Instrumental Genesis in Technology-Mediated Learning: From Double Stimulation to Expansive Knowledge Practices

Science.gov (United States)

Ritella, Giuseppe; Hakkarainen, Kai

2012-01-01

The purpose of the present paper is to examine the socio-cultural foundations of technology-mediated collaborative learning. Toward that end, we discuss the role of artifacts in knowledge-creating inquiry, relying on the theoretical ideas of Carl Bereiter, Merlin Donald, Pierre Rabardel, Keith Sawyer and L. S. Vygotsky. We argue that epistemic…

Technology-Mediated Interventions and Quality of Life for Persons Living with HIV/AIDS. A Systematic Review.

Science.gov (United States)

Cho, Hwayoung; Iribarren, Sarah; Schnall, Rebecca

2017-04-12

As HIV/AIDS is considered a chronic disease; quality of life (QoL) has become an important focus for researchers and healthcare providers. Technology-mediated interventions have demonstrated improved clinical effectiveness in outcomes, such as viral suppression, for persons living with HIV/AIDS (PLWH). However, the evidence to support the impact of these interventions on QoL is lacking. The aim of this paper was to assess the impact of technology-mediated interventions on QoL and to identify the instruments used to measure the QoL of PLWH. For this review we followed the PRISMA guidelines. A literature search was conducted in PubMed, CINAHL, Cochrane, and EMBASE databases in April 2016. Inclusion criteria limited articles to those with technology-mediated interventions as compared to usual care; articles with the population defined as HIV-infected patients; and articles with QoL measured as a health outcome in randomized controlled trials. The Cochrane Collaboration Risk of Bias Tool was used to assess study quality. Of the 1,554 peer-reviewed articles returned in the searches, 10 met the inclusion criteria. This systematic review identified four types of technology-mediated interventions and two types of QoL instruments used to examine the impact of technology-mediated interventions on PLWH. Four studies of technology-mediated interventions resulted in improvement in QoL. Four studies considered QoL as a secondary outcome and resulted in a negative or neutral impact on QoL. Overall, four studies had a low risk of bias, one study had a moderate risk of bias, and the other five studies had a high risk of bias. The evidence to support the improvement of QoL using technology-mediated interventions is insufficient. This lack of research highlights the need for increased study of QoL as an outcome measure and the need for consistent measures to better understand the role of technology-mediated interventions in improving QoL for PLWH.

A social-technological epistemology of clinical decision-making as mediated by imaging.

Science.gov (United States)

van Baalen, Sophie; Carusi, Annamaria; Sabroe, Ian; Kiely, David G

2017-10-01

In recent years there has been growing attention to the epistemology of clinical decision-making, but most studies have taken the individual physicians as the central object of analysis. In this paper we argue that knowing in current medical practice has an inherently social character and that imaging plays a mediating role in these practices. We have analyzed clinical decision-making within a medical expert team involved in diagnosis and treatment of patients with pulmonary hypertension (PH), a rare disease requiring multidisciplinary team involvement in diagnosis and management. Within our field study, we conducted observations, interviews, video tasks, and a panel discussion. Decision-making in the PH clinic involves combining evidence from heterogeneous sources into a cohesive framing of a patient, in which interpretations of the different sources can be made consistent with each other. Because pieces of evidence are generated by people with different expertise and interpretation and adjustments take place in interaction between different experts, we argue that this process is socially distributed. Multidisciplinary team meetings are an important place where information is shared, discussed, interpreted, and adjusted, allowing for a collective way of seeing and a shared language to be developed. We demonstrate this with an example of image processing in the PH service, an instance in which knowledge is distributed over multiple people who play a crucial role in generating an evaluation of right heart function. Finally, we argue that images fulfill a mediating role in distributed knowing in 3 ways: first, as enablers or tools in acquiring information; second, as communication facilitators; and third, as pervasively framing the epistemic domain. With this study of clinical decision-making in diagnosis and treatment of PH, we have shown that clinical decision-making is highly social and mediated by technologies. The epistemology of clinical decision-making needs

Sonic mediations: body, sound, technology

NARCIS (Netherlands)

Birdsall, C.; Enns, A.

2008-01-01

Sonic Mediations: Body, Sound, Technology is a collection of original essays that represents an invaluable contribution to the burgeoning field of sound studies. While sound is often posited as having a bridging function, as a passive in-between, this volume invites readers to rethink the concept of

Technological Mediation and Power: Postphenomenology, Critical Theory, and Autonomist Marxism

NARCIS (Netherlands)

Bantwal Rao, M.; Jongerden, J.P.; Lemmens, P.C.; Ruivenkamp, G.T.P.

2015-01-01

This article focuses on the power of technological mediation from the point of view of autonomist Marxism (Hardt, Negri, Virno, Berardi, Lazzarrato). The first part of the article discusses the theories developed on technological mediation in postphenomenology (Ihde, Verbeek) and critical theory of

Role stress and turnover intentions among information technology personnel in South Africa: The role of supervisor support

Directory of Open Access Journals (Sweden)

Rennie Naidoo

2018-04-01

Full Text Available Orientation: High turnover of information technology (IT personnel is a major problem facing many global and local organisations. An increasingly important area of turnover research of IT personnel experiencing role stress involves examining their perceptions of supervisor support. Research purpose: This study aimed to examine the effects of role-related stress and supervisor support on job satisfaction, job performance and IT turnover intentions. Motivations for the study: It is important to assess from both a theoretical and a practical perspective the extent to which turnover can be explained by relational factors such as supervisor support. Research design, approach and method: An online voluntary survey yielded a sample of 163 respondents. Six constructs were measured: turnover intention, job performance, job satisfaction, supervisor support, role ambiguity and role conflict. A total of 158 usable responses were subjected to descriptive, correlation and regression analysis. Mediation and moderation effects were assessed using a multiple regression bootstrapping procedure. Main findings: Role ambiguity has a greater impact on job satisfaction than role conflict. Job satisfaction fully mediated the relationship between role stress and turnover intention. Supervisor support mediated the relationship between role stressors and job satisfaction and role stressors and job performance. There was no evidence in favour of a moderating role of supervisor support. Practical and managerial implications: Higher priority should be given to tackling role ambiguity. Supervisor support can increase job satisfaction, improve job performance and ultimately reduce turnover intentions, despite the presence of role stress. Contribution or value-add: Human resource managers and IT managers could use these results to improve job performance and staff retention.

The Mediator complex of Caenorhabditis elegans: insights into the developmental and physiological roles of a conserved transcriptional coregulator.

Science.gov (United States)

Grants, Jennifer M; Goh, Grace Y S; Taubert, Stefan

2015-02-27

The Mediator multiprotein complex ('Mediator') is an important transcriptional coregulator that is evolutionarily conserved throughout eukaryotes. Although some Mediator subunits are essential for the transcription of all protein-coding genes, others influence the expression of only subsets of genes and participate selectively in cellular signaling pathways. Here, we review the current knowledge of Mediator subunit function in the nematode Caenorhabditis elegans, a metazoan in which established and emerging genetic technologies facilitate the study of developmental and physiological regulation in vivo. In this nematode, unbiased genetic screens have revealed critical roles for Mediator components in core developmental pathways such as epidermal growth factor (EGF) and Wnt/β-catenin signaling. More recently, important roles for C. elegans Mediator subunits have emerged in the regulation of lipid metabolism and of systemic stress responses, engaging conserved transcription factors such as nuclear hormone receptors (NHRs). We emphasize instances where similar functions for individual Mediator subunits exist in mammals, highlighting parallels between Mediator subunit action in nematode development and in human cancer biology. We also discuss a parallel between the association of the Mediator subunit MED12 with several human disorders and the role of its C. elegans ortholog mdt-12 as a regulatory hub that interacts with numerous signaling pathways. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Communicating about the risks and benefits of genetically modified foods: The mediating role of trust

DEFF Research Database (Denmark)

Frewer, Lynn J.; Scholderer, Joachim; Bredahl, Lone

2003-01-01

Recent research suggests that public attitudes towards emerging technologies are mainly driven by trust in the institutions promoting and regulating these technologies. Alternative views maintain that trust should be seen as a consequence rather than a cause of such attitudes. To test its actual...... role, direct as well as mediating effects of trust were tested in an attitude change experiment involving 1203 consumers from Denmark, Germany, Italy and the UK. After prior attitudes to genetic modification in food production had been assessed, participants received different information materials...... an industry association, a consumer organization, or a government source). After completion, perceived risk and perceived benefit were assessed, and participants indicated their trust in the information sources to which the materials had been attributed. Direct and trust-mediated attitude change effects were...

Teaching Responsibly with Technology-Mediated Communication

Science.gov (United States)

Veltsos, Jennifer R.; Veltsos, Christophe

2010-01-01

Technology-mediated communication, or "new media," such as blogs, Twitter, wikis, and social network sites, can be an endless source of ideas for activities or inspiration for classroom discussion. Many instructors ask students to monitor current events by following keywords and industry leaders on Twitter and reading both corporate and…

Technification as an approach to realization of The child-friendly justice concept in terms of technologies of mediation and restorative justice: theory and practice questions

Directory of Open Access Journals (Sweden)

Sadovnikova M. N.

2017-01-01

Full Text Available Author of the article describes the "Technification", and report about its role in resolving the conflicts that appears in a process of working with children. The article reports about social Technologies that can effect the problem of juvenile delinquency and prevent manifestation of deviation in children’s behavior. Author focuses on the special role of restorative approach and technology of mediation in process of working of specialists involved in prevention of delinquency of children. The article is devoted to the working problems of specialists involved in prevention of delinquency of children. The Author highlights the special role of "Technification" of key branches of the child-friendly justice concept as more effective approach. On the example of using restorative-mediation technologies the author proves the algorithm of technification and possibilities of its realization in practice. The author draws attention to the "Shire krug" technology as a way for correcting of juvenile delinquency problem.

Grounded in Theory: Immersing Preservice Teachers in Technology-Mediated Learning

Science.gov (United States)

DeGennaro, Donna

2010-01-01

The integration of technology into preservice teacher education continues to be emphasized as important. The hope is that if future teachers obtain technology skills they will design meaningful technology-mediated learning experiences for their students. However, gaining technology skills alone does not ensure the ability to envision and employ…

Moralizing Food Technology

DEFF Research Database (Denmark)

Coff, Christian Eyde

2015-01-01

Food technologies are common on many levels in society and used by both food professionals and consumers. Food technologies are not neutral. They inform and shape the behaviour of people. This paper presents a theoretical framework for analysing the mediating role of food technology and its...... influence on food ethics. Post-phenomenology and the idea of a technologically mediated morality are central theoretical approaches. Four elements are included in the analytical framework: perception, interpretation, intentionality, and mediated morality. The framework is applied to two cases; food safety...

Adherence to Technology-Mediated Insomnia Treatment: A Meta-Analysis, Interviews, and Focus Groups

OpenAIRE

Horsch, Corine; Lancee, Jaap; Beun, Robbert Jan; Neerincx, Mark A; Brinkman, Willem-Paul

2015-01-01

Background: Several technologies have been proposed to support the reduction of insomnia complaints. A user-centered assessment of these technologies could provide insight into underlying factors related to treatment adherence. Objective: Gaining insight into adherence to technology-mediated insomnia treatment as a solid base for improving those adherence rates by applying adherence-enhancing strategies. Methods: Adherence to technology-mediated sleep products was studied in three ways. First...

The Role of Artefacts in Presence Mediation

NARCIS (Netherlands)

Vyas, Dhaval; Tzovaras, D

2007-01-01

Approaches to support computer mediated communication (CMC) have predominantly relied on the face-to-face communication paradigm. However, interaction and coordination can also be supported by different technological artefacts. In fact, most researches [1, 2, 3] related to ethnomethodology have

The Mediating Role of Textbooks in High-Stakes Assessment Reform

Science.gov (United States)

Leung, Ching Yin; Andrews, Stephen

2012-01-01

Whenever high-stakes assessment/curriculum reforms take place, new textbooks appear on the market. These textbooks inevitably play a significant mediating role in the implementation of any reform and on teaching and learning. This paper reports on a small-scale study which attempts to investigate the role of textbooks in the mediation of a…

DMPD: Complement-mediated phagocytosis--the role of Syk. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 16754322 Complement-mediated phagocytosis--the role of Syk. Tohyama Y, Yamamura H. ...IUBMB Life. 2006 May-Jun;58(5-6):304-8. (.png) (.svg) (.html) (.csml) Show Complement-mediated phagocytosis-...-the role of Syk. PubmedID 16754322 Title Complement-mediated phagocytosis--the role of Syk. Authors Tohyama

Job security and work performance in Chinese employees: The mediating role of organisational identification.

Science.gov (United States)

Ma, Bing; Liu, Shanshi; Liu, Donglai; Wang, Hongchun

2016-04-01

This research focuses on investigating whether organisational identification mediates the effects of job security on in-role behaviour and extra-role behaviour and how these mediation mechanisms differ according to gender. Through analysing 212 supervisor-subordinate dyads from a Chinese air transportation group, the research indicated that organisational identification partially mediated the effect of job security on in-role behaviour and fully mediated the effect of job security on extra-role behaviour. A multi-group analysis also showed that there were significant differences between male and female employees in these relationships. In addition, moderated mediation analyses showed that gender moderated the indirect effects of job security on in-role behaviour and extra-role behaviour through organisational identification. Limitations and implications of these findings are discussed. © 2015 International Union of Psychological Science.

Dialectic Antidotes to Critics of the Technology Acceptance Model: Conceptual, Methodological, and Replication Treatments for Behavioural Modelling in Technology-Mediated Environments

Directory of Open Access Journals (Sweden)

Weng Marc Lim

2018-01-01

Full Text Available The technology acceptance model (TAM is a prominent and parsimonious conceptual lens that is often applied for behavioural modelling in technology-mediated environments. However, TAM has received a great deal of criticism in recent years. This article aims to address some of the most pertinent issues confronting TAM through a rejoinder that offers dialectic antidotes—in the form of conceptual, methodological, and replication treatments—to support the continued use of TAM to understand the peculiarities of user interactions with technology in technology-mediated environments. In doing so, this article offers a useful response to a common but often inadequately answered question about how TAM can continue to be relevant for behavioural modelling in contemporary technology-mediated environments.

Media violence and adolescents’ ADHD-related behaviors: The role of parental mediation.

NARCIS (Netherlands)

Nikkelen, Sanne W C; Vossen, H.G.M.; Piotrowski, J. T.; Valkenburg, Patti M.

2016-01-01

We examined the role of parental media mediation in the relationship between media violence and adolescents’ ADHD-related behaviors. Survey data from 1,017 adolescents (10–14 years) show that parents can play an important role in this relationship, depending on the media mediation strategies that

Digital technologies and their impact on Higher Education. The new mediations

Directory of Open Access Journals (Sweden)

Juan de Pablos Pons

2018-03-01

Full Text Available This work proposes a reflection on the evolution of media in the digital age, requires us to advance in knowledge about mediation and remediation processes, favored by technologies, differentiating them from those generated so far by traditional analogue media (printed book, film, television. Digitization has given rise to new realities and proposals, such as video games, social networks or augmented reality applications. The next step in our media culture is the multiplication and continuous diversification of formats, but also new forms of mediated interaction. The mediation processes generated contribute to the modification of communication models and teaching methods. And this has an impact on educational institutions, and also on higher education. As a contribution to its analysis, the concept of technological remediation is provided and defined. The new information and communication technologies (ICT represent, under the considerations formulated here, an opportunity for change some forms and procedures of main areas of the higher education: teaching, research and management. Being proactive in this new reality is relevant, since the adaptation effort is linked to the survival of the university itself.

Role of MicroRNAs in Renin-Angiotensin-Aldosterone System-Mediated Cardiovascular Inflammation and Remodeling

Directory of Open Access Journals (Sweden)

Maricica Pacurari

2015-01-01

Full Text Available MicroRNAs are endogenous regulators of gene expression either by inhibiting translation or protein degradation. Recent studies indicate that microRNAs play a role in cardiovascular disease and renin-angiotensin-aldosterone system- (RAAS- mediated cardiovascular inflammation, either as mediators or being targeted by RAAS pharmacological inhibitors. The exact role(s of microRNAs in RAAS-mediated cardiovascular inflammation and remodeling is/are still in early stage of investigation. However, few microRNAs have been shown to play a role in RAAS signaling, particularly miR-155, miR-146a/b, miR-132/122, and miR-483-3p. Identification of specific microRNAs and their targets and elucidating microRNA-regulated mechanisms associated RAS-mediated cardiovascular inflammation and remodeling might lead to the development of novel pharmacological strategies to target RAAS-mediated vascular pathologies. This paper reviews microRNAs role in inflammatory factors mediating cardiovascular inflammation and RAAS genes and the effect of RAAS pharmacological inhibition on microRNAs and the resolution of RAAS-mediated cardiovascular inflammation and remodeling. Also, this paper discusses the advances on microRNAs-based therapeutic approaches that may be important in targeting RAAS signaling.

The role of mediation in resolving workplace relationship conflict.

Science.gov (United States)

McKenzie, Donna Margaret

2015-01-01

Stress triggered by workplace-based interpersonal conflict can result in damaged relationships, loss of productivity, diminished job satisfaction and increasingly, workers' compensation claims for psychological injury. This paper examined the literature on the role and effectiveness of mediation, as the most common method of Alternative Dispute Resolution, in resolving workplace relationship conflict. Available evidence suggests that mediation is most effective when supported by organisational commitment to ADR strategies, policies and processes, and conducted by independent, experienced and qualified mediators. The United States Postal Service program REDRESS™ is described as an illustration of the successful use of mediation to resolve conflict in the workplace. Copyright © 2015 Elsevier Ltd. All rights reserved.

Student Views of Technology-Mediated Written Corrective Feedback

DEFF Research Database (Denmark)

Kjærgaard, Hanne Wacher

2017-01-01

and practices concerning the specific – and time-consuming – language-teacher activity of providing WCF and 2) potential changes in student attitudes when technology is used to mediate the feedback. At the core of the study is an eight-month intervention which was carried out with three teachers of English...

Adherence to Technology-Mediated Insomnia Treatment: A Meta-Analysis, Interviews, and Focus Groups.

Science.gov (United States)

Horsch, Corine; Lancee, Jaap; Beun, Robbert Jan; Neerincx, Mark A; Brinkman, Willem-Paul

2015-09-04

Several technologies have been proposed to support the reduction of insomnia complaints. A user-centered assessment of these technologies could provide insight into underlying factors related to treatment adherence. Gaining insight into adherence to technology-mediated insomnia treatment as a solid base for improving those adherence rates by applying adherence-enhancing strategies. Adherence to technology-mediated sleep products was studied in three ways. First, a meta-analysis was performed to investigate adherence rates in technology-mediated insomnia therapy. Several databases were queried for technology-mediated insomnia treatments. After inclusion and exclusion steps, data from 18 studies were retrieved and aggregated to find an average adherence rate. Next, 15 semistructured interviews about sleep-support technologies were conducted to investigate perceived adherence. Lastly, several scenarios were written about the usage of a virtual sleep coach that could support adherence rates. The scenarios were discussed in six different focus groups consisting of potential users (n=15), sleep experts (n=7), and coaches (n=9). From the meta-analysis, average treatment adherence appeared to be approximately 52% (95% CI 43%-61%) for technology-mediated insomnia treatments. This means that, on average, half of the treatment exercises were not executed, suggesting there is a substantial need for adherence and room for improvement in this area. However, the users in the interviews believed they adhered quite well to their sleep products. Users mentioned relying on personal commitment (ie, willpower) for therapy adherence. Participants of the focus groups reconfirmed their belief in the effectiveness of personal commitment, which they regarded as more effective than adherence-enhancing strategies. Although adherence rates for insomnia interventions indicate extensive room for improvement, users might not consider adherence to be a problem; they believe willpower to be an

The mediating role of organizational subcultures in health care organizations.

Science.gov (United States)

Lok, Peter; Rhodes, Jo; Westwood, Bob

2011-01-01

This study aims to investigate the mediating role of organizational subculture between job satisfaction, organizational commitment (dependent variables) and leadership, culture (independent variables) in health care organizations. A survey on nurses from 26 wards from various types of hospital was used. A total of 251 usable returns were collected for the analysis (i.e. response rate of 63 per cent). Structural equation analysis was conducted to obtain the best fit model and to determine the direction of the causal effect between job satisfaction and commitment, and the role of subculture as a mediating variable, between commitment of its other antecedents. Comparisons with alternative models confirmed satisfaction as an antecedent of commitment and the role of subculture as a mediating variable. The results of this study contribute to the clarification of the causal relations of the antecedents of commitment, and highlight the important role of local leadership and subculture in determining employees' job satisfaction and commitment. The results of this study should not be generalized to other industries and other national cultural context. Furthermore, a longitudinal study may be necessary to determine the causal relationship of variables used in this study. The findings could provide managers with valuable insight to focus their limited resources on improving the level of organizational commitment via the mediating role of organizational culture. The research findings provide managers with a new lens to examine organizational culture using the three perspectives of: bureaucratic, supportive, and innovative. Furthermore, the results could renew interest in developing other organizational subculture models that determine the relationship between organizational subculture and commitment

The moderator-mediator role of social support in early adolescents.

Science.gov (United States)

Yarcheski, A; Mahon, N E

1999-10-01

The purpose of this study was to examine social support as both a mediator and a moderator of the relationship between perceived stress and symptom patterns in early adolescents. Data were collected from 148 early adolescent boys and girls, ages 12 to 14, who responded to the Perceived Stress Scale, the Personal Resource Questionnaire 85-Part II, and the Symptom Pattern Scale. Using multiple regression analysis procedures specified for the testing of moderation and mediation, results indicated that social support did not play a moderating role in the relationship between perceived stress and symptom patterns, but social support did play a mediating role in this relationship. The findings are interpreted within the two major theoretical orientations that guided the study.

STAT6: its role in interleukin 4-mediated biological functions.

Science.gov (United States)

Takeda, K; Kishimoto, T; Akira, S

1997-05-01

Interleukin (IL) 4 is known to be a cytokine which plays a central role in the regulation of immune response. Studies on cytokine signal transduction have clarified the mechanism by which IL4 exerts its functions. Two cytoplasmic proteins, signal transducer and activator of transcription (STAT) 6 and IL4-induced phosphotyrosine substrate/insulin receptor substrate 2 (4PS/IRS2), are activated in IL4 signal transduction. Recent studies from STAT6-deficient mice have revealed the essential role of STAT6 in IL4-mediated biological actions. In addition, STAT6 has also been demonstrated to be important for the functions mediated by IL13, which is related to IL4. IL4 and IL13 have been shown to induce the production of IgE, which is a major mediator in an allergic response. These findings indicate that STAT6 activation is involved in IL4- and IL13-mediated disorders such as allergy.

Moralizing Food Technology

DEFF Research Database (Denmark)

Coff, Christian Eyde

2015-01-01

Food technologies are common on many levels in society and used by both food professionals and consumers. Food technologies are not neutral. They inform and shape the behaviour of people. This paper presents a theoretical framework for analysing the mediating role of food technology and its influ...

Core Self-Evaluations and Job and Life Satisfaction: The Mediating and Moderated Mediating Role of Job Insecurity.

