WorldWideScience

Sample records for technology program developmental

  1. How and Why Higher Education Institutions Use Technology in Developmental Education Programming. A CAPR Working Paper

    Science.gov (United States)

    Natow, Rebecca S.; Reddy, Vikash; Grant, Markeisha

    2017-01-01

    As postsecondary institutions increasingly integrate technology into developmental education, it becomes important to understand how technology is used in these programs, what challenges institutions have encountered relating to the technology, and what considerations institutional leaders take into account when deciding whether and how to…

  2. Transgenerational developmental programming.

    Science.gov (United States)

    Aiken, Catherine E; Ozanne, Susan E

    2014-01-01

    The concept of developmental programming suggests that the early life environment influences offspring characteristics in later life, including the propensity to develop diseases such as the metabolic syndrome. There is now growing evidence that the effects of developmental programming may also manifest in further generations without further suboptimal exposure. This review considers the evidence, primarily from rodent models, for effects persisting to subsequent generations, and evaluates the mechanisms by which developmental programming may be transmitted to further generations. In particular, we focus on the potential role of the intrauterine environment in contributing to a developmentally programmed phenotype in subsequent generations. The literature was systematically searched at http://pubmed.org and http://scholar.google.com to identify published findings regarding transgenerational (F2 and beyond) developmental programming effects in human populations and animal models. Transmission of programming effects is often viewed as a form of epigenetic inheritance, either via the maternal or paternal line. Evidence exists for both germline and somatic inheritance of epigenetic modifications which may be responsible for phenotypic changes in further generations. However, there is increasing evidence for the role of both extra-genomic components of the zygote and the interaction of the developing conceptus with the intrauterine environment in propagating programming effects. The contribution of a suboptimal reproductive tract environment or maternal adaptations to pregnancy may be critical to inheritance of programming effects via the maternal line. As the effects of age exacerbate the programmed metabolic phenotype, advancing maternal age may increase the likelihood of developmental programming effects being transmitted to further generations. We suggest that developmental programming effects could be propagated through the maternal line de novo in generations

  3. Developmental programming of happiness.

    Science.gov (United States)

    Schmidt, Louis A; Fortier, Paz; Lahat, Ayelet; Tang, Alva; Mathewson, Karen J; Saigal, Saroj; Boyle, Michael H; Van Lieshout, Ryan J

    2017-09-01

    Being born at an extremely low birth weight (ELBW; programming hypotheses. Interfacing prenatal programming and differential susceptibility hypotheses, we tested whether individuals with ELBW in different childhood rearing environments showed different attention biases to positive and negative facial emotions in adulthood. Using the oldest known, prospectively followed cohort of ELBW survivors, we found that relative to normal birth weight controls (NBW; >2,500 grams), ELBW survivors displayed the highest and lowest attention bias to happy faces at age 30-35, depending on whether their total family income at age 8 was relatively low (environmental match) or high (environmental mismatch), respectively. This bias to happy faces was associated with a reduced likelihood of emotional problems. Findings suggest that differential susceptibility to positive emotions may be prenatally programmed, with effects lasting into adulthood. We discuss implications for integrating prenatal programming and differential susceptibility hypotheses, and the developmental origins of postnatal plasticity and resilience. © 2017 Wiley Periodicals, Inc.

  4. Developmental Kindergarten Program Evaluation Report.

    Science.gov (United States)

    Blois, George T.; Cushing, Katherine S.

    The evaluation of the Developmental Kindergarten (DK) Program at the Harrison School District #2, Colorado Springs, Colorado, involved pre- and post-testing of student academic gains and interviewing of principals and teachers. The program aimed to provide developmentally appropriate activities for students believed to be "at risk" of…

  5. Developmental programming of auditory learning

    Directory of Open Access Journals (Sweden)

    Melania Puddu

    2012-10-01

    Full Text Available The basic structures involved in the development of auditory function and consequently in language acquisition are directed by genetic code, but the expression of individual genes may be altered by exposure to environmental factors, which if favorable, orient it in the proper direction, leading its development towards normality, if unfavorable, they deviate it from its physiological course. Early sensorial experience during the foetal period (i.e. intrauterine noise floor, sounds coming from the outside and attenuated by the uterine filter, particularly mother’s voice and modifications induced by it at the cochlear level represent the first example of programming in one of the earliest critical periods in development of the auditory system. This review will examine the factors that influence the developmental programming of auditory learning from the womb to the infancy. In particular it focuses on the following points: the prenatal auditory experience and the plastic phenomena presumably induced by it in the auditory system from the basilar membrane to the cortex;the involvement of these phenomena on language acquisition and on the perception of language communicative intention after birth;the consequences of auditory deprivation in critical periods of auditory development (i.e. premature interruption of foetal life.

  6. Wanted: A Developmentally Oriented Alcohol Prevention Program.

    Science.gov (United States)

    Spoth, Richard; Rosenthal, David

    1980-01-01

    Describes an alcohol prevention program with a comprehensive developmental skills orientation. The program includes values clarification, decision making, career planning and communication skills, assertiveness and relaxation training, and relationship with parents and peers. (Author/JAC)

  7. Korea's developmental program for superconductivity

    Science.gov (United States)

    Hong, Gye-Won; Won, Dong-Yeon; Kuk, Il-Hyun; Park, Jong-Chul

    1995-04-01

    Superconductivity research in Korea was firstly carried out in the late 70's by a research group in Seoul National University (SNU), who fabricated a small scale superconducting magnetic energy storage system under the financial support from Korea Electric Power Company (KEPCO). But a few researchers were involved in superconductivity research until the oxide high Tc superconductor was discovered by Bednorz and Mueller. After the discovery of YBaCuO superconductor operating above the boiling point of liquid nitrogen (77 K)(exp 2), Korean Ministry of Science and Technology (MOST) sponsored a special fund for the high Tc superconductivity research to universities and national research institutes by recognizing its importance. Scientists engaged in this project organized 'High Temperature Superconductivity Research Association (HITSRA)' for effective conducting of research. Its major functions are to coordinate research activities on high Tc superconductivity and organize the workshop for active exchange of information. During last seven years the major superconductivity research has been carried out through the coordination of HITSRA. The major parts of the Korea's superconductivity research program were related to high temperature superconductor and only a few groups were carrying out research on conventional superconductor technology, and Korea Atomic Energy Research Institute (KAERI) and Korea Electrotechnology Research Institute (KERI) have led this research. In this talk, the current status and future plans of superconductivity research in Korea will be reviewed based on the results presented in interim meeting of HITSRA, April 1-2, 1994. Taejeon, as well as the research activity of KAERI.

  8. Gestational Hyperandrogenism in Developmental Programming

    Science.gov (United States)

    Hakim, Christopher; Padmanabhan, Vasantha

    2017-01-01

    Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. The potential causes of androgen excess in women include polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity among many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. The present report reviews the various phenotypes of hyperandrogenism during pregnancy and its origin, pathophysiology, and the effect of hyperandrogenism on the fetal developmental trajectory and offspring consequences. PMID:27967205

  9. The use of technology for delivering a weight loss program for adolescents with intellectual and developmental disabilities.

    Science.gov (United States)

    Ptomey, Lauren T; Sullivan, Debra K; Lee, Jaehoon; Goetz, Jeannine R; Gibson, Cheryl; Donnelly, Joseph E

    2015-01-01

    Adolescents with intellectual and developmental disabilities (IDD) are at an increased risk of obesity, with up to 55% considered overweight and 31% obese. However, there has been minimal research on weight management strategies for adolescents with IDD. The purpose of this study was to compare the effectiveness of two weight loss diets, an enhanced Stop Light Diet (eSLD) and a conventional diet (CD), and to determine the feasibility of using tablet computers as a weight loss tool in overweight and obese adolescents with IDD. A 2-month pilot intervention was conducted. All participants were randomized to the eSLD or CD and were given a tablet computer that they used to track daily dietary intake and physical activity. Participants and parents met weekly with a registered dietitian nutritionist via video chat on the tablet computer to receive diet and physical activity feedback and education. Twenty participants (45% female, aged 14.9±2.2 years) were randomized and completed the intervention. Participants in both diets were able to lose weight, and there were no significant differences between the eSLD and CD (-3.89±2.66 kg vs -2.22±1.37 kg). Participants were able to use the tablet computer to track their dietary intake 83.4%±21.3% of possible days and to attend 80.0% of the video chat meetings. Both dietary interventions appear to promote weight loss in adolescents with IDD, and the use of tablet computers appears to be a feasible tool to deliver a weight loss intervention in adolescents with IDD. Copyright © 2015 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  10. Developmental Light-Water Reactor Program

    International Nuclear Information System (INIS)

    Forsberg, C.W.

    1989-12-01

    This report summarizes the progress of the Developmental Light-Water Reactor (DLWR) Program at Oak Ridge National Laboratory in FY 1989. It also includes (1) a brief description of the program, (2) definition of goals, (3) earlier achievements, and (4) proposed future activities

  11. Developmental Challenges of SMES Technology for Applications

    Science.gov (United States)

    Rong, Charles C.; Barnes, Paul N.

    2017-12-01

    This paper reviews the current status of high temperature superconductor (HTS) based superconducting magnetic energy storage (SMES) technology as a developmental effort. Discussion centres on the major challenges in magnet optimization, loss reduction, cooling improvement, and new development of quench detection. The cryogenic operation for superconductivity in this technological application requires continued research and development, especially with a greater engineering effort that involves the end user. For the SMES-based technology to more fully mature, some suggestions are given for consideration and discussion.

  12. Developmental programming and transgenerational transmission of obesity.

    Science.gov (United States)

    Vickers, M H

    2014-01-01

    The global obesity pandemic is often causally linked to marked changes in diet and lifestyle, namely marked increases in dietary intakes of high-energy diets and concomitant reductions in physical activity levels. However, far less attention has been paid to the role of developmental plasticity and alterations in phenotypic outcomes resulting from environmental perturbations during the early-life period. Human and animal studies have highlighted the link between alterations in the early-life environment and increased susceptibility to obesity and related metabolic disorders in later life. In particular, altered maternal nutrition, including both undernutrition and maternal obesity, has been shown to lead to transgenerational transmission of metabolic disorders. This association has been conceptualised as the developmental programming hypothesis whereby the impact of environmental influences during critical periods of developmental plasticity can elicit lifelong effects on the physiology of the offspring. Further, evidence to date suggests that this developmental programming is a transgenerational phenomenon, with a number of studies showing transmission of programming effects to subsequent generations, even in the absence of continued environmental stressors, thus perpetuating a cycle of obesity and metabolic disorders. The mechanisms responsible for these transgenerational effects remain poorly understood; evidence to date suggests a number of potential mechanisms underpinning the transgenerational transmission of the developmentally programmed phenotype through both the maternal and paternal lineage. Transgenerational phenotype transmission is often seen as a form of epigenetic inheritance with evidence showing both germline and somatic inheritance of epigenetic modifications leading to phenotype changes across generations. However, there is also evidence for non-genomic components as well as an interaction between the developing fetus with the in utero

  13. Developmental programming: the role of growth hormone.

    Science.gov (United States)

    Oberbauer, Anita M

    2015-01-01

    Developmental programming of the fetus has consequences for physiologic responses in the offspring as an adult and, more recently, is implicated in the expression of altered phenotypes of future generations. Some phenotypes, such as fertility, bone strength, and adiposity are highly relevant to food animal production and in utero factors that impinge on those traits are vital to understand. A key systemic regulatory hormone is growth hormone (GH), which has a developmental role in virtually all tissues and organs. This review catalogs the impact of GH on tissue programming and how perturbations early in development influence GH function.

  14. Fetal growth and developmental programming.

    Science.gov (United States)

    Galjaard, Sander; Devlieger, Roland; Van Assche, Frans A

    2013-01-01

    The environment in utero and in early neonatal life may induce a permanent response in the fetus and the newborn, leading to enhanced susceptibility to later diseases. This review concentrates on the role and mechanisms of events during the antenatal and immediate postnatal period resulting in later life diseases, concentrating on abnormal growth patterns of the fetus. Fetal overgrowth is related to exposure to a diabetic intra uterine environment, increasing the vulnerability to transgenerational obesity and hence an increased sensitivity to more diabetic mothers. This effect has been supported by animal data. Fetal growth restriction is complex due to malnutrition in utero, catch up growth due to a high caloric intake and low physical activity in later life. Metabolic changes and a transgenerational effect of intra uterine malnutrition has been supported by animal data. In recent years the discovery of alterations of the genome due to different influences during embryonic life, called epigenetics, has led to the phenomenon of fetal programming resulting in changing transgenerational metabolic effects.

  15. Maternal Obesity, Inflammation, and Developmental Programming

    Directory of Open Access Journals (Sweden)

    Stephanie A. Segovia

    2014-01-01

    Full Text Available The prevalence of obesity, especially in women of child-bearing age, is a global health concern. In addition to increasing the immediate risk of gestational complications, there is accumulating evidence that maternal obesity also has long-term consequences for the offspring. The concept of developmental programming describes the process in which an environmental stimulus, including altered nutrition, during critical periods of development can program alterations in organogenesis, tissue development, and metabolism, predisposing offspring to obesity and metabolic and cardiovascular disorders in later life. Although the mechanisms underpinning programming of metabolic disorders remain poorly defined, it has become increasingly clear that low-grade inflammation is associated with obesity and its comorbidities. This review will discuss maternal metainflammation as a mediator of programming in insulin sensitive tissues in offspring. Use of nutritional anti-inflammatories in pregnancy including omega 3 fatty acids, resveratrol, curcumin, and taurine may provide beneficial intervention strategies to ameliorate maternal obesity-induced programming.

  16. Vehicle Technologies Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-09-05

    Overview of the Vehicle Technologies Program including external assessment and market view; internal assessment, program history and progress; program justification and federal role; program vision, mission, approach, strategic goals, outputs, and outcomes; and performance goals.

  17. Developmental Programming, a Pathway to Disease

    Science.gov (United States)

    Cardoso, Rodolfo C.; Puttabyatappa, Muraly

    2016-01-01

    Accumulating evidence suggests that insults occurring during the perinatal period alter the developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes that often culminate in adult pathologies. These perinatal insults include maternal/fetal disease states, nutritional deficits/excess, stress, lifestyle choices, exposure to environmental chemicals, and medical interventions. In addition to reviewing the various insults that contribute to developmental programming and the benefits of animal models in addressing underlying mechanisms, this review focuses on the commonalities in disease outcomes stemming from various insults, the convergence of mechanistic pathways via which various insults can lead to common outcomes, and identifies the knowledge gaps in the field and future directions. PMID:26859334

  18. Instructional Technology Practices in Developmental Education in Texas

    Science.gov (United States)

    Martirosyan, Nara M.; Kennon, J. Lindsey; Saxon, D. Patrick; Edmonson, Stacey L.; Skidmore, Susan T.

    2017-01-01

    The purpose of this study was to examine the current state of technology integration in developmental education in Texas higher education. Analyzing survey data from developmental education faculty members in 70 2- and 4-year colleges in Texas, researchers identified instructor-reported best instructional technology practices in developmental…

  19. Technology Commercialization Program 1991

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This reference compilation describes the Technology Commercialization Program of the Department of Energy, Defense Programs. The compilation consists of two sections. Section 1, Plans and Procedures, describes the plans and procedures of the Defense Programs Technology Commercialization Program. The second section, Legislation and Policy, identifies legislation and policy related to the Program. The procedures for implementing statutory and regulatory requirements are evolving with time. This document will be periodically updated to reflect changes and new material.

  20. SHARED TECHNOLOGY TRANSFER PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    GRIFFIN, JOHN M. HAUT, RICHARD C.

    2008-03-07

    The program established a collaborative process with domestic industries for the purpose of sharing Navy-developed technology. Private sector businesses were educated so as to increase their awareness of the vast amount of technologies that are available, with an initial focus on technology applications that are related to the Hydrogen, Fuel Cells and Infrastructure Technologies (Hydrogen) Program of the U.S. Department of Energy. Specifically, the project worked to increase industry awareness of the vast technology resources available to them that have been developed with taxpayer funding. NAVSEA-Carderock and the Houston Advanced Research Center teamed with Nicholls State University to catalog NAVSEA-Carderock unclassified technologies, rated the level of readiness of the technologies and established a web based catalog of the technologies. In particular, the catalog contains technology descriptions, including testing summaries and overviews of related presentations.

  1. A Predoctoral Program in Dental Care for the Developmentally Disabled.

    Science.gov (United States)

    Ferguson, Fred S.; And Others

    1990-01-01

    In 1980, the State University of New York at Stony Brook began a program, integrated into the program of children's dentistry, to train students in care for the developmentally disabled. Management of developmentally disabled patients is provided over three years, and represents an extension of pediatric behavior management. (MSE)

  2. Developmental programming of appetite/satiety.

    Science.gov (United States)

    Ross, Michael G; Desai, Mina

    2014-01-01

    Obesity is often attributed to a Western lifestyle, a high-fat diet and decreased activity. While these factors certainly contribute to adult obesity, compelling data from our laboratory and others indicate that this explanation is oversimplified. Recent studies strongly argue that maternal/fetal under- or overnutrition predisposes the offspring to become hyperphagic and increases the risk of later obesity. Both infants small for gestational age (SGA) or infants born to obese mothers who consume a high-fat diet are at a markedly increased risk of adult obesity. Specific alterations in the fetal metabolic/energy environment directly influence the development of appetite regulatory pathways. Specifically, SGA infants demonstrate (1) impaired satiety and anorexigenic cell signaling, (2) enhanced cellular orexigenic responses, (3) programmed dysfunction of neuroprogenitor cell proliferation/differentiation, and (4) increased expression of appetite (NPY) versus satiety (POMC) neurons. In both hypothalamic tissue and ex vivo culture, SGA newborns exhibit increased levels of the nutrient sensor SIRT1, signifying reduced energy, whereas maternal high-fat-exposed newborns exhibit reduced levels of pAMPK, signifying energy excess. Via downstream regulation of bHLH neuroproliferation (Hes1) and neurodifferentiation factors (Mash1, Ngn3), neurogenesis is biased toward orexigenic and away from anorexigenic neurons, resulting in excess appetite, reduced satiety and development of obesity. Despite the developmental programming of appetite neurogenesis, the potential for neuronal remodeling raises the opportunity for novel interventions.

  3. Geothermal Technologies Program: Alaska

    Energy Technology Data Exchange (ETDEWEB)

    2005-02-01

    This fact sheets provides a summary of geothermal potential, issues, and current development in Alaska. This fact sheet was developed as part of DOE's GeoPowering the West initiative, part of the Geothermal Technologies Program.

  4. Aberrant Recapitulation of Developmental Program: Novel Target in Scleroderma

    Science.gov (United States)

    2015-12-01

    AWARD NUMBER: W81XWH-12-1-0472 TITLE: “Aberrant Recapitulation of Developmental Program: Novel Target in Scleroderma ” PRINCIPAL INVESTIGATOR...SUBTITLE Aberrant Recapitulation of Developmental Program: Novel Target in Scleroderma 5a. CONTRACT NUMBER W81XWH-12-1-0472 5b. GRANT NUMBER 5c. PROGRAM...SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION / AVAILABILITY STATEMENT 13. SUPPLEMENTARY NOTES 14. ABSTRACT Fibrosis in scleroderma is associated

  5. Cask technology program activities

    International Nuclear Information System (INIS)

    Allen, G.C. Jr.

    1986-01-01

    The civilian waste cask technology program consists of five major activities: (1) technical issue resolution directed toward NRC and DOT concerns, (2) system concept evaluations to determine the benefits of proposals made to DOE for transportation improvements, (3) applied technology and technical data tasks that provide independent information and enhance technology transfer between cask contractors, (4) standards development and code benchmarking that provide a service to DOE and cask contractors, and (5) testing to ensure the adequacy of cask designs. The program addresses broad issues that affect several cask development contractors and areas where independent technical input could enhance the Office of Civilian Radioactive Waste Management goals

  6. Developing a Web-Based Developmental Feedback Program

    National Research Council Canada - National Science Library

    Douglas, Matthew

    2003-01-01

    Developmental feedback programs provide an opportunity to improve leadership practices by giving leaders feedback about their performance from a number of sources, This thesis expanded on Capt Doug Patton's pilot study (2002...

  7. Developmental Programming of Renal Function and Re-Programming Approaches.

    Science.gov (United States)

    Nüsken, Eva; Dötsch, Jörg; Weber, Lutz T; Nüsken, Kai-Dietrich

    2018-01-01

    Chronic kidney disease affects more than 10% of the population. Programming studies have examined the interrelationship between environmental factors in early life and differences in morbidity and mortality between individuals. A number of important principles has been identified, namely permanent structural modifications of organs and cells, long-lasting adjustments of endocrine regulatory circuits, as well as altered gene transcription. Risk factors include intrauterine deficiencies by disturbed placental function or maternal malnutrition, prematurity, intrauterine and postnatal stress, intrauterine and postnatal overnutrition, as well as dietary dysbalances in postnatal life. This mini-review discusses critical developmental periods and long-term sequelae of renal programming in humans and presents studies examining the underlying mechanisms as well as interventional approaches to "re-program" renal susceptibility toward disease. Clinical manifestations of programmed kidney disease include arterial hypertension, proteinuria, aggravation of inflammatory glomerular disease, and loss of kidney function. Nephron number, regulation of the renin-angiotensin-aldosterone system, renal sodium transport, vasomotor and endothelial function, myogenic response, and tubuloglomerular feedback have been identified as being vulnerable to environmental factors. Oxidative stress levels, metabolic pathways, including insulin, leptin, steroids, and arachidonic acid, DNA methylation, and histone configuration may be significantly altered by adverse environmental conditions. Studies on re-programming interventions focused on dietary or anti-oxidative approaches so far. Further studies that broaden our understanding of renal programming mechanisms are needed to ultimately develop preventive strategies. Targeted re-programming interventions in animal models focusing on known mechanisms will contribute to new concepts which finally will have to be translated to human application. Early

  8. Developmental Programming of Renal Function and Re-Programming Approaches

    Directory of Open Access Journals (Sweden)

    Eva Nüsken

    2018-02-01

    Full Text Available Chronic kidney disease affects more than 10% of the population. Programming studies have examined the interrelationship between environmental factors in early life and differences in morbidity and mortality between individuals. A number of important principles has been identified, namely permanent structural modifications of organs and cells, long-lasting adjustments of endocrine regulatory circuits, as well as altered gene transcription. Risk factors include intrauterine deficiencies by disturbed placental function or maternal malnutrition, prematurity, intrauterine and postnatal stress, intrauterine and postnatal overnutrition, as well as dietary dysbalances in postnatal life. This mini-review discusses critical developmental periods and long-term sequelae of renal programming in humans and presents studies examining the underlying mechanisms as well as interventional approaches to “re-program” renal susceptibility toward disease. Clinical manifestations of programmed kidney disease include arterial hypertension, proteinuria, aggravation of inflammatory glomerular disease, and loss of kidney function. Nephron number, regulation of the renin–angiotensin–aldosterone system, renal sodium transport, vasomotor and endothelial function, myogenic response, and tubuloglomerular feedback have been identified as being vulnerable to environmental factors. Oxidative stress levels, metabolic pathways, including insulin, leptin, steroids, and arachidonic acid, DNA methylation, and histone configuration may be significantly altered by adverse environmental conditions. Studies on re-programming interventions focused on dietary or anti-oxidative approaches so far. Further studies that broaden our understanding of renal programming mechanisms are needed to ultimately develop preventive strategies. Targeted re-programming interventions in animal models focusing on known mechanisms will contribute to new concepts which finally will have to be translated

  9. Developmental Programming of Renal Function and Re-Programming Approaches

    Science.gov (United States)

    Nüsken, Eva; Dötsch, Jörg; Weber, Lutz T.; Nüsken, Kai-Dietrich

    2018-01-01

    Chronic kidney disease affects more than 10% of the population. Programming studies have examined the interrelationship between environmental factors in early life and differences in morbidity and mortality between individuals. A number of important principles has been identified, namely permanent structural modifications of organs and cells, long-lasting adjustments of endocrine regulatory circuits, as well as altered gene transcription. Risk factors include intrauterine deficiencies by disturbed placental function or maternal malnutrition, prematurity, intrauterine and postnatal stress, intrauterine and postnatal overnutrition, as well as dietary dysbalances in postnatal life. This mini-review discusses critical developmental periods and long-term sequelae of renal programming in humans and presents studies examining the underlying mechanisms as well as interventional approaches to “re-program” renal susceptibility toward disease. Clinical manifestations of programmed kidney disease include arterial hypertension, proteinuria, aggravation of inflammatory glomerular disease, and loss of kidney function. Nephron number, regulation of the renin–angiotensin–aldosterone system, renal sodium transport, vasomotor and endothelial function, myogenic response, and tubuloglomerular feedback have been identified as being vulnerable to environmental factors. Oxidative stress levels, metabolic pathways, including insulin, leptin, steroids, and arachidonic acid, DNA methylation, and histone configuration may be significantly altered by adverse environmental conditions. Studies on re-programming interventions focused on dietary or anti-oxidative approaches so far. Further studies that broaden our understanding of renal programming mechanisms are needed to ultimately develop preventive strategies. Targeted re-programming interventions in animal models focusing on known mechanisms will contribute to new concepts which finally will have to be translated to human application

  10. Cask technology program activities

    International Nuclear Information System (INIS)

    Allen, G.C. Jr.

    1986-01-01

    The civilian waste cask technology program consists of five major activities: Technical issue resolution directed toward NRC and DOT concerns; system concept evaluations to determine the benefits of proposals made to DOE for transportation improvements; applied technology and technical data tasks that provide independent information and enhance technology transfer between cask contractors; standards development and code benchmarking that provide a service to DOE and cask contractors; and testing to ensure the adequacy of cask designs. This paper addresses broad issues that affect several cask development contractors and areas where independent technical input could enhance OCRWM goals

  11. Comparing two developmental applications of speech technology

    CSIR Research Space (South Africa)

    Sharma Grover, A

    2011-05-01

    Full Text Available Over the past decade applications of speech technologies for development (ST4D) have shown much potential for enabling information access and service delivery. In this paper the authors review two deployed ST4D services and posit a set of dimensions...

  12. Technologies for Self-Determination for Youth with Developmental Disabilities

    Science.gov (United States)

    Skouge, James R.; Kelly, Mary L.; Roberts, Kelly D.; Leake, David W.; Stodden, Robert A.

    2007-01-01

    This paper focuses on "technologies for voice" that are related to the self-determination of youth with developmental disabilities. The authors describe a self-determination model that values family-focused, community-referenced pedagogies employing "new media" to give voice to youth and their families. In line with the adage that a picture is…

  13. Initiating a Developmental Motor Skills Program for Identified Primary Students.

    Science.gov (United States)

    Harville, Valerie Terrill

    A physical education specialist at an elementary school in one of the fastest growing sections of the country developed and implemented a developmental motor skills program for primary school students. The program focused on: (1) developing a method of referring students for testing; (2) providing a specialized motor diagnostic test; (3) improving…

  14. Geothermal Technologies Program Overview - Peer Review Program

    Energy Technology Data Exchange (ETDEWEB)

    Milliken, JoAnn [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-06-06

    This Geothermal Technologies Program presentation was delivered on June 6, 2011 at a Program Peer Review meeting. It contains annual budget, Recovery Act, funding opportunities, upcoming program activities, and more.

  15. Economic and developmental considerations for pharmacogenomic technology.

    Science.gov (United States)

    Vernon, John A; Johnson, Scott J; Hughen, W Keener; Trujillo, Antonio

    2006-01-01

    The pharmaceutical industry's core business is the innovation, development and marketing of new drugs. Pharmacogenetic (PG) testing and technology has the potential to increase a drug's value in many ways. A critical issue for the industry is whether products in development should be teamed with genetic tests that could segment the total population into responders and non-responders. In this paper we use a cost-effectiveness framework to model the strategic decision-making considerations by pharmaceutical manufacturers as they relate to drug development and the new technology of PG (the science of using genetic markers to predict drug response). In a simple, static, one-period model we consider three drug development strategies: a drug is exclusively developed and marketed to patients with a particular genetic marker; no distinguishing among patients based on the expression of a genetic marker is made (traditional approach); and a strategy whereby a drug is marketed to patients both with and without the genetic marker but there is price discrimination between the two subpopulations. We developed three main principles: revenues under a strategy targeting only the responder subpopulation will never generate more revenue than that which could have been obtained under a traditional approach; total revenues under a targeted PG strategy will be less than that under a traditional approach but higher than a naive [corrected] view would believe them to be; and a traditional [corrected] approach will earn the same total revenues as a price discrimination strategy, assuming no intermarket arbitrage. While these principles relate to the singular (and quite narrow) consideration of drug revenues, they may nevertheless partially explain why PG is not being used as widely as was predicted several years ago when the technology first became available, especially in terms of pharmaceutical manufacturer-developed tests.

  16. Program for Critical Technologies in Breast Oncology

    Science.gov (United States)

    1999-07-01

    the tissues, and in a ethical manner that respects the patients’ rights . The Program for Critical Technologies in Breast Oncology helps address all of...diagnosis, database 15. NUMBER OF PAGES 148 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18. SECURITY CLASSIFICATION OF THIS...closer to clinical utility. Page 17 References Adida C. Crotty PL. McGrath J. Berrebi D. Diebold J. Altieri DC. Developmentally regulated

  17. Robotics Technology Development Program

    International Nuclear Information System (INIS)

    1994-02-01

    The Robotics Technology Development Program (RTDP) is a ''needs-driven'' effort. A lengthy series of presentations and discussions at DOE sites considered critical to DOE's Environmental Restoration and Waste Management (EM) Programs resulted in a clear understanding of needed robotics applications toward resolving definitive problems at the sites. A detailed analysis of the Tank Waste Retrieval (TWR), Contaminant Analysis Automation (CAA), Mixed Waste Operations (MWO), and Decontamination ampersand Dismantlement (D ampersand D). The RTDP Group realized that much of the technology development was common (Cross Cutting-CC) to each of these robotics application areas, for example, computer control and sensor interface protocols. Further, the OTD approach to the Research, Development, Demonstration, Testing, and Evaluation (RDDT ampersand E) process urged an additional organizational break-out between short-term (1--3 years) and long-term (3--5 years) efforts (Advanced Technology-AT). The RDTP is thus organized around these application areas -- TWR, CAA, MWO, D ampersand D and CC ampersand AT -- with the first four developing short-term applied robotics. An RTDP Five-Year Plan was developed for organizing the Program to meet the needs in these application areas

  18. Effect of Developmental Stimulation Program on the Developmental Measures of Toddlers

    Directory of Open Access Journals (Sweden)

    Elahe Ghayebie

    2018-04-01

    Full Text Available Background: The variability in the developmental skills is reduced after the first three years of life; therefore, it is necessary to identify and manage early developmental delays. Aim: The aim of this study was to investigate the effect of developmental stimulation program on the developmental measures of the toddlers. Method: The present randomized controlled clinical trial was conducted on 31 toddlers aged 1-3 years residing at Ali Asghar Foster Care Center within 2016-2017. Developmental interventions were carried out based on the modified guidelines of West Virginia Early Learning Standards Framework for eight weeks (three 2-hour sessions a week. The interventions included a range of age- and developmental-specific activities described in the given guidelines. Child development age was measured based on motor dimensions (i.e., gross and fine and language development (i.e., receptive and expressive before and after the intervention. The data were analyzed in SPSS software (version 11 using independent t-test and Chi-square test. Results: The mean ages of the participants in the control and intervention groups were 19.9±5.5 and 20±6.02, respectively (P=0.62. The mean ages of receptive language development (P=0.003, expressive language development (P

  19. Nuclear Technology Programs

    International Nuclear Information System (INIS)

    Harmon, J.E.

    1990-10-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period April--September 1988. These programs involve R ampersand D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions, the thermophysical properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. Another effort is concerned with examining the feasibility of substituting low-enriched for high-enriched uranium in the production of fission-product 99 Mo. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation's high-level waste repositories

  20. Nuclear Technology Programs

    Energy Technology Data Exchange (ETDEWEB)

    Harmon, J.E. (ed.)

    1990-10-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period April--September 1988. These programs involve R D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions, the thermophysical properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. Another effort is concerned with examining the feasibility of substituting low-enriched for high-enriched uranium in the production of fission-product {sup 99}Mo. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation's high-level waste repositories.

  1. Nuclear technology programs

    International Nuclear Information System (INIS)

    Harmon, J.E.

    1992-01-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period October 1989--March 1990. These programs involve R ampersand D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions, the thermophysical properties of metal fuel and blanket materials of the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. Another effort is concerned water waste stream generated in production of 2,4,6-trinitrotoluene. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation's high-level waste repositories

  2. ABC Technology Development Program

    International Nuclear Information System (INIS)

    1994-01-01

    The Accelerator-Based Conversion (ABC) facility will be designed to accomplish the following mission: 'Provide a weapon's grade plutonium disposition capability in a safe, economical, and environmentally sound manner on a prudent schedule for [50] tons of weapon's grade plutonium to be disposed on in [20] years.' This mission is supported by four major objectives: provide a reliable plutonium disposition capability within the next [15] years; provide a level of safety and of safety assurance that meets or exceeds that afforded to the public by modern commercial nuclear power plants; meet or exceed all applicable federal, state, and local regulations or standards for environmental compliance; manage the program in a cost effective manner. The ABC Technology Development Program defines the technology development activities that are required to accomplish this mission. The technology development tasks are related to the following topics: blanket system; vessel systems; reactivity control systems; heat transport system components; energy conversion systems; shutdown heat transport systems components; auxiliary systems; technology demonstrations - large scale experiments

  3. Glucocorticoids as mediators of developmental programming effects.

    Science.gov (United States)

    Khulan, Batbayar; Drake, Amanda J

    2012-10-01

    Epidemiological evidence suggests that exposure to an adverse environment in early life is associated with an increased risk of cardio-metabolic and behavioral disorders in adulthood, a phenomenon termed 'early life programming'. One major hypothesis for early life programming is fetal glucocorticoid overexposure. In animal studies, prenatal glucocorticoid excess as a consequence of maternal stress or through exogenous administration to the mother or fetus is associated with programming effects on cardiovascular and metabolic systems and on the brain. These effects can be transmitted to subsequent generations. Studies in humans provide some evidence that prenatal glucocorticoid exposure may exert similar programming effects on glucose/insulin homeostasis, blood pressure and neurodevelopment. The mechanisms by which glucocorticoids mediate these effects are unclear but may include a role for epigenetic modifications. This review discusses the evidence for glucocorticoid programming in animal models and in humans. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. Developmental Programming of Adult Disease: Reprogramming by Melatonin?

    Science.gov (United States)

    Tain, You-Lin; Huang, Li-Tung; Hsu, Chien-Ning

    2017-02-16

    Adult-onset chronic non-communicable diseases (NCDs) can originate from early life through so-called the "developmental origins of health and disease" (DOHaD) or "developmental programming". The DOHaD concept offers the "reprogramming" strategy to shift the treatment from adulthood to early life, before clinical disease is apparent. Melatonin, an endogenous indoleamine produced by the pineal gland, has pleiotropic bioactivities those are beneficial in a variety of human diseases. Emerging evidence support that melatonin is closely inter-related to other proposed mechanisms contributing to the developmental programming of a variety of chronic NCDs. Recent animal studies have begun to unravel the multifunctional roles of melatonin in many experimental models of developmental programming. Even though some progress has been made in research on melatonin as a reprogramming strategy to prevent DOHaD-related NCDs, future human studies should aim at filling the translational gap between animal models and clinical trials. Here, we review several key themes on the reprogramming effects of melatonin in DOHaD research. We have particularly focused on the following areas: mechanisms of developmental programming; the interrelationship between melatonin and mechanisms underlying developmental programming; pathophysiological roles of melatonin in pregnancy and fetal development; and insight provided by animal models to support melatonin as a reprogramming therapy. Rates of NCDs are increasing faster than anticipated all over the world. Hence, there is an urgent need to understand reprogramming mechanisms of melatonin and to translate experimental research into clinical practice for halting a growing list of DOHaD-related NCDs.

  5. Developmental stages of developmental screening: steps to implementation of a successful program.

    Science.gov (United States)

    Pinto-Martin, Jennifer A; Dunkle, Margaret; Earls, Marian; Fliedner, Dane; Landes, Cynthia

    2005-11-01

    Through the use of 2-stage screening strategies, research studies have shown that autism spectrum disorders and other developmental disabilities can now be detected reliably and with greater validity and in children as young as 18 months of age. Screening and diagnostic practices in the medical and educational arena lag far behind clinical research, however, with the average patient age at time of diagnosis being 3 to 6 years.We discuss the challenges of instituting universal developmental screening as part of pediatric care and present 2 models of existing or planned programs of early screening for autism spectrum disorder and developmental disability (1 in a community-based setting and 1 in a pediatric setting), and discuss the pros and cons of the different strategies.

  6. Developmental Programming of Adult Disease: Reprogramming by Melatonin?

    Directory of Open Access Journals (Sweden)

    You-Lin Tain

    2017-02-01

    Full Text Available Adult-onset chronic non-communicable diseases (NCDs can originate from early life through so-called the “developmental origins of health and disease” (DOHaD or “developmental programming”. The DOHaD concept offers the “reprogramming” strategy to shift the treatment from adulthood to early life, before clinical disease is apparent. Melatonin, an endogenous indoleamine produced by the pineal gland, has pleiotropic bioactivities those are beneficial in a variety of human diseases. Emerging evidence support that melatonin is closely inter-related to other proposed mechanisms contributing to the developmental programming of a variety of chronic NCDs. Recent animal studies have begun to unravel the multifunctional roles of melatonin in many experimental models of developmental programming. Even though some progress has been made in research on melatonin as a reprogramming strategy to prevent DOHaD-related NCDs, future human studies should aim at filling the translational gap between animal models and clinical trials. Here, we review several key themes on the reprogramming effects of melatonin in DOHaD research. We have particularly focused on the following areas: mechanisms of developmental programming; the interrelationship between melatonin and mechanisms underlying developmental programming; pathophysiological roles of melatonin in pregnancy and fetal development; and insight provided by animal models to support melatonin as a reprogramming therapy. Rates of NCDs are increasing faster than anticipated all over the world. Hence, there is an urgent need to understand reprogramming mechanisms of melatonin and to translate experimental research into clinical practice for halting a growing list of DOHaD-related NCDs.

  7. The CFFTP technology applications program

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    The Canadian Fusion Fuels Technology Project (CFFTP) was originally conceived as having a Technology Applications Program to help fulfill its mandate of extending and adapting existing Canadian technology for use in international fusion programs. This technology was determined to be materials, breeder technology, remote handling, health and saftey, and tritium fuel systems. The CFFTP Applications Program has done work for the STARFIRE, MARS and TFTR reactors as well as developing two computer codes for tritium fuel systems. In the future the Technology Applications Program will be involved in the Tokamak Fusion Core Experiment (TFCX) as well as work for NET, JET and Frascati

  8. Utility of Small Animal Models of Developmental Programming.

    Science.gov (United States)

    Reynolds, Clare M; Vickers, Mark H

    2018-01-01

    Any effective strategy to tackle the global obesity and rising noncommunicable disease epidemic requires an in-depth understanding of the mechanisms that underlie these conditions that manifest as a consequence of complex gene-environment interactions. In this context, it is now well established that alterations in the early life environment, including suboptimal nutrition, can result in an increased risk for a range of metabolic, cardiovascular, and behavioral disorders in later life, a process preferentially termed developmental programming. To date, most of the mechanistic knowledge around the processes underpinning development programming has been derived from preclinical research performed mostly, but not exclusively, in laboratory mouse and rat strains. This review will cover the utility of small animal models in developmental programming, the limitations of such models, and potential future directions that are required to fully maximize information derived from preclinical models in order to effectively translate to clinical use.

  9. Program Helps Design Tests Of Developmental Software

    Science.gov (United States)

    Hops, Jonathan

    1994-01-01

    Computer program called "A Formal Test Representation Language and Tool for Functional Test Designs" (TRL) provides automatic software tool and formal language used to implement category-partition method and produce specification of test cases in testing phase of development of software. Category-partition method useful in defining input, outputs, and purpose of test-design phase of development and combines benefits of choosing normal cases having error-exposing properties. Traceability maintained quite easily by creating test design for each objective in test plan. Effort to transform test cases into procedures simplified by use of automatic software tool to create cases based on test design. Method enables rapid elimination of undesired test cases from consideration and facilitates review of test designs by peer groups. Written in C language.

  10. Developmental programming, adiposity, and reproduction in ruminants.

    Science.gov (United States)

    Symonds, M E; Dellschaft, N; Pope, M; Birtwistle, M; Alagal, R; Keisler, D; Budge, H

    2016-07-01

    Although sheep have been widely adopted as an animal model for examining the timing of nutritional interventions through pregnancy on the short- and long-term outcomes, only modest programming effects have been seen. This is due in part to the mismatch in numbers of twins and singletons between study groups as well as unequal numbers of males and females. Placental growth differs between singleton and twin pregnancies which can result in different body composition in the offspring. One tissue that is especially affected is adipose tissue which in the sheep fetus is primarily located around the kidneys and heart plus the sternal/neck region. Its main role is the rapid generation of heat due to activation of the brown adipose tissue-specific uncoupling protein 1 at birth. The fetal adipose tissue response to suboptimal maternal food intake at defined stages of development differs between the perirenal abdominal and pericardial depots, with the latter being more sensitive. Fetal adipose tissue growth may be mediated in part by changes in leptin status of the mother which are paralleled in the fetus. Then, over the first month of life plasma leptin is higher in females than males despite similar adiposity, when fat is the fastest growing tissue with the sternal/neck depot retaining uncoupling protein 1, whereas other depots do not. Future studies should take into account the respective effects of fetal number and sex to provide more detailed insights into the mechanisms by which adipose and related tissues can be programmed in utero. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. NASA's Commercial Communication Technology Program

    Science.gov (United States)

    Bagwell, James W.

    1998-01-01

    Various issues associated with "NASA's Commercial Communication Technology Program" are presented in viewgraph form. Specific topics include: 1) Coordination/Integration of government program; 2) Achievement of seamless interoperable satellite and terrestrial networks; 3) Establishment of program to enhance Satcom professional and technical workforce; 4) Precompetitive technology development; and 5) Effective utilization of spectrum and orbit assets.

  12. Mars Technology Program Planetary Protection Technology Development

    Science.gov (United States)

    Lin, Ying

    2006-01-01

    The objectives of the NASA Planetary Protection program are to preserve biological and organic conditions of solar-system bodies for future scientific exploration and to protect the Earth from potential hazardous extraterrestrial contamination. As the exploration of solar system continues, NASA remains committed to the implementation of planetary protection policy and regulations. To fulfill this commitment, the Mars Technology Program (MTP) has invested in a portfolio of tasks for developing necessary technologies to meet planetary protection requirements for the next decade missions.

  13. Clean Coal Technology Programs: Program Update 2009

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-10-01

    The purpose of the Clean Coal Technology Programs: Program Update 2009 is to provide an updated status of the U.S. Department of Energy (DOE) commercial-scale demonstrations of clean coal technologies (CCT). These demonstrations have been performed under the Clean Coal Technology Demonstration Program (CCTDP), the Power Plant Improvement Initiative (PPII), and the Clean Coal Power Initiative (CCPI). Program Update 2009 provides: (1) a discussion of the role of clean coal technology demonstrations in improving the nation’s energy security and reliability, while protecting the environment using the nation’s most abundant energy resource—coal; (2) a summary of the funding and costs of the demonstrations; and (3) an overview of the technologies being demonstrated, along with fact sheets for projects that are active, recently completed, or recently discontinued.

  14. Developmental Programming: State-of-the-Science and Future Directions

    Science.gov (United States)

    Sutton, Elizabeth F.; Gilmore, L. Anne; Dunger, David B.; Heijmans, Bas T.; Hivert, Marie-France; Ling, Charlotte; Martinez, J. Alfredo; Ozanne, Susan E.; Simmons, Rebecca A.; Szyf, Moshe; Waterland, Robert A.; Redman, Leanne M.; Ravussin, Eric

    2016-01-01

    Objective On December 8–9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies. Results The overarching goal was to provide a comprehensive assessment of the state of the scientific field, to identify research gaps and opportunities for future research in order to identify and understand the mechanisms contributing to the developmental programming of health and disease. Conclusions Identifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure and the resulting tissue specific epigenetic signature were extensively discussed and are presented in this meeting summary. PMID:27037645

  15. Mars Technology Program: Planetary Protection Technology Development

    Science.gov (United States)

    Lin, Ying

    2006-01-01

    This slide presentation reviews the development of Planetary Protection Technology in the Mars Technology Program. The goal of the program is to develop technologies that will enable NASA to build, launch, and operate a mission that has subsystems with different Planetary Protection (PP) classifications, specifically for operating a Category IVb-equivalent subsystem from a Category IVa platform. The IVa category of planetary protection requires bioburden reduction (i.e., no sterilization is required) The IVb category in addition to IVa requirements: (i.e., terminal sterilization of spacecraft is required). The differences between the categories are further reviewed.

  16. Algorithmic Trading with Developmental and Linear Genetic Programming

    Science.gov (United States)

    Wilson, Garnett; Banzhaf, Wolfgang

    A developmental co-evolutionary genetic programming approach (PAM DGP) and a standard linear genetic programming (LGP) stock trading systemare applied to a number of stocks across market sectors. Both GP techniques were found to be robust to market fluctuations and reactive to opportunities associated with stock price rise and fall, with PAMDGP generating notably greater profit in some stock trend scenarios. Both algorithms were very accurate at buying to achieve profit and selling to protect assets, while exhibiting bothmoderate trading activity and the ability to maximize or minimize investment as appropriate. The content of the trading rules produced by both algorithms are also examined in relation to stock price trend scenarios.

  17. Online Information Technologies Certificate Program

    Directory of Open Access Journals (Sweden)

    Erman YUKSELTURK

    2005-01-01

    Full Text Available Online Information Technologies Certificate Program Res. Ass. Erman YUKSELTURK Middle East Technical University Department of Computer Education and Instructional Technology, Faculty of Education, Ankara, TURKEY ABSTRACT In this study, Information Technologies Certificate Program which is based on synchronous and asynchronous communication methods over the Internet offered by cooperation of Middle East Technical University, Computer Engineering Department and Continuing Education Center were examined. This online certificate program started in May 1998 and it is still active. The program includes eight fundamental courses of Computer Engineering Department and comprised of four semesters lasting totally nine months. The main aim of this program is to train the participants in IT field to meet demand in the field of computer technologies in Turkey. As a conclusion, the properties of this program were discussed in a detailed way.

  18. Developmental programming of cardiovascular disease by prenatal hypoxia.

    Science.gov (United States)

    Giussani, D A; Davidge, S T

    2013-10-01

    It is now recognized that the quality of the fetal environment during early development is important in programming cardiovascular health and disease in later life. Fetal hypoxia is one of the most common consequences of complicated pregnancies worldwide. However, in contrast to the extensive research effort on pregnancy affected by maternal nutrition or maternal stress, the contribution of pregnancy affected by fetal chronic hypoxia to developmental programming is only recently becoming delineated and established. This review discusses the increasing body of evidence supporting the programming of cardiac susceptibility to ischaemia and reperfusion (I/R) injury, of endothelial dysfunction in peripheral resistance circulations, and of indices of the metabolic syndrome in adult offspring of hypoxic pregnancy. An additional focus of the review is the identification of plausible mechanisms and the implementation of maternal and early life interventions to protect against adverse programming.

  19. Perceived Mentoring Practices in Developmental-Behavioral Pediatrics Fellowship Programs.

    Science.gov (United States)

    Diekroger, Elizabeth A; Reyes, Charina; Myers, Katherine M; Li, Hong; Kralovic, Shanna K; Roizen, Nancy

    2017-05-01

    Junior physicians describe mentoring relationships as integral to their career development and success. Current evidence suggests that mentoring is under-utilized despite interest from trainees. The purpose of this study is to describe the mentoring practices in developmental-behavioral pediatric (DBP) fellowship programs and identify mentoring needs of DBP fellows and recent graduates. DBP fellows and recent graduates less than 5 years out of training from US-based DBP fellowship programs were contacted to complete a survey on their mentoring experiences in fellowship and early career. A total of 90 respondents completed the entire survey including 47 current DBP fellows and 43 recent graduates. Only 52% of respondents reported having a formal faculty mentor during their fellowship. Only 45% of recent graduates reported that they currently have a mentor, of those without a current mentor 83% said they would like to have a mentor. Adequate mentoring during fellowship was lowest for career development and research (34% and 27%). Satisfaction with mentoring was associated with having a formal mentor (p mentoring in multiple areas (p mentoring addresses the mentee's career goals, provides insight into being a developmental-behavioral pediatrician, assists in navigating academics, and involves a personal relationship. Results suggest opportunities for improved mentoring in DBP fellowship programs, particularly in the areas of career development and research and that there is a significant need for mentorship among recent graduates. Findings from this study can inform program improvement in mentoring for DBP fellows and recent graduates.

  20. Reproduction Symposium: developmental programming of reproductive and metabolic health.

    Science.gov (United States)

    Padmanabhan, V; Veiga-Lopez, A

    2014-08-01

    Inappropriate programming of the reproductive system by developmental exposure to excess steroid hormones is of concern. Sheep are well suited for investigating developmental origin of reproductive and metabolic disorders. The developmental time line of female sheep (approximately 5 mo gestation and approximately 7 mo to puberty) is ideal for conducting sequential studies of the progression of metabolic and/or reproductive disruption from the developmental insult to manifestation of adult consequences. Major benefits of using sheep include knowledge of established critical periods to target adult defects, a rich understanding of reproductive neuroendocrine regulation, availability of noninvasive approaches to monitor follicular dynamics, established surgical approaches to obtain hypophyseal portal blood for measurement of hypothalamic hormones, and the ability to perform studies in natural setting thereby keeping behavioral interactions intact. Of importance is the ability to chronically instrument fetus and mother for determining early endocrine perturbations. Prenatal exposure of the female to excess testosterone (T) leads to an array of adult reproductive disorders that include LH excess, functional hyperandrogenism, neuroendocrine defects, multifollicular ovarian morphology, and corpus luteum dysfunction culminating in early reproductive failure. At the neuroendocrine level, all 3 feedback systems are compromised. At the pituitary level, gonadotrope (LH secretion) sensitivity to GnRH is increased. Multifollicular ovarian morphology stems from persistence of follicles as well as enhanced follicular recruitment. These defects culminate in progressive loss of cyclicity and reduced fecundity. Prenatal T excess also leads to fetal growth retardation, an early marker of adult reproductive and metabolic diseases, insulin resistance, hypertension, and behavioral deficits. Collectively, the reproductive and metabolic deficits of prenatal T-treated sheep provide proof of

  1. Developmental programming of reproductive and metabolic health1,2

    Science.gov (United States)

    Padmanabhan, V.; Veiga-Lopez, A.

    2014-01-01

    The inappropriate programming of the reproductive system by developmental exposure to excess steroid hormones is of concern. Sheep are well suited for investigating developmental origin of reproductive and metabolic disorders. The developmental time line of female sheep (~5 mo gestation and ~7 mo to puberty) is ideal for conducting sequential studies of the progression of metabolic and (or) reproductive disruption from the developmental insult to manifestation of adult consequences. Major benefits of using sheep include knowledge of established critical periods to target adult defects, a rich understanding of reproductive neuroendocrine regulation, availability of non-invasive approaches to monitor follicular dynamics, established surgical approaches to obtain hypophyseal portal blood for measurement of hypothalamic hormones, and the ability to perform studies in natural setting keeping behavioral interactions intact. Of importance is the ability to chronically instrument fetus and mother for determining early endocrine perturbations. Prenatal exposure of the female to excess testosterone (T) leads to an array of adult reproductive disorders that include LH excess, functional hyperandrogenism, neuroendocrine defects, multifollicular ovarian morphology, and corpus luteum dysfunction culminating in early reproductive failure. At the neuroendocrine level all three feedback systems are compromised. At the pituitary level, gonadotrope (LH secretion) sensitivity to GnRH is increased. Multifollicular ovarian morphology stems from persistence of follicles, as well as enhanced follicular recruitment. These defects culminate in progressive loss of cyclicity and reduced fecundity. Prenatal T excess also leads to fetal growth retardation, an early marker of adult reproductive/metabolic diseases, insulin resistance, hypertension and behavioral deficits. Collectively, the reproductive and metabolic deficits of prenatal T-treated sheep provide proof of concept for the

  2. Developmental Relationship Programs: An Empirical Study of the Impact of Peer-Mentoring Programs

    Science.gov (United States)

    Shojai, Siamack; Davis, William J.; Root, Patricia S.

    2014-01-01

    This paper provides an empirical analysis of the impact and effectiveness of developmental relationships provided through academic intervention programs at a medium-size master's level public university in the Northeastern United States. The programs' curriculum follows the Model of Strategic Learning's four pillars of learning and is administered…

  3. Reusable Launch Vehicle Technology Program

    Science.gov (United States)

    Freeman, Delma C., Jr.; Talay, Theodore A.; Austin, R. Eugene

    1997-01-01

    Industry/NASA reusable launch vehicle (RLV) technology program efforts are underway to design, test, and develop technologies and concepts for viable commercial launch systems that also satisfy national needs at acceptable recurring costs. Significant progress has been made in understanding the technical challenges of fully reusable launch systems and the accompanying management and operational approaches for achieving a low cost program. This paper reviews the current status of the RLV technology program including the DC-XA, X-33 and X-34 flight systems and associated technology programs. It addresses the specific technologies being tested that address the technical and operability challenges of reusable launch systems including reusable cryogenic propellant tanks, composite structures, thermal protection systems, improved propulsion and subsystem operability enhancements. The recently concluded DC-XA test program demonstrated some of these technologies in ground and flight test. Contracts were awarded recently for both the X-33 and X-34 flight demonstrator systems. The Orbital Sciences Corporation X-34 flight test vehicle will demonstrate an air-launched reusable vehicle capable of flight to speeds of Mach 8. The Lockheed-Martin X-33 flight test vehicle will expand the test envelope for critical technologies to flight speeds of Mach 15. A propulsion program to test the X-33 linear aerospike rocket engine using a NASA SR-71 high speed aircraft as a test bed is also discussed. The paper also describes the management and operational approaches that address the challenge of new cost effective, reusable launch vehicle systems.

