WorldWideScience

Sample records for technology targets peak

  1. Impact of Smart Grid Technologies on Peak Load to 2050

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    The IEA's Smart Grids Technology Roadmap identified five global trends that could be effectively addressed by deploying smart grids. These are: increasing peak load (the maximum power that the grid delivers during peak hours), rising electricity consumption, electrification of transport, deployment of variable generation technologies (e.g. wind and solar PV) and ageing infrastructure. Along with this roadmap, a new working paper -- Impact of Smart Grid Technologies on Peak Load to 2050 -- develops a methodology to estimate the evolution of peak load until 2050. It also analyses the impact of smart grid technologies in reducing peak load for four key regions; OECD North America, OECD Europe, OECD Pacific and China. This working paper is a first IEA effort in an evolving modelling process of smart grids that is considering demand response in residential and commercial sectors as well as the integration of electric vehicles.

  2. An analysis of China's CO2 emission peaking target and pathways

    Directory of Open Access Journals (Sweden)

    Jian-Kun He

    2014-12-01

    Full Text Available China has set the goal for its CO2 emissions to peak around 2030, which is not only a strategic decision coordinating domestic sustainable development and global climate change mitigation but also an overarching target and a key point of action for China's resource conservation, environmental protection, shift in economic development patterns, and CO2 emission reduction to avoid climate change. The development stage where China maps out the CO2 emission peak target is earlier than that of the developed countries. It is a necessity that the non-fossil energy supplies be able to meet all the increased energy demand for achieving CO2 emission peaking. Given that China's potential GDP annual increasing rate will be more than 4%, and China's total energy demand will continue to increase by approximately 1.0%–1.5% annually around 2030, new and renewable energies will need to increase by 6%–8% annually to meet the desired CO2 emission peak. The share of new and renewable energies in China's total primary energy supply will be approximately 20% by 2030. At that time, the energy consumption elasticity will decrease to around 0.3, and the annual decrease in the rate of CO2 intensity will also be higher than 4% to ensure the sustained growth of GDP. To achieve the CO2 emission peaking target and substantially promote the low-carbon development transformation, China needs to actively promote an energy production and consumption revolution, the innovation of advanced energy technologies, the reform of the energy regulatory system and pricing mechanism, and especially the construction of a national carbon emission cap and trade system.

  3. Technology for computer-stabilized peak of NaI(Tl) gamma spectrum

    International Nuclear Information System (INIS)

    Chen Jianzhen; Guo Lanying; Ling Qiu; Qu Guopu; Zhao Lihong; Hu Chuangye

    2005-01-01

    An improved technology for spectrum stabilization of NaI(Tl) gamma spectrum was introduced. This technology is based on the system using a reference peak, which is equivalent gamma peak of 241 Am source. The computer seeks peak's position deviation and computes adjust value of programmable amplifier and controls programmable amplifier to stabilize spectrum by digital PID. This is a technology of spectrum stabilizing with 'hardware + reference-peak + software' and has high stability and fast speed of spectrum stabilizing. (author)

  4. Estimation of peak heat flux onto the targets for CFETR with extended divertor leg

    International Nuclear Information System (INIS)

    Zhang, Chuanjia; Chen, Bin; Xing, Zhe; Wu, Haosheng; Mao, Shifeng; Luo, Zhengping; Peng, Xuebing; Ye, Minyou

    2016-01-01

    Highlights: • A hypothetical geometry is assumed to extend the outer divertor leg in CFETR. • Density scan SOLPS simulation is done to study the peak heat flux onto target. • Attached–detached regime transition in out divertor occurs at lower puffing rate. • Unexpected delay of attached–detached regime transition occurs in inner divertor. - Abstract: China Fusion Engineering Test Reactor (CFETR) is now in conceptual design phase. CFETR is proposed as a good complement to ITER for demonstrating of fusion energy. Divertor is a crucial component which faces the plasmas and handles huge heat power for CFETR and future fusion reactor. To explore an effective way for heat exhaust, various methods to reduce the heat flux to divertor target should be considered for CFETR. In this work, the effect of extended out divertor leg on the peak heat flux is studied. The magnetic configuration of the long leg divertor is obtained by EFIT and Tokamak Simulation Code (TSC), while a hypothetical geometry is assumed to extend the out divertor leg as long as possible inside vacuum vessel. A SOLPS simulation is performed to study peak heat flux of the long leg divertor for CFETR. D 2 gas puffing is used and increasing of the puffing rate means increase of plasma density. Both peak heat flux onto inner and outer targets are below 10 MW/m 2 is achieved. A comparison between the peak heat flux between long leg and conventional divertor shows that an attached–detached regime transition of out divertor occurs at lower gas puffing gas puffing rate for long leg divertor. While for the inner divertor, even the configuration is almost the same, the situation is opposite.

  5. Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Abdul Hadi Mohd

    2014-05-01

    Full Text Available Objective(s: The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. Materials and Methods:Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and pH-sensitive polymers which were further filled into an empty HPMC capsule. To assess the compatibility, FT-IR and DSC studies for pure drug, polymers and their physical mixture were performed. The formulated batches were subjected to physicochemical studies, estimation of drug content, in vitro drug release, drug release kinetics, and stability studies. Results:  When FTIR and DSC studies were performed it was found that there was no interaction between lornoxicam and polymers which used. All the physicochemical properties of prepared matrix-mini-tablets were found to be in normal limits. The percentage of drug content was found to be 99.60±0.07%. Our optimized matrix mini-tablets-filled-capsule formulation F30 released lornoxicam after a lag time of 5.02±0.92 hr, 95.48±0.65 % at the end of 8 hr and 99.90±0.83 % at the end of 12 hr. Stability was also found for this formulation as per the guidelines of International Conference on Harmonisation of Technical Requirements of Pharmaceuticals for Human Use. Conclusion: A novel colon targeted delivery system of lornoxicam was successfully developed by filling matrix-mini-tablets into an empty HPMC capsule shell for targeting early morning peak symptoms of rheumatoid arthritis.

  6. Modified egg as a nutritional supplement during peak brain development: a new target for fortification.

    Science.gov (United States)

    Shapira, Niva

    2009-01-01

    Though eggs have the unique capacity, like breastmilk, to concentrate essential nutrients required for early growth and brain development of offspring - i.e. n-3 PUFA, increasingly deficient and sources contaminated - cholesterol and allergy concerns often exclude them from perinatal recommendations. Egg's potential contribution of key nutrients required for peak brain development are re-evaluated vis-à-vis fortification, accessibility, and risks. Contributions of standard (USDA) and fortified (selected market-available) egg compositions to perinatal requirements for critical brain-supporting nutrients were compared to human and cow milks, and risks and recommendations evaluated. Standard egg has already higher concentrations/kcal of iron, selenium, zinc, choline, vitamins B12 and E, and essential amino acids (plus taurine) than human milk. Fortified egg could further yield significant n-3 PUFA % recommendations for pregnancy-lactation (total n-3 69.6-75.0% [DRI=1400-1300 mg/day]), including DHA (120.1-129.3%, mostly approximately 80% [calculated DRI=140-130 mg/day]), plus antioxidant vitamins A (9.0-15.2%) and E (51.6-65.3%), and minerals iodine (33.6-44.5%) and selenium (33.7-39.3%); % recommendations for children (1-3 y) even more. Cholesterol, important for nerve membranes and learning, may not be generally contraindicated in childbearing-aged women (approximately 10.5% hypercholesterolemia), and early-life egg exposure may increase tolerance. Egg-inclusive perinatal nutrition programs have shown significant contributions. Eggs, especially target-fortified, may provide a unique nutritional supplement for peak brain development continously during pregnancy, nursing, and infancy (from 6 months), especially vs. insufficiencies. Missing nutritional opportunities by egg exclusion vs. concerns of hypercholesterolemia or allergy could be addressed individually, rather than as general recommendations, warranting further research and targeted egg design.

  7. Using vehicle-to-grid technology for frequency regulation and peak-load reduction

    Science.gov (United States)

    White, Corey D.; Zhang, K. Max

    This paper explores the potential financial return for using plug-in hybrid electric vehicles as a grid resource. While there is little financial incentive for individuals when the vehicle-to-grid (V2G) service is used exclusively for peak reduction, there is a significant potential for financial return when the V2G service is used for frequency regulation. We propose that these two uses for V2G technology are not mutually exclusive, and that there could exist a "dual-use" program that utilizes V2G for multiple uses simultaneously. In our proposition, V2G could be used for regulation on a daily basis to ensure profits, and be used for peak reduction on days with high electricity demand and poor ambient air quality in order to reap the greatest environmental benefits. The profits for the individual in this type of dual-use program are close to or even higher than the profits experienced in either of the single-use programs. More importantly, we argue that the external benefits of this type of program are much greater as well. At higher V2G participation rates, our analysis shows that the market for regulation capacity could become saturated by V2G-based regulation providers. At the same time, there is plenty of potential for widespread use of V2G technology, especially if the demand for regulation, reserves, and storage grows as more intermittent renewable resources are being incorporated into the power systems.

  8. Analysis of the need for intermediate and peaking technologies in the year 2000

    Energy Technology Data Exchange (ETDEWEB)

    Barrager, S.M.; Campbell, G.L.

    1980-04-01

    This analysis was conducted to assess the impact of load management on the future need for intermediate- and peak-generating technologies (IPTs) such as combustion turbines, pumped storage, and cycling coal plants. There will be a reduced need for IPTs if load-management activities such as time-of-use pricing, together with customer-owned energy-storage devices, hot-water-heater controls, and interruptible service, can economically remove most of the variation from electric-power demands. Therefore, the analysis assesses the need for IPTs in an uncertain future, which will probably include load management and time-differentiated electricity prices. Section 2 provides a condensed description of the models used in the analysis. (Details and data sets are contained in the appendixes.) Results of sensitivities on growth rates, model parameters, and appliance saturations are discussed in Section 3, which also contains the analysis of the potential impacts of customer energy storage, appliance control, and time-of-use pricing. The future need for intermediate and peaking technologies is analyzed in Section 4.

  9. Future technological developments to fulfill AG2020 targets

    DEFF Research Database (Denmark)

    Markussen, Mads Ville; Østergård, Hanne; Borch, Kristian

    2010-01-01

    . Based on the technological narratives and imperatives, we select a set of present available technologies that are able to support the society in reaching the targets set up by AG2020. For each of these technologies, we evaluate the strengths and weaknesses of the technology to reach the target as well...

  10. Realizing Technologies for Magnetized Target Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Wurden, Glen A. [Los Alamos National Laboratory

    2012-08-24

    Researchers are making progress with a range of magneto-inertial fusion (MIF) concepts. All of these approaches use the addition of a magnetic field to a target plasma, and then compress the plasma to fusion conditions. The beauty of MIF is that driver power requirements are reduced, compared to classical inertial fusion approaches, and simultaneously the compression timescales can be longer, and required implosion velocities are slower. The presence of a sufficiently large Bfield expands the accessibility to ignition, even at lower values of the density-radius product, and can confine fusion alphas. A key constraint is that the lifetime of the MIF target plasma has to be matched to the timescale of the driver technology (whether liners, heavy ions, or lasers). To achieve sufficient burn-up fraction, scaling suggests that larger yields are more effective. To handle the larger yields (GJ level), thick liquid wall chambers are certainly desired (no plasma/neutron damage materials problem) and probably required. With larger yields, slower repetition rates ({approx}0.1-1 Hz) for this intrinsically pulsed approach to fusion are possible, which means that chamber clearing between pulses can be accomplished on timescales that are compatible with simple clearing techniques (flowing liquid droplet curtains). However, demonstration of the required reliable delivery of hundreds of MJ of energy, for millions of pulses per year, is an ongoing pulsed power technical challenge.

  11. The partitioning of nanoparticles to endothelium or interstitium during ultrasound-microbubble-targeted delivery depends on peak-negative pressure

    Energy Technology Data Exchange (ETDEWEB)

    Hsiang, Y.-H.; Song, J.; Price, R. J., E-mail: rprice@virginia.edu [University of Virginia, Department of Biomedical Engineering (United States)

    2015-08-15

    Patients diagnosed with advanced peripheral arterial disease often face poor prognoses and have limited treatment options. For some patient populations, the therapeutic growth of collateral arteries (i.e. arteriogenesis) that bypass regions affected by vascular disease may become a viable treatment option. Our group and others are developing therapeutic approaches centered on the ability of ultrasound-activated microbubbles to permeabilize skeletal muscle capillaries and facilitate the targeted delivery of pro-arteriogenic growth factor-bearing nanoparticles. The development of such approaches would benefit significantly from a better understanding of how nanoparticle diameter and ultrasound peak-negative pressure affect both total nanoparticle delivery and the partitioning of nanoparticles to endothelial or interstitial compartments. Toward this goal, using Balb/C mice that had undergone unilateral femoral artery ligation, we intra-arterially co-injected nanoparticles (50 and 100 nm) with microbubbles, applied 1 MHz ultrasound to the gracilis adductor muscle at peak-negative pressures of 0.7, 0.55, 0.4, and 0.2 MPa, and analyzed nanoparticle delivery and distribution. As expected, total nanoparticle (50 and 100 nm) delivery increased with increasing peak-negative pressure, with 50 nm nanoparticles exhibiting greater tissue coverage than 100 nm nanoparticles. Of particular interest, increasing peak-negative pressure resulted in increased delivery to the interstitium for both nanoparticle sizes, but had little influence on nanoparticle delivery to the endothelium. Thus, we conclude that alterations to peak-negative pressure may be used to adjust the fraction of nanoparticles delivered to the interstitial compartment. This information will be useful when designing ultrasound protocols for delivering pro-arteriogenic nanoparticles to skeletal muscle.

  12. The partitioning of nanoparticles to endothelium or interstitium during ultrasound-microbubble-targeted delivery depends on peak-negative pressure

    International Nuclear Information System (INIS)

    Hsiang, Y.-H.; Song, J.; Price, R. J.

    2015-01-01

    Patients diagnosed with advanced peripheral arterial disease often face poor prognoses and have limited treatment options. For some patient populations, the therapeutic growth of collateral arteries (i.e. arteriogenesis) that bypass regions affected by vascular disease may become a viable treatment option. Our group and others are developing therapeutic approaches centered on the ability of ultrasound-activated microbubbles to permeabilize skeletal muscle capillaries and facilitate the targeted delivery of pro-arteriogenic growth factor-bearing nanoparticles. The development of such approaches would benefit significantly from a better understanding of how nanoparticle diameter and ultrasound peak-negative pressure affect both total nanoparticle delivery and the partitioning of nanoparticles to endothelial or interstitial compartments. Toward this goal, using Balb/C mice that had undergone unilateral femoral artery ligation, we intra-arterially co-injected nanoparticles (50 and 100 nm) with microbubbles, applied 1 MHz ultrasound to the gracilis adductor muscle at peak-negative pressures of 0.7, 0.55, 0.4, and 0.2 MPa, and analyzed nanoparticle delivery and distribution. As expected, total nanoparticle (50 and 100 nm) delivery increased with increasing peak-negative pressure, with 50 nm nanoparticles exhibiting greater tissue coverage than 100 nm nanoparticles. Of particular interest, increasing peak-negative pressure resulted in increased delivery to the interstitium for both nanoparticle sizes, but had little influence on nanoparticle delivery to the endothelium. Thus, we conclude that alterations to peak-negative pressure may be used to adjust the fraction of nanoparticles delivered to the interstitial compartment. This information will be useful when designing ultrasound protocols for delivering pro-arteriogenic nanoparticles to skeletal muscle

  13. Materials technology applied to nuclear accelerator targets

    International Nuclear Information System (INIS)

    Barthell, B.L.

    1986-01-01

    The continuing requests for both shaped and flat, very low areal density metal foils have led to the development of metallurgical quality, high strength products. Intent of this paper is to show methods of forming structures on various substrates using periodic vapor interruptions, alternating anodes, and mechanical peening to alter otherwise unacceptable grain morphology which both lowers tensile strength and causes high stresses in thin films. The three technologies, physical vapor deposition, electrochemistry, and chemical vapor deposition and their thin film products can benefit from the use of laminate technology and control of grain structure morphology through the use of materials research and technology

  14. Targeted Technology Transfer to US Independents

    Energy Technology Data Exchange (ETDEWEB)

    Donald F. Duttlinger; E. Lance Cole

    2006-09-29

    The Petroleum Technology Transfer Council (PTTC) was established by domestic crude oil and natural gas producers in 1994 as a national not-for-profit organization to address the increasingly urgent need to improve the technology-transfer process in the U.S. upstream petroleum industry. Coordinated from a Headquarters (HQ) office in Houston, PTTC maintains an active grassroots program executed by 10 Regional Lead Organizations (RLOs) and two satellite offices (Figure 1). Regional Directors interact with domestic oil and gas producers through technology workshops, resource centers, websites, newsletters, technical publications and cooperative outreach efforts. HQ facilitates inter-regional technology transfer and implements a comprehensive communications program. Active volunteers on the National Board and in Producer Advisory Groups (PAGs) in each of the 10 regions focus effort in areas that will create the most impact for domestic producers. Focused effort by dedicated individuals across the country has enabled PTTC to achieve the milestones outlined in Appendix A.

  15. Diabetic footwear: is it an assistive technology capable of reducing peak plantar pressures in elderly patients with neuropathy?

    Directory of Open Access Journals (Sweden)

    Alexandre Faraco de Oliveira

    Full Text Available Abstract Introduction: Diabetes Mellitus is a chronic disease with high prevalence in the population in particular among the elderly. The longer time of diabetes, increased the chances of developing complications such as peripheral neuropathy, which is an important factor in the genesis of plantar lesions by changing the distribution and formation of plantar pressure peaks. Objective: Evaluate the influence of an Assistive Technology, therapeutic footwear for diabetics, in the peaks of plantar pressure of elderly. Methods: This was an experimental study of transversal type, composed by 10 elderly, diabetic, with peripheral neuropathy, using as an instrument to measure a baropodometry platform. Were measured peaks of plantar pressure, static and dynamic in three situations: barefoot, the participants' own standard footwear and with therapeutic footwear for diabetics. Data analysis by normal distribution as a single paired sample, applying the ANOVA test. Results: The use of therapeutic footwear for diabetics promoted a reduction in media of peak plantar pressure in the order of 22% in static analysis, and 31% in dynamic analysis. Conclusion: The therapeutic footwear for diabetics was able to produce significant reductions in peak plantar pressure, being more efficient than a common footwear. This effect may contribute to the prevention of injuries associated with the diabetic foot.

  16. Transrectal real-time tissue elastography targeted biopsy coupled with peak strain index improves the detection of clinically important prostate cancer.

    Science.gov (United States)

    Ma, Qi; Yang, Dong-Rong; Xue, Bo-Xin; Wang, Cheng; Chen, Han-Bin; Dong, Yun; Wang, Cai-Shan; Shan, Yu-Xi

    2017-07-01

    The focus of the present study was to evaluate transrectal real-time tissue elastography (RTE)-targeted two-core biopsy coupled with peak strain index for the detection of prostate cancer (PCa) and to compare this method with 10-core systematic biopsy. A total of 141 patients were enrolled for evaluation. The diagnostic value of peak strain index was assessed using a receiver operating characteristic curve. The cancer detection rates of the two approaches and corresponding positive cores and Gleason score were compared. The cancer detection rate per core in the RTE-targeted biopsy (44%) was higher compared with that in systematic biopsy (30%). The peak strain index value of PCa was higher compared with that of the benign lesion. PCa was detected with the highest sensitivity (87.5%) and specificity (85.5%) using the threshold value of a peak strain index of ≥5.97 with an area under the curve value of 0.95. When the Gleason score was ≥7, RTE-targeted biopsy coupled with peak strain index detected 95.6% of PCa cases, but 84.4% were detected using systematic biopsy. Peak strain index as a quantitative parameter may improve the differentiation of PCa from benign lesions in the prostate peripheral zone. Transrectal RTE-targeted biopsy coupled with peak strain index may enhance the detection of clinically significant PCa, particularly when combined with systematic biopsy.

  17. TARGETED TECHNOLOGY TRANSFER TO US INDEPENDENTS

    Energy Technology Data Exchange (ETDEWEB)

    Donald F. Duttlinger; E. Lance Cole

    2005-01-01

    The Petroleum Technology Transfer Council (PTTC) continued pursuing its mission of assisting U.S. independent oil and gas producers with timely, informed technology decisions during Fiscal Year 2004 (FY04). PTTC has active grassroots programs through its 10 Regional Lead Organizations (RLOs) and 2 satellite offices. They bring research and academia to the table via their association with geological surveys and engineering departments. The regional directors interact with independent oil and gas producers through technology workshops, resource centers, websites, newsletters, technical publications and other cooperative outreach efforts. PTTC's Headquarters (HQ) staff receives direction from a National Board of Directors predominantly comprised of American natural gas and oil producers to plan and manage the overall technology transfer program. PTTC HQ implements a comprehensive communications program by interconnecting the talents of the National Board, 10 Regional Producer Advisory Groups (PAG) and the RLOs with industry across the U.S. PTTC effectively combines federal funding through the Department of Energy's (DOE) Office of Fossil Energy, namely the Strategic Center for Natural Gas and Oil with state and industry contributions to share application of upstream technologies. Ultimately, these efforts factor in to provide a safe, secure and reliable energy supply for American consumers. This integrated resource base, combined with industry volunteers guiding PTTC's activities and the dedication of national and regional staff, are achieving notable results regarding domestic production figures. PTTC is increasingly recognized as a critical resource for information and access to technologies by providing direct contact with research, development and demonstration (RD&D) results. A key to the program is demonstrating proven technologies that can be applied broadly and rapidly. This technical progress report summarizes PTTC's accomplishments during

  18. Targeted Technology Transfer to US Independents

    Energy Technology Data Exchange (ETDEWEB)

    E. Lance Cole

    2009-09-30

    The Petroleum Technology Transfer Council (PTTC) was established by domestic crude oil and natural gas producers, working in conjunction with the Independent Petroleum Association of America (IPAA), the U.S. Department of Energy (DOE) and selected universities, in 1994 as a national not-for-profit organization. Its goal is to transfer Exploration and Production (E&P) technology to the domestic upstream petroleum industry, in particular to the small independent operators. PTTC connects producers, technology providers and innovators, academia, and university/industry/government research and development (R&D) groups. From inception PTTC has received federal funding through DOE's oil and natural gas program managed by the National Energy Technology Laboratory (NETL). With higher funding available in its early years, PTTC was able to deliver well more than 100 workshops per year, drawing 6,000 or more attendees per year. Facing the reality of little or no federal funding in the 2006-2007 time frame, PTTC and the American Association of Petroleum Geologists (AAPG) worked together for PTTC to become a subsidiary organization of AAPG. This change brings additional organizational and financial resources to bear for PTTC's benefit. PTTC has now been 'powered by AAPG' for two full fiscal years. There is a clear sense that PTTC has stabilized and is strengthening its regional workshop and national technology transfer programs and is becoming more entrepreneurial in exploring technology transfer opportunities beyond its primary DOE contract. Quantitative accomplishments: PTTC has maintained its unique structure of a national organization working through Regional Lead Organizations (RLOs) to deliver local, affordable workshops. During the contract period PTTC consolidated from 10 to six regions efficiency and alignment with AAPG sections. The number of workshops delivered by its RLOs during the contract period is shown below. Combined attendance over the

  19. Targeted Technology Transfer to US Independents

    Energy Technology Data Exchange (ETDEWEB)

    Schatzinger, Viola [Petroleum Tech. Transfer Council, Tulsa, OK (United States); Chapman, Kathy [Petroleum Tech. Transfer Council, Tulsa, OK (United States); Lovendahl, Kristi [Petroleum Tech. Transfer Council, Tulsa, OK (United States)

    2014-09-30

    The Petroleum Technology Transfer Council (PTTC) is a unique not-for-profit network that focuses on transferring Exploration and Production (E&P) technology to the domestic oil and natural gas producing industry. PTTC connects producers, technology providers and innovators, academia, research and development (R&D) consortiums and governments. Local affordable workshops delivered by Regional Lead Organizations (RLOs), which are typically a university or geological survey, are a primary tool. PTTC also maintains a website network, issues a national newsletter, provides a column in a major trade publication, and exhibits at major industry events. It also encourages industry to ask technology-related questions, striving to find relevant answers that will save questioners significant time. Working since late 1993, the PTTC network has a proven track record of providing industry with technology insights they can apply. Volunteers at the regional and national level provide key guidance regarding where to focus technical effort and help connect PTTC with industry. At historical funding levels, PTTC had been able to hold well more than 100 workshops per year, drawing 6,000+ attendees. As funding decreased in the early 2000s, the level of activity decreased and PTTC sought a merger with the American Association of Petroleum Geologists (AAPG), becoming an AAPG-managed organization at the start of FY08. This relationship with AAPG was terminated by mutual consent in May 2011 and PTTC once again operates independently. Chris Hall, California continued to serve as Chairman of the Board of Directors until December 2013. At the time PTTC reorganized into a RLO led organization with Mary Carr and Jeremy Viscomi as co-Executive Directors. Jerry Anderson became the Chairman of the PTTC Board of Directors and Chris Hall continues to serve on the Board. Workshop activity stabilized at 55-65 workshops per year averaging 3,100 attendees. FY14 represented the fifth year in a multi

  20. Electroless plating technology of integral hohlraum Cu target

    International Nuclear Information System (INIS)

    Liu Jiguang; Fu Qu; Wan Xiaobo; Zhou Lan; Xiao Jiang

    2005-01-01

    The electroless plating method of making integral hohlraum Cu target and corrosion-resistant technology of target's surface were researched. The actual process was as follows, choosing plexiglass (PMMA) as arbor, taking cationic activation and electroless plating Cu on the arbor surface, taking arbor surface passivation and chemical etching by C 6 H 5 N 3 solution. The technology is easy to realize and its cost is lower, so it is of great reference value for fabricating other integral hohlraum metal or alloy targets used for inertial confinement fusion study. (author)

  1. Application of SPDT technology in the field of EOS target fabrication

    International Nuclear Information System (INIS)

    Xie Jun; Huang Yanhua; Zhao Liping; Li Chaoyang; Du Kai; Tong Weichao; Yuan Guanghui; Yi Taimin; Zheng Fengcheng; Xing Pifeng

    2011-01-01

    The technology of single point diamond turning (SPDT) is capable of achieving sample surface roughness of less than 10 nm and shape accuracy of less than 100 nm, which are crucial parameters for ultra precision machining. In research of equation of state (EOS) of materials, a target must have a surface roughness of less than 50 nm, a thickness uniformity of over 98%, and a maximum peak-to-valley height of less than 200 nm, with a proximity theatrical density. A target fabricated by SPDT has the same density as the original material, with required machining precision and surface roughness. In this paper, we report some SPDT applications in laser EOS targets fabrication, which include planar-shaped, step-shaped, and wedge-shaped targets with copper or aluminum. (authors)

  2. Technology transfer from NASA to targeted industries, volume 1

    Science.gov (United States)

    Mccain, Wayne; Schroer, Bernard J.; Souder, William E.; Spann, Mary S.; Watters, Harry; Ziemke, M. Carl

    1993-01-01

    This report summarizes the University of Alabama in Huntsville (UAH) technology transfer to three target industries with focus on the apparel manufacturing industry in Alabama. Also included in this report are an analysis of the 1992 problem statements submitted by Alabama firms, the results of the survey of 1987-88 NASA Tech Brief requests, the results of the followup to Alabama submitted problem statements, and the development of the model describing the MSFC technology transfer process.

  3. Gene transfer technology and genetic radioisotope targeting therapy

    International Nuclear Information System (INIS)

    Wang Jiaqiong; Wang Zizheng

    2004-01-01

    With deeper cognition about mechanisms of disease at the cellular and molecular level, gene therapy has become one of the most important research fields in medical molecular biology at present. Gene transfer technology plays an important role during the course of gene therapy, and further improvement should be made about vectors carrying target gene sequences. Also, gene survey is needed during gene therapy, and gene imaging is the most effective method. The combination of gene therapy and targeted radiotherapy, that is, 'Genetic Radioisotope Targeting Therapy', will be a novel approach to tumor gene therapy

  4. Artificial Intelligence In Automatic Target Recognizers: Technology And Timelines

    Science.gov (United States)

    Gilmore, John F.

    1984-12-01

    The recognition of targets in thermal imagery has been a problem exhaustively analyzed in its current localized dimension. This paper discusses the application of artificial intelligence (AI) technology to automatic target recognition, a concept capable of expanding current ATR efforts into a new globalized dimension. Deficiencies of current automatic target recognition systems are reviewed in terms of system shortcomings. Areas of artificial intelligence which show the most promise in improving ATR performance are analyzed, and a timeline is formed in light of how near (as well as far) term artificial intelligence applications may exist. Current research in the area of high level expert vision systems is reviewed and the possible utilization of artificial intelligence architectures to improve low level image processing functions is also discussed. Additional application areas of relevance to solving the problem of automatic target recognition utilizing both high and low level processing are also explored.

  5. Screening Technologies for Target Identification in Pancreatic Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Michl, Patrick, E-mail: michlp@med.uni-marburg.de; Ripka, Stefanie; Gress, Thomas; Buchholz, Malte [Department of Gastroenterology and Endocrinology, University Hospital, Philipps-University Marburg, Baldinger Strasse, D-35043 Marburg (Germany)

    2010-12-29

    Pancreatic cancer exhibits an extraordinarily high level of resistance to almost any kind of systemic therapy evaluated in clinical trials so far. Therefore, the identification of novel therapeutic targets is urgently required. High-throughput screens have emerged as an important tool to identify putative targets for diagnosis and therapy in an unbiased manner. More than a decade ago, microarray technology was introduced to identify differentially expressed genes in pancreatic cancer as compared to normal pancreas, chronic pancreatitis and other cancer types located in close proximity to the pancreas. In addition, proteomic screens have facilitated the identification of differentially secreted proteins in body fluids of pancreatic cancer patients, serving as possible biomarkers. Recently, RNA interference-based loss-of-function screens have been used to identify functionally relevant genes, whose knock-down has impact on pancreatic cancer cell viability, thereby representing potential new targets for therapeutic intervention. This review summarizes recent results of transcriptional, proteomic and functional screens in pancreatic cancer and discusses potentials and limitations of the respective technologies as well as their impact on future therapeutic developments.

  6. Screening Technologies for Target Identification in Pancreatic Cancer

    International Nuclear Information System (INIS)

    Michl, Patrick; Ripka, Stefanie; Gress, Thomas; Buchholz, Malte

    2010-01-01

    Pancreatic cancer exhibits an extraordinarily high level of resistance to almost any kind of systemic therapy evaluated in clinical trials so far. Therefore, the identification of novel therapeutic targets is urgently required. High-throughput screens have emerged as an important tool to identify putative targets for diagnosis and therapy in an unbiased manner. More than a decade ago, microarray technology was introduced to identify differentially expressed genes in pancreatic cancer as compared to normal pancreas, chronic pancreatitis and other cancer types located in close proximity to the pancreas. In addition, proteomic screens have facilitated the identification of differentially secreted proteins in body fluids of pancreatic cancer patients, serving as possible biomarkers. Recently, RNA interference-based loss-of-function screens have been used to identify functionally relevant genes, whose knock-down has impact on pancreatic cancer cell viability, thereby representing potential new targets for therapeutic intervention. This review summarizes recent results of transcriptional, proteomic and functional screens in pancreatic cancer and discusses potentials and limitations of the respective technologies as well as their impact on future therapeutic developments

  7. Cyclotron targets and production technologies used for radiopharmaceuticals

    International Nuclear Information System (INIS)

    Fiser, M.; Kopicka, K.; Hradilek, P.; Hanc, P.; Lebeda, O.; Panek, J.; Vognar, M.

    2002-01-01

    Some technical aspects of development and production of cyclotron-made radiopharmaceuticals (excluding PET) are discussed. In this field, nuclear chemistry and pharmacy are in a close contact; therefore, requirements of both should be taken into account. The principles of cyclotron targetry, separation/recovery of materials and synthesis of the active substances are given, as well as issues connected with formulation pharmaceutical forms of radioactive medical products. As the radiopharmaceuticals should fulfil the requirements for in vivo preparations, there exist a variety of demands pertaining to Good Manufacturing Practice (GMP), which is also briefly discussed. A typical production chain is presented involving the treatment of irradiated cyclotron target, choosing and validation of method for pharmacon synthesis, selection or development of necessary analytical procedures, preparing active substance according pharmaceutical standards, development of dosage form, adoption of final technology procedure and opening the clinical trial. Practical examples of real technologies based on cyclotron-made radionuclides ( 81 Rb, 123 I, 68 Ge, 211 At) are given. Special attention is devoted to the technology of enriched cyclotron targets. Frequently used medicinal products employing some cyclotron-produced active substances are characterised (Rb/Kr or Ge/Ga generators, 123 I-labelled MIBG, OIH, MAB's and some others). The cyclotron produced radioactive implants for transluminal coronary angioplasty (radioactive stent) are introduced as an example of a medical device developed for therapeutic application. (author)

  8. Inertial Confinement Fusion Target Component Fabrication and Technology Development report

    International Nuclear Information System (INIS)

    Steinman, D.

    1994-03-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities which took place under this contract during the period of October 1, 1992 through September 30, 1993. During this period, GA was assigned 18 tasks in support of the Inertial Confinement Fusion program and its laboratories. These tasks included ''Capabilities Activation'' and ''Capabilities Demonstration'' to enable us to begin production of glass and composite polymer capsules. Capsule delivery tasks included ''Small Glass Shell Deliveries'' and ''Composite Polymer Capsules'' for Lawrence Livermore National Laboratory (LLNL) and Los Alamos National Laboratory (LANL). We also were asked to provide direct ''Onsite Support'' at LLNL and LANL. We continued planning for the transfer of ''Micromachining Equipment from Rocky Flats'' and established ''Target Component Micromachining and Electroplating Facilities'' at GA. We fabricated over 1100 films and filters of 11 types for Sandia National Laboratory and provided full-time onsite engineering support for target fabrication and characterization. We initiated development of methods to make targets for the Naval Research Laboratory. We investigated spherical interferometry, built an automated capsule sorter, and developed an apparatus for calorimetric measurement of fuel fill for LLNL. We assisted LANL in the ''Characterization of Opaque b-Layered Targets.'' We developed deuterated and UV-opaque polymers for use by the University of Rochester's Laboratory for Laser Energetics (UR/LLE) and devised a triple-orifice droplet generator to demonstrate the controlled-mass nature of the microencapsulation process

  9. How to trigger low carbon technologies by EU targets for 2030? An assessment of technology needs

    Energy Technology Data Exchange (ETDEWEB)

    Groenenberg, H.; Van Breevoort, P.; Janeiro, L.; Winkel, T.

    2013-04-15

    The current EU framework for energy and climate policies up to 2020 consists of three headline targets: 20% reduction of GHG emissions compared to 2005, a 20% share of renewable energy in final energy consumption, and 20% primary energy savings compared to baseline developments. While progress on these 2020 targets is mixed, discussions in the EU about climate and energy policies and targets for the period after 2020 have started. Given the long cycles associated to energy and climate investments, agreement on a clear longer-term policy framework is critical to improve visibility for investors and avoid lock-in effects in inefficient or polluting technologies. Therefore, the European Commission published a Communication on 6 June 2012 on the need for a long term policy framework for renewable energy, and a Green Paper on the 2030 climate and energy policy framework on 27 March 2013. Against this background, the Dutch Ministries of Infrastructure and Environment and the Ministry of Economic Affairs requested PBL to create input for the European debate on climate targets and policies until and beyond 2030. Ecofys supported PBL by addressing the following two questions: (1) What steps are needed for selected key technology groups to achieve long term GHG emission reductions and what climate and energy policies are likely to trigger these steps?; and (2) What are the pros and cons of a 2030 policy framework with (a) a GHG reduction target only, and (b) targets for GHG reduction, renewable energy, and energy efficiency? The focus of the first question was on four technology groups, namely (1) energy efficiency in the built environment, notably for heat; (2) solar PV and wind energy; (3) advanced biofuels; (4) CO2 carbon capture and storage (CCS). An analysis of the steps needed for the deployment of the full GHG mitigation potential of the discussed technology groups shows that this will largely depend on the adoption of a wide range of policy instruments by EU Member

  10. Expresso: A database and web server for exploring the interaction of transcription factors and their target genes inArabidopsis thalianausing ChIP-Seq peak data.

    Science.gov (United States)

    Aghamirzaie, Delasa; Raja Velmurugan, Karthik; Wu, Shuchi; Altarawy, Doaa; Heath, Lenwood S; Grene, Ruth

    2017-01-01

    Motivation: The increasing availability of chromatin immunoprecipitation sequencing (ChIP-Seq) data enables us to learn more about the action of transcription factors in the regulation of gene expression. Even though in vivo transcriptional regulation often involves the concerted action of more than one transcription factor, the format of each individual ChIP-Seq dataset usually represents the action of a single transcription factor. Therefore, a relational database in which available ChIP-Seq datasets are curated is essential. Results: We present Expresso (database and webserver) as a tool for the collection and integration of available Arabidopsis ChIP-Seq peak data, which in turn can be linked to a user's gene expression data. Known target genes of transcription factors were identified by motif analysis of publicly available GEO ChIP-Seq data sets. Expresso currently provides three services: 1) Identification of target genes of a given transcription factor; 2) Identification of transcription factors that regulate a gene of interest; 3) Computation of correlation between the gene expression of transcription factors and their target genes. Availability : Expresso is freely available at http://bioinformatics.cs.vt.edu/expresso/.

  11. Cyclotron targets and production technologies used for radiopharmaceuticals in NPI

    International Nuclear Information System (INIS)

    Fiser, M.; Kopicka, K.; Hradilek, P.; Hanc, P.; Lebeda, O.; Panek, J.; Vognar, M.

    2003-01-01

    This paper deals with some technical aspects of the development and production of cyclotron-made radiopharmaceuticals (excluding PET). In this field, nuclear chemistry and pharmacy are in a close contact; therefore, requirements of the both should be taken into account. The principles of cyclotron targetry, separation/recovery of materials and synthesis of active substances are given, as well as issues connected with formulation of pharmaceutical forms. As the radiopharmaceuticals should fulfil the requirements on in vivo preparations, there exist a variety of demands pertaining to Good Manufacturing Practice (GMP) concept, which is also briefly discussed. A typical production chain is presented and practical examples of real technologies based on cyclotron-made radionuclides are given as they have been used in Nuclear Physics Institute of CAS (NPI). Special attention is devoted to the technology of enriched cyclotron targets. Frequently used medicinal products employing cyclotron-produced active substances are characterised (Rb/Kr generators, 123 I-labelled MIBG, OIH and MAB's). The cyclotron produced radioactive implants for transluminal coronary angioplasty (radioactive stents) are introduced as an example of a medical device developed for therapeutic application. (author)

  12. A Plane Target Detection Algorithm in Remote Sensing Images based on Deep Learning Network Technology

    Science.gov (United States)

    Shuxin, Li; Zhilong, Zhang; Biao, Li

    2018-01-01

    Plane is an important target category in remote sensing targets and it is of great value to detect the plane targets automatically. As remote imaging technology developing continuously, the resolution of the remote sensing image has been very high and we can get more detailed information for detecting the remote sensing targets automatically. Deep learning network technology is the most advanced technology in image target detection and recognition, which provided great performance improvement in the field of target detection and recognition in the everyday scenes. We combined the technology with the application in the remote sensing target detection and proposed an algorithm with end to end deep network, which can learn from the remote sensing images to detect the targets in the new images automatically and robustly. Our experiments shows that the algorithm can capture the feature information of the plane target and has better performance in target detection with the old methods.

  13. Future of brain stimulation: new targets, new indications, new technology.

    Science.gov (United States)

    Hariz, Marwan; Blomstedt, Patric; Zrinzo, Ludvic

    2013-11-01

    In the last quarter of a century, DBS has become an established neurosurgical treatment for Parkinson's disease (PD), dystonia, and tremors. Improved understanding of brain circuitries and their involvement in various neurological and psychiatric illnesses, coupled with the safety of DBS and its exquisite role as a tool for ethical study of the human brain, have unlocked new opportunities for this technology, both for future therapies and in research. Serendipitous discoveries and advances in structural and functional imaging are providing abundant "new" brain targets for an ever-increasing number of pathologies, leading to investigations of DBS in diverse neurological, psychiatric, behavioral, and cognitive conditions. Trials and "proof of concept" studies of DBS are underway in pain, epilepsy, tinnitus, OCD, depression, and Gilles de la Tourette syndrome, as well as in eating disorders, addiction, cognitive decline, consciousness, and autonomic states. In parallel, ongoing technological development will provide pulse generators with longer battery longevity, segmental electrode designs allowing a current steering, and the possibility to deliver "on-demand" stimulation based on closed-loop concepts. The future of brain stimulation is certainly promising, especially for movement disorders-that will remain the main indication for DBS for the foreseeable future-and probably for some psychiatric disorders. However, brain stimulation as a technique may be at risk of gliding down a slippery slope: Some reports indicate a disturbing trend with suggestions that future DBS may be proposed for enhancement of memory in healthy people, or as a tool for "treatment" of "antisocial behavior" and for improving "morality." © 2013 International Parkinson and Movement Disorder Society.

  14. Twin Peaks

    Science.gov (United States)

    1997-01-01

    The two hills in the distance, approximately one to two kilometers away, have been dubbed the 'Twin Peaks' and are of great interest to Pathfinder scientists as objects of future study. The white areas on the left hill, called the 'Ski Run' by scientists, may have been formed by hydrologic processes.The image was taken by the Imager for Mars Pathfinder (IMP) after its deployment on Sol 3. Mars Pathfinder was developed and managed by the Jet Propulsion Laboratory (JPL) for the National Aeronautics and Space Administration. The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  15. Education, Technology, and Media: A Peak into My Summer Internship at NASA Glenn Research Center in Cleveland, Ohio

    Science.gov (United States)

    Moon, James

    2004-01-01

    My name is James Moon and I am a senor at Tennessee State University where my major is Aeronautical and Industrial Technology with a concentration in industrial electronics. I am currently serving my internship in the Engineering and Technical Services Directorate at the Glenn Research Center (GRC). The Engineering and Technical Service Directorate provides the services and infrastructure for the Glenn Research Center to take research concepts to reality. They provide a full range of integrated services including engineering, advanced prototyping and testing, facility management, and information technology for NASA, industry, and academia. Engineering and Technical Services contains the core knowledge in Information Technology (IT). This includes data systems and analysis, inter and intranet based systems design and data security. Including the design and development of embedded real-time sohare applications for flight and supporting ground systems, Engineering and Technical Services provide a wide range of IT services and products specific to the Glenn Research Center research and engineering community.

  16. Effects of peak shaving technologies in the residential and commercial sector; Minsei bumon no fuka heijunka gijutsu no donyu koka

    Energy Technology Data Exchange (ETDEWEB)

    Nagata, Y. [Kyoto University, Kyoto (Japan); Takahashi, M.; Uchiyama, Y. [Central Research Institute of Electric Power Industry, Tokyo (Japan)

    1997-09-01

    This paper analyzes how much of the power demand could be reduced in the future by improving efficiencies of electric power utilizing appliances used in the residential and commercial sector. It discusses whether the reduction would lead to load leveling. Annual load rate in the power demand is continuing to decrease because of power demand increase in the residential and commercial sector, and increase in demand for air conditioning in summer. If a technology to improve electric appliance efficiency is proliferated to its maximum scope, the annual load rate in fiscal 2014 may be improved by 1.1 percent point. Since the improvement allows new power generation facility installation cost to be deferred, the power generation unit cost can be reduced by 0.11 yen per kwh. If a heat storage type air conditioning technology is proliferated to its maximum scope, the annual load rate in fiscal 2014 can be improved by 1.8 percent point, and the power generation cost may also be reduced. If the device efficiency improving technology and the heat storage type air conditioning technology are introduced to their maximum simultaneously, the annual load rate in fiscal 2014 can be improved by 2.5 percent point, and the power generation cost may also be reduced by 0.24 yen per kwh. If a promotion policy is taken on proliferation of a specific device efficiency improving technology having excellent economic performance by providing subsidy, the reduction amount of cumulative power generation expense will be much greater than the required subsidy amount. 10 refs., 9 figs., 22 tabs.

  17. Physics and technology of superthin internal targets in storage rings

    International Nuclear Information System (INIS)

    Popov, S.G.

    1989-01-01

    The new generation of accelerators for coincidence electronuclear investigations is discussed. The luminosity and beam parameters are calculated for an electron storage ring with an internal target operating in the superthin regime. The advantages and disadvantages in comparison with conventional operation using an external beam and target are described. The intermediate results for 2 GeV electron scattering on polarized internal deuterium target are given (joint Novosibirsk-Argonne experiment). 32 refs.; 5 figs

  18. Technology strategy for subsea processing and transport; Technology Target Areas; TTA6 - Subsea processing and transportation

    Energy Technology Data Exchange (ETDEWEB)

    2008-07-01

    OG21 (www.OG21.org) Norway's official technology strategy for the petroleum sector issued a revised strategy document in November 2005 (new strategy planned in 2009). In this document 'Subsea processing and transport' was identified as one of the eight new technology target areas (TTAs). The overall OG21 strategy document is on an aggregated level, and therefore the Board of OG21 decided that a sub-strategy for each TTA was needed. This document proposes the sub-strategy for the technology target area 'Subsea processing and transport' which covers the technology and competence necessary to effectively transport well stream to a platform or to onshore facilities. This includes multiphase flow modelling, flow assurance challenges to avoid problems with hydrates, asphaltenes and wax, subsea or downhole fluid conditioning including bulk water removal, and optionally complete water removal, and sand handling. It also covers technologies to increase recovery by pressure boosting from subsea pumping and/or subsea compression. Finally it covers technologies to facilitate subsea processing such as control systems and power supply. The vision of the Subsea processing and transport TTA is: Norway is to be the leading international knowledge- and technology cluster in subsea processing and transport: Sustain increased recovery and accelerated production on the NCS by applying subsea processing and efficient transport solutions; Enable >500 km gas/condensate multiphase well stream transport; Enable >200 km oil-dominated multiphase well stream transport; Enable well stream transport of complex fluids; Enable subsea separation, boosting compression, and water injection; Enable deepwater developments; Enable environmentally friendly and energy efficient field development. Increase the export of subsea processing and transport technology: Optimize technology from the NCS for application worldwide; Develop new technology that can meet the challenges found in

  19. Multi-Sensor CSEM Technology for Buried Target Classification

    Science.gov (United States)

    2006-04-24

    Department of Geology and Geophysics Cam Nguyen Department of Electrical and Computer Engineering Texas A&M University College Station, TX 77843...Target Classification Mark E. Everett Department of Geology and Geophysics Cam Nguyen Department of Electrical and Computer Engineering Texas...and Nguyen, C 2003. Fractal properties of background noise and target signal enhancement using CSEM data, Proc. SPIE 5089: Detection and Remediation

  20. Energy technologies for post Kyoto targets in the medium term

    International Nuclear Information System (INIS)

    Soenderberg Petersen, L.; Larsen, H.

    2003-09-01

    The Risoe International Energy Conference took place 19 - 21 May 2003 and the aim was to present and discuss new developments and trends in energy technologies which may become main contributors to the energy scene in 15 to 20 years. The conference addressed R and D related to the individual technologies as well as system integration. The proceedings are prepared from papers presented at the conference and received with corrections, if any, until the final deadline on 25 June 2003. (au)

  1. Energy technologies for post Kyoto targets in the medium term

    Energy Technology Data Exchange (ETDEWEB)

    Soenderberg Petersen, L.; Larsen, H. (eds.)

    2003-09-01

    The Risoe International Energy Conference took place 19 - 21 May 2003 and the aim was to present and discuss new developments and trends in energy technologies which may become main contributors to the energy scene in 15 to 20 years. The conference addressed R&D related to the individual technologies as well as system integration. The proceedings are prepared from papers presented at the conference and received with corrections, if any, until the final deadline on 25 June 2003. (au)

  2. Technology transfer from NASA to targeted industries, volume 2

    Science.gov (United States)

    Mccain, Wayne; Schroer, Bernard J.; Souder, William E.; Spann, Mary S.; Watters, Harry; Ziemke, M. Carl

    1993-01-01

    This volume contains the following materials to support Volume 1: (1) Survey of Metal Fabrication Industry in Alabama; (2) Survey of Electronics Manufacturing/Assembly Industry in Alabama; (3) Apparel Modular Manufacturing Simulators; (4) Synopsis of a Stereolithography Project; (5) Transferring Modular Manufacturing Technology to an Apparel Firm; (6) Letters of Support; (7) Fact Sheets; (8) Publications; and (9) One Stop Access to NASA Technology Brochure.

  3. Gene targeting in embryonic stem cells, II: conditional technologies

    Science.gov (United States)

    Genome modification via transgenesis has allowed researchers to link genotype and phenotype as an alternative approach to the characterization of random mutations through evolution. The synergy of technologies from the fields of embryonic stem (ES) cells, gene knockouts, and protein-mediated recombi...

  4. Addressing key science and technology issues for IFE chambers, target fabrication and target injection

    International Nuclear Information System (INIS)

    Meier, W.R.; Goodin, D.T.; Nobile, A.

    2003-01-01

    Significant progress has been made in the development of high repetition rate chambers, target fabrication and injection for inertial fusion energy (IFE) for both heavy ion and laser drivers. Research is being conducted in a coordinated manner by national laboratories, universities and industry. This paper provides an overview of U.S. research activities and discusses how interface considerations (such as beam propagation and target survival during injection) impact design choices. (author)

  5. Near-term technology policies for long-term climate targets--economy wide versus technology specific approaches

    International Nuclear Information System (INIS)

    Sanden, B.A.; Azar, Christian

    2005-01-01

    The aim of this paper is to offer suggestions when it comes to near-term technology policies for long-term climate targets based on some insights into the nature of technical change. We make a distinction between economy wide and technology specific policy instruments and put forward two key hypotheses: (i) Near-term carbon targets such as the Kyoto protocol can be met by economy wide price instruments (carbon taxes, or a cap-and-trade system) changing the technologies we pick from the shelf (higher energy efficiency in cars, buildings and industry, wind, biomass for heat and electricity, natural gas instead of coal, solar thermal, etc.). (ii) Technology specific policies are needed to bring new technologies to the shelf. Without these new technologies, stricter emission reduction targets may be considered impossible to meet by the government, industry and the general public, and therefore not adopted. The policies required to bring these more advanced technologies to the shelf are more complex and include increased public research and development, demonstration, niche market creation, support for networks within the new industries, standard settings and infrastructure policies (e.g., when it comes to hydrogen distribution). There is a risk that the society in its quest for cost-efficiency in meeting near-term emissions targets, becomes blindfolded when it comes to the more difficult, but equally important issue of bringing more advanced technologies to the shelf. The paper presents mechanisms that cause technology look in, how these very mechanisms can be used to get out of the current 'carbon lock-in' and the risk with premature lock-ins into new technologies that do not deliver what they currently promise. We then review certain climate policy proposals with regards to their expected technology impact, and finally we present a let-a-hundred-flowers-bloom strategy for the next couple of decades

  6. FY05 Targeted Technology Transfer to US Independents

    Energy Technology Data Exchange (ETDEWEB)

    Donald F. Duttlinger; E. Lance Cole

    2005-11-01

    Petroleum Technology Transfer Council (PTTC) was established by domestic crude oil and natural gas producers in 1994 as a national not-for-profit organization to address the increasingly urgent need to improve the technology-transfer process in the U.S. upstream petroleum industry. PTTC's technology-transfer programs enhance U.S. national security. PTTC administers the only nation-wide, comprehensive program dedicated to maximizing America's supplies of domestic oil and gas. PTTC conducts grassroots programs through 10 Regional Lead Organizations (RLOs) and two satellite offices, leveraging their preexisting connections with industry. This organizational structure helps bring researchers and academia to the table. Nationally and regionally, volunteers within a National Board and Regional Producer Advisory Groups guide efforts. The National Board meets three times per year, an important function being approving the annual plans and budgets developed by the regions and Headquarters (HQ). Between Board meetings, an active Management and Budget Committee guide HQ activity. PTTC itself undergoes a thorough financial audit each year. The PTTC's HQ staff plans and manages all aspects of the PTTC program, conducts nation-wide technology-transfer activities, and implements a comprehensive communications program. Networking, involvement in technical activities, and an active exhibit schedule are increasing PTTC's sphere of influence with both producers and the oilfield service sector. Circulation for ''PTTC Network News'', the quarterly newsletter, has risen to nearly 17,500. About 7,500 people receive an email Technology Alert on an approximate three-week frequency. Case studies in the ''Petroleum Technology Digest in World Oil'' appear monthly, as do ''Tech Connections'' columns in ''The American Oil and Gas Reporter''. As part of its oversight responsibility for the regions

  7. CRISPR/Cas9 technology for targeted genome editing

    Directory of Open Access Journals (Sweden)

    Lomov N. A.

    2015-08-01

    Full Text Available CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats are the segments of prokaryotic DNA containing short repeats in its nucleotide sequence. Today we know that this is a bacterial protection system against viral DNA. The molecular components of CRISPR/Cas9 system have been used for a gene editing in eukaryotes since 2013. But as any other method it also has the limitations and drawbacks. Here we are going to review the history of CRISPR biology and to discuss the possibilities that this new technology provides to researchers as well as the prospects for its use in the medical research and treatment.

  8. Rethinking the oilsands : new technologies target fuel use, upgrading efficiencies

    International Nuclear Information System (INIS)

    Stonehouse, D.; Ball, C.; Proce, B.

    2005-01-01

    The Oil Sands Technology Roadmap has plans for the industry to produce 5 million barrels a day of bitumen production by 2030. The volume is in line with the size of the reserve of 175 billion barrels of recoverable oil using known technology. Currently the industry produces 1 million barrels per day and is prepared to raise production to 2 million barrels per day by 2012. However, while thermal recovery technologies open up more of the oil sands for production, they also come with the added cost of fuel for steam generation. Much of the research in the oilsands sector is focused on finding alternative fuels for power and steam and alternate sources of hydrogen for upgrading. A number of upgrading challenges were identified in the roadmap, such as reducing costs, improving the quality of synthetic crude and reducing the increasingly unsustainable use of natural gas consumption for both recovery and upgrading. Upgrading processes were reviewed in this article, with details of coking procedures, primary and secondary upgrading, as well as synthetic crude fractions and refining difficulties. Plans to use oil sands residues as an alternate energy source were discussed, in relation to the advantages of hydro-cracking and higher quality distillates. Details of a project using this procedure at the Nexen/OPTI Long Lake Project were presented. The project is designed to produce its own electricity and fuel, resulting in significant operating cost reductions. Suncor is also currently looking at gasification of by-products. Deer Creek's Joslyn oilsands project is currently testing Multi-Phase Superfine Atomized Residue (MSAR), which is a fuel designed to replace natural gas and is comprised of 70 per cent bitumen and 30 per cent water, with trace amounts of surfactants. Quadrise Canada Fuel Systems owns the rights to the new technology. MSAR is currently much cheaper than natural gas and there is an endless supply. It was suggested that delays in the Mackenzie Valley Pipeline

  9. Report of the consultants' meeting on target and processing technologies for cyclotron production of radionuclides

    International Nuclear Information System (INIS)

    1999-11-01

    Cyclotron produced radionuclides are used routinely for the diagnosis of a wide variety of diseases. Recently a number of radionuclides available from cyclotrons have been proposed for use in radiotherapy. In fact Pd-103 has become routinely available in some parts of the world for incorporation into brachytherapy seeds for treating prostate cancer. The consultants meeting reviewed the status of target and processing technologies associated with cyclotron production of radionuclides. The main topics of discussion included the basic nuclear data that is crucial to the production of the desired radionuclides, gas and solid target systems, the automated chemical processing units, the Good Manufacturing Practices (GMP) required in order to use these radionuclides in human patients in a safe and efficacious manner and a review of possible candidate nuclides that show promise for use in Nuclear Medicine in the near future. Advances in the preparation of solid targets using electroplating technology has created the possibility of preparing targets capable of operating at very high beam currents which would make the production of large quantities of SPECT agents possible at cyclotron facilities throughout the world. Recognising the needs of the developing countries which have established cyclotron facilities, the consultants focussed on how to provide the technology for preparing solid targets that could be used in the existing facilities. While solid target technology can be used for many radionuclides the report concentrated on several key radionuclides, which are of current importance or show potential for use in the near future. Tl-201 is currently used for cardiac profusion studies throughout the world. New target preparation techniques could potentially make many of the member states self sufficient in the production of this nuclide. I-123 has tremendous potential because of the near ideal photon energy for SPECT cameras and its well-understood chemistry. However, it

  10. Technologies for ITER divertor vertical target plasma facing components

    International Nuclear Information System (INIS)

    Schlosser, J.; Escourbiac, F.; Merola, M.; Fouquet, S.; Bayetti, P.; Cordier, J.J.; Grosman, A.; Missirlian, M.; Tivey, R.; Roedig, M.

    2005-01-01

    The ITER divertor vertical target has to sustain heat fluxes up to 20 MW m -2 . The concept developed for this plasma facing component working at steady state is based on carbon fibre composite armour for the lower straight part and tungsten for the curved upper part. The main challenges involved in the use of such components include the removal of the high heat fluxes deposited and mechanically and thermally joining the armour to the metallic heat sink, despite the mismatch in the thermal expansions. Two solutions based on the use of a CuCrZr hardened copper alloy and an active metal casting (AMC (registered) ) process were investigated during the ITER EDA phase: the first one called 'flat tile geometry' was mainly developed for the Tore Supra pumped limiter, the second one called 'monoblock geometry' was developed by the EU Participating Team for the ITER project. This paper presents a review of these two solutions and analyses their assets and drawbacks: pressure drop, critical heat flux, surface temperature and expected behaviour during operation, risks during the manufacture, control of the armour defects during the manufacture and at the reception, and the possibility of repairing defective tiles

  11. Energy technologies evaluated against climate targets using a cost and carbon trade-off curve.

    Science.gov (United States)

    Trancik, Jessika E; Cross-Call, Daniel

    2013-06-18

    Over the next few decades, severe cuts in emissions from energy will be required to meet global climate-change mitigation goals. These emission reductions imply a major shift toward low-carbon energy technologies, and the economic cost and technical feasibility of mitigation are therefore highly dependent upon the future performance of energy technologies. However, existing models do not readily translate into quantitative targets against which we can judge the dynamic performance of technologies. Here, we present a simple, new model for evaluating energy-supply technologies and their improvement trajectories against climate-change mitigation goals. We define a target for technology performance in terms of the carbon intensity of energy, consistent with emission reduction goals, and show how the target depends upon energy demand levels. Because the cost of energy determines the level of adoption, we then compare supply technologies to one another and to this target based on their position on a cost and carbon trade-off curve and how the position changes over time. Applying the model to U.S. electricity, we show that the target for carbon intensity will approach zero by midcentury for commonly cited emission reduction goals, even under a high demand-side efficiency scenario. For Chinese electricity, the carbon intensity target is relaxed and less certain because of lesser emission reductions and greater variability in energy demand projections. Examining a century-long database on changes in the cost-carbon space, we find that the magnitude of changes in cost and carbon intensity that are required to meet future performance targets is not unprecedented, providing some evidence that these targets are within engineering reach. The cost and carbon trade-off curve can be used to evaluate the dynamic performance of existing and new technologies against climate-change mitigation goals.

  12. Targeted pricing, consumer myopia and investment in customer-tracking technology

    OpenAIRE

    Baye, Irina; Sapi, Geza

    2014-01-01

    We analyze how consumer myopia influences investment incentives into a technology that enables firms to track consumers' purchases and make targeted offers based on their preferences. In a two-period Hotelling setup firms may invest in customer-tracking technology. If a firm acquires the technology, it can practice first-degree price discrimination among consumers that bought from it in the first period. We distinguish between the cases of all consumers being myopic and when they are sophisti...

  13. Optimisation of high-performance liquid chromatography with diode array detection using an automatic peak tracking procedure based on augmented iterative target transformation factor analysis

    NARCIS (Netherlands)

    van Zomeren, Paul; Hoogvorst, A.; Coenegracht, P.M J; de Jong, G.J.

    2004-01-01

    An automated method for the optimisation of high-performance liquid chromatography is developed. First of all, the sample of interest is analysed with various eluent compositions. All obtained data are combined into one augmented data matrix. Subsequently, augmented iterative target transformation

  14. Biofuels development in China: Technology options and policies needed to meet the 2020 target

    International Nuclear Information System (INIS)

    Chang, Shiyan; Zhao, Lili; Timilsina, Govinda R.; Zhang, Xiliang

    2012-01-01

    China promulgated the Medium and Long-Term Development Plan for Renewable Energy in 2007, which included sub-targets of 2010 and 2020 for various renewable energy technologies. Almost all the 2010 sub-targets have been met and even surpassed except non-grain fuel ethanol. There is debate surrounding the questions of whether and how the country will be able to meet the 2020 biofuels target. This paper provides the assessment of potential technology pathways to achieve the 2020 target regarding their respective resource potential and supply cost. Barriers and policy options are identified based on broad literatures review. And an overview of biofuels projections is presented to provide insight into the comparison of various policy scenarios. The study shows that China can potentially satisfy non-grain fuel ethanol target by 2020 from technology perspective. But she will probably fall far short of this target if current situations continue. Additional policy efforts are needed. Meanwhile, the target of biodiesel production has high probability to be achieved. However, if given support policies, it will develop better. - Highlights: ► I. Non-grain feedstocks such as cassava, sweet sorghum and sweet potato grown in low productive arable lands or unutilized lands have enough potential to meet ethanol targets in 2020. ► II. If current situations continue, China will fall far short of the 2020 target. ► III. The target of biodiesel production has high probability to be achieved, while, if given support policies, it will develop better. ► IV. Supply cost is one of the major barriers faced by all biofuels pathways. ► V. Various policy measures would be necessary to overcome the costs barriers to biofuels in China.