Science.gov (United States)

Hsieh, Hui-Hsien; Huang, Jie-Tsuen

2017-04-03

This study examined the mediating role of job insecurity in the relationship between core self-evaluations (CSE) and job satisfaction, while also investigating the moderating role of job insecurity in the mediated relationship between CSE and life satisfaction via job satisfaction. Survey data were collected from a sample of 346 full-time employees in Taiwan. We found that job insecurity partially mediated the CSE-job satisfaction relationship. Moreover, we found that job insecurity moderated not only the relationship between CSE and job satisfaction but also the mediated relationship between CSE and life satisfaction via job satisfaction. Specifically, both the CSE-job satisfaction relationship and the CSE-job satisfaction-life satisfaction relationship became stronger when job insecurity was low. Our results emphasize the importance of raising employees' CSE, which is beneficial not only for diminishing their perceptions of job insecurity, but also for boosting their job and life satisfaction. Practical implications and directions for future research are discussed.

Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

Science.gov (United States)

Yi, Young-Su; Son, Young-Jin; Ryou, Chongsuk; Sung, Gi-Ho; Kim, Jong-Hoon; Cho, Jae Youl

2014-01-01

Inflammation is a series of complex biological responses to protect the host from pathogen invasion. Chronic inflammation is considered a major cause of diseases, such as various types of inflammatory/autoimmune diseases and cancers. Spleen tyrosine kinase (Syk) was initially found to be highly expressed in hematopoietic cells and has been known to play crucial roles in adaptive immune responses. However, recent studies have reported that Syk is also involved in other biological functions, especially in innate immune responses. Although Syk has been extensively studied in adaptive immune responses, numerous studies have recently presented evidence that Syk has critical functions in macrophage-mediated inflammatory responses and is closely related to innate immune response. This review describes the characteristics of Syk-mediated signaling pathways, summarizes the recent findings supporting the crucial roles of Syk in macrophage-mediated inflammatory responses and diseases, and discusses Syk-targeted drug development for the therapy of inflammatory diseases. PMID:25045209

Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

Directory of Open Access Journals (Sweden)

Young-Su Yi

2014-01-01

Full Text Available Inflammation is a series of complex biological responses to protect the host from pathogen invasion. Chronic inflammation is considered a major cause of diseases, such as various types of inflammatory/autoimmune diseases and cancers. Spleen tyrosine kinase (Syk was initially found to be highly expressed in hematopoietic cells and has been known to play crucial roles in adaptive immune responses. However, recent studies have reported that Syk is also involved in other biological functions, especially in innate immune responses. Although Syk has been extensively studied in adaptive immune responses, numerous studies have recently presented evidence that Syk has critical functions in macrophage-mediated inflammatory responses and is closely related to innate immune response. This review describes the characteristics of Syk-mediated signaling pathways, summarizes the recent findings supporting the crucial roles of Syk in macrophage-mediated inflammatory responses and diseases, and discusses Syk-targeted drug development for the therapy of inflammatory diseases.

Technology-Mediated Learning for Resilience

DEFF Research Database (Denmark)

Sandvik, Kjetil; Majchrzak, Tim; Busch, Peter André

, such as the successive outbreak of a pandemic. Due to the novelty of the topic, research particularly exists on theoretical aspects of resilience. Targeting learning – and thereby the local population – is a rather new emergence. To effectively reach, involve, and engage citizens, technology can play a key role. Based...... on four actual cases from communities we analyse the impact technology has on learning about resilience. We then scrutinize the effectiveness and propose future steps. Thereby, we seek to provide practical advice to local governments and to enrich the theory at the same time....

Adherence to technology-mediated insomnia treatment: a meta-analysis, interviews, and focus groups

NARCIS (Netherlands)

Horsch, C.; Lancee, J.; Beun, R.J.; Neerincx, M.A.; Brinkman, W.-P.

2015-01-01

Background: Several technologies have been proposed to support the reduction of insomnia complaints. A user-centered assessment of these technologies could provide insight into underlying factors related to treatment adherence. Objective: Gaining insight into adherence to technology-mediated

The dual role of external technology sourcing in technological exploration

DEFF Research Database (Denmark)

Vanhaverbeke, Wim; Li-Ying, Jason; van de Vrande, Vareska

2013-01-01

from non-partners, partners may play a role because of whom they know. That is, they inform the firm about technological opportunities beyond its corporate venturing network. The empirical analysis supports the dual role of venturing partners in facilitating the two types of explorative learning.......We refine the concept of boundary-spanning exploration, by making a distinction between explorative learning from partners and from non-partners (Partners are organizations with whom a focal firm has some kind of external venturing relations, i.e. technological alliances, corporate venturing...... capital, or M&As). These partners play a dual role: in explorative learning from partners, a firm teams up with external venturing partners to co-develop or transfer technology. Partners’ technology base (what they know) is driving explorative learning from partners. In contrast, in explorative learning...

In Silico Medicine: Social, Technological and Symbolic Mediation

Directory of Open Access Journals (Sweden)

Annamaria Carusi

2016-06-01

Full Text Available In silico medicine is still forging a road for itself in the current biomedical landscape. Discursively and rhetorically, it is using a three-way positioning, first, deploying discourses of personalised medicine, second, extending the 3Rs from animal to clinical research, and third, aligning its methods with experimental methods. The discursive and rhetorical positioning in promotions and statements of the programme gives us insight into the sociability of the scientific labour of advancing the programme. Its progress depends on complex social, institutional and technological conditions which are not external to its epistemology, but intricately interwoven with it. This article sets out to show that this is the case through an analysis of the process of computational modelling that is at the core of its epistemology. In this paper I show that the very notion of ‘model’ needs to be re-thought for in silico medicine (as indeed, for most forms of computational modelling, and propose a replacement, in the form of the ‘Model-Simulation-Experiment-System’ or MSE-system, which is simultaneously an epistemological, social and technological system. I argue that the MSE-system is radically mediated by social relations, technologies and symbolic systems. We need now to understand how such mediations operate effectively in the construction of robust MSE-systems.

The identity of functional diversity in communication mediated by technology

Directory of Open Access Journals (Sweden)

Carmen Montalba-Ocaña

2017-12-01

Full Text Available The subject matter of the research presented below gravitates on the ontological change imposed by technology in humans. In particular, development of assistive technologies applied to alternative communication systems represents an interesting example of how this technology works on the social relationships, communication, and how this mediation modifies the self-image and social image of the users. This study focuses on people with cerebral palsy or neuronal degenerative disease and the identity transformation suffering to be able to communicate with autonomous tech support. In this way, the hypotheses to be faced in this study are: technology (paradoxically humanizes.

Customer Satisfaction, Perceived Service Quality and Mediating Role of Perceived Value

OpenAIRE

Malik, Saif Ullah

2012-01-01

The main objective of this study is to first find out perceived service quality using SERVQUAL and then the role of perceived value as a mediating variable in the service sector of Pakistan. Both descriptive and inferential statistical techniques are used to analyze the effects of independent variables (i.e. perceived service quality) on customer satisfaction (dependent variable) and the role of mediating variable (i.e. perceived value). Stepwise regression analysis is used to examine the eff...

The Role of Innate Lymphoid Cells in Immune-Mediated Liver Diseases

Science.gov (United States)

Liu, Meifang; Zhang, Cai

2017-01-01

Innate lymphoid cells (ILCs) are a recently identified group of innate immune cells lacking antigen-specific receptors that can mediate immune responses and regulate tissue homeostasis and inflammation. ILCs comprise group 1 ILCs, group 2 ILCs, and group 3 ILCs. These ILCs usually localize at mucosal surfaces and combat pathogens by the rapid release of certain cytokines. However, the uncontrolled activation of ILCs can also lead to damaging inflammation, especially in the gut, lung, and skin. Although the physiological and pathogenic roles of ILCs in liver diseases have been attracting increasing attention recently, there has been no systematic review regarding the roles of ILCs in immune-mediated liver diseases. Here, we review the relationships between the ILC subsets and their functions in immune-mediated liver diseases, and discuss their therapeutic potential based on current knowledge about the functional roles of these cells in liver diseases. PMID:28659927

[The Relationship Between Marital Adjustment and Psychological Symptoms in Women: The Mediator Roles of Coping Strategies and Gender Role Attitudes].

Science.gov (United States)

Yüksel, Özge; Dağ, İhsan

2015-01-01

The aim of this study were to investigate the mediator role of coping strategies and gender roles attitudes on the relationship between women's marital adjustment and psychological symptoms. 248 married women participated in the study. Participants completed Marital Adjustment Scale, Ways of Coping Questionnaire, Brief Symptom Inventory, Gender Role Attitudes Scale and Demographic Information Form. Regression analyses revealed that Submissive (Sobel z= -2.47, prole on the relationship between marital relationship score and psychological symptom level. Also, having Egalitarian Gender Role Attitude effects the psychological symptoms in relation with the marital relationship, but it is seen that this effect is not higher enough to play a mediator role (Sobel z =-1.21, p>.05). Regression analysis showed that there is a statistically significant correlation between women's marital adjustment and their psychological symptoms, indicating that the marital adjustment decreases as the psychological symptoms increases. It is also found out that submissive and helpless coping approach have mediator roles in this relationship. Also, contrary to expectations, having egalitarian gender role attitude effects the psychological symptoms in relation with the marital relationship, but this effect does not seem to play a mediator role. It is thought that the effects of marriage and couple therapy approaches considering couples’s problem solving and coping styles should be examined in further studies.

Developing Course Materials for Technology-Mediated Chinese Language Learning

Science.gov (United States)

Kubler, Cornelius C.

2018-01-01

This article discusses principles involved in developing course materials for technology-mediated Chinese language learning, with examples from a new course designed to take into account the needs of distance and independent learners. Which learning environment is most efficient for a given learning activity needs to be carefully considered. It…

The Role of Social Support in Mediating Stress and Depression

Directory of Open Access Journals (Sweden)

Prashanth Talwar

2017-05-01

Full Text Available As important as it is to fully comprehend the relationship between stress and depression among university students, it is also vital to ascertain the role of perceived social support as an essential psychosocial factor for effectively delimiting the deleterious impact of stress exposure. As such, the current study aimed to examine whether perceived social support functioned as a mediating factor in the relationship between stress and depression among university students. Data was collected from undergraduate students of a public university in Sarawak, Malaysia. Information on demographics, depression, stress and perceived social support were collated through self-report questionnaires. Results revealed significant gender differences for perceived social support, wherein female students reported lower levels of social support compared to their counterparts. Mediation analysis portrayed that the association between stress and depression was partially accounted for, by the mediating role of perceived social support.

Technology as Mediation Tool for Improving Teaching Profession in Higher Education Practices

Science.gov (United States)

Altinay-Gazi, Zehra; Altinay-Aksal, Fahriye

2017-01-01

Technology became a mediation tool for forming information and developing skills is teacher education programs of higher education institutions because technological tools can be used for self-reflection of prospective teachers' teaching performances. Practical implementation of teacher education programmes is a part of quality indicator in higher…

Knowledge sharing and affective commitment: the mediating role of psychological ownership

DEFF Research Database (Denmark)

Li, Jian; Yuan, Ling; Ning, Lutao

2015-01-01

and key knowledge sharing, while KPO exerted a negative impact on both; common knowledge sharing was positively related to key knowledge sharing; the relationship between affective commitment and key knowledge sharing was multi-mediated by OPO and common knowledge sharing. Originality/value – OPO and KPO....../methodology/approach – This paper is an empirical study based on structural equation modelling, with a sample of 293 employees from 31 high-technology firms in China. Findings – The result indicated that affective commitment had a significant positive effect on OPO but no effect on KPO; OPO was positively related to both common......Purpose – The purpose of this paper is to investigate the meditating role of psychological ownership which includes both organisation-based psychological ownership (OPO) and knowledge-based psychological ownership (KPO) on the relationship between affective commitment and knowledge sharing. Design...

The mediation roles of discrepancy stress and self-esteem between masculine role discrepancy and mental health problems.

Science.gov (United States)

Yang, Xue; Lau, Joseph T F; Wang, Zixin; Ma, Yee-Ling; Lau, Mason C M

2018-08-01

Masculine role discrepancy and discrepancy stress occur when men perceive that they fail to live up to the ideal manhood derived from societal prescriptions. The present study examined the associations between masculine role discrepancy and two emotional and mental health problems (social anxiety and depressive symptoms), and potential mediation effects through discrepancy stress and self-esteem in a male general population. Based on random population-based sampling, 2000 male residents in Hong Kong were interviewed. Levels of masculine role discrepancy, discrepancy stress, self-esteem, social anxiety, and depressive symptoms were assessed by using validated scales. Results of structural equation modeling analysis indicated that the proposed model fit the sample well. (χ 2 (118) = 832.34, p masculine role discrepancy, discrepancy stress, and emotional/mental health problems. We found that discrepancy stress significantly mediated the association between masculine role discrepancy and social anxiety, while self-esteem significantly mediated the associations between masculine role discrepancy and both social anxiety and depression. Study limitations mainly included the cross-sectional design and reliance on self-reported questionnaires. The associations between masculine discrepancy and social anxiety/depressive symptoms among men may be explained by the increase in discrepancy stress and decrease in self-esteem. The findings suggest needs and directions for future research for the relationship between masculine role discrepancy and men's mental health, mechanisms involved, and interventions for improvement. Copyright © 2018. Published by Elsevier B.V.

Relationship of submissive behavior and cyberbullying/cybervictimization: The mediation role of gender

OpenAIRE

Adem Peker; Yüksel Eroğlu; Nihan Çitemel

2012-01-01

The purpose of this study is to investigate the mediating role of gender in relationship between submissive behavior and cyber bullying/cyber victimization. The sample included 193 female and 137 male. Data were obtained using Submissive Behavior Scale and Revized Cyberbullying Inventory and analyzed by SPSS 11.5. Hierarchical regression was used to explore the mediating role of gender in relationship between submissive behavior and cyber bullying/cyber victimization. According to result...

25 CFR 291.10 - What is the role of the mediator appointed by the Secretary?

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What is the role of the mediator appointed by the... ENTERPRISES CLASS III GAMING PROCEDURES § 291.10 What is the role of the mediator appointed by the Secretary? (a) The mediator must ask the Indian tribe and the State to submit their last best proposal for Class...

Mediated Effects of Technology Competencies and Experiences on Relations among Attitudes Towards Technology Use, Technology Ownership, and Self Efficacy about Technological Pedagogical Content Knowledge

Science.gov (United States)

Yerdelen-Damar, Sevda; Boz, Yezdan; Aydın-Günbatar, Sevgi

2017-08-01

This study examined the relations of preservice science teachers' attitudes towards technology use, technology ownership, technology competencies, and experiences to their self-efficacy beliefs about technological pedagogical content knowledge (TPACK). The present study also investigated interrelations among preservice teachers' attitudes towards technology use, technology ownership, technology competencies, and experiences. The participants of study were 665 elementary preservice science teachers (467 females, 198 males) from 7 colleges in Turkey. The proposed model based on educational technology literature was tested using structural equation modeling. The model testing results revealed that preservice teachers' technology competencies and experiences mediated the relation of technology ownership to their TPACK self efficacy beliefs. The direct relation of their possession of technology to their TPACK self efficacy beliefs was insignificant while the indirect relation through their technology competencies and experiences was significant. The results also indicated there were significant direct effects of preservice teachers' attitudes towards technology use, technology competencies, and experiences on their TPACK self efficacy beliefs.

Transforming Environmental Knowledge into Behavior: The Mediating Role of Environmental Emotions

Science.gov (United States)

Carmi, Nurit; Arnon, Sara; Orion, Nir

2015-01-01

The present study was based on the premise that environmental knowledge can drive environmental behavior only if it arouses environmental emotions. Using a structural equations modeling approach, we tested the direct, as well as the indirect (mediated) effects of knowledge on behavior and assessed the mediating role of environmental emotions. We…

Lifelong Learning in Artistic Context Mediated by Advanced Technologies

Science.gov (United States)

Ferrari, Mirella

2016-01-01

This research starts by analysing the current state of artistic heritage in Italy and studying some examples in Europe: we try to investigate the scope of non-formal learning in artistic context, mediated by advanced technology. The framework within which we have placed our investigation is that of lifelong learning and lifedeep learning. The…

EWOM and brand awareness impact on consumer purchase intention: Mediating role of brand image

Directory of Open Access Journals (Sweden)

Maryam Tariq

2017-03-01

Full Text Available The basic purpose of this research is to analyze the impact of electronic word of mouth (eWOM and brand awareness on customer purchase intention with the mediating role of brand image. The research is conducted to analyze the full or partial role of mediator on the said relationship. This research is basically conducted on customers of mobile users of Rawalpindi and Islamabad. To check this relationship a total of 300 questionnaires were floated in four universities of twin cities, of which 262 questionnaires with a response rate of 87.33% were received back on which mediation analysis has been performed. The results show full mediating impact of brand image on Electronic Word of Mouth (eWOM and customer purchase intention relationship, while partial mediating role of brand image on relationship of brand awareness and customer purchase intention has been observed. This research will help marketers in implementing better marketing techniques for boosting customers purchase intention.

The role of logbooks as mediators of engineering design work

DEFF Research Database (Denmark)

McAlpine, Hamish; Cash, Philip; Hicks, Ben

2017-01-01

Information transformation is key to engineering design work. However, research on how information management tools, and logbooks in particular, mediate this, is fragmented. We explore this via two studies (from which we confirm the central role of logbooks) and propose three modes of mediation...... are such a central and enduring medium. This synthesises and extends theory on mediation and information use in engineering design. Further, practical insights are derived for the development new information management tools.......: facilitating cognition and creation, gathering and collation of information, and staging and transformation of information. The findings explain the widespread use of logbooks through their support of these three modes. Consequently, we contend that multi-modal mediation is one of the main reasons why logbooks...

Theoretical Propositions for the Citizen Formation Mediated by Technology

Directory of Open Access Journals (Sweden)

Tania Margarita Martínez de Padrón

2018-02-01

Full Text Available The research presented emerges from the connotations concerning the formation of the citizenship by the information technology and communication. Be part of the conception of the current citizen and the influence that has emerged through the utility of the various social networks, as well as Canaima education project and the guidance provided to schoolchildren in this sense. The general objective was to generate propositions theoretical that guide the formation of citizenship mediated by ICT in the primary schools of Santa Teresa del Tuy. The methodology used was the qualitative paradigm, based on the interpretative phenomenological approach of Heidegger, which is interested in discovering and understanding the meanings, habits and practices of the human being. Castle (2000: 5. The researcher approached the field object of study to observe, describe and interpret a reality. As an instrument used the interview in depth. The information obtained was recorded in pictures which allowed to comply with the development of specific objectives through triangulation. On whose findings prevailed deviating from the use of technological tools and how these have formed the formation of citizenship in school children in their behavior and actions. At the same time, allowed know from educational technological approach, that sparing the teacher provides guidance that redirect the formation of citizenship. Also was the stated objective as it was the theoretical propositions that guide the formation of citizens ICT-mediated.

Interpreting instructional cues in task switching procedures: the role of mediator retrieval.

Science.gov (United States)

Logan, Gordon D; Schneider, Darryl W

2006-03-01

In 3 experiments the role of mediators in task switching with transparent and nontransparent cues was examined. Subjects switched between magnitude (greater or less than 5) and parity (odd or even) judgments of single digits. A cue-target congruency effect indicated mediator use: subjects responded faster to congruent cue-target combinations (e.g., ODD-3) than to incongruent cue-target combinations (e.g., ODD-4). Experiment 1 revealed significant congruency effects with transparent word cues (ODD, EVEN, HIGH, and LOW) and with relatively transparent letter cues (O, E, H, and L) but not with nontransparent letter cues (D, V, G, and W). Experiment 2 revealed significant congruency effects after subjects who were trained with nontransparent letter cues were informed of the relations between cues and word mediators halfway through the experiment. Experiment 3 showed that congruency effects with relatively transparent letter cues diminished over 10 sessions of practice, suggesting that subjects used mediators less as practice progressed. The results are discussed in terms of the role of mediators in interpreting instructional cues.

Music Technology-Mediated Teaching and Learning Approach for Music Education: A Case Study from an Elementary School in South Korea

Science.gov (United States)

Kim, Eunjin

2013-01-01

This study aims to show how music technology mediated (or music software mediated) music teaching and learning can provide an effective pedagogy in music education. It also seeks to demonstrate that music technology mediated teaching is in accordance with socio-educational trends for both postmodern values and IT mediated learning. The new…

Mediating and/or moderating roles of psychological empowerment.

Science.gov (United States)

Meng, Lina; Jin, Yi; Guo, Jiajia

2016-05-01

The purpose of this study was to explore the mediating and/or moderating effects of psychological empowerment in the relationship between structural empowerment and burnout among nurses in China. Burnout is prevalent among nurses. Previous studies have found that empowering organizational structures contribute to reduce nurses' burnout. However, little is known about the mediating or moderating role of psychological empowerment in the relationship between structural empowerment and burnout among nurses in China. A cross-sectional design was conducted. A total of 244 nurses participated in this study. The data were collected in March 2013. Multiple regressions were used to test the hypothesized models. Psychological empowerment was found to be a significant mediator of the relationship between structural empowerment and burnout (standardized β=-0.553, Sobel test: z=7.79, pmoderating effect of psychological empowerment in that relationship was not verified. Both structural and psychological empowerment negatively correlated with burnout. The psychological empowerment had a mediating effect on burnout. It is important for nurse managers to develop strategies to ensure that empowering structures are in place and to facilitate nurses' perception of psychological empowerment. Copyright © 2015 Elsevier Inc. All rights reserved.

Analyzing the effects of information technology on supply chain integration: The role of ERP success mediator

Directory of Open Access Journals (Sweden)

Samaneh Alimohamadian

2014-04-01

Full Text Available This research analyzes the effects of Information Technology (IT on Supply Chain Integration (SCI through ERP mediator by proposing a conceptual model among these components. We also hypothesize that three constructs of IT influence on enterprise resource planning (ERP success and one construct of ERP success influences on SCI. To clarify the relationships among the constructs, structural equation model (SEM is conducted to examine the model fit and seven hypotheses. The data was collected from three Iranian firms through questionnaire with 23 questions adopted by past researches. The results confirmed that top management support of IT and employees’ general IT skills factors of IT enhance ERP success, and ERP success positively influences on Supply Chain Integration, so these two IT factors influence Supply Chain Integration through ERP success. Our data unsupported negative impact of satisfaction with legacy IT system on ERP success.

The Role of New Technologies on Contemporary Communication

Directory of Open Access Journals (Sweden)

Tudor IOAN

2012-11-01

Full Text Available Human communication, in its various forms and systems of signs has allowed for the addition of cultural values along the course of human history, through their conservation and transmission from one generation to the next, a process which confers on culture its cumulative character. Information, specific to the human world, has, itself, a particular role. The information field, generalized, changes within us the feeling of time. Man’s relationship with nature, instead of being just lived, practiced in an obscure manner, gains a statute of stability, of consistency, which transforms it into a reality with its own laws and orderly permanence. Technical activity, edifying the world of technical objects and generalizing the objective mediation between man and nature, links man to nature through a connection that is much richer and well defined than that of the specific reaction of collective labor. The transformations of contemporary communication due to new technologies imply and insistently demand modifications especially in the area of human adaptability.

Examining the role of unmeasured confounding in mediation analysis with genetic and genomic applications.