  4. Geothermal Technologies Program: Direct Use

    Energy Technology Data Exchange (ETDEWEB)

    2004-08-01

    This general publication describes geothermal direct use systems, and how they have been effectively used throughout the country. It also describes the DOE program R&D efforts in this area, and summarizes several projects using direct use technology.

  5. Photovoltaics technology program summary

    Science.gov (United States)

    1985-05-01

    An adequate supply of energy at reasonable price is discussed. Economic efficiency and the following strategies to obtain it are suggested: (1) minimization of federal regulation in energy pricing; and (2) promote a balanced and mixed energy resource system. The development of photovoltaic energy conversion technology is summarized.

  6. Robotics Technology Crosscutting Program. Technology summary

    International Nuclear Information System (INIS)

    1995-06-01

    The Robotics Technology Development Program (RTDP) is a needs-driven effort. A length series of presentations and discussions at DOE sites considered critical to DOE's Environmental Restoration and Waste Management (EM) Programs resulted in a clear understanding of needed robotics applications toward resolving definitive problems at the sites. A detailed analysis of the resulting robotics needs assessment revealed several common threads running through the sites: Tank Waste Retrieval (TWR), Contaminant Analysis Automation (CAA), Mixed Waste Operations (MWO), and Decontamination and Dismantlement (D and D). The RTDP Group also realized that some of the technology development in these four areas had common (Cross Cutting-CC) needs, for example, computer control and sensor interface protocols. Further, the OTD approach to the Research, Development, Demonstration, Testing, and Evaluation (RDDT and E) process urged an additional organizational breakdown between short-term (1--3 years) and long-term (3--5 years) efforts (Advanced Technology-AT). These factors lead to the formation of the fifth application area for Crosscutting and Advanced Technology (CC and AT) development. The RTDP is thus organized around these application areas -- TWR, CAA, MWO, D and D, and CC and AT -- with the first four developing short-term applied robotics. An RTDP Five-Year Plan was developed for organizing the Program to meet the needs in these application areas

  7. Robotics Technology Crosscutting Program. Technology summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The Robotics Technology Development Program (RTDP) is a needs-driven effort. A length series of presentations and discussions at DOE sites considered critical to DOE`s Environmental Restoration and Waste Management (EM) Programs resulted in a clear understanding of needed robotics applications toward resolving definitive problems at the sites. A detailed analysis of the resulting robotics needs assessment revealed several common threads running through the sites: Tank Waste Retrieval (TWR), Contaminant Analysis Automation (CAA), Mixed Waste Operations (MWO), and Decontamination and Dismantlement (D and D). The RTDP Group also realized that some of the technology development in these four areas had common (Cross Cutting-CC) needs, for example, computer control and sensor interface protocols. Further, the OTD approach to the Research, Development, Demonstration, Testing, and Evaluation (RDDT and E) process urged an additional organizational breakdown between short-term (1--3 years) and long-term (3--5 years) efforts (Advanced Technology-AT). These factors lead to the formation of the fifth application area for Crosscutting and Advanced Technology (CC and AT) development. The RTDP is thus organized around these application areas -- TWR, CAA, MWO, D and D, and CC and AT -- with the first four developing short-term applied robotics. An RTDP Five-Year Plan was developed for organizing the Program to meet the needs in these application areas.

  8. 47 CFR 22.409 - Developmental authorization for a new Public Mobile Service or technology.

    Science.gov (United States)

    2010-10-01

    ... Mobile Service or technology. 22.409 Section 22.409 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Developmental Authorizations § 22.409 Developmental authorization for a new Public Mobile Service or technology. The FCC may grant applications for...

  9. NASA energy technology applications program

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-05

    The NASA Energy Technology Applications Program is reviewed. This program covers the following points: 1. wind generation of electricity; 2. photovoltaic solar cells; 3. satellite power systems; 4. direct solar heating and cooling; 5. solar thermal power plants; 6. energy storage; 7. advanced ground propulsion; 8. stationary on-site power supply; 9. advanced coal extraction; 10. magnetic heat pump; 11. aeronautics.

  10. Civil Engineering Technology Program Guide.

    Science.gov (United States)

    Georgia Univ., Athens. Dept. of Vocational Education.

    This program guide presents civil engineering technology curriculum for technical institutes in Georgia. The general information section contains the following: purpose and objectives; program description, including admissions, typical job titles, and accreditation and certification; and curriculum model, including standard curriculum sequence and…

  11. The Effects of a Developmentally Appropriate Music and Movement Program on Motor Performance

    Science.gov (United States)

    Zachopoulou, E.; Tsapakidou, A.; Derri, V.

    2004-01-01

    Basic motor skills development is achieved through the implementation of different types of physical education programs. The purpose of this study was to investigate and to compare the effect of a developmentally appropriate music and movement program and of a developmentally appropriate physical education program on the development of jumping and…

  12. Student supports: developmental education and other academic programs.

    Science.gov (United States)

    Bettinger, Eric P; Boatman, Angela; Long, Bridget Terry

    2013-01-01

    Low rates of college completion are a major problem in the United States. Less than 60 percent of students at four-year colleges graduate within six years, and at some colleges, the graduation rate is less than 10 percent. Additionally, many students enter higher education ill-prepared to comprehend college-level course material. Some estimates suggest that only one-third of high school graduates finish ready for college work; the proportion is even lower among older students. Colleges have responded to the poor preparation of incoming students by placing approximately 35 to 40 percent of entering freshmen into remedial or developmental courses, along with providing academic supports such as summer bridge programs, learning communities, academic counseling, and tutoring, as well as student supports such as financial aid and child care. Eric Bettinger, Angela Boatman, and Bridget Terry Long describe the role, costs, and impact of these college remediation and academic support programs. According to a growing body of research, the effects of remedial courses are considerably nuanced. The courses appear to help or hinder students differently by state, institution, background, and academic preparedness. The mixed findings from earlier research have raised questions ranging from whether remedial programs, on average, improve student academic outcomes to which types of programs are most effective. Administrators, practitioners, and policy makers are responding by redesigning developmental courses and searching for ways to implement effective remediation programs more broadly. In addition, recent research suggests that colleges may be placing too many students into remedial courses unnecessarily, suggesting the need for further examining the placement processes used to assign students to remedial courses. The authors expand the scope of remediation research by discussing other promising areas of academic support commonly offered by colleges, including advising, tutoring

  13. Robotics crosscutting program: Technology summary

    International Nuclear Information System (INIS)

    1996-08-01

    The Office of Environmental Management (EM) is responsible for cleaning up the legacy of radioactive and chemically hazardous waste at contaminated sites and facilities throughout the U.S. Department of Energy (DOE) nuclear weapons complex, preventing further environmental contamination, and instituting responsible environmental management. Initial efforts to achieve this mission resulted in the establishment of environmental restoration and waste management programs. However, as EM began to execute its responsibilities, decision makers became aware that the complexity and magnitude of this mission could not be achieved efficiently, affordably, safely, or reasonably with existing technology. Once the need for advanced cleanup technologies became evident, EM established an aggressive, innovative program of applied research and technology development. The Office of Technology Development (OTD) was established in November 1989 to advance new and improved environmental restoration and waste management technologies that would reduce risks to workers, the public, and the environment; reduce cleanup costs; and devise methods to correct cleanup problems that currently have no solutions. In 1996, OTD added two new responsibilities - management of a Congressionally mandated environmental science program and development of risk policy, requirements, and guidance. OTD was renamed the Office of Science and Technology (OST). This documents presents information concerning robotics tank waste retrieval overview, robotic chemical analysis automation, robotics decontamination and dismantlement, and robotics crosscutting and advanced technology

  14. Pollution Prevention Program: Technology summary

    International Nuclear Information System (INIS)

    1994-02-01

    The Department of Energy (DOE) has established a national Research, Development, Demonstration, Testing, and Evaluation (RDDT ampersand E) Program for pollution prevention and waste minimization at its production plants During FY89/90 the Office of Environmental Restoration and Waste Management (EM), through the Office of Technology Development (OTD), established comprehensive, pollution prevention technical support programs to demonstrate new, environmentally-conscious technology for production processes. The RDDT ampersand E program now entails collaborative efforts across DOE. The Pollution Prevention Program is currently supporting three major activities: The DOE/US Air Force Memorandum of Understanding Program is a collaborative effort to utilize the combined resources of DOE and the Department of Defense, eliminate duplication of effort in developing technologies, and to facilitate technology solutions aimed at reducing waste through process modification, material substitution or recycling. The Waste Component Recycle, Treatment and Disposal Integrated Demonstration (WeDID) will develop recycle, treatment, and disposal processes and associated technologies for use in the dismantlement of non-nuclear weapons components, to support US arms treaties and policies. This program will focus on meeting all security and regulatory requirements (with additional benefit to the commercial electronics industry). The Environmentally Conscious Manufacturing Integrated Demonstration (ECMID) will effectively implement ECM technologies that address both the needs of the DOE Complex and US electronics industry, and encourage strong interaction between DOE and US industry. The ECMID will also develop life cycle analysis tools that will aid decisionmakers in selecting the optimum process based on the tradeoffs between cost an environmental impact

  15. Family Members' Reports of the Technology Use of Family Members with Intellectual and Developmental Disabilities

    Science.gov (United States)

    Palmer, S. B.; Wehmeyer, M. L.; Davies, D. K.; Stock, S. E.

    2012-01-01

    Background: A nationwide survey of family members of people with intellectual and developmental disabilities ranging in age from birth through adulthood was conducted to replicate a similar effort by Wehmeyer and update the knowledge base concerning technology use by people with intellectual and developmental disabilities. Method: Survey responses…

  16. Maternal perinatal diet induces developmental programming of bone architecture.

    Science.gov (United States)

    Devlin, M J; Grasemann, C; Cloutier, A M; Louis, L; Alm, C; Palmert, M R; Bouxsein, M L

    2013-04-01

    Maternal high-fat (HF) diet can alter offspring metabolism via perinatal developmental programming. This study tests the hypothesis that maternal HF diet also induces perinatal programming of offspring bone mass and strength. We compared skeletal acquisition in pups from C57Bl/6J mice fed HF or normal diet from preconception through lactation. Three-week-old male and female pups from HF (HF-N) and normal mothers (N-N) were weaned onto normal diet. Outcomes at 14 and 26 weeks of age included body mass, body composition, whole-body bone mineral content (WBBMC) via peripheral dual-energy X-ray absorptiometry, femoral cortical and trabecular architecture via microcomputed tomography, and glucose tolerance. Female HF-N had normal body mass and glucose tolerance, with lower body fat (%) but higher serum leptin at 14 weeks vs. N-N (Pbone volume fraction was 20% higher at 14 weeks in female HF-N vs. N-N (Pbone area was 6% higher at 14 weeks vs. N-N (Pbone, supporting the hypothesis that maternal diet alters postnatal skeletal homeostasis.

  17. HTGR generic technology program plan (FY 80)

    International Nuclear Information System (INIS)

    1980-01-01

    Purpose of the program is to develop base technology and to perform design and development common to the HTGR Steam Cycle, Gas Turbine, and Process Heat Plants. The generic technology program breaks into the base technology, generic component, pebble-bed study, technology transfer, and fresh fuel programs

  18. Doctoral Programs in Developmental Education: Interview with Three Leaders

    Science.gov (United States)

    Kincaid, Marla

    2013-01-01

    Marla Kincaid (Adjunct Instructor, Austin Community College M.A., Developmental Education Department of Curriculum and Instruction Texas State University-San Marcos) interviewed the following leaders in the field of Developmental Education: (1) Dr. Olatunde Ogunyemi, Professor in the Department of Educational Leadership at Grambling State…

  19. Dietary Proteins, Developmental Programming, and Potential Implication in Maternal Obesity

    Directory of Open Access Journals (Sweden)

    Alireza Jahan-mihan

    2017-08-01

    Full Text Available Background: Proteins are known mainly based on their metabolic and nutritional functions including protein synthesis and a source of energy. In spite of various physiological properties attributed to proteins, their functions have neither been addressed by assessing quality of proteins nor by nutrition and dietetic practices. Methods: Studies were included if they were randomized animal studies, clinical trials and systematic reviews/meta-analysis published in English language. Results: The effect of maternal diet in general and dietary proteins in particular during development on health of offspring has been well-studied. Protein content as well as source of protein in the diet consumed during pregnancy and lactation influenced the risk of metabolic syndrome characteristics in offspring. Both high and low protein diets showed detrimental effects on health of offspring. Moreover, comparison of maternal casein-based diet with soy protein-based diet showed more favorable effect on body weight, body composition, blood pressure, and glucose metabolism in offspring. However, the role of maternal dietary proteins in developing the risk of metabolic syndrome characteristics in offspring in gestational obesity is still unclear and needs further study. Conclusions: Dietary proteins are determining factors in developmental programming. Both quantity and source of proteins in maternal diet influenced the development of metabolic syndrome characteristics in offspring. However, whether they have the same function in presence of gestational obesity is still unclear and needs further study.

  20. A genome resource to address mechanisms of developmental programming: determination of the fetal sheep heart transcriptome.

    Science.gov (United States)

    Cox, Laura A; Glenn, Jeremy P; Spradling, Kimberly D; Nijland, Mark J; Garcia, Roy; Nathanielsz, Peter W; Ford, Stephen P

    2012-06-15

    The pregnant sheep has provided seminal insights into reproduction related to animal and human development (ovarian function, fertility, implantation, fetal growth, parturition and lactation). Fetal sheep physiology has been extensively studied since 1950, contributing significantly to the basis for our understanding of many aspects of fetal development and behaviour that remain in use in clinical practice today. Understanding mechanisms requires the combination of systems approaches uniquely available in fetal sheep with the power of genomic studies. Absence of the full range of sheep genomic resources has limited the full realization of the power of this model, impeding progress in emerging areas of pregnancy biology such as developmental programming. We have examined the expressed fetal sheep heart transcriptome using high-throughput sequencing technologies. In so doing we identified 36,737 novel transcripts and describe genes, gene variants and pathways relevant to fundamental developmental mechanisms. Genes with the highest expression levels and with novel exons in the fetal heart transcriptome are known to play central roles in muscle development. We show that high-throughput sequencing methods can generate extensive transcriptome information in the absence of an assembled and annotated genome for that species. The gene sequence data obtained provide a unique genomic resource for sheep specific genetic technology development and, combined with the polymorphism data, augment annotation and assembly of the sheep genome. In addition, identification and pathway analysis of novel fetal sheep heart transcriptome splice variants is a first step towards revealing mechanisms of genetic variation and gene environment interactions during fetal heart development.

  1. Role of the pre- and post-natal environment in developmental programming of health and productivity.

    Science.gov (United States)

    Reynolds, Lawrence P; Caton, Joel S

    2012-05-06

    The concept that developmental insults (for example, poor pre- or postnatal nutrition) can have long-term consequences on health and well-being of the offspring has been termed developmental programming. In livestock, developmental programming affects production traits, including growth, body composition, and reproduction. Although low birth weight was used as a proxy for compromised fetal development in the initial epidemiological studies, based on controlled studies using livestock and other animal models in the last two decades we now know that developmental programming can occur independently of any effects on birth weight. Studies in humans, rodents, and livestock also have confirmed the critical role of the placenta in developmental programming. In addition, the central role of epigenetic regulation in developmental programming has been confirmed. Lastly, relatively simple therapeutic/management strategies designed to 'rescue' placental development and function are being developed to minimize the effects of developmental programming on health and productivity of humans, livestock, and other mammals. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  2. 77 FR 48995 - Draft National Toxicology Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes...

    Science.gov (United States)

    2012-08-15

    ... Program (NTP) Monograph on Developmental Effects and Pregnancy Outcomes Associated With Cancer... the panel completes its peer review of the draft monograph. Topic: Peer review of the draft NTP Monograph on Developmental Effects and Pregnancy Outcomes Associated with Cancer Chemotherapy Use during...

  3. Developmental Programming of Adult Disease: Reprogramming by Melatonin?

    OpenAIRE

    Tain, You-Lin; Huang, Li-Tung; Hsu, Chien-Ning

    2017-01-01

    Adult-onset chronic non-communicable diseases (NCDs) can originate from early life through so-called the “developmental origins of health and disease” (DOHaD) or “developmental programming”. The DOHaD concept offers the “reprogramming” strategy to shift the treatment from adulthood to early life, before clinical disease is apparent. Melatonin, an endogenous indoleamine produced by the pineal gland, has pleiotropic bioactivities those are beneficial in a variety of human diseases. Emerging evi...

  4. Network speech systems technology program

    Science.gov (United States)

    Weinstein, C. J.

    1981-09-01

    This report documents work performed during FY 1981 on the DCA-sponsored Network Speech Systems Technology Program. The two areas of work reported are: (1) communication system studies in support of the evolving Defense Switched Network (DSN) and (2) design and implementation of satellite/terrestrial interfaces for the Experimental Integrated Switched Network (EISN). The system studies focus on the development and evaluation of economical and endurable network routing procedures. Satellite/terrestrial interface development includes circuit-switched and packet-switched connections to the experimental wideband satellite network. Efforts in planning and coordination of EISN experiments are reported in detail in a separate EISN Experiment Plan.

  5. Community Based Competitive Employment Preparation of Developmentally Disabled Persons: A Program Description and Evaluation.

    Science.gov (United States)

    Stodden, Robert A.; Browder, Phyllis Meighen

    1986-01-01

    Success in competitive employment placement of a demonstration project serving 53 persons with developmental disabilities is associated with three factors: (1) training approach and methodology; (2) program management; and (3) trainee characteristics. (CL)

  6. Moving beyond Screen Time: Redefining Developmentally Appropriate Technology Use in Early Childhood Education. Policy Brief

    Science.gov (United States)

    Daugherty, Lindsay; Dossani, Rafiq; Johnson, Erin-Elizabeth; Wright, Cameron

    2014-01-01

    Conversations about what constitutes "developmentally appropriate" use of technology in early childhood education have, to date, focused largely on a single, blunt measure--screen time--that fails to capture important nuances, such as what type of media a child is accessing and whether technology use is taking place solo or with peers.…

  7. Clean Coal Technology Demonstration Program: Program Update 1998

    Energy Technology Data Exchange (ETDEWEB)

    Assistant Secretary for Fossil Energy

    1999-03-01

    Annual report on the Clean Coal Technology Demonstration Program (CCT Program). The report address the role of the CCT Program, implementation, funding and costs, accomplishments, project descriptions, legislative history, program history, environmental aspects, and project contacts. The project descriptions describe the technology and provides a brief summary of the demonstration results.

  8. Clean Coal Technology Demonstration Program: Program Update 2001

    Energy Technology Data Exchange (ETDEWEB)

    Assistant Secretary for Fossil Energy

    2002-07-30

    Annual report on the Clean Coal Technology Demonstration Program (CCT Program). The report address the role of the CCT Program, implementation, funding and costs, accomplishments, project descriptions, legislative history, program history, environmental aspects, and project contacts. The project descriptions describe the technology and provides a brief summary of the demonstration results. Also includes Power Plant Improvement Initiative Projects.

  9. Developmental block and programmed cell death in Bos indicus embryos: effects of protein supplementation source and developmental kinetics.

    Directory of Open Access Journals (Sweden)

    Sheila Merlo Garcia

    Full Text Available The aims of this study were to determine if the protein source of the medium influences zebu embryo development and if developmental kinetics, developmental block and programmed cell death are related. The culture medium was supplemented with either fetal calf serum or bovine serum albumin. The embryos were classified as Fast (n = 1,235 or Slow (n = 485 based on the time required to reach the fourth cell cycle (48 h and 90 h post insemination - hpi -, respectively. The Slow group was further separated into two groups: those presenting exactly 4 cells at 48 hpi (Slow/4 cells and those that reached the fourth cell cycle at 90 hpi (Slow. Blastocyst quality, DNA fragmentation, mitochondrial membrane potential and signs of apoptosis or necrosis were evaluated. The Slow group had higher incidence of developmental block than the Fast group. The embryos supplemented with fetal calf serum had lower quality. DNA fragmentation and mitochondrial membrane potential were absent in embryos at 48 hpi but present at 90 hpi. Early signs of apoptosis were more frequent in the Slow and Slow/4 cell groups than in the Fast group. We concluded that fetal calf serum reduces blastocyst development and quality, but the mechanism appears to be independent of DNA fragmentation. The apoptotic cells detected at 48 hpi reveal a possible mechanism of programmed cell death activation prior to genome activation. The apoptotic cells observed in the slow-developing embryos suggested a relationship between programmed cell death and embryonic developmental kinetics in zebu in vitro-produced embryos.

  10. Building Technologies Program Multi-Year Program Plan Technology Validation and Market Introduction 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for technology validation and market introduction, including ENERGY STAR, building energy codes, technology transfer application centers, commercial lighting initiative, EnergySmart Schools, EnergySmar

  11. Developmental Idealism: The Cultural Foundations of World Development Programs

    Science.gov (United States)

    Thornton, Arland; Dorius, Shawn F.; Swindle, Jeffrey

    2015-01-01

    This paper extends theory and research concerning cultural models of development beyond family and demographic matters to a broad range of additional factors, including government, education, human rights, daily social conventions, and religion. Developmental idealism is a cultural model—a set of beliefs and values—that identifies the appropriate goals of development and the ends for achieving these goals. It includes beliefs about positive cause and effect relationships among such factors as economic growth, educational achievement, health, and political governance, as well as strong values regarding many attributes, including economic growth, education, small families, gender equality, and democratic governance. This cultural model has spread from its origins among the elites of northwest Europe to elites and ordinary people throughout the world. Developmental idealism has become so entrenched in local, national, and global social institutions that it has now achieved a taken-for-granted status among many national elites, academics, development practitioners, and ordinary people around the world. We argue that developmental idealism culture has been a fundamental force behind many cultural clashes within and between societies, and continues to be an important cause of much global social change. We suggest that developmental idealism should be included as a causal factor in theories of human behavior and social change. PMID:26457325

  12. Root developmental programs shape the Medicago truncatula nodule meristem

    NARCIS (Netherlands)

    Franssen, H.; Xiao, T.T.; Kulikova, O.; Wan, X.; Bisseling, T.; Scheres, B.; Heidstra, R.

    2015-01-01

    Nodules on the roots of legume plants host nitrogen-fixing Rhizobium bacteria. Several lines of evidence indicate that nodules are evolutionarily related to roots. We determined whether developmental control of the Medicago truncatula nodule meristem bears resemblance to that in root meristems

  13. ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM: GREEN BUILDING TECHNOLOGIES

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) Program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This techno...

  14. Developmental programming: the concept, large animal models, and the key role of uteroplacental vascular development.

    Science.gov (United States)

    Reynolds, L P; Borowicz, P P; Caton, J S; Vonnahme, K A; Luther, J S; Hammer, C J; Maddock Carlin, K R; Grazul-Bilska, A T; Redmer, D A

    2010-04-01

    Developmental programming refers to the programming of various bodily systems and processes by a stressor of the maternal system during pregnancy or during the neonatal period. Such stressors include nutritional stress, multiple pregnancy (i.e., increased numbers of fetuses in the gravid uterus), environmental stress (e.g., high environmental temperature, high altitude, prenatal steroid exposure), gynecological immaturity, and maternal or fetal genotype. Programming refers to impaired function of numerous bodily systems or processes, leading to poor growth, altered body composition, metabolic dysfunction, and poor productivity (e.g., poor growth, reproductive dysfunction) of the offspring throughout their lifespan and even across generations. A key component of developmental programming seems to be placental dysfunction, leading to altered fetal growth and development. We discuss various large animal models of developmental programming and how they have and will continue to contribute to our understanding of the mechanisms underlying altered placental function and developmental programming, and, further, how large animal models also will be critical to the identification and application of therapeutic strategies that will alleviate the negative consequences of developmental programming to improve offspring performance in livestock production and human medicine.

  15. Using Technology to Enhance an Automotive Program

    Science.gov (United States)

    Ashton, Denis

    2009-01-01

    Denis Ashton uses technology in his automotive technology program at East Valley Institute of Technology (EVIT) to positively impact student outcomes. Ashton, the department chair for the automotive programs at EVIT, in Mesa, Arizona, says that using an interactive PowerPoint curriculum makes learning fun for students and provides immediate…

  16. 75 FR 1591 - Green Technology Pilot Program

    Science.gov (United States)

    2010-01-12

    ... DEPARTMENT OF COMMERCE Patent and Trademark Office Green Technology Pilot Program ACTION: Proposed... methods: E-mail: [email protected] . Include A0651-0062 Green Technology Pilot Program [email protected] in... (USPTO) is implementing a streamlined examination pilot program for patent applications pertaining to...

  17. 75 FR 64692 - Green Technology Pilot Program

    Science.gov (United States)

    2010-10-20

    ... DEPARTMENT OF COMMERCE Patent and Trademark Office Green Technology Pilot Program ACTION: Proposed...- 0062 Green Technology Pilot Program comment'' in the subject line of the message. Fax: 571-273-0112... United States Patent and Trademark Office (USPTO) implemented a pilot program on December 8, 2009, that...

  18. Clean Coal Technology Programs: Program Update 2003 (Volume 1)

    Energy Technology Data Exchange (ETDEWEB)

    Assistant Secretary for Fossil Energy

    2003-12-01

    Annual report on the Clean Coal Technology Demonstration Program (CCTDP), Power Plant Improvement Initiative (PPII), and Clean Coal Power Initiative (CCPI). The report addresses the roles of the programs, implementation, funding and costs, project descriptions, legislative history, program history, environmental aspects, and project contacts. The project descriptions describe the technology and provides a brief summary of the demonstration results.

  19. Free piston space Stirling technology program

    Science.gov (United States)

    Dochat, G. R.; Dhar, M.

    1989-01-01

    MTI recently completed an initial technology feasibility program for NASA by designing, fabricating and testing a space power demonstrator engine (SPDE). This program, which confirms the potential of free-piston Stirling engines, provided the major impetus to initiate a free-piston Stirling space engine (SSE) technology program. The accomplishments of the SPDE program are reviewed, and an overview of the SSE technology program and technical status to date is provided. It is shown that progress in both programs continues to justify its potential for either nuclear or solar space power missions.

  20. THE ENVIRONMENTAL TECHNOLOGIES ACCEPTANCE (ETA) PROGRAM

    International Nuclear Information System (INIS)

    Behr-Andres, Christina B.

    2001-01-01

    The Environmental Technologies Acceptance (ETA) Program at the Energy and Environmental Research Center (EERC) is intended to advance the development, commercial acceptance, and timely deployment of selected private sector technologies for the cleanup of sites in the nuclear defense complex as well as the greater market. As shown in Table 1, this cooperative agreement funded by the National Energy Technology Laboratory (NETL) consists of three tasks: Technology Selection, Technology Development, and Technology Verification. As currently conceived, the ETA will address the needs of as many technologies as appropriate under its current 3-year term. This report covers activities during the first 6 months of the 3-year ETA program

  1. Division of Environmental Control Technology program, 1977

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-06-01

    Environmental engineering programs are reviewed for the following technologies; coal; petroleum and gas; oil shale; solar; geothermal and energy conservation; nuclear energy; and decontamination and decommissioning. Separate abstracts were prepared for each technology. (MHR)

  2. Technologies for Self-Determination for Youth with Developmental Disabilities. Technologies for Voice: A Critical Issues Brief

    Science.gov (United States)

    Skouge, James R.; Kelly, Mary L.; Roberts, Kelly D.; Leake, David W.; Stodden, Robert A.

    2007-01-01

    This paper focuses on "technologies for voice" that are related to the self-determination of youth with developmental disabilities. The authors describe a self-determination model that values family-focused, community-referenced pedagogies employing "new media" to give voice to youth and their families. In line with the adage that a picture is…

  3. How Programming Fits with Technology Education Curriculum

    Science.gov (United States)

    Wright, Geoffrey A.; Rich, Peter; Leatham, Keith R.

    2012-01-01

    Programming is a fundamental component of modern society. Programming and its applications influence much of how people work and interact. Because of people's reliance on programming in one or many of its applications, there is a need to teach students to be programming literate. Because the purpose of the International Technology and Engineering…

  4. Inducing omnipotence or powerlessness in learners with developmental and attention difficulties through structuring technologies

    DEFF Research Database (Denmark)

    Voldborg, Hanne; Sorensen, Elsebeth Korsgaard

    2017-01-01

    at school? Using this lens, the authors examine, to what extent technology may assist teachers to create more ideal learning environments by reducing the threat for these learners and enable them to participate in learning. Virtual Learning Environments (VLEs), digital templates, timers and calendars......, become aware and understand their own role in the classroom. This paper suggests technologies for structuring and overviewing as basic assistive tools for equalizing the learning possibilities for learners with developmental and attention difficulties in an inclusive school setting....

  5. Developmental programming of energy balance regulation: is physical activity more 'programmable' than food intake?

    Science.gov (United States)

    Zhu, Shaoyu; Eclarinal, Jesse; Baker, Maria S; Li, Ge; Waterland, Robert A

    2016-02-01

    Extensive human and animal model data show that environmental influences during critical periods of prenatal and early postnatal development can cause persistent alterations in energy balance regulation. Although a potentially important factor in the worldwide obesity epidemic, the fundamental mechanisms underlying such developmental programming of energy balance are poorly understood, limiting our ability to intervene. Most studies of developmental programming of energy balance have focused on persistent alterations in the regulation of energy intake; energy expenditure has been relatively underemphasised. In particular, very few studies have evaluated developmental programming of physical activity. The aim of this review is to summarise recent evidence that early environment may have a profound impact on establishment of individual propensity for physical activity. Recently, we characterised two different mouse models of developmental programming of obesity; one models fetal growth restriction followed by catch-up growth, and the other models early postnatal overnutrition. In both studies, we observed alterations in body-weight regulation that persisted to adulthood, but no group differences in food intake. Rather, in both cases, programming of energy balance appeared to be due to persistent alterations in energy expenditure and spontaneous physical activity (SPA). These effects were stronger in female offspring. We are currently exploring the hypothesis that developmental programming of SPA occurs via induced sex-specific alterations in epigenetic regulation in the hypothalamus and other regions of the central nervous system. We will summarise the current progress towards testing this hypothesis. Early environmental influences on establishment of physical activity are likely an important factor in developmental programming of energy balance. Understanding the fundamental underlying mechanisms in appropriate animal models will help determine whether early life

  6. Clinical application and developmental trend of radiofrequency ablation technology

    International Nuclear Information System (INIS)

    Chen Dongfeng

    2009-01-01

    For recent two decades, radiofrequency ablation technology has made great progress in the field of the treatment for neoplasm. At the very beginning, radiofrequency ablation was adopted in treating the hepatic carcinoma, and since then it has been gradually practiced in treating malignancies of lung, bone, kidney, breast, prostate and other solid tumors. Statistical report of the year 2008 has indicated that in the aspect of similar therapeutic measures radiofrequency ablation therapy for tumors holds a 9% market share. Moreover, in the coming years the clinical use of this kind of therapy for tumors will be steadily increasing by 13% every year. (authors)

  7. Developmental GPR mine detection technology known as Balanced Bridge

    Science.gov (United States)

    Sherbondy, Kelly D.; Lang, David A.

    1995-06-01

    The Balanced Bridge (BB) detection concept was developed just after the end of WWII. It has been researched for many years since then but it has never truly overcome the following inherent problems: sensitivity to antenna height and tilt variations, detectability of flush mines, sensitivity to soil moisture content, high false alarms, and most importantly, the inability to detect small anti-personnel (AP) mines. Even with all of these shortcomings, the BB sensor technology is still one of the most promising electrmagnetic mine detection systems. This paper will address a new BB detector and its preliminary field performance compared to earlier BB research. The new BB detector has superior capabilities compared to earlier BB efforts involving single frequency or single octave excitation because the new BB operates over a multi-octave bandwidth. The new BB detector also incorporates audio and visual presentations of digitally processed signals where earlier versions only had an audible announcement derived from a simple thresholding algorithm. New BB designs addressing previous BB deficiencies will also be discussed. Design changes include using a broadband printed circuit board antenna, RF transmit and receive components, and a digital signal processor. This new BB detector will be tested at an Advanced Technology Demonstration (ATD) evaluation in FY95. The ATD exit criteria will be discussed and compared to recent field testing of the new BB detector. Preliminary results with the new BB system have demonstrated encouraging results which will be incorporated in this paper.

  8. Early Developmental Program Shapes Colony Morphology in Bacteria

    Directory of Open Access Journals (Sweden)

    Gideon Mamou

    2016-03-01

    Full Text Available When grown on a solid surface, bacteria form highly organized colonies, yet little is known about the earliest stages of colony establishment. Following Bacillus subtilis colony development from a single progenitor cell, a sequence of highly ordered spatiotemporal events was revealed. Colony was initiated by the formation of leading-cell chains, deriving from the colony center and extending in multiple directions, typically in a “Y-shaped” structure. By eradicating particular cells during these early stages, we could influence the shape of the resulting colony and demonstrate that Y-arm extension defines colony size. A mutant in ymdB encoding a phosphodiesterase displayed unordered developmental patterns, indicating a role in guiding these initial events. Finally, we provide evidence that intercellular nanotubes contribute to proper colony formation. In summary, we reveal a “construction plan” for building a colony and provide the initial molecular basis for this process.

  9. Innovative Technology Development Program. Final summary report

    International Nuclear Information System (INIS)

    Beller, J.

    1995-08-01

    Through the Office of Technology Development (OTD), the U.S. Department of Energy (DOE) has initiated a national applied research, development, demonstration, testing, and evaluation program, whose goal has been to resolve the major technical issues and rapidly advance technologies for environmental restoration and waste management. The Innovative Technology Development (ITD) Program was established as a part of the DOE, Research, Development, Demonstration, Testing, and Evaluation (RDDT ampersand E) Program. The plan is part of the DOE's program to restore sites impacted by weapons production and to upgrade future waste management operations. On July 10, 1990, DOE issued a Program Research and Development Announcement (PRDA) through the Idaho Operations Office to solicit private sector help in developing innovative technologies to support DOE's clean-up goals. This report presents summaries of each of the seven projects, which developed and tested the technologies proposed by the seven private contractors selected through the PRDA process

  10. CICT Computing, Information, and Communications Technology Program

    Science.gov (United States)

    Laufenberg, Lawrence; Tu, Eugene (Technical Monitor)

    2002-01-01

    The CICT Program is part of the NASA Aerospace Technology Enterprise's fundamental technology thrust to develop tools. processes, and technologies that enable new aerospace system capabilities and missions. The CICT Program's four key objectives are: Provide seamless access to NASA resources- including ground-, air-, and space-based distributed information technology resources-so that NASA scientists and engineers can more easily control missions, make new scientific discoveries, and design the next-generation space vehicles, provide high-data delivery from these assets directly to users for missions, develop goal-oriented human-centered systems, and research, develop and evaluate revolutionary technology.

  11. Clean Coal Technology Demonstration Program: Program update 1993

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The Clean Coal Technology Demonstration Program (also referred to as the CCT Program) is a $6.9 billion cost-shared industry/government technology development effort. The program is to demonstrate a new generation of advanced coal-based technologies, with the most promising technologies being moved into the domestic and international marketplace. Technology has a vital role in ensuring that coal can continue to serve U.S. energy interests and enhance opportunities for economic growth and employment while meeting the national committment to a clean and healthy global environment. These technologies are being advanced through the CCT Program. The CCT Program supports three substantive national objectives: ensuring a sustainable environment through technology; enhancing energy efficiency and reliability; providing opportunities for economic growth and employment. The technologies being demonstrated under the CCT Program reduce the emissions of sulfur oxides, nitrogen oxides, greenhouse gases, hazardous air pollutants, solid and liquid wastes, and other emissions resulting from coal use or conversion to other fuel forms. These emissions reductions are achieved with efficiencies greater than or equal to currently available technologies.

  12. Fuel Cell and Hydrogen Technologies Program | Hydrogen and Fuel Cells |

    Science.gov (United States)

    NREL Fuel Cell and Hydrogen Technologies Program Fuel Cell and Hydrogen Technologies Program Through its Fuel Cell and Hydrogen Technologies Program, NREL researches, develops, analyzes, and validates fuel cell and hydrogen production, delivery, and storage technologies for transportation

  13. Clean Technology Evaluation & Workforce Development Program

    Energy Technology Data Exchange (ETDEWEB)

    Patricia Glaza

    2012-12-01

    The overall objective of the Clean Technology Evaluation portion of the award was to design a process to speed up the identification of new clean energy technologies and match organizations to testing and early adoption partners. The project was successful in identifying new technologies targeted to utilities and utility technology integrators, in developing a process to review and rank the new technologies, and in facilitating new partnerships for technology testing and adoption. The purpose of the Workforce Development portion of the award was to create an education outreach program for middle & high-school students focused on clean technology science and engineering. While originally targeting San Diego, California and Cambridge, Massachusetts, the scope of the program was expanded to include a major clean technology speaking series and expo as part of the USA Science & Engineering Festival on the National Mall in Washington, D.C.

  14. Characterization, Monitoring and Sensor Technology Integrated Program

    International Nuclear Information System (INIS)

    1993-01-01

    This booklet contains summary sheets that describe FY 1993 characterization, monitoring, and sensor technology (CMST) development projects. Currently, 32 projects are funded, 22 through the OTD Characterization, Monitoring, and Sensor Technology Integrated Program (CMST-IP), 8 through the OTD Program Research and Development Announcement (PRDA) activity managed by the Morgantown Energy Technology Center (METC), and 2 through Interagency Agreements (IAGs). This booklet is not inclusive of those CMST projects which are funded through Integrated Demonstrations (IDs) and other Integrated Programs (IPs). The projects are in six areas: Expedited Site Characterization; Contaminants in Soils and Groundwater; Geophysical and Hydrogeological Measurements; Mixed Wastes in Drums, Burial Grounds, and USTs; Remediation, D ampersand D, and Waste Process Monitoring; and Performance Specifications and Program Support. A task description, technology needs, accomplishments and technology transfer information is given for each project

  15. Semiconductor technology program. Progress briefs

    Science.gov (United States)

    Bullis, W. M.

    1980-01-01

    Measurement technology for semiconductor materials, process control, and devices is reviewed. Activities include: optical linewidth and thermal resistance measurements; device modeling; dopant density profiles; resonance ionization spectroscopy; and deep level measurements. Standardized oxide charge terminology is also described.

  16. Technology transfer program of Microlabsat

    Science.gov (United States)

    Nakamura, Y.; Hashimoto, H.

    2004-11-01

    A 50kg-class small satellite developed by JAXA called "MicroLabSat" was launched piggyback by H-IIA rocket No. 4 on 14 December 2002. This satellite will demonstrate small satellite bus technology and conduct experiments on a new separator feasibility and remote inspection technology. All missions were completed successfully on 25 May 2003. Furthermore, the hand-construction by young JAXA engineers motivated these engineers to higher performance in learning design, assembly and testing technology. Small and medium-sized Japanese companies have recently joined together and initiated a project to develop a small satellite. The goal of the project is to commercialise small satellites, which will require low- cost development. Therefore, they have started with a satellite incorporating the components and bus technologies of MicroLabSat and have been technically supported by universities and JAXA since 2004. This satellite project, in which industry, universities and a space agency are collaborating, seeks to meet the technical challenge of launching a low-cost satellite. This paper reports JAX's strategies for developing a small satellite for demonstrating space technology as well as the development and operation results of MicroLabSat. It also describes the project status of an industry-based satellite, developed through collaboration among industries, universities and the space agency, and how the technologies of MicroLabSat are applied.

  17. Programming and Technology for Accessibility in Geoscience

    Science.gov (United States)

    Sevre, E.; Lee, S.

    2013-12-01

    Many people, students and professors alike, shy away from learning to program because it is often believed to be something scary or unattainable. However, integration of programming into geoscience education can be a valuable tool for increasing the accessibility of content for all who are interested. It is my goal to dispel these myths and convince people that: 1) Students with disabilities can use programming to increase their role in the classroom, 2) Everyone can learn to write programs to simplify daily tasks, 3) With a deep understanding of the task, anyone can write a program to do a complex task, 4) Technology can be combined with programming to create an inclusive environment for all students of geoscience, and 5) More advanced knowledge of programming and technology can lead geoscientists to create software to serve as assistive technology in the classroom. It is my goal to share my experiences using technology to enhance the classroom experience as a way of addressing the aforementioned issues. Through my experience, I have found that programming skills can be included and learned by all to enhance the content of courses without detracting from curriculum. I hope that, through this knowledge, geoscience courses can become more accessible for people with disabilities by including programming and technology to the benefit of all involved.

  18. Clean Coal Technology Demonstration Program. Program update 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    The Clean Coal Technology Demonstration Program (CCT Program) is a $7.14 billion cost-shared industry/government technology development effort. The program is to demonstrate a new generation of advanced coal-based technologies, with the most promising technologies being moved into the domestic and international marketplace. Clean coal technologies being demonstrated under the CCT program are creating the technology base that allows the nation to meet its energy and environmental goals efficiently and reliably. The fact that most of the demonstrations are being conducted at commercial scale, in actual user environments, and under conditions typical of commercial operations allows the potential of the technologies to be evaluated in their intended commercial applications. The technologies are categorized into four market sectors: advanced electric power generation systems; environmental control devices; coal processing equipment for clean fuels; and industrial technologies. Sections of this report describe the following: Role of the Program; Program implementation; Funding and costs; The road to commercial realization; Results from completed projects; Results and accomplishments from ongoing projects; and Project fact sheets. Projects include fluidized-bed combustion, integrated gasification combined-cycle power plants, advanced combustion and heat engines, nitrogen oxide control technologies, sulfur dioxide control technologies, combined SO{sub 2} and NO{sub x} technologies, coal preparation techniques, mild gasification, and indirect liquefaction. Industrial applications include injection systems for blast furnaces, coke oven gas cleaning systems, power generation from coal/ore reduction, a cyclone combustor with S, N, and ash control, cement kiln flue gas scrubber, and pulse combustion for steam coal gasification.

  19. Evidence for developmental programming of cerebral laterality in humans.

    Directory of Open Access Journals (Sweden)

    Alexander Jones

    2011-02-01

    Full Text Available Adverse fetal environments are associated with depression, reduced cognitive ability and increased stress responsiveness in later life, but underlying mechanisms are unknown. Environmental pressures on the fetus, resulting from variations in placental function and maternal nutrition, health and stress might alter neurodevelopment, promoting the development of some brain regions over others. As asymmetry of cerebral activity, with greater right hemisphere activity, has been associated with psychopathology, we hypothesized that regional specialization during fetal life might be reflected persistently in the relative activity of the cerebral hemispheres. We tested this hypothesis in 140 healthy 8-9 year-old children, using tympanic membrane temperature to assess relative blood flow to the cerebral hemispheres at rest and following psychosocial stress (Trier Social Stress Test for Children. Their birth weight and placental weight had already been measured when their mothers took part in a previous study of pregnancy outcomes. We found that children who had a smaller weight at birth had evidence of greater blood flow to the right hemisphere than to the left hemisphere (r = -.09, P = .29 at rest; r = -.18, P = .04 following stress. This finding was strengthened if the children had a relatively low birth weight for their placental weight (r = -.17, P = .05 at rest; r = -.31, P = .0005 following stress. Our findings suggest that lateralization of cerebral activity is influenced persistently by early developmental experiences, with possible consequences for long-term neurocognitive function.

  20. A Psychiatric Primer for Programs Serving People with Developmental Disabilities. Monograph #101.

    Science.gov (United States)

    Dal Pozzo, Earlene; Bernstein, Gail S.

    Intended for personnel in programs serving persons with developmental disabilities, the booklet provides basic information about the major psychiatric disorders and their treatment. Five sections cover: the major disorders; medications--uses and problems; assessment; cooordination of services; and psychiatric emergencies. Major disorders such as…

  1. The Effect of Early Childhood Developmental Program Attendance on Future School Enrollment in Rural North India

    Science.gov (United States)

    Hazarika, Gautam; Viren, Vejoya

    2013-01-01

    This paper examines the effect of prior participation in early childhood developmental programs, considered endogenous, upon 7-18 years olds' school enrollment in rural North India. Analyses by age group of data from the World Bank's 1997-98 Survey of Living Conditions in Uttar Pradesh and Bihar reveal that 7-10 year olds, 11-14 year olds, and…

  2. Federal Program Encourages Health Service Innovations on Developmental Disabilities

    Science.gov (United States)

    Nix, Mary P.

    2009-01-01

    There is always room for improvement in the delivery of health services. This article discusses the U.S. Agency for Healthcare Research and Quality's (AHRQ) Health Care Innovations Exchange (www.innovations.ahrq.gov), a comprehensive program that aims to increase awareness of innovative strategies to meet health service delivery challenges and…

  3. A Developmental Mapping Program Integrating Geography and Mathematics.

    Science.gov (United States)

    Muir, Sharon Pray; Cheek, Helen Neely

    Presented and discussed is a model which can be used by educators who want to develop an interdisciplinary map skills program in geography and mathematics. The model assumes that most children in elementary schools perform cognitively at Piaget's concrete operational stage, that readiness for map skills can be assessed with Piagetian or…

  4. Geothermal Technologies Program 2011 Peer Review Report

    Energy Technology Data Exchange (ETDEWEB)

    Hollett, Douglas [Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States); Stillman, Greg [Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-06-01

    On June 6-10, 2011, the U.S. Department of Energy (DOE), Office of Energy Efficiency and Renewable Energy (EERE), Geothermal Technologies Program (GTP or the Program) conducted its annual program peer review in Bethesda, Maryland. In accordance with the EERE Peer Review Guide, the review provides an independent, expert evaluation of the strategic goals and direction of the program and is a forum for feedback and recommendations on future program planning. The purpose of the review was to evaluate DOE-funded projects for their contribution to the mission and goals of the Program and to assess progress made against stated objectives.

  5. Maternal dietary free or bound fructose diversely influence developmental programming of lipogenesis

    OpenAIRE

    Yuruk, Armagan Aytug; Nergiz-Unal, Reyhan

    2017-01-01

    Background Maternal dietary choices throughout preconception, pregnancy, and lactation irreversibly affect the development of fetal tissues and organs, known as fetal programming. Recommendations tend to emphasize reducing added sugars. However, the impact of maternal dietary free or bound fructose in added sugars on developmental programming of lipogenesis is unknown. Methods Virgin Sprague-Dawley rats were randomly divided into five groups. Rats were given feed and plain water (control) or ...

  6. Program for Critical Technologies in Breast Oncology

    National Research Council Canada - National Science Library

    Costa, Jose

    1997-01-01

    In Year 3 of The Program for Critical Technologies in Breast Oncology (PCTBO), we have expanded services that were initiated in July 1994 to establish a core technical and tissue procurement resource that: (1...

  7. Developmental outcomes of Japanese children born through Assisted Reproductive Technology (ART) in toddlerhood.

    Science.gov (United States)

    Aoki, Sayaka; Hashimoto, Keiji; Ogawa, Kohei; Horikawa, Reiko; Sago, Haruhiko

    2018-05-01

    This study aimed to investigate developmental outcomes of Japanese babies born through Assisted Reproductive Technology (ART) at ages 2 and 3. The data were gathered from 1085 children in a hospital-based cohort study conducted in Japan. The children's level of development was assessed through a parent-rated questionnaire, the Kinder Infant Development Scale, which consists of nine developmental domains. We compared the development of children born through ART and those born naturally by conducting analyses of covariance. For the analyses, the effect of maternal age, family income, parental education and multiple birth were controlled for. At 24 months, no significant difference was found between children born through ART and those born naturally in development in any domain. At 36 months, a significant difference was found in development of Receptive language (F (1, 845) = 6.148, P = 0.013), Expressive language (F (1, 845) = 4.060, P = 0.044) and Language concept (F (1, 845) = 6.968, P = 0.008). For these domains, children born through ART had a significantly higher developmental age compared to children born naturally. At age 2, no significant difference was found between the children born through ART and those born naturally in nine developmental domains, although at age 3, the children born through ART showed significantly better language development than the children born naturally. © 2018 Japan Society of Obstetrics and Gynecology.

  8. Mine Waste Technology Program Electrochemical Tailings Cover

    Science.gov (United States)

    This report summarizes the results of Mine Waste Technology Program (MWTP) Activity III, Project 40, Electrochemical Tailings Cover, funded by the U.S. Environmental Protection Agency (EPA) and jointly administered by EPA and the U.S. Department of Energy (DOE). MSE Technology A...

  9. Solar Energy Technologies Program Newsletter - July 2009

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-07-01

    This quarterly newsletter is intended for participants and stakeholders in the DOE Solar Program. The content includes features on technology development, market transformation, and policy analysis for solar. Highlights include solar industry updates, DOE funding opportunity announcements and awards, and national laboratory technology developments.

  10. Characterization monitoring & sensor technology crosscutting program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The purpose of the Characterization, Monitoring, and Sensor Technology Crosscutting Program (CMST-CP) is to deliver appropriate characterization, monitoring, and sensor technology (CMST) to the OFfice of Waste Management (EM-30), the Office of Environmental Restoration (EM-40), and the Office of Facility Transition and Management (EM-60).

  11. The Changing Nature of Educational Technology Programs

    Science.gov (United States)

    Spector, J. Michael

    2015-01-01

    The many changes in educational technologies have been well documented in both the professional and popular literature. What is less well documented is the changing nature of programs that prepare individuals for careers in the broad multi-disciplinary field of educational technology. This article is a first attempt to look at how educational…

  12. EPRI nuclear power plant decommissioning technology program

    International Nuclear Information System (INIS)

    Kim, Karen S.; Bushart, Sean P.; Naughton, Michael; McGrath, Richard

    2011-01-01

    The Electric Power Research Institute (EPRI) is a non-profit research organization that supports the energy industry. The Nuclear Power Plant Decommissioning Technology Program conducts research and develops technology for the safe and efficient decommissioning of nuclear power plants. (author)

  13. Developmental programming in response to maternal over-nutrition

    Directory of Open Access Journals (Sweden)

    Maria eAlfaradhi

    2011-06-01

    Full Text Available Metabolic disorders have seen an increased prevalence in recent years in developed as well as developing countries. While it is clear lifestyle choices and habits have contributed to this epidemic, mounting evidence suggests the nutritional milieu during critical stages of development in early life can ‘program’ individuals to develop the metabolic syndrome later in life. Extensive epidemiological data presents an association between maternal obesity and nutrition during pregnancy and offspring obesity, and a number of animal models have been established in order to uncover the underlying mechanisms contributing to the programming of physiological systems. It is hard to distinguish the causal factors due to the complex nature of the maternal-fetal relationship; however, in order to develop adequate prevention strategies it is vital to identify which maternal factor(s – be it the diet, diet-induced obesity or weight gain – and at which time during early development instigate the programmed phenotype. Curtailing the onset of obesity at this early stage in life presents a promising avenue through which to stem the growing epidemic of obesity.

  14. Strategies for reversing the effects of metabolic disorders induced as a consequence of developmental programming

    Directory of Open Access Journals (Sweden)

    Mark H Vickers

    2012-07-01

    Full Text Available Obesity and the metabolic syndrome have reached epidemic proportions worldwide with far-reaching health care and economic implications. The rapid increase in the prevalence of these disorders suggests that environmental and behavioural influences, rather than genetic causes, are fuelling the epidemic. The developmental origins of health and disease hypothesis has highlighted the link between the periconceptual, fetal and early infant phases of life and the subsequent development of metabolic disorders in later life. In particular, the impact of poor maternal nutrition on susceptibility to later life metabolic disease in offspring is now well documented. Several studies have now shown, at least in experimental animal models, that some components of the metabolic syndrome, induced as a consequence of developmental programming, are potentially reversible by nutritional or targeted therapeutic interventions during windows of developmental plasticity. This review will focus on critical windows of development and possible therapeutic avenues that may reduce metabolic and obesogenic risk following an adverse early life environment.

  15. Dietary regulation of developmental programming in ruminants: epigenetic modifications in the germline.

    Science.gov (United States)

    Sinclair, K D; Karamitri, A; Gardner, D S

    2010-01-01

    Ruminants have been utilised extensively to investigate the developmental origins of health and disease, with the sheep serving as the model species of choice to complement dietary studies in the rat and mouse. Surprisingly few studies, however, have investigated delayed effects of maternal undernutrition during pregnancy on adult offspring health and a consistent phenotype, together with underlying mechanistic pathways, has not emerged. Nevertheless, when broad consideration is given to all studies with ruminants it is apparent that interventions that are initiated very early in gestation, and/or prior to conception, lead to greater effects on adult physiology than those that are specifically targeted to late gestation. Effects induced following dietary interventions at the earliest stages of mammalian development have been shown to arise as a consequence of alterations to key epigenetic processes that occur in germ cells and pluripotent embryonic cells. Currently, our understanding of epigenetic programming in the germline is greatest for the mouse, and is considered in detail in this article together with what is known in ruminants. This species imbalance, however, looks set to change as fully annotated genomic maps are developed for domesticated large animal species, and with the advent of 'next-generation' DNA sequencing technologies that have the power to globally map the epigenome at single-base-pair resolution. These developments would help to address such issues as sexually dimorphic epigenetic alterations to DNA methylation that have been found to arise following dietary restrictions during the peri-conceptional period, the effects of paternal nutritional status on epigenetic programming through the germline, and transgenerational studies where, in future, greater emphasis in domesticated ruminants should be placed on traits of agricultural importance.

  16. Telecommunications and Technology Infrastructure Program, 2013

    Science.gov (United States)

    California Community Colleges, Chancellor's Office, 2014

    2014-01-01

    This 16th annual report highlights up-to-date information on the programs supported through the Chancellor's Office Telecommunications and Technology Infrastructure Program (TTIP). To summarize 2012-13, one would describe it as a year of planning and preparation. The system-wide budget cuts of the past few years, reports of impacted classes, staff…

  17. Summary report on focusing HTGR technology programs

    International Nuclear Information System (INIS)

    The program effort to focus technology development activities consists of work in three areas: the identification of Reference Plant Options; the identification of design data needs and supporting program requirements for these plants; and the development of management plans and tools consistent with the execution of candidate systems

  18. Small Spacecraft Technology Initiative Education Program

    Science.gov (United States)

    1995-01-01

    A NASA engineer with the Commercial Remote Sensing Program (CRSP) at Stennis Space Center works with students from W.P. Daniels High School in New Albany, Miss., through NASA's Small Spacecraft Technology Initiative Program. CRSP is teaching students to use remote sensing to locate a potential site for a water reservoir to offset a predicted water shortage in the community's future.

