blaich, M.L.; Bellaize, N.; Bittiger, R.; Bocage, F.; Borderie, B.; Buchet, P.; R. Bougault(LPCC); Bouriquet, B.; Charvet, J. L.

    2002-01-01

    Invariant transverse-velocity spectra of intermediate-mass fragments were measured with the 4-pi multi-detector system INDRA for collisions of Au on Au at incident energies between 40 and 150 MeV per nucleon. Their scaling properties as a function of incident energy and atomic number Z are used to distinguish and characterize the emissions in (i) peripheral collisions at the projectile and target rapidities, and in (ii) central and (iii) peripheral collisions near mid-rapidity. The importance...

  12. Controversies on the prognostic value of interim FDG-PET in advanced-stage Hodgkin lymphoma.

    Science.gov (United States)

    Adams, Hugo J A; Kwee, Thomas C

    2016-12-01

    Hodgkin lymphoma, even in advanced-stage, is a highly curable malignancy, but treatment is associated with short-term toxicity and long-term side effects. Early predictive markers are required to identify those patients who do not require the full-length standard therapy (and thus qualify for therapy de-escalation) and those patients who will not be cured by standard therapy (and thus qualify for therapy escalation). Multiple trials have assessed the value of (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) after a few cycles of chemotherapy (also known as 'interim FDG-PET') in predicting outcome in advanced-stage Hodgkin lymphoma. Furthermore, multiple interim FDG-PET-adapted trials, in which patients with positive interim FDG-PET scans are assigned to escalated therapies, and patients with negative interim FDG-PET scans are assigned to de-escalated therapies, have recently been published or are currently ongoing, with generally heterogeneous results. The present article reports the currently available evidence (and controversies) on the prognostic value of interim FDG-PET in advanced-stage Hodgkin lymphoma in patients with positive and negative interim FDG-PET findings following continuation of standard chemotherapy or escalated/de-escalated therapy. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  13. Dynamic observation of 18F-FDG uptake after oral administration in a healthy subject.

    Science.gov (United States)

    Zhang, Kaixiu; Wang, Xuemei; Hao, Linjun; Zhao, Zhenfeng; Han, Chunlei

    2013-06-01

    PET with (18)F-FDG is a widely used imaging modality in cancer patients. Traditionally, (18)F-FDG is administrated intravenously. However, patients with difficult venous access are not rare in clinical practice. The purpose of the current study was to investigate the dynamic process of (18)F-FDG distribution after oral administration in order to determine the optimal imaging acquisition time in human subjects. On the basis of tissue time-activity curves, we determined the time that was required to reach 90% of the maximal uptake in target organs. In a 50-y-old healthy subject with oral (18)F-FDG administration, we found that (18)F-FDG uptake maximized at 60 min for most organs except for the gray matter of the brain, which continued to accumulate (18)F-FDG after 60 min. Time to 90% was 22 min for liver, 36 min for kidneys, 48 min for myocardium, 50 min for bladder, 56 min for sigmoid colon, and greater than 61 min for gray matter of the brain. We suggest that PET images be acquired at around 60 min after oral (18)F-FDG administration for most organs. For the brain, a longer interval is required before acquisition.

  14. Lymphadenopathy resulting from acute hepatitis C infection mimicking metastatic breast carcinoma on FDG PET/CT.

    Science.gov (United States)

    Jacene, Heather A; Stearns, Vered; Wahl, Richard L

    2006-07-01

    We report a case documenting fluorodeoxyglucose (FDG) accumulation in upper abdominal lymph nodes resulting from acute hepatitis C infection. A 42-year-old African-American female with a history of metastatic breast carcinoma was found to have hypermetabolic porta hepatic, peripancreatic, and paraaortic lymphadenopathy and hypermetabolism in the spleen on a surveillance FDG positron emission tomography/computed tomography (PET/CT) scan. Concurrently, she was diagnosed with acute hepatitis C infection. Antiviral therapy was not recommended secondary to the low level of detectable virus at the time of diagnosis. Her breast cancer therapy regimen was continued unaltered. FDG PET/CT scan was repeated 2 months later as a result of concern that the hypermetabolic lymph nodes represented metastatic disease; however, the scan revealed complete resolution of the previously abnormal findings. The resolution of the lymphadenopathy and the patient's clinical course led to the conclusion that the most likely explanation for the FDG PET/CT findings was inflammation secondary to acute hepatitis C infection and not metastatic breast carcinoma. Inflammatory and infectious processes accumulate FDG, occasionally resulting in false-positives for malignancy. Infected macrophages in the lymph nodes draining the liver in this case and stimulation of a cellular immune response by the hepatitis C virus, with resultant cytokine production by cytotoxic and T-helper cells, offer possible explanations for the findings seen on FDG PET/CT in this case. This case highlights the importance of clinical history and laboratory correlation for the proper interpretation of FDG PET scans.

  15. FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC.

    Science.gov (United States)

    van Gool, Matthijs H; Aukema, Tjeerd S; Hartemink, Koen J; Valdés Olmos, Renato A; van Tinteren, Harm; Klomp, Houke M

    2014-07-28

    Over recent years, [18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography (FDG-PET/CT) has proven its role as a staging modality in patients with non-small cell lung cancer (NSCLC). The purpose of this review was to present the evidence to use FDG-PET/CT for response evaluation in patients with NSCLC, treated with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI). All published articles from 1 November 2003 to 1 November 2013 reporting on 18F-FDG-PET response evaluation during EGFR-TKI treatment in patients with NSCLC were collected. In total 7 studies, including data of 210 patients were eligible for analyses. Our report shows that FDG-PET/CT response during EGFR-TKI therapy has potential in targeted treatment for NSCLC. FDG-PET/CT response is associated with clinical and radiologic response and with survival. Furthermore FDG-PET/CT response monitoring can be performed as early as 1-2 wk after initiation of EGFR-TKI treatment. Patients with substantial decrease of metabolic activity during EGFR-TKI treatment will probably benefit from continued treatment. If metabolic response does not occur within the first weeks of EGFR-TKI treatment, patients may be spared (further) unnecessary toxicity of ineffective treatment. Refining FDG-PET response criteria may help the clinician to decide on continuation or discontinuation of targeted treatment.

  16. The Potential Roles of 18F-FDG-PET in Management of Acute Stroke Patients

    Directory of Open Access Journals (Sweden)

    Adomas Bunevicius

    2013-01-01

    Full Text Available Extensive efforts have recently been devoted to developing noninvasive imaging tools capable of delineating brain tissue viability (penumbra during acute ischemic stroke. These efforts could have profound clinical implications for identifying patients who may benefit from tPA beyond the currently approved therapeutic time window and/or patients undergoing neuroendovascular treatments. To date, the DWI/PWI MRI and perfusion CT have received the most attention for identifying ischemic penumbra. However, their routine use in clinical settings remains limited. Preclinical and clinical PET studies with [18F]-fluoro-2-deoxy-D-glucose (18F-FDG have consistently revealed a decreased 18F-FDG uptake in regions of presumed ischemic core. More importantly, an elevated 18F-FDG uptake in the peri-ischemic regions has been reported, potentially reflecting viable tissues. To this end, this paper provides a comprehensive review of the literature on the utilization of 14C-2-DG and 18F-FDG-PET in experimental as well as human stroke studies. Possible cellular mechanisms and physiological underpinnings attributed to the reported temporal and spatial uptake patterns of 18F-FDG are addressed. Given the wide availability of 18F-FDG in routine clinical settings, 18F-FDG PET may serve as an alternative, non-invasive tool to MRI and CT for the management of acute stroke patients.

  17. Focal Colonic FDG Activity with PET/CT: Guidelines for Recommendation of Colonoscopy.

    Science.gov (United States)

    Liu, Tianye; Behr, Spencer; Khan, Sana; Osterhoff, Robert; Aparici, Carina Mari

    2015-01-01

    Focal (18)F-fluorodeoxyglucose (FDG) colonic activity can be incidentally seen in positron emission tomography/computed tomography (PET/CT) scans. Its clinical significance is still unclear. The purpose of this study was to assess the significance of focal FDG activity in PET/CT scans by correlating the imaging findings to colonoscopy results, and come up with some guidelines for recommendation of follow-up colonoscopy. A total of 133 patients who underwent both (18)F-FDG PET/CT for different oncological indications and colonoscopy within 3 months were retrospectively studied. Imaging, colonoscopy and pathology results were analyzed. Of the 133 FDG-PET/CT scans, 109/133 (82%) did not show focal colonic FDG activity, and 24/133 (18%) did. Of the 109/133 PET/CTs without focal colonic FDG activity, 109/109 (100%) did not have evidence of colon cancer after colonoscopy and histology. Of the 24/133 PET/CTs with focal colonic FDG activity, 10/24 (42%) had pathologic confirmation of colon cancer and 14/24 (58%) did not have evidence of colon cancer after colonoscopy and histological analysis. Sensitivity was 10/10 (100%), specificity 109/123 (89%), positive predictive value (PPV) 10/24 (42%) and negative predictive value (NPV) 109/109 (100%). Incidental focal (18)FDG activity in PET/CT imaging shows a high sensitivity, specificity and NPV for malignancy, with a not so high PPV of 42%. Although some people would argue that a 42% chance of malignancy justifies colonoscopy, this maybe is not possible in all cases. However, the high sensitivity of the test does not allow these studies to be overlooked. We provide our recommendations as per when to send patients with focal FDG colonic activity to have further characterization with colonoscopy.

  18. The impact of FDG-PET on the management algorithm for recurrent colorectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Arulampalam, T.; Boulos, P.; Taylor, I. [Dept. of Surgery, Royal Free and University College Medical School, London (United Kingdom); Costa, D.; Visvikis, D.; Ell, P. [Inst. of Nuclear Medicine, Royal Free and University College Medical School, London (United Kingdom)

    2001-12-01

    Positron emission tomography (PET) has been successfully used to image colorectal cancer (CRC). This study evaluated the accuracy of 2-[{sup 18}F]-fluoro-2-deoxy-D-glucose (FDG) PET for the detection and staging of recurrent CRC and the consequent impact on clinical management. Forty-two patients previously treated for CRC were investigated for suspected recurrence and, if recurrence was confirmed, the extent of disease was evaluated. All patients underwent whole-body FDG-PET and computed tomography (CT) scan and results were compared to assess sensitivity, specificity and diagnostic accuracy for each modality. We then assessed the FDG-PET directed alteration in clinical management from that planned on the basis of spiral CT results. FDG-PET was more sensitive (93%) than CT (73%) for detection of recurrence (specificity 58% and 75%, respectively). FDG-PET yielded a correct diagnosis in 35 (83%) out of 42 patients, while CT did so in 31 patients (74%). FDG-PET was more accurate than CT for staging local recurrence (sensitivity 100%, specificity 86% with FDG-PET vs 75% and 100%, respectively, with CT) and CRC liver metastases (sensitivity 100% vs 45%; specificity 100% for both). Overall, PET upstaged 8 out of 30 patients (27%) and altered patient management in 16 (38%) cases. This study confirms that FDG-PET is more sensitive than CT for the detection and staging of recurrent CRC. The results also indicate that FDG-PET is an accurate means of selecting appropriate patients for operative treatment. When applied to routine clinical practice, patient management is altered. (orig.)

  19. Community-Based Global Health Program for Maltreated Children and Adolescents in Brazil: The Equilibrium Program (TEP

    Directory of Open Access Journals (Sweden)

    Andrea Horvath Marques

    2015-07-01

    Full Text Available The maltreatment of children and adolescents is a global public health problem that affects high and low-middle income countries (LMICs. In the United States, around 1.2 million children suffer from abuse, while in LMICs such as Brazil these rates are much higher (an estimated 28 million children. Exposition to early environmental stress has been associated with suboptimal physical and brain development, persistent cognitive impairment and behavioral problems. Studies have reported that children exposed to maltreatment are at high risk of behavioral problems, learning disabilities, communication and psychiatric disorders and general clinical conditions such as obesity and systemic inflammation later in life. The aim of this paper is to describe The Equilibrium Program (TEP, a community-based global health program implemented in São Paulo, Brazil to serve traumatized and neglected children and adolescents. We will describe and discuss TEP’s implementation, highlighting its innovation aspects, research projects developed within the program as well as its population profile. Finally, we will discuss TEP’s social impact, challenges and limitations. The program’s goal is to promote the social and family reintegration of maltreated children and adolescents through an interdisciplinary intervention program that provides multi-dimensional bio-psycho-social treatment integrated with the diverse services needed to meet the unique demands of this population. The program’s cost-effectiveness is being evaluated to support the development of more effective treatments and to expand similar programs in other areas of Brazil. Policy makers should encourage early evidence-based interventions for disadvantaged children to promote healthier psychosocial environments and provide them opportunities to become healthy and productive adults. This approach has already shown itself to be a cost-effective strategy to prevent disease and promote health.

  20. Food residue granuloma mimicking metastatic disease on FDG-PET/CT.

    Science.gov (United States)

    Crucitti, Antonio; Grossi, Ugo; Leccisotti, Lucia; Maggi, Fabio; Ricci, Riccardo; Mazzari, Andrea; Tomaiuolo, Pasquina M C; Giordano, Alessandro

    2013-05-01

    A 31-year-old woman presenting with acute abdomen underwent an emergency Hartmann's procedure for fecal peritonitis due to perforated adenocarcinoma of the left colon. Shortly after a 7-month course of adjuvant chemotherapy, follow-up contrast-enhanced CT showed multiple peritoneal and hepatic nodules, showing focal intense and homogeneous FDG uptake on FDG-PET/CT, highly suspected for recurrence of disease. Excisional biopsy of the nodules revealed foreign body granulomas made up of alimentary materials surrounded by a fibrous wall. We report a unique case of a false-positive finding secondary to food residues mimicking metastatic disease on FDG-PET in a patient with colon cancer.

  1. Carcinoma en Cuirasse from Recurrent Breast Cancer seen on FDG-PET/CT.

    Science.gov (United States)

    Win, Aung Zaw; Aparici, Carina Mari

    2015-01-01

    Our patient was a 36-year-old female diagnosed with Grade II ER+/PR-/Her-2 - ductal carcinoma in situ (DCIS) in the left breast. She underwent left lumpectomy and received treatment with tamoxifen and radiotherapy. Three years later, she presented with multiple diffused skin nodules on the chest and upper left arm. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) exam showed widespread metastasis in the chest, upper left arm, left axillary lymph nodes, and left suprascapular muscle. FDG-PET/CT imaging of breast carcinoma en cuirasse is very rare. FDG-PET/CT is useful in detecting recurrent breast cancer.

  2. Characterizing bone marrow involvement in Hodgkin's lymphoma by FDG-PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Weiler-Sagie, Michal; Kagna, Olga [Rambam Health Care Campus, Nuclear Medicine Department, Haifa (Israel); Dann, Eldad J. [Rambam Health Care Campus and B. and R. Rappaport Faculty of Medicine, Technion, Hematology Department, Haifa (Israel); Ben-Barak, Ayelet [Rambam Health Care Campus and B. and R. Rappaport Faculty of Medicine, Technion, Pediatric Hemato-Oncology Department, Haifa (Israel); Israel, Ora [Rambam Health Care Campus and B. and R. Rappaport Faculty of Medicine, Technion, Nuclear Medicine Department, Haifa (Israel)

    2014-06-15

    Fluoro-deoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) is superior to iliac bone marrow biopsy (iBMB) for detection of bone marrow involvement (BMI) in staging of Hodgkin's lymphoma (HL). The present study aims to characterize the patterns and distribution of BMI in HL as determined by FDG-PET/CT. Reports of FDG-PET/CT studies performed for staging of HL were reviewed. BMI was defined as positive iBMB and/or foci of pathological FDG uptake in the skeleton that behaved in concordance with other sites of lymphoma in studies following chemotherapy. Number of FDG uptake foci, their specific location in the skeleton and the presence of corresponding lesions in the CT component of the study, and stage according to the Ann Arbor staging system, were recorded. The study included 473 patients. iBMB was performed in 336 patients. Nine patients had positive iBMB (9/336, 3 %). Seventy-three patients (73/473, 15 %) had FDG-PET/CT-defined BMI. The BM was the only extranodal site of HL in 52/473 patients (11 %). Forty-five patients had three or more foci of pathological skeletal FDG uptake (45/73, 62 %). Sixty-four patients (64/73, 88 %) had at least one uptake focus in the pelvis or vertebrae. In 60 patients (60/73, 82 %), the number of skeletal FDG uptake foci without corresponding CT lesions was equal to or higher than the number of foci with morphological abnormalities. FDG-PET/CT demonstrated BMI in 15 % of patients with newly diagnosed HL. Diagnosis of BMI in HL by FDG-PET/CT was more sensitive than iBMB with potential upstage in 11 % of patients. The most common pattern of FDG-PET/CT BMI was multifocal (at least three foci) skeletal FDG uptake, with at least one focus in the pelvis or vertebrae and no corresponding CT lesions. (orig.)

  3. When to image carotid plaque inflammation with FDG PET/CT

    DEFF Research Database (Denmark)

    Græbe, Martin; Borgwardt, Lise; Højgaard, Liselotte

    2010-01-01

    Quantification of 18-fluorodeoxyglucose (FDG) uptake in inflamed high-risk carotid atherosclerotic plaques is challenged by the spatial resolution of positron emission tomography (PET) and luminal blood activity. Late acquisition protocols have been used to overcome these challenges to enhance...... the contrast between the plaque and blood-pool FDG activity. However, for prospective studies the late acquisition is inconvenient for the patient and staff, and most retrospective studies of plaque uptake use data from early acquisition protocols. The objective was to evaluate changes in the quantification...... methods of FDG uptake in carotid artery plaques between early and late PET scans....