  15. Technology of target positioning precision measurement of high power laser system

    International Nuclear Information System (INIS)

    Sun Zhihong; Li Ping; Zhao Runchang; Li Zhijun; Liu Hua; Xia Yanwen

    2011-01-01

    The target positioning precision of multi-beam laser facility is crucial to future inertial confinement fusion experiments, so the calculation methods have been developed for estimating the target positioning precision. The measurement method of target positioning precision based on the X-ray pinhole camera was presented. The coordinates of target center position determined by microscope and read by X-ray pinhole camera after the shoot on CH target of multi-hole, the conversion relationship of coordinates between target plane and X-ray pinhole camera was established. The template of focal area was acquired after the shoot of focal area target. The match method of template was adopted, and the position coordinates of focal area center were obtained by X-ray pinhole camera. The position of focal area center in the target plane coordinates can be calculated through the conversion of coordinates, and then the target positioning precision measurement of the laser system can be calculated. The measurement technology and methods of target positioning precision of multi-beam laser facility are presented, and the uncertainty is analyzed, consequently. (authors)

  16. Integration of multidisciplinary technologies for real time target visualization and verification for radiotherapy

    Directory of Open Access Journals (Sweden)

    Chang WC

    2014-06-01

    Full Text Available Wen-Chung Chang,1,* Chin-Sheng Chen,2,* Hung-Chi Tai,3 Chia-Yuan Liu,4,5 Yu-Jen Chen3 1Department of Electrical Engineering, National Taipei University of Technology, Taipei, Taiwan; 2Graduate Institute of Automation Technology, National Taipei University of Technology, Taipei, Taiwan; 3Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan; 4Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan; 5Department of Medicine, Mackay Medical College, New Taipei City, Taiwan  *These authors contributed equally to this work Abstract: The current practice of radiotherapy examines target coverage solely from digitally reconstructed beam's eye view (BEV in a way that is indirectly accessible and that is not in real time. We aimed to visualize treatment targets in real time from each BEV. The image data of phantom or patients from ultrasound (US and computed tomography (CT scans were captured to perform image registration. We integrated US, CT, US/CT image registration, robotic manipulation of US, a radiation treatment planning system, and a linear accelerator to constitute an innovative target visualization system. The performance of this algorithm segmented the target organ in CT images, transformed and reconstructed US images to match each orientation, and generated image registration in real time mode with acceptable accuracy. This image transformation allowed physicians to visualize the CT image-reconstructed target via a US probe outside the BEV that was non-coplanar to the beam's plane. It allowed the physicians to remotely control the US probe that was equipped on a robotic arm to dynamically trace and real time monitor the coverage of the target within the BEV during a simulated beam-on situation. This target visualization system may provide a direct remotely accessible and real time way to visualize, verify, and ensure tumor targeting during radiotherapy. Keywords: ultrasound, computerized tomography

  17. Modern gas-target technology for the production of high quality radiopharmaceuticals

    International Nuclear Information System (INIS)

    Bechtold, V.; Kernert, N.

    1992-01-01

    The Karlsruhe isotope production facility consists of a compact H - -cyclotron and several sophisticated target stations. The cyclotron is variable in energy between 15 MeV and 42 MeV. Extracted currents up to 120 μA can be produced reliably. This facility is dedicated to the production of isotopes for medical applications. Routine production of radioisotopes places high demands on target technology and chemistry, with regards to reliability, production efficiency and quality. The following topics will be discussed: automation, material problems and radiation damage in the target area, target window, cooling problems, safety philosophy, chemistry and quality control. Examples of targets for the production of I-123, Rb-81 and the Rb-81/Kr-81m generator system will be presented. (author)

  18. A novel technology to target adenovirus vectors : application in cells involved in atherosclerosis

    NARCIS (Netherlands)

    Gras, Jan Cornelis Emile

    2007-01-01

    In this thesis a novel technology is described to target adenovirus vectors. Adenovirus vectors are powerful tools to modulate gene expression. The use of these vectors however, is hampered by the fact that many for gene therapy interesting cell types do not, or only at low levels express the CAR

  19. Method for Targeted Therapeutic Delivery of Proteins into Cells | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The Protein Expression Laboratory at the National Cancer Institute in Frederick, MD is seeking statements of capability or interest from parties interested in collaborative research to further develop a platform technology for the targeted intra-cellular delivery of proteins using virus-like particles (VLPs).

  20. Chemical Genomics and Emerging DNA Technologies in the Identification of Drug Mechanisms and Drug Targets

    DEFF Research Database (Denmark)

    Olsen, Louise Cathrine Braun; Færgeman, Nils J.

    2012-01-01

    and validate therapeutic targets and to discover drug candidates for rapidly and effectively generating new interventions for human diseases. The recent emergence of genomic technologies and their application on genetically tractable model organisms like Drosophila melanogaster,Caenorhabditis elegans...... critical roles in the genomic age of biological research and drug discovery. In the present review we discuss how simple biological model organisms can be used as screening platforms in combination with emerging genomic technologies to advance the identification of potential drugs and their molecular...... and Saccharomyces cerevisiae have provided momentum to cell biological and biomedical research, particularly in the functional characterization of gene functions and the identification of novel drug targets. We therefore anticipate that chemical genomics and the vast development of genomic technologies will play...

  1. Target and (Astro-)WISE technologies Data federations and its applications

    Science.gov (United States)

    Valentijn, E. A.; Begeman, K.; Belikov, A.; Boxhoorn, D. R.; Brinchmann, J.; McFarland, J.; Holties, H.; Kuijken, K. H.; Kleijn, G. Verdoes; Vriend, W.-J.; Williams, O. R.; Roerdink, J. B. T. M.; Schomaker, L. R. B.; Swertz, M. A.; Tsyganov, A.; van Dijk, G. J. W.

    2017-06-01

    After its first implementation in 2003 the Astro-WISE technology has been rolled out in several European countries and is used for the production of the KiDS survey data. In the multi-disciplinary Target initiative this technology, nicknamed WISE technology, has been further applied to a large number of projects. Here, we highlight the data handling of other astronomical applications, such as VLT-MUSE and LOFAR, together with some non-astronomical applications such as the medical projects Lifelines and GLIMPS; the MONK handwritten text recognition system; and business applications, by amongst others, the Target Holding. We describe some of the most important lessons learned and describe the application of the data-centric WISE type of approach to the Science Ground Segment of the Euclid satellite.

  2. The development of uranium foil farication technology utilizing twin roll method for Mo-99 irradiation target

    CERN Document Server

    Kim, C K; Park, H D

    2002-01-01

    MDS Nordion in Canada, occupying about 75% of global supply of Mo-99 isotope, has provided the irradiation target of Mo-99 using the rod-type UAl sub x alloys with HEU(High Enrichment Uranium). ANL (Argonne National Laboratory) through co-operation with BATAN in Indonesia, leading RERTR (Reduced Enrichment for Research and Test Reactors) program substantially for nuclear non-proliferation, has designed and fabricated the annular cylinder of uranium targets, and successfully performed irradiation test, in order to develop the fabrication technology of fission Mo-99 using LEU(Low Enrichment Uranium). As the uranium foils could be fabricated in laboratory scale, not in commercialized scale by hot rolling method due to significant problems in foil quality, productivity and economic efficiency, attention has shifted to the development of new technology. Under these circumstances, the invention of uranium foil fabrication technology utilizing twin-roll casting method in KAERI is found to be able to fabricate LEU or...

  3. Chemical Genomics and Emerging DNA Technologies in the Identification of Drug Mechanisms and Drug Targets

    DEFF Research Database (Denmark)

    Olsen, Louise Cathrine Braun; Færgeman, Nils J.

    2012-01-01

    and validate therapeutic targets and to discover drug candidates for rapidly and effectively generating new interventions for human diseases. The recent emergence of genomic technologies and their application on genetically tractable model organisms like Drosophila melanogaster,Caenorhabditis elegans...... and Saccharomyces cerevisiae have provided momentum to cell biological and biomedical research, particularly in the functional characterization of gene functions and the identification of novel drug targets. We therefore anticipate that chemical genomics and the vast development of genomic technologies will play...... critical roles in the genomic age of biological research and drug discovery. In the present review we discuss how simple biological model organisms can be used as screening platforms in combination with emerging genomic technologies to advance the identification of potential drugs and their molecular...

  4. The concept of multiple-target anti-miRNA antisense oligonucleotide technology.

    Science.gov (United States)

    Wang, Zhiguo

    2011-01-01

    The multiple-target AMO technology or MT-AMO technology is an innovative strategy, which confers on a single AMO fragment the capability of targeting multiple miRNAs. This modified AMO is single-stranded 2'-O-methyl-modified oligoribonucleotides carrying multiple AMO units, which are engineered into a single unit and are able to simultaneously silence multiple-target miRNAs or multiple miRNA seed families. Studies suggest that the MT-AMO is an improved approach for miRNA target finding and miRNA function validation; it not only enhances the effectiveness of targeting miRNAs but also confers diversity of actions. It has been successfully used to identify target genes and cellular function of several oncogenic miRNAs and of the muscle-specific miRNAs (Lu et al., Nucleic Acids Res 37:e24-e33, 2009). This novel strategy may find its broad application as a useful tool in miRNA research for exploring biological processes involving multiple miRNAs and multiple genes, and the potential as an miRNA therapy for human disease such as cancer and cardiac disorders. This technology was developed by my research laboratory in collaboration with Yang's group (Lu et al., Nucleic Acids Res 37:e24-e33, 2009), and it is similar but distinct from the miRNA Sponge technology developed by Sharp's laboratory in 2007 (Ebert et al., Nat Methods 4:721-726, 2007) and modified by Gentner et al. (Nat Methods 6:63-66, 2009).

  5. Technology strategy for enhanced recovery; Technology Target Areas; TTA3 - enhanced recovery

    Energy Technology Data Exchange (ETDEWEB)

    2007-07-01

    The Norwegian Continental Shelf (NCS) is facing new challenges in reserve replacement and improved recovery in order to maintain the overall oil production rate from the area. A new target for an increase in oil reserves of 800 million Sm3 of oil (5 billion barrels) by year 2015 has been set by NPD. This is an ambitious goal considering several of the large fields are on a steep decline, and most of the recent discoveries are relatively small. A significant part of these increased reserves will have to come from fields currently on production, from reservoir areas that have been partly or fully swept, and it is therefore evident that Enhanced Oil Recovery (EOR) methods have to play a key role in achieving this target. EOR methods can be divided into gas based EOR methods and water based EOR methods. Thermal methods are not considered applicable on the NCS due to the relatively light oils present, and the depth of the reservoirs. Gas Based EOR; Water Based EOR; CO{sub 2} injection; Surfactants; Air injection; Polymer; Nitrogen injection; Alkaline; Flue gas injection; Polymer gels; WAG; MEOR; FAWAG. The former OG21 strategy document gave high priority to Water Alternating Gas (WAG) methods and CO{sub 2} injection for enhanced recovery. A lot of research and development and evaluation projects on CO{sub 2} injection were launched and are on-going, most of these are being CO{sub 2} WAG studies. The main challenge now in order to realize CO{sub 2} injection on the NCS is on CO{sub 2} availability and transport. It is also believed that increasing gas prices will limit the availability of hydrocarbon gas for injection purposes in the future. There is, however, a clear need for developing alternative cost efficient EOR methods that can improve the sweep efficiency significantly. Since a majority of the fields on the NCS are being produced under water flooding (or WAG), methods that can improve the water flooding efficiency by chemical additives are of special interest and

  6. Fermilab Project X nuclear energy application: Accelerator, spallation target and transmutation technology demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Gohar, Yousry; /Argonne; Johnson, David; Johnson, Todd; Mishra, Shekhar; /Fermilab

    2011-04-01

    The recent paper 'Accelerator and Target Technology for Accelerator Driven Transmutation and Energy Production' and report 'Accelerators for America's Future' have endorsed the idea that the next generation particle accelerators would enable technological breakthrough needed for nuclear energy applications, including transmutation of waste. In the Fall of 2009 Fermilab sponsored a workshop on Application of High Intensity Proton Accelerators to explore in detail the use of the Superconducting Radio Frequency (SRF) accelerator technology for Nuclear Energy Applications. High intensity Continuous Wave (CW) beam from the Superconducting Radio Frequency (SRF) Linac (Project-X) at beam energy between 1-2 GeV will provide an unprecedented experimental and demonstration facility in the United States for much needed nuclear energy Research and Development. We propose to carry out an experimental program to demonstrate the reliability of the accelerator technology, Lead-Bismuth spallation target technology and a transmutation experiment of spent nuclear fuel. We also suggest that this facility could be used for other Nuclear Energy applications.

  7. Evaluating the Development of Biocatalytic Technology for the Targeted Removal of Perchlorate from Drinking Water.

    Science.gov (United States)

    Hutchison, Justin M; Guest, Jeremy S; Zilles, Julie L

    2017-06-20

    Removing micropollutants is challenging in part because of their toxicity at low concentrations. A biocatalytic approach could harness the high affinity of enzymes for their substrates to address this challenge. The potential of biocatalysis relative to mature (nonselective ion exchange, selective ion exchange, and whole-cell biological reduction) and emerging (catalysis) perchlorate-removal technologies was evaluated through a quantitative sustainable design framework, and research objectives were prioritized to advance economic and environmental sustainability. In its current undeveloped state, the biocatalytic technology was approximately 1 order of magnitude higher in cost and environmental impact than nonselective ion exchange. Biocatalyst production was highly correlated with cost and impact. Realistic improvement scenarios targeting biocatalyst yield, biocatalyst immobilization for reuse, and elimination of an electron shuttle could reduce total costs to $0.034 m -3 and global warming potential (GWP) to 0.051 kg CO 2 eq m -3 : roughly 6.5% of cost and 7.3% of GWP of the background from drinking water treatment and competitive with the best performing technology, selective ion exchange. With less stringent perchlorate regulatory limits, ion exchange technologies had increased cost and impact, in contrast to biocatalytic and catalytic technologies. Targeted advances in biocatalysis could provide affordable and sustainable treatment options to protect the public from micropollutants.

  8. Advances in clinical next-generation sequencing: target enrichment and sequencing technologies.

    Science.gov (United States)

    Ballester, Leomar Y; Luthra, Rajyalakshmi; Kanagal-Shamanna, Rashmi; Singh, Rajesh R

    2016-01-01

    The huge parallel sequencing capabilities of next generation sequencing technologies have made them the tools of choice to characterize genomic aberrations for research and diagnostic purposes. For clinical applications, screening the whole genome or exome is challenging owing to the large genomic area to be sequenced, associated costs, complexity of data, and lack of known clinical significance of all genes. Consequently, routine screening involves limited markers with established clinical relevance. This process, referred to as targeted genome sequencing, requires selective enrichment of the genomic areas comprising these markers via one of several primer or probe-based enrichment strategies, followed by sequencing of the enriched genomic areas. Here, the authors review current target enrichment approaches and next generation sequencing platforms, focusing on the underlying principles, capabilities, and limitations of each technology along with validation and implementation for clinical testing.

  9. Peak flow meter (image)

    Science.gov (United States)

    A peak flow meter is commonly used by a person with asthma to measure the amount of air that can be ... become narrow or blocked due to asthma, peak flow values will drop because the person cannot blow ...

  10. Sunset over Twin Peaks

    Science.gov (United States)

    1997-01-01

    This image was taken by the Imager for Mars Pathfinder (IMP) about one minute after sunset on Mars on Sol 21. The prominent hills dubbed 'Twin Peaks' form a dark silhouette at the horizon, while the setting sun casts a pink glow over the darkening sky. The image was taken as part of a twilight study which indicates how the brightness of the sky fades with time after sunset. Scientists found that the sky stays bright for up to two hours after sunset, indicating that Martian dust extends very high into the atmosphere.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  11. Decision Analysis and Policy Formulation for Technology-Specific Renewable Energy Targets

    Science.gov (United States)

    Okioga, Irene Teshamulwa

    This study establishes a decision making procedure using Analytic Hierarchy Process (AHP) for a U.S. national renewable portfolio standard, and proposes technology-specific targets for renewable electricity generation for the country. The study prioritizes renewable energy alternatives based on a multi-perspective view: from the public, policy makers, and investors' points-of-view, and uses multiple criteria for ranking the alternatives to generate a unified prioritization scheme. During this process, it considers a 'quadruple bottom-line' approach (4P), i.e. reflecting technical "progress", social "people", economic 'profits", and environmental "planet" factors. The AHP results indicated that electricity generation from solar PV ranked highest, and biomass energy ranked lowest. A "Benefits/Cost Incentives/Mandates" (BCIM) model was developed to identify where mandates are needed, and where incentives would instead be required to bring down costs for technologies that have potential for profitable deployment. The BCIM model balances the development of less mature renewable energy technologies, without the potential for rising near-term electricity rates for consumers. It also ensures that recommended policies do not lead to growth of just one type of technology--the "highest-benefit, least-cost" technology. The model indicated that mandates would be suited for solar PV, and incentives generally for geothermal and concentrated solar power. Development for biomass energy, as a "low-cost, low-benefits" alternative was recommended at a local rather than national level, mainly due to its low resource potential values. Further, biomass energy generated from wastewater treatment plants (WWTPs) had the least resource potential compared to other biomass sources. The research developed methodologies and recommendations for biogas electricity targets at WWTPs, to take advantage of the waste-to-energy opportunities.

  12. Physics and technology of inertial fusion energy targets chambers and drivers. Proceedings of a technical meeting

    International Nuclear Information System (INIS)

    2005-09-01

    The third IAEA Technical Meeting on Physics and Technology of Inertial Fusion Energy Targets and Chambers took place 11-13 October 2004 in the Yousung Hotel Daejon, Republic of Korea. The first meeting was held in Madrid, Spain, 7-9 June 2000, and the second one in San Diego, California, 17-19 June 2002. Nuclear fusion has the promise of becoming an abundant energy source with good environmental compatibility. Excellent progress has been made in controlled nuclear fusion research on both magnetic and inertial approaches for plasma confinement. The IAEA plays a pro-active role to catalyze innovation and enhance worldwide commitment to fusion. This is done by creating awareness of the different concepts of magnetic as well as inertial confinement. The International Fusion Research Council (IFRC) supports the IAEA in the development of strategies to enhance fusion research in Member States. As part of the recommendations, a technical meeting on the physics and technology of inertial fusion energy (IFE) was proposed in one of the council meetings. The objective of the technical meeting was to contribute to advancing the understanding of targets and chambers for all proposed inertial fusion energy power plant designs. The topics to be covered were: Target design and physics, chamber design and physics, target fabrication injection and Tritium handling, assessment of safety, environment and economy aspect of IFE. It was recognized by the International Advisory Committee that the scope of the meeting should also include fusion drivers. The presentations of the meeting included target and chamber physics and technology for all proposed IFE plant concepts (laser driven, heavy-ion driven, Z-pinches, etc.). The final Research Coordination Meeting of the Coordinated Research Project on Elements of Power Plant Design for Inertial Fusion Energy, including further new results and achievements, followed the technical meeting. Twenty-nine participants from 12 countries participated

  13. TARGETED RESEARCH AND TECHNOLOGY WITHIN NASA'S LIVING WITH A STAR PROGRAM.

    Energy Technology Data Exchange (ETDEWEB)

    Gosling, J. T.; Antiochos, Spiro; Baker, Kile; Bellaire, Paul; Blake, Bern; Crowley, Geoff; Eddy, Jack; Goodrich, Charles; Gopalswamy, Nat; Hesse, Michael; Hurlburt, Neal; Jackman, Charles; Kozyra, Janet; Labonte, Barry; Lean, Judith; Linker, Jon; Mazur, Joe; Onsager, Terry; Sibeck, David

    2003-07-10

    NASA’s Living With a Star (LWS) initiative is a systematic, goal-oriented research program targeting those aspects of the Sun-Earth system that affect society. The Targeted Research and Technology (TR&T) component of LWS provides the theory, modeling, and data analysis necessary to enable an integrated, system-wide picture of Sun-Earth connection science with societal relevance. Recognizing the central and essential role that TR&T would have for the success of the LWS initiative, the LWS Science Architecture Team (SAT) recommended that a Science Definition Team (SDT), with the same status as a flight mission definition team, be formed to design and coordinate a TR&T program having prioritized goals and objectives that focused on practical societal benefits. This report details the SDT recommendations for the TR&T program.

  14. Development of technology for producing nickel-gallium cyclotron targets by galvanic methods

    International Nuclear Information System (INIS)

    Umerov, R.A.; Kim, A.A.; Tushakov, S.A.; Djuraeva, G.T.; Khudaybergenov, U.; Tahirova, M.N.; Uzakov, Ya.M.

    2006-01-01

    Full text: At present radioactive nuclides and their radioactive preparations are widely applied in various branches of science and technique. The present investigation is aimed at study of the opportunities for gallium-nickel cyclotron targets production. These targets should be utilized for production of cobalt-57 and germanium-68. These two isotopes have medical and commercial value. Generally Germanium - 68 is used as a calibrating source for positron emission tomography (PET). PET becomes an admitted agent for the diagnosis of cardiac, neurologic and oncologic diseases in clinical practice. Every PET instrument should be calibrated by a source, containing positron emitter. Besides, each clinical scanning should be accompanied by careful scanning of 'transmission' to receive correct interpretation of image. Germanium- 68 decays on gallium - 68 which is the positron emitter. The long half-life of germanium -68 (271 day) and its disadvantage caused by single photon emission makes its an ideal as isotope for this calibration and source of transmission. Actually any other isotope does not come nearer to its opportunity and safety for these applications. Now every PET camera uses this isotope as a sources of transmission and, with rapidly growing demand propagation in use of this technology, the inquiry on 68 Ge for these sources extends. Therefore the generator 68 Ge - 68 Ga represents a major interest for a positron emission tomography due to unique accuracy and informativity. Electrochemical deposition of metals is widely used in cyclotron technology for producing of cyclotron targets. The given method has the following advantages: 1. This method is relatively cheap. 2. The opportunity to receive high purity metallic coating as, in many cases, at electrochemical deposition of metals there is additional purification (refining) of settled metals. Thus the bulk of impurities remains in electrolyte solution. Selecting compositions of electrolyte and conditions of

  15. Target validation for FCV technology development in Japan from energy competition point of view

    International Nuclear Information System (INIS)

    ENDO Eiichi

    2006-01-01

    The objective of this work is to validate the technical targets in the governmental hydrogen energy road-map of Japan by analyzing market penetration of fuel cell vehicle(FCV)s and effects of fuel price and carbon tax on it from technology competition point of view. In this analysis, an energy system model of Japan based on MARKAL is used. The results of the analysis show that hydrogen FCVs could not have cost-competitiveness until 2030 without carbon tax, including the governmental actual plan of carbon tax. However, as the carbon tax rate increases, instead of conventional vehicles including gasoline hybrid electric vehicle, hydrogen FCVs penetrate to the market earlier and more. By assuming higher fuel price and severer carbon tax rate, market share of hydrogen FCVs approaches to the governmental goal. This suggests that cheaper vehicle cost and/or hydrogen price than those targeted in the road-map is required. At the same time, achievement of the technical targets in the road-map also allows to attain the market penetration target of hydrogen FCVs in some possible conditions. (authors)

  16. 2010 national progress report on R and D on LEU fuel and target technology in Argentina

    International Nuclear Information System (INIS)

    Balart, S.; Blaumann, H.; Cristini, P.; Gonzalez, A.G.; Gonzalez, R.; Hermida, J.D.; Lopez, M.; Mirandou, M.; Taboada, H.

    2010-01-01

    Since last RRFM meeting, CNEA has deployed several related tasks. The RA-6 MTR type reactor, converted its core from HEU to a new LEU silicide one is scaling up the power, according to a protocol requested by the national regulatory body, ARN. CNEA is deploying an intense R and D activity to fabricate both dispersed U-Mo (Al-Si matrix and Al cladding) and monolithic (Zry-4 cladding) miniplates to develop possible solutions to VHD dispersed and monolithic fuels technical problems. Some monolithic 58% enrichment U8%Mo and U10%Mo are being delivered to INL-DoE to be irradiated in ATR reactor core. A conscientious study on compound interphase formation in both cases is being carried out. CNEA, a worldwide leader on LEU technology for fission radioisotope production is providing Brazil with these radiopharmaceutical products and Egypt and Australia with the technology through INVAP SE. CNEA is also committed to improve the diffusion of LEU target and radiochemical technology for radioisotope production and target and process optimization. Future plans include: 1) Fabrication of a LEU dispersed U-Mo fuel prototype following the recommendations of the IAEA's Good Practices document, to be irradiated in a high flux reactor in the frame of the ARG/4/092 IAEA's Technical Cooperation project. 2) Development of LEU very high density monolithic and dispersed U-Mo fuel plates with Zry-4 or Al cladding as a part of the RERTR program. 3) Optimization of LEU target and radiochemical techniques for radioisotope production. (author)

  17. Implementation of Mobile Target Positioning Technology Integrating SINS with WSN Measurements

    Directory of Open Access Journals (Sweden)

    Chengming Luo

    2014-01-01

    Full Text Available Accurate and robust positioning technology is expected to promote management level and service efficiency in various industrial applications. The strap-down inertial navigation system (SINS approach has short-term accurate positioning performance, but the SINS is known for its accumulative error over time. Meanwhile, wireless sensor networks (WSN approach can keep the mobile target on effective tracking after a long time monitoring, but the WSN may have large positioning error in certain areas. In order to make the positioning method allow profit from their advantages, this paper proposes a positioning technology using SINS approach in conjunction with WSN approach. The measurement parameters by SINS and WSN approaches are used. Then the SINS, anchor nodes, mobile tags, XBee, and computer are applied to design the positioning system. The estimation results indicate that the proposed method can make up for the shortcomings by pure SINS or WSN method and can be available for some accurate and robust applications.

  18. Targeted Gene Manipulation in Plants Using the CRISPR/Cas Technology.

    Science.gov (United States)

    Zhang, Dandan; Li, Zhenxiang; Li, Jian-Feng

    2016-05-20

    The CRISPR/Cas technology is emerging as a revolutionary genome editing tool in diverse organisms including plants, and has quickly evolved into a suite of versatile tools for sequence-specific gene manipulations beyond genome editing. Here, we review the most recent applications of the CRISPR/Cas toolkit in plants and also discuss key factors for improving CRISPR/Cas performance and strategies for reducing the off-target effects. Novel technical breakthroughs in mammalian research regarding the CRISPR/Cas toolkit will also be incorporated into this review in hope to stimulate prospective users from the plant research community to fully explore the potential of these technologies. Copyright © 2016 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

  19. Peak Experience Project

    Science.gov (United States)

    Scott, Daniel G.; Evans, Jessica

    2010-01-01

    This paper emerges from the continued analysis of data collected in a series of international studies concerning Childhood Peak Experiences (CPEs) based on developments in understanding peak experiences in Maslow's hierarchy of needs initiated by Dr Edward Hoffman. Bridging from the series of studies, Canadian researchers explore collected…

  20. [Overview of patents on targeted genome editing technologies and their implications for innovation and entrepreneurship education in universities].

    Science.gov (United States)

    Fan, Xiang-yu; Lin, Yan-ping; Liao, Guo-jian; Xie, Jian-ping

    2015-12-01

    Zinc finger nuclease, transcription activator-like effector nuclease, and clustered regularly interspaced short palindromic repeats/Cas9 nuclease are important targeted genome editing technologies. They have great significance in scientific research and applications on aspects of functional genomics research, species improvement, disease prevention and gene therapy. There are past or ongoing disputes over ownership of the intellectual property behind every technology. In this review, we summarize the patents on these three targeted genome editing technologies in order to provide some reference for developing genome editing technologies with self-owned intellectual property rights and some implications for current innovation and entrepreneurship education in universities.

  1. Overview on materials and technological developments for the LMJ cryogenic target assembly

    International Nuclear Information System (INIS)

    Reneaume, B.; Allegre, G.; Botrel, R.; Bourcier, H.; Bourdenet, R.; Breton, O.; Collier, R.; Dauteuil, C.; Durut, F.; Faivre, A.; Fleury, E.; Geoffray, I.; Geoffray, G.; Jeannot, L.; Jehanno, L.; Legaie, O.; Legay, G.; Meux, S.; Schunk, J.; Theobald, M.; Vasselin, C.; Perin, J.P.; Viargues, F.; Paquignon, G.

    2011-01-01

    The cryogenic target assemblies (CTAs) designed for Laser Megajoule (LMJ) experiments have many functions and have to meet severe specifications imposed by implosion physics, the CTA thermal environment, and the CTA interfaces with the Megajoule laser cryogenic target positioner. Therefore, CTA fabrication uses many challenging materials and requires several technological studies. During the last 2 years, many developments have enabled better collection of comprehensive data on target constitutive materials and improvements in the fabrication of the CTA base, hohlraum, and aluminum turret. Studies have been carried out (a) to better characterize thermal properties of materials allowing optimization of the thermal simulation of the hohlraum, (b) to improve the CTA base fabrication process in order optimize thermal studies of the LMJ experimental filling station (EFS), and (c) to determine coatings on the polyimide membrane that may limit the 300 K thermal effect on the micro-shell and increase the deuterium-tritium fuel lifetime. CTAs have been produced to evaluate fabrication knowledge, to characterize CTAs, to study air tightness, and to study filling and D 2 ice layering on the EFS. An overview of the results that have been obtained during the past 2 years is presented in this paper. (authors)

  2. Peak power ratio generator

    Science.gov (United States)

    Moyer, R.D.

    A peak power ratio generator is described for measuring, in combination with a conventional power meter, the peak power level of extremely narrow pulses in the gigahertz radio frequency bands. The present invention in a preferred embodiment utilizes a tunnel diode and a back diode combination in a detector circuit as the only high speed elements. The high speed tunnel diode provides a bistable signal and serves as a memory device of the input pulses for the remaining, slower components. A hybrid digital and analog loop maintains the peak power level of a reference channel at a known amount. Thus, by measuring the average power levels of the reference signal and the source signal, the peak power level of the source signal can be determined.

  3. Peak Oil, Peak Coal and Climate Change

    Science.gov (United States)

    Murray, J. W.

    2009-05-01

    Research on future climate change is driven by the family of scenarios developed for the IPCC assessment reports. These scenarios create projections of future energy demand using different story lines consisting of government policies, population projections, and economic models. None of these scenarios consider resources to be limiting. In many of these scenarios oil production is still increasing to 2100. Resource limitation (in a geological sense) is a real possibility that needs more serious consideration. The concept of 'Peak Oil' has been discussed since M. King Hubbert proposed in 1956 that US oil production would peak in 1970. His prediction was accurate. This concept is about production rate not reserves. For many oil producing countries (and all OPEC countries) reserves are closely guarded state secrets and appear to be overstated. Claims that the reserves are 'proven' cannot be independently verified. Hubbert's Linearization Model can be used to predict when half the ultimate oil will be produced and what the ultimate total cumulative production (Qt) will be. US oil production can be used as an example. This conceptual model shows that 90% of the ultimate US oil production (Qt = 225 billion barrels) will have occurred by 2011. This approach can then be used to suggest that total global production will be about 2200 billion barrels and that the half way point will be reached by about 2010. This amount is about 5 to 7 times less than assumed by the IPCC scenarios. The decline of Non-OPEC oil production appears to have started in 2004. Of the OPEC countries, only Saudi Arabia may have spare capacity, but even that is uncertain, because of lack of data transparency. The concept of 'Peak Coal' is more controversial, but even the US National Academy Report in 2007 concluded only a small fraction of previously estimated reserves in the US are actually minable reserves and that US reserves should be reassessed using modern methods. British coal production can be

  4. Peak regulation right

    International Nuclear Information System (INIS)

    Gao, Z. |; Ren, Z.; Li, Z.; Zhu, R.

    2005-01-01

    A peak regulation right concept and corresponding transaction mechanism for an electricity market was presented. The market was based on a power pool and independent system operator (ISO) model. Peak regulation right (PRR) was defined as a downward regulation capacity purchase option which allowed PRR owners to buy certain quantities of peak regulation capacity (PRC) at a specific price during a specified period from suppliers. The PRR owner also had the right to decide whether or not they would buy PRC from suppliers. It was the power pool's responsibility to provide competitive and fair peak regulation trading markets to participants. The introduction of PRR allowed for unit capacity regulation. The PRR and PRC were rated by the supplier, and transactions proceeded through a bidding process. PRR suppliers obtained profits by selling PRR and PRC, and obtained downward regulation fees regardless of whether purchases are made. It was concluded that the peak regulation mechanism reduced the total cost of the generating system and increased the social surplus. 6 refs., 1 tab., 3 figs

  5. Application of real-time single camera SLAM technology for image-guided targeting in neurosurgery

    Science.gov (United States)

    Chang, Yau-Zen; Hou, Jung-Fu; Tsao, Yi Hsiang; Lee, Shih-Tseng

    2012-10-01

    In this paper, we propose an application of augmented reality technology for targeting tumors or anatomical structures inside the skull. The application is a combination of the technologies of MonoSLAM (Single Camera Simultaneous Localization and Mapping) and computer graphics. A stereo vision system is developed to construct geometric data of human face for registration with CT images. Reliability and accuracy of the application is enhanced by the use of fiduciary markers fixed to the skull. The MonoSLAM keeps track of the current location of the camera with respect to an augmented reality (AR) marker using the extended Kalman filter. The fiduciary markers provide reference when the AR marker is invisible to the camera. Relationship between the markers on the face and the augmented reality marker is obtained by a registration procedure by the stereo vision system and is updated on-line. A commercially available Android based tablet PC equipped with a 320×240 front-facing camera was used for implementation. The system is able to provide a live view of the patient overlaid by the solid models of tumors or anatomical structures, as well as the missing part of the tool inside the skull.

  6. Integration of intracellular telomerase monitoring by electrochemiluminescence technology and targeted cancer therapy by reactive oxygen species.

    Science.gov (United States)

    Zhang, Huairong; Li, Binxiao; Sun, Zhaomei; Zhou, Hong; Zhang, Shusheng

    2017-12-01

    Cancer therapies based on reactive oxygen species (ROS) have emerged as promising clinical treatments. Electrochemiluminescence (ECL) technology has also attracted considerable attention in the field of clinical diagnosis. However, studies about the integration of ECL diagnosis and ROS cancer therapy are very rare. Here we introduce a novel strategy that employs ECL technology and ROS to fill the above vacancy. Briefly, an ITO electrode was electrodeposited with polyluminol-Pt NPs composite films and modified with aptamer DNA to capture HL-60 cancer cells with high specificity. After that, mesoporous silica nanoparticles (MSNs) filled with phorbol 12-myristate 13-acetate (PMA) were closed by the telomerase primer DNA (T-primer DNA) and aptamer. After aptamer on MSN@PMA recognized and combined with the HL-60 cancer cells with high specificity, T-primer DNA on MSN@PMA could be moved away from the MSN@PMA surface after extension by telomerase in the HL-60 cancer cells and PMA was released to induce the production of ROS by the HL-60 cancer cells. After that, the polyluminol-Pt NPs composite films could react with hydrogen peroxide (a major ROS) and generate an ECL signal. Thus the intracellular telomerase activity of the HL-60 cancer cells could be detected in situ . Besides, ROS could induce apoptosis in the HL-60 cancer cells with high efficacy by causing oxidative damage to the lipids, protein, and DNA. Above all, the designed platform could not only detect intracellular telomerase activity instead of that of extracted telomerase, but could also kill targeted tumors by ECL technology and ROS.

  7. Peak-interviewet

    DEFF Research Database (Denmark)

    Raalskov, Jesper; Warming-Rasmussen, Bent

    Peak-interviewet er en særlig effektiv metode til at gøre ubevidste menneskelige ressourcer bevidste. Fokuspersonen (den interviewede) interviewes om en selvvalgt, personlig succesoplevelse. Terapeuten/coachen (intervieweren) spørger ind til processen, som ledte hen til denne succes. Herved afdæk...

  8. Automated asteroseismic peak detections

    Science.gov (United States)

    García Saravia Ortiz de Montellano, Andrés; Hekker, S.; Themeßl, N.

    2018-05-01

    Space observatories such as Kepler have provided data that can potentially revolutionize our understanding of stars. Through detailed asteroseismic analyses we are capable of determining fundamental stellar parameters and reveal the stellar internal structure with unprecedented accuracy. However, such detailed analyses, known as peak bagging, have so far been obtained for only a small percentage of the observed stars while most of the scientific potential of the available data remains unexplored. One of the major challenges in peak bagging is identifying how many solar-like oscillation modes are visible in a power density spectrum. Identification of oscillation modes is usually done by visual inspection that is time-consuming and has a degree of subjectivity. Here, we present a peak-detection algorithm especially suited for the detection of solar-like oscillations. It reliably characterizes the solar-like oscillations in a power density spectrum and estimates their parameters without human intervention. Furthermore, we provide a metric to characterize the false positive and false negative rates to provide further information about the reliability of a detected oscillation mode or the significance of a lack of detected oscillation modes. The algorithm presented here opens the possibility for detailed and automated peak bagging of the thousands of solar-like oscillators observed by Kepler.

  9. Technology strategy for integrated operations and real time reservoir management; Technology Target Areas; TTA5 - Integrated operations and RTRM

    Energy Technology Data Exchange (ETDEWEB)

    2007-07-01

    In Norway Integrated Operations (IO) is a concept which in the first phase (G1) has been used to describe how to integrate processes and people onshore and offshore using ICT solutions and facilities that improve onshore's ability to support offshore operationally. The second generation (G2) Integrated Operations aims to help operators utilize vendors' core competencies and services more efficiently. Utilizing digital services and vendor products, operators will be able to update reservoir models, drilling targets and well trajectories as wells are drilled, manage well completions remotely, optimize production from reservoir to export lines, and implement condition-based maintenance concepts. The total impact on production, recovery rates, costs and safety will be profound. When the international petroleum business moves to the Arctic region the setting is very different from what is the case on the Norwegian Continental Shelf (NCS) and new challenges will arise. The Norwegian Ministry of Environment has recently issued an Integrated Management Plan for the Barents Sea where one focus is on 'Monitoring of the Marine Environment in the North'. The Government aims to establish a new and more coordinated system for monitoring the marine ecosystems in the north. A representative group consisting of the major Operators, the Service Industry, Academia and the Authorities have developed the enclosed strategy for the OG21 Integrated Operations and Real Time Reservoir Management (IO and RTRM) Technology Target Area (TTA). Major technology and work process research and development gaps have been identified in several areas: Bandwidth down-hole to surface; Sensor development including Nano-technology; Cross discipline use of Visualisation, Simulation and model development particularly in Drilling and Reservoir management areas; Software development in terms of data handling, model updating and calculation speed; Enabling reliable and robust communications

  10. Twin Peaks (B/W)

    Science.gov (United States)

    1997-01-01

    The Twin Peaks are modest-size hills to the southwest of the Mars Pathfinder landing site. They were discovered on the first panoramas taken by the IMP camera on the 4th of July, 1997, and subsequently identified in Viking Orbiter images taken over 20 years ago. The peaks are approximately 30-35 meters (-100 feet) tall. North Twin is approximately 860 meters (2800 feet) from the lander, and South Twin is about a kilometer away (3300 feet). The scene includes bouldery ridges and swales or 'hummocks' of flood debris that range from a few tens of meters away from the lander to the distance of the South Twin Peak. The large rock at the right edge of the scene is nicknamed 'Hippo'. This rock is about a meter (3 feet) across and 25 meters (80 feet) distant.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  11. Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA.

    Directory of Open Access Journals (Sweden)

    Sisse B Ditlev

    Full Text Available Placental malaria is a major health problem for both pregnant women and their fetuses in malaria endemic regions. It is triggered by the accumulation of Plasmodium falciparum-infected erythrocytes (IE in the intervillous spaces of the placenta and is associated with foetal growth restriction and maternal anemia. IE accumulation is supported by the binding of the parasite-expressed protein VAR2CSA to placental chondroitin sulfate A (CSA. Defining specific CSA-binding epitopes of VAR2CSA, against which to target the immune response, is essential for the development of a vaccine aimed at blocking IE adhesion. However, the development of a VAR2CSA adhesion-blocking vaccine remains challenging due to (i the large size of VAR2CSA and (ii the extensive immune selection for polymorphisms and thereby non-neutralizing B-cell epitopes. Camelid heavy-chain-only antibodies (HcAbs are known to target epitopes that are less immunogenic to classical IgG and, due to their small size and protruding antigen-binding loop, able to reach and recognize cryptic, conformational epitopes which are inaccessible to conventional antibodies. The variable heavy chain (VHH domain is the antigen-binding site of camelid HcAbs, the so called Nanobody, which represents the smallest known (15 kDa intact, native antigen-binding fragment. In this study, we have used the Nanobody technology, an approach new to malaria research, to generate small and functional antibody fragments recognizing unique epitopes broadly distributed on VAR2CSA.

  12. Twin Peaks - 3D

    Science.gov (United States)

    1997-01-01

    The two hills in the distance, approximately one to two kilometers away, have been dubbed the 'Twin Peaks' and are of great interest to Pathfinder scientists as objects of future study. 3D glasses are necessary to identify surface detail. The white areas on the left hill, called the 'Ski Run' by scientists, may have been formed by hydrologic processes.The IMP is a stereo imaging system with color capability provided by 24 selectable filters -- twelve filters per 'eye.Click below to see the left and right views individually. [figure removed for brevity, see original site] Left [figure removed for brevity, see original site] Right

  13. Technology strategy for deepwater and subsea production systems 2008 update; Technology Target Areas; TTA7 - Deep water and subsea prodution technology

    Energy Technology Data Exchange (ETDEWEB)

    2008-07-01

    Executive summary 'Deepwater and Subsea Production Systems' has been identified as one of the eight new Technology Target Areas (TTAs) in Norway's technology strategy for the Oil and Gas sector. This TTA covers deepwater floating production systems, subsea systems (except subsea processing technologies which are addressed by TTA6) and arctic development systems (in both shallow and deepwater). The total hydrocarbon reserves worldwide, which are enabled by the technologies under this TTA exceed 400 billion boe which, itself exceeds the proven reserves of Saudi Arabia. For deepwater developments the long term technical challenge is to develop flexible and adaptive systems which are better able to cope with subsurface uncertainties e.g. compartmentalisation and provide required access to the reservoir to enable successful recovery. More specific medium term challenges relate to developing solutions for harsh environmental conditions such as those offshore Norway and to develop cost effective methods of installing subsea hardware in deep and ultra deep water without requiring expensive crane vessels. For subsea systems the challenge is to develop solutions for ultra deepwater without increasing costs, so that Norway's leading export position in this area can be maintained and strengthened. Considering developments in the arctic, Norwegian industry is already well placed through its familiarity with arctic climate, close relationship with Russia and involvement in Sakhalin II. As we move to water depth beyond about 150m use of Gravity Base Structures (GBS) becomes very expensive or non-feasible and we need to consider other solutions. Subsea-to-beach could be an attractive solution but we need to resolve challenges related to long distance tie backs, flow assurance, uneven terrain, etc. There is also a specific need to develop floating systems capable of drilling and production in an arctic environment. To address the above technical challenges the

  14. H-TArget model: Early technology assessment for ext generation sequencing in oncology

    NARCIS (Netherlands)

    Retel, Valesca P.; Joore, Manuela A.; Ramaekers, Bram; van den Heuvel, Michel M.; van der Heijden, Michiel Simon; van Harten, Willem H.

    2015-01-01

    Background: Next Generation Sequencing (NGS) promises to find mutations (targets) in individual cancer patients, to subsequently prescribe targeted therapy. Currently, NGS is in development, the effects on choice of therapy and prognosis are still unclear, and the costs for targeted therapies are

  15. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1995--September 30, 1996

    International Nuclear Information System (INIS)

    Hoppe, M.

    1997-02-01

    On December 30, 1990, the U.S. Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. In September 1995 this contract ended and a second contract was issued for us to continue this ICF target support work. This report documents the technical activities of the period October 1, 1995 through September 30, 1996. During this period, GA and our partners WJ Schafer Associates (WJSA) and Soane Technologies, Inc. (STI) were assigned 14 formal tasks in support of the Inertial Confinement Fusion program and its five laboratories. A portion of the effort on these tasks included providing direct open-quotes Onsite Supportclose quotes at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). We fabricated and delivered over 800 gold-plated hohlraum mandrels to LLNL, LANL and SNLA. We produced nearly 1,200 glass and plastic target capsules for LLNL, LANL, SNLA and University of Rochester/Laboratory for Laser Energetics (UR/LLE). We also delivered over 100 flat foil targets for Naval Research Lab (NRL) and SNLA in FY96. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require capsules containing cryogenic layered D 2 or deuterium-tritium (DT) fuel. We are part of the National Cryogenic Target Program to create and demonstrate viable ways to generate and characterize cryogenic layers. Substantial progress has been made on ways to both create and characterize viable layers. During FY96, significant progress was made in the design of the OMEGA Cryogenic Target System that will field cryogenic targets on OMEGA

  16. New design targets and new automated technology for the production of radionuclides with high specificity radioactivity in nuclear research reactors

    International Nuclear Information System (INIS)

    Gerasimov, A.S.; Kiselev, G.V.

    1997-01-01

    Current demands of industry require the application of radionuclides with high specific radioactivity under low consumption of neutrons. To provide this aim staff of ITEP Reactor Department investigated the different type AEs of start targets for the production of the main radionuclides; Co-60, Ir-192 and others. In first turn the targets of Co and Ir without the block-effect of neutron flux (with low absorption of neutrons) were investigated. The following principal results were received for example for Ir-192: block effect is equal 0.086 for diameter of Ir target mm and is equal 0.615 for diameter Ir target 0.5mm. It means average neutron flux for Ir target diameter 0.5mm and therefore the production of Ir-192 will be at 10 times more than for diameter 6.0mm. To provide the automated technology of the manufacture of radioactive sources with radionuclides with high specific radioactivity it was proposed that the compound targets for the irradiation of ones and for the management with the irradiated targets. Different types of compound targets were analyzed. (authors)

  17. New design targets and new automated technology for the production of radionuclides with high specificity radioactivity in nuclear research reactors

    Energy Technology Data Exchange (ETDEWEB)

    Gerasimov, A.S.; Kiselev, G.V. [State Russian Center of the Russian Federation, Moscow (Russian Federation). Institute of Theoretical and Experimental Physics

    1997-10-01

    Current demands of industry require the application of radionuclides with high specific radioactivity under low consumption of neutrons. To provide this aim staff of ITEP Reactor Department investigated the different type AEs of start targets for the production of the main radionuclides; Co-60, Ir-192 and others. In first turn the targets of Co and Ir without the block-effect of neutron flux (with low absorption of neutrons) were investigated. The following principal results were received for example for Ir-192: block effect is equal 0.086 for diameter of Ir target mm and is equal 0.615 for diameter Ir target 0.5mm. It means average neutron flux for Ir target diameter 0.5mm and therefore the production of Ir-192 will be at 10 times more than for diameter 6.0mm. To provide the automated technology of the manufacture of radioactive sources with radionuclides with high specific radioactivity it was proposed that the compound targets for the irradiation of ones and for the management with the irradiated targets. Different types of compound targets were analyzed. (authors)

  18. FST-technologies for high rep-rate production of HiPER scale cryogenic targets

    Science.gov (United States)

    Aleksandrova, I. V.; Belolipetskiy, A. A.; Kalabuhov, V. A.; Koresheva, E. R.; Koshelev, E. L.; Kutergin, A. I.; Nikitenko, A. I.; Osipov, I. E.; Panina, L. V.; Safronov, A. I.; Timasheva, T. P.; Timofeev, I. D.; Usachev, G. S.; Chtcherbakov, V. I.; Tolley, M.; Edwards, C.; Spindloe, C.

    2011-06-01

    The target factory of an Inertial Fusion Energy (IFE) power plant (or reactor) must supply the targets with a rate of 1-10 Hz including their injection and transport through the chamber. HiPER is a proposed European High Power laser Energy Research facility dedicated to demonstrate the feasibility of laser driven fusion for IFE reactor. The work of HiPER facility requires formation & delivery of cryogenic free-standing targets with a rate of more than 1 Hz. To meet these requirements, an approach to fuel layering based on conduction cooling of a batch of moving spherical targets has been developed at the Lebedev Physical Institute (LPI). The approach demands to use free-standing targets in each production step: fuel filling, fuel layering, target characterization and injection. In this report, the expert results on the development of a specialized layering module prototype for a high reprate FST formation of HiPER cryogenic targets are presented.

  19. USING COMPUTER TECHNOLOGIES IN REALIZATION OF MAIN TARGETS IN MODERN BIOLOGY EDUCATION

    Directory of Open Access Journals (Sweden)

    Iryna Yu. Slipchuk

    2010-08-01

    Full Text Available The main problem of this article is using the computer technologies in the process of biology education. This article contains the results of explorations in computer technologies and the influence of these technologies on the quality of knowledge and level of progress in secondary school.

  20. Prediction on the Peak of the CO2 Emissions in China Using the STIRPAT Model

    Directory of Open Access Journals (Sweden)

    Li Li

    2016-01-01

    Full Text Available Climate change has threatened our economic, environmental, and social sustainability seriously. The world has taken active measures in dealing with climate change to mitigate carbon emissions. Predicting the carbon emissions peak has become a global focus, as well as a leading target for China’s low carbon development. China has promised its carbon emissions will have peaked by around 2030, with the intention of peaking earlier. Scholars generally have studied the influencing factors of carbon emissions. However, research on carbon emissions peaks is not extensive. Therefore, by setting a low scenario, a middle scenario, and a high scenario, this paper predicts China’s carbon emissions peak from 2015 to 2035 based on the data from 1998 to 2014 using the Stochastic Impacts by Regression on Population, Affluence, and Technology (STIRPAT model. The results show that in the low, middle, and high scenarios China will reach its carbon emissions peak in 2024, 2027, and 2030, respectively. Thus, this paper puts forward the large-scale application of technology innovation to improve energy efficiency and optimize energy structure and supply and demand. China should use industrial policy and human capital investment to stimulate the rapid development of low carbon industries and modern agriculture and service industries to help China to reach its carbon emissions peak by around 2030 or earlier.

  1. Development and evaluation of a targeted orchard sprayer using machine vision technology

    Directory of Open Access Journals (Sweden)

    H Asaei

    2016-09-01

    Full Text Available Introduction In conventional methods of spraying in orchards, the amount of pesticide sprayed, is not targeted. The pesticide consumption data indicates that the application rate of pesticide in greenhouses and orchards is more than required. Less than 30% of pesticide sprayed actually reaches nursery canopies while the rest are lost and wasted. Nowadays, variable rate spray applicators using intelligent control systems can greatly reduce pesticide use and off-target contamination of environment in nurseries and orchards. In this research a prototype orchard sprayer based on machine vision technology was developed and evaluated. This sprayer performs real-time spraying based on the tree canopy structure and its greenness extent which improves the efficiency of spraying operation in orchards. Materials and Methods The equipment used in this study comprised of three main parts generally: 1- Mechanical Equipment 2- Data collection and image processing system 3- Electronic control system Two booms were designed to support the spray nozzles and to provide flexibility in directing the spray nozzles to the target. The boom comprised two parts, the vertical part and inclined part. The vertical part of the boom was used to spray one side of the trees during forward movement of the tractor and inclined part of the boom was designed to spray the upper half of the tree canopy. Three nozzles were considered on each boom. On the vertical part of the boom, two nozzles were placed, whereas one other nozzle was mounted on the inclined part of the boom. To achieve different tree heights, the vertical part of the boom was able to slide up and down. Labview (version 2011 was used for real time image processing. Images were captured through RGB cameras mounted on a horizontal bar attached on top of the tractor to take images separately for each side of the sprayer. Images were captured from the top of the canopies looking downward. The triggering signal for

  2. Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets.

    Science.gov (United States)

    Wong, Vincent Kam-Wai; Law, Betty Yuen-Kwan; Yao, Xiao-Jun; Chen, Xi; Xu, Su Wei; Liu, Liang; Leung, Elaine Lai-Han

    2016-09-01

    Traditional biotechnology has been utilized by human civilization for long in wide aspects of our daily life, such as wine and vinegar production, which can generate new phytochemicals from natural products using micro-organism. Today, with advanced biotechnology, diverse applications and advantages have been exhibited not only in bringing benefits to increase the diversity and composition of herbal phytochemicals, but also helping to elucidate the treatment mechanism and accelerate new drug discovery from Chinese herbal medicine (CHM). Applications on phytochemical biotechnologies and microbial biotechnologies have been promoted to enhance phytochemical diversity. Cell labeling and imaging technology and -omics technology have been utilized to elucidate CHM treatment mechanism. Application of computational methods, such as chemoinformatics and bioinformatics provide new insights on direct target of CHM. Overall, these technologies provide efficient ways to overcome the bottleneck of CHM, such as helping to increase the phytochemical diversity, match their molecular targets and elucidate the treatment mechanism. Potentially, new oriented herbal phytochemicals and their corresponding drug targets can be identified. In perspective, tighter integration of multi-disciplinary biotechnology and computational technology will be the cornerstone to accelerate new arena formation, advancement and revolution in the fields of CHM and world pharmaceutical industry. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Capabilities of the Los Alamos National Laboratory in nuclear target technology

    International Nuclear Information System (INIS)

    Gursky, J.C.

    1984-01-01

    Targets are made at Los Alamos for experiments at the Ion Beam Facility (Van de Graaff), the Medium Energy Physics Facility (LAMPF), and for experiments conducted at many other accelerators in the US and Europe. Thin, isotopic targets are made by sputtering and evaporation. Versatile, large-scale facilities exist for ceramics and plastics fabrication, electroplating, powder metallurgy, fabrication by pressing, casting and rolling, chemical and physical vapor deposition and sputtering. Special developments include ultra-precision machining, cryogenic targets and shaped-foil targets. 20 references

  4. Continuing investigations for technology assessment of 99Mo production from LEU [low enriched uranium] targets

    International Nuclear Information System (INIS)

    Vandegrift, G.F.; Kwok, J.D.; Marshall, S.L.; Vissers, D.R.; Matos, J.E.

    1987-01-01

    Currently much of the world's supply of 99m Tc for medical purposes is produced from 99 Mo derived from the fissioning of high enriched uranium (HEU). This paper presents the results of our continuing studies on the effects of substituting low enriched uranium (LEU) for HEU in targets for the production of fission product 99 Mo. Improvements in the electrodeposition of thin films of uranium metal continue to increase the appeal for the substitution of LEU metal for HEU oxide films in cylindrical targets. The process is effective for targets fabricated from stainless steel or zircaloy. Included is a cost estimate for setting up the necessary equipment to electrodeposit uranium metal on cylindrical targets. Further investigations on the effect of LEU substitution on processing of these targets are also reported. Substitution of uranium silicides for the uranium-aluminium alloy or uranium aluminide dispersed fuel used in current target designs will allow the substitution of LEU for HEU in these targets with equivalent 99 Mo-yield per target and no change in target geometries. However, this substitution will require modifications in current processing steps due to 1) the insolubility of uranium silicides in alkaline solutions and 2) the presence of significant quantities of silicate in solution. Results to date suggest that substitution of LEU for HEU can be achieved. (Author)

  5. Integration of multidisciplinary technologies for real time target visualization and verification for radiotherapy.

    Science.gov (United States)

    Chang, Wen-Chung; Chen, Chin-Sheng; Tai, Hung-Chi; Liu, Chia-Yuan; Chen, Yu-Jen

    2014-01-01

    The current practice of radiotherapy examines target coverage solely from digitally reconstructed beam's eye view (BEV) in a way that is indirectly accessible and that is not in real time. We aimed to visualize treatment targets in real time from each BEV. The image data of phantom or patients from ultrasound (US) and computed tomography (CT) scans were captured to perform image registration. We integrated US, CT, US/CT image registration, robotic manipulation of US, a radiation treatment planning system, and a linear accelerator to constitute an innovative target visualization system. The performance of this algorithm segmented the target organ in CT images, transformed and reconstructed US images to match each orientation, and generated image registration in real time mode with acceptable accuracy. This image transformation allowed physicians to visualize the CT image-reconstructed target via a US probe outside the BEV that was non-coplanar to the beam's plane. It allowed the physicians to remotely control the US probe that was equipped on a robotic arm to dynamically trace and real time monitor the coverage of the target within the BEV during a simulated beam-on situation. This target visualization system may provide a direct remotely accessible and real time way to visualize, verify, and ensure tumor targeting during radiotherapy.

  6. The Science and Technologies for Fusion Energy With Lasers and Direct-Drive Targets

    Science.gov (United States)

    2010-04-01

    exposed at prototypical neutron fluence and temperature using the Oak Ridge National Laboratory (ORNL) HFIR . After exposure, the samples showed no visible...after exposure to neutrons from the ORNL HFIR . Fig. 9. (Left) Buildup of a high-gain target. The dimensions and aspect ratio vary for the various target

  7. Fabrication technology for a series of cylindrical thin-wall cavity targets

    CERN Document Server

    Zheng Yong; Sun Zu Oke; Wang Ming Da; Zhou La; Zhou Zhi Yun

    2002-01-01

    Cylindrical thin-wall cavity targets have been fabricated to study the behavior of superthermal electrons and their effects on inertial confinement fusion (ICF). Self-supporting cavity targets having adjustable, uniform wall thickness, and low surface roughness were required. This required production of high-quality mandrels, coating them by sputtering or electroplating, developing techniques for measurement of wall thickness and other cavity parameters, improving the uniformity of rotation of the mandrels, and preventing damage to the targets during removal from the mandrels. Details of the fabrication process are presented. Experimental results from the use of these targets are presented. These results, in good agreement with simulations, indicate that the use of thin-wall cavity targets is an effective method for studying superthermal electrons in ICF.

  8. Energy technologies for Post Kyoto targets in the medium term. Proceedings

    DEFF Research Database (Denmark)

    2003-01-01

    The Risø International Energy Conference took place 19 - 21 May 2003 and the aim was to present and discuss new developments and trends in energy technologies which may become main contributors to the energy scene in 15 to 20 years. The conferenceaddressed R&D related to the individual technologies...

  9. Biosocial Spaces and Neurocomputational Governance: Brain-Based and Brain-Targeted Technologies in Education

    Science.gov (United States)

    Williamson, Ben; Pykett, Jessica; Nemorin, Selena

    2018-01-01

    Recently, technologies based on neuroscientific insights into brain function and structure have been promoted for application in education. The novel practices and environments produced by these technologies require new forms of "biosocial" analysis to unpack their implications for education, learning and governance. This article…

  10. Technology Issues and Benefits of a Fast Ignition Power Plant with Cone Targets

    International Nuclear Information System (INIS)

    Hogan, W J; Meier, W R

    2003-01-01

    The use of cone focus, fast ignition targets, either for direct or indirect drive, promises to lower the required driver size and relax the symmetry requirements in IFE power plants. It may also allow use of chamber concepts previously thought infeasible with a laser driver. These benefits will lower the COE and make IFE plants more competitive at smaller size. Their use also raises unique issues that will impact the design and development of power plant subsystems. Cone targets have a significant mass of high Z material whether or not they have a hohlraum and they are not spherically symmetric. This has implications for target injection, tracking and chamber background gas allowable

  11. Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1994--September 30, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Hoppe, M. [ed.

    1996-05-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities of the period October 1, 1994 through September 30, 1995. During this period, GA was assigned 15 tasks in support of the Inertial Confinement Fusion program and its laboratories. A portion of the effort on these tasks included providing direct ``Onsite Support`` at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). The ICF program is anticipating experiments at the National Ignition Facility (NIF) and the OMEGA Upgrade. Both facilities will require capsules containing layered D{sub 2} or deuterium-tritium (D-T) fuel. The authors are part of the National Cryogenic Target Program to create and demonstrate viable ways to generate and characterize cryogenic layers. Progress has been made on ways to both create viable layers and to characterize them. They continued engineering, assembly and testing of equipment for a cryogenic target handling system for University of Rochester`s Laboratory for Laser Energetics (UR/LLE) that will fill, transport, layer, and characterize targets filled with cryogenic fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments. This report summarizes and documents the technical progress made on these tasks.

  12. Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1994--September 30, 1995

    International Nuclear Information System (INIS)

    Hoppe, M.