  19. New energy technologies. Research program proposition

    International Nuclear Information System (INIS)

    2005-02-01

    This document presents the most promising program propositions of research and development and the public financing needed for their realization. The concerned technologies are: the hydrogen and the fuel cell PAN-H, the separation and the storage of the CO 2 , the photovoltaic solar electricity, the PREBAT program of the building energy recovery and the bio-energies. (A.L.B.)

  20. Differentiated Technology-based Interventions for Enhancing Understanding, Flow and Self-efficacy by Learners with Developmental and Attention Deficits

    DEFF Research Database (Denmark)

    Voldborg, Hanne; Sorensen, Elsebeth Korsgaard

    2016-01-01

    This paper investigates the potential of digital technologies for strengthening the participation and inclusion of learners with developmental and attention Deficits (focus learners) into the mainstream classroom. The paper describes the authors’ approach to the challenge of researching the extent...

  1. Epigenetic developmental programs and adipogenesis: implications for psychotropic induced obesity.

    Science.gov (United States)

    Chase, Kayla; Sharma, Rajiv P

    2013-11-01

    Psychotropic agents are notorious for their ability to increase fat mass in psychiatric patients. The two determinants of fat mass are the production of newly differentiated adipocytes (adipogenesis), and the volume of lipid accumulation. Epigenetic programs have a prominent role in cell fate commitments and differentiation required for adipogenesis. In parallel, epigenetic effects on energy metabolism are well supported by several genetic models. Consequently, a variety of psychotropics, often prescribed in combinations and for long periods, may utilize a common epigenetic effector path causing an increase in adipogenesis or reduction in energy metabolism. In particular, the recent discovery that G protein coupled signaling cascades can directly modify epigenetic regulatory enzymes implicates surface receptor activity by psychotropic medications. The potential therapeutic implications are also suggested by the effects of the clinically approved antidepressant tranylcypromine, also a histone demethylase inhibitor, which has impressive therapeutic effects on metabolism in the obese phenotype.

  2. Spinoff 2002: Fortieth Anniversary Technology Utilization Program

    Science.gov (United States)

    2002-01-01

    Since its inception 40 years ago, NASA's Technology Transfer Program has led the way for our nation to benefit from cutting-edge aerospace technologies. In addition to contributing to U.S. economic growth, these technologies are improving the quality of life on Earth while finding new ways to protect and preserve it. NASA's research and development efforts have advanced areas in medicine, communications, manufacturing, computer technology, and homeland security. These breakthroughs, translated into commercial products, are enhancing the lives of Americans everywhere. When a congressional mandate led NASA to develop the Scientific and Technical Information (STI) Program, the Agency began a wide dissemination of its research and development results. In doing so, NASA recognized that many of its technologies were transferable to industry for the development of commercial products. As a result, the Technology Utilization Program was born in 1962. The successful program went through several changes over the years, as its philosophy, mission, and goals adapted into the Technology Transfer Program we know today. The program strives to make the latest technologies available to industry as soon as they are developed. Each year, NASA's Spinoff publication showcases new products and services resulting from commercial partnerships between NASA and private industry. In the 2002 issue, the NASA field centers reflect upon the growth that has made these innovations available to the public. The Research and Development section examines past achievements, current successes, and future goals for each of the ten NASA centers. The Commercial Benefits section proudly highlights 51 new spinoff products, including a heart pump for patients needing a heart transplant, as well as an air purifier that destroys anthrax spores. The Technology Transfer and Outreach section describes the outreach achievements and educational successes made possible through the NASA Commercial Technology Network

  3. Ultrashort pulsed laser technology development program

    Science.gov (United States)

    Manke, Gerald C.

    2014-10-01

    The Department of Navy has been pursuing a technology development program for advanced, all-fiber, Ultra Short Pulsed Laser (USPL) systems via Small Business Innovative Research (SBIR) programs. Multiple topics have been published to promote and fund research that encompasses every critical component of a standard USPL system and enable the demonstration of mJ/pulse class systems with an all fiber architecture. This presentation will summarize published topics and funded programs.

  4. Advancing CANDU technology AECL's Development program

    International Nuclear Information System (INIS)

    Torgerson, D.F.

    1997-01-01

    AECL has a comprehensive product development program that is advancing all aspects of CANDU technology including fuel and fuel cycles, fuel channels, heavy water and tritium technology, safety technology, components and systems, constructability, health and environment, and control and instrumentation. The technology arising from these programs is being incorporated into the CANDU design through an evolutionary process. This evolutionary process is focused on improving economics, enhancing safety and ensuring fuel cycle flexibility to secure fuel supply for the foreseeable future. This strategic thrusts are being used by CANDU designers and researchers to set priorities and goals for AECL's development activities. The goals are part of a 25-year development program that culminates in the 'CANDU X'. The 'CANDU X' is not a specific design - it is a concept that articulates our best extrapolation of what is achievable with the CANDU design over the next 25 years, and includes the advanced features arising from the R and D and engineering to be done over that time. AECL's current product, the 700 MWe class CANDU 6 and the 900 MWe class CANDU 9, both incorporate output from the development programs as the technology become available. A brief description of each development areas is given below. The paper ends with the conclusion that AECL has a clear vision of how CANDU technology and products will evolve over the next several years, and has structured a comprehensive development program to take full advantage of the inherent characteristics of heavy water reactors. (author)

  5. Immobilization needs and technology programs

    International Nuclear Information System (INIS)

    Gray, L.W.; Kan, T.; Shaw, H.; Armantrout, G.

    1995-01-01

    In the aftermath of the Cold War, the US and Russia agreed to large reductions in nuclear weapons. To aid in the selection of long-term management options, DOE has undertaken a multifaceted study to select options for storage and disposition of plutonium in keeping with US policy that plutonium must be subjected to the highest standards of safety, security, and accountability. One alternative being considered is immobilization. To arrive at a suitable immobilization form, we first reviewed published information on high-level waste immobilization technologies and identified 72 possible plutonium immobilization forms to be prescreened. Surviving forms were further screened using multi-attribute utility analysis to determine the most promising technology families. Promising immobilization families were further evaluated to identify chemical, engineering, environmental, safety, and health problems that remain to be solved prior to making technical decisions as to the viability of using the form for long- term disposition of plutonium. From this evaluation, a detailed research and development plan has been developed to provide answers to these remaining questions

  6. Heavy-Section Steel Technology Program

    International Nuclear Information System (INIS)

    Pennell, W.E.

    1992-11-01

    The Heavy-Section Steel Technology (HSST) Program is conducted for the Nuclear Regulatory Commission (NRC) by Oak Ridge National Laboratory (ORNL). The program focus is on the development and validation of technology for the assessment of fracture-prevention margins in commercial nuclear reactor pressure vessels. The HSST Program is organized in 11 tasks: program management, fracture methodology and analysis, material characterization and properties, special technical assistance, fracture analysis computer programs, cleavage-crack initiation, cladding evaluations, pressurized-thermal-shock technology, analysis methods validation, fracture evaluation tests, and warm prestressing. The program tasks have been structured to place emphasis on the resolution fracture issues with near-term licensing significance. Resources to execute the research tasks are drawn from ORNL with subcontract support from universities and other research laboratories. Close contact is maintained with the sister Heavy-Section Steel Irradiation (HSSI) Program at ORNL and with related research programs both in the United States and abroad. This report provides an overview of principal developments in each of the II program tasks from October 1, 1991 to March 31, 1992

  7. Next Generation Launch Technology Program Lessons Learned

    Science.gov (United States)

    Cook, Stephen; Tyson, Richard

    2005-01-01

    In November 2002, NASA revised its Integrated Space Transportation Plan (ISTP) to evolve the Space Launch Initiative (SLI) to serve as a theme for two emerging programs. The first of these, the Orbital Space Plane (OSP), was intended to provide crew-escape and crew-transfer functions for the ISS. The second, the NGLT Program, developed technologies needed for safe, routine space access for scientific exploration, commerce, and national defense. The NGLT Program was comprised of 12 projects, ranging from fundamental high-temperature materials research to full-scale engine system developments (turbine and rocket) to scramjet flight test. The Program included technology advancement activities with a broad range of objectives, ultimate applications/timeframes, and technology maturity levels. An over-arching Systems Engineering and Analysis (SE&A) approach was employed to focus technology advancements according to a common set of requirements. Investments were categorized into three segments of technology maturation: propulsion technologies, launch systems technologies, and SE&A.

  8. Care of preterm infants: programs of research and their relationship to developmental science.

    Science.gov (United States)

    Holditch-Davis, Diane; Black, Beth Perry

    2003-01-01

    The purpose of this review was to examine the topics covered in current programs of nursing research on the care of the preterm infant and to determine the extent to which this research is informed by developmental science. A researcher was considered to have a current program of research if he or she had at least five publications published since 1990 and was the first author on at least three of them. The infants in a study could be any age from birth throughout childhood; studies focusing on parenting, nursing, or other populations of infants were not included. Seventeen nurse researchers had current programs of research in this area. These programs had four themes. Those of Becker, Evans, Pridham, Shiao, and Zahr focused on infant responses to the neonatal intensive care unit (NICU) environment and treatments. Franck, Johnston, and Stevens focused on pain management. Harrison, Ludington-Hoe, and White-Traut's research focused on infant stimulation. Holditch-Davis, McCain, McGrath, Medoff-Cooper, Schraeder, and Youngblut studied infant behavior and development. These research programs had many strengths, including strong interdisciplinary focus and clinical relevance. However, additional emphasis is needed on the care of the critically ill infant. Also, despite the fact that the preterm infant's neurological system develops rapidly over the first year, only three of these researchers used a developmental science perspective. Only research on infant behavior and development focused on the developmental changes that the infants were experiencing. Most of the studies were longitudinal, but many did not use statistics appropriate for identifying stability and change over time. The response of individual infants and the broader ecological context as evidenced by factors such as gender, ethnic group, culture, and intergenerational effects were rarely examined. Thus research on the care of preterm infants could be expanded if the developmental science perspective

  9. Technology Innovations from NASA's Next Generation Launch Technology Program

    Science.gov (United States)

    Cook, Stephen A.; Morris, Charles E. K., Jr.; Tyson, Richard W.

    2004-01-01

    NASA's Next Generation Launch Technology Program has been on the cutting edge of technology, improving the safety, affordability, and reliability of future space-launch-transportation systems. The array of projects focused on propulsion, airframe, and other vehicle systems. Achievements range from building miniature fuel/oxygen sensors to hot-firings of major rocket-engine systems as well as extreme thermo-mechanical testing of large-scale structures. Results to date have significantly advanced technology readiness for future space-launch systems using either airbreathing or rocket propulsion.

  10. Effects of a parent-implemented Developmental Reciprocity Treatment Program for children with autism spectrum disorder.

    Science.gov (United States)

    Gengoux, Grace W; Schapp, Salena; Burton, Sarah; Ardel, Christina M; Libove, Robin A; Baldi, Gina; Berquist, Kari L; Phillips, Jennifer M; Hardan, Antonio Y

    2018-05-01

    Developmental approaches to autism treatment aim to establish strong interpersonal relationships through joint play. These approaches have emerging empirical support; however, there is a need for further research documenting the procedures and demonstrating their effectiveness. This pilot study evaluated changes in parent behavior and child autism symptoms following a 12-week Developmental Reciprocity Treatment parent-training program. A total of 22 children with autism spectrum disorder between 2 and 6 years (mean age = 44.6 months, standard deviation = 12.7) and a primary caregiver participated in 12 weekly sessions of Developmental Reciprocity Treatment parent training, covering topics including introduction to developmental approaches, supporting attention and motivation, sensory regulation and sensory-social routines, imitation/building nonverbal communication, functional language development, and turn taking. Results indicated improvement in aspects of parent empowerment and social quality of life. Improvement in core autism symptoms was observed on the Social Responsiveness Scale total score (F(1,19): 5.550, p = 0.029), MacArthur-Bates Communicative Development Inventories number of words produced out of 680 (F(1,18): 18.104, p = 0.000), and two subscales of the Repetitive Behavior Scale, Revised (compulsive, p = 0.046 and restricted, p = 0.025). No differences in sensory sensitivity were observed on the Short Sensory Profile. Findings from this pilot study indicate that Developmental Reciprocity Treatment shows promise and suggest the need for future controlled trials of this developmentally based intervention.

  11. The NASA automation and robotics technology program

    Science.gov (United States)

    Holcomb, Lee B.; Montemerlo, Melvin D.

    1986-01-01

    The development and objectives of the NASA automation and robotics technology program are reviewed. The objectives of the program are to utilize AI and robotics to increase the probability of mission success; decrease the cost of ground control; and increase the capability and flexibility of space operations. There is a need for real-time computational capability; an effective man-machine interface; and techniques to validate automated systems. Current programs in the areas of sensing and perception, task planning and reasoning, control execution, operator interface, and system architecture and integration are described. Programs aimed at demonstrating the capabilities of telerobotics and system autonomy are discussed.

  12. A Mobile Early Stimulation Program to Support Children with Developmental Delays in Brazil.

    Science.gov (United States)

    Dias, Raquel da Luz; Silva, Kátia Cristina Correa Guimarães; Lima, Marcela Raquel de Oliveira; Alves, João Guilherme Bezerra; Abidi, Syed Sibte Raza

    2018-01-01

    Developmental delay is a deviation development from the normative milestones during the childhood and it may be caused by neurological disorders. Early stimulation is a standardized and simple technique to treat developmental delays in children (aged 0-3 years), allowing them to reach the best development possible and to mitigate neuropsychomotor sequelae. However, the outcomes of the treatment depending on the involvement of the family, to continue the activities at home on a daily basis. To empower and educate parents of children with neurodevelopmental delays to administer standardized early stimulation programs at home, we developed a mobile early stimulation program that provides timely and evidence-based clinical decision support to health professionals and a personalized guidance to parents about how to administer early stimulation to their child at home.

  13. Characterization, monitoring, and sensor technology crosscutting program: Technology summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The purpose of the Characterization, Monitoring, and Sensor Technology Crosscutting Program (CMST-CP) is to deliver appropriate characterization, monitoring, and sensor technology (CMST) to the Office of Waste Management (EM-30), the Office of Environmental Restoration (EM-40), and the Office of Facility Transition and Management (EM-60). The technology development must also be cost effective and appropriate to EM-30/40/60 needs. Furthermore, the required technologies must be delivered and implemented when needed. Accordingly, and to ensure that available DOE and other national resources are focused an the most pressing needs, management of the technology development is concentrated on the following Focus Areas: Contaminant Plume Containment and Remediation (PFA); Landfill Stabilization (LSFA); High-Level Waste Tank Remediation (TFA); Mixed Waste Characterization, Treatment, and Disposal (MWFA); and Facility Deactivation, Decommissioning, and Material Disposition (FDDMDFA). Brief descriptions of CMST-CP projects funded in FY95 are presented.

  14. Characterization, monitoring, and sensor technology crosscutting program: Technology summary

    International Nuclear Information System (INIS)

    1995-06-01

    The purpose of the Characterization, Monitoring, and Sensor Technology Crosscutting Program (CMST-CP) is to deliver appropriate characterization, monitoring, and sensor technology (CMST) to the Office of Waste Management (EM-30), the Office of Environmental Restoration (EM-40), and the Office of Facility Transition and Management (EM-60). The technology development must also be cost effective and appropriate to EM-30/40/60 needs. Furthermore, the required technologies must be delivered and implemented when needed. Accordingly, and to ensure that available DOE and other national resources are focused an the most pressing needs, management of the technology development is concentrated on the following Focus Areas: Contaminant Plume Containment and Remediation (PFA); Landfill Stabilization (LSFA); High-Level Waste Tank Remediation (TFA); Mixed Waste Characterization, Treatment, and Disposal (MWFA); and Facility Deactivation, Decommissioning, and Material Disposition (FDDMDFA). Brief descriptions of CMST-CP projects funded in FY95 are presented

  15. Reactor Containment Spray Technology Program

    Energy Technology Data Exchange (ETDEWEB)

    Row, T. H. [Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    1968-12-15

    The design basis accident in water moderated power reactors is a loss-of-coolant accident in which water sprays are generally employed to control the containment pressure transient by condensing the released steam-air mixture. Additives to the spray have been proposed as a way to increase their usefulness by enhancing the removal of various forms of radioiodine from the containment atmosphere. A program to investigate the gas-liquid systems involved is co-ordinated by ORNL for the US Atomic Energy Commission. A basic part of the program is the search for various chemical additives that will increase the spray affinity for molecular iodine and methyl iodide. A method for evaluating additives was developed that measures equilibrium distribution coefficients for iodine between air and aqueous solutions. Additives selected are used in single drop-wind tunnel experiments where the circulating gas contains iodine or CH{sub 3}I. Mass transfer coefficients and transient distribution coefficients have been determined as a function of relative humidity, temperature, drop size, and solution pH and concentration. Tests have shown that surfactants and organic amines increase the solution ability to getter CH{sub 3}l. Results from single drop tests help in planning spray experiments in the Nuclear Safety Pilot Plant, a large ({approx}38 m{sup 3}) facility, where accident conditions are closely simulated. Iodine and CH{sub 3}I removal rates have been determined for a number of solutions, including 1 wt% Na{sub 2}S{sub 2}O{sub 3} + 3000 ppm B + 0.153 M NaOH and 3000 ppm B + 0.153 M NaOH. The additive has very little effect in removal of I{sub 2} with half-lives of less than 1 mm typical for any aqueous solution. These same solutions remove CH{sub 3}I with a half-life of one hour. Analytical models for the removal processes have been developed. Consideration is also being given to corrosion, thermal and radiation stability of the solutions. Radiation studies have indicated the loss

  16. Heavy-Section Steel Technology program overview

    International Nuclear Information System (INIS)

    Pennell, W.E.

    1990-01-01

    This paper presents a status review of ongoing HSST program tasks aimed at refining the technology used in analysis of reactor pressure vessel fracture margins under pressurized thermal-shock (PTS) loading. Specific fracture-technology issues addressed include vessel flaw density and distribution, shallow flaws, fracture-toughness data transfer, circumferential cracks, ductile tearing and the influence of low-tearing toughness in stainless steel cladding. Preliminary results from the analysis and test programs are presented, together with interim assessments of their potential impact on a reactor vessel PTS analysis. 31 refs., 23 figs., 1 tab

  17. Clean coal technology demonstration program: Program update 1996-97

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The Clean Coal Technology Demonstration Program (known as the CCT Program) reached a significant milestone in 1996 with the completion of 20 of the 39 active projects. The CCT Program is responding to a need to demonstrate and deploy a portfolio of technologies that will assure the U.S. recoverable coal reserves of 297 billion tons could continue to supply the nation`s energy needs economically and in a manner that meets the nation`s environmental objectives. This portfolio of technologies includes environmental control devices that contributed to meeting the accords on transboundary air pollution recommended by the Special Envoys on Acid Rain in 1986. Operational, technical, environmental, and economic performance information and data are now flowing from highly efficient, low-emission, advanced power generation technologies that will enable coal to retain its prominent role into the next millennium. Further, advanced technologies are emerging that will enhance the competitive use of coal in the industrial sector, such as in steelmaking. Coal processing technologies will enable the entire coal resource base to be used while complying with environmental requirements. These technologies are producing products used by utilities and industrial processes. The capability to coproduce products, such as liquid and solid fuels, electricity, and chemicals, is being demonstrated at a commercial scale by projects in the CCT Program. In summary, this portfolio of technologies is satisfying the national need to maintain a multifuel energy mix in which coal is a key component because of its low-cost, availability, and abundant supply within the nation`s borders.

  18. Divison of Environmental Control Technology program, 1978

    International Nuclear Information System (INIS)

    1979-06-01

    This report covers Division of Environmental Control Technology projects in progress during FY 1978, within the Office of the Assistant Secretary for Environment, Department of Energy. It is the second in a planned series of annual reports. The Division of Environmental Control Technology (ECT) continues to support the Assistant Secretary for Environment (EV) in discharging two primary responsibilities: (1) under the Environmental Engineering (EE) Program, the independent overview and assessment of environmental control aspects of both the U.S. Department of Energy's (DOE) research, development, and demonstration (RD and D) programs and the Nation's energy policies, and (2) under the Decontamination and Decommissioning Program, the reduction of potential environmental hazards at the radioactively contaminated sites that are presently owned or were formerly used by the Government. This report presents a short summary of objectives, approach, progress and results, future plans, and a reference bibliography for each research, development, or assessment project within the program areas described above

  19. NASA Technology Demonstrations Missions Program Overview

    Science.gov (United States)

    Turner, Susan

    2011-01-01

    The National Aeronautics and Space Administration (NASA) Fiscal Year 2010 (FY10) budget introduced a new strategic plan that placed renewed emphasis on advanced missions beyond Earth orbit. This supports NASA s 2011 strategic goal to create innovative new space technologies for our exploration, science, and economic future. As a result of this focus on undertaking many and more complex missions, NASA placed its attention on a greater investment in technology development, and this shift resulted in the establishment of the Technology Demonstrations Missions (TDM) Program. The TDM Program, within the newly formed NASA Office of the Chief Technologist, supports NASA s grand challenges by providing a steady cadence of advanced space technology demonstrations (Figure 1), allowing the infusion of flexible path capabilities for future exploration. The TDM Program's goal is to mature crosscutting capabilities to flight readiness in support of multiple future space missions, including flight test projects where demonstration is needed before the capability can transition to direct mission The TDM Program has several unique criteria that set it apart from other NASA program offices. For instance, the TDM Office matures a small number of technologies that are of benefit to multiple customers to flight technology readiness level (TRL) 6 through relevant environment testing on a 3-year development schedule. These technologies must be crosscutting, which is defined as technology with potential to benefit multiple mission directorates, other government agencies, or the aerospace industry, and they must capture significant public interest and awareness. These projects will rely heavily on industry partner collaboration, and funding is capped for all elements of the flight test demonstration including planning, hardware development, software development, launch costs, ground operations, and post-test assessments. In order to inspire collaboration across government and industry

  20. Usage of Wifi Technology for PLC Programming

    Directory of Open Access Journals (Sweden)

    Jaromír ŠKUTA

    2009-06-01

    Full Text Available This contribution describes usage of WIFI technology for programming and parameterization of application in PLC. INSYS WLAN unit from the Microelectronics INSYS Corporation is the base of application. Software access point with using USB WIFI component WL167 is running in industrial PC. Particular PC clients are connecting into network infrastructure PLC by the help of this access point and INSYS WLAN unit. This connection allows configuring and uploading program into this PLC.

  1. Geothermal Technologies Program Blue Ribbon Panel Recommendations

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-06-17

    The Geothermal Technologies Program assembled a geothermal Blue Ribbon Panel on March 22-23, 2011 in Albuquerque, New Mexico for a guided discussion on the future of geothermal energy in the United States and the role of the DOE Program. The Geothermal Blue Ribbon Panel Report captures the discussions and recommendations of the experts. An addendum is available here: http://www.eere.energy.gov/geothermal/pdfs/gtp_blue_ribbon_panel_report_addendum10-2011.pdf

  2. The Reusable Launch Vehicle Technology Program and the X-33 Advanced Technology Demonstrator

    Science.gov (United States)

    Cook, Stephen A.

    1995-01-01

    The goal of the Reusable Launch Vehicle (RLV) technology program is formulated, and the primary objectives of RLV are listed. RLV technology program implementation phases are outlined. X-33 advanced technology demonstrator is described. Program management is addressed.

  3. Exploration Technology Program plans and directions

    Science.gov (United States)

    Aldrich, A.; Rosen, R.; Craig, M.; Mankins, J. C.

    During the first part of the next century, the United States will return to the Moon to create a permanent lunar base, and, before the year 2019, we will send a human mission to Mars. In addition to these human operations, the Space Exploration Initiative will integrally incorporate robotic lunar and Mars missions. In achieving these efforts to expand human presence and activity in space and also exerted and frontiers of human knowledge, the SEI will require an array of new technologies. Mission architecture definition is still underway, but previous studies indicate that the SEI will require developments in areas such as advanced engines for space transportation, in-space assembly and construction to support permanent basing of exploration systems in space, and advanced surface operations capabilities including adequate levels of power and surface roving vehicles, and technologies to support safely long-duration human operations in space. Plans are now being put into place to implement an Exploration Technology Program (ETP) which will develop the major technologies needed for SEI. In close coordination with other ongoing U.S. government research and development efforts, the ETP will provide in the near term clear demonstrations of potential exploration technologies, research results to support SEI architecture decisions, and a foundation of mature technology that is ready to be applied in the first round of SEI missions. In addition to the technology needed for the first round of SEI missions, the ETP will also put in place a foundation of research for longer-term technology needs—ultimately leading the human missions to Mars. The Space Exploration Initiative and the Exploration Technology Program will challenge the best and the brightest minds across government, industry and academia, inspiring students of all ages and making possible future terrestial applications of SEI technologies that may create whole new industries for the future.

  4. Maternal dietary free or bound fructose diversely influence developmental programming of lipogenesis.

    Science.gov (United States)

    Yuruk, Armagan Aytug; Nergiz-Unal, Reyhan

    2017-12-01

    Maternal dietary choices throughout preconception, pregnancy, and lactation irreversibly affect the development of fetal tissues and organs, known as fetal programming. Recommendations tend to emphasize reducing added sugars. However, the impact of maternal dietary free or bound fructose in added sugars on developmental programming of lipogenesis is unknown. Virgin Sprague-Dawley rats were randomly divided into five groups. Rats were given feed and plain water (control) or water containing maltodextrin (vehicle), fructose, high-fructose corn syrup (HFCS) containing 55% fructose, sucrose (20% w/v) for 12 weeks before mating and throughout the pregnancy and lactation periods. Body weight, water, and feed intake were measured throughout the study. At the end of the lactation period, blood was drawn to determine the fasting levels of glucose, insulin, triglycerides, and non-esterified fatty acids (NEFA) in blood. Triglycerides and acetyl Co-A Carboxylase-1 (ACC1) levels in livers were analyzed, and insulin resistance was calculated. The energy intake of dams in the HFCS group was higher than in the fructose group, while weight gain was less in the HFCS group than in the fructose group. HFCS resulted in greater insulin resistance in dams, whereas free fructose had a robust effect on the fetal programming of insulin resistance. Free fructose and HFCS in the maternal diet increased blood and liver triglycerides and NEFA content in pups. Furthermore, fructose and HFCS exposure increased phosphorylated ACC1 as compared to maltodextrin and control, indicating greater fatty acid synthesis in pups and dams. Different types of added sugar in the maternal diet have different metabolic effects on the developmental programming of lipogenesis. Consequently, high fructose intake via processed foods may increase the risk for chronic diseases, and free fructose might contribute to developmental programming of chronic diseases more than bound fructose.

  5. Heavy Vehicle Technologies Program Retrospective and Outlook

    International Nuclear Information System (INIS)

    James J. Eberhardt

    1999-01-01

    OHVT Mission is to conduct, in collaboration with our heavy vehicle industry partners and their suppliers, a customer-focused national program to research and develop technologies that will enable trucks and other heavy vehicles to be more energy efficient and able to use alternative fuels while simultaneously reducing emissions

  6. A Technology Program that Rescues Spacecraft

    Science.gov (United States)

    Deutsch, Leslie J.; Lesh, J. R.

    2004-03-01

    There has never been a long-duration deep space mission that did not have unexpected problems during operations. JPL's Interplanetary Network Directorate (IND) Technology Program was created to develop new and improved methods of communication, navigation, and operations. A side benefit of the program is that it maintains a cadre of human talent and experimental systems that can be brought to bear on unexpected problems that may occur during mission operations. Solutions fall into four categories: applying new technology during operations to enhance science performance, developing new operational strategies, providing domain experts to help find solutions, and providing special facilities to trouble-shoot problems. These are illustrated here using five specific examples of spacecraft anomalies that have been solved using, at least in part, expertise or facilities from the IND Technology Program: Mariner 10, Voyager, Galileo, SOHO, and Cassini/Huygens. In this era of careful cost management, and emphasis on returns-on-investment, it is important to recognize this crucial additional benefit from such technology program investments.

  7. Application of Statistics in Engineering Technology Programs

    Science.gov (United States)

    Zhan, Wei; Fink, Rainer; Fang, Alex

    2010-01-01

    Statistics is a critical tool for robustness analysis, measurement system error analysis, test data analysis, probabilistic risk assessment, and many other fields in the engineering world. Traditionally, however, statistics is not extensively used in undergraduate engineering technology (ET) programs, resulting in a major disconnect from industry…

  8. OVERVIEW OF USEPA'S ARSENIC TECHNOLOGY DEMONSTRATION PROGRAM

    Science.gov (United States)

    This presentation provides a summary on the Arsenic Treatment Technology Demonstration Program. The information includes the history and the current status of the demonstration projects on both round 1 and round 2 including some photos of the treatment systems. The presentation m...

  9. 75 FR 10464 - Broadband Technology Opportunities Program

    Science.gov (United States)

    2010-03-08

    ... window for Public Computer Center (PCC) and Sustainable Broadband Adoption (SBA) projects. DATES: All...; Extension of Application Closing Deadline for Comprehensive Community Infrastructure (CCI) Projects. SUMMARY... Infrastructure (CCI) projects under the Broadband Technology Opportunities Program (BTOP) is extended until 5:00...

  10. Commercial technologies from the SP-100 program

    International Nuclear Information System (INIS)

    Truscello, V.C.; Fujita, T.; Mondt, J.F.

    1995-01-01

    For more than a decade, Jet Propulsion Labortory and Los Alamos have managed a multi-agency funded effort to develop a space reactor power system. This SP-100 Program has developed technologies required for space power systems that can be implemented in the industrial and commercial sectors to improve competitiveness in the global economy. Initial steps taken to transfer this technology from the laboratories to industrial and commercial entities within United States include: (1) identifying specific technologies having commercial potential; (2) distributing information describing the identified technologies and interacting with interested commercial and industrial entities to develop application-specific details and requirements; and (3) providing a technological data base that leads to transfer of technology or the forming of teaming arrangements to accomplish the transfer by tailoring the technology to meet application-specific requirements. SP-100 technologies having commercial potential encompass fabrication processes, devices, and components. Examples: a process for bonding refractory metals to graphite, a device to sense the position of an actuator and a component to enable rotating machines to operate without supplying lubrication (self-lubricating ball bearing). Shortly after the NASA Regional Technology Transfer Centers widely disseminated information covering SP-100 technologies, over one hundred expressions of interest were received, which indicate that there is a large potential benefit in transferring SP-100 technology. Interactions with industrial and commercial entities have identified a substantial need for creating teaming arrangements involving the interested entity and personnel from laboratories and their contractors, who have the knowledge and ability to tailor the technology to meet application-specific requirements. copyright 1995 American Institute of Physics

  11. Self-Report Computer-Based Survey of Technology Use by People with Intellectual and Developmental Disabilities

    Science.gov (United States)

    Tanis, Emily Shea; Palmer, Susan; Wehmeyer, Michael; Davies, Daniel K.; Stock, Steven E.; Lobb, Kathy; Bishop, Barbara

    2012-01-01

    Advancements of technologies in the areas of mobility, hearing and vision, communication, and daily living for people with intellectual and developmental disabilities has the potential to greatly enhance independence and self-determination. Previous research, however, suggests that there is a technological divide with regard to the use of such…

  12. First Wall, Blanket, Shield Engineering Technology Program

    International Nuclear Information System (INIS)

    Nygren, R.E.

    1982-01-01

    The First Wall/Blanket/Shield Engineering Technology Program sponsored by the Office of Fusion Energy of DOE has the overall objective of providing engineering data that will define performance parameters for nuclear systems in advanced fusion reactors. The program comprises testing and the development of computational tools in four areas: (1) thermomechanical and thermal-hydraulic performance of first-wall component facsimiles with emphasis on surface heat loads; (2) thermomechanical and thermal-hydraulic performance of blanket and shield component facsimiles with emphasis on bulk heating; (3) electromagnetic effects in first wall, blanket, and shield component facsimiles with emphasis on transient field penetration and eddy-current effects; (4) assembly, maintenance and repair with emphasis on remote-handling techniques. This paper will focus on elements 2 and 4 above and, in keeping with the conference participation from both fusion and fission programs, will emphasize potential interfaces between fusion technology and experience in the fission industry

  13. The reusable launch vehicle technology program

    Science.gov (United States)

    Cook, S.

    1995-01-01

    Today's launch systems have major shortcomings that will increase in significance in the future, and thus are principal drivers for seeking major improvements in space transportation. They are too costly; insufficiently reliable, safe, and operable; and increasingly losing market share to international competition. For the United States to continue its leadership in the human exploration and wide ranging utilization of space, the first order of business must be to achieve low cost, reliable transportatin to Earth orbit. NASA's Access to Space Study, in 1993, recommended the development of a fully reusable single-stage-to-orbit (SSTO) rocket vehicle as an Agency goal. The goal of the Reusable Launch Vehicle (RLV) technology program is to mature the technologies essential for a next-generation reusable launch system capable of reliably serving National space transportation needs at substantially reduced costs. The primary objectives of the RLV technology program are to (1) mature the technologies required for the next-generation system, (2) demonstrate the capability to achieve low development and operational cost, and rapid launch turnaround times and (3) reduce business and technical risks to encourage significant private investment in the commercial development and operation of the next-generation system. Developing and demonstrating the technologies required for a Single Stage to Orbit (SSTO) rocket is a focus of the program becuase past studies indicate that it has the best potential for achieving the lowest space access cost while acting as an RLV technology driver (since it also encompasses the technology requirements of reusable rocket vehicles in general).

  14. The reusable launch vehicle technology program

    Science.gov (United States)

    Cook, S.

    Today's launch systems have major shortcomings that will increase in significance in the future, and thus are principal drivers for seeking major improvements in space transportation. They are too costly; insufficiently reliable, safe, and operable; and increasingly losing market share to international competition. For the United States to continue its leadership in the human exploration and wide ranging utilization of space, the first order of business must be to achieve low cost, reliable transportatin to Earth orbit. NASA's Access to Space Study, in 1993, recommended the development of a fully reusable single-stage-to-orbit (SSTO) rocket vehicle as an Agency goal. The goal of the Reusable Launch Vehicle (RLV) technology program is to mature the technologies essential for a next-generation reusable launch system capable of reliably serving National space transportation needs at substantially reduced costs. The primary objectives of the RLV technology program are to (1) mature the technologies required for the next-generation system, (2) demonstrate the capability to achieve low development and operational cost, and rapid launch turnaround times and (3) reduce business and technical risks to encourage significant private investment in the commercial development and operation of the next-generation system. Developing and demonstrating the technologies required for a Single Stage to Orbit (SSTO) rocket is a focus of the program becuase past studies indicate that it has the best potential for achieving the lowest space access cost while acting as an RLV technology driver (since it also encompasses the technology requirements of reusable rocket vehicles in general).

  15. Overview of international fusion technology programs

    International Nuclear Information System (INIS)

    Coffman, F.E.; Baublitz, J.E.; Beard, D.S.; Cohen, M.M.; Dalder, E.N.C.; Finfgeld, C.R.; Haas, G.M.; Head, C.R.; Murphy, M.R.; Nardella, G.R.

    1979-01-01

    World fusion technology programs, as well as current progress and future plans for the U.S., are discussed. Regarding conceptual design, the international INTOR tokamak study, the Garching Ignition Test Reactor Study, the U.S. Engineering Test Facility conceptual design, the Argonne National Laboratory Commercial Tokamak Study, mirror conceptual designs, and alternate concepts and applications studies are summarized. With regard to magnetics, progress to date in the large coil program and pulsed coil program is summarized. In the area of plasma heating and fueling and exhaust, work on a new positive ion source research and development program at Lawrence Berkeley Laboratory and Oak Ridge National Laboratory is described, as is negative ion work. Tradeoff considerations for radio-frequency heating alternatives are made, and a new 60-100 GHz electron cyclotron heating research and development program is discussed. Progress and plans for solid hydrogen pellet injector development are analyzed, as are plans for a divertor technology initiative. A brief review of the U.S. alternate applications and environment and safety program is included

  16. Wilberforce Power Technology in Education Program

    Science.gov (United States)

    Gordon, Edward M.; Buffinger, D. R.; Hehemann, D. G.; Breen, M. L.; Raffaelle, R. P.

    1999-01-01

    The Wilberforce Power Technology in Education Program is a multipart program. Three key parts of this program will be described. They are: (1) WISE-The Wilberforce Summer Intensive Experience. This annual offering is an educational program which is designed to provide both background reinforcement and a focus on study skills to give the participants a boost in their academic performance throughout their academic careers. It is offered to entering Wilberforce students. Those students who take advantage of WISE learn to improve important skills which enable them to work at higher levels in mathematics, science and engineering courses throughout their college careers, but most notably in the first year of college study. (2) Apply technology to reaming. This is being done in several ways including creating an electronic chemistry text with hypertext links to a glossary to help the students deal with the large new vocabulary required to describe and understand chemistry. It is also being done by converting lecture materials for the Biochemistry class to PowerPoint format. Technology is also being applied to learning by exploring simulation software of scientific instrumentation. (3) Wilberforce participation in collaborative research with NASA's John H. Glenn Research Center at Lewis Field. This research has focused on two areas in the past year. The first of these is the deposition of solar cell materials. A second area involves the development of polymeric materials for incorporation into thin film batteries.

  17. D and D technology development program

    International Nuclear Information System (INIS)

    Hyde, J.M.

    1998-01-01

    This paper describes the content of the current program of work for the Deactivation and Decommissioning Focus Area (DDFA) located in the Office of Science and Technology (EM-50). The authors began using large-scale demonstration projects (LSDPs) in 1996 to demonstrate and test innovative decommissioning and decontamination (D and D) technologies in ongoing US Department of Energy (DOE) decommissioning projects. These LSDPs have been conducted in and are planned for different types of DOE facilities such as research and production reactors; highly enriched uranium, tritium, and plutonium processing facilities; fuel reprocessing canyons; weapons production facilities; gaseous diffusion plants; hot cells; and waste processing facilities. The concept has been to focus on addressing DOE's high-priority deactivation and decommissioning needs through the LSDP strategy. In an LSDP, the focus area demonstrates improved technologies side by side with the current baseline technologies in ongoing site decommissioning projects. This approach helps reduce the risk and liability for the DOE users associated with the first-time use of a technology and promotes creative solutions that expand the D and D tool box beyond standard practices and technologies along with other benefits. As of January 1998, more than 50 technologies have been demonstrated covering the areas of characterization, decontamination, dismantlement, waste disposition, stabilization, and health and safety

  18. Developmental programming: impact of prenatal testosterone excess on pre- and postnatal gonadotropin regulation in sheep.

    Science.gov (United States)

    Manikkam, Mohan; Thompson, Robert C; Herkimer, Carol; Welch, Kathleen B; Flak, Jonathan; Karsch, Fred J; Padmanabhan, Vasantha

    2008-04-01

    The goal of this study was to explore mechanisms that mediate hypersecretion of LH and progressive loss of cyclicity in female sheep exposed during fetal life to excess testosterone. Our working hypothesis was that prenatal testosterone excess, by its androgenic action, amplifies GnRH-induced LH (but not FSH) secretion and, thus, hypersecretion of LH in adulthood, and that this results from altered developmental gene expression of GnRH and estradiol (E2) receptors, gonadotropin subunits, and paracrine factors that differentially regulate LH and FSH synthesis. We observed that, relative to controls, females exposed during fetal life to excess testosterone, as well as the nor-aromatizable androgen dihydrotestosterone, exhibited enhanced LH but not FSH responses to intermittent delivery of GnRH boluses under conditions in which endogenous LH (GnRH) pulses were suppressed. Luteinizing hormone hypersecretion was more evident in adults than in prepubertal females, and it was associated with development of acyclicity. Measurement of pituitary mRNA concentrations revealed that prenatal testosterone excess induced developmental changes in gene expression of pituitary GnRH and E2 receptors and paracrine modulators of LH and FSH synthesis in a manner consistent with subsequent amplification of LH release. Together, this series of studies suggests that prenatal testosterone excess, by its androgenic action, amplifies GnRH-induced LH response, leading to LH hypersecretion and acyclicity in adulthood, and that this programming involves developmental changes in expression of pituitary genes involved in LH and FSH release.

  19. Maternal undernutrition and fetal developmental programming of obesity: the glucocorticoid connection.

    Science.gov (United States)

    Correia-Branco, Ana; Keating, Elisa; Martel, Fátima

    2015-02-01

    An adequate maternal nutrition during pregnancy is crucial for the health outcome of offspring in adulthood. Maternal undernutrition during critical periods of fetal development can program the fetus for metabolic syndrome (MetS) later in life, especially when postnatally challenged with a hypernutritive diet. Adipogenesis, which begins in utero and accelerates in neonatal life, is a major candidate for developmental programming. During fetal development, the hypothalamic-pituitary-adrenal (HPA) axis is extremely susceptible to programming, and the HPA tone is increased throughout life in undernourished conditions. As a consequence, an alteration in the expression and function of glucocorticoid (GC) receptors and of the major GC regulatory enzymes (11β-hydroxysteroid dehydrogenase 1 and -2) occurs. In this review, we will give insights into the role of maternoplacental adverse interactions under the specific context of maternal undernutrition, for later-in-life MetS development, with a special emphasis on the role of GCs. © The Author(s) 2014.

  20. Parental experiences of a developmentally focused care program for infants and children during prolonged hospitalization.

    Science.gov (United States)

    So, Stephanie; Rogers, Alaine; Patterson, Catherine; Drew, Wendy; Maxwell, Julia; Darch, Jane; Hoyle, Carolyn; Patterson, Sarah; Pollock-BarZiv, Stacey

    2014-06-01

    This study investigates parental experiences and perceptions of the care received during their child's prolonged hospitalization. It relates this care to the Beanstalk Program (BP), a develop-mentally focused care program provided to these families within an acute care hospital setting. A total of 20 parents (of children hospitalized between 1-15 months) completed the Measures of Processes of Care (MPOC-20) with additional questions regarding the BP. Scores rate the extent of the health-care provider's behaviour as perceived by the family, ranging from 'to a great extent' (7) to 'never' (1). Parents rated Respectful and Supportive Care (6.33) as highest, while Providing General Information (5.65) was rated lowest. Eleven parents participated in a follow-up, qualitative, semi-structured interview. Interview data generated key themes: (a) parents strive for positive and normal experiences for their child within the hospital environment; (b) parents value the focus on child development in the midst of their child's complex medical care; and (c) appropriate developmentally focused education helps parents shift from feeling overwhelmed with a medically ill child to instilling feelings of confidence and empowerment to care for their child and transition home. These results emphasize the importance of enhancing child development for hospitalized infants and young children through programs such as the BP. © The Author(s) 2013.

  1. Building technologies program. 1995 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Selkowitz, S.E.

    1996-05-01

    The 1995 annual report discusses laboratory activities in the Building Technology Program. The report is divided into four categories: windows and daylighting, lighting systems, building energy simulation, and advanced building systems. The objective of the Building Technologies program is to assist the U.S. building industry in achieving substantial reductions in building-sector energy use and associated greenhouse gas emissions while improving comfort, amenity, health, and productivity in the building sector. Past efforts have focused on windows and lighting, and on the simulation tools needed to integrate the full range of energy efficiency solutions into achievable, cost-effective design solutions for new and existing buildings. Current research is based on an integrated systems and life-cycle perspective to create cost-effective solutions for more energy-efficient, comfortable, and productive work and living environments. Sixteen subprograms are described in the report.

  2. The space shuttle program technologies and accomplishments

    CERN Document Server

    Sivolella, Davide

    2017-01-01

    This book tells the story of the Space Shuttle in its many different roles as orbital launch platform, orbital workshop, and science and technology laboratory. It focuses on the technology designed and developed to support the missions of the Space Shuttle program. Each mission is examined, from both the technical and managerial viewpoints. Although outwardly identical, the capabilities of the orbiters in the late years of the program were quite different from those in 1981. Sivolella traces the various improvements and modifications made to the shuttle over the years as part of each mission story. Technically accurate but with a pleasing narrative style and simple explanations of complex engineering concepts, the book provides details of many lesser known concepts, some developed but never flown, and commemorates the ingenuity of NASA and its partners in making each Space Shuttle mission push the boundaries of what we can accomplish in space. Using press kits, original papers, newspaper and magazine articles...

  3. Mixed Waste Integrated Program emerging technology development

    International Nuclear Information System (INIS)

    Berry, J.B.; Hart, P.W.

    1994-01-01

    The US Department of Energy (DOE) is responsible for the management and treatment of its mixed low-level wastes (MLLW). MLLW are regulated under both the Resource Conservation and Recovery Act and various DOE orders. Over the next 5 years, DOE will manage over 1.2 m 3 of MLLW and mixed transuranic (MTRU) wastes. In order to successfully manage and treat these mixed wastes, DOE must adapt and develop characterization, treatment, and disposal technologies which will meet performance criteria, regulatory approvals, and public acceptance. Although technology to treat MLLW is not currently available without modification, DOE is committed to developing such treatment technologies and demonstrating them at the field scale by FY 1997. The Office of Research and Development's Mixed Waste Integrated Program (MWIP) within the DOE Office of Environmental Management (EM), OfFice of Technology Development, is responsible for the development and demonstration of such technologies for MLLW and MTRU wastes. MWIP advocates and sponsors expedited technology development and demonstrations for the treatment of MLLW

  4. Mixed Waste Integrated Program emerging technology development

    Energy Technology Data Exchange (ETDEWEB)

    Berry, J.B. [Oak Ridge National Lab., TN (United States); Hart, P.W. [USDOE, Washington, DC (United States)

    1994-06-01

    The US Department of Energy (DOE) is responsible for the management and treatment of its mixed low-level wastes (MLLW). MLLW are regulated under both the Resource Conservation and Recovery Act and various DOE orders. Over the next 5 years, DOE will manage over 1.2 m{sup 3} of MLLW and mixed transuranic (MTRU) wastes. In order to successfully manage and treat these mixed wastes, DOE must adapt and develop characterization, treatment, and disposal technologies which will meet performance criteria, regulatory approvals, and public acceptance. Although technology to treat MLLW is not currently available without modification, DOE is committed to developing such treatment technologies and demonstrating them at the field scale by FY 1997. The Office of Research and Development`s Mixed Waste Integrated Program (MWIP) within the DOE Office of Environmental Management (EM), OfFice of Technology Development, is responsible for the development and demonstration of such technologies for MLLW and MTRU wastes. MWIP advocates and sponsors expedited technology development and demonstrations for the treatment of MLLW.

  5. Tank farm waste characterization Technology Program Plan

    International Nuclear Information System (INIS)

    Hohl, T.M.; Schull, K.E.; Bensky, M.S.; Sasaki, L.M.

    1989-03-01

    This document presents technological and analytical methods development activities required to characterize, process, and dispose of Hanford Site wastes stored in underground waste tanks in accordance with state and federal environmental regulations. The document also lists the need date, current (fiscal year 1989) funding, and estimate of future funding for each task. Also identified are the impact(s) if an activity is not completed. The document integrates these needs to minimize duplication of effort between the various programs involved

  6. Divison of Environmental Control Technology program, 1978

    Energy Technology Data Exchange (ETDEWEB)

    Mott, William E.

    1979-06-01

    This report covers Division of Environmental Control Technology projects in progress during FY 1978, within the Office of the Assistant Secretary for Environment, Department of Energy. It is the second in a planned series of annual reports. The Division of Environmental Control Technology (ECT) continues to support the Assistant Secretary for Environment (EV) in discharging two primary responsibilities: (1) under the Environmental Engineering (EE) Program, the independent overview and assessment of environmental control aspects of both the U.S. Department of Energy's (DOE) research, development, and demonstration (RD and D) programs and the Nation's energy policies, and (2) under the Decontamination and Decommissioning Program, the reduction of potential environmental hazards at the radioactively contaminated sites that are presently owned or were formerly used by the Government. This report presents a short summary of objectives, approach, progress and results, future plans, and a reference bibliography for each research, development, or assessment project within the program areas described above.

  7. IPIRG programs - advances in pipe fracture technology

    International Nuclear Information System (INIS)

    Wilkowski, G.; Olson, R.; Scott, P.

    1997-01-01

    This paper presents an overview of the advances made in fracture control technology as a result of the research performed in the International Piping Integrity Research Group (IPIRG) program. The findings from numerous experiments and supporting analyses conducted to investigate the behavior of circumferentially flawed piping and pipe systems subjected to high-rate loading typical of seismic events are summarized. Topics to be discussed include; (1) Seismic loading effects on material properties, (2) Piping system behavior under seismic loads, (3) Advances in elbow fracture evaluations, and (4) open-quotes Realclose quotes piping system response. The presentation for each topic will be illustrated with data and analytical results. In each case, the state-of-the-art in fracture mechanics prior to the first IPIRG program will be contrasted with the state-of-the-art at the completion of the IPIRG-2 program

  8. IPIRG programs - advances in pipe fracture technology

    Energy Technology Data Exchange (ETDEWEB)

    Wilkowski, G.; Olson, R.; Scott, P. [Batelle, Columbus, OH (United States)

    1997-04-01

    This paper presents an overview of the advances made in fracture control technology as a result of the research performed in the International Piping Integrity Research Group (IPIRG) program. The findings from numerous experiments and supporting analyses conducted to investigate the behavior of circumferentially flawed piping and pipe systems subjected to high-rate loading typical of seismic events are summarized. Topics to be discussed include; (1) Seismic loading effects on material properties, (2) Piping system behavior under seismic loads, (3) Advances in elbow fracture evaluations, and (4) {open_quotes}Real{close_quotes} piping system response. The presentation for each topic will be illustrated with data and analytical results. In each case, the state-of-the-art in fracture mechanics prior to the first IPIRG program will be contrasted with the state-of-the-art at the completion of the IPIRG-2 program.

  9. Developmental programming by androgen affects the circadian timing system in female mice.

    Science.gov (United States)

    Mereness, Amanda L; Murphy, Zachary C; Sellix, Michael T

    2015-04-01

    Circadian clocks play essential roles in the timing of events in the mammalian hypothalamo-pituitary-ovarian (HPO) axis. The molecular oscillator driving these rhythms has been localized to tissues of the HPO axis. It has been suggested that synchrony among these oscillators is a feature of normal reproductive function. The impact of fertility disorders on clock function and the role of the clock in the etiology of endocrine pathology remain unknown. Polycystic ovarian syndrome (PCOS) is a particularly devastating fertility disorder, affecting 5%-10% of women at childbearing age with features including a polycystic ovary, anovulation, and elevated serum androgen. Approximately 40% of these women have metabolic syndrome, marked by hyperinsulinemia, dyslipidemia, and insulin resistance. It has been suggested that developmental exposure to excess androgen contributes to the etiology of fertility disorders, including PCOS. To better define the role of the timing system in these disorders, we determined the effects of androgen-dependent developmental programming on clock gene expression in tissues of the metabolic and HPO axes. Female PERIOD2::luciferase (PER2::LUC) mice were exposed to androgen (dihydrotestosterone [DHT]) in utero (Days 16-18 of gestation) or for 9-10 wk (DHT pellet) beginning at weaning (pubertal androgen excess [PAE]). As expected, both groups of androgen-treated mice had disrupted estrous cycles. Analysis of PER2::LUC expression in tissue explants revealed that excess androgen produced circadian misalignment via tissue-dependent effects on phase distribution. In vitro treatment with DHT differentially affected the period of PER2::LUC expression in tissue explants and granulosa cells, indicating that androgen has direct and tissue-specific effects on clock gene expression that may account for the effects of developmental programming on the timing system. © 2015 by the Society for the Study of Reproduction, Inc.

  10. Clean coal technology: Export finance programs

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    Participation by US firms in the development of Clean Coal. Technology (CCT) projects in foreign countries will help the United States achieve multiple national objectives simultaneously--addressing critical goals related to energy, environmental technology, industrial competitiveness and international trade. US participation in these projects will result in an improved global environment, an improvement in the balance of payments and an increase in US jobs. Meanwhile, host countries will benefit from the development of economically- and environmentally-sound power facilities. The Clean Air Act Amendments of 1990 (Public Law 101-549, Section 409) as supplemented by a requirement in the Energy Policy Act of 1992 (Public Law 102-486, Section 1331(f)) requires that the Secretary of Energy, acting through the Trade Promotion Coordinating Committee Subgroup on Clean Coal Technologies, submit a report to Congress with information on the status of recommendations made in the US Department of Energy, Clean Coal Technology Export Programs, Report to the United States Congress, February 1992. Specific emphasis is placed on the adequacy of financial assistance for export of CCTS. This report fulfills the requirements of the Act. In addition, although this report focuses on CCT power projects, the issues it raises about the financing of these projects are also relevant to other CCT projects such as industrial applications or coal preparation, as well as to a much broader range of energy and environmental technology projects worldwide.

  11. The common marmoset monkey: avenues for exploring the prenatal, placental, and postnatal mechanisms in developmental programming of pediatric obesity.

    Science.gov (United States)

    Riesche, Laren; Tardif, Suzette D; Ross, Corinna N; deMartelly, Victoria A; Ziegler, Toni; Rutherford, Julienne N

    2018-05-01

    Animal models have been critical in building evidence that the prenatal experience and intrauterine environment are capable of exerting profound and permanent effects on metabolic health through developmental programming of obesity. However, despite physiological and evolutionary similarities, nonhuman primate models are relatively rare. The common marmoset monkey ( Callithrix jacchus) is a New World monkey that has been used as a biomedical model for well more than 50 years and has recently been framed as an appropriate model for exploring early-life impacts on later health and disease. The spontaneous, multifactorial, and early-life development of obesity in the common marmoset make it a valuable research model for advancing our knowledge about the role of the prenatal and placental mechanisms involved in developmental programming of obesity. This paper provides a brief overview of obesity in the common marmoset, followed by a discussion of marmoset reproduction and placental characteristics. We then discuss the occurrence and utility of variable intrauterine environments in developmental programming in marmosets. Evidence of developmental programming of obesity will be given, and finally, we put forward future directions and innovations for including the placenta in developmental programming of obesity in the common marmoset.