  4. F-18 FDG PET in the initial evaluation of high risk melanoma

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, T.; Zerdoud, S.; Faurie, C.; Chevreau, C.; Courbon, F. [Institut Claudius Regaud, 31 - Toulouse (France)

    2008-02-15

    Introduction. - Localized melanoma is a potentially aggressive tumor. Its prognosis depends mainly on pathologic factors, namely: thickness (Breslow index), presence of ulceration and microscopic nodal metastasis. FDG PET is the modality of choice for evaluation of advanced melanoma and has proven its superiority in terms of sensitivity, specificity and accuracy compared to conventional imaging. Early stages of melanoma do not seem to benefit from PET FDG. However the value of PET FDG in staging localized high risk melanoma is yet to be determined. Patients and methods. - We have evaluated 87 patients with high risk melanoma with PET FDG. 32 patients presented with a Breslow index superior or equal to 4 mm, 21 with a Breslow index inferior to 4 mm and ulceration and 34 with a positive sentinel lymphadenectomy. PET FDG was realized after at least 6 h of fasting on a hybrid PET-CT G.E. Discovery S.T. scan for 65 of them. The rest of the patients were evaluated on a Siemens Ecat H.R. + scan. Scans were interpreted by an experimented nuclear medicine physician and were classified as positive or negative. All equivocal scans or cases for which there was discordance between the scan result and follow up were reviewed by 2 experimented nuclear medicine physicians and a consensus was reached. Results. - FDG PET was positive in seven patients, four scans were true positive and identified regional metastatic disease. No distant metastatic visceral disease was found. The three false positive scans consisted of a cyst adeno-lymphoma in one case, mediastinal and axillary uptake in the other two cases and no sign of evolution more than six months after the scan. Four patients with a negative scan showed metastatic disease in the six months following the PET scan. FDG PET had an impact on therapeutic management on two patients (2%). When evaluating FDG PET for regional disease with sentinel node biopsy as a reference, we found values of sensitivity, specificity, predictive

  5. FDG-PET/CT findings in systemic mastocytosis: a French multicentre study

    Energy Technology Data Exchange (ETDEWEB)

    Djelbani-Ahmed, S. [Assistance Publique - Hopitaux de Paris (APHP), Department of Nuclear Medicine, Avicenne Hospital, Bobigny (France); Paris 13 University, Sorbonne Paris Cite, Bobigny (France); Chandesris, M.O. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (France); Necker Children' s Hospital, APHP, Department of Haematology, Paris (France); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (France); Mekinian, A.; Fain, O. [Saint Antoine Hospital, Department of Internal Medicine and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), AP-HP, Paris (France); Canioni, D. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (France); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (France); Necker Children' s Hospital, APHP, Department of Pathology, Paris (France); Brouzes, C. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (France); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (France); Necker Children' s Hospital, APHP, Laboratory of Haematology, Paris (France); Hanssens, K. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (France); Aix-Marseille University, INSERM U1068, Centre de Recherche en Cancerologie de Marseille (Signaling, Hematopoiesis and Mechanism of Oncogenesis), Paoli Calmettes Institute, Marseille (France); Pop, G.; Eder, V. [Assistance Publique - Hopitaux de Paris (APHP), Department of Nuclear Medicine, Avicenne Hospital, Bobigny (France); Durieu, I.; Durupt, S. [Universite de Lyon, Department of Internal and Vascular Medicine, Hospices Civils de Lyon, Groupe Hopitalier Sud, Pierre-Benite (France); Grosbois, B.; Besnard, S. [Rennes University Hospital, Department of Internal Medicine, Rennes (France); Tournilhac, O. [Clermont-Ferrand University Hospital, Department of Internal Medicine, Clermont-Ferrand (France); Beyne-Rauzy, O. [Purpan University Hospital, Department of Internal Medicine, Toulouse (France); Agape, P. [Saint-Denis University Hospital, Department of Oncology and Haematology, Saint-Denis de la Reunion (France); Delmer, A. [Reims University Hospital, Department of Haematology, Reims (France); Ranta, D. [Brabois University Hospital, Department of Haematology, Vandoeuvre les Nancy (France); Jeandel, P.Y. [Nice University Hospital, Department of Internal Medicine, Nice (France); Georgin-Lavialle, S. [Tenon Hospital, Department of Internal Medicine, Paris (France); Frenzel, L.; Hermine, O. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (FR); Necker Children' s Hospital, APHP, Department of Haematology, Paris (FR); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (FR); Damaj, G. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (FR); Caen University Hospital, Department of Haematology, Caen (FR); Lortholary, O. [Necker Children' s Hospital, APHP, French Reference center for Mastocytosis (Centre de Reference des Mastocytoses, CEREMAST), Paris (FR); Paris Descartes University, Sorbonne Paris Cite, Imagine Institute, Paris (FR); Pasteur Institute, Department of Infectious Diseases and Tropical Medicine, Necker Children' s Hospital, APHP, Paris (FR); Soussan, M. [Assistance Publique - Hopitaux de Paris (APHP), Department of Nuclear Medicine, Avicenne Hospital, Bobigny (FR); Paris 13 University, Sorbonne Paris Cite, Bobigny (FR)

    2015-12-15

    Mastocytosis is a clonal haematological disease characterized by uncontrolled proliferation and the activation of mast cells. The value of FDG-PET/CT (FDG-PET) in mastocytosis has yet to be determined. We retrospectively identified patients with an established diagnosis of systemic mastocytosis (SM), according to the WHO criteria, who underwent PET using the French Reference Centre for Mastocytosis database. Semi-quantitative and visual analysis of FDG-PET was performed and compared to the clinico-biological data. Our cohort included 19 adult patients, median age 65 years [range 58-74], including three with smouldering SM (SSM), three with aggressive SM (ASM), 10 with an associated clonal haematological non-mast-cell lineage disease (SM-AHNMD), and three with mast cell sarcoma (MCS). FDG-PET was performed at the time of the SM diagnosis (15/19), to evaluate lymph node (LN) activity (3/19) or the efficacy of therapy (1/19). FDG uptake was observed in the bone marrow (BM) (9/19, 47 %), LN (6/19, 32 %), spleen (12/19, 63 %), or liver (1/19, 5 %). No significant FDG uptake was observed in the SSM and ASM patients. A pathological FDG uptake was observed in the BM of 6/10 patients with SM-AHNMD, appearing as diffuse and homogeneous, and in the LN of 5/10 patients. All 3 MCS patients showed intense and multifocal BM pathological uptake, mimicking metastasis. No correlation was found between the FDG-PET findings and serum tryptase levels, BM mast cell infiltration percentage, and CD30 and CD2 expression by mast cells. FDG uptake does not appear to be a sensitive marker of mast cell activation or proliferation because no significant FDG uptake was observed in most common forms of mastocytosis (notably purely aggressive SM). However, pathological FDG uptake was observed in the SM-AHNMD and in MCS cases, suggesting a role of FDG-PET in their early identification and as a tool of therapeutic assessment in this subgroup of patients. (orig.)

  6. Disseminated tuberculosis in a patient with AIDS on F-18 FDG PET/CT

    Directory of Open Access Journals (Sweden)

    Yunfang Li

    2015-12-01

    Full Text Available Disseminated tuberculosis due to opportunistic infections is important to be diagnosed as early as possible because of the high lethality involved with AIDS. A 28-year-old patient with AIDS was hospitalized for intermittent lumbago. A fluorine-18 fluorodeoxyglucose (F-18 FDG positron emission tomography (PET/computed tomography (CT scan showed varying degrees of FDG uptakes in the multiple lesions of the whole body. We presented a case of disseminated tuberculosis in a patient with acquired immunodeficiency syndrome (AIDS and discussed the usefulness of F-18 FDG PET/CT in the diagnosis of the disseminated tuberculosis.

  7. The role of FDG-PET in Hodgkin lymphoma

    Science.gov (United States)

    Hałka, Janusz; Dziuk, Mirosław

    2017-01-01

    18-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is currently the most valuable imaging technique in Hodgkin lymphoma. Since its first use in lymphomas in the 1990s, it has become the gold standard in the staging and end-of-treatment remission assessment in patients with Hodgkin lymphoma. The possibility of using early (interim) PET during first-line therapy to evaluate chemosensitivity and thus personalize treatment at this stage holds great promise, and much attention is now being directed toward this goal. With high probability, it is believed that in the near future, the result of interim PET-CT would serve as a compass to optimize treatment. Also the role of PET in pre-transplant assessment is currently evolving. Much controversy surrounds the possibility of detecting relapse after completed treatment with the use of PET in surveillance in the absence of symptoms suggestive of recurrence and the results of published studies are rather discouraging because of low positive predictive value. This review presents current knowledge about the role of 18-FDG-PET/CT imaging at each point of management of patients with Hodgkin lymphoma. PMID:28947879

  8. Role of FDG PET/CT in Baastrup's disease.

    Science.gov (United States)

    Subramanyam, Padma; Palaniswamy, Shanmuga Sundaram

    2016-01-01

    Baastrup's disease is a benign condition, which presents as chronic low back pain. It is also known as "kissing spine syndrome" and refers to close approximation of adjacent spinous processes producing inflammation and back pain. This condition is often misdiagnosed, resulting in incorrect treatment and persistence of symptoms. Diagnosis of Baastrup's disease is verified with clinical examination and imaging studies. Conventionally, clinicians resort to magnetic resonance imaging (MRI) of spine rather than X-ray or computed tomography (CT) in the evaluation of back pain. MRI can additionally identify flattening, sclerosis, enlargement, cystic lesions, and bone edema at the articulating surfaces of the two affected spinous processes. Studies have reported that (18)Fluorine fluorodeoxyglucose-positron emission tomography/CT (FDG-PET/CT) can detect a bursitis or an inflammation as a form of stress reaction despite a negative MRI and (99m)Tc Methylene diphosphonate (MDP) bone scan. PET/CT is usually not a recommended investigation for this condition. However, this case report highlights the benefit of FDG-PET/CT in identifying the site of inflammatory pathology. It is also known to identify the exact site of inflammation where steroid or local anesthetic injection can be administered to alleviate pain, especially in patients with multilevel vertebral involvement.

  9. Multiscale Modeling of Au-Island Ripening on Au(100

    Directory of Open Access Journals (Sweden)

    Karin Kleiner

    2011-01-01

    Full Text Available We describe a multiscale modeling hierarchy for the particular case of Au-island ripening on Au(100. Starting at the microscopic scale, density functional theory was used to investigate a limited number of self-diffusion processes on perfect and imperfect Au(100 surfaces. The obtained structural and energetic information served as basis for optimizing a reactive forcefield (here ReaxFF, which afterwards was used to address the mesoscopic scale. Reactive force field simulations were performed to investigate more diffusion possibilities at a lower computational cost but with similar accuracy. Finally, we reached the macroscale by means of kinetic Monte Carlo (kMC simulations. The reaction rates for the reaction process database used in the kMC simulations were generated using the reactive force field. Using this strategy, we simulated nucleation, aggregation, and fluctuation processes for monoatomic high islands on Au(100 and modeled their equilibrium shape structures. Finally, by calculating the step line tension at different temperatures, we were able to make a direct comparison with available experimental data.

  10. The pre therapeutic PET-F.D.G. predicts the survival in the high grade gliomas independently of consensual prognosis factors; La TEP-FDG pretherapeutique predit la survie dans les gliomes de haut grade independamment des facteurs pronostiques consensuels

    Energy Technology Data Exchange (ETDEWEB)

    Colavolpe, C.; Guedj, E.; Mancini, J.; Bequet-Boucard, C.; Metellus, P.; Barrie, M.; Figarella-Branger, D.; Chinot, O.; Mundler, O. [CHU La Timone, Marseille, (France)

    2009-05-15

    The objective of this study is to evaluate the prognosis value independent of the pre-therapy PET-F.D.G. on the global survival and without progression of high grade gliomas, in comparison with the consensual prognosis factors. In conclusion, the comparison between the tumor and contralateral maximal fixation on the preoperative PET-F.D.G. brings a supplementary prognosis information for the management of high grade gliomas, independently of the consensual prognosis factors. (N.C.)

  11. Deciphering PDT-induced inflammatory responses using real-time FDG-PET in a mouse tumour model.

    Science.gov (United States)

    Cauchon, Nicole; Hasséssian, Haroutioun M; Turcotte, Eric; Lecomte, Roger; van Lier, Johan E

    2014-10-01

    Dynamic positron emission tomography (PET), combined with constant infusion of 2-deoxy-2-[(18)F]fluoro-d-glucose (FDG), enables real-time monitoring of transient metabolic changes in vivo, which can serve to understand the underlying physiology. Here we investigated characteristic changes in the tumour FDG-uptake profiles in relation to acute localized inflammatory responses induced by photodynamic therapy (PDT). Dynamic PET imaging with constant FDG infusion was used with EMT-6 tumour bearing mice. FDG time-activity uptake curves were measured simultaneously, in treated and reference tumours, for 3 hours, before, during and after PDT light treatment. Inflammation was studied when evoked, either by PDT using a trisulfonated porphyrazine photosensitizer, or lipopolysaccharide (LPS), and inhibited using indomethacin. The distinct transient patterns, characterized by drops and subsequent recovery of tumour FDG uptake rates, were also analysed using immunohistochemical markers for apoptosis, necrosis, and inflammation. Typical profiles for tumour FDG-uptake, consisted of a drop during PDT, followed by a gradual recovery period. Tumours treated with LPS, but not with light, showed a continuous increase in FDG-uptake during the 3 h experimental period. Treatment with indomethacin, inhibited the rise in FDG-uptake observed with either LPS or PDT. Tumour FDG-uptake profiles correlated with necrosis markers during PDT, and inflammatory response markers post-PDT, but not with an apoptosis marker at any time during or after PDT. Dynamic FDG-PET imaging combined with indomethacin reveals that, the drop in the tumour FDG-uptake rate during the PDT illumination phase reflects vascular collapse and necrosis, while the increased tumour FDG-uptake rate immediately post-illumination involves an acute localized inflammatory response. Dynamic FDG infusion and PET imaging, combined with the use of selective inhibitors, provides unique insight for deciphering the complex underlying

  12. Integrated FDG-PET/CT for detection, therapy monitoring and follow-up of granulocytic sarcoma. Initial results

    Energy Technology Data Exchange (ETDEWEB)

    Aschoff, Philip; Werner, M.K.; Lichy, M.; Pfannenberg, C. [Dept. of Diagnostic and Interventional Radiology, Univ. Hospital, Eberhard-Karls-Univ. Tuebingen (Germany); Haentschel, M.; Vogel, W. [Dept. of Internal Medicine, Univ. Hospital, Eberhard-Karls-Univ. Tuebingen (Germany); Oeksuez, M. [Dept. of Nuclear Medicine, Univ. Hospital, Eberhard-Karls-Univ. Tuebingen (Germany)

    2009-07-01

    Granulocytic sarcomas (GS) are rare extramedullary manifestations of myeloid or lymphoblastic leukaemia. Laboratory examinations are of limited use for diagnosis of extramedullary disease. Radiological imaging based on morphology is challenging. To date, the possible role of FDG-PET/CT as a method for combined metabolic and morphologic imaging is unclear. We present a series of 10 patients to evaluate the potential role of FDG-PET/CT in the management of GS. Patients, materials, methods: a retrospective evaluation of 18 FDG-PET/CT exams in 10 patients with histologically proven GS was performed. All scans included a contrast enhanced CT. The FDG uptake of GS was analyzed and the sensitivity of lesion detection was compared to PET and CT alone. The changes in FDG uptake after therapy were compared to morphological changes detected by CT and follow-up/clinical outcome. Results: 52 untreated or recurrent GS lesions were detected by FDG-PET/CT and all showed an increased FDG uptake with a mean SUVmax and SUVavg of 5.1 and 3.4, respectively. GS was multifocal in 8/10 patients. Combined PET/CT avoided 5 false positive findings compared to PET alone and 13 false negative findings and 1 false positive compared to CT alone. Changes in FDG uptake after therapy correlated with clinical outcome and were more reliable than CT assessment alone. PET/CT identified recurrent GS in 3 patients. Conclusion: viable GS are FDG-avid. Using this metabolic information and morphologic CT criteria, combined FDG-PET/CT was more accurate in lesion detection than FDG-PET or CT alone. Changes in FDG uptake after therapy might be a useful additional parameter for therapy monitoring. Therefore, FDG-PET/CU appears to be a promising diagnostic and monitoring tool in the management of patients with GS. (orig.)

  13. Discussion on the alteration of FDG uptake by the breast according to the menstrual cycle in 18F-FDG PET/CT

    Science.gov (United States)

    Park, H. H.; Park, M. S.; Lee, C. H.; Cho, J. H.; Dong, K. R.; Chung, W. K.

    2012-09-01

    18F-FDG (fluorodeoxyglucose) PET (positron emission tomography)/CT (computed tomography) is a useful modality for identifying high-glucose-consuming cells, such as cancer cells, by the glucose metabolism of FDG. FDG is taken up by cancer and inflammatory cells, but occasionally there is also some FDG uptake by normal tissues as a result of their individual physiological characteristics. In particular, in fertile females, unusual FDG uptake in the breast changes according to the stages in the menstrual cycle, which can adversely affect a diagnosis. Therefore, this study examined the change in breast FDG uptake in the menstrual cycle on 18F-FDG PET/CT. One hundred and sixty females (34±3.5 years old), who had not undergone a gynecologic anamnesis and had a regular menstrual cycle over the previous 6 months, were examined from March 2010 to February 2011. The subjects were divided into the following four groups (each with 40 patients): flow phase, proliferative phase, ovulatory phase and secretory phase using Pregnancy Calculator Ver. 0.14 and history taking. Discovery Ste was used as the PET/CT. The standardized uptake values (SUVs) on the accumulated region on the breast were analyzed, and three nuclear medicine specialists performed a blind test. The SUVs on the breast were the flow phase (1.64±0.25), proliferative phase (0.93±0.28), ovulatory phase (1.66±0.26) and secretory phase (1.77±0.28). A high uptake value was observed in the secretory, flow and ovulatory phases. The FDG accumulation of the breast was divided into the following three grades compared with the lung and liver by gross analysis: the breast uptake was equal to the lung (Grade I), between the lung and liver (Grade II) and equal to or greater than the liver (Grade III). These results showed a high uptake value in the secretory, flow and ovulatory phases. In fertile females, the FDG uptake of the breast showed changes according to the menstrual cycle, which can be used to improve the diagnosis

  14. [{sup 18}F]FDG PET/CT outperforms [{sup 18}F]FDG PET/MRI in differentiated thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Vrachimis, Alexis; Wenning, Christian; Weckesser, Matthias; Stegger, Lars [University Hospital Muenster, Department of Nuclear Medicine, Muenster (Germany); Burg, Matthias Christian; Allkemper, Thomas [University Hospital Muenster, Department of Clinical Radiology, Muenster (Germany); Schaefers, Michael [University Hospital Muenster, Department of Nuclear Medicine, Muenster (Germany); Westfaelische Wilhelms University Muenster, European Institute for Molecular Imaging, Muenster (Germany)

    2016-02-15

    To evaluate the diagnostic potential of PET/MRI with [{sup 18}F]FDG in comparison to PET/CT in patients with differentiated thyroid cancer suspected or known to have dedifferentiated. The study included 31 thyroidectomized and remnant-ablated patients who underwent a scheduled [{sup 18}F]FDG PET/CT scan and were then enrolled for a PET/MRI scan of the neck and thorax. The datasets (PET/CT, PET/MRI) were rated regarding lesion count, conspicuity, diameter and characterization. Standardized uptake values were determined for all [{sup 18}F]FDG-positive lesions. Histology, cytology, and examinations before and after treatment served as the standards of reference. Of 26 patients with a dedifferentiated tumour burden, 25 were correctly identified by both [{sup 18}F]FDG PET/CT and PET/MRI. Detection rates by PET/CT and PET/MRI were 97 % (113 of 116 lesions) and 85 % (99 of 113 lesions) for malignant lesions, and 100 % (48 of 48 lesions) and 77 % (37 of 48 lesions) for benign lesions, respectively. Lesion conspicuity was higher on PET/CT for both malignant and benign pulmonary lesions and in the overall rating for malignant lesions (p < 0.001). There was a difference between PET/CT and PET/MRI in overall evaluation of malignant lesions (p < 0.01) and detection of pulmonary metastases (p < 0.001). Surgical evaluation revealed three malignant lesions missed by both modalities. PET/MRI additionally failed to detect 14 pulmonary metastases and 11 benign lesions. In patients with thyroid cancer and suspected or known dedifferentiation, [{sup 18}F]FDG PET/MRI was inferior to low-dose [{sup 18}F]FDG PET/CT for the assessment of pulmonary status. However, for the assessment of cervical status, [{sup 18}F]FDG PET/MRI was equal to contrast-enhanced neck [{sup 18}F]FDG PET/CT. Therefore, [{sup 18}F]FDG PET/MRI combined with a low-dose CT scan of the thorax may provide an imaging solution when high-quality imaging is needed and high-energy CT is undesirable or the use of a contrast

  15. Significance of FDG-PET in Identification of Diseases of the Appendix – Based on Experience of Two Cases Falsely Positive for FDG Accumulation

    Directory of Open Access Journals (Sweden)

    Shimpei Ogawa

    2009-04-01

    Full Text Available A discussion of the significance of F-fluorodeoxyglucose positron emission tomography (FDG-PET in the identification of diseases of the appendix is presented based on two cases falsely positive for FDG accumulation. Both cases were palpable for a tumor in the lower right abdominal region and a prominently enlarged appendix was depicted by CT. Although the patients underwent ileocecal resection based on a strong suspicion of appendiceal cancer rather than appendicitis since abnormal accumulation exhibiting maximum standard uptake values (SUVs of 7.27 and 17.11, respectively, was observed at the same site in FDG-PET examination and since there no malignant findings observed histologically, the patients were diagnosed with appendicitis. Although FDG specifically accumulates not only in malignant tumors, but also in diseases such as acute or chronic inflammation, abscesses and lymphadenitis, and identification based on SUVs has been reported to be used as a method of identification, the two cases reported here were both false-positive cases exhibiting high maximum SUVs. At the present time, although the significance of FDG-PET in the identification of diseases of the appendix is somewhat low and there are limitations on its application, various research is currently being conducted with the aim of improving diagnostic accuracy, and it is hoped that additional studies will be conducted in the future.