    1996-05-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. This report documents the technical activities of the period October 1, 1994 through September 30, 1995. During this period, GA was assigned 15 tasks in support of the Inertial Confinement Fusion program and its laboratories. A portion of the effort on these tasks included providing direct ''Onsite Support'' at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). The ICF program is anticipating experiments at the National Ignition Facility (NIF) and the OMEGA Upgrade. Both facilities will require capsules containing layered D 2 or deuterium-tritium (D-T) fuel. The authors are part of the National Cryogenic Target Program to create and demonstrate viable ways to generate and characterize cryogenic layers. Progress has been made on ways to both create viable layers and to characterize them. They continued engineering, assembly and testing of equipment for a cryogenic target handling system for University of Rochester's Laboratory for Laser Energetics (UR/LLE) that will fill, transport, layer, and characterize targets filled with cryogenic fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments. This report summarizes and documents the technical progress made on these tasks

  13. Research on Ground Motion Metal Target Based on Rocket Projectile by Using Millimeter Wave Radiometer Technology

    Directory of Open Access Journals (Sweden)

    Zhang Dongyang

    2014-06-01

    Full Text Available How to detect the ground motion metal target effectively is an important guarantee for precision strike in the process of Rocket Projectile flight. Accordingly and in view of the millimeter- wave radiation characteristic of the ground motion metal target, a mathematical model was established based on Rocket Projectile about millimeter-wave detection to the ground motion metal target. Through changing various parameters in the process of Rocket Projectile flight, the detection model was studied by simulation. The parameters variation and effective range of millimeter wave radiometer were obtained in the process of rotation and horizontal flight. So a certain theoretical basis was formed for the precision strike to the ground motion metal target.

  14. Peak flow meter use - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100202.htm Peak flow meter use - Series—Peak flow meter use - part one To use the sharing ... slide 7 out of 7 Overview A peak flow meter helps you check how well your asthma ...

  15. Design and implement of infrared small target real-time detection system based on pipeline technology

    Science.gov (United States)

    Sun, Lihui; Wang, Yongzhong; He, Yongqiang

    2007-01-01

    The detection for motive small target in infrared image sequence has become a hot topic nowadays. Background suppress algorithm based on minim gradient median filter and temporal recursion target detection algorithm are introduced. On the basis of contents previously mentioned, a four stages pipeline structure infrared small target detection process system, which aims at characters of algorithm complexity, large amounts of data to process, high frame frequency and exigent real-time character in this kind of application, is designed and implemented. The logical structure of the system was introduced and the function and signals flows are programmed. The system is composed of two FPGA chips and two DSP chips of TI. According to the function of each part, the system is divided into image preprocess stage, target detection stage, track relation stage and image output stage. The experiment of running algorithms on the system presented in this paper proved that the system could meet acquisition and process of 50Hz 240x320 digital image and the system could real time detect small target with a signal-noise ratio more than 3 reliably. The system achieves the characters of large amount of memory, high real-time processing, excellent extension and favorable interactive interface.

  16. Preliminary investigations for technology assessment of 99Mo production from LEU [low enriched uranium] targets

    International Nuclear Information System (INIS)

    Vandegrift, G.F.; Chaiko, D.J.; Heinrich, R.R.; Kucera, E.T.; Jensen, K.J.; Poa, D.S.; Varma, R.; Vissers, D.R.

    1986-11-01

    This paper presents the results of preliminary studies on the effects of substituting low enriched uranium (LEU) for highly enriched uranium (HEU) in targets for the production of fission product 99 Mo. Issues that were addressed are: (1) purity and yield of the 99 Mo//sup 99m/Tc product, (2) fabrication of LEU targets and related concerns, and (3) radioactive waste. Laboratory experimentation was part of the efforts for issues (1) and (2); thus far, radioactive waste disposal has only been addressed in a paper study. Although the reported results are still preliminary, there is reason to be optimistic about the feasibility of utilizing LEU targets for 99 Mo production. 37 refs., 1 fig., 5 tabs

  17. Technology of preparation for low density 6Li(H,D) solid micro-target

    International Nuclear Information System (INIS)

    Wang Xisheng; Zeng Jiaquan; Li Qiang

    2002-01-01

    Low density 6 Li(H,D) micro-targets are prepared by loose sintering 6 LiH or 6 LiD powder in a tiny gold cylinder and soaking for 30 min up to 430 degree C at the rate of 10 degree C/h in argon. The dimension of the micro-targets is as tiny as 0.6-1.0 mm for diameter and 1-2 mm for length. Densities of 6 LiH and 6 LiD without Parylene C is (0.283 +- 0.009) g/cm 3 and (0.369 +- 0.009) g/cm 3 , respectively while 6 LiD targets with Parylene C is only (0.301 +- 0.010) g/cm 3 . The Parylene C has no effect on purity, deuterium abundance and 6 Li abundance of the sintered micro-targets. It's effective to keep 6 Li(H,D) purity by strict control of argon atmosphere

  18. Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA

    DEFF Research Database (Denmark)

    Ditlev, Sisse B; Florea, Raluca; Nielsen, Morten A

    2014-01-01

    called Nanobody, which represents the smallest known (15 kDa) intact, native antigen-binding fragment. In this study, we have used the Nanobody technology, an approach new to malaria research, to generate small and functional antibody fragments recognizing unique epitopes broadly distributed on VAR2CSA....

  19. SWATHtoMRM: Development of High-Coverage Targeted Metabolomics Method Using SWATH Technology for Biomarker Discovery.

    Science.gov (United States)

    Zha, Haihong; Cai, Yuping; Yin, Yandong; Wang, Zhuozhong; Li, Kang; Zhu, Zheng-Jiang

    2018-03-02

    The complexity of metabolome presents a great analytical challenge for quantitative metabolite profiling, and restricts the application of metabolomics in biomarker discovery. Targeted metabolomics using multiple-reaction monitoring (MRM) technique has excellent capability for quantitative analysis, but suffers from the limited metabolite coverage. To address this challenge, we developed a new strategy, namely, SWATHtoMRM, which utilizes the broad coverage of SWATH-MS technology to develop high-coverage targeted metabolomics method. Specifically, SWATH-MS technique was first utilized to untargeted profile one pooled biological sample and to acquire the MS 2 spectra for all metabolites. Then, SWATHtoMRM was used to extract the large-scale MRM transitions for targeted analysis with coverage as high as 1000-2000 metabolites. Then, we demonstrated the advantages of SWATHtoMRM method in quantitative analysis such as coverage, reproducibility, sensitivity, and dynamic range. Finally, we applied our SWATHtoMRM approach to discover potential metabolite biomarkers for colorectal cancer (CRC) diagnosis. A high-coverage targeted metabolomics method with 1303 metabolites in one injection was developed to profile colorectal cancer tissues from CRC patients. A total of 20 potential metabolite biomarkers were discovered and validated for CRC diagnosis. In plasma samples from CRC patients, 17 out of 20 potential biomarkers were further validated to be associated with tumor resection, which may have a great potential in assessing the prognosis of CRC patients after tumor resection. Together, the SWATHtoMRM strategy provides a new way to develop high-coverage targeted metabolomics method, and facilitates the application of targeted metabolomics in disease biomarker discovery. The SWATHtoMRM program is freely available on the Internet ( http://www.zhulab.cn/software.php ).

  20. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1993--September 30, 1994

    International Nuclear Information System (INIS)

    Hoppe, M.

    1995-04-01

    On December 30, 1990, the US Department of Energy entered into a contract with General Atomics (GA) to be the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor. During the period, GA was assigned 17 tasks in support of the Inertial Confinement Fusion program and its laboratories. This year they achieved full production capabilities for the micromachining, dimensional characterization and gold plating of hohlraums. They fabricated and delivered 726 gold-plated mandrels of 27 different types to LLNL and 48 gold-plated mandrels of two different types to LANL. They achieved full production capabilities in composite capsule production ad delivered in excess of 240 composite capsules. They continuously work to improve performance and capabilities. They were also directed to dismantle, remove, and disposition all equipment at the previous contractor (KMSF) that had radioactive contamination levels low enough that they could be exposed to the general public without radiological constraints. GA was also directed to receive and store the tritium fill equipment. They assisted LANL in the development of techniques for characterization of opaque targets. They developed deuterated and UV-opaque polymers for use by the University of Rochester's Laboratory for Laser Energetics (UR/LLE) and devised a triple-orifice droplet generator to demonstrate the controlled-mass nature of the microencapsulation process. The ICF program is anticipating experiments at NIF and the Omega Upgrade. Both facilities will require capsules containing layered D 2 or D-T fuel. They continued engineering and assembly of equipment for a cryogenic target handling system for UR/LLE that will fill, transport, layer, and characterize targets filled with cryogenic deuterium or deuterium-tritium fuel, and insert these cryogenic targets into the OMEGA Upgrade target chamber for laser implosion experiments

  1. Fabrication of advanced targets for laser driven nuclear fusion reactions through standard microelectronics technology approaches.

    Czech Academy of Sciences Publication Activity Database

    Picciotto, A.; Crivellari, M.; Bellutti, P.; Barozzi, M.; Kucharik, M.; Krása, Josef; Swidlovsky, A.; Malinowska, A.; Velyhan, Andriy; Ullschmied, Jiří; Margarone, Daniele

    2017-01-01

    Roč. 12, October (2017), č. článku P10001. ISSN 1748-0221 Grant - others:OP VK 2 LaserGen(XE) CZ.1.07/2.3.00/20.0087; LaserZdroj (OP VK 3)(XE) CZ.1.07/2.3.00/20.0279 Institutional support: RVO:61389021 ; RVO:68378271 Keywords : Nuclear instruments and methods for hot plasma diagnostics * Plasma generation (laserproduced, RF, x ray-produced) * Plasma diagnostics - charged-particle spectroscopy Subject RIV: BL - Plasma and Gas Discharge Physics; BL - Plasma and Gas Discharge Physics (FZU-D) OBOR OECD: 2.11 Other engineering and technologies; 2.11 Other engineering and technologies (FZU-D) Impact factor: 1.220, year: 2016 http://iopscience.iop.org/article/10.1088/1748-0221/12/10/P10001/meta

  2. The study of metal-alloy targets and excimer laser deposition technology

    CERN Document Server

    Xu Hua; Tang Yong Jian; Wu Wei Dong; Zhang Ji Cheng

    2002-01-01

    Pulsed Laser Deposition (PLD) technology is described. Design and manufacture of the PLD installation is illustrated in detail. The Cu films and Cu/Fe multi-layers are produced by PLD method. The production of the Mg/Si films using magnetron sputtering method is investigated in detail. The percent of Si on Mg/Si film surface is measured by using conductivity method

  3. Induced mutation and epigenetics modification in plants for crop improvement by targeting CRISPR/Cas9 technology.

    Science.gov (United States)

    Khan, Muhammad Hafeez Ullah; Khan, Shahid U; Muhammad, Ali; Hu, Limin; Yang, Yang; Fan, Chuchuan

    2018-06-01

    Clustered regularly interspaced palindromic repeats associated protein Cas9 (CRISPR-Cas9), originally an adaptive immunity system of prokaryotes, is revolutionizing genome editing technologies with minimal off-targets in the present era. The CRISPR/Cas9 is now highly emergent, advanced, and highly specific tool for genome engineering. The technology is widely used to animal and plant genomes to achieve desirable results. The present review will encompass how CRISPR-Cas9 is revealing its beneficial role in characterizing plant genetic functions, genomic rearrangement, how it advances the site-specific mutagenesis, and epigenetics modification in plants to improve the yield of field crops with minimal side-effects. The possible pitfalls of using and designing CRISPR-Cas9 for plant genome editing are also discussed for its more appropriate applications in plant biology. Therefore, CRISPR/Cas9 system has multiple benefits that mostly scientists select for genome editing in several biological systems. © 2017 Wiley Periodicals, Inc.

  4. Targeting non-coding RNAs in Plants with the CRISPR-Cas technology is a challenge yet worth accepting

    Directory of Open Access Journals (Sweden)

    Jolly eBasak

    2015-11-01

    Full Text Available Non-coding RNAs (ncRNAs have emerged as versatile master regulator of biological functions in recent years. MicroRNAs (miRNAs are small endogenous ncRNAs of 18-24 nucleotides in length that originates from long self-complementary precursors. Besides their direct involvement in developmental processes, plant miRNAs play key roles in gene regulatory networks and varied biological processes. Alternatively, long ncRNAs (lncRNAs are a large and diverse class of transcribed ncRNAs whose length exceed that of 200 nucleotides. Plant lncRNAs are transcribed by different RNA polymerases, showing diverse structural features. Plant lncRNAs also are important regulators of gene expression in diverse biological processes. There has been a breakthrough in the technology of genome editing, the CRISPR-Cas9 (clustered regulatory interspaced short palindromic repeats/CRISPR-associated protein 9 technology, in the last decade. CRISPR loci are transcribed into ncRNA and eventually form a functional complex with Cas9 and further guide the complex to cleave complementary invading DNA. The CRISPR-Cas technology has been successfully applied in model plants such as Arabidopsis and tobacco and important crops like wheat, maize and rice. However, all these studies are focused on protein coding genes. Information about targeting non-coding genes is scarce. Hitherto, the CRISPR-Cas technology has been exclusively used in vertebrate systems to engineer miRNA/lncRNAs, but it is still relatively unexplored in plants. While briefing miRNAs, lncRNAs and applications of the CRISPR-Cas technology in human and animals, this review essentially elaborates several strategies to overcome the challenges of applying the CRISPR-Cas technology in editing ncRNAs in plants and the future perspective of this field.

  5. Strand Invasion Based Amplification (SIBA®): a novel isothermal DNA amplification technology demonstrating high specificity and sensitivity for a single molecule of target analyte.

    Science.gov (United States)

    Hoser, Mark J; Mansukoski, Hannu K; Morrical, Scott W; Eboigbodin, Kevin E

    2014-01-01

    Isothermal nucleic acid amplification technologies offer significant advantages over polymerase chain reaction (PCR) in that they do not require thermal cycling or sophisticated laboratory equipment. However, non-target-dependent amplification has limited the sensitivity of isothermal technologies and complex probes are usually required to distinguish between non-specific and target-dependent amplification. Here, we report a novel isothermal nucleic acid amplification technology, Strand Invasion Based Amplification (SIBA). SIBA technology is resistant to non-specific amplification, is able to detect a single molecule of target analyte, and does not require target-specific probes. The technology relies on the recombinase-dependent insertion of an invasion oligonucleotide (IO) into the double-stranded target nucleic acid. The duplex regions peripheral to the IO insertion site dissociate, thereby enabling target-specific primers to bind. A polymerase then extends the primers onto the target nucleic acid leading to exponential amplification of the target. The primers are not substrates for the recombinase and are, therefore unable to extend the target template in the absence of the IO. The inclusion of 2'-O-methyl RNA to the IO ensures that it is not extendible and that it does not take part in the extension of the target template. These characteristics ensure that the technology is resistant to non-specific amplification since primer dimers or mis-priming are unable to exponentially amplify. Consequently, SIBA is highly specific and able to distinguish closely-related species with single molecule sensitivity in the absence of complex probes or sophisticated laboratory equipment. Here, we describe this technology in detail and demonstrate its use for the detection of Salmonella.

  6. Strand Invasion Based Amplification (SIBA®: a novel isothermal DNA amplification technology demonstrating high specificity and sensitivity for a single molecule of target analyte.

    Directory of Open Access Journals (Sweden)

    Mark J Hoser

    Full Text Available Isothermal nucleic acid amplification technologies offer significant advantages over polymerase chain reaction (PCR in that they do not require thermal cycling or sophisticated laboratory equipment. However, non-target-dependent amplification has limited the sensitivity of isothermal technologies and complex probes are usually required to distinguish between non-specific and target-dependent amplification. Here, we report a novel isothermal nucleic acid amplification technology, Strand Invasion Based Amplification (SIBA. SIBA technology is resistant to non-specific amplification, is able to detect a single molecule of target analyte, and does not require target-specific probes. The technology relies on the recombinase-dependent insertion of an invasion oligonucleotide (IO into the double-stranded target nucleic acid. The duplex regions peripheral to the IO insertion site dissociate, thereby enabling target-specific primers to bind. A polymerase then extends the primers onto the target nucleic acid leading to exponential amplification of the target. The primers are not substrates for the recombinase and are, therefore unable to extend the target template in the absence of the IO. The inclusion of 2'-O-methyl RNA to the IO ensures that it is not extendible and that it does not take part in the extension of the target template. These characteristics ensure that the technology is resistant to non-specific amplification since primer dimers or mis-priming are unable to exponentially amplify. Consequently, SIBA is highly specific and able to distinguish closely-related species with single molecule sensitivity in the absence of complex probes or sophisticated laboratory equipment. Here, we describe this technology in detail and demonstrate its use for the detection of Salmonella.

  7. Use of CRISPR/Cas Genome Editing Technology for Targeted Mutagenesis in Rice.

    Science.gov (United States)

    Xu, Rongfang; Wei, Pengcheng; Yang, Jianbo

    2017-01-01

    Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas) system is a newly emerging mutagenesis (gene-editing) tool in genetic engineering. Among the agriculturally important crops, several genes have been successfully mutated by the system, and some agronomic important traits have been rapidly generated, which indicates the potential applications in both scientific research and plant breeding. In this chapter, we describe a standard gene-editing procedure to effectively target rice genes and to make specific rice mutants using the CRISPR/Cas9 system mediated by Agrobacterium transformation.

  8. PEAK SHAVING CONSIDERING STREAMFLOW UNCERTAINTIES

    African Journals Online (AJOL)

    user

    Abstract. The main thrust of this paper is peak shaving with a Stochastic hydro model. In peak sharing, the amount of hydro energy scheduled may be a minimum but it serves to replace less efficient thermal units. The sample system is die Kainji hydro plant and the thermal units of the National Electric. Power Authority.

  9. Twin and triple peaks papilledema.

    Science.gov (United States)

    Mehta, Jodhbir S; Plant, Gordon T; Acheson, James F

    2005-07-01

    To describe 2 adult patients who presented with papilledema after band atrophy (i.e., twin and triple peaks papilledema). Retrospective small case series. Two outpatients. Observations made on 2 patients whose cases were reviewed in the neuro-ophthalmology clinic. The first patient had a pituitary tumor presenting with papilledema, causing a triple peaks clinical sign. Color photographs, optical coherence tomograms, and magnetic resonance images are shown. The second patient developed twin peaks papilledema due to a chiasmal glioma causing secondary raised intracranial pressure. Twin peaks papilledema is a rare clinical sign that may develop in adults as well as in children. The first report and optical coherence tomography features of triple peaks papilledema illustrate a new clinical sign.

  10. Research on Key Technologies of Network Centric System Distributed Target Track Fusion

    Directory of Open Access Journals (Sweden)

    Yi Mao

    2017-01-01

    Full Text Available To realize common tactical picture in network-centered system, this paper proposes a layered architecture for distributed information processing and a method for distributed track fusion on the basis of analyzing the characteristics of network-centered systems. Basing on the noncorrelation of three-dimensional measurement of surveillance and reconnaissance sensors under polar coordinates, it also puts forward an algorithm for evaluating track quality (TQ using statistical decision theory. According to simulation results, the TQ value is associated with the measurement accuracy of sensors and the motion state of targets, which is well matched with the convergence process of tracking filters. Besides, the proposed algorithm has good reliability and timeliness in track quality evaluation.

  11. Development of low enrichment technologies for high density fuels and for isotope production targets

    International Nuclear Information System (INIS)

    Taboada, Horacio; Gonzalez, Alfredo G.

    2005-01-01

    Since more than twenty years ago, CNEA has carried out RERTR activities. Main goals are to convert the RA 6 reactor core from HEU to LEU, to get a comprehensive understanding of U-Mo/Al compounds phase formation in dispersed and monolithic fuels, to develop possible solutions to VHD dispersed and monolithic fuels technical problems, and to optimize techniques to recover U from silicide scrap samples. The future plans include: 1) Completion the RA 6 reactor conversion to LEU; 2) Qualification by irradiation of the promising solutions found for the high density fuels; 3) Irradiation of mini plates and full scale fuel assemblies at the RA 3 reactor and at higher flux and temperature reactors; 4) Optimization of LEU target and radiochemical techniques for radioisotope production. (author) [es

  12. Construction of Target Controllable Image Segmentation Model Based on Homotopy Perturbation Technology

    Directory of Open Access Journals (Sweden)

    Shu-Li Mei

    2013-01-01

    Full Text Available Based on the basic idea of the homotopy perturbation method which was proposed by Jihuan He, a target controllable image segmentation model and the corresponding multiscale wavelet numerical method are constructed. Using the novel model, we can get the only right object from the multiobject images, which is helpful to avoid the oversegmentation and insufficient segmentation. The solution of the variational model is the nonlinear PDEs deduced by the variational approach. So, the bottleneck of the variational model on image segmentation is the lower efficiency of the algorithm. Combining the multiscale wavelet interpolation operator and HPM, a semianalytical numerical method can be obtained, which can improve the computational efficiency and accuracy greatly. The numerical results on some images segmentation show that the novel model and the numerical method are effective and practical.

  13. Improving medication adherence with a targeted, technology-driven disease management intervention.

    Science.gov (United States)

    Lawrence, David B; Allison, Wanda; Chen, Joyce C; Demand, Michael

    2008-06-01

    Treatment adherence is critical in managing chronic disease, but achieving it remains an elusive goal across many prevalent conditions. As part of its care management strategy, BlueCross BlueShield of South Carolina (BCBSSC) implemented the Longitudinal Adherence Treatment Evaluation program, a behavioral intervention to improve medication adherence among members with cardiovascular disease and/or diabetes. The objectives of this study were to 1) assess the effectiveness of telephonic intervention in influencing reinitiation of medication therapy, and 2) evaluate the rate and timing of medication reinitiation. BCBSSC applied algorithms against pharmacy claims data to identify patients prescribed targeted medications who were 60 or more days overdue for refills. This information was provided to care managers to address during their next patient contact. Care managers received focused training on techniques for medication behavior change, readiness to change, motivational interviewing, and active listening. Training also addressed common barriers to adherence and available resources, including side effect management, mail order benefits, drug assistance programs, medication organizers, and reminder systems. Overdue refills were tracked for 12 months, with medication reinitiation followed for an additional 3 months. In the intervention group, 94 patients were identified with 123 instances of late medication refills. In the age- and gender-matched comparison group, 61 patients were identified with 76 late refills. The intervention group had a significantly higher rate of medication reinitiation (59.3%) than the control group (42.1%; P < 0.05). Time to reinitiation was significantly shorter in the intervention group, 59.5 (+/- 69.0) days vs. 107.4 (+/- 109) days for the control group (P < 0.05). This initiative demonstrated that a targeted disease management intervention promoting patient behavior change increased the number of patients who reinitiated therapy after a

  14. A new peptide ligand for targeting human carbonic anhydrase IX, identified through the phage display technology.

    Directory of Open Access Journals (Sweden)

    Vasileios Askoxylakis

    2010-12-01

    Full Text Available Carbonic anhydrase IX (CAIX is a transmembrane enzyme found to be overexpressed in various tumors and associated with tumor hypoxia. Ligands binding this target may be used to visualize hypoxia, tumor manifestation or treat tumors by endoradiotherapy.Phage display was performed with a 12 amino acid phage display library by panning against a recombinant extracellular domain of human carbonic anhydrase IX. The identified peptide CaIX-P1 was chemically synthesized and tested in vitro on various cell lines and in vivo in Balb/c nu/nu mice carrying subcutaneously transplanted tumors. Binding, kinetic and competition studies were performed on the CAIX positive human renal cell carcinoma cell line SKRC 52, the CAIX negative human renal cell carcinoma cell line CaKi 2, the human colorectal carcinoma cell line HCT 116 and on human umbilical vein endothelial cells (HUVEC. Organ distribution studies were carried out in mice, carrying SKRC 52 tumors. RNA expression of CAIX in HCT 116 and HUVEC cells was investigated by quantitative real time PCR.In vitro binding experiments of (125I-labeled-CaIX-P1 revealed an increased uptake of the radioligand in the CAIX positive renal cell carcinoma cell line SKRC 52. Binding of the radioligand in the colorectal carcinoma cell line HCT 116 increased with increasing cell density and correlated with the mRNA expression of CAIX. Radioligand uptake was inhibited up to 90% by the unlabeled CaIX-P1 peptide, but not by the negative control peptide octreotide at the same concentration. No binding was demonstrated in CAIX negative CaKi 2 and HUVEC cells. Organ distribution studies revealed a higher accumulation in SKRC 52 tumors than in heart, spleen, liver, muscle, intestinum and brain, but a lower uptake compared to blood and kidney.These data indicate that CaIX-P1 is a promising candidate for the development of new ligands targeting human carbonic anhydrase IX.

  15. Technology-Based Innovations to Foster Personalized Healthy Lifestyles and Well-Being: A Targeted Review

    Science.gov (United States)

    Santana, Silvina; Tsiknakis, Manolis; Marias, Kostas; Sakkalis, Vangelis; Teixeira, António; Janssen, Joris H; de Jong, Henri; Tziraki, Chariklia

    2016-01-01

    Background New community-based arrangements and novel technologies can empower individuals to be active participants in their health maintenance, enabling people to control and self-regulate their health and wellness and make better health- and lifestyle-related decisions. Mobile sensing technology and health systems responsive to individual profiles combined with cloud computing can expand innovation for new types of interoperable services that are consumer-oriented and community-based. This could fuel a paradigm shift in the way health care can be, or should be, provided and received, while lessening the burden on exhausted health and social care systems. Objective Our goal is to identify and discuss the main scientific and engineering challenges that need to be successfully addressed in delivering state-of-the-art, ubiquitous eHealth and mHealth services, including citizen-centered wellness management services, and reposition their role and potential within a broader context of diverse sociotechnical drivers, agents, and stakeholders. Methods We review the state-of-the-art relevant to the development and implementation of eHealth and mHealth services in critical domains. We identify and discuss scientific, engineering, and implementation-related challenges that need to be overcome to move research, development, and the market forward. Results Several important advances have been identified in the fields of systems for personalized health monitoring, such as smartphone platforms and intelligent ubiquitous services. Sensors embedded in smartphones and clothes are making the unobtrusive recognition of physical activity, behavior, and lifestyle possible, and thus the deployment of platforms for health assistance and citizen empowerment. Similarly, significant advances are observed in the domain of infrastructure supporting services. Still, many technical problems remain to be solved, combined with no less challenging issues related to security, privacy, trust, and

  16. Technology-Based Innovations to Foster Personalized Healthy Lifestyles and Well-Being: A Targeted Review.

    Science.gov (United States)

    Spanakis, Emmanouil G; Santana, Silvina; Tsiknakis, Manolis; Marias, Kostas; Sakkalis, Vangelis; Teixeira, António; Janssen, Joris H; de Jong, Henri; Tziraki, Chariklia

    2016-06-24

    New community-based arrangements and novel technologies can empower individuals to be active participants in their health maintenance, enabling people to control and self-regulate their health and wellness and make better health- and lifestyle-related decisions. Mobile sensing technology and health systems responsive to individual profiles combined with cloud computing can expand innovation for new types of interoperable services that are consumer-oriented and community-based. This could fuel a paradigm shift in the way health care can be, or should be, provided and received, while lessening the burden on exhausted health and social care systems. Our goal is to identify and discuss the main scientific and engineering challenges that need to be successfully addressed in delivering state-of-the-art, ubiquitous eHealth and mHealth services, including citizen-centered wellness management services, and reposition their role and potential within a broader context of diverse sociotechnical drivers, agents, and stakeholders. We review the state-of-the-art relevant to the development and implementation of eHealth and mHealth services in critical domains. We identify and discuss scientific, engineering, and implementation-related challenges that need to be overcome to move research, development, and the market forward. Several important advances have been identified in the fields of systems for personalized health monitoring, such as smartphone platforms and intelligent ubiquitous services. Sensors embedded in smartphones and clothes are making the unobtrusive recognition of physical activity, behavior, and lifestyle possible, and thus the deployment of platforms for health assistance and citizen empowerment. Similarly, significant advances are observed in the domain of infrastructure supporting services. Still, many technical problems remain to be solved, combined with no less challenging issues related to security, privacy, trust, and organizational dynamics. Delivering

  17. Exploration and reservoir characterization; Technology Target Areas; TTA2 - Exploration and reservoir characterisation

    Energy Technology Data Exchange (ETDEWEB)

    2008-07-01

    In future, research within exploration and reservoir characterization will play an even more important role for Norway since resources are decreasing and new challenges like deep sea, harsh environment and last but not least environmental issues have to be considered. There are two major fields which have to be addressed within exploration and reservoir characterization: First, replacement of reserves by new discoveries and ultimate field recoveries in mature basins at the Norwegian Continental shelf, e.g. at the Halten Terrace has to be addressed. A wealth of data exists in the more mature areas. Interdisciplinary integration is a key feature of reservoir characterization, where available data and specialist knowledge need to be combined into a consistent reservoir description. A systematic approach for handling both uncertainties in data sources and uncertainties in basic models is needed. Fast simulation techniques are necessary to generate models spanning the event space, covering both underground based and model-based uncertainties. Second, exploration in frontier areas like the Barents Sea region and the deeper Voering Basin has to be addressed. The scarcity of wells in these frontier areas leads to uncertainties in the geological understanding. Basin- and depositional modelling are essential for predicting where source rocks and reservoir rocks are deposited, and if, when and which hydrocarbons are generated and trapped. Predictive models and improved process understanding is therefore crucial to meet these issues. Especially the challenges related to the salt deposits e.g. sub-salt/sub-basalt reservoir definitions in the Nordkapp Basin demands up-front research and technology developments. TTA2 stresses the need to focus on the development of new talents. We also see a strong need to push cooperation as far as possible in the present competitive environment. Projects that may require a substantial financial commitment have been identified. The following

  18. Solubility of helium in mercury for bubbling technology of the spallation neutron mercury target

    International Nuclear Information System (INIS)

    Hasegawa, S.; Naoe, T.; Futakawa, M.

    2010-01-01

    The pitting damage of mercury target container that originates in the pressure wave excited by the proton beam incidence becomes a large problem to reach the high-power neutron source in JSNS and SNS. The lifetime of mercury container is decreased remarkably by the pitting damage. As one of solutions, the pressure wave is mitigated by injecting the helium micro bubbles in mercury. In order to inject the helium micro bubbles into mercury, it is important to understand the characteristic of micro bubbles in mercury. The solubility of mercury-helium system is a key factor to decide bubbling conditions, because the disappearance behavior, i.e. the lifetime of micro bubbles, depends on the solubility. In addition, the bubble generation method is affected by it. Moreover, the experimental data related to the solubility of helium in mercury hardly exist. In this work, the solubility was obtained experimentally by measuring precisely the pressure drop of the gas that is facing to mercury surface. The pressure drop was attributed to the helium dissolution into mercury. Based on the measured solubility, the lifetime of micro bubbles and the method of the bubble generation is estimated using the solubility data.

  19. MEANING OF TARGET AMBIGUITY FACTOR IN INTELLECTUAL TECHNOLOGIES OF SCIENTIFIC SEARCH

    Directory of Open Access Journals (Sweden)

    V. M. Коleshko

    2008-01-01

    Full Text Available The main peculiar feature of an intellectual system orientated to formulation of original scientific hypothesis, non-trivial technical solutions is an initial target ambiguity of creative search. Process concerning creation of new knowledge in such system presuppose chaotic steps directed on hypothesis synthesis and their improvement, cancellation of non-productive searching methods and advancement of new scientific theories. Formation of new knowledge which generally has random character at the initial stage gradually becomes more ordered, motivated to obtain a concrete result due to development of searching process. Both components of the intellectual medium (a human being and a machine have so to speak an equilibrium in their actions, actively interacting and supplementing each other in the most creative procedures of hypothesis synthesis. Role difference resides in that a computer provides its formal logical and information resource for solution selection, and a researcher is assigned to carry out an additional task that is to take decisions about correctness of scientific hypothesis

  20. Measuring Your Peak Flow Rate

    Science.gov (United States)

    ... your child so they can help monitor your child's asthma symptoms . Why Should I Measure My Flow Rate? ... help parents determine what might be triggering their child's asthma. How Do You Use a Peak Flow Meter? ...

  1. Ultrasonic Transducer Peak-to-Peak Optical Measurement

    Directory of Open Access Journals (Sweden)

    Pavel Skarvada

    2012-01-01

    Full Text Available Possible optical setups for measurement of the peak-to-peak value of an ultrasonic transducer are described in this work. The Michelson interferometer with the calibrated nanopositioner in reference path and laser Doppler vibrometer were used for the basic measurement of vibration displacement. Langevin type of ultrasonic transducer is used for the purposes of Electro-Ultrasonic Nonlinear Spectroscopy (EUNS. Parameters of produced mechanical vibration have to been well known for EUNS. Moreover, a monitoring of mechanical vibration frequency shift with a mass load and sample-transducer coupling is important for EUNS measurement.

  2. Chinese emissions peak: Not when, but how

    International Nuclear Information System (INIS)

    Spencer, Thomas; Colombier, Michel; Wang, Xin; Sartor, Oliver; Waisman, Henri

    2016-07-01

    It seems highly likely that China will overachieve its 2020 and 2030 targets, and peak its emissions before 2030 and possibly at a lower level than often assumed. This paper argues that the debate on the timing of the peak is misplaced: what matters is not when by why. For the peak to be seen as a harbinger of deep transformation, it needs to be based on significant macro-economic reform and restructuring, with attendant improvement in energy intensity. The Chinese economic model has been extraordinarily investment and resource intensive, and has driven the growth in GHG emissions. That model is no longer economically or environmentally sustainable. Therefore Chinese policy-makers are faced with a trade-off between slower short-term growth and economic reform, versus supporting short-term growth but slowing economic reform. The outcome will be crucial for the transition to a low-carbon economy. Overall, the 13. FYP (2016-2020) gives the impression of a cautious reflection of the new normal paradigm on the economic front, and a somewhat conservative translation of this shift into the energy and climate targets. Nonetheless, the 13. FYP targets set China well on the way to overachieving its 2020 pledge undertaken at COP15 in Copenhagen, and to potentially overachieving its INDC. It thus seems likely that China will achieve its emissions peak before 2030. However, the crucial question is not when China peaks, but whether the underlying transformation of the Chinese economy and energy system lays the basis for deep decarbonization thereafter. Thorough assessments of the implications of the 'new normal' for Chinese emissions and energy system trajectories, taking into account the link with the Chinese macro-economy, are needed. Scenarios provide a useful framework and should focus on a number of short-term uncertainties. Most energy system and emissions scenarios published today assume a continuity of trends between 2010-2015 and 2015-2020, which is at odds

  3. European Union clean coal technologies. Guide on EC financial support for EU clean coal technology projects outside the EU in the target market

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-11

    This guide is one of the actions following from the recommendations of the Thermie B project that aimed to support the development of a new European Integrated Clean Coal (CCT) Program concept (STR - 1121 - 96), November 1998. The concept aimed to enhance the market deployment of EU CCTs. This guide is prepared for EU industry to help them finding support for their CCT exports to the target markets. The guide will include easy accessible information on the most relevant EC-programs and is intended as a practical tool for EU CCT industry, to assist them in identifying and selecting the export support and programs best able to support their specific export assistance. The guide is a manual (signpost) through the 'jungle of assistance' and therefore does not include extensive information on application procedures, since this kind of information can be easily obtained, once the relevant program is identified. Also information will be presented on EU Export Credit Agencies and some relevant bilateral and multilateral financing institutions. Two remarks have to be made: (1) Subsidies and financial instruments are continuously subject to change. Therefore it is advised to contact the institutes and organisations for up-to-date information. The addresses and web sites for information and updates can also be found in this guide; and (2) This guide will not present a complete overview of all subsidies and financial instruments available. A selection is made based on relevancy to exporters of Clean Coal Technologies to target markets, such as China, India, Indonesia, Thailand, Poland and the Czech Republic. The list of subsidies, instruments and financial institutions presented in this guide is not exhaustive.

  4. New View of Twin Peaks Region

    Science.gov (United States)

    1997-01-01

    This image taken on Sol 74 ( September 17) from the Sojourner rover's right front camera shows areas of the Pathfinder landing site never before seen. The shadow of the rover and its antenna is visible in the foreground. On the horizon at right are the Twin Peaks, about 1 kilometer away.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech).

  5. Managing peak loads in energy grids: Comparative economic analysis

    International Nuclear Information System (INIS)

    Zhuk, A.; Zeigarnik, Yu.; Buzoverov, E.; Sheindlin, A.

    2016-01-01

    One of the key issues in modern energy technology is managing the imbalance between the generated power and the load, particularly during times of peak demand. The increasing use of renewable energy sources makes this problem even more acute. Various existing technologies, including stationary battery energy storage systems (BESS), can be employed to provide additional power during peak demand times. In the future, integration of on-board batteries of the growing fleet of electric vehicles (EV) and plug-in hybrid electric vehicles (PHEV) into the grid can provide power during peak demand hours (vehicle-to-grid, or V2G technology). This work provides cost estimates of managing peak energy demands using traditional technologies, such as maneuverable power plants, conventional hydroelectric, pumped storage plants and peaker generators, as well as BESS and V2G technologies. The derived estimates provide both per kWh and kW year of energy supplied to the grid. The analysis demonstrates that the use of battery storage is economically justified for short peak demand periods of <1 h. For longer durations, the most suitable technology remains the use of maneuverable steam gas power plants, gas turbine,reciprocating gas engine peaker generators, conventional hydroelectric, pumped storage plants. - Highlights: • Cost of managing peak energy demand employing different technologies are estimated. • Traditional technologies, stationary battery storage and V2G are compared. • Battery storage is economically justified for peak demand periods of <1 h. • V2G appears to have better efficiency than stationary battery storage in low voltage power grids.

  6. Gamma-Ray Peak Integration: Accuracy and Precision

    International Nuclear Information System (INIS)

    Richard M. Lindstrom

    2000-01-01

    The accuracy of singlet gamma-ray peak areas obtained by a peak analysis program is immaterial. If the same algorithm is used for sample measurement as for calibration and if the peak shapes are similar, then biases in the integration method cancel. Reproducibility is the only important issue. Even the uncertainty of the areas computed by the program is trivial because the true standard uncertainty can be experimentally assessed by repeated measurements of the same source. Reproducible peak integration was important in a recent standard reference material certification task. The primary tool used for spectrum analysis was SUM, a National Institute of Standards and Technology interactive program to sum peaks and subtract a linear background, using the same channels to integrate all 20 spectra. For comparison, this work examines other peak integration programs. Unlike some published comparisons of peak performance in which synthetic spectra were used, this experiment used spectra collected for a real (though exacting) analytical project, analyzed by conventional software used in routine ways. Because both components of the 559- to 564-keV doublet are from 76 As, they were integrated together with SUM. The other programs, however, deconvoluted the peaks. A sensitive test of the fitting algorithm is the ratio of reported peak areas. In almost all the cases, this ratio was much more variable than expected from the reported uncertainties reported by the program. Other comparisons to be reported indicate that peak integration is still an imperfect tool in the analysis of gamma-ray spectra

  7. Tim Peake and Britain's road to space

    CERN Document Server

    Seedhouse, Erik

    2017-01-01

    This book puts the reader in the flight suit of Britain’s first male astronaut, Tim Peake. It chronicles his life, along with the Principia mission and the down-to-the-last-bolt descriptions of life aboard the ISS, by way of the hurdles placed by the British government and the rigors of training at Russia’s Star City military base. In addition, this book discusses the learning curves required in astronaut and mission training and the complexity of the technologies required to launch an astronaut and keep them alive for months on end. This book underscores the fact that technology and training, unlike space, do not exist in a vacuum; complex technical systems, like the ISS, interact with the variables of human personality, and the cultural background of the astronauts. .

  8. Neurofeedback training for peak performance

    OpenAIRE

    Marek Graczyk; Maria Pąchalska; Artur Ziółkowski; Grzegorz Mańko; Beata Łukaszewska; Kazimierz Kochanowicz; Andrzej Mirski; Iurii D. Kropotov

    2014-01-01

    [b]aim[/b]. One of the applications of the Neurofeedback methodology is peak performance in sport. The protocols of the neurofeedback are usually based on an assessment of the spectral parameters of spontaneous EEG in resting state conditions. The aim of the paper was to study whether the intensive neurofeedback training of a well-functioning Olympic athlete who has lost his performance confidence after injury in sport, could change the brain functioning reflected in changes in spontaneou...

  9. Feeling validated yet? A scoping review of the use of consumer-targeted wearable and mobile technology to measure and improve sleep.

    Science.gov (United States)

    Baron, Kelly Glazer; Duffecy, Jennifer; Berendsen, Mark A; Cheung Mason, Ivy; Lattie, Emily G; Manalo, Natalie C

    2017-12-20

    The objectives of this review were to evaluate the use of consumer-targeted wearable and mobile sleep monitoring technology, identify gaps in the literature and determine the potential for use in behavioral interventions. We undertook a scoping review of studies conducted in adult populations using consumer-targeted wearable technology or mobile devices designed to measure and/or improve sleep. After screening for inclusion/exclusion criteria, data were extracted from the articles by two co-authors. Articles included in the search were using wearable or mobile technology to estimate or evaluate sleep, published in English and conducted in adult populations. Our search returned 3897 articles and 43 met our inclusion criteria. Results indicated that the majority of studies focused on validating technology to measure sleep (n = 23) or were observational studies (n = 10). Few studies were used to identify sleep disorders (n = 2), evaluate response to interventions (n = 3) or deliver interventions (n = 5). In conclusion, the use of consumer-targeted wearable and mobile sleep monitoring technology has largely focused on validation of devices and applications compared with polysomnography (PSG) but opportunities exist for observational research and for delivery of behavioral interventions. Multidisciplinary research is needed to determine the uses of these technologies in interventions as well as the use in more diverse populations including sleep disorders and other patient populations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animals.

    Science.gov (United States)

    Arkhipov, Ivan A; Sadov, Konstantin M; Limova, Yulia V; Sadova, Alexandra K; Varlamova, Anastasiya I; Khalikov, Salavat S; Dushkin, Alexandr V; Chistyachenko, Yulia S

    2017-11-15

    Niclosamide is an anthelmintic that is widely used to treat cestode infection of animals. The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery was studied in hymenolepiosis of mice and monieziosis of sheep. The efficacy of new substances of niclosamide with polyvinylpyrrolidone polymer in different ratios (1:10; 1:5; 1:2) was determined by the results of helminthological necropsy of the small intestine of sheep and mice. Pre-treatment eggs per gram (EPG) were not significantly different (P>0.1) among groups. The controlled test was used to evaluate the efficacy. A high efficacy (>95% efficacy) of the supramolecular complexes of niclosamide with PVP (SCoNwPVP) was shown in different ratios (1:10; 1:5 and 1:2) at a dose of 20mg/kg of body weight at oral administration against Hymenolepis nana in mice and Moniezia expansa in sheep. Whereas the basic drug - substance of niclosamide was effective at a dose of 100mg/kg of b/w. No adverse effects of the drugs on animal health were detected during the study. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Drivers of peak sales for pharmaceutical brands

    NARCIS (Netherlands)

    Fischer, Marc; Leeflang, Peter S. H.; Verhoef, Peter C.

    2010-01-01

    Peak sales are an important metric in the pharmaceutical industry. Specifically, managers are focused on the height-of-peak-sales and the time required achieving peak sales. We analyze how order of entry and quality affect the level of peak sales and the time-to-peak-sales of pharmaceutical brands.

  12. Clearing the fog of anticancer patents from 1993-2013: through an in-depth technology landscape & target analysis from pioneer research institutes and universities worldwide.

    Science.gov (United States)

    Dara, Ajay; Sangamwar, Abhay T

    2014-01-01

    In a search for an effective anticancer therapy the R&D units from leading universities and institutes reveal numerous technologies in the form of patent documents. The article addressed comparative anticancer patent landscape and technology assessment of Council of Scientific and Industrial Research (CSIR): India's largest R&D organisation with top twenty international public funded universities and institutes from eight different countries. The methodology include quantitative and qualitative assessment based on the bibliometric parameters and manual technology categorisation to understand the changing patent trends and recent novel technologies. The research finding analysed 25,254 patent documents from the year 1993 to 2013 and reported the insights of latest anticancer technologies and targets through categorisation studies at the level of drug discovery, development and treatment & diagnosis. The article has reported the technology correlation matrix of twelve secondary class technologies with 34 tertiary sub-class research area to identify the leading technologies and scope of future research through whitespaces analysis. In addition, the results have also addressed the target analysis, leading inventor, assignee, collaboration network, geographical distribution, patent trend analysis, citation maps and technology assessment with respect to international patent classification systems such as CPC, IPC and CPI codes. The result suggested peptide technology as the dominating research area next to gene therapy, vaccine and medical preparation containing organic compounds. The Indian CSIR has ranked itself at seventh position among the top 20 universities. Globally, the anticancer research was focused in the area of genetics and immunology, whereas Indian CSIR reported more patents related to plant extract and organic preparation. The article provided a glimpse of two decade anticancer scenario with respect to top public funded universities worldwide.

  13. Clearing the fog of anticancer patents from 1993-2013: through an in-depth technology landscape & target analysis from pioneer research institutes and universities worldwide.

    Directory of Open Access Journals (Sweden)

    Ajay Dara

    Full Text Available BACKGROUND: In a search for an effective anticancer therapy the R&D units from leading universities and institutes reveal numerous technologies in the form of patent documents. The article addressed comparative anticancer patent landscape and technology assessment of Council of Scientific and Industrial Research (CSIR: India's largest R&D organisation with top twenty international public funded universities and institutes from eight different countries. METHODOLOGY/PRINCIPAL FINDINGS: The methodology include quantitative and qualitative assessment based on the bibliometric parameters and manual technology categorisation to understand the changing patent trends and recent novel technologies. The research finding analysed 25,254 patent documents from the year 1993 to 2013 and reported the insights of latest anticancer technologies and targets through categorisation studies at the level of drug discovery, development and treatment & diagnosis. The article has reported the technology correlation matrix of twelve secondary class technologies with 34 tertiary sub-class research area to identify the leading technologies and scope of future research through whitespaces analysis. In addition, the results have also addressed the target analysis, leading inventor, assignee, collaboration network, geographical distribution, patent trend analysis, citation maps and technology assessment with respect to international patent classification systems such as CPC, IPC and CPI codes. CONCLUSIONS/SIGNIFICANCE: The result suggested peptide technology as the dominating research area next to gene therapy, vaccine and medical preparation containing organic compounds. The Indian CSIR has ranked itself at seventh position among the top 20 universities. Globally, the anticancer research was focused in the area of genetics and immunology, whereas Indian CSIR reported more patents related to plant extract and organic preparation. The article provided a glimpse of two decade

  14. Clearing the Fog of Anticancer Patents from 1993–2013: Through an In-Depth Technology Landscape & Target Analysis from Pioneer Research Institutes and Universities Worldwide

    Science.gov (United States)

    Dara, Ajay; Sangamwar, Abhay T.

    2014-01-01

    Background In a search for an effective anticancer therapy the R&D units from leading universities and institutes reveal numerous technologies in the form of patent documents. The article addressed comparative anticancer patent landscape and technology assessment of Council of Scientific and Industrial Research (CSIR): India’s largest R&D organisation with top twenty international public funded universities and institutes from eight different countries. Methodology/Principal Findings The methodology include quantitative and qualitative assessment based on the bibliometric parameters and manual technology categorisation to understand the changing patent trends and recent novel technologies. The research finding analysed 25,254 patent documents from the year 1993 to 2013 and reported the insights of latest anticancer technologies and targets through categorisation studies at the level of drug discovery, development and treatment & diagnosis. The article has reported the technology correlation matrix of twelve secondary class technologies with 34 tertiary sub-class research area to identify the leading technologies and scope of future research through whitespaces analysis. In addition, the results have also addressed the target analysis, leading inventor, assignee, collaboration network, geographical distribution, patent trend analysis, citation maps and technology assessment with respect to international patent classification systems such as CPC, IPC and CPI codes. Conclusions/Significance The result suggested peptide technology as the dominating research area next to gene therapy, vaccine and medical preparation containing organic compounds. The Indian CSIR has ranked itself at seventh position among the top 20 universities. Globally, the anticancer research was focused in the area of genetics and immunology, whereas Indian CSIR reported more patents related to plant extract and organic preparation. The article provided a glimpse of two decade anticancer scenario

  15. Improvements to science operations at Kitt Peak National Observatory

    Science.gov (United States)

    Bohannan, Bruce

    1998-07-01

    In recent years Kitt Peak National Observatory has undertaken a number of innovative projects to optimize science operations with the suite of telescopes we operate on Kitt Peak, Arizona. Changing scientific requirements and expectations of our users, evolving technology and declining budgets have motivated the changes. The operations improvements have included telescope performance enhancements--with the focus on the Mayall 4-m--modes of observing and scheduling, telescope control and observing systems, planning and communication, and data archiving.

  16. The impact of technology availability on the timing and costs of emission reductions for achieving long-term climate targets

    NARCIS (Netherlands)

    van Vliet, J.; Hof, Andries|info:eu-repo/dai/nl/240412397; Mendoza Beltran, A.; van den Berg, M..; Deetman, S.; den Elzen, M.G.J.; Lucas, P.L.; van Vuuren, D.P.|info:eu-repo/dai/nl/11522016X

    2014-01-01

    While most long-term mitigation scenario studies build on a broad portfolio of mitigation technologies, there is quite some uncertainty about the availability and reduction potential of these technologies. This study explores the impacts of technology limitations on greenhouse gas emission

  17. Twin Peaks in 360-degree panorama

    Science.gov (United States)

    1997-01-01

    The prominent hills dubbed 'Twin Peaks' approximately 1-2 kilometers away were imaged by the Imager for Mars Pathfinder (IMP) as part of a 360-degree color panorama, taken over sols 8, 9 and 10. A lander petal and deflated airbag are at the bottom of the image.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.

  18. National energy peak leveling program (NEPLP). Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-12-01

    This three-volume report is responsive to the requirements of contract E (04-3)-1152 to provide a detailed methodology, to include management, technology, and socio-economic aspects, of a voluntary community program for computer-assisted peak load leveling and energy conservation in commercial community facilities. The demonstration project established proof-of-concept in reducing the kW-demand peak by the unofficial goal of 10%, with concurrent kWh savings. The report consists of the following three volumes: Volume I: management overview; Volume II: methodology and technology; and Volume III; appendices.

  19. Sequence based polymorphic (SBP marker technology for targeted genomic regions: its application in generating a molecular map of the Arabidopsis thaliana genome

    Directory of Open Access Journals (Sweden)

    Sahu Binod B

    2012-01-01

    Full Text Available Abstract Background Molecular markers facilitate both genotype identification, essential for modern animal and plant breeding, and the isolation of genes based on their map positions. Advancements in sequencing technology have made possible the identification of single nucleotide polymorphisms (SNPs for any genomic regions. Here a sequence based polymorphic (SBP marker technology for generating molecular markers for targeted genomic regions in Arabidopsis is described. Results A ~3X genome coverage sequence of the Arabidopsis thaliana ecotype, Niederzenz (Nd-0 was obtained by applying Illumina's sequencing by synthesis (Solexa technology. Comparison of the Nd-0 genome sequence with the assembled Columbia-0 (Col-0 genome sequence identified putative single nucleotide polymorphisms (SNPs throughout the entire genome. Multiple 75 base pair Nd-0 sequence reads containing SNPs and originating from individual genomic DNA molecules were the basis for developing co-dominant SBP markers. SNPs containing Col-0 sequences, supported by transcript sequences or sequences from multiple BAC clones, were compared to the respective Nd-0 sequences to identify possible restriction endonuclease enzyme site variations. Small amplicons, PCR amplified from both ecotypes, were digested with suitable restriction enzymes and resolved on a gel to reveal the sequence based polymorphisms. By applying this technology, 21 SBP markers for the marker poor regions of the Arabidopsis map representing polymorphisms between Col-0 and Nd-0 ecotypes were generated. Conclusions The SBP marker technology described here allowed the development of molecular markers for targeted genomic regions of Arabidopsis. It should facilitate isolation of co-dominant molecular markers for targeted genomic regions of any animal or plant species, whose genomic sequences have been assembled. This technology will particularly facilitate the development of high density molecular marker maps, essential for

  20. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1997--September 30, 1998

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, J. [ed.

    1998-12-01

    During this period, General Atomics (GA) and their partner Schafer Corporation were assigned 17 formal tasks in support of the Inertial Confinement Fusion (ICF) program and its five laboratories. A portion of the effort on these tasks included providing direct ``On-site Support`` at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). They fabricated and delivered over 1,200 hohlraum mandrels and numerous other micromachined components to LLNL, LANL, and SNLA. They produced more than 1,300 glass and plastic target capsules for LLNL, LANL, SNLA, and the University of Rochester/Laboratory for Laser Energetics (UR/LLE). They also delivered nearly 2,000 various target foils and films for Naval Research Lab (NRL) and UR/LLE in FY98. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. During FY98, great progress was made by the GA/Schafer-UR/LLE-LANL team in the design, procurement, installation, and testing of the OMEGA Cryogenic Target System (OCTS) that will field cryogenic targets on OMEGA. The design phase was concluded for all components of the OCTS and all major components were procured and nearly all were fabricated. Many of the components were assembled and tested, and some have been shipped to UR/LLE. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D{sub 2} or deuterium-tritium (DT) fuel. They are part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. They also contributed cryogenic support and developed concepts for NIF cryogenic targets. This report summarizes and documents the technical progress made on these tasks.

  1. Inertial confinement fusion target component fabrication and technology development support: Annual report, October 1, 1997 - September 30, 1998

    International Nuclear Information System (INIS)

    Gibson, J.

    1998-12-01

    During this period, General Atomics (GA) and their partner Schafer Corporation were assigned 17 formal tasks in support of the Inertial Confinement Fusion (ICF) program and its five laboratories. A portion of the effort on these tasks included providing direct ''On-site Support'' at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). They fabricated and delivered over 1,200 hohlraum mandrels and numerous other micromachined components to LLNL, LANL, and SNLA. They produced more than 1,300 glass and plastic target capsules for LLNL, LANL, SNLA, and the University of Rochester/Laboratory for Laser Energetics (UR/LLE). They also delivered nearly 2,000 various target foils and films for Naval Research Lab (NRL) and UR/LLE in FY98. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. During FY98, great progress was made by the GA/Schafer-UR/LLE-LANL team in the design, procurement, installation, and testing of the OMEGA Cryogenic Target System (OCTS) that will field cryogenic targets on OMEGA. The design phase was concluded for all components of the OCTS and all major components were procured and nearly all were fabricated. Many of the components were assembled and tested, and some have been shipped to UR/LLE. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D 2 or deuterium-tritium (DT) fuel. They are part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. They also contributed cryogenic support and developed concepts for NIF cryogenic targets. This report summarizes and documents the technical progress made on these tasks

  2. Neurofeedback training for peak performance.

    Science.gov (United States)

    Graczyk, Marek; Pąchalska, Maria; Ziółkowski, Artur; Mańko, Grzegorz; Łukaszewska, Beata; Kochanowicz, Kazimierz; Mirski, Andrzej; Kropotov, Iurii D

    2014-01-01

    One of the applications of the Neurofeedback methodology is peak performance in sport. The protocols of the neurofeedback are usually based on an assessment of the spectral parameters of spontaneous EEG in resting state conditions. The aim of the paper was to study whether the intensive neurofeedback training of a well-functioning Olympic athlete who has lost his performance confidence after injury in sport, could change the brain functioning reflected in changes in spontaneous EEG and event related potentials (ERPs). The case is presented of an Olympic athlete who has lost his performance confidence after injury in sport. He wanted to resume his activities by means of neurofeedback training. His QEEG/ERP parameters were assessed before and after 4 intensive sessions of neurotherapy. Dramatic and statistically significant changes that could not be explained by error measurement were observed in the patient. Neurofeedback training in the subject under study increased the amplitude of the monitoring component of ERPs generated in the anterior cingulate cortex, accompanied by an increase in beta activity over the medial prefrontal cortex. Taking these changes together, it can be concluded that that even a few sessions of neurofeedback in a high performance brain can significantly activate the prefrontal cortical areas associated with increasing confidence in sport performance.

  3. Neurofeedback training for peak performance

    Directory of Open Access Journals (Sweden)

    Marek Graczyk

    2014-11-01

    Full Text Available [b]aim[/b]. One of the applications of the Neurofeedback methodology is peak performance in sport. The protocols of the neurofeedback are usually based on an assessment of the spectral parameters of spontaneous EEG in resting state conditions. The aim of the paper was to study whether the intensive neurofeedback training of a well-functioning Olympic athlete who has lost his performance confidence after injury in sport, could change the brain functioning reflected in changes in spontaneous EEG and event related potentials (ERPs. [b]case study[/b]. The case is presented of an Olympic athlete who has lost his performance confidence after injury in sport. He wanted to resume his activities by means of neurofeedback training. His QEEG/ERP parameters were assessed before and after 4 intensive sessions of neurotherapy. Dramatic and statistically significant changes that could not be explained by error measurement were observed in the patient. [b]conclusion[/b]. Neurofeedback training in the subject under study increased the amplitude of the monitoring component of ERPs generated in the anterior cingulate cortex, accompanied by an increase in beta activity over the medial prefrontal cortex. Taking these changes together, it can be concluded that that even a few sessions of neurofeedback in a high performance brain can significantly activate the prefrontal cortical areas associated with increasing confidence in sport performance.

  4. Measurement of two-peak structure in fusion reaction history

    International Nuclear Information System (INIS)

    Wang Feng; Peng Xiaoshi; Liu Shenye; Liu Yonggang; Xu Tao; Chen Ming; Mei Yu; Kang Dongguo; Gu Jianfa

    2013-01-01

    The relationship of the roughness degree of ablation shell and the two peaks of fusion reaction rate was analyzed. We developed a system for fusion reaction history measurement with high temporal resolution, and applied this system to the SG-Ⅲ prototype for measuring fusion reaction rate. Fusion reaction rate history was measured for the first time with deuterium-tritium filled targets under neutron yields of about 10 10 . We anatomized possible influence factors during fusion reaction rate's measuring. The two peaks of reaction rate can be obtained from the simulation results, and have been confirmed with the experimental results. It is found that neutrons in our experiment are generated by the first peak which is called the shock peak. The simulation and experimental results can provide strong technical support for the research on fusion reaction rate in inertial confinement fusion. (authors)

  5. Demonstration of Advanced Geophysics and Classification Technologies on Munitions Response Sites, Pole Mountain Target and Maneuver Area, Wyoming

    Science.gov (United States)

    2012-03-01

    Characteristic RTK Real Time Kinematic SARA Superfund Amendments and Reauthorization Act SERDP Strategic Environmental Research and Development...and Liability Act of 1980 (CERCLA) as amended by the Superfund Amendments and Reauthorization Act of 1986 ( SARA ); the National Oil and Hazardous...electromagnetic anomalies were selected from the channel 2 gridded data utilizing a peak-picking algorithm ( Blakely test). 2. A grid value cutoff level

  6. Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1996--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, J. [ed.

    1998-03-01

    This report documents the technical activities of the period October 1, 1996 through September 30, 1997. During this period, GA and their partner Schafer Corporation were assigned 13 formal tasks in support of the ICF program and its five laboratories. A portion of the effort on these tasks included providing direct {open_quotes}Onsite Support{close_quotes} at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). Over 700 gold-plated hohlraum mandrels were fabricated and delivered to LLNL, LANL and SNLA. More than 1600 glass and plastic target capsules were produced for LLNL, LANL, SNLA and University of Rochester/Laboratory for Laser Energetics (UR/LLE). Nearly 2000 various target foils and films were delivered for Naval Research Lab (NRL) and UR/LLE in FY97. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D{sub 2} or deuterium-tritium (DT) fuel. This project is part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. During FY97, significant progress was made in the design and component testing of the OMEGA Cryogenic Target System that will field cryogenic targets on OMEGA. This included major design changes, reduction in equipment, and process simplifications. This report summarizes and documents the technical progress made on these tasks.

  7. Inertial confinement fusion target component fabrication and technology development support. Annual report, October 1, 1996 - September 30, 1997

    International Nuclear Information System (INIS)

    Gibson, J.