  12. Laser Science and Technology Program Update 2001

    International Nuclear Information System (INIS)

    Chen, H L; Hackel, L A

    2002-01-01

    The Laser Science and Technology (LSandT) Program's mission is to develop advanced solid-state lasers, optics, materials technologies, and applications to solve problems and create new capabilities of importance to the Nation and the Laboratory. A top, near-term priority is to provide technical support to the National Ignition Facility (NIF) to ensure activation success. LSandT provides the NIF Programs with core competencies and supports its economic viability. The primary objectives of LSandT activities in fiscal year (FY) 2001 have been threefold: (1) to support deployment of hardware and to enhance lasers and optics performance for NIF, (2) to develop advanced solid-state laser systems and optical components for the Department of Energy (DOE) and the Department of Defense (DoD), and (3) to invent, develop, and deliver improved concepts and hardware for other government agencies and U.S. industry. Special efforts have also been devoted to building and maintaining our capabilities in three technology areas: high-power solid-state lasers, high-power optical materials, and applications of advanced lasers

  13. 78 FR 31535 - Assistive Technology Alternative Financing Program

    Science.gov (United States)

    2013-05-24

    ... DEPARTMENT OF EDUCATION Assistive Technology Alternative Financing Program AGENCY: Office of Special Education and Rehabilitative Services, Department of Education. ACTION: Notice. Catalog of Federal... developed for the Assistive Technology (AT) Alternative Financing Program (AFP) in fiscal year (FY) 2012 to...

  14. Shippingport station decommissioning project technology transfer program

    International Nuclear Information System (INIS)

    Pasquini, L.A.

    1986-01-01

    The purpose of the Shippingport Station Decommissioning Project (SSDP) is to place the Shippingport Atomic Power Station in a long-term radiologically safe condition following defueling of the reactor, to perform decommissioning in such a manner as to demonstrate to the nuclear industry the application of decommissioning procedures to a large scale nuclear power plant, and to provide useful planning data for future decommissioning projects. This paper describes the Technology Transfer Program for collecting and archiving the decommissioning data base and its availability to the nuclear industry

  15. Southern California Regional Technology Acceleration Program

    Energy Technology Data Exchange (ETDEWEB)

    Ochoa, Rosibel [Univ. of California, San Diego, CA (United States). Jacobs School of Engineering; Rasochova, Lada [Univ. of California, San Diego, CA (United States). Rady School of Management

    2014-09-30

    UC San Diego and San Diego State University are partnering to address these deficiencies in the renewable energy space in the greater San Diego region, accelerating the movement of clean energy innovation from the university laboratory into the marketplace, building on the proven model of the William J. von Liebig Center’s (vLC’s) Proof of Concept (POC) program and virtualizing the effort to enable a more inclusive environment for energy innovation and expansion of the number of clean energy start-ups and/or technology licenses in greater California.

  16. Superconducting technology program Sandia 1996 annual report

    International Nuclear Information System (INIS)

    Roth, E.P.

    1997-02-01

    Sandia's Superconductivity Technology Program is a thallium-based high-temperature superconductor (HTS) research and development program consisting of efforts in powder synthesis and process development, open-system thick film conductor development, wire and tape fabrication, and HTS motor design. The objective of this work is to develop high-temperature superconducting conductors (wire and tape) capable of meeting requirements for high-power electrical devices of interest to industry. The research efforts currently underway are: (1) Process development and characterization of thallium-based high-temperature superconducting closed system wire and tape, (2) Investigation of the synthesis and processing of thallium-based thick films using two-zone processing, and (3) Cryogenic design of a 30K superconducting motor. This report outlines the research that has been performed during FY96 in each of these areas

  17. Developmental programming: impact of prenatal testosterone excess on ovarian cell proliferation and apoptotic factors in sheep.

    Science.gov (United States)

    Salvetti, Natalia R; Ortega, Hugo H; Veiga-Lopez, Almudena; Padmanabhan, Vasantha

    2012-07-01

    Prenatal testosterone (T) excess leads to reproductive dysfunctions in sheep, which include increased ovarian follicular recruitment and persistence. To test the hypothesis that follicular disruptions in T sheep stem from changes in the developmental ontogeny of ovarian proliferation and apoptotic factors, pregnant Suffolk sheep were injected twice weekly with T propionate or dihydrotestosterone propionate (DHT; a nonaromatizable androgen) from Days 30 to 90 of gestation. Changes in developmental expression of proliferating cell nuclear antigen (PCNA), BCL2, BAX, activated CASP3, and FAS/FASLG were determined at Fetal Days 90 and 140, 22 wk, 10 mo, and 21 mo of age by immunocytochemisty. Prenatal T treatment induced changes in expression of proliferative and apoptotic markers in a follicle-, age-, and steroid-specific manner. Changes in BAX were evident only during fetal life and PCNA, BCL2, and CASP3 only postnatally. Prenatal T and not DHT increased PCNA and decreased BCL2 in granulosa/theca cells of antral follicles at 10 and 21 mo but decreased CASP3 in granulosa/theca cells of antral follicles at 22 wk (prepubertal) and 10 and 21 mo. Both treatments decreased BAX immunostaining in granulosa cells of Fetal Day 90 primordial/primary follicles. Neither treatment affected FAS expression at any developmental time point in any follicular compartment. Effects on BAX appear to be programmed by androgenic actions and PCNA, BCL2, and CASP3 by estrogenic actions of T. Overall, the findings demonstrate that fetal exposure to excess T disrupts the ovarian proliferation/apoptosis balance, thus providing a basis for the follicular disruptions evidenced in these females.

  18. 76 FR 4350 - Health Information Technology Extension Program

    Science.gov (United States)

    2011-01-25

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Information Technology Extension Program ACTION: Public Notice. SUMMARY: This notice announces changes to the Health Information Technology Extension... of the National Coordinator for Health Information Technology, 200 Independence Ave, SW., Suite 729D...

  19. Analysis of Engineering Content within Technology Education Programs

    Science.gov (United States)

    Fantz, Todd D.; Katsioloudis, Petros J.

    2011-01-01

    In order to effectively teach engineering, technology teachers need to be taught engineering content, concepts, and related pedagogy. Some researchers posit that technology education programs may not have enough content to prepare technology teachers to teach engineering design. Certain technology teacher education programs have responded by…

  20. Laser Science and Technology Program Update 2002

    International Nuclear Information System (INIS)

    Hackel, L A; Chen, H L

    2003-01-01

    The Laser Science and Technology (LSandT) Program's mission is to develop advanced lasers, optics, materials technologies, and applications to solve problems and create new capabilities of importance to the nation and the Laboratory. A top, near-term priority is to provide technical support in the deployment and upgrade of the National Ignition Facility (NIF). Our other program activities synergistically develop technologies that are of interest to the NIF Directorate but outside the scope of the NIF funding. The primary objectives of LSandT activities in 2002 have been fourfold--(a) to support deployment of hardware and to enhance laser and optics performance for NIF, (b) to develop high-energy petawatt laser science and technology for the Department of Energy (DOE), (c) to develop advanced solid-state laser systems and optical components for the Department of Defense (DoD), and to invent develop, and deliver improved concepts and hardware for other government agencies and industry. Special efforts have been devoted to building and maintaining our capabilities in three technology areas: high-power short-pulse solid-state lasers, high-power optical materials, and applications of advanced lasers. LSandT activities during 2002 focused on seven major areas: (1) NIF Project--LSandT led major advances in the deployment of NIF Final Optics Assembly (FOA) and the development of 3ω optics processing and treatment technologies to enhance NIF's operations and performance capabilities. (2) Stockpile Stewardship Program (SSP)--LSandT personnel continued development of ultrashort-pulse lasers and high-power, large-aperture optics for applications in SSP, extreme-field science and national defense. To enhance the high-energy petawatt (HEPW) capability in NIF, LSandT continued development of advanced compressor-grating and front-end laser technologies utilizing optical-parametric chirped-pulse amplification (OPCPA). (3) High-energy-density physics and inertial fusion energy

  1. Developmental Immunotoxicity, Perinatal Programming, and Noncommunicable Diseases: Focus on Human Studies

    Science.gov (United States)

    Dietert, Rodney R.

    2014-01-01

    Developmental immunotoxicity (DIT) is a term given to encompass the environmentally induced disruption of normal immune development resulting in adverse outcomes. A myriad of chemical, physical, and psychological factors can all contribute to DIT. As a core component of the developmental origins of adult disease, DIT is interlinked with three important concepts surrounding health risks across a lifetime: (1) the Barker Hypothesis, which connects prenatal development to later-life diseases, (2) the hygiene hypothesis, which connects newborns and infants to risk of later-life diseases and, (3) fetal programming and epigenetic alterations, which may exert effects both in later life and across future generations. This review of DIT considers: (1) the history and context of DIT research, (2) the fundamental features of DIT, (3) the emerging role of DIT in risk of noncommunicable diseases (NCDs) and (4) the range of risk factors that have been investigated through human research. The emphasis on the human DIT-related literature is significant since most prior reviews of DIT have largely focused on animal research and considerations of specific categories of risk factors (e.g., heavy metals). Risk factors considered in this review include air pollution, aluminum, antibiotics, arsenic, bisphenol A, ethanol, lead (Pb), maternal smoking and environmental tobacco smoke, paracetamol (acetaminophen), pesticides, polychlorinated biphenyls, and polyfluorinated compounds. PMID:26556429

  2. Space Technology Mission Directorate Game Changing Development Program FY2015 Annual Program Review: Advanced Manufacturing Technology

    Science.gov (United States)

    Vickers, John; Fikes, John

    2015-01-01

    The Advance Manufacturing Technology (AMT) Project supports multiple activities within the Administration's National Manufacturing Initiative. A key component of the Initiative is the Advanced Manufacturing National Program Office (AMNPO), which includes participation from all federal agencies involved in U.S. manufacturing. In support of the AMNPO the AMT Project supports building and Growing the National Network for Manufacturing Innovation through a public-private partnership designed to help the industrial community accelerate manufacturing innovation. Integration with other projects/programs and partnerships: STMD (Space Technology Mission Directorate), HEOMD, other Centers; Industry, Academia; OGA's (e.g., DOD, DOE, DOC, USDA, NASA, NSF); Office of Science and Technology Policy, NIST Advanced Manufacturing Program Office; Generate insight within NASA and cross-agency for technology development priorities and investments. Technology Infusion Plan: PC; Potential customer infusion (TDM, HEOMD, SMD, OGA, Industry); Leverage; Collaborate with other Agencies, Industry and Academia; NASA roadmap. Initiatives include: Advanced Near Net Shape Technology Integrally Stiffened Cylinder Process Development (launch vehicles, sounding rockets); Materials Genome; Low Cost Upper Stage-Class Propulsion; Additive Construction with Mobile Emplacement (ACME); National Center for Advanced Manufacturing.

  3. Large rotorcraft transmission technology development program

    Science.gov (United States)

    Mack, J. C.

    1983-01-01

    Testing of a U.S. Army XCH-62 HLH aft rotor transmission under NASA Contract NAS 3-22143 was successfully completed. This test establishes the feasibility of large, high power rotorcraft transmissions as well as demonstrating the resolution of deficiencies identified during the HLH advanced technology programs and reported by USAAMRDLTR-77-38. Over 100 hours of testing was conducted. At the 100% design power rating of 10,620 horsepower, the power transferred through a single spiral bevel gear mesh is more than twice that of current helicopter bevel gearing. In the original design of these gears, industry-wide design methods were employed and failures were experienced which identified problem areas unique to gear size. To remedy this technology shortfall, a program was developed to predict gear stresses using finite element analysis for complete and accurate representation of the gear tooth and supporting structure. To validate the finite element methodology gear strain data from the existing U.S. Army HLH aft transmission was acquired, and existing data from smaller gears were made available.

  4. Adolescent developmental issues in Hong Kong: Relevance to positive youth development programs in Hong Kong.

    Science.gov (United States)

    Shek, Daniel T L

    2006-01-01

    Several adolescent developmental issues and problems in Hong Kong are examined in this paper. First, the changing adolescent substance abuse patterns are described. Second, although the overall youth crime trend was relatively stable in the past decade, shoplifting and stealing crimes deserve our concern. Third, adolescent mental health problem is a growing problem. Fourth, statistics show that unhealthy life styles, such as smoking, early sex and moral confusion are issues of concern. Fifth, the proportion of adolescents experiencing economic disadvantage has increased. Sixth, youth unemployment and non-engaged youth are growing problems when the economy of Hong Kong is undergoing re-structuring. Seventh, family and parenting problems in families with adolescents deserve our attention. Finally, the Social Development Index showed that the development of young people has gradually deteriorated in the past decade. These adolescent issues and problems provide useful pointers for designing the positive youth development program financially sponsored by the Hong Kong Jockey Club Charities Trust.

  5. Radiation detection technology assessment program (RADTAP)

    International Nuclear Information System (INIS)

    Smith, D.E.

    1998-01-01

    The U.S. Customs Service and the U.S. Department of Energy (DOE) conducted a technical and operational assessment of gamma ray radiation detection equipment during the period May 5-16, 1997 at a testing facility in North Carolina. The effort was entitled, ''Radiation Detection Technology Assessment Program (RADTAP)'', and was conducted for the purpose of assessing the applicability, sensitivity and robustness of a diverse suite of gamma ray detection and identification equipment for possible use by Customs and other law enforcement agencies. Thirteen companies entered 25 instruments into the assessment program. All detection equipment entered had to exhibit a minimum sensitivity of 20 micro-R per hour (background included) from a Cesium-137 point source. Isotope identifying spectrometers entered were man portable and operable at room temperature with read-out that could be interpreted by non-technical personnel. Radioactive sources used in the assessment included special nuclear material, industrial and health isotopes. Evaluators included Customs inspectors and technical experts from DOE and Customs. No conclusions or recommendations were issued based on the quantitative and qualitative test results, however, the results of the program provided law enforcement agencies with the necessary data to select equipment that best meets their operational needs and budgets. (author)

  6. Development and Implementation of a Mental Health Work Rehabilitation Program: Results of a Developmental Evaluation.

    Science.gov (United States)

    Sylvain, Chantal; Durand, Marie-José; Velasquez Sanchez, Astrid; Lessard, Nathalie; Maillette, Pascale

    2018-05-23

    Purpose Long-term work disability due to common mental disorders (CMDs) is a growing problem. Yet optimal interventions remain unclear and little is known about implementation challenges in everyday practice. This study aimed to support and evaluate, in real time, the development and implementation of a work rehabilitation program (WRP) designed to promote post-CMD return-to-work (RTW). Methods A 2-year developmental evaluation was performed using a participatory approach. At program outset, the researchers held five work meetings to revise the program's logic model and discuss its underlying change theory with clinicians. Data collection tools used throughout the study period were structured charts of activities conducted with workers (n = 41); in-depth interviews with program clinicians and managers (n = 9); and participant observation during work meetings. Quantitative data were analyzed using descriptive statistics. Qualitative data underwent thematic analysis using a processual approach. Results Three types of activity were developed and implemented: individual and group interventions targeting workers, and joint activities targeting partners (physicians, employers, others). While worker-targeted activities were generally implemented as planned, joint activities were sporadic. Analysis of the implementation process revealed five challenges faced by clinicians. Determinants included clinicians, host organization, sociopolitical context and resources provided by the evaluation. Conclusion The program studied is original in that it is based on the best available scientific knowledge, yet adapted to contextual particularities. The identified implementation challenges highlight the need for greater importance to be placed on the external, non-program context to ensure sustainable implementation in everyday practice.

  7. Technology transfer program at the Morgantown Energy Technology Center: FY 87 program report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W.A.; Lessing, K.B.

    1987-10-01

    The Morgantown Energy Technology Center (METC), located in Morgantown, West Virginia, is an energy research center of the US Department of Energy's (DOE's) Office of Fossil Energy. The research and development work is different from research work conducted by other Government agencies. In DOE research, the Government is not the ultimate ''customer'' for the technologies developed; the ''customer'' is business and industry in the private sector. Thus, tehcnology transfer is a fundamental goal of the DOE. The mission of the Fossil Energy program is to enhance the use of the nations's fossil energy resources. METC's mission applies to certain technologies within the broad scope of technologies encompassed by the Office of Fossil Energy. The Government functions as an underwriter of risk and as a catalyst to stimulate the development of technologies and technical information that might otherwise proceed at a slower pace because of the high-risk nature of the research involved. The research programs and priorities are industry driven; the purpose is to address the perceived needs of industry such that industry will ultimately bring the technologies to the commercial market. As evidenced in this report, METC has an active and effective technology transfer program that is incorporated into all aspects of project planning and execution. Technology transfer at METC is a way of life---a part of everyday activities to further this goal. Each person has a charge to communicate the ideas from within METC to those best able to utilize that information. 4 figs., 20 tabs.

  8. Developmental programming of hypothalamic neuronal circuits: impact on energy balance control

    Science.gov (United States)

    Gali Ramamoorthy, Thanuja; Begum, Ghazala; Harno, Erika; White, Anne

    2015-01-01

    The prevalence of obesity in adults and children has increased globally at an alarming rate. Mounting evidence from both epidemiological studies and animal models indicates that adult obesity and associated metabolic disorders can be programmed by intrauterine and early postnatal environment- a phenomenon known as “fetal programming of adult disease.” Data from nutritional intervention studies in animals including maternal under- and over-nutrition support the developmental origins of obesity and metabolic syndrome. The hypothalamic neuronal circuits located in the arcuate nucleus controlling appetite and energy expenditure are set early in life and are perturbed by maternal nutritional insults. In this review, we focus on the effects of maternal nutrition in programming permanent changes in these hypothalamic circuits, with experimental evidence from animal models of maternal under- and over-nutrition. We discuss the epigenetic modifications which regulate hypothalamic gene expression as potential molecular mechanisms linking maternal diet during pregnancy to the offspring's risk of obesity at a later age. Understanding these mechanisms in key metabolic genes may provide insights into the development of preventative intervention strategies. PMID:25954145

  9. Developmental programming of hypothalamic neuronal circuits: impact on energy balance control

    Directory of Open Access Journals (Sweden)

    Thanuja eGali Ramamoorthy

    2015-04-01

    Full Text Available The prevalence of obesity in adults and children has increased globally at an alarming rate. Mounting evidence from both epidemiological studies and animal models indicates that adult obesity and associated metabolic disorders can be programmed by intrauterine and early postnatal environment- a phenomenon known as fetal programming of adult disease. Data from nutritional intervention studies in animals including maternal under- and over-nutrition support the developmental origins of obesity and metabolic syndrome. The hypothalamic neuronal circuits located in the arcuate nucleus controlling appetite and energy expenditure are set early in life and are perturbed by maternal nutritional insults. In this review, we focus on the effects of maternal nutrition in programming permanent changes in these hypothalamic circuits, with experimental evidence from animal models of maternal under- and over-nutrition. We discuss the epigenetic modifications which regulate hypothalamic gene expression as potential molecular mechanisms linking maternal diet during pregnancy to the offspring’s risk of obesity at a later age. Understanding these mechanisms in key metabolic genes may provide insights into the development of preventative intervention strategies.

  10. 2012 DOE Vehicle Technologies Program Annual Merit Review

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-10-26

    The 2012 DOE Hydrogen Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting was held May 14-18, 2012 in Crystal City, Virginia. The review encompassed all of the work done by the Hydrogen Program and the Vehicle Technologies Program: a total of 309 individual activities were reviewed for Vehicle Technologies, by a total of 189 reviewers. A total of 1,473 individual review responses were received for the technical reviews.

  11. [Pervasive developmental disorders screening program in the health areas of Salamanca and Zamora in Spain].

    Science.gov (United States)

    García Primo, P; Santos Borbujo, J; Martín Cilleros, M V; Martínez Velarte, M; Lleras Muñoz, S; Posada de la Paz, M; Canal Bedia, R

    2014-05-01

    To evaluate the results of the Pervasive Developmental Disorders (PDD) screening program currently ongoing in the public health services in the health area of Salamanca and Zamora, Spain, in terms of feasibility, reliability and costs, with the purpose of extending the program at regional and national levels. A total of 54 paediatric teams (nurses and paediatricians) from the provinces of Salamanca and Zamora participated in the training sessions for the PDD Screening Programme in September 2005, and agreed to administer the questionnaire M-CHAT(1) to all parents attending their clinics in any of these two visits: 18 months and/or 24 months within the Well-baby Check-up Program. A total of 9,524 children have participated up to December 2012. Additionally, we evaluated the participation and opinions of the paediatric teams using questionnaires, and costs per positive case have estimated. Out of a total of 852 (8.9%) children determined as PDD high-risk with the M-CHAT questionnaire results, 61 (7.1%) were confirmed as positive with the M-CHAT follow-up interview. Of these, 22 were diagnosed with a PDD and 31 other disorders of childhood onset according to DSM-IV-TR(2). Almost three-quarters (74%) of respondents felt the program was totally feasible, and 22% viable, but with reservations (n=54). This study has been able to show for the first time in Spain, the feasibility of a population-based PDD screening program within the public health system. Training in social and communicative development, and dissemination of the early signs of PDD among paediatricians, as well as the use of the M-CHAT, is essential for progress in the early detection of these disorders. Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  12. Physics of the Cosmos Program Annual Technology Report

    Science.gov (United States)

    Pham, Bruce Thai; Cardiff, Ann H.

    2015-01-01

    What's in this Report? What's New? This fifth Program Annual Technology Report (PATR) summarizes the Programs technology development activities for fiscal year (FY) 2015. The PATR serves four purposes.1. Summarize the technology gaps identified by the astrophysics community;2. Present the results of this years technology gap prioritization by the PCOS Technology Management Board (TMB);3. Report on newly funded PCOS Strategic Astrophysics Technology (SAT) projects; and4. Detail progress, current status, and activities planned for the coming year for all technologies supported by PCOS Supporting Research and Technology (SRT) funding in FY 2015. .

  13. Technology and the environment: supportive resource or barrier for people with developmental disabilities?

    Science.gov (United States)

    Hammel, Joy

    2003-06-01

    , health care professionals can play a role in linking people to such resources as AT-EI and related services and strategies to support community living. Such a shift in focus also enables professionals to validate interdependence; that is, the give-take relationships that people have with each other to support each other [25]. The use of AT-EI by people with developmental disabilities often involves an interdependent relationship in which another person may help set up the environment or technology and, in turn, the consumer can then reciprocate and engage in an activity or a relationship [1]. Health care professionals also need to better understand and take into consideration the social context, its influence on consumers' use or nonuse of AT-EI, and the long-term influence on community living and participation decisions [1]. Nurses can involve important others in the process by listening to and considering their needs, and ensuring that they are informed about options, the benefits of using AT-EI for the consumer and themselves, and how to set up and troubleshoot the AT-EI. In cases where important others are not supportive, health care professionals may be in a position to link the consumer with other consumers and advocacy groups such as Centers for Independent Living or Self Advocates Becoming Empowered that may offer that support as well as membership in a collective community engaged in systems change. Health care professionals can serve as a system interface by linking people to information and resources to make informed decisions [26]. Resources on developmental disability and health, common issues that may occur, and life course planning help people identify functional issues and early signs of accelerated aging and proactively use the environment and technology to stay in living situations of choice. Few health care professionals are well prepared to provide services to people with developmental disabilities as they age; a great need exists for providers of

  14. Computer technology and computer programming research and strategies

    CERN Document Server

    Antonakos, James L

    2011-01-01

    Covering a broad range of new topics in computer technology and programming, this volume discusses encryption techniques, SQL generation, Web 2.0 technologies, and visual sensor networks. It also examines reconfigurable computing, video streaming, animation techniques, and more. Readers will learn about an educational tool and game to help students learn computer programming. The book also explores a new medical technology paradigm centered on wireless technology and cloud computing designed to overcome the problems of increasing health technology costs.

  15. NASA's aviation safety research and technology program

    Science.gov (United States)

    Fichtl, G. H.

    1977-01-01

    Aviation safety is challenged by the practical necessity of compromising inherent factors of design, environment, and operation. If accidents are to be avoided these factors must be controlled to a degree not often required by other transport modes. The operational problems which challenge safety seem to occur most often in the interfaces within and between the design, the environment, and operations where mismatches occur due to ignorance or lack of sufficient understanding of these interactions. Under this report the following topics are summarized: (1) The nature of operating problems, (2) NASA aviation safety research, (3) clear air turbulence characterization and prediction, (4) CAT detection, (5) Measurement of Atmospheric Turbulence (MAT) Program, (6) Lightning, (7) Thunderstorm gust fronts, (8) Aircraft ground operating problems, (9) Aircraft fire technology, (10) Crashworthiness research, (11) Aircraft wake vortex hazard research, and (12) Aviation safety reporting system.

  16. Building Technologies Program Multi-Year Program Plan Research and Development 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for research and development, including residential and commercial integration, lighting, HVAC and water heating, envelope, windows, and analysis tools.

  17. MIxed Waste Integrated Program (MWIP): Technology summary

    International Nuclear Information System (INIS)

    1994-02-01

    The mission of the Mixed Waste Integrated Program (MWIP) is to develop and demonstrate innovative and emerging technologies for the treatment and management of DOE's mixed low-level wastes (MLLW) for use by its customers, the Office of Waste Operations (EM-30) and the Office of Environmental Restoration (EM-40). The primary goal of MWIP is to develop and demonstrate the treatment and disposal of actual mixed waste (MMLW and MTRU). The vitrification process and the plasma hearth process are scheduled for demonstration on actual radioactive waste in FY95 and FY96, respectively. This will be accomplished by sequential studies of lab-scale non-radioactive testing followed by bench-scale radioactive testing, followed by field-scale radioactive testing. Both processes create a highly durable final waste form that passes leachability requirements while destroying organics. Material handling technology, and off-gas requirements and capabilities for the plasma hearth process and the vitrification process will be established in parallel

  18. U.S. ENVIRONMENTAL PROTECTION AGENCY (EPA) ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM: ARSENIC MONITORING TECHNOLOGIES

    Science.gov (United States)

    The U.S. Environmental Protection Agency Environmental Technology Verification (ETV) program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This technology ...

  19. Developmental programming: State-of-the-science and future directions-summary from a Pennington biomedical symposium

    Science.gov (United States)

    On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current s...

  20. Developing and Implementing a Postsecondary Education Program for Young Adults with Intellectual and Developmental Disabilities: Processes and Procedure

    Science.gov (United States)

    Francis, Grace L.; Gordon, Sarah; Kliethermes, Andrew J.; Regester, April; Baldini, Deborah; Grant, Amber

    2018-01-01

    Postsecondary education programs (PSEs) for young adults with intellectual and developmental disabilities in colleges and universities expand opportunities for these young adults and result in positive outcomes, including employment and improved social networks. Although participating in postsecondary education results in numerous benefits for…

  1. Effectiveness of a Caregiver Education Program on Providing Oral Care to Individuals with Intellectual and Developmental Disabilities

    Science.gov (United States)

    Fickert, Nancy A.; Ross, Diana

    2012-01-01

    Caregivers who work in community living arrangements or intermediate care facilities are responsible for the oral hygiene of individuals with intellectual and developmental disabilities. Oral hygiene training programs do not exist in many organizations, despite concerns about the oral care of this population. The purpose of this study was to…

  2. Developmental Math Programs in California Community College: An Analysis of Math Boot Camp at Cosumnes River College

    Science.gov (United States)

    Powell, Torence J.

    2017-01-01

    The California Community College system, as an open access institution, is tasked with helping students who possess math skills far below college-level complete math course requirements for obtaining an associate degree or transfer to a university. Colleges have created various developmental math programs to achieve this mission; this paper…

  3. A Music Program for Training Head Start Teachers Using a Sequential, Cognitive, Developmental Process with Pre-school Children.

    Science.gov (United States)

    Brodhecker, Shirley G.

    This practicum report addresses the need to supply Head Start teachers with: (1) specific preschool music objectives; (2) a sequential preschool developmental program in music to match the child's cognitive level; (3) how to choose instructional material to encourage specific basic school readiness skills; and (4) workshops to accomplish these…

  4. Program strategy document for the Nuclear Materials Transportation Technology Center

    International Nuclear Information System (INIS)

    Jefferson, R.M.

    1979-07-01

    A multiyear program plan is presented which describes the program of the Nuclear Materials Transportation Technology Center (TIC) at Sandia Laboratories. The work element plans, along with their corresponding work breakdown structures, are presented for TTC activities in the areas of Technology and Information Center, Systems Development, Technology, and Institutional Issues for the years from 1979 to 1985

  5. An integrated strategy for analyzing the unique developmental programs of different myoblast subtypes.

    Directory of Open Access Journals (Sweden)

    2006-02-01

    Full Text Available An important but largely unmet challenge in understanding the mechanisms that govern the formation of specific organs is to decipher the complex and dynamic genetic programs exhibited by the diversity of cell types within the tissue of interest. Here, we use an integrated genetic, genomic, and computational strategy to comprehensively determine the molecular identities of distinct myoblast subpopulations within the Drosophila embryonic mesoderm at the time that cell fates are initially specified. A compendium of gene expression profiles was generated for primary mesodermal cells purified by flow cytometry from appropriately staged wild-type embryos and from 12 genotypes in which myogenesis was selectively and predictably perturbed. A statistical meta-analysis of these pooled datasets--based on expected trends in gene expression and on the relative contribution of each genotype to the detection of known muscle genes--provisionally assigned hundreds of differentially expressed genes to particular myoblast subtypes. Whole embryo in situ hybridizations were then used to validate the majority of these predictions, thereby enabling true-positive detection rates to be estimated for the microarray data. This combined analysis reveals that myoblasts exhibit much greater gene expression heterogeneity and overall complexity than was previously appreciated. Moreover, it implicates the involvement of large numbers of uncharacterized, differentially expressed genes in myogenic specification and subsequent morphogenesis. These findings also underscore a requirement for considerable regulatory specificity for generating diverse myoblast identities. Finally, to illustrate how the developmental functions of newly identified myoblast genes can be efficiently surveyed, a rapid RNA interference assay that can be scored in living embryos was developed and applied to selected genes. This integrated strategy for examining embryonic gene expression and function provides

  6. Nonhuman primate breath volatile organic compounds associate with developmental programming and cardio-metabolic status.

    Science.gov (United States)

    Bishop, Andrew C; Libardoni, Mark; Choudary, Ahsan; Misra, Biswapriya Biswavas; Lange, Kenneth; Bernal, John; Nijland, Mark; Li, Cun; Olivier, Michael; Nathanielsz, Peter W; Cox, Laura A

    2018-03-29

    Rodent and nonhuman primate (NHP) studies indicate that developmental programming by reduced perinatal nutrition negatively impacts life course cardio-metabolic health. We have developed a baboon model in which we feed control mothers (CON) ad libitum while nutrient restricted mothers are fed 70% of ad libitum global feed in pregnancy and lactation. Offspring of nutrient restricted mothers are intrauterine growth restricted (IUGR) at term. By 3.5 years IUGR baboons showed signs of insulin resistance, indicating a pre-diabetic phenotype, in contrast to healthy CON offspring. We hypothesized that a novel breath analysis approach would provide markers of the altered cardio-metabolic state in a non-invasive manner. Here we assess whether exhaled breath volatile organic compounds (VOCs) collected from this unique cohort of juvenile baboons with documented cardio-metabolic dysfunction resulting from in utero programming can be detected from their breath signatures. Breath was collected from male and female CON and IUGR baboons at 4.8±0.2 years (human equivalent ~13 years). Breath VOCs were quantified using a two-dimensional gas chromatography mass spectrometer (2D GC-MS). Two-way ANOVA, on 76 biologically relevant VOCs identified 27 VOCs (p<0.05) with altered abundances between groups (sex, birthweight, and sex x birthweight). The 27 VOCs included 2-pentanone, 2-octanone, 2,5,5 trimethyl-1-hexene and 2,2-dimethyl-undecane, which have not previously been associated with cardio-metabolic disease. Unsupervised principal component analysis of these VOCs could discriminate the four defined clusters defining males, females, CON and IUGR. This study, which is the first to assess quantifiable breath signatures associated with cardio-metabolic programing for any model of IUGR, demonstrates the translational value of this unique model to identify metabolites of programmed cardio-metabolic dysfunction in breath signatures. Future studies are required to validate the

  7. Clean Coal Technology Programs: Completed Projects (Volume 2)

    Energy Technology Data Exchange (ETDEWEB)

    Assistant Secretary for Fossil Energy

    2003-12-01

    Annual report on the Clean Coal Technology Demonstration Program (CCTDP), Power Plant Improvement Initiative (PPII), and Clean Coal Power Initiative (CCPI). The report addresses the roles of the programs, implementation, funding and costs, project descriptions, legislative history, program history, environmental aspects, and project contacts. The project descriptions describe the technology and provides a brief summary of the demonstration results.

  8. Prenatal ethanol exposure-induced adrenal developmental abnormality of male offspring rats and its possible intrauterine programming mechanisms

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Hegui; He, Zheng; Zhu, Chunyan; Liu, Lian; Kou, Hao; Shen, Lang [Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071 (China); Wang, Hui, E-mail: wanghui19@whu.edu.cn [Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan 430071 (China); Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071 (China)

    2015-10-01

    Fetal adrenal developmental status is the major determinant of fetal tissue maturation and offspring growth. We have previously proposed that prenatal ethanol exposure (PEE) suppresses fetal adrenal corticosterone (CORT) synthesis. Here, we focused on PEE-induced adrenal developmental abnormalities of male offspring rats before and after birth, and aimed to explore its intrauterine programming mechanisms. A rat model of intrauterine growth retardation (IUGR) was established by PEE (4 g/kg·d). In PEE fetus, increased serum CORT concentration and decreased insulin-like growth factor 1 (IGF1) concentration, with lower bodyweight and structural abnormalities as well as a decreased Ki67 expression (proliferative marker), were observed in the male fetal adrenal cortex. Adrenal glucocorticoid (GC)-metabolic activation system was enhanced while gene expression of IGF1 signaling pathway with steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase (3β-HSD) was decreased. Furthermore, in the male adult offspring of PEE, serum CORT level was decreased but IGF1 was increased with partial catch-up growth, and Ki67 expression demonstrated no obvious change. Adrenal GC-metabolic activation system was inhibited, while IGF1 signaling pathway and 3β-HSD was enhanced with the steroidogenic factor 1 (SF1), and StAR was down-regulated in the adult adrenal. Based on these findings, we propose a “two-programming” mechanism for PEE-induced adrenal developmental toxicity: “the first programming” is a lower functional programming of adrenal steroidogenesis, and “the second programming” is GC-metabolic activation system-related GC-IGF1 axis programming. - Highlights: • Prenatal ethanol exposure induces adrenal developmental abnormality in offspring rats. • Prenatal ethanol exposure induces intrauterine programming of adrenal steroidogenesis. • Intrauterine GC-IGF1 axis programming might mediate adrenal developmental abnormality.

  9. Prenatal ethanol exposure-induced adrenal developmental abnormality of male offspring rats and its possible intrauterine programming mechanisms

    International Nuclear Information System (INIS)

    Huang, Hegui; He, Zheng; Zhu, Chunyan; Liu, Lian; Kou, Hao; Shen, Lang; Wang, Hui

    2015-01-01

    Fetal adrenal developmental status is the major determinant of fetal tissue maturation and offspring growth. We have previously proposed that prenatal ethanol exposure (PEE) suppresses fetal adrenal corticosterone (CORT) synthesis. Here, we focused on PEE-induced adrenal developmental abnormalities of male offspring rats before and after birth, and aimed to explore its intrauterine programming mechanisms. A rat model of intrauterine growth retardation (IUGR) was established by PEE (4 g/kg·d). In PEE fetus, increased serum CORT concentration and decreased insulin-like growth factor 1 (IGF1) concentration, with lower bodyweight and structural abnormalities as well as a decreased Ki67 expression (proliferative marker), were observed in the male fetal adrenal cortex. Adrenal glucocorticoid (GC)-metabolic activation system was enhanced while gene expression of IGF1 signaling pathway with steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase (3β-HSD) was decreased. Furthermore, in the male adult offspring of PEE, serum CORT level was decreased but IGF1 was increased with partial catch-up growth, and Ki67 expression demonstrated no obvious change. Adrenal GC-metabolic activation system was inhibited, while IGF1 signaling pathway and 3β-HSD was enhanced with the steroidogenic factor 1 (SF1), and StAR was down-regulated in the adult adrenal. Based on these findings, we propose a “two-programming” mechanism for PEE-induced adrenal developmental toxicity: “the first programming” is a lower functional programming of adrenal steroidogenesis, and “the second programming” is GC-metabolic activation system-related GC-IGF1 axis programming. - Highlights: • Prenatal ethanol exposure induces adrenal developmental abnormality in offspring rats. • Prenatal ethanol exposure induces intrauterine programming of adrenal steroidogenesis. • Intrauterine GC-IGF1 axis programming might mediate adrenal developmental abnormality.

  10. Powerlessness or Omnipotence – the Impact of Structuring Technologies in Learning Processes for Children with Attention and Developmental Deficits

    DEFF Research Database (Denmark)

    Voldborg, Hanne; Sorensen, Elsebeth Korsgaard

    2016-01-01

    Schoolwork of learners with developmental and attention deficits is often characterized by low productivity, many errors due to carelessness or inattention and poor organizational ability. Focus learners have difficulties performing at the same level as their peers. This paper addresses the chall...... the challenges and investigates the potential of technologies for creating and facilitating environments, where learners are well-supported with respect to overviewing, structuring and planning tasks, evaluating and adjusting participation and management of time....

  11. Technology needs assessment for DOE environmental restoration programs

    International Nuclear Information System (INIS)

    Duray, J.R.; Carlson, T.J.; Carpenter, C.E.; Cummins, L.E.; Daub, G.J.

    1992-01-01

    The 'Technology Needs Assessment Final Report' describes current and planned environmental restoration activity, identifies technologies intended to be used or under consideration, and ranks technology deficiencies in the U.S. Department of Energy's environmental restoration program. Included in the ranking are treatment technologies, characterization technologies, and non-technology issues that affect environmental restoration. Data used for the assessment was gathered during interviews in the spring of 1991 with DOE site personnel responsible for the environmental restoration work. (author)

  12. Comparison of State-Funded Technology Maturation Programs.

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Elizabeth James Kistin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Warren, Drake [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hess, Marguerite Evelyn [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-12-01

    This study examines the structure and impact of state-funded technology maturation programs that leverage research institutions for economic development throughout the United States. The lessons learned and practices identified from previous experiences will inform Sandia National Laboratories' Government Relations and Technology Partnerships teams as they participate in near-term discussions about the proposed Technology Readiness Gross Receipts Tax Credit and Program, and continue to shape longer-term program and partnership opportunities. This Page Intentionally Left Blank

  13. In Situ Remediation Integrated Program: Technology summary

    Energy Technology Data Exchange (ETDEWEB)

    1994-02-01

    The In Situ Remediation Integrated Program (ISR IP) was instituted out of recognition that in situ remediation could fulfill three important criteria: significant cost reduction of cleanup by eliminating or minimizing excavation, transportation, and disposal of wastes; reduced health impacts on workers and the public by minimizing exposure to wastes during excavation and processing; and remediation of inaccessible sites, including: deep subsurfaces, in, under, and around buildings. Buried waste, contaminated soils and groundwater, and containerized wastes are all candidates for in situ remediation. Contaminants include radioactive wastes, volatile and non-volatile organics, heavy metals, nitrates, and explosive materials. The ISR IP intends to facilitate development of in situ remediation technologies for hazardous, radioactive, and mixed wastes in soils, groundwater, and storage tanks. Near-term focus is on containment of the wastes, with treatment receiving greater effort in future years. ISR IP is an applied research and development program broadly addressing known DOE environmental restoration needs. Analysis of a sample of 334 representative sites by the Office of Environmental Restoration has shown how many sites are amenable to in situ remediation: containment--243 sites; manipulation--244 sites; bioremediation--154 sites; and physical/chemical methods--236 sites. This needs assessment is focused on near-term restoration problems (FY93--FY99). Many other remediations will be required in the next century. The major focus of the ISR EP is on the long term development of permanent solutions to these problems. Current needs for interim actions to protect human health and the environment are also being addressed.

  14. In Situ Remediation Integrated Program: Technology summary

    International Nuclear Information System (INIS)

    1994-02-01

    The In Situ Remediation Integrated Program (ISR IP) was instituted out of recognition that in situ remediation could fulfill three important criteria: significant cost reduction of cleanup by eliminating or minimizing excavation, transportation, and disposal of wastes; reduced health impacts on workers and the public by minimizing exposure to wastes during excavation and processing; and remediation of inaccessible sites, including: deep subsurfaces, in, under, and around buildings. Buried waste, contaminated soils and groundwater, and containerized wastes are all candidates for in situ remediation. Contaminants include radioactive wastes, volatile and non-volatile organics, heavy metals, nitrates, and explosive materials. The ISR IP intends to facilitate development of in situ remediation technologies for hazardous, radioactive, and mixed wastes in soils, groundwater, and storage tanks. Near-term focus is on containment of the wastes, with treatment receiving greater effort in future years. ISR IP is an applied research and development program broadly addressing known DOE environmental restoration needs. Analysis of a sample of 334 representative sites by the Office of Environmental Restoration has shown how many sites are amenable to in situ remediation: containment--243 sites; manipulation--244 sites; bioremediation--154 sites; and physical/chemical methods--236 sites. This needs assessment is focused on near-term restoration problems (FY93--FY99). Many other remediations will be required in the next century. The major focus of the ISR EP is on the long term development of permanent solutions to these problems. Current needs for interim actions to protect human health and the environment are also being addressed

  15. Quantitative assessment of developmental levels in overarm throwing using wearable inertial sensing technology.

    Science.gov (United States)

    Grimpampi, Eleni; Masci, Ilaria; Pesce, Caterina; Vannozzi, Giuseppe

    2016-09-01

    Motor proficiency in childhood has been recently recognised as a public health determinant, having a potential impact on the physical activity level and possible sedentary behaviour of the child later in life. Among fundamental motor skills, ballistic skills assessment based on in-field quantitative observations is progressively needed in the motor development community. The aim of this study was to propose an in-field quantitative approach to identify different developmental levels in overarm throwing. Fifty-eight children aged 5-10 years performed an overarm throwing task while wearing three inertial sensors located at the wrist, trunk and pelvis level and were then categorised using a developmental sequence of overarm throwing. A set of biomechanical parameters were defined and analysed using multivariate statistics to evaluate whether they can be used as developmental indicators. Trunk and pelvis angular velocities and time durations before the ball release showed increasing/decreasing trends with increasing developmental level. Significant differences between developmental level pairs were observed for selected biomechanical parameters. The results support the suitability and feasibility of objective developmental measures in ecological learning contexts, suggesting their potential supportiveness to motor learning experiences in educational and youth sports training settings.

  16. U.S. Climate Change Technology Program: Strategic Plan

    National Research Council Canada - National Science Library

    2006-01-01

    .... climate change research and development activities. Under this new structure, climate change science and climate-related technology research programs are integrated to an extent not seen previously...

  17. The United States Advanced Reactor Technologies Research and Development Program

    International Nuclear Information System (INIS)

    O’Connor, Thomas J.

    2014-01-01

    The following aspects are addressed: • Nuclear energy mission; • Reactor research development and deployment (RD&D) programs: - Light Water Reactor Sustainability Program; - Small Modular Reactor Licensing Technical Support; - Advanced Reactor Technologies (ART)

  18. FHWA research and technology evaluation program summary report spring 2016

    Science.gov (United States)

    2016-08-01

    This report summarizes the 16 evaluations being conducted by the Volpe National Transportation Systems Center on behalf of FHWAs Research and Technology Program. The FHWA R&T Program furthers the Turner-Fairbank Highway Research Centers goal of...

  19. Near-Net Forging Technology Demonstration Program

    Science.gov (United States)

    Hall, I. Keith

    1996-01-01

    Significant advantages in specific mechanical properties, when compared to conventional aluminum (Al) alloys, make aluminum-lithium (Al-Li) alloys attractive candidate materials for use in cryogenic propellant tanks and dry bay structures. However, the cost of Al-Li alloys is typically five times that of 2219 aluminum. If conventional fabrication processes are employed to fabricate launch vehicle structure, the material costs will restrict their utilization. In order to fully exploit the potential cost and performance benefits of Al-Li alloys, it is necessary that near-net manufacturing methods be developed to off-set or reduce raw material costs. Near-net forging is an advanced manufacturing method that uses elevated temperature metal movement (forging) to fabricate a single piece, near-net shape, structure. This process is termed 'near-net' because only a minimal amount of post-forge machining is required. The near-net forging process was developed to reduce the material scrap rate (buy-to-fly ratio) and fabrication costs associated with conventional manufacturing methods. The goal for the near-net forging process, when mature, is to achieve an overall cost reduction of approximately 50 percent compared with conventional manufacturing options for producing structures fabricated from Al-Li alloys. This NASA Marshall Space Flight Center (MSFC) sponsored program has been a part of a unique government / industry partnership, coordinated to develop and demonstrate near-net forging technology. The objective of this program was to demonstrate scale-up of the near-net forging process. This objective was successfully achieved by fabricating four integrally stiffened, 170- inch diameter by 20-inch tall, Al-Li alloy 2195, Y-ring adapters. Initially, two 2195 Al-Li ingots were converted and back extruded to produce four cylindrical blockers. Conventional ring rolling of the blockers was performed to produce ring preforms, which were then contour ring rolled to produce

  20. DOE Solar Energy Technologies Program FY 2005 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    2006-03-01

    The DOE Solar Energy Technologies Program FY 2005 Annual Report chronicles the R&D results of the U.S. Department of Energy Solar Energy Technologies Program for Fiscal Year 2005. In particular, the report describes R&D performed by the Program?s national laboratories (National Renewable Energy Laboratory, Sandia National Laboratories, Oak Ridge National Laboratory, and Brookhaven National Laboratory) and university and industry partners.

  1. Epigenetics and developmental programming of welfare and production traits in farm animals.

    Science.gov (United States)

    Sinclair, K D; Rutherford, K M D; Wallace, J M; Brameld, J M; Stöger, R; Alberio, R; Sweetman, D; Gardner, D S; Perry, V E A; Adam, C L; Ashworth, C J; Robinson, J E; Dwyer, C M

    2016-07-21

    The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

  2. 2013 Building Technologies Office Program Peer Review Report

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-11-01

    The 2013 Building Technologies Office Program Peer Review Report summarizes the results of the 2013 Building Technologies Office (BTO) peer review, which was held in Washington, D.C., on April 2–4, 2013. The review was attended by over 300 participants and included presentations on 59 BTO-funded projects: 29 from BTO’s Emerging Technologies Program, 20 from the Commercial Buildings Integration Program, 6 from the Residential Buildings Integration Program, and 4 from the Building Energy Codes Program. This report summarizes the scores and comments provided by the independent reviewers for each project.

  3. NASA technology utilization program: The small business market

    Science.gov (United States)

    Vannoy, J. K.; Garcia-Otero, F.; Johnson, F. D.; Staskin, E.

    1980-01-01

    Technology transfer programs were studied to determine how they might be more useful to the small business community. The status, needs, and technology use patterns of small firms are reported. Small business problems and failures are considered. Innovation, capitalization, R and D, and market share problems are discussed. Pocket, captive, and new markets are summarized. Small manufacturers and technology acquisition are discussed, covering external and internal sources, and NASA technology. Small business and the technology utilization program are discussed, covering publications and industrial applications centers. Observations and recommendations include small business market development and contracting, and NASA management technology.

  4. Variable Cycle Engine Technology Program Planning and Definition Study

    Science.gov (United States)

    Westmoreland, J. S.; Stern, A. M.

    1978-01-01

    The variable stream control engine, VSCE-502B, was selected as the base engine, with the inverted flow engine concept selected as a backup. Critical component technologies were identified, and technology programs were formulated. Several engine configurations were defined on a preliminary basis to serve as demonstration vehicles for the various technologies. The different configurations present compromises in cost, technical risk, and technology return. Plans for possible variably cycle engine technology programs were formulated by synthesizing the technology requirements with the different demonstrator configurations.

  5. Sleep Problems and Early Developmental Delay: Implications for Early Intervention Programs

    Science.gov (United States)

    Bonuck, Karen; Grant, Roy

    2012-01-01

    Sleep disorders negatively impact behavior, cognition, and growth--the same areas targeted by early intervention. Conversely, developmental delays and disabilities may themselves precipitate sleep disorders. Young children with developmental delays experience sleep disorders at a higher rate than do typically developing children; the most common…

  6. The Quick Peek Program: A Model for Developmental Screening within Underserved Communities

    Science.gov (United States)

    Harris, Jill; Norton, Amy

    2016-01-01

    Developmental screening of young children is important in all populations, especially underserved communities with known health care disparities. The American Academy of Pediatrics created guidelines and a toolkit for pediatricians to conduct developmental surveillance and screening, yet these guidelines are not uniformly implemented within…

  7. The evolution of developmental programs : a case study in the gastropod mollusc Patella vulgata

    NARCIS (Netherlands)

    Nederbragt, Alexander Johan

    2002-01-01

    At the interface between evolutionary biology and developmental biology is the so-called field of evolutionary developmental biology (‘evo-devo’ in short). This field asks how different adult animals (species) came into being by heritable changes during their embryonic development. One way to study

  8. Developmental Programming in Response to Intrauterine Growth Restriction Impairs Myoblast Function and Skeletal Muscle Metabolism

    Science.gov (United States)

    Yates, D. T.; Macko, A. R.; Nearing, M.; Chen, X.; Rhoads, R. P.; Limesand, S. W.

    2012-01-01

    Fetal adaptations to placental insufficiency alter postnatal metabolic homeostasis in skeletal muscle by reducing glucose oxidation rates, impairing insulin action, and lowering the proportion of oxidative fibers. In animal models of intrauterine growth restriction (IUGR), skeletal muscle fibers have less myonuclei at birth. This means that myoblasts, the sole source for myonuclei accumulation in fibers, are compromised. Fetal hypoglycemia and hypoxemia are complications that result from placental insufficiency. Hypoxemia elevates circulating catecholamines, and chronic hypercatecholaminemia has been shown to reduce fetal muscle development and growth. We have found evidence for adaptations in adrenergic receptor expression profiles in myoblasts and skeletal muscle of IUGR sheep fetuses with placental insufficiency. The relationship of β-adrenergic receptors shifts in IUGR fetuses because Adrβ2 expression levels decline and Adrβ1 expression levels are unaffected in myofibers and increased in myoblasts. This adaptive response would suppress insulin signaling, myoblast incorporation, fiber hypertrophy, and glucose oxidation. Furthermore, this β-adrenergic receptor expression profile persists for at least the first month in IUGR lambs and lowers their fatty acid mobilization. Developmental programming of skeletal muscle adrenergic receptors partially explains metabolic and endocrine differences in IUGR offspring, and the impact on metabolism may result in differential nutrient utilization. PMID:22900186

  9. Developmental Programming in Response to Intrauterine Growth Restriction Impairs Myoblast Function and Skeletal Muscle Metabolism

    Directory of Open Access Journals (Sweden)

    D. T. Yates

    2012-01-01

    Full Text Available Fetal adaptations to placental insufficiency alter postnatal metabolic homeostasis in skeletal muscle by reducing glucose oxidation rates, impairing insulin action, and lowering the proportion of oxidative fibers. In animal models of intrauterine growth restriction (IUGR, skeletal muscle fibers have less myonuclei at birth. This means that myoblasts, the sole source for myonuclei accumulation in fibers, are compromised. Fetal hypoglycemia and hypoxemia are complications that result from placental insufficiency. Hypoxemia elevates circulating catecholamines, and chronic hypercatecholaminemia has been shown to reduce fetal muscle development and growth. We have found evidence for adaptations in adrenergic receptor expression profiles in myoblasts and skeletal muscle of IUGR sheep fetuses with placental insufficiency. The relationship of β-adrenergic receptors shifts in IUGR fetuses because Adrβ2 expression levels decline and Adrβ1 expression levels are unaffected in myofibers and increased in myoblasts. This adaptive response would suppress insulin signaling, myoblast incorporation, fiber hypertrophy, and glucose oxidation. Furthermore, this β-adrenergic receptor expression profile persists for at least the first month in IUGR lambs and lowers their fatty acid mobilization. Developmental programming of skeletal muscle adrenergic receptors partially explains metabolic and endocrine differences in IUGR offspring, and the impact on metabolism may result in differential nutrient utilization.

  10. Asymmetric division and differential gene expression during a bacterial developmental program requires DivIVA.

    Directory of Open Access Journals (Sweden)

    Prahathees Eswaramoorthy

    2014-08-01

    Full Text Available Sporulation in the bacterium Bacillus subtilis is a developmental program in which a progenitor cell differentiates into two different cell types, the smaller of which eventually becomes a dormant cell called a spore. The process begins with an asymmetric cell division event, followed by the activation of a transcription factor, σF, specifically in the smaller cell. Here, we show that the structural protein DivIVA localizes to the polar septum during sporulation and is required for asymmetric division and the compartment-specific activation of σF. Both events are known to require a protein called SpoIIE, which also localizes to the polar septum. We show that DivIVA copurifies with SpoIIE and that DivIVA may anchor SpoIIE briefly to the assembling polar septum before SpoIIE is subsequently released into the forespore membrane and recaptured at the polar septum. Finally, using super-resolution microscopy, we demonstrate that DivIVA and SpoIIE ultimately display a biased localization on the side of the polar septum that faces the smaller compartment in which σF is activated.

  11. Developmental programming: interaction between prenatal BPA exposure and postnatal adiposity on metabolic variables in female sheep.

    Science.gov (United States)

    Veiga-Lopez, Almudena; Moeller, Jacob; Sreedharan, Rohit; Singer, Kanakadurga; Lumeng, Carey; Ye, Wen; Pease, Anthony; Padmanabhan, Vasantha

    2016-02-01

    Among potential contributors for the increased incidence of metabolic diseases is the developmental exposure to endocrine-disrupting chemicals such as bisphenol A (BPA). BPA is an estrogenic chemical used in a variety of consumer products. Evidence points to interactions of BPA with the prevailing environment. The aim of this study was to assess the effects of prenatal exposure to BPA on postnatal metabolic outcomes, including insulin resistance, adipose tissue distribution, adipocyte morphometry, and expression of inflammatory markers in adipose tissue as well as to assess whether postnatal overfeeding would exacerbate these effects. Findings indicate that prenatal BPA exposure leads to insulin resistance in adulthood in the first breeder cohort (study 1), but not in the second cohort (study 2), which is suggestive of potential differences in genetic susceptibility. BPA exposure induced adipocyte hypertrophy in the visceral fat depot without an accompanying increase in visceral fat mass or increased CD68, a marker of macrophage infiltration, in the subcutaneous fat depot. Cohens effect size analysis found the ratio of visceral to subcutaneous fat depot in the prenatal BPA-treated overfed group to be higher compared with the control-overfed group. Altogether, these results suggest that exposure to BPA during fetal life at levels found in humans can program metabolic outcomes that lead to insulin resistance, a forerunner of type 2 diabetes, with postnatal obesity failing to manifest any interaction with prenatal BPA relative to insulin resistance and adipocyte hypertrophy. Copyright © 2016 the American Physiological Society.