  16. Au36(SPh)23 nanomolecules.

    Science.gov (United States)

    Nimmala, Praneeth Reddy; Dass, Amala

    2011-06-22

    A new core size protected completely by an aromatic thiol, Au(36)(SPh)(23), is synthesized and characterized by MALDI-TOF mass spectrometry and UV-visible spectroscopy. The synthesis involving core size changes is studied by MS, and the complete ligand coverage by aromatic thiol group is shown by NMR.

  17. Has endoscopic (TEP, TAPP) or open inguinal hernia repair a higher risk of bleeding in patients with coagulopathy or antithrombotic therapy? Data from the Herniamed Registry.

    Science.gov (United States)

    Köckerling, F; Roessing, C; Adolf, D; Schug-Pass, C; Jacob, D

    2016-05-01

    Inguinal hernia operations in the presence of antithrombotic therapy, based on antiplatelet or anticoagulant drugs, or existing coagulopathy are associated with a markedly higher risk for onset of postoperative secondary bleeding. To date, there is a paucity of concrete data on this important clinical aspect of inguinal hernia surgery. Up till now, the endoscopic (TEP, TAPP) techniques have been considered to be more risky because of the extensive dissection involved. Out of the 82,911 patients featured in the Herniamed Hernia Registry who had undergone inguinal hernia repair, 9115 (11 %) were operated on while receiving antithrombotic therapy or with existing coagulopathy. The implications of that risk profile for onset of postoperative bleeding were investigated in multivariable analysis. In addition, other influence variables were identified. The rate of postoperative secondary bleeding, at 3.91 %, was significantly higher in the risk group with coagulopathy or receiving antithrombotic therapy than in the group without that risk profile at 1.12 % (p TEP, TAPP) inguinal hernia repair, the risk of bleeding complications and complication-related reoperation appears to be lower.

  18. Evaluation of thymic tumors with 18F-FDG PET-CT - A pictorial review

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Punit; Singhal, Abhinav; Bal, Chandrasekhar; Malhotra, Arun; Kumar, Rakesh [Dept. of Nuclear Medicine, All India Inst. of Medical Sciences, New Delhi (India)], e-mail: rkphulia@yahoo.com; Kumar, Arvind [Dept. of Surgical Disciplines, All India Inst. of Medical Sciences, New Delhi (India)

    2013-02-15

    Thymic tumors represent a broad spectrum of neoplastic disorders and pose considerable diagnostic difficulties. A non-invasive imaging study to determine the nature of thymic lesions can have significant impact on management of such tumors. 18F-flurorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) has shown promising results in characterization of thymic tumors. The objective of this article is to provide an illustrative tutorial highlighting the clinical utility of 18F-FDG PET-CT imaging in patients with thymic tumors. We have pictorially depicted the 18F-FDG PET-CT salient imaging characteristics of various thymic tumors, both epithelial and non-epithelial. Also discussed is the dynamic physiology of thymus gland which is to be kept in mind when evaluating thymic pathology on 18F-FDG PET-CT, as it can lead to interpretative pitfalls.

  19. Pancreatic involvement detected with (18)F-FDG PET/CT in disseminated sarcoidosis.

    Science.gov (United States)

    Delgado-Bolton, R C; Arias Navalón, J A; Rodríguez Alfonso, B; Delgado-Bolton, A N; Pérez-Castejón, M J; Sánchez-Escribano, R; Cabrera Martín, M N; Lapeña Gutiérrez, L; Carreras Delgado, J L

    2011-01-01

    La sarcoidosis is a granulomatous disease of unknown etiology. It may mimic malignancy and may affect multiple organs, with a variable clinical course. Pancreatic involvement is very rare. We present the case of a 78-year-old woman with systemic sarcoidosis whose (18)F-FDG PET/CT scan showed a pancreatic lesion and multiple lymphatic (thoracic and non-thoracic) and visceral lesions. The abnormal (18)F-FDG uptake in the pancreas was limited to the tail. A second (18)F-FDG PET/CT study performed 4 months and 3 weeks after the first PET/CT, following corticosteroid therapy during three and a half months, evidenced partial regression of the disease, with persistent (18)F-FDG pathological uptake in the pancreatic lesion. Copyright © 2010 Elsevier España, S.L. and SEMNIM. All rights reserved.

  20. Dose painting based on tumor uptake of Cu-ATSM and FDG

    DEFF Research Database (Denmark)

    Clausen, Malene Martini; Hansen, Anders Elias; Lundemann, Michael

    2014-01-01

    definitions based on FDG, 64Cu-ATSM 3 h and 24 h uptake in canine tumors had different localization of the regional dose escalation levels. This indicates that 64Cu-ATSM at two different time-points and FDG provide different biological information that has to be taken into account when using the dose painting......Background: Hypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deoxy-2-[18 F]- fluorodeoxyglucose (FDG) and the proposed hypoxia tracer, copper......(II)diacetyl-bis(N4)-methylsemithiocarbazone (Cu-ATSM) using spontaneous clinical canine tumor models. Methods: Positron emission tomography/computed tomography scans of five spontaneous canine sarcomas and carcinomas were obtained; FDG on day 1 and 64Cu-ATSM on day 2 and 3 (approx. 3 and 24 hours pi.). Sub...

  1. The Values and Limitations of FDG-PET/CT for Diagnosis of Hibernoma

    Directory of Open Access Journals (Sweden)

    Jong Hoon Park

    2015-01-01

    Full Text Available Hibernoma is a rare benign lipogenic tumor of brown fat that develops in a wide variety of locations. Although the features of hibernoma demonstrated by MRI resemble those of liposarcoma, recent FDG-PET/CT studies have documented higher radiotracer uptake than liposarcoma, suggesting that FDG/PET/CT is useful for differentiating hibernoma from liposarcoma. Here we report two cases of hibernoma that showed relatively lower SUVs than those reported previously, lying within the range for liposarcoma. Our findings emphasize that hibernoma needs to be included in the differential diagnosis of any fat-containing tumor showing intense accumulation by FDG-PET/CT. Although it is unlikely that such a rare condition could be reasonably diagnosed on the basis of MRI and FDG-PET/CT alone due to possible SUV overlap between hibernoma and liposarcoma, it is important to recognize this extremely rare lipogenic tumor for accurate diagnosis and appropriate management.

  2. Aneurysmal angiosarcoma associated with vascular graft revealed by 18F-FDG-PET imaging.

    Science.gov (United States)

    Chetouani, Ahmed; Perrin, Mathieu; Drouet, Clément; Marie, Pierre-Yves; Verger, Antoine

    2017-06-01

    We report a rare case of vascular graft-associated aneurysmal angiosarcoma by 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET). An 81-year-old male patient, with a prior history of graft interposition 1 year previously, was referred to 18F-FDG-PET because of an inflammatory syndrome of unknown origin. FDG-PET images revealed a particular pattern of intense circular uptake within the arterial wall (SUVmax = 10) in a popliteal aneurysm and, additionally, a large hypermetabolic mass centered by the graft. Remote hypermetabolisms in lung nodules and pleural thickenings were also detected. The diagnosis of angiosarcoma was ascertained through histopathological analysis of surgical samples. Development of an aneurysmal angiosarcoma at the site of a vascular graft is a rare entity, often misdiagnosed. 18F-FDG-PET appears to be useful in its detection with a PET pattern of intense circular uptake within the arterial wall. Such finding should lead to the search for distant metastasis.

  3. The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer

    Directory of Open Access Journals (Sweden)

    ZHOU Ming

    2016-02-01

    Full Text Available As an important complementary imaging agent for 18F-FDG, 18F-fluoroethyl-choline (18F-FECH has been demonstrated to be promising in brain and prostate cancer imaging. By using domestic PET-FDG-TI-I CPCU synthesizer, 18F-FECH was synthesized by different reagents and consumable supplies. The C18 column was added before the product collection bottle to remove K2.2.2. The 18F-FECH was synthesized by PET-FDG-IT-I synthesizer efficiently about 30 minutes by radiochemical yield of 42.0% (no decay corrected, n=5, and the radiochemical purity was still more than 99.0% after 6 hours. The results showed the domestic PET-FDG-IT-I synthesizer could semi-automatically synthesize injectable 18F-FECH in high efficiency and radiochemical purity

  4. {sup 18}F-FDG in distinction of atherosclerotic plaque: Innovation in PET/MRI technology

    Energy Technology Data Exchange (ETDEWEB)

    Benedetto, Raquel; Fonseca, Lea Mirian Barbosa da, E-mail: benedettoraquel@yahoo.com.b [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil); Carneiro, Michel Pontes; Junqueira, Flavia Albuquerque; Coutinho Junior, Antonio [Clinica de Diagnostico por Imagem (CDPI), Rio de Janeiro, RJ (Brazil); Ristow, Arno von [Centervasc, Rio de Janeiro, RJ (Brazil)

    2009-12-15

    The glucose analogue, {sup 18}F-FDG, can be used to image inflammatory cell activity non-invasively by PET. In the present study, we investigate the possibility of using {sup 18}F-FDG to characterize atherosclerotic plaques. A 77-year-old man with symptomatic carotid atherosclerosis was imaged using {sup 18}F-FDG-PET and co-registered MRI. A plaque with intense fibrotic and necrotic content was obtained. Due to the fact that the tissue showed up as inactive, according to the metabolic activity, it was not possible to observe {sup 18}F-FDG uptake. Our aim was to confirm that it could be clinically used to predict the inflammatory activity of the plaque. (author)

  5. 18F-FDG-PET/CT in fever of unknown origin

    DEFF Research Database (Denmark)

    Middelbo Buch-Olsen, Karen; Andersen, Rikke V; Hess, Søren

    2014-01-01

    OBJECTIVE: Fever of unknown origin continues to be a diagnostic challenge for clinicians. The aim of this study was to confirm whether (18)F-fluorodeoxyglucose ((18)F-FDG)-PET/computed tomography (CT) is a helpful tool in patients suffering from this condition. PATIENTS AND METHODS: Fifty......-seven patients with fever of unknown origin were examined with (18)F-FDG-PET/CT as part of their diagnostic workup at the clinicians' discretion. The medical records were read retrospectively to establish the final diagnosis and evaluate the degree to which PET/CT contributed to the diagnosis. RESULTS...... towards an organ not regarded by the clinicians as being related to the final diagnosis. It was perceived not helpful if the cause of fever was not visible on (18)F-FDG-PET/CT. We found (18)F-FDG-PET/CT helpful in 75% of patients, not helpful in 4%, and false positive in 21% of patients. CONCLUSION: (18)F...

  6. The nuclear physician does not include skull in PET. Should he change his habits?; Le medecin nucleaire ne crane pas en TEP. Doit-il changer ses habitudes?

    Energy Technology Data Exchange (ETDEWEB)

    Bondouy, M.; Serrano, B.; Verge, M.; Rigo, P. [centre hospitalier Princesse-Grace, Service de medecine nucleaire (Monaco)

    2010-07-01

    This study shows there is interest to include the skull in the field of view when performing a PET / CT {sup 18}-F.D.G. with a new generation unit at the cost of low radiation doses and an insignificant increased time. (N.C.)

  7. Recurrent renal cell carcinoma: clinical and prognostic value of FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Alongi, Pierpaolo; Picchio, Maria; Gianolli, Luigi [IRCCS San Raffaele Scientific Institute, Nuclear Medicine Department, Milan (Italy); Zattoni, Fabio [University of Padua, Department of Oncological and Surgical Sciences, Urology Clinic, Padua (Italy); Spallino, Marianna [University of Milano-Bicocca, Milan (Italy); Saladini, Giorgio; Evangelista, Laura [Veneto Institute of Oncology IOV - IRCCS, Padua, Italy, Radiotherapy and Nuclear Medicine Unit, Padua (Italy)

    2016-03-15

    The purpose of our study was 1) to evaluate the diagnostic performance of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT), 2) to assess the impact of FDG PET/CT on treatment decision-making, and 3) to estimate the prognostic value of FDG PET/CT in the restaging process among patients with renal cell carcinoma (RCC). From the FDG PET/CT databases of San Raffaele Hospital in Milan, Italy, and the Veneto Institute of Oncology in Padua, Italy, we selected 104 patients with a certain diagnosis of RCC after surgery, and for whom at least 24 months of post-surgical FDG PET/CT, clinical, and instrumental follow-up data was available. The sensitivity and specificity of FDG PET/CT were assessed by histology and/or other imaging as standard of reference. Progression-free survival (PFS) and overall survival (OS) were computed using the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards models were used to identify predictors of outcome. FDG PET/CT resulted in a positive diagnosis in 58 patients and a negative diagnosis in 46 patients. Sensitivity and specificity were 74 % and 80 %, respectively. FDG PET/CT findings influenced therapeutic management in 45/104 cases (43 %). After a median follow-up period of 37 months (± standard deviation 12.9), 51 (49 %) patients had recurrence of disease, and 26 (25 %) had died. In analysis of OS, positive versus negative FDG PET/CT was associated with worse cumulative survival rates over a 5-year period (19 % vs. 69 %, respectively; p <0.05). Similarly, a positive FDG PET/CT correlated with a lower 3-year PFS rate. In addition, univariate and multivariate analysis revealed that a positive scan, alone or in combination with disease stage III-IV or nuclear grading 3-4, was associated with high risk of progression (multivariate analysis = hazard ratios [HRs] of 4.01, 3.7, and 2.8, respectively; all p < 0.05). FDG PET/CT is a valuable tool both in treatment decision-making and for

  8. Comparison of (18)F-FET and (18)F-FDG PET in brain tumors.

    Science.gov (United States)

    Pauleit, Dirk; Stoffels, Gabriele; Bachofner, Ansgar; Floeth, Frank W; Sabel, Michael; Herzog, Hans; Tellmann, Lutz; Jansen, Paul; Reifenberger, Guido; Hamacher, Kurt; Coenen, Heinz H; Langen, Karl-Josef

    2009-10-01

    The purpose of this study was to compare the diagnostic value of positron emission tomography (PET) using [(18)F]-fluorodeoxyglucose ((18)F-FDG) and O-(2-[(18)F]fluoroethyl)-l-tyrosine ((18)F-FET) in patients with brain lesions suspicious of cerebral gliomas. Fifty-two patients with suspicion of cerebral glioma were included in this study. From 30 to 50 min after injection of 180 MBq (18)F-FET, a first PET scan ((18)F-FET scan) was performed. Thereafter, 240 MBq (18)F-FDG was injected and a second PET scan was acquired from 30 to 60 min after the second injection ((18)F-FET/(18)F-FDG scan). The cerebral accumulation of (18)F-FDG was calculated by decay corrected subtraction of the (18)F-FET scan from the (18)F-FET/(18)F-FDG scan. Tracer uptake was evaluated by visual scoring and by lesion-to-background (L/B) ratios. The imaging results were compared with the histological results and prognosis. Histology revealed 24 low-grade gliomas (LGG) of World Health Organization (WHO) Grade II and 19 high-grade gliomas (HGG) of WHO Grade III or IV, as well as nine others, mainly benign histologies. The gliomas showed increased (18)F-FET uptake (>normal brain) in 86% and increased (18)F-FDG uptake (>white matter) in 35%. (18)F-FET PET provided diagnostically useful delineation of tumor extent while this was impractical with (18)F-FDG due to high tracer uptake in the gray matter. A local maximum in the tumor area for biopsy guidance could be identified with (18)F-FET in 76% and with (18)F-FDG in 28%. The L/B ratios showed significant differences between LGG and HGG for both tracers but considerable overlap so that reliable preoperative grading was not possible. A significant correlation of tracer uptake with overall survival was found with (18)F-FDG only. In some benign lesions like abscesses, increased uptake was observed for both tracers indicating a limited specificity of both techniques. (18)F-FET PET is superior to (18)F-FDG for biopsy guidance and treatment planning of

  9. FDG uptake after intraarterial chemotherapy in head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Doebert, N. [Univ. Hospital Frankfurt am Main (Germany). Dept. of Nuclear Medicine; Gemeinschaftspraxis Nuklearmedizin, Darmstadt (Germany); Kovacs, A.F. [Univ. Hospital Frankfurt am Main (Germany). Dept. of Maxillofacial Plastic Surgery; Menzel, C.; Kranert, W.T.; Gruenwald, F. [Univ. Hospital Frankfurt am Main (Germany). Dept. of Nuclear Medicine; Engels, K. [Senckenberg Dept. of Pathology, Univ. Hospital Frankfurt am Main (Germany)

    2006-07-01

    Aim: the intraarterial chemotherapy (i.a.CHT) using high dose cisplatin combined with systemic neutralization in patients with head and neck cancer (HNSCC) is used to reduce the tumor volume preoperatively. Aim of the study is the evaluation of the influence of i.a.CHT on the metabolism of fluor-18-deoxyglucose (FDG) in the primary and lymph nodes (LN). The value of FDG positron emission tomography (PET) preoperative and as follow-up method otter i.a.CHT is examined. Patients, methods: altogether 16 patients with HNSCC underwent two preoperative FDG PET examinations: the baseline examination one week before and the follow-up three weeks after i.a.CHT. The SUVmax values of the primary and the IN and LN metastases were evaluated and compared with each other and the histopathology. Results: the SUVmax value of the primary decreased after i.a.CHT significantly from a median (25{sup th} percentile/ 75{sup th} percentile) of 6.4 (4.1/ 7.8) to 3.6 (2.4/ 6.7) (p = 0.01). In 11 out of 16 patients cervical LN metastases were detected. The cervical LN metastases showed a decrease of the SUVmax value from 3.6 (2.3/ 4.8) in the pretreatment examination to 2.3 (1.7/ 3.6) after i.a.CHT (p = 0,008). Only in one patient with LN metastases the SUVmax of the nodes increased. The histopathologically measured size of the LN metastases ranged from 2 to 30 mm. Non malignant LN did not reveal a significant SUVmax decrease after i.a.CHT (p = 0.13). Conclusions: as expected, primaries of HNSCC showed a significant reduction of SUV after i.a.CHT. Compared to the primary the SUVmax decrease in LN metastases was less, but also significant. Since cytotoxic levels of cisplatin do not occur systemic, postinflammatory reactions of the LN or a lymphatic drainage of the chemotherapeutic drug into the LN could be an explanation. PET for staging of HNSCC must thus be performed prior to i.a.CHT. (orig.)