    1998-03-01

    This report documents the technical activities of the period October 1, 1996 through September 30, 1997. During this period, GA and their partner Schafer Corporation were assigned 13 formal tasks in support of the ICF program and its five laboratories. A portion of the effort on these tasks included providing direct open-quotes Onsite Supportclose quotes at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory Albuquerque (SNLA). Over 700 gold-plated hohlraum mandrels were fabricated and delivered to LLNL, LANL and SNLA. More than 1600 glass and plastic target capsules were produced for LLNL, LANL, SNLA and University of Rochester/Laboratory for Laser Energetics (UR/LLE). Nearly 2000 various target foils and films were delivered for Naval Research Lab (NRL) and UR/LLE in FY97. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D 2 or deuterium-tritium (DT) fuel. This project is part of the National Cryogenic Target Program and support experiments at LLNL and LANL to generate and characterize cryogenic layers for these targets. During FY97, significant progress was made in the design and component testing of the OMEGA Cryogenic Target System that will field cryogenic targets on OMEGA. This included major design changes, reduction in equipment, and process simplifications. This report summarizes and documents the technical progress made on these tasks

  8. Nuclear cooperation targets global challenges. States back main pillars of the IAEA's work to strengthen nuclear safety, verification and technology transfer

    International Nuclear Information System (INIS)

    2000-01-01

    States meeting at the 44th IAEA General Conference in Vienna have set a challenging agenda for international nuclear cooperation into the 21st century that targets issues of global safety, security, and sustainable development. They adopted resolutions endorsing the Agency's programmes for strengthening activities under its three main pillars of work - nuclear verification, safety, and technology - that are closely linked to major challenges before the world. The document presents the main actions taken during the conference

  9. North Twin Peak in super resolution

    Science.gov (United States)

    1997-01-01

    This pair of images shows the result of taking a sequence of 25 identical exposures from the Imager for Mars Pathfinder (IMP) of the northern Twin Peak, with small camera motions, and processing them with the Super-Resolution algorithm developed at NASA's Ames Research Center.The upper image is a representative input image, scaled up by a factor of five, with the pixel edges smoothed out for a fair comparison. The lower image allows significantly finer detail to be resolved.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.The super-resolution research was conducted by Peter Cheeseman, Bob Kanefsky, Robin Hanson, and John Stutz of NASA's Ames Research Center, Mountain View, CA. More information on this technology is available on the Ames Super Resolution home page athttp://ic-www.arc.nasa.gov/ic/projects/bayes-group/ group/super-res/

  10. Households' hourly electricity consumption and peak demand in Denmark

    DEFF Research Database (Denmark)

    Møller Andersen, Frits; Baldini, Mattia; Hansen, Lars Gårn

    2017-01-01

    The electrification of residential energy demand for heating and transportation is expected to increase peak load and require additional generation and transmission capacities. Electrification also provides an opportunity to increase demand response. With a focus on household electricity......, for an individual household, the consumption of each of these technologies roughly doubles the household's consumption and considerably increases their potential for flexibility. Thus, in order to introduce incentives for demand flexibility, while considering reducing peak consumption, policy makers should...... consumption, we analyse the contribution of appliances and new services, such as individual heat pumps and electric vehicles, to peak consumption and the need for demand response incentives to reduce the peak.Initially, the paper presents a new model that represents the hourly electricity consumption profile...

  11. Facility Location with Double-peaked Preferences

    DEFF Research Database (Denmark)

    Filos-Ratsikas, Aris; Li, Minming; Zhang, Jie

    2015-01-01

    We study the problem of locating a single facility on a real line based on the reports of self-interested agents, when agents have double-peaked preferences, with the peaks being on opposite sides of their locations. We observe that double-peaked preferences capture real-life scenarios and thus...... complement the well-studied notion of single-peaked preferences. We mainly focus on the case where peaks are equidistant from the agents’ locations and discuss how our results extend to more general settings. We show that most of the results for single-peaked preferences do not directly apply to this setting...

  12. Targeted nanoparticles for image-guided treatment of triple-negative breast cancer: clinical significance and technological advances.

    Science.gov (United States)

    Miller-Kleinhenz, Jasmine M; Bozeman, Erica N; Yang, Lily

    2015-01-01

    Effective treatment of triple-negative breast cancer (TNBC) with its aggressive tumor biology, highly heterogeneous tumor cells, and poor prognosis requires an integrated therapeutic approach that addresses critical issues in cancer therapy. Multifunctional nanoparticles with the abilities of targeted drug delivery and noninvasive imaging for monitoring drug delivery and responses to therapy, such as theranostic nanoparticles, hold great promise toward the development of novel therapeutic approaches for the treatment of TNBC using a single therapeutic platform. The biological and pathological characteristics of TNBC provide insight into several potential molecular targets for current and future nanoparticle-based therapeutics. Extensive tumor stroma, highly proliferative cells, and a high rate of drug resistance are all barriers that must be appropriately addressed in order for these nanotherapeutic platforms to be effective. Utilization of the enhanced permeability and retention effect coupled with active targeting of cell surface receptors expressed by TNBC cells, and tumor-associated endothelial cells, stromal fibroblasts, and macrophages is likely to overcome such barriers to facilitate more effective drug delivery. An in-depth summary of current studies investigating targeted nanoparticles in preclinical TNBC mouse and human xenograft models is presented. This review aims to outline the current status of nanotherapeutic options for TNBC patients, identification of promising molecular targets, challenges associated with the development of targeted nanotherapeutics, the research done by our group as well as by others, and future perspectives on the nanomedicine field and ways to translate current preclinical studies into the clinic. © 2015 Wiley Periodicals, Inc.

  13. Inertial confinement fusion target component fabrication and technology development support. Annual report 10/1/98 through 9/30/99

    International Nuclear Information System (INIS)

    Gibson, Jane

    1999-01-01

    General Atomics (GA) has served as the Inertial Confinement Fusion (ICF) Target Component Fabrication and Technology Development Support contractor for the U.S. Department of Energy since December 30, 1990. This report documents the technical activities of the period October 1, 1998 through September 30, 1999. During this period, GA and our partner Schafer Corporation were assigned 17 formal tasks in support of the ICF program and its five laboratories. A portion of the effort on these tasks included providing direct ''Onsite Support'' at Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), and Sandia National Laboratory (SNL). We fabricated and delivered over 1790 hohlraum mandrels and numerous other micromachined components to LLNL, LANL, and SNL. We produced more than 1380 glass and plastic target capsules over a wide range of sizes and designs (plus over 300 near target-quality capsules) for LLNL, LANL, SNL, and University of Rochester/Laboratory for Laser Energetic (UR/LLE). We also delivered various target foils and films for Naval Research Lab (NRL) and UWLLE in FY99. We fabricated a device to polish NIF-sized beryllium shells and prepared a laboratory for the safe operation of beryllium polishing activities. This report describes these target fabrication activities and the target fabrication and characterization development activities that made the deliveries possible. During FY99, the GA/Schafer portion of the GA/Schafer-UR/LLE-LANL team effort for design, procurement, installation, and testing of the OMEGA Cryogenic Target System (OCTS) that will field cryogenic targets on OMEGA was completed. All components of the OCTS were procured, fabricated, assembled, tested, and shipped to UR/LLE. Only minor documentation tasks remain to be done in FY00. The ICF program is anticipating experiments at the OMEGA laser and the National Ignition Facility (NIF) which will require targets containing cryogenic layered D2 or deuterium

  14. Technology.

    Science.gov (United States)

    Online-Offline, 1998

    1998-01-01

    Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

  15. National energy peak leveling program (NEPLP). Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-12-01

    This multisectioned three-Volume report is responsive to the requirements of Contract E (04-3)-1152 to provide a detailed methodology, to include management, technology, and socio-economic aspects, of a voluntary community program of computer-assisted peak load leveling and energy conservation in commercial community facilities. The demonstration project established proof-of-concept in reducing the kW-demand peak by the unofficial goal of 10%, with concurrent kWh savings. This section of volume III contains appendixes of information on load shedding determination, analysis, socio-economic study, contractual cross references, and definitions.

  16. National energy peak leveling program (NEPLP). Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1977-12-01

    This three-volume report is responsive to the requirements of Contract E (04-3)-1152 to provide a detailed methodology, to include management, technology, and socio-economic aspects, of a voluntary community program of computer-assisted peak load leveling and energy conservation in commercial community facilities. The demonstration project established proof-of-concept in reducing the kW-demand peak by the unofficial goal of 10%, with concurrent kWh savings. This section of the three volume report is a final report appendix with information on the financial management of load leveling, audit procedures, and building operating profiles.

  17. Technology

    Directory of Open Access Journals (Sweden)

    Xu Jing

    2016-01-01

    Full Text Available The traditional answer card reading method using OMR (Optical Mark Reader, most commonly, OMR special card special use, less versatile, high cost, aiming at the existing problems proposed a method based on pattern recognition of the answer card identification method. Using the method based on Line Segment Detector to detect the tilt of the image, the existence of tilt image rotation correction, and eventually achieve positioning and detection of answers to the answer sheet .Pattern recognition technology for automatic reading, high accuracy, detect faster

  18. [Effect of image fusion technology of radioactive particles implantation before and after the planning target and dosimetry].

    Science.gov (United States)

    Jiang, Y L; Yu, J P; Sun, H T; Guo, F X; Ji, Z; Fan, J H; Zhang, L J; Li, X; Wang, J J

    2017-08-01

    Objective: To compare the post-implant target volumes and dosimetric evaluation with pre-plan, the gross tumor volume(GTV) by CT image fusion-based and the manual delineation of target volume in CT guided radioactive seeds implantation. Methods: A total of 10 patients treated under CT-guidance (125)I seed implantation during March 2016 to April 2016 were analyzed in Peking University Third Hospital.All patients underwent pre-operative CT simulation, pre-operative planning, implantation seeds, CT scanning after seed implantation and dosimetric evaluation of GTV.In every patient, post-implant target volumes were delineated by both two methods, and were divided into two groups. Group 1: image fusion pre-implantation simulation and post-operative CT image, then the contours of GTV were automatically performed by brachytherapy treatment planning system; Group 2: the contouring of the GTV on post-operative CT image were performed manually by three senior radiation oncologists independently. The average of three data was sets. Statistical analyses were performed using SPSS software, version 3.2.0. The paired t -test was used to compare the target volumes and D(90) parameters in two modality. Results: In Group 1, average volume of GTV in post-operation group was 12-167(73±56) cm(3). D(90) was 101-153 (142±19)Gy. In Group 2, they were 14-186(80±58)cm(3) and 96-146(122±16) Gy respectively. In both target volumes and D(90), there was no statistical difference between pre-operation and post-operation in Group 1.The D(90) was slightly lower than that of pre-plan group, but there was no statistical difference ( P =0.142); in Group 2, between pre-operation and post-operation group, there was a significant statistical difference in the GTV ( P =0.002). The difference of D(90) was similarly ( P post-implant GTV through fusion pre-implantation simulation and post-operative CT scan images, the contours of GTV are automatically performed by brachytherapy treatment planning system

  19. Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells.

    Science.gov (United States)

    Tareen, Semih U; Kelley-Clarke, Brenna; Nicolai, Christopher J; Cassiano, Linda A; Nelson, Lisa T; Slough, Megan M; Vin, Chintan D; Odegard, Jared M; Sloan, Derek D; Van Hoeven, Neal; Allen, James M; Dubensky, Thomas W; Robbins, Scott H

    2014-03-01

    As sentinels of the immune system, dendritic cells (DCs) play an essential role in regulating cellular immune responses. One of the main challenges of developing DC-targeted therapies includes the delivery of antigen to DCs in order to promote the activation of antigen-specific effector CD8 T cells. With the goal of creating antigen-directed immunotherapeutics that can be safely administered directly to patients, Immune Design has developed a platform of novel integration-deficient lentiviral vectors that target and deliver antigen-encoding nucleic acids to human DCs. This platform, termed ID-VP02, utilizes a novel genetic variant of a Sindbis virus envelope glycoprotein with posttranslational carbohydrate modifications in combination with Vpx, a SIVmac viral accessory protein, to achieve efficient targeting and transduction of human DCs. In addition, ID-VP02 incorporates safety features in its design that include two redundant mechanisms to render ID-VP02 integration-deficient. Here, we describe the characteristics that allow ID-VP02 to specifically transduce human DCs, and the advances that ID-VP02 brings to conventional third-generation lentiviral vector design as well as demonstrate upstream production yields that will enable manufacturing feasibility studies to be conducted.

  20. A genome-wide analysis of lentivector integration sites using targeted sequence capture and next generation sequencing technology.

    Science.gov (United States)

    Ustek, Duran; Sirma, Sema; Gumus, Ergun; Arikan, Muzaffer; Cakiris, Aris; Abaci, Neslihan; Mathew, Jaicy; Emrence, Zeliha; Azakli, Hulya; Cosan, Fulya; Cakar, Atilla; Parlak, Mahmut; Kursun, Olcay

    2012-10-01

    One application of next-generation sequencing (NGS) is the targeted resequencing of interested genes which has not been used in viral integration site analysis of gene therapy applications. Here, we combined targeted sequence capture array and next generation sequencing to address the whole genome profiling of viral integration sites. Human 293T and K562 cells were transduced with a HIV-1 derived vector. A custom made DNA probe sets targeted pLVTHM vector used to capture lentiviral vector/human genome junctions. The captured DNA was sequenced using GS FLX platform. Seven thousand four hundred and eighty four human genome sequences flanking the long terminal repeats (LTR) of pLVTHM fragment sequences matched with an identity of at least 98% and minimum 50 bp criteria in both cells. In total, 203 unique integration sites were identified. The integrations in both cell lines were totally distant from the CpG islands and from the transcription start sites and preferentially located in introns. A comparison between the two cell lines showed that the lentiviral-transduced DNA does not have the same preferred regions in the two different cell lines. Copyright © 2012 Elsevier B.V. All rights reserved.

  1. Energy solutions for CO2 emission peak and subsequent decline

    DEFF Research Database (Denmark)

    Risø International Energy Conference 2009 took place 14 – 16 September 2009. The conference focused on: • Future global energy development options Scenario and policy issues • Measures to achieve CO2 emission peak in 2015 – 2020 and subsequent decline • Renewable energy supply technologies...... such as bioenergy, wind and solar • Centralized energy technologies such as clean coal technologies • Energy conversion, energy carriers and energy storage, including fuel cells and hydrogen technologies • Providing renewable energy for the transport sector • Systems aspects for the various regions throughout...... the world • End-use technologies, efficiency improvements in supply and end use • Energy savings The proceedings are prepared from papers presented at the conference and received with corrections, if any, until the final deadline on 3 August 2009....

  2. Smart households: Dispatch strategies and economic analysis of distributed energy storage for residential peak shaving

    International Nuclear Information System (INIS)

    Zheng, Menglian; Meinrenken, Christoph J.; Lackner, Klaus S.

    2015-01-01

    Highlights: • Cost-effectiveness of building-based storage for peak shaving has hitherto not been well understood. • Several existing storage technologies are shown to provide cost-effective peak shaving. • Setting grid demand targets rather than hard demand limits improves economics. • Accounting for seasonal demand variations in storage dispatch strategy improves economics further. • Total-energy-throughput approach is used to determine storage lifetimes. - Abstract: Meeting time-varying peak demand poses a key challenge to the U.S. electricity system. Building-based electricity storage – to enable demand response (DR) without curtailing actual appliance usage – offers potential benefits of lower electricity production cost, higher grid reliability, and more flexibility to integrate renewables. DR tariffs are currently available in the U.S. but building-based storage is still underutilized due to insufficiently understood cost-effectiveness and dispatch strategies. Whether DR schemes can yield a profit for building operators (i.e., reduction in electricity bill that exceeds levelized storage cost) and which particular storage technology yields the highest profit is yet to be answered. This study aims to evaluate the economics of providing peak shaving DR under a realistic tariff (Con Edison, New York), using a range of storage technologies (conventional and advanced batteries, flywheel, magnetic storage, pumped hydro, compressed air, and capacitors). An agent-based stochastic model is used to randomly generate appliance-level demand profiles for an average U.S. household. We first introduce a levelized storage cost model which is based on a total-energy-throughput lifetime. We then develop a storage dispatch strategy which optimizes the storage capacity and the demand limit on the grid. We find that (i) several storage technologies provide profitable DR; (ii) annual profit from such DR can range from 1% to 39% of the household’s non-DR electricity

  3. Passive radio frequency peak power multiplier

    Science.gov (United States)

    Farkas, Zoltan D.; Wilson, Perry B.

    1977-01-01

    Peak power multiplication of a radio frequency source by simultaneous charging of two high-Q resonant microwave cavities by applying the source output through a directional coupler to the cavities and then reversing the phase of the source power to the coupler, thereby permitting the power in the cavities to simultaneously discharge through the coupler to the load in combination with power from the source to apply a peak power to the load that is a multiplication of the source peak power.

  4. The geomorphic structure of the runoff peak

    Directory of Open Access Journals (Sweden)

    R. Rigon

    2011-06-01

    Full Text Available This paper develops a theoretical framework to investigate the core dependence of peak flows on the geomorphic properties of river basins. Based on the theory of transport by travel times, and simple hydrodynamic characterization of floods, this new framework invokes the linearity and invariance of the hydrologic response to provide analytical and semi-analytical expressions for peak flow, time to peak, and area contributing to the peak runoff. These results are obtained for the case of constant-intensity hyetograph using the Intensity-Duration-Frequency (IDF curves to estimate extreme flow values as a function of the rainfall return period. Results show that, with constant-intensity hyetographs, the time-to-peak is greater than rainfall duration and usually shorter than the basin concentration time. Moreover, the critical storm duration is shown to be independent of rainfall return period as well as the area contributing to the flow peak. The same results are found when the effects of hydrodynamic dispersion are accounted for. Further, it is shown that, when the effects of hydrodynamic dispersion are negligible, the basin area contributing to the peak discharge does not depend on the channel velocity, but is a geomorphic propriety of the basin. As an example this framework is applied to three watersheds. In particular, the runoff peak, the critical rainfall durations and the time to peak are calculated for all links within a network to assess how they increase with basin area.

  5. Revisiting nanoparticle technology for blood-brain barrier transport: Unfolding at the endothelial gate improves the fate of transferrin receptor-targeted liposomes.

    Science.gov (United States)

    Johnsen, Kasper Bendix; Moos, Torben

    2016-01-28

    An unmet need exists for therapeutic compounds to traverse the brain capillary endothelial cells that denote the blood-brain barrier (BBB) to deliver effective treatment to the diseased brain. The use of nanoparticle technology for targeted delivery to the brain implies that targeted liposomes encapsulating a drug of interest will undergo receptor-mediated uptake and transport through the BBB with a subsequent unfolding of the liposomal content inside the brain, hence revealing drug release to adjacent drug-demanding neurons. As transferrin receptors (TfRs) are present on brain capillary endothelial, but not on endothelial cells elsewhere in the body, the use of TfR-targeted liposomes - colloidal particulates with a phospholipid bilayer membrane - remains the most relevant strategy to obtain efficient drug delivery to the brain. However, many studies have failed to provide sufficient quantitative data to proof passage of the BBB and significant appearance of drugs inside the brain parenchyma. Here, we critically evaluate the current evidence on the use of TfR-targeted liposomes for brain drug delivery based on a thorough investigation of all available studies within this research field. We focus on issues with respect to experimental design and data analysis that may provide an explanation to conflicting reports, and we discuss possible explanations for the current lack of sufficient transcytosis across the BBB for implementation in the design of TfR-targeted liposomes. We finally provide a list of suggestions for strategies to obtain substantial uptake and transport of drug carriers at the BBB with a concomitant transport of therapeutics into the brain. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. RESULTS FROM RECENT SCIENCE AND TECHNOLOGY INVESTIGATIONS TARGETING CHROMIUM IN THE 100D AREA HANFORD SITE WASHINGTON USA

    Energy Technology Data Exchange (ETDEWEB)

    PETERSEN SW; THOMPSON KM; TONKIN MJ

    2009-12-03

    Sodium dichromate was used in Hanford's 100D Area during the reactor operations period of 1950 to 1964 to retard corrosion in the reactor cooling systems. Some of the sodium dichromate was released to the environment by spills and/or leaks from pipelines used to deliver the chemical to water treatment plants in the area. As a result, hexavalent chromium [Cr(VI)] has migrated through the vadose zone to the groundwater and contaminated nearly 1 km{sup 2} of groundwater to above the drinking water standard of 48 {micro}g/L. Three technology tests have recently been completed in this area to characterize the source area of the plumes and evaluate alternative methods to remove Cr(VI) from groundwater. These are (1) refine the source area of the southern plume; (2) test electrocoagulation as an alternative groundwater treatment technology; and (3) test the ability to repair a permeable reactive barrier by injecting micron or nanometer-size zero-valent iron (ZVI). The projects were funded by the US Department of Energy as part of a program to interject new technologies and accelerate active cleanup. Groundwater monitoring over the past 10 years has shown that Cr(VI) concentrations in the southern plume have not significantly diminished, strongly indicating a continuing source. Eleven groundwater wells were installed in 2007 and 2008 near a suspected source area and monitored for Cr(VI) and groundwater levels. Interpretation of these data has led to refinement of the source area location to an area of less than 1 hectare (ha, 2.5 acres). Vadose zone soil samples collected during drilling did not discover significant concentrations of Cr(VI), indicating the source is localized, with a narrow wetted path from the surface to the water table. Electrocoagulation was evaluated through a pilot-scale treatability test. Over 8 million liters of groundwater were treated to Cr(VI) concentrations of {le}20 {micro}g/L. The test determined that this technology has the potential to

  7. Targeted technology applications for infield reserve growth: A synopsis of the Secondary Natural Gas Recovery project, Gulf Coast Basin. Topical report, September 1988--April 1993

    Energy Technology Data Exchange (ETDEWEB)

    Levey, R.A.; Finley, R.J.; Hardage, B.A.

    1994-06-01

    The Secondary Natural Gas Recovery (SGR): Targeted Technology Applications for Infield Reserve Growth is a joint venture research project sponsored by the Gas Research Institute (GRI), the US Department of Energy (DOE), the State of Texas through the Bureau of Economic Geology at The University of Texas at Austin, with the cofunding and cooperation of the natural gas industry. The SGR project is a field-based program using an integrated multidisciplinary approach that integrates geology, geophysics, engineering, and petrophysics. A major objective of this research project is to develop, test, and verify those technologies and methodologies that have near- to mid-term potential for maximizing recovery of gas from conventional reservoirs in known fields. Natural gas reservoirs in the Gulf Coast Basin are targeted as data-rich, field-based models for evaluating infield development. The SGR research program focuses on sandstone-dominated reservoirs in fluvial-deltaic plays within the onshore Gulf Coast Basin of Texas. The primary project research objectives are: To establish how depositional and diagenetic heterogeneities cause, even in reservoirs of conventional permeability, reservoir compartmentalization and hence incomplete recovery of natural gas. To document examples of reserve growth occurrence and potential from fluvial and deltaic sandstones of the Texas Gulf Coast Basin as a natural laboratory for developing concepts and testing applications. To demonstrate how the integration of geology, reservoir engineering, geophysics, and well log analysis/petrophysics leads to strategic recompletion and well placement opportunities for reserve growth in mature fields.

  8. The effect of mood state on visual search times for detecting a target in noise: An application of smartphone technology.

    Science.gov (United States)

    Maekawa, Toru; Anderson, Stephen J; de Brecht, Matthew; Yamagishi, Noriko

    2018-01-01

    The study of visual perception has largely been completed without regard to the influence that an individual's emotional status may have on their performance in visual tasks. However, there is a growing body of evidence to suggest that mood may affect not only creative abilities and interpersonal skills but also the capacity to perform low-level cognitive tasks. Here, we sought to determine whether rudimentary visual search processes are similarly affected by emotion. Specifically, we examined whether an individual's perceived happiness level affects their ability to detect a target in noise. To do so, we employed pop-out and serial visual search paradigms, implemented using a novel smartphone application that allowed search times and self-rated levels of happiness to be recorded throughout each twenty-four-hour period for two weeks. This experience sampling protocol circumvented the need to alter mood artificially with laboratory-based induction methods. Using our smartphone application, we were able to replicate the classic visual search findings, whereby pop-out search times remained largely unaffected by the number of distractors whereas serial search times increased with increasing number of distractors. While pop-out search times were unaffected by happiness level, serial search times with the maximum numbers of distractors (n = 30) were significantly faster for high happiness levels than low happiness levels (p = 0.02). Our results demonstrate the utility of smartphone applications in assessing ecologically valid measures of human visual performance. We discuss the significance of our findings for the assessment of basic visual functions using search time measures, and for our ability to search effectively for targets in real world settings.

  9. Peak Shaving Considering Streamflow Uncertainties | Iwuagwu ...

    African Journals Online (AJOL)

    The main thrust of this paper is peak shaving with a Stochastic hydro model. In peak sharing, the amount of hydro energy scheduled may be a minimum but it serves to replace less efficient thermal units. The sample system is die Kainji hydro plant and the thermal units of the National Electric Power Authority. The random ...

  10. Advanced scale conditioning agent and consolidated deposit extraction planning, application experience, and results at Comanche Peak Unit 2 and industrial super critical water oxidation waste reduction

    International Nuclear Information System (INIS)

    Forney, M.; Ramaley, D.; Bryant, W.

    2015-01-01

    Advance Scale Conditioning Agent (ASCA) technology has been applied more than forty times worldwide since its inception in 2000. This technology has continually grown in popularity since its development due to the combination of several process benefits and minimal outage impacts. Comanche Peak Unit 2 applied a Top of Tubesheet (TTS) ASCA in 2014 for partial dissolution and softening of consolidated TTS collars. In addition to the ASCA application, a Consolidated Deposit Extraction (CODE) step was applied to the TTS. CODE is a chemical treatment technology that effectively targets and dissolves 'binding species' such as those containing aluminum and silicon from steam generator deposits. Since magnetite dissolution technologies are not wholly effective in removing consolidated TTS 'collars' CODE technology was developed to address this need in the industry. This paper will discuss both the Westinghouse and utility perspective on TTS ASCA/CODE application planning, site execution, and process results. (author)

  11. Advanced scale conditioning agent and consolidated deposit extraction planning, application experience, and results at Comanche Peak Unit 2 and industrial super critical water oxidation waste reduction

    Energy Technology Data Exchange (ETDEWEB)

    Forney, M.; Ramaley, D. [Westinghouse Electric Company, Cranberry Township, PA (United States); Bryant, W. [Luminant Energy, Comanche Peak Nuclear Power Plant, Dallas, TX (United States)

    2015-07-01

    Advance Scale Conditioning Agent (ASCA) technology has been applied more than forty times worldwide since its inception in 2000. This technology has continually grown in popularity since its development due to the combination of several process benefits and minimal outage impacts. Comanche Peak Unit 2 applied a Top of Tubesheet (TTS) ASCA in 2014 for partial dissolution and softening of consolidated TTS collars. In addition to the ASCA application, a Consolidated Deposit Extraction (CODE) step was applied to the TTS. CODE is a chemical treatment technology that effectively targets and dissolves 'binding species' such as those containing aluminum and silicon from steam generator deposits. Since magnetite dissolution technologies are not wholly effective in removing consolidated TTS 'collars' CODE technology was developed to address this need in the industry. This paper will discuss both the Westinghouse and utility perspective on TTS ASCA/CODE application planning, site execution, and process results. (author)

  12. Quantitative Detection of Listeria monocytogenes and Listeria innocua by Real-Time PCR: Assessment of hly, iap, and lin02483 Targets and AmpliFluor Technology

    Science.gov (United States)

    Rodríguez-Lázaro, David; Hernández, Marta; Scortti, Mariela; Esteve, Teresa; Vázquez-Boland, José A.; Pla, Maria

    2004-01-01

    We developed and assessed real-time PCR (RTi-PCR) assays for the detection and quantification of the food-borne pathogen Listeria monocytogenes and the closely related nonpathogenic species L. innocua. The target genes were hly and iap for L. monocytogenes and lin02483 for L. innocua. The assays were 100% specific, as determined with 100 Listeria strains and 45 non-Listeria strains, and highly sensitive, with detection limits of one target molecule in 11 to 56% of the reactions with purified DNA and 3 CFU in 56 to 89% of the reactions with bacterial suspensions. Quantification was possible over a 5-log dynamic range, with a limit of 15 target molecules and R2 values of >0.996. There was an excellent correspondence between the predicted and the actual numbers of CFU in the samples (deviations of <23%). The hly-based assay accurately quantified L. monocytogenes in all of the samples tested. The iap-based assay, in contrast, was unsuitable for quantification purposes, underestimating the bacterial counts by 3 to 4 log units in a significant proportion of the samples due to serovar-related target sequence variability. The combination of the two assays enabled us to classify L. monocytogenes isolates into one of the two major phylogenetic divisions of the species, I and II. We also assessed the new AmpliFluor technology for the quantitative detection of L. monocytogenes by RTi-PCR. The performance of this system was similar to that of the TaqMan system, although the former system was slightly less sensitive (detection limit of 15 molecules in 45% of the reactions) and had a higher quantification limit (60 molecules). PMID:15006755

  13. Satisfaction Survey on Information Technology-Based Glucose Monitoring System Targeting Diabetes Mellitus in Private Local Clinics in Korea

    Directory of Open Access Journals (Sweden)

    Hun-Sung Kim

    2017-06-01

    Full Text Available BackgroundPrivate local clinics in Korea have little experience with information technology (IT-based glucose monitoring (ITGM. Our aim is to examine user satisfaction and the possibility of using ITGM service practically.MethodsPatients sent their blood glucose levels to physicians in local clinics. The physicians reviewed the blood glucose values online and provided personal consultations through text messaging or phone calls. Thereafter, a satisfaction survey on the ITGM service, the modified Morisky scale, and patient assessment of chronic illness care were administered.ResultsOne hundred and seventy patients from seven private local clinics used the ITGM. Overall satisfaction, including that about the ITGM service, the device, and its usefulness, was rated higher than “mostly satisfied” (score 4.2±0.8 out of 5.0 and even higher among the elderly. Satisfaction was positively associated with age, especially in those older than 60 years. The main reason for intent for future use of the service was the time/place flexibility. Highly motivated patients tended to answer positively regarding information satisfaction (P=0.0377.ConclusionOur study is the first to investigate ITGM satisfaction in private local clinics. The feasibility of users utilizing ITGM should be clarified, and future clinical research on the service's clinical effects and cost-benefit analysis is needed.

  14. Automated Peak Picking and Peak Integration in Macromolecular NMR Spectra Using AUTOPSY

    Science.gov (United States)

    Koradi, Reto; Billeter, Martin; Engeli, Max; Güntert, Peter; Wüthrich, Kurt

    1998-12-01

    A new approach for automated peak picking of multidimensional protein NMR spectra with strong overlap is introduced, which makes use of the program AUTOPSY (automatedpeak picking for NMRspectroscopy). The main elements of this program are a novel function for local noise level calculation, the use of symmetry considerations, and the use of lineshapes extracted from well-separated peaks for resolving groups of strongly overlapping peaks. The algorithm generates peak lists with precise chemical shift and integral intensities, and a reliability measure for the recognition of each peak. The results of automated peak picking of NOESY spectra with AUTOPSY were tested in combination with the combined automated NOESY cross peak assignment and structure calculation routine NOAH implemented in the program DYANA. The quality of the resulting structures was found to be comparable with those from corresponding data obtained with manual peak picking.

  15. Bayesian Peak Picking for NMR Spectra

    KAUST Repository

    Cheng, Yichen

    2014-02-01

    Protein structure determination is a very important topic in structural genomics, which helps people to understand varieties of biological functions such as protein-protein interactions, protein–DNA interactions and so on. Nowadays, nuclear magnetic resonance (NMR) has often been used to determine the three-dimensional structures of protein in vivo. This study aims to automate the peak picking step, the most important and tricky step in NMR structure determination. We propose to model the NMR spectrum by a mixture of bivariate Gaussian densities and use the stochastic approximation Monte Carlo algorithm as the computational tool to solve the problem. Under the Bayesian framework, the peak picking problem is casted as a variable selection problem. The proposed method can automatically distinguish true peaks from false ones without preprocessing the data. To the best of our knowledge, this is the first effort in the literature that tackles the peak picking problem for NMR spectrum data using Bayesian method.

  16. Global Earthquake Hazard Distribution - Peak Ground Acceleration

    Data.gov (United States)

    National Aeronautics and Space Administration — Global Earthquake Hazard Distribution-Peak Ground Acceleration is a 2.5 by 2.5 minute grid of global earthquake hazards developed using Global Seismic Hazard Program...

  17. Helping System Engineers Bridge the Peaks

    Science.gov (United States)

    Rungta, Neha; Tkachuk, Oksana; Person, Suzette; Biatek, Jason; Whalen, Michael W.; Castle, Joseph; Castle, JosephGundy-Burlet, Karen

    2014-01-01

    In our experience at NASA, system engineers generally follow the Twin Peaks approach when developing safety-critical systems. However, iterations between the peaks require considerable manual, and in some cases duplicate, effort. A significant part of the manual effort stems from the fact that requirements are written in English natural language rather than a formal notation. In this work, we propose an approach that enables system engineers to leverage formal requirements and automated test generation to streamline iterations, effectively "bridging the peaks". The key to the approach is a formal language notation that a) system engineers are comfortable with, b) is supported by a family of automated V&V tools, and c) is semantically rich enough to describe the requirements of interest. We believe the combination of formalizing requirements and providing tool support to automate the iterations will lead to a more efficient Twin Peaks implementation at NASA.

  18. Bayesian Peak Picking for NMR Spectra

    Directory of Open Access Journals (Sweden)

    Yichen Cheng

    2014-02-01

    Full Text Available Protein structure determination is a very important topic in structural genomics, which helps people to understand varieties of biological functions such as protein-protein interactions, protein–DNA interactions and so on. Nowadays, nuclear magnetic resonance (NMR has often been used to determine the three-dimensional structures of protein in vivo. This study aims to automate the peak picking step, the most important and tricky step in NMR structure determination. We propose to model the NMR spectrum by a mixture of bivariate Gaussian densities and use the stochastic approximation Monte Carlo algorithm as the computational tool to solve the problem. Under the Bayesian framework, the peak picking problem is casted as a variable selection problem. The proposed method can automatically distinguish true peaks from false ones without preprocessing the data. To the best of our knowledge, this is the first effort in the literature that tackles the peak picking problem for NMR spectrum data using Bayesian method.

  19. How to use your peak flow meter

    Science.gov (United States)

    ... attack . This can tell you how bad your asthma attack is and if your medicine is working. Any ... Make peak flow a habit! Signs of an asthma attack Stay away from asthma triggers Review Date 2/ ...

  20. Global Earthquake Hazard Distribution - Peak Ground Acceleration

    Data.gov (United States)

    National Aeronautics and Space Administration — Global Earthquake Hazard Distribution-peak ground acceleration is a 2.5 minute grid of global earthquake hazards developed using Global Seismic Hazard Program...

  1. Peak-Seeking Control for Trim Optimization

    Data.gov (United States)

    National Aeronautics and Space Administration — Innovators have developed a peak-seeking algorithm that can reduce drag and improve performance and fuel efficiency by optimizing aircraft trim in real time. The...

  2. Improved peak shape fitting in alpha spectra

    OpenAIRE

    POMME Stefaan; CARO MARROYO BELEN

    2014-01-01

    Peak overlap is a recurrent issue ina lpha-particle spectrometry, not only in routine analyses but also in the high-resolution spectra from which reference values for alpha emission probabilities are derived. In this work, improved peak shape formulae are presented for the deconvolution of alpha-particle spectra. They have been implemented as fit functions in a spreadsheet application and optimum fit parameters were searched with built-in optimisation routines. Deconvolution results are shown...

  3. Peak quantification in surface-enhanced laser desorption/ionization by using mixture models

    NARCIS (Netherlands)

    Dijkstra, Martijn; Roelofsen, Han; Vonk, Roel J.; Jansen, Ritsert C.

    2006-01-01

    Surface-enhanced laser desorption/ionization (SELDI) time of flight (TOF) is a mass spectrometry technology for measuring the composition of a sampled protein mixture. A mass spectrum contains peaks corresponding to proteins in the sample. The peak areas are proportional to the measured

  4. Storage Operation for Peak Shaving of Distributed PV and Wind Generation

    NARCIS (Netherlands)

    Nykamp, Stefan; Molderink, Albert; Hurink, Johann L.; Smit, Gerardus Johannes Maria

    2013-01-01

    The integration of fluctuating power generation based on renewable energy systems (RES-E) in distribution grids require grid reinforcement resulting from high feed-in peaks. Introducing storage assets can decrease these peaks. For this, storage technologies need to be chosen and dimensioned

  5. Instream flow needs below peaking hydroelectric projects

    International Nuclear Information System (INIS)

    Milhous, R.T.

    1991-01-01

    This paper reports on a method developed to assist in the determination of instream flow needs below hydroelectric projects operated in a peaking mode. Peaking hydroelectric projects significantly change streamflow over a short period of time; consequently, any instream flow methodology must consider the dual flows associated with peaking projects. The dual flows are the lowest flow and the maximum generation flow of a peaking cycle. The methodology is based on elements of the Physical Habitat Simulation System of the U.S. Fish and Wildlife Service and uses habitat, rather than fish numbers or biomas, as at basic response variable. All aquatic animals are subject to the rapid changes in streamflow which cause rapid swings in habitat quality. Some aquatic organisms are relatively fixed in location in the stream while others can move when flows change. The habitat available from a project operated in peaking mode is considered to be the minimum habitat occurring during a cycle of habitat change. The methodology takes in to consideration that some aquatic animals can move and others cannot move during a peaking cycle

  6. Considerations for human exposure standards for fast-rise-time high-peak-power electromagnetic pulses.

    Science.gov (United States)

    Merritt, J H; Kiel, J L; Hurt, W D

    1995-06-01

    Development of new emitter systems capable of producing high-peak-power electromagnetic pulses with very fast rise times and narrow pulse widths is continuing. Such directed energy weapons systems will be used in the future to defeat electronically vulnerable targets. Human exposures to these pulses can be expected during testing and operations. Development of these technologies for radar and communications purposes has the potential for wider environmental exposure, as well. Current IEEE C95.1-1991 human exposure guidelines do not specifically address these types of pulses, though limits are stated for pulsed emissions. The process for developing standards includes an evaluation of the relevant bioeffects data base. A recommendation has been made that human exposure to ultrashort electromagnetic pulses that engender electromagnetic transients, called precursor waves, should be avoided. Studies that purport to show the potential for tissue damage induced by such pulses were described. The studies cited in support of the recommendation were not relevant to the issues of tissue damage by propagated pulses. A number of investigations are cited in this review that directly address the biological effects of electromagnetic pulses. These studies have not shown evidence of tissue damage as a result of exposure to high-peak-power pulsed microwaves. It is our opinion that the current guidelines are sufficiently protective for human exposure to these pulses.

  7. Predicting Peak Flows following Forest Fires

    Science.gov (United States)

    Elliot, William J.; Miller, Mary Ellen; Dobre, Mariana

    2016-04-01

    Following forest fires, peak flows in perennial and ephemeral streams often increase by a factor of 10 or more. This increase in peak flow rate may overwhelm existing downstream structures, such as road culverts, causing serious damage to road fills at stream crossings. In order to predict peak flow rates following wildfires, we have applied two different tools. One is based on the U.S.D.A Natural Resource Conservation Service Curve Number Method (CN), and the other is by applying the Water Erosion Prediction Project (WEPP) to the watershed. In our presentation, we will describe the science behind the two methods, and present the main variables for each model. We will then provide an example of a comparison of the two methods to a fire-prone watershed upstream of the City of Flagstaff, Arizona, USA, where a fire spread model was applied for current fuel loads, and for likely fuel loads following a fuel reduction treatment. When applying the curve number method, determining the time to peak flow can be problematic for low severity fires because the runoff flow paths are both surface and through shallow lateral flow. The WEPP watershed version incorporates shallow lateral flow into stream channels. However, the version of the WEPP model that was used for this study did not have channel routing capabilities, but rather relied on regression relationships to estimate peak flows from individual hillslope polygon peak runoff rates. We found that the two methods gave similar results if applied correctly, with the WEPP predictions somewhat greater than the CN predictions. Later releases of the WEPP model have incorporated alternative methods for routing peak flows that need to be evaluated.

  8. New weather depiction technology for night vision goggle (NVG) training: 3D virtual/augmented reality scene-weather-atmosphere-target simulation

    Science.gov (United States)

    Folaron, Michelle; Deacutis, Martin; Hegarty, Jennifer; Vollmerhausen, Richard; Schroeder, John; Colby, Frank P.

    2007-04-01

    US Navy and Marine Corps pilots receive Night Vision Goggle (NVG) training as part of their overall training to maintain the superiority of our forces. This training must incorporate realistic targets; backgrounds; and representative atmospheric and weather effects they may encounter under operational conditions. An approach for pilot NVG training is to use the Night Imaging and Threat Evaluation Laboratory (NITE Lab) concept. The NITE Labs utilize a 10' by 10' static terrain model equipped with both natural and cultural lighting that are used to demonstrate various illumination conditions, and visual phenomena which might be experienced when utilizing night vision goggles. With this technology, the military can safely, systematically, and reliably expose pilots to the large number of potentially dangerous environmental conditions that will be experienced in their NVG training flights. A previous SPIE presentation described our work for NAVAIR to add realistic atmospheric and weather effects to the NVG NITE Lab training facility using the NVG - WDT(Weather Depiction Technology) system (Colby, et al.). NVG -WDT consist of a high end multiprocessor server with weather simulation software, and several fixed and goggle mounted Heads Up Displays (HUDs). Atmospheric and weather effects are simulated using state-of-the-art computer codes such as the WRF (Weather Research μ Forecasting) model; and the US Air Force Research Laboratory MODTRAN radiative transport model. Imagery for a variety of natural and man-made obscurations (e.g. rain, clouds, snow, dust, smoke, chemical releases) are being calculated and injected into the scene observed through the NVG via the fixed and goggle mounted HUDs. This paper expands on the work described in the previous presentation and will describe the 3D Virtual/Augmented Reality Scene - Weather - Atmosphere - Target Simulation part of the NVG - WDT. The 3D virtual reality software is a complete simulation system to generate realistic

  9. Electron beam fusion targets

    International Nuclear Information System (INIS)

    Clauser, M.J.; Sweeney, M.A.

    1975-01-01

    R The behavior of the DT filled gold shells when irradiated by a variety of pulse shapes was studied. In these pulses the power (and beam current) was varied, but the voltage was kept constant at 1 MeV. In general the performance of the target, for a given peak power, was not significantly affected by the pulse shape. Pulses with rise times of up to half the implosion time do not significantly degrade the target performance. The use of the ''optimal pulse'' of laser fusion with a fixed peak power does not appear to improve the performance of these targets. The main function of the ''optimal pulse'' is to produce a large rho r of the target during the thermonuclear burn. In e-beam targets a total rho r of 5--10 g/cm 2 can be obtained without pulse shaping; the problem here is one of achieving high enough temperatures to ignite the DT. (U.S.)

  10. The Combinational Use of CRISPR/Cas9 and Targeted Toxin Technology Enables Efficient Isolation of Bi-Allelic Knockout Non-Human Mammalian Clones

    Directory of Open Access Journals (Sweden)

    Satoshi Watanabe

    2018-04-01

    targeted to be knocked out. Our results indicate that a combination of the CRISPR/Cas9 system and targeted toxin technology using IB4SAP allows efficient enrichment of genome-edited clones, particularly bi-allelic KO clones.

  11. Implementing peak load reduction algorithms for household electrical appliances

    International Nuclear Information System (INIS)

    Dlamini, Ndumiso G.; Cromieres, Fabien

    2012-01-01

    Considering household appliance automation for reduction of household peak power demand, this study explored aspects of the interaction between household automation technology and human behaviour. Given a programmable household appliance switching system, and user-reported appliance use times, we simulated the load reduction effectiveness of three types of algorithms, which were applied at both the single household level and across all 30 households. All three algorithms effected significant load reductions, while the least-to-highest potential user inconvenience ranking was: coordinating the timing of frequent intermittent loads (algorithm 2); moving period-of-day time-flexible loads to off-peak times (algorithm 1); and applying short-term time delays to avoid high peaks (algorithm 3) (least accommodating). Peak reduction was facilitated by load interruptibility, time of use flexibility and the willingness of users to forgo impulsive appliance use. We conclude that a general factor determining the ability to shift the load due to a particular appliance is the time-buffering between the service delivered and the power demand of an appliance. Time-buffering can be ‘technologically inherent’, due to human habits, or realised by managing user expectations. There are implications for the design of appliances and home automation systems. - Highlights: ► We explored the interaction between appliance automation and human behaviour. ► There is potential for considerable load shifting of household appliances. ► Load shifting for load reduction is eased with increased time buffering. ► Design, human habits and user expectations all influence time buffering. ► Certain automation and appliance design features can facilitate load shifting.

  12. Analysis of fuel end-temperature peaking

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Z.; Jiang, Q.; Lai, L.; Shams, M. [CANDU Energy Inc., Fuel Engineering Dept., Mississauga, Ontario (Canada)

    2013-07-01

    During normal operation and refuelling of CANDU® fuel, fuel temperatures near bundle ends will increase due to a phenomenon called end flux peaking. Similar phenomenon would also be expected to occur during a postulated large break LOCA event. The end flux peaking in a CANDU fuel element is due to the fact that neutron flux is higher near a bundle end, in contact with a neighbouring bundle or close to heavy water coolant, than in the bundle mid-plane, because of less absorption of thermal neutrons by Zircaloy or heavy water than by the UO{sub 2} material. This paper describes Candu Energy experience in analysing behaviour of bundle due to end flux peaking using fuel codes FEAT, ELESTRES and ELOCA. (author)

  13. Generation Mix Study Focusing on Nuclear Power by Practical Peak Forecast

    International Nuclear Information System (INIS)

    Shin, Jung Ho; Roh, Myung Sub

    2013-01-01

    The excessive underestimation can lead to a range of problem; expansion of LNG plant requiring short construction period, the following increase of electricity price, low reserve margin and inefficient configuration of power source. With regard to nuclear power, the share of the stable and economic base load plant, nuclear power, can reduce under the optimum level. Amongst varied factors which contribute to the underestimate, immoderate target for demand side management (DSM) including double deduction of the constraint amount by DSM from peak demand forecast is one of the causes. The hypothesis in this study is that the better optimum generation mix including the adequate share of nuclear power can be obtained under the condition of the peak demand forecast without deduction of DSM target because this forecast is closer to the actual peak demand. In this study, the hypothesis is verified with comparison between peak demand forecast before (or after) DSM target application and the actual peak demand in the 3 rd through 5 th BPE from 2006 to 2010. Furthermore, this research compares and analyzes several generation mix in 2027 focusing on the nuclear power by a few conditions using the WASP-IV program on the basis of the 6 th BPE in 2013. According to the comparative analysis on the peak demand forecast and actual peak demand from 2006 to 2010, the peak demand forecasts without the deduction of the DSM target is closer to the actual peak demand than the peak demand forecasts considering the DSM target in the 3 th , 4 th , 5 th entirely. In addition, the generation mix until 2027 is examined by the WASP-IV. As a result of the program run, when considering the peak demand forecast without DSM reflection, since the base load plants including nuclear power take up adequate proportion, stable and economic supply of electricity can be achieved. On the contrary, in case of planning based on the peak demand forecast with DSM reflected and then compensating the shortage by

  14. Effective climate-energy solutions, escape routes and peak oil

    International Nuclear Information System (INIS)

    Bergh, Jeroen C.J.M. van den

    2012-01-01

    Many well-intended climate-energy strategies are ineffective in the absence of serious environmental regulation. This holds, among others, for direct support of clean energy, voluntary energy conservation, technical standards on a limited set of products, unilateral stringent carbon pricing, and awaiting peak oil as a climate strategy. All of these suffer from “escape routes” that indirectly increase CO 2 emissions and thus make the original strategy ineffective. On the other hand, environmental regulation alone may lead to a myopia-bias, stimulating early dominance of cost-effective technologies and a focus on incremental innovations associated with such technologies rather than on radical innovations. Although adopting a partial viewpoint keeps the analysis simple, we urgently need a more inclusive systems perspective on climate solutions. This will allow the formulation of an effective climate policy package that addresses the various escape routes. - Highlights: ► Many well-intended climate-energy strategies are ineffective because of escape routes. ► In this context the relationship between peak oil and climate policy receives attention. ► Environmental regulation alone creates myopia-bias, the resolution of which requires technology-specific policies. ► To formulate an effective climate policy package an inclusive systems perspective is needed.

  15. Science + Technology = Intelligence on Target

    Science.gov (United States)

    2008-03-01

    in the postal sys- tem right here in Washington. Th at was about a billion dollars. And we don’t have to imagine a scenario of how our milk supply...We know about it because it was the cause of mad cow disease or the Creutzfeldt- Jakob disease in humans. And the images show the brain of a deer...swimming. It wasn’t hard to convince the women that that’s what made your kids sick. Now let me talk a little bit about the global climate situation

  16. Norfolk Schools Talked to Astronaut Tim Peake

    Science.gov (United States)

    Grant, Stephanie

    2016-01-01

    Tim Peake's mission to the International Space Station captured the imagination of the UK and this article describes a live radio link with him, to help him to reach out to pupils across the country and inspire them in STEM subjects. It describes the project, from bidding for the opportunity to host it, to the planning and realisation of the…

  17. Generalized Eck peak in inhomogeneous Josephson junctions

    Science.gov (United States)

    Fistul, Mikhail V.; Giuliani, Gabriele F.

    1997-02-01

    In inhomogeneous Josephson junctions the Eck peak characterizing the current-voltage characteristics is predicted to be replaced by a rather different yet prominent feature whose location and shape strongly depend on the strength of the applied magnetic field and the spatial correlations of the associated distorted Abrikosov flux lattice.

  18. Prediction of peak overlap in NMR spectra

    International Nuclear Information System (INIS)

    Hefke, Frederik; Schmucki, Roland; Güntert, Peter

    2013-01-01

    Peak overlap is one of the major factors complicating the analysis of biomolecular NMR spectra. We present a general method for predicting the extent of peak overlap in multidimensional NMR spectra and its validation using both, experimental data sets and Monte Carlo simulation. The method is based on knowledge of the magnetization transfer pathways of the NMR experiments and chemical shift statistics from the Biological Magnetic Resonance Data Bank. Assuming a normal distribution with characteristic mean value and standard deviation for the chemical shift of each observable atom, an analytic expression was derived for the expected overlap probability of the cross peaks. The analytical approach was verified to agree with the average peak overlap in a large number of individual peak lists simulated using the same chemical shift statistics. The method was applied to eight proteins, including an intrinsically disordered one, for which the prediction results could be compared with the actual overlap based on the experimentally measured chemical shifts. The extent of overlap predicted using only statistical chemical shift information was in good agreement with the overlap that was observed when the measured shifts were used in the virtual spectrum, except for the intrinsically disordered protein. Since the spectral complexity of a protein NMR spectrum is a crucial factor for protein structure determination, analytical overlap prediction can be used to identify potentially difficult proteins before conducting NMR experiments. Overlap predictions can be tailored to particular classes of proteins by preparing statistics from corresponding protein databases. The method is also suitable for optimizing recording parameters and labeling schemes for NMR experiments and improving the reliability of automated spectra analysis and protein structure determination.

  19. Martial arts striking hand peak acceleration, accuracy and consistency.

    Science.gov (United States)

    Neto, Osmar Pinto; Marzullo, Ana Carolina De Miranda; Bolander, Richard P; Bir, Cynthia A

    2013-01-01

    The goal of this paper was to investigate the possible trade-off between peak hand acceleration and accuracy and consistency of hand strikes performed by martial artists of different training experiences. Ten male martial artists with training experience ranging from one to nine years volunteered to participate in the experiment. Each participant performed 12 maximum effort goal-directed strikes. Hand acceleration during the strikes was obtained using a tri-axial accelerometer block. A pressure sensor matrix was used to determine the accuracy and consistency of the strikes. Accuracy was estimated by the radial distance between the centroid of each subject's 12 strikes and the target, whereas consistency was estimated by the square root of the 12 strikes mean squared distance from their centroid. We found that training experience was significantly correlated to hand peak acceleration prior to impact (r(2)=0.456, p =0.032) and accuracy (r(2)=0. 621, p=0.012). These correlations suggest that more experienced participants exhibited higher hand peak accelerations and at the same time were more accurate. Training experience, however, was not correlated to consistency (r(2)=0.085, p=0.413). Overall, our results suggest that martial arts training may lead practitioners to achieve higher striking hand accelerations with better accuracy and no change in striking consistency.

  20. Mineral Resources: Reserves, Peak Production and the Future

    Directory of Open Access Journals (Sweden)

    Lawrence D. Meinert

    2016-02-01

    Full Text Available The adequacy of mineral resources in light of population growth and rising standards of living has been a concern since the time of Malthus (1798, but many studies erroneously forecast impending peak production or exhaustion because they confuse reserves with “all there is”. Reserves are formally defined as a subset of resources, and even current and potential resources are only a small subset of “all there is”. Peak production or exhaustion cannot be modeled accurately from reserves. Using copper as an example, identified resources are twice as large as the amount projected to be needed through 2050. Estimates of yet-to-be discovered copper resources are up to 40-times more than currently-identified resources, amounts that could last for many centuries. Thus, forecasts of imminent peak production due to resource exhaustion in the next 20–30 years are not valid. Short-term supply problems may arise, however, and supply-chain disruptions are possible at any time due to natural disasters (earthquakes, tsunamis, hurricanes or political complications. Needed to resolve these problems are education and exploration technology development, access to prospective terrain, better recycling and better accounting of externalities associated with production (pollution, loss of ecosystem services and water and energy use.

  1. Mineral resources: Reserves, peak production and the future

    Science.gov (United States)

    Meinert, Lawrence D.; Robinson, Gilpin; Nassar, Nedal

    2016-01-01

    The adequacy of mineral resources in light of population growth and rising standards of living has been a concern since the time of Malthus (1798), but many studies erroneously forecast impending peak production or exhaustion because they confuse reserves with “all there is”. Reserves are formally defined as a subset of resources, and even current and potential resources are only a small subset of “all there is”. Peak production or exhaustion cannot be modeled accurately from reserves. Using copper as an example, identified resources are twice as large as the amount projected to be needed through 2050. Estimates of yet-to-be discovered copper resources are up to 40-times more than currently-identified resources, amounts that could last for many centuries. Thus, forecasts of imminent peak production due to resource exhaustion in the next 20–30 years are not valid. Short-term supply problems may arise, however, and supply-chain disruptions are possible at any time due to natural disasters (earthquakes, tsunamis, hurricanes) or political complications. Needed to resolve these problems are education and exploration technology development, access to prospective terrain, better recycling and better accounting of externalities associated with production (pollution, loss of ecosystem services and water and energy use).

  2. Mean and peak wind load reduction on heliostats

    Energy Technology Data Exchange (ETDEWEB)

    Peterka, J.A.; Tan, L.; Bienkiewcz, B.; Cermak, J.E.

    1987-09-01

    This report presents the results of wind-tunnel tests supported through the Solar Energy Research Institute (SERI) by the Office of Solar Thermal Technology of the US Department of Energy as part of the SERI research effort on innovative concentrators. As gravity loads on drive mechanisms are reduced through stretched-membrane technology, the wind-load contribution of the required drive capacity increases in percentage. Reduction of wind loads can provide economy in support structure and heliostat drive. Wind-tunnel tests have been directed at finding methods to reduce wind loads on heliostats. The tests investigated both mean and peak forces, and moments. A significant increase in ability to predict heliostat wind loads and their reduction within a heliostat field was achieved. In addition, a preliminary review of wind loads on parabolic dish collectors was conducted, resulting in a recommended research program for these type collectors. 42 refs., 38 figs., 1 tab.

  3. Degradation of the Bragg peak due to inhomogeneities.

    Science.gov (United States)

    Urie, M; Goitein, M; Holley, W R; Chen, G T

    1986-01-01

    The rapid fall-off of dose at the end of range of heavy charged particle beams has the potential in therapeutic applications of sparing critical structures just distal to the target volume. Here we explored the effects of highly inhomogeneous regions on this desirable depth-dose characteristic. The proton depth-dose distribution behind a lucite-air interface parallel to the beam was bimodal, indicating the presence of two groups of protons with different residual ranges, creating a step-like depth-dose distribution at the end of range. The residual ranges became more spread out as the interface was angled at 3 degrees, and still more at 6 degrees, to the direction of the beam. A second experiment showed little significant effect on the distal depth-dose of protons having passed through a mosaic of teflon and lucite. Anatomic studies demonstrated significant effects of complex fine inhomogeneities on the end of range characteristics. Monoenergetic protons passing through the petrous ridges and mastoid air cells in the base of skull showed a dramatic degradation of the distal Bragg peak. In beams with spread out Bragg peaks passing through regions of the base of skull, the distal fall-off from 90 to 20% dose was increased from its nominal 6 to well over 32 mm. Heavy ions showed a corresponding degradation in their ends of range. In the worst case in the base of skull region, a monoenergetic neon beam showed a broadening of the full width at half maximum of the Bragg peak to over 15 mm (compared with 4 mm in a homogeneous unit density medium). A similar effect was found with carbon ions in the abdomen, where the full width at half maximum of the Bragg peak (nominally 5.5 mm) was found to be greater than 25 mm behind gas-soft-tissue interfaces. We address the implications of these data for dose computation with heavy charged particles.

  4. Effect of gear ratio on peak power and time to peak power in BMX cyclists.

    Science.gov (United States)

    Rylands, Lee P; Roberts, Simon J; Hurst, Howard T

    2017-03-01

    The aim of this study was to ascertain if gear ratio selection would have an effect on peak power and time to peak power production in elite Bicycle Motocross (BMX) cyclists. Eight male elite BMX riders volunteered for the study. Each rider performed three, 10-s maximal sprints on an Olympic standard indoor BMX track. The riders' bicycles were fitted with a portable SRM power meter. Each rider performed the three sprints using gear ratios of 41/16, 43/16 and 45/16 tooth. The results from the 41/16 and 45/16 gear ratios were compared to the current standard 43/16 gear ratio. Statistically, significant differences were found between the gear ratios for peak power (F(2,14) = 6.448; p = .010) and peak torque (F(2,14) = 4.777; p = .026), but no significant difference was found for time to peak power (F(2,14) = 0.200; p = .821). When comparing gear ratios, the results showed a 45/16 gear ratio elicited the highest peak power,1658 ± 221 W, compared to 1436 ± 129 W and 1380 ± 56 W, for the 43/16 and 41/16 ratios, respectively. The time to peak power showed a 41/16 tooth gear ratio attained peak power in -0.01 s and a 45/16 in 0.22 s compared to the 43/16. The findings of this study suggest that gear ratio choice has a significant effect on peak power production, though time to peak power output is not significantly affected. Therefore, selecting a higher gear ratio results in riders attaining higher power outputs without reducing their start time.

  5. Improved peak shape fitting in alpha spectra.

    Science.gov (United States)

    Pommé, S; Caro Marroyo, B

    2015-02-01

    Peak overlap is a recurrent issue in alpha-particle spectrometry, not only in routine analyses but also in the high-resolution spectra from which reference values for alpha emission probabilities are derived. In this work, improved peak shape formulae are presented for the deconvolution of alpha-particle spectra. They have been implemented as fit functions in a spreadsheet application and optimum fit parameters were searched with built-in optimisation routines. Deconvolution results are shown for a few challenging spectra with high statistical precision. The algorithm outperforms the best available routines for high-resolution spectrometry, which may facilitate a more reliable determination of alpha emission probabilities in the future. It is also applicable to alpha spectra with inferior energy resolution. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  6. Peak Oil, Food Systems, and Public Health

    Science.gov (United States)

    Parker, Cindy L.; Kirschenmann, Frederick L.; Tinch, Jennifer; Lawrence, Robert S.

    2011-01-01

    Peak oil is the phenomenon whereby global oil supplies will peak, then decline, with extraction growing increasingly costly. Today's globalized industrial food system depends on oil for fueling farm machinery, producing pesticides, and transporting goods. Biofuels production links oil prices to food prices. We examined food system vulnerability to rising oil prices and the public health consequences. In the short term, high food prices harm food security and equity. Over time, high prices will force the entire food system to adapt. Strong preparation and advance investment may mitigate the extent of dislocation and hunger. Certain social and policy changes could smooth adaptation; public health has an essential role in promoting a proactive, smart, and equitable transition that increases resilience and enables adequate food for all. PMID:21778492

  7. First diffraction peak in alkali metaphosphate glasses

    Science.gov (United States)

    Beaufils, S.; Bionducci, M.; Ecolivet, C.; Marchand, R.; Le Sauze, A.

    2000-11-01

    The structure factor of the alkali metaphosphate glasses LiPO 3 and Na 0.5Li 0.5PO 3 has been measured at 300 K for both systems and up to 800 K for the latter. The first diffraction peak of alkali metaphosphate glasses merges at lower Q (around 1.1 Å -1) than in other covalent glasses, with the highest intensity for Li-containing glasses. These points are discussed following the hypothesis of voids ordering in the structure and contrasts effects due to the negative neutron Li scattering length. The intensity of the prepeak is significantly growing with temperature, in case of Na 0.5Li 0.5PO 3, in contrast to the other peaks of the structure factor. This point is discussed in relation with literature data from flow birefringence indicating structural changes in these glassy systems.

  8. Reducing Peak Power in Automated Weapon Laying

    Science.gov (United States)

    2016-02-01

    LAYING Joshua Stapp Matthew Tomik February 2016 Approved for public release; distribution is unlimited...PEAK POWER IN AUTOMATED WEAPON LAYING 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHORS Joshua Stapp and...aiming a weapon is referred to as gun laying . This report describes a method to calculate motion profiles that reach a given lay within the least

  9. METing SUSY on the Z peak

    International Nuclear Information System (INIS)

    Barenboim, G.; Bernabeu, J.; Vives, O.; Mitsou, V.A.; Romero, E.

    2016-01-01

    Recently the ATLAS experiment announced a 3 σ excess at the Z-peak consisting of 29 pairs of leptons together with two or more jets, E T miss > 225 GeV and HT > 600 GeV, to be compared with 10.6 ± 3.2 expected lepton pairs in the Standard Model. No excess outside the Z-peak was observed. By trying to explain this signal with SUSY we find that only relatively light gluinos, m g or similar 400 GeV decaying predominantly to Z-boson plus a light gravitino, such that nearly every gluino produces at least one Z-boson in its decay chain, could reproduce the excess. We construct an explicit general gauge mediation model able to reproduce the observed signal overcoming all the experimental limits. Needless to say, more sophisticated models could also reproduce the signal, however, any model would have to exhibit the following features: light gluinos, or heavy particles with a strong production cross section, producing at least one Z-boson in its decay chain. The implications of our findings for the Run II at LHC with the scaling on the Z peak, as well as for the direct search of gluinos and other SUSY particles, are pointed out. (orig.)