Science.gov (United States)

Lutz, Sharon M; Thwing, Annie; Schmiege, Sarah; Kroehl, Miranda; Baker, Christopher D; Starling, Anne P; Hokanson, John E; Ghosh, Debashis

2017-07-19

In mediation analysis if unmeasured confounding is present, the estimates for the direct and mediated effects may be over or under estimated. Most methods for the sensitivity analysis of unmeasured confounding in mediation have focused on the mediator-outcome relationship. The Umediation R package enables the user to simulate unmeasured confounding of the exposure-mediator, exposure-outcome, and mediator-outcome relationships in order to see how the results of the mediation analysis would change in the presence of unmeasured confounding. We apply the Umediation package to the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study to examine the role of unmeasured confounding due to population stratification on the effect of a single nucleotide polymorphism (SNP) in the CHRNA5/3/B4 locus on pulmonary function decline as mediated by cigarette smoking. Umediation is a flexible R package that examines the role of unmeasured confounding in mediation analysis allowing for normally distributed or Bernoulli distributed exposures, outcomes, mediators, measured confounders, and unmeasured confounders. Umediation also accommodates multiple measured confounders, multiple unmeasured confounders, and allows for a mediator-exposure interaction on the outcome. Umediation is available as an R package at https://github.com/SharonLutz/Umediation A tutorial on how to install and use the Umediation package is available in the Additional file 1.

Economy and technology roles played by nuclear power

International Nuclear Information System (INIS)

Yamada, Eiji

1985-01-01

On the basis of the survey analysis made by Atomic Energy Commission on the roles in economy and technology played in the nuclear energy development and utilization, the following are described: economic roles in nuclear energy development and utilization (the present state of nuclear power industry in Japan and the economy effects); technological roles in the same (the present state of nuclear power technology in Japan and the technology effects). The economy effects in other areas are on higher level than in other industries etc. Then, in the technology effects, system technology and quality control in the nuclear power possess significant effects in other areas. While the nuclear energy development and utilization is important in Japan's energy security, it is contributing largely to the economy and society in Japan. (Mori, K.)

The best I can be: how self-accountability impacts product choice in technology mediated environments

OpenAIRE

Rowe, Zoe O.; Wilson, Hugh; Dimitriu, Radu; Breiter, Katja; Charnley, Fiona

2017-01-01

Technology-mediated environments are important not only as the location for an increasing proportion of purchases, but also as an even more pervasive part of the purchase journey. While most research into online consumer behavior focuses on attitudes as an antecedent of product choice, this article focuses on an important but hardly explored variable that may be impacted by technology-mediated environments: self-accountability. Laboratory experiments suggest that self-accountability may influ...

GEOGRAPHICAL EDUCATION MEDIATIZATION AND MEDIASECURITY ISSUES

Directory of Open Access Journals (Sweden)

M. R. Arpentieva

2017-01-01

Full Text Available The article is devoted to the interaction of legal and moral development of media technologies in the context of geographical education. The article summarizes the experience of the theoretical analysis of mediatization in geographic education, the legal and moral aspects of the disorders and ways of their prevention and correction in the process of educational interaction between teacher and student, between student and teacher, mediated mediatechnologies. It is noted that geographical education in the modern world is education, which is closely associated with the use of media technologies. In other types of education the role of media technologies in improving the quality of education is less obvious, in the field of teaching and learning geography, it speaks very clearly. Therefore, the problems associated with its mediatization, are very important and their solution is particularly compelling. These issues are primarily associated with actively flowing social, economic, political and ideological crisis in many communities and countries of the Earth. Many of them as in the “mirror” are reflected in the sphere of high technologies, including media technologies. The article provides guidance and direction to the correction of violations at the individual and social levels.

Publics in the making: mediating different methods of engagement and the publics these construct : commentary on: "Technologies of democracy: experiments and demonstrations".

Science.gov (United States)

Mohr, Alison

2011-12-01

The potential for public engagement to democratise science has come under increasing scrutiny amid concerns that conflicting motivations have led to confusion about what engagement means to those who mediate science and publics. This raises important yet relatively unexplored questions regarding how publics are constituted by different forms of engagement used by intermediary scholars and other actors. It is possible to identify at least two possible 'rationalities of mediation' that mobilise different versions of the public and the roles they are assumed to play, as 'citizens' or 'users', in discussions around technology. However, combinations of rationalities are found in practice and these have significant implications for the 'new' scientific democracy.

Authentic leadership and thriving among nurses: the mediating role of empathy.

Science.gov (United States)

Mortier, Anneleen Viona; Vlerick, Peter; Clays, Els

2016-04-01

To examine the relationship between perceived authentic leadership and two dimensions of thriving (learning and vitality) among nurses, and to study the mediating role of empathy in this relationship. Nurses' thriving is a key asset for health care organisations, and its significant role warrants the need to identify the underlying key determinants and psychological mechanisms. A cross-sectional design was carried out in a large hospital in September 2013. Self-administered questionnaires were distributed to 360 nurses. The main hypotheses were tested through hierarchical regression analyses. The significant positive relationship between perceived authentic leadership and vitality was mediated by perceived empathy. This mediation, however, was not confirmed in relation to learning. Nurse managers' authentic leadership enhances nurses' thriving at work. Furthermore, empathic nurse managers seem to increase the vitality of their nurses. Training nurse managers in authentic leadership skills is important for the nursing field, as those skills help nurse managers to better express empathy and consequently foster thriving in nursing. © 2015 John Wiley & Sons Ltd.

The Role of Histone Demethylase Jmjd3 in Immune-Mediated Aplastic Anemia

Science.gov (United States)

2017-03-01

AWARD NUMBER: W81XWH-16-1-0055 TITLE: The Role of Histone Demethylase Jmjd3 in Immune-Mediated Aplastic Anemia PRINCIPAL INVESTIGATOR: Yi...Immune-Mediated Aplastic Anemia 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-16-1-0055 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Yi Zhang 5d... anemia (AA) is a condition of bone marrow failure (BMF) characterized by blood pancytopenia and BM hypoplasia. In most cases, AA is an immune-mediated

Use of Information and Communication Technology (ICT) and Perceived Health in Adolescence: The Role of Sleeping Habits and Waking-Time Tiredness

Science.gov (United States)

Punamaki, Raija-Leena; Wallenius, Marjut; Nygard, Clase-Hakan; Saarni, Lea; Rimpela, Arja

2007-01-01

The first aim for this paper was to examine gender and age differences in the intensity of usage of information and communication technology (ICT: computer for digital playing, writing and e-mailing and communication, and Internet surfing, and mobile phone). Second, we modelled the possible mediating role of sleeping habits and waking-time…

Mediating the Maltreatment-Delinquency Relationship: The Role of Triad Gang Membership.

Science.gov (United States)

Chui, Wing Hong; Khiatani, Paul Vinod

2018-02-01

The primary aim of this article is to examine the role of triad affiliation in mediating the relationship between child maltreatment (neglect, punishment, emotional abuse, and sexual abuse) and delinquency among active young gang members in Hong Kong. A sample of 177 gang members aged 12 to 24 was recruited to complete a questionnaire with the assistance of a youth outreach social work team. Neglect was identified as the most common form of maltreatment, followed by emotional abuse, punishment, and sexual abuse. Mediation analyses confirmed that triad affiliation acts as a mediating variable in the child maltreatment-delinquency relationship, except in cases of sexual abuse. Only the relationship between punishment and delinquency was found to be fully mediated by triad affiliation; partial mediation effects were found for neglect and emotional abuse. Recommendations for child protection and youth workers are provided.

Internet-Mediated Technologies and Mixed Methods Research: Problems and Prospects

Science.gov (United States)

Hesse-Biber, Sharlene; Griffin, Amy J.

2013-01-01

This article provides an examination of a range of mixed methods research projects that employ Internet-mediated technologies (IMT) for data collection. Using a case study approach, this article allows for the uncovering of a process by which IMT are used as a data collection medium in mixed methods praxis. Under the theoretical position of medium…

Technology Mediated Instruction and its Effect on Cognitive Scaffolding, motivation and Academic Performance in EFL Context

Directory of Open Access Journals (Sweden)

Sepideh Berenji

2017-11-01

Full Text Available Technology mediated learning brings together the users with shared interests. This method makes learners informally engaged in language learning. This study intended to investigate the effect of technology mediated instruction on cognitive scaffolding, academic performance and motivation. Employing a quasi-experimental research, 80 learners from two intact classes at Islamic Azad University, Osku Branch were selected as the experimental and control groups. Telegram as a tool was used in the experimental group, while the control group received traditional way of instruction. Critical ethnography approach was implemented to consider the amount of cognitive scaffolding. To measure the students’ motivational level in both groups, Course Interest Survey (CIS was administered at the end of the semester. The total average score for each group was calculated. To compare students’ academic achievement, their average scores in the final academic test were considered. An Independent samples t-test in was used to compare the mean scores. The results indicated that technology mediated learning brought about cognitive scaffolding and the students in the experimental group outperformed the control group in terms of motivation and academic achievement. The results of the study suggest that to bring about academically successful students, practitioners should use technology mediated instruction.

Violence Exposure and Psychopathology in Urban Youth: The Mediating Role of Posttraumatic Stress

Science.gov (United States)

Ruchkin, Vladislav; Henrich, Christopher C.; Jones, Stephanie M.; Vermeiren, Robert; Schwab-Stone, Mary

2007-01-01

Understanding the mechanisms underlying the development of violence exposure sequelae is essential to providing effective treatments for traumatized youth. This longitudinal study examined the mediating role of posttraumatic stress in the relationship between violence exposure and psychopathology, and compared the mediated models by gender. Urban…

The mediational role of identification in the relationship between experience mode and self-efficacy: Enactive role-playing versus passive observation.

Science.gov (United States)

Peng, Wei

2008-12-01

Abstract Based on Social Cognitive Theory, this study proposes a new concept-mediated enactive experience to understand game playing effects on self-efficacy in the context of a health promotion role-playing game. An experiment demonstrated that a mediated enactive experience afforded by game playing was more effective than a mediated observational experience provided by game watching in influencing self-efficacy. It was found that identification with the game character partially mediated the relationship between experience mode and self-efficacy.

The mediating role of facebook fan pages.

Science.gov (United States)

Chih, Wen-Hai; Hsu, Li-Chun; Wang, Kai-Yu; Lin, Kuan-Yu

2014-01-01

Using the dual mediation hypothesis, this study investigates the role of interestingness (the power of attracting or holding one's attention) attitude towards the news, in the formation of Facebook Fan Page users' electronic word-of-mouth intentions. A total of 599 Facebook fan page users in Taiwan were recruited and structural equation modeling (SEM) was used to test the research hypotheses. The results show that both perceived news entertainment and informativeness positively influence interestingness attitude towards the news. Interestingness attitude towards the news subsequently influences hedonism and utilitarianism attitudes towards the Fan Page, which then influence eWOM intentions. Interestingness attitude towards the news plays a more important role than hedonism and utilitarianism attitudes in generating electronic word-of-mouth intentions. Based on the findings, the implications and future research suggestions are provided.

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.

Science.gov (United States)

Noerager, Brett D; Xu, Xin; Davis, Virginia A; Jones, Caleb W; Okafor, Svetlana; Whitehead, Alicia; Blalock, J Edwin; Jackson, Patricia L

2015-12-01

Neutrophils (PMNs) are key mediators of inflammatory processes throughout the body. In this study, we investigated the role of acrolein, a highly reactive aldehyde that is ubiquitously present in the environment and produced endogenously at sites of inflammation, in mediating PMN-mediated degradation of collagen facilitating proline-glycine-proline (PGP) production. We treated peripheral blood neutrophils with acrolein and analyzed cell supernatants and lysates for matrix metalloproteinase-9 (MMP-9) and prolyl endopeptidase (PE), assessed their ability to break down collagen and release PGP, and assayed for the presence of leukotriene A4 hydrolase (LTA4H) and its ability to degrade PGP. Acrolein treatment induced elevated production and functionality of collagen-degrading enzymes and generation of PGP fragments. Meanwhile, LTA4H levels and triaminopeptidase activity declined with increasing concentrations of acrolein thereby sparing PGP from enzymatic destruction. These findings suggest that acrolein exacerbates the acute inflammatory response mediated by neutrophils and sets the stage for chronic pulmonary and systemic inflammation.

A Multi-Case Study of University Students' Language-Learning Experience Mediated by Mobile Technologies: A Socio-Cultural Perspective

Science.gov (United States)

Ma, Qing

2017-01-01

Emerging mobile technologies can be considered a new form of social and cultural artefact that mediates people's language learning. This multi-case study investigates how mobile technologies mediate a group of Hong Kong university students' L2 learning, which serves as a lens with which to capture the personalised, unique, contextual and…

Risk Factors for Preschool Depression: The Mediating Role of Early Stressful Life Events

Science.gov (United States)

Luby, Joan L.; Belden, Andy C.; Spitznagel, Edward

2006-01-01

Background: Family history of mood disorders and stressful life events are both established risk factors for childhood depression. However, the role of mediators in risk trajectories, which are potential targets for intervention, remains understudied. To date, there have been no investigations of mediating relationships between risk factors and…

The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate Cancer.

Science.gov (United States)

Soekmadji, Carolina; Nelson, Colleen C

2015-01-01

Emerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs.

Reality check : the role of realism in stress reduction using media technology

NARCIS (Netherlands)

Kort, de Y.A.W.; IJsselsteijn, W.A.

2006-01-01

There is a growing interest in the use of virtual and other mediated environments for therapeutic purposes. However, in the domain of restorative environments, virtual reality (VR) technology has hardly been used. Here the tendency has been to use mediated real environments, striving for maximum

Technological mediation as a learning tool for writing and reading

Directory of Open Access Journals (Sweden)

Gladys Molano Caro

2015-12-01

Full Text Available This article disclosed the progress a technological mediation has built to the adquisition, use and development of reading and writing from Cognitive Affective Method for Learning -MACPA-. A development like the one being proposed, is an option for children and young people to, activate, promote, develop and / or enhance the learning of reading and writing. Likewise, it is an option to consider the results achieved in the PISA test and case reports, done by teachers by teachers, showing that that elementary students do not perform production of texts so spontaneous or directed; and they fail to make progress in reading comprehension levels. Given this context, the partial results achieved in the second phase of the research aims to implement a technology platform based mediation MACPA as an educational resource to enhance the processes of reading and writing among students from first to fourth grades of primary education. Accordingly, through Article basis be found in a software for reading and writing that takes into account the particularities of learning of students with intellectual disabilities, learning disabilities in students who have not evidenced difficulties in academic learning processes, though they require a new method to accelerate learning.

COUNTRY OF ORIGIN EFFECT ON ORGANIZATIONAL INNOVATION IN MALAYSIA: THE MEDIATING ROLE OF STRUCTURE

Directory of Open Access Journals (Sweden)

Aizzat Mohd. Nasurdin

2004-01-01

Full Text Available The two main objectives of this study are: first, to determine whether the level of innovation (technological and process, product and administrative varies by country of origin, and second, to investigate the influence of country of origin on organizational innovation (technological and process, product and administrative via the mediating role played by organizational structure (formalization and centralization, among firms operating in Malaysia. Statistical analyses of the 80 multinational corporations and 43 locally-owned firms and joint-ventures using ANOVA revealed that significant differences do exist in terms of their innovation levels. Firms from the West (American multinationals and European multinationals had higher levels of technological and process innovation compared to firms from the East (Eastern multinationals plus local companies and joint-ventures. Regarding product innovation, American multinationals were found to be more innovative compared to European multinationals and firms from the East (Eastern multinationals plus local firms and joint-ventures. In terms of administrative innovation, American multinationals were found to be most innovative followed by European multinationals, and lastly, firms from the East (Eastern multinationals plus local companies and joint-ventures. Additionally, country of origin had no indirect effect on the three forms of innovation via structure. Implications and suggestions for future research are discussed.

Maternal childhood abuse, intimate partner violence, and child psychopathology: the mediator role of mothers' mental health.

Science.gov (United States)

Miranda, Jenniffer K; de la Osa, Nuria; Granero, Roser; Ezpeleta, Lourdes

2013-01-01

This study examined the mediator role of mothers' mental health in the relationship among maternal childhood abuse (CA), intimate partner violence (IPV), and offspring's psychopathology, and explored whether mediational pathways were moderated by children's sex. Participants were 327 Spanish outpatient children, 8 to 17 years old, and their mothers. Mothers' global psychological distress and depressive symptoms mediated the associations between mothers' violence history and children's externalizing problems. However, only depressive symptoms fully mediated these relationships. Children's sex did not have a moderating role in adjusted paths. Mothers' depressive symptoms are an important mechanism by which maternal violence experiences could affect externalizing problems in Spanish children.

Core self-evaluation and burnout among Nurses: the mediating role of coping styles.

Science.gov (United States)

Li, Xiaofei; Guan, Lili; Chang, Hui; Zhang, Bo

2014-01-01

This study aimed to determine the potential association between core self-evaluation and the burnout syndrome among Chinese nurses, and the mediating role of coping styles in this relationship. A cross-sectional survey was conducted in Shenyang, China, from May to July, 2013. A questionnaire which consisted of the Maslach Burnout Inventory-General Survey (MBI-GS), the Core Self-Evaluation Scale (CSE), and the Simplified Coping Style Questionnaire (CSQ), was completed by a total of 1,559 nurses. Hierarchical linear regression analyses and the Sobel test were performed to determine the mediating role of coping styles on the relationship between CSE and burnout. Nurses who had higher self-evaluation characteristics, reported less emotional exhaustion and cynicism, and higher professional efficacy. Coping style had a partial mediating effect on the relationship between CSE and the burnout syndrome among nurses. Core self-evaluation had effects on burnout and coping style was a mediating factor in this relationship among Chinese nurses. Therefore, the improvement of coping strategies may be helpful in the prevention of burnout among nurses, thus enhancing professional performance.

From Mediatized Emotion to Digital Affect Cultures

OpenAIRE

Döveling, Katrin; Harju, Anu Annika; Sommer, Denise

2018-01-01

Research on the processes of mediatization aims to explore the mutual shaping of media and social life and how new media technologies influence and infiltrate social practices and cultural life. We extend this discussion of media’s role in transforming the everyday by including in the discussion the mediatization of emotion and discuss what we conceptualize as digital affect culture(s). We understand these as relational, contextual, globally emergent spaces in the digital environment where af...

How job demands affect absenteeism? The mediating role of work-family conflict and exhaustion.

Science.gov (United States)

Vignoli, Michela; Guglielmi, Dina; Bonfiglioli, Roberta; Violante, Francesco Saverio

2016-01-01

To investigate how psychosocial factors (such as job demands and work-family conflict) produce absenteeism in the workplace, using the health impairment process of the job demands-resources model. According to this model, job demands lead to burnout (often measured with the emotional exhaustion component), which in turn could lead to outcomes (such as absenteeism). Work-family conflict (WFC) was also studied, because of contradictory results collected in the existing literature on absenteeism in the workplace, regarding the role of WFC in causing absenteeism. Data were collected on 245 workers using both subjective (questionnaire on psychological risk factors and work-related health) and objective data (sickness leave frequency records). To test the hypothesis that job demands and WFC contribute to absenteeism in the workplace, a subsequent mediation analysis was used, which analysed both (a) the subsequent mediation of WFC and emotional exhaustion and (b) the separate roles played by the mediators proposed (WFC and emotional exhaustion). Job demands affect absenteeism through the subsequent mediation of WFC and emotional exhaustion. In addition, emotional exhaustion mediates the relationship between job demands and absenteeism, while WFC does not. In conclusion, subsequent mediation highlights the role of emotional exhaustion in causing absenteeism; in fact, when emotional exhaustion is included in the analysis, job demands are associated with higher levels of absenteeism. The results of this study suggest that without the concurrent contribution of emotional exhaustion, WFC does not influence absenteeism in the workplace. Our findings are useful for organizations that aim to reduce absenteeism.

Perceived Work Conditions and Turnover Intentions: The Mediating Role of Meaning of Work

Science.gov (United States)

Arnoux-Nicolas, Caroline; Sovet, Laurent; Lhotellier, Lin; Di Fabio, Annamaria; Bernaud, Jean-Luc

2016-01-01

Perceived working conditions lead to various negative outcomes for employee behaviors, including turnover intentions. Although potential mediators for these relationships were previously identified, the importance of meaning of work has not yet been investigated. This study examines the role of this psychological resource as a mediator for the relationships between perceived working conditions and turnover intentions in a sample of 336 French workers from different job contexts. Results show that adverse working conditions were positively and significantly associated with turnover intentions. Meaning of work is negatively related to both perceived working conditions and turnover intentions. Mediation analyses for meaning of work demonstrated indirect effects of several adverse working conditions on turnover intentions. The role of meaning of work as a psychological resource for employees facing adverse working conditions is discussed, especially regarding its implications for research and practice within organizational contexts. PMID:27242616

Perceived Work Conditions and Turnover Intentions: The Mediating Role of Meaning of Work.

Science.gov (United States)

Arnoux-Nicolas, Caroline; Sovet, Laurent; Lhotellier, Lin; Di Fabio, Annamaria; Bernaud, Jean-Luc

2016-01-01

Perceived working conditions lead to various negative outcomes for employee behaviors, including turnover intentions. Although potential mediators for these relationships were previously identified, the importance of meaning of work has not yet been investigated. This study examines the role of this psychological resource as a mediator for the relationships between perceived working conditions and turnover intentions in a sample of 336 French workers from different job contexts. Results show that adverse working conditions were positively and significantly associated with turnover intentions. Meaning of work is negatively related to both perceived working conditions and turnover intentions. Mediation analyses for meaning of work demonstrated indirect effects of several adverse working conditions on turnover intentions. The role of meaning of work as a psychological resource for employees facing adverse working conditions is discussed, especially regarding its implications for research and practice within organizational contexts.

Linking transformational leadership to nurses' extra-role performance: the mediating role of self-efficacy and work engagement.

Science.gov (United States)

Salanova, Marisa; Lorente, Laura; Chambel, Maria J; Martínez, Isabel M

2011-10-01

This paper is a report of a social cognitive theory-guided study about the link between supervisors' transformational leadership and staff nurses' extra-role performance as mediated by nurse self-efficacy and work engagement. Past research has acknowledged the positive influence that transformational leaders have on employee (extra-role) performance. However, less is known about the psychological mechanisms that may explain the links between transformational leaders and extra-role performance, which encompasses behaviours that are not considered formal job requirements, but which facilitate the smooth functioning of the organization as a social system. Seventeen supervisors evaluated nurses' extra-role performance, the data generating a sample consisting of 280 dyads. The nurses worked in different health services in a large Portuguese hospital and the participation rate was 76·9% for nurses and 100% for supervisors. Data were collected during 2009. A theory-driven model of the relationships between transformation leadership, self-efficacy, work engagement and nurses' extra-role performance was tested using Structural Equation Modelling. Data analysis revealed a full mediation model in which transformational leadership explained extra-role performance through self-efficacy and work engagement. A direct relationship between transformational leadership and work engagement was also found. Nurses' supervisors with a transformational leadership style enhance different 'extra-role' performance in nurses and this increases hospital efficacy. They do so by establishing a sense of self-efficacy but also by amplifying their levels of engagement in the workplace. © 2011 Blackwell Publishing Ltd.

Intrinsic motivation and sportsmanship: mediating role of interpersonal relationships.