  10. Monitoring isotretinoin therapy in thyroid cancer using {sup 18}F-FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Boerner, A.R.; Petrich, T.; Weckesser, E.; Fricke, H.; Hofmann, M.; Otto, D.; Knapp, W.H. [Department of Nuclear Medicine, Hannover Medical School (Germany); Weckesser, M. [Department of Nuclear Medicine, University of Muenster (Germany); Langen, K.J. [Institute of Medicine, Research Centre Juelich, Juelich (Germany)

    2002-02-01

    Treatment with isotretinoin (13-cis-retinoic acid, 13-cis-RA) is a recent additional option in advanced, otherwise intractable differentiated thyroid cancers. The aim of this study was to evaluate fluorine-18 fluorodeoxyglucose positron emission tomography ({sup 18}F-FDG PET) in the prediction and the monitoring of response to 13-cis-RA therapy. Twenty-one patients with advanced differentiated thyroid cancers were investigated using {sup 18}F-FDG PET and iodine-131 whole-body scans before and 3, 6 and 9 months after initiation of 13-cis-RA therapy. After 9 months, 13-cis-RA treatment was discontinued and imaging procedures repeated 3 months later. Average {sup 18}F-FDG uptake (SUV) decreased significantly during 13-cis-RA therapy but subsequently increased in five of eight patients after withdrawal of 13-cis-RA. {sup 18}F-FDG uptake (SUV) 3 months after onset of 13-cis-RA therapy was significantly lower in patients who developed increased {sup 131}I uptake in their tumour sites than in patients with no subsequent increase in {sup 131}I uptake. There was no relationship between serum thyroglobulin level on the one hand and simultaneously measured {sup 131}I or {sup 18}F-FDG uptake on the other hand. There was a tendency towards lower {sup 18}F-FDG uptake in tumour manifestations with a better outcome. Therefore, {sup 18}F-FDG PET at 3 months after the start of treatment promises to differentiate between those patients who will eventually benefit from 13-cis-RA and those who will not. In conclusion, these data indicate that {sup 18}F-FDG PET is a useful tool for the evaluation and monitoring of adjuvant therapy with 13-cis-RA in thyroid cancer. (orig.)

  11. Clinical Application of {sup 18}F-FDG PET in Nonmelanomatous Skin Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Joon Kee [Ajou University School of Medicine, Suwon (Korea, Republic of)

    2008-12-15

    Nonmelanomatous skin cancer includes basal cell carcinoma, squamous cell carcinoma, merkel cell carcinoma and dermatofibrosarcoma protuberance. So far, there have been a few reports that {sup 18}F-FDG PET was useful in the evaluation of metastasis and therapeutic response in nonmelanomatous skin cancer, however, those are very weak evidences. Therefore, further studies on the usefulness of {sup 18}F-FDG PET in nonmelanomatous skin cancer are required.

  12. A simple method for the quality control of [F-18]FDG

    DEFF Research Database (Denmark)

    Koziorowski, J.

    2010-01-01

    Most automated synthesis modules produce [F-18]FDG within half an hour, but the quality control involving up to three separate methods and three different analytical systems is time consuming. The use of HPLC, TLC, and GC for the quality control of [F-18]FDG is both time consuming and expensive...... (high purchase costs). Presented here is a method using a single HPLC system for all three analyses. (C) 2010 Elsevier Ltd. All rights reserved...

  13. In vivo ¹⁸F-FDG tumour uptake measurements in small animals using Cerenkov radiation.

    Science.gov (United States)

    Boschi, Federico; Calderan, Laura; D'Ambrosio, Daniela; Marengo, Mario; Fenzi, Alberto; Calandrino, Riccardo; Sbarbati, Andrea; Spinelli, Antonello E

    2011-01-01

    2-[(18)F]Fluoro-2-deoxy-D-glucose ((18)F-FDG) is a widely used PET radiotracer for the in vivo diagnosis of several diseases such as tumours. The positrons emitted by (18)F-FDG, travelling into tissues faster than the speed of light in the same medium, are responsible for Cerenkov radiation (CR) emission which is prevalently in the visible range. The purpose of this study is to show that CR escaping from tumour tissues of small living animals injected with (18)F-FDG can be detected with optical imaging (OI) techniques using a commercial optical instrument equipped with charge-coupled detectors (CCD). The theory behind the Cerenkov light emission and the source depth measurements using CR is first presented. Mice injected with (18)F-FDG or saline solution underwent dynamic OI acquisition and a comparison between images was performed. Multispectral analysis of the radiation was used to estimate the depth of the source of Cerenkov light. Small animal PET images were also acquired in order to compare the (18)F-FDG bio-distribution measured using OI and PET scanner. Cerenkov in vivo whole-body images of tumour-bearing mice and the measurements of the emission spectrum (560-660 nm range) are presented. Brain, kidneys and tumour were identified as a source of visible light in the animal body: the tissue time-activity curves reflected the physiological accumulation of (18)F-FDG in these organs. The identification is confirmed by the comparison between CR and (18)F-FDG images. These results will allow the use of conventional OI devices for the in vivo study of glucose metabolism in cancer and the assessment, for example, of anti-cancer drugs. Moreover, this demonstrates that (18)F-FDG can be employed as it is a bimodal tracer for PET and OI techniques.

  14. A Monte Carlo studies of the entrance foil material in a target assembly for FDG production

    Energy Technology Data Exchange (ETDEWEB)

    Merouani, A.; El Khayati, N. [Nuclear Physics Laboratory, Faculty of Science, Mohammed V University, Rabat (Morocco); EL Ghayour, A.; El Alamy, H.; Zoubir, B. [Cyclopharma, Bouskoura, Casablanca (Morocco)

    2015-07-01

    In this work, a Monte Carlo simulation was performed for different entrance foil Materials in the target assembly for [{sup 18}F] FDG production, to investigate the neutron generations in the entrance foil. However, the objective is to study a materials that has the more or less similar mechanical properties as the Havar{sup R} foil with less generation of secondary particles and without affecting, the yield of FDG production. (authors)

  15. Steam sterilization and automatic dispensing of [{sup 18}F]fludeoxyglucose (FDG) for injection

    Energy Technology Data Exchange (ETDEWEB)

    Karwath, Pascal [Department of Nuclear Medicine, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn (Germany) and MC-Pharma GmbH (MCP), Bonn (Germany)]. E-mail: p.karwath@uni-bonn.de; Sartor, Johannes [MC-Pharma GmbH (MCP), Bonn (Germany); Gries, Wolfgang [MC-Pharma GmbH (MCP), Bonn (Germany); Wodarski, Christine [MC-Pharma GmbH (MCP), Bonn (Germany); Dittmar, Claus [MC-Pharma GmbH (MCP), Bonn (Germany); Biersack, Hans J. [Department of Nuclear Medicine, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn (Germany); Guhlke, Stefan [Department of Nuclear Medicine, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn (Germany) and MC-Pharma GmbH (MCP), Bonn (Germany)]. E-mail: stefan.guhlke@ukb.uni-bonn.de

    2005-04-01

    For the purpose of implementing steam sterilization of 2-[{sup 18}F]FDG (FDG) in the final container into routine production, we have validated and established a fully automated dispensing and sterilization system, thereby considerably reducing the radiation burden to the personnel. Methods: The commercially available system combines aseptic dispensing of the product solution under a miniaturized laminar flow unit with subsequent steam sterilization, realized by heating of the product in the final containers by an autoclave included in the dispensing unit, thus incorporating current pharmaceutical manufacturing standards for the production of parental radiopharmaceuticals. The efficiency of the used sterilization cycle, the stability of FDG under the conditions of sterilization and the stability of the final product towards radiolysis was investigated with respect to various pH-formulations. Results: The system was found to be fully valid for filling of vials in a laminar flow class A (US-class 100) environment and for sterilization of FDG in the final container. The pH for sterilizing FDG solutions must be slightly acidic to avoid decomposition. A pH of 5.5 appears to be optimal and gives FDG of very high radiochemical purity ({approx}99%). In addition, radiolysis of FDG in solutions of high activity concentration was significantly lower at pH 5.5 than at neutral pH. Conclusion: Terminal sterilization enables the production of FDG in full compliance with GMP-regulations even in Class C or D (US class 10,000 or 100,000) laboratories.

  16. FDG PET/CT imaging in the diagnosis of osteomyelitis in the diabetic foot

    Energy Technology Data Exchange (ETDEWEB)

    Kagna, Olga; Keidar, Zohar [Rambam Health Care Campus, Department of Nuclear Medicine, POB 9602, Haifa (Israel); Srour, Saher; Militianu, Daniela [Rambam Health Care Campus, Department of Diagnostic Imaging, Haifa (Israel); Melamed, Eyal [Rambam Health Care Campus, Department of Orthopedics, Haifa (Israel)

    2012-10-15

    Osteomyelitis, the most serious complication of the diabetic foot, occurs in about 20 % of patients. Early diagnosis is crucial. Appropriate treatment will avoid or decrease the likelihood of amputation. The objective of this study was to assess the value of FDG PET/CT in diabetic patients with clinically suspected osteomyelitis. Enrolled in this prospective study were 39 consecutive diabetic patients (29 men and 10 women, mean age 57 years, range 28-71 years) with 46 suspected sites of foot infection. Of these 39 patients, 38 had type 2 and 1 type 1 diabetes for 4-25 years, and 28 were receiving treatment with insulin. FDG PET/CT was interpreted for the presence, intensity (SUVmax) and localization of increased FDG foci. Final diagnosis was based on histopathology and bacteriology of surgical samples, or clinical and imaging follow-up. Osteomyelitis was correctly diagnosed in 18 and excluded in 21 sites. Of 20 lesions with focal bone FDG uptake, 2 were false-positive with no further evidence of osteomyelitis. Five sites of diffuse FDG uptake involving more than one bone on CT were correctly diagnosed as diabetic osteoarthropathy. FDG PET/CT had a sensitivity, specificity and accuracy of 100 %, 92 % and 95 % in a patient-based analysis and 100 %, 93 % and 96 % in a lesion-based analysis, respectively, for the diagnosis of osteomyelitis in the diabetic foot. FDG PET/CT was found to have high performance indices for evaluation of the diabetic foot. The PET component identified FDG-avid foci in sites of acute infection which were precisely localized on fused PET/CT images allowing correct differentiation between osteomyelitis and soft-tissue infection. (orig.)

  17. Multivariat analyse av 18F-FDG PET av tre brystkreft-xenografter i mus

    OpenAIRE

    Skappel, Ingvild

    2015-01-01

    Denne masteroppgaven tar utgangspunkt i et studie hvor man har analysert bilder innhentet fra dynamisk PET (Positron Emission Tomography) av mus med implanterte menneskelige brystkreft-xenografter, utført ved Oslo Universitetssykehus i mars 2014. 2-deoksy-2-[18F]fluoro-D-glukose (FDG), en glukoseanalog merket med radioaktivt fluor (18F), er benyttet som tracer. Ved dynamisk FDG PET avbildes aktiviteten av 18F i kroppsvevet av interesse ved flere tidspunkt etter injeksjon av tracer. I denne op...

  18. Pyelo-cystic Reflux in F-18 FDG PET Scan Due to Ureteral Obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Reyhan, Mehmet [Baskent Univ., Adana (Turkmenistan)

    2013-09-15

    A 72-year-old woman with a history of cervical cancer was treated with brachytherapy and chemotherapy. Combined F-18 FDG PET/CT performed for restaging demonstrated increased FDG uptake in a hypodense cystic lesion at the posterior part of the right renal cortex and a hypermetabolic soft tissue mass at the right parailiac region suggestive of a metastatic lymph node causing ureteral obstruction. There had been no FDG uptake in the cystic lesion on the FDG PET/CT study performed 1 year before. These findings suggest that the increased FDG uptake in the cystic lesion was caused by pyelocystic reflux due to ureteral obstruction secondary to parailiac lymph node metastasis (Figs. 1 and 2). Several renal lesions may have increased metabolism, such as renal cell carcinoma, lymphoma, oncocytoma, adult Wilms' tumor, angiomyolipoma, metastatic lesions, xanthogranulo-matous pyelonephritis and infected cyst. Most of these lesions are solid. Some infected renal cysts may be FDG avid, but in this situation increased FDG uptake is observed on the wall of the cyst. In our case, FDG uptake was seen in the entire cystic lesion. The patient had no symptoms or laboratory findings related to infection. Cysts are the most common space-occupying lesions of the kidney. The vast majority of these are simple cysts that are usually unilateral and solitary. Simple cysts are asymptomatic, except when complications exist such as hemorrhage, infection or rupture. There have been a few reports on spontaneous communications between renal cysts and the pyelocaliceal system, in most cases involving ruptures of the cysts into the pyelocaliceal system due to increased intracystic pressure caused by bleeding or infection of the cyst. In the present case, the cause of the connection between the cystic cavity and the pyelocaliceal system is the increased pressure in the renal pelvic cavity due to the ureteral obstruction secondary to parailiac lymph node metastasis.

  19. (18)F-FDG PET/CT in a rare case of Stewart-Treves syndrome

    DEFF Research Database (Denmark)

    Jensen, Mads Radmer; Friberg, Lars; Karlsmark, Tonny

    2011-01-01

    The aim of this article is to illustrate the possible applications of (18)F-fluorodeoxyglucose positron emission tomography/computer tomography ((18)F-FDG PET/CT) in chronic extremity lymphedema and its complications.......The aim of this article is to illustrate the possible applications of (18)F-fluorodeoxyglucose positron emission tomography/computer tomography ((18)F-FDG PET/CT) in chronic extremity lymphedema and its complications....

  20. In vivo {sup 18}F-FDG tumour uptake measurements in small animals using Cerenkov radiation

    Energy Technology Data Exchange (ETDEWEB)

    Boschi, Federico; Calderan, Laura; Fenzi, Alberto; Sbarbati, Andrea [University of Verona, Department of Morphological-Biomedical Sciences, Section of Anatomy and Histology, Verona (Italy); D' Ambrosio, Daniela; Marengo, Mario [S. Orsola - Malpighi University Hospital, Medical Physics Department, Bologna (Italy); Calandrino, Riccardo; E Spinelli, Antonello [S. Raffaele Scientific Institute, Medical Physics Department, Milan (Italy)

    2011-01-15

    2-[{sup 18}F]Fluoro-2-deoxy-D-glucose ({sup 18}F-FDG) is a widely used PET radiotracer for the in vivo diagnosis of several diseases such as tumours. The positrons emitted by {sup 18}F-FDG, travelling into tissues faster than the speed of light in the same medium, are responsible for Cerenkov radiation (CR) emission which is prevalently in the visible range. The purpose of this study is to show that CR escaping from tumour tissues of small living animals injected with {sup 18}F-FDG can be detected with optical imaging (OI) techniques using a commercial optical instrument equipped with charge-coupled detectors (CCD). The theory behind the Cerenkov light emission and the source depth measurements using CR is first presented. Mice injected with {sup 18}F-FDG or saline solution underwent dynamic OI acquisition and a comparison between images was performed. Multispectral analysis of the radiation was used to estimate the depth of the source of Cerenkov light. Small animal PET images were also acquired in order to compare the {sup 18}F-FDG bio-distribution measured using OI and PET scanner. Cerenkov in vivo whole-body images of tumour-bearing mice and the measurements of the emission spectrum (560-660 nm range) are presented. Brain, kidneys and tumour were identified as a source of visible light in the animal body: the tissue time-activity curves reflected the physiological accumulation of {sup 18}F-FDG in these organs. The identification is confirmed by the comparison between CR and {sup 18}F-FDG images. These results will allow the use of conventional OI devices for the in vivo study of glucose metabolism in cancer and the assessment, for example, of anti-cancer drugs. Moreover, this demonstrates that {sup 18}F-FDG can be employed as it is a bimodal tracer for PET and OI techniques. (orig.)

  1. Clinical Significance of Myocardial Uptake on F-18 FDG PET/CT Performed in Oncologic Patients

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Ho Jin; Cho, Eung Hyuck; Lee, Jong Doo; Kang, Won Jun [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2009-12-15

    F-18 fluorodeoxyglucose (FDG) uptake of myocardium is influenced by various factors. Increased glycolysis, and subsequent increased F-18 FDG uptake has been reported in ischemic cardiomyopathy. However, clinical significance of incidentally found myocardial F-18 FDG uptake has not been clarified. We retrospectively reviewed the degree and pattern of myocardial uptake in patients without history of ischemic heart disease who underwent torso F-18 FDG PET/CT for evaluation of neoplastic disease. From January 2005 to June 2009, 77 patients who underwent F-18 FDG PET/CT and Tc-99m sestamibi stress/rest SPECT within 3 months were enrolled. Of 77 patients, 55 (71.4%) showed increased F-18 FDG uptake in the myocardium. In this population, 40 showed uniform uptake pattern, while 15 showed focal uptake. In patients with uniform uptake, 17 showed decreased uptake in the septum without perfusion defect on myocardial SPECT. Remaining 23 patients showed uniform uptake, with 1 reversible perfusion defect and 1 fixed perfusion defect. In 15 patients with focal uptake, 9 showed increased F-18 FDG uptake in the base, and only 1 of them showed reversible perfusion defect on myocardial SPECT. In the remaining 6 focal uptake group, 4 had reversible perfusion defect in the corresponding wall, and 1 had apical hypertrophy. We demonstrated that septal defect pattern and basal uptake pattern in the myocardium may represent normal variants. Focal myocardial uptake other than normal variants on oncologic torso F-18 FDG PET/CT with routine fasting protocol may suggest ischemic heart disease, thus further evaluation is warranted.

  2. 18F-FDG PET assessment of Lewy body dementia with cerebellar diaschisis.

    Science.gov (United States)

    Al-Faham, Zaid; Zein, Rami K; Wong, Ching-Yee Oliver

    2014-12-01

    Alzheimer disease and Lewy body dementia are the 2 most common causes of dementia. Each disease has distinctive regional metabolic reduction patterns on (18)F-FDG PET. In this report, we present a rare case of an elderly man with dementia whereby (18)F-FDG PET clearly showed Lewy body disease with crossed cerebellar diaschisis. © 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  3. A simple method for the quality control of [{sup 18}F]FDG

    Energy Technology Data Exchange (ETDEWEB)

    Koziorowski, J., E-mail: jacek@heh.regionh.d [Herlev Hospital, Copenhagen University, Dept. Clin. Phys. Nucl. Med., 54P1, Herlev Ringvej 75, DK-2730 Herlev (Denmark)

    2010-09-15

    Most automated synthesis modules produce [{sup 18}F]FDG within half an hour, but the quality control involving up to three separate methods and three different analytical systems is time consuming. The use of HPLC, TLC, and GC for the quality control of [{sup 18}F]FDG is both time consuming and expensive (high purchase costs). Presented here is a method using a single HPLC system for all three analyses.

  4. Correlation of primary tumor FDG uptake with histopathologic features of advanced gastric cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hae Won; Won, Kyoung Sook; Song, Bong Il; Kang, Yu Na [Keimyung University Dongsan Medical Center, Daegu (Korea, Republic of)

    2015-06-15

    Histopathologic features could affect the FDG uptake of primary gastric cancer and detection rate on FDG PET/CT. The aim of this study was to evaluate the FDG uptake of primary gastric cancer by correlating it with the histopathologic features of the tumors. Fifty patients with locally advanced gastric adenocarcinoma who were referred for preoperative FDG-PET/CT scans were enrolled in this study. The detection rate of PET/CT and maximum standardized uptake values (SUV{sub max}) of the primary tumor were compared using the WHO, Lauren, Ming and Borrmann classifications and tumor size and location. In 45 of the 50 patients (90 %), the primary gastric tumors were detected by FDG PET/CT. On comparison using the WHO classification, the detection rate and SUV{sub max} of the tubular type were significantly higher than those of the poorly cohesive type. On comparison using the Lauren and Ming classifications, the SUV{sub maxs} of the intestinal type and expanding type were significantly higher than those of the diffuse and infiltrative type, respectively. On comparison using the Borrmann classification and tumor size and location, there was no significant difference in the detection rate and SUV{sub max} of primary gastric tumors. This study demonstrates that the poorly cohesive type according to the WHO classification, diffuse type according to the Lauren classification and infiltrative type according to the Ming classification have low FDG uptake in patients with locally advanced gastric carcinoma. Understanding the relationship between primary tumor FDG uptake and histopathologic features would be helpful in detecting the primary tumor by FDG PET/CT in patients with gastric cancer.