  12. Global Developmental Gene Programing Involves a Nuclear Form of Fibroblast Growth Factor Receptor-1 (FGFR1.

    Directory of Open Access Journals (Sweden)

    Christopher Terranova

    Full Text Available Genetic studies have placed the Fgfr1 gene at the top of major ontogenic pathways that enable gastrulation, tissue development and organogenesis. Using genome-wide sequencing and loss and gain of function experiments the present investigation reveals a mechanism that underlies global and direct gene regulation by the nuclear form of FGFR1, ensuring that pluripotent Embryonic Stem Cells differentiate into Neuronal Cells in response to Retinoic Acid. Nuclear FGFR1, both alone and with its partner nuclear receptors RXR and Nur77, targets thousands of active genes and controls the expression of pluripotency, homeobox, neuronal and mesodermal genes. Nuclear FGFR1 targets genes in developmental pathways represented by Wnt/β-catenin, CREB, BMP, the cell cycle and cancer-related TP53 pathway, neuroectodermal and mesodermal programing networks, axonal growth and synaptic plasticity pathways. Nuclear FGFR1 targets the consensus sequences of transcription factors known to engage CREB-binding protein, a common coregulator of transcription and established binding partner of nuclear FGFR1. This investigation reveals the role of nuclear FGFR1 as a global genomic programmer of cell, neural and muscle development.

  13. Robotics Technology Development Program Cross Cutting and Advanced Technology

    International Nuclear Information System (INIS)

    Harrigan, R.W.; Horschel, D.S.

    1994-01-01

    Need-based cross cutting technology is being developed which is broadly applicable to the clean up of hazardous and radioactive waste within the US Department of Energy's complex. Highly modular, reusable technologies which plug into integrated system architectures to meet specific robotic needs result from this research. In addition, advanced technologies which significantly extend current capabilities such as automated planning and sensor-based control in unstructured environments for remote system operation are also being developed and rapidly integrated into operating systems

  14. A Technological Teacher Education Program Planning Model.

    Science.gov (United States)

    Hansen, Ronald E.

    1993-01-01

    A model for technology teacher education curriculum has three facets: (1) purpose (experiential learning, personal development, technological enlightenment, economic well-being); (2) content (professional knowledge, curriculum development competence, pedagogical knowledge and skill, technological foundations); and (3) process (planned reflection,…

  15. Teaching Machines, Programming, Computers, and Instructional Technology: The Roots of Performance Technology.

    Science.gov (United States)

    Deutsch, William

    1992-01-01

    Reviews the history of the development of the field of performance technology. Highlights include early teaching machines, instructional technology, learning theory, programed instruction, the systems approach, needs assessment, branching versus linear program formats, programing languages, and computer-assisted instruction. (LRW)

  16. Shippingport station decommissioning project technology transfer program

    International Nuclear Information System (INIS)

    McKernan, M.L.

    1989-01-01

    The US Department of Energy (DOE) Shippingport Station Decommissioning Project (SSDP) decontaminated and dismantled the world's first nuclear-fueled, commercial-size electric power plant. The SSDP programmatic goal direction for technology transfer is documentation of project management and operations experience. The objective is to provide future nuclear facility decommissioning projects with pertinent SSDP performance data for project assessment, planning, and operational implementation. This paper sets out access and availability directions for SSDP technology acquisition. Discusses are technology transfer definition; technology transfer products including topical and other project reports, professional-technical society presentations, other project liaison and media relations, visual documentation, and technology transfer data base; and retrieving SSDP information

  17. National Survey of Computer Aided Manufacturing in Industrial Technology Programs.

    Science.gov (United States)

    Heidari, Farzin

    The current status of computer-aided manufacturing in the 4-year industrial technology programs in the United States was studied. All industrial technology department chairs were mailed a questionnaire divided into program information, equipment information, and general comments sections. The questionnaire was designed to determine the subjects…

  18. AECL's research and development program in environmental science and technology

    International Nuclear Information System (INIS)

    Cornett, R.J.

    1998-07-01

    AECL's radiological research and development (R and D) program encompasses work on sources of radiation exposure, radionuclide transport through the environment and potential impacts on biota and on human health. The application of the radiation protection knowledge and technology developed in this program provides cradle-to-grave management for CANDU and related nuclear technologies. This document provides an overview of the Environmental Science and Technology (ES and T) program which is one of the technical areas of R and D within the radiological R and D program. The ES and T program uses science from three main areas: radiochemistry, mathematical modelling and environmental assessment. In addition to providing an overview of the program, this summary also gives specific examples of recent technical work in each of the three areas. These technical examples illustrate the applied nature of the ES and T program and the close coupling of the program to CANDU customer requirements. (author)

  19. Hydrogen, Fuel Cells & Infrastructure Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    2005-03-01

    This plan details the goals, objectives, technical targets, tasks and schedule for EERE's contribution to the DOE Hydrogen Program. Similar detailed plans exist for the other DOE offices that make up the Hydrogen Program.

  20. MLS student active learning within a "cloud" technology program.

    Science.gov (United States)

    Tille, Patricia M; Hall, Heather

    2011-01-01

    In November 2009, the MLS program in a large public university serving a geographically large, sparsely populated state instituted an initiative for the integration of technology enhanced teaching and learning within the curriculum. This paper is intended to provide an introduction to the system requirements and sample instructional exercises used to create an active learning technology-based classroom. Discussion includes the following: 1.) define active learning and the essential components, 2.) summarize teaching methods, technology and exercises utilized within a "cloud" technology program, 3.) describe a "cloud" enhanced classroom and programming 4.) identify active learning tools and exercises that can be implemented into laboratory science programs, and 5.) describe the evaluation and assessment of curriculum changes and student outcomes. The integration of technology in the MLS program is a continual process and is intended to provide student-driven active learning experiences.

  1. Part 2 -- current program integrating strategies and lubrication technology

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, B.

    1996-12-01

    This paper is the second of two that describe the Predictive Maintenance Program for rotating machinery at the Palo Verde Nuclear Generating Station. The Predictive Maintenance program has been enhanced through organizational changes and improved interdisciplinary usage of technology. This paper will discuss current program strategies that have improved the interaction between the Vibration and Lube Oil programs. The {open_quotes}Lube Oil{close_quotes} view of the combined program along with case studies will then be presented.

  2. Part 2 -- current program integrating strategies and lubrication technology

    International Nuclear Information System (INIS)

    Johnson, B.

    1996-01-01

    This paper is the second of two that describe the Predictive Maintenance Program for rotating machinery at the Palo Verde Nuclear Generating Station. The Predictive Maintenance program has been enhanced through organizational changes and improved interdisciplinary usage of technology. This paper will discuss current program strategies that have improved the interaction between the Vibration and Lube Oil programs. The open-quotes Lube Oilclose quotes view of the combined program along with case studies will then be presented

  3. United States Superconducting MHD Magnet Technology Development Program

    International Nuclear Information System (INIS)

    Dawson, A.M.; Marston, P.G.; Thome, R.J.; Iwasa, Y.; Tarrh, J.M.

    1981-01-01

    A three-faceted program supported by the U.S. Dep of Energy is described. These facets include basic technology development, technology transfer and construction by industry of magnets for the national MHD program. The program includes the maintenance of a large component test facility; investigation of superconductor stability and structural behavior; measurements of materials' properties at low temperatures; structural design optimization; analytical code development; cryogenic systems and power supply design. The technology transfer program is designed to bring results of technology development and design and construction effort to the entire superconducting magnet community. The magnet procurement program is responsible for developing conceptual designs of magnets needed for the national MHD program, for issuing requests for quotation, selecting vendors and supervising design, construction, installation and test of these systems. 9 refs

  4. U.S. ENVIRONMENTAL PROTECTION AGENCY (EPA) ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM: ARSENIC TREATMENT TECHNOLOGIES

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This techn...

  5. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-08-01

    This report identifies the commercial and near-commercial (emerging) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies Program in the Office of Energy Efficiency and Renewable Energy.

  6. Shippingport station decommissioning project technology transfer program

    International Nuclear Information System (INIS)

    McKernan, M.L.

    1988-01-01

    US Department of Energy (DOE) Shippingport Station Decommissioning Project (SSDP) decommissioned, decontaminated, and dismantled the world's first, nuclear fueled, commercial size, electric power plant. SSDP programmatic goal direction for technology transfer is documentation of project management and operations experience. Objective is to provide future nuclear facility decommissioning projects with pertinent SSDP performance data for project assessment, planning, and operational implementation. This paper presents a working definition for technology transfer. Direction is provided for access and availability for SSDP technology acquisition

  7. 48 CFR 235.006-70 - Manufacturing Technology Program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Manufacturing Technology... CONTRACTING 235.006-70 Manufacturing Technology Program. In accordance with 10 U.S.C. 2521(d), for acquisitions under the Manufacturing Technology Program— (a) Award all contracts using competitive procedures...

  8. Computing, Information, and Communications Technology (CICT) Program Overview

    Science.gov (United States)

    VanDalsem, William R.

    2003-01-01

    The Computing, Information and Communications Technology (CICT) Program's goal is to enable NASA's Scientific Research, Space Exploration, and Aerospace Technology Missions with greater mission assurance, for less cost, with increased science return through the development and use of advanced computing, information and communication technologies

  9. 76 FR 70970 - Technology Innovation Program Advisory Board

    Science.gov (United States)

    2011-11-16

    ... Technology, Education, and Science (COMPETES) Act, Public Law 110-69 (August 9, 2007), 15 U.S.C. 278n, the... eminent in such fields as business, research, science and technology, engineering, education, and... Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce...

  10. General program for the advancement of the radionuclide technology

    International Nuclear Information System (INIS)

    1979-12-01

    The 'General Program for the Advancement of the Radionuclide Technology' was elaborated in 1978 by the 'Arbeitsgemeinschaft zur Foerderung der Radionuklidtechnik' (AFR) (Association for the Promotion of Radionuclide Technology). In addition to an inventory of the major applications of radionuclide technology, this General Program includes a comprehensive description of tasks relating to the central topics of raw materials, environment, technology and materials, health and nutrition, scientific developments of radionuclide technology. The 'General Program for the Advancement of the Radionuclide Technology' serves inter alia as a basis of evaluation in opinions on funding applications filed with the Federal Ministry for Research and Technology (BMFT) with respect to the provision of advanced techniques involving radionuclides for industrial application. (orig.) [de

  11. In-Space Propulsion Technology Program Solar Electric Propulsion Technologies

    Science.gov (United States)

    Dankanich, John W.

    2006-01-01

    NASA's In-space Propulsion (ISP) Technology Project is developing new propulsion technologies that can enable or enhance near and mid-term NASA science missions. The Solar Electric Propulsion (SEP) technology area has been investing in NASA s Evolutionary Xenon Thruster (NEXT), the High Voltage Hall Accelerator (HiVHAC), lightweight reliable feed systems, wear testing, and thruster modeling. These investments are specifically targeted to increase planetary science payload capability, expand the envelope of planetary science destinations, and significantly reduce the travel times, risk, and cost of NASA planetary science missions. Status and expected capabilities of the SEP technologies are reviewed in this presentation. The SEP technology area supports numerous mission studies and architecture analyses to determine which investments will give the greatest benefit to science missions. Both the NEXT and HiVHAC thrusters have modified their nominal throttle tables to better utilize diminished solar array power on outbound missions. A new life extension mechanism has been implemented on HiVHAC to increase the throughput capability on low-power systems to meet the needs of cost-capped missions. Lower complexity, more reliable feed system components common to all electric propulsion (EP) systems are being developed. ISP has also leveraged commercial investments to further validate new ion and hall thruster technologies and to potentially lower EP mission costs.

  12. DOE Solar Energy Technologies Program: FY 2004 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    2005-10-01

    The DOE Solar Energy Technologies Program FY 2004 Annual Report chronicles the R&D results of the U.S. Department of Energy Solar Energy Technologies Program for Fiscal Year 2004. In particular, the report describes R&D performed by the Program's national laboratories (National Renewable Energy Laboratory, Sandia National Laboratories, Oak Ridge National Laboratory, and Brookhaven National Laboratory) and university and industry partners.

  13. DOE Solar Energy Technologies Program FY 2006 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    2007-07-01

    The DOE Solar Energy Technologies Program FY 2006 Annual Report chronicles the R&D results of the U.S. Department of Energy Solar Energy Technologies Program for Fiscal Year 2005. In particular, the report describes R&D performed by the Program's national laboratories (National Renewable Energy Laboratory, Sandia National Laboratories, Oak Ridge National Laboratory, and Brookhaven National Laboratory) and university and industry partners.

  14. DOE Solar Energy Technologies Program 2007 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    2008-07-01

    The DOE Solar Energy Technologies Program FY 2007 Annual Report chronicles the R&D results of the U.S. Department of Energy Solar Energy Technologies Program from October 2006 to September 2007. In particular, the report describes R&D performed by the Program's national laboratories (National Renewable Energy Laboratory, Sandia National Laboratories, Oak Ridge National Laboratory, and Brookhaven National Laboratory) and university and industry partners.

  15. Integrating Technology into the Developmental Mathematics Classroom: A WebQuest

    Science.gov (United States)

    Salsovic, Annette

    2007-01-01

    Although the WebQuest has been around for several years, it appears that not many educators are aware of it, or know how to use it. Thus, it is important to not only expose developmental educators to the use of this strategy, but also to help them realize how they can easily implement it into their curriculum. The use of a Webquest integrates…

  16. Do Developmental Mathematics Programs Have a Causal Impact on Student Retention? An Application of Discrete-Time Survival and Regression-Discontinuity Analysis

    Science.gov (United States)

    Lesik, Sally A.

    2007-01-01

    The impact of academic programs--such as developmental mathematics programs--on student retention, has been a controversial topic for administrators, policy makers, and faculty in higher education. Despite deep interest in the effectiveness of these programs in retaining students, scholars have been unable to determine whether such programs have a…

  17. Highly precise and developmentally programmed genome assembly in Paramecium requires ligase IV-dependent end joining.

    Directory of Open Access Journals (Sweden)

    Aurélie Kapusta

    2011-04-01

    Full Text Available During the sexual cycle of the ciliate Paramecium, assembly of the somatic genome includes the precise excision of tens of thousands of short, non-coding germline sequences (Internal Eliminated Sequences or IESs, each one flanked by two TA dinucleotides. It has been reported previously that these genome rearrangements are initiated by the introduction of developmentally programmed DNA double-strand breaks (DSBs, which depend on the domesticated transposase PiggyMac. These DSBs all exhibit a characteristic geometry, with 4-base 5' overhangs centered on the conserved TA, and may readily align and undergo ligation with minimal processing. However, the molecular steps and actors involved in the final and precise assembly of somatic genes have remained unknown. We demonstrate here that Ligase IV and Xrcc4p, core components of the non-homologous end-joining pathway (NHEJ, are required both for the repair of IES excision sites and for the circularization of excised IESs. The transcription of LIG4 and XRCC4 is induced early during the sexual cycle and a Lig4p-GFP fusion protein accumulates in the developing somatic nucleus by the time IES excision takes place. RNAi-mediated silencing of either gene results in the persistence of free broken DNA ends, apparently protected against extensive resection. At the nucleotide level, controlled removal of the 5'-terminal nucleotide occurs normally in LIG4-silenced cells, while nucleotide addition to the 3' ends of the breaks is blocked, together with the final joining step, indicative of a coupling between NHEJ polymerase and ligase activities. Taken together, our data indicate that IES excision is a "cut-and-close" mechanism, which involves the introduction of initiating double-strand cleavages at both ends of each IES, followed by DSB repair via highly precise end joining. This work broadens our current view on how the cellular NHEJ pathway has cooperated with domesticated transposases for the emergence of new

  18. Highly precise and developmentally programmed genome assembly in Paramecium requires ligase IV-dependent end joining.

    Science.gov (United States)

    Kapusta, Aurélie; Matsuda, Atsushi; Marmignon, Antoine; Ku, Michael; Silve, Aude; Meyer, Eric; Forney, James D; Malinsky, Sophie; Bétermier, Mireille

    2011-04-01

    During the sexual cycle of the ciliate Paramecium, assembly of the somatic genome includes the precise excision of tens of thousands of short, non-coding germline sequences (Internal Eliminated Sequences or IESs), each one flanked by two TA dinucleotides. It has been reported previously that these genome rearrangements are initiated by the introduction of developmentally programmed DNA double-strand breaks (DSBs), which depend on the domesticated transposase PiggyMac. These DSBs all exhibit a characteristic geometry, with 4-base 5' overhangs centered on the conserved TA, and may readily align and undergo ligation with minimal processing. However, the molecular steps and actors involved in the final and precise assembly of somatic genes have remained unknown. We demonstrate here that Ligase IV and Xrcc4p, core components of the non-homologous end-joining pathway (NHEJ), are required both for the repair of IES excision sites and for the circularization of excised IESs. The transcription of LIG4 and XRCC4 is induced early during the sexual cycle and a Lig4p-GFP fusion protein accumulates in the developing somatic nucleus by the time IES excision takes place. RNAi-mediated silencing of either gene results in the persistence of free broken DNA ends, apparently protected against extensive resection. At the nucleotide level, controlled removal of the 5'-terminal nucleotide occurs normally in LIG4-silenced cells, while nucleotide addition to the 3' ends of the breaks is blocked, together with the final joining step, indicative of a coupling between NHEJ polymerase and ligase activities. Taken together, our data indicate that IES excision is a "cut-and-close" mechanism, which involves the introduction of initiating double-strand cleavages at both ends of each IES, followed by DSB repair via highly precise end joining. This work broadens our current view on how the cellular NHEJ pathway has cooperated with domesticated transposases for the emergence of new mechanisms

  19. Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis.

    Science.gov (United States)

    Occhetta, Paola; Pigeot, Sebastien; Rasponi, Marco; Dasen, Boris; Mehrkens, Arne; Ullrich, Thomas; Kramer, Ina; Guth-Gundel, Sabine; Barbero, Andrea; Martin, Ivan

    2018-05-01

    It is generally accepted that adult human bone marrow-derived mesenchymal stromal cells (hMSCs) are default committed toward osteogenesis. Even when induced to chondrogenesis, hMSCs typically form hypertrophic cartilage that undergoes endochondral ossification. Because embryonic mesenchyme is obviously competent to generate phenotypically stable cartilage, it is questioned whether there is a correspondence between mesenchymal progenitor compartments during development and in adulthood. Here we tested whether forcing specific early events of articular cartilage development can program hMSC fate toward stable chondrogenesis. Inspired by recent findings that spatial restriction of bone morphogenetic protein (BMP) signaling guides embryonic progenitors toward articular cartilage formation, we hypothesized that selective inhibition of BMP drives the phenotypic stability of hMSC-derived chondrocytes. Two BMP type I receptor-biased kinase inhibitors were screened in a microfluidic platform for their time- and dose-dependent effect on hMSC chondrogenesis. The different receptor selectivity profile of tested compounds allowed demonstration that transient blockade of both ALK2 and ALK3 receptors, while permissive to hMSC cartilage formation, is necessary and sufficient to maintain a stable chondrocyte phenotype. Remarkably, even upon compound removal, hMSCs were no longer competent to undergo hypertrophy in vitro and endochondral ossification in vivo, indicating the onset of a constitutive change. Our findings demonstrate that adult hMSCs effectively share properties of embryonic mesenchyme in the formation of transient but also of stable cartilage. This opens potential pharmacological strategies to articular cartilage regeneration and more broadly indicates the relevance of developmentally inspired protocols to control the fate of adult progenitor cell systems.

  20. A Contemporary Preservice Technology Education Program

    Science.gov (United States)

    Flanigan, Rod; Becker, Kurt; Stewardson, Gary

    2012-01-01

    In order to teach engineering education, today's engineering and technology education teachers must be equipped with lesson plans to teach engineering design, among other principles, to the 6th-12th grade levels. At Utah State University (USU), curriculum has been developed for preservice engineering and technology education teachers that…

  1. Remote sensing education in NASA's technology transfer program

    Science.gov (United States)

    Weinstein, R. H.

    1981-01-01

    Remote sensing is a principal focus of NASA's technology transfer program activity with major attention to remote sensing education the Regional Program and the University Applications Program. Relevant activities over the past five years are reviewed and perspective on future directions is presented.

  2. CLINICAL AND PHARMACOECONOMIC REASONABILITY OF USING PROBIOTIC ENTEROCOCCUS STRAIN FOR THE COMPLEX DEVELOPMENTAL CARE PROGRAM FOR PREMATURE INFANTS

    Directory of Open Access Journals (Sweden)

    N. V. Gonchar

    2015-01-01

    Full Text Available Introduction. Possibilities of using probiotic enterococci in premature neonates undergoing inpatient antibacterial therapy remains understudied. The article is aimed at analyzing clinical and pharmacoeconomic reasonability of using probiotic Enterococcus faecium L3 strain in premature infants with very low body weight in the framework of complex inpatient developmental care. Patients and methods. 55 children randomized into 2 groups were observed: the control group (n = 26 was undergoing standard developmental care program, the primary group (n = 29 was introduced liquid probiotic Enterococcus faecium L3 strain (titer — 108 CFU/ml or more (0.5 ml TID for 14 days after attaining the enteral feeding volume of 5.0 ml. Results. Analysis of the clinical symptoms characteristic of non-smooth course of developmental care over premature infants helped to reveal higher frequency of infectious complications in the control group children than in the primary group (14 [53.8%] vs. 6 [20.7%]; p < 0.05. Acute food intolerance was observed less frequently in the primary group than in the control group (6 [20.7%] vs. 10 [38.5%], p > 0.05. The primary group's children featured significant decrease in the frequency of monocytosis, positive changes of intestinal microbiotic composition (increase in the amount of bifidum bacteria, lactobacilli, enterococci, decrease in the amount of Clostridium difficile and antibiotic-resistant clinical Klebsiella pneumoniae strains. Conclusion. Favorable outcome of developmental care over premature infants (absence of infectious complications was less expensive in the primary group's children.

  3. Two Inseparable Facets of Technology Integration Programs: Technology and Theoretical Framework

    Science.gov (United States)

    Demir, Servet

    2011-01-01

    This paper considers the process of program development aiming at technology integration for teachers. For this consideration, the paper focused on an integration program which was recently developed as part of a larger project. The participants of this program were 45 in-service teachers. The program continued four weeks and the conduct of the…

  4. Prenatal ethanol exposure-induced adrenal developmental abnormality of male offspring rats and its possible intrauterine programming mechanisms.

    Science.gov (United States)

    Huang, Hegui; He, Zheng; Zhu, Chunyan; Liu, Lian; Kou, Hao; Shen, Lang; Wang, Hui

    2015-10-01

    Fetal adrenal developmental status is the major determinant of fetal tissue maturation and offspring growth. We have previously proposed that prenatal ethanol exposure (PEE) suppresses fetal adrenal corticosterone (CORT) synthesis. Here, we focused on PEE-induced adrenal developmental abnormalities of male offspring rats before and after birth, and aimed to explore its intrauterine programming mechanisms. A rat model of intrauterine growth retardation (IUGR) was established by PEE (4g/kg·d). In PEE fetus, increased serum CORT concentration and decreased insulin-like growth factor 1 (IGF1) concentration, with lower bodyweight and structural abnormalities as well as a decreased Ki67 expression (proliferative marker), were observed in the male fetal adrenal cortex. Adrenal glucocorticoid (GC)-metabolic activation system was enhanced while gene expression of IGF1 signaling pathway with steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase (3β-HSD) was decreased. Furthermore, in the male adult offspring of PEE, serum CORT level was decreased but IGF1 was increased with partial catch-up growth, and Ki67 expression demonstrated no obvious change. Adrenal GC-metabolic activation system was inhibited, while IGF1 signaling pathway and 3β-HSD was enhanced with the steroidogenic factor 1 (SF1), and StAR was down-regulated in the adult adrenal. Based on these findings, we propose a "two-programming" mechanism for PEE-induced adrenal developmental toxicity: "the first programming" is a lower functional programming of adrenal steroidogenesis, and "the second programming" is GC-metabolic activation system-related GC-IGF1 axis programming. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. ONR D&I Electronics Technology Programs

    National Research Council Canada - National Science Library

    Moon, Jeong

    2008-01-01

    Program Status: One of the D&I program goals is to develop greatly improved field-plated MMW GaN HEMT devices with high ft/fmax, which will improve gain/PAE and output power of GaN HEMT MMIC PAs simultaneously...

  6. [The effect of parent training program on children with attention deficit/hyperactivity disorders and/or pervasive developmental disorders].

    Science.gov (United States)

    Motoyama, Kazunori; Matsuzaka, Tetsuo; Nagaoka, Tamao; Matsuo, Mitsuhiro

    2012-07-01

    Mothers of 18 children with attention deficit/hyperactivity disorders (AD/HD) and 6 with pervasive developmental disorders (PDD) underwent a parent training (PT) program. After the program, the Beck Depression Inventory- II (BDI - II) score, which indicates parenting stress, significantly decreased from 15 to 8 (p=0.036). A total of 22 mothers had increased parenting self-esteem, and better parent-child relationships were noted in these cases. An analysis of children's behavior by using Achenbach's Child Behavior Checklist showed that introversion tendency, physical failure, aggressive behavior, and extroversion score improved significantly after PT (pparenting skills of mothers and adaptive behaviors of children.

  7. Native American Training Program in Petroleum Technology

    Energy Technology Data Exchange (ETDEWEB)

    Ho, Winifred M.; Kokesh, Judith H.

    1999-04-27

    This report outlines a comprehensive training program for members of Native American tribes whose lands have oil and gas resources. The program has two components: short courses and internships. Programs are proposed for: (1) adult tribes representatives who are responsible for managing tribal mineral holdings, setting policy, or who work in the oil and gas industry; (2) graduate and undergraduate college students who are tribal members and are studying in the appropriate fields; and (3) high school and middle school teachers, science teachers. Materials and program models already have been developed for some components of the projects. The plan is a coordinated, comprehensive effort to use existing resources to accomplish its goals. Partnerships will be established with the tribes, the BIA, tribal organizations, other government agencies, and the private sector to implement the program.

  8. The DOE safeguards and security technology development program

    International Nuclear Information System (INIS)

    Cherry, R.C.; Wheelock, A.J.

    1991-01-01

    This paper reports that strategic planning for safeguards and security within the Department of Energy emphasizes the contributions of advanced technologies to the achievement of Departmental protection program goals. The Safeguards and Security Technology Development Program provides state-of-the-art technologies, systems and technical services in support of the policies and programmatic requirements for the protection of Departmental assets. The Program encompasses research and development in physical security, nuclear material control and accountability, information security and personnel security, and the integration of these disciplines in advanced applications. Technology development tasks serve goals that range from the maintenance of an effective technology base to the development, testing and evaluation of applications to meet field needs. A variety of factors, from the evolving threat to reconfiguration of the DOE complex and the technical requirements of new facilities, are expected to influence safeguards and security technology requirements and development efforts. Implementation of the Program is based on the systematic identification, prioritization and alignment of technology development tasks and needs. Initiatives currently underway are aimed at enhancing technology development project management. Increased management attention is also being placed on efforts to promote the benefits of the Program through technology transfer and interagency liaison

  9. DOE/EPA sludge irradiation technology transfer program

    International Nuclear Information System (INIS)

    Ahlstrom, S.B.

    1980-01-01

    The cesium-137 sludge irradiation program has successfully progressed through the phases of technology development and pilot plant evaluation and has entered the technology transfer phase. Initial technology transfer activities have identified a growing interest among wastewater engineers and public officials to learn more about the application of irradiation in sludge treatment. As a result, a formal technology transfer program has been developed. As a major activity of this program, it is planned that the US Department of Energy, working with the US Environmental Protection Agency, state and local governments, will support the placement of five to 10 sludge irradiators at selected wastewater treatment facilities throughout the United States. Facilities which may best benefit from this process technology are being identified. Technology transfer will be stimulated as engineers and wastewater officials become familiar with the evaluation and implementation of sludge irradiation at these sites

  10. International technology identification, transfer, and program support

    International Nuclear Information System (INIS)

    Kitchen, B.

    1993-01-01

    Savannah River Site (SRS) activities primarily address vitrification technologies being investigated with Japan and the former Soviet Union (FSU). They also support the overall management of EM's international activities

  11. CRS&SI Technology Application Program.

    Science.gov (United States)

    2012-07-01

    This project report presents details of research carried out by the George Mason University : Consortium under a research contract from the U.S. Department of Transportations Research : and Innovative Technology Administration (RITA), in support o...

  12. Program Integration for International Technology Exchange

    International Nuclear Information System (INIS)

    Rea, J.L.

    1993-01-01

    Sandia National Laboratories (SNL), Albuquerque, New Mexico, supports the International Technology Exchange Division (ITED) through the integration of all international activities conducted within the DOE's Office of Environmental Management (EM)

  13. HTGR generic technology program. Semiannual report ending March 31, 1980

    International Nuclear Information System (INIS)

    1980-05-01

    This document reports the technical accomplishments on the HTGR Generic Technology Program at General Atomic during the first half of FY-80. It covers a period when the design direction of the National HTGR Program is in the process of an overall review. The HTGR Generic Technology Program activities have continued so as to provide the basic technology required for all HTGR applications. The activities include the need to develop an MEU fuel and the need to qualify materials and components for the higher temperatures of the gas turbine and process heat plants

  14. The TMI-2 remote technology program

    International Nuclear Information System (INIS)

    Bengel, P.R.

    1986-01-01

    Since the accident at Three Mile Island Unit 2 (TMI-2), an aggressive approach has been pursued in developing the tools needed for the recovery of the plant. The plant's owner has embarked on a systematic program to develop remote equipment. The program developed conceptual and then physical equipment. The remote reconnaissance vehicles (RRVs) and the remote working vehicle (RWV) span the requirements of the recovery program from the ability to perform radiological and video surveys to heavy-duty decontamination and demolition work. 4 figs

  15. Interior LED Lighting Technology. Navy Energy Technology Validation (Techval) Program

    Science.gov (United States)

    2015-09-01

    usually on most of the time. • Consider replacing existing CFL, high-intensity discharge (HID), or halogen lamp light fixtures/ lamps with LED fixtures... lamps . What is the Technology? An LED is a semiconductor-diode that emits light when power is applied. A driver is used, much as a ballast, to...available in integrated luminaires that can be used to replace existing luminaires. LEDs are also available as direct replacement lamps for many

  16. Mississippi Curriculum Framework for Drafting and Design Technology (Program CIP: 48.0102--Architectural Drafting Technology) (Program CIP: 48.0101--General Drafting). Postsecondary Programs.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the two course sequences of the state's postsecondary-level drafting and design technology program: architectural drafting technology and drafting and design technology. Presented first are a program description and…

  17. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2011-09-01

    This FY 2011 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  18. Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program - 2012

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-09-01

    This FY 2012 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

  19. Technological Innovation and Developmental Strategies for Sustainable Management of Aquatic Resources in Developing Countries

    Science.gov (United States)

    Agboola, Julius Ibukun

    2014-12-01

    Sustainable use and allocation of aquatic resources including water resources require implementation of ecologically appropriate technologies, efficient and relevant to local needs. Despite the numerous international agreements and provisions on transfer of technology, this has not been successfully achieved in developing countries. While reviewing some challenges to technological innovations and developments (TID), this paper analyzes five TID strategic approaches centered on grassroots technology development and provision of localized capacity for sustainable aquatic resources management. Three case studies provide examples of successful implementation of these strategies. Success requires the provision of localized capacity to manage technology through knowledge empowerment in rural communities situated within a framework of clear national priorities for technology development.

  20. High-safety and economical small molten-salt fission power stations and their developmental program

    International Nuclear Information System (INIS)

    Furukawa, K.; Mitachi, K.; Minami, K.; Kato, Y.

    1988-01-01

    The nuclear energy industry is not settled yet as one of the sound economical industries. Its establishment should obviously depend on the solution of the following problems: ''natural'' safety (depending on inherent natures), nuclear proliferation resistance - nearly non-production and effective incineration of Pu, Am and Om, universal resource, flexible power-size and excellent economy - wide applicability including Developing Countries. Therefore, some essentially new principles have to introduce in the nuclear energy system design. These are thorium utilization, fluid-fuel concepts, especially molten-fluoride technology, and separation of fissile-breeding and power-generation. This philosophy is named Thorium Molten-Salt Nuclear Energy Synergetics [THOMSNES]. Its practical development program is presented

  1. Developmental Scaffolding

    DEFF Research Database (Denmark)

    Giorgi, Franco; Bruni, Luis Emilio

    2015-01-01

    . Within the developmental hierarchy, each module yields an inter-level relationship that makes it possible for the scaffolding to mediate the production of selectable variations. Awide range of genetic, cellular and morphological mechanisms allows the scaffolding to integrate these modular variations...... to the complexity of sign recognition proper of a cellular community. In this semiotic perspective, the apparent goal directness of any developmental strategy should no longer be accounted for by a predetermined genetic program, but by the gradual definition of the relationships selected amongst the ones...

  2. Solar Energy Technologies Program Newsletter - Fourth Quarter 2009

    Energy Technology Data Exchange (ETDEWEB)

    DOE Solar Energy Technologies Program

    2009-12-31

    The Fourth Quarter 2009 edition of the Solar Energy Technologies Program newsletter summarizes the activities for the past three months, funding opportunities, highlights from the national labs, and upcoming events.

  3. DOE Solar Energy Technologies Program: Overview and Highlights

    Energy Technology Data Exchange (ETDEWEB)

    2006-05-01

    A non-technical overview of the U.S. Department of Energy's Solar Energy Technologies Program, including sections on photovoltaics (PV), concentrating solar power, and solar heating and lighting R&D.

  4. General atomics low speed Maglev technology development program (Supplemental #3)

    Science.gov (United States)

    2005-05-01

    This report details accomplishments of the Low Speed Maglev Technology Development Program, Supplemental #3. The 4 major tasks included: guideway foundation construction, fabrication and installation of 7 guideway modules, system integration and test...

  5. The General Atomics low speed urban Maglev technology development program

    Science.gov (United States)

    2003-01-01

    The overall objective of this program is to develop magnetic levitation technology that is a cost effective, reliable, : and environmentally friendly option for urban mass transportation in the United States. Maglev is a revolutionary : approach in w...

  6. The Alternate Technology Program for Aluminum Research Reactor Spent Fuel

    International Nuclear Information System (INIS)

    Barlow, M.W.

    1998-01-01

    This paper describes the program for disposition of aluminum-based RRSNF, including the requirements for road-ready dry storage and repository disposal and the criteria to be considered in selecting among the alternative technologies

  7. MUSICAL RADIO: THE TECHNOLOGY OF PROGRAMING

    Directory of Open Access Journals (Sweden)

    Bysko Maxim

    2016-12-01

    Full Text Available The author considers the musical radio broadcasting of the XX-XXI centuries from the point of view of a technical progress. He covers the period from "before tape" era and "tape" era to the modern digital media broadcasting (as example with the Digispot II broadcast automation software. However, despite the significant changes in technics, which are expressed primarily in the extensive use of a computer automation and reduction of programming staff (often up to two or three persons: a program director, a managing editor, a music editor, the principles of the linear broadcasting structure remained identical as a whole. So, the basic structural units here are the program blocks, "clocks", blocks of clock's elements (today, these elements often filled with automated rotation.

  8. Concrete Technology program for nuclear power plants

    International Nuclear Information System (INIS)

    Hassazadeh, M.; Wrangensten, L.

    2009-01-01

    The nuclear power plants in Sweden and Finland were built during the seventies/eighties and it is planned to extend their service life and increase their production capacity. The challenges are now to assess the condition of the concrete structures; to verify whether or not the structures can withstand the prescribed loads and functions; and verify if the structures can be upgraded in order to fulfil the requirements regarding load bearing and functional capacity. A research program was launched whose priority is condition assessment of the reactor containment. The research includes condition of the pre-stressing reinforcement, reinforcement bars, lining, leakage etc. The conditions are assessed both by destructive and non-destructive test methods. The addressed properties are physical, mechanical, electro-chemical and geometrical. The paper presents the organisation of the program, the co-operating partners, the research program, and the content of the on-going and planned research projects

  9. Effectiveness of a caregiver education program on providing oral care to individuals with intellectual and developmental disabilities.

    Science.gov (United States)

    Fickert, Nancy A; Ross, Diana

    2012-06-01

    Caregivers who work in community living arrangements or intermediate care facilities are responsible for the oral hygiene of individuals with intellectual and developmental disabilities. Oral hygiene training programs do not exist in many organizations, despite concerns about the oral care of this population. The purpose of this study was to determine the effectiveness of a caregiver educational program. This study used a quasi-experimental one-group pretest/posttest design with repeated measures to describe the outcomes of an educational program. Program participants demonstrated oral hygiene skills on each other while being scored by a trained observer, after which they completed an oral hygiene compliance survey. After three months, a follow-up included the same posttest, demonstration of oral hygiene skills, and repeat of the compliance survey. Paired-sample t-tests of oral hygiene knowledge showed a statistically significant improvement from pretest to posttest and from pretest to three-month posttest. Oral hygiene skills and compliance improved. Results demonstrate evidence that caregiver education improves knowledge, skill, and compliance in oral hygiene. Further studies are required to demonstrate the value of providing oral hygiene education and training for caregivers of individuals with intellectual and developmental disabilities.

  10. The role of a technology demonstration program for future reactors

    International Nuclear Information System (INIS)

    Viktorov, A.

    2011-01-01

    A comprehensive technology demonstration program is seen as an important component of the overall safety case, especially for a novel technology. The objective of such a program is defined as providing objective and auditable evidence that the technology will meet or exceed the relevant requirements. Various aspects of such a program are identified and then discussed in some details in this presentation. We will show how the need for such a program is anchored in fundamental safety principles. Attributes of the program, means of achieving its objective, roles of participants, as well as key steps are all elaborated. It will be argued that to prove a novel technology, the designer will have to combine several activities such as the use of operational experience, prototyping of the technology elements, conduct of experiments and tests under representative conditions, as well as modeling and analysis. Importance of availability of experimental facilities and qualified scientific and technical staff is emphasized. A solid technology demonstration program will facilitate and speed up regulatory evaluations of licensing applications. (author)

  11. The role of a technology demonstration program for future reactors

    Energy Technology Data Exchange (ETDEWEB)

    Viktorov, A. [Canadian Nuclear Safety Commission, Ottawa, Ontario (Canada)

    2011-07-01

    A comprehensive technology demonstration program is seen as an important component of the overall safety case, especially for a novel technology. The objective of such a program is defined as providing objective and auditable evidence that the technology will meet or exceed the relevant requirements. Various aspects of such a program are identified and then discussed in some details in this presentation. We will show how the need for such a program is anchored in fundamental safety principles. Attributes of the program, means of achieving its objective, roles of participants, as well as key steps are all elaborated. It will be argued that to prove a novel technology, the designer will have to combine several activities such as the use of operational experience, prototyping of the technology elements, conduct of experiments and tests under representative conditions, as well as modeling and analysis. Importance of availability of experimental facilities and qualified scientific and technical staff is emphasized. A solid technology demonstration program will facilitate and speed up regulatory evaluations of licensing applications. (author)

  12. 75 FR 15484 - Railroad Safety Technology Program Grant Program

    Science.gov (United States)

    2010-03-29

    ... governments for projects that have a public benefit of improved railroad safety and efficiency. The program... State and local governments for projects * * * that have a public benefit of improved safety and network... minimum 20 percent grantee cost share (cash or in-kind) match requirement. DATES: FRA will begin accepting...

  13. 78 FR 66987 - Railroad Safety Technology Program Grant Program

    Science.gov (United States)

    2013-11-07

    ... carriers, railroad suppliers, and State and local governments for projects that have a public benefit of... projects . . . that have a public benefit of improved safety and network efficiency.'' To be eligible for... million. This grant program has a maximum 80-percent Federal and minimum 20-percent grantee cost share...

  14. Developmental apraxia of speech : deficits in phonetic planning and motor programming

    NARCIS (Netherlands)

    Nijland, Lian

    2003-01-01

    The speech of children with developmental apraxia of speech (DAS) is highly unintelligible due to many nonsystematic sound substitutions and distortions. There is ongoing debate about the underlying deficit of the disorder. The ultimate goal of this thesis was to answer this question within the

  15. Technology readiness levels for the new millennium program

    Science.gov (United States)

    Moynihan, P. I.; Minning, C. P.; Stocky, J. F.

    2003-01-01

    NASA's New Millennium Program (NMP) seeks to advance space exploration by providing an in-space validating mechanism to verify the maturity of promising advanced technologies that cannot be adequately validated with Earth-based testing alone. In meeting this objective, NMP uses NASA Technology Readiness Levels (TRL) as key indicators of technology advancement and assesses development progress against this generalized metric. By providing an opportunity for in-space validation, NMP can mature a suitable advanced technology from TRL 4 (component and/or breadboard validation in laboratory environment) to a TRL 7 (system prototype demonstrated in an Earth-based space environment). Spaceflight technology comprises a myriad of categories, types, and functions, and as each individual technology emerges, a consistent interpretation of its specific state of technological advancement relative to other technologies is problematic.

  16. CENTER FOR ADVANCED SEPARATION TECHNOLOGY (CAST) PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Roe-Hoan; Hull, Christopher

    2014-09-30

    The U.S. is the largest producer of mining products in the world. In 2011, U.S. mining operations contributed a total of $232 billion to the nation’s GDP plus $138 billion in labor income. Of this the coal mining industry contributed a total of $97.5 billion to GDP plus $53 billion in labor income. Despite these contributions, the industry has not been well supported with research and development funds as compared to mining industries in other countries. To overcome this problem, the Center for Advanced Separation Technologies (CAST) was established to develop technologies that can be used by the U.S. mining industry to create new products, reduce production costs, and meet environmental regulations.

  17. Mexico's Program for Science and Technology, 1978 to 1982.

    Science.gov (United States)

    Flores, Edmundo

    1979-01-01

    Describes briefly the National Council for Science and Technology (CONACYT) of Mexico, and outlines Mexico's Program for Science and Technology which includes 2,489 projects in basic and applied sciences at a cost of $260 million from 1978 to 1982. (HM)

  18. Toys for Tots in Your Technology and Engineering Program

    Science.gov (United States)

    Berkeihiser, Mike

    2016-01-01

    Most technology and engineering (T&E) classes are elective, so teachers are always looking for ways to market programs, engage students, and remind administrators and school board members about the good things T&E teachers do with and for kids. In this article, the Unionville High School (PA) Technology and Engineering Department describes…

  19. Geothermal Today: 2003 Geothermal Technologies Program Highlights (Revised)

    Energy Technology Data Exchange (ETDEWEB)

    2004-05-01

    This outreach publication highlights milestones and accomplishments of the DOE Geothermal Technologies Program for 2003. Included in this publication are discussions of geothermal fundamentals, enhanced geothermal systems, direct-use applications, geothermal potential in Idaho, coating technology, energy conversion R&D, and the GeoPowering the West initiative.

  20. Using Technology in Reggio Emilia-Inspired Programs

    Science.gov (United States)

    Mitchell, Linda M.

    2007-01-01

    All young children need to interact with their environments to achieve maximum development and learning. Technology has great potential for supporting the learning needs of all young children in early childhood programs supported by the Reggio Emilia philosophy. This article discusses possible uses of technologies that are appropriate for young…

  1. Technological Innovation and Cooperation for Foreign Information Access Program

    Science.gov (United States)

    Office of Postsecondary Education, US Department of Education, 2012

    2012-01-01

    The Technological Innovation and Cooperation for Foreign Information Access (TICFIA) Program supports projects focused on developing innovative technologies for accessing, collecting, organizing, preserving, and disseminating information from foreign sources to address the U.S.' teaching and research needs in international education and foreign…

  2. Pollution reduction technology program for turboprop engines

    Science.gov (United States)

    Tomlinson, J. G.

    1977-01-01

    The reduction of CO, HC, and smoke emissions while maintaining acceptable NO(x) emissions without affecting fuel consumption, durability, maintainability, and safety was accomplished. Component combustor concept screening directed toward the demonstration of advanced combustor technology required to meet the EPA exhaust emissions standards for class P2 turboprop engines was covered. The combustion system for the Allison 501-D22A engine was used, and three combustor design concepts - reverse flow, prechamber, and staged fuel were evaluated.

  3. Massachusetts Institute of Technology, Plasma Fusion Center, Technical Research Programs

    International Nuclear Information System (INIS)

    1980-08-01

    A review is given of the technical programs carried out by the Plasma Fusion Center. The major divisions of work areas are applied plasma research, confinement experiments, fusion technology and engineering, and fusion systems. Some objectives and results of each program are described

  4. Massachusetts Institute of Technology, Plasma Fusion Center, Technical Research Programs

    Energy Technology Data Exchange (ETDEWEB)

    Davidson, Ronald C.

    1980-08-01

    A review is given of the technical programs carried out by the Plasma Fusion Center. The major divisions of work areas are applied plasma research, confinement experiments, fusion technology and engineering, and fusion systems. Some objectives and results of each program are described. (MOW)

  5. Marketing Social Service Programs Using Political Campaign Technology.

    Science.gov (United States)

    Bynum, Peter

    1991-01-01

    Discusses how human services agencies can use strategies and information technologies similar to those used in political campaigns to identify needs and attitudes for social services campaigns. Marketing for social services programs is described, and the use of computers for a political campaign and for a teenage pregnancy program is compared.…

  6. DOE Solar Energy Technologies Program FY 2005 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Sutula, Raymond A. [DOE Solar Energy Technologies Program, Washington, D.C. (United States)

    2006-03-01

    The DOE Solar Energy Technologies Program FY 2005 Annual Report chronicles the R&D results of the program for fiscal year 2005. In particular, the report describes R&D performed by the Program’s national laboratories and university and industry partners.

  7. 2009 DOE Vehicle Technologies Program Annual Merit Review

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-01

    Annual Merit Review and Peer Evaluation Meeting to review the FY2008 accomplishments and FY2009 plans for the Vehicle Technologies Program, and provide an opportunity for industry, government, and academic to give inputs to DOE on the Program with a structured and formal methodology.

  8. Cosmic Origins Program Annual Technology Report

    Science.gov (United States)

    Pham, Bruce Thai; Neff, Susan Gale

    2015-01-01

    What is the Cosmic Origins (COR) Program? From ancient times, humans have looked up at the night sky and wondered: Are we alone? How did the universe come to be? How does the universe work? COR focuses on the second question. Scientists investigating this broad theme seek to understand the origin and evolution of the universe from the Big Bang to the present day, determining how the expanding universe grew into a grand cosmic web of dark matter enmeshed with galaxies and pristine gas, forming, merging, and evolving over time. COR also seeks to understand how stars and planets form from clouds in these galaxies to create the heavy elements that are essential to life starting with the first generation of stars to seed the universe, and continuing through the birth and eventual death of all subsequent generations of stars. The COR Programs purview includes the majority of the field known as astronomy, from antiquity to the present.

  9. A continuing program for technology transfer to the apparel industry

    Science.gov (United States)

    Clingman, W. H.

    1971-01-01

    A six month program has been carried out to investigate various mechanisms for transferring technology to industry. This program has focused on transfer to the apparel industry through the Apparel Research Foundation. The procedure was to analyze the problem, obtain potentially relevant aerospace technology, and then transfer this technology to the industry organization. This was done in a specific case. Technology was identified relevant to stitchless joining, and this technology was transferred to the Apparel Research Foundation. The feasibility and ground rules for carrying out such activities on a broader scale were established. A specific objective was to transfer new technology from the industry organization to the industry itself. This required the establishment of an application engineering program. Another transfer mechanism tested was publication of solutions to industry problems in a format familiar to the industry. This is to be distinguished from circulating descriptions of new technology. Focus is on the industry problem and the manager is given a formula for solving it that he can follow. It was concluded that this mechanism can complement the problem statement approach to technology transfer. It is useful in achieving transfer when a large amount of application engineering is not necessary. A wide audience is immediately exposed to the technology. On the other hand, the major manufacturing problems which require a sophisticated technical solution integrating many innovations are less likely to be helped.

  10. Program Annual Technology Report: Cosmic Origins Program Office

    Science.gov (United States)

    Pham, Thai; Neff, Susan

    2017-01-01

    What is the Cosmic Origins (COR) Program? From ancient times, humans have looked up at the night sky and wondered: Are we alone? How did the universe come to be? How does the universe work? COR focuses on the second question. Scientists investigating this broad theme seek to understand the origin and evolution of the universe from the Big Bang to the present day, determining how the expanding universe grew into a grand cosmic web of dark matter enmeshed with galaxies and pristine gas, forming, merging, and evolving over time. COR also seeks to understand how stars and planets form from clouds in these galaxies to create the heavy elements that are essential to life, starting with the first generation of stars to seed the universe, and continuing through the birth and eventual death of all subsequent generations of stars. The COR Programs purview includes the majority of the field known as astronomy.

  11. Buildings R&D Breakthroughs: Technologies and Products Supported by the Building Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    Weakley, Steven A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2012-04-01

    The purpose of the project described in this report is to identify and characterize commercially available products and emerging (near-commercial) technologies that benefited from the support of the Building Technologies Program (BTP) within the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy. The investigation specifically focused on technology-oriented research and development (R&D) projects funded by BTP’s Emerging Technologies subprogram from 2005-2011.

  12. Buildings R&D Breakthroughs. Technologies and Products Supported by the Building Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-04-01

    This report identifies and characterizes commercially available products and emerging (near-commercial) technologies that benefited from the support of the Building Technologies Program (BTP) within the U.S. Department of Energy’s Office of Energy Efficiency and Renewable Energy. The investigation specifically focused on technology-oriented research and development (R&D) projects sponsored by BTP’s Emerging Technologies subprogram from 2005-2009.

  13. Early life experience contributes to the developmental programming of depressive-like behaviour, neuroinflammation and oxidative stress.

    Science.gov (United States)

    Réus, Gislaine Z; Fernandes, Gabrielly C; de Moura, Airam B; Silva, Ritele H; Darabas, Ana Caroline; de Souza, Thays G; Abelaira, Helena M; Carneiro, Celso; Wendhausen, Diogo; Michels, Monique; Pescador, Bruna; Dal-Pizzol, Felipe; Macêdo, Danielle S; Quevedo, João

    2017-12-01

    This study used an animal model of depression induced by maternal care deprivation (MCD) to investigate whether depressive behaviour, neuroinflammation and oxidative stress were underlying factors in developmental programming after early life stress. At postnatal days (PND) 20, 30, 40, and 60, individual subsets of animals were evaluated in behavioural tests and then euthanized to assess cytokine levels and oxidative stress parameters in the prefrontal cortex (PFC), hippocampus and serum. The results showed that MCD did not induce behavioural changes at PND 30 and 40. However, at PND 20 and 60, the rats displayed a depressive-like behaviour in the forced swimming test, without changes in locomotor spontaneous activity. In the brain and serum, the levels of pro-inflammatory cytokines (interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α)) were increased, and the anti-inflammatory cytokine (interleukin-10) level was reduced throughout developmental programming (PND 20, 30, 40 and 60). Protein carbonyl levels increased in the brain at PND 30, 40 and 60. Superoxide dismutase (SOD) activity was decreased during all developmental programming phases evaluated in the brain. Catalase (CAT) activity was decreased at PND 20, 40 and 60 in the brain. Our results revealed that "critical episodes" in early life stressful events are able to induce behavioural alterations that persist into adulthood and can stimulate inflammation and oxidative damage in both central and peripheral systems, which are required for distinct patterns of resilience against psychiatric disorders later in life. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Clean coal technologies: Research, development, and demonstration program plan

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    The US Department of Energy, Office of Fossil Energy, has structured an integrated program for research, development, and demonstration of clean coal technologies that will enable the nation to use its plentiful domestic coal resources while meeting environmental quality requirements. The program provides the basis for making coal a low-cost, environmentally sound energy choice for electric power generation and fuels production. These programs are briefly described.

  15. NDE Technology Development Program for Non-Visual Volumetric Inspection Technology; Sensor Effectiveness Testing Report

    Energy Technology Data Exchange (ETDEWEB)

    Moran, Traci L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Larche, Michael R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Denslow, Kayte M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Glass, Samuel W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-08-31

    The Pacific Northwest National Laboratory (PNNL) located in Richland, Washington, hosted and administered Sensor Effectiveness Testing that allowed four different participants to demonstrate the NDE volumetric inspection technologies that were previously demonstrated during the Technology Screening session. This document provides a Sensor Effectiveness Testing report for the final part of Phase I of a three-phase NDE Technology Development Program designed to identify and mature a system or set of non-visual volumetric NDE technologies for Hanford DST primary liner bottom inspection. Phase I of the program will baseline the performance of current or emerging non-visual volumetric NDE technologies for their ability to detect and characterize primary liner bottom flaws, and identify candidate technologies for adaptation and maturation for Phase II of the program.

  16. Parents of children with chronic health problems: programs of nursing research and their relationship to developmental science.

    Science.gov (United States)

    Miles, Margaret Shandor

    2003-01-01

    This review identified nurse researchers and research teams that have current programs of research focused on parents and parenting of children with chronic health problems. Researchers were included if they had at least five publications since 1990, with at least three of these articles first-authored. These programs of research were critiqued from a developmental science perspective. Multiple methods were used for the search, including examination of previous review articles, hand search of journals, online computer searches, and review of the curriculum vitae of authors. Seven programs of research were identified. Two programs of research focused on childhood cancer--Ida M. Martinson et al. and Marsha H. Cohen. Three programs of research used a noncategorical approach encompassing a variety of childhood chronic conditions--Katherine A. Knafl and Janet A. Deatrick, Sharon O. Burke, and Ann Garwick. One program focused primarily on parents of children with Down syndrome and disabilities--Marsha Van Riper--and another on parents of infants with a variety of chronic health problems--Margaret S. Miles and Diane Holditch-Davis. Diverse theories and conceptual frameworks were used, and most had some focus on ecological systems that might affect parents and parenting. Many used a family perspective and included fathers. Still broader aspects of the family and community ecology and the health care were not generally included. Few examined the bidirectionality of the relationship between the child and aspects of the child's illness and parental responses. There was variability in the extent to which ethnicity and socioeconomic status were considered. Studies provide important insight into the responses of parents and their parenting of children with chronic health problems. The studies provide a sound base for continuing to build a developmentally sensitive body of knowledge related to parents and parenting of the child with chronic health problems.