Science.gov (United States)

Núñez, Juan L; Martín-Albo, José; Navarro, José G; Sánchez, Juana M; González-Cutre, David

2009-06-01

This study analyzed the mediating role of interpersonal relations between intrinsic motivation and sportsmanship. Athletes (98 men, 97 women), ages 11 to 43 years, completed measures of intrinsic motivation toward sports, self-concept of social and family relations, and sportsmanship orientation. A structural equation model indicated that self-concept of interpersonal relations mediated the relation between intrinsic motivation and sportsmanship. Also, intrinsic motivation was directly and positively associated with self-concept of interpersonal relations, which, in turn, was positively and significantly related to sportsmanship. Variances explained by self-concept of interpersonal relations and by sportsmanship were 32 and 56%, respectively. The motivational interaction between the context of interpersonal relations and the sports context proposed in the hierarchical model of intrinsic and extrinsic motivation was discussed.

The Ventriloquist's Dummy? The Role of Technology in Political Processes

DEFF Research Database (Denmark)

Koch, Christian

2000-01-01

technology and hire versa. In some phases, actors master the technology to the same extent as a ventriloquist masters his dummy. In other phases, however, actors Jinn themselves working hard, 'negotiating' with the technology. The management of technology is characterized as a consequence of these multiple......This article examines the active role of technology in political processes, drawing on organisational politics and sociology of technology. A case study of the processes of the management of technology demonstrates the multiple roles that technology plays in developing a promoting coalition...

Balancing participation and risks in children's Internet use: the role of internet literacy and parental mediation.

Science.gov (United States)

Lee, Sook-Jung; Chae, Young-Gil

2012-05-01

This study analyzed the survey data from 566 Korean children between the ages of 10 and 15 to examine the role of Internet literacy and parental mediation in solving the dilemma of children's Internet use. According to the findings, children's online participation was associated with increased exposure to online risks. The association was moderated by Internet skills and parental restrictive mediation; that is, for children with a high level of Internet skills and for children who received more restrictive mediation, the positive association between online participation and online risks weakened, but was still significant. The limited roles of Internet skills and parental restrictive mediation in children's Internet use were discussed in the context of media education.

Beyond knowledge and skills: the use of a Delphi study to develop a technology-mediated teaching strategy.

Science.gov (United States)

Rowe, Michael; Frantz, Jose; Bozalek, Vivienne

2013-04-10

While there is evidence to suggest that teaching practices in clinical education should include activities that more accurately reflect the real world, many educators base their teaching on transmission models that encourage the rote learning of knowledge and technical skills. Technology-mediated instruction may facilitate the development of professional attributes that go beyond "having" knowledge and skills, but there is limited evidence for how to integrate technology into these innovative teaching approaches. This study used a modified Delphi method to help identify the professional attributes of capable practitioners, the approaches to teaching that may facilitate the development of these attributes, and finally, how technology could be integrated with those teaching strategies in order to develop capable practitioners. Open-ended questions were used to gather data from three different expert panels, and results were thematically analysed. Clinical educators should not view knowledge, skills and attitudes as a set of products of learning, but rather as a set of attributes that are developed during a learning process. Participants highlighted the importance of continuing personal and professional development that emphasised the role of values and emotional response to the clinical context. To develop these attributes, clinical educators should use teaching activities that are learner-centred, interactive, integrated, reflective and that promote engagement. When technology-mediated teaching activities are considered, they should promote the discussion of clinical encounters, facilitate the sharing of resources and experiences, encourage reflection on the learning process and be used to access content outside the classroom. In addition, educational outcomes must drive the integration of technology into teaching practice, rather than the features of the technology. There is a need for a cultural change in clinical education, in which those involved with the

The Mediating Role of Psychosocial Benefits in the Satisfaction Formation Process

NARCIS (Netherlands)

O. Prevo; P. Leunisse; H. Roest (Henk)

1999-01-01

textabstractIn this paper we investigate the mediating role of psychosocial benefits in the customer satisfaction/dissatisfaction formation process. Most research on this subject deals with the causality direction of psychosocial benefits and satisfaction, sometimes preceded by an overall functional

The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease

Directory of Open Access Journals (Sweden)

Gholamreza Azizi

2015-08-01

Full Text Available Alzheimer’s disease (AD, a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofibrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Thus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. This review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the field of AD and similar diseases.

Exploring How Technology Mediates the Types of Relationships Formed in Sociotechnical Systems

Science.gov (United States)

Chu, Kar-Hai

2012-01-01

This work presents an exploratory study of how technology mediates the different types of relationships that are formed in sociotechnical systems. More people each day are connecting with each other through social networks, online communities, and other forms of virtual environments. Whether for education, information seeking, friendship,…

Industry growth, work role characteristics, and job satisfaction: a cross-level mediation model.

Science.gov (United States)

Ford, Michael T; Wooldridge, Jessica D

2012-10-01

The associations between industry revenue growth, individual work role characteristics, and job satisfaction were examined in this cross-level mediation analysis. Work roles were expected to be more autonomous, involve greater skill variety, and offer more opportunities for growth and development for workers in growing industries than for workers in declining industries. Supervisor support was also hypothesized to be stronger for workers in high-growth industries. Results from a nationally representative (U.S.) sample of service industry workers, using multilevel modeling, supported these propositions and suggest that job enrichment mediates relations between industry growth and job satisfaction. Associations between industry growth and autonomy were also stronger among workers in occupations that are less normatively autonomous, suggesting that industry growth fosters a weakening, and industry decline a strengthening, of traditional differences in autonomy across work roles. These results contribute to a multilevel perspective on organizational environments, individual work roles, and worker attitudes and well-being.

Authentic leadership and organizational commitment: the mediating role of positive psychological capital

International Nuclear Information System (INIS)

Rego, P.; Pereira Lopes, M.; Nascimento, J.

2016-01-01

Purpose: This study analyzes the mediating role of positive psychological capital in the relationship between authentic leadership and organizational commitment. Design/methodology/approach: This quantitative study presents a model in which were considered as variables mediating the relationship between authentic leadership and organizational commitment, the four dimensions of positive psychological capital (optimism, resilience, self-efficacy, hope). Findings: The results showed that positive psychological capital mediates the relationship between authentic leadership and organizational commitment. However, they also indicate that this mediation is only made for three of the four dimensions of positive psychological capital (self-efficacy, hope and optimism). They also show that resilience negatively affects organizational commitment. Originality/value: The value of this study is to strengthen the interest in the study of positive psychological capital as a mediating variable and the importance of development that each of its dimensions and the impact they may have on other variables, as demonstrated by the results. (Author)

Authentic leadership and organizational commitment: the mediating role of positive psychological capital

Energy Technology Data Exchange (ETDEWEB)

Rego, P.; Pereira Lopes, M.; Nascimento, J.

2016-07-01

Purpose: This study analyzes the mediating role of positive psychological capital in the relationship between authentic leadership and organizational commitment. Design/methodology/approach: This quantitative study presents a model in which were considered as variables mediating the relationship between authentic leadership and organizational commitment, the four dimensions of positive psychological capital (optimism, resilience, self-efficacy, hope). Findings: The results showed that positive psychological capital mediates the relationship between authentic leadership and organizational commitment. However, they also indicate that this mediation is only made for three of the four dimensions of positive psychological capital (self-efficacy, hope and optimism). They also show that resilience negatively affects organizational commitment. Originality/value: The value of this study is to strengthen the interest in the study of positive psychological capital as a mediating variable and the importance of development that each of its dimensions and the impact they may have on other variables, as demonstrated by the results. (Author)

Authentic leadership and organizational commitment: The mediating role of positive psychological capital

Directory of Open Access Journals (Sweden)

Paulo Rego

2016-02-01

Full Text Available Purpose: This study analyzes the mediating role of positive psychological capital in the relationship between authentic leadership and organizational commitment. Design/methodology/approach: This quantitative study presents a model in which were considered as variables mediating the relationship between authentic leadership and organizational commitment, the four dimensions of positive psychological capital (optimism, resilience, self-efficacy, hope. Findings: The results showed that positive psychological capital mediates the relationship between authentic leadership and organizational commitment. However, they also indicate that this mediation is only made for three of the four dimensions of positive psychological capital (self-efficacy, hope and optimism. They also show that resilience negatively affects organizational commitment. Originality/value: The value of this study is to strengthen the interest in the study of positive psychological capital as a mediating variable and the importance of development that each of its dimensions and the impact they may have on other variables, as demonstrated by the results.

Salmonella-mediated cancer therapy: Roles and potential

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Vu Hong [Dept. of Experimental TherapeuticsBeckman Research Institute of City of Hope, Duarte (United States); Min, Jung Joon [Dept. of Nuclear MedicineChonnam National University Medical School, Gwangju (Korea, Republic of)

2017-06-15

The use of bacteria for cancer therapy, which was proposed many years ago, was not recognized as a potential therapeutic strategy until recently. Technological advances and updated knowledge have enabled the genetic engineering of bacteria for their safe and effective application in the treatment of cancer. The efficacy of radiotherapy depends mainly on tissue oxygen levels, and low oxygen concentrations in necrotic and hypoxic regions are a common cause of treatment failure. In addition, the distribution of a drug is important for the therapeutic effect of chemotherapy, and the poor vasculature in tumors impairs drug delivery, limiting the efficacy of a drug, especially in necrotic and hypoxic regions. Bacteria-mediated cancer therapy (BMCT) relies on facultative anaerobes that can survive in well or poorly oxygenated regions, and it therefore improves the therapeutic efficacy drug distribution throughout the tumor mass. Since the mid-1990s, the number of published bacterial therapy papers has increased rapidly, with a doubling time of 2.5 years in which the use of Salmonella increased significantly. BMCT is being reevaluated to overcome some of the drawbacks of conventional therapies. This review focuses on Salmonella-mediated cancer therapy as the most widely used type of BMCT.{sub 2}.

Salmonella-mediated cancer therapy: Roles and potential

International Nuclear Information System (INIS)

Nguyen, Vu Hong; Min, Jung Joon

2017-01-01

The use of bacteria for cancer therapy, which was proposed many years ago, was not recognized as a potential therapeutic strategy until recently. Technological advances and updated knowledge have enabled the genetic engineering of bacteria for their safe and effective application in the treatment of cancer. The efficacy of radiotherapy depends mainly on tissue oxygen levels, and low oxygen concentrations in necrotic and hypoxic regions are a common cause of treatment failure. In addition, the distribution of a drug is important for the therapeutic effect of chemotherapy, and the poor vasculature in tumors impairs drug delivery, limiting the efficacy of a drug, especially in necrotic and hypoxic regions. Bacteria-mediated cancer therapy (BMCT) relies on facultative anaerobes that can survive in well or poorly oxygenated regions, and it therefore improves the therapeutic efficacy drug distribution throughout the tumor mass. Since the mid-1990s, the number of published bacterial therapy papers has increased rapidly, with a doubling time of 2.5 years in which the use of Salmonella increased significantly. BMCT is being reevaluated to overcome some of the drawbacks of conventional therapies. This review focuses on Salmonella-mediated cancer therapy as the most widely used type of BMCT._2

Transformational leadership and project success : The mediating role of team-building

NARCIS (Netherlands)

Aga, Deribe Assefa; Noorderhaven, Niels; Vallejo, Bertha

2016-01-01

Although the effect of transformational leadership on project success is empirically supported, less is known about the mechanisms that explain this effect. To address this issue, we propose the mediating role of team-building as a possible explanation of the relationship between transformational

Core self-evaluation and burnout among Nurses: the mediating role of coping styles.

Directory of Open Access Journals (Sweden)

Xiaofei Li

Full Text Available OBJECTIVES: This study aimed to determine the potential association between core self-evaluation and the burnout syndrome among Chinese nurses, and the mediating role of coping styles in this relationship. METHODS: A cross-sectional survey was conducted in Shenyang, China, from May to July, 2013. A questionnaire which consisted of the Maslach Burnout Inventory-General Survey (MBI-GS, the Core Self-Evaluation Scale (CSE, and the Simplified Coping Style Questionnaire (CSQ, was completed by a total of 1,559 nurses. Hierarchical linear regression analyses and the Sobel test were performed to determine the mediating role of coping styles on the relationship between CSE and burnout. RESULTS: Nurses who had higher self-evaluation characteristics, reported less emotional exhaustion and cynicism, and higher professional efficacy. Coping style had a partial mediating effect on the relationship between CSE and the burnout syndrome among nurses. CONCLUSIONS: Core self-evaluation had effects on burnout and coping style was a mediating factor in this relationship among Chinese nurses. Therefore, the improvement of coping strategies may be helpful in the prevention of burnout among nurses, thus enhancing professional performance.

Core Self-Evaluation and Burnout among Nurses: The Mediating Role of Coping Styles

Science.gov (United States)

Li, Xiaofei; Guan, Lili; Chang, Hui; Zhang, Bo

2014-01-01

Objectives This study aimed to determine the potential association between core self-evaluation and the burnout syndrome among Chinese nurses, and the mediating role of coping styles in this relationship. Methods A cross-sectional survey was conducted in Shenyang, China, from May to July, 2013. A questionnaire which consisted of the Maslach Burnout Inventory-General Survey (MBI-GS), the Core Self-Evaluation Scale (CSE), and the Simplified Coping Style Questionnaire (CSQ), was completed by a total of 1,559 nurses. Hierarchical linear regression analyses and the Sobel test were performed to determine the mediating role of coping styles on the relationship between CSE and burnout. Results Nurses who had higher self-evaluation characteristics, reported less emotional exhaustion and cynicism, and higher professional efficacy. Coping style had a partial mediating effect on the relationship between CSE and the burnout syndrome among nurses. Conclusions Core self-evaluation had effects on burnout and coping style was a mediating factor in this relationship among Chinese nurses. Therefore, the improvement of coping strategies may be helpful in the prevention of burnout among nurses, thus enhancing professional performance. PMID:25541990

Mediating Role of Career Commitment in the Relationship of Promotional Opportunities, Rewards and Career Success

Directory of Open Access Journals (Sweden)

Ahmad Tisman Pasha

2017-03-01

Full Text Available The objective of the study is to investigate the mediating role of career commitment between career development practices and career success of employee in insurance sector of Pakistan. Survey method was adopted to collect the data form 374 employees working in insurance sector systematic sampling. PLS-SEM technique was used using Smart PLS 2.0 to analyze the data. Findings of the study suggests that employees’ career development practices have positive relationship with career commitment and career success. Career commitment also have a positive relation with career success. Finally, career commitment mediates the positive role between career development practices and career of insurance sector employees. The effect of career development practices on career commitment and effect of career development practices on career success has been checked in past studies but the mediating role of career commitment particularly for the employees of insurance sector has not been checked before.

The mediating role of parental expectations in culture and well-being.

Science.gov (United States)

Oishi, Shigehiro; Sullivan, Helen W

2005-10-01

In two studies, we examined the role of perceived fulfillment of parental expectations in the subjective well-being of college students. In Study 1, we found that American college students reported having higher levels of life satisfaction and self-esteem than did Japanese college students. American college students also reported having fulfilled parental expectations to a greater degree than did Japanese college students. Most importantly, the cultural difference in well-being was mediated by perceived fulfillment of parental expectations. In Study 2, we replicated the mediational finding with Asian American and European American college students. Asian American participants also perceived their parents' expectations about their academic performance to be more specific than did European Americans, which was associated with the cultural difference in perceived fulfillment of parental expectations. In short, perceived parental expectations play an important role in the cultural difference in the well-being of Asians and European Americans.

Addressing Climate Change and the Role of Technological Solutions

Directory of Open Access Journals (Sweden)

Stephen Axon

2010-05-01

Full Text Available As far as sustainability is concerned, the role of technology has always been contested. With regard to environmental degradation, technology is either perceived to be part of the problem or part of the solution. To combat the complex issues of the present time, technological solutions are expected to play a key role towards mitigating and adapting to the negative impacts of climate change. The paper also discusses the role of the 2009 Copenhagen Conference towards addressing climate change. Although the Copenhagen Accord is not a legally binding agreement, it is seen as a necessary first step towards a protocol that will effectively address the issue of climate change.

Big five personality and adolescent Internet addiction: The mediating role of coping style.

Science.gov (United States)

Zhou, Yueyue; Li, Dongping; Li, Xian; Wang, Yanhui; Zhao, Liyan

2017-01-01

This study examined the unique associations between big five personality traits and adolescent Internet addiction (IA), as well as the mediating role of coping style underlying these relations. Our theoretical model was tested with 998 adolescents. Participants provided self-report data on demographic variables, big five personality traits, coping style, and IA. After controlling for demographic variables, it was found that agreeableness and conscientiousness were negatively associated with IA, whereas extraversion, neuroticism, and openness to experience were positively associated with IA. Mediation analyses further indicated that conscientiousness had an indirect impact on adolescent IA through decreased emotion-focused coping, whereas extraversion, neuroticism, openness to experience had indirect impacts on adolescent IA through increased emotion-focused coping. In contrast, problem-focused coping had no mediating role. These findings suggest that emotion-focused coping may, in part, account for the association between big five personality and adolescent IA. Copyright © 2016 Elsevier Ltd. All rights reserved.

Integrating Technology: The Principals' Role and Effect

Science.gov (United States)

Machado, Lucas J.; Chung, Chia-Jung

2015-01-01

There are many factors that influence technology integration in the classroom such as teacher willingness, availability of hardware, and professional development of staff. Taking into account these elements, this paper describes research on technology integration with a focus on principals' attitudes. The role of the principal in classroom…

The mediating role of self-efficacy in the development of entrepreneurial intentions.

Science.gov (United States)

Zhao, Hao; Seibert, Scott E; Hills, Gerald E

2005-11-01

The purpose of this study was to investigate the mediating role of self-efficacy in the development of students' intentions to become entrepreneurs. The authors used structural equation modeling with a sample of 265 master of business administration students across 5 universities to test their hypotheses. The results showed that the effects of perceived learning from entrepreneurship-related courses, previous entrepreneurial experience, and risk propensity on entrepreneurial intentions were fully mediated by entrepreneurial self-efficacy. Contrary to expectations, gender was not mediated by self-efficacy but had a direct effect such that women reported lower entrepreneurial career intentions. The authors discuss practical implications and directions for future research. ((c) 2005 APA, all rights reserved).

The role of mediation institutions in Sweden and Denmark after centralized bargaining

DEFF Research Database (Denmark)

Ibsen, Christian Lyhne

2016-01-01

not explain the internal stability of bargaining coordination once established. This analysis stresses the role of mediation institutions of both countries for solving collective action problems in pattern bargaining by pegging other settlements to the manufacturing labour cost norm. Mediation capabilities......This article compares coordinated collective bargaining in Sweden and Denmark after centralized bargaining. Existing theories — power resource and cross-class alliance theory — seem capable of explaining the transition from centralized bargaining to pattern bargaining system. However, they do...

A role for host cell exocytosis in InlB-mediated internalisation of Listeria monocytogenes.

Science.gov (United States)

Van Ngo, Hoan; Bhalla, Manmeet; Chen, Da-Yuan; Ireton, Keith

2017-11-01

The bacterial surface protein InlB mediates internalisation of Listeria monocytogenes into human cells through interaction with the host receptor tyrosine kinase, Met. InlB-mediated entry requires localised polymerisation of the host actin cytoskeleton. Apart from actin polymerisation, roles for other host processes in Listeria entry are unknown. Here, we demonstrate that exocytosis in the human cell promotes InlB-dependent internalisation. Using a probe consisting of VAMP3 with an exofacial green fluorescent protein tag, focal exocytosis was detected during InlB-mediated entry. Exocytosis was dependent on Met tyrosine kinase activity and the GTPase RalA. Depletion of SNARE proteins by small interfering RNA demonstrated an important role for exocytosis in Listeria internalisation. Depletion of SNARE proteins failed to affect actin filaments during internalisation, suggesting that actin polymerisation and exocytosis are separable host responses. SNARE proteins were required for delivery of the human GTPase Dynamin 2, which promotes InlB-mediated entry. Our results identify exocytosis as a novel host process exploited by Listeria for infection. © 2017 John Wiley & Sons Ltd.

Sociopolitical analysis of the role of mediating of international organizations in conflicts at Burundi and Uganda

Directory of Open Access Journals (Sweden)

Alexandre Cesar Cunha Leite

2016-06-01

Full Text Available This article aims to discuss the effectiveness of the mediator role of the United Nations and the African Union on conflict resolution in the cases of Burundi and Uganda. The argument is that this mediating role influenced considerably in the negotiations since it realized a ceasefire in hostilities between the warring parties and the establishment of more significant agreements on pending issues. For this discussion, we attempted to describe the processes of successful mediation in recent decades in Africa, based on the cases as mentioned above, whose similar methods of resolution could achieve positive results. Finally, we evaluated the effectiveness of UN mediator in the field of maintenance and promotion of peace, emphasizing their strategies on reducing violence on the ground and in the protection of civilians.

Work Engagement: Antecedents, the Mediating Role of Learning Goal Orientation and Job Performance

Science.gov (United States)

Chughtai, Aamir Ali; Buckley, Finian

2011-01-01

Purpose: The present paper aims to explore the effects of state (trust in supervisor) and trait (trust propensity) trust on employees' work engagement. Furthermore, it seeks to investigate the mediating role of learning goal orientation in the relationship between work engagement and two forms of performance: in-role job performance and innovative…

Peer Victimization and Dating Violence Victimization: The Mediating Role of Loneliness, Depressed Mood, and Life Satisfaction.

Science.gov (United States)

Cava, María-Jesús; Buelga, Sofía; Tomás, Inés

2018-03-01

Peer victimization and dating violence victimization have serious negative effects on adolescents' health, and they seem to be related. However, the mediating processes in this relationship have not been sufficiently analyzed. The purpose of this study was to analyze the direct and indirect relationships between peer victimization and dating violence victimization, considering the possible mediator role of loneliness, depressed mood, and life satisfaction. These relationships are analyzed in boys and girls, and in early and middle adolescence. From an initial sample of 1,038 Spanish adolescents, those who had or had had in the past 12 months a dating relationship (647 adolescents; 49.1% boys, M = 14.38, SD = 1.43) were included in this study. Multigroup structural equation modeling was used to test a double mediation model simultaneously for boys and girls, testing the invariance of the relationships among variables across genders. The same technique was used to test the model simultaneously for early and middle adolescence, testing the invariance of the relationships among variables across age groups. Results revealed a positive direct relationship between peer victimization and dating violence victimization, as well as the partial mediating role of loneliness and life satisfaction in this relationship. The mediator role of depressed mood was not supported. The same mediational model was confirmed in boys and girls, and in early and middle adolescence. These results highlight the important role of loneliness and life satisfaction to explain the link between peer victimization and dating violence victimization in adolescence. These findings may be useful for developing intervention programs aimed at preventing situations of multiple victimization during adolescence.

The mediating role of disgust sensitivity and thought-action fusion between religiosity and obsessive compulsive symptoms.

Science.gov (United States)

Inozu, Mujgan; Ulukut, Fulya Ozcanli; Ergun, Gokce; Alcolado, Gillian M

2014-10-01

Psychological theories of obsessions and compulsions have long recognised that strict religious codes and moral standards might promote thought-action fusion (TAF) appraisals. These appraisals have been implicated in the transformation of normally occurring intrusions into clinically distressing obsessions. Furthermore, increased disgust sensitivity has also been reported to be associated with obsessive compulsive (OC) symptoms. No research, however, has investigated the mediating roles of TAF and disgust sensitivity between religiosity and OC symptoms. This study was composed of 244 undergraduate students who completed measures of OC symptoms, TAF, disgust sensitivity, religiosity and negative effect. Analyses revealed that the relationship between religiosity and OC symptoms was mediated by TAF and disgust sensitivity. More importantly, the mediating role of TAF was not different across OC symptom subtypes, whereas the mediating role of disgust sensitivity showed different patterns across OC symptom subtypes. These findings indicate that the tendency for highly religious Muslims to experience greater OC symptoms is related to their heightened beliefs about disgust sensitivity and the importance of thoughts. © 2014 International Union of Psychological Science.