  5. Evaluation of anesthesia effects on [{sup 18}F]FDG uptake in mouse brain and heart using small animal PET

    Energy Technology Data Exchange (ETDEWEB)

    Toyama, Hiroshi E-mail: htoyama@fujita-hu.ac.jp; Ichise, Masanori; Liow, Jeih-San; Vines, Douglass C.; Seneca, Nicholas M.; Modell, Kendra J.; Seidel, Jurgen; Green, Michael V.; Innis, Robert B

    2004-02-01

    This study evaluates effects of anesthesia on {sup 18}F-FDG (FDG) uptake in mouse brain and heart to establish the basic conditions of small animal PET imaging. Prior to FDG injection, 12 mice were anesthetized with isoflurane gas; 11 mice were anesthetized with an intraperitoneal injection of a ketamine/xylazine mixture; and 11 mice were awake. In isoflurane and ketamine/xylazine conditions, FDG brain uptake (%ID/g) was significantly lower than in controls. Conversely, in the isoflurane condition, %ID/g in heart was significantly higher than in controls, whereas heart uptake in ketamine/xylazine mice was significantly lower. Results suggest that anesthesia impedes FDG uptake in mouse brain and affects FDG uptake in heart; however, the effects in the brain and heart differ depending on the type of anesthesia used.

  6. FDG-PET/CT for Monitoring Response of Melanoma to the Novel Oncolytic Viral Therapy Talimogene Laherparepvec.

    Science.gov (United States)

    Covington, Matthew F; Curiel, Clara N; Lattimore, Lois; Avery, Ryan J; Kuo, Phillip H

    2017-02-01

    61-year-old woman with stage IIIa (T3a N1a M0) left lower leg melanoma with lesions suggestive of in-transit metastases 8 months following wide local excision and femoral nodal dissection. FDG-PET/CT demonstrated 5 FDG-avid in-transit nodal metastases in the distal left leg, confirmed on biopsy. Talimogene laherparepvec (T-VEC) oncolytic immunotherapy consisting of intralesional injections of modified herpes simplex virus-expressing granulocyte-macrophage colony-stimulating factor was completed over 6 months. Subsequent FDG-PET/CT demonstrated reduced or resolved FDG activity in the treated in-transit metastases and a new FDG-avid left thigh in-transit metastasis. FDG-PET/CT can monitor response to T-VEC and potentially other novel viral immunotherapies.

  7. Global polarization measurement in Au+Au collisions

    Energy Technology Data Exchange (ETDEWEB)

    Abelev, B.I.; Adams, J.; Aggarwal, M.M.; Ahammed, Z.; Amonett,J.; Anderson, B.D.; Anderson, M.; Arkhipkin, D.; Averichev, G.S.; Bai,Y.; Balewski, J.; Barannikova, O.; Barnby, L.S.; Baudot, J.; Bekele, S.; Belaga, V.V.; Bellingeri-Laurikainen, A.; Bellwied, R.; Benedosso, F.; Bhardwaj, S.; Bhasin, A.; Bhati, A.K.; Bichsel, H.; Bielcik, J.; Bielcikova, J.; Bland, L.C.; Blyth, S.-L.; Bonner, B.E.; Botje, M.; Bouchet, J.; Brandin, A.V.; Bravar, A.; Bystersky, M.; Cadman, R.V.; Cai,X.Z.; Caines, H.; Calderon de la Barca Sanchez, M.; Castillo, J.; Catu,O.; Cebra, D.; Chajecki, Z.; Chaloupka, P.; Chattopadhyay, S.; Chen,H.F.; Chen, J.H.; Cheng, J.; Cherney, M.; Chikanian, A.; Christie, W.; Coffin, J.P.; Cormier, T.M.; Cosentino, M.R.; Cramer, J.G.; Crawford,H.J.; Das, D.; Das, S.; Daugherity, M.; de Moura, M.M.; Dedovich, T.G.; DePhillips, M.; Derevschikov, A.A.; Didenko, L.; Dietel, T.; Djawotho,P.; Dogra, S.M.; Dong, W.J.; Dong, X.; Draper, J.E.; Du, F.; Dunin, V.B.; Dunlop, J.C.; Dutta Mazumdar, M.R.; Eckardt, V.; Edwards, W.R.; Efimov,L.G.; Emelianov, V.; Engelage, J.; Eppley, G.; Erazmus, B.; Estienne, M.; Fachini, P.; Fatemi, R.; Fedorisin, J.; Filimonov, K.; Filip, P.; Finch,E.; Fine, V.; Fisyak, Y.; Fu, J.; Gagliardi, C.A.; Gaillard, L.; Ganti,M.S.; Ghazikhanian, V.; Ghosh, P.; Gonzalez, J.S.; Gorbunov, Y.G.; Gos,H.; Grebenyuk, O.; Grosnick, D.; Guertin, S.M.; Guimaraes, K.S.F.F.; Guo,Y.; Gupta, N.; Gutierrez, T.D.; Haag, B.; Hallman, T.J.; Hamed, A.; Harris, J.W.; He, W.; Heinz, M.; Henry, T.W.; Hepplemann, S.; Hippolyte,B.; Hirsch, A.; Hjort, E.; Hoffman, A.M.; Hoffmann, G.W.; Horner, M.J.; Huang, H.Z.; Huang, S.L.; Hughes, E.W.; Humanic, T.J.; Igo, G.; Jacobs,P.; Jacobs, W.W.; Jakl, P.; Jia, F.; Jiang, H.; Jones, P.G.; Judd, E.G.; Kabana, S.; Kang, K.; Kapitan, J.; Kaplan, M.; Keane, D.; Kechechyan, A.; Khodyrev,V.Yu.; Kim, B.C.; Kiryluk, J.; Kisiel, A.; Kislov, E.M.; Klein,S.R.; Kocoloski, A.; Koetke, D.D.; et al.

    2007-08-02

    The system created in non-central relativisticnucleus-nucleus collisions possesses large orbital angular momentum. Dueto spin-orbit coupling, particles produced in such a system could becomeglobally polarized along the direction of the system angular momentum. Wepresent the results of Lambda and anti-Lambda hyperon global polarizationmeasurements in Au+Au collisions at sqrt sNN=62.4 GeV and 200 GeVperformed with the STAR detector at RHIC. The observed globalpolarization of Lambda and anti-Lambda hyperons in the STAR acceptance isconsistent with zero within the precision of the measurements. Theobtained upper limit, lbar P Lambda, anti-Lambda rbar<= 0.02, iscompared to the theoretical values discussed recently in theliterature.

  8. A clinical positron emission tomography facility. 2-{sup 18}FDG studies: Development and results

    Energy Technology Data Exchange (ETDEWEB)

    Ohlsson, Tomas

    1996-10-01

    Two different types of accelerators have been used for production of ({sup 18}F)fluoride, and the isotope produced has been used for radiolabelling of 2-fluoro-2-deoxy-D-glucose (2-{sup 18}FDG). A rotating PET scanner, based on two scintillation camera heads, has been developed and used for human 2-{sup 18}FDG studies. The suitability of an energy window in the Compton region for imaging 511 keV photons in scintillation camera systems has been evaluated. A new simplified method for normalizing clinical 2-{sup 18}FDG results has been developed and validated, using erythrocytes as a reference tissue, requiring only one blood sample in the middle of the PET scan to calculate the integrated 2-{sup 18}FDG input function with an accuracy better than 8 percent. An investigation using 2-{sup 18}FDG PET to monitor the effect of therapy in advanced head and neck cancer patients has been performed. We found that low initial metabolic rate of glucose (MRG) predicted a complete local response. The second PET examination gave no further information for this group. In the group of primary tumours and lymph node metastases representing a combination of high initial MRG and small decrease in MRG at he second PET examination, the outcome was unfavourable. An accurate normalization of 2-{sup 18}FDG uptake was essential to evaluate the results of this study. 239 refs, 10 tabs.

  9. Clinical role of early dynamic FDG-PET/CT for the evaluation of renal cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Reiko; Abe, Koichiro; Sakai, Shuji [Tokyo Women' s Medical University, Department of Diagnostic Imaging and Nuclear Medicine, Tokyo (Japan); Kondo, Tsunenori; Tanabe, Kazunari [Tokyo Women' s Medical University, Department of Urology, Tokyo (Japan)

    2016-06-15

    We studied the usefulness of early dynamic (ED) and whole-body (WB) FDG-PET/CT for the evaluation of renal cell carcinoma (RCC). One hundred patients with 107 tumours underwent kidney ED and WB FDG-PET/CT. We visually and semiquantitatively evaluated the FDG accumulation in RCCs in the ED and WB phases, and compared the accumulation values with regard to histological type (clear cell carcinoma [CCC] vs. non-clear cell carcinoma [N-CCC]), the TNM stage (high stage [3-4] vs. low stage [1-2]), the Fuhrman grade (high grade [3-4] vs. low grade [1-2]) and presence versus absence of venous (V) and lymphatic (Ly) invasion. In the ED phase, visual evaluation revealed no significant differences in FDG accumulation in terms of each item. However, the maximum standardized uptake value and tumour-to-normal tissue ratios were significantly higher in the CCCs compared to the N-CCCs (p < 0.001). In the WB phase, in contrast, significantly higher FDG accumulation (p < 0.001) was found in RCCs with a higher TNM stage, higher Furman grade, and the presence of V and Ly invasion in both the visual and the semiquantitative evaluations. ED and WB FDG-PET/CT is a useful tool for the evaluation of RCCs. (orig.)

  10. Evaluation of acetazolamine response in patients with cerebellar ataxia using dynamic quantitative F-18-FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Y. K.; Lee, D. S.; Lee, J. S.; Kim, M. H.; Lee, K. M.; Yeo, J. S.; Chung, J. K.; Lee, M. C. [College of Medicine, Seoul National Univ., Seoul (Korea, Republic of)

    2001-07-01

    Cerebellar Ataxia (CA) usually shows dramatic response to acetazolamide treatment. But few cases of acetazolamide unresponse CA were reported recently. Using dynamic FDG PET, we tried to evaluate the metabolic abnormality and its drug response in CA. Quantitative F-18-FDG PET was performed prior and after treatment of acetazolamide (250 mg qid for 10 days) in two patient suspected episodic cerebellar ataxia. Using Model-based clustering method, the regional cerebral glucose metabolic rate (rCMRglu) was calculated. Two patients showed different treatment response to acetazolamide. In one patient who showed markedly reduced frequency of the ataxic attack after treatment. FDG PET showed that mean cerebellar glucose metabolism was increased after treatment ({delta}rCMRglu:9%). However, in the other who showed poor response to acetazolamide, FDG PET showed the more decrease metabolism in cerebellar metabolism after treatment ({delta}rCMRglu:-17%). The change of the cerebellar glucose metabolism on FDG PET reflected the symptomatic improvement after acetazolamide in these two CA patients. We could expected that FDG PET might be a very useful tool to quantitatively predict the treatment response in CA and other neurologic disorder.

  11. Characteristics of Integrated 18F-FDG PET/CT in Pulmonary Cryptococcosis

    Energy Technology Data Exchange (ETDEWEB)

    Chung-Jen Huang; Li-Han Hsu (Div. of Pulmonary and Intensive Care Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China)); Dong-Ling You; Pei-Ing Lee (Dept. of Nuclear Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China)); Chia-Chuan Liu; Chih-Shiun Shih (Div. of Thoracic Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China)); Chiang-Ching Shih; Hsiu-Chin Tseng (Dept. of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan (China))

    2009-05-15

    Background: Pulmonary cryptococcosis is an uncommon cause of pulmonary nodules found by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans. It is rarely reported but may mislead interpretation. Purpose: To describe the 18F-FDG PET/CT findings of pulmonary cryptococcosis. Material and Methods: The 18F-FDG PET/CT images of seven patients with pulmonary cryptococcosis were evaluated. Results: The 18F-FDG PET/CT exams showed single or multiple nodular lesions. The standardized uptake values (SUV) in early images varied significantly for the seven patients (ranging from 2.2 to 11.6). Delayed SUVs showed significant increases in four patients. Conclusion: Pulmonary cryptococcosis mimics primary or metastatic lung cancer on 18F-FDG PET/CT scan. Tissue confirmation should be considered for any suspicious pulmonary nodules found on 18F-FDG PET/CT scan with an SUV score higher than 2.5, in order to avoid overdiagnosis or overstaging.

  12. A prospective randomized comparison of testicular functions, sexual functions and quality of life following laparoscopic totally extra-peritoneal (TEP) and trans-abdominal pre-peritoneal (TAPP) inguinal hernia repairs.

    Science.gov (United States)

    Bansal, Virinder Kumar; Krishna, Asuri; Manek, Pratik; Kumar, Subodh; Prajapati, Omprakash; Subramaniam, Rajeshwari; Kumar, Anand; Kumar, Atin; Sagar, Rajesh; Misra, M C

    2017-03-01

    There is very scant literature on the impact of inguinal hernia mesh repair on testicular functions and sexual functions following open and laparoscopic repair. The present randomized study compares TAPP and TEP repairs in terms of testicular functions, sexual functions, quality of life and chronic groin pain. This study was conducted from April 2012 to October 2014. A total of 160 patients with uncomplicated groin hernia were randomized to either trans-abdominal pre-peritoneal (TAPP) repair or totally extra-peritoneal (TEP) repair. Testicular functions were assessed by measuring testicular volume, testicular hormone levels preoperatively and at 3 months postoperatively. Sexual functions were assessed using BMSFI, and quality of life was assessed using WHO-QOL BREF scale preoperatively and at 3 and 6 months postoperatively. Chronic groin pain was evaluated using the VAS scale at 3 months, 6 months and at 1 year. The median duration of follow-up was 13 months (range 6-18 months). The mean preoperative pain scores (p value 0.35) as well as the chronic groin pain were similar between TEP and TAPP repairs at 3 months (p value 0.06) and 6 months (p value 0.86). The testicular resistive index and testicular volume did not show any significant change at follow-up of 3 months (p value 0.9) in the study population. No significant difference was observed in testicular resistive index and testicular volume when comparing TEP and TAPP groups at at follow-up of 3 months (p value >0.05). There was a statistically significant improvement in the sexual drive score, erectile function and overall satisfaction over the follow-up period following laparoscopic inguinal hernia repair. However, sexual function improvement was similar in patients undergoing both TEP and TAPP repairs. All the domains of quality of life in the study population showed a significant improvement at a follow-up of 3 and 6 months. Subgroup analysis of all the domains of quality of life in both TAPP

  13. Arterial and fat tissue inflammation are highly correlated: a prospective {sup 18}F-FDG PET/CT study

    Energy Technology Data Exchange (ETDEWEB)

    Bucerius, Jan [Mount Sinai School of Medicine, Translational and Molecular Imaging Institute, One Gustave L. Levy Place, P. O. Box 1234, New York, NY (United States); Mount Sinai School of Medicine, Department of Radiology, New York, NY (United States); Maastricht University Medical Center, Department of Nuclear Medicine, Maastricht (Netherlands); Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), Maastricht (Netherlands); University Hospital RWTH Aachen, Department of Nuclear Medicine, Aachen (Germany); Mani, Venkatesh; Fayad, Zahi A. [Mount Sinai School of Medicine, Translational and Molecular Imaging Institute, One Gustave L. Levy Place, P. O. Box 1234, New York, NY (United States); Mount Sinai School of Medicine, Department of Radiology, New York, NY (United States); Mount Sinai School of Medicine, Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute and Marie-Josee and Henry R. Kravis Cardiovascular Health Center, New York, NY (United States); Wong, Stephanie; Moncrieff, Colin; Izquierdo-Garcia, David [Mount Sinai School of Medicine, Translational and Molecular Imaging Institute, One Gustave L. Levy Place, P. O. Box 1234, New York, NY (United States); Mount Sinai School of Medicine, Department of Radiology, New York, NY (United States); Machac, Josef [Mount Sinai School of Medicine, Division of Nuclear Medicine, Department of Radiology, New York, NY (United States); Fuster, Valentin [Mount Sinai School of Medicine, Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute and Marie-Josee and Henry R. Kravis Cardiovascular Health Center, New York, NY (United States); The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid (Spain); Farkouh, Michael E. [Mount Sinai School of Medicine, Department of Cardiology, Zena and Michael A. Weiner Cardiovascular Institute and Marie-Josee and Henry R. Kravis Cardiovascular Health Center, New York, NY (United States); Mount Sinai School of Medicine, Cardiovascular Imaging Clinical Trials Unit, New York, NY (United States); Rudd, James H.F. [University of Cambridge, Division of Cardiovascular Medicine, Cambridge (United Kingdom)

    2014-05-15

    There is evidence that the link between obesity and cardiovascular disease might relate to inflammation in both fat tissue and the arterial wall. {sup 18}F-FDG uptake on PET is a surrogate marker of vessel wall inflammation. The aim of the study was to measure FDG uptake in both regions using PET and identify links between adipose and arterial inflammation. Included in the study were 173 cardiovascular patients who were prospectively imaged with FDG PET/CT. Arterial FDG uptake was measured in the carotid arteries and ascending aorta. The same was done in fat tissue in the neck, the presternal region (both subcutaneous) and the pericardium. FDG uptake was quantified as average maximal target-to-background ratio ({sub mean}TBR{sub max}). Multivariate regression analyses were performed to identify significant associations between arterial and adipose tissue FDG uptake and clinical variables as given by the standardized correlation coefficient (β). FDG uptake values in all fat tissue regions were highly predictive of vascular FDG uptake in both the carotids (β 0.262, p < 0.0001, in the neck subcutaneous region) and aorta (β 0.22, p = 0.008, in the chest pericardial region; β 0.193, p = 0.019, in the chest subcutaneous region). Obesity was significantly associated with elevated FDG uptake in adipose tissue (β 0.470, p < 0.0001, in the neck subcutaneous region; β 0.619, p = 0.028, in the chest subcutaneous region; β 0.978, p = 0.035, in the chest pericardial region). FDG uptake in diverse fat tissue regions was significantly associated with arterial FDG uptake, a reasonable surrogate of inflammation. Increasing body weight significantly predicted the level of fatty inflammation. FDG PET therefore provides imaging evidence of an inflammatory link between fat tissue and the vasculature in patients with cardiovascular disease. (orig.)