  17. Repository Technology Program activities, FY 1988

    International Nuclear Information System (INIS)

    Yow, J.L. Jr.; Wijesinghe, A.M.; Thorpe, R.K.; Knapp, R.B.

    1989-07-01

    Our technical activities in FY 1988 included instrument selection and evaluation, calculational work, and simulator development. Near the end of the fiscal year, we began preparing several topical reports to document our results. This fiscal year, we continued developing three-dimensional numerical simulators to model coupled hydrologic-and mechanical-rock mass responses and, thus, to provide representative numerical tools for understanding and calculating these in situ processes. We also began scoping calculations in the second half of FY 1988 to evaluate ERE design criteria, but this work was redirected late in the year when the DOE/AECL Subsidiary Agreement was set aside. Our work in developing and evaluating experimental techniques focused on total pressure measurements, moisture content measurement, and tracer detection instrumentation for sealing experiments and for rock-mass-response field tests. At the end of the fiscal year, we completed a review of measurement technology for instrumenting migration/sorption tests to help define the technological requirements in these areas. By the end of FY 1988, we had completed a review of the existing codes for simulating reactive transport; we are using the results of this review to help formulate plans for future activities in this area. The following sections describe the major RTP tasks and activities at LLNL in more detail, and they include our FY 1988 accomplishments in these areas. 8 refs., 22 figs

  18. Physical security technology base programs for physical security

    International Nuclear Information System (INIS)

    Jacobs, J.

    1986-01-01

    Sandia National Laboratories is the US Department of Energy's lead laboratory for physical security research and development (R and D). In support of this mission, Sandia has maintained for several years an R and D program in each of the following technology areas: Intrusion Detection, Entry Control, CCTV Assessment, Access Delay, Alarm Display, and Guard Equipment and Training. The purpose of the technology base programs is to maintain cognizance of the capabilities of the commercial market, identify improvements and transfer technology to industry and facilities. The output of these programs supports the development of new equipment and advanced system concepts, demonstrations of proof-of-principles and system implementation. This paper will review the status of current developments and discuss trends in new technologies which are being explored for future applications, i.e., artificial intelligence, expert systems, robotics, and more automated systems

  19. Cosmic Origins Program Annual Technology Report

    Science.gov (United States)

    Pham, Bruce Thai; Neff, Susan Gale

    2016-01-01

    What is the Cosmic Origins (COR) Program? From ancient times, humans have looked up at the night sky and wondered: Are we alone? How did the universe come to be? How does the universe work? COR focuses on the second question. Scientists investigating this broad theme seek to understand the origin and evolution of the universe from the Big Bang to the present day, determining how the expanding universe grew into a grand cosmic web of dark matter enmeshed with galaxies and pristine gas, forming, merging, and evolving over time.

  20. 78 FR 39271 - Applications for New Awards; Educational Technology, Media, and Materials Program for Individuals...

    Science.gov (United States)

    2013-07-01

    ... DEPARTMENT OF EDUCATION Applications for New Awards; Educational Technology, Media, and Materials...: Educational Technology, Media, and Materials Program for Individuals with Disabilities--Center on Technology... Description Purpose of Program: The purpose of the Educational Technology, Media, and Materials for...

  1. Environmental restoration and waste management: Robotics technology development program: Robotics 5-year program plan

    International Nuclear Information System (INIS)

    1991-01-01

    This plan covers robotics Research, Development, Demonstration, Testing and Evaluation activities in the Program for the next five years. These activities range from bench-scale R ampersand D to full-scale hot demonstrations at DOE sites. This plan outlines applications of existing technology to near-term needs, the development and application of enhanced technology for longer-term needs, and initiation of advanced technology development to meet those needs beyond the five-year plan. The objective of the Robotic Technology Development Program (RTDP) is to develop and apply robotics technologies that will enable Environmental Restoration and Waste Management (ER ampersand WM) operations at DOE sites to be safer, faster and cheaper. Five priority DOE sites were visited in March 1990 to identify needs for robotics technology in ER ampersand WM operations. This 5-Year Program Plan for the RTDP detailed annual plans for robotics technology development based on identified needs. In July 1990 a forum was held announcing the robotics program. Over 60 organizations (industrial, university, and federal laboratory) made presentations on their robotics capabilities. To stimulate early interactions with the ER ampersand WM activities at DOE sites, as well as with the robotics community, the RTDP sponsored four technology demonstrations related to ER ampersand WM needs. These demonstrations integrated commercial technology with robotics technology developed by DOE in support of areas such as nuclear reactor maintenance and the civilian reactor waste program. 2 figs

  2. Superconducting Technology Program: Sandia 1993 annual report

    International Nuclear Information System (INIS)

    Roth, E.P.

    1994-05-01

    Sandia's STP program is a four-part high-temperature superconductor (HTS) research and development program consisting of efforts in powder synthesis and process development, thallium-based HTS film development, wire and tape fabrication, and HTS motor design. The objective of this work is to develop high-temperature superconducting conductors (wire and tape) capable of meeting requirements for high-power electrical devices of interest to industry. The four research efforts currently underway are: (1) process research on the material synthesis of high-temperature superconductors; (2) investigation of the synthesis and processing of thallium-based high-temperature superconducting thick films; (3) process development and characterization of high-temperature superconducting wire and tape, and (4) cryogenic design of a high-temperature superconducting motor. This report outlines the research that has been performed during FY93 in each of these four areas. A brief background of each project is included to provide historical context and perspective. Major areas of research are described, although no attempt has been made to exhaustively include all work performed in each of these areas

  3. An overview of DARPA's advanced space technology program

    Science.gov (United States)

    Nicastri, E.; Dodd, J.

    1993-02-01

    The Defense Advanced Research Projects Agency (DARPA) is the central research and development organization of the DoD and, as such, has the primary responsibility for the maintenance of U.S. technological superiority over potential adversaries. DARPA's programs focus on technology development and proof-of-concept demonstrations of both evolutionary and revolutionary approaches for improved strategic, conventional, rapid deployment and sea power forces, and on the scientific investigation into advanced basic technologies of the future. DARPA can move quickly to exploit new ideas and concepts by working directly with industry and universities. For four years, DARPA's Advanced Space Technology Program (ASTP) has addressed various ways to improve the performance of small satellites and launch vehicles. The advanced technologies that are being and will be developed by DARPA for small satellites can be used just as easily on large satellites. The primary objective of the ASTP is to enhance support to operational commanders by developing and applying advanced technologies that will provide cost-effective, timely, flexible, and responsive space systems. Fundamental to the ASTP effort is finding new ways to do business with the goal of quickly inserting new technologies into DoD space systems while reducing cost. In our view, these methods are prime examples of what may be termed 'technology leveraging.' The ASTP has initiated over 50 technology projects, many of which were completed and transitioned to users. The objectives are to quickly qualify these higher risk technologies for use on future programs and reduce the risk of inserting these technologies into major systems, and to provide the miniaturized systems that would enable smaller satellites to have significant - rather than limited - capability. Only a few of the advanced technologies are described, the majority of which are applicable to both large and small satellites.

  4. A model technology transfer program for independent operators

    Energy Technology Data Exchange (ETDEWEB)

    Schoeling, L.G.

    1996-08-01

    In August 1992, the Energy Research Center (ERC) at the University of Kansas was awarded a contract by the US Department of Energy (DOE) to develop a technology transfer regional model. This report describes the development and testing of the Kansas Technology Transfer Model (KTTM) which is to be utilized as a regional model for the development of other technology transfer programs for independent operators throughout oil-producing regions in the US. It describes the linkage of the regional model with a proposed national technology transfer plan, an evaluation technique for improving and assessing the model, and the methodology which makes it adaptable on a regional basis. The report also describes management concepts helpful in managing a technology transfer program.

  5. Status of 2 micron laser technology program

    Science.gov (United States)

    Storm, Mark

    1991-01-01

    The status of 2 micron lasers for windshear detection is described in viewgraph form Theoretical atmospheric and instrument system studies have demonstrated that the 2.1 micron Ho:YAG lasers can effectively measure wind speeds in both wet and dry conditions with accuracies of 1 m/sec. Two micron laser technology looks very promising in the near future, but several technical questions remain. The Ho:YAG laser would be small, compact, and efficient, requiring little or no maintenance. Since the Ho:YAG laser is laser diode pumped and has no moving part, the lifetime of this laser would be directly related to the diode laser lifetimes which can perform in excess of 10,000 hours. Efficiencies of 3 to 12 percent are expected, but laser demonstrations confirming the ability to Q-switch this laser are required. Coherent laser operation has been demonstrated for both the CW and Q-switched lasers.

  6. Developmental programming: Impact of prenatal testosterone treatment and postnatal obesity on ovarian follicular dynamics

    OpenAIRE

    Padmanabhan, V; Smith, P; Veiga-Lopez, A

    2012-01-01

    Prenatal testosterone (T) excess leads to reproductive dysfunctions in sheep with obesity exaggerating such defects. Developmental studies found ovarian reserve is similar in control and prenatal T sheep at fetal day 140, with prenatal T females showing increased follicular recruitment and persistence at 10 months of age (postpubertal). This study tested if prenatal T sheep show accelerated depletion prepubertally and if depletion of ovarian reserve would explain loss of cyclicity in prenatal...

  7. The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Renee Wei-Yan Chow

    2017-04-01

    Full Text Available The zebrafish (Danio rerio is a powerful vertebrate model to study cellular and developmental processes in vivo. The optical clarity and their amenability to genetic manipulation make zebrafish a model of choice when it comes to applying optical techniques involving genetically encoded photoresponsive protein technologies. In recent years, a number of fluorescent protein and optogenetic technologies have emerged that allow new ways to visualize, quantify, and perturb developmental dynamics. Here, we explain the principles of these new tools and describe some of their representative applications in zebrafish.

  8. Program Annual Technology Report: Physics of the Cosmos Program Office

    Science.gov (United States)

    Pham, Bruce Thai; Cardiff, Ann H.

    2017-01-01

    From ancient times, humans have looked up at the night sky and wondered: Are we alone? How did the universe come to be? How does the universe work? PCOS focuses on that last question. Scientists investigating this broad theme use the universe as their laboratory, investigating its fundamental laws and properties. They test Einstein’s General Theory of Relativity to see if our current understanding of space-time is borne out by observations. They examine the behavior of the most extreme environments – supermassive black holes, active galactic nuclei, and others – and the farthest reaches of the universe, to expand our understanding. With instruments sensitive across the spectrum, from radio, through infrared (IR), visible light, ultraviolet (UV), to X rays and gamma rays, as well as gravitational waves (GWs), they peer across billions of light-years, observing echoes of events that occurred instants after the Big Bang. Last year, the LISA Pathfinder (LPF) mission exceeded expectations in proving the maturity of technologies needed for the Laser Interferometer Space Antenna (LISA) mission, and the Laser Interferometer Gravitational-Wave Observatory (LIGO) recorded the first direct measurements of long-theorized GWs. Another surprising recent discovery is that the universe is expanding at an ever-accelerating rate, the first hint of so-called “dark energy,” estimated to account for 75% of mass-energy in the universe. Dark matter, so called because we can only observe its effects on regular matter, is thought to account for another20%, leaving only 5% for regular matter and energy. Scientists now also search for special polarization in the cosmic microwave background to support the notion that in the split-second after the Big Bang, the universe inflated faster than the speed of light! The most exciting aspect of this grand enterprise today is the extraordinary rate at which we can harness technologies to enable these key discoveries.

  9. Systems autonomy technology: Executive summary and program plan

    Science.gov (United States)

    Bull, John S (Editor)

    1987-01-01

    The National Space Strategy approved by the President and Congress in 1984 sets for NASA a major goal of conducting effective and productive space applications and technology programs which contribute materially toward United States leadership and security. To contribute to this goal, OAST supports the Nation's civil and defense space programs and overall economic growth. OAST objectives are to ensure timely provision of new concepts and advanced technologies, to support both the development of NASA missions in space and the space activities of industry and other organizations, to utilize the strengths of universities in conducting the NASA space research and technology program, and to maintain the NASA centers in positions of strength in critical space technology areas. In line with these objectives, NASA has established a new program in space automation and robotics that will result in the development and transfer and automation technology to increase the capabilities, productivity, and safety of NASA space programs including the Space Station, automated space platforms, lunar bases, Mars missions, and other deep space ventures. The NASA/OAST Automation and Robotics program is divided into two parts. Ames Research Center has the lead role in developing and demonstrating System Autonomy capabilities for space systems that need to make their own decisions and do their own planning. The Jet Propulsion Laboratory has the lead role for Telerobotics (that portion of the program that has a strong human operator component in the control loop and some remote handling requirement in space). This program is intended to be a working document for NASA Headquarters, Program Offices, and implementing Project Management.

  10. Fetal, maternal, and placental sources of serotonin and new implications for developmental programming of the brain.

    Science.gov (United States)

    Bonnin, A; Levitt, P

    2011-12-01

    In addition to its role in neurotransmission, embryonic serotonin (5-HT) has been implicated in the regulation of neurodevelopmental processes. For example, we recently showed that a subset of 5-HT1-receptors expressed in the fetal forebrain mediate a serotonergic modulation of thalamocortical axons response to axon guidance cues, both in vitro and in vivo. This influence of 5-HT signaling on fetal brain wiring raised important questions regarding the source of the ligand during pregnancy. Until recently, it was thought that 5-HT sources impacting brain development arose from maternal transport to the fetus, or from raphe neurons in the brainstem of the fetus. Using genetic mouse models, we uncovered previously unknown differences in 5-HT accumulation between the fore- and hindbrain during early and late fetal stages, through an exogenous source of 5-HT. Using additional genetic strategies, a new technology for studying placental biology ex vivo, and direct manipulation of placental neosynthesis, we investigated the nature of this exogenous source and uncovered a placental 5-HT synthetic pathway from a maternal tryptophan precursor, in both mice and humans. These results implicate a new, direct role for placental metabolic pathways in modulating fetal brain development and suggest an important role for maternal-placental-fetal interactions and 5-HT in the fetal programming of adult mental disorders. Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.

  11. Vehicle Technologies and Fuel Cell Technologies Program: Prospective Benefits Assessment Report for Fiscal Year 2016

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, T. S. [Argonne National Lab. (ANL), Argonne, IL (United States); Taylor, C. H. [TA Engineering, Inc., Catonsville, MD (United States); Moore, J. S. [TA Engineering, Inc., Catonsville, MD (United States); Ward, J. [United States Department of Energy, Washington, DC (United States). Office of Energy Efficiency and Renewable Energy

    2016-02-23

    Under a diverse set of programs, the Vehicle Technologies and Fuel Cell Technologies offices of DOE’s Office of Energy Efficiency and Renewable Energy invest in research, development, demonstration, and deployment of advanced vehicle, hydrogen production, delivery and storage, and fuel cell technologies. This report estimates the benefits of successfully developing and deploying these technologies (a “Program Success” case) relative to a base case (the “No Program” case). The Program Success case represents the future with completely successful deployment of Vehicle Technologies Office (VTO) and Fuel Cell Technologies Office (FCTO) technologies. The No Program case represents a future in which there is no contribution after FY 2016 by the VTO or FCTO to these technologies. The benefits of advanced vehicle, hydrogen production, delivery and storage, and fuel cell technologies were estimated on the basis of differences in fuel use, primary energy use, and greenhouse gas (GHG) emissions from light-, medium- and heavy-duty vehicles, including energy and emissions from fuel production, between the base case and the Program Success case. Improvements in fuel economy of various vehicle types, growth in the stock of fuel cell vehicles and other advanced technology vehicles, and decreased GHG intensity of hydrogen production and delivery in the Program Success case over the No Program case were projected to result in savings in petroleum use and GHG emissions. Benefits were disaggregated by individual program technology areas, which included the FCTO program and the VTO subprograms of batteries and electric drives; advanced combustion engines; fuels and lubricants; materials (for reduction in vehicle mass, or “lightweighting”); and, for medium- and heavy-duty vehicles, reduction in rolling and aerodynamic resistance. Projections for the Program Success case indicate that by 2035, the average fuel economy of on-road, light-duty vehicle stock could be 47% to 76

  12. Progress Twining Program at Shibaura Institute of Technology

    Science.gov (United States)

    Komeda, Takashi

    The Shibaura Institute of Technology (SIT) conducts two Twinning Programs. One is Malaysian Twinning Program, which is conducted in cooperation with 15 Japanese universities, and has SIT as its organizing member. The other is Hybrid Twinning Program, which is conducted with partner foreign universities, and is a graduate study program combining Masters and Doctoral programs. Two important reasons for conducting these twinning programs are to increase the number of foreign students studying in Japan and to promote friendly relations with various Asian countries. Twinning program is effective in enrolling students early and in lowering the cost of foreign study. Japanese students benefit too from good influence of interaction with students having a different culture and customs.

  13. Exploratory Technology Research Program for electrochemical energy storage

    Science.gov (United States)

    Kinoshita, Kim

    1994-09-01

    The U.S. Department of Energy's Office of Propulsion Systems provides support for an Electrochemical Energy Storage Program, that includes research and development (R&D) on advanced rechargeable batteries and fuel cells. A major goal of this program is to develop electrochemical power sources suitable for application in electric vehicles (EV's). The program centers on advanced systems that offer the potential for high performance and low life-cycle costs, both of which are necessary to permit significant penetration into commercial markets. The DOE Electrochemical Energy Storage Program is divided into two projects: the Electric Vehicle Advanced Battery Systems (EVABS) Development Program and the Exploratory Technology Research (ETR) Program. The EVABS Program management responsibility has been assigned to Sandia National Laboratories (SNL); Lawrence Berkeley Laboratory (LBL) is responsible for management of the ETR Program. The EVABS and ETR Programs include an integrated matrix of R&D efforts designed to advance progress on selected candidate electrochemical systems. The United States Advanced Battery Consortium (USABC), a tripartite undertaking between DOE, the U.S. automobile manufacturers and the Electric Power Research Institute (EPRI), was formed in 1991 to accelerate the development of advanced batteries for consumer EV's. The role of the FIR Program is to perform supporting research on the advanced battery systems under development by the USABC and EVABS Program, and to evaluate new systems with potentially superior performance, durability and/or cost characteristics. The specific goal of the ETR Program is to identify the most promising electrochemical technologies and transfer them to the USABC, the battery industry and/or the EVABS Program for further development and scale-up. This report summarizes the research, financial and management activities relevant to the ETR Program in CY 1993.

  14. Early-postnatal changes in adiposity and lipids profile by transgenerational developmental programming in swine with obesity/leptin resistance.

    Science.gov (United States)

    Gonzalez-Bulnes, Antonio; Astiz, Susana; Ovilo, Cristina; Lopez-Bote, Clemente J; Sanchez-Sanchez, Raul; Perez-Solana, Maria L; Torres-Rovira, Laura; Ayuso, Miriam; Gonzalez, Jorge

    2014-10-01

    Maternal malnutrition during pregnancy, both deficiency and excess, induces changes in the intrauterine environment and the metabolic status of the offspring, playing a key role in the growth, status of fitness/obesity and appearance of metabolic disorders during postnatal life. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations. This study evaluated, in a swine model of obesity/leptin resistance, the existence and extent of transgenerational developmental programming effects. Pre- and postnatal development, adiposity and metabolic features were assessed in the second generation of piglets, descendant of sows exposed to either undernutrition or overnutrition during pregnancy. The results indicated that these piglets exhibited early-postnatal increases in adiposity and disturbances in lipid profiles compatible with the early prodrome of metabolic syndrome, with liver tissue also displaying evidence of paediatric liver disease. These features indicative of early-life metabolic disorders were more evident in the males that were descended from overfed grandmothers and during the transition from milk to solid feeding. Thus, this study provides evidence supporting transgenerational developmental programming and supports the necessity for the development of strategies for avoiding the current epidemics of childhood overweight and obesity. © 2014 Society for Endocrinology.

  15. Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice.

    Science.gov (United States)

    Nohara, Kazunari; Waraich, Rizwana S; Liu, Suhuan; Ferron, Mathieu; Waget, Aurélie; Meyers, Matthew S; Karsenty, Gérard; Burcelin, Rémy; Mauvais-Jarvis, Franck

    2013-06-15

    Among women, the polycystic ovarian syndrome (PCOS) is considered a form of metabolic syndrome with reproductive abnormalities. Women with PCOS show increased sympathetic tone, visceral adiposity with enlarged adipocytes, hypoadiponectinemia, insulin resistance, glucose intolerance, increased inactive osteocalcin, and hypertension. Excess fetal exposure to androgens has been hypothesized to play a role in the pathogenesis of PCOS. Previously, we showed that neonatal exposure to the androgen testosterone (NT) programs leptin resistance in adult female mice. Here, we studied the impact of NT on lean and adipose tissues, sympathetic tone in cardiometabolic tissues, and the development of metabolic dysfunction in mice. Neonatally androgenized adult female mice (NTF) displayed masculinization of lean tissues with increased cardiac and skeletal muscle as well as kidney masses. NTF mice showed increased and dysfunctional white adipose tissue with increased sympathetic tone in both visceral and subcutaneous fat as well as increased number of enlarged and insulin-resistant adipocytes that displayed altered expression of developmental genes and hypoadiponectinemia. NTF exhibited dysfunctional brown adipose tissue with increased mass and decreased energy expenditure. They also displayed decreased undercarboxylated and active osteocalcin and were predisposed to obesity during chronic androgen excess. NTF showed increased renal sympathetic tone associated with increased blood pressure, and they developed glucose intolerance and insulin resistance. Thus, developmental exposure to testosterone in female mice programs features of cardiometabolic dysfunction, as can be observed in women with PCOS, including increased sympathetic tone, visceral adiposity, insulin resistance, prediabetes, and hypertension.

  16. Physics of the Cosmos (PCOS) Technology Development Program Overview

    Science.gov (United States)

    Pham, B. Thai; Clampin, M.; Werneth, R. L.

    2014-01-01

    The Physics of the Cosmos (PCOS) Program Office was established in FY11 and resides at the NASA Goddard Space Flight Center (GSFC). The office serves as the implementation arm for the Astrophysics Division at NASA Headquarters for PCOS Program related matters. We present an overview of the Program’s technology management activities and the Program’s technology development portfolio. We discuss the process for addressing community-provided technology needs and the Technology Management Board (TMB)-vetted prioritization and investment recommendations. This process improves the transparency and relevance of technology investments, provides the community a voice in the process, and leverages the technology investments of external organizations by defining a need and a customer. Goals for the PCOS Program envisioned by the National Research Council’s (NRC) “New Worlds, New Horizons in Astronomy and Astrophysics” (NWNH) Decadal Survey report include science missions and technology development for dark energy, gravitational waves, X-ray, and inflation probe science.

  17. Identifying state resources and support programs on e-government websites for persons with intellectual and developmental disabilities.

    Science.gov (United States)

    Fisher, Kathleen M; Peterson, Justin D; Albert, Jon D

    2015-01-01

    This descriptive cross-sectional study identified resources and programs that are available nationwide on the Internet to support individuals and families with intellectual and developmental disabilities (I/DD), with a focus on intellectual disability. This evaluation included easily identifiable information on specific resources and highlighted unique programs found in individual states that were linked from e-government websites. Researchers documented the ease of access and available information for all 50 states and the District of Columbia. A number of disparities and areas for improvement were recorded for states and I/DD websites. The researchers conclude that a number of additional health and support services will be needed to address the growing needs of this vulnerable population.

  18. Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy

    DEFF Research Database (Denmark)

    Armitage, James A.; Lakasing, Lorin; Taylor, Paul D.

    2005-01-01

    Evidence from human and animal studies suggests that maternal nutrition can induce developmental programming of adult hypertension in offspring. We have previously described a model of maternal dietary imbalance in Sprague-Dawley rats whereby administration of a maternal diet rich in animal lard......-Dawley rats fed a control diet (OC) or lard-rich diet (OHF) during pregnancy and suckling followed by a control diet post-weaning. To gain further insight, we assessed aortic reactivity and elasticity in an organ bath preparation and renal renin and Na+,K+-ATPase activity. Plasma aldosterone concentration...... weight, glomerular number or volume in OHF compared with OC, but renin and Na+,K+-ATPase activity were significantly reduced in OHF compared with controls. Programmed alterations to aortic structure and function are consistent with previous observations that exposure to maternal high fat diets produces...

  19. NASA's Advanced Information Systems Technology (AIST) Program: Advanced Concepts and Disruptive Technologies

    Science.gov (United States)

    Little, M. M.; Moe, K.; Komar, G.

    2014-12-01

    NASA's Earth Science Technology Office (ESTO) manages a wide range of information technology projects under the Advanced Information Systems Technology (AIST) Program. The AIST Program aims to support all phases of NASA's Earth Science program with the goal of enabling new observations and information products, increasing the accessibility and use of Earth observations, and reducing the risk and cost of satellite and ground based information systems. Recent initiatives feature computational technologies to improve information extracted from data streams or model outputs and researchers' tools for Big Data analytics. Data-centric technologies enable research communities to facilitate collaboration and increase the speed with which results are produced and published. In the future NASA anticipates more small satellites (e.g., CubeSats), mobile drones and ground-based in-situ sensors will advance the state-of-the-art regarding how scientific observations are performed, given the flexibility, cost and deployment advantages of new operations technologies. This paper reviews the success of the program and the lessons learned. Infusion of these technologies is challenging and the paper discusses the obstacles and strategies to adoption by the earth science research and application efforts. It also describes alternative perspectives for the future program direction and for realizing the value in the steps to transform observations from sensors to data, to information, and to knowledge, namely: sensor measurement concepts development; data acquisition and management; data product generation; and data exploitation for science and applications.

  20. Assessing the Effectiveness of a Mathematics-Focused, Instructional Technology Program for Grades 6-8: A 5-Year Trend Analysis of NASA CONNECT(tm) Evaluation Data

    Science.gov (United States)

    Glassman, Nanci A.; Perry, Jeannine B.; Giersch, Christopher E.; Lambert, Matthew A.; Pinelli, Thomas E.

    2004-01-01

    NASA CONNECT is a research-, inquiry, and standards-based, integrated mathematics, science, and technology series of 30-minute instructional distance learning (television and web-based) programs for students in grades 6 8. Respondents who evaluated the programs in the series over the first five seasons (1998-99 through 2002-03) reported that (1) they used the programs in the series; (2) the goals and objectives for the series were met; (3) the programs were aligned with the national mathematics, science, and technology standards; (4) the program content was developmentally appropriate for the grade level; and (5) the programs in the series enhanced and enriched the teaching of mathematics, science, and technology.

  1. Invention Development Program Helps Nurture NCI at Frederick Technologies | Poster

    Science.gov (United States)

    The Invention Development Fund (IDF) was piloted by the Technology Transfer Center (TTC) in 2014 to facilitate the commercial development of NCI technologies. The IDF received a second round of funding from the NCI Office of the Director and the Office of Budget and Management to establish the Invention Development Program (IDP) for fiscal year 2016. The IDP is using these funds to help advance a second set of inventions.

  2. Fossil Energy Advanced Research and Technology Development Materials Program

    Energy Technology Data Exchange (ETDEWEB)

    Cole, N.C.; Judkins, R.R. (comps.)

    1992-12-01

    Objective of this materials program is to conduct R and D on materials for fossil energy applications with focus on longer-term and generic needs of the various fossil fuel technologies. The projects are organized according to materials research areas: (1) ceramics, (2) new alloys: iron aluminides, advanced austenitics and chromium niobium alloys, and (3) technology development and transfer. Separate abstracts have been prepared.

  3. Overcoming regulatory barriers: DOE environmental technology development program

    International Nuclear Information System (INIS)

    Kurtyka, B.M.; Clodfelter-Schumack, K.; Evans, T.T.

    1995-01-01

    The potential to improve environmental conditions via compliance or restoration is directly related to the ability to produce and apply innovative technological solutions. However, numerous organizations, including the US General Accounting Office (GAO), the EPA National Advisory Council for Environmental Policy and Technology (NACEPT), the DOE Environmental Management Advisory Board (EMAB), and the National Science and Technology Council (NSTC) have determined that significant regulatory barriers exist that inhibit the development and application of these technologies. They have noted the need for improved efforts in identifying and rectifying these barriers for the purpose of improving the technology development process, providing innovative alternatives, and enhancing the likelihood of technology acceptance by all. These barriers include, among others, regulator and user bias against ''unknown/unproven'' technologies; multi-level/multi-media permit disincentives; potential liability of developers and users for failed implementation; wrongly defined or inadequate data quality objectives: and lack of customer understanding and input. The ultimate goal of technology development is the utilization of technologies. This paper will present information on a number of regulatory barriers hindering DOE's environmental technology development program and describe DOE efforts to address these barriers

  4. Building technological capability within satellite programs in developing countries

    Science.gov (United States)

    Wood, Danielle; Weigel, Annalisa

    2011-12-01

    This paper explores the process of building technological capability in government-led satellite programs within developing countries. The key message is that these satellite programs can learn useful lessons from literature in the international development community. These lessons are relevant to emerging satellite programs that leverage international partnerships in order to establish local capability to design, build and operate satellites. Countries with such programs include Algeria, Nigeria, Turkey, Malaysia and the United Arab Emirates. The paper first provides background knowledge about space activity in developing countries, and then explores the nuances of the lessons coming from the international development literature. Developing countries are concerned with satellite technology because satellites provide useful services in the areas of earth observation, communication, navigation and science. Most developing countries access satellite services through indirect means such as sharing data with foreign organizations. More countries, however, are seeking opportunities to develop satellite technology locally. There are objective, technically driven motivations for developing countries to invest in satellite technology, despite rich debate on this topic. The paper provides a framework to understand technical motivations for investment in satellite services, hardware, expertise and infrastructure in both short and long term. If a country decides to pursue such investments they face a common set of strategic decisions at the levels of their satellite program, their national context and their international relationships. Analysis of past projects shows that countries have chosen diverse strategies to address these strategic decisions and grow in technological capability. What is similar about the historical examples is that many countries choose to leverage international partnerships as part of their growth process. There are also historical examples from

  5. Bioremediation Education Science and Technology (BEST) Program Annual Report 1999

    Energy Technology Data Exchange (ETDEWEB)

    Hazen, Terry C.

    2000-07-01

    The Bioremediation, Education, Science and Technology (BEST) partnership provides a sustainable and contemporary approach to developing new bioremedial technologies for US Department of Defense (DoD) priority contaminants while increasing the representation of underrepresented minorities and women in an exciting new biotechnical field. This comprehensive and innovative bioremediation education program provides under-represented groups with a cross-disciplinary bioremediation cirruculum and financial support, coupled with relevant training experiences at advanced research laboratories and field sites. These programs are designed to provide a stream of highly trained minority and women professionals to meet national environmental needs.

  6. Small Business Innovation Research and Small Business Technology Transfer Programs

    Science.gov (United States)

    Garrison, Lynn; Jasper, Gwen

    2015-01-01

    The Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) programs fund the research, development, and demonstration of innovative technologies that fulfill NASA's needs as described in the annual Solicitations and have significant potential for successful commercialization. The only eligible participants are small business concern (SBC) with 500 or fewer employees or a nonprofit research institute such as a university or a research laboratory with ties to an SBC. These programs are potential sources of seed funding for the development of small business innovations.

  7. The need for a fusion technology information program

    International Nuclear Information System (INIS)

    Correll, D.L. Jr.

    1987-01-01

    In providing an adequate energy technology for the future, which new programs should be considered by the Department of Energy national laboratories to ensure that the US remains in the forefront of international science and technology is an important question. This paper suggests that the urgency for energy independence demands an active communication program that would increase awareness of energy as a critical national issue and would present fusion, with its benefits and risks, as one of the long-term alternative energy sources

  8. The need for a fusion technology information program

    Energy Technology Data Exchange (ETDEWEB)

    Correll, D.L. Jr.

    1987-06-16

    In providing an adequate energy technology for the future, which new programs should be considered by the Department of Energy national laboratories to ensure that the US remains in the forefront of international science and technology is an important question. This paper suggests that the urgency for energy independence demands an active communication program that would increase awareness of energy as a critical national issue and would present fusion, with its benefits and risks, as one of the long-term alternative energy sources.

  9. Laser Science and Technology Program Annual Report - 2000

    International Nuclear Information System (INIS)

    Chen, H-L

    2001-01-01

    The Laser Science and Technology (LSandT) Program Annual Report 2001 provides documentation of the achievements of the LLNL LSandT Program during the April 2001 to March 2002 period using three formats: (1) an Overview that is a narrative summary of important results for the year; (2) brief summaries of research and development activity highlights within the four Program elements: Advanced Lasers and Components (ALandC), Laser Optics and Materials (LOandM), Short Pulse Laser Applications and Technologies (SPLAT), and High-Energy Laser System and Tests (HELST); and (3) a compilation of selected articles and technical reports published in reputable scientific or technology journals in this period. All three elements (Annual Overview, Activity Highlights, and Technical Reports) are also on the Web: http://laser.llnl.gov/lasers/pubs/icfq.html. The underlying mission for the LSandT Program is to develop advanced lasers, optics, and materials technologies and applications to solve problems and create new capabilities of importance to the Laboratory and the nation. This mission statement has been our guide for defining work appropriate for our Program. A major new focus of LSandT beginning this past year has been the development of high peak power short-pulse capability for the National Ignition Facility (NIF). LSandT is committed to this activity

  10. Overview of the Defense Programs Research and Technology Development Program for Fiscal Year 1993

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This documents presents a programmatic overview and program element plan summaries for conceptual design and assessment; physics; computation and modeling; system engineering science and technology; electronics, photonics, sensors, and mechanical components; chemistry and materials; special nuclear materials, tritium, and explosives.

  11. NASA Johnson Space Center SBIR STTR Program Technology Innovations

    Science.gov (United States)

    Krishen, Kumar

    2007-01-01

    The Small Business Innovation Research (SBIR) Program increases opportunities for small businesses to participate in research and development (R&D), increases employment, and improves U.S. competitiveness. Specifically the program stimulates U.S. technological innovation by using small businesses to meet federal R&D needs, increasing private-sector commercialization of innovations derived from federal R&D, and fostering and encouraging the participation of socially disadvantaged businesses. In 2000, the Small Business Technology Transfer (STTR) Program extended and strengthened the SBIR Program, increasing its emphasis on pursuing commercial applications by awarding contracts to small business concerns for cooperative R&D with a nonprofit research institution. Modeled after the SBIR Program, STTR is nevertheless a separately funded activity. Technologies that have resulted from the Johnson Space Center SBIR STTR Program include: a device for regenerating iodinated resin beds; laser-assisted in-situ keratomileusis or LASIK; a miniature physiological monitoring device capable of collecting and analyzing a multitude of real-time signals to transmit medical data from remote locations to medical centers for diagnosis and intervention; a new thermal management system for fibers and fabrics giving rise to new line of garments and thermal-enhancing environments; and a highly electropositive material that attracts and retains electronegative particles in water.

  12. NASA Program Office Technology Investments to Enable Future Missions

    Science.gov (United States)

    Thronson, Harley; Pham, Thai; Ganel, Opher

    2018-01-01

    The Cosmic Origins (COR) and Physics of the Cosmos (PCOS) Program Offices (POs) reside at NASA GSFC and implement priorities for the NASA HQ Astrophysics Division (APD). One major aspect of the POs’ activities is managing our Strategic Astrophysics Technology (SAT) program to mature technologies for future strategic missions. The Programs follow APD guidance on which missions are strategic, currently informed by the NRC’s 2010 Decadal Survey report, as well as APD’s Implementation Plan and the Astrophysics Roadmap.In preparation for the upcoming 2020 Decadal Survey, the APD has established Science and Technology Definition Teams (STDTs) to study four large-mission concepts: the Origins Space Telescope (née, Far-IR Surveyor), Habitable Exoplanet Imaging Mission, Large UV/Optical/IR Surveyor, and Lynx (née, X-ray Surveyor). The STDTs will develop the science case and design reference mission, assess technology development needs, and estimate the cost of their concept. A fifth team, the L3 Study Team (L3ST), was charged to study potential US contributions to ESA’s planned Laser Interferometer Space Antenna (LISA) gravitational-wave observatory.The POs use a rigorous and transparent process to solicit technology gaps from the scientific and technical communities, and prioritize those entries based on strategic alignment, expected impact, cross-cutting applicability, and urgency. For the past two years, the technology-gap assessments of the four STDTs and the L3ST are included in our process. Until a study team submits its final report, community-proposed changes to gaps submitted or adopted by a study team are forwarded to that study team for consideration.We discuss our technology development process, with strategic prioritization informing calls for SAT proposals and informing investment decisions. We also present results of the 2017 technology gap prioritization and showcase our current portfolio of technology development projects. To date, 96 COR and 86

  13. Office of Technology Development integrated program for development of in situ remediation technologies

    International Nuclear Information System (INIS)

    Peterson, M.

    1992-08-01

    The Department of Energy's Office of Technology Development has instituted an integrated program focused on development of in situ remediation technologies. The development of in situ remediation technologies will focus on five problem groups: buried waste, contaminated soils, contaminated groundwater, containerized wastes and underground detonation sites. The contaminants that will be included in the development program are volatile and non volatile organics, radionuclides, inorganics and highly explosive materials as well as mixtures of these contaminants. The In Situ Remediation Integrated Program (ISR IP) has defined the fiscal year 1993 research and development technology areas for focusing activities, and they are described in this paper. These R ampersand D topical areas include: nonbiological in situ treatment, in situ bioremediation, electrokinetics, and in situ containment

  14. Characterization, Monitoring, and Sensor Technology Integrated Program (CMST-IP)

    International Nuclear Information System (INIS)

    1994-04-01

    The Characterization, Monitoring, and Sensor Technology Integrated Program seeks to deliver needed technologies, timely and cost-effectively, to the Office of Waste Management (EM-30), the Office of Environmental Restoration (EM-40), and the Office of Facility Transition and Management (EM-60). The scope of characterizations monitoring, and sensor technology needs that are required by those organizations encompass: (1) initial location and characterization of wastes and waste environments - prior to treatment; (2) monitoring of waste retrieval, remediation and treatment processes; (3) characterization of the co-position of final waste treatment forms to evaluate the performance of waste treatments processes; and (4) site closure and compliance monitoring. Wherever possible, the CMST-IP fosters technology transfer and commercialization of technologies that it sponsors

  15. Inducing omnipotence or powerlessness in learners with developmental and attention difficulties through structuring technologies. Accepted for publication in EAI Special Issue (Eds. Eva Brooks)

    DEFF Research Database (Denmark)

    Voldborg, Hanne; Sorensen, Elsebeth Korsgaard

    2017-01-01

    at school? Using this lens, the authors examine, to what extent technology may assist teachers to create more ideal learning environments by reducing the threat for these learners and enable them to participate in learning. Virtual Learning Environments (VLEs), digital templates, timers and calendars......, become aware and understand their own role in the classroom. This paper suggests technologies for structuring and overviewing as basic assistive tools for equalizing the learning possibilities for learners with developmental and attention difficulties in an inclusive school setting....

  16. The effect of adding a home program to weekly institutional-based therapy for children with undefined developmental delay: a pilot randomized clinical trial.

    Science.gov (United States)

    Tang, Mei-Hua; Lin, Chin-Kai; Lin, Wen-Hsien; Chen, Chao-Huei; Tsai, Sen-Wei; Chang, Yin-Yi

    2011-06-01

    Early rehabilitation for children with developmental delay without a defined etiology have included home and clinic programs, but no comparisons have been made and efficacy is uncertain. We compared a weekly visit for institutional-based therapy (IT) to IT plus a structured home activity program (HAP). Seventy children who were diagnosed with motor or global developmental delay (ages 6-48 months and mean developmental age 12.5 months) without defined etiology were recruited (including 45 males and 23 females). The outcomes included the comprehensive developmental inventory for infants and toddlers test and the pediatric evaluation of disability inventory. Children who received only IT improved in developmental level by 2.11 months compared with 3.11 months for those who received a combination of IT and HAP (p = 0.000). On all domains of the comprehensive developmental inventory for infants and toddlers test, except for self-help, children who participated in HAP showed greater improvements, including in cognition (p = 0.015), language (p = 0.010), motor (p = 0.000), and social (p = 0.038) domains. Except on the subdomain of self-care with caregiver assistance, the HAP group showed greater improvement in all the pediatric evaluation of disability inventory subdomains (p < 0.05). Early intervention programs are helpful for these children, and the addition of structured home activity programs may augment the effects on developmental progression. Copyright © 2011. Published by Elsevier B.V.

  17. Genetic, nongenetic and epigenetic risk determinants in developmental programming of type 2 diabetes

    DEFF Research Database (Denmark)

    Vaag, Allan; Brøns, Charlotte; Gillberg, Linn

    2014-01-01

    Low birthweight (LBW) individuals and offspring of women with gestational diabetes mellitus (GDM) exhibit increased risk of developing type 2 diabetes (T2D) and associated cardiometabolic traits in adulthood, which for both groups may be mediated by adverse events and developmental changes in fetal...... factors. Indeed, it has been shown that genetic changes influencing risk of diabetes may also be associated with reduced fetal growth as a result of reduced insulin secretion and/or action. Similarly, increased risk of T2D among offspring could be explained by T2D susceptibility genes shared between...... life. T2D is a multifactorial disease occurring as a result of complicated interplay between genetic and both prenatal and postnatal nongenetic factors, and it remains unknown to what extent the increased risk of T2D associated with LBW or GDM in the mother may be due to, or confounded by, genetic...

  18. 77 FR 73458 - Vehicle Technologies Program; Request for Information

    Science.gov (United States)

    2012-12-10

    ... improving the electronic tools it makes available to assist fleets and consumers in reducing petroleum consumption in vehicles. DOE is seeking partners interested in including customized versions of the electronic...-0049] Vehicle Technologies Program; Request for Information AGENCY: Office of Energy Efficiency and...

  19. Venture Creation Programs: Bridging Entrepreneurship Education and Technology Transfer

    Science.gov (United States)

    Lackéus, Martin; Williams Middleton, Karen

    2015-01-01

    Purpose: The purpose of this paper is to explore how university-based entrepreneurship programs, incorporating real-life venture creation into educational design and delivery, can bridge the gap between entrepreneurship education and technology transfer within the university environment. Design/methodology/approach: Based on a literature review…

  20. 77 FR 46855 - Small Business Technology Transfer Program Policy Directive

    Science.gov (United States)

    2012-08-06

    ... SMALL BUSINESS ADMINISTRATION 13 CFR Chapter I RIN 3245-AF45 Small Business Technology Transfer Program Policy Directive AGENCY: Small Business Administration. ACTION: Final policy directive with request for comments. SUMMARY: The U.S. Small Business Administration (SBA) is amending its Small Business...

  1. Maintaining quality control in a nontraditional nuclear technology degree program

    International Nuclear Information System (INIS)

    DeSain, G.W.

    1989-01-01

    Regents College, created by the Board of Regents of the University of The State on New York in 1971, has been offering, since January 1985, AS and BS degrees in nuclear technology. The impetus for establishing the nuclear technology degrees came from nuclear utility management and had to do with the US Nuclear Regulatory Commission proposed rule regarding degreed operators on shift. There are a variety of ways to earn credits in Regents College degree programs: (1) college courses taken for degree-level credit from regionally accredited colleges; (2) courses sponsored by business, industry, or government that have been evaluated and recommended for credit by the New York National or American Council on Education (ACE's) Program on Noncollegiate Sponsored Instruction (PONSI); (3) military education that has been evaluated by ACE PONSI; (4) approved college-proficiency examinations; and (5) special assessment: an individualized examination of college-level knowledge gained from experience or independent study. Nuclear technology students primarily use college course work, evaluated military education, and proficiency examinations to complete degree programs. However, an increasing number of utilities are having training programs PONSI evaluated, resulting in an increased use of these courses in the nuclear technology degrees. Quality control is a function of several factors described in the paper

  2. Bioenergy Technologies Office Multi-Year Program Plan: July 2014

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-07-09

    This is the May 2014 Update to the Bioenergy Technologies Office Multi-Year Program Plan, which sets forth the goals and structure of the Office. It identifies the research, development, demonstration, and deployment activities the Office will focus on over the next five years and outlines why these activities are important to meeting the energy and sustainability challenges facing the nation.

  3. Information Technology Curriculum Development for Participation and Equity Programs.

    Science.gov (United States)

    Post, Maarten; And Others

    A study explored ways in which training in information technology could be included in Participation and Equity Programs (PEP) in the areas of hospitality/tourism, retailing, and business and finance. The research team conducted a literature search, obtained completed questionnaires from 10 colleges offering a total of 22 PEPs, visited an…

  4. Asnuntuck Community College's Machine Technology Certificate and Degree Programs.

    Science.gov (United States)

    Irlen, Harvey S.; Gulluni, Frank D.

    2002-01-01

    States that although manufacturing remains a viable sector in Connecticut, it is experiencing skills shortages in the workforce. Describes the machine technology program's purpose, the development of the Asnuntuck Community College's (Connecticut) partnership with private sector manufacturers, the curriculum, the outcomes, and benefits of…

  5. Technology spin-offs from the magnetic fusion energy program

    International Nuclear Information System (INIS)

    1982-05-01

    A description is given of 138 possible spin-offs from the magnetic fusion program. The spin-offs cover the following areas: (1) superconducting magnets, (2) materials technology, (3) vacuum systems, (4) high frequency and high power rf, (5) electronics, (6) plasma diagnostics, (7) computers, and (8) particle beams

  6. Developmental programming of long non-coding RNAs during postnatal liver maturation in mice.

    Directory of Open Access Journals (Sweden)

    Lai Peng

    Full Text Available The liver is a vital organ with critical functions in metabolism, protein synthesis, and immune defense. Most of the liver functions are not mature at birth and many changes happen during postnatal liver development. However, it is unclear what changes occur in liver after birth, at what developmental stages they occur, and how the developmental processes are regulated. Long non-coding RNAs (lncRNAs are involved in organ development and cell differentiation. Here, we analyzed the transcriptome of lncRNAs in mouse liver from perinatal (day -2 to adult (day 60 by RNA-Sequencing, with an attempt to understand the role of lncRNAs in liver maturation. We found around 15,000 genes expressed, including about 2,000 lncRNAs. Most lncRNAs were expressed at a lower level than coding RNAs. Both coding RNAs and lncRNAs displayed three major ontogenic patterns: enriched at neonatal, adolescent, or adult stages. Neighboring coding and non-coding RNAs showed the trend to exhibit highly correlated ontogenic expression patterns. Gene ontology (GO analysis revealed that some lncRNAs enriched at neonatal ages have their neighbor protein coding genes also enriched at neonatal ages and associated with cell proliferation, immune activation related processes, tissue organization pathways, and hematopoiesis; other lncRNAs enriched at adolescent ages have their neighbor protein coding genes associated with different metabolic processes. These data reveal significant functional transition during postnatal liver development and imply the potential importance of lncRNAs in liver maturation.

  7. MHD magnet technology development program summary, September 1982

    Energy Technology Data Exchange (ETDEWEB)

    1983-11-01

    The program of MHD magnet technology development conducted for the US Department of Energy by the Massachusetts Institute of Technology during the past five years is summarized. The general strategy is explained, the various parts of the program are described and the results are discussed. Subjects covered include component analysis, research and development aimed at improving the technology base, preparation of reference designs for commercial-scale magnets with associated design evaluations, manufacturability studies and cost estimations, the detail design and procurement of MHD test facility magnets involving transfer of technology to industry, investigations of accessory subsystem characteristics and magnet-flow-train interfacing considerations and the establishment of tentative recommendations for design standards, quality assurance procedures and safety procedures. A systematic approach (framework) developed to aid in the selection of the most suitable commercial-scale magnet designs is presented and the program status as of September 1982 is reported. Recommendations are made for future work needed to complete the design evaluation and selection process and to provide a sound technological base for the detail design and construction of commercial-scale MHD magnets. 85 references.

  8. MHD magnet technology development program summary, September 1982

    International Nuclear Information System (INIS)

    1983-11-01

    The program of MHD magnet technology development conducted for the US Department of Energy by the Massachusetts Institute of Technology during the past five years is summarized. The general strategy is explained, the various parts of the program are described and the results are discussed. Subjects covered include component analysis, research and development aimed at improving the technology base, preparation of reference designs for commercial-scale magnets with associated design evaluations, manufacturability studies and cost estimations, the detail design and procurement of MHD test facility magnets involving transfer of technology to industry, investigations of accessory subsystem characteristics and magnet-flow-train interfacing considerations and the establishment of tentative recommendations for design standards, quality assurance procedures and safety procedures. A systematic approach (framework) developed to aid in the selection of the most suitable commercial-scale magnet designs is presented and the program status as of September 1982 is reported. Recommendations are made for future work needed to complete the design evaluation and selection process and to provide a sound technological base for the detail design and construction of commercial-scale MHD magnets. 85 references

  9. Geothermal technology development program. Annual progress report, October 1980-September 1981

    Energy Technology Data Exchange (ETDEWEB)

    Kelsey, J.R. (ed.)

    1982-09-01

    The status of ongoing Research and Development (R and D) within the Geothermal Technology Development Program is described. The program emphasizes research in rock penetration mechanics, fluid technology, borehole mechanics, and diagnostics technology.

  10. Measurement and monitoring technologies are important SITE program component

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    An ongoing component of the Superfund Innovative Technologies Evaluation (SITE) Program, managed by the US EPA at its Hazardous Waste Engineering Research Laboratory in Cincinnati, is the development and demonstration of new and innovative measurement and monitoring technologies that will be applicable to Superfund site characterization. There are four important roles for monitoring and measurement technologies at Superfund sites: (1) to assess the extent of contamination at a site, (2) to supply data and information to determine impacts to human health and the environment, (3) to supply data to select the appropriate remedial action, and (4) to monitor the success or effectiveness of the selected remedy. The Environmental Monitoring Systems Laboratory in Las Vegas, Nevada (EMSL-LV) has been supporting the development of improved measurement and monitoring techniques in conjunction with the SITE Program with a focus on two areas: Immunoassay for toxic substances and fiber optic sensing for in-situ analysis at Superfund sites

  11. A review of the Technologies Enabling Agile Manufacturing program

    Energy Technology Data Exchange (ETDEWEB)

    Gray, W.H.; Neal, R.E.; Cobb, C.K.

    1996-10-01

    Addressing a technical plan developed in consideration with major US manufacturers, software and hardware providers, and government representatives, the Technologies Enabling Agile Manufacturing (TEAM) program is leveraging the expertise and resources of industry, universities, and federal agencies to develop, integrate, and deploy leap-ahead manufacturing technologies. One of the TEAM program`s goals is to transition products from design to production faster, more efficiently, and at less cost. TEAM`s technology development strategy also provides all participants with early experience in establishing and working within an electronic enterprise that includes access to high-speed networks and high-performance computing and storage systems. The TEAM program uses the cross-cutting tools it collects, develops, and integrates to demonstrate and deploy agile manufacturing capabilities for three high-priority processes identified by industry: material removal, sheet metal forming, electro-mechanical assembly. This paper reviews the current status of the TEAM program with emphasis upon TEAM`s information infrastructure.

  12. ORNL superconducting technology program for electric energy systems

    Science.gov (United States)

    Hawsey, R. A.

    1993-02-01

    The Oak Ridge National Laboratory (ORNL) Superconducting Technology Program is conducted as part of a national effort by the US Department of Energy's (DOE's) Office of Conservation and Renewable Energy to develop the technology base needed by US industry for commercial development of electric power applications of high-temperature superconductivity. The two major elements of this program are wire development and systems development. This document describes the major research and development activities for this program together with related accomplishments. The technical progress reported was summarized from information prepared for the FY-92 Peer Review of Projects, which was conducted by DOE's Office of Program Analysis, Office of Energy Research. This ORNL program is highly leveraged by the staff and other resources of US industry and universities. Interlaboratory teams are also in place on a number of industry-driven projects. Patent disclosures, working group meetings, staff exchanges, and joint publications and presentations ensure that there is technology transfer to US industry. Working together, the collaborative teams are making tremendous progress in solving the scientific and technical issues necessary for the commercialization of long lengths of practical high-temperature superconductor wire and wire products.

  13. ORNL superconducting technology program for electric power systems

    Science.gov (United States)

    Hawsey, R. A.

    1994-04-01

    The Oak Ridge National Laboratory (ORNL) Superconducting Technology Program is conducted as part of a national effort by the US Department of Energy's Office of Energy Efficiency and Renewable Energy to develop the technology base needed by US industry for commercial development of electric power applications of high-temperature superconductivity. The two major elements of this program are conductor development and applications development. This document describes the major research and development activities for this program together with related accomplishments. The technical progress reported was summarized from information prepared for the FY 1993 Annual Program Review held July 28--29, 1993. This ORNL program is highly leveraged by the staff and other resources of US industry and universities. In fact, nearly three-fourths of the ORNL effort is devoted to industrial competitiveness projects with private companies. Interlaboratory teams are also in place on a number of industry-driven projects. Patent disclosures, working group meetings, staff exchanges, and joint publications and presentations ensure that there is technology transfer to US industry. Working together, the collaborative teams are making rapid progress in solving the scientific and technical issues necessary for the commercialization of long lengths of practical high-temperature superconductor wire and wire products.

  14. ISO New England: Results of Ancillary Service Pilot Programs, Alternative Technology Regulation Pilot Program and Demand Response Reserves Pilot Program

    Energy Technology Data Exchange (ETDEWEB)

    Lowell, Jon [ISO New England, Holyoke, MA (United States); Yoshimura, Henry [ISO New England, Holyoke, MA (United States)

    2011-10-26

    This PowerPoint presentation compares performance of pilot program assets and generation resources in alternative technology regulation and demand response reserves for flywheels and residential electric thermal storage.

  15. High-level waste management technology program plan

    International Nuclear Information System (INIS)

    Harmon, H.D.