  10. Ten Reasons to Take Peak Oil Seriously

    Directory of Open Access Journals (Sweden)

    Robert J. Brecha

    2013-02-01

    Full Text Available Forty years ago, the results of modeling, as presented in The Limits to Growth, reinvigorated a discussion about exponentially growing consumption of natural resources, ranging from metals to fossil fuels to atmospheric capacity, and how such consumption could not continue far into the future. Fifteen years earlier, M. King Hubbert had made the projection that petroleum production in the continental United States would likely reach a maximum around 1970, followed by a world production maximum a few decades later. The debate about “peak oil”, as it has come to be called, is accompanied by some of the same vociferous denials, myths and ideological polemicizing that have surrounded later representations of The Limits to Growth. In this review, we present several lines of evidence as to why arguments for a near-term peak in world conventional oil production should be taken seriously—both in the sense that there is strong evidence for peak oil and in the sense that being societally unprepared for declining oil production will have serious consequences.

  11. METing SUSY on the Z peak

    Energy Technology Data Exchange (ETDEWEB)

    Barenboim, G.; Bernabeu, J.; Vives, O. [Universitat de Valencia, Departament de Fisica Teorica, Burjassot (Spain); Universitat de Valencia-CSIC, Parc Cientific U.V., IFIC, Paterna (Spain); Mitsou, V.A.; Romero, E. [Universitat de Valencia-CSIC, Parc Cientific U.V., IFIC, Paterna (Spain)

    2016-02-15

    Recently the ATLAS experiment announced a 3 σ excess at the Z-peak consisting of 29 pairs of leptons together with two or more jets, E{sub T}{sup miss} > 225 GeV and HT > 600 GeV, to be compared with 10.6 ± 3.2 expected lepton pairs in the Standard Model. No excess outside the Z-peak was observed. By trying to explain this signal with SUSY we find that only relatively light gluinos, m{sub g} or similar 400 GeV decaying predominantly to Z-boson plus a light gravitino, such that nearly every gluino produces at least one Z-boson in its decay chain, could reproduce the excess. We construct an explicit general gauge mediation model able to reproduce the observed signal overcoming all the experimental limits. Needless to say, more sophisticated models could also reproduce the signal, however, any model would have to exhibit the following features: light gluinos, or heavy particles with a strong production cross section, producing at least one Z-boson in its decay chain. The implications of our findings for the Run II at LHC with the scaling on the Z peak, as well as for the direct search of gluinos and other SUSY particles, are pointed out. (orig.)

  12. Practical load management - Peak shaving using photovoltaics; Peak Shaving mit der Fotovoltaik. Praktisches Lastmanagement

    Energy Technology Data Exchange (ETDEWEB)

    Berger, W.

    2009-07-01

    This article takes a look at how photovoltaic (PV) power generation can be used in a practical way to meet peak demands for electricity. Advice is provided on how photovoltaics can provide peak load 'shaving' through the correlation between its production and the peak loads encountered during the day. The situation regarding feed-in tariffs in Italy is discussed, as are further examples of installations in Germany and Austria. Further, an initiative of the American Southern California Edison utility is discussed which foresees the installation of large PV plant on the roofs of commercial premises to provide local generation of peak energy and thus relieve demands on their power transportation network.

  13. Contributions of Astronauts Aerobic Exercise Intensity and Time on Change in VO2peak during Spaceflight

    Science.gov (United States)

    Downs, Meghan E.; Buxton, Roxanne; Moore, Alan; Ploutz-Snyder, Robert; Ploutz-Snyder, Lori

    2014-01-01

    required to maintain VO2peak. As the FD105 average exercise intensity and time did not prevent a decline in VO2peak from preflight, astronauts' exercise prescriptions should target at least 160 min of weekly aerobic exercise at an average above 75% peak HR with increased time at intensities above 90% of peak HR starting early in the mission.

  14. Recent considerations of the GSI positron peaks

    International Nuclear Information System (INIS)

    Soff, G.; Reinhardt, J.; Reus, J. de; Ionescu, D.; Schramm, S.; Mueller, B.; Greiner, W.

    1987-08-01

    In this report we examine various attempts to explain the GSI positron peaks. After the presentation of recent experimental data we briefly sketch theoretical investigations concerning the new particle hypothesis. The failure of standard models employing a linear coupling led to more exotic scenarios for particle production. One exciting recent idea is outlined. After that we treat the possible formation of a resonance in ordinary Bhabha scattering which could represent a time-reversed channel to the observations in heavy-ion collisions. Finally we discuss the poly-positronium model and a purely atomic physics model to interprete the GSI positron events. (orig./HSI)

  15. Engineering training-success at Comanche Peak

    International Nuclear Information System (INIS)

    Oliver, M.G.; Preston, W.D.; McMahon, J.F.

    1993-01-01

    The engineering training program at Comanche Peak steam electric station (CPSES) has received favorable industry recognition. The Institute of Nuclear Power Operations has recommended the CPSES program as a source of information for plants trying to build their own successful programs and has featured the program in an article in the spring 1993 issue of The Nuclear Professional. The U.S. Nuclear Regulatory Commission described the program as superior in a preoperational review and assessment team inspection report and in the most recent systematic assessment of licensee performance. This industry recognition is an important measure of the program's success

  16. Electromechanical Peak Devices of Distributed Power Generation

    Directory of Open Access Journals (Sweden)

    S. V. Konstantinova

    2011-01-01

    Full Text Available The power world crises (1973, 1979 have demonstrated that mankind entered the expensive energy epoch. More and more attitude is given to power saving problem by including renewable power sources in energy balance of the countries. The paper analyzes a power system inBelarusand a typical chart of the active load is cited in the paper. Equalization of load chart is considered as one of measures directed on provision of higher operational efficiency of power system and power saving.  This purpose can be obtained while including electromechanical peak devices of the distributed generation in the energy balance.

  17. Particle creation by peak electric field

    Energy Technology Data Exchange (ETDEWEB)

    Adorno, T.C. [Tomsk State University, Department of Physics, Tomsk (Russian Federation); Gavrilov, S.P. [Tomsk State University, Department of Physics, Tomsk (Russian Federation); Herzen State Pedagogical University of Russia, Department of General and Experimental Physics, St. Petersburg (Russian Federation); Gitman, D.M. [Tomsk State University, Department of Physics, Tomsk (Russian Federation); P. N. Lebedev Physical Institute, Moscow (Russian Federation); University of Sao Paulo, Institute of Physics, CP 66318, Sao Paulo, SP (Brazil)

    2016-08-15

    The particle creation by the so-called peak electric field is considered. The latter field is a combination of two exponential parts, one exponentially increasing and another exponentially decreasing. We find exact solutions of the Dirac equation with the field under consideration with appropriate asymptotic conditions and calculate all the characteristics of particle creation effect, in particular, differential mean numbers of created particle, total number of created particles, and the probability for a vacuum to remain a vacuum. Characteristic asymptotic regimes are discussed in detail and a comparison with the pure asymptotically decaying field is considered. (orig.)

  18. Probable Values of Current Solar Cycle Peak

    Directory of Open Access Journals (Sweden)

    V. M. Silbergleit

    2012-01-01

    Full Text Available An analysis of multiple linear regression method applied to solar cycles 4 to 23 using lagged values of smoothed monthly mean sunspot numbers as independent variables is presented. According to that, the amplitude of current solar cycle 24 is estimated providing a quantitative prediction result. Our adjustment shows that the current cycle would have a sunspot peak less than the biggest one observed during the cycle 19 giving an additional support to the declination in solar activity which is currently happening.

  19. A non-parametric peak calling algorithm for DamID-Seq.

    Directory of Open Access Journals (Sweden)

    Renhua Li

    Full Text Available Protein-DNA interactions play a significant role in gene regulation and expression. In order to identify transcription factor binding sites (TFBS of double sex (DSX-an important transcription factor in sex determination, we applied the DNA adenine methylation identification (DamID technology to the fat body tissue of Drosophila, followed by deep sequencing (DamID-Seq. One feature of DamID-Seq data is that induced adenine methylation signals are not assured to be symmetrically distributed at TFBS, which renders the existing peak calling algorithms for ChIP-Seq, including SPP and MACS, inappropriate for DamID-Seq data. This challenged us to develop a new algorithm for peak calling. A challenge in peaking calling based on sequence data is estimating the averaged behavior of background signals. We applied a bootstrap resampling method to short sequence reads in the control (Dam only. After data quality check and mapping reads to a reference genome, the peaking calling procedure compromises the following steps: 1 reads resampling; 2 reads scaling (normalization and computing signal-to-noise fold changes; 3 filtering; 4 Calling peaks based on a statistically significant threshold. This is a non-parametric method for peak calling (NPPC. We also used irreproducible discovery rate (IDR analysis, as well as ChIP-Seq data to compare the peaks called by the NPPC. We identified approximately 6,000 peaks for DSX, which point to 1,225 genes related to the fat body tissue difference between female and male Drosophila. Statistical evidence from IDR analysis indicated that these peaks are reproducible across biological replicates. In addition, these peaks are comparable to those identified by use of ChIP-Seq on S2 cells, in terms of peak number, location, and peaks width.

  20. A non-parametric peak calling algorithm for DamID-Seq.

    Science.gov (United States)

    Li, Renhua; Hempel, Leonie U; Jiang, Tingbo

    2015-01-01

    Protein-DNA interactions play a significant role in gene regulation and expression. In order to identify transcription factor binding sites (TFBS) of double sex (DSX)-an important transcription factor in sex determination, we applied the DNA adenine methylation identification (DamID) technology to the fat body tissue of Drosophila, followed by deep sequencing (DamID-Seq). One feature of DamID-Seq data is that induced adenine methylation signals are not assured to be symmetrically distributed at TFBS, which renders the existing peak calling algorithms for ChIP-Seq, including SPP and MACS, inappropriate for DamID-Seq data. This challenged us to develop a new algorithm for peak calling. A challenge in peaking calling based on sequence data is estimating the averaged behavior of background signals. We applied a bootstrap resampling method to short sequence reads in the control (Dam only). After data quality check and mapping reads to a reference genome, the peaking calling procedure compromises the following steps: 1) reads resampling; 2) reads scaling (normalization) and computing signal-to-noise fold changes; 3) filtering; 4) Calling peaks based on a statistically significant threshold. This is a non-parametric method for peak calling (NPPC). We also used irreproducible discovery rate (IDR) analysis, as well as ChIP-Seq data to compare the peaks called by the NPPC. We identified approximately 6,000 peaks for DSX, which point to 1,225 genes related to the fat body tissue difference between female and male Drosophila. Statistical evidence from IDR analysis indicated that these peaks are reproducible across biological replicates. In addition, these peaks are comparable to those identified by use of ChIP-Seq on S2 cells, in terms of peak number, location, and peaks width.

  1. PeakVizor: Visual Analytics of Peaks in Video Clickstreams from Massive Open Online Courses.

    Science.gov (United States)

    Chen, Qing; Chen, Yuanzhe; Liu, Dongyu; Shi, Conglei; Wu, Yingcai; Qu, Huamin

    2016-10-01

    Massive open online courses (MOOCs) aim to facilitate open-access and massive-participation education. These courses have attracted millions of learners recently. At present, most MOOC platforms record the web log data of learner interactions with course videos. Such large amounts of multivariate data pose a new challenge in terms of analyzing online learning behaviors. Previous studies have mainly focused on the aggregate behaviors of learners from a summative view; however, few attempts have been made to conduct a detailed analysis of such behaviors. To determine complex learning patterns in MOOC video interactions, this paper introduces a comprehensive visualization system called PeakVizor. This system enables course instructors and education experts to analyze the "peaks" or the video segments that generate numerous clickstreams. The system features three views at different levels: the overview with glyphs to display valuable statistics regarding the peaks detected; the flow view to present spatio-temporal information regarding the peaks; and the correlation view to show the correlation between different learner groups and the peaks. Case studies and interviews conducted with domain experts have demonstrated the usefulness and effectiveness of PeakVizor, and new findings about learning behaviors in MOOC platforms have been reported.

  2. Energy solutions for CO2 emission peak and subsequent decline. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Soenderberg Petersen, L.; Larsen, Hans (eds.)

    2009-09-15

    The conference focused on: 1) Future global energy development options Scenario and policy issues. 2) Measures to achieve CO2 emission peak in 2015 - 2020 and subsequent decline. 3) Renewable energy supply technologies such as bioenergy, wind and solar. 4) Centralized energy technologies such as clean coal technologies. 5) Energy conversion, energy carriers and energy storage, including fuel cells and hydrogen technologies. 6) Providing renewable energy for the transport sector. 7) Systems aspects for the various regions throughout the world. 8) End-use technologies, efficiency improvements in supply and end use. 9) Energy savings. (au)

  3. Outreach Plans for Storm Peak Laboratory

    Science.gov (United States)

    Hallar, A. G.; McCubbin, I. B.

    2006-12-01

    The Desert Research Institute (DRI) operates a high elevation facility, Storm Peak Laboratory (SPL), located on the west summit of Mt. Werner in the Park Range near Steamboat Springs, Colorado at an elevation 10,500 ft. SPL provides an ideal location for long-term research on the interactions of atmospheric aerosol and gas- phase chemistry with cloud and natural radiation environments. SPL includes an office-type laboratory room for computer and instrumentation setup with outside air ports and cable access to the roof deck, a full kitchen and two bunk rooms with sleeping space for nine persons. We plan to create a unique summer undergraduate education experiences for students of diversity at Storm Peak Laboratory. As stressed by the College Pathways to Science Education Standards [Siebert and McIntosh, 2001], to support changes in K-12 science education transformations must first be made at the college level, including inquiry-oriented opportunities to engage in meaningful research. These workshops will be designed to allow students to experience the excitement of science, increasing their likelihood of pursing careers within the fields of scientific education or research.

  4. Peak heart rates at extreme altitudes

    DEFF Research Database (Denmark)

    Lundby, C; Van Hall, Gerrit

    2001-01-01

    We have measured maximal heart rate during a graded maximal bicycle exercise test to exhaustion in five healthy climbers before and during an expedition to Mt. Everest. Maximal heart rates at sea level were 186 (177-204) beats/min(-1) at sea level and 170 (169-182) beats/min(-1) with acute hypoxia....... After 1, 4 and 6 weeks of acclimatization to 5400 m, maximal heart rates were 155 (135-182), 158 (144-182), and 155 (140-183) beats/min(-1), respectively. Heart rates of two of the climbers were measured during their attempt to reach the summit of Mt. Everest without the use of supplemental oxygen....... The peak heart rates at 8,750 m for the two climbers were 142 and 144 beats/min(-1), which were similar to their maximal heart rates during exhaustive bicycle exercise at 5,400 m, the values being 144 and 148 beats/min(-1), respectively. The peak heart rates at 8,750 m are in agreement with other field...

  5. Monitoring device for local power peaking coefficient

    International Nuclear Information System (INIS)

    Mitsuhashi, Ishi

    1987-01-01

    Purpose: To monitor the local power peaking coefficients obtained by the method not depending on the combination of fuel types. Method: A plurality of representative values for the local power distribution determined by the nuclear constant calculation for one fuel assembly are memorized regarding each of the burn-up degree and the void coefficient on every positions and fuel types in fuel rod assemblies. While on the other hand, the representative values for the local power distribution as described above are compensated by a compensation coefficient considering the effect of adjacent segments and a control rod compensation coefficient considering the effect due to the control rod insertion relative to the just-mentioned compensation coefficient. Then, the maximum value among them is selected to determine the local power peaking coefficient at each of the times and each of the segments, which is monitored. According to this system, the calculation and the working required for the fitting work depending on the combination of fuel types are no more required at all to facilitate the maintenance as well. (Horiuchi, T.)

  6. Peak capacity and peak capacity per unit time in capillary and microchip zone electrophoresis.

    Science.gov (United States)

    Foley, Joe P; Blackney, Donna M; Ennis, Erin J

    2017-11-10

    The origins of the peak capacity concept are described and the important contributions to the development of that concept in chromatography and electrophoresis are reviewed. Whereas numerous quantitative expressions have been reported for one- and two-dimensional separations, most are focused on chromatographic separations and few, if any, quantitative unbiased expressions have been developed for capillary or microchip zone electrophoresis. Making the common assumption that longitudinal diffusion is the predominant source of zone broadening in capillary electrophoresis, analytical expressions for the peak capacity are derived, first in terms of migration time, diffusion coefficient, migration distance, and desired resolution, and then in terms of the remaining underlying fundamental parameters (electric field, electroosmotic and electrophoretic mobilities) that determine the migration time. The latter expressions clearly illustrate the direct square root dependence of peak capacity on electric field and migration distance and the inverse square root dependence on solute diffusion coefficient. Conditions that result in a high peak capacity will result in a low peak capacity per unit time and vice-versa. For a given symmetrical range of relative electrophoretic mobilities for co- and counter-electroosmotic species (cations and anions), the peak capacity increases with the square root of the electric field even as the temporal window narrows considerably, resulting in a significant reduction in analysis time. Over a broad relative electrophoretic mobility interval [-0.9, 0.9], an approximately two-fold greater amount of peak capacity can be generated for counter-electroosmotic species although it takes about five-fold longer to do so, consistent with the well-known bias in migration time and resolving power for co- and counter-electroosmotic species. The optimum lower bound of the relative electrophoretic mobility interval [μ r,Z , μ r,A ] that provides the maximum

  7. Technical Potential for Peak Load Management Programs in New Jersey

    Energy Technology Data Exchange (ETDEWEB)

    Kirby, B.J.

    2002-12-13

    Restructuring is attempting to bring the economic efficiency of competitive markets to the electric power industry. To at least some extent it is succeeding. New generation is being built in most areas of the country reversing the decades-long trend of declining reserve margins. Competition among generators is typically robust, holding down wholesale energy prices. Generators have shown that they are very responsive to price signals in both the short and long term. But a market that is responsive only on the supply side is only half a market. Demand response (elasticity) is necessary to gain the full economic advantages that restructuring can offer. Electricity is a form of energy that is difficult to store economically in large quantities. However, loads often have some ability to (1) conveniently store thermal energy and (2) defer electricity consumption. These inherent storage and control capabilities can be exploited to help reduce peak electric system consumption. In some cases they can also be used to provide system reliability reserves. Fortunately too, technology is helping. Advances in communications and control technologies are making it possible for loads ranging from residential through commercial and industrial to respond to economic signals. When we buy bananas, we don't simply take a dozen and wait a month to find out what the price was. We always ask about the price before we decide how many bananas we want. Technology is beginning to allow at least some customers to think about their electricity consumption the same way they think about most of their other purchases. And power system operators and regulators are beginning to understand that customers need to remain in control of their own destinies. Many customers (residential through industrial) are willing to respond to price signals. Most customers are not able to commit to specific responses months or years in advance. Electricity is a fluid market commodity with a volatile value to both

  8. Peak Wind Tool for General Forecasting

    Science.gov (United States)

    Barrett, Joe H., III

    2010-01-01

    The expected peak wind speed of the day is an important forecast element in the 45th Weather Squadron's (45 WS) daily 24-Hour and Weekly Planning Forecasts. The forecasts are used for ground and space launch operations at the Kennedy Space Center (KSC) and Cape Canaveral Air Force Station (CCAFS). The 45 WS also issues wind advisories for KSC/CCAFS when they expect wind gusts to meet or exceed 25 kt, 35 kt and 50 kt thresholds at any level from the surface to 300 ft. The 45 WS forecasters have indicated peak wind speeds are challenging to forecast, particularly in the cool season months of October - April. In Phase I of this task, the Applied Meteorology Unit (AMU) developed a tool to help the 45 WS forecast non-convective winds at KSC/CCAFS for the 24-hour period of 0800 to 0800 local time. The tool was delivered as a Microsoft Excel graphical user interface (GUI). The GUI displayed the forecast of peak wind speed, 5-minute average wind speed at the time of the peak wind, timing of the peak wind and probability the peak speed would meet or exceed 25 kt, 35 kt and 50 kt. For the current task (Phase II ), the 45 WS requested additional observations be used for the creation of the forecast equations by expanding the period of record (POR). Additional parameters were evaluated as predictors, including wind speeds between 500 ft and 3000 ft, static stability classification, Bulk Richardson Number, mixing depth, vertical wind shear, temperature inversion strength and depth and wind direction. Using a verification data set, the AMU compared the performance of the Phase I and II prediction methods. Just as in Phase I, the tool was delivered as a Microsoft Excel GUI. The 45 WS requested the tool also be available in the Meteorological Interactive Data Display System (MIDDS). The AMU first expanded the POR by two years by adding tower observations, surface observations and CCAFS (XMR) soundings for the cool season months of March 2007 to April 2009. The POR was expanded

  9. Control of the Peak Linear Power by Using Two Kinds of Fuel Rods in the AHR

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Chul Gyo; Park, Cheol; Lee, Choong Sung; Kim, Hark Sung; Chae, Hee Taek [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2007-07-01

    Korea Atomic Energy Research Institute (KAERI) is developing an Advanced HANARO research Reactor (AHR) based on the HANARO experiences through its design to operation stages. AHR will be a 20 MW multi purpose research reactor and loaded with the HANARO fuel assemblies of a rod type. AHR has a compact core with a high power density for achieving a high neutron flux that is most important in a research reactor. As the average power is high, the control of the peak linear power is very important. The reference core of the AHR shows an acceptable peak linear power in the fresh core. In the equilibrium core, the peak linear power had been assumed to be low. A recent evaluation shows that the peak linear power in the equilibrium core exceeds the target limit. The evaluation was performed with the HELIOS / VENTURE code system and is suspected to be overestimated when compared with the result by the MCNP code in the fresh core. The modeling and fuel management scheme will be improved. Fundamentally, measures to lower the high peak linear power should be prepared. HANARO uses two kinds of fuel rods for reducing the peak linear power. It is expected that the same method will work well in the AHR. This paper introduces measures to control the peak linear power including the adaptation of two kinds of fuel rods and evaluates the peak linear power for the equilibrium core using a Monte Carlo burn-up system.

  10. Peaking for optimal performance: Research limitations and future directions.

    Science.gov (United States)

    Pyne, David B; Mujika, Iñigo; Reilly, Thomas

    2009-02-01

    A key element of the physical preparation of athletes is the taper period in the weeks immediately preceding competition. Existing research has defined the taper, identified various forms used in contemporary sport, and examined the prescription of training volume, load, intensity, duration, and type (progressive or step). Current limitations include: the lack of studies on team, combative, racquet, and precision (target) sports; the relatively small number of randomized controlled trials; the narrow focus on a single competition (single peak) compared with multiple peaking for weekly, multi-day or multiple events; and limited understanding of the physiological, neuromuscular, and biomechanical basis of the taper. Future research should address these limitations, together with the influence of prior training on optimal tapering strategies, and the interactions between the taper and long-haul travel, heat, and altitude. Practitioners seek information on how to prescribe tapers from season to season during an athlete's career, or a team's progression through a domestic league season, or multi-year Olympic or World Cup cycle. Practical guidelines for planning effective tapers for the Vancouver 2010 and London 2012 Olympics will evolve from both experimental investigations and modelling of successful tapers currently employed in a wide range of sports.

  11. Combining automated peak tracking in SAR by NMR with structure-based backbone assignment from 15N-NOESY

    KAUST Repository

    Jang, Richard

    2012-03-21

    Background: Chemical shift mapping is an important technique in NMR-based drug screening for identifying the atoms of a target protein that potentially bind to a drug molecule upon the molecule\\'s introduction in increasing concentrations. The goal is to obtain a mapping of peaks with known residue assignment from the reference spectrum of the unbound protein to peaks with unknown assignment in the target spectrum of the bound protein. Although a series of perturbed spectra help to trace a path from reference peaks to target peaks, a one-to-one mapping generally is not possible, especially for large proteins, due to errors, such as noise peaks, missing peaks, missing but then reappearing, overlapped, and new peaks not associated with any peaks in the reference. Due to these difficulties, the mapping is typically done manually or semi-automatically, which is not efficient for high-throughput drug screening.Results: We present PeakWalker, a novel peak walking algorithm for fast-exchange systems that models the errors explicitly and performs many-to-one mapping. On the proteins: hBclXL, UbcH5B, and histone H1, it achieves an average accuracy of over 95% with less than 1.5 residues predicted per target peak. Given these mappings as input, we present PeakAssigner, a novel combined structure-based backbone resonance and NOE assignment algorithm that uses just 15N-NOESY, while avoiding TOCSY experiments and 13C-labeling, to resolve the ambiguities for a one-to-one mapping. On the three proteins, it achieves an average accuracy of 94% or better.Conclusions: Our mathematical programming approach for modeling chemical shift mapping as a graph problem, while modeling the errors directly, is potentially a time- and cost-effective first step for high-throughput drug screening based on limited NMR data and homologous 3D structures. 2012 Jang et al.; licensee BioMed Central Ltd.

  12. Peak Electric Load Relief in Northern Manhattan

    Directory of Open Access Journals (Sweden)

    Hildegaard D. Link

    2014-08-01

    Full Text Available The aphorism “Think globally, act locally,” attributed to René Dubos, reflects the vision that the solution to global environmental problems must begin with efforts within our communities. PlaNYC 2030, the New York City sustainability plan, is the starting point for this study. Results include (a a case study based on the City College of New York (CCNY energy audit, in which we model the impacts of green roofs on campus energy demand and (b a case study of energy use at the neighborhood scale. We find that reducing the urban heat island effect can reduce building cooling requirements, peak electricity loads stress on the local electricity grid and improve urban livability.

  13. Comparison of five portable peak flow meters

    Directory of Open Access Journals (Sweden)

    Glaucia Nency Takara

    2010-01-01

    Full Text Available OBJECTIVE: To compare the measurements of spirometric peak expiratory flow (PEF from five different PEF meters and to determine if their values are in agreement. Inaccurate equipment may result in incorrect diagnoses of asthma and inappropriate treatments. METHODS: Sixty-eight healthy, sedentary and insufficiently active subjects, aged from 19 to 40 years, performed PEF measurements using Air Zone®, Assess®, Galemed®, Personal Best® and Vitalograph® peak flow meters. The highest value recorded for each subject for each device was compared to the corresponding spirometric values using Friedman's test with Dunn's post-hoc (p<0.05, Spearman's correlation test and Bland-Altman's agreement test. RESULTS: The median and interquartile ranges for the spirometric values and the Air Zone®, Assess®, Galemed®, Personal Best® and Vitalograph® meters were 428 (263-688 L/min, 450 (350-800 L/min, 420 (310-720 L/min, 380 (300-735 L/min, 400 (310-685 L/min and 415 (335-610 L/min, respectively. Significant differences were found when the spirometric values were compared to those recorded by the Air Zone® (p<0.001 and Galemed ® (p<0.01 meters. There was no agreement between the spirometric values and the five PEF meters. CONCLUSIONS: The results suggest that the values recorded from Galemed® meters may underestimate the actual value, which could lead to unnecessary interventions, and that Air Zone® meters overestimate spirometric values, which could obfuscate the need for intervention. These findings must be taken into account when interpreting both devices' results in younger people. These differences should also be considered when directly comparing values from different types of PEF meters.

  14. Comparison of five portable peak flow meters.

    Science.gov (United States)

    Takara, Glaucia Nency; Ruas, Gualberto; Pessoa, Bruna Varanda; Jamami, Luciana Kawakami; Di Lorenzo, Valéria Amorim Pires; Jamami, Mauricio

    2010-05-01

    To compare the measurements of spirometric peak expiratory flow (PEF) from five different PEF meters and to determine if their values are in agreement. Inaccurate equipment may result in incorrect diagnoses of asthma and inappropriate treatments. Sixty-eight healthy, sedentary and insufficiently active subjects, aged from 19 to 40 years, performed PEF measurements using Air Zone, Assess, Galemed, Personal Best and Vitalograph peak flow meters. The highest value recorded for each subject for each device was compared to the corresponding spirometric values using Friedman's test with Dunn's post-hoc (p<0.05), Spearman's correlation test and Bland-Altman's agreement test. The median and interquartile ranges for the spirometric values and the Air Zone, Assess, Galemed, Personal Best and Vitalograph meters were 428 (263-688 L/min), 450 (350-800 L/min), 420 (310-720 L/min), 380 (300-735 L/min), 400 (310-685 L/min) and 415 (335-610 L/min), respectively. Significant differences were found when the spirometric values were compared to those recorded by the Air Zone(R) (p<0.001) and Galemed (p<0.01) meters. There was no agreement between the spirometric values and the five PEF meters. The results suggest that the values recorded from Galemed meters may underestimate the actual value, which could lead to unnecessary interventions, and that Air Zone meters overestimate spirometric values, which could obfuscate the need for intervention. These findings must be taken into account when interpreting both devices' results in younger people. These differences should also be considered when directly comparing values from different types of PEF meters.

  15. Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension

    DEFF Research Database (Denmark)

    Göransson, Christoffer; Vejlstrup, Niels; Carlsen, Jørn

    2018-01-01

    Right ventricular (RV) and left ventricular (LV) diastolic stiffness may be independent contributors to disease progression in pulmonary arterial hypertension (PAH). The aims of this study are to assess reproducibility of peak emptying rate (PER) and early diastolic peak filling rate (PFR) for both.......01]) and in the LV (PAH = 209 mL/m2/s, controls = 311 mL/m2/s [p sample size of ... with stroke volume (all four: p sample sizes for trials of therapies targeting diastolic dysfunction to increase survival....

  16. Emission scenarios in the face of fossil-fuel peaking

    International Nuclear Information System (INIS)

    Brecha, Robert J.

    2008-01-01

    Emissions scenarios used by the Intergovernmental Panel on Climate Change (IPCC) are based on detailed energy system models in which demographics, technology and economics are used to generate projections of future world energy consumption, and therefore, of greenhouse gas emissions. We propose in this paper that it is useful to look at a qualitative model of the energy system, backed by data from short- and medium-term trends, to gain a sense of carbon emission bounds. Here we look at what may be considered a lower bound for 21st century emissions given two assumptions: first, that extractable fossil-fuel resources follow the trends assumed by 'peak oil' adherents, and second, that no climate mitigation policies are put in place to limit emissions. If resources, and more importantly, extraction rates, of fossil fuels are more limited than posited in full energy-system models, a supply-driven emissions scenario results; however, we show that even in this 'peak fossil-fuel' limit, carbon emissions are high enough to surpass 550 ppm or 2 C climate protection guardrails. Some indicators are presented that the scenario presented here should not be disregarded, and comparisons are made to the outputs of emission scenarios used for the IPCC reports. (author)

  17. Peak expiratory flow rate and Pulse Pressure values during the ...

    African Journals Online (AJOL)

    This study assessed the peak expiratory flow rate and pulse pressure during the luteal and menstruation phases of the menstrual cycle. The peak expiratory flow rate and pulse pressure were measured using the Wright's Peak Flow Meter and Mercury Sphygmomanometer respectively. The peak expiratory flow rate and ...

  18. Logistic curves, extraction costs and effective peak oil

    International Nuclear Information System (INIS)

    Brecha, Robert J.

    2012-01-01

    Debates about the possibility of a near-term maximum in world oil production have become increasingly prominent over the past decade, with the focus often being on the quantification of geologically available and technologically recoverable amounts of oil in the ground. Economically, the important parameter is not a physical limit to resources in the ground, but whether market price signals and costs of extraction will indicate the efficiency of extracting conventional or nonconventional resources as opposed to making substitutions over time for other fuels and technologies. We present a hybrid approach to the peak-oil question with two models in which the use of logistic curves for cumulative production are supplemented with data on projected extraction costs and historical rates of capacity increase. While not denying the presence of large quantities of oil in the ground, even with foresight, rates of production of new nonconventional resources are unlikely to be sufficient to make up for declines in availability of conventional oil. Furthermore we show how the logistic-curve approach helps to naturally explain high oil prices even when there are significant quantities of low-cost oil yet to be extracted. - Highlights: ► Extraction cost information together with logistic curves to model oil extraction. ► Two models of extraction sequence for different oil resources. ► Importance of time-delay and extraction rate limits for new resources. ► Model results qualitatively reproduce observed extraction cost dynamics. ► Confirmation of “effective” peak oil, even though resources are in ground.

  19. Peak-valley-peak pattern of histone modifications delineates active regulatory elements and their directionality

    DEFF Research Database (Denmark)

    Pundhir, Sachin; Bagger, Frederik Otzen; Lauridsen, Felicia Kathrine Bratt

    2016-01-01

    Formation of nucleosome free region (NFR) accompanied by specific histone modifications at flanking nucleosomes is an important prerequisite for enhancer and promoter activity. Due to this process, active regulatory elements often exhibit a distinct shape of histone signal in the form of a peak......-valley-peak (PVP) pattern. However, different features of PVP patterns and their robustness in predicting active regulatory elements have never been systematically analyzed. Here, we present PARE, a novel computational method that systematically analyzes the H3K4me1 or H3K4me3 PVP patterns to predict NFRs. We show...

  20. Interpreting comprehensive two-dimensional gas chromatography using peak topography maps with application to petroleum forensics.

    Science.gov (United States)

    Ghasemi Damavandi, Hamidreza; Sen Gupta, Ananya; Nelson, Robert K; Reddy, Christopher M

    2016-01-01

    Comprehensive two-dimensional gas chromatography [Formula: see text] provides high-resolution separations across hundreds of compounds in a complex mixture, thus unlocking unprecedented information for intricate quantitative interpretation. We exploit this compound diversity across the [Formula: see text] topography to provide quantitative compound-cognizant interpretation beyond target compound analysis with petroleum forensics as a practical application. We focus on the [Formula: see text] topography of biomarker hydrocarbons, hopanes and steranes, as they are generally recalcitrant to weathering. We introduce peak topography maps (PTM) and topography partitioning techniques that consider a notably broader and more diverse range of target and non-target biomarker compounds compared to traditional approaches that consider approximately 20 biomarker ratios. Specifically, we consider a range of 33-154 target and non-target biomarkers with highest-to-lowest peak ratio within an injection ranging from 4.86 to 19.6 (precise numbers depend on biomarker diversity of individual injections). We also provide a robust quantitative measure for directly determining "match" between samples, without necessitating training data sets. We validate our methods across 34 [Formula: see text] injections from a diverse portfolio of petroleum sources, and provide quantitative comparison of performance against established statistical methods such as principal components analysis (PCA). Our data set includes a wide range of samples collected following the 2010 Deepwater Horizon disaster that released approximately 160 million gallons of crude oil from the Macondo well (MW). Samples that were clearly collected following this disaster exhibit statistically significant match [Formula: see text] using PTM-based interpretation against other closely related sources. PTM-based interpretation also provides higher differentiation between closely correlated but distinct sources than obtained using

  1. Film coated tablets (ColoPulse technology) for targeted delivery in the lower intestinal tract : influence of the core composition on release characteristics

    NARCIS (Netherlands)

    Schellekens, Reinout C. A.; Baltink, Jan H.; Woesthuis, Ellen M.; Stellaard, Frans; Kosterink, Jos G. W.; Woerdenbag, Herman J.; Frijlink, Henderik W.

    2010-01-01

    The design of a film coating technology which allows a tablet to deliver the drug in the ileocolonic segment would offer new treatment possibilities. The objective is to develop a platform technology that is suitable for a broad range of drug compounds. We developed a coated tablet with a delayed,

  2. Target support for inertial confinement fusion

    International Nuclear Information System (INIS)

    Schultz, K.R.

    1995-08-01

    General Atomics (GA) plays an important industrial support role for the US Inertial Confinement Fusion (ICF) program in the area of target technology. This includes three major activities: target fabrication support, target handling systems development, and target chamber design. The work includes target fabrication for existing ICF experiments, target and target system development for future experiments, and target research and target chamber design for experiments on future machines, such as the National Ignition Facility (NIF)

  3. OccuPeak: ChIP-Seq peak calling based on internal background modelling

    NARCIS (Netherlands)

    de Boer, Bouke A.; van Duijvenboden, Karel; van den Boogaard, Malou; Christoffels, Vincent M.; Barnett, Phil; Ruijter, Jan M.

    2014-01-01

    ChIP-seq has become a major tool for the genome-wide identification of transcription factor binding or histone modification sites. Most peak-calling algorithms require input control datasets to model the occurrence of background reads to account for local sequencing and GC bias. However, the

  4. Can You Hear That Peak? Utilization of Auditory and Visual Feedback at Peak Limb Velocity

    Science.gov (United States)

    Loria, Tristan; de Grosbois, John; Tremblay, Luc

    2016-01-01

    Purpose: At rest, the central nervous system combines and integrates multisensory cues to yield an optimal percept. When engaging in action, the relative weighing of sensory modalities has been shown to be altered. Because the timing of peak velocity is the critical moment in some goal-directed movements (e.g., overarm throwing), the current study…

  5. Residential implementation of critical-peak pricing of electricity

    International Nuclear Information System (INIS)

    Herter, Karen

    2007-01-01

    This paper investigates how critical-peak pricing (CPP) affects households with different usage and income levels, with the goal of informing policy makers who are considering the implementation of CPP tariffs in the residential sector. Using a subset of data from the California Statewide Pricing Pilot of 2003-04, average load change during summer events, annual percent bill change, and post-experiment satisfaction ratings are calculated across six customer segments, categorized by historical usage and income levels. Findings show that high-use customers respond significantly more in kW reduction than do low-use customers, while low-use customers save significantly more in percentage reduction of annual electricity bills than do high-use customers-results that challenge the strategy of targeting only high-use customers for CPP tariffs. Across income levels, average load and bill changes were statistically indistinguishable, as were satisfaction rates-results that are compatible with a strategy of full-scale implementation of CPP rates in the residential sector. Finally, the high-use customers earning less than $50,000 annually were the most likely of the groups to see bill increases-about 5% saw bill increases of 10% or more-suggesting that any residential CPP implementation might consider targeting this customer group for increased energy efficiency efforts

  6. Lander petal & Twin Peaks - 3D

    Science.gov (United States)

    1997-01-01

    Many prominent rocks near the Sagan Memorial Station are featured in this image, taken in stereo by the Imager for Mars Pathfinder (IMP) on Sol 3. 3D glasses are necessary to identify surface detail. The two hills in the distance, approximately one to two kilometers away, have been dubbed the 'Twin Peaks' and are of great interest to Pathfinder scientists as objects of future study. The white areas on the left hill, called the 'Ski Run' by scientists, may have been formed by hydrologic processes. A lander petal, airbag, and the rear ramp are at the lower area of the image.The image was taken by the Imager for Mars Pathfinder (IMP) after its deployment on Sol 3. Mars Pathfinder was developed and managed by the Jet Propulsion Laboratory (JPL) for the National Aeronautics and Space Administration. The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.Click below to see the left and right views individually. [figure removed for brevity, see original site] Left [figure removed for brevity, see original site] Right

  7. Prediction of iodine activity peak during refuelling

    International Nuclear Information System (INIS)

    Hozer, Z.; Vajda, N.

    2001-01-01

    The increase of fission product activities in the primary circuit of a nuclear power plant indicates the existence of defects in some fuel rods. The power change leads to the cooling down of the fuel and results in the fragmentation of the UO 2 pellets, which facilitates the release of fission products from the intergranular regions. Furthermore the injection of boric acid after shutdown will increase the primary activity, due to the solution of deposited fission products from the surface of the core components. The calculation of these phenomena usually is based on the evaluation of activity measurements and power plant data. The estimation of iodine spiking peak during reactor transients is based on correlation with operating parameters, such as reactor power and primary pressure. The approach used in the present method was applied for CANDU reactors. The VVER-440 specific correlations were determined using the activity measurements of the Paks NPP and the data provided by the Russian fuel supplier. The present method is used for the evaluation of the iodine isotopes, as well as the noble gases. A numerical model has been developed for iodine spiking simulation and has been validated against several shutdown transients, measured at Paks NPP. (R.P.)

  8. Human behavioral complexity peaks at age 25

    Science.gov (United States)

    Brugger, Peter

    2017-01-01

    Random Item Generation tasks (RIG) are commonly used to assess high cognitive abilities such as inhibition or sustained attention. They also draw upon our approximate sense of complexity. A detrimental effect of aging on pseudo-random productions has been demonstrated for some tasks, but little is as yet known about the developmental curve of cognitive complexity over the lifespan. We investigate the complexity trajectory across the lifespan of human responses to five common RIG tasks, using a large sample (n = 3429). Our main finding is that the developmental curve of the estimated algorithmic complexity of responses is similar to what may be expected of a measure of higher cognitive abilities, with a performance peak around 25 and a decline starting around 60, suggesting that RIG tasks yield good estimates of such cognitive abilities. Our study illustrates that very short strings of, i.e., 10 items, are sufficient to have their complexity reliably estimated and to allow the documentation of an age-dependent decline in the approximate sense of complexity. PMID:28406953

  9. Human behavioral complexity peaks at age 25.

    Directory of Open Access Journals (Sweden)

    Nicolas Gauvrit

    2017-04-01

    Full Text Available Random Item Generation tasks (RIG are commonly used to assess high cognitive abilities such as inhibition or sustained attention. They also draw upon our approximate sense of complexity. A detrimental effect of aging on pseudo-random productions has been demonstrated for some tasks, but little is as yet known about the developmental curve of cognitive complexity over the lifespan. We investigate the complexity trajectory across the lifespan of human responses to five common RIG tasks, using a large sample (n = 3429. Our main finding is that the developmental curve of the estimated algorithmic complexity of responses is similar to what may be expected of a measure of higher cognitive abilities, with a performance peak around 25 and a decline starting around 60, suggesting that RIG tasks yield good estimates of such cognitive abilities. Our study illustrates that very short strings of, i.e., 10 items, are sufficient to have their complexity reliably estimated and to allow the documentation of an age-dependent decline in the approximate sense of complexity.

  10. Fast clustering using adaptive density peak detection.

    Science.gov (United States)

    Wang, Xiao-Feng; Xu, Yifan

    2017-12-01

    Common limitations of clustering methods include the slow algorithm convergence, the instability of the pre-specification on a number of intrinsic parameters, and the lack of robustness to outliers. A recent clustering approach proposed a fast search algorithm of cluster centers based on their local densities. However, the selection of the key intrinsic parameters in the algorithm was not systematically investigated. It is relatively difficult to estimate the "optimal" parameters since the original definition of the local density in the algorithm is based on a truncated counting measure. In this paper, we propose a clustering procedure with adaptive density peak detection, where the local density is estimated through the nonparametric multivariate kernel estimation. The model parameter is then able to be calculated from the equations with statistical theoretical justification. We also develop an automatic cluster centroid selection method through maximizing an average silhouette index. The advantage and flexibility of the proposed method are demonstrated through simulation studies and the analysis of a few benchmark gene expression data sets. The method only needs to perform in one single step without any iteration and thus is fast and has a great potential to apply on big data analysis. A user-friendly R package ADPclust is developed for public use.

  11. Contribution of ICT to Climate Targets of Cities. Exploring the potential of Information and Communication Technologies in reducing emissions and energy use from buildings and travel

    Energy Technology Data Exchange (ETDEWEB)

    Kramers, Anna

    2012-07-01

    This thesis examines how ICT solutions can assist in lowering energy use and greenhouse gas (GHG) emissions from buildings and travel in order to help cities meet their climate targets. It also provides an overview of relevant research intended to furnish new knowledge about the issues involved and to find solutions to social problems. The first part of the thesis provides an analysis and compilation of critical system boundaries that need to be used for cities to set targets for energy use and GHG emissions. The climate targets of cities are dependent on setting system boundaries and establishing methods of calculations for monitoring whether the targets have been achieved. Today, there is no official standard for how the system boundaries must be set or what calculation methodologies to apply to evaluate the climate targets. Four main categories of system boundaries were identified: the temporal scope, the object of target setting, the unit of target setting, and the target range (e.g. consumer-producer and lifecycle perspective). Eight European cities were examined in relation to how they set climate targets. The examination showed that awareness of what is included in the targets is limited and that there is a need for standardised and consistent protocols and methods of setting climate targets for cities. In the second part of the thesis, leading Advanced Traveller Information Systems (ATIS) and their functionalities were investigated. The relationship between individual decisions on different travel modes and functionalities of ATIS was investigated through a systematic investigation of the functionality of nine ATIS, mainly from Sweden, Germany, UK and USA. This allowed decisions that could lead to lower energy use and emissions of GHG to be identified. It also resulted in a proposal on requirements for new and improved functionality that could support a reduction in energy use and GHG emissions and a shift to renewable energy sources if implemented in next

  12. Target Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — [Part of the ATLAS user facility.] The Physics Division operates a target development laboratory that produces targets and foils of various thickness and substrates,...

  13. Quantifying the effects of zoned cooling systems on household peak electricity demand

    Energy Technology Data Exchange (ETDEWEB)

    Lomanowski, Bartosz; Haddad, Kamel [Cammet, Natural Resources Canada, Ottawa, ON (Canada)

    2010-07-01

    In Canada, significant temperature changes occur during the year with important peaks. Most residential apartments use a single thermostat to control heating and cooling, however those systems result in unbalanced delivery and high costs. The aim of this study is to evaluate the potential benefits of a zoned cooling system during peak summer days. A building energy simulation model was developed and simulations were performed on the Canadian Centre for Housing Technology's representative test house with different control strategies for peak summer days in Southern Ontario. Results showed that the effectiveness of a control strategy depends on the capacity of the system to meet the peak loads and that gradually decreasing the set point is better than a sudden drop. In addition, the implementation of passive cooling measures was found to reduce power consumption considerably and increase the effectiveness of the control strategy.

  14. High sensitive LPFG magnetic field sensor based on dual-peak resonance

    Science.gov (United States)

    Gu, Zhengtian; Ling, Qiang; Lan, Jinlong; Gao, Kan

    2017-11-01

    A high sensitivity magnetic field sensor based on magnetic-fluid-clad LPFG structure with dual peak resonance is presented and experimentally investigated. Based on coupled mode theory, the sensing principle of this sensor is originated from the sensibility of the dual peak based LPFG to the environment refractive index. In experiment, a dual peak interval change was available to 38 nm with a magnetic field strength varying from 0 to 12 mT when the temperature was 17.3 °C, and the dual peak interval displays a cubic polynomial dependence with the magnetic field strength at the low field regime. The sensitivity of this sensor to the magnetic field can be available to 4.08 nm/mT, and it is one order and two orders of magnitude higher than that of the sensors based on MSM and SMS fiber structure, respectively. The novel sensor has many advantages of simple technology, structure stability and high sensitivity.

  15. Research Opportunities at Storm Peak Laboratory

    Science.gov (United States)

    Hallar, A. G.; McCubbin, I. B.

    2006-12-01

    The Desert Research Institute (DRI) operates a high elevation facility, Storm Peak Laboratory (SPL), located on the west summit of Mt. Werner in the Park Range near Steamboat Springs, Colorado at an elevation of 3210 m MSL (Borys and Wetzel, 1997). SPL provides an ideal location for long-term research on the interactions of atmospheric aerosol and gas- phase chemistry with cloud and natural radiation environments. The ridge-top location produces almost daily transition from free tropospheric to boundary layer air which occurs near midday in both summer and winter seasons. Long-term observations at SPL document the role of orographically induced mixing and convection on vertical pollutant transport and dispersion. During winter, SPL is above cloud base 25% of the time, providing a unique capability for studying aerosol-cloud interactions (Borys and Wetzel, 1997). A comprehensive set of continuous aerosol measurements was initiated at SPL in 2002. SPL includes an office-type laboratory room for computer and instrumentation setup with outside air ports and cable access to the roof deck, a cold room for precipitation and cloud rime ice sample handling and ice crystal microphotography, a 150 m2 roof deck area for outside sampling equipment, a full kitchen and two bunk rooms with sleeping space for nine persons. The laboratory is currently well equipped for aerosol and cloud measurements. Particles are sampled from an insulated, 15 cm diameter manifold within approximately 1 m of its horizontal entry point through an outside wall. The 4 m high vertical section outside the building is capped with an inverted can to exclude large particles.

  16. Cultural targeting and tailoring of shared decision making technology: a theoretical framework for improving the effectiveness of patient decision aids in culturally diverse groups.

    Science.gov (United States)

    Alden, Dana L; Friend, John; Schapira, Marilyn; Stiggelbout, Anne

    2014-03-01

    Patient decision aids are known to positively impact outcomes critical to shared decision making (SDM), such as gist knowledge and decision preparedness. However, research on the potential improvement of these and other important outcomes through cultural targeting and tailoring of decision aids is very limited. This is the case despite extensive evidence supporting use of cultural targeting and tailoring to improve the effectiveness of health communications. Building on prominent psychological theory, we propose a two-stage framework incorporating cultural concepts into the design process for screening and treatment decision aids. The first phase recommends use of cultural constructs, such as collectivism and individualism, to differentially target patients whose cultures are known to vary on these dimensions. Decision aid targeting is operationalized through use of symbols and values that appeal to members of the given culture. Content dimensions within decision aids that appear particularly appropriate for targeting include surface level visual characteristics, language, beliefs, attitudes and values. The second phase of the framework is based on evidence that individuals vary in terms of how strongly cultural norms influence their approach to problem solving and decision making. In particular, the framework hypothesizes that differences in terms of access to cultural mindsets (e.g., access to interdependent versus independent self) can be measured up front and used to tailor decision aids. Thus, the second phase in the framework emphasizes the importance of not only targeting decision aid content, but also tailoring the information to the individual based on measurement of how strongly he/she is connected to dominant cultural mindsets. Overall, the framework provides a theory-based guide for researchers and practitioners who are interested in using cultural targeting and tailoring to develop and test decision aids that move beyond a "one-size fits all" approach

  17. Price, environment and security: Exploring multi-modal motivation in voluntary residential peak demand response

    International Nuclear Information System (INIS)

    Gyamfi, Samuel; Krumdieck, Susan

    2011-01-01

    Peak demand on electricity grids is a growing problem that increases costs and risks to supply security. Residential sector loads often contribute significantly to seasonal and daily peak demand. Demand response projects aim to manage peak demand by applying price signals and automated load shedding technologies. This research investigates voluntary load shedding in response to information about the security of supply, the emission profile and the cost of meeting critical peak demand in the customers' network. Customer willingness to change behaviour in response to this information was explored through mail-back survey. The diversified demand modelling method was used along with energy audit data to estimate the potential peak load reduction resulting from the voluntary demand response. A case study was conducted in a suburb of Christchurch, New Zealand, where electricity is the main source for water and space heating. On this network, all water heating cylinders have ripple-control technology and about 50% of the households subscribe to differential day/night pricing plan. The survey results show that the sensitivity to supply security is on par with price, with the emission sensitivity being slightly weaker. The modelling results show potential 10% reduction in critical peak load for aggregate voluntary demand response. - Highlights: → Multiple-factor behaviour intervention is necessarily for effective residential demand response. → Security signals can achieve result comparable to price. → The modelling results show potential 10% reduction in critical peak load for aggregate voluntary demand response. → New Zealand's energy policy should include innovation and development of VDR programmes and technologies.

  18. Choquet and Shilov Boundaries, Peak Sets, and Peak Points for Real Banach Function Algebras

    Directory of Open Access Journals (Sweden)

    Davood Alimohammadi

    2013-01-01

    Full Text Available Let be a compact Hausdorff space and let be a topological involution on . In 1988, Kulkarni and Arundhathi studied Choquet and Shilov boundaries for real uniform function algebras on . Then in 2000, Kulkarni and Limaye studied the concept of boundaries and Choquet sets for uniformly closed real subspaces and subalgebras of or . In 1971, Dales obtained some properties of peak sets and p-sets for complex Banach function algebras on . Later in 1990, Arundhathi presented some results on peak sets for real uniform function algebras on . In this paper, while we present a brief account of the work of others, we extend some of their results, either to real subspaces of or to real Banach function algebras on .

  19. The effect of welding speed and molten metal peak temperature on ...

    African Journals Online (AJOL)

    The effect of welding speed and molten metal peak temperature on thermal history of an arch - welded steel plate by numerical methods. SM Adedayo. Abstract. No Abstract. Journal of Applied Science, Engineering and Technology Vol. 1(1) 2001: 1-16. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL ...

  20. Space geodetic techniques for global modeling of ionospheric peak parameters

    Science.gov (United States)

    Alizadeh, M. Mahdi; Schuh, Harald; Schmidt, Michael

    The rapid development of new technological systems for navigation, telecommunication, and space missions which transmit signals through the Earth’s upper atmosphere - the ionosphere - makes the necessity of precise, reliable and near real-time models of the ionospheric parameters more crucial. In the last decades space geodetic techniques have turned into a capable tool for measuring ionospheric parameters in terms of Total Electron Content (TEC) or the electron density. Among these systems, the current space geodetic techniques, such as Global Navigation Satellite Systems (GNSS), Low Earth Orbiting (LEO) satellites, satellite altimetry missions, and others have found several applications in a broad range of commercial and scientific fields. This paper aims at the development of a three-dimensional integrated model of the ionosphere, by using various space geodetic techniques and applying a combination procedure for computation of the global model of electron density. In order to model ionosphere in 3D, electron density is represented as a function of maximum electron density (NmF2), and its corresponding height (hmF2). NmF2 and hmF2 are then modeled in longitude, latitude, and height using two sets of spherical harmonic expansions with degree and order 15. To perform the estimation, GNSS input data are simulated in such a way that the true position of the satellites are detected and used, but the STEC values are obtained through a simulation procedure, using the IGS VTEC maps. After simulating the input data, the a priori values required for the estimation procedure are calculated using the IRI-2012 model and also by applying the ray-tracing technique. The estimated results are compared with F2-peak parameters derived from the IRI model to assess the least-square estimation procedure and moreover, to validate the developed maps, the results are compared with the raw F2-peak parameters derived from the Formosat-3/Cosmic data.

  1. Improving EEG signal peak detection using feature weight learning ...

    Indian Academy of Sciences (India)

    Asrul Adam

    Neural network with random weights (NNRW); feature weight learning (FWL); electroencephalogram (EEG); peak detection algorithm; pattern recognition; particle swarm optimization (PSO). 1. Introduction. The utilization of peak detection algorithms has emerged as a useful tool in several physiological signal applications,.

  2. PEAK TRACKING WITH A NEURAL NETWORK FOR SPECTRAL RECOGNITION

    NARCIS (Netherlands)

    COENEGRACHT, PMJ; METTING, HJ; VANLOO, EM; SNOEIJER, GJ; DOORNBOS, DA

    1993-01-01

    A peak tracking method based on a simulated feed-forward neural network with back-propagation is presented. The network uses the normalized UV spectra and peak areas measured in one chromatogram for peak recognition. It suffices to train the network with only one set of spectra recorded in one

  3. Assessing peak aerobic capacity in Dutch law enforcement officers.

    NARCIS (Netherlands)

    Wittink, H.; Takken, T.; Groot, J.F. de; Reneman, M.; Peters, R.; Vanhees, L.

    2015-01-01

    Objectives: To cross-validate the existing peak rate of oxygen consumption (VO2peak) prediction equations in Dutch law enforcement officers and to determine whether these prediction equations can be used to predict VO2peak for groups and in a single individual. A further objective was to report

  4. Assessing peak aerobic capacity in Dutch law enforcement officers

    NARCIS (Netherlands)

    Wittink, Harriet; Takken, Tim; de Groot, Janke; Reneman, Michiel; Peters, Roelof; Vanhees, Luc

    2015-01-01

    Objectives: To cross-validate the existing peak rate of oxygen consumption (VO2peak) prediction equations in Dutch law enforcement officers and to determine whether these prediction equations can be used to predict VO2peak for groups and in a single individual. A further objective was to report

  5. Determination of the upper limit of a peak area

    International Nuclear Information System (INIS)

    Helene, O.

    1990-03-01

    This paper reports the procedure to extract an upper limit of a peak area in a multichannel spectrum. This procedure takes into account the finite shape of the peak and the uncertanties in the background and in the expected position of the peak. (author) [pt

  6. Forward ramp and Twin Peaks - 3D

    Science.gov (United States)

    1997-01-01

    A lander petal and the forward ramp are featured in this image, taken by the Imager for Mars Pathfinder (IMP) on Sol 3. 3D glasses are necessary to identify surface detail. There are several prominent rocks, including Wedge at left; Shark, Half-Dome, and Pumpkin in the background; and Flat Top and Little Flat Top at center.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech). The Imager for Mars Pathfinder (IMP) was developed by the University of Arizona Lunar and Planetary Laboratory under contract to JPL. Peter Smith is the Principal Investigator.Click below to see the left and right views individually. [figure removed for brevity, see original site] Left [figure removed for brevity, see original site] Right

  7. Has Athletic Performance Reached its Peak?

    Science.gov (United States)

    Berthelot, Geoffroy; Sedeaud, Adrien; Marck, Adrien; Antero-Jacquemin, Juliana; Schipman, Julien; Saulière, Guillaume; Marc, Andy; Desgorces, François-Denis; Toussaint, Jean-François

    2015-09-01

    Limits to athletic performance have long been a topic of myth and debate. However, sport performance appears to have reached a state of stagnation in recent years, suggesting that the physical capabilities of humans and other athletic species, such as greyhounds and thoroughbreds, cannot progress indefinitely. Although the ultimate capabilities may be predictable, the exact path for the absolute maximal performance values remains difficult to assess and relies on technical innovations, sport regulation, and other parameters that depend on current societal and economic conditions. The aim of this literature review was to assess the possible plateau of top physical capabilities in various events and detail the historical backgrounds and sociocultural, anthropometrical, and physiological factors influencing the progress and regression of athletic performance. Time series of performances in Olympic disciplines, such as track and field and swimming events, from 1896 to 2012 reveal a major decrease in performance development. Such a saturation effect is simultaneous in greyhound, thoroughbred, and frog performances. The genetic condition, exhaustion of phenotypic pools, economic context, and the depletion of optimal morphological traits contribute to the observed limitation of physical capabilities. Present conditions prevailing, we approach absolute physical limits and endure a continued period of world record scarcity. Optional scenarios for further improvements will mostly depend on sport technology and modification competition rules.

  8. The Technology Acceptance Model for Resource-Limited Settings (TAM-RLS): A Novel Framework for Mobile Health Interventions Targeted to Low-Literacy End-Users in Resource-Limited Settings.

    Science.gov (United States)

    Campbell, Jeffrey I; Aturinda, Isaac; Mwesigwa, Evans; Burns, Bridget; Santorino, Data; Haberer, Jessica E; Bangsberg, David R; Holden, Richard J; Ware, Norma C; Siedner, Mark J

    2017-11-01

    Although mobile health (mHealth) technologies have shown promise in improving clinical care in resource-limited settings (RLS), they are infrequently brought to scale. One limitation to the success of many mHealth interventions is inattention to end-user acceptability, which is an important predictor of technology adoption. We conducted in-depth interviews with 43 people living with HIV in rural Uganda who had participated in a clinical trial of a short messaging system (SMS)-based intervention designed to prompt return to clinic after an abnormal laboratory test. Interviews focused on established features of technology acceptance models, including perceived ease of use and perceived usefulness, and included open-ended questions to gain insight into unexplored issues related to the intervention's acceptability. We used conventional (inductive) and direct content analysis to derive categories describing use behaviors and acceptability. Interviews guided development of a proposed conceptual framework, the technology acceptance model for resource-limited settings (TAM-RLS). This framework incorporates both classic technology acceptance model categories as well as novel factors affecting use in this setting. Participants described how SMS message language, phone characteristics, and experience with similar technologies contributed to the system's ease of use. Perceived usefulness was shaped by the perception that the system led to augmented HIV care services and improved access to social support from family and colleagues. Emergent themes specifically related to mHealth acceptance among PLWH in Uganda included (1) the importance of confidentiality, disclosure, and stigma, and (2) the barriers and facilitators downstream from the intervention that impacted achievement of the system's target outcome. The TAM-RLS is a proposed model of mHealth technology acceptance based upon end-user experiences in rural Uganda. Although the proposed model requires validation, the TAM

  9. Peak detection method evaluation for ion mobility spectrometry by using machine learning approaches.

    Science.gov (United States)

    Hauschild, Anne-Christin; Kopczynski, Dominik; D'Addario, Marianna; Baumbach, Jörg Ingo; Rahmann, Sven; Baumbach, Jan

    2013-04-16

    Ion mobility spectrometry with pre-separation by multi-capillary columns (MCC/IMS) has become an established inexpensive, non-invasive bioanalytics technology for detecting volatile organic compounds (VOCs) with various metabolomics applications in medical research. To pave the way for this technology towards daily usage in medical practice, different steps still have to be taken. With respect to modern biomarker research, one of the most important tasks is the automatic classification of patient-specific data sets into different groups, healthy or not, for instance. Although sophisticated machine learning methods exist, an inevitable preprocessing step is reliable and robust peak detection without manual intervention. In this work we evaluate four state-of-the-art approaches for automated IMS-based peak detection: local maxima search, watershed transformation with IPHEx, region-merging with VisualNow, and peak model estimation (PME).We manually generated Metabolites 2013, 3 278 a gold standard with the aid of a domain expert (manual) and compare the performance of the four peak calling methods with respect to two distinct criteria. We first utilize established machine learning methods and systematically study their classification performance based on the four peak detectors' results. Second, we investigate the classification variance and robustness regarding perturbation and overfitting. Our main finding is that the power of the classification accuracy is almost equally good for all methods, the manually created gold standard as well as the four automatic peak finding methods. In addition, we note that all tools, manual and automatic, are similarly robust against perturbations. However, the classification performance is more robust against overfitting when using the PME as peak calling preprocessor. In summary, we conclude that all methods, though small differences exist, are largely reliable and enable a wide spectrum of real-world biomedical applications.