  14. A comparison study of esophageal findings on {sup 18}F-FDG PET/CT and esophagogastroduodenoscopy

    Energy Technology Data Exchange (ETDEWEB)

    Jo, Kwan Hyeong; Kim, So Young; Cha, Jong Tae; Hwang, Sang Hyun; Lee, Narae; Yun, Mi Jin; Kang, Won Jun [Dept. of Nuclear Medicine, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2016-06-15

    The aim of this study was to compare the esophageal findings of 2-deoxy-2-[{sup 18}F]fluoro-d-glucose positron emission tomography-computed tomography ({sup 18}F-FDG PET/CT) and esophagogastroduodenoscopy (EGD). We retrospectively reviewed {sup 18}F-FDG PET/CT and EGD findings of 369 subjects who underwent medical examination between January 2014 and December 2014. The range and intensity of esophageal {sup 18}F-FDG uptake were visually analyzed. The maximum standardized uptake value (SUV{sub max}) of the esophagus and around the esophagogastric (EG) junction was measured. EGD results were provided by the gastroenterologist. We compared the esophageal findings obtained using {sup 18}F-FDG PET/CT and EGD. There were typical linear FDG uptakes in {sup 18}F-FDG PET/CT patients who underwent EGD the same day. In visual analysis of the range and intensity of the {sup 18}F-FDG uptake, the patients who underwent {sup 18}F-FDG PET/CT and EGD on the same day showed relatively diffuse and discernible {sup 18}F-FDG uptake in the esophagus. Reflux esophagitis was diagnosed in 59 subjects, and 27 of these were classified as higher than Los Angeles classification A. With an increasing degree of reflux esophagitis observed on EGD, the SUV{sub max} in the esophagus and around the EG junction was also increased. Our study showed that FDG uptake at the esophagus or the EG junction might be clinically significantly related to esophagitis. However, EGD performed before {sup 18}F-FDG PET/CT on the same day may affect the esophageal {sup 18}F-FDG uptake.

  15. Detection of unsuspected myocardial ishemia during F-18 FDG PET in the evaluation of a solitary pulmonary nodule

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chan H.; Park, Kwang J.; Lee, Myoung Hoon [College of Medicine, Ajou Univ., Suwon (Korea, Republic of)

    2001-07-01

    Enhanced F-18 FDG uptake at rest after an overnight fast occurs in myocardial ischemia and is associated with functional improvement after PTCA or CABG. For more pronounced regional differences of FDG uptake in the fasting state occur, the detection of dysfunctional myocardium during oncologic application of FDG PET has not been productive. A case of unsuspected myocardial ischemia indicated by focal FDG uptake during camera based (CB) FDG PET in the evaluation of a solitary pulmonary nodule is described. A 58-year-old male patient was admitted to the hospital for the evaluation of a solitary pulmonary nodule (SPN) measuring 1.7 cm in diameter in the right upper lobe. CB FDG PET for diagnosis of lung cancer and staging depicted lung cancer without nodal involvement but there was increased FDG uptake in the region of inferior wall of LV. CB FDG PET without attenuation correction always depicts decreased FDG uptake in the inferior wall when LV is visualized. Therefore, only FDG uptake in inferior wall in this case was indicative of myocardial ischemia and next day stress Tl-201 myocardial SPECT was performed. This demonstrated inferior wall ischemia which was confirmed by coronary angiogram. Then he underwent PTCA for 80% stenosis of mid RCA and right ventricular branch followed by right upper lobectomy one month after the PTCA. In conclusion, a rare finding of enhanced myocardial uptake of F-18 FDG at rest during CD FDG PET for SPN was associated with myocardial ischemia. Clinically unsuspected myocardial ischemia was treated successfully by PTCA before lobectomy for NSCLC for the patient.

  16. Current role of FDG PET/CT in lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Kostakoglu, Lale [Icahn School of Medicine at Mount Sinai, Department of Radiology, One Gustave Levy Place, Box 1141, New York, NY (United States); Cheson, Bruce D. [Georgetown University Hospital, Division of Hematology-Oncology, Lombardi Comprehensive Cancer Center, Washington, DC (United States)

    2014-05-15

    The management approach in Hodgkin's (HL) and high-grade non-Hodgkin's lymphomas (NHL) has shifted towards reducing the toxicity and long-term adverse effects associated with treatment while maintaining favorable outcomes in low-risk patients. The success of an individualized treatment strategy depends largely on accurate diagnostic tests both at staging and during therapy. In this regard, positron emission tomography (PET) using fluorodeoxyglucose (FDG) with computed tomography (CT) has proved effective as a metabolic imaging tool with compelling evidence supporting its superiority over conventional modalities, particularly in staging and early evaluation of response. Eventually, this modality was integrated into the routine staging and restaging algorithm of lymphomas. This review will summarize the data on the proven and potential utility of PET/CT imaging for staging, response assessment, and restaging, describing current limitations of this imaging modality. (orig.)

  17. Repeatability of quantitative FDG-PET/CT and contrast-enhanced CT in recurrent ovarian carcinoma: test-retest measurements for tumor FDG uptake, diameter, and volume.

    Science.gov (United States)

    Rockall, Andrea G; Avril, Norbert; Lam, Raymond; Iannone, Robert; Mozley, P David; Parkinson, Christine; Bergstrom, Donald; Sala, Evis; Sarker, Shah-Jalal; McNeish, Iain A; Brenton, James D

    2014-05-15

    Repeatability of baseline FDG-PET/CT measurements has not been tested in ovarian cancer. This dual-center, prospective study assessed variation in tumor 2[18F]fluoro-2-deoxy-D-glucose (FDG) uptake, tumor diameter, and tumor volume from sequential FDG-PET/CT and contrast-enhanced computed tomography (CECT) in patients with recurrent platinum-sensitive ovarian cancer. Patients underwent two pretreatment baseline FDG-PET/CT (n = 21) and CECT (n = 20) at two clinical sites with different PET/CT instruments. Patients were included if they had at least one target lesion in the abdomen with a standardized uptake value (SUV) maximum (SUVmax) of ≥ 2.5 and a long axis diameter of ≥ 15 mm. Two independent reading methods were used to evaluate repeatability of tumor diameter and SUV uptake: on site and at an imaging clinical research organization (CRO). Tumor volume reads were only performed by CRO. In each reading set, target lesions were independently measured on sequential imaging. Median time between FDG-PET/CT was two days (range 1-7). For site reads, concordance correlation coefficients (CCC) for SUVmean, SUVmax, and tumor diameter were 0.95, 0.94, and 0.99, respectively. Repeatability coefficients were 16.3%, 17.3%, and 8.8% for SUVmean, SUVmax, and tumor diameter, respectively. Similar results were observed for CRO reads. Tumor volume CCC was 0.99 with a repeatability coefficient of 28.1%. There was excellent test-retest repeatability for FDG-PET/CT quantitative measurements across two sites and two independent reading methods. Cutoff values for determining change in SUVmean, SUVmax, and tumor volume establish limits to determine metabolic and/or volumetric response to treatment in platinum-sensitive relapsed ovarian cancer. ©2014 American Association for Cancer Research.

  18. Quality control of [{sup 18}F]FDG injection. Bacterial endotoxin test, aluminum ions test and HPLC analysis for FDG and CIDG

    Energy Technology Data Exchange (ETDEWEB)

    Nakao, R.; Suzuki, K. [National Institute of Radiological Sciences, Chiba (Japan). Dept. of Medical Imaging; Kida, T. [National Institute of Radiological Sciences, Chiba (Japan). Dept. of Medical Imaging; Sumitomo Accelerator Service, Tokyo (Japan)

    2004-07-01

    Quality control of 2-deoxy-2-[{sup 18}F]fluoro-D-glucose ([{sup 18}F]FDG) preparations for injection, the most commonly used radiopharmaceutical for positron emission tomography (PET), has recently received much attention due to its increasingly widespread use in clinical studies. In the USP and EP tests for specific radioactivity, bacterial endotoxin and chemical impurities such as 2-deoxy-2-chloro-D-glucose (ClDG) have been listed, and maximum permissible levels have been proposed. In Japan, in addition to these tests, the aluminum ions test is also mandatory. A number of methods have been developed for manufacturing [{sup 18}F]FDG and many automated devices for its manufacture are available commercially. The composition of the manufactured [{sup 18}F]FDG varies depending on the method and the device used for the manufacture. However, the constituents often influence the results of the endotoxin test and aluminum ions test. In this context, high-performance anion exchange chromatography coupled with pulsed amperometric detector (HPAEC/PAD) has been described in the USP and EP as the method to be used for the determination of FDG and ClDG. However, we have often observed when using HPAEC/PAD to measure reference ClDG samples, that the sensitivity varies from measurement to measurement and differs markedly depending on the ambient temperature in the laboratory. In the present study, we examined the effects of the constituents of [{sup 18}F]FDG preparations for injection manufactured using various commercially available equipments on the results of the endotoxin test and aluminum ions test, as well as the effects of the HAPEC/PAD column temperature on the determination of FDG and ClDG. (orig.)

  19. d + Au hadron correlation measurements at PHENIX

    Energy Technology Data Exchange (ETDEWEB)

    Sickles, Anne M., E-mail: anne@bnl.gov

    2014-06-15

    In these proceedings, we discuss recent results from d + Au collisions in PHENIX ridge related measurements and their possible hydrodynamic origin. We present the v{sub 2} at midrapidity and measurements of the pseudorapidity dependence of the ridge, distinguishing between the d-going and Au-going directions. We investigate the possible geometrical origin by comparing v{sub 2} in d + Au to that in p + Pb, Au + Au and Pb + Pb collisions. Future plans to clarify the role of geometry in small collision systems at RHIC are discussed.

  20. Microvessel Density But Not Neoangiogenesis Is Associated with (18)F-FDG Uptake in Human Atherosclerotic Carotid Plaques

    DEFF Research Database (Denmark)

    Pedersen, Sune Folke; Græbe, Martin; Hag, Anne Mette Fisker

    2011-01-01

    endothelial growth factor (VEGF) and integrin aV and integrin ß3 subunits, genes essential during neoangiogenesis. We also evaluated the gene expression of CD34, a measure of microvessel density (MVD), as well as CD68, MMP-9, and cathepsin K, genes of major importance in plaque vulnerability. Gene expression...... analysis was compared with 18FDG-PET. Results: VEGF and integrin aVß3 gene expression did not correlate with 18FDG uptake, whereas CD34 gene expression exhibited an inverse correlation with 18FDG uptake. Additionally, we established that markers of vulnerability were correlated with 18FDG uptake...

  1. Clinical impact of FDG-PET/CT in the planning of radiotherapy for early-stage Hodgkin lymphoma

    DEFF Research Database (Denmark)

    Hutchings, Martin; Loft, Annika; Hansen, Mads

    2007-01-01

    of 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computerised tomogrpahy (FDG-PET/CT) in the planning of involved field radiotherapy (IFRT). PATIENTS AND METHODS: Thirty patients received staging FDG-PET/CT before therapy, and IFRT after a short course of ABVD (adriamycin, bleomycin......, vinblastine, dacarbazine) chemotherapy. IFRT planning was performed using only the CT data from the FDG-PET/CT scan. Later, the IFRT planning was performed anew using the FDG-PET/CT data as basis for contouring. RESULTS: In 20 out of 30 patients, the radiotherapy (RT) course was unaffected by the addition...

  2. Application of 2-deoxy-2-fluoro-D-glucose (FDG in plant imaging: past, present, and future

    Directory of Open Access Journals (Sweden)

    Amol eFatangare

    2016-05-01

    Full Text Available The aim of this review article is to explore and establish the current status of 2-deoxy-2-fluoro-D-glucose (FDG applications in plant imaging. In present article, we review all the previous literature on its experimental merits to formulate a consistent and inclusive picture of FDG applications in plant imaging research.FDG is a [18F]fluorine labeled glucose analog in which C-2 hydroxyl group has been replaced by positron emitting [18F] radioisotope. FDG being a positron emitting radiotracer could allow for in vivo imaging. FDG mimics glucose chemically and structurally. Its uptake and distribution is found to be similar to that of glucose in animal models. FDG is commonly used as a radiotracer for glucose in medical diagnostics and in vivo animal imaging studies but rarely in plant imaging. Tsuji et al (2002 first reported FDG uptake and distribution in tomato plants. Later, Hattori et al (2008 described FDG translocation in intact sorghum plants and suggested that it could be used as a tracer for photoassimilate translocation in plants. These findings raised interest among other plant scientists which resulted in recent surge of research papers involving FDG as a tracer in plants. In total, there have been 7 studies describing FDG imaging applications in plants. These studies describe FDG applications ranging from monitoring radiotracer translocation to analyzing solute transport, root uptake, photoassimilates tracing, carbon allocation, or glycoside biosynthesis. Recently, Fatangare et al (2015 characterized FDG metabolism in plants which was a crucial aspect of understanding and validating FDG applications in plant research. Although all of the above studies significantly advanced our understanding of FDG translocation and metabolism in plants, it also raised new questions. Here, we take a look at the previous results cumulatively to form a comprehensive picture of FDG translocation, metabolism, and applications in plants.In conclusion, we

  3. How to differentiate benign versus malignant cardiac and paracardiac 18F FDG uptake at oncologic PET/CT.

    Science.gov (United States)

    Maurer, Alan H; Burshteyn, Mark; Adler, Lee P; Steiner, Robert M

    2011-01-01

    Patients undergoing 2-[fluorine 18]fluoro-2-deoxy-d-glucose (FDG) whole-body oncologic positron emission tomography (PET)/computed tomography (CT) are studied while fasting. Cardiac FDG uptake in fasted patients has been widely reported as variable. It is important to understand the normal patterns of cardiac FDG activity that can be seen in oncologic FDG PET/CT studies. These include focal and regional patterns of increased FDG myocardial activity. Focal activity can be observed in papillary muscles, the atria, the base, and the distal anteroapical region of the left ventricle. Regional increased cardiac FDG activity may be diffuse or localized in the posterolateral wall or the base of the left ventricle. Abnormal patterns of cardiac FDG activity not related to malignancy include those associated with lipomatous hypertrophy of the interatrial septum, epicardial and pericardial fat, increased atrial activity associated with atrial fibrillation or a prominent crista terminalis, cardiac sarcoidosis, endocarditis, myocarditis, and pericarditis. Knowledge of these patterns of cardiac FDG activity is important to be able to recognize malignant disease involving the paracardiac spaces, myocardium, and pericardium. With a better understanding of the range of normal and abnormal patterns of cardiac FDG activity, important benign and malignant diseases involving the heart and pericardium can be recognized and diagnosed.

  4. Performance profile of a FDG-PET cancer screening program for detecting gastric cancer: results from a nationwide Japanese survey.

    Science.gov (United States)

    Minamimoto, Ryogo; Senda, Michio; Jinnouchi, Seishi; Terauchi, Takashi; Yoshida, Tsuyoshi; Inoue, Tomio

    2014-05-01

    It has been reported that gastric cancer is the sixth most common cancer found during the (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) cancer screening program, which is defined as cancer screening of asymptomatic subjects using FDG-PET(/CT) (in combination with other screening tests or not). The aim of this study was to analyze the detection rate and the effectiveness of the FDG-PET cancer screening program at detecting gastric cancer between 2006 and 2009 in Japan. A total of 153,775 asymptomatic subjects (92,255 men, 61,520 women) between 30 and 80 years old underwent the FDG-PET cancer screening program. Of these, we analyzed 790 cases with findings of possible gastric cancer in any screening test. The number of cases who were verified to have gastric cancer was 124. Among these, only 47 cases were detected by FDG-PET, which resulted in a relative sensitivity of 37.9% and a positive predictive value of 33.6%. The relative sensitivity of FDG-PET was much lower than those of gastric endoscopy and the serum pepsinogen test. The FDG-PET screening program in Japan detected some cases of early-stage gastric cancer, but this was not achieved using FDG-PET alone but in combination with gastric endoscopy. Gastric endoscopy should be included in FDG-PET cancer screening programs to screen for gastric cancer.

  5. Modification of staging and treatment of head and neck cancer by FDG-PET/CT prior to radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Abramyuk, A. [OncoRay - National Center for Radiation Research in Oncology, Biological and Molecular Imaging and University Hospital Dresden (Germany); University Hospital Dresden (Germany). Dept. of Neuroradiology; Appold, S. [University Hospital Dresden (Germany). Dept. of Radiation Oncology; Zoephel, K. [University Hospital Dresden (Germany). Clinic and Policlinic for Nuclear Medicine; Baumann, M. [OncoRay - National Center for Radiation Research in Oncology, Biological and Molecular Imaging and University Hospital Dresden (Germany); University Hospital Dresden (Germany). Dept. of Radiation Oncology; Abolmaali, N. [OncoRay - National Center for Radiation Research in Oncology, Biological and Molecular Imaging and University Hospital Dresden (Germany); University Hospital Dresden (Germany). Inst. and Policlinic of Diagnostic Radiology

    2013-03-15

    Background and purpose: Reliable tumor staging is a fundamental pre-requisite for efficient tumor therapy and further prognosis. The aim of this study was to compare head and neck cancer (HNC) staging before and after FDG-PET/CT, evaluating the stage modifications for radiotherapy (RT) planning. Patients and methods: A total of 102 patients with untreated primary HNC, who underwent conventional staging and staging including FDG-PET/CT before RT, were enrolled in this retrospective study. Blinded pre-FDG-PET/CT and post-FDG-PET/CT staging data were compared. The impact on patient management was tested by comparing the intention before and after FDG-PET/CT. Results: Significant modifications of T, N, and M stage as well as clinical stage were detected after inclusion of FDG-PET/CT data (p = 0.002, 0.0006, 0.001, 0.03, respectively). Overall, the implementation of FDG-PET/CT led to modification of RT intention decision in 14 patients. Conclusions: FDG-PET/CT demonstrates essential influence on tumor staging in HNC patients scheduled for irradiation. Implementation of FDG-PET/CT in imaging protocol improves selection of candidates for curative and palliative RT and allows further optimization of treatment management and therapy intention. (orig.)

  6. The clinical utility of FDG PET/CT among solid organ transplant recipients suspected of malignancy or infection

    DEFF Research Database (Denmark)

    Wareham, Neval E; Lundgren, J D; Da Cunha-Bang, C

    2017-01-01

    PURPOSE: Solid organ transplant (SOT) recipients are at high risk of developing infections and malignancies. (18)F-FDG PET/CT may enable timely detection of these diseases and help to ensure early intervention. We aimed to describe the clinical utility of FDG PET/CT in consecutive, diagnostic...... unresolved SOT recipients transplanted from January 2004 to May 2015. METHODS: Recipients with a post-transplant FDG PET/CT performed as part of diagnostic work-up were included. Detailed chart reviews were done to extract relevant clinical information and determine the final diagnosis related to the FDG PET...

  7. Decay spectroscopy of $^{178}$Au

    CERN Document Server

    Whitmore, B

    In this thesis, the neutron-deficient nucleus $^{178}$Au is investigated through decay spectroscopy. Si and HPGe detectors were used to analyse the decay radiation of $^{178}$Au and its daughter nuclei. Previous studies have been unable to distinguish decay radiation from different isomeric states of this nucleus. This thesis represents the first time such isomeric discrimination has been achieved, and presents tentative spin assignments of both the ground state and an isomer. The neutron-deficient gold isotopes are an area of interest for the study of shape coexistence. This is the phenomenon exhibited by nuclei able to exist at a number of close lying energy minima, each reflecting a distinct type of deformation. It is hoped that studies such as this can help identify the evolution of nuclear deformation in this region of the nuclear chart.

  8. Le CRDI au Costa Rica

    International Development Research Centre (IDRC) Digital Library (Canada)

    La stabilité politique du Costa Rica a fait de ce pays un partenaire essen- tiel du CRDI en Amérique centrale pour la recherche portant sur l'agriculture, les politiques économiques, la démocratisation et la prévention des catastrophes naturelles. Le CRDI a beaucoup contribué à la recherche en agriculture au Costa Rica,.

  9. Cas de Cotonou au Benin

    African Journals Online (AJOL)

    Au nombre de ces nuisances, figurent entre autres, la perte de temps et par ricochet d'importantes recettes .... La méthodologie utilisée est basée sur deux types d'approches : l'approche théorique et celle empirique. Le premier volet de ...... Université de Bordeaux Talence, 456 pages. SEGBEDJI, E. (2001) : Impact du trafic ...