Job insecurity and job performance: The moderating role of organizational justice and the mediating role of work engagement.

Science.gov (United States)

Wang, Hai-jiang; Lu, Chang-qin; Siu, Oi-ling

2015-07-01

Organizational justice has been shown to play an important role in employees' affective and performance outcomes particularly in uncertain contexts. In this study, we investigated the interaction effect of job insecurity and organizational justice on employees' performance, and examined the mediating role of work engagement from the perspective of uncertainty management theory. We used 2-wave data (Study 1) from a sample of 140 Chinese employees and 3-wave data (Study 2) from a sample of 125 Chinese employees to test our hypotheses. In Study 1, we found that when employees perceived low levels of organizational justice, job insecurity was significantly negatively related to job performance. In contrast, we found that job insecurity was not related to job performance when there were high levels of organizational justice. Study 2 again supported the interaction of job insecurity and organizational justice on job performance. Furthermore, it was found that work engagement mediated the interaction effect. The results of the mediated moderation analysis revealed that job insecurity was negatively associated with job performance through work engagement when organizational justice was low. (c) 2015 APA, all rights reserved).

Examining the stress-burnout relationship: the mediating role of negative thoughts.

Science.gov (United States)

Chang, Ko-Hsin; Lu, Frank J H; Chyi, Theresa; Hsu, Ya-Wen; Chan, Shi-Wei; Wang, Erica T W

2017-01-01

Using Smith's (1986) cognitive-affective model of athletic burnout as a guiding framework, the purpose of this study was to examine the relationships among athletes' stress in life, negative thoughts, and the mediating role of negative thoughts on the stress-burnout relationship. A total of 300 college student-athletes (males = 174; females = 126, M age  = 20.43 y, SD = 1.68) completed the College Student Athlete's Life Stress Scale (CSALSS; Lu et al., 2012), the Automatic Thoughts Questionnaire (ATQ; Hollon & Kendall, 1980), and the Athlete Burnout Questionnaire (ABQ; Raedeke & Smith, 2001). Correlational analyses found that two types of life stress and four types of negative thoughts correlated with burnout. Additionally, hierarchical regression analyses found that four types of negative thoughts partially mediated the stress-burnout relationship. We concluded that an athlete's negative thoughts play a pivotal role in predicting athletes' stress-burnout relationship. Future study may examine how irrational cognition influences athletes' motivation and psychological well-being.

Examining the stress-burnout relationship: the mediating role of negative thoughts

Science.gov (United States)

Chyi, Theresa; Hsu, Ya-Wen; Chan, Shi-Wei; Wang, Erica T.W.

2017-01-01

Background Using Smith’s (1986) cognitive-affective model of athletic burnout as a guiding framework, the purpose of this study was to examine the relationships among athletes’ stress in life, negative thoughts, and the mediating role of negative thoughts on the stress-burnout relationship. Methods A total of 300 college student-athletes (males = 174; females = 126, Mage = 20.43 y, SD = 1.68) completed the College Student Athlete’s Life Stress Scale (CSALSS; Lu et al., 2012), the Automatic Thoughts Questionnaire (ATQ; Hollon & Kendall, 1980), and the Athlete Burnout Questionnaire (ABQ; Raedeke & Smith, 2001). Results Correlational analyses found that two types of life stress and four types of negative thoughts correlated with burnout. Additionally, hierarchical regression analyses found that four types of negative thoughts partially mediated the stress-burnout relationship. Discussion We concluded that an athlete’s negative thoughts play a pivotal role in predicting athletes’ stress-burnout relationship. Future study may examine how irrational cognition influences athletes’ motivation and psychological well-being. PMID:29302397

Drivers of Employee Motivation: Mediating Role of Job Satisfaction

OpenAIRE

Azeem, Sabeen

2016-01-01

Employee Motivation is a growing area of importance for the Human Resource Departments organizations of all sizes. Managing the workforce efficiently and effectively has become crucial in order to achieve excellent output from the employees which would lead to the attainment of organizational goals. This study aims to understand the influence of multiple motivational factors on employee motivation of employees of Bank A. Additionally, the mediating role of job satisfaction is elaborated which...

Transformational Leadership and Knowledge Sharing: Mediating Roles of Employee's Empowerment, Commitment, and Citizenship Behaviors

Science.gov (United States)

Han, Seung Hyun; Seo, Gaeun; Yoon, Seung Won; Yoon, Dong-Yeol

2016-01-01

Purpose: The purpose of this paper is to empirically examine the fundamental process through which transformational leaders play a significant role in employees' knowledge sharing by investigating mediating roles of individual affects, particularly psychological empowerment, organizational commitment and organizational citizenship behavior (OCB).…

Leader-member exchange and safety citizenship behavior: The mediating role of coworker trust.

Science.gov (United States)

Jiang, Li; Li, Feng; Li, YongJuan; Li, Rui

2017-01-01

To achieve high safety levels, mere compliance with safety regulations is not sufficient; employees must be proactive and demonstrate safety citizenship behaviors. Trust is considered as a mechanism for facilitating the effects of a leader on employee citizenship behaviors. Increasingly research has focused on the role of trust in a safety context; however, the role of coworker trust has been overlooked. The mediating role of coworker trust in the relationship between the leader-member exchange and safety citizenship behavior is the focus of this field study. Front-line employees from an air traffic control center and an airline maintenance department completed surveys measuring leader-member exchange, co-worker trust, and safety citizenship behavior. Structural Equation Modeling revealed affective and cognitive trust in coworkers is influenced by leader-member exchange. A trust-based mediation model where cognitive trust and affective trust mediate the relationship between the leader-member exchange and safety citizenship behavior emerged. Results of this study add to our understanding of the relationship between leader-member exchange and safety behavior. The effect of co-worker trust and the extent to which employees participate in workplace safety practice were identified as critical factors. The findings show that managers need to focus on developing cognitive and affective coworker trust to improve safety citizenship behaviors.

The Relationship between Psychological Contract Breach and Organizational Commitment: Exchange Imbalance as a Moderator of the Mediating Role of Violation

Science.gov (United States)

Cassar, Vincent; Briner, Rob B.

2011-01-01

This study tested the mediating role of violation in the relationship between breach and both affective and continuance commitment and the extent to which this mediating role is moderated by exchange imbalance amongst a sample of 103 sales personnel. Results suggest that violation mediated the relationship between breach and commitment. Also,…

Role stressors and job attitudes: a mediated model of leader-member exchange.

Science.gov (United States)

Zhang, Rui-Ping; Tsingan, Li; Zhang, Long-Ping

2013-01-01

Workers with high levels of role stressors have been known to report low job satisfaction and high turnover intention. However, how the role stressors-job attitudes relationship is influenced by leader-member exchange has hardly been studied. This study examined the effect of leader-member exchange (leader support) on the relationship between chronic role stressors (i.e., role ambiguity and role conflict) and job attitudes (i.e., job satisfaction and turnover intention). Employees (N = 162) who enrolled in weekend psychology courses were investigated. The results showed that leader-member exchange mediated the effects of role stressors on job satisfaction and turnover intention. Implications of these results are discussed and directions for future research are suggested.

Role of CD137 signaling in dengue virus-mediated apoptosis

International Nuclear Information System (INIS)

Nagila, Amar; Netsawang, Janjuree; Srisawat, Chatchawan; Noisakran, Sansanee; Morchang, Atthapan; Yasamut, Umpa; Puttikhunt, Chunya; Kasinrerk, Watchara

2011-01-01

Highlights: → For the first time the role of CD137 in dengue virus (DENV) infection. → Induction of DENV-mediated apoptosis by CD137 signaling. → Sensitization to CD137-mediated apoptosis by dengue virus capsid protein (DENV C). → Nuclear localization of DENV C is required for CD137-mediated apoptosis. -- Abstract: Hepatic dysfunction is a well recognized feature of dengue virus (DENV) infection. However, molecular mechanisms of hepatic injury are still poorly understood. A complex interaction between DENV and the host immune response contributes to DENV-mediated tissue injury. DENV capsid protein (DENV C) physically interacts with the human death domain-associated protein Daxx. A double substitution mutation in DENV C (R85A/K86A) abrogates Daxx interaction, nuclear localization and apoptosis. Therefore we compared the expression of cell death genes between HepG2 cells expressing DENV C and DENV C (R85A/K86A) using a real-time PCR array. Expression of CD137, which is a member of the tumor necrosis factor receptor family, increased significantly in HepG2 cells expressing DENV C compared to HepG2 cells expressing DENV C (R85A/K86A). In addition, CD137-mediated apoptotic activity in HepG2 cells expressing DENV C was significantly increased by anti-CD137 antibody compared to that of HepG2 cells expressing DENV C (R85A/K86A). In DENV-infected HepG2 cells, CD137 mRNA and CD137 positive cells significantly increased and CD137-mediated apoptotic activity was increased by anti-CD137 antibody. This work is the first to demonstrate the contribution of CD137 signaling to DENV-mediated apoptosis.

Role of CD137 signaling in dengue virus-mediated apoptosis

Energy Technology Data Exchange (ETDEWEB)

Nagila, Amar [Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok (Thailand); Department of Biochemistry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok (Thailand); Netsawang, Janjuree [Faculty of Medical Technology, Rangsit University, Bangkok (Thailand); Srisawat, Chatchawan [Department of Biochemistry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok (Thailand); Noisakran, Sansanee [Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok (Thailand); Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok (Thailand); Morchang, Atthapan; Yasamut, Umpa [Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok (Thailand); Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok (Thailand); Puttikhunt, Chunya [Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok (Thailand); Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok (Thailand); Kasinrerk, Watchara [Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai (Thailand); Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency at Chiang Mai University, Chiang Mai (Thailand); and others

2011-07-08

Highlights: {yields} For the first time the role of CD137 in dengue virus (DENV) infection. {yields} Induction of DENV-mediated apoptosis by CD137 signaling. {yields} Sensitization to CD137-mediated apoptosis by dengue virus capsid protein (DENV C). {yields} Nuclear localization of DENV C is required for CD137-mediated apoptosis. -- Abstract: Hepatic dysfunction is a well recognized feature of dengue virus (DENV) infection. However, molecular mechanisms of hepatic injury are still poorly understood. A complex interaction between DENV and the host immune response contributes to DENV-mediated tissue injury. DENV capsid protein (DENV C) physically interacts with the human death domain-associated protein Daxx. A double substitution mutation in DENV C (R85A/K86A) abrogates Daxx interaction, nuclear localization and apoptosis. Therefore we compared the expression of cell death genes between HepG2 cells expressing DENV C and DENV C (R85A/K86A) using a real-time PCR array. Expression of CD137, which is a member of the tumor necrosis factor receptor family, increased significantly in HepG2 cells expressing DENV C compared to HepG2 cells expressing DENV C (R85A/K86A). In addition, CD137-mediated apoptotic activity in HepG2 cells expressing DENV C was significantly increased by anti-CD137 antibody compared to that of HepG2 cells expressing DENV C (R85A/K86A). In DENV-infected HepG2 cells, CD137 mRNA and CD137 positive cells significantly increased and CD137-mediated apoptotic activity was increased by anti-CD137 antibody. This work is the first to demonstrate the contribution of CD137 signaling to DENV-mediated apoptosis.

Participation in organized sport and self-esteem across adolescence: the mediating role of perceived sport competence.

Science.gov (United States)

Wagnsson, Stefan; Lindwall, Magnus; Gustafsson, Henrik

2014-12-01

The purpose of the study was to test longitudinal (2 years across three occasions) associations between sport participation (SP) and self-esteem (SE) across adolescence (10-18 years), addressing the mediating role of perceived sport competence (PSC) from a developmental perspective. Three waves of data were collected from three age cohorts (10-12, 13-15, and 16-18 years) of school-aged youth (N = 1358). The results demonstrate that SP and SE are related across time and that PSC has an important mediating role in this relationship, both from a skill development and a self-enhancement perspective. In the skill development model, the mediating role of PSC was significantly stronger in the youngest cohort whereas the effect of PSC on subsequent SP in the self-enhancement model was significantly stronger in the 13-15 age group compared with the youngest age group.

The mediating role of guanxi network and communication performance in transforming Web 2.0 technologies usage to work performance : An empirical study in China

NARCIS (Netherlands)

Wong, L.H.M.; Davison, R.M.; Ou, C.X.J.; Cheng, Z.; Tan, F.B.; Bunker, D.

2014-01-01

Motivated by both the increasing popularity of Web 2.0 technologies and the lack of empirical studies to conceptualize and validate their roles in the work place, in this research we aim to establish a research model to capture how Web 2.0 technologies can enhance individual work performance.

Role of bacterial virulence proteins in Agrobacterium-mediated transformation of Aspergillus awamori

NARCIS (Netherlands)

Michielse, C.B.; Ram, A.F.J.; Hooykaas, P.J.J.; Hondel, C.A.M.J.J. van den

2004-01-01

The Agrobacterium-mediated transformation of Aspergillus awamori was optimized using defined co-cultivation conditions, which resulted in a reproducible and efficient transformation system. Optimal co-cultivation conditions were used to study the role of Agrobacterium tumefaciens virulence proteins

Social capital and health in China: exploring the mediating role of lifestyle.

Science.gov (United States)

Xue, Xindong; Cheng, Mingmei

2017-11-06

Although social capital as a key determinant of health has been well established in various studies, little is known about how lifestyle factors mediate this relationship. Understanding the cross-relationships between social capital, health, and lifestyle factors is important if health promotion policies are to be effective. The purpose of this study is to explore whether different dimensions of social capital and lifestyle factors are related, and whether lifestyle factors mediate the association between social capital and self-rated health (SRH) and psychological well-being (PWB) in China. This study used nationally representative data from the 2014 China Family Panel Studies (n = 28,916). The data reported on three dimensions of individual-level social capital: social trust, social relationship and Chinese Communist Party (CCP) membership. Health was assessed using SRH and PWB. Five lifestyle indicators were recorded: healthy diet, physical activity, smoking, sleeping, and non-overweight status. Logistic regression was used to examine the associations between social capital and lifestyle factors, and whether there was a mediating role of lifestyle. Odds ratios relating health status to social capital were reported before and after adjustment for lifestyle factors. Mediation analysis was then used to calculate the total, direct and indirect effects of social capital on SRH and PWB. The results show that social trust was significantly associated with all five lifestyle factors. Social relationship was significantly associated with four of the five: healthy diet, physical activity, sleeping and non-overweight. CCP membership was only significantly associated with two lifestyle factors: physical activity and non-overweight. Social trust and social relationship were significantly related to both SRH and PWB. CCP membership was only significantly related to SRH. Mediation analysis found modest evidence that lifestyle factors influenced the relationship between all

Social capital and health in China: exploring the mediating role of lifestyle

Directory of Open Access Journals (Sweden)

Xindong Xue

2017-11-01

Full Text Available Abstract Background Although social capital as a key determinant of health has been well established in various studies, little is known about how lifestyle factors mediate this relationship. Understanding the cross-relationships between social capital, health, and lifestyle factors is important if health promotion policies are to be effective. The purpose of this study is to explore whether different dimensions of social capital and lifestyle factors are related, and whether lifestyle factors mediate the association between social capital and self-rated health (SRH and psychological well-being (PWB in China. Methods This study used nationally representative data from the 2014 China Family Panel Studies (n = 28,916. The data reported on three dimensions of individual-level social capital: social trust, social relationship and Chinese Communist Party (CCP membership. Health was assessed using SRH and PWB. Five lifestyle indicators were recorded: healthy diet, physical activity, smoking, sleeping, and non-overweight status. Logistic regression was used to examine the associations between social capital and lifestyle factors, and whether there was a mediating role of lifestyle. Odds ratios relating health status to social capital were reported before and after adjustment for lifestyle factors. Mediation analysis was then used to calculate the total, direct and indirect effects of social capital on SRH and PWB. Results The results show that social trust was significantly associated with all five lifestyle factors. Social relationship was significantly associated with four of the five: healthy diet, physical activity, sleeping and non-overweight. CCP membership was only significantly associated with two lifestyle factors: physical activity and non-overweight. Social trust and social relationship were significantly related to both SRH and PWB. CCP membership was only significantly related to SRH. Mediation analysis found modest evidence that

A novel theory: biological processes mostly involve two types of mediators, namely general and specific mediators Endogenous small radicals such as superoxide and nitric oxide may play a role of general mediator in biological processes.

Science.gov (United States)

Mo, Jian

2005-01-01

A great number of papers have shown that free radicals as well as bioactive molecules can play a role of mediator in a wide spectrum of biological processes, but the biological actions and chemical reactivity of the free radicals are quite different from that of the bioactive molecules, and that a wide variety of bioactive molecules can be easily modified by free radicals due to having functional groups sensitive to redox, and the significance of the interaction between the free radicals and the bioactive molecules in biological processes has been confirmed by the results of some in vitro and in vivo studies. Based on these evidence, this article presented a novel theory about the mediators of biological processes. The essentials of the theory are: (a) mediators of biological processes can be classified into general and specific mediators; the general mediators include two types of free radicals, namely superoxide and nitric oxide; the specific mediators include a wide variety of bioactive molecules, such as specific enzymes, transcription factors, cytokines and eicosanoids; (b) a general mediator can modify almost any class of the biomolecules, and thus play a role of mediator in nearly every biological process via diverse mechanisms; a specific mediator always acts selectively on certain classes of the biomolecules, and may play a role of mediator in different biological processes via a same mechanism; (c) biological processes are mostly controlled by networks of their mediators, so the free radicals can regulate the last consequence of a biological process by modifying some types of the bioactive molecules, or in cooperation with these bioactive molecules; the biological actions of superoxide and nitric oxide may be synergistic or antagonistic. According to this theory, keeping the integrity of these networks and the balance between the free radicals and the bioactive molecules as well as the balance between the free radicals and the free radical scavengers

Obstetric Ultrasound and the Technological Meditation of Morality.

NARCIS (Netherlands)

Verbeek, Peter P.C.C.

2008-01-01

This article analyzes the moral relevance of technological artifacts and its possible role in ethical theory, by taking the postphenomenological approach that has developed around the work of Don Ihde into the domain of ethics. By elaborating a postphenomenological analysis of the mediating role of

Why is discrimination stressful? The mediating role of cognitive appraisal.

Science.gov (United States)

King, Kimberly R

2005-08-01

This study attempts to shed light on past findings that experiences of racial and gender discrimination are associated with poor psychological and physical health outcomes by investigating the role of cognitive appraisal as a mediator of the relationship between experiences of discrimination and affective stress reactions. African American female college students (N = 115) imagined themselves in an audiotaped scenario in which they overheard 2 European American male classmates make negative evaluations of them. Participants then completed measures of causal attributions, cognitive appraisal, and affective stress reactions. Multiple regression analyses supported the hypotheses that attributions to racism and to discrimination that combines racism and sexism were associated with increased stress reactions. This relationship was mediated by cognitive appraisals of centrality. (c) 2005 APA

Designing a good life: a matrix for the technological mediation of morality.

Science.gov (United States)

Swierstra, Tsjalling; Waelbers, Katinka

2012-03-01

Technologies fulfill a social role in the sense that they influence the moral actions of people, often in unintended and unforeseen ways. Scientists and engineers are already accepting much responsibility for the technological, economical and environmental aspects of their work. This article asks them to take an extra step, and now also consider the social role of their products. The aim is to enable engineers to take a prospective responsibility for the future social roles of their technologies by providing them with a matrix that helps to explore in advance how emerging technologies might plausibly affect the reasons behind people's (moral) actions. On the horizontal axis of the matrix, we distinguished the three basic types of reasons that play a role in practical judgment: what is the case, what can be done and what should be done. On the vertical axis we distinguished the morally relevant classes of issues: stakeholders, consequences and the good life. To illustrate how this matrix may work in practice, the final section applies the matrix to the case of the Google PowerMeter. © The Author(s) 2010. This article is published with open access at Springerlink.com

URBAN CHILDHOOD ROUTINES MEDIATED BY TECHNOLOGY: A VISUAL ANALYSIS

Directory of Open Access Journals (Sweden)

González-Patiño, Javier

2011-07-01

Full Text Available With the goal of documenting routines in which a technological component had some type of impact and observe the influences of immediate environments, exploring meaning and sense, interviews and some observations and, especially, a series of photographs taken by a young girl about her daily life were collected. The purpose of this article is to foster a critical debate about the social and developmental consequences that have been attributed to changes in the living conditions of contemporary Western urban children. For the analytical approach and the analysis of the data, it was especially important to take into consideration the characteristics of the case study participant, a high social class 12 year old pre-adolescent who lives in a home where a large variety of information and communication technology equipment is at her disposal. The conclusions that are presented mainly revolve around two issues. First, related to the emergence of multimodal communication situations, of increasingly semiotic complexity, promoted by digital practices visible in different styles of mediation in the uses of technologies identified as: "convergence", "divergence" and "accessibility". Second, that these technological practices facilitate transformations in space, whether public, private or virtual, altering the importance that traditionally held by other places in the processes of socialization of urban children. This article is published in Spanish.

The role of sleep in aesthetic perception and empathy: A mediation analysis.

Science.gov (United States)

Peretti, Sara; Tempesta, Daniela; Socci, Valentina; Pino, Maria C; Mazza, Monica; Valenti, Marco; De Gennaro, Luigi; Di Dio, Cinzia; Marchetti, Antonella; Ferrara, Michele

2018-02-06

The ability to experience aesthetics plays a fundamental role in human social interactions, as well as the capacity to feel empathy. Some studies have shown that beauty perception shares part of the neural network underlying emotional and empathic abilities, which are also known to affect sleep quality and duration. In this study, we evaluated for the first time the effects of sleep on the relation between aesthetic perception and empathic abilities in healthy subjects using a mediation analysis approach. One-hundred and twenty-six subjects participated in this study. One-hundred and one subjects slept at home (Sleep Group). The remaining 25 subjects were tested as controls after 1 night of sleep deprivation to assess the effects of lack of sleep on aesthetic perception and empathy (Sleep-Deprived Group). All participants underwent one testing session in which they performed a battery of empathy tests and an aesthetic perception task (Golden Beauty). The results showed that sleep duration mediates the relationship between empathy and aesthetic perception in the sleep group. The mediation effect of sleep was more evident on the emotional empathy measures. Conversely, in the sleep deprivation group the lack of correlations among empathy, aesthetic perception and sleep variables did not allow to perform the mediation analysis. These results suggest that adequate sleep duration may play a significant role in improving cognitive and emotional empathic abilities as well as the capability to give accurate aesthetic judgements. © 2018 European Sleep Research Society.

COMMITMENT AND BURNOUT: MEDIATOR ROLE OF THE “EMOTIONAL LABOR”

Directory of Open Access Journals (Sweden)

Ayse Esmeray Yogun

2016-04-01

Full Text Available As an undeniable reality of the century, emotional labor is required spesifically in the caring services, where face to face contact is main characteristic of the provided service quality. It is a certain fact that hospitals in need of nurses with high commitment and low burnout more than ever to survive in the chaotic competition market. The main purpose of this paper is to examine the mediating role of the emotional labor on the relationship among nurses‟ commitment and burnout level. To get the required data, Emotional Labor Scale, The Maslach Burnout Inventory and Allen and Meyer‟s Organizational Commitment Scale were used. 500 nurses in Turkey in March 2015-April 2015 were reached. For the analysis of the gathered data, AMOS program, Structural Equation Modeling analysis was employed. In this study it is found that there is a partial mediating role of the emotional labor on the relationship between commitment and burnout. And it is found that there is a negative and moderate impact of commitment on the burnout level of nurses. Finally, practical implications of the gathered results have been given at the end of the paper

The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression.