  10. Damage detection using sideband peak count in spectral correlation domain

    Science.gov (United States)

    Liu, Peipei; Sohn, Hoon

    2017-12-01

    Nonlinear ultrasonic techniques have been proven to be more sensitive to the presence of an early-stage damage than linear techniques. Among various nonlinear techniques, laser nonlinear wave modulation spectroscopy (LNWMS) utilizes a pulse laser to exert a broadband input and a damage on the target structure exhibits nonlinear wave modulation among various input frequency components. A sideband peak count (SPC) technique in the spectral frequency domain was proposed to estimate the damage-induced nonlinearity. In this study, the SPC operation is conducted in the spectral correlation domain so that noise has less influence on damage detection performance and a higher sensitivity to damage can be achieved. In addition, through spatial comparison of SPC over an inspection area, damage can be detected without relying on the baseline data obtained from a pristine condition. The performance of the proposed technique is validated using a numerical simulation performed on an aluminum plate with a simulated crack, and experiments performed on an aluminum plate with a fatigue crack and a carbon fiber reinforced polymer plate with delamination.

  11. Residential implementation of critical-peak pricing ofelectricity

    Energy Technology Data Exchange (ETDEWEB)

    Herter, Karen

    2006-06-29

    This paper investigates how critical-peak pricing (CPP)affects households with different usage and income levels, with the goalof informing policy makers who are considering the implementation of CPPtariffs in the residential sector. Using a subset of data from theCalifornia Statewide Pricing Pilot of 2003-2004, average load changeduring summer events, annual percent bill change, and post-experimentsatisfaction ratings are calculated across six customer segments,categorized by historical usage and income levels. Findings show thathigh-use customers respond significantly more in kW reduction than dolow-use customers, while low-use customers save significantly more inpercentage reduction of annual electricity bills than do high-usecustomers results that challenge the strategy of targeting only high-usecustomers for CPP tariffs. Across income levels, average load and billchanges were statistically indistinguishable, as were satisfaction ratesresults that are compatible with a strategy of full-scale implementationof CPP rates in the residential sector. Finally, the high-use customersearning less than $50,000 annually were the most likely of the groups tosee bill increases about 5 percent saw bill increases of 10 percent ormore suggesting that any residential CPP implementation might considertargeting this customer group for increased energy efficiencyefforts.

  12. A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments

    Directory of Open Access Journals (Sweden)

    McConville Malcolm J

    2007-10-01

    Full Text Available Abstract Background Gas chromatography-mass spectrometry (GC-MS is a robust platform for the profiling of certain classes of small molecules in biological samples. When multiple samples are profiled, including replicates of the same sample and/or different sample states, one needs to account for retention time drifts between experiments. This can be achieved either by the alignment of chromatographic profiles prior to peak detection, or by matching signal peaks after they have been extracted from chromatogram data matrices. Automated retention time correction is particularly important in non-targeted profiling studies. Results A new approach for matching signal peaks based on dynamic programming is presented. The proposed approach relies on both peak retention times and mass spectra. The alignment of more than two peak lists involves three steps: (1 all possible pairs of peak lists are aligned, and similarity of each pair of peak lists is estimated; (2 the guide tree is built based on the similarity between the peak lists; (3 peak lists are progressively aligned starting with the two most similar peak lists, following the guide tree until all peak lists are exhausted. When two or more experiments are performed on different sample states and each consisting of multiple replicates, peak lists within each set of replicate experiments are aligned first (within-state alignment, and subsequently the resulting alignments are aligned themselves (between-state alignment. When more than two sets of replicate experiments are present, the between-state alignment also employs the guide tree. We demonstrate the usefulness of this approach on GC-MS metabolic profiling experiments acquired on wild-type and mutant Leishmania mexicana parasites. Conclusion We propose a progressive method to match signal peaks across multiple GC-MS experiments based on dynamic programming. A sensitive peak similarity function is proposed to balance peak retention time and peak

  13. Automatic Peak Selection by a Benjamini-Hochberg-Based Algorithm

    KAUST Repository

    Abbas, Ahmed

    2013-01-07

    A common issue in bioinformatics is that computational methods often generate a large number of predictions sorted according to certain confidence scores. A key problem is then determining how many predictions must be selected to include most of the true predictions while maintaining reasonably high precision. In nuclear magnetic resonance (NMR)-based protein structure determination, for instance, computational peak picking methods are becoming more and more common, although expert-knowledge remains the method of choice to determine how many peaks among thousands of candidate peaks should be taken into consideration to capture the true peaks. Here, we propose a Benjamini-Hochberg (B-H)-based approach that automatically selects the number of peaks. We formulate the peak selection problem as a multiple testing problem. Given a candidate peak list sorted by either volumes or intensities, we first convert the peaks into p-values and then apply the B-H-based algorithm to automatically select the number of peaks. The proposed approach is tested on the state-of-the-art peak picking methods, including WaVPeak [1] and PICKY [2]. Compared with the traditional fixed number-based approach, our approach returns significantly more true peaks. For instance, by combining WaVPeak or PICKY with the proposed method, the missing peak rates are on average reduced by 20% and 26%, respectively, in a benchmark set of 32 spectra extracted from eight proteins. The consensus of the B-H-selected peaks from both WaVPeak and PICKY achieves 88% recall and 83% precision, which significantly outperforms each individual method and the consensus method without using the B-H algorithm. The proposed method can be used as a standard procedure for any peak picking method and straightforwardly applied to some other prediction selection problems in bioinformatics. The source code, documentation and example data of the proposed method is available at http://sfb.kaust.edu.sa/pages/software.aspx. © 2013

  14. ERP software vendors are targeting SMEs with SaaS and SOA offerings – Are these technologies beneficial to SMEs in Singapore when considering adopting ERP?

    OpenAIRE

    Lee, Pei Yin Karen

    2010-01-01

    Many articles that I have researched through the Internet have reflected an optimistic outlook into the Enterprise Resource Planning (ERP)software market despite the economic recession from late 2007 to current. The optimistic forecast was fuelled by globalization, midmarket growth and other factors. It is also due to the new Information Technology (IT) concepts that ERP software companies are adopting to entice midmarket enterprises worldwide to buy their services and products. My repor...

  15. Particle in cell simulation of peaking switch for breakdown evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Umbarkar, Sachin B.; Bindu, S.; Mangalvedekar, H.A.; Saxena, A.; Singh, N.M., E-mail: sachin.b.umbarkar@gmail.com [Department of Electric Engineering, Veermata Jijabai Technological Institute, Mumbai (India); Sharma, Archana; Saroj, P.C.; Mittal, K.C. [Accelerator Pulse Power Division, Bhabha Atomic Research Centre, Mumbai (India)

    2014-07-01

    Marx generator connected to peaking capacitor and peaking switch can generate Ultra-Wideband (UWB) radiation. A new peaking switch is designed for converting the existing nanosecond Marx generator to a UWB source. The paper explains the particle in cell (PIC) simulation for this peaking switch, using MAGIC 3D software. This peaking switch electrode is made up of copper tungsten material and is fixed inside the hermitically sealed derlin material. The switch can withstand a gas pressure up to 13.5 kg/cm{sup 2}. The lower electrode of the switch is connected to the last stage of the Marx generator. Initially Marx generator (without peaking stage) in air; gives the output pulse with peak amplitude of 113.75 kV and pulse rise time of 25 ns. Thus, we design a new peaking switch to improve the rise time of output pulse and to pressurize this peaking switch separately (i.e. Marx and peaking switch is at different pressure). The PIC simulation gives the particle charge density, current density, E counter plot, emitted electron current, and particle energy along the axis of gap between electrodes. The charge injection and electric field dependence on ionic dissociation phenomenon are briefly analyzed using this simulation. The model is simulated with different gases (N{sub 2}, H{sub 2}, and Air) under different pressure (2 kg/cm{sup 2}, 5 kg/cm{sup 2}, 10 kg/cm{sup 2}). (author)

  16. QRS peak detection for heart rate monitoring on Android smartphone

    Science.gov (United States)

    Pambudi Utomo, Trio; Nuryani, Nuryani; Darmanto

    2017-11-01

    In this study, Android smartphone is used for heart rate monitoring and displaying electrocardiogram (ECG) graph. Heart rate determination is based on QRS peak detection. Two methods are studied to detect the QRS complex peak; they are Peak Threshold and Peak Filter. The acquisition of ECG data is utilized by AD8232 module from Analog Devices, three electrodes, and Microcontroller Arduino UNO R3. To record the ECG data from a patient, three electrodes are attached to particular body’s surface of a patient. Patient’s heart activity which is recorded by AD8232 module is decoded by Arduino UNO R3 into analog data. Then, the analog data is converted into a voltage value (mV) and is processed to get the QRS complex peak. Heart rate value is calculated by Microcontroller Arduino UNO R3 uses the QRS complex peak. Voltage, heart rate, and the QRS complex peak are sent to Android smartphone by Bluetooth HC-05. ECG data is displayed as the graph by Android smartphone. To evaluate the performance of QRS complex peak detection method, three parameters are used; they are positive predictive, accuracy and sensitivity. Positive predictive, accuracy, and sensitivity of Peak Threshold method is 92.39%, 70.30%, 74.62% and for Peak Filter method are 98.38%, 82.47%, 83.61%, respectively.

  17. Reference Values for Peak Exercise Cardiac Output in Healthy Individuals.

    Science.gov (United States)

    Agostoni, Piergiuseppe; Vignati, Carlo; Gentile, Piero; Boiti, Costanza; Farina, Stefania; Salvioni, Elisabetta; Mapelli, Massimo; Magrì, Damiano; Paolillo, Stefania; Corrieri, Nicoletta; Sinagra, Gianfranco; Cattadori, Gaia

    2017-06-01

    Cardiac output (Q˙) is a key parameter in the assessment of cardiac function, its measurement being crucial for the diagnosis, treatment, and prognostic evaluation of all heart diseases. Until recently, Q˙ determination at peak exercise has been possible through invasive methods, so that normal values were obtained in studies based on small populations. Nowadays, peak Q˙ can be measured noninvasively by means of the inert gas rebreathing (IGR) technique. The present study was undertaken to provide reference values for peak Q˙ in the normal general population and to obtain a formula able to estimate peak exercise Q˙ from measured peak oxygen uptake (V˙o 2 ). We studied 500 normal subjects (age, 44.9 ± 1.5 years; range, 18-77 years; 260 men, 240 women) who underwent a maximal cardiopulmonary exercise test with peak Q˙ measurement by IGR. In the overall study sample, peak Q˙ was 13.2 ± 3.5 L/min (men, 15.3 ± 3.3 L/min; women, 11.0 ± 2.0 L/min; P exercise was (4.4 × peak V˙o 2 ) + 4.3 in the overall study cohort, (4.3 × peak V˙o 2 ) + 4.5 in men, and (4.9 × peak V˙o 2 ) + 3.6 in women. The simultaneous measurement of Q˙ and V˙o 2 at peak exercise in a large sample of healthy subjects provided an equation to predict peak Q˙ from peak V˙o 2 values. Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

  18. Effect of cardiac function on aortic peak time and peak enhancement during coronary CT angiography

    International Nuclear Information System (INIS)

    Sakai, Shuji; Yabuuchi, Hidetake; Chishaki, Akiko; Okafuji, Takashi; Matsuo, Yoshio; Kamitani, Takeshi; Setoguchi, Taro; Honda, Hiroshi

    2010-01-01

    Purpose: To examine the manner in which cardiac function affects the magnitude and timing of aortic contrast enhancement during coronary CT angiography (CTA). Materials and methods: Twenty-nine patients (21 men, 8 women; mean age, 64.4 ± 13.4 years; mean weight, 59.4 ± 10.3 kg) underwent measurement of cardiac output within 2 weeks of coronary CTA. The cardiac output of each patient was measured by the thermodilution technique and the cardiac index was calculated from the body surface area. During coronary CTA, attenuation of the descending aorta was measured at the workstation every 3 s. The aortic peak time (APT) and aortic peak enhancement (APE) of each patient were calculated. Pearson's correlation coefficient analysis was used to investigate the relationships between the cardiac output or cardiac index and APT or APE. Furthermore, the relationship between patient factors or parameters on test bolus injection and APT or APE was also evaluated. Results: The range of cardiac output, cardiac index, APT, and APE was 1.55-10.46 L/min (mean: 4.77 ± 2.13), 1.11-5.30 L/(min-m 2 ) (mean: 3.28 ± 1.08), 25-51 s (mean: 38.3 ± 7.5), and 273.1-598.1 HU (mean: 390.4 ± 72.1), respectively. With an increase in the cardiac index, both APT (r = -0.698, p < 0.0001) and APE (r = -0.573, p = 0.0009) decreased. There were significant correlations between the patient body weight and APT and APE with the test bolus injection, and with APT and APE during coronary CTA. Conclusion: The APT and APE during coronary CTA are closely related to cardiac function.

  19. Evaluation of peak power prediction equations in male basketball players.

    Science.gov (United States)

    Duncan, Michael J; Lyons, Mark; Nevill, Alan M

    2008-07-01

    This study compared peak power estimated using 4 commonly used regression equations with actual peak power derived from force platform data in a group of adolescent basketball players. Twenty-five elite junior male basketball players (age, 16.5 +/- 0.5 years; mass, 74.2 +/- 11.8 kg; height, 181.8 +/- 8.1 cm) volunteered to participate in the study. Actual peak power was determined using a countermovement vertical jump on a force platform. Estimated peak power was determined using countermovement jump height and body mass. All 4 prediction equations were significantly related to actual peak power (all p jump prediction equations, 12% for the Canavan and Vescovi equation, and 6% for the Sayers countermovement jump equation. In all cases peak power was underestimated.

  20. Group Elevator Peak Scheduling Based on Robust Optimization Model

    OpenAIRE

    ZHANG, J.; ZONG, Q.

    2013-01-01

    Scheduling of Elevator Group Control System (EGCS) is a typical combinatorial optimization problem. Uncertain group scheduling under peak traffic flows has become a research focus and difficulty recently. RO (Robust Optimization) method is a novel and effective way to deal with uncertain scheduling problem. In this paper, a peak scheduling method based on RO model for multi-elevator system is proposed. The method is immune to the uncertainty of peak traffic flows, optimal scheduling is re...

  1. Neuroscience imaging enabled by new highly tunable and high peak power femtosecond lasers

    Science.gov (United States)

    Hakulinen, T.; Klein, J.

    2017-02-01

    Neuroscience applications benefit from recent developments in industrial femtosecond laser technology. New laser sources provide several megawatts of peak power at wavelength of 1040 nm, which enables simultaneous optogenetics photoactivation of tens or even hundreds of neurons using red shifted opsins. Another recent imaging trend is to move towards longer wavelengths, which would enable access to deeper layers of tissue due to lower scattering and lower absorption in the tissue. Femtosecond lasers pumping a non-collinear optical parametric amplifier (NOPA) enable the access to longer wavelengths with high peak powers. High peak powers of >10 MW at 1300 nm and 1700 nm allow effective 3-photon excitation of green and red shifted calcium indicators respectively and access to deeper, sub-cortex layers of the brain. Early results include in vivo detection of spontaneous activity in hippocampus within an intact mouse brain, where neurons express GCaMP6 activated in a 3-photon process at 1320 nm.

  2. Precise determination of the Bragg peak position of proton beams in liquid water

    International Nuclear Information System (INIS)

    Marouane, Abdelhak; Ouaskit, Said; Inchaouh, Jamal

    2011-01-01

    The influence of water molecules on the surrounding biological molecules during irradiation with protons is currently a major subject in radiation science. Proton collisions with the water molecules are estimated around the Bragg peak region, taking into account ionization, excitation, charge-changing processes, and energetic secondary electron behavior. The Bragg peak profile and position was determined by adopting a new approach involving discretization, incrementation, and dividing the target into layers, the thickness of each layer being selected randomly from a distribution weighted by the values of the total interaction cross section, from excitation up to ionization of the target and the incident projectile charge exchange. The calculation was carried out by a Monte-Carlo simulation in the energy range 20 ≤ E ≤ 10 8 eV, including the relativistic corrections.

  3. Nonlinear preprocessing method for detecting peaks from gas chromatograms

    Directory of Open Access Journals (Sweden)

    Min Hyeyoung

    2009-11-01

    Full Text Available Abstract Background The problem of locating valid peaks from data corrupted by noise frequently arises while analyzing experimental data. In various biological and chemical data analysis tasks, peak detection thus constitutes a critical preprocessing step that greatly affects downstream analysis and eventual quality of experiments. Many existing techniques require the users to adjust parameters by trial and error, which is error-prone, time-consuming and often leads to incorrect analysis results. Worse, conventional approaches tend to report an excessive number of false alarms by finding fictitious peaks generated by mere noise. Results We have designed a novel peak detection method that can significantly reduce parameter sensitivity, yet providing excellent peak detection performance and negligible false alarm rates from gas chromatographic data. The key feature of our new algorithm is the successive use of peak enhancement algorithms that are deliberately designed for a gradual improvement of peak detection quality. We tested our approach with real gas chromatograms as well as intentionally contaminated spectra that contain Gaussian or speckle-type noise. Conclusion Our results demonstrate that the proposed method can achieve near perfect peak detection performance while maintaining very small false alarm probabilities in case of gas chromatograms. Given the fact that biological signals appear in the form of peaks in various experimental data and that the propose method can easily be extended to such data, our approach will be a useful and robust tool that can help researchers highlight valid signals in their noisy measurements.

  4. Evaluation of peak-fitting software for gamma spectrum analysis

    International Nuclear Information System (INIS)

    Zahn, Guilherme S.; Genezini, Frederico A.; Moralles, Mauricio

    2009-01-01

    In all applications of gamma-ray spectroscopy, one of the most important and delicate parts of the data analysis is the fitting of the gamma-ray spectra, where information as the number of counts, the position of the centroid and the width, for instance, are associated with each peak of each spectrum. There's a huge choice of computer programs that perform this type of analysis, and the most commonly used in routine work are the ones that automatically locate and fit the peaks; this fit can be made in several different ways - the most common ways are to fit a Gaussian function to each peak or simply to integrate the area under the peak, but some software go far beyond and include several small corrections to the simple Gaussian peak function, in order to compensate for secondary effects. In this work several gamma-ray spectroscopy software are compared in the task of finding and fitting the gamma-ray peaks in spectra taken with standard sources of 137 Cs, 60 Co, 133 Ba and 152 Eu. The results show that all of the automatic software can be properly used in the task of finding and fitting peaks, with the exception of GammaVision; also, it was possible to verify that the automatic peak-fitting software did perform as well as - and sometimes even better than - a manual peak-fitting software. (author)

  5. Determination of kinetic energy release from metastable peak widths

    DEFF Research Database (Denmark)

    Petersen, Allan Christian; Sølling, Theis Ivan

    2017-01-01

    The kinetic energy that is released upon bond rupture is often represented as T1/2. A value that is derived from the FWHM of a fragment peak by the use of two different conversion formulas. The choice of formula depends on whether the peak is recorded by scanning a magnetic sector or an electrost......The kinetic energy that is released upon bond rupture is often represented as T1/2. A value that is derived from the FWHM of a fragment peak by the use of two different conversion formulas. The choice of formula depends on whether the peak is recorded by scanning a magnetic sector...

  6. Adherence to self-monitoring via interactive voice response technology in an eHealth intervention targeting weight gain prevention among Black women: randomized controlled trial.

    Science.gov (United States)

    Steinberg, Dori M; Levine, Erica L; Lane, Ilana; Askew, Sandy; Foley, Perry B; Puleo, Elaine; Bennett, Gary G

    2014-04-29

    eHealth interventions are effective for weight control and have the potential for broad reach. Little is known about the use of interactive voice response (IVR) technology for self-monitoring in weight control interventions, particularly among populations disproportionately affected by obesity. This analysis sought to examine patterns and predictors of IVR self-monitoring adherence and the association between adherence and weight change among low-income black women enrolled in a weight gain prevention intervention. The Shape Program was a randomized controlled trial comparing a 12-month eHealth behavioral weight gain prevention intervention to usual care among overweight and obese black women in the primary care setting. Intervention participants (n=91) used IVR technology to self-monitor behavior change goals (eg, no sugary drinks, 10,000 steps per day) via weekly IVR calls. Weight data were collected in clinic at baseline, 6, and 12 months. Self-monitoring data was stored in a study database and adherence was operationalized as the percent of weeks with a successful IVR call. Over 12 months, the average IVR completion rate was 71.6% (SD 28.1) and 52% (47/91) had an IVR completion rate ≥80%. At 12 months, IVR call completion was significantly correlated with weight loss (r =-.22; P=.04) and participants with an IVR completion rate ≥80% had significantly greater weight loss compared to those with an IVR completion rate self-monitoring. Adherence to IVR self-monitoring was high among socioeconomically disadvantaged black women enrolled in a weight gain prevention intervention. Higher adherence to IVR self-monitoring was also associated with greater weight change. IVR is an effective and useful tool to promote self-monitoring and has the potential for widespread use and long-term sustainability. Clinicaltrials.gov NCT00938535; http://www.clinicaltrials.gov/ct2/show/NCT00938535.

  7. Assessing peak aerobic capacity in Dutch law enforcement officers

    Directory of Open Access Journals (Sweden)

    Harriet Wittink

    2015-06-01

    Full Text Available Objectives: To cross-validate the existing peak rate of oxygen consumption (VO2peak prediction equations in Dutch law enforcement officers and to determine whether these prediction equations can be used to predict VO2peak for groups and in a single individual. A further objective was to report normative absolute and relative VO2peak values of a sample of law enforcement officers in the Netherlands. Material and Methods: The peak rate of oxygen consumption (ml×kg–1×min–1 was measured using a maximal incremental bicycle test in 1530 subjects, including 1068 male and 461 female police officers. Validity of the prediction equations for groups was assessed by comparing predicted VO2peak with measured VO2peak using paired t-tests. For individual differences limits of agreement (LoA were calculated. Equations were considered valid for individuals when the difference between measured and predicted VO2peak did not exceed ±1 metabolic equivalent (MET in 95% of individuals. Results: None of the equations met the validity criterion of 95% of individuals having ±1 MET difference or less than the measured value. Limits of agreement (LoAs were large in all predictions. At the individual level, none of the equations were valid predictors of VO2peak (ml×kg–1×min–1. Normative values for Dutch law enforcement officers were presented. Conclusions: Substantial differences between measured and predicted VO2peak (ml×kg–1×min–1 were found. Most tested equations were invalid predictors of VO2peak at group level and all were invalid at individual levels.

  8. Systems Modelling of the Socio-Technical Aspects of Residential Electricity Use and Network Peak Demand

    Science.gov (United States)

    Lewis, Jim; Mengersen, Kerrie; Buys, Laurie; Vine, Desley; Bell, John; Morris, Peter; Ledwich, Gerard

    2015-01-01

    locations and highlighted that household numbers, demographics as well as the different climates were significant factors. It presented possible network peak demand reductions which would delay any upgrade of networks, resulting in savings for Queensland utilities and ultimately for households. The use of this systems approach using Bayesian networks to assist the management of peak demand in different modelled locations in Queensland provided insights about the most important elements in the system and the intervention strategies that could be tailored to the targeted customer segments. PMID:26226511

  9. Systems Modelling of the Socio-Technical Aspects of Residential Electricity Use and Network Peak Demand.

    Science.gov (United States)

    Lewis, Jim; Mengersen, Kerrie; Buys, Laurie; Vine, Desley; Bell, John; Morris, Peter; Ledwich, Gerard

    2015-01-01

    and highlighted that household numbers, demographics as well as the different climates were significant factors. It presented possible network peak demand reductions which would delay any upgrade of networks, resulting in savings for Queensland utilities and ultimately for households. The use of this systems approach using Bayesian networks to assist the management of peak demand in different modelled locations in Queensland provided insights about the most important elements in the system and the intervention strategies that could be tailored to the targeted customer segments.

  10. Extreme daily increases in peak electricity demand: Tail-quantile estimation

    International Nuclear Information System (INIS)

    Sigauke, Caston; Verster, Andréhette; Chikobvu, Delson

    2013-01-01

    A Generalized Pareto Distribution (GPD) is used to model extreme daily increases in peak electricity demand. The model is fitted to years 2000–2011 recorded data for South Africa to make a comparative analysis with the Generalized Pareto-type (GP-type) distribution. Peak electricity demand is influenced by the tails of probability distributions as well as by means or averages. At times there is a need to depart from the average thinking and exploit information provided by the extremes (tails). Empirical results show that both the GP-type and the GPD are a good fit to the data. One of the main advantages of the GP-type is the estimation of only one parameter. Modelling of extreme daily increases in peak electricity demand helps in quantifying the amount of electricity which can be shifted from the grid to off peak periods. One of the policy implications derived from this study is the need for day-time use of electricity billing system similar to the one used in the cellular telephone/and fixed line-billing technology. This will result in the shifting of electricity demand on the grid to off peak time slots as users try to avoid high peak hour charges. - Highlights: ► Policy makers should design demand response strategies to save electricity. ► Peak electricity demand is influenced by tails of probability distributions. ► Both the GSP and the GPD are a good fit to the data. ► Accurate assessment of level and frequency of extreme load forecasts is important.

  11. Cadence, peak vertical acceleration, and peak loading rate during ambulatory activities: implications for activity prescription for bone health.

    Science.gov (United States)

    Rowlands, Alex V; Schuna, John M; Stiles, Victoria H; Tudor-Locke, Catrine

    2014-09-01

    Previous research has reported peak vertical acceleration and peak loading rate thresholds beneficial to bone mineral density (BMD). Such thresholds are difficult to translate into meaningful recommendations for physical activity. Cadence (steps/min) is a more readily interpretable measure of ambulatory activity. To examine relationships between cadence, peak vertical acceleration and peak loading rate during ambulation and identify the cadence associated with previously reported bone-beneficial thresholds for peak vertical acceleration (4.9 g) and peak loading rate (43 BW/s). Ten participants completed 8 trials each of: slow walking, brisk walking, slow running, and fast running. Acceleration data were captured using a GT3×+ accelerometer worn at the hip. Peak loading rate was collected via a force plate. Strong relationships were identified between cadence and peak vertical acceleration (r = .96, P acceleration and 43 BW/s peak loading rate thresholds, respectively. Cadences ≥ 2.0 to 2.6 steps/s equate to acceleration and loading rate thresholds related to bone health. Further research is needed to investigate whether the frequency of daily occurrences of this cadence is associated with BMD.

  12. Peak effect in surface resistance at microwave frequencies in Dy ...

    Indian Academy of Sciences (India)

    In the measurements at both frequencies the induced microwave current was always less than the critical current of the films. The reason for observation of this peak effect in these films has been explained in our earlier publication [5]. Comparing figures 1 and 2, it is observed that the peaks in sample S1 are broader and.

  13. Psychological Preparation for Peak Performance in Sports Competition

    Science.gov (United States)

    Ohuruogu, Ben; Jonathan, Ugwuanyi I.; Ikechukwu, Ugwu Jude

    2016-01-01

    This paper attempts to make an overview of various techniques, sport psychologist adopt in psychological preparation of athletes for peak performance. To attain peak performance in sports competitions, coaches and athletes should not base their prospect on physical training on sport skills alone rather should integrate both the mental and physical…

  14. Online junction temperature measurement using peak gate current

    DEFF Research Database (Denmark)

    Baker, Nick; Munk-Nielsen, Stig; Iannuzzo, Francesco

    2015-01-01

    A new method for junction temperature measurement of MOS-gated power semiconductor switches is presented. The measurement method involves detecting the peak voltage over the external gate resistor of an IGBT or MOSFET during turn-on. This voltage is directly proportional to the peak gate current...

  15. Flood Peak Estimation Using Rainfall Run off Models | Matondo ...

    African Journals Online (AJOL)

    The design of hydraulic structures such as road culverts, road bridges and dam spillways requires the determination of the design food peak. Two approaches are available in the determination of the design flood peak and these are: flood frequency analysis and rainfall runoff models. Flood frequency analysis requires a ...

  16. Probabilistic Analysis of Peak Daily Rainfall for Prediction purposes ...

    African Journals Online (AJOL)

    The obtained peak daily rainfall values were subjected to Gumbel, Log-Gumbel, Normal, Log-Normal, Pearson and Log-Pearson probability distributions. Mathematical equation for probability distribution functions were established for each town and used to predict peak rainfall. The predicted values were subjected to ...

  17. Peak Expiratory Flow Rate In Cigarette Smokers | Ukoli | Highland ...

    African Journals Online (AJOL)

    Objective: To compare lung function between smokers and non-smokers using Peak Expiratory Flow Rate (PEFR). Methods: This study examines the peak expiratory flow rate (PEFR) of three hundred and forty cigarette smokers, age and sex-matched with PEFR of equal number of non-smokers. Results: The mean PEFR of ...

  18. Diffraction peaks in x-ray spectroscopy: Friend or foe?

    International Nuclear Information System (INIS)

    Tissot, R.G.; Goehner, R.P.

    1992-01-01

    Diffraction peaks can occur as unidentifiable peaks in the energy spectrum of an x-ray spectrometric analysis. Recently, there has been increased interest in oriented polycrystalline films and epitaxial films on single crystal substrates for electronic applications. Since these materials diffract x-rays more efficiently than randomly oriented polycrystalline materials, diffraction peaks are being observed more frequently in x-ray fluorescent spectra. In addition, micro x-ray spectrometric analysis utilizes a small, intense, collimated x-ray beam that can yield well defined diffraction peaks. In some cases these diffraction peaks can occur at the same position as elemental peaks. These diffraction peaks, although a possible problem in qualitative and quantitative elemental analysis, can give very useful information about the crystallographic structure and orientation of the material being analyzed. The observed diffraction peaks are dependent on the geometry of the x-ray spectrometer, the degree of collimation and the distribution of wavelengths (energies) originating from the x-ray tube and striking the sample

  19. Quality Assurance in the Determination of Overlapping Peak Areas

    DEFF Research Database (Denmark)

    Christensen, L.H.; Heydorn, K.

    1987-01-01

    The ability of different computer programs to yield accurate peak areas in statistical control in the case of partially overlapping photopeaks has been tested by the Analysis of Precision. A modified Covell method, two commercially available peak-fitting programs from Nuclear Data and Ortec, and ...

  20. Limitations of middle cerebral artery peak systolic velocity in the ...

    African Journals Online (AJOL)

    We present a case of a mother with severe pre-eclampsia at 32 weeks' gestation and non-immune fetal hydrops without obvious cause. Since the. MCA peak systolic velocity (PSV) was ... Limitations of middle cerebral artery peak systolic velocity .... [7] found MCA PSV of value in 9 women with chronic abruption, but in 5.

  1. Single-peak solitary wave solutions for the variant Boussinesq ...

    Indian Academy of Sciences (India)

    ∈ H1 loc(R). (iii) Similar to the proof of the above (ii),we omit it here. This completes the proof. 3. Smooth and cusped single-peak solitary wave solutions. Theorem 2.4 gives a classification for all single-peak solitary wave solutions for eq. (2.4).

  2. Identification of peaks in multidimensional coincidence {gamma}-ray spectra

    Energy Technology Data Exchange (ETDEWEB)

    Morhac, Miroslav E-mail: fyzimiro@savba.sk; Kliman, Jan; Matousek, Vladislav; Veselsky, Martin; Turzo, Ivan

    2000-03-21

    In the paper a new algorithm to find peaks in two, three and multidimensional spectra, measured in large multidetector {gamma}-ray arrays, is derived. Given the dimension m, the algorithm is selective to m-fold coincidence peaks. It is insensitive to intersections of lower-fold coincidences, hereinafter called ridges.

  3. quasi hyperrigidity and weak peak points for non-commutative ...

    Indian Academy of Sciences (India)

    7

    The concepts of peak point and Choquet boundary play an important role in several areas of classical ... theory studied extensively with the concept of Korovkin (hyperrigid sets) sets. The idea of peak points was .... An operator system S in a C∗-algebra A is a self-adjoint linear subspace of A containing the iden- tity of A ...

  4. Determination of gaussian peaks in gamma spectra by iterative regression

    International Nuclear Information System (INIS)

    Nordemann, D.J.R.

    1987-05-01

    The parameters of the peaks in gamma-ray spectra are determined by a simple iterative regression method. For each peak, the parameters are associated with a gaussian curve (3 parameters) located above a linear continuum (2 parameters). This method may produces the complete result of the calculation of statistical uncertainties and an accuracy higher than others methods. (author) [pt

  5. Daily Nigerian peak load forecasting using artificial neural network ...

    African Journals Online (AJOL)

    A daily peak load forecasting technique that uses artificial neural network with seasonal indices is presented in this paper. A neural network of relatively smaller size than the main prediction network is used to predict the daily peak load for a period of one year over which the actual daily load data are available using one ...

  6. Mazama and Glacier Peak Volcanic Ash Layers: Relative Ages.

    Science.gov (United States)

    Fryxell, R

    1965-03-12

    Physiographic and stratigraphic evidence supports the regional correlation of two volcanic ash layers with extinct Mount Mazama at Crater Lake, Oregon, and Glacier Peak in the northern Cascade Range of Washington. A radiocarbon age of 12,000 +/- 310 years confirms geological evidence that ash derived from the Glacier Peak eruption is substantially older than ash from the Mazama eruption of 6600 years ago.

  7. SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells.

    Science.gov (United States)

    Hussain, Ahmad Fawzi; Kampmeier, Florian; von Felbert, Verena; Merk, Hans-F; Tur, Mehmet Kemal; Barth, Stefan

    2011-12-21

    Cancer cells can be killed by photosensitizing agents that induce toxic effects when exposed to nonhazardous light, but this also causes significant damage to surrounding healthy cells. The specificity of photodynamic therapy can be increased by conjugating photosensitizing agents to antibodies and antibody fragments that bind specifically to tumor cell antigens. However, standard conjugation reactions produce heterogeneous products whose targeting specificity and spectroscopic properties can be compromised. In this study, we used an antibody fragment (scFv-425) that binds to the epidermal growth factor receptor (EGFR) as a model to investigate the use of SNAP-tag fusions as an improved conjugation strategy. The scFv-425-SNAP-tag fusion protein allowed the specific conjugation of a chlorin e6 photosensitizer modified with O(6)-benzylguanine, generating a homogeneous product that was delivered specifically to EGFR(+) cancer cells and resulted in significant, tumor cell-specific cytotoxicity. The impact of our results on the development of photodynamic therapy is discussed.

  8. Study Protocol of MINI SALTEN: a technology-based multi-component intervention in the school environment targeting healthy habits of first grade children and their parents.

    Science.gov (United States)

    Kovalskys, Irina; Rausch Herscovici, Cecile; Indart Rougier, Paula; De Gregorio, María José; Zonis, Luciana; Orellana, Liliana

    2017-05-06

    MINI SALTEN is a program developed to increase moderate to vigorous physical activity (PA) and improve eating habits at home and school in first grade children. It aims to assess the effects of a technology family-based and PA school-based intervention. The purpose of this manuscript is to describe the protocol design and the MINISALTEN intervention. This is cluster-randomized controlled trial designed to run from July 2015 to November 2016 in 12 public schools of the city of Buenos Aires, matched for socio-demographic characteristics. The intervention is based on two main components: (a) "active breaks" (AB): implemented during school breaks by a PA instructor; (b) "virtual" (V): web-based contents delivered to the families via a multiplatform application. Using a computer generated random sequence participants are allocated to one of four intervention conditions: (AB), (V), (AB + V), and control (C). Outcomes are measured at baseline and 12 months post intervention, and will include data collected from the child and her/his mother/father or guardian. Primary outcome measures are: PA and sedentary behaviour (measured with accelerometers). Secondary outcome measures related are: percentage of kilocalories (kcal) from added sugars, and from total and saturated fats; grams of fruits and vegetables; and number of snacks and kcal coming from their added sugars and total and saturated fats. Family socio-economic level, home environment, and school environment will also be assessed. Statistical analysis is on an intention-to-treat principle. Baseline characteristics are described using summary measures and mixed models (with school as random effect). The effect of the two interventions will be estimated using a generalized mixed linear model with link and distribution selected according to the type of outcome. Included random effects are: child (or mother/father or guardian) accounting for repeated measures; school accounting for cluster induced by school. The most

  9. Reliability of peak treadmill exercise tests in mild Alzheimer disease.

    Science.gov (United States)

    Anderson, Heather S; Kluding, Patricia M; Gajewski, Byron J; Donnelly, Joseph E; Burns, Jeffrey M

    2011-08-01

    The purpose of this study was to determine the reliability of treadmill peak exercise testing in people with very mild-to-mild Alzheimer disease (AD). Sixteen subjects with very mild-to-mild AD performed graded peak treadmill exercise tests twice within a 14-day period. Heart rate, oxygen consumption, and respiratory exchange ratio (RER) were continuously monitored. Peak values were analyzed for absolute level of agreement. Fourteen participants (87.5%) completed testing. Reliability was excellent with total peak oxygen consumption (VO2peak) (ml/kg/min) highly correlated across the two tests (r = 0.94, p exercise testing on a treadmill is reliable in the early stages of AD.

  10. Diffraction peak shift in MgO small crystallites

    Science.gov (United States)

    Gielen, P.

    1998-08-01

    A linear relationship is found between peak position and peak width for the X-ray diffraction peaks of MgO very small crystallites. The sign of the peak shift is explained. The peak shape is asymmetrical, the more asymmetrical the broader it is. The second Heisenberg's uncertainty relation is reinterpreted. L'auteur trouve une relation linéaire entre la position des pics et la largeur des pics de diffraction des rayons X pour de très petites cristallites de MgO. Il explique le signe du déplacement des pics. La forme des pics est asymétrique, d'autant plus asymétrique qu'ils sont plus larges. La seconde relation d'incertitude de Heisenberg est réinterprétée.

  11. Experiences of Vulnerable Residential Customer Subpopulations with Critical Peak Pricing

    Energy Technology Data Exchange (ETDEWEB)

    Cappers, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Spurlock, C. Anna [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Todd, Annika [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Jin, Ling [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-04-13

    DOE decided to co-fund ten utilities to undertake eleven experimentally-designed Consumer Behavior Studies (CBS) that proposed to examine a wide range of the topics of interest to the electric utility industry. Each chosen utility was to design, implement and evaluate their own study in order to address questions of interest both to itself and to its applicable regulatory authority, whose approval was generally necessary for the study to proceed. The DOE Office of Energy Delivery and Electricity Reliability (OE), however, did set guidelines, both in the FOA and subsequently during the contracting period, for what would constitute an acceptable study under the Grant. To assist in ensuring these guidelines were adhered to, OE requested that LBNL act as project manager for these Consumer Behavior Studies to achieve consistency of experimental design and adherence to data collection and reporting protocols across the ten utilities. As part of its role, LBNL formed technical advisory groups (TAG) to separately assist each of the utilities by providing technical assistance in all aspects of the design, implementation and evaluation of their studies. LBNL was also given a unique opportunity to perform a comprehensive, cross-study analysis that uses the customer-level interval meter and demographic data made available by these utilities due to SGIG-imposed reporting requirements, in order to analyze critical policy issues associated with AMI-enabled rates and control/information technology. LBNL will publish the results of these analyses in a series of research reports, of which this is one, that attempt to address critical policy issues relating to a variety of topics including customer acceptance, retention and load response to time-based rates and various forms of enabling control and information technologies. This report extends the existing empirical literature on the experiences of low-income customers exposed to critical peak pricing, and provides the first glimpses

  12. The effect of utility time-varying pricing and load control strategies on residential summer peak electricity use. A review

    International Nuclear Information System (INIS)

    Newsham, Guy R.; Bowker, Brent G.

    2010-01-01

    Peak demand for electricity in North America is expected to grow, challenging electrical utilities to supply this demand in a cost-effective, reliable manner. Therefore, there is growing interest in strategies to reduce peak demand by eliminating electricity use, or shifting it to non-peak times. This strategy is commonly called 'demand response'. In households, common strategies are time-varying pricing, which charge more for energy use on peak, or direct load control, which allows utilities to curtail certain loads during high demand periods. We reviewed recent North American studies of these strategies. The data suggest that the most effective strategy is a critical peak price (CPP) program with enabling technology to automatically curtail loads on event days. There is little evidence that this causes substantial hardship for occupants, particularly if they have input into which loads are controlled and how, and have an override option. In such cases, a peak load reduction of at least 30% is a reasonable expectation. It might be possible to attain such load reductions without enabling technology by focusing on household types more likely to respond, and providing them with excellent support. A simple time-of-use (TOU) program can only expect to realise on-peak reductions of 5%. (author)

  13. Neutron capture therapy (NCT) and in-hospital neutron irradiator (IHNI) a new technology on binary targeting radiation therapy of cancer

    International Nuclear Information System (INIS)

    Zhou Yongmao

    2009-01-01

    BNCT is finally becoming 'a new option against cancer'. The difficulties for its development progress of that firstly is to improve the performance of boron compounds,secondly, it is the requirements of quantification and accuracy upon radiation dosimetry evaluation in clinical trials. Furthermore, that is long anticipation on hospital base neutron sources. It includes dedicated new NCT reactor, accelerator based neutron sources, and isotope source facilities. In addition to reactors, so far, the technology of other types of sources for clinical trials is not yet completely proven. The In-Hospital Neutron Irradiator specially designed for NCT, based on the MNSR successfully developed by China, can be installed inside or near the hospital and operated directly by doctors. The Irradiator has two neutron beams for respective treatment of the shallow and deep tumors. It is expected to initiate operation in the end of this year. It would provide a safe, low cost, and effective treatment tool for the NCT routine application in near future. (authors)

  14. Depending on scientific and technological progress to prospect for superlarge uranium deposits. Across-century target for uranium resources exploration work in China

    International Nuclear Information System (INIS)

    Shen Feng

    1995-01-01

    After over 30 years' development, uranium resources exploration work in China has resulted in the discovery of more than 10 economic types of uranium deposits in 23 provinces (regions) of the whole country and large quantities of uranium reserves have been submitted which guarantee the development of nuclear industry in China. However, characteristics such as smaller size of deposits and ore bodies, and lower ore grade of discovered China's uranium deposits have brought about a series of problems on how to economically exploit and utilize these uranium resources. To prospect for superlarge uranium deposits is a guarantee of making uranium resources essentially meet the demand for the long-term development of nuclear industry in China, and is an important way of improving economic benefits in mining China's uranium resources. It is an important mark for uranium geological exploration work to go up a new step as well. China exhibits the geological environment in which various types of superlarge uranium deposits can be formed. Having the financial support from the state to uranium resources exploration work, having professional uranium exploration teams well-experienced in ore prospecting, having modernized uranium exploration techniques and equipment and also having foreign experience in prospecting for superlarge uranium deposits as reference, it is entirely possible to find out superlarge uranium deposits in China at the end of this century and at the beginning of next century. In order to realize the objective, the most important prerequisite is that research work on metallogenetic geological theory and exploration techniques and prospecting methodology for superlarge uranium deposits must be strengthened, and technical quality of the geological teams must be improved. Within this century, prospect targets should be selected and located accurately to carry out the emphatic breakthrough in exploration strategy

  15. Targeted intraoperative radiotherapy in oncology

    CERN Document Server

    Keshtgar, Mohammed; Wenz, Frederik

    2014-01-01

    Targeted intraoperative radiotherapy is a major advance in the management of cancer patients. With an emphasis on practical aspects, this book offers an ideal introduction to this innovative  technology for clinicians.

  16. Peak broadening in paper chromatography and related techniques : III. Peak broadening in thin-layer chromatography on cellulose powder

    NARCIS (Netherlands)

    Ligny, C.L. de; Remijnse, A.G.

    1968-01-01

    The mechanism of peak broadening in thin-layer chromatography on cellulose powder was investigated by comparing the peak widths obtained in chromatography with those caused only by diffusion in the cellulose powder, for a set of amino acids of widely differing RF values and six kinds of cellulose

  17. Antiproton Target

    CERN Multimedia

    1980-01-01

    Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

  18. Dual Peak Cholera transmission in South Asia: A Hydroclimatological Explanation

    Science.gov (United States)

    Akanda, A. S.; Jutla, A.; Islam, S.

    2009-04-01

    Cholera has reemerged as a global killer with the world witnessing an unprecedented rise in cholera infection and transmission since the 1990s. Cholera outbreaks across most affected areas show infection patterns with a single annual peak. However, cholera incidences in the Bengal Delta region, the native homeland of cholera, show bi-annual peaks. The mechanisms behind this unique seasonal dual peak phenomenon in cholera dynamics, especially the role of climatic and hydrologic variables, are not fully understood. We disaggregate regional streamflow and sea surface temperature data into seasonal components, and analyze their correlation with the two seasonal peaks in Bangladesh cholera incidence records. Low flow in the Brahmaputra and the Ganges during spring is associated with inward plankton transport from the ocean and the first cholera outbreaks of the year. Peak streamflow of these rivers, on the other hand, create a different cholera transmission environment; peak flood volumes and extent of flood-affected areas during monsoon are responsible for widespread water contamination and subsequent cholera outbreaks. Our preliminary results demonstrate that the seasonality and dual peaks of cholera transmission in this region may be explained by two distinctly different hydroclimatological drivers. We will quantify the roles of these processes and explain the nature of these drivers.

  19. Modeled future peak streamflows in four coastal Maine rivers

    Science.gov (United States)

    Hodgkins, Glenn A.; Dudley, Robert W.

    2013-01-01

    To safely and economically design bridges and culverts, it is necessary to compute the magnitude of peak streamflows that have specified annual exceedance probabilities (AEPs). Annual precipitation and air temperature in the northeastern United States are, in general, projected to increase during the 21st century. It is therefore important for engineers and resource managers to understand how peak flows may change in the future. This report, prepared in cooperation with the Maine Department of Transportation (MaineDOT), presents modeled changes in peak flows at four basins in coastal Maine on the basis of projected changes in air temperature and precipitation. To estimate future peak streamflows at the four basins in this study, historical values for climate (temperature and precipitation) in the basins were adjusted by different amounts and input to a hydrologic model of each study basin. To encompass the projected changes in climate in coastal Maine by the end of the 21st century, air temperatures were adjusted by four different amounts, from -3.6 degrees Fahrenheit (ºF) (-2 degrees Celsius (ºC)) to +10.8 ºF (+6 ºC) of observed temperatures. Precipitation was adjusted by three different percentage values from -15 percent to +30 percent of observed precipitation. The resulting 20 combinations of temperature and precipitation changes (includes the no-change scenarios) were input to Precipitation-Runoff Modeling System (PRMS) watershed models, and annual daily maximum peak flows were calculated for each combination. Modeled peak flows from the adjusted changes in temperature and precipitation were compared to unadjusted (historical) modeled peak flows. Annual daily maximum peak flows increase or decrease, depending on whether temperature or precipitation is adjusted; increases in air temperature (with no change in precipitation) lead to decreases in peak flows, whereas increases in precipitation (with no change in temperature) lead to increases in peak flows. As

  20. System dynamics model of Hubbert Peak for China's oil

    International Nuclear Information System (INIS)

    Tao Zaipu; Li Mingyu

    2007-01-01

    American geophysicist M. King Hubbert in 1956 first introduced a logistic equation to estimate the peak and lifetime production for oil of USA. Since then, a fierce debate ensued on the so-called Hubbert Peak, including also its methodology. This paper proposes to use the generic STELLA model to simulate Hubbert Peak, particularly for the Chinese oil production. This model is demonstrated as being robust. We used three scenarios to estimate the Chinese oil peak: according to scenario 1 of this model, the Hubbert Peak for China's crude oil production appears to be in 2019 with a value of 199.5 million tonnes, which is about 1.1 times the 2005 output. Before the peak comes, Chinese oil output will grow by about 1-2% annually, after the peak, however, the output will fall. By 2040, the annual production of Chinese crude oil would be equivalent to the level of 1990. During the coming 20 years, the crude oil demand of China will probably grow at the rate of 2-3% annually, and the gap between domestic supply and total demand may be more than half of this demand

  1. Two density peaks in low magnetic field helicon plasma

    Science.gov (United States)

    Wang, Y.; Zhao, G.; Liu, Z. W.; Ouyang, J. T.; Chen, Q.

    2015-09-01

    In this paper, we report two density peaks in argon helicon plasma under an axial magnetic field from 0 G to 250 G with Boswell-type antenna driven by radio frequency (RF) power of 13.56 MHz. The first peak locates at 40-55 G and the second one at 110-165 G, as the RF power is sustainably increased from 100 W to 250 W at Ar pressure of 0.35 Pa. The absorbed power of two peaks shows a linear relationship with the magnetic field. End views of the discharge taken by intensified charge coupled device reveal that, when the first peak appeared, the discharge luminance moves to the edge of the tube as the magnetic field increases. For the second peak, the strong discharge area is centered at the two antenna legs after the magnetic field reaches a threshold value. Comparing with the simulation, we suggest that the efficient power absorption of two peaks at which the efficient power absorption mainly appears in the near-antenna region is due to the mode conversion in bounded non-uniform helicon plasma. The two low-field peaks are caused, to some extent, by the excitation of Trivelpiece-Gould wave through non-resonance conversion.

  2. Generation of sub-nanosecond pulses using peaking capacitor

    Directory of Open Access Journals (Sweden)

    Madhu Palati

    2017-05-01

    Full Text Available This paper discusses the analysis, simulation and design of a peaking circuit comprising of a peaking capacitor, spark gap and load circuit. The peaking circuit is used along with a 200 kV, 20 J Marx generator for generation of sub-nanosecond pulses. A high pressure chamber to accommodate the peaking circuit was designed and fabricated and tested upto a pressure of 70 kg/cm2. Total estimated values of the capacitance and inductance of the peaking circuit are 10 pF and 72 nH respectively. At full charging voltage, the peaking capacitor gets charged to a peak voltage of 394.6 kV in 15 ns. The output switch is closed at this instant. From Analysis & Simulation, the output current & rise time (with a matched load of 85 Ω are 2.53 kA and 0.62 ns.

  3. Demand Responsive and Energy Efficient Control Technologies andStrategies in Commercial Buildings

    Energy Technology Data Exchange (ETDEWEB)

    Piette, Mary Ann; Kiliccote, Sila

    2006-09-01

    Commercial buildings account for a large portion of summer peak electric demand. Research results show that there is significant potential to reduce peak demand in commercial buildings through advanced control technologies and strategies. However, a better understanding of commercial buildings contribution to peak demand and the use of energy management and control systems is required to develop this demand response resource to its full potential. The main objectives of the study were: (1) To evaluate the size of contributions of peak demand commercial buildings in the U.S.; (2) To understand how commercial building control systems support energy efficiency and DR; and (3) To disseminate the results to the building owners, facility managers and building controls industry. In order to estimate the commercial buildings contribution to peak demand, two sources of data are used: (1) Commercial Building Energy Consumption Survey (CBECS) and (2) National Energy Modeling System (NEMS). These two sources indicate that commercial buildings noncoincidental peak demand is about 330GW. The project then focused on technologies and strategies that deliver energy efficiency and also target 5-10% of this peak. Based on a building operations perspective, a demand-side management framework with three main features: (1) daily energy efficiency, (2) daily peak load management and (3) dynamic, event-driven DR are outlined. A general description of DR, its benefits, and nationwide DR potential in commercial buildings are presented. Case studies involving these technologies and strategies are described. The findings of this project are shared with building owners, building controls industry, researchers and government entities through a webcast and their input is requested. Their input is presented in the appendix section of this report.

  4. Pressure dependence of the Boson peak in poly(butadiene)

    CERN Document Server

    Frick, B

    2002-01-01

    Variation of pressure and temperature in inelastic neutron scattering experiments allows us to separate density and thermal energy contributions. We summarise briefly the influence of pressure and temperature on the dynamic scattering law of the polymer glass former poly(butadiene) far below the glass transition. We also show the advantage of using a liquid-niobium pressure cell in such studies. The effect of pressure on the boson peak is to shift the peak towards higher energies and to reduce the low-frequency modes more strongly below the boson-peak maximum than above. A decrease in the Debye-Waller factor with increasing pressure is observed. (orig.)

  5. Determination of proper peaking time for Ultra-LEGe detector

    Energy Technology Data Exchange (ETDEWEB)

    Karabidak, S.M., E-mail: salihm@ktu.edu.t [Department of Physics, Karadeniz Technical University, 61080 Trabzon (Turkey); Department of Engineering Physics, Guemueshane University, 29100 Guemueshane (Turkey); Kaya, S. [Department of Engineering Physics, Guemueshane University, 29100 Guemueshane (Turkey); Cevik, U. [Department of Physics, Karadeniz Technical University, 61080 Trabzon (Turkey); Celik, A. [Department of Physics, Giresun University, 28049 Giresun (Turkey)

    2011-04-15

    Reducing count losses and pile-up pulse effects in quantitative and qualitative analysis is necessary for accuracy of analysis. Therefore, the proper peaking time for particular detector systems is important. The characteristic X-rays emitted from pure some elements were detected by using an Ultra-LEGe detector connecting a Tennelec TC 244 spectroscopy amplifier at different peaking time modes. Overall pulse widths were determined by an HM 203-7 oscilloscope connecting amplifier. The proper peaking time for Ultra-LEGe is determined as 3.84 {mu}s.

  6. OECD : Euroopa peaks laenuraha odava hoidma / Sirje Rank

    Index Scriptorium Estoniae

    Rank, Sirje, 1966-

    2002-01-01

    USA majanduse kiire toibumine võib varsti tuua laenuintresside tõusu, Euroopa Keskpank peaks vähemalt aasta lõpuni ootama ja laskma kasvul juurduda. Diagramm: OECD tõstis majanduskasvu prognoosi. Maksukoormus

  7. Reducing Electricity Demand Peaks by Scheduling Home Appliances Usage

    DEFF Research Database (Denmark)

    Rossello Busquet, Ana; Kardaras, Georgios; Iversen, Villy Bæk

    2011-01-01

    . On the contrary, the low priority devices have to pause their operation, when the algorithm dictates it, and resume it in the future. This can become beneficial for both energy companies and users. The electricity suppliers companies will be capable of regulating power generation during demand peaks periods....... Moreover, users can be granted lower electricity bill rates for accepting delaying the operation of some of their appliances. In order to analyze this scenario, teletraffic engineering theory, which is used in evaluating the performance of telecommunication networks, is used. A reversible fair scheduling......Nowadays there is a tendency to consume electricity during the same period of the day leading to demand peaks. Regular energy consumption habits lead to demand peaks at specific temporal intervals, because users consume power at the same time. In order to avoid demand peaks, users’ appliances...

  8. Audible thunder characteristic and the relation between peak ...

    Indian Academy of Sciences (India)

    Audible thunder characteristic and the relation between peak frequency and lightning parameters ... In recent summers, some natural lightning optical spectra and audible thunder signals were observed. ... School of Mathematics, Physics and Software Engineering, Lanzhou Jiaotong University, Lanzhou 730 070, China.

  9. Effects of equipment and technique on peak flow measurements

    Directory of Open Access Journals (Sweden)

    O'Driscoll B Ronan

    2006-06-01

    Full Text Available Abstract Background Different lung function equipment and different respiratory manoeuvres may produce different Peak Expiratory Flow (PEF results. Although the PEF is the most common lung function test, there have been few studies of these effects and no previous study has evaluated both factors in a single group of patients. Methods We studied 36 subjects (PEF range 80–570 l/min. All patients recorded PEF measurements using a short rapid expiration following maximal inspiration (PEF technique or a forced maximal expiration to residual volume (FVC technique. Measurements were made using a Wright's peak flow meter, a turbine spirometer and a Fleisch pneumotachograph spirometer. Results The mean PEF was 8.7% higher when the PEF technique was used (compared with FVC technique, p Conclusion Peak flow measurements are affected by the instruction given and by the device and Peak Flow scale used. Patient management decisions should not be based on PEF measurement made on different instruments.

  10. Potential of solar cooling systems for peak demand reduction

    Energy Technology Data Exchange (ETDEWEB)

    Pesaran, A A [National Renewable Energy Lab., Golden, CO (United States); Neymark, J [Neymark (Joel), Golden, CO (United States)

    1994-11-01

    We investigated the technical feasibility of solar cooling for peak demand reduction using a building energy simulation program (DOE2.1D). The system studied was an absorption cooling system with a thermal coefficient of performance of 0.8 driven by a solar collector system with an efficiency of 50% with no thermal storage. The analysis for three different climates showed that, on the day with peak cooling load, about 17% of the peak load could be met satisfactorily with the solar-assisted cooling system without any thermal storage. A performance availability analysis indicated that the solar cooling system should be designed for lower amounts of available solar resources that coincide with the hours during which peak demand reduction is required. The analysis indicated that in dry climates, direct-normal concentrating collectors work well for solar cooling; however, in humid climates, collectors that absorb diffuse radiation work better.

  11. The simple method of determination peaks areas in multiplets

    International Nuclear Information System (INIS)

    Loska, L.; Ptasinski, J.

    1991-01-01

    Semiconductor germanium detectors used in γ-spectrometry give spectra with well-separated peaks. However, in some cases, energies of γ-lines are too near, to produce resolved and undisturbed peaks. Then, there is a necessity to perform a mathematical separation. The method proposed here is based on the assumption, that areas of peaks composing the analysed multiplet are proportional to their heights. The method can be applied for any number of interfering peaks, providing, that the function of the background under the multiplet is accurately determined. The results of testing calculations performed on a simulated spectrum are given. The method works successfully in a computer program used for neutron activation analysis data processing. (author). 9 refs, 1 fig, 1 tab

  12. Desert Peak East Enhanced Geothermal Systems (EGS) Project

    Energy Technology Data Exchange (ETDEWEB)

    Zemach, Ezra [Ormat Technologies Inc., Reno, NV (United States); Drakos, Peter [Ormat Technologies Inc., Reno, NV (United States); Spielman, Paul [Ormat Technologies Inc., Reno, NV (United States); Akerley, John [Ormat Technologies Inc., Reno, NV (United States)

    2013-09-30

    This manuscript is a draft to replaced with a final version at a later date TBD. A summary of activities pertaining to the Desert Peak EGS project including the planning and resulting stimulation activities.

  13. FHWA operations support : port peak pricing program evaluation

    Science.gov (United States)

    2009-01-01

    This report evaluates the applicability, Federal policy implications, and possible public and private sector roles related to peak pricing strategies at ports and intermodal facilities in the U.S. A number of ports and intermodal terminals are consid...

  14. Brian Eno Hollandi Festivali peakülaliseks

    Index Scriptorium Estoniae

    1999-01-01

    Inglise helilooja, videokunstnik ja muusikaprodutsent Brian Eno on 5.-26. juunini Amsterdamis toimuva avangardse Hollandi Festivali peakülaline, kelle videoinstallatsioon seatakse üles Stedelijki Muuseumis. Festivali programmist

  15. Advancements of ultra-high peak power laser diode arrays

    Science.gov (United States)

    Crawford, D.; Thiagarajan, P.; Goings, J.; Caliva, B.; Smith, S.; Walker, R.

    2018-02-01

    Enhancements of laser diode epitaxy in conjunction with process and packaging improvements have led to the availability of 1cm bars capable of over 500W peak power at near-infrared wavelengths (770nm to 1100nm). Advances in cooler design allow for multi-bar stacks with bar-to-bar pitches as low as 350μm and a scalable package architecture enabled a single diode assembly with total peak powers of over 1MegaWatt of peak power. With the addition of micro-optics, overall array brightness greater than 10kW/cm2 was achieved. Performance metrics of barbased diode lasers specifically engineered for high peak power and high brightness at wavelengths and pulse conditions commonly used to pump a variety of fiber and solid-state materials are presented.

  16. Peak globalization. Climate change, oil depletion and global trade

    International Nuclear Information System (INIS)

    Curtis, Fred

    2009-01-01

    The global trade in goods depends upon reliable, inexpensive transportation of freight along complex and long-distance supply chains. Global warming and peak oil undermine globalization by their effects on both transportation costs and the reliable movement of freight. Countering the current geographic pattern of comparative advantage with higher transportation costs, climate change and peak oil will thus result in peak globalization, after which the volume of exports will decline as measured by ton-miles of freight. Policies designed to mitigate climate change and peak oil are very unlikely to change this result due to their late implementation, contradictory effects and insufficient magnitude. The implication is that supply chains will become shorter for most products and that production of goods will be located closer to where they are consumed. (author)

  17. Peak globalization. Climate change, oil depletion and global trade

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, Fred [Department of Economics, Drew University, Madison, NJ 07940 (United States)

    2009-12-15

    The global trade in goods depends upon reliable, inexpensive transportation of freight along complex and long-distance supply chains. Global warming and peak oil undermine globalization by their effects on both transportation costs and the reliable movement of freight. Countering the current geographic pattern of comparative advantage with higher transportation costs, climate change and peak oil will thus result in peak globalization, after which the volume of exports will decline as measured by ton-miles of freight. Policies designed to mitigate climate change and peak oil are very unlikely to change this result due to their late implementation, contradictory effects and insufficient magnitude. The implication is that supply chains will become shorter for most products and that production of goods will be located closer to where they are consumed. (author)

  18. Bedrock Geologic Map of the Jay Peak, VT Quadrangle

    Data.gov (United States)

    Vermont Center for Geographic Information — Digital data from VG99-1 Compilation bedrock geologic map of the Jay Peak quadrangle, Compiled by B. Doolan, 1999: VGS Open-File Report VG99-1, 1 plate, scale...