    1995-01-01

    The purpose of this plan is to document the integrated technology program plan for the Savannah River Site (SRS) High-Level Waste (HLW) Management System. The mission of the SRS HLW System is to receive and store SRS high-level wastes in a see and environmentally sound, and to convert these wastes into forms suitable for final disposal. These final disposal forms are borosilicate glass to be sent to the Federal Repository, Saltstone grout to be disposed of on site, and treated waste water to be released to the environment via a permitted outfall. Thus, the technology development activities described herein are those activities required to enable successful accomplishment of this mission. The technology program is based on specific needs of the SRS HLW System and organized following the systems engineering level 3 functions. Technology needs for each level 3 function are listed as reference, enhancements, and alternatives. Finally, FY-95 funding, deliverables, and schedules are s in Chapter IV with details on the specific tasks that are funded in FY-95 provided in Appendix A. The information in this report represents the vision of activities as defined at the beginning of the fiscal year. Depending on emergent issues, funding changes, and other factors, programs and milestones may be adjusted during the fiscal year. The FY-95 SRS HLW technology program strongly emphasizes startup support for the Defense Waste Processing Facility and In-Tank Precipitation. Closure of technical issues associated with these operations has been given highest priority. Consequently, efforts on longer term enhancements and alternatives are receiving minimal funding. However, High-Level Waste Management is committed to participation in the national Radioactive Waste Tank Remediation Technology Focus Area. 4 refs., 5 figs., 9 tabs

  16. High-level waste management technology program plan

    Energy Technology Data Exchange (ETDEWEB)

    Harmon, H.D.

    1995-01-01

    The purpose of this plan is to document the integrated technology program plan for the Savannah River Site (SRS) High-Level Waste (HLW) Management System. The mission of the SRS HLW System is to receive and store SRS high-level wastes in a see and environmentally sound, and to convert these wastes into forms suitable for final disposal. These final disposal forms are borosilicate glass to be sent to the Federal Repository, Saltstone grout to be disposed of on site, and treated waste water to be released to the environment via a permitted outfall. Thus, the technology development activities described herein are those activities required to enable successful accomplishment of this mission. The technology program is based on specific needs of the SRS HLW System and organized following the systems engineering level 3 functions. Technology needs for each level 3 function are listed as reference, enhancements, and alternatives. Finally, FY-95 funding, deliverables, and schedules are s in Chapter IV with details on the specific tasks that are funded in FY-95 provided in Appendix A. The information in this report represents the vision of activities as defined at the beginning of the fiscal year. Depending on emergent issues, funding changes, and other factors, programs and milestones may be adjusted during the fiscal year. The FY-95 SRS HLW technology program strongly emphasizes startup support for the Defense Waste Processing Facility and In-Tank Precipitation. Closure of technical issues associated with these operations has been given highest priority. Consequently, efforts on longer term enhancements and alternatives are receiving minimal funding. However, High-Level Waste Management is committed to participation in the national Radioactive Waste Tank Remediation Technology Focus Area. 4 refs., 5 figs., 9 tabs.

  17. Mentor Age and Youth Developmental Outcomes in School-Based Mentoring Programs

    Science.gov (United States)

    Hwang, NaYoung

    2015-01-01

    Mentoring programs that provide guidance and support for disadvantaged youth have expanded rapidly during the past decade in the United States. Research suggests that students with teenage mentors exhibit positive youth development, including enhanced academic self-esteem and connectedness. By contrast, some studies showed that programs that offer…

  18. Mixed Waste Integrated Program -- Problem-oriented technology development

    International Nuclear Information System (INIS)

    Hart, P.W.; Wolf, S.W.; Berry, J.B.

    1994-01-01

    The Mixed Waste Integrated Program (MWIP) is responding to the need for DOE mixed waste treatment technologies that meet these dual regulatory requirements. MWIP is developing emerging and innovative treatment technologies to determine process feasibility. Technology demonstrations will be used to determine whether processes are superior to existing technologies in reducing risk, minimizing life-cycle cost, and improving process performance. Technology development is ongoing in technical areas required to process mixed waste: materials handling, chemical/physical treatment, waste destruction, off-gas treatment, final forms, and process monitoring/control. MWIP is currently developing a suite of technologies to process heterogeneous waste. One robust process is the fixed-hearth plasma-arc process that is being developed to treat a wide variety of contaminated materials with minimal characterization. Additional processes encompass steam reforming, including treatment of waste under the debris rule. Advanced off-gas systems are also being developed. Vitrification technologies are being demonstrated for the treatment of homogeneous wastes such as incinerator ash and sludge. An alternative to conventional evaporation for liquid removal--freeze crystallization--is being investigated. Since mercury is present in numerous waste streams, mercury removal technologies are being developed

  19. Environmental restoration and waste management: Robotics technology development program: Robotics 5-year program plan

    International Nuclear Information System (INIS)

    1991-01-01

    This plan covers robotics Research, Development, Demonstration, Testing, activities in the Program for the next five years. These activities range from bench-scale R ampersand D to fullscale hot demonstrations at DOE sites. This plan outlines applications of existing technology to near-term needs, the development and application of enhanced technology for longer-term needs, and an initiation of advanced technology development to meet those needs beyond the five-year plan. The objective of the Robotic Technology Development (RTDP) is to develop and apply robotics technologies that will enable Environmental Restoration and Waste Management operations at DOE sites to be safer, faster and cheaper. Five priority DOE sites were visited in March 1990 to identify needs for robotics technology in ER ampersand WM operations. This 5-Year Program Plan for the RTDP detailed annual plans for robotics technology development based on identified needs. This 5-Year Program Plan discusses the overall approach to be adopted by the RTDP to aggressively develop robotics technology and contains discussions of the Program Management Plan, Site Visit and Needs Summary, Approach to Needs-Directed Technical Development, Application-Specific Technical Development, and Cross-Cutting and Advanced Technology. Integrating application-specific ER ampersand WM needs, the current state of robotics technology, and the potential benefits (in terms of faster, safer, and cheaper) of new technology, the Plan develops application-specific road maps for robotics RDDT ampersand E for the period FY 1991 through FY 1995. In addition, the Plan identifies areas where longer-term research in robotics will have a high payoff in the 5- to 20-year time frame. 12 figs

  20. Clean Coal Technology Demonstration Program: Program update 1991 (as of December 31, 1991)

    International Nuclear Information System (INIS)

    1992-02-01

    The Clean Coal Technology Demonstration Program (also referred to as the CCT Program) is a government and industry cofunded technology development effort to demonstrate a new generation of innovative coal utilization processes in a series of large-scale ''showcase'' facilities built across the country. The program takes the most promising advanced coal-based technologies and moves them into the commercial marketplace through demonstration. These demonstrations are on a scale large enough to generate all the data, from design, construction and operation, that are necessary for the private sector to judge commercial potential and make informed, confident decisions on commercial readiness. The CCT Program has been identified in the National Energy Strategy as major initiative supporting the strategy's overall goals to: increase efficiency of energy use; secure future energy supplies; enhance environmental quality; fortify foundations. The technologies being demonstrated under the CCT Program when commercially available will enable coal to reach its full potential as a source of energy for the nation and the international marketplace. The goal of the program is to furnish the US and international energy marketplaces with a number of advanced, highly efficient, and environmentally acceptable coal-using technologies

  1. EPA [Environmental Protection Agency] SITE [Superfund Innovative Technology Evaluation] program seeks technology proposals

    International Nuclear Information System (INIS)

    Anon.

    1989-01-01

    EPA will issue an RFP to initiate the SITE-005 solicitation for demonstration of technologies under the Superfund Innovative Technology Evaluation (SITE) Program. This portion of the SITE program offers a mechanism for conducting a joint technology demonstration between EPA and the private sector. The goal of the demonstration program is to provide an opportunity for developers to demonstrate the performance of their technologies on actual hazardous wastes at Superfund sites, and to provide accurate and reliable data on that performance. Technologies selected must be of commercial scale and provide solutions to problems encountered at Superfund Sites. Primary emphasis in the RFP is on technologies that address: treatment of mixed, low level radioactive wastes in soils and groundwater; treatment of soils and sludges contaminated with organics and/or inorganics, materials handling as a preliminary step to treatment or further processing, treatment trains designed to handle specific wastes, are in situ technologies, especially those processes providing alternatives to conventional groundwater pump and treat techniques

  2. The relationship of fluidized bed technology to the U.S. Clean Coal Technology demonstration program

    International Nuclear Information System (INIS)

    Weth, G.; Geffken, J.; Huber, D.A.

    1991-01-01

    Fluidized Bed Combustion projects (both AFBCs and PFBCs) have a prominent role in the US DOE Clean Coal Technology (CCT) Program. This program has the successful commercialization of these technologies as its primary objective and this is the basic criterion for government funding and participation in the development and demonstration of the technologies. Under the CCT program the US DOE is actively involved in the development and operation of three Fluidized Bed Technology projects, NUCLA, TIDD, and SPORN, and is in the negotiation stage on others, Dairyland, Nichols and Tallahassee. All of these projects, along with the operating information on fluidized beds in the industrial sector, will provide a basis for evaluating future utilization of Fluidized Bed Technology in the market place. Impacting upon further utilization will be the time-frame and the Clean Air Act Amendments of 1990. This paper presents the results of a study to ascertain the commercial readiness of Fluidized Bed Technology to meet the emissions and time-frame requirements of the Clean Air Act Amendments of 1990. Specifically addressed are: Commercialization criteria/factors which candidate and/or existing CCTs must achieve in order to gain market acceptance. The status of Fluidized Bed Technology in achieving these commercialization criteria for market acceptance (industrial and utility) consistent with the time frame of the Clean Air Act Amendments of 1990. Recommendations of commercialization criteria for future fluidized bed CCT demonstration projects

  3. 1992 update of US EPA's Superfund Innovative Technology Evaluation (SITE) Emerging Technology Program

    International Nuclear Information System (INIS)

    Lewis, N.M.; Barkley, N.P.; Williams, T.

    1992-01-01

    The Superfund Innovative Technology Evaluation (SITE) Emerging Technology Program (ETP) has financially supported further development of bench- and pilot-scale testing and evaluation of innovative technologies for use at hazardous waste sites for five years. The ETP was established under the Superfund Amendments and Reauthorization Act (SARA) of 1986. The ETP complies with the goal of the SITE Program to promote, accelerate and make commercially available the development of alternative/innovative treatment technologies for use at Superfund sites. Technologies are submitted to the ETP through yearly solicitations for Preproposals. Applicants are asked to submit a detailed project proposal and a cooperative agreement application that requires Developer/EPA cost sharing. EPA co-funds selected Developers for one to two years. Second-year funding requires documentation of significant progress during the first year. Facilities, equipment, data collection, performance and development are monitored throughout the project. The US Department of Energy (DOE) and the US Air Force (USAF) are participants in the ETP. DOE has co-funded ETP projects since 1990 and the USAF since 1991. A goal of the ETP is to move developed technologies to the field-demonstration stage. A developer may be considered for participation in the SITE Demonstration Program if performance in the ETP indicates the technology is field-ready for evaluation. Six technology categories: biological, chemical, materials handling, physical, solidification/stabilization and thermal, are presently in the ETP. Technologies of primary interest to EPA are those that can treat complex mixtures of hazardous organic and inorganic contaminants and provide improved solids handling and/or pretreatment. An account of the background and progress of the ETP's first five years is presented in this paper. Technologies currently in the ETP are noted, and developers and EPA Project Managers, are listed. 4 refs., 11 figs., 6 tabs

  4. Video Games to Augment Leisure Programming in a State Hospital Residence for Developmentally Disabled Clients.

    Science.gov (United States)

    Powers, Janet; Ball, Thomas S.

    1983-01-01

    Three mildly and moderately retarded, physically handicapped institutionalized men (17-30 years old) successfully participated in a recreation program involving adapted videogames. Doubles play fostered cooperative social interaction between players. (CL)

  5. Role of the Hypothalamic-Pituitary-Adrenal Axis in Developmental Programming of Health and Disease

    Science.gov (United States)

    Xiong, Fuxia; Zhang, Lubo

    2012-01-01

    Adverse environments during the fetal and neonatal development period may permanently program physiology and metabolism, and lead to increased risk of diseases in later life. Programming of the hypothalamic-pituitary-adrenal (HPA) axis is one of the key mechanisms that contribute to altered metabolism and response to stress. Programming of the HPA axis often involves epigenetic modification of the glucocorticoid receptor (GR) gene promoter, which influences tissue-specific GR expression patterns and response to stimuli. This review summarizes the current state of research on the HPA axis and programming of health and disease in the adult, focusing on the epigenetic regulation of GR gene expression patterns in response to fetal and neonatal stress. Aberrant GR gene expression patterns in the developing brain may have a significant negative impact on protection of the immature brain against hypoxic-ischemic encephalopathy in the critical period of development during and immediately after birth. PMID:23200813

  6. Technology readiness levels and technology status for selected long term/high payoff technologies on the RLV program

    Science.gov (United States)

    Rosmait, Russell L.

    1996-01-01

    The development of a new space transportation system in a climate of constant budget cuts and staff reductions can be and is a difficult task. It is no secret that NASA's current launching system consumes a very large portion of NASA funding and requires a large army of people to operate & maintain the system. The new Reusable Launch Vehicle (RLV) project and it's programs are faced with a monumental task of making the cost of access to space dramatically lower and more efficient than NASA's current system. With pressures from congressional budget cutters and also increased competition and loss of market share from international agencies RLV's first priority is to develop a 'low-cost, reliable transportation to earth orbit.' One of the RLV's major focus in achieving low-cost, reliable transportation to earth orbit is to rely on the maturing of advanced technologies. The technologies for the RLV are numerous and varied. Trying to assess their current status, within the RLV development program is paramount. There are several ways to assess these technologies. One way is through the use of Technology Readiness Levels (TRL's). This project focused on establishing current (summer 95) 'worst case' TRL's for six selected technologies that are under consideration for use within the RLV program. The six technologies evaluated were Concurrent Engineering, Embedded Sensor Technology, Rapid Prototyping, Friction Stir Welding, Thermal Spray Coatings, and VPPA Welding.

  7. Mississippi Curriculum Framework for Banking & Finance Technology (Program CIP: 52.0803--Banking and Related Financial Programs, Other). Postsecondary Programs.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the banking and finance technology program. Presented in the introduction are a program description and suggested course sequence. Section I is a curriculum guide consisting of outlines for…

  8. Overview: Defense high-level waste technology program

    International Nuclear Information System (INIS)

    Shupe, M.W.; Turner, D.A.

    1987-01-01

    Defense high-level waste generated by atomic energy defense activities is stored on an interim basis at three U.S. Department of Energy (DOE) operating locations; the Savannah River Plant in South Carolina, the Hanford Site in Washington, and the Idaho National Engineering Laboratory in Idaho. Responsibility for the permanent disposal of this waste resides with DOE's Office of Defense Waste and Transportation Management. The objective of the Defense High-Level Wast Technology Program is to develop the technology for ending interim storage and achieving permanent disposal of all U.S. defense high-level waste. New and readily retrievable high-level waste are immobilized for disposal in a geologic repository. Other high-level waste will be stabilized in-place if, after completion of the National Environmental Policy Act (NEPA) process, it is determined, on a site-specific basis, that this option is safe, cost effective and environmentally sound. The immediate program focus is on implementing the waste disposal strategy selected in compliance with the NEPA process at Savannah River, while continuing progress toward development of final waste disposal strategies at Hanford and Idaho. This paper presents an overview of the technology development program which supports these waste management activities and an assessment of the impact that recent and anticipated legal and institutional developments are expected to have on the program

  9. Augmenting Space Technology Program Management with Secure Cloud & Mobile Services

    Science.gov (United States)

    Hodson, Robert F.; Munk, Christopher; Helble, Adelle; Press, Martin T.; George, Cory; Johnson, David

    2017-01-01

    The National Aeronautics and Space Administration (NASA) Game Changing Development (GCD) program manages technology projects across all NASA centers and reports to NASA headquarters regularly on progress. Program stakeholders expect an up-to-date, accurate status and often have questions about the program's portfolio that requires a timely response. Historically, reporting, data collection, and analysis were done with manual processes that were inefficient and prone to error. To address these issues, GCD set out to develop a new business automation solution. In doing this, the program wanted to leverage the latest information technology platforms and decided to utilize traditional systems along with new cloud-based web services and gaming technology for a novel and interactive user environment. The team also set out to develop a mobile solution for anytime information access. This paper discusses a solution to these challenging goals and how the GCD team succeeded in developing and deploying such a system. The architecture and approach taken has proven to be effective and robust and can serve as a model for others looking to develop secure interactive mobile business solutions for government or enterprise business automation.

  10. Dissemination of Technology to Evaluate Healthy Food Incentive Programs.

    Science.gov (United States)

    Freedman, Darcy A; Hunt, Alan R; Merritt, Katie; Shon, En-Jung; Pike, Stephanie N

    2017-03-01

    Federal policy supports increased implementation of monetary incentive interventions for chronic disease prevention among low-income populations. This study describes how a Prevention Research Center, working with a dissemination partner, developed and distributed technology to support nationwide implementation and evaluation of healthy food incentive programming focused on Supplemental Nutrition Assistance Program recipients. FM Tracks, an iOS-based application and website, was developed to standardize evaluation methods for healthy food incentive program implementation at direct-to-consumer markets. This evaluation examined diffusion and adoption of the technology over 9 months (July 2015-March 2016). Data were analyzed in 2016. FM Tracks was disseminated to 273 markets affiliated with 37 regional networks in 18 states and Washington, DC. All markets adopted the sales transaction data collection feature, with nearly all recording at least one Supplemental Nutrition Assistance Program (99.3%) and healthy food incentive (97.1%) transaction. A total of 43,493 sales transactions were recorded. By the ninth month of technology dissemination, markets were entering individual sales transactions using the application (34.5%) and website (29.9%) and aggregated transactions via website (35.6%) at similar rates. Use of optional evaluation features like recording a customer ID with individual transactions increased successively with a low of 22.2% during the first month to a high of 69.2% in the ninth month. Systematic and widely used evaluation technology creates possibilities for pragmatic research embedded within ongoing, real-world implementation of food access interventions. Technology dissemination requires supportive technical assistance and continuous refinement that can be advanced through academic-practitioner partnerships. Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  11. Developing an Astronomy Program at the Crownpoint Institute of Technology

    Science.gov (United States)

    Gino, M. C.

    2004-12-01

    The Crownpoint Institute of Technology (CIT) is a tribal college located on the eastern edge of the Navajo Nation in northwestern New Mexico. Historically CIT is a technical college which grants AAS degrees and certificates in a number of vocational and technical fields. CIT is in the process of seeking higher learning articulation and accreditation, and has received "Candidacy Status" from the North Central Association of Colleges and Schools Commission on Institutions of Higher Education. To meet the demands placed upon the college as it steps into its role as an institution of higher learning, CIT is dedicated to broadening its curriculum with programs that encourage math, science and technology, and to increasing the number of courses that advance knowledge in both Navajo and Western society by enhancing both laboratory and educational technologies. The introduction of astronomy into the science curriculum advances CIT's goals in all of these areas, and presents a unique opportunity to incorporate traditional Navajo scientific knowledge into a technically advanced science program. In this poster we outline the development of the astronomy program, which has started with the inclusion of the first astronomy course into the science curriculum and the acquisition of two small telescope systems for K-14 student use and public outreach, and will continue through the construction of a campus observatory capable of supporting an undergraduate research program. It is our expectation that through the introduction of astronomy into the curriculum, CIT will advance its goals of increasing science and technology educational opportunities for its students and training the next generation of Navajo science and technology professionals, while maintaining an awareness of the needs of the Navajo Nation and a sensitivity to Navajo cultural values and protocols.

  12. Office of Industrial Technologies: Summary of program results

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-01-01

    Working in partnership with industry, the US Department of Energy`s (DOE`s) Office of Industrial Technologies (OIT) is helping reduce industrial energy use, emissions, and waste while boosting productivity. Operating within the Office of Energy Efficiency and Renewable Energy (EE), OIT conducts research, development, demonstration, and technology transfer efforts that are producing substantial, measurable benefits to industry. This document summarizes some of the impacts of OIT`s programs through 1997. OIT tracks energy savings as well as other benefits associated with the successfully commercialized technologies resulting from OIT-supported research partnerships. Specifically, a chart shows current and cumulative energy savings as well as cumulative reductions of various air pollutants including particulates, volatile organic compounds (VOCs), nitrogen oxides (NO{sub x}), sulfur oxides (SO{sub x}), and the greenhouse gas, carbon dioxide (CO{sub 2}). The bulk of the document consists of four appendices. Appendix 1 describes the technologies currently available commercially, along with their applications and benefits; Appendix 2 describes the OIT-supported emerging technologies that are likely to be commercialized within the next year or two; Appendix 3 describes OIT-sponsored technologies used in commercial applications in the past that are no longer tracked; and Appendix 4 describes the methodology used to assess and track OIT-supported technologies.

  13. Benefits and costs of integrating technology into undergraduate nursing programs.

    Science.gov (United States)

    Glasgow, Mary Ellen Smith; Cornelius, Frances H

    2005-01-01

    Advances in technology over the last decade have resulted in increased opportunities for educators to become more innovative in classroom and clinical teaching. These innovations have allowed students and faculty to access essential clinical information at the point of care/need. By capitalizing on technologies such as personal digital assistants and course delivery shells, faculty and students have both portable and remote access to information that can guide practice and learning activities in clinical, classroom, and distance settings. For instance, a student can use a personal digital assistant to research a patient's new medication at the bedside, study course information, access references during class in response to a question, or download clinical materials from home. Although the benefits of having ready access to information seem obvious, there are costs and strategic planning activities associated with implementing these projects. Clearly, the objective of any academic nursing program is to develop skills among students so they can efficiently access information and use that information to guide their nursing practice. To do so, academic nursing administrators must have the forethought to envision how new technologies can support achieving this goal as well as the ability to put in place the infrastructure supports needed for success. This article presents a case study of how one institution developed the necessary infrastructure and garnished the appropriate resources to implement an ambitious technology initiative integrated throughout a large undergraduate nursing program. In addition, how the integration of technology, online and mobile, can enhance clinical learning will be discussed.

  14. Heavy-section steel technology program: Fracture issues

    International Nuclear Information System (INIS)

    Pennell, W.E.

    1992-01-01

    Large-scale fracture mechanics tests have resulted in the identification of a number of fracture technology issues. Identification of additional issues has come from the reactor vessel materials irradiation test program and from reactor operating experience. This paper provides a review of fracture issues with an emphasis on their potential impact on a reactor vessel pressurized thermal shock (PTS) analysis. Mixed mode crack propagation emerges as a major issue, due in large measure to the poor performance of existing models for the prediction of ductile tearing. Rectification of ductile tearing technology deficiencies may require extending the technology to include a more complete treatment of stress state and loading history effects. The effect of cladding on vessel fracture remains uncertain to the point that it is not possible to determine at this time if the net effect will be positive or negative. Enhanced fracture toughness for shallow flaws has been demonstrated for low-strength structural steels. Demonstration of a similar effect in reactor pressure vessel steels could have a significant beneficial effect on the probabilistic analysis of reactor vessel fracture. Further development of existing fracture mechanics models and concepts is required to meet the special requirements for fracture evaluation of circumferential flaws in the welds of ring-forged vessels. Fracture technology advances required to address the issues discussed in this paper are the major objective for the ongoing Heavy Section Steel Technology (HSST) program at ORNL

  15. Heavy-Section Steel Technology program fracture issues

    International Nuclear Information System (INIS)

    Pennell, W.E.

    1989-10-01

    Large scale fracture mechanics tests have resulted in the identification of a number of fracture technology issues. Identification of additional issues has come from the reactor vessel materials irradiation test program and from reactor operating experience. This paper provides a review of fracture issues with an emphasis on their potential impact on a reactor vessel pressurized thermal shock (PTS) analysis. Mixed mode crack propagation emerges as a major issue, due in large measure to the poor performance of existing models for the prediction of ductile tearing. Rectification of ductile tearing technology deficiencies may require extending the technology to include a more complete treatment of stress state and loading history effects. The effect of cladding on vessel fracture remains uncertain to the point that it is not possible to determine at this time if the net effect will be positive or negative. Enhanced fracture toughness for shallow flaws has been demonstrated for low strength structural steels. Demonstration of a similar effect in reactor pressure vessel steels could have a significant beneficial effect on the probabilistic analysis of reactor vessel fracture. Further development of existing fracture mechanics models and concepts is required to meet the special requirements for fracture evaluation of circumferential flaws in the welds of ring forged vessels. Fracture technology advances required to address the issues discussed in this paper are the major objective for the ongoing Heavy Section Steel Technology (HSST) program at ORNL. 24 refs., 18 figs

  16. Movement-to-music computer technology: a developmental play experience for children with severe physical disabilities.

    Science.gov (United States)

    Tam, Cynthia; Schwellnus, Heidi; Eaton, Ceilidh; Hamdani, Yani; Lamont, Andrea; Chau, Tom

    2007-01-01

    Children with severe physical disabilities often lack the physical skills to explore their environment independently, and to play with toys or musical instruments. The movement-to-music (MTM) system is an affordable computer system that allows children with limited movements to play and create music. The present study explored parents' experiences of using the MTM system with their children. A qualitative methodology employing in-depth interview techniques was used with six mothers and their children. The themes extracted from the data were organized under two main concepts of the International Classification of Functioning, Disability, and Health (ICF) (WHO, 2001) framework. The results showed that the MTM expanded horizons for the child along the ICF health dimensions and the MTM had a positive impact on ICF environmental determinants of health. The small sample size should be noted as a limitation of this study. Further research should be carried out with a larger sample of children with restricted mobility to obtain a better understanding of the impact of MTM technology on children's psychosocial development.

  17. Assistive technology needs, functional difficulties, and services utilization and coordination of children with developmental disabilities in the United States.

    Science.gov (United States)

    Lin, Sue C; Gold, Robert S

    2018-01-01

    Assistive technology (AT) enhances the ability of individuals with disabilities to be fully engaged in activities at home, at school, and within their communities-especially for children with developmental disabilities (DD) with physical, sensory, learning, and/or communication impairments. The prevalence of children with DD in the United States has risen from 12.84% in 1997 to 15.04% in 2008. Thus, it is important to monitor the status of their AT needs, functional difficulties, services utilization, and coordination. Using data from the 2009-2010 National Survey on Children with Special Health Care Needs (NS-CSHCN), we conducted bivariate and multivariate statistical analysis, which found that 90% or more of parents of both children with DD and other CSHCN reported that their child's AT needs were met for vision, hearing, mobility, communication, and durable medical equipment; furthermore, children with DD had lower odds of AT needs met for vision and hearing and increased odds for meeting AT needs in mobility and communication. Our findings outline the current AT needs of children with DD nationally. Fulfilling these needs has the potential to engender positive lifelong effects on the child's disabilities, sense of independence, self-confidence, and productivity.

  18. Tritium tasks for the net fusion technology program

    International Nuclear Information System (INIS)

    Hircq, B.

    1990-01-01

    Six Tritium Technology tasks have been undertaken in the BRUYERES-LE-CHATEL Research Center of the French Atomic Energy Commission, in June 1986, as part of the NET Tritium Technology Program. Four of these six studies concern the torus exhaust gas purification and two of them are more specific of the involved materials. In 1988, the studies themselves have begun and the objective of this document is to indicate, for each task, the main results which have been obtained during the period 1988-89, for allowing a global valuation of the progress state as well as an anticipation for carrying out the works

  19. Energy from Biomass Research and Technology Transfer Program

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, Dorin

    2015-12-31

    The purpose of CPBR is to foster and facilitate research that will lead to commercial applications. The goals of CPBR’s Energy from Biomass Research and Technology Transfer Program are to bring together industry, academe, and federal resources to conduct research in plant biotechnology and other bio-based technologies and to facilitate the commercialization of the research results to: (1) improve the utilization of plants as energy sources; (2) reduce the cost of renewable energy production; (3) facilitate the replacement of petroleum by plant-based materials; (4) create an energy supply that is safer in its effect on the environment, and (5) contribute to U.S. energy independence.

  20. Accelerator technology program. Status report, October 1984-March 1985

    International Nuclear Information System (INIS)

    Jameson, R.A.; Schriber, S.O.

    1986-04-01

    Activities of the racetrack-microtron development programs are highlighted, one of which is being done in collaboration with the National Bureau of Standards and the other with the University of Illinois; the BEAR (Beam Experiment Aboard Rocket) project; work in beam dynamics; the proposed LAMPF II accelerator; and the Proton Storage Ring. Discussed next is radio-frequency and microwave technology, followed by activities in accelerator theory and simulation, and free-electron laser technology. The report concludes with a listing of papers published during this reporting period

  1. Cast Metals Coalition Technology Transfer and Program Management Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Gwyn, Mike

    2009-03-31

    The Cast Metals Coalition (CMC) partnership program was funded to ensure that the results of the Department of Energy's (DOE) metalcasting research and development (R&D) projects are successfully deployed into industry. Specifically, the CMC program coordinated the transfer and deployment of energy saving technologies and process improvements developed under separately funded DOE programs and projects into industry. The transition of these technologies and process improvements is a critical step in the path to realizing actual energy savings. At full deployment, DOE funded metalcasting R&D results are projected to save 55% of the energy used by the industry in 1998. This closely aligns with DOE's current goal of driving a 25% reduction in industrial energy intensity by 2017. In addition to benefiting DOE, these energy savings provide metalcasters with a significant economic advantage. Deployment of already completed R&D project results and those still underway is estimated to return over 500% of the original DOE and industry investment. Energy savings estimates through December 2008 from the Energy-Saving Melting and Revert Reduction Technology (E-SMARRT) portfolio of projects alone are 12 x 1012 BTUs, with a projection of over 50 x 1012 BTUs ten years after program completion. These energy savings and process improvements have been made possible through the unique collaborative structure of the CMC partnership. The CMC team consists of DOE's Office of Industrial Technology, the three leading metalcasting technical societies in the U.S: the American Foundry Society; the North American Die Casting Association; and the Steel Founders Society of America; and the Advanced Technology Institute (ATI), a recognized leader in distributed technology management. CMC provides collaborative leadership to a complex industry composed of approximately 2,100 companies, 80% of which employ less than 100 people, and only 4% of which employ more than 250 people

  2. Developmental cascade effects of the New Beginnings Program on adolescent adaptation outcomes.

    Science.gov (United States)

    McClain, Darya Bonds; Wolchik, Sharlene A; Winslow, Emily; Tein, Jenn-Yun; Sandler, Irwin N; Millsap, Roger E

    2010-11-01

    Using data from a 6-year longitudinal follow-up sample of 240 youth who participated in a randomized experimental trial of a preventive intervention for divorced families with children ages 9-12, the current study tested alternative cascading pathways by which the intervention decreased symptoms of internalizing disorders, symptoms of externalizing disorders, substance use, and risky sexual behavior and increased self-esteem and academic performance in mid- to late adolescence (15-19 years old). It was hypothesized that the impact of the program on adolescent adaptation outcomes would be explained by progressive associations between program-induced changes in parenting and youth adaptation outcomes. The results supported a cascading model of program effects in which the program was related to increased mother-child relationship quality that was related to subsequent decreases in child internalizing problems, which then was related to subsequent increases in self-esteem and decreases in symptoms of internalizing disorders in adolescence. The results were also consistent with a model in which the program increased maternal effective discipline that was related to decreased child externalizing problems, which was related to subsequent decreases in symptoms of externalizing disorders, less substance use, and better academic performance in adolescence. There were no significant differences in the model based on level of baseline risk or adolescent gender. These results provide support for a cascading pathways model of child and adolescent development.

  3. The U.S. program for fusion nuclear technology development

    International Nuclear Information System (INIS)

    Clarke, J.F.; Haas, G.M.

    1989-01-01

    The Fusion Nuclear Technology (FNT) research and development program in the United States is shaped by a hierarchy of documents and by the environment for nuclear energy existing in the United States. The fission nuclear industry in the United States has suffered problems with public perception of safety, waste disposal issues, and economics as influenced by safety and environmental issues. For fusion to be a viable energy alternative, it must offer significant improvements in these areas. The hierarchy of documents defining objectives, plans, and strategy of the U.S. FNT program consists of the Magnetic Fusion Program Plan (MFPP) (February 1985), the Technical Planning Activity Final Report (January 1987), the Finesse Program Report (January 1987), and the Blanket Comparison and Selection Study Final Report (September 1984). In addition, two other documents are also significant in shaping FNT policy. These are the IEA report on Material for Fusion (December 1986) and the Summary of the Report of the Senior Committee on Environmental, Safety, and Economic Aspects of Magnetic Fusion Energy (September 1987). The U.S. Magnetic Fusion Program Plan defines four key technical issues (magnetic confinement systems, properties of burning plasmas, fusion nuclear technology, and fusion materials). (orig./KP)

  4. Pollution technology program, can-annular combustor engines

    Science.gov (United States)

    Roberts, R.; Fiorentino, A. J.; Greene, W.

    1976-01-01

    A Pollution Reduction Technology Program to develop and demonstrate the combustor technology necessary to reduce exhaust emissions for aircraft engines using can-annular combustors is described. The program consisted of design, fabrication, experimental rig testing and assessment of results and was conducted in three program elements. The combustor configurations of each program element represented increasing potential for meeting the 1979 Environmental Protection Agency (EPA) emission standards, while also representing increasing complexity and difficulty of development and adaptation to an operational engine. Experimental test rig results indicate that significant reductions were made to the emission levels of the baseline JT8D-17 combustor by concepts in all three program elements. One of the Element I single-stage combustors reduced carbon monoxide to a level near, and total unburned hydrocarbons (THC) and smoke to levels below the 1979 EPA standards with little or no improvement in oxides of nitrogen. The Element II two-stage advanced Vorbix (vortex burning and mixing) concept met the standard for THC and achieved significant reductions in CO and NOx relative to the baseline. Although the Element III prevaporized-premixed concept reduced high power NOx below the Element II results, there was no improvement to the integrated EPA parameter relative to the Vorbix combustor.

  5. Developmental programming: deficits in reproductive hormone dynamics and ovulatory outcomes in prenatal, testosterone-treated sheep.

    Science.gov (United States)

    Veiga-Lopez, A; Ye, W; Phillips, D J; Herkimer, C; Knight, P G; Padmanabhan, V

    2008-04-01

    Prenatal testosterone excess leads to neuroendocrine, ovarian, and metabolic disruptions, culminating in reproductive phenotypes mimicking that of women with polycystic ovary syndrome (PCOS). The objective of this study was to determine the consequences of prenatal testosterone treatment on periovulatory hormonal dynamics and ovulatory outcomes. To generate prenatal testosterone-treated females, pregnant sheep were injected intramuscularly (days 30-90 of gestation, term=147 days) with 100 mg of testosterone-propionate in cottonseed oil semi-weekly. Female offspring born to untreated control females and prenatal testosterone-treated females were then studied during their first two breeding seasons. Sheep were given two injections of prostaglandin F2alpha 11 days apart, and blood samples were collected at 2-h intervals for 120 h, 10-min intervals for 8 h during the luteal phase (first breeding season only), and daily for an additional 15 days to characterize changes in reproductive hormonal dynamics. During the first breeding season, prenatal testosterone-treated females manifested disruptions in the timing and magnitude of primary gonadotropin surges, luteal defects, and reduced responsiveness to progesterone negative feedback. Disruptions in the periovulatory sequence of events during the second breeding season included: 1) delayed but increased preovulatory estradiol rise, 2) delayed and severely reduced primary gonadotropin surge in prenatal testosterone-treated females having an LH surge, 3) tendency for an amplified secondary FSH surge and a shift in the relative balance of FSH regulatory proteins, and 4) luteal responses that ranged from normal to anovulatory. These outcomes are likely to be of relevance to developmental origin of infertility disorders and suggest that differences in fetal exposure or fetal susceptibility to testosterone may account for the variability in reproductive phenotypes.

  6. The expression of petunia strigolactone pathway genes is altered as part of the endogenous developmental program

    Directory of Open Access Journals (Sweden)

    Revel S M Drummond

    2012-01-01

    Full Text Available Analysis of mutants with increased branching has revealed the strigolactone synthesis/perception pathway which regulates branching in plants. However, whether variation in this well conserved developmental signalling system contributes to the unique plant architectures of different species is yet to be determined. We examined petunia orthologues of the Arabidopsis MAX1 and MAX2 genes to characterise their role in petunia architecture. A single orthologue of MAX1, PhMAX1 which encodes a cytochrome P450, was identified and was able to complement the max1 mutant of Arabidopsis. Petunia has two copies of the MAX2 gene, PhMAX2A and PhMAX2B which encode F-Box proteins. Differences in the transcript levels of these two MAX2-like genes suggest diverging functions. Unlike PhMAX2B, PhMAX2A mRNA levels increase as leaves age. Nonetheless, this gene functionally complements the Arabidopsis max2 mutant indicating that the biochemical activity of the PhMAX2A protein is not significantly different from MAX2. The expression of the petunia strigolactone pathway genes (PhCCD7, PhCCD8, PhMAX1, PhMAX2A, and PhMAX2B was then further investigated throughout the development of wild-type petunia plants. Three of these genes showed changes in mRNA levels over the development series. Alterations to the expression of these genes over time, or in different regions of the plant, may influence the branching growth habit of the plant. Alterations to strigolactone production and/or sensitivity could allow both subtle and dramatic changes to branching within and between species.

  7. Using iPods[R] and iPads[R] in Teaching Programs for Individuals with Developmental Disabilities: A Systematic Review

    Science.gov (United States)

    Kagohara, Debora M.; van der Meer, Larah; Ramdoss, Sathiyaprakash; O'Reilly, Mark F.; Lancioni, Giulio E.; Davis, Tonya N.; Rispoli, Mandy; Lang, Russell; Marschik, Peter B.; Sutherland, Dean; Green, Vanessa A.; Sigafoos, Jeff

    2013-01-01

    We conducted a systematic review of studies that involved iPods[R], iPads[R], and related devices (e.g., iPhones[R]) in teaching programs for individuals with developmental disabilities. The search yielded 15 studies covering five domains: (a) academic, (b) communication, (c) employment, (d) leisure, and (e) transitioning across school settings.…

  8. 34 CFR 403.1 - What is the State Vocational and Applied Technology Education Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What is the State Vocational and Applied Technology... TECHNOLOGY EDUCATION PROGRAM General § 403.1 What is the State Vocational and Applied Technology Education Program? (a) Under the State Vocational and Applied Technology Education Program, the Secretary makes...

  9. High-speed civil transport issues and technology program

    Science.gov (United States)

    Hewett, Marle D.

    1992-01-01

    A strawman program plan is presented, consisting of technology developments and demonstrations required to support the construction of a high-speed civil transport. The plan includes a compilation of technology issues related to the development of a transport. The issues represent technical areas in which research and development are required to allow airframe manufacturers to pursue an HSCT development. The vast majority of technical issues presented require flight demonstrated and validated solutions before a transport development will be undertaken by the industry. The author believes that NASA is the agency best suited to address flight demonstration issues in a concentrated effort. The new Integrated Test Facility at NASA Dryden Flight Research Facility is considered ideally suited to the task of supporting ground validations of proof-of-concept and prototype system demonstrations before night demonstrations. An elaborate ground hardware-in-the-loop (iron bird) simulation supported in this facility provides a viable alternative to developing an expensive fill-scale prototype transport technology demonstrator. Drygen's SR-71 assets, modified appropriately, are a suitable test-bed for supporting flight demonstrations and validations of certain transport technology solutions. A subscale, manned or unmanned flight demonstrator is suitable for flight validation of transport technology solutions, if appropriate structural similarity relationships can be established. The author contends that developing a full-scale prototype transport technology demonstrator is the best alternative to ensuring that a positive decision to develop a transport is reached by the United States aerospace industry.

  10. Investigating a Developmentally Focused Youth Sports Program for Girls in Elementary Grades

    Science.gov (United States)

    Feathers, Rebecca Zarzycki

    2012-01-01

    The purpose of this study was to identify the impact the Girls on the Run (GOTR) program had on the New Castle County, Delaware, third, fourth, and fifth grade girls who participated in the spring 2011 season. Specifically, this study examined short-term changes in the participants as they related to self-esteem, body image, physical activity…

  11. The EMERGE Summer Program: Supporting Incoming Freshmen's Success in Mathematics Developmental Coursework

    Science.gov (United States)

    Bird, Katherine; Oppland-Cordell, Sarah; Hibdon, Joseph

    2016-01-01

    This paper describes the development, results, and future directions of the mathematics component of the EMERGE Summer Program at Northeastern Illinois University. Initiated summer 2014, EMERGE offered English and mathematics sessions for incoming freshmen. The mathematics session aimed to strengthen participants' mathematical foundations,…

  12. The Effects of a Model Developmental Mathematics Program on Elementary and Middle School Preservice Teachers

    Science.gov (United States)

    Gerber, Lindsey N.

    2012-01-01

    Teacher quality is instrumental in improving student performance. Unfortunately, discrepancies between teacher preparation programs and national and state K-12 student standards have contributed to the difficult task of producing quality teachers. The contemporary mathematics education paradigm used at most colleges and universities relies on…

  13. Preliminary proposal for a beryllium technology program for fusion applications

    International Nuclear Information System (INIS)

    1985-02-01

    The program was designed to provide the answers to the critical issues of beryllium technology needed in fusion blanket designs. The four tasks are as follows: (1) Beryllium property measurements needed for fusion data base. (2) Beryllium stress relaxation and creep measurements for lifetime modelling calculations. (3) Simplified recycle technique development for irradiated beryllium. (4) Beryllium neutron multiplier measurements using manganese bath absolute calibration techniques

  14. NASA-UVa light aerospace alloy and structures technology program

    Science.gov (United States)

    Gangloff, Richard P.; Haviland, John K.; Herakovich, Carl T.; Pilkey, Walter D.; Pindera, Marek-Jerzy; Scully, John R.; Stoner, Glenn E.; Swanson, Robert E.; Thornton, Earl A.; Wawner, Franklin E., Jr.

    1991-01-01

    The general objective of the NASA-UVa Light Aerospace Alloy and Structures Technology Program was to conduct research on the performance of next generation, light weight aerospace alloys, composites, and associated thermal gradient structures. The following research areas were actively investigated: (1) mechanical and environmental degradation mechanisms in advanced light metals and composites; (2) aerospace materials science; (3) mechanics of materials and composites for aerospace structures; and (4) thermal gradient structures.

  15. Future directions of defense programs high-level waste technology programs

    International Nuclear Information System (INIS)

    Chee, T.C.; Shupe, M.W.; Turner, D.A.; Campbell, M.H.

    1987-01-01

    The Department of Energy has been managing high-level waste from the production of nuclear materials for defense activities over the last forty years. An objective for the Defense Waste and Transportation Management program is to develop technology which ensures the safe, permanent disposal of all defense radioactive wastes. Technology programs are underway to address the long-term strategy for permanent disposal of high-level waste generated at each Department of Energy site. Technology is being developed for assessing the hazards, environmental impacts, and costs of each long-term disposal alternative for selection and implementation. This paper addresses key technology development areas, and consideration of recent regulatory requirements associated with the long-term management of defense radioactive high-level waste

  16. "Fort Valley State University Cooperative Developmental Energy Program: Broadening the Participation of Underrepresented Minorities in the Geosciences"

    Science.gov (United States)

    Crumbly, I.; Hodges, J.; Kar, A.; Rashidi, L.

    2015-12-01

    According to the American Geological Institute's Status of Recent Geoscience Graduates, 2014, underrepresented minorities (URMs) make up only 7%, 5%, and 2% of graduates at the BS/BA, MA/MS, and Ph.D levels, respectively. Recruiting academically-talented URMs to major in the geosciences instead of majoring in other fields such as medicine, law, business, or engineering is a major undertaking. Numerous factors may contribute as to why few URMs choose geoscience careers. To address the underrepresentation of URMs in the geosciences 1992, the Cooperative Developmental Energy Program (CDEP) of Fort Valley State University (FVSU) and the College of Geosciences at the University of Oklahoma (OU) implemented a 3 + 2 dual degree program specifically in geology and geophysics. Since 1992, FVSU-CDEP has added the University of Texas at Austin (2004), Pennsylvania State University (2005), University of Arkansas (2010), and the University of Nevada at Las Vegas (2015) as partners to offer degrees in geology and geophysics. The dual degree programs consist of students majoring in chemistry or mathematics at FVSU for the first three years and transferring to one of the above partnering universities for years four and five to major in geology or geophysics. Upon completion of the program, students receive a BS degree in chemistry or mathematics from FVSU and a BS degree in geology or geophysics from a partnering university. CDEP has been responsible for recruiting 33 URMs who have earned BS degrees in geology or geophysics. Females constitute 50% of the graduates which is higher than the national average. Also, 56% of these graduates have earned the MS degree and 6% have earned the Ph.D. Currently, 60% of these graduates are employed with oil and gas companies; 20% work for academia; 12% work for governmental agencies; 6 % are professionals with environmental firms; and 2% of the graduate's employment is unknown.

  17. Monsanto Mound Laboratory tritium waste control technology development program

    International Nuclear Information System (INIS)

    Bixel, J.C.; Kershner, C.J.; Rhinehammer, T.B.

    1975-01-01

    Over the past four years, implementation of tritium waste control programs has resulted in a 30-fold reduction in the gaseous tritium effluents from Mound Laboratory. However, to reduce tritium waste levels to the ''as low as practicable'' guideline poses problems that are beyond ready solution with state-of-the-art tritium control technology. To meet this advanced technology need, a tritium waste control technology program was initiated. Although the initial thrust of the work under this program was oriented toward development of gaseous effluent treatment systems, its natural evolution has been toward the liquid waste problem. It is thought that, of all the possible approaches to disposal of tritiated liquid wastes, recovery offers the greatest advantages. End products of the recovery processes would be water detritiated to a level below the Radioactivity Concentration Guide (RCG) or detritiated to a level that would permit safe recycle in a closed loop operation and enriched tritium. The detritiated water effluent could be either recycled in a closed loop operation such as in a fuel reprocessing plant or safely released to the biosphere, and the recovered tritium could be recycled for use in fusion reactor studies or other applications

  18. Accelerator technology program. Progress report, July-December 1980

    International Nuclear Information System (INIS)

    Knapp, E.A.; Jameson, R.A.

    1982-01-01

    The activities of Los Alamos National Laboratory's Accelerator Technology Division are discussed. This report covers the last six months of calendar 1980 and is organized around the Division's major projects. These projects reflect a wide variety of applications and sponsors. The major technological innovations promoted by the Pion Generator for Medical Irradiation (PIGMI) program have been developed; accelerator technologies relevant to the design of a medically practical PIGMI have been identified. A new group in AT Division deals with microwave and magnet studies; we describe the status of some of their projects. We discuss the prototype gyrocon, which has been completed, and the development of the radio-frequency quadrupole linear accelerator, which continues to stimulate interest for many possible applications. One section of this report briefly describes the results of a design study for an electron beam ion source that is ideally suited as an injector for a heavy ion linac; another section reports on a turbine engine test facility that will expose operating turbine engines to simulated maneuver forces. In other sections we discuss various activities: the Fusion Materials Irradiation Test program, the free-electron laser program, the racetrack microtron project, the Proton Storage ring, and H - ion sources and injectors

  19. Status of the DOE Battery and Electrochemical Technology Program V

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, R.

    1985-06-01

    The program consists of two activities, Technology Base Research (TBR) managed by the Lawrence Berkeley Laboratory (LBL) and Exploratory Technology Development and Testing (EDT) managed by the Sandia National Laboratories (SNL). The status of the Battery Energy Storage Test (BEST) Facility is presented, including the status of the batteries to be tested. ECS program contributions to the advancement of the lead-acid battery and specific examples of technology transfer from this program are given. The advances during the period December 1982 to June 1984 in the characterization and performance of the lead-acid, iron/nickel-oxide, iron/air, aluminum/air, zinc/bromide, zinc/ferricyanide, and sodium/sulfur batteries and in fuel cells for transport are summarized. Novel techniques and the application of established techniques to the study of electrode processes, especially the electrode/electrolyte interface, are described. Research with the potential of leading to improved ceramic electrolytes and positive electrode container and current-collectors for the sodium/sulfur battery is presented. Advances in the electrocatalysis of the oxygen (air) electrode and the relationship of these advances to the iron/air and aluminum/air batteries and to the fuel cell are noted. The quest for new battery couples and battery materials is reviewed. New developments in the modeling of electrochemical cell and electrode performance with the approaches to test these models are reported.

  20. Technology Roadmap Research Program for the Steel Industry

    Energy Technology Data Exchange (ETDEWEB)

    Joseph R. Vehec

    2010-12-30

    The steel industry's Technology Roadmap Program (TRP) is a collaborative R&D effort jointly sponsored by the steel industry and the United States Department of Energy. The TRP program was designed to develop new technologies to save energy , increase competitiveness, and improve the environment. TRP ran from July, 1997 to December, 2008, with a total program budget of $38 million dollars. During that period 47 R&D projects were performed by 28 unique research organizations; co-funding was provided by DOE and 60 industry partners. The projects benefited all areas of steelmaking and much know-how was developed and transferred to industry. The American Iron and Steel Institute is the owner of all intellectual property developed under TRP and licenses it at commercial rates to all steelmakers. TRP technologies are in widespread use in the steel industry as participants received royalty-free use of intellectual property in return for taking the risk of funding this research.

  1. Graphite electrode DC arc technology program for buried waste treatment

    International Nuclear Information System (INIS)

    Wittle, J.K.; Hamilton, R.A.; Cohn, D.R.; Woskov, P.P.; Thomas, P.; Surma, J.E.; Titus, C.H.

    1994-01-01

    The goal of the program is to apply EPI's Arc Furnace to the processing of Subsurface Disposal Area (SDA) waste from Idaho National Engineering Laboratory. This is being facilitated through the Department of Energy's Buried Waste Integrated Demonstration (BWID) program. A second objective is to apply the diagnostics capability of MIT's Plasma Fusion Center to the understanding of the high temperature processes taking place in the furnace. This diagnostics technology has promise for being applicable in other thermal treatment processes. The program has two parts, a test series in an engineering-scale DC arc furnace which was conducted in an EPI furnace installed at the Plasma Fusion Center and a pilot-scale unit which is under construction at MIT. This pilot-scale furnace will be capable of operating in a continuous feed and continuous tap mode. Included in this work is the development and implementation of diagnostics to evaluate high temperature processes such as DC arc technology. This technology can be used as an effective stabilization process for Superfund wastes

  2. Bioenergy Technologies Office Multi-Year Program Plan. March 2016

    Energy Technology Data Exchange (ETDEWEB)

    Schwab, Amy [Bioenergy Technologies Office, Washington, DC (United States)

    2016-03-01

    The Bioenergy Technologies Office is one of the 10 technology development offices within the Office of Energy Efficiency and Renewable Energy at the U.S. Department of Energy. This Multi-Year Program Plan (MYPP) sets forth the goals and structure of the Bioenergy Technologies Office (the Office). It identifies the research, development, and demonstration (RD&D), and market transformation and crosscutting activities the Office will focus on over the next five years and outlines why these activities are important to meeting the energy and sustainability challenges facing the nation. This MYPP is intended for use as an operational guide to help the Office manage and coordinate its activities, as well as a resource to help communicate its mission and goals to stakeholders and the public.

  3. Role of the Small Intestine in Developmental Programming: Impact of Maternal Nutrition on the Dam and Offspring123

    Science.gov (United States)

    Meyer, Allison M; Caton, Joel S

    2016-01-01

    Small-intestinal growth and function are critical for optimal animal growth and health and play a major role in nutrient digestion and absorption, energy and nutrient expenditure, and immunological competence. During fetal and perinatal development, the small intestine is affected by the maternal environment and nutrient intake. In ruminants, altered small-intestinal mass, villi morphology, hypertrophy, hyperplasia, vascularity, and gene expression have been observed as a result of poor gestational nutrition or intrauterine growth restriction. Although many of these data come from fetal stages, data have also demonstrated that nutrition during mid- and late gestation affects lamb small-intestinal growth, vascularity, digestive enzyme activity, and gene expression at 20 and 180 d of age as well. The small intestine is known to be a highly plastic tissue, changing with nutrient intake and physiological state even in adulthood, and the maternal small intestine adapts to pregnancy and advancing gestation. In ruminants, the growth, vascularity, and gene expression of the maternal small intestine also adapt to the nutritional plane and specific nutrient intake such as high selenium during pregnancy. These changes likely alter both pre- and postnatal nutrient delivery to offspring. More research is necessary to better understand the role of the offspring and maternal small intestines in whole-animal responses to developmental programming, but programming of this plastic tissue seems to play a dynamic role in gestational nutrition impacts on the whole animal. PMID:27180380

  4. Developmental programming: effect of prenatal steroid excess on intraovarian components of insulin signaling pathway and related proteins in sheep.

    Science.gov (United States)

    Ortega, Hugo H; Rey, Florencia; Velazquez, Melisa M L; Padmanabhan, Vasantha

    2010-06-01

    Prenatal testosterone (T) excess increases ovarian follicular recruitment, follicular persistence, insulin resistance, and compensatory hyperinsulinemia. Considering the importance of insulin in ovarian physiology, in this study, using prenatal T- and dihydrotestosterone (DHT, a nonaromatizable androgen)-treated female sheep, we tested the hypothesis that prenatal androgen excess alters the intraovarian insulin signaling cascade and metabolic mediators that have an impact on insulin signaling. Changes in ovarian insulin receptor (INSRB), insulin receptor substrate 1 (IRS1), mammalian target of rapamycin (MTOR), phosphatidylinositol 3-kinase (PIK3), peroxisome proliferator-activated receptor-gamma (PPARG), and adiponectin proteins were determined at fetal (Days 90 and 140), postpubertal (10 mo), and adult (21 mo) ages by immunohistochemistry. Results indicated that these proteins were expressed in granulosa, theca, and stromal compartments, with INSRB, IRS1, PPARG, and adiponectin increasing in parallel with advanced follicular differentiation. Importantly, prenatal T excess induced age-specific changes in PPARG and adiponectin expression, with increased PPARG expression evident during fetal life and decreased antral follicular adiponectin expression during adult life. Comparison of developmental changes in prenatal T and DHT-treated females found that the effects on PPARG were programmed by androgenic actions of T, whereas the effects on adiponectin were likely by its estrogenic action. These results suggest a role for PPARG in the programming of ovarian disruptions by prenatal T excess, including a decrease in antral follicular adiponectin expression and a contributory role for adiponectin in follicular persistence and ovulatory failure.

  5. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    Weakley, Steven A.; Brown, Scott A.