Directory of Open Access Journals (Sweden)

Nathalie Uwamahoro

Full Text Available The Mediator complex is an essential co-regulator of RNA polymerase II that is conserved throughout eukaryotes. Here we present the first study of Mediator in the pathogenic fungus Candida albicans. We focused on the Middle domain subunit Med31, the Head domain subunit Med20, and Srb9/Med13 from the Kinase domain. The C. albicans Mediator shares some roles with model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, such as functions in the response to certain stresses and the role of Med31 in the expression of genes regulated by the activator Ace2. The C. albicans Mediator also has additional roles in the transcription of genes associated with virulence, for example genes related to morphogenesis and gene families enriched in pathogens, such as the ALS adhesins. Consistently, Med31, Med20, and Srb9/Med13 contribute to key virulence attributes of C. albicans, filamentation, and biofilm formation; and ALS1 is a biologically relevant target of Med31 for development of biofilms. Furthermore, Med31 affects virulence of C. albicans in the worm infection model. We present evidence that the roles of Med31 and Srb9/Med13 in the expression of the genes encoding cell wall adhesins are different between S. cerevisiae and C. albicans: they are repressors of the FLO genes in S. cerevisiae and are activators of the ALS genes in C. albicans. This suggests that Mediator subunits regulate adhesion in a distinct manner between these two distantly related fungal species.

The mediating role of job satisfaction between leader-member exchange and turnover intentions.

Science.gov (United States)

Han, Guohong Helen; Jekel, Marc

2011-01-01

The aim of the present study was to investigate whether job satisfaction mediates between leader-member exchange and nurse turnover intentions. Limited knowledge is available on the mediating role of job satisfaction between leader-member exchange and turnover intentions in the nursing field. This is a cross-sectional survey study. Data were collected in a US hospital. Higher leader-member exchange was associated with lower turnover intentions (β=-0.41, PLeader-member exchange was positively related to one's job satisfaction (β=0.50, Pleader-member exchange and job satisfaction were both controlled for, the link between leader-member exchange and turnover intentions was no longer significant (β=-0.12, P>0.05). Job satisfaction mediates the link between leader-member exchange and turnover intentions. The present study reinforces the significant role of managers. Nurse managers can try to cultivate a good relationship with the nurses. This can enhance nurses' job satisfaction and in turn lower their turnover intentions. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.

Assessing the relationship between technology readiness and continuance intention in an E-appointment system: relationship quality as a mediator.

Science.gov (United States)

Chen, Shih-Chih; Jong, Din; Lai, Min-Tsai

2014-09-01

Numerous types of self-service technologies have prevailed due to innovations in network and information technology. To hospitals, patient intentions to continue to use the e-appointment system are crucial. Previous investigations discussed only the relationships between the technology readiness of users and their continuance intentions, and ignored the most important mediator, relationship quality. This study explored the relationships among technology readiness, relationship quality, and continuance intention. The research results demonstrated that both optimism and innovativeness significantly and positively influenced continuance intention through the mediating effect of relationship quality. However, discomfort and insecurity hid not significantly influence relationship quality or continuance intention. Finally, theoretical contributions, managerial implications and future research directions were discussed.

Peer relationship and adolescent smartphone addiction: The mediating role of self-esteem and the moderating role of the need to belong.

Science.gov (United States)

Wang, Pengcheng; Zhao, Meng; Wang, Xingchao; Xie, Xiaochun; Wang, Yuhui; Lei, Li

2017-12-01

Background and aims Adolescent smartphone addiction has received increased attention in recent years, and peer relationship has been found to be a protective factor in adolescent smartphone. However, little is known about the mediating and moderating mechanisms underlying this relation. The aim of this study was to investigate (a) the mediating role of self-esteem in the association between student-student relationship and smartphone addiction, and (b) the moderating role of the need to belong in the indirect relationship between student-student relationship and adolescent smartphone addiction. Methods This model was examined with 768 Chinese adolescents (mean age = 16.81 years, SD = 0.73); the participants completed measurements regarding student-student relationship, self-esteem, the need to belong, and smartphone addiction. Results The correlation analyses indicated that student-student relationship was significantly negatively associated with adolescent smartphone addiction, and the need to belong was significantly positively associated with adolescent smartphone addiction. Mediation analyses revealed that self-esteem partially mediated the link between student-student relationship and adolescent smartphone addiction. Moderated mediation further indicated that the mediated path was weaker for adolescents with lower levels of the need to belong. Discussion and conclusion High self-esteem could be a protective factor against smartphone addiction for adolescents with a strong need to belong as these students appeared to be at elevated risk of developing smartphone addiction.

An Investigation of Tool Mediation in the Research Activity of Eighth-Grade Students

Science.gov (United States)

Henry, Nancy L.

2016-01-01

Technology and a variety of resources play an important role in students' educational lives. Vygotsky's (1987) theory of tool mediation suggests that cultural tools, such as computer software influence individuals' thinking and action. However, it is not completely understood how technology and other resources influence student action. Middle…

Efficacy of family mediation and the role of family violence: study protocol

Science.gov (United States)

2014-01-01

Background Family law reforms in Australia require separated parents in dispute to attempt mandatory family dispute resolution (FDR) in community-based family services before court attendance. However, there are concerns about such services when clients present with a history of high conflict and family violence. This study protocol describes a longitudinal study of couples presenting for family mediation services. The study aims to describe the profile of family mediation clients, including type of family violence, and determine the impact of violence profiles on FDR processes and outcomes, such as the type and durability of shared parenting arrangements and clients’ satisfaction with mediated agreements. Methods A mixed method, naturalistic longitudinal design is used. The sampling frame is clients presenting at nine family mediation centres across metropolitan, outer suburban, and regional/rural sites in Victoria, Australia. Data are collected at pre-test, completion of mediation, and six months later. Self-administered surveys are administered at the three time points, and a telephone interview at the final post-test. The key study variable is family violence. Key outcome measures are changes in the type and level of acrimony and violent behaviours, the relationship between violence and mediated agreements, the durability of agreements over six months, and client satisfaction with mediation. Discussion Family violence is a major risk to the physical and mental health of women and children. This study will inform debates about the role of family violence and how to manage it in the family mediation context. It will also inform decision-making about mediation practices by better understanding how mediation impacts on parenting agreements, and the implications for children, especially in the context of family violence. PMID:24443936

Efficacy of family mediation and the role of family violence: study protocol.

Science.gov (United States)

Cleak, Helen; Schofield, Margot; Bickerdike, Andrew

2014-01-21

Family law reforms in Australia require separated parents in dispute to attempt mandatory family dispute resolution (FDR) in community-based family services before court attendance. However, there are concerns about such services when clients present with a history of high conflict and family violence. This study protocol describes a longitudinal study of couples presenting for family mediation services. The study aims to describe the profile of family mediation clients, including type of family violence, and determine the impact of violence profiles on FDR processes and outcomes, such as the type and durability of shared parenting arrangements and clients' satisfaction with mediated agreements. A mixed method, naturalistic longitudinal design is used. The sampling frame is clients presenting at nine family mediation centres across metropolitan, outer suburban, and regional/rural sites in Victoria, Australia. Data are collected at pre-test, completion of mediation, and six months later. Self-administered surveys are administered at the three time points, and a telephone interview at the final post-test. The key study variable is family violence. Key outcome measures are changes in the type and level of acrimony and violent behaviours, the relationship between violence and mediated agreements, the durability of agreements over six months, and client satisfaction with mediation. Family violence is a major risk to the physical and mental health of women and children. This study will inform debates about the role of family violence and how to manage it in the family mediation context. It will also inform decision-making about mediation practices by better understanding how mediation impacts on parenting agreements, and the implications for children, especially in the context of family violence.

Cumulative trauma, gender discrimination and mental health in women: mediating role of self-esteem.

Science.gov (United States)

Kucharska, Justyna

2017-12-20

Evidence suggests that women show symptoms of trauma-related symptoms more often than men. Gender discrimination is also associated with the severity of symptoms in women. This study explored the relations among cumulative trauma, gender discrimination and mental health in women with a mediating role of self-esteem and emotion regulation. Two types of gender discrimination were taken into account: discrimination by parents and in the social context. Cumulative trauma over the lifetime was assessed, as well as three types of symptoms: internalising, externalising, psychoticism. A total of 277 females from Poland participated in the study. It was hypothesised that gender discrimination and cumulative trauma would be positively related to symptoms and that lowered self-esteem mediates these relations. Hypotheses received partial confirmation, as both gender discrimination and cumulative trauma have been shown to be related to three types of symptoms. Self-esteem was a partial mediator between gender discrimination in the social context and symptoms. It was also demonstrated that emotion suppression is a partial mediator between cumulative trauma and symptoms. It has been demonstrated that socio-cultural factors, such as gender discrimination, play an important role in psychiatric symptoms development.

Personality and Social Problem-Solving: The Mediating Role of Self-Esteem

Science.gov (United States)

Koruklu, Nermin

2015-01-01

The purpose of the present study was to examine direct and indirect relationships among personality, selfesteem and social problem-solving, as well as the mediating role of self-esteem in the link between personality and social problem-solving among Turkish youth. The study utilized a cross-sectional design comprising several self-reports. Data…

Personality and Attitude towards Teaching Profession: Mediating Role of Self Efficacy

Science.gov (United States)

Üstüner, Mehmet

2017-01-01

The objective of the present study is to examine the correlation between the five factor personality traits of pre-service teachers and their attitudes towards the teaching profession and to test the mediating role of the pre-service teachers' self-efficacy beliefs. The study population included pre-service teachers that attended the…

Understanding the connection between self-esteem and aggression: The mediating role of emotion dysregulation.

Science.gov (United States)

Garofalo, Carlo; Holden, Christopher J; Zeigler-Hill, Virgil; Velotti, Patrizia

2016-01-01

The purpose of the present study was to extend previous knowledge concerning the link between self-esteem and aggression by examining the mediating role of emotion dysregulation among offenders and community participants. A sample of 153 incarcerated violent offenders and a community sample of 197 individuals completed self-report measures of self-esteem level, emotion dysregulation, and trait aggression. Offenders reported lower levels of self-esteem than community participants, as well as greater levels of emotional nonacceptance and hostility. Bootstrapping analyses were performed to test whether emotion dysregulation mediated the association between self-esteem level and aggression. In the offender sample, mediation models were significant for three of the four aspects of trait aggression that were considered. Emotion dysregulation fully mediated the links that low self-esteem had with physical aggression, anger, and hostility. The same pattern (with the addition of full mediation for verbal aggression) was confirmed in the community sample. Our findings suggest that emotion dysregulation may play an important role in the connection between low self-esteem and aggression. Alternative models of the associations among these variables were tested and discussed. As a whole, the present results are consistent with those of other studies and suggest that it may be beneficial to include emotion regulation modules as part of prevention and treatment programs for violent offenders. © 2015 Wiley Periodicals, Inc.

Ambivalent Sexism as a Mediator for Sex Role Orientation and Gender Stereotypes in Romantic Relationships: A Study in Turkey

Directory of Open Access Journals (Sweden)

Ferzan Curun

2017-10-01

Full Text Available The present study examined the mediating effects of ambivalent sexism (hostile and benevolent in the relationship between sex role orientation (masculinity and femininity and gender stereotypes (dominance and assertiveness in college students. The variables were measured using the Bem Sex Role Inventory (BSRI, the Ambivalent Sexism Inventory (ASI, and the Attitudes toward Gender Stereotypes in Romantic Relationships Scale (AGSRRS. These inventories were administered to 250 undergraduate students at Istanbul University in Istanbul and Suleyman Demirel University in Isparta, Turkey. Results indicate that benevolent sexism mediates the relationship between hostile sexism and male dominance. Benevolent sexism also mediates femininity and male dominance, as well as femininity and male assertiveness. Hostile sexism was mediated only between the masculine personality trait and benevolent sexism. The present findings expand the literature on sex role orientation by revealing evidence that masculine and feminine individuals experience ambivalent sexism distinctively. The results are discussed in terms of the assumptions of sex role orientation, ambivalent sexism, and gender stereotypes.

Mediating Role of Knowledge Management in Effect of Management Accounting Practices on Firm Performance

OpenAIRE

David Han-Min Wang; Quang Linh Huynh

2013-01-01

While adopting knowledge management can improve firm performance, it is determined by implementing level of management accounting practices. Furthermore, it plays mediating role in the relationship between implementing management accounting practices and firm performance. This paper employs path analysis to investigate causal relationships among the variables. Then it uses procedures suggested by Sobel (1982) to examine the mediation of adopting knowledge management. Moreover, this paper util...

Coping with Anxiety, Depression, Anger and Aggression: The Mediational Role of Resilience in Adolescents

Science.gov (United States)

Ng, Reuben; Ang, Rebecca P.; Ho, Moon-Ho Ringo

2012-01-01

Background: The New Freedom Commission on Mental Health urged that mental health services be transformed from a reactive approach of treatment to a proactive one of prevention and building resilience. In response, the present study delineates the role of resilience in reducing psychopathology. Objective: The study examined the mediational role of…

Psychological Vulnerability and Problem Gambling: The Mediational Role of Cognitive Distortions.

Science.gov (United States)

Lévesque, David; Sévigny, Serge; Giroux, Isabelle; Jacques, Christian

2018-01-03

Despite numerous studies demonstrating the influence of cognitive distortions on gambling problem severity, empirical data regarding the role of psychological vulnerability on the latter is limited. Hence, this study assesses the mediating effect of cognitive distortions between psychological vulnerability (personality and mood), and gambling problem severity. It also verifies whether the relationships between these variables differs according to the preferred gambling activity. The sample is composed of 272 male gamblers [191 poker players; 81 video lottery terminal (VLT) players] aged between 18 and 82 years (M = 35.2). Bootstrap analysis results revealed that cognitive distortions mediate the effect of narcissism on gambling problem severity for both groups. The level of depression for VLT players significantly predicted gambling problem severity, both directly and indirectly via the mediating effect of cognitive distortions. Mediation analyses also indicated that narcissism had an indirect impact on problem gambling through cognitive distortions for both groups. These findings suggest that certain vulnerabilities related to personality and mood may influence cognitive distortion intensity and gambling problem severity. In addition, psychological vulnerabilities could differ based on preferred gambling activity. These results may be useful for prevention policies, identifying high risk gamblers and planning psychological interventions.

El papel mediador de la Autoeficacia Profesional entre situaciones de Demandas de Rol y Salud Autopercibida (The mediating role of Professional Self-efficacy between Role Demands situations and Self-perceived Health

Directory of Open Access Journals (Sweden)

María Isabel Soler Sánchez

2017-12-01

Full Text Available The aim of this study was to investigate the relationship between role stress, professional self-efficacy, and self-perceived health using the Job Demands-Resources Model (JD-R model. The proposed model hypothesizes that professional self-efficacy mediates the relationship between role ambiguity and role conflict on the one hand, and self-perceived health on the other. To test this hypothesis, data were collected from 272 workers from southern Spain. Mediation analyses were performed using the macro PROCESS for SPSS developed by Hayes (2013. Results showed that role conflict, role ambiguity, and self-efficacy were significant predictors of self-perceived health. In addition, self-efficacy partially mediated the relationship between role stress and health.

Examining the stress-burnout relationship: the mediating role of negative thoughts

Directory of Open Access Journals (Sweden)

Ko-Hsin Chang

2017-12-01

Full Text Available Background Using Smith’s (1986 cognitive-affective model of athletic burnout as a guiding framework, the purpose of this study was to examine the relationships among athletes’ stress in life, negative thoughts, and the mediating role of negative thoughts on the stress-burnout relationship. Methods A total of 300 college student-athletes (males = 174; females = 126, Mage = 20.43 y, SD = 1.68 completed the College Student Athlete’s Life Stress Scale (CSALSS; Lu et al., 2012, the Automatic Thoughts Questionnaire (ATQ; Hollon & Kendall, 1980, and the Athlete Burnout Questionnaire (ABQ; Raedeke & Smith, 2001. Results Correlational analyses found that two types of life stress and four types of negative thoughts correlated with burnout. Additionally, hierarchical regression analyses found that four types of negative thoughts partially mediated the stress-burnout relationship. Discussion We concluded that an athlete’s negative thoughts play a pivotal role in predicting athletes’ stress-burnout relationship. Future study may examine how irrational cognition influences athletes’ motivation and psychological well-being.

Impact of value congruence on work-family conflicts: the mediating role of work-related support.

Science.gov (United States)

Pan, Su-Ying; Yeh, Ying-Jung Yvonne

2012-01-01

Based on past research regarding the relationship between person-environment fit and work-family conflict (WFC), we examined the mediating effects of perceived organization/supervisor support on the relationship between person-organization/supervisor value congruence and WFC. A structural equation model was used to test three hypotheses using data collected from 637 workers in Taiwan. Person-organization value congruence regarding role boundaries was found to be positively correlated with employee perception of organizational support, resulting in reduced WFC. Person-supervisor value congruence regarding role boundaries also increased employee perception of organizational support, mediated by perceived supervisor support. Research and managerial implications are discussed.

How do stressors lead to burnout? The mediating role of motivation.

Science.gov (United States)

Rubino, Cristina; Luksyte, Aleksandra; Perry, Sara Jansen; Volpone, Sabrina D

2009-07-01

We extend existing stressor-strain theoretical models by including intrinsic motivation as a mediator between well-established job stressors and burnout. Though the link between situational stressors and burnout is well established, little is known about mechanisms behind this relationship. With a sample of 284 self-employed individuals, we examined motivation as a mediator to explain why situational factors impact 3 dimensions of burnout: emotional exhaustion, cynicism, and inefficacy. Motivation is an explanatory mechanism that drives human behavior and thought, and thus may have an impact on important well-being outcomes. As expected, intrinsic motivation was a full mediator for the effect of perceived fit on the inefficacy dimension of burnout. Unexpectedly, neither perceived fit nor motivation was related to the other 2 dimensions of burnout, and role ambiguity had only a direct effect on the inefficacy dimension; it was also unrelated to exhaustion and cynicism. We discuss implications of these findings for researchers as well as for practitioners. (c) 2009 APA, all rights reserved.

Innovation Implementation: The Role of Technology Diffusion Agencies

Directory of Open Access Journals (Sweden)

Jasmin Robertson

2008-08-01

Full Text Available A great deal of ‘innovation failure’ can be attributed to ineffective implementation, rather than failure of the innovation itself. External agencies such as technology diffusion agencies (TDAs have been created to assist organisations to implement innovation successfully, but there has been little empirical research investigating their roles. This paper presents a longitudinal case study of failed innovation implementation, and highlights in particular the role that technology diffusion agencies can play to prevent such failure in future cases. Results indicate the importance of changes in organisational factors such as training, climate, and management support during the implementation process in predicting outcomes, and imply a role for TDAs in assisting with both technical and non-technical aspects of innovation implementation.

Role of Mobile Technology in Promoting Campus-Wide Learning Environment

Science.gov (United States)

Hussain, Irshad; Adeeb, Muhammad Aslam

2009-01-01

The present study examines the role of mobile technology in promoting campus-wide learning environment. Its main objectives were to a) evaluate the role of mobile technology in higher education in terms of its i). appropriateness ii). flexibility iii). Interactivity, & iv). availability & usefulness and to b). identify the problems of…

Materialism and addictive buying in women: the mediating role of anxiety and depression.

Science.gov (United States)

Otero-López, José Manuel; Villardefrancos, Estíbaliz

2013-08-01

There is empirical evidence regarding the interrelationships between materialism, negative emotions, and addictive buying. The aim of this study was to clarify the direction of the relationships among these variables. Specifically, the main objective was to explore the possible mediating roles of anxiety and depression in the link between materialism and addictive buying. Path analysis results, using a sample of 685 women, generally supported the suitability of the proposed model in which anxiety and depression mediated the effects of the materialism dimensions, "importance" and "success," on addictive buying, and that depression also mediates the influence of the "importance" and "happiness" dimensions. Moreover, a direct effect of the importance dimension on addictive buying was found.

Sensation seeking and drunk driving: the mediational role of social norms and self-efficacy.

Science.gov (United States)

González-Iglesias, Beatriz; Gómez-Fraguela, José Antonio; Luengo, Ma Ángeles

2014-10-01

The aim of this work was to examine the role of sensation seeking in drunk driving by youths, and the potential mediational effect of social, cognitive and emotional variables on their relationship. To this end, a survey was conducted on 274 drivers (164 females and 110 males) aged 24.36±2.96 years (range 18-30 years). The results obtained confirm the significance of sensation seeking to drunk driving by youths and the mediating role of biased self-efficacy perceptions in their relationship. The important practical implications of this finding on the development of effective interventions to prevent the risks of drunk driving in youths are discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

Different Perspectives on Technology Acceptance: The Role of Technology Type and Age

Science.gov (United States)

Arning, Katrin; Ziefle, Martina

Although eHealth technologies offer an enormous potential to improve healthcare, the knowledge about key determinants of acceptance for eHealth technology is restricted. While the underlying technology of eHealth technologies and Information and Communication technology (ICT) is quite similar, utilization contexts and using motives are quite different. In order to explore the role of technology type on acceptance, we contrasted central application characteristics of both technology types using the scenario technique. A questionnaire was administered (n = 104) measuring individual variables (age, gender) and attitudes regarding an eHealth application (blood sugar meter) in contrast to an ICT device (Personal Digital Assistant, PDA). Older users basically approved the utilization of health-related technologies and perceived lower usability barriers. In addition, we identified main utilization motives of eHealth technology and technology-specific acceptance patterns, especially regarding issues of data safety in the eHealth context. Effects of age and gender in acceptance ratings suggest a differential perspective on eHealth acceptance. Finally, practical interventions were derived in order to support eHealth device design and to promote acceptance of eHealth technology.

Emotional Eating Mediates the Relationship Between Role Stress and Obesity in Clergy.

Science.gov (United States)

Manister, Nancy N; Gigliotti, Eileen

2016-04-01

The purpose of this study was to investigate the relationships between role stress, emotional eating, and obesity in clergy. A random sample of United States Lutheran Church Missouri Synod clergy who met the study criteria (N = 430), response rate 38%, completed the Role Stress and Emotional Eating Behavior Scales, and self-reported height and weight for Body Mass Index (BMI) calculation. Obesity was high (81.4% overweight/obese, 36.7% obese), and emotional eating partially mediated the relationship between role stress and obesity. This study tested relations of the Neuman Systems Model. © The Author(s) 2016.

(Injustice contexts and work satisfaction: The mediating role of justice perceptions

Directory of Open Access Journals (Sweden)

Zhou, Q.

2012-01-01

Full Text Available This study explores the impact of the social context, namely (injustice climate and target, in workers' justice perceptions and satisfaction. Individual's justice judgments are expected to mediate the relationship of (injustice climate and target with work satisfaction. We found mediation effects of procedural justice in the relationship between justice climate and satisfaction, and interactional justice in the relationship between injustice target and satisfaction. Distributive justice does not affect the relationship between the (injustice context and satisfaction. Findings demonstrate the relevance of framing organizational justice in a socially contextualized perspective since they seem to influence individual justice reactions and work attitudes. Using an experimental methodology, it was possible to explore the role of seldom studied contextual variables.