  10. Association between {sup 18}F-FDG avidity and the BRAF mutation in papillary thyroid carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Suk Hyun; Han, Sang Won; Lee, Hyo Sang; Chae, Sun Young; Lee, Jong Jin; Song, Dong Eun; Ryu, Jin Sook [Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2016-03-15

    The BRAF mutation, a potential prognostic factor in papillary thyroid carcinoma (PTC), is associated with a high expression of the glucose transporter gene. We investigated which clinicopathologic factors, including BRAF mutation status, influence {sup 18}F-fluoro-2-deoxyglucose ({sup 18}F-FDG) avidity. We retrospectively reviewed 55 patients who underwent BRAF analysis from biopsy-confirmed PTC and {sup 18}F-FDG positron emission tomography/computed tomography within 6 months before undergoing thyroid surgery from September 2008 to August 2014. Tumors were considered to be {sup 18}F-FDG avid if the uptake was greater than that of the liver. {sup 18}F-FDG uptake of PTCs was also analyzed semiquantitatively using SUV{sub max}. The association between {sup 18}F-FDG avidity and clinicopathologic variables (age, tumor size, perithyroidal extension, cervical lymph node status, and BRAF mutation status) was investigated. Twenty-nine (52.7 %) of 55 patients had {sup 18}F-FDG-avid PTCs. PTCs with the BRAF mutation showed higher {sup 18}F-FDG avidity (24/38, 63.2 %) than those without (5/17, 29.4 %). The BRAF mutation (p = 0.025) and tumor size (p = 0.003) were significantly associated with {sup 18}F-FDG avidity in univariate analysis, and the BRAF mutation status remained significant after adjusting for tumor size in multivariate analysis (p = 0.015). In the subgroup of tumor size ≥ 1 cm, the BRAF mutation was the only factor significantly associated with {sup 18}F-FDG avidity (p = 0.021). The mean SUV{sub max} of PTCs with the BRAF mutation was significantly higher than that of those without (4.89 ± 6.12 vs. 1.96 ± 1.10, p = 0.039). The BRAF mutation must be one of the most important factors influencing {sup 18}F-FDG avidity in PTCs, especially in those with a tumor size ≥ 1 cm.

  11. Factors affecting gastric uptake in whole body FDG-PET imaging

    Energy Technology Data Exchange (ETDEWEB)

    Tomemori, Takashi; Kitagawa, Mami; Nakahara, Tadaki; Wu, Jin; Nakagawa, Keiichi; Uno, Kimiichi; Abe, Kinji; Tomiyoshi, Katsumi [Nishidai Clinic Diagnostic Imaging Center, Tokyo (Japan)

    2001-06-01

    Positron emission tomography (PET) using 2-deoxy-2-[{sup 18}F]-fluoro-D-glucose (FDG) is very useful for the detection and staging of tumors. However, FDG is also accumulated in the normal tissues in various degrees. This physiological FDG uptake is often seen in intestine, making confusion with malignant tumor. The aim of this study was to identify factors influencing physiological FDG uptake in the stomach. A total of 136 people who underwent cancer screening or staging of tumors except for gastric cancer using FDG whole-body PET was examined (mean age: 55.6 yrs). All subjects fasted for at least 4 hours before the PET study and were administrated with FDG intravenously (mean FDG dose: 308.9 MBq). Emission images were acquired on a whole-body PET scanner and images were reconstructed without attenuation correction. The intensity of gastric uptake of FDG whole-body PET image was visually classified into 3 grades; grade 2 = the intensity of gastric uptake more than pulmonary uptake, grade 1 = the intensity of gastric uptake equal to or less than pulmonary uptake, grade 0 = no contrast between gastric uptake and background. Twenty-eight subjects (20.6%) were classified into grade 2, 42 subjects (30.9%) were grade 1 and 66 subjects (48.5%) were grade 0. Subjects' age, fasting time, FDG dose, serum glucose level, free fatty acid level and insulin level were not significantly correlated with the intensity of gastric uptake. But the subjects with higher gastric uptake tended to have anti-Helicobactor pylori (H. pylori) antibodies. The rate of having anti-H.pylori antibodies in the grade 2 group is significantly higher than the grade 1 group (85.7% vs. 72.5%, p<0.05), and that of the grade 1 group is significantly higher than the grade 0 group (72.5% vs. 42.2%, p<0.01). Gastric uptake was observed in about half of subjects. Especially, approximately 20% of all showed high gastric uptake, which was associated with H.pylori infection. Therefore, most of the subjects

  12. Defining optimal tracer activities in pediatric oncologic whole-body (18)F-FDG-PET/MRI.

    Science.gov (United States)

    Gatidis, Sergios; Schmidt, Holger; la Fougère, Christian; Nikolaou, Konstantin; Schwenzer, Nina F; Schäfer, Jürgen F

    2016-12-01

    To explore the feasibility of reducing administered tracer activities and to assess optimal activities for combined (18)F-FDG-PET/MRI in pediatric oncology. 30 (18)F-FDG-PET/MRI examinations were performed on 24 patients with known or suspected solid tumors (10 girls, 14 boys, age 12 ± 5.6 [1-18] years; PET scan duration: 4 min per bed position). Low-activity PET images were retrospectively simulated from the originally acquired data sets using randomized undersampling of list mode data. PET data of different simulated administered activities (0.25-2.5 MBq/kg body weight) were reconstructed with or without point spread function (PSF) modeling. Mean and maximum standardized uptake values (SUVmean and SUVmax) as well as SUV variation (SUVvar) were measured in physiologic organs and focal FDG-avid lesions. Detectability of organ structures and of focal (18)F-FDG-avid lesions as well as the occurrence of false-positive PET lesions were assessed at different simulated tracer activities. Subjective image quality steadily declined with decreasing tracer activities. Compared to the originally acquired data sets, mean relative deviations of SUVmean and SUVmax were below 5 % at (18)F-FDG activities of 1.5 MBq/kg or higher. Over 95 % of anatomic structures and all pathologic focal lesions were detectable at 1.5 MBq/kg (18)F-FDG. Detectability of anatomic structures and focal lesions was significantly improved using PSF. No false-positive focal lesions were observed at tracer activities of 1 MBq/kg (18)F-FDG or higher. Administration of (18)F-FDG activities of 1.5 MBq/kg is, thus, feasible without obvious diagnostic shortcomings, which is equivalent to a dose reduction of more than 50 % compared to current recommendations. Significant reduction in administered (18)F-FDG tracer activities is feasible in pediatric oncologic PET/MRI. Appropriate activities of (18)F-FDG or other tracers for specific clinical questions have to be further established in selected

  13. L’apprentissage au CERN

    CERN Multimedia

    Staff Association

    2016-01-01

    En 1961, sur la base du constat que l’évolution du marché du travail nécessitait un besoin croissant de personnel qualifié, le 1er accord entre la République et canton de Genève et le CERN fut signé. Cet accord avait notamment pour objet la formation professionnelle de jeunes électroniciens et techniciens de laboratoires en physique. Le CERN, acteur local économique d’importance, soulignait par cet accord sa volonté de participer au développement économique et social local. Le 1er apprenti arriva au CERN en 1965. En 1971, le centre d’apprentissage fut créé ; il accueille aujourd’hui plus d’une vingtaine d’apprentis au total, à raison d’environ six nouveaux apprentis chaque année. Cet apprentissage est dédié aux jeunes âgés e...

  14. Positron emission tomography: Which indications, which benefits?; Tomographie par emission de positons (TEP): quelles indications, quels benefices?

    Energy Technology Data Exchange (ETDEWEB)

    Chassoux, F. [Ctr Hosp St Anne, Serv Neurochirurg, F-75014 Paris (France); Chassoux, F.; Chiron, C. [CEA, I2BM, Serv Hosp Frederic Joliot, F-91 Orsay (France); Chiron, C. [Hop Necker Enfants Malad, INSERM, U663, F-75015 Paris (France); Chassoux, F.; Chiron, C. [Univ Paris 06, F-75005 Paris (France)

    2008-07-01

    Positron emission tomography (PET) is currently used in the pre-surgical workup for drug-resistant partial epilepsies in addition to MRI. Inter-ictal metabolism is studied in clinical practice using {sup 18}fluoro-desoxy-glucose ({sup 18}FDG). In medial temporal lobe epilepsy (MTLE) associated with hippocampal sclerosis, hypo-metabolism ipsilateral to the epileptogenic focus is found in 70-90% of cases. However, hypo-metabolism is larger than the structural lesion observed on MRI and includes the epileptogenic zone and ictal discharge spread areas. Hypo-metabolism is related to surgical outcome and cognitive disturbances in MTLE. Although the usefulness of PET appears less well-established in extra-temporal lobe epilepsy and in children, its sensitivity may be improved by co-registration and superimposition of PET on MRI at any age. Focal hypo-metabolism can be easily detected by visual analysis, allowing detection of minor gyral abnormalities that may correspond to focal cortical dysplasias. Moreover, in cases of negative MRI, focal hypo-metabolism findings may help invasive monitoring planning and deep electrode placement for SEEG, and finally improve surgical outcome. (authors)

  15. Fabricating a Homogeneously Alloyed AuAg Shell on Au Nanorods to Achieve Strong, Stable, and Tunable Surface Plasmon Resonances

    KAUST Repository

    Huang, Jianfeng

    2015-08-13

    Colloidal metal nanocrystals with strong, stable, and tunable localized surface plasmon resonances (SPRs) can be useful in a corrosive environment for many applications including field-enhanced spectroscopies, plasmon-mediated catalysis, etc. Here, a new synthetic strategy is reported that enables the epitaxial growth of a homogeneously alloyed AuAg shell on Au nanorod seeds, circumventing the phase segregation of Au and Ag encountered in conventional synthesis. The resulting core–shell structured bimetallic nanorods (AuNR@AuAg) have well-mixed Au and Ag atoms in their shell without discernible domains. This degree of mixing allows AuNR@AuAg to combine the high stability of Au with the superior plasmonic activity of Ag, thus outperforming seemingly similar nanostructures with monometallic shells (e.g., Ag-coated Au NRs (AuNR@Ag) and Au-coated Au NRs (AuNR@Au)). AuNR@AuAg is comparable to AuNR@Ag in plasmonic activity, but that it is markedly more stable toward oxidative treatment. Specifically, AuNR@AuAg and AuNR@Ag exhibit similarly strong signals in surface-enhanced Raman spectroscopy that are some 30-fold higher than that of AuNR@Au. When incubated with a H2O2 solution (0.5 m), the plasmonic activity of AuNR@Ag immediately and severely decayed, whereas AuNR@AuAg retained its activity intact. Moreover, the longitudinal SPR frequency of AuNR@AuAg can be tuned throughout the red wavelengths (≈620–690 nm) by controlling the thickness of the AuAg alloy shell. The synthetic strategy is versatile to fabricate AuAg alloyed shells on different shaped Au, with prospects for new possibilities in the synthesis and application of plasmonic nanocrystals.

  16. 探討臺灣學生的自律學習:TEPS 資料的縱貫性分析 Self-Regulation Learning among Taiwanese Students: A Longitudinal Analysis of the TEPS Database

    Directory of Open Access Journals (Sweden)

    趙珮晴 Pei-Ching Chao

    2011-09-01

    Full Text Available 課後學生自主的時間能否自己自律繼續學習,是值得關注的議題。本研究欲瞭解學生從國中到高中自律學習發展情況,以台灣教育長期追蹤資料庫的2,939個追蹤樣本,進行潛在成長曲線模型分析。在本研究的假設模型中發現:兩性學生在自律學習的假設模型無顯著差異,而且國中高自律學習的學生到高中的自律學習成長有限;國中低自律學習的學生到高中自律學習成長幅度較大。至於學生家庭社經地位愈高、父母學校參與和接納的程度愈高,學生國中時期的自律學習情況會愈好;但是學生家庭社經地位愈高、父母學校參與程度愈高,對於學生國中到高中自律學習成長有限,至於父母接納則無顯著影響關係。另外,國中自律學習良好的學生,有較良好的分析能力;但是自律學習無法有效預測分析能力的成長情況。本研究將依據上述研究結果提出相關結論與建議以供參考。 Students self-regulating their learning after school is an important topic. This study examines the development of self-regulation learning (SRL and analytical abilities using 2,939 samples from junior high schools and senior high schools. Data were collected from the Taiwan Education Panel Survey (TEPS. A latent growth curve model was employed to analyze the data. The analysis results are as follows: No gender differences exist regarding the development of SRL and analytical ability in both junior and senior high school students in Taiwan. Junior high school students with higher levels of SRL tend to make less SRL progress during senior high school, whereas students with lower SRL levels tend to make greater progress. Junior high school students with higher family socioeconomic status, greater parental involvement and acceptance, and superior SRL levels demonstrated less SRL progress in senior high school. Additionally, junior high

  17. Concurrent low brain and high liver uptake on FDG PET are associated with cardiovascular risk factors

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Hyun Yeol [Dept. of Nuclear Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon (Korea, Republic of); Jun, Sung Min [Dept. of Nuclear Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan (Korea, Republic of); Pak, Kyoung June; Kim, In Joo [Dept. of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan (Korea, Republic of)

    2017-04-15

    Concurrent low brain and high liver uptake are sometimes observed on fluorine-18-labeled fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET). We investigated the potential clinical significance of this uptake pattern related to metabolic syndrome (MS). We retrospectively reviewed data from 264 consecutive males who had undergone general health check-ups, including FDG PET/CT scans. After an overnight fast, the men had their peripheral blood drawn and the levels of various laboratory parameters measured; an FDG PET/CT scan was performed on the same day. We measured the maximum standardized uptake values of the brain and liver from regions of interest manually placed over the frontal cortex at the level of the centrum semiovale and the right lobe of the liver parenchyma, respectively. Fasting blood glucose (FBG; odds ratio [OR] = 1.063, p < 0.001) and glycated hemoglobin (HbA1c; OR = 3.634, p = 0.010) were the strongest predictive factors for low brain FDG uptake, whereas waist circumference (OR = 1.200, p < 0.001) and γ-glutamyl transpeptidase (OR = 1.012, p = 0.001) were the strongest predictive factors for high liver uptake. Eleven subjects (4.2%) showed concurrent low brain and high liver FDG uptake, and all but one of these subjects (90.9%) had MS. Systolic blood pressure, waist circumference, FBG, triglyceride, alanine aminotransferase, insulin resistance (measured by homeostasis model assessment), insulin, HbA1c, and body mass index were higher in subjects with this FDG uptake pattern than in those without (all, p < 0.001). Concurrent low brain and high liver FDG uptake were closely associated with MS. Moreover, subjects with this pattern had higher values for various cardiovascular risk factors than did those without.

  18. In vivo quantification of {sup 18}F-Fdg uptake in human placenta during early pregnancy

    Energy Technology Data Exchange (ETDEWEB)

    Zanotti-Fregonara, P.; Jan, S.; Trebossen, R.; Maroy, R. [CEA, DSV, I2BM, SHFJ, F-91401 Orsay (France); Champion, C. [Univ Paul Verlaine Metz, Lab Phys Mol et Collis, Inst Phys, Metz (France); Hindie, E. [Hop St Antoine, AP-HP, F-75571 Paris (France); Hindie, E. [Univ Paris 07, IMDCT, IUH, Ecole Doctorale B2T, F-75221 Paris (France)

    2008-07-01

    {sup 18}F-FDG is the most widely used PET radiopharmaceutical. Nevertheless, no data for {sup 18}F-FDG uptake in the human placenta have been reported. We recently reported on embryo dosimetry in a woman who underwent an {sup 18}F-FDG PET/CT scan during early pregnancy. In the present work we attempt an in vivo quantification of the {sup 18}F-FDG uptake by the placenta. The 27-y-old woman received 320 MBq of {sup 18}F-FDG for a follow-up study for Hodgkin's lymphoma and was later discovered to be pregnant (embryo age 8 wk). Imaging started 1 h after injection. The maximum placental tissue uptake (SUVmax) was 2.5. This value was conservatively attributed to the entire placental volume, i.e., 45 mL, a value representative of the average dimensions of a normal placenta at 8 wk. On the basis of these measurements, placenta {sup 18}F-FDG uptake in our patient was 0.19% of the injected activity. A Monte Carlo simulation was used to derive the photon dose to the embryo from the placenta (0.022 * 10{sup -2} mGy per MBq of injected {sup 18}F-FDG) and from the surrounding amniotic fluid (0.017 * 10{sup -2} mGy MBq{sup -1}). This increases our previously calculated dose (3.3 * 10{sup -2} mGy MBq{sup -1}) by only a small fraction (1.18%), which does not justify modifying the previous estimate given the overall uncertainties. (authors)

  19. The value of {sup 18}F-FDG PET/CT in diagnosing infectious endocarditis

    Energy Technology Data Exchange (ETDEWEB)

    Kouijzer, Ilse J.E. [Radboud University Nijmegen Medical Centre, Department of Internal Medicine, P.O. Box 9101, Nijmegen (Netherlands); Vos, Fidel J. [Radboud University Nijmegen Medical Centre, Department of Internal Medicine, P.O. Box 9101, Nijmegen (Netherlands); Sint Maartenskliniek, Nijmegen (Netherlands); Janssen, Marcel J.R. [Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, Nijmegen (Netherlands); Dijk, Arie P.J. van [Radboud University Nijmegen Medical Centre, Department of Cardiology, Nijmegen (Netherlands); Oyen, Wim J.G. [Radboud University Nijmegen Medical Centre, Department of Nuclear Medicine, Nijmegen (Netherlands); Radboud University Nijmegen Medical Centre, Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen (Netherlands); Bleeker-Rovers, Chantal P. [Radboud University Nijmegen Medical Centre, Department of Internal Medicine, P.O. Box 9101, Nijmegen (Netherlands); Radboud University Nijmegen Medical Centre, Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen (Netherlands)

    2013-07-15

    Early detection of infectious endocarditis is challenging. For diagnosing infectious endocarditis, the revised Duke criteria are the gold standard. Evidence of endocardial involvement on echocardiography is a major criterion, but sensitivity and specificity of echocardiography are not optimal. Here we investigated the utility of {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) to diagnose infectious endocarditis in patients with gram-positive bacteraemia. Seventy-two patients with gram-positive bacteraemia were prospectively included. Patients with a positive blood culture growing Staphylococcus aureus, Streptococcus species or Enterococcus species were eligible when a risk factor for developing metastatic infectious foci was present. Infectious endocarditis was defined according to the revised Duke criteria. All patients underwent {sup 18}F-FDG PET/CT and echocardiography. {sup 18}F-FDG uptake in or around the heart valves was evaluated independently by two nuclear medicine physicians. Sensitivity for diagnosing infectious endocarditis with {sup 18}F-FDG PET/CT was 39 % and specificity was 93 %. The positive predictive value was 64 % and negative predictive value was 82 %. The mortality rate in patients without infectious endocarditis and without increased {sup 18}F-FDG uptake in or around the heart valves was 18 %, and in patients without infectious endocarditis but with high {sup 18}F-FDG uptake in or around the heart valves the mortality rate was 50 % (p = 0.181). {sup 18}F-FDG PET/CT is currently not sufficiently adequate for the diagnosis of infectious endocarditis because of its low sensitivity. Improvements such as patient preparation with low carbohydrate-fat allowed diet and technical advances in the newest PET/CT scanners may increase sensitivity in future studies. (orig.)