    2011-09-29

    The purpose of the project described in this report is to identify and document the commercial and emerging (projected to be commercialized within the next 3 years) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies (FCT) Program in the Office of Energy Efficiency and Renewable Energy (EERE). To do this, Pacific Northwest National Laboratory (PNNL) undertook two efforts simultaneously to accomplish this project. The first effort was a patent search and analysis to identify hydrogen- and fuel-cell-related patents that are associated with FCT-funded projects (or projects conducted by DOE-EERE predecessor programs) and to ascertain the patents current status, as well as any commercial products that may have used the technology documented in the patent. The second effort was a series of interviews with current and past FCT personnel, a review of relevant program annual reports, and an examination of hydrogen- and fuel-cell-related grants made under the Small Business Innovation Research and Small Business Technology Transfer Programs, and within the FCT portfolio.

  6. Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program

    Energy Technology Data Exchange (ETDEWEB)

    Weakley, Steven A.

    2012-09-28

    The purpose of the project described in this report is to identify and document the commercial and emerging (projected to be commercialized within the next 3 years) hydrogen and fuel cell technologies and products that resulted from Department of Energy support through the Fuel Cell Technologies (FCT) Program in the Office of Energy Efficiency and Renewable Energy (EERE). Pacific Northwest National Laboratory (PNNL) undertook two efforts simultaneously to accomplish this project. The first effort was a patent search and analysis to identify patents related to hydrogen and fuel cells that are associated with FCT-funded projects (or projects conducted by DOE-EERE predecessor programs) and to ascertain the patents’ current status, as well as any commercial products that may have used the technology documented in the patent. The second effort was a series of interviews with current and past FCT personnel, a review of relevant program annual reports, and an examination of grants made under the Small Business Innovation Research and Small Business Technology Transfer Programs that are related to hydrogen and fuel cells.

  7. Magnetic Fusion Energy Technology Fellowship Program: Summary of program activities for calendar year 1985

    International Nuclear Information System (INIS)

    1985-01-01

    This report summarizes the activities of the US Department of Energy (DOE) Magnetic Fusion Energy Technology Fellowship program (MFETF) for the 1985 calendar year. The MFETF program has continued to support the mission of the Office of Fusion Energy (OFE) and its Division of Development and Technology (DDT) by ensuring the availability of appropriately trained engineering manpower needed to implement the OFE/DDT magnetic fusion energy agenda. This program provides training and research opportunities to highly qualified students at DOE-designated academic, private sector, and government magnetic fusion energy institutions. The objectives of the Magnetic Fusion Energy Technology Fellowship program are: (1) to provide support for graduate study, training, and research in magnetic fusion energy technology; (2) to ensure an adequate supply of appropriately trained manpower to implement the nation's magnetic fusion energy agenda; (3) to raise the visibility of careers in magnetic fusion energy technology and to encourage students to pursue such careers; and (4) to make national magnetic fusion energy facilities available for manpower training

  8. Nuclear technology programs semiannual progress report, April--September 1989

    International Nuclear Information System (INIS)

    Harmon, J.E.

    1991-08-01

    This document reports on the work done by the Nuclear Technology Program of the Chemical Technology Division, Argonne National Laboratory, in the period April--September 1989. These programs involve R ampersand D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions, the thermophysical properties of metal fuel and blanket materials of the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. Another effort is concerned with developing a process for separating the organic and inorganic constitutents of the red-water waste stream generated in production of 2,4,6-trinitrotoluene. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation's high-level waste repositories. 154 refs., 154 figs., 100 tabs

  9. Nuclear Technology Programs semiannual progress report, April-- September 1990

    Energy Technology Data Exchange (ETDEWEB)

    Harmon, J.E. (ed.)

    1992-06-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period April--September 1990. These programs involve R D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions in a light water reactor, the thermophysical properties of the metal fuel in the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation's high-level waste repositories.

  10. Nuclear Technology Programs semiannual progress report, April-- September 1990

    Energy Technology Data Exchange (ETDEWEB)

    Harmon, J.E. [ed.

    1992-06-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period April--September 1990. These programs involve R&D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions in a light water reactor, the thermophysical properties of the metal fuel in the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation`s high-level waste repositories.

  11. Nuclear Technology Programs semiannual progress report, October 1988--March 1989

    Energy Technology Data Exchange (ETDEWEB)

    Harmon, J.E. [ed.

    1990-12-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period October 1988--March 1989. These programs involve R&D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions, the thermophysical properties of metal fuel and blanket materials of the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. Another effort is concerned with examining the feasibility of substituting low-enriched for high-enriched uranium in the production of fission product {sup 99}Mo. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation`s high-level waste repositories. 127 refs., 76 figs., 103 tabs.

  12. Nuclear technology programs; Semiannual progress report, October 1989--March 1990

    Energy Technology Data Exchange (ETDEWEB)

    Harmon, J.E. [ed.

    1992-01-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period October 1989--March 1990. These programs involve R&D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions, the thermophysical properties of metal fuel and blanket materials of the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. Another effort is concerned water waste stream generated in production of 2,4,6-trinitrotoluene. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation`s high-level waste repositories.

  13. Nuclear Technology Programs semiannual progress report, October 1988--March 1989

    International Nuclear Information System (INIS)

    Harmon, J.E.

    1990-12-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period October 1988--March 1989. These programs involve R ampersand D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions, the thermophysical properties of metal fuel and blanket materials of the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. Another effort is concerned with examining the feasibility of substituting low-enriched for high-enriched uranium in the production of fission product 99 Mo. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation's high-level waste repositories. 127 refs., 76 figs., 103 tabs

  14. Nuclear technology programs. Semiannual progress report, April--September 1991

    International Nuclear Information System (INIS)

    1993-07-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period April through September 1991. These programs involve R ampersand D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions in a light water reactor, the thermophysical properties of the metal fuel in the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation's high-level waste repositories

  15. Long-Term Stewardship Program Science and Technology Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Joan McDonald

    2002-09-01

    Many of the United States’ hazardous and radioactively contaminated waste sites will not be sufficiently remediated to allow unrestricted land use because funding and technology limitations preclude cleanup to pristine conditions. This means that after cleanup is completed, the Department of Energy will have long-term stewardship responsibilities to monitor and safeguard more than 100 sites that still contain residual contamination. Long-term stewardship encompasses all physical and institutional controls, institutions, information, and other mechanisms required to protect human health and the environment from the hazards remaining. The Department of Energy Long-Term Stewardship National Program is in the early stages of development, so considerable planning is still required to identify all the specific roles and responsibilities, policies, and activities needed over the next few years to support the program’s mission. The Idaho National Engineering and Environmental Laboratory was tasked with leading the development of Science and Technology within the Long-Term Stewardship National Program. As part of that role, a task was undertaken to identify the existing science and technology related requirements, identify gaps and conflicts that exist, and make recommendations to the Department of Energy for future requirements related to science and technology requirements for long-term stewardship. This work is summarized in this document.

  16. Nuclear Technology Programs semiannual progress report, April-- September 1990

    International Nuclear Information System (INIS)

    Harmon, J.E.

    1992-06-01

    This document reports on the work done by the Nuclear Technology Programs of the Chemical Technology Division, Argonne National Laboratory, in the period April--September 1990. These programs involve R ampersand D in three areas: applied physical chemistry, separation science and technology, and nuclear waste management. The work in applied physical chemistry includes investigations into the processes that control the release and transport of fission products under accident-like conditions in a light water reactor, the thermophysical properties of the metal fuel in the Integral Fast Reactor, and the properties of selected materials in environments simulating those of fusion energy systems. In the area of separation science and technology, the bulk of the effort is concerned with developing and implementing processes for the removal and concentration of actinides from waste streams contaminated by transuranic elements. In the area of waste management, investigations are underway on the performance of materials in projected nuclear repository conditions to provide input to the licensing of the nation's high-level waste repositories

  17. Advanced Materials Development Program: Ceramic Technology for Advanced Heat Engines program plan, 1983--1993

    Energy Technology Data Exchange (ETDEWEB)

    1990-07-01

    The purpose of the Ceramic Technology for Advanced Heat Engines (CTAHE) Project is the development of an industrial technology base capable of providing reliable and cost-effective high temperature ceramic components for application in advanced heat engines. There is a deliberate emphasis on industrial'' in the purpose statement. The project is intended to support the US ceramic and engine industries by providing the needed ceramic materials technology. The heat engine programs have goals of component development and proof-of-concept. The CTAHE Project is aimed at developing generic basic ceramic technology and does not involve specific engine designs and components. The materials research and development efforts in the CTAHE Project are focused on the needs and general requirements of the advanced gas turbine and low heat rejection diesel engines. The CTAHE Project supports the DOE Office of Transportation Systems' heat engine programs, Advanced Turbine Technology Applications (ATTAP) and Heavy Duty Transport (HDT) by providing the basic technology required for development of reliable and cost-effective ceramic components. The heat engine programs provide the iterative component design, fabrication, and test development logic. 103 refs., 18 figs., 11 tabs.

  18. Principles from history, community psychology and developmental psychology applied to community based programs for deinstitutionalized youth

    OpenAIRE

    Levine, Murray

    2007-01-01

    ABSTRACT: This article analyses the issues of the deinstitutionalization of youth, and the development of community based services, using some historical data and some of the principles of community psychology. The basic premise is that there is no such thing as a social vacuum. All programs are implemented and function in an elaborate social context. RESUMO: Este artigo analisa as questões referentes à desinstitunalização dos jovens e ao desenvolvimento de serviços ...

  19. Ka-Band MMIC Subarray Technology Program (Ka-Mist)

    Science.gov (United States)

    Pottinger, W.

    1995-01-01

    Ka-band monolithic microwave integrated circuit (MMIC) arrays have been considered as having high potential for increasing the capability of space, aircraft, and land mobile communication systems in terms of scan performance, data rate, link margin, and flexibility while offering a significant reduction in size, weight, and power consumption. Insertion of MMIC technology into antenna systems, particularly at millimeter wave frequencies using low power and low noise amplifiers in closed proximity to the radiating elements, offers a significant improvement in the array transmit efficiency, receive system noise figure, and overall array reliability. Application of active array technology also leads to the use of advanced beamforming techniques that can improve beam agility, diversity, and adaptivity to complex signal environments. The objective of this program was to demonstrate the technical feasibility of the 'tile' array packaging architecture at EHF via the insertion of 1990 MMIC technology into a functional tile array or subarray module. The means test of this objective was to demonstrate and deliver to NASA a minimum of two 4 x 4 (16 radiating element) subarray modules operating in a transmit mode at 29.6 GHz. Available (1990) MMIC technology was chosen to focus the program effort on the novel interconnect schemes and packaging requirements rather than focusing on MMIC development. Major technical achievements of this program include the successful integration of two 4 x 4 subarray modules into a single antenna array. This 32 element array demonstrates a transmit EIRP of over 300 watts yielding an effective directive power gain in excess of 55 dB at 29.63 GHz. The array has been actively used as the transmit link in airborne/terrestrial mobile communication experiments accomplished via the ACTS satellite launched in August 1993.

  20. The Department of Energy's safeguards and security technology development program

    International Nuclear Information System (INIS)

    Smith, G.D.; Pocratsky, C.A.

    1995-01-01

    The US DOE has had a program that develops technologies to protect sensitive nuclear weapons facilities for more than thirty years. The mission of the program is overwhelmingly diverse, as it must be to protect an array of assets such as nuclear weapons, special nuclear material in various forms, components of nuclear weapons, and classified nuclear weapons design information. Considering that the nuclear weapons complex consists of dozens of facilities that are scattered all over the US, the technology development mission is very challenging. Complicating matters further is the ever uncertain future of the DOE. Some examples of dramatic Departmental mission changes that directly impact their security technology development program are given. A few development efforts are highlighted as examples of efforts currently being sponsored. They are: automated sensor testing devices to help reduce the requirement for personnel to enter vaults containing highly radioactive nuclear materials; a vehicle inspection portal to screen vehicles for hidden passengers, nuclear material, explosives, and other contraband; non-lead and short-range ammunition as an environmentally safe alternative to lead ammunition; a complex-wide visitor access control system to allow all DOE employees to travel to all sites with a commonly recognized credential; automated nuclear material monitoring technologies to provide assurance that material in storage has not been tampered with; laser radar as a potential solution to early warning deficiencies throughout the Department; performance testing standards for many security products to include an automated and consistent standard for assessing the quality of video; low temperature pyrotechnic smoke as a possible adversary delay mechanism; modular vaults to provide temporary protection for nuclear material during D and D activities, and a protection approach for restricted passage areas such as the volume above a tiled ceiling or within a crawl space

  1. Code Development and Analysis Program: developmental checkout of the BEACON/MOD2A code

    International Nuclear Information System (INIS)

    Ramsthaler, J.A.; Lime, J.F.; Sahota, M.S.

    1978-12-01

    A best-estimate transient containment code, BEACON, is being developed by EG and G Idaho, Inc. for the Nuclear Regulatory Commission's reactor safety research program. This is an advanced, two-dimensional fluid flow code designed to predict temperatures and pressures in a dry PWR containment during a hypothetical loss-of-coolant accident. The most recent version of the code, MOD2A, is presently in the final stages of production prior to being released to the National Energy Software Center. As part of the final code checkout, seven sample problems were selected to be run with BEACON/MOD2A

  2. A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming.

    Directory of Open Access Journals (Sweden)

    Alejandro Colaneri

    Full Text Available Cell specific states of the chromatin are programmed during mammalian development. Dynamic DNA methylation across the developing embryo guides a program of repression, switching off genes in most cell types. Thus, the majority of the tissue specific differentially methylated sites (TS-DMS must be un-methylated CpGs.Comparison of expanded Methyl Sensitive Cut Counting data (eMSCC among four tissues (liver, testes, brain and kidney from three C57BL/6J mice, identified 138,052 differentially methylated sites of which 23,270 contain CpGs un-methylated in only one tissue (TS-DMS. Most of these CpGs were located in intergenic regions, outside of promoters, CpG islands or their shores, and up to 20% of them overlapped reported active enhancers. Indeed, tissue-specific enhancers were up to 30 fold enriched in TS-DMS. Testis showed the highest number of TS-DMS, but paradoxically their associated genes do not appear to be specific to the germ cell functions, but rather are involved in organism development. In the other tissues the differentially methylated genes are associated with tissue-specific physiological or anatomical functions. The identified sets of TS-DMS quantify epigenetic distances between tissues, generated during development. We applied this concept to measure the extent of reprogramming in the liver of mice exposed to in utero or early postnatal nutritional stress. Different protocols of food restriction reprogrammed the liver methylome in different but reproducible ways.Thus, each identified set of differentially methylated sites constituted an epigenetic signature that traced the developmental programing or the early nutritional reprogramming of each exposed mouse. We propose that our approach has the potential to outline a number of disease-associated epigenetic states. The composition of differentially methylated CpGs may vary with each situation, behaving as a composite variable, which can be used as a pre-symptomatic marker for

  3. Validation of Evidence-Based Fall Prevention Programs for Adults with Intellectual and/or Developmental Disorders: A Modified Otago Exercise Program.

    Science.gov (United States)

    Renfro, Mindy; Bainbridge, Donna B; Smith, Matthew Lee

    2016-01-01

    Evidence-based fall prevention (EBFP) programs significantly decrease fall risk, falls, and fall-related injuries in community-dwelling older adults. To date, EBFP programs are only validated for use among people with normal cognition and, therefore, are not evidence-based for adults with intellectual and/or developmental disorders (IDD) such as Alzheimer's disease and related dementias, cerebral vascular accident, or traumatic brain injury. Adults with IDD experience not only a higher rate of falls than their community-dwelling, cognitively intact peers but also higher rates and earlier onset of chronic diseases, also known to increase fall risk. Adults with IDD experience many barriers to health care and health promotion programs. As the lifespan for people with IDD continues to increase, issues of aging (including falls with associated injury) are on the rise and require effective and efficient prevention. A modified group-based version of the Otago Exercise Program (OEP) was developed and implemented at a worksite employing adults with IDD in Montana. Participants were tested pre- and post-intervention using the Center for Disease Control and Prevention's (CDC) Stopping Elderly Accidents Deaths and Injuries (STEADI) tool kit. Participants participated in progressive once weekly, 1-h group exercise classes and home programs over a 7-week period. Discharge planning with consumers and caregivers included home exercise, walking, and an optional home assessment. Despite the limited number of participants ( n  = 15) and short length of participation, improvements were observed in the 30-s Chair Stand Test, 4-Stage Balance Test, and 2-Minute Walk Test. Additionally, three individuals experienced an improvement in ambulation independence. Participants reported no falls during the study period. Promising results of this preliminary project underline the need for further study of this modified OEP among adults with IDD. Future multicenter study should include more

  4. Evaluation of spacecraft technology programs (effects on communication satellite business ventures), volume 2

    Science.gov (United States)

    Greenburg, J. S.; Kaplan, M.; Fishman, J.; Hopkins, C.

    1985-01-01

    The computational procedures used in the evaluation of spacecraft technology programs that impact upon commercial communication satellite operations are discussed. Computer programs and data bases are described.

  5. Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?

    Science.gov (United States)

    Abbott, D H; Barnett, D K; Bruns, C M; Dumesic, D A

    2005-01-01

    The aetiology of polycystic ovary syndrome (PCOS) remains unknown. This familial syndrome is prevalent among reproductive-aged women and its inheritance indicates a dominant regulatory gene with incomplete penetrance. However, promising candidate genes have proven unreliable as markers for the PCOS phenotype. This lack of genetic linkage may represent both extreme heterogeneity of PCOS and difficulty in establishing a universally accepted PCOS diagnosis. Nevertheless, hyperandrogenism is one of the most consistently expressed PCOS traits. Animal models that mimic fetal androgen excess may thus provide unique insight into the origins of the PCOS syndrome. Many female mammals exposed to androgen excess in utero or during early post-natal life typically show masculinized and defeminized behaviour, ovulatory dysfunction and virilized genitalia, although behavioural and ovulatory dysfunction can coexist without virilized genitalia based upon the timing of androgen excess. One animal model shows particular relevance to PCOS: the prenatally androgenized female rhesus monkey. Females exposed to androgen excess early in gestation exhibit hyperandrogenism, oligomenorrhoea and enlarged, polyfollicular ovaries, in addition to LH hypersecretion, impaired embryo development, insulin resistance accompanying abdominal obesity, impaired insulin response to glucose and hyperlipidaemia. Female monkeys exposed to androgen excess late in gestation mimic these programmed changes, except for LH and insulin secretion defects. In utero androgen excess may thus variably perturb multiple organ system programming and thereby provide a single, fetal origin for a heterogeneous adult syndrome.

  6. A model technology transfer program for independent operators: Kansas Technology Transfer Model (KTTM)

    Energy Technology Data Exchange (ETDEWEB)

    Schoeling, L.G.

    1993-09-01

    This report describes the development and testing of the Kansas Technology Transfer Model (KTTM) which is to be utilized as a regional model for the development of other technology transfer programs for independent operators throughout oil-producing regions in the US. It describes the linkage of the regional model with a proposed national technology transfer plan, an evaluation technique for improving and assessing the model, and the methodology which makes it adaptable on a regional basis. The report also describes management concepts helpful in managing a technology transfer program. The original Tertiary Oil Recovery Project (TORP) activities, upon which the KTTM is based, were developed and tested for Kansas and have proved to be effective in assisting independent operators in utilizing technology. Through joint activities of TORP and the Kansas Geological Survey (KGS), the KTTM was developed and documented for application in other oil-producing regions. During the course of developing this model, twelve documents describing the implementation of the KTTM were developed as deliverables to DOE. These include: (1) a problem identification (PI) manual describing the format and results of six PI workshops conducted in different areas of Kansas, (2) three technology workshop participant manuals on advanced waterflooding, reservoir description, and personal computer applications, (3) three technology workshop instructor manuals which provides instructor material for all three workshops, (4) three technologies were documented as demonstration projects which included reservoir management, permeability modification, and utilization of a liquid-level acoustic measuring device, (5) a bibliography of all literature utilized in the documents, and (6) a document which describes the KTTM.

  7. Biomass Program 2007 Program Peer Review - Biodiesel and Other Technologies Summary

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-28

    This document discloses the comments provided by a review panel at the U.S. Department of Energy Office of the Biomass Program Peer Review held on November 15-16, 2007 in Baltimore, MD and the Biodiesel and Other Technologies, held on August 14th and 15th in Golden, Colorado.

  8. IMPACTS. Industrial Technologies Program: Summary of Program Results for CY 2008

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2010-08-02

    The Impacts report summarizes benefits resulting from ITP-sponsored technologies, including energy savings, waste reduction, increased productivity, and lowered emissions. It also provides an overview of the activities of the Industrial Assessment Centers, BestPractices Program, and Combined Heat and Power efforts.

  9. Overview of the Defense Programs Research and Technology Development Program for fiscal year 1993. Appendix II research laboratories and facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-30

    This document contains summaries of the research facilities that support the Defense Programs Research and Technology Development Program for FY 1993. The nine program elements are aggregated into three program clusters as follows: (1) Advanced materials sciences and technologies; chemistry and materials, explosives, special nuclear materials (SNM), and tritium. (2) Design sciences and advanced computation; physics, conceptual design and assessment, and computation and modeling. (3) Advanced manufacturing technologies and capabilities; system engineering science and technology, and electronics, photonics, sensors, and mechanical components. Section I gives a brief summary of 23 major defense program (DP) research and technology facilities and shows how these major facilities are organized by program elements. Section II gives a more detailed breakdown of the over 200 research and technology facilities being used at the Laboratories to support the Defense Programs mission.

  10. Fusion reactor design and technology program in China

    International Nuclear Information System (INIS)

    Huang, J.H.

    1994-01-01

    A fusion-fission hybrid reactor program was launched in 1987. The purpose of development of the hybrid reactor is twofold: to solve the problem of nuclear fuel supply for an expected large-scale development of fission reactor plants, and to maintain the momentum of fusion research. The program is described and the activities and progress of the program are presented. Two conceptual designs of an engineering test reactor with tokamak configuration were developed at the Southwestern Institute of Physics and the Institute of Plasma Physics. The results are a tokamak engineering test breeder (TETB) series design and a fusion-fission hybrid reactor design (SSEHR), characterized by a liquid-Li self-cooled blanket and an He-cooled solid tritium breeder blanket respectively. In parallel with the design studies, relevant technological experiments on a small or medium scale have been supported by this program. These include LHCD, ICRH and pellet injection in the area of plasma engineering; neutronics integral experiments with U, Pu, Fe and Be; various irradiation tests of austenitic and ferritic steels, magnetohydrodynamic (MHD) pressure drop experiments using a liquid metal loop; research into permeation barriers for tritium and hydrogen isotopes; solid tritium breeder tests using an in-situ loop in a fission reactor. All these experiments have proceeded successfully. The second step of this program is now starting. It seems reasonable that most of the research carried out in the first step will continue. ((orig.))

  11. Science and technology disclosure in the state of Queretaro: Science and Technology for Children program

    Science.gov (United States)

    Contreras Flores, Rubén; Villeda Muñoz, Gabriel

    2007-03-01

    Science and technology disclosure is an integral part of our scientific work as researches; it is an induction process for children, young people and teachers of primary and secondary schools in the state of Queretaro. Education must be offered in a clear and objective way, it allows to the students apply the acquired knowledge to understand the world and improve his quality of life. Nowadays, the Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada of the Instituto Politecnico Nacional Unidad Queretaro (CICATA-IPN Queretaro) together with the Consejo de Ciencia y Tecnologia del Estado de Queretaro (CONCYTEQ) have implemented the "Science and Technology for Children" program (Ciencia y Tecnologia para Ninos - CTN), it allows to the educative sector obtain information through the CONCYTEQ web page. The fist stage of the program was the development of two subjects: the brochure titled "Petroleum, Nonrenewable Natural Resource that Moves the World" and the manual "Experiments of Physics". At the moment we are working with the second stage of the program, it is about the energy generation using renewable sources such as: geothermal, aeolian, solar and biomass. The CTN program allows to students and teachers to create conscience about the importance of the development of the science of technology in our country.

  12. IAEA education and training programs in radiation technology

    International Nuclear Information System (INIS)

    Ma Zueteh

    1995-01-01

    In order to assist the promotion of the industrial application of isotopes and radiation in Southeast Asia and Pacific region, the regional IAEA/UNDP/RCA project was formed in 1982. Phase 1 was 1982-1986, Phase 2 was 1987-1991, and now it entered Phase 3, 1993-1997. 15 countries joined the project, and now the donor countries expanded to five or more including Japan, Australia, China, ROK and India. Radiation technology is one of the subprojects of the regional project, aiming at transferring this technology from developed countries to developing countries and promoting to industrialize this technology. For the purpose, technical personnel and their skill are essential, and IAEA supports and supplements the educational and training program in developing countries. Executive management seminar (EMS), national workshop (NW), regional training course (RTC) and national training courses (NTCs) are the main components of this education program. The contents of these components are explained, and the activities which were carried out so far under them are reported. (K.I.)

  13. Materials Development Program: Ceramic Technology Project bibliography, 1984--1992

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    The Ceramic Technology [for Advanced Heat Engines] Project was begun in 1983 to meet the ceramic materials needs of the companion DOE automotive engine program, the Advanced Gas Turbine (AGT) project, and the Heavy Duty Transport (low-heat-rejection, heavy-duty diesel) project. Goal is to develop an industry technology base for reliable and cost effective ceramics for applications in advanced automotive gas turbine and diesel engines. Research areas were identified following extensive input from industry and academia. Majority of research is done by industry (60%); work is also done at colleges and universities, in-house, and at other national laboratories and government agencies. In the beginning, reliability of ceramic components was the key issue. The reliability issues have largely been met and, at the present time, cost is the driving issue, especially in light of the highly cost-sensitive automotive market. Emphasis of the program has now been shifted toward developing cost-effective ceramic components for high-performance engines in the near-term. This bibliography is a compilation of publications done in conjunction with the Ceramic Technology Project since its beginning. Citations were obtained from reports done by participants in the project. We have tried to limit citations to those published and easily located. The end date of 1992 was selected.

  14. Developmental assessment of the Fort St. Vrain version of the Composite HTGR Analysis Program (CHAP-2)

    International Nuclear Information System (INIS)

    Stroh, K.R.

    1980-01-01

    The Composite HTGR Analysis Program (CHAP) consists of a model-independent systems analysis mainframe named LASAN and model-dependent linked code modules, each representing a component, subsystem, or phenomenon of an HTGR plant. The Fort St. Vrain (FSV) version (CHAP-2) includes 21 coded modules that model the neutron kinetics and thermal response of the core; the thermal-hydraulics of the reactor primary coolant system, secondary steam supply system, and balance-of-plant; the actions of the control system and plant protection system; the response of the reactor building; and the relative hazard resulting from fuel particle failure. FSV steady-state and transient plant data are being used to partially verify the component modeling and dynamic smulation techniques used to predict plant response to postulated accident sequences

  15. Developmental programming of vascular dysfunction by prenatal and postnatal zinc deficiency in male and female rats.

    Science.gov (United States)

    Mendes Garrido Abregú, Facundo; Gobetto, María Natalia; Juriol, Lorena Vanesa; Caniffi, Carolina; Elesgaray, Rosana; Tomat, Analía Lorena; Arranz, Cristina

    2018-06-01

    Micronutrient malnutrition during intrauterine and postnatal growth may program cardiovascular diseases in adulthood. We examined whether moderate zinc restriction in male and female rats throughout fetal life, lactation and/or postweaning growth induces alterations that can predispose to the onset of vascular dysfunction in adulthood. Female Wistar rats were fed low- or control zinc diets from pregnancy to offspring weaning. After weaning, offspring were fed either a low- or a control zinc diet until 81 days. We evaluated systolic blood pressure (SBP), thoracic aorta morphology, nitric oxide (NO) system and vascular reactivity in 6- and/or 81-day-old offspring. At day 6, zinc-deficient male and female offspring showed a decrease in aortic NO synthase (NOS) activity accompanied by an increase in oxidative stress. Zinc-deficient 81-day-old male rats exhibited an increase in collagen deposition in tunica media, as well as lower activity of endothelial NOS (eNOS) that could not be reversed with an adequate zinc diet during postweaning life. Zinc deficiency programmed a reduction in eNOS protein expression and higher SBP only in males. Adult zinc-deficient rats of both sexes showed reduced vasodilator response dependent on eNOS activity and impaired aortic vasoconstrictor response to angiotensin-II associated with alterations in intracellular calcium mobilization. Female rats were less sensitive to the effects of zinc deficiency and exhibited higher eNOS activity and/or expression than males, without alterations in SBP or aortic histology. This work strengthens the importance of a balanced intake of micronutrients during perinatal growth to ensure adequate vascular function in adult life. Copyright © 2018 Elsevier Inc. All rights reserved.

  16. Fostering sustainable energy entrepreneurship among students : the Business Oriented Technological System Analysis (BOTSA) program at Eindhoven University of Technology

    NARCIS (Netherlands)

    Wijnker, M.A.S.G.; Kasteren, van Han; Romijn, H.A.

    2015-01-01

    The Business Oriented Technological System Analysis (BOTSA) program is a new teaching and learning concept developed by Eindhoven University of Technology (the Netherlands) with participation from innovative companies in renewable energy. It is designed to stimulate sustainable entrepreneurship

  17. 75 FR 69049 - Expansion and Extension of the Green Technology Pilot Program

    Science.gov (United States)

    2010-11-10

    ... under the Green Technology Pilot Program is available on the USPTO's Internet Web site at http://www... Extension of the Green Technology Pilot Program AGENCY: United States Patent and Trademark Office, Commerce...) implemented the Green [[Page 69050

  18. Developmental Programming: Prenatal Testosterone Excess and Insulin Signaling Disruptions in Female Sheep.

    Science.gov (United States)

    Lu, Chunxia; Cardoso, Rodolfo C; Puttabyatappa, Muraly; Padmanabhan, Vasantha

    2016-05-01

    Women with polycystic ovary syndrome often manifest insulin resistance. Using a sheep model of polycystic ovary syndrome-like phenotype, we explored the contribution of androgen and insulin in programming and maintaining disruptions in insulin signaling in metabolic tissues. Phosphorylation of AKT, ERK, GSK3beta, mTOR, and p70S6K was examined in the liver, muscle, and adipose tissue of control and prenatal testosterone (T)-, prenatal T plus androgen antagonist (flutamide)-, and prenatal T plus insulin sensitizer (rosiglitazone)-treated fetuses as well as 2-yr-old females. Insulin-stimulated phospho (p)-AKT was evaluated in control and prenatal T-, prenatal T plus postnatal flutamide-, and prenatal T plus postnatal rosiglitazone-treated females at 3 yr of age. GLUT4 expression was evaluated in the muscle at all time points. Prenatal T treatment increased mTOR, p-p70S6K, and p-GSK3beta levels in the fetal liver with both androgen antagonist and insulin sensitizer preventing the mTOR increase. Both interventions had partial effect in preventing the increase in p-GSK3beta. In the fetal muscle, prenatal T excess decreased p-GSK3beta and GLUT4. The decrease in muscle p-GSK3beta was partially prevented by insulin sensitizer cotreatment. Both interventions partially prevented the decrease in GLUT4. Prenatal T treatment had no effect on basal expression of any of the markers in 2-yr-old females. At 3 yr of age, prenatal T treatment prevented the insulin-stimulated increase in p-AKT in liver and muscle, but not in adipose tissue, and neither postnatal intervention restored p-AKT response to insulin stimulation. Our findings provide evidence that prenatal T excess changes insulin sensitivity in a tissue- and development-specific manner and that both androgens and insulin may be involved in the programming of these metabolic disruptions. © 2016 by the Society for the Study of Reproduction, Inc.

  19. Developmental Programming of Cardiovascular Disease Following Intrauterine Growth Restriction: Findings Utilising A Rat Model of Maternal Protein Restriction

    Science.gov (United States)

    Zohdi, Vladislava; Lim, Kyungjoon; Pearson, James T.; Black, M. Jane

    2014-01-01

    Over recent years, studies have demonstrated links between risk of cardiovascular disease in adulthood and adverse events that occurred very early in life during fetal development. The concept that there are embryonic and fetal adaptive responses to a sub-optimal intrauterine environment often brought about by poor maternal diet that result in permanent adverse consequences to life-long health is consistent with the definition of “programming”. The purpose of this review is to provide an overview of the current knowledge of the effects of intrauterine growth restriction (IUGR) on long-term cardiac structure and function, with particular emphasis on the effects of maternal protein restriction. Much of our recent knowledge has been derived from animal models. We review the current literature of one of the most commonly used models of IUGR (maternal protein restriction in rats), in relation to birth weight and postnatal growth, blood pressure and cardiac structure and function. In doing so, we highlight the complexity of developmental programming, with regards to timing, degree of severity of the insult, genotype and the subsequent postnatal phenotype. PMID:25551250

  20. Space Missions for Automation and Robotics Technologies (SMART) Program

    Science.gov (United States)

    Cliffone, D. L.; Lum, H., Jr.

    1985-01-01

    NASA is currently considering the establishment of a Space Mission for Automation and Robotics Technologies (SMART) Program to define, develop, integrate, test, and operate a spaceborne national research facility for the validation of advanced automation and robotics technologies. Initially, the concept is envisioned to be implemented through a series of shuttle based flight experiments which will utilize telepresence technologies and real time operation concepts. However, eventually the facility will be capable of a more autonomous role and will be supported by either the shuttle or the space station. To ensure incorporation of leading edge technology in the facility, performance capability will periodically and systematically be upgraded by the solicitation of recommendations from a user advisory group. The facility will be managed by NASA, but will be available to all potential investigators. Experiments for each flight will be selected by a peer review group. Detailed definition and design is proposed to take place during FY 86, with the first SMART flight projected for FY 89.

  1. Engineering, Analysis and Technology FY 1995 Site Support Program Plan

    International Nuclear Information System (INIS)

    Suyama, R.M.

    1994-09-01

    The vision of the Engineering, Analysis and Technology organization is to be recognized as the cost-effective supplier of specialized, integrated, multi-disciplined engineering teams to support Hanford missions. The mission of the Engineering, Analysis and Technology organization is to provide centralized engineering services. These services are focused on supplying technical design, analytical engineering and related support services that support Hanford's environmental restoration mission. These services include engineering analysis, design and development of systems and engineered equipment, supplying multi-disciplined engineering teams to all Hanford programs and project organizations, engineering document release, and site-wide leadership in the development and implementation of engineering standards, engineering practices, and configuration management processes

  2. Portable Computer Technology (PCT) Research and Development Program Phase 2

    Science.gov (United States)

    Castillo, Michael; McGuire, Kenyon; Sorgi, Alan

    1995-01-01

    The subject of this project report, focused on: (1) Design and development of two Advanced Portable Workstation 2 (APW 2) units. These units incorporate advanced technology features such as a low power Pentium processor, a high resolution color display, National Television Standards Committee (NTSC) video handling capabilities, a Personal Computer Memory Card International Association (PCMCIA) interface, and Small Computer System Interface (SCSI) and ethernet interfaces. (2) Use these units to integrate and demonstrate advanced wireless network and portable video capabilities. (3) Qualification of the APW 2 systems for use in specific experiments aboard the Mir Space Station. A major objective of the PCT Phase 2 program was to help guide future choices in computing platforms and techniques for meeting National Aeronautics and Space Administration (NASA) mission objectives. The focus being on the development of optimal configurations of computing hardware, software applications, and network technologies for use on NASA missions.

  3. Support to X-33/Reusable Launch Vehicle Technology Program

    Science.gov (United States)

    2000-01-01

    The Primary activities of Lee & Associates for the referenced Purchase Order has been in direct support of the X-33/Reusable Launch Vehicle Technology Program. An independent review to evaluate the X-33 liquid hydrogen fuel tank failure, which recently occurred after-test of the starboard tank has been provided. The purpose of the Investigation team was to assess the tank design modifications, provide an assessment of the testing approach used by MSFC (Marshall Space Flight Center) in determining the flight worthiness of the tank, assessing the structural integrity, and determining the cause of the failure of the tank. The approach taken to satisfy the objectives has been for Lee & Associates to provide the expertise of Mr. Frank Key and Mr. Wayne Burton who have relevant experience from past programs and a strong background of experience in the fields critical to the success of the program. Mr. Key and Mr. Burton participated in the NASA established Failure Investigation Review Team to review the development and process data and to identify any design, testing or manufacturing weaknesses and potential problem areas. This approach worked well in satisfying the objectives and providing the Review Team with valuable information including the development of a Fault Tree. The detailed inputs were made orally in real time in the Review Team daily meetings. The results of the investigation were presented to the MSFC Center Director by the team on February 15, 2000. Attached are four charts taken from that presentation which includes 1) An executive summary, 2) The most probable cause, 3) Technology assessment, and 4) Technology Recommendations for Cryogenic tanks.

  4. EM-54 Technology Development In Situ Remediation Integrated Program

    International Nuclear Information System (INIS)

    1993-08-01

    The Department of Energy (DOE) established the Office of Technology Development (EM-50) as an element of Environmental Restoration and Waste Management (EM) in November 1989. EM manages remediation of all DOE sites as well as wastes from current operations. The goal of the EM program is to minimize risks to human health, safety and the environment, and to bring all DOE sites into compliance with Federal, state, and local regulations by 2019. EM-50 is charged with developing new technologies that are safer, more effective and less expensive than current methods. The In Situ Remediation Integrated Program (the subject of this report) is part of EM-541, the Environmental Restoration Research and Development Division of EM-54. The In Situ Remediation Integrated Program (ISR IP) was instituted out of recognition that in situ remediation could fulfill three important criteria: Significant cost reduction of cleanup by eliminating or minimizing excavation, transportation, and disposal of wastes; reduced health impacts on workers and the public by minimizing exposure to wastes during excavation and processing; and remediation of inaccessible sites, including: deep subsurfaces; in, under, and around buildings. Buried waste, contaminated soils and groundwater, and containerized wastes are all candidates for in situ remediation. Contaminants include radioactive wastes, volatile and non-volatile organics, heavy metals, nitrates, and explosive materials. The ISR IP tends to facilitate development of in situ remediation technologies for hazardous, radioactive, and mixed wastes in soils, groundwater, and storage tanks. Near-term focus is on containment of the wastes, with treatment receiving greater effort in future years

  5. Developmental assessment of the Fort St. Vrain version of the composite HTGR analysis program (CHAP-2)

    International Nuclear Information System (INIS)

    Stroh, K.R.

    1981-01-01

    The Composite HTGR Analysis Program (CHAP) consists of a model-independent systems analysis mainframe named LASAN and model-dependent linked code modules, each representing a component, subsystem, or phenomenon of an HTGR plant. The Fort St. Vrain version (CHAP-2) includes 21 coded modules that model the neutron kinetics and thermal response of the core; the thermal-hydraulics of the reactor primary coolant system, secondary steam supply system, and balance-of-plant; the actions of the control system and plant protection system; the response of the reactor building; and the relative hazard resulting from fuel particle failure. FSV steady-state and transient plant data are being used to partially verify the component modeling and dynamic simulation techniques used to predict plant response to postulated accident sequences. Results of these preliminary validation efforts are presented showing good agreement between code output and plant data for the portions of the code that have been tested. Plans for further development and assessment as well as application of the validated code are discussed. (author)

  6. Developmental Programming of Obesity and Liver Metabolism by Maternal Perinatal Nutrition Involves the Melanocortin System

    Directory of Open Access Journals (Sweden)

    Paul Cordero

    2017-09-01

    Full Text Available Maternal obesity predisposes offspring to metabolic dysfunction and Non-Alcoholic Fatty Liver Disease (NAFLD. Melanocortin-4 receptor (Mc4r-deficient mouse models exhibit obesity during adulthood. Here, we aim to determine the influence of the Mc4r gene on the liver of mice subjected to perinatal diet-induced obesity. Female mice heterozygous for Mc4r fed an obesogenic or a control diet for 5 weeks were mated with heterozygous males, with the same diet continued throughout pregnancy and lactation, generating four offspring groups: control wild type (C_wt, control knockout (C_KO, obese wild type (Ob_wt, and obese knockout (Ob_KO. At 21 days, offspring were genotyped, weaned onto a control diet, and sacrificed at 6 months old. Offspring phenotypic characteristics, plasma biochemical profile, liver histology, and hepatic gene expression were analyzed. Mc4r_ko offspring showed higher body, liver and adipose tissue weights respect to the wild type animals. Histological examination showed mild hepatic steatosis in offspring group C_KO. The expression of hepatic genes involved in regulating inflammation, fibrosis, and immune cell infiltration were upregulated by the absence of the Mc4r gene. These results demonstrate that maternal obesogenic feeding during the perinatal period programs offspring obesity development with involvement of the Mc4r system.

  7. Developmental programming of metabolic diseases – a review of studies on experimental animal models

    Directory of Open Access Journals (Sweden)

    Iwona Piotrowska

    2014-06-01

    Full Text Available Growth and development in utero is a complex and dynamic process that requires interaction between the mother organism and the fetus. The delivery of macro – and micronutrients, oxygen and endocrine signals has crucial importance for providing a high level of proliferation, growth and differentiation of cells, and a disruption in food intake not only has an influence on the growth of the fetus, but also has negative consequences for the offspring’s health in the future. Diseases that traditionally are linked to inappropriate life style of adults, such as type 2 diabetes, obesity, and arterial hypertension, can be “programmed” in the early stage of life and the disturbed growth of the fetus leads to the symptoms of the metabolic syndrome. The structural changes of some organs, such as the brain, pancreas and kidney, modifications of the signaling and metabolic pathways in skeletal muscles and in fatty tissue, epigenetic mechanisms and mitochondrial dysfunction are the basis of the metabolic disruptions. The programming of the metabolic disturbances is connected with the disruption in the intrauterine environment experienced in the early and late gestation period. It causes the changes in deposition of triglycerides, activation of the hormonal “stress axis” and disturbances in the offspring’s glucose tolerance. The present review summarizes experimental results that led to the identification of the above-mentioned links and it underlines the role of animal models in the studies of this important concept.

  8. Accelerator Technology Program. Status report, October 1983-March 1984

    International Nuclear Information System (INIS)

    Jameson, R.A.

    1985-01-01

    This report covers major projects in the Accelerator Technology (AT) Division of the Los Alamos National Laboratory. The first sections highlight activities related to beam dynamics, inertial fusion, structure development, the racetrack microtron, and the CERN high-energy physics experiment NA-12. Discussed next is the Fusion Materials Irradiation Test Facility, followed by a summary of progress on the Proton Storage Ring and activities of the Theory and Simulation Group. The report concludes with a discussion of the H- accelerator program and a listing of papers published by AT-Division personnel during this reporting period

  9. Compressed air energy storage technology program. Annual report for 1980

    Energy Technology Data Exchange (ETDEWEB)

    Kannberg, L.D.

    1981-06-01

    All of the major research funded under the Compressed Air Energy Storage Technology Program during the period March 1980 to March 1981 is described. This annual report is divided into two segments: Reservoir Stability Studies and Second-Generation Concepts Studies. The first represents research performed to establish stability criteria for CAES reservoirs while the second reports progress on research performed on second-generation CAES concepts. The report consists of project reports authored by research engineers and scientists from PNL and numerous subcontractors including universities, architect-engineering, and other private firms.

  10. Technology needs for environmental restoration remedial action. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Watson, J.S.

    1992-11-01

    This report summarizes the current view of the most important technology needs for the US Department of Energy (DOE) facilities operated by Martin Marietta Energy Systems, Inc. These facilities are the Oak Ridge National Laboratory, the Oak Ridge K-25 Site, the Oak Ridge Y-12 Plant, the Paducah Gaseous Diffusion Plant, and the Portsmouth Gaseous Diffusion Plant. The sources of information used in this assessment were a survey of selected representatives of the Environmental Restoration (ER) programs at each facility, results from a questionnaire distributed by Geotech CWM, Inc., for DOE, and associated discussions with individuals from each facility. This is not a final assessment, but a brief look at an ongoing assessment; the needs will change as the plans for restoration change and, it is hoped, as some technical problems are solved through successful development programs.

  11. Massachusetts Institute of Technology, Plasma Fusion Center, technical research programs

    International Nuclear Information System (INIS)

    1982-02-01

    Research programs have produced significant results on four fronts: (1) the basic physics of high-temperature fusion plasmas (plasma theory, RF heating, development of advanced diagnostics and small-scale experiments on the Versator tokamak and Constance mirror devices); (2) major confinement results on the Alcator A and C tokamaks, including pioneering investigations of the equilibrium, stability, transport and radiation properties of fusion plasmas at high densities, temperatures and magnetic fields; (3) development of a new and innovative design for axisymmetric tandem mirrors with inboard thermal barriers, with initial operation of the TARA tandem mirror experimental facility scheduled for 1983; and (4) a broadly based program of fusion technology and engineering development that addresses problems in several critical subsystem areas

  12. Results of the pollution reduction technology program for turboprop engines

    Science.gov (United States)

    Mularz, E. J.

    1976-01-01

    A program was performed to evolve and demonstrate advanced combustor technology aimed at achieving the 1979 EPA standards for turboprop engines (Class P2). The engine selected for this program was the 501-D22A turboprop manufactured by Detroit Diesel Allison Division of General Motors Corporation. Three combustor concepts were designed and tested in a combustor rig at the exact combustor operating conditions of the 501-D22A engine over the EPA landing-takeoff cycle. Each combustor concept exhibited pollutant emissions well below the EPA standards, achieving substantial reductions in unburned hydrocarbons, carbon monoxide, and smoke emissions compared with emissions from the production combustor of this engine. Oxides of nitrogen emissions remained well below the EPA standards, also.

  13. DOE/PNC joint program on transportation technology

    International Nuclear Information System (INIS)

    Kubo, M.; Kajitani, M.; Seya, M.; Yoshimura, H.R.; Moya, J.L.; May, R.A.; Huerta, M.; Stenberg, D.R.

    1986-01-01

    This paper summarizes the work performed in a cooperative program on transportation technology between the Department of Energy (DOE) and the Power Reactor and Nuclear Fuel Development Corporation (PNC) of Japan. This work was performed at Sandia National Laboratories (SNL) in Albuquerque, New Mexico. The joint program emphasized the safety analysis for truck transportation of special nuclear materials (SNM) in Japan. Tasks included structural analyses and testing, thermal testing, leak rate studies and tests, and transportation risk assessments. The purpose of this paper is to present the results of full-scale structural and thermal tests conducted on a PNC development SNM transport system. Correlation of full-scale impact test results with structural analysis and scale model testing will also be reviewed

  14. 75 FR 28554 - Elimination of Classification Requirement in the Green Technology Pilot Program

    Science.gov (United States)

    2010-05-21

    ...] Elimination of Classification Requirement in the Green Technology Pilot Program AGENCY: United States Patent... (USPTO) implemented the Green Technology Pilot Program on December 8, 2009, which permits patent... technologies. However, the pilot program was limited to only applications classified in a number of U.S...

  15. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

    Science.gov (United States)

    2010-07-01

    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

  16. Parent-completed developmental screening in premature children: a valid tool for follow-up programs.

    Directory of Open Access Journals (Sweden)

    Cyril Flamant

    Full Text Available Our goals were to (1 validate the parental Ages and Stages Questionnaires (ASQ as a screening tool for psychomotor development among a cohort of ex-premature infants reaching 2 years, and (2 analyse the influence of parental socio-economic status and maternal education on the efficacy of the questionnaire. A regional population of 703 very preterm infants (<35 weeks gestational age born between 2003 and 2006 were evaluated at 2 years by their parents who completed the ASQ, by a pediatric clinical examination, and by the revised Brunet Lezine psychometric test with establishment of a DQ score. Detailed information regarding parental socio-economic status was available for 419 infants. At 2 years corrected age, 630 infants (89.6% had an optimal neuromotor examination. Overall ASQ scores for predicting a DQ score ≤85 produced an area under the receiver operator curve value of 0.85 (95% Confidence Interval:0.82-0.87. An ASQ cut-off score of ≤220 had optimal discriminatory power for identifying a DQ score ≤85 with a sensitivity of 0.85 (95%CI:0.75-0.91, a specificity of 0.72 (95%CI:0.69-0.75, a positive likelihood ratio of 3, and a negative likelihood ratio of 0.21. The median value for ASQ was not significantly associated with socio-economic level or maternal education. ASQ is an easy and reliable tool regardless of the socio-economic status of the family to predict normal neurologic outcome in ex-premature infants at 2 years of age. ASQ may be beneficial with a low-cost impact to some follow-up programs, and helps to establish a genuine sense of parental involvement.

  17. Developmental Programming: Does Prenatal Steroid Excess Disrupt the Ovarian VEGF System in Sheep?1

    Science.gov (United States)

    Ortega, Hugo Héctor; Veiga-Lopez, Almudena; Sreedharan, Shilpa; del Luján Velázquez, Melisa María; Salvetti, Natalia Raquel; Padmanabhan, Vasantha

    2015-01-01

    Prenatal testosterone (T), but not dihydrotestosterone (DHT), excess disrupts ovarian cyclicity and increases follicular recruitment and persistence. We hypothesized that the disruption in the vascular endothelial growth factor (VEGF) system contributes to the enhancement of follicular recruitment and persistence in prenatal T-treated sheep. The impact of T/DHT treatments from Days 30 to 90 of gestation on VEGFA, VEGFB, and their receptor (VEGFR-1 [FLT1], VEGFR-2 [KDR], and VEGFR-3 [FLT4]) protein expression was examined by immunohistochemistry on Fetal Days 90 and 140, 22 wk, 10 mo (postpubertal), and 21 mo (adult) of age. Arterial morphometry was performed in Fetal Day 140 and postpubertal ovaries. VEGFA and VEGFB expression were found in granulosa cells at all stages of follicular development with increased expression in antral follicles. VEGFA was present in theca interna, while VEGFB was present in theca interna/externa and stromal cells. All three receptors were expressed in the granulosa, theca, and stromal cells during all stages of follicular development. VEGFR-3 increased with follicular differentiation with the highest level seen in the granulosa cells of antral follicles. None of the members of the VEGF family or their receptor expression were altered by age or prenatal T/DHT treatments. At Fetal Day 140, area, wall thickness, and wall area of arteries from the ovarian hilum were larger in prenatal T- and DHT-treated females, suggestive of early androgenic programming of arterial differentiation. This may facilitate increased delivery of endocrine factors and thus indirectly contribute to the development of the multifollicular phenotype. PMID:26178718

  18. Developmental Programming: Does Prenatal Steroid Excess Disrupt the Ovarian VEGF System in Sheep?

    Science.gov (United States)

    Ortega, Hugo Héctor; Veiga-Lopez, Almudena; Sreedharan, Shilpa; del Luján Velázquez, Melisa María; Salvetti, Natalia Raquel; Padmanabhan, Vasantha

    2015-09-01

    Prenatal testosterone (T), but not dihydrotestosterone (DHT), excess disrupts ovarian cyclicity and increases follicular recruitment and persistence. We hypothesized that the disruption in the vascular endothelial growth factor (VEGF) system contributes to the enhancement of follicular recruitment and persistence in prenatal T-treated sheep. The impact of T/DHT treatments from Days 30 to 90 of gestation on VEGFA, VEGFB, and their receptor (VEGFR-1 [FLT1], VEGFR-2 [KDR], and VEGFR-3 [FLT4]) protein expression was examined by immunohistochemistry on Fetal Days 90 and 140, 22 wk, 10 mo (postpubertal), and 21 mo (adult) of age. Arterial morphometry was performed in Fetal Day 140 and postpubertal ovaries. VEGFA and VEGFB expression were found in granulosa cells at all stages of follicular development with increased expression in antral follicles. VEGFA was present in theca interna, while VEGFB was present in theca interna/externa and stromal cells. All three receptors were expressed in the granulosa, theca, and stromal cells during all stages of follicular development. VEGFR-3 increased with follicular differentiation with the highest level seen in the granulosa cells of antral follicles. None of the members of the VEGF family or their receptor expression were altered by age or prenatal T/DHT treatments. At Fetal Day 140, area, wall thickness, and wall area of arteries from the ovarian hilum were larger in prenatal T- and DHT-treated females, suggestive of early androgenic programming of arterial differentiation. This may facilitate increased delivery of endocrine factors and thus indirectly contribute to the development of the multifollicular phenotype. © 2015 by the Society for the Study of Reproduction, Inc.

  19. Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension.

    Science.gov (United States)

    Song, Renfang; Kidd, Laura; Janssen, Adam; Yosypiv, Ihor V

    2018-04-01

    Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells (NPCs) of the cap mesenchyme (CM) and the ureteric bud (UB). The prorenin receptor (PRR) is a receptor for renin and prorenin, and an accessory subunit of the vacuolar proton pump V-ATPase. Previously, we demonstrated that conditional ablation of the PRR in Six2 + NPCs in mice (Six2 PRR -/- ) causes early neonatal death. Here, we identified genes that are regulated by PRR in Six2 + NPCs FACS-isolated from Six2 PRR -/- and control kidneys on embryonic day E15.5 using whole-genome expression analysis. Seven genes with expression in CM cells previously shown to direct kidney development, including Notch1, β-catenin, Lef1, Lhx1, Jag1, and p53, were downregulated. The functional groups within the downregulated gene set included genes involved in embryonic and cellular development, renal regeneration, cellular assembly and organization, cell morphology, death and survival. Double-transgenic Six2 PRR -/- /BatGal + mice, a reporter strain for β-catenin transcriptional activity, showed decreased β-catenin activity in the UB in vivo. Reduced PRR gene dosage in heterozygous Six2 PRR +/- mice was associated with decreased glomerular number, segmental thickening of the glomerular basement membrane with focal podocyte foot process effacement, development of hypertension and increased soluble PRR (sPRR) levels in the urine at 2 months of age. Together, these data demonstrate that NPC PRR performs essential functions during nephrogenesis via control of hierarchy of genes that regulate critical cellular processes. Both reduced nephron endowment and augmented urine sPRR likely contribute to programming of hypertension in Six2 PRR +/- mice. © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  20. Nuclear electric propulsion for planetary science missions: NASA technology program planning

    International Nuclear Information System (INIS)

    Doherty, M.P.

    1993-01-01

    This paper presents the status of technology program planning to achieve readiness of Nuclear Electric Propulsion technologies needed to meet the advanced propulsion system requirements for planetary science missions in the next century. The technology program planning is based upon technologies of significant maturity: ion electric propulsion and the SP-100 space nulcear power technologies. Detailed plans are presented herein for the required ion electric propulsion technology development and demonstration. Closer coordination between space nuclear power and space electric propulsion technology programs is a necessity as technology plans are being further refined in light of NEP concept definition and possible early NEP flight activities