The mediating role of absorptive capacity in knowledge transfer

DEFF Research Database (Denmark)

Adisa, Femi; Rose, Jeremy

2013-01-01

. These problems become acute in implementations in small and medium sized enterprises (SMEs). SMEs often operate with non-standard business processes, making an effective interchange of process knowledge between consultants and end-users crucial. Using a multiple case study method and content analysis......, the authors investigate the mediating role of absorptive capacity in knowledge transfer in SMEs ERP implementations. They present exploratory case studies from 3 Nigerian companies with varying outcomes, and hypothesize that knowledge transfer is complicated by acute information asymmetry, absence of pre...

Evolving technologies drive the new roles of Biomedical Engineering.

Science.gov (United States)

Frisch, P H; St Germain, J; Lui, W

2008-01-01

Rapidly changing technology coupled with the financial impact of organized health care, has required hospital Biomedical Engineering organizations to augment their traditional operational and business models to increase their role in developing enhanced clinical applications utilizing new and evolving technologies. The deployment of these technology based applications has required Biomedical Engineering organizations to re-organize to optimize the manner in which they provide and manage services. Memorial Sloan-Kettering Cancer Center has implemented a strategy to explore evolving technologies integrating them into enhanced clinical applications while optimally utilizing the expertise of the traditional Biomedical Engineering component (Clinical Engineering) to provide expanded support in technology / equipment management, device repair, preventive maintenance and integration with legacy clinical systems. Specifically, Biomedical Engineering is an integral component of the Medical Physics Department which provides comprehensive and integrated support to the Center in advanced physical, technical and engineering technology. This organizational structure emphasizes the integration and collaboration between a spectrum of technical expertise for clinical support and equipment management roles. The high cost of clinical equipment purchases coupled with the increasing cost of service has driven equipment management responsibilities to include significant business and financial aspects to provide a cost effective service model. This case study details the dynamics of these expanded roles, future initiatives and benefits for Biomedical Engineering and Memorial Sloan Kettering Cancer Center.

A Mediational Model Explaining the Connection Between Religiosity and Anti-Homosexual Attitudes in Italy: The Effects of Male Role Endorsement and Homosexual Stereotyping.

Science.gov (United States)

Piumatti, Giovanni

2017-01-01

This study aimed to better understand the relationship between religiosity and anti-homosexual attitudes in Italy by examining the mediation effects of male role endorsement and homosexual stereotyping. A sample of 5,522 Italian residents (age range = 18-74) was drawn from a cross-sectional national representative survey carried out in 2011. Measures included general religiosity, male role endorsement, homosexual stereotyping, social acceptance of homosexuality, and homosexual rights endorsement. Structural equation modeling was used to test the mediational effects of male role endorsement and homosexual stereotyping on the relationship between general religiosity and attitudes toward lesbians and gay men. Results showed that both male role endorsement and homosexual stereotyping partially mediated the relationship. In a model where religiosity and both mediators positively explained anti-homosexual attitudes, male role endorsement was the strongest mediator. Endorsement of gender role beliefs and homosexual stereotyping may thus exacerbate the connection between religiosity and anti-homosexual attitudes among Italians.

Childhood trauma and eating psychopathology: a mediating role for dissociation and emotion dysregulation?

Science.gov (United States)

Moulton, Stuart J; Newman, Emily; Power, Kevin; Swanson, Vivien; Day, Kenny

2015-01-01

The present study examined the relationship between different forms of childhood trauma and eating psychopathology using a multiple mediation model that included emotion dysregulation and dissociation as hypothesised mediators. 142 female undergraduate psychology students studying at two British Universities participated in this cross-sectional study. Participants completed measures of childhood trauma (emotional abuse, physical abuse, sexual abuse, emotional neglect and physical neglect), eating psychopathology, dissociation and emotion dysregulation. Multiple mediation analysis was conducted to investigate the study's proposed model. Results revealed that the multiple mediation model significantly predicted eating psychopathology. Additionally, both emotion dysregulation and dissociation were found to be significant mediators between childhood trauma and eating psychopathology. A specific indirect effect was observed between childhood emotional abuse and eating psychopathology through emotion dysregulation. Findings support previous research linking childhood trauma to eating psychopathology. They indicate that multiple forms of childhood trauma should be assessed for individuals with eating disorders. The possible maintaining role of emotion regulation processes should also be considered in the treatment of eating disorders. Copyright © 2014 Elsevier Ltd. All rights reserved.

Future Ready Learning: Reimagining the Role of Technology in Education. 2016 National Education Technology Plan

Science.gov (United States)

Thomas, Susan

2016-01-01

The National Education Technology Plan is the flagship educational technology policy document for the United States. The 2016 Plan, "Future Ready Learning: Reimagining the Role of Technology in Education," articulates a vision of equity, active use, and collaborative leadership to make everywhere, all-the-time learning possible. While…

Teaching-Learning Conceptions and Academic Achievement: The Mediating Role of Test Anxiety

Science.gov (United States)

Bas, Gökhan

2016-01-01

The current research aimed at examining the mediating role of test anxiety in the relationship between teaching-learning conceptions and academic achievement. The correlation investigation model was adopted in this research. The participants of the research were volunteering teachers (n = 108) and students (n = 526) from five different high…

The Relationship between Psychological Safety and Employee Voice: The Mediation Role of Affective Commitment and Intrinsic Motivation

Directory of Open Access Journals (Sweden)

Özlem YAŞAR UĞURLU

2016-03-01

Full Text Available In this quantitative research, we enhance understanding of psychological safety on employee voice behavior by examining mediating role of affective commitment and intrinsic motivation. We examined these relationships among 151 research assistants working full-time for universities. The results suggest that psychological safety is significantly associated with affective commitment whereas it does not significantly influence intrinsic motivation. Furthermore, employee voice behavior is affected by intrinsic motivation but not by affective commitment. Lastly, while affective commitment plays an important role as mediator in the relationship between psychological safety and employee voice although intrinsic motivation does not have a mediating effect. We discuss the implications of these findings for both theory and practice.

The role of HSP70 in mediating age-dependent mortality in sepsis

Science.gov (United States)

McConnell, Kevin W.; Fox, Amy C.; Clark, Andrew T.; Chang, Nai-Yuan Nicholas; Dominguez, Jessica A.; Farris, Alton B.; Buchman, Timothy G.; Hunt, Clayton R.; Coopersmith, Craig M.

2011-01-01

Sepsis is primarily a disease of the aged, with increased incidence and mortality occurring in aged hosts. Heat shock protein (HSP) 70 plays an important role in both healthy aging and the stress response to injury. The purpose of this study was to determine the role of HSP70 in mediating mortality and the host inflammatory response in aged septic hosts. Sepsis was induced in both young (6–12week old) and aged (16–17 month old) HSP70−/− and wild type (WT) mice to determine if HSP70 modulated outcome in an age-dependent fashion. Young HSP70−/− and WT mice subjected to cecal ligation and puncture (CLP), Pseudomonas aeruginosa pneumonia or Streptococcus pneumoniae pneumonia had no differences in mortality, suggesting HSP70 does not mediate survival in young septic hosts. In contrast, mortality was higher in aged HSP70−/− mice than aged WT mice subjected to CLP (p=0.01), suggesting HSP70 mediates mortality in sepsis in an age-dependent fashion. Compared to WT mice, aged septic HSP70−/− mice had increased gut epithelial apoptosis and pulmonary inflammation. In addition, HSP70−/−mice had increased systemic levels of TNF-α, IL-6, IL-10 and IL-1β compared to WT mice. These data demonstrate that HSP70 is a key determinant of mortality in aged but not young hosts in sepsis. HSP70 may play a protective role in an age-dependent response to sepsis by preventing excessive gut apoptosis and both pulmonary and systemic inflammation. PMID:21296977

Developing Personalised Education for Personal Mobile Technologies with the Pluralisation Agenda

Science.gov (United States)

Kucirkova, Natalia; Littleton, Karen

2017-01-01

This paper makes a distinctive contribution to the current debates concerning the role of personal mobile technologies (PMTs) in public education. It does this through drawing attention to the imperative to integrate digitally-mediated personalised education with teacher-mediated pluralised education. Premised on the notion that children's…

Burnout and health among critical care professionals: The mediational role of resilience.

Science.gov (United States)

Arrogante, Oscar; Aparicio-Zaldivar, Eva

2017-10-01

To analyse the mediational role of resilience in relationships between burnout and health in critical care professionals; to determine relationships among resilience level, three burnout dimensions, and physical/mental health; and to establish demographic differences in psychological variables evaluated. Cross-sectional study. A total of 52 critical care professionals, mainly nurses, were recruited from an intensive care unit of Madrid (Spain). All participants were assessed with the questionnaires 10-item Connor-Davidson Resilience Scale, Maslach Burnout Inventory-Human Services Survey, and Short Form-12 Health Survey. No demographic differences were found. Three burnout dimensions were negatively associated with mental health and resilience. Mediational analyses revealed resilience mediated 1) the relationships between emotional exhaustion and depersonalisation with mental health (partial mediations) and 2) the relationship between personal accomplishment and mental health (total mediation). Resilience minimises and buffers the impact of negative outcomes of workplace stress on mental health of critical care professionals. As a result, resilience prevents the occurrence of burnout syndrome. Resilience improves not only their mental health, but also their ability to practice effectively. It is therefore imperative to develop resilience programs for critical care nurses in nursing schools, universities and health centres. Copyright © 2017 Elsevier Ltd. All rights reserved.

Technology development in road construction, how government roles affect project performance

NARCIS (Netherlands)

Caerteling, Jasper

2008-01-01

This dissertation contributes to both the academic and policy debates on the roles of government in technology development in the public sector. In the literature, there are many perspectives that deal with government’s roles in technology development. These perspectives include competition,

Peer Support and Adolescents' Physical Activity: The Mediating Roles of Self-Efficacy and Enjoyment.

Science.gov (United States)

Chen, Han; Sun, Haichun; Dai, Jun

2017-06-01

The present study aimed to contrast the mediating magnitude of self-efficacy and enjoyment connecting peer support and adolescents' physical activity (PA). Participants were 9th-12th grade students ( N  = 409; 56.5% boys) who were randomly chosen from six public schools located in Fuzhou city in southeast China. The bootstrapping method in structural equation modeling was conducted to examine the direct and indirect effects of peer support on adolescents' PA. Peer support did not directly impact PA. Rather, peer support indirectly influenced PA through either self-efficacy or enjoyment, with self-efficacy demonstrating a stronger mediating effect. Additionally, we found a significant serial mediating effect with enjoyment, and self-efficacy sequentially mediated the relationship between peer support and PA. The findings highlight the role of self-efficacy and enjoyment as mediators connecting peer support and PA. Self-efficacy seems to be more important, as it demonstrated a significantly greater mediating effect. © The Author 2017. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

The Information and Communication Technology User Role: Implications for the Work Role and Inter-Role Spillover.

Science.gov (United States)

Piszczek, Matthew M; Pichler, Shaun; Turel, Ofir; Greenhaus, Jeffrey

2016-01-01

Management and organization research has traditionally focused on employees' work role and the interface between their work and family roles. We suggest that persons assume a third role in modern society that is relevant to work and organizations, namely the Information and Communication Technology User (ICTU) role. Based on role theory and boundary theory, we develop propositions about the characteristics of this role, as well as how ICTU role characteristics are related to boundary spanning activity, inter-role spillover with the work role, and work role performance. To this end, we first conceptualize the ICTU role and its associations with work and family roles. We then apply identity theory and boundary management theory to advance our understanding of how the ICTU role is related to criteria that are important to individuals and to organizations, namely self-selection into certain types of work roles and positive and negative inter-role spillover. The implications of this role for theory, research, and practice in management and organizations are discussed.

THE ROLE OF INFORMATION TECHNOLOGY IN ORGANIZATIONS

OpenAIRE

Ramin Bashir Khodaparasti

2012-01-01

Development of organization started in period with agriculture and industrial during the period came and information. Today in period of competition, information is very important needed. So competitive advantage in the information provided to achieve goals is necessary. Entrance of this technology in organizations conjectural attitude changed and evolved functions their managers. The purpose of this paper is to define the correct information and the role technology has in improving the situa...

The Mediating Role of Materialism on the Relationship between Values and Consumption

Science.gov (United States)

Sevgili, Fatma; Cesur, Sevim

2014-01-01

The main aim of this study is to investigate the relationship between values and consumption, and to adduce the mediating roles of materialism in this association. Values have been investigated through Schwartz's main value dimensions in his Theory of Human Values: Self-Enhancement, Self-Transcendence, Openness to Change and Conservation. Through…

Antimicrobial aspects of inflammatory resolution in the mucosa: A role for pro-resolving mediators1

Science.gov (United States)

Campbell, Eric L.; Serhan, Charles N.; Colgan, Sean P.

2011-01-01

Mucosal surfaces function as selectively permeable barriers between the host and the outside world. Given their close proximity to microbial antigens, mucosal surfaces have evolved sophisticated mechanisms for maintaining homeostasis and preventing excessive acute inflammatory reactions. The role attributed to epithelial cells was historically limited to serving as a selective barrier, in recent years numerous findings implicate an active role of the epithelium with pro-resolving mediators in the maintenance of immunological equilibrium. In this brief review, we highlight new evidence that the epithelium actively contributes to coordination and resolution of inflammation, principally through the generation of anti-inflammatory and pro-resolution lipid mediators. These autacoids, derived from ω-6 and ω-3 polyunsaturated fatty acids, are implicated in the initiation, progression and resolution of acute inflammation and display specific, epithelial-directed actions focused on mucosalhomeostasis. We also summarize present knowledge of mechanisms for resolution via regulation of epithelial-derived antimicrobial peptides in response to pro-resolving lipid mediators. PMID:21934099

The effect of animated images on persuasion: The mediator role of hedonic responses and the moderator role of product category

OpenAIRE

Hussant-Zebian, Rola

2004-01-01

This paper aims to highlight the mediator role of hedonic responses in the relation between animated images and attitudinal responses. It has another objective which is to show off the moderator role of product category. To this purpose, we have manipulated two categories of advertising opposing computer animated to non-computer animated images. We have also seetwo product categories : a high involvement product and a low involvement one.

Internet addiction, adolescent depression, and the mediating role of life events: finding from a sample of Chinese adolescents.

Science.gov (United States)

Yang, Linsheng; Sun, Liang; Zhang, Zhihua; Sun, Yehuan; Wu, Hongyan; Ye, Dongqing

2014-10-01

The aim of this study is to examine the mediating role of life events in the relation between Internet addiction and depression using an adolescent sample in China. A total of 3507 urban adolescent students were asked to complete the questionnaires including Young's Internet Addiction Scale, Adolescent Self-Rating Life Events Checklist, and Center for Epidemiologic Studies Depression Scale, Parent-Child Conflict Tactics Scales, and demographic characteristics. Path analyses demonstrated that life events fully mediated the relationship between Internet addiction and adolescent depression. Specificity for the mediating role of life events was demonstrated in comparison to alternative competing mediation models. The findings support our hypothesis that the effect of Internet addiction on adolescent depression is mediated by the life events. Further research is required to test the temporal relationship between Internet addiction and adolescent depression and explore mechanisms underlying the pathways leading to adolescent depression. © 2014 International Union of Psychological Science.

Childhood Maltreatment, Depressive Symptoms, and Body Dissatisfaction in Patients with Binge Eating Disorder: The Mediating Role of Self-Criticism

Science.gov (United States)

Dunkley, David M.; Masheb, Robin M.; Grilo, Carlos M.

2010-01-01

Objective We examined the mediating role of self-criticism in the relation between childhood maltreatment and both depressive symptoms and body dissatisfaction in patients with binge eating disorder (BED). Method Participants were 170 BED patients who completed measures of childhood maltreatment, self-criticism, self-esteem, depressive symptoms, and body dissatisfaction. Results Specific forms of childhood maltreatment (emotional abuse, sexual abuse) were significantly associated with body dissatisfaction. Path analyses demonstrated that self-criticism fully mediated the relation between emotional abuse and both depressive symptoms and body dissatisfaction. Specificity for the mediating role of self-criticism was demonstrated in comparison to other potential mediators (low self-esteem) and alternative competing mediation models. Conclusion These results highlight self-criticism as a potential mechanism through which certain forms of childhood maltreatment may be associated with depressive symptoms and body dissatisfaction in BED patients. PMID:20119938

[Effects of nurses' mentoring on turnover intention: focused on the mediating effects role stress and burnout].

Science.gov (United States)

Han, Sangsook; Kim, Ohsook; Joo, Yunsu; Choi, Eunduck; Han, Jeongwon

2013-10-01

The purpose of this study was to investigate the casual relationship between nurses' mentoring and turnover intention and to verify the goodness of fit between a hypothetical model and actual data in order to suggest an adequate model. The survey was conducted with 434 nurses working in general hospitals in Seoul. Data were collected during February 2013, and analyzed with SPSS Windows 18.0 and AMOS 7.0. Mentoring was found to have a direct effect on decrease in role stress. Role stress had a direct effect on increase in burnout and mentoring, with role stress as a mediator, there was an indirect effect on burnout. Burnout had a direct effect on increase in turnover intention, and role stress, with burnout as a mediator, and mentoring, through role stress and burnout, an indirect effect was found on increase in turnover intention. The results of this study indicate that nursing managers should put effort into reducing role stress and burnout, while seeking to establish a more efficient mentoring system so that for nurses, there will be a lowering of turnover intention.

The mediating role of metacognitive variables in the relationship between Thought-Action Fusion and obsessive-compulsive symptomatology

Directory of Open Access Journals (Sweden)

Paula Odriozola-González

2016-07-01

Full Text Available Diverse studies support the central role of Thought-Action Fusion (TAF and other metacognitive variables in the understanding of obsessive-compulsive disorder (OCD symptomatology. However, a more detailed study of the involvement of these variables is needed. This article seeks to assess the possible mediating role of the factors of the Metacognitions Questionnaire (MCQ in the relationship between TAF and OCD symptoms both in clinical and non-clinical samples. A cross-sectional design was used in which 120 participants, divided into three groups (two clinical and one non-clinical, completed the questionnaires assessing the constructs of interest. The mediational findings generally supported the proposed mediation model. Specifically, the mediational analyses focused on negative beliefs and the need to control (metacognitive factors of the MCQ showed that MCQ Negative beliefs mediated the effects of TAF-Total and TAF factors (except for the TAF-Moral on OCD symptomatology in the OCD group. The MCQ Need to control was non-significant as a mediator of the relationships between TAF and OCD. However, it was observed that this mediation approached significance, with considerable effect sizes. In the clinical-control group, the analyses showed that MCQ Negative beliefs mediated the effects of TAF-Likelihood-Oneself on OCD symptoms. In the remaining group, neither MCQ Negative beliefs nor MCQ Need to control were found to be significant mediators. It is generally concluded that certain beliefs, such as TAF, can evolve toward more complex metacognitive beliefs, which ultimately lead to the development of OCD symptoms.

Mediator or moderator? The role of mindfulness in the association between child behavior problems and parental stress.

Science.gov (United States)

Chan, Tim Oi; Lam, Shui-Fong

2017-11-01

Raising a child with intellectual disability (ID) may be stressful for parents. Previous studies have suggested the mediating role of mindfulness in the association between child behavior problems and parental stress. The present study examined whether this mediating role is a result of parents' self-report bias. It also explored whether mindfulness has a moderating role instead when child behavior problems are reported by teachers. In a questionnaire survey, 271 Chinese parents of children with ID in 6 Hong Kong special schools reported their levels of stress and mindfulness, as well as their children's behavior problems. The latter was also reported by teachers. When child behavior problems were reported by parents, parental mindfulness was a mediator between child behavior problems and parental stress. In contrast, when child behavior problems were reported by teachers, parental mindfulness was a moderator between child behavior problems and parental stress. The mediation role of mindfulness maybe an artifact of measurement. The findings provide an encouraging message that parenting a child with ID and behavior problems does not necessarily mean more stress among all parents. Parents with a high level of mindfulness may experience less stress than those with a low level of mindfulness. Parents of children with intellectual disability (ID) tend to report high psychological stress. Previous self-report studies have identified mindfulness as a mediator in the association between child behavior problems and parental stress. The present study differs from previous studies by including third-party's reports. It has contributed to the existing body of knowledge in two respects. First, it examined whether the mediation effect resulted from parent self-report bias. Second, it tested an alternative hypothesis of the moderation effect by using teachers' reports to measure child behavior problems. The results showed that when child behavior problems were measured by parents

THE MEDIATING ROLE OF ROMANTIC RELATIONSHIPS BETWEEN OPTIMISM AND DEPRESSION IN EMERGING ADULTS

Directory of Open Access Journals (Sweden)

Elena Cattelino

2014-04-01

Full Text Available The existing literature showed that higher depression is linked to less optimism and to poor quality of romantic relationship, but studies considering the role of both optimism and romantic relationship on depression among emerging adults are lacking. The aims of the study were: 1 to describe the quality of romantic relationship, optimism and depression in a group of Italian emerging adults; 2 to examine the relation between optimism and depression; 3 to investigate the possible mediating role of quality of romantic relationship on the relation between optimism and depression. The study involved 228 emerging adults (59% girls, aged from 18 to 22 (mean age= 19.5, standard deviation=1.2. Optimism was assessed through the Life Orientation Test-Revised (LOT-R; Scheier et al., 1994, depression through the Center for Epidemiologic Studies Short Depression Scale (CES-D 10; Andresen et al., 1994 and quality of romantic relationships through the Romance Qualities Scale (RQS; Ponti et al., 2010. Main results showed a partial mediating effect of quality of romantic relationship between optimism and depression: less optimistic emerging adults reported higher depression, but the effect of lack of optimism was mediated by a good relationship with the partner. Implications for theory and practice were discussed.

The Big Five personality dimensions and mental health: The mediating role of alexithymia.

Science.gov (United States)

Atari, Mohammad; Yaghoubirad, Mahsa

2016-12-01

The role of personality constructs on mental health has attracted research attention in the last few decades. The Big Five personality traits have been introduced as parsimonious dimensions of non-pathological traits. The five-factor model of personality includes neuroticism, agreeableness, conscientiousness, extraversion, and openness to experience. The present study aimed to examine the relationship between the Big Five dimensions and mental health considering the mediating role of alexithymia as an important emotional-processing construct. A total of 257 participants were recruited from non-clinical settings in the general population. All participants completed the Ten-Item Personality Inventory (TIPI), 20-item Toronto Alexithymia Scale (TAS-20), and General Health Questionnaire-28 (GHQ-28). Structural equation modeling was utilized to examine the hypothesized mediated model. Findings indicated that the Big Five personality dimensions could significantly predict scores of alexithymia. Moreover, alexithymia could predict mental health scores as measured by indices of depression, anxiety, social functioning, and somatic symptoms. The fit indices (GFI=0.94; CFI=0.91; TLI=0.90; RMSEA=0.071; CMIN/df=2.29) indicated that the model fits the data. Therefore, the relationship between the Big Five personality dimensions and mental health is mediated by alexithymia. Copyright © 2016 Elsevier B.V. All rights reserved.