  20. The findings of F-18 FDG camera-based coincidence PET in acute leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, S. N.; Joh, C. W.; Lee, M. H. [Ajou University School of Medicine, Suwon (Korea, Republic of)

    2002-07-01

    We evaluated the usefulness of F-18 FDG coincidence PET (CoDe-PET) using a dual-head gamma camera in the assessment of patients with acute leukemia. F-18 FDG CoDE-PET studies were performed in 5 patients with acute leukemia (6 ALL and 2 AML) before or after treatment. CoDe-PET was performed utilizing a dual-head gamma camera equipped with 5/8 inch NaI(Tl) crystal. Image acquisition began 60 minutes after the injection of F-18 FDG in the fasting state. A whole trunk from cervical to inguinal regions or selected region were scanned. No attenuation correction was made and image reconstruction was done using filtered back-projection. CoDe-PET studies were evaluated visually. F-18 FDG image performed in 5 patients with ALL before therapy depicted multiple lymph node involvement and diffuse increased uptake involving axial skeleton, pelvis and femurs. F-18 FDG image done in 2 AML after chemotherapy showed only diffuse increased uptake in sternum, ribs, spine, pelvis and proximal femur and these may be due to G-CSF stimulation effect in view of drug history. But bone marrow histology showed scattered blast cell suggesting incomplete remission in one and completer remission in another. F-18 image done in 1 ALL after therapy showed no abnormal uptake. CoDe-PET with F-18 FDG in acute lymphoblastic lymphoma showed multiple lymphnode and bone marrow involvement in whole body. Therefore we conclude that CoDe-PET with F-18 FDG usefulness for evaluation of extent in acute lymphoblastic leukemia. But there was a limitation to assess therapy effectiveness during therapy due to reactive bone marrow.

  1. Comparison of FDG Uptake with Pathological Parameters in the Well-differentiated Thyroid Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Woo Hee; Chung, Yong An; Kim, Ki Jun; Park, Chang Suk; Jung, Hyun Suk; Sohn, Hyung Sun; Chung, Soo Kyo; Yoo, Chang Young [College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of)

    2009-02-15

    Differentiated thyroid cancer (DTC) has variable degree of F-18 FDG avidity. The purpose of this study was to evaluate the relationship between F-18 FDG uptake and pathological or immunohistochemical features of DTC. DTC patients who underwent both pre-operative F-18 FDG PET/CT scan and surgery were included in the study. Maximum standardized uptake values (SUVmax) of primary tumor were calculated. If the primary tumor showed no perceptibly increased F-18 FDG uptake, region of interest was drawn based on finding of CT portion of the PET/CT images. Pathological and immunohistochemical markers such as presence of lymph node (LN) metastasis and underlying thyroiditis, tumor size, Ki-67 labeling index, expressions of EGFR, COX-2, and Galectin-3 were evaluated. Total of 106 patients was included (102 papillary carcinomas, 4 follicular carcinomas). The mean SUVmax of the large tumors (above 1 cm) was significantly higher than the mean SUVmax of small (equal to or less than 1 cm) ones (7.8{+-}8.5 vs. 3.6{+-}3.1, p=0.004). No significant difference in F-18 FDG uptake was found according to the presence or absence of LN metastasis and underlying thyroiditis, or the degree of Ki-67 labeling index, expression of EGFR, COX-2 and Galectin-3. In conclusion, the degree of F-18 FDG uptake in DTC was associated with the size of primary tumor. But there seem to be no relationship between F-18 FDG uptake of DTC and expression of Ki-67, EGFR, COX-2 and Galectin-3.

  2. The value of 18F-FDG PET/CT in diagnosing infectious endocarditis.

    Science.gov (United States)

    Kouijzer, Ilse J E; Vos, Fidel J; Janssen, Marcel J R; van Dijk, Arie P J; Oyen, Wim J G; Bleeker-Rovers, Chantal P

    2013-07-01

    Early detection of infectious endocarditis is challenging. For diagnosing infectious endocarditis, the revised Duke criteria are the gold standard. Evidence of endocardial involvement on echocardiography is a major criterion, but sensitivity and specificity of echocardiography are not optimal. Here we investigated the utility of (18)F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) to diagnose infectious endocarditis in patients with gram-positive bacteraemia. Seventy-two patients with gram-positive bacteraemia were prospectively included. Patients with a positive blood culture growing Staphylococcus aureus, Streptococcus species or Enterococcus species were eligible when a risk factor for developing metastatic infectious foci was present. Infectious endocarditis was defined according to the revised Duke criteria. All patients underwent (18)F-FDG PET/CT and echocardiography. (18)F-FDG uptake in or around the heart valves was evaluated independently by two nuclear medicine physicians. Sensitivity for diagnosing infectious endocarditis with (18)F-FDG PET/CT was 39% and specificity was 93%. The positive predictive value was 64% and negative predictive value was 82%. The mortality rate in patients without infectious endocarditis and without increased (18)F-FDG uptake in or around the heart valves was 18%, and in patients without infectious endocarditis but with high (18)F-FDG uptake in or around the heart valves the mortality rate was 50% (p = 0.181). (18)F-FDG PET/CT is currently not sufficiently adequate for the diagnosis of infectious endocarditis because of its low sensitivity. Improvements such as patient preparation with low carbohydrate-fat allowed diet and technical advances in the newest PET/CT scanners may increase sensitivity in future studies.

  3. FDG-PET/CT for differentiating between aseptic and septic delayed union in the lower extremity.

    Science.gov (United States)

    van Vliet, Kirsten E; de Jong, Vincent M; Termaat, M Frank; Schepers, Tim; van Eck-Smit, Berthe L F; Goslings, J Carel; Schep, Niels W L

    2017-09-27

    (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) has proven to have a high diagnostic accuracy for the detection of bone infections. In patients with delayed union it may be clinically important to differentiate between aseptic and septic delayed union. The aim of this study was to evaluate the efficacy and to assess the optimal diagnostic accuracy of FDG-PET/CT in differentiating between aseptic and septic delayed union in the lower extremity. This is a retrospective study of consecutive patients who underwent FDG-PET/CT scanning for suspicion of septic delayed union of the lower extremity. Diagnosis of aseptic delayed union or septic delayed union was made based on surgical deep cultures following PET/CT scanning and information on clinical follow-up. FDG-uptake values were measured at the fractured site by use of the maximum standardized uptake value (SUVmax). Sensitivity, specificity and diagnostic accuracy of FDG-PET/CT were calculated at various SUVmax cut-off points. A total of 30 patients were included; 13 patients with aseptic delayed unions and 17 patients with septic delayed unions. Mean SUVmax in aseptic delayed union patients was 3.23 (SD ± 1.21). Mean SUVmax in septic delayed union patients was 4.77 (SD ± 1.87). A cut-off SUVmax set at 4.0 showed sensitivity, specificity and diagnostic accuracy of FDG-PET/CT were 65, 77 and 70% to differentiate between aseptic and septic delayed union, respectively. Using a semi-quantitative measure (SUVmax) for interpretation of FDG-PET/CT imaging seems to be a promising tool for the discrimination between aseptic and septic delayed union.

  4. FDG uptake in vaginal tampons is caused by urinary contamination and related to tampon position

    Energy Technology Data Exchange (ETDEWEB)

    Burger, Irene A.; Crook, David W.; Treyer, Valerie; Hany, Thomas F.; Schulthess, Gustav K. von [University Hospital of Zurich, Division of Nuclear Medicine, Department of Medical Radiology, Zurich (Switzerland); Scheiner, David A. [University Hospital of Zurich, Division of Obstetrics and Gynecology, Zurich (Switzerland)

    2011-01-15

    The aim of the study was to determine the aetiology of FDG uptake in vaginal tampons (VT), a known artefact in premenopausal women evaluated by PET/CT. This Institutional Review Board approved study consisted of retrospective and prospective parts. The retrospective analysis included 685 women examined between January 2008 and December 2009 regarding VT presence. PET/CT images were analysed to determine the localization and the standardized uptake value (SUV) of VTs. We prospectively recruited 24 women (20-48 years old) referred for staging or follow-up in an oncology setting between February and April 2010, who were provided a commercial VT to be used during the entire examination after obtaining written informed consent. After image acquisition, VTs were individually analysed for creatinine concentration and blood traces. Statistical significance was tested with the Mann-Whitney U test. In the retrospective part, 38 of 685 women were found to have a VT of which 17 (45%) were FDG positive. A statistically significant correlation was found between FDG activity and VT position below the pubococcygeal line (PCL) (13 {+-} 11.2 mm). In the prospective study, 7 of 24 (29%) women had increased FDG activity in their VTs (SUV 18.8 {+-} 11 g/ml) but were not menstruating. FDG-positive VTs were significantly lower in position (14.6 {+-} 11.4 mm,below the PCL) than FDG-negative VTs (p = 0.039). The creatinine concentration was significantly increased in all seven positive VTs (931 {+-} 615 {mu}mol/l). FDG uptake in VTs is caused by urine contamination, which is likely related to localization below the PCL resulting in contact with urine during voiding. (orig.)

  5. FDG-PET in the initial staging of squamous cell oesophageal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Buchmann, I.; Schreckenberger, M.; Bartenstein, P. [Dept. of Nuclear Medicine, Univ. Hospital Mainz (Germany); Hansen, T. [Inst. of Pathology, Univ. Hospital, Jena (Germany); Inst. of Pathology, Univ. Hospital, Mainz (Germany); Brochhausen, C. [Inst. of Pathology, Univ. Hospital, Mainz (Germany); Kneist, W.; Junginger, T. [Dept. of Surgery, Univ. Hospital Mainz (Germany); Oberholzer, K. [Dept. of Radiology, Univ. Hospital Mainz (Germany)

    2006-07-01

    Squamous cell oesophageal carcinoma is the most common carcinoma of the oesophagus worldwide. The tumour stage as most important prognostic factor determines the clinical management. Aim of this study was to evaluate the value of FDG-PET 1. in imaging the primary tumour and 2. in N- and M-staging of squamous cell oesophogeal carcinoma. Patients, methods: in 20 patients with histological proven squamous cell carcinoma of the upper and middle oesophagus, FDG-PET was performed in standard technique prior to therapy. FDG uptake in the primary was determined by calculation of the SUVmax. NM-staging due to PET findings was performed as designated by the AJCC/UICC group classification and was compared with pathological and clinically based staging. Sensitivities, specificities and accuracies were calculated. Results: in 19 of 20 patients, primary squamous cell oesopohageal carcinoma was detected by FDG-PET findings with a maximum SUV of 12.5 (mean) {+-} 5.1 (median 11.5; range 4.8-23.8). One carcinoma in situ was missed. The sensitivity of FDG-PET in imaging the primary tumour was 96%. The sensitivities, specificities and accuracies were 20%, 100%, 58% for N-staging, and 60%, 86% and 93% for M-staging. PET findings caused changes of therapy in 5% (1 patient). Conclusions: FDG-PET was excellent in imaging the primary of squamous cell oesophageal carcinoma in stage T1-T4 and was efficient in M-staging. The low sensitivity in N-staging is of inferior clinical importance. The efficacy of FDG-PET seems to be not significantly be influenced by the histological subtype of oesophageal carcinoma. (orig.)

  6. Comparisons of methods for quantitative analysis of lung lesions using FDG-PET

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Joon Young; Choi, Yong; Kim, Sang Eun; Choe, Yearn Seong; Lee, Kyung Han; Kim, Yong Jin; Kim, Byung Tae [Hanyang Univ., Seoul (Korea, Republic of)

    1997-07-01

    It has been demonstrated that quantitative analysis approaches could improve the accuracy of FDG-PET in identifying malignant lesions. In order to evaluate the diagnostic accuracy of various quantitative analysis methods of FDG-PET in differentiating malignant from benign lung masses, 22 patients (malignant: 13, benign: 9) were studied after overnight fasting. Dynamic images were acquired for 56 min after i.v. injection of about 370 MBq (10 mCi) of FDG using a GE Advance tomograph and reconstructed with photon attenuation correction. Standardized uptake values normalized to patient's body weight and plasma glucose concentration (SUVglu) were calculated. The uptake rate constant of FDG and glucose metabolic rates were quantified using Patlak graphical analysis (Kpat and MRpat, respectively), three compartment- five parameter model (K5p, MR5p), and six parameter model taking into account heterogeneity of tumor tissue (K6p, MR6p, Wu et al. 1995). Input functions were derived from a ROI in the left atrium blood pool. The lumped constant of the FDG model was assumed to be a constant value of 1. Areas under receiver operating characteristics curves (ROC) were calculated for each analysis. The six parameter and Patlak graphical analysis approaches are superior to nonkinetic analysis. Plasma glucose concentration needs to be taken into account for quantitative analysis of FDG-PET lung cancer studies. Although quantitative assessment could not differentiate some high metabolic benign lesions such as active inflammation from malignant lesions, it may improve the utility of FDG-PET by providing quantitative values and by reducing interobserver variability.

  7. Benign and malignant neurogenic tumors of nerve sheath origin on FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Yun, M. J.; Go, D. H.; Yoo, Y. H.; Shin, K. H.; Lee, J. D [College of Medicine, Yonsei University, Seoul (Korea, Republic of)

    2004-07-01

    The differentiation between benign and malignant nerve sheath tumors is difficult based on conventional radiological imaging. This study was undertaken to investigate the value of FDG PET in distinguishing benign from malignant neurogenic tumors of nerve sheath origin. We performed a retrospective review of the medical record to select patients with nerve sheath tumors who had underdone FDG PET imaging. Fifteen patients (7F: 8M) with benign or malignant nerve sheath tumors were included in this study. Of the 15 patients, 9 were diagnosed with the known neurofibromatosis type I. A total of 19 nerve sheath tumors were included from the 15 patients. All patients had undergone FDG PET to evaluate for malignant potential of the known lesions. Images of FDG PET were semi-quantitatively analyzed and a region of interest (ROI) was placed over the area of the maximum FDG uptake and an average standardized uptake value was taken for final analysis. There were 5 malignant peripheral nerve sheath tumors, 5 schwannomas, and 9 neurofibromas. The mean SUV was 2 (ranged from 1.6 to 3.3) for schwannomas, 1.3 (0.7 to 2.5) for neurofibromas, and 8.4 (4.6 to 12.2) for malignant peripheral nerve sheath tumors. Of 14 benign tumors, all except one schwannoma showed a SUV less than 3. When a cutoff SUV of 4 was used to differentiate the nerve sheath tumors, all tumors were correctly classified as benign or malignant, respectively. Among the 9 patients diagnosed with neurofibromatosis type I. 4 had malignant peripheral nerve sheath tumors and FDG PET accurately detected all the 4 lesions with malignant transformation. According to our results, FDG PET seems to have a great potential for accurately characterizing benign versus malignant nerve sheath tumors. It appears to be extremely useful for patients with neurofibromatosis to localize the lesion with malignant transformation.

  8. Intraindividual homogeneity of (18)F-FDG PET/CT parameters in HPV-positive OPSCC.

    Science.gov (United States)

    Sharma, Shachi Jenny; Wittekindt, Claus; Knuth, Jennifer; Steiner, Dagmar; Wuerdemann, Nora; Laur, Maren; Kroll, Tobias; Wagner, Steffen; Klussmann, Jens Peter

    2017-10-01

    (18)F-FDG PET/CT is widely used in clinical oncology. Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) represents an emerging disease that differs from HPV-negative OPSCC in clinical behavior and tumour biology. In these tumours, HPV-oncogenes might lead to distinct alterations in metabolic pathways. Therefore, we compared metabolic parameters using (18)F-FDG PET/CT in HPV-positive and HPV-negative OPSCC in relation to histopathological findings. Eighty-six patients with OPSCC received pre-therapeutic (18)F-FDG PET/CT. Standardised uptake volume (SUV), total lesion glycolysis (TLG) and metabolic tumour volume (MTV) were analysed for the primary tumour. SUVmax was determined for neck lymph nodes. HPV-status was determined; overall survival rates (OS) were estimated. 32/86 patients (37.2%) had HPV-related OPSCC. Overall, PET-parameters in primary tumours of both groups did not differ significantly. Comparing early with locally advanced primary tumours, there was a significant increase in (18)F-FDG uptake in HPV-negative patients (pHPV-related OPSCC showed significantly higher SUVmax values (p=0.039) compared to HPV-negative OPSCC. Strikingly, there was a higher intraindividual homogeneity of (18)F-FDG uptake between primary and respective positive nodes in HPV-related primary OPSCC (p=0.001). SUV-max and -mean values did not correlate with OS in HPV-related OPSCC. The intraindividual homogeneity of 18F-FDG uptake in HPV-related OPSCC could reflect the more homogenously, HPV-triggered carcinogenesis compared to the mutation-driven carcinogenesis in the HPV-negative OPSCC with heterogenic (18)F-FDG uptake. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. HPLC and TLC methods for analysis of [18F]FDG and its metabolites from biological samples.

    Science.gov (United States)

    Rokka, Johanna; Grönroos, Tove J; Viljanen, Tapio; Solin, Olof; Haaparanta-Solin, Merja

    2017-03-24

    The most used positron emission tomography (PET) tracer, 2-[ 18 F]fluoro-2-deoxy-d-glucose ([ 18 F]FDG), is a glucose analogue that is used to measure tissue glucose consumption. Traditionally, the Sokoloff model is the basis for [ 18 F]FDG modeling. According to this model, [ 18 F]FDG is expected to be trapped in a cell in the form of [ 18 F]FDG-6-phosphate ([ 18 F]FDG-6-P). However, several studies have shown that in tissues, [ 18 F]FDG metabolism goes beyond [ 18 F]FDG-6-P. Our aim was to develop radioHPLC and radioTLC methods for analysis of [ 18 F]FDG metabolites from tissue samples. The radioHPLC method uses a sensitive on-line scintillation detector to detect radioactivity, and the radioTLC method employs digital autoradiography to detect the radioactivity distribution on a TLC plate. The HPLC and TLC methods were developed using enzymatically in vitro-produced metabolites of [ 18 F]FDG as reference standards. For this purpose, three [ 18 F]FDG metabolites were synthesized: [ 18 F]FDG-6-P, [ 18 F]FD-PGL, and [ 18 F]FDG-1,6-P2. The two methods were evaluated by analyzing the [ 18 F]FDG metabolic profile from rodent ex vivo tissue homogenates. The HPLC method with an on-line scintillation detector had a wide linearity in a range of 5Bq-5kBq (LOD 46Bq, LOQ 139Bq) and a good resolution (Rs ≥1.9), and separated [ 18 F]FDG and its metabolites clearly. The TLC method combined with digital autoradiography had a high sensitivity in a wide range of radioactivity (0.1Bq-2kBq, LOD 0.24Bq, LOQ 0.31Bq), and multiple samples could be analyzed simultaneously. As our test and the method validation with ex vivo samples showed, both methods are useful, and at best they complement each other in analysis of [ 18 F]FDG and its radioactive metabolites from biological samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Clinical Value of FDG-PET/CT for the Evaluation of Rheumatic Diseases: Rheumatoid Arthritis, Polymyalgia Rheumatica, and Relapsing Polychondritis.

    Science.gov (United States)

    Kubota, Kazuo; Yamashita, Hiroyuki; Mimori, Akio

    2017-07-01

    FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. Elevated FDG uptake by active inflammatory tissues, such as those affected by arthritis, vasculitis, lymphadenitis, and chondritis, has enabled the diagnosis of inflammatory diseases using FDG-PET/CT. Rheumatoid arthritis (RA) is a systemic, chronic inflammation of the joints resulting in synovitis. Several clinical studies of RA have demonstrated that FDG uptake in affected joints reflects the disease activity of RA, with strong correlations between FDG uptake and various clinical parameters having been noted. Furthermore, the use of FDG-PET for the sensitive detection and early monitoring of the response to RA therapy has been reported. RA is sometimes associated with subclinical vasculitis, which is related to systemic inflammation. FDG