  19. Periodic transmission peak splitting in one dimensional disordered photonic structures

    Science.gov (United States)

    Kriegel, Ilka; Scotognella, Francesco

    2016-08-01

    In the present paper we present ways to modulate the periodic transmission peaks arising in disordered one dimensional photonic structures with hundreds of layers. Disordered structures in which the optical length nd (n is the refractive index and d the layer thickness) is the same for each layer show regular peaks in their transmission spectra. A proper variation of the optical length of the layers leads to a splitting of the transmission peaks. Notably, the variation of the occurrence of high and low refractive index layers, gives a tool to tune also the width of the peaks. These results are of highest interest for optical application, such as light filtering, where the manifold of parameters allows a precise design of the spectral transmission ranges.

  20. 1.55 Micron High Peak Power Fiber Amplifier Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In this proposal, we propose to demonstrate and build a 1.55 micron single frequency high energy and high peak power fiber amplifier by developing an innovative...

  1. Hubbert's Oil Peak Revisited by a Simulation Model

    International Nuclear Information System (INIS)

    Giraud, P.N.; Sutter, A.; Denis, T.; Leonard, C.

    2010-01-01

    As conventional oil reserves are declining, the debate on the oil production peak has become a burning issue. An increasing number of papers refer to Hubbert's peak oil theory to forecast the date of the production peak, both at regional and world levels. However, in our views, this theory lacks micro-economic foundations. Notably, it does not assume that exploration and production decisions in the oil industry depend on market prices. In an attempt to overcome these shortcomings, we have built an adaptative model, accounting for the behavior of one agent, standing for the competitive exploration-production industry, subjected to incomplete but improving information on the remaining reserves. Our work yields challenging results on the reasons for an Hubbert type peak oil, lying mainly 'above the ground', both at regional and world levels, and on the shape of the production and marginal cost trajectories. (authors)

  2. Energy loss minimization through peak shaving using energy storage

    Directory of Open Access Journals (Sweden)

    Vaiju Kalkhambkar

    2016-09-01

    Full Text Available This paper presents an optimal placement methodology of energy storage to improve energy loss minimization through peak shaving in the presence of renewable distributed generation. Storage sizing is modelled by considering the load profile and desired peak shaving. This storage is suitably divided into multiple storage units and optimally allocated at multiple sites with suitable charge discharge strategy. Thus the peak shaving for maximum loss reduction is explored here. Renewable distributed generation (RDG is modelled based on the seasonal variations of renewable resources e.g., solar or wind and these RDGs are placed at suitable locations. A high-performance Grey Wolf Optimization (GWO algorithm is applied to the proposed methodology. The results are compared with the well-known genetic algorithm. The proposed methodology is illustrated by various case studies on a 34-bus test system. Significant loss minimization is obtained by optimal location of multiple energy storage units through peak shaving.

  3. The economic impact of emission peaking control policies and China's sustainable development

    Directory of Open Access Journals (Sweden)

    Yi Wang

    2014-12-01

    Full Text Available To achieve the goals of national sustainable development, the peaking control of CO2 emissions is pivotal, as well as other pollutants. In this paper, we build a Chinese inter-regional CGE model and simulate 13 policies and their combinations. By analyzing the energy consumptions, coal consumptions, relating emissions and their impacts on GDP, we found that with the structure adjustment policy, the proportion of coal in primary fossil fuels in 2030 will decrease from 53% to 48% and CO2 emissions will decrease by 11.3%–22.8% compared to the baseline scenario. With the energy intensity reduction policy, CO2 emissions will decrease by 33.3% in 2030 and 47.8% in 2050 than baseline scenario. Other pollutants will also be controlled as synergetic effects. In this study we also find that although the earlier the peaking time the better for emission amounts control, the economic costs can not be ignored. The GDP will decrease by 2.96%–8.23% under different scenarios. Therefore, integrated policy solutions are needed for realizing the peaks package and more targeted measures are required to achieve the peaks of other pollutants earlier.

  4. Trust and the Welfare State: The Twin Peaks Curve

    OpenAIRE

    Yann Algan; Pierre Cahuc; Marc Sangnier

    2014-01-01

    We show the existence of a twin peaks relation between trust and the size of the welfare state that stems from two opposing forces. Uncivic people support large welfare states because they expect to benefit from them without bearing their costs. But civic individuals support generous benefits and high taxes only when they are surrounded by trustworthy individuals. We provide empirical evidence for these behaviors and this twin peaks relation in the OECD countries.

  5. Converter for Measurement of non-sinusoidal current peak value

    DEFF Research Database (Denmark)

    Butvin, P.; Nielsen, Otto V; Brauer, Peter

    1997-01-01

    A linear-response toroid with core wound of rapidly quenched soft magnetic metallic ribbon and fitted with two windings is used to enable correct measurement of mean peak value of non-sinusoidal and not noise-free alternating current.......A linear-response toroid with core wound of rapidly quenched soft magnetic metallic ribbon and fitted with two windings is used to enable correct measurement of mean peak value of non-sinusoidal and not noise-free alternating current....

  6. Mineral Resources: Reserves, Peak Production and the Future

    OpenAIRE

    Lawrence D. Meinert; Gilpin R. Robinson; Nedal T. Nassar

    2016-01-01

    The adequacy of mineral resources in light of population growth and rising standards of living has been a concern since the time of Malthus (1798), but many studies erroneously forecast impending peak production or exhaustion because they confuse reserves with “all there is”. Reserves are formally defined as a subset of resources, and even current and potential resources are only a small subset of “all there is”. Peak production or exhaustion cannot be modeled accurately from reserves. Using ...

  7. Peak effect at microwave frequencies in swift heavy ion irradiated ...

    Indian Academy of Sciences (India)

    The vortex dynamics at microwave frequencies in YBa2Cu3O7- (YBCO) films have been studied. We observe a peak in the microwave (4.88 and 9.55 GHz) surface resistance in some films in magnetic fields up to 0.8 T. This is associated with the `peak-effect' phenomenon and reflects the order–disorder transformation of ...

  8. From chemical graphs in computer-aided drug design to general Markov-Galvez indices of drug-target, proteome, drug-parasitic disease, technological, and social-legal networks.

    Science.gov (United States)

    Riera-Fernández, Pablo; Munteanu, Cristian R; Dorado, Julian; Martin-Romalde, Raquel; Duardo-Sanchez, Aliuska; González-Diaz, Humberto

    2011-12-01

    Complex Networks are useful in solving problems in drug research and industry, developing mathematical representations of different systems. These systems move in a wide range from relatively simple graph representations of drug molecular structures to large systems. We can cite for instance, drug-target protein interaction networks, drug policy legislation networks, or drug treatment in large geographical disease spreading networks. In any case, all these networks have essentially the same components: nodes (atoms, drugs, proteins, microorganisms and/or parasites, geographical areas, drug policy legislations, etc.) and edges (chemical bonds, drug-target interactions, drug-parasite treatment, drug use, etc.). Consequently, we can use the same type of numeric parameters called Topological Indices (TIs) to describe the connectivity patterns in all these kinds of Complex Networks despite the nature of the object they represent. The main reason for this success of TIs is the high flexibility of this theory to solve in a fast but rigorous way many apparently unrelated problems in all these disciplines. Another important reason for the success of TIs is that using these parameters as inputs we can find Quantitative Structure-Property Relationships (QSPR) models for different kind of problems in Computer-Aided Drug Design (CADD). Taking into account all the above-mentioned aspects, the present work is aimed at offering a common background to all the manuscripts presented in this special issue. In so doing, we make a review of the most common types of complex networks involving drugs or their targets. In addition, we review both classic TIs that have been used to describe the molecular structure of drugs and/or larger complex networks. Next, we use for the first time a Markov chain model to generalize Galvez TIs to higher order analogues coined here as the Markov-Galvez TIs of order k (MGk). Lastly, we illustrate the calculation of MGk values for different classes of

  9. Peaking of world oil production: Impacts, mitigation, & risk management

    Energy Technology Data Exchange (ETDEWEB)

    Hirsch, R.L. (SAIC); Bezdek, Roger (MISI); Wendling, Robert (MISI)

    2005-02-01

    The peaking of world oil production presents the U.S. and the world with an unprecedented risk management problem. As peaking is approached, liquid fuel prices and price volatility will increase dramatically, and, without timely mitigation, the economic, social, and political costs will be unprecedented. Viable mitigation options exist on both the supply and demand sides, but to have substantial impact, they must be initiated more than a decade in advance of peaking.... The purpose of this analysis was to identify the critical issues surrounding the occurrence and mitigation of world oil production peaking. We simplified many of the complexities in an effort to provide a transparent analysis. Nevertheless, our study is neither simple nor brief. We recognize that when oil prices escalate dramatically, there will be demand and economic impacts that will alter our simplified assumptions. Consideration of those feedbacks will be a daunting task but one that should be undertaken. Our aim in this study is to-- • Summarize the difficulties of oil production forecasting; • Identify the fundamentals that show why world oil production peaking is such a unique challenge; • Show why mitigation will take a decade or more of intense effort; • Examine the potential economic effects of oil peaking; • Describe what might be accomplished under three example mitigation scenarios. • Stimulate serious discussion of the problem, suggest more definitive studies, and engender interest in timely action to mitigate its impacts.

  10. Dual peak cholera transmission in Bengal Delta: A hydroclimatological explanation

    Science.gov (United States)

    Akanda, Ali Shafqat; Jutla, Antarpreet Singh; Islam, Shafiqul

    2009-10-01

    Cholera has reemerged as a global killer with the world witnessing an unprecedented rise in cholera infection and transmission since the 1990s. Cholera outbreaks across most affected areas show infection patterns with a single annual peak. However, cholera incidences in the Bengal Delta region, the native homeland of cholera, show bi-annual peaks. The mechanisms behind this unique seasonal dual peak phenomenon in cholera dynamics, especially the role of climatic and hydrologic variables, are not fully understood. Here, we show that low flow in the Brahmaputra and the Ganges during spring is associated with the first outbreaks of cholera in Bangladesh; elevated spring cholera outbreaks are seen in low discharge years. Peak streamflow of these rivers, on the other hand, create a different cholera transmission environment; peak flood volumes and extent of flood-affected areas during monsoon are responsible for autumn cholera outbreaks. Our results demonstrate how regional hydroclimatology may explain the seasonality and dual peaks of cholera incidence in the Bengal Delta region. A quantitative understanding of the relationships among the hydroclimatological drivers and seasonal cholera outbreaks will help early cholera detection and prevention efforts.

  11. Predicting durations of online collective actions based on Peaks' heights

    Science.gov (United States)

    Lu, Peng; Nie, Shizhao; Wang, Zheng; Jing, Ziwei; Yang, Jianwu; Qi, Zhongxiang; Pujia, Wangmo

    2018-02-01

    Capturing the whole process of collective actions, the peak model contains four stages, including Prepare, Outbreak, Peak, and Vanish. Based on the peak model, one of the key variables, factors and parameters are further investigated in this paper, which is the rate between peaks and spans. Although the durations or spans and peaks' heights are highly diversified, it seems that the ratio between them is quite stable. If the rate's regularity is discovered, we can predict how long the collective action lasts and when it ends based on the peak's height. In this work, we combined mathematical simulations and empirical big data of 148 cases to explore the regularity of ratio's distribution. It is indicated by results of simulations that the rate has some regularities of distribution, which is not normal distribution. The big data has been collected from the 148 online collective actions and the whole processes of participation are recorded. The outcomes of empirical big data indicate that the rate seems to be closer to being log-normally distributed. This rule holds true for both the total cases and subgroups of 148 online collective actions. The Q-Q plot is applied to check the normal distribution of the rate's logarithm, and the rate's logarithm does follow the normal distribution.

  12. Optimizing deep hyperthermia treatments: are locations of patient pain complaints correlated with modelled SAR peak locations?

    Science.gov (United States)

    Canters, R. A. M.; Franckena, M.; van der Zee, J.; van Rhoon, G. C.

    2011-01-01

    During deep hyperthermia treatment, patient pain complaints due to heating are common when maximizing power. Hence, there exists a good rationale to investigate whether the locations of predicted SAR peaks by hyperthermia treatment planning (HTP) are correlated with the locations of patient pain during treatment. A retrospective analysis was performed, using the treatment reports of 35 patients treated with deep hyperthermia controlled by extensive treatment planning. For various SAR indicators, the average distance from a SAR peak to a patient discomfort location was calculated, for each complaint. The investigated V0.1 closest (i.e. the part of the 0.1th SAR percentile closest to the patient complaint) performed the best, and leads to an average distance between the SAR peak and the complaint location of 3.9 cm. Other SAR indicators produced average distances that were all above 10 cm. Further, the predicted SAR peak location with V0.1 provides a 77% match with the region of complaint. The current study demonstrates that HTP is able to provide a global indication of the regions where hotspots during treatment will most likely occur. Further development of this technology is necessary in order to use HTP as a valuable toll for objective and advanced SAR steering. The latter is especially valid for applications that enable 3D SAR steering.

  13. Spatial and temporal changes of vegetation information in the karst peak cluster area, Guilin

    Science.gov (United States)

    Liu, Chao; Wu, Hong

    2014-05-01

    The karst peak clusters are main type of Karst landscape interspersed along Li River in Guilin. Their situation of ecological environment has impact on the environmental change of Guilin city directly and indirectly. To study the temporal and spatial characteristics of the impacts, two determinate region information, NDVI and TC2 were extracted from Landsat TM data at the eight areas of Karst peak cluster. The results showed that the values of NDVI and TC2 of the some karst peak cluster have changing trend from high to low then higher for different time, that is, from 1986, 1991 to 2006, and the values of NDVI TC2 of the different Karst peak cluster are different for same period time. It has relation in value from high to low, that is, No.5>No.4>No.3>No.8>No.7>No.6>No.2>No. As a result, ecological environment of Guilin city has underground unsymmetrical change in time and space during past 20 years namely from 1986 to 2006. The studying achievement can be foundation in science and technology for synthetically govern to ecological environment of Guilin city in 21 century.

  14. Practical biological spread-out Bragg peak design for a carbon beam

    Science.gov (United States)

    Kim, Chang Hyeuk; Lee, Hwa-Ryun; Chang, Seduk; Jang, Hong Suk; Kim, Jeong Hwan; Park, Dong Wook; Hwang, Won Taek; Yang, Tea-Keun

    2015-10-01

    In radiation therapy, the carbon beams has more advantages with respect to biological properties then a proton beam. The carbon beam has a high linear energy transfer (LET) to the medium and a higher relative biological effectiveness (RBE). To design the spread-out Bragg peak (SOBP) of biological dose for a carbon beam, we propose a practical method using the linear-quadratic (LQ) model and the Geant4-based Monte Carlo simulation code. Various Bragg peak profiles and LETs were calculated for each slice in the target region. To generate an appropriate biological SOBP, we applied a set of weighting factors, which are power functions in terms of energy steps, to each obtained physical dose. The designed biological SOBP showed a uniformity of 1.34%.

  15. Targeted Learning

    CERN Document Server

    van der Laan, Mark J

    2011-01-01

    The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the targe

  16. Impact of roof integrated PV orientation on the residential electricity peak demand

    International Nuclear Information System (INIS)

    Sadineni, Suresh B.; Atallah, Fady; Boehm, Robert F.

    2012-01-01

    Highlights: ► A study to demonstrate peak load reductions at the substation. ► A new residential energy efficient community named Villa Trieste is being developed. ► The peak demand from the homes has decreased by 38% through energy efficiency. ► Orientation of roof integrated PV has less influence on the summer peak demand. ► Increasing thermostat temperature during peak by 1 °C can significantly reduce peaks. -- Abstract: Peak electricity demand has been an issue in the Desert Southwest region of the US, due to extreme summer temperatures. To address this issue, a consortium was formed between the University of Nevada, Las Vegas, Pulte Homes, and NV Energy. An energy efficient residential community was developed by the team in Las Vegas with approximately 200 homes to study substation-level peak reduction strategies. A summer peak reduction of more than 65%, between 1:00 PM and 7:00 PM, compared to code standard housing developments is the targeted goal of the project. Approximately 50 homes are already built and some are occupied. The energy performances of the homes have been monitored and are presented in this paper. Several peak electric load reduction strategies such as energy efficiency in buildings, roof integrated photovoltaics (PV) and direct load control have been applied. Though all the homes in the developed community are installed with 1.8 kW p PV systems, the orientation of the PV system depends on the building orientation. Focus of this paper is to find the impact of PV orientation on the peak load from a building. In addition, different time-of-use (TOU) energy pricing options are offered by the local electrical utility company. Hence it is important to find an optimal pricing option for each building. A computer model has been developed for one of the homes in the new development using building energy simulation code, ENERGY-10. Calculations on the PV orientations have shown that a south and 220° (i.e. 40° west of due south

  17. Automatic fitting of Gaussian peaks using abductive machine learning

    Science.gov (United States)

    Abdel-Aal, R. E.

    1998-02-01

    Analytical techniques have been used for many years for fitting Gaussian peaks in nuclear spectroscopy. However, the complexity of the approach warrants looking for machine-learning alternatives where intensive computations are required only once (during training), while actual analysis on individual spectra is greatly simplified and quickened. This should allow the use of simple portable systems for fast and automated analysis of large numbers of spectra, particularly in situations where accuracy may be traded for speed and simplicity. This paper proposes the use of abductive networks machine learning for this purpose. The Abductory Induction Mechanism (AIM) tool was used to build models for analyzing both single and double Gaussian peaks in the presence of noise depicting statistical uncertainties in collected spectra. AIM networks were synthesized by training on 1000 representative simulated spectra and evaluated on 500 new spectra. A classifier network determines the multiplicity of single/double peaks with an accuracy of 5.8%. With statistical uncertainties corresponding to a peak count of 100, average percentage absolute errors for the height, position, and width of single peaks are 4.9, 2.9, and 4.2%, respectively. For double peaks, these average errors are within 7.0, 3.1, and 5.9%, respectively. Models have been developed which account for the effect of a linear background on a single peak. Performance is compared with a neural network application and with an analytical curve-fitting routine, and the new technique is applied to actual data of an alpha spectrum.

  18. Peak Operation of Cascaded Hydropower Plants Serving Multiple Provinces

    Directory of Open Access Journals (Sweden)

    Jianjian Shen

    2015-10-01

    Full Text Available The bulk hydropower transmission via trans-provincial and trans-regional power networks in China provides great operational flexibility to dispatch power resources between multiple power grids. This is very beneficial to alleviate the tremendous peak load pressure of most provincial power grids. This study places the focus on peak operations of cascaded hydropower plants serving multiple provinces under a regional connected AC/DC network. The objective is to respond to peak loads of multiple provincial power grids simultaneously. A two-stage search method is developed for this problem. In the first stage, a load reconstruction strategy is proposed to combine multiple load curves of power grids into a total load curve. The purpose is to deal with different load features in load magnitudes, peaks and valleys. A mutative-scale optimization method is then used to determine the generation schedules of hydropower plants. In the second stage, an exterior point search method is established to allocate the generation among multiple receiving power grids. This method produces an initial solution using the load shedding algorithm, and further improves it by iteratively coordinating the generation among different power grids. The proposed method was implemented to the operations of cascaded hydropower plants on Xin-Fu River and another on Hongshui River. The optimization results in two cases satisfied the peak demands of receiving provincial power grids. Moreover, the maximum load difference between peak and valley decreased 12.67% and 11.32% in Shanghai Power Grid (SHPG and Zhejiang Power Grid (ZJPG, exceeding by 4.85% and 6.72% those of the current operational method, respectively. The advantage of the proposed method in alleviating peak-shaving pressure is demonstrated.

  19. The duration of pubertal growth peak among three skeletal classes

    Directory of Open Access Journals (Sweden)

    Waqar Jeelani

    Full Text Available ABSTRACT Introduction: Pubertal growth peak is closely associated with a rapid increase in mandibular length and offers a wide range of therapeutic modifiability. Objective: The aim of the present study was to determine and compare the mean ages of onset and duration of pubertal growth peak among three skeletal classes. Methods: A retrospective cross-sectional study was conducted using lateral cephalograms of 230 subjects with growth potential (110 males, 120 females. Subjects were categorized into three classes (Class I = 81, Class II = 82, Class III = 67, according to the sagittal relationship established between the maxilla and the mandible. The cervical vertebral maturation stage was recorded by means of Baccetti's method. The mean ages at CS3 and CS4 and the CS3-CS4 age interval were compared between boys and girls and among three skeletal classes. Results: Pubertal growth peak occurred on average four months earlier in girls than boys (p = 0.050. The average duration of pubertal growth peak was 11 months in Class I, seven months in Class II and 17 months in Class III subjects. Interclass differences were highly significant (Cohen's d > 0.08. However, no significant difference was found in the timing of pubertal growth peak onset among three skeletal classes (p = 0.126 in boys, p = 0.262 in girls. Conclusions: Girls enter pubertal growth peak on average four months earlier than boys. Moreover, the duration of pubertal growth peak is on average four months shorter in Class II and six months longer in Class III subjects as compared to Class I subjects.

  20. Superoxide dismutase levels and peak expiratory flow in asthmatic children

    Directory of Open Access Journals (Sweden)

    Arie Kurniasih

    2016-11-01

    Full Text Available Background Asthma is a chronic inflammatory process which involve variety of cells such as inflammatory mediators, reactive oxygen species (ROS, and cytokines. The inflammatory process would be exacerbated in the presence of oxidative stress. Superoxide dismutase (SOD is the first important enzyme to protect the respiratory tract against oxidative stress. The decreased of SOD has a correlation with increased of airway obstruction and bronchospasm. Objective To assess for a correlation between superoxide dismutase (SOD levels and peak expiratory flow, as well as to determine the impact of SOD levels for predicting asthma attacks. Methods We conducted a prospective cohort study at Dr. Sardjito Hospital, Yogyakarta, between February and April 2011 involving asthmatic children aged 5-18 years. Subjects’ serum SOD levels and peak expiratory flow were measured at the same time point. We then performed a prospective study following up on the same subjects to find out if they had a recurrent asthma attack within one month of the tests. We also reassessed their peak expiratory flow one month after blood specimens were obtained. Results Thirty-nine patients were enrolled in this study. There was no significant correlation between SOD level and peak expiratory flow [r=0.289; 95%CI -0.025 to 0.47; P=0.074]. However, older age was significantly associated with higher peak expiratory flow (=0.5; 95%CI 3.10 to 11.57; P=0.01. Lower levels of SOD increased the risk of asthma attacks in a month following the initial measurements (RR=5.5; 95%CI 1.6 to 18.9; P=0.009. Conclusion Superoxide dismutase (SOD level is not significantly associated with peak expiratory flow. However, we find a relationship between older age and higher peak expiratory flow and a relationship between lower SOD levels and risk of asthma attacks within one month following the tests.

  1. Automatic fitting of Gaussian peaks using abductive machine learning

    International Nuclear Information System (INIS)

    Abdel-Aal, R.E.

    1998-01-01

    Analytical techniques have been used for many years for fitting Gaussian peaks in nuclear spectroscopy. However, the complexity of the approach warrants looking for machine-learning alternatives where intensive computations are required only once (during training), while actual analysis on individual spectra is greatly simplified and quickened. This should allow the use of simple portable systems for fast and automated analysis of large numbers of spectra, particularly in situations where accuracy may be traded for speed and simplicity. This paper proposes the use of abductive networks machine learning for this purpose. The Abductory Induction Mechanism (AIM) tool was used to build models for analyzing both single and double Gaussian peaks in the presence of noise depicting statistical uncertainties in collected spectra. AIM networks were synthesized by training on 1,000 representative simulated spectra and evaluated on 500 new spectra. A classifier network determines the multiplicity of single/double peaks with an accuracy of 98%. With statistical uncertainties corresponding to a peak count of 100, average percentage absolute errors for the height, position, and width of single peaks are 4.9, 2.9, and 4.2%, respectively. For double peaks, these average errors are within 7.0, 3.1, and 5.9%, respectively. Models have been developed which account for the effect of a linear background on a single peak. Performance is compared with a neural network application and with an analytical curve-fitting routine, and the new technique is applied to actual data of an alpha spectrum

  2. flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding.

    Science.gov (United States)

    Ge, Yongchao; Sealfon, Stuart C

    2012-08-01

    For flow cytometry data, there are two common approaches to the unsupervised clustering problem: one is based on the finite mixture model and the other on spatial exploration of the histograms. The former is computationally slow and has difficulty to identify clusters of irregular shapes. The latter approach cannot be applied directly to high-dimensional data as the computational time and memory become unmanageable and the estimated histogram is unreliable. An algorithm without these two problems would be very useful. In this article, we combine ideas from the finite mixture model and histogram spatial exploration. This new algorithm, which we call flowPeaks, can be applied directly to high-dimensional data and identify irregular shape clusters. The algorithm first uses K-means algorithm with a large K to partition the cell population into many small clusters. These partitioned data allow the generation of a smoothed density function using the finite mixture model. All local peaks are exhaustively searched by exploring the density function and the cells are clustered by the associated local peak. The algorithm flowPeaks is automatic, fast and reliable and robust to cluster shape and outliers. This algorithm has been applied to flow cytometry data and it has been compared with state of the art algorithms, including Misty Mountain, FLOCK, flowMeans, flowMerge and FLAME. The R package flowPeaks is available at https://github.com/yongchao/flowPeaks. yongchao.ge@mssm.edu Supplementary data are available at Bioinformatics online.

  3. Analysis of Peak-to-Peak Current Ripple Amplitude in Seven-Phase PWM Voltage Source Inverters

    Directory of Open Access Journals (Sweden)

    Gabriele Grandi

    2013-08-01

    Full Text Available Multiphase systems are nowadays considered for various industrial applications. Numerous pulse width modulation (PWM schemes for multiphase voltage source inverters with sinusoidal outputs have been developed, but no detailed analysis of the impact of these modulation schemes on the output peak-to-peak current ripple amplitude has been reported. Determination of current ripple in multiphase PWM voltage source inverters is important for both design and control purposes. This paper gives the complete analysis of the peak-to-peak current ripple distribution over a fundamental period for multiphase inverters, with particular reference to seven-phase VSIs. In particular, peak-to-peak current ripple amplitude is analytically determined as a function of the modulation index, and a simplified expression to get its maximum value is carried out. Although reference is made to the centered symmetrical PWM, being the most simple and effective solution to maximize the DC bus utilization, leading to a nearly-optimal modulation to minimize the RMS of the current ripple, the analysis can be readily extended to either discontinuous or asymmetrical modulations, both carrier-based and space vector PWM. A similar approach can be usefully applied to any phase number. The analytical developments for all different sub-cases are verified by numerical simulations.

  4. Kidney–targeted drug delivery systems

    Directory of Open Access Journals (Sweden)

    Peng Zhou

    2014-02-01

    Full Text Available Kidney-targeted drug delivery systems represent a promising technology to improve drug efficacy and safety in the treatment of renal diseases. In this review, we summarize the strategies that have been employed to develop kidney-targeted drug delivery systems. We also describe how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney. New technologies render it possible to create renal targeting conjugates and other delivery systems including nanoparticles and liposomes present promising strategies to achieve the goal of targeting drugs to the kidney.

  5. Modelling Recycling Targets

    DEFF Research Database (Denmark)

    hill, amanda; Leinikka Dall, Ole; Andersen, Frits Møller

    2014-01-01

    Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22......% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This study integrates the recycling target into the FRIDA model to project how much waste and from which streams should be diverted from incineration to recycling in order to achieve the target. Furthermore, it discusses how...... the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish municipalities...

  6. An online peak extraction algorithm for ion mobility spectrometry data.

    Science.gov (United States)

    Kopczynski, Dominik; Rahmann, Sven

    2015-01-01

    Ion mobility (IM) spectrometry (IMS), coupled with multi-capillary columns (MCCs), has been gaining importance for biotechnological and medical applications because of its ability to detect and quantify volatile organic compounds (VOC) at low concentrations in the air or in exhaled breath at ambient pressure and temperature. Ongoing miniaturization of spectrometers creates the need for reliable data analysis on-the-fly in small embedded low-power devices. We present the first fully automated online peak extraction method for MCC/IMS measurements consisting of several thousand individual spectra. Each individual spectrum is processed as it arrives, removing the need to store the measurement before starting the analysis, as is currently the state of the art. Thus the analysis device can be an inexpensive low-power system such as the Raspberry Pi. The key idea is to extract one-dimensional peak models (with four parameters) from each spectrum and then merge these into peak chains and finally two-dimensional peak models. We describe the different algorithmic steps in detail and evaluate the online method against state-of-the-art peak extraction methods.

  7. Rotational and peak torque stiffness of rugby shoes.

    Science.gov (United States)

    Ballal, Moez S; Usuelli, Federico Giuseppe; Montrasio, Umberto Alfieri; Molloy, Andy; La Barbera, Luigi; Villa, Tomaso; Banfi, Giuseppe

    2014-09-01

    Sports people always strive to avoid injury. Sports shoe designs in many sports have been shown to affect traction and injury rates. The aim of this study is to demonstrate the differing stiffness and torque in rugby boots that are designed for the same effect. Five different types of rugby shoes commonly worn by scrum forwards were laboratory tested for rotational stiffness and peak torque on a natural playing surface generating force patterns that would be consistent with a rugby scrum. The overall internal rotation peak torque was 57.75±6.26 Nm while that of external rotation was 56.55±4.36 Nm. The Peak internal and external rotational stiffness were 0.696±0.1 and 0.708±0.06 Nm/deg respectively. Our results, when compared to rotational stiffness and peak torques of football shoes published in the literature, show that shoes worn by rugby players exert higher rotational and peak torque stiffness compared to football shoes when tested on the same natural surfaces. There was significant difference between the tested rugby shoes brands. In our opinion, to maximize potential performance and lower the potential of non-contact injury, care should be taken in choosing boots with stiffness appropriate to the players main playing role. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Energy Saving by Chopping off Peak Demand Using Day Light

    Directory of Open Access Journals (Sweden)

    Ashok Kumar Maitra

    2011-08-01

    Full Text Available An artificial intelligent technique has been implemented in this research using real time datas to calculate how much energy can be chopped from peak load demand. The results are based on real time data that are taken from power delivering centers. These datas do reflect the present condition of power and a solution to those critical conditions during the peak period. These are done in such a way such that helps in judicious scheduling of load. The time based load scheduling has been done so as to understand the basic criteria for solving power crisis during morning peak and early evening peak. The sunray availability and percentage of load that will use day light saving (DLS technique has been taken into account in this work. The results shows that about 0.5% to 1% of load can be shedded off from the peak load period which otherwise is reduction of power. Thus it otherwise also means that an equivalent amount of energy is saved which amounts to a large saving of national money. This result is obtained on monthly and even daily basis. Thus this paper justifies DLS gives a new renewable technique to save energy.

  9. Lightning peak current estimation using a system identification approach

    Science.gov (United States)

    Wern, T. L. T.; Mukerjee, R. N.

    2006-01-01

    A system identification-based lightning peak current estimation algorithm using upper-air radiosonde observations is developed. The preceding convective and precipitative process leading to thunder cloud formation followed by the cloud electrification and the leader processes together with return stroke and the discharge process, is identified by considering it as a deterministic dynamic system, whose undisturbed and unmeasurable output signal the lightning peak current, is contaminated with a stochastic disturbance. The model parameters determined thus, are used to predict the likely temporal lightning return stroke peak current magnitudes. Two alternative parametric estimation models namely Autoregressive with Exogeneous Input (ARX) and Autoregressive with Moving-Average Exogeneous Input (ARMAX) are used to estimate model parameters of the pilot study area and predict the likely lightning return stroke peak current in each case. The relative performances of the models are compared to determine the best model for application in 12-hour and 24-hour ahead predictions. For a short-term (12 hour) prediction, ARMAX2921 giving a best fit of 78.8429% turns out to be the most suitable model. For a longer (24 hour) prediction, the ARX291, giving a best fit of 75.0181% emerges to be the suitable model. These preliminary results indicate that lightning peak current may be estimated to a good performance using upper-air radiosonde observations.

  10. Group Elevator Peak Scheduling Based on Robust Optimization Model

    Directory of Open Access Journals (Sweden)

    ZHANG, J.

    2013-08-01

    Full Text Available Scheduling of Elevator Group Control System (EGCS is a typical combinatorial optimization problem. Uncertain group scheduling under peak traffic flows has become a research focus and difficulty recently. RO (Robust Optimization method is a novel and effective way to deal with uncertain scheduling problem. In this paper, a peak scheduling method based on RO model for multi-elevator system is proposed. The method is immune to the uncertainty of peak traffic flows, optimal scheduling is realized without getting exact numbers of each calling floor's waiting passengers. Specifically, energy-saving oriented multi-objective scheduling price is proposed, RO uncertain peak scheduling model is built to minimize the price. Because RO uncertain model could not be solved directly, RO uncertain model is transformed to RO certain model by elevator scheduling robust counterparts. Because solution space of elevator scheduling is enormous, to solve RO certain model in short time, ant colony solving algorithm for elevator scheduling is proposed. Based on the algorithm, optimal scheduling solutions are found quickly, and group elevators are scheduled according to the solutions. Simulation results show the method could improve scheduling performances effectively in peak pattern. Group elevators' efficient operation is realized by the RO scheduling method.

  11. Thermal Peak Management Using Organic Phase Change Materials for Latent Heat Storage in Electronic Applications

    Directory of Open Access Journals (Sweden)

    Jacob Maxa

    2017-12-01

    Full Text Available Modern high power electronics devices consists of a large amount of integrated circuits for switching and supply applications. Beside the benefits, the technology exhibits the problem of an ever increasing power density. Nowadays, heat sinks that are directly mounted on a device, are used to reduce the on-chip temperature and dissipate the thermal energy to the environment. This paper presents a concept of a composite coating for electronic components on printed circuit boards or electronic assemblies that is able to buffer a certain amount of thermal energy, dissipated from a device. The idea is to suppress temperature peaks in electronic components during load peaks or electronic shorts, which otherwise could damage or destroy the device, by using a phase change material to buffer the thermal energy. The phase change material coating could be directly applied on the chip package or the PCB using different mechanical retaining jigs.

  12. Thermal Peak Management Using Organic Phase Change Materials for Latent Heat Storage in Electronic Applications

    Science.gov (United States)

    Maxa, Jacob; Novikov, Andrej; Nowottnick, Mathias

    2017-01-01

    Modern high power electronics devices consists of a large amount of integrated circuits for switching and supply applications. Beside the benefits, the technology exhibits the problem of an ever increasing power density. Nowadays, heat sinks that are directly mounted on a device, are used to reduce the on-chip temperature and dissipate the thermal energy to the environment. This paper presents a concept of a composite coating for electronic components on printed circuit boards or electronic assemblies that is able to buffer a certain amount of thermal energy, dissipated from a device. The idea is to suppress temperature peaks in electronic components during load peaks or electronic shorts, which otherwise could damage or destroy the device, by using a phase change material to buffer the thermal energy. The phase change material coating could be directly applied on the chip package or the PCB using different mechanical retaining jigs.

  13. Maximizing the peak production rate in off-line comprehensive two-dimensional liquid chromatography with mass spectrometry detection

    NARCIS (Netherlands)

    Eeltink, S.; Dolman, S.; Ursem, M.; Swart, R.; McLeod, F.; Schoenmakers, P.J.

    2009-01-01

    This article describes an optimization strategy to obtain the best possible performance in the shortest analysis time—called the peak production rate—for comprehensive off-line two-dimensional liquid chromatography. The demands on column technology (particle size and column length) and LC conditions

  14. A Multimethod analysis of the Phenomenon of Peak-Oil

    OpenAIRE

    Kerschner, Christian

    2012-01-01

    El concepto de Peak-Oil (el cénit del petróleo) es complejo y a menudo malentendido. Después de aclarar que el Peak-Oil es tanto un problema de estocs como de flujos, se ofrecen los conceptos de calidad y cantidad del recurso para facilitar la comprensión de la multitud de temas que influyen en el momento del cénit del petróleo y sus posibles impactos. Una revisión de la literatura y las últimas evidencias sugieren que hay un alto riesgo de que el Peak-Oil ocurra antes de 2020, dejando poco t...

  15. Maximizing utilization of sport halls during peak hours

    DEFF Research Database (Denmark)

    Iversen, Evald Bundgård; Forsberg, Peter

    the number of participants 7.5 persons higher pr. activity compared to club activities. This implies that clubs during peak hours could include more participants. Another possibility to increase utilization is if the management of sport facilities forced sport clubs and other organisers to adapt......BACKGROUNDDuring peak hours (4.30pm-8pm) demand for timeslots in sport halls in Denmark are high and there are few timeslots available. Further, focus on how public resources are spent most efficient is increasing (Iversen, 2013). This makes it interesting to analyse how utilization could...... be increased during peak hours. DATA AND METHODOLOGYData is collected by observation of activities during two weeks on for example whether halls are used or not; the amount of playing field used; and number of participants (Iversen, 2012). Data on 1.331 activities in 36 sport halls across 4 municipalities have...

  16. Shocked materials from the Dutch Peak diamictite, Utah

    Science.gov (United States)

    Hoerz, F.; Bunch, T. E.; Oberbeck, V. R.

    1994-01-01

    Evidence of shock metamorphism in the Dutch Peak diamictite in the Sheeprock Mountains, Utah, is reported. The Dutch Peak diamictite is of Proterozoic age and is a minor part of the Dutch Peak formation. A shocked sample, specimen A250, was collected during a brief visit of the Harker Canyon area of the Sheeprock Mountains. This sample consists of equant, anhedral grains of quartz, K-feldspar, and plagioclase. The crystallographic orientation of 244 lamellae systems in 106 grains was measured. It is presently difficult to evaluate the significance of this single specimen. Without additional and substantial field work, and petrographic characterization of this formation, a number of scenarios for the presence of a shocked clast and the emplacement of the entire formation remain viable.

  17. The Peak Pairs algorithm for strain mapping from HRTEM images

    Energy Technology Data Exchange (ETDEWEB)

    Galindo, Pedro L. [Departamento de Lenguajes y Sistemas Informaticos, CASEM, Universidad de Cadiz, Pol. Rio San Pedro s/n. 11510, Puerto Real, Cadiz (Spain)], E-mail: pedro.galindo@uca.es; Kret, Slawomir [Institute of Physics, PAS, AL. Lotnikow 32/46, 02-668 Warsaw (Poland); Sanchez, Ana M. [Departamento de Ciencia de los Materiales e Ing. Metalurgica y Q. Inorganica, Facultad de Ciencias, Universidad de Cadiz, Pol. Rio San Pedro s/n. 11510, Puerto Real, Cadiz (Spain); Laval, Jean-Yves [Laboratoire de Physique du Solide, UPR5 CNRS-ESPCI, Paris (France); Yanez, Andres; Pizarro, Joaquin; Guerrero, Elisa [Departamento de Lenguajes y Sistemas Informaticos, CASEM, Universidad de Cadiz, Pol. Rio San Pedro s/n. 11510, Puerto Real, Cadiz (Spain); Ben, Teresa; Molina, Sergio I. [Departamento de Ciencia de los Materiales e Ing. Metalurgica y Q. Inorganica, Facultad de Ciencias, Universidad de Cadiz, Pol. Rio San Pedro s/n. 11510, Puerto Real, Cadiz (Spain)

    2007-11-15

    Strain mapping is defined as a numerical image-processing technique that measures the local shifts of image details around a crystal defect with respect to the ideal, defect-free, positions in the bulk. Algorithms to map elastic strains from high-resolution transmission electron microscopy (HRTEM) images may be classified into two categories: those based on the detection of peaks of intensity in real space and the Geometric Phase approach, calculated in Fourier space. In this paper, we discuss both categories and propose an alternative real space algorithm (Peak Pairs) based on the detection of pairs of intensity maxima in an affine transformed space dependent on the reference area. In spite of the fact that it is a real space approach, the Peak Pairs algorithm exhibits good behaviour at heavily distorted defect cores, e.g. interfaces and dislocations. Quantitative results are reported from experiments to determine local strain in different types of semiconductor heterostructures.

  18. An internal friction peak caused by hydrogen in maraging steel

    International Nuclear Information System (INIS)

    Usui, Makoto; Asano, Shigeru

    1996-01-01

    Internal friction in hydrogen-charged iron and steel has so far been studied by a large number of investigators. For pure iron, a well-defined peak of internal friction has been observed under the cold-worked and hydrogen-charged conditions. This is called the hydrogen cold-work peak, or the Snoek-Koester relaxation, which originates from the hydrogen-dislocation interaction. In the present study, a high-strength maraging steel (Fe-18Ni-9Co-5Mo) was chosen as another high-alloy steel which is known to be very susceptible to hydrogen embrittlement. The purpose of this paper is to show a new internal friction peak caused by hydrogen in the maraging steel and to compare it with those found in stainless steels which have so far been studied as typical engineering high-alloy materials

  19. Gnevyshev peaks in solar radio emissions at different frequencies

    Directory of Open Access Journals (Sweden)

    R. P. Kane

    2009-04-01

    Full Text Available Sunspots have a major 11-year cycle, but the years near the sunspot maximum show two or more peaks called GP (Gnevyshev Peaks. In this communication, it was examined whether these peaks in sunspots are reflected in other parameters such as Lyman-α (the chromospheric emission 121.6 nm, radio emissions 242–15 400 MHz emanating from altitude levels 2000–12 000 km, the low latitude (+45° to −45° solar open magnetic flux and the coronal green line emission (Fe XIV, 530.3 nm. In the different solar cycles 20–23, the similarity extended at least upto the level of 609 MHz, but in cycle 22, the highest level was of 242 MHz. The extension to the higher level in cycle 22 does not seem to be related to the cycle strength Rz(max, or to the cycle length.

  20. COPAR: A ChIP-Seq Optimal Peak Analyzer.

    Science.gov (United States)

    Tang, Binhua; Wang, Xihan; Jin, Victor X

    2017-01-01

    Sequencing data quality and peak alignment efficiency of ChIP-sequencing profiles are directly related to the reliability and reproducibility of NGS experiments. Till now, there is no tool specifically designed for optimal peak alignment estimation and quality-related genomic feature extraction for ChIP-sequencing profiles. We developed open-sourced COPAR, a user-friendly package, to statistically investigate, quantify, and visualize the optimal peak alignment and inherent genomic features using ChIP-seq data from NGS experiments. It provides a versatile perspective for biologists to perform quality-check for high-throughput experiments and optimize their experiment design. The package COPAR can process mapped ChIP-seq read file in BED format and output statistically sound results for multiple high-throughput experiments. Together with three public ChIP-seq data sets verified with the developed package, we have deposited COPAR on GitHub under a GNU GPL license.

  1. High-Average, High-Peak Current Injector Design

    CERN Document Server

    Biedron, S G; Virgo, M

    2005-01-01

    There is increasing interest in high-average-power (>100 kW), um-range FELs. These machines require high peak current (~1 kA), modest transverse emittance, and beam energies of ~100 MeV. High average currents (~1 A) place additional constraints on the design of the injector. We present a design for an injector intended to produce the required peak currents at the injector, eliminating the need for magnetic compression within the linac. This reduces the potential for beam quality degradation due to CSR and space charge effects within magnetic chicanes.

  2. Simple Formula Relating Frequencies of Twin-peak Quasiperiodic Oscillations

    Science.gov (United States)

    Torok, Gabriel

    2017-08-01

    Twin-peak quasiperiodic oscillations are observed in several low-mass X-ray binary systems containing neutron stars. Timing analysis of X-ray fluxes of more than dozen of such systems reveals remarkable correlations between frequencies of two characteristic peaks present in the power density spectra. Several attempts to model these correlations with simple geodesic orbital models or phenomenological relations have failed in the past. We find and explore a surprisingly simple analytic formula that well reproduces individual correlations for a large group of sources. We also discuss possible theoretical interpretation of this formula.

  3. Universal parametric correlations of conductance peaks in quantum dots

    International Nuclear Information System (INIS)

    Alhassid, Y.; Attias, H.

    1996-01-01

    We compute the parametric correlation function of the conductance peaks in chaotic and weakly disordered quantum dots in the Coulomb blockade regime and demonstrate its universality upon an appropriate scaling of the parameter. For a symmetric dot we show that this correlation function is affected by breaking time-reversal symmetry but is independent of the details of the channels in the external leads. We derive a new scaling which depends on the eigenfunctions alone and can be extracted directly from the conductance peak heights. Our results are in excellent agreement with model simulations of a disordered quantum dot. copyright 1996 The American Physical Society

  4. Identification and separation of DNA mixtures using peak area information

    DEFF Research Database (Denmark)

    Cowell, R.G.; Lauritzen, Steffen Lilholt; Mortera, J.

    We show how probabilistic expert systems can be used to analyse forensic identification problems involving DNA mixture traces using quantitative peak area information. Peak area is modelled with conditional Gaussian distributions. The expert system can be used for scertaining whether individuals......, whose profiles have been measured, have contributed to the mixture, but also to predict DNA profiles of unknown contributors by separating the mixture into its individual components. The potential of our methodology is illustrated on case data examples and compared with alternative approaces...

  5. Quasispecies evolution on a fitness landscape with a fluctuating peak

    OpenAIRE

    Nilsson, Martin; Snoad, Nigel

    2000-01-01

    A quasispecies evolving on a fitness landscape with a single peak of fluctuating height is studied. In the approximation that back mutations can be ignored, the rate equations can be solved analytically. It is shown that the error threshold on this class of dynamic landscapes is defined by the time average of the selection pressure. In the case of a periodically fluctuating fitness peak we also study the phase-shift and response amplitude of the previously documented low-pass filter effect. T...

  6. Peak heart rate decreases with increasing severity of acute hypoxia

    DEFF Research Database (Denmark)

    Lundby, C; Araoz, M; Van Hall, Gerrit

    2001-01-01

    The purpose of the present study was to investigate the degree to which peak heart rate is reduced during exhaustive exercise in acute hypoxia. Five sea-level lowlanders performed maximal exercise at normobaric normoxia and at three different levels of hypobaric hypoxia (barometric pressures of 518......, 459, and 404 mmHg) in a hypobaric chamber and while breathing 9% O(2) in N(2). These conditions were equivalent to altitudes of 3300, 4300, 5300, and 6300 m above sea level, respectively. At 4300 m, maximal exercise was also repeated after 4 and 8 h. Peak heart rate (HR) decreased from 191 (182...

  7. Peak Oil and the Everyday Complexity of Human Progress Narratives

    Directory of Open Access Journals (Sweden)

    John C. Pruit

    2012-11-01

    Full Text Available The “big” story of human progress has polarizing tendencies featuring the binary options of progress or decline. I consider human progress narratives in the context of everyday life. Analysis of the “little” stories from two narrative environments focusing on peak oil offers a more complex picture of the meaning and contours of the narrative. I consider the impact of differential blog site commitments to peak oil perspectives and identify five narrative types culled from two narrative dimensions. I argue that the lived experience complicates human progress narratives, which is no longer an either/or proposition.

  8. Genetic and Dyanmic Analysis of Murine Peak Bone Density

    Science.gov (United States)

    1997-10-01

    years of age (1-3). As bone density decreases with age, the risk of osteoporotic fractures increases, especially when the density falls below the...fracture threshold. This relationship suggests that the risk of osteoporotic fracture can be defined in terms of two characteristics - the peak bone...two inbred strains of mice, C57BL/6J (B6) and C3H/HeJ (C3H), with highly significant differences in peak BMD in vertebrae (12%), tibia (20%), and

  9. Peak metamorphic temperatures from cation diffusion zoning in garnet

    DEFF Research Database (Denmark)

    Smit, Matthijs Arjen; Scherer, Erik; Mezger, Klaus

    2013-01-01

    is robust and provides a reliable means of estimating peak temperatures for different types of high-grade metamorphic rock. The tool could be of particular advantage in rocks where critical assemblages for conventional thermometry do not occur or have been replaced during retrogression.......) to develop a tool that uses the diffusion zoning of these cations in garnet to constrain peak temperature conditions for garnet-bearing rocks. The thermometric approach was externally tested by applying it to garnet crystals from various metamorphic terranes worldwide and comparing the results to published...

  10. Examining Engineering & Technology Students' Acceptance of Network Virtualization Technology Using the Technology Acceptance Model

    Science.gov (United States)

    Yousif, Wael K.

    2010-01-01

    This causal and correlational study was designed to extend the Technology Acceptance Model (TAM) and to test its applicability to Valencia Community College (VCC) Engineering and Technology students as the target user group when investigating the factors influencing their decision to adopt and to utilize VMware as the target technology. In…

  11. Mobile Health Technology Can Objectively Capture Physical Activity (PA) Targets Among African-American Women Within Resource-Limited Communities-the Washington, D.C. Cardiovascular Health and Needs Assessment.

    Science.gov (United States)

    Thomas, S; Yingling, L; Adu-Brimpong, J; Mitchell, V; Ayers, C R; Wallen, G R; Peters-Lawrence, M; Brooks, A T; Sampson, D M; Wiley, K L; Saygbe, J; Henry, J; Johnson, A; Graham, A; Graham, L; Powell-Wiley, T M

    2016-12-02

    Little is understood about using mobile health (mHealth) technology to improve cardiovascular (CV) health among African-American women in resource-limited communities. We conducted the Washington, D.C. CV Health and Needs Assessment in predominantly African-American churches in city wards 5, 7, and 8 with the lowest socioeconomic status based on community-based participatory research (CBPR) principles. The assessment measured CV health factors: body mass index (BMI), fasting blood glucose and cholesterol, blood pressure, fruit/vegetable (F/V) intake, physical activity (PA), and smoking. Participants were trained to use a PA monitoring wristband to measure 30 days of PA, wirelessly upload the PA data to hubs at the participating churches, and access their data from a church/home computer. CV health factors were compared across weight classes. Among females (N = 78; 99 % African-American; mean age = 59 years), 90 % had a BMI categorized as overweight/obese. Across weight classes, PA decreased and self-reported sedentary time (ST) increased (p ≤ 0.05). Diastolic blood pressure and glucose increased across weight classes (p ≤ 0.05); however, cholesterol, glucose, and BP were near intermediate CV health goals. Decreased PA and increased ST are potential community intervention targets for overweight and obese African-American women in resource-limited Washington D.C. areas. mHealth technology can assist in adapting CBPR intervention resources to improve PA for African-American women in resource-limited communities.

  12. Emerging Technologies for Telemedicine

    Science.gov (United States)

    Minh, Cao Duc; Antoku, Yasuaki; Torata, Nobuhiro; Kudo, Kuriko; Okamura, Koji; Nakashima, Naoki; Tanaka, Masao

    2012-01-01

    This paper focuses on new technologies that are practically useful for telemedicine. Three representative systems are introduced: a Digital Video Transport System (DVTS), an H.323 compatible videoconferencing system, and Vidyo. Based on some of our experiences, we highlight the advantages and disadvantages of each technology, and point out technologies that are especially targeted at doctors and technicians, so that those interested in using similar technologies can make appropriate choices and achieve their own goals depending on their specific conditions. PMID:22563284

  13. flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding

    Science.gov (United States)

    Ge, Yongchao; Sealfon, Stuart C.

    2012-01-01

    Motivation: For flow cytometry data, there are two common approaches to the unsupervised clustering problem: one is based on the finite mixture model and the other on spatial exploration of the histograms. The former is computationally slow and has difficulty to identify clusters of irregular shapes. The latter approach cannot be applied directly to high-dimensional data as the computational time and memory become unmanageable and the estimated histogram is unreliable. An algorithm without these two problems would be very useful. Results: In this article, we combine ideas from the finite mixture model and histogram spatial exploration. This new algorithm, which we call flowPeaks, can be applied directly to high-dimensional data and identify irregular shape clusters. The algorithm first uses K-means algorithm with a large K to partition the cell population into many small clusters. These partitioned data allow the generation of a smoothed density function using the finite mixture model. All local peaks are exhaustively searched by exploring the density function and the cells are clustered by the associated local peak. The algorithm flowPeaks is automatic, fast and reliable and robust to cluster shape and outliers. This algorithm has been applied to flow cytometry data and it has been compared with state of the art algorithms, including Misty Mountain, FLOCK, flowMeans, flowMerge and FLAME. Availability: The R package flowPeaks is available at https://github.com/yongchao/flowPeaks. Contact: yongchao.ge@mssm.edu Supplementary information: Supplementary data are available at Bioinformatics online PMID:22595209

  14. Variant formula for predicting peak expiratory flow rate in pregnant ...

    African Journals Online (AJOL)

    Observed Peak expiratory flow rate (PEFR), Predicted and Variant PEFR values in 123 females at their reproductive ages, living in Kura local government area of Kano State, Nigeria and its environs were obtained. The prediction and variant formulae used were; PEFR= 0.36AGE – 0.47WT + 391.67 and K = mean CC x ...

  15. Characteristics of peaks of inhalation exposure to organic solvents

    NARCIS (Netherlands)

    Preller, L.; Burstyn, I.; Pater, N. de; Kromhout, H.

    2004-01-01

    Objectives: To determine which exposure metrics are sufficient to characterize 'peak' inhalation exposure to organic solvents (OS) during spraying operations. Methods: Personal exposure measurements (n = 27; duration 5-159 min) were collected during application of paints, primers, resins and glues

  16. A new sample of faint Gigahertz Peaked Spectrum radio sources

    NARCIS (Netherlands)

    Snellen, IAG; Schilizzi, RT; de Bruyn, AG; Miley, GK; Rengelink, RB; Rottgering, HJ

    The Westerbork Northern Sky Survey (WENSS) has been used to select a sample of Gigahertz Peaked Spectrum (GPS) radio sources at flux densities one to two orders of magnitude lower than bright GPS sources investigated in earlier studies. Sources with inverted spectra at frequencies above 325 MHz have

  17. PEAK EXPIRATORY FLOW AS A SURROGATE FOR HEALTH ...

    African Journals Online (AJOL)

    2014-06-01

    Jun 1, 2014 ... Proportions reported are based on the entire sample of patients. Sixty five percent of the patients had peak flow read- ings below the acceptable lower limit of normal (LLN) for their age and height (Table 2). The mean (SD) of predicted post bronchodilator (post BD) PEF, FEV1,. FVC and FEV1/FVC were ...

  18. East ad Central African Journal of Pharmaceutical Sciences Peak ...

    African Journals Online (AJOL)

    chromatographic peak purity. This is attributed to the capacity of the linear photodiode arrays to collect spectro-chromatographic data in the absorbance (A), wavelength (A) and time (t) matrix. Such instruments have in-built routine software that is easy to apply during post collection data manipulations. Examples of such.

  19. Scheduling Non-Preemptible Jobs to Minimize Peak Demand

    Directory of Open Access Journals (Sweden)

    Sean Yaw

    2017-10-01

    Full Text Available This paper examines an important problem in smart grid energy scheduling; peaks in power demand are proportionally more expensive to generate and provision for. The issue is exacerbated in local microgrids that do not benefit from the aggregate smoothing experienced by large grids. Demand-side scheduling can reduce these peaks by taking advantage of the fact that there is often flexibility in job start times. We focus attention on the case where the jobs are non-preemptible, meaning once started, they run to completion. The associated optimization problem is called the peak demand minimization problem, and has been previously shown to be NP-hard. Our results include an optimal fixed-parameter tractable algorithm, a polynomial-time approximation algorithm, as well as an effective heuristic that can also be used in an online setting of the problem. Simulation results show that these methods can reduce peak demand by up to 50% versus on-demand scheduling for household power jobs.

  20. Infrared Peak Splitting from Phonon Localization in Solid Hydrogen.

    Science.gov (United States)

    Magdău, Ioan B; Ackland, Graeme J

    2017-04-07

    We show that the isotope effect leads to a completely different spectroscopic signal in hydrogen-deuterium mixtures, compared to pure elements that have the same crystal structure. This is particularly true for molecular vibrations, which are the main source of information about the structure of high-pressure hydrogen. Mass disorder breaks translational symmetry, meaning that vibrations are localized almost to single molecules, and are not zone-center phonons. In mixtures, each observable infrared (IR) peak corresponds to a collection of many such molecular vibrations, which have a distribution of frequencies depending on local environment. Furthermore discrete groups of environments cause the peaks to split. We illustrate this issue by considering the IR spectrum of the high-pressure phase III structure of hydrogen, recently interpreted as showing novel phases in isotopic mixtures. We calculate the IR spectrum of hydrogen-deuterium mixtures in the C2/c and Cmca-12 structures, showing that isotopic disorder gives rise to mode localization of the high-frequency vibrons. The local coordination of the molecules leads to discrete IR peaks. The spread of frequencies is strongly enhanced with pressure, such that more peaks become resolvable at higher pressures, in agreement with the recent measurements.

  1. Measurement of peak temperature along an optical fiber

    International Nuclear Information System (INIS)

    Fox, R.J.

    1983-01-01

    A multimode silica-clad optical fiber with a liquid silicone core was used as a distributed-line peak-temperature sensor over a temperature range from ambient to 190 0 C. The maximum error was 2 0 C and was essentially independent of the length or position of the hot zone

  2. Biomechanical aspects of peak performance in human swimming

    NARCIS (Netherlands)

    Toussaint, H.M.; Truijens, M.J.

    2005-01-01

    Peak performances in sport require the full deployment of all the powers an athlete possesses. How factors such as mechanical power output, technique and drag, each individually, but also in concert, determine swimming performance is the subject of this enquiry. This overview of swimming

  3. Pikes Peak conceptual shuttle study : visitation trends and scenario planning

    Science.gov (United States)

    2016-04-01

    This study for the U.S. Forest Service provides a preliminary analysis and set of recommendations to support the agency's work moving forward to implement a shuttle system at Colorados popular Pikes Peak in Pike and San Isabel National Forests. Th...

  4. Blue Ice Tephra II - Brimstone Peak, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set is the result of a study of volcanic ash and rock fragment (tephra) layers in exposed blue ice areas on Brimstone Peak (75.888S 158.55E) in East...

  5. Peak effect at microwave frequencies in swift heavy ion irradiated ...

    Indian Academy of Sciences (India)

    few tens of Hz to a few MHz, probing the dynamics of the FLL revealed no frequency dependence of the peak position of the PE which is suggestive of a true thermodynamic phase transition. Studies of the vortex dynamics carried out at microwave and radio fre- quencies in low Tc and high Tc superconductors, do not report ...

  6. Focal F0 peak shape and sentence mode in Swedish

    DEFF Research Database (Denmark)

    Ambrazaitis, Gilbert; Buanzur, Tuarik C.; Niebuhr, Oliver

    2015-01-01

    Shape characteristics of rising-falling accentual F0 peaks of Stockholm Swedish Accent I words in narrow focus are studied in a corpus of 287 read sentences. The corpus includes statements and three types of polar questions. Results reveal a clear effect of sentence mode on the shape of the accen...

  7. High precision 16K, 16 channel peak sensing CAMAC ADC

    International Nuclear Information System (INIS)

    Jain, Mamta; Subramaniam, E.T

    2013-01-01

    A high density, peak sensing, analog to digital converter (ADC) double width module with CAMAC back plane has been developed for nuclear physics experiments with a large number of detectors. This module has sixteen independent channels in plug-in daughter card mother board mode

  8. Standardization of I-125. Sum-Peak Coincidence Counting

    International Nuclear Information System (INIS)

    Grau Carles, A.; Grau Malonda, A.

    2011-01-01

    I-125 is a nuclide which presents difficulties for standardization. The sum-peak method is one of the procedures used to standardize this radionuclide. Initially NaI (Tl)detectors and then the semiconductor detectors with higher resolution have been used.This paper describes the different methods based on the sum-peak procedure and the different expressions used to calculate the activity are deduced. We describe a general procedure for obtaining all of the above equations and many more. We analyze the influence of uncertainties in the used parameters in the uncertainty of the activity. We give a complete example of the transmission of uncertainty and the effects of correlations in the uncertainty of the activity of the sample. High-resolution spectra show an unresolved doublet of 62.0 keV and 62.8 keV. The paper presents two approaches to solve this problem. One is based on the calculation of area ratio and the sum of peak areas obtained from atomic and nuclear data, in the other we modify the equations so that the sum of the peak areas doublet, rather than its components, is present. (Author) 19 refs.

  9. Standardization of I-125. Sum-Peak Coincidence Counting

    Energy Technology Data Exchange (ETDEWEB)

    Grau Carles, A.; Grau Malonda, A.

    2011-07-01

    I-125 is a nuclide which presents difficulties for standardization. The sum-peak method is one of the procedures used to standardize this radionuclide. Initially NaI (Tl)detectors and then the semiconductor detectors with higher resolution have been used.This paper describes the different methods based on the sum-peak procedure and the different expressions used to calculate the activity are deduced. We describe a general procedure for obtaining all of the above equations and many more. We analyze the influence of uncertainties in the used parameters in the uncertainty of the activity. We give a complete example of the transmission of uncertainty and the effects of correlations in the uncertainty of the activity of the sample. High-resolution spectra show an unresolved doublet of 62.0 keV and 62.8 keV. The paper presents two approaches to solve this problem. One is based on the calculation of area ratio and the sum of peak areas obtained from atomic and nuclear data, in the other we modify the equations so that the sum of the peak areas doublet, rather than its components, is present. (Author) 19 refs.