Relationships between the Advertising Appeal and Behavioral Intention: The Mediating role of the Attitude towards Advertising Appeal

Directory of Open Access Journals (Sweden)

Raza Syed Hassan

2017-01-01

Full Text Available The link between the advertising appeal, attitude and behavioral intention is dynamic in nature, however, little research has been pursued towards explaining the mediating role of attitude towards the advertising in link of the advertising appeal with the behavioral intention. Researchers have identified the importance of the attitude in the connection of the advertising appeal within the framework of the (TPB which remains unaddressed in the explicating the mediation of the attitude in relationship of advertising appeal and behavioral intention. This paper aims to provide insight of the attitude towards the advertising as the mediating factor in explaining the relationship between the advertising appeal and behavioral intention. In addition, this paper is only a theoretical exploration, it is expected that this work lead towards an explanation of the mediating role of the attitude to address the relation of advertising appeal and intention which may be studied further to determine the empirical finding about the other dynamic of the (TPB.

The Benefits of Social Technology Use Among Older Adults Are Mediated by Reduced Loneliness

Science.gov (United States)

2016-01-01

Abstract Technology has the ability to enhance and enrich the lives of older adults by facilitating better interpersonal relationships. However, few studies have directly examined associations between technology use for social reasons and physical and psychological health among older adults. The current study examines the benefits of technology use in 591 older adults from the 2012 wave of the Health and Retirement Study (Mage = 68.18, SD = 10.75; 55.5% female). Social technology use was assessed through five technology-based behaviors (i.e., using e-mail, social networking sites, online video/phone calls, online chatting/instant messaging, using a smartphone). Attitudes toward the usability and benefits of technology use were also assessed. Older adults had generally positive attitudes toward technology. Higher social technology use was associated with better self-rated health, fewer chronic illnesses, higher subjective well-being, and fewer depressive symptoms. Furthermore, each of the links between social technology use and physical and psychological health was mediated by reduced loneliness. Close relationships are a large determinant of physical health and well-being, and technology has the potential to cultivate successful relationships among older adults. PMID:27541746

The Benefits of Social Technology Use Among Older Adults Are Mediated by Reduced Loneliness.

Science.gov (United States)

Chopik, William J

2016-09-01

Technology has the ability to enhance and enrich the lives of older adults by facilitating better interpersonal relationships. However, few studies have directly examined associations between technology use for social reasons and physical and psychological health among older adults. The current study examines the benefits of technology use in 591 older adults from the 2012 wave of the Health and Retirement Study (Mage = 68.18, SD = 10.75; 55.5% female). Social technology use was assessed through five technology-based behaviors (i.e., using e-mail, social networking sites, online video/phone calls, online chatting/instant messaging, using a smartphone). Attitudes toward the usability and benefits of technology use were also assessed. Older adults had generally positive attitudes toward technology. Higher social technology use was associated with better self-rated health, fewer chronic illnesses, higher subjective well-being, and fewer depressive symptoms. Furthermore, each of the links between social technology use and physical and psychological health was mediated by reduced loneliness. Close relationships are a large determinant of physical health and well-being, and technology has the potential to cultivate successful relationships among older adults.

The Mediating Roles of Anxiety Depression, and Hopelessness on Adolescent Suicidal Behaviors

Science.gov (United States)

Thompson, Elaine Adams; Mazza, James J.; Herting, Jerald R.; Randell, Brooke P.; Eggert, Leona L.

2005-01-01

The purpose of this study was to explore the roles of anxiety, depression, and hopelessness as mediators between known risk factors and suicidal behaviors among 1,287 potential high school dropouts. As a step toward theory development, a model was tested that posited the relationships among these variables and their effects on suicidal behaviors.…

The mediating role of pain acceptance during mindfulness-based cognitive therapy for headache.

Science.gov (United States)

Day, Melissa A; Thorn, Beverly E

2016-04-01

This study aimed to determine if mindfulness-based cognitive therapy (MBCT) engenders improvement in headache outcomes via the mechanisms specified by theory: (1) change in psychological process, (i.e., pain acceptance); and concurrently (2) change in cognitive content, (i.e., pain catastrophizing; headache management self-efficacy). A secondary analysis of a randomized controlled trial comparing MBCT to a medical treatment as usual, delayed treatment (DT) control was conducted. Participants were individuals with headache pain who completed MBCT or DT (N=24) at the Kilgo Headache Clinic or psychology clinic. Standardized measures of the primary outcome (pain interference) and proposed mediators were administered at pre- and post-treatment; change scores were calculated. Bootstrap mediation models were conducted. Pain acceptance emerged as a significant mediator of the group-interference relation (pMediation models examining acceptance subscales showed nuances in this effect, with activity engagement emerging as a significant mediator (pmediation due to a non-significant pathway from the mediator to outcome. Criteria for mediation was also not met for the catastrophizing or self-efficacy models as neither of these variables significantly predicted pain interference. Pain acceptance, and specifically engagement in valued activities despite pain, may be a key mechanism underlying improvement in pain outcome during a MBCT for headache pain intervention. The theorized mediating role of cognitive content factors was not supported in this preliminary study. A large, definitive trial is warranted to replicate and extend the findings in order to streamline and optimize MBCT for headache. Copyright © 2016 Elsevier Ltd. All rights reserved.

The mediated effects of maternal depression and infant temperament on maternal role.

Science.gov (United States)

Rode, Jennifer L; Kiel, Elizabeth J

2016-02-01

We examined prenatal depression, postpartum depression, and infant temperament, respectively, in a mediated process model to predict maternal role. Using a prospective, observational design, we surveyed 168 women during pregnancy and then in postpartum. Data analyses supported the contribution of each variable in an ascending fashion (ab = -0.01, SE = 0.004, 95 % CI [-0.021, -0.004]), such that infant temperament had the strongest effects (sr(2) = .124, p maternal role with both direct effects and indirect effects via infant temperament. These results highlighted the significant impact postpartum depression may have on maternal role. Future interventions targeting mothers experiencing or who are at risk for depression may consider tools to improve mother-baby interactions. The effects of such intervention may subsequently improve both infant temperament and maternal role evaluation.

The Role of Mediators in the Indirect Effects of Religiosity on Therapeutic Compliance in African Migrant HIV-Positive Patients.

Science.gov (United States)

Mambet Doue, Constance; Roussiau, Nicolas

2016-12-01

This research investigates the indirect effects of religiosity (practice and belief) on therapeutic compliance in 81 HIV-positive patients who are migrants from sub-Saharan Africa (23 men and 58 women). Using analyses of mediation and standard multiple regression, including a resampling procedure by bootstrapping, the role of these mediators (magical-religious beliefs and nonuse of toxic substances) was tested. The results show that, through magical-religious beliefs, religiosity has a negative indirect effect, while with the nonuse of toxic substances, religious practice has a positive indirect effect. Beyond religiosity, the role of mediators is highlighted in the interaction with therapeutic compliance.

Idiosyncratic deals and employee outcomes: the mediating roles of social exchange and self-enhancement and the moderating role of individualism.

Science.gov (United States)

Liu, Jun; Lee, Cynthia; Hui, Chun; Kwan, Ho Kwong; Wu, Long-Zeng

2013-09-01

The majority of studies on idiosyncratic employment arrangements ("i-deals") are based on social exchange theory. The authors suggest that self-enhancement theory, in addition to social exchange, can be used to explain the effects of i-deals. Using a multisource sample including 230 employees and 102 supervisors from 2 Chinese companies, the authors adopt a 3-wave lagged design to examine the mediating roles of social exchange and self-enhancement and the moderating role of individualism in the relationships between i-deals and employee outcomes, as indicated by proactive behaviors and affective commitment. The results of bootstrapping analyses confirm the mediating effects of social exchange and self-enhancement. In addition, employees with high levels of individualism are more receptive to self-enhancement effects; in contrast, employees with low levels of individualism are more receptive to social exchange effects. PsycINFO Database Record (c) 2013 APA, all rights reserved

Mediating Role of Mindfulness on the Associations of Friendship Quality and Subjective Vitality.

Science.gov (United States)

Akin, Umran; Akin, Ahmet; Uğur, Erol

2016-10-01

This research investigated the mediator role of mindfulness on the relationship between friendship quality and subjective vitality. Participants were 273 university students (M age = 21 years, SD = 1.1) who completed a questionnaire package that included the Friendship Quality Scale, the Cognitive and Affective Mindfulness Scale, and the Subjective Vitality Scale. Both mindfulness and subjective vitality were correlated positively with friendship quality and subjective vitality was correlated positively with mindfulness. Mindfulness mediated the relationship between friendship quality and subjective vitality. Together, the findings illuminate the importance of friendship quality in psychological and cognitive adjustment. © The Author(s) 2016.

Job hindrances, job resources, and safety performance: The mediating role of job engagement.

Science.gov (United States)

Yuan, Zhenyu; Li, Yongjuan; Tetrick, Lois E

2015-11-01

Job engagement has received widespread attention in organizational research but has rarely been empirically investigated in the context of safety. In the present study, we examined the mediating role of job engagement in the relationships between job characteristics and safety performance using self-reported data collected at a coal mining company in China. Most of our study hypotheses were supported. Job engagement partially mediated the relationships between job resources and safety performance dimensions. Theoretical and practical implications and directions for future research are also discussed. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

AAV Vectorization of DSB-mediated Gene Editing Technologies.

Science.gov (United States)

Moser, Rachel J; Hirsch, Matthew L

2016-01-01

Recent work both at the bench and the bedside demonstrate zinc-finger nucleases (ZFNs), CRISPR/Cas9, and other programmable site-specific endonuclease technologies are being successfully utilized within and alongside AAV vectors to induce therapeutically relevant levels of directed gene editing within the human chromosome. Studies from past decades acknowledge that AAV vector genomes are enhanced substrates for homology-directed repair in the presence or absence of targeted DNA damage within the host genome. Additionally, AAV vectors are currently the most efficient format for in vivo gene delivery with no vector related complications in >100 clinical trials for diverse diseases. At the same time, advancements in the design of custom-engineered site-specific endonucleases and the utilization of elucidated endonuclease formats have resulted in efficient and facile genetic engineering for basic science and for clinical therapies. AAV vectors and gene editing technologies are an obvious marriage, using AAV for the delivery of repair substrate and/or a gene encoding a designer endonuclease; however, while efficient delivery and enhanced gene targeting by vector genomes are advantageous, other attributes of AAV vectors are less desirable for gene editing technologies. This review summarizes the various roles that AAV vectors play in gene editing technologies and provides insight into its trending applications for the treatment of genetic diseases.

The Mediating Role of School Motivation in Linking Student Victimization and Academic Achievement

Science.gov (United States)

Fan, Weihua; Dempsey, Allison G.

2017-01-01

This study examined the mediating role of student school motivation in linking student victimization experiences and academic achievement among a nationally representative sample of students in 10th grade. Structural equation modeling supported that there were significant associations between student victimization and academic achievement for high…

DMPD: Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derivedinflammatory mediators. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available l) (.csml) Show Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derivedinflammatory mediator...egulation of dendritic cell-derivedinflammatory mediators. Authors Harizi H, Gualde N. Publication Cell Mol ...16978535 Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derivedinflammatory mediat...ors. Harizi H, Gualde N. Cell Mol Immunol. 2006 Aug;3(4):271-7. (.png) (.svg) (.htm

From goal motivation to goal progress: the mediating role of coping in the Self-Concordance Model.

Science.gov (United States)

Gaudreau, Patrick; Carraro, Natasha; Miranda, Dave

2012-01-01

The present studies examined the mediating role of self-regulatory mechanisms in the relationship between goal motivation and goal progress in the Self-Concordance Model. First, a systematic review, using meta-analytical path analysis, supported the mediating role of effort and action planning in the positive association between autonomous goal motivation and goal progress. Second, results from two additional empirical studies, using structural equation modeling, lent credence to the mediating role of coping in the relationship between goal motivation and goal progress of university students. Autonomous goal motivation was positively associated with task-oriented coping, which predicted greater goal progress during midterm exams (Study 1, N=702) and at the end of the semester in a different sample (Study 2, N=167). Controlled goal motivation was associated with greater disengagement-oriented coping (Study 1 and Study 2) and lesser use of task-oriented coping (Study 2), which reduced goal progress. These results held up after controlling for perceived stress (Study 2). Our findings highlight the importance of coping in the "inception-to-attainment" goal process because autonomous goal motivation indirectly rather than directly predicts goal progress of university students through their usage of task-oriented coping.

Attachment and Parenting: The Mediating Role of Work-Family Balance in Portuguese Parents of Preschool Children

Science.gov (United States)

Vieira, Joana Marina; AVila, Marisa; Matos, Paula Mena

2012-01-01

Given the increasingly challenging task of balancing multiple adult life roles in contemporary society, this study examined the influences of both conflicting and (positively) synergistic work and family roles in mediating associations between the quality of adult attachment and both parental satisfaction and parenting stress. Participants were…

Work-family conflict and burnout among Chinese doctors: the mediating role of psychological capital.

Science.gov (United States)

Wang, Yang; Liu, Li; Wang, Jiana; Wang, Lie

2012-01-01

The aim of this study was to investigate the relation between work-family conflict and burnout, and the mediating role of psychological capital (PsyCap) in the relation between work-family conflict and burnout, among Chinese doctors. This cross-sectional study was performed during the period of September/October 2010. A questionnaire that comprised work-family conflict assessed by the work-family conflict scale, PsyCap assessed by the PCQ-24 scale and burnout assessed by the Maslach Burnout Inventory-General Survey (MBI-GS), as well as age and gender, was distributed to 1,300 doctors in Liaoning Province, China. A total of 1,011 effective respondents became our final study subjects. Hierarchical linear regression analyses were performed by using SPSS 17.0 to explore the mediating role of PsyCap in the relation between work-family conflict and burnout. Both work interfering family conflict (WIF) and family interfering work conflict (FIW) were positively related with emotional exhaustion and cynicism among both male and females doctors. However, WIF was positively related with professional efficacy only among male doctors, whereas FIW was negatively related with professional efficacy among both male and female doctors. PsyCap partially mediated the relation between WIF and professional efficacy among male doctors and partially mediated the relations of FIW with emotional exhaustion, cynicism and professional efficacy among female doctors. Work-family conflict was associated with burnout among Chinese doctors. PsyCap was a mediator between work-family conflict and burnout. PsyCap might be a positive resource to reduce the negative effect of work-family conflict on burnout of doctors, especially female doctors, in China.

The public role in promoting child health information technology.

Science.gov (United States)

Conway, Patrick H; White, P Jonathan; Clancy, Carolyn

2009-01-01

The public sector plays an important role in promoting child health information technology. Public sector support is essential in 5 main aspects of child health information technology, namely, data standards, pediatric functions in health information systems, privacy policies, research and implementation funding, and incentives for technology adoption. Some innovations in health information technology for adult populations can be transferred to or adapted for children, but there also are unique needs in the pediatric population. Development of health information technology that addresses children's needs and effective adoption of that technology are critical for US children to receive care of the highest possible quality in the future.

The role of new technologies in risks from natural hazards

International Nuclear Information System (INIS)

Gardner, J.S.

1982-01-01

The author places some prior natural hazards research into the context of risk from new technologies to show that some beneficial technologies increase the risk from natural hazards. He examines the role of new technologies in risks from natural hazards in a historical perspective, using examples from research on mountain hazards

The role of technological innovation in sustainable economic development

OpenAIRE

Andreea Constantinescu; Simona Frone

2014-01-01

As in science an accurate picture of present is highlighted from a future outlook, we should recognize the crucial role of new technologies and innovation to improve knowledge in this field. They may give guarantee of sustainable economic development, provided prioritization of research in some fields such as: information technology and communication, resource depletion and climate change. Technological innovation becomes support of all strategies and policies aimed at ensuring sustainable ec...

Role of light in the mediation of acute effects of a single afternoon ...

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 25; Issue 3. Role of light in the mediation of acute effects of a single afternoon melatonin injection on steroidogenic activity of testis in the rat. Saumen K Maitra Arun K Ray. Articles Volume 25 Issue 3 September 2000 pp 253-256 ...

The relationship between leader-follower exchange and job insecurity: The mediating role of trust

Directory of Open Access Journals (Sweden)

Olufemi Adigun Lawal

2016-07-01

Full Text Available The study examines the extent and nature of mediational roles of affective and cognitive trusts on the predictive relationship between leader-member exchange (LMX and job insecurity. Six hundred and twenty-six employees are surveyed through questionnaire administration. Analysis of the data is done with simple regression and multiple regression analyses. The findings show no significant prediction of job insecurity by affective trust as well as no significant mediation of the LMX and job insecurity relationship by affective trust. The study also shows significant prediction of job insecurity by LMX, and significant mediation of the LMX-job insecurity relationship by cognitive trust. The results are discussed in the light of reviewed literature and current realities. The implications of the study are also highlighted.

The Big Five Personality Traits and French Firefighter Burnout: The Mediating Role of Achievement Goals.

Science.gov (United States)

Vaulerin, Jérôme; Colson, Serge S; Emile, Mélanie; Scoffier-Mériaux, Stéphanie; d'Arripe-Longueville, Fabienne

2016-04-01

We investigated the associations between the Big Five personality traits and occupational burnout in firefighters and the mediating role of achievement goals in this relationship. Two hundred twenty male firefighters from 20 to 62 years old participated and mediation analyses were performed. The results showed that neuroticism was positively related to the three dimensions of burnout, both directly and through mastery avoidance goals. Mastery approach goals mediated the relationships between conscientiousness and physical fatigue and between openness to experience and physical fatigue. Three of the Big Five personality traits, neuroticism, conscientiousness and openness to experience, and achievement goals, may be important factors in understanding and preventing firefighter burnout.

Parent-adolescent attachment and procrastination: The mediating role of self-worth.

Science.gov (United States)

Chen, Bin-Bin

2017-01-01

Within the theoretical framework of attachment theory, the author examined associations between adolescents' procrastination and their attachment relationships with both mothers and fathers, and explored the potential mediation role of self-worth in these associations. Participants were 384 Chinese adolescents (49.6% boys, average age 15.13 years) from public schools in Shanghai, China. They completed self-report measures of 3 dimensions of parental attachment (i.e., trust, communication, and alienation), general self-worth, and procrastination. The results indicated that both paternal and maternal trust and paternal communication were negatively associated with higher levels of procrastination whereas both paternal and maternal alienation were positively associated with procrastination. In addition, self-worth mediated the associations among 3 dimensions of parental attachment and procrastination. The findings highlighted the importance of parental attachment-based intervention strategies to reduce procrastination among adolescents.

The Mediating Role of Anticipated Guilt in Consumers’ Ethical Decision-Making

OpenAIRE

S. STEENHAUT; P. VAN KENHOVE

2006-01-01

In this paper we theorize that the anticipation of guilt plays an important role in ethically questionable consumer situations. We propose an ethical decision-making framework incorporating anticipated guilt as partial mediator between consumers’ ethical beliefs (anteceded by ethical ideology) and intentions. In a first study we compared several models using structural equation modeling and found empirical support for our research model. A second experiment was set up to illustrate how retail...

The Impact of Transformational Leadership on Employee Sustainable Performance: The Mediating Role of Organizational Citizenship Behavior

Directory of Open Access Journals (Sweden)

Weiping Jiang

2017-09-01

Full Text Available Transformational leadership has drawn extensive attention in management research. In this field, the influence of transformational leadership on employee performance is an important branch. Recent research indicates that organizational citizenship behavior plays a mediating role between transformational leadership and employee performance. However, some of these findings contradict each other. Given the background where greater attention is being paid to transformational leadership in the construction industry, this research aims to find the degree of the influence of transformational leadership on employee sustainable performance, as well as the mediating role of organizational citizenship behavior. A total of 389 questionnaires were collected from contractors and analyzed via structural equation modeling. The findings reveal that employee sustainable performance is positively influenced by transformational leadership. In addition, more than half of that influence is mediated by their organizational citizenship behavior. These findings remind project managers of the need to pay close attention to transformational leadership, to cultivate organizational citizenship behavior, and thereby to eventually improve employee’s sustainable performance.

Representation of Cultural Role-Play for Training

Science.gov (United States)

Santarelli, Thomas; Pepe, Aaron; Rosenzweiz, Larry; Paulus, John; Yi, Ahn Na

2010-01-01

The Department of Defense (000) has successfully applied a number of methods for cultural familiarization training ranging from stand-up classroom training, to face-to-face live role-play, to so-called smart-cards. Recent interest has turned to the use of single and mUlti-player gaming technologies to augment these traditional methods of cultural familiarization. One such system, termed CulturePad, has been designed as a game-based role-play environment suitable for use in training and experimentation involving cultural roleplay scenarios. This paper describes the initial CulturePad effort focused on a literature review regarding the use of role-play for cultural training and a feasibility assessment of using a game-mediated environment for role-play. A small-scale pilot involving cultural experts was conducted to collect qualitative behavioral data comparing live role-play to game-mediated role-play in a multiplayer gaming engine.

End-point effector stress mediators in neuroimmune interactions: their role in immune system homeostasis and autoimmune pathology.

Science.gov (United States)

Dimitrijevic, Mirjana; Stanojevic, Stanislava; Kustrimovic, Natasa; Leposavic, Gordana

2012-04-01

Much evidence has identified a direct anatomical and functional link between the brain and the immune system, with glucocorticoids (GCs), catecholamines (CAs), and neuropeptide Y (NPY) as its end-point mediators. This suggests the important role of these mediators in immune system homeostasis and the pathogenesis of inflammatory autoimmune diseases. However, although it is clear that these mediators can modulate lymphocyte maturation and the activity of distinct immune cell types, their putative role in the pathogenesis of autoimmune disease is not yet completely understood. We have contributed to this field by discovering the influence of CAs and GCs on fine-tuning thymocyte negative selection and, in particular, by pointing to the putative CA-mediated mechanisms underlying this influence. Furthermore, we have shown that CAs are implicated in the regulation of regulatory T-cell development in the thymus. Moreover, our investigations related to macrophage biology emphasize the complex interaction between GCs, CAs and NPY in the modulation of macrophage functions and their putative significance for the pathogenesis of autoimmune inflammatory diseases.

THE ROLE OF THE SOCIAL MEDIATOR WITHIN THE DISABILITY EMPLOYMENT SUPPORT SYSTEM

Directory of Open Access Journals (Sweden)

Maria Dorina PASCA

2014-04-01

Full Text Available For people with disabilities, to find a way to improve life quality by having a job and by developing independent living skills is a “sine qua non” condition for their social integration. The social mediator working within a disability employment support system facilitates the logistic implementation of a viable and plausible program, which can identify, and maintain a workplace for people with disabilities, and acts as a motivational guarantee of these persons’ chance for a better life while also providing life lessons to all of us. Hence, the major role of the social mediator is to develop a new cognitive structure of communication for disabled people so that they can act as our equals and not as marginalized human beings.

Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme*

Science.gov (United States)

Sato, Shigeo; Tomomori-Sato, Chieri; Tsai, Kuang-Lei; Yu, Xiaodi; Sardiu, Mihaela; Saraf, Anita; Washburn, Michael P.; Florens, Laurence; Asturias, Francisco J.; Conaway, Ronald C.

2016-01-01

Mediator plays an integral role in activation of RNA polymerase II (Pol II) transcription. A key step in activation is binding of Mediator to Pol II to form the Mediator-Pol II holoenzyme. Here, we exploit a combination of biochemistry and macromolecular EM to investigate holoenzyme assembly. We identify a subset of human Mediator head module subunits that bind Pol II independent of other