  10. Robust peak-shaving for a neighborhood with electric vehicles

    NARCIS (Netherlands)

    Gerards, Marco Egbertus Theodorus; Hurink, Johann L.

    2016-01-01

    Demand Side Management (DSM) is a popular approach for grid-aware peak-shaving. The most commonly used DSM methods either have no look ahead feature and risk deploying flexibility too early, or they plan ahead using predictions, which are in general not very reliable. To counter this, a DSM approach

  11. Do leading indicators lead peaks more than troughs?

    NARCIS (Netherlands)

    R. Paap (Richard); R. Segers (René); D.J.C. van Dijk (Dick)

    2007-01-01

    textabstractWe develop a formal statistical approach to investigate the possibility that leading indicator variables have different lead times at business cycle peaks and troughs. For this purpose, we propose a novel Markov switching vector autoregressive model, where economic growth and leading

  12. quasi hyperrigidity and weak peak points for non-commutative ...

    Indian Academy of Sciences (India)

    7

    sentation. Several examples are provided to illustrate these notions. 1. Introduction. The concepts of peak point and Choquet boundary play an important role in several areas of classical (commutative) analysis. To be more precise the idea was to identify optimal subsets of a compact Hausdorff space X such that each and.

  13. Anatomy of simultaneous flood peaks at a lowland confluence

    Science.gov (United States)

    Hoitink, T.; Geertsema, T.; Teuling, R.; Uijlenhoet, R.; Torfs, P. J.; Weerts, A.

    2017-12-01

    Lowlands are vulnerable to flooding due to their mild topography in often densely populated areas with high social and economic value. Moreover, multiple physical processes coincide in lowland areas, such as those involved in river-sea interactions and in merging of rivers. Simultaneous occurrence of such processes can result in amplifying or attenuating effects on water levels. Our aim is to understand the mechanisms behind simultaneous occurrence of discharge waves in a river and its lowland tributaries, taking the confluence of the Meuse river with the joining tributaries of the Dommel and Aa as an example. Especially since the January 1995 flood at this confluence is the result of the simultaneous occurrence of discharge peaks in the main stream and the tributaries. Here, we introduce a new way of analyzing lowland discharge and water level dynamics, by tracing individual flood waves based on dynamic time warping. The analysis shows that the exact timing of the arrival of discharge peaks is little relevant, because of the long duration of a discharge wave compared to the time lags between peaks. The discharge waves last on average 9 days, whereas the typical lag time between discharge peaks in the main river and the tributaries is 3 days. Flood water levels are insensitive to the ongoing measures of water retention in the tributary catchment despite the backwaters that can rise up to 1.5 m over a distance of 4 km from the confluence.

  14. predicted peak expiratory flow in human and the clinical implication ...

    African Journals Online (AJOL)

    DR. AMINU

    values using formula developed by (Gregg, 1973) at 50th percentile for age, height and weight obtained from our study (Salisu ... Keywords: Peak expiratory flow, Asthma, Practice guidelines, reference values. INTRODUCTION. The National ... that the personal best PEF may be estimated after a. 2-to-3-week period in which ...

  15. Peak expiratory flow rate and respiratory symptoms following ...

    African Journals Online (AJOL)

    Peak expiratory flow rate (PEFR) of 350 rural women aged (20-70 years) in Edo State, Nigeria who actively used wood as a source of fuel for cooking was measured. The height, chest circumference, weight and blood pressure of the women were also measured. Respiratory symptoms of cough with sputum production, ...

  16. Simple area determination of strongly overlapping ion mobility peaks

    Czech Academy of Sciences Publication Activity Database

    Borovcová, L.; Hermannová, M.; Pauk, V.; Šimek, M.; Havlíček, Vladimír; Lemr, Karel

    2017-01-01

    Roč. 981, AUG 15 (2017), s. 71-79 ISSN 0003-2670 Grant - others:GA MŠk(CZ) LO1305 Institutional support: RVO:61388971 Keywords : Ion mobility-mass spectrometry * Fitting of mobility peaks * Analysis of isomers Subject RIV: CB - Analytical Chemistry, Separation OBOR OECD: Analytical chemistry Impact factor: 4.950, year: 2016

  17. Analysis of multibeam-hydrosweep echo peaks for seabed characterisation

    Digital Repository Service at National Institute of Oceanography (India)

    Chakraborty, B.; Schenke, H.W.; Kodagali, V.N.; Hagen, R.

    , in general, Gaussian in nature except in the case of the Kainan Maru seamount summit (area D). The outer beams of the Enderby abyssal plain (area C) echo-peak PDF statistics reveal the highest possible large-scale feature dominance. Interestingly, Extremal...

  18. Rare terrestrial orchids on Mbeya Peak, Southern Tanzania | van ...

    African Journals Online (AJOL)

    Disa walteri, Satyrium aberrans, S. comptum and S. johnsonii are rare terrestrial orchids that co-occur and flower around the same time in southern Tanzania. We found the first three of these species on Mbeya Peak in March 2005, about 45 years after they were last recorded by botanists and present the first illustration of D.

  19. Statistical agglomeration: peak summarization for direct infusion lipidomics.

    Science.gov (United States)

    Smith, Rob; Anthonymuthu, Tamil S; Ventura, Dan; Prince, John T

    2013-10-01

    Quantification of lipids is a primary goal in lipidomics. In direct infusion/injection (or shotgun) lipidomics, accurate downstream identification and quantitation requires accurate summarization of repetitive peak measurements. Imprecise peak summarization multiplies downstream error by propagating into species identification and intensity estimation. To our knowledge, this is the first analysis of direct infusion peak summarization in the literature. We present two novel peak summarization algorithms for direct infusion samples and compare them with an off-machine ad hoc summarization algorithm as well as with the propriety Xcalibur algorithm. Our statistical agglomeration algorithm reduces peakwise error by 38% mass/charge (m/z) and 44% (intensity) compared with the ad hoc method over three datasets. Pointwise error is reduced by 23% (m/z). Compared with Xcalibur, our statistical agglomeration algorithm produces 68% less m/z error and 51% less intensity error on average on two comparable datasets. The source code for Statistical Agglomeration and the datasets used are freely available for non-commercial purposes at https://github.com/optimusmoose/statistical_agglomeration. Modified Bin Aggolmeration is freely available in MSpire, an open source mass spectrometry package at https://github.com/princelab/mspire/.

  20. Bragg peak and relative biological efficiency of different ions

    Czech Academy of Sciences Publication Activity Database

    Lokajíček st., Miloš; Judas, Libor; Kundrát, Pavel

    2002-01-01

    Roč. 64, Suppl. 1 (2002), S309-S309 ISSN 0167-8140 R&D Projects: GA AV ČR(CZ) KSK4055109 Keywords : Bragg peak * relative biological efficisncy * radiological mechanism Subject RIV: CC - Organic Chemistry Impact factor: 2.838, year: 2002

  1. Factors influencing peak expiratory flow in teenage boys | van ...

    African Journals Online (AJOL)

    Background. Peak expiratory flow (PEF) is a useful measure of pulmonary health status and is frequently utilised in asthm, management. Reduction in PEF is usually indicative of OIlS( of asthma symptoms. However, use can be made of PEF values only if normal values are known. The definition of normal range is always ...

  2. Analytical construction of peaked solutions for the nonlinear ...

    African Journals Online (AJOL)

    These results demonstrate the existence of peaked pulses propagating through a pair plasma. The algebraic decay rate of the pulses are determined analytically, as well. The method discussed here can be applied to approximate solutions to similar nonlinear partial differential equations of nonlinear Schrödinger type.

  3. Energy and Public Health: The Challenge of Peak Petroleum

    OpenAIRE

    Frumkin, Howard; Hess, Jeremy; Vindigni, Stephen

    2009-01-01

    Petroleum is a unique and essential energy source, used as the principal fuel for transportation, in producing many chemicals, and for numerous other purposes. Global petroleum production is expected to reach a maximum in the near future and to decline thereafter, a phenomenon known as “peak petroleum.”

  4. Daily peak electricity load forecasting in South Africa using a ...

    African Journals Online (AJOL)

    A multivariate adaptive regression splines (MARS) modelling approach towards daily peak electricity load forecasting in South Africa is presented in this paper for the period 2000 to 2009. MARS is a non-parametric multivariate regression method which is used in high-dimensional problems with complex model structures, ...

  5. Effect of Gymnema inodorum on postprandial peak plasma glucose ...

    African Journals Online (AJOL)

    Gymnema inodorum (GI), a vegetable widely used in a Northern Thai food, is known for not only its health nourishing effect, but also its hypoglycemic effect. But no scientific evidence on the hypoglycemic effect of GI has ever been reported in human. In this study, the effect of GI consumption on peak plasma glucose ...

  6. Daily peak electricity load forecasting in South Africa using a ...

    African Journals Online (AJOL)

    transmission substations, scheduling of startup times of peak stations, load flow analysis and power system security ... blackout. This NESO definition excludes the demand from people, companies, etc. who are willing (or unwilling) and able (or unable) to pay for electricity, but currently do not have access to electrical power.

  7. Radio spectra of Gigahertz Peaked Spectrum radio sources

    NARCIS (Netherlands)

    deVries, WH; Barthel, PD; ODea, CP

    A well defined sample of 72 Gigahertz Peaked Spectrum radio sources is compiled, having turnover frequencies in the range of 0.5 - 10 GHz. Using this sample, the canonical GPS radio spectrum is constructed, which is found to have a constant shape, independent of AGN type, redshift or radio

  8. Algorithm for systematic peak extraction from atomic pair distribution functions.

    Science.gov (United States)

    Granlund, L; Billinge, S J L; Duxbury, P M

    2015-07-01

    The study presents an algorithm, ParSCAPE, for model-independent extraction of peak positions and intensities from atomic pair distribution functions (PDFs). It provides a statistically motivated method for determining parsimony of extracted peak models using the information-theoretic Akaike information criterion (AIC) applied to plausible models generated within an iterative framework of clustering and chi-square fitting. All parameters the algorithm uses are in principle known or estimable from experiment, though careful judgment must be applied when estimating the PDF baseline of nanostructured materials. ParSCAPE has been implemented in the Python program SrMise. Algorithm performance is examined on synchrotron X-ray PDFs of 16 bulk crystals and two nanoparticles using AIC-based multimodeling techniques, and particularly the impact of experimental uncertainties on extracted models. It is quite resistant to misidentification of spurious peaks coming from noise and termination effects, even in the absence of a constraining structural model. Structure solution from automatically extracted peaks using the Liga algorithm is demonstrated for 14 crystals and for C60. Special attention is given to the information content of the PDF, theory and practice of the AIC, as well as the algorithm's limitations.

  9. Peak Expiratory Flow Rate in Petroleum Depot Workers and Petrol ...

    African Journals Online (AJOL)

    Peak Expiratory Flow Rate (PEFR) values in litres per minute were determined in petrol depot loaders, petrol station attendants and in control subjects. The PEFR values were 315 ± 94, 386 + 91 and 529 + 94 litres/min. in depot workers, petrol attendants and control subjects respectively. The value in the control subjects ...

  10. Monsoon onset over Kerala and pre monsoon rainfall peak

    Digital Repository Service at National Institute of Oceanography (India)

    RameshKumar, M.R.; Shenoi, S.S.C.; Shankar, D.

    degrees E, from 1st March to 31 May for the years 1979 to 2001. The monsoon onset dates over Kerala, as declared by India Meteorological Department has been used in the present study. For each year, the midday of the pentad with the rainfall peak...

  11. Size-independent peak shift between normal and upconversion ...

    Indian Academy of Sciences (India)

    2014-02-12

    Feb 12, 2014 ... In this article, we report size-dependent measurement of the shift in peak of upconversion photoluminescence spectra compared to that of normal photoluminescence using a 800 nm femtosecond laser and its second harmonic. It has been shown that the upconversion photoluminescence is always ...

  12. Optical spectroscopy of faint gigahertz peaked-spectrum sources

    NARCIS (Netherlands)

    Snellen, IAG; Schilizzi, RT; Miley, GK; de Bruyn, AG; Rottgering, HJA

    1999-01-01

    We present spectroscopic observations of a sample of faint gigahertz peaked-spectrum (GPS) radio sources drawn from the Westerbork Northern Sky Survey (WENSS), Redshifts have been determined for 19 (40 per cent) of the objects. The optical spectra of the GPS sources identified with low-redshift

  13. On the asymptotic behavior of flood peak distributions

    Directory of Open Access Journals (Sweden)

    E. Gaume

    2006-01-01

    Full Text Available This paper presents some analytical results and numerical illustrations on the asymptotic properties of flood peak distributions obtained through derived flood frequency approaches. It confirms and extends the results of previous works: i.e. the shape of the flood peak distributions are asymptotically controlled by the rainfall statistical properties, given limited and reasonable assumptions concerning the rainfall-runoff process. This result is partial so far: the impact of the rainfall spatial heterogeneity has not been studied for instance. From a practical point of view, it provides a general framework for analysis of the outcomes of previous works based on derived flood frequency approaches and leads to some proposals for the estimation of very large return-period flood quantiles. This paper, focussed on asymptotic distribution properties, does not propose any new approach for the extrapolation of flood frequency distribution to estimate intermediate return period flood quantiles. Nevertheless, the large distance between frequent flood peak values and the asymptotic values as well as the simulations conducted in this paper help quantifying the ill condition of the problem of flood frequency distribution extrapolation: it illustrates how large the range of possibilities for the shapes of flood peak distributions is.

  14. T(peak)T(end) interval in long QT syndrome

    DEFF Research Database (Denmark)

    Kanters, Jørgen Kim; Haarmark, Christian; Vedel-Larsen, Esben

    2008-01-01

    BACKGROUND: The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related...

  15. Size-independent peak shift between normal and upconversion ...

    Indian Academy of Sciences (India)

    2014-02-12

    Feb 12, 2014 ... Abstract. In this article, we report size-dependent measurement of the shift in peak of upcon- version photoluminescence spectra compared to that of normal photoluminescence using a 800 nm femtosecond laser and its second harmonic. It has been shown that the upconversion photolumi- nescence is ...

  16. variant formula for predicting peak expiratory flow rate in pregnant ...

    African Journals Online (AJOL)

    DR. AMINU

    The graph illustrates close association of variant formula with the observed values of PEFR obtained from the study. Variant formula may be useful in clinical setting to assess people with respiratory disorders especially asthma. Key words: Variant formula, Peak expiratory flow rate, Pregnancy, Kura local government area.

  17. Changes in Peak Expiratory Flow Rate, Blood Pressure and Pulse ...

    African Journals Online (AJOL)

    We studied the effect of different concentrations of coffee on peak expiratory flow rate (PEFR), blood pressure and pulse rate in an attempt to determine some physiological effects of coffee intake. 18 apparently healthy adult males, age range 20 to 30 years, were recruited for the study over a three day period. Varying ...

  18. Fueling growth when oil peaks : Directed technological change and the limits to efficiency

    NARCIS (Netherlands)

    Andre, F.J.; Smulders, Sjak A.

    While fossil energy dependency has declined and energy supply has grown in the postwar world economy, future resource scarcity could cast its shadow on world economic growth soon if energy markets are forward looking. We develop an endogenous growth model that reconciles the current aggregate trends

  19. Automatic Locking of Laser Frequency to an Absorption Peak

    Science.gov (United States)

    Koch, Grady J.

    2006-01-01

    An electronic system adjusts the frequency of a tunable laser, eventually locking the frequency to a peak in the optical absorption spectrum of a gas (or of a Fabry-Perot cavity that has an absorption peak like that of a gas). This system was developed to enable precise locking of the frequency of a laser used in differential absorption LIDAR measurements of trace atmospheric gases. This system also has great commercial potential as a prototype of means for precise control of frequencies of lasers in future dense wavelength-division-multiplexing optical communications systems. The operation of this system is completely automatic: Unlike in the operation of some prior laser-frequency-locking systems, there is ordinarily no need for a human operator to adjust the frequency manually to an initial value close enough to the peak to enable automatic locking to take over. Instead, this system also automatically performs the initial adjustment. The system (see Figure 1) is based on a concept of (1) initially modulating the laser frequency to sweep it through a spectral range that includes the desired absorption peak, (2) determining the derivative of the absorption peak with respect to the laser frequency for use as an error signal, (3) identifying the desired frequency [at the very top (which is also the middle) of the peak] as the frequency where the derivative goes to zero, and (4) thereafter keeping the frequency within a locking range and adjusting the frequency as needed to keep the derivative (the error signal) as close as possible to zero. More specifically, the system utilizes the fact that in addition to a zero crossing at the top of the absorption peak, the error signal also closely approximates a straight line in the vicinity of the zero crossing (see Figure 2). This vicinity is the locking range because the linearity of the error signal in this range makes it useful as a source of feedback for a proportional + integral + derivative control scheme that

  20. Peak Dose Assessment for Proposed DOE-PPPO Authorized Limits

    Energy Technology Data Exchange (ETDEWEB)

    Maldonado, Delis [Oak Ridge Institute for Science and Education, Oak Ridge, TN (United States). Independent Environmental Assessment and Verification Program

    2012-06-01

    The Oak Ridge Institute for Science and Education (ORISE), a U.S. Department of Energy (DOE) prime contractor, was contracted by the DOE Portsmouth/Paducah Project Office (DOE-PPPO) to conduct a peak dose assessment in support of the Authorized Limits Request for Solid Waste Disposal at Landfill C-746-U at the Paducah Gaseous Diffusion Plant (DOE-PPPO 2011a). The peak doses were calculated based on the DOE-PPPO Proposed Single Radionuclides Soil Guidelines and the DOE-PPPO Proposed Authorized Limits (AL) Volumetric Concentrations available in DOE-PPPO 2011a. This work is provided as an appendix to the Dose Modeling Evaluations and Technical Support Document for the Authorized Limits Request for the C-746-U Landfill at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky (ORISE 2012). The receptors evaluated in ORISE 2012 were selected by the DOE-PPPO for the additional peak dose evaluations. These receptors included a Landfill Worker, Trespasser, Resident Farmer (onsite), Resident Gardener, Recreational User, Outdoor Worker and an Offsite Resident Farmer. The RESRAD (Version 6.5) and RESRAD-OFFSITE (Version 2.5) computer codes were used for the peak dose assessments. Deterministic peak dose assessments were performed for all the receptors and a probabilistic dose assessment was performed only for the Offsite Resident Farmer at the request of the DOE-PPPO. In a deterministic analysis, a single input value results in a single output value. In other words, a deterministic analysis uses single parameter values for every variable in the code. By contrast, a probabilistic approach assigns parameter ranges to certain variables, and the code randomly selects the values for each variable from the parameter range each time it calculates the dose (NRC 2006). The receptor scenarios, computer codes and parameter input files were previously used in ORISE 2012. A few modifications were made to the parameter input files as appropriate for this effort. Some of these changes

  1. Peak Dose Assessment for Proposed DOE-PPPO Authorized Limits

    International Nuclear Information System (INIS)

    Maldonado, Delis

    2012-01-01

    The Oak Ridge Institute for Science and Education (ORISE), a U.S. Department of Energy (DOE) prime contractor, was contracted by the DOE Portsmouth/Paducah Project Office (DOE-PPPO) to conduct a peak dose assessment in support of the Authorized Limits Request for Solid Waste Disposal at Landfill C-746-U at the Paducah Gaseous Diffusion Plant (DOE-PPPO 2011a). The peak doses were calculated based on the DOE-PPPO Proposed Single Radionuclides Soil Guidelines and the DOE-PPPO Proposed Authorized Limits (AL) Volumetric Concentrations available in DOE-PPPO 2011a. This work is provided as an appendix to the Dose Modeling Evaluations and Technical Support Document for the Authorized Limits Request for the C-746-U Landfill at the Paducah Gaseous Diffusion Plant, Paducah, Kentucky (ORISE 2012). The receptors evaluated in ORISE 2012 were selected by the DOE-PPPO for the additional peak dose evaluations. These receptors included a Landfill Worker, Trespasser, Resident Farmer (onsite), Resident Gardener, Recreational User, Outdoor Worker and an Offsite Resident Farmer. The RESRAD (Version 6.5) and RESRAD-OFFSITE (Version 2.5) computer codes were used for the peak dose assessments. Deterministic peak dose assessments were performed for all the receptors and a probabilistic dose assessment was performed only for the Offsite Resident Farmer at the request of the DOE-PPPO. In a deterministic analysis, a single input value results in a single output value. In other words, a deterministic analysis uses single parameter values for every variable in the code. By contrast, a probabilistic approach assigns parameter ranges to certain variables, and the code randomly selects the values for each variable from the parameter range each time it calculates the dose (NRC 2006). The receptor scenarios, computer codes and parameter input files were previously used in ORISE 2012. A few modifications were made to the parameter input files as appropriate for this effort. Some of these changes

  2. Delay-induced rebounds in CO2 emissions and critical time-scales to meet global warming targets

    Science.gov (United States)

    Manoli, Gabriele; Katul, Gabriel G.; Marani, Marco

    2016-12-01

    While climate science debates are focused on the attainment of peak anthropogenic CO2 emissions and policy tools to reduce peak temperatures, the human-energy-climate system can hold "rebound" surprises beyond this peak. Following the second industrial revolution, global per capita CO2 emissions (cc) experienced a punctuated growth of about 100% every 60 years, mainly attributable to technological development and its global spread. A model of the human-energy-climate system capable of reproducing past punctuated dynamics shows that rebounds in global CO2 emissions emerge due to delays intrinsic to the diffusion of innovations. Such intrinsic delays in the adoption and spread of low-carbon emitting technologies, together with projected population growth, upset the warming target set by the Paris Agreement. To avoid rebounds and their negative climate effects, model calculations show that the diffusion of climate-friendly technologies must occur with lags one-order of magnitude shorter (i.e., ˜6 years) than the characteristic timescale of past punctuated growth in cc. Radically new strategies to globally implement the technological advances at unprecedented rates are needed if the current emission goals are to be achieved.

  3. Peak Running Intensity of International Rugby: Implications for Training Prescription.

    Science.gov (United States)

    Delaney, Jace A; Thornton, Heidi R; Pryor, John F; Stewart, Andrew M; Dascombe, Ben J; Duthie, Grant M

    2017-09-01

    To quantify the duration and position-specific peak running intensities of international rugby union for the prescription and monitoring of specific training methodologies. Global positioning systems (GPS) were used to assess the activity profile of 67 elite-level rugby union players from 2 nations across 33 international matches. A moving-average approach was used to identify the peak relative distance (m/min), average acceleration/deceleration (AveAcc; m/s 2 ), and average metabolic power (P met ) for a range of durations (1-10 min). Differences between positions and durations were described using a magnitude-based network. Peak running intensity increased as the length of the moving average decreased. There were likely small to moderate increases in relative distance and AveAcc for outside backs, halfbacks, and loose forwards compared with the tight 5 group across all moving-average durations (effect size [ES] = 0.27-1.00). P met demands were at least likely greater for outside backs and halfbacks than for the tight 5 (ES = 0.86-0.99). Halfbacks demonstrated the greatest relative distance and P met outputs but were similar to outside backs and loose forwards in AveAcc demands. The current study has presented a framework to describe the peak running intensities achieved during international rugby competition by position, which are considerably higher than previously reported whole-period averages. These data provide further knowledge of the peak activity profiles of international rugby competition, and this information can be used to assist coaches and practitioners in adequately preparing athletes for the most demanding periods of play.

  4. Peak-locking reduction for particle image velocimetry

    International Nuclear Information System (INIS)

    Michaelis, Dirk; Wieneke, Bernhard; Neal, Douglas R

    2016-01-01

    A parametric study of the factors contributing to peak-locking, a known bias error source in particle image velocimetry (PIV), is conducted using synthetic data that are processed with a state-of-the-art PIV algorithm. The investigated parameters include: particle image diameter, image interpolation techniques, the effect of asymmetric versus symmetric window deformation, number of passes and the interrogation window size. Some of these parameters are found to have a profound effect on the magnitude of the peak-locking error. The effects for specific PIV cameras are also studied experimentally using a precision turntable to generate a known rotating velocity field. Image time series recorded using this experiment show a linear range of pixel and sub-pixel shifts ranging from 0 to  ±4 pixels. Deviations in the constant vorticity field (ω z ) reveal how peak-locking can be affected systematically both by varying parameters of the detection system such as the focal distance and f -number, and also by varying the settings of the PIV analysis. A new a priori technique for reducing the bias errors associated with peak-locking in PIV is introduced using an optical diffuser to avoid undersampled particle images during the recording of the raw images. This technique is evaluated against other a priori approaches using experimental data and is shown to perform favorably. Finally, a new a posteriori anti peak-locking filter (APLF) is developed and investigated, which shows promising results for both synthetic data and real measurements for very small particle image sizes. (paper)

  5. Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Agajanian, Megan; Runa, Farhana; Kelber, Jonathan A., E-mail: jonathan.kelber@csun.edu

    2015-09-25

    /fibronectin-induced ZEB1 expression during EMT. • The PEAK1/CRK/ZEB1 pathway is a novel target for blocking EMT in breast cancer.

  6. Accelerator target

    Science.gov (United States)

    Schlyer, David J.; Ferrieri, Richard A.; Koehler, Conrad

    1999-01-01

    A target includes a body having a depression in a front side for holding a sample for irradiation by a particle beam to produce a radioisotope. Cooling fins are disposed on a backside of the body opposite the depression. A foil is joined to the body front side to cover the depression and sample therein. A perforate grid is joined to the body atop the foil for supporting the foil and for transmitting the particle beam therethrough. A coolant is circulated over the fins to cool the body during the particle beam irradiation of the sample in the depression.

  7. NATIONAL TECHNOLOGICAL INITIATIVE: EVALUATION OF PERSPECTIVES OF RUSSIA'S TECHNOLOGICAL LEADERSHIP

    OpenAIRE

    N. G. Kurakova; A. N. Petrov

    2015-01-01

    There were analysed scientific-technological solutions which are suggested to be included in the National Technological Initiative «New Production technologies» (NSI-NPT). Considering that Russian President set a target to become a technological leader and conquer the noticeable niches of global products and services markets using technologies, the attention has been drawn to the fact that readiness to influence markets of high-technological products is defined by the shares of patents, recei...

  8. Proteomic patterns for classification of ovarian cancer and CTCL serum samples utilizing peak pairs indicative of post-translational modifications.

    Science.gov (United States)

    Liu, Chenwei; Shea, Nancy; Rucker, Sally; Harvey, Linda; Russo, Paul; Saul, Richard; Lopez, Mary F; Mikulskis, Alvydas; Kuzdzal, Scott; Golenko, Eva; Fishman, David; Vonderheid, Eric; Booher, Susan; Cowen, Edward W; Hwang, Sam T; Whiteley, Gordon R

    2007-11-01

    Proteomic patterns as a potential diagnostic technology has been well established for several cancer conditions and other diseases. The use of machine learning techniques such as decision trees, neural networks, genetic algorithms, and other methods has been the basis for pattern determination. Cancer is known to involve signaling pathways that are regulated through PTM of proteins. These modifications are also detectable with high confidence using high-resolution MS. We generated data using a prOTOF mass spectrometer on two sets of patient samples: ovarian cancer and cutaneous t-cell lymphoma (CTCL) with matched normal samples for each disease. Using the knowledge of mass shifts caused by common modifications, we built models using peak pairs and compared this to a conventional technique using individual peaks. The results for each disease showed that a small number of peak pairs gave classification equal to or better than the conventional technique that used multiple individual peaks. This simple peak picking technique could be used to guide identification of important peak pairs involved in the disease process.

  9. Simulations of effusion from ISOL target/ion source systems

    International Nuclear Information System (INIS)

    Mustapha, B.; Nolen, J.A.

    2004-01-01

    Monte Carlo simulations of the low- and high-conductivity Target/Ion Source systems used at Oak Ridge National Laboratory for effusion measurements are performed. Comparisons with the corresponding experimental data for the different geometries are presented and discussed. Independent checks of the simulation using data for simple geometries and using the conductance approach well known in vacuum technology are performed. A simulation-based comparison between the low- and high-conductivity systems is also presented

  10. A cMUT probe for ultrasound-guided focused ultrasound targeted therapy.

    Science.gov (United States)

    Gross, Dominique; Coutier, Caroline; Legros, Mathieu; Bouakaz, Ayache; Certon, Dominique

    2015-06-01

    Ultrasound-mediated targeted therapy represents a promising strategy in the arsenal of modern therapy. Capacitive micromachined ultrasonic transducer (cMUT) technology could overcome some difficulties encountered by traditional piezoelectric transducers. In this study, we report on the design, fabrication, and characterization of an ultrasound-guided focused ultrasound (USgFUS) cMUT probe dedicated to preclinical evaluation of targeted therapy (hyperthermia, thermosensitive liposomes activation, and sonoporation) at low frequency (1 MHz) with simultaneous ultrasonic imaging and guidance (15 to 20 MHz). The probe embeds two types of cMUT arrays to perform the modalities of targeted therapy and imaging respectively. The wafer-bonding process flow employed for the manufacturing of the cMUTs is reported. One of its main features is the possibility of implementing two different gap heights on the same wafer. All the design and characterization steps of the devices are described and discussed, starting from the array design up to the first in vitro measurements: optical (microscopy) and electrical (impedance) measurements, arrays' electroacoustic responses, focused pressure field mapping (maximum peak-to-peak pressure = 2.5 MPa), and the first B-scan image of a wire-target phantom.

  11. 75 FR 38478 - Orders Finding That the Mid-C Financial Peak Daily Contract and Mid-C Financial Off-Peak Daily...

    Science.gov (United States)

    2010-07-02

    ... requested comment on the Mid-C Financial Peak (``MDC'') contract and Mid-C Financial Off-Peak (``OMC... the Mid-C Financial Peak (``MDC'') contract and Mid-C Financial Off-Peak (``OMC'') contract. The MDC and OMC contracts will be addressed in a separate Federal Register release. \\10\\ The Commission's Part...

  12. High peak power sub-nanosecond mode-locked pulse characteristics of Nd:GGG laser

    Science.gov (United States)

    Zhao, Jia; Zhao, Shengzhi; Li, Tao; Li, Yufei; Yang, Kejian; Li, Guiqiu; Li, Dechun; Qiao, Wenchao; Feng, Chuansheng; Wang, Yonggang

    2015-10-01

    Based on the dual-loss modulation, i.e. electro-optic (EO) modulator and GaAs saturable absorber, a sub-nanosecond mode-locked pulsed Nd:GGG laser with kHz repetition rates is presented for the first time. The repetition rate (0.5-10 kHz) of this pulsed laser is controlled by the modulation rate of EO modulator, so high stability can be obtained. The sub-nanosecond pulse width depends on the mode-locked pulse underneath the Q-switched envelope in the Q-switched mode-locked (QML) laser and high peak power can be generated. The condition on the generation of sub-nanosecond pulse and the needed threshold power for different modulation rates of EO are given. The average output power, the pulse width and the peak power versus pump power for different repetition rates are demonstrated. The shortest pulse width is 426 ps and the highest peak power reaches 239.4 kW. The experimental results show that the dual-loss modulation technology with EO and GaAs saturable absorber in QML laser is an efficient method to generate sub-nanosecond mode-locked pulsed laser with kHz repetition rates.

  13. Peak Politics: Resource Scarcity and Libertarian Political Culture in the United States

    Science.gov (United States)

    Schneider-Mayerson, Matthew

    My dissertation uses the "peak oil" movement as a lens to analyze the convergence of apocalyptic environmental thinking and libertarian political culture in the recent United States. The "peak oil" movement was a twenty-first century American social movement of Americans who came to believe that oil depletion and other environmental problems would lead to the imminent collapse of global industrial society. Dedicated adherents developed a rich subculture, primarily online, and prepared themselves for the "post-carbon" future by conserving energy, changing occupations, and even purchasing land. Drawing on surveys of over 1,500 participants, ethnographic research, discourse analysis of peak oil websites and literary analysis of subcultural fiction, my research reveals a group of mostly white, male, liberal Americans struggling with the perceived threat of economic, environmental and geopolitical decline while the country undergoes a broad shift in political culture: the continued rise of libertarian ideals, accelerated by the influence of Internet technology. I view this apocalyptic subculture in the context of petroleum dependence, eco-apocalyptic discourses, the environmental discourse of "limits to growth," white masculinity, climate change, and the influence of conservative individualism on American political culture.

  14. Optimum Peak Current Hysteresis Control for Energy Recovering Converter in CDI Desalination

    Directory of Open Access Journals (Sweden)

    Alberto M. Pernía

    2014-06-01

    Full Text Available Capacitive De-Ionization (CDI is becoming a suitable alternative for desalination. The low cost of the materials required and its reduced energy consumption can be critical factors for developing this technique. CDI technology does not require a high-pressure system and the energy storage capability of CDI cells allows it to be reused in other CDI cells, thus minimizing consumption. The goal of the power stage responsible of the energy recovery is transferring the stored energy from one cell to another with the maximum possible efficiency, thus allowing the desalination process to continue. Assuming hysteresis current control is implemented at the DC/DC (direct current converter, this paper aims to determine the optimum peak current through the inductor in each switching period with a view to maximizing overall efficiency. The geometrical parameters of the desalination cell and the NaCl concentration modify the cell electrical properties. The peak current control of the power stage should be adapted to the cell characteristics so that the efficiency behavior of the whole CDI system can be improved. The mathematical model defined in this paper allows the CDI plant automation using the peak inductor current as control variable, adapting its value to the salt concentration during the desalination process.

  15. Revisiting the Correlations of Peak Luminosity with Spectral Lag and Peak Energy of the Observed Gamma-ray Bursts

    Directory of Open Access Journals (Sweden)

    Yun-A Jo

    2016-12-01

    Full Text Available An analysis of light curves and spectra of observed gamma-ray bursts in gamma-ray ranges is frequently demanded because the prompt emission contains immediate details regarding the central engine of gamma-ray bursts (GRBs. We have revisited the relationship between the collimation-corrected peak luminosity and the spectral lag, investigating the lag-luminosity relationships in great detail by focusing on spectral lags resulting from all possible combinations of channels. Firstly, we compiled the opening angle data and demonstrated that the distribution of opening angles of 205 long GRBs is represented by a double Gaussian function having maxima at ~ 0.1 and ~ 0.3 radians. We confirmed that the peak luminosity and the spectral lag are anti-correlated, both in the observer frame and in the source frame. We found that, in agreement with our previous conclusion, the correlation coefficient improves significantly in the source frame. It should be noted that spectral lags involving channel 2 (25-50 keV yield high correlation coefficients, where Swift/Burst Alert Telescope (BAT has four energy channels (channel 1: 15-25 keV, channel 2: 25-50 keV, channel 3: 50-100 keV, channel 4: 100-200 keV. We also found that peak luminosity is positively correlated with peak energy.

  16. Ionoacoustic characterization of the proton Bragg peak with submillimeter accuracy

    Energy Technology Data Exchange (ETDEWEB)

    Assmann, W., E-mail: walter.assmann@lmu.de; Reinhardt, S.; Lehrack, S.; Edlich, A.; Thirolf, P. G.; Parodi, K. [Department for Medical Physics, Ludwig-Maximilians-Universität München, Am Coulombwall 1, Garching 85748 (Germany); Kellnberger, S.; Omar, M.; Ntziachristos, V. [Institute for Biological and Medical Imaging, Technische Universität München and Helmholtz Zentrum München, Ingolstädter Landstrasse 1, Neuherberg 85764 (Germany); Moser, M.; Dollinger, G. [Institute for Applied Physics and Measurement Technology, Universität der Bundeswehr, Werner-Heisenberg-Weg 39, Neubiberg 85577 (Germany)

    2015-02-15

    Purpose: Range verification in ion beam therapy relies to date on nuclear imaging techniques which require complex and costly detector systems. A different approach is the detection of thermoacoustic signals that are generated due to localized energy loss of ion beams in tissue (ionoacoustics). Aim of this work was to study experimentally the achievable position resolution of ionoacoustics under idealized conditions using high frequency ultrasonic transducers and a specifically selected probing beam. Methods: A water phantom was irradiated by a pulsed 20 MeV proton beam with varying pulse intensity and length. The acoustic signal of single proton pulses was measured by different PZT-based ultrasound detectors (3.5 and 10 MHz central frequencies). The proton dose distribution in water was calculated by Geant4 and used as input for simulation of the generated acoustic wave by the matlab toolbox k-WAVE. Results: In measurements from this study, a clear signal of the Bragg peak was observed for an energy deposition as low as 10{sup 12} eV. The signal amplitude showed a linear increase with particle number per pulse and thus, dose. Bragg peak position measurements were reproducible within ±30 μm and agreed with Geant4 simulations to better than 100 μm. The ionoacoustic signal pattern allowed for a detailed analysis of the Bragg peak and could be well reproduced by k-WAVE simulations. Conclusions: The authors have studied the ionoacoustic signal of the Bragg peak in experiments using a 20 MeV proton beam with its correspondingly localized energy deposition, demonstrating submillimeter position resolution and providing a deep insight in the correlation between the acoustic signal and Bragg peak shape. These results, together with earlier experiments and new simulations (including the results in this study) at higher energies, suggest ionoacoustics as a technique for range verification in particle therapy at locations, where the tumor can be localized by ultrasound

  17. Asthma-like peak flow variability in various lung diseases

    Directory of Open Access Journals (Sweden)

    Virendra Singh

    2012-01-01

    Full Text Available Background and Objectives: Bronchodilator reversibility and diurnal peak flow variability are considered characteristic of asthma patients. Patients with chronic obstructive pulmonary disease (COPD show poor reversibility. But reversibility and variability in other pulmonary diseases manifesting with airflow obstruction in not known. Therefore, we assessed reversibility and peak flow variability in patients with various lung diseases to recognize the pattern. Materials and Methods : Seventy consecutive patients with a diagnosis of lung diseases manifesting with airflow obstruction were recruited in the study. These included 23 patients with asthma, 11 patients with bronchiectasis, 16 patients with post-tubercular lung disease (PTLD, and 20 patients with COPD. Ten healthy matched control subjects were also selected to pair with asthmatic patients. Bronchodilator reversibility test was done initially and peak expiratory flow rate (PEFR was measured for a duration of 1 week by patients themselves on a chart that was given to them. The mean amplitude percentage of these records were analyzed. Results : The mean values of peak flow variability were 14.73% ± 6.1% in asthmatic patients, 11.98% ± 7.5% in patients with bronchiectasis, and 10.54% ± 5.3% in PTLD. The difference in the mean values of peak flow variability between asthma and bronchiectasis, that is, 14.73 (6.1 vs 11.98 (7.5 was not statistically significant (P > 0.05. Forced expiratory volume one second (FEV 1 reversibility values were 14.77% ± 26.93%, 11.24% ± 20.43%, 10.85% ± 13.02%, 16.83% ± 22.84%, and 5.47% ± 4.99% in asthma, COPD, PTLD, bronchiectasis, and healthy subjects, respectively. Conclusion: Both reversibility and diurnal peak flow variability were higher in patients with various lung diseases compared with normal healthy subjects. Although these are characteristic of asthma, some cases of bronchiectasis and PTLD patients may also manifest asthma-like PEFR variability

  18. Hurricane Mitch: Peak Discharge for Selected River Reachesin Honduras

    Science.gov (United States)

    Smith, Mark E.; Phillips, Jeffrey V.; Spahr, Norman E.

    2002-01-01

    Hurricane Mitch began as a tropical depression in the Caribbean Sea on 22 October 1998. By 26 October, Mitch had strengthened to a Category 5 storm as defined by the Saffir-Simpson Hurricane Scale (National Climate Data Center, 1999a), and on 27 October was threatening the northern coast of Honduras (fig. 1). After making landfall 2 days later (29 October), the storm drifted south and west across Honduras, wreaking destruction throughout the country before reaching the Guatemalan border on 31 October. According to the National Climate Data Center of the National Oceanic and Atmospheric Administration (National Climate Data Center, 1999b), Hurricane Mitch ranks among the five strongest storms on record in the Atlantic Basin in terms of its sustained winds, barometric pressure, and duration. Hurricane Mitch also was one of the worst Atlantic storms in terms of loss of life and property. The regionwide death toll was estimated to be more than 9,000; thousands of people were reported missing. Economic losses in the region were more than $7.5 billion (U.S. Agency for International Development, 1999). Honduras suffered the most widespread devastation during the storm. More than 5,000 deaths, and economic losses of more than $4 billion, were reported by the Government of Honduras. Honduran officials estimated that Hurricane Mitch destroyed 50 years of economic development. In addition to the human and economic losses, intense flooding and landslides scarred the Honduran landscape - hydrologic and geomorphologic processes throughout the country likely will be affected for many years. As part of the U.S. Government's response to the disaster, the U.S. Geological Survey (USGS) conducted post-flood measurements of peak discharge at 16 river sites throughout Honduras (fig. 2). Such measurements, termed 'indirect' measurements, are used to determine peak flows when direct measurements (using current meters or dye studies, for example) cannot be made. Indirect measurements of

  19. Ketamine increases the frequency of electroencephalographic bicoherence peak on the alpha spindle area induced with propofol.

    Science.gov (United States)

    Hayashi, K; Tsuda, N; Sawa, T; Hagihira, S

    2007-09-01

    The reticular and thalamocortical system is known to play a prominent role in spindle wave activity, and the spindle wave is related to the sedative effects of anaesthetics. Recently, bispectral analysis of the EEG has been developed as a better method to indicate nonlinear regulation including the thalamocortical system linking to the cortical area. In the present study, in order to explore the interference of ketamine with the nonlinear regulation of the sub-cortical system, we examined the effect of ketamine on spindle alpha waves through the bispectral analysis. The study included 21 patients. Anaesthesia was induced and maintained using a propofol-TCI system (target-controlled infusion, with target concentration 3.5 microg ml(-1)). An A-2000 BIS monitor was used and the raw EEG signals were collected via an RS232 interface on a personal computer. Bicoherence, the normalized bispectrum, and power spectrum were analysed before and after i.v. administration of 1 mg kg(-1) racemic ketamine. Propofol caused alpha peaks in both power and bicoherence spectra, with average frequencies of 10.6 (SD 0.9) Hz and 10.7 (1.0) Hz, respectively. The addition of ketamine significantly shifted each peak to frequencies of 14.4 (1.4) Hz and 13.6 (1.5) Hz, respectively [P < 0.05, mean (SD)]. Ketamine shifted the alpha peaks of bicoherence induced by propofol to higher frequencies. This suggests that ketamine changes the alpha spindle rhythms through the modulation of the nonlinear sub-cortical reverberating network.

  20. Peak power, ground reaction forces, and velocity during the squat exercise performed at different loads.

    Science.gov (United States)

    Zink, Attila J; Perry, Arlette C; Robertson, Bobby L; Roach, Kathryn E; Signorile, Joseph F

    2006-08-01

    This study examined the changes in peak power, ground reaction force and velocity with different loads during the performance of the parallel squat movement. Twelve experienced male lifters (26.83 +/- 4.67 years of age) performed the standard parallel squat, using loads equal to 20, 30, 40, 50, 60, 70, 80, and 90% of 1 repetition maximum (1RM). Each subject performed all parallel squats with as much explosiveness as possible using his own technique. Peak power (PP), peak ground reaction force (PGRF), peak barbell velocity (PV), force at the time of PP (FPP), and velocity at the time of PP (VPP) were determined from force, velocity, and power curves calculated using barbell velocity and ground reaction force data. No significant differences were detected among loads for PP; however, the greatest PP values were associated with loads of 40 and 50% of 1RM. Higher loads produced greater PGRF and FPP values than lower loads (p < 0.05) in all cases except between loads equal to 60-50, 50-40, and 40-30% of 1RM for PGRF, and between loads equal to 70-60 and 60-50% of 1RM for FPP. Higher loads produced lower PV and VPP values than lower loads (p < 0.05) in all cases except between the 20-30, 70-80, and 80-90% of 1RM conditions. These results may be helpful in determining loads when prescribing need-specific training protocols targeting different areas of the load-velocity continuum.

  1. Determination of the diagnostic x-ray tube practical peak voltage (PPV) from average or average peak voltage measurements.

    Science.gov (United States)

    Hourdakis, C J

    2011-04-07

    The practical peak voltage (PPV) has been adopted as the reference measuring quantity for the x-ray tube voltage. However, the majority of commercial kV-meter models measure the average peak, Ū(P), the average, Ū, the effective, U(eff) or the maximum peak, U(P) tube voltage. This work proposed a method for determination of the PPV from measurements with a kV-meter that measures the average Ū or the average peak, Ū(p) voltage. The kV-meter reading can be converted to the PPV by applying appropriate calibration coefficients and conversion factors. The average peak k(PPV,kVp) and the average k(PPV,Uav) conversion factors were calculated from virtual voltage waveforms for conventional diagnostic radiology (50-150 kV) and mammography (22-35 kV) tube voltages and for voltage ripples from 0% to 100%. Regression equation and coefficients provide the appropriate conversion factors at any given tube voltage and ripple. The influence of voltage waveform irregularities, like 'spikes' and pulse amplitude variations, on the conversion factors was investigated and discussed. The proposed method and the conversion factors were tested using six commercial kV-meters at several x-ray units. The deviations between the reference and the calculated-according to the proposed method-PPV values were less than 2%. Practical aspects on the voltage ripple measurement were addressed and discussed. The proposed method provides a rigorous base to determine the PPV with kV-meters from Ū(p) and Ū measurement. Users can benefit, since all kV-meters, irrespective of their measuring quantity, can be used to determine the PPV, complying with the IEC standard requirements.

  2. Can double-peaked lines indicate merging effects in AGNs?

    Directory of Open Access Journals (Sweden)

    Popović L.Č.

    2000-01-01

    Full Text Available The influence of merging effects in the central part of an Active Galactic Nucleus (AGN on the emission spectral line shapes are discussed. We present a model of close binary Broad Line Region. The numerical experiments show that the merging effects can explain double peaked lines. The merging effects may also be present in the center of AGNs, although they emit slightly asymmetric as well as symmetric and relatively stable (in profile shape spectral lines. Depending on the black hole masses and their orbit elements such model may explain some of the line profile shapes observed in AGNs. This work shows that if one is looking for the merging effects in the central region as well as in the wide field structure of AGNs, he should first pay attention to objects which have double peaked lines.

  3. Kinematic evidence for downdip movement on the Mormon Peak detachment

    Science.gov (United States)

    Walker, Christopher D.; Anders, Mark H.; Christie-Blick, Nicholas

    2007-03-01

    The Mormon Peak detachment is considered to be one of the best examples of a rooted upper crustal detachment fault that propagated through the brittle crust at a low angle. The hanging wall of the detachment today consists of a number of isolated blocks that have been interpreted as remnants of a once-contiguous extensional allochthon. Here we present the results of a new study of directional indicators from the basal surfaces beneath these blocks. These measurements do not agree with the long-standing interpretation of a S75°W movement direction for the detachment hanging wall. Instead, the most recent movement on each section of the detachment took place approximately parallel to the present downdip direction. We conclude that the Mormon Peak detachment is best explained as the basal surfaces to a series of rootless gravity slides.

  4. How does economic theory explain the Hubbert peak oil model?

    International Nuclear Information System (INIS)

    Reynes, F.; Okullo, S.; Hofkes, M.

    2010-01-01

    The aim of this paper is to provide an economic foundation for bell shaped oil extraction trajectories, consistent with Hubbert's peak oil model. There are several reasons why it is important to get insight into the economic foundations of peak oil. As production decisions are expected to depend on economic factors, a better comprehension of the economic foundations of oil extraction behaviour is fundamental to predict production and price over the coming years. The investigation made in this paper helps us to get a better understanding of the different mechanisms that may be at work in the case of OPEC and non-OPEC producers. We show that profitability is the main driver behind production plans. Changes in profitability due to divergent trajectories between costs and oil price may give rise to a Hubbert production curve. For this result we do not need to introduce a demand or an exploration effect as is generally assumed in the literature.

  5. Estimating peak flow characteristics at ungaged sites by ridge regression

    Science.gov (United States)

    Tasker, Gary D.

    1982-01-01

    A regression simulation model, is combined with a multisite streamflow generator to simulate a regional regression of 50-year peak discharge against a set of basin characteristics. Monte Carlo experiments are used to compare the unbiased ordinary lease squares parameter estimator with Hoerl and Kennard's (1970a) ridge estimator in which the biasing parameter is that proposed by Hoerl, Kennard, and Baldwin (1975). The simulation results indicate a substantial improvement in parameter estimation using ridge regression when the correlation between basin characteristics is more than about 0.90. In addition, results indicate a strong potential for improving the mean square error of prediction of a peak-flow characteristic versus basin characteristics regression model when the basin characteristics are approximately colinear. The simulation covers a range of regression parameters, streamflow statistics, and basin characteristics commonly found in regional regression studies.

  6. Double peak effect in microdosimetric proportional counters and its interpretation

    International Nuclear Information System (INIS)

    Bednarek, B.; Olko, P.; Booz, J.

    1989-01-01

    In calibration measurements with low energy X-rays, a double peak effect appears in low pressure proportional counters with a helix, when used for simulation of tissue equivalent diameters considerably larger than 2 μm. An interpretation of this phenomenon is discussed, based upon electron capture and electric field perturbation at the counter helix. A description of the physical processes is presented showing that the double peak effect is a problem in the case of helix counters (called also Rossi counters) for all simulated diameters. Conclusions are drawn on systematic errors introduced by the counter helix into microdosimetric spectra and anti y D of photons and neutrons. The authors recommend to use cylindrical counters with optimized geometrical and electronic parameters rather than the spherical counters with a helix discussed. (orig.)

  7. In vivo dissolution measurement with indium-111 summation peak ratios

    International Nuclear Information System (INIS)

    Jay, M.; Woodward, M.A.; Brouwer, K.R.

    1985-01-01

    Dissolution of [ 111 In]labeled tablets was measured in vivo in a totally noninvasive manner by using a modification of the perturbed angular correlation technique known as the summation peak ratio method. This method, which requires the incorporation of only 10-12 microCi into the dosage form, provided reliable dissolution data after oral administration of [ 111 In]lactose tablets. These results were supported by in vitro experiments which demonstrated that the dissolution rate as measured by the summation peak ratio method was in close agreement with the dissolution rate of salicylic acid in a [ 111 In]salicylic acid tablet. The method has the advantages of using only one detector, thereby avoiding the need for complex coincidence counting systems, requiring less radioactivity, and being potentially applicable to a gamma camera imaging system

  8. The Twin Peaks in 3-D, as Viewed by the Mars Pathfinder IMP Camera

    Science.gov (United States)

    1997-01-01

    The Twin Peaks are modest-size hills to the southwest of the Mars Pathfinder landing site. They were discovered on the first panoramas taken by the IMP camera on the 4th of July, 1997, and subsequently identified in Viking Orbiter images taken over 20 years ago. The peaks are approximately 30-35 meters (-100 feet) tall. North Twin is approximately 860 meters (2800 feet) from the lander, and South Twin is about a kilometer away (3300 feet). The scene includes bouldery ridges and swales or 'hummocks' of flood debris that range from a few tens of meters away from the lander to the distance of the South Twin Peak. The large rock at the right edge of the scene is nicknamed 'Hippo'. This rock is about a meter (3 feet) across and 25 meters (80 feet) distant.This view of the Twin Peaks was produced by combining 4 individual 'Superpan' scenes from the left and right eyes of the IMP camera to cover both peaks. Each frame consists of 8 individual frames (left eye) and 7 frames (right eye) taken with different color filters that were enlarged by 500% and then co-added using Adobe Photoshop to produce, in effect, a super-resolution pancromatic frame that is sharper than an individual frame would be.The anaglyph view of the Twin Peaks was produced by combining the left and right eye mosaics (above) by assigning the left eye view to the red color plane and the right eye view to the green and blue color planes (cyan), to produce a stereo anaglyph mosaic. This mosaic can be viewed in 3-D on your computer monitor or in color print form by wearing red-blue 3-D glasses.Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is a division of the California Institute of Technology (Caltech). The IMP was developed by the University of Arizona Lunar and Planetary Laboratory under

  9. Physics of polarized targets

    CERN Document Server

    Niinikoski, Tapio

    2014-01-01

    For developing, building and operating solid polarized targets we need to understand several fields of physics that have seen sub stantial advances during the last 50 years. W e shall briefly review a selection of those that are important today. These are: 1) quantum statistical methods to describe saturation and relaxation in magnetic resonance; 2) equal spin temperature model for dy namic nuclear polarization; 3 ) weak saturation during NMR polarization measurement; 4 ) refrigeration using the quantum fluid properties of helium isotopes. These, combined with superconducting magnet technologies, permit today to reach nearly complete pola rization of almost any nuclear spins. Targets can be operated in frozen spin mode in rather low and inhomogeneous field of any orientation, and in DNP mode in beams of high intensity. Beyond such experiments of nuclear and particle physics, applications a re also emerging in macromolecular chemistry and in magnetic resonance imaging. This talk is a tribute to Michel Borghini...

  10. The need for standardisation of peak flow charts

    OpenAIRE

    Reddel, H; Vincent, S; Civitico, J

    2005-01-01

    Peak expiratory flow (PEF) monitoring is recommended in asthma guidelines as a tool for assessing severity, monitoring response to treatment, detecting exacerbations, identifying triggers, and providing objective justification for treatment to the patient, but some clinicians have expressed concerns about its relevance in the management of asthma. We have identified a sevenfold variation in the scale of existing PEF charts, with resulting wide variation in the appearance of the same PEF date ...

  11. Twin-Peak QPOs from Oscillating Torus with Cusp

    Science.gov (United States)

    Sramkova, Eva

    2017-08-01

    We propose a model of HF twin-peak quasi-periodic oscillations assuming an oscillating torus with cusp that changes location of its centre around radii very close to innermost stable circular orbit. The observed variability is assigned to global modes of accreted fluid motion that may give rise to strong modulation of both the accretion disc radiation and the accretion rate. We illustrate that predictions of the model well match observational data for a dozen of sources.

  12. Peak-counts blood flow model-errors and limitations

    International Nuclear Information System (INIS)

    Mullani, N.A.; Marani, S.K.; Ekas, R.D.; Gould, K.L.

    1984-01-01

    The peak-counts model has several advantages, but its use may be limited due to the condition that the venous egress may not be negligible at the time of peak-counts. Consequently, blood flow measurements by the peak-counts model will depend on the bolus size, bolus duration, and the minimum transit time of the bolus through the region of interest. The effect of bolus size on the measurement of extraction fraction and blood flow was evaluated by injecting 1 to 30ml of rubidium chloride in the femoral vein of a dog and measuring the myocardial activity with a beta probe over the heart. Regional blood flow measurements were not found to vary with bolus sizes up to 30ml. The effect of bolus duration was studied by injecting a 10cc bolus of tracer at different speeds in the femoral vein of a dog. All intravenous injections undergo a broadening of the bolus duration due to the transit time of the tracer through the lungs and the heart. This transit time was found to range from 4-6 second FWHM and dominates the duration of the bolus to the myocardium for up to 3 second injections. A computer simulation has been carried out in which the different parameters of delay time, extraction fraction, and bolus duration can be changed to assess the errors in the peak-counts model. The results of the simulations show that the error will be greatest for short transit time delays and for low extraction fractions

  13. Peak earthquake response of structures under multi-component excitations

    Science.gov (United States)

    Song, Jianwei; Liang, Zach; Chu, Yi-Lun; Lee, George C.

    2007-12-01

    Accurate estimation of the peak seismic responses of structures is important in earthquake resistant design. The internal force distributions and the seismic responses of structures are quite complex, since ground motions are multi-directional. One key issue is the uncertainty of the incident angle between the directions of ground motion and the reference axes of the structure. Different assumed seismic incidences can result in different peak values within the scope of design spectrum analysis for a given structure and earthquake ground motion record combination. Using time history analysis to determine the maximum structural responses excited by a given earthquake record requires repetitive calculations to determine the critical incident angle. This paper presents a transformation approach for relatively accurate and rapid determination of the maximum peak responses of a linear structure subjected to three-dimensional excitations within all possible seismic incident angles. The responses can be deformations, internal forces, strains and so on. An irregular building structure model is established using SAP2000 program. Several typical earthquake records and an artificial white noise are applied to the structure model to illustrate the variation of the maximum structural responses for different incident angles. Numerical results show that for many structural parameters, the variation can be greater than 100%. This method can be directly applied to time history analysis of structures using existing computer software to determine the peak responses without carrying out the analyses for all possible incident angles. It can also be used to verify and/or modify aseismic designs by using response spectrum analysis.

  14. Peak effect at microwave frequencies in swift heavy ion irradiated ...

    Indian Academy of Sciences (India)

    few tens of Hz to a few MHz, probing the dynamics of the FLL revealed no frequency dependence of the peak position of the PE .... 19, 217 (1969). [5] A I Larkin and Y N Ovchinnikov, J. Low Temp. Phys. 34, 409 (1979). [6] J I Gittleman and B Rosenblum, Phys. Rev. Lett. 16, 734 (1966). [7] A R Bhangale et al, Phys. Rev. B63 ...

  15. Implications of "peak oil" for atmospheric CO2 and climate

    OpenAIRE

    Kharecha, Pushker A.; Hansen, James E.

    2007-01-01

    Unconstrained CO2 emission from fossil fuel burning has been the dominant cause of observed anthropogenic global warming. The amounts of "proven" and potential fossil fuel reserves are uncertain and debated. Regardless of the true values, society has flexibility in the degree to which it chooses to exploit these reserves, especially unconventional fossil fuels and those located in extreme or pristine environments. If conventional oil production peaks within the next few decades, it may have a...

  16. General Merrill A. McPeak Leadership and Organizational Change

    Science.gov (United States)

    2001-06-01

    GENERAL MERRILL A. MCPEAK LEADERSHIP AND ORGANIZATIONAL CHANGE BY MAJOR THOMAS A. BUSSIERE A THESIS PRESENTED TO THE...Covered (from... to) - Title and Subtitle General Merrill A. McPeak Leadership and Organizational Change Contract Number Grant Number Program Element...General McPeak�s leadership. The sections of each case focus on the particular issues associated with organizational change and leadership. The

  17. Single-peak solitary wave solutions for the variant Boussinesq ...

    Indian Academy of Sciences (India)

    Zhang and Chen [6] obtained new types of cusped solitons of a partial differential equation by setting the partial differential equation under inhomogeneous .... (ii) For g = 0. If ψ(0) = 0, by eq. (2.8) we know ψ (0) exists. According to the definition of peak point, we have ψ (0) = 0. However, by eq. (2.8) we must have ψ(0) = A, ...

  18. Automatic acquisition and shape analysis of metastable peaks

    International Nuclear Information System (INIS)

    Maendli, H.; Robbiani, R.; Kuster, Th.; Seibl, J.

    1979-01-01

    A method for automatic acquisition and evaluation of metastable peaks due to transitions in the first field-free region of a double focussing mass spectrometer is presented. The data are acquired by computer-controlled repetitive scanning of the accelerating voltage and concomitant accumulation, the evaluation made by a mathematical derivatization of the resulting curve. Examples for application of the method are given. (Auth.)

  19. Peak signal-to-noise ratio revisited: Is simple beautiful?

    DEFF Research Database (Denmark)

    Korhonen, Jari; You, Junyong

    2012-01-01

    Heavy criticism has been directed against using peak signal-to-noise ratio (PSNR) as a full reference quality metric for digitally processed images and video, since many studies have shown a weak correlation between subjective quality scores and the respective PSNR values. In this paper, we show...... quality models known from the literature. Therefore, the use of PSNR may be justified for comparative quality assessment with fixed content....

  20. Cranial Indicators Identified for Peak Incidence of Otitis Media.

    Science.gov (United States)

    Pagano, Anthony S; Wang, Eugene; Yuan, Derek; Fischer, Daniel; Bluestone, Charles; Marquez, Samuel; Laitman, Jeffrey

    2017-10-01

    Acute otitis media (AOM) is one of the most common pediatric conditions worldwide. Peak age of occurrence for AOM has been identified within the first postnatal year and it remains frequent until approximately six postnatal years. Morphological differences between adults and infants in the cartilaginous Eustachian tube (CET) and associated structures may be responsible for development of this disease yet few have investigated normal growth trajectories. We tested hypotheses on coincidence of skeletal growth changes and known ages of peak AOM occurrence. Growth was divided into five dental eruption stages ranging from edentulous neonates (Stage 1) to adults with erupted third maxillary molars (Stage 5). A total of 32 three-dimensional landmarks were used and Generalized Procrustes Analysis was performed. Next, we performed principal components analysis and calculated univariate measures. It was found that growth change in Stage 1 was the most rapid and comprised the largest amount of overall growth in upper respiratory tract proportions (where time is represented by the natural logarithmic transformation of centroid size). The analysis of univariate measures showed that Stage 1 humans did indeed possess the relatively shortest and most horizontally oriented CET's with the greatest amount of growth change occurring at the transition to Stage 2 (eruption of deciduous dentition at five postnatal months, commencing peak AOM incidence) and ceasing by Stage 3 (approximately six postnatal years). Skeletal indicators appear related to peak ages of AOM incidence and may contribute to understanding of a nearly ubiquitous human disease. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 300:1721-1740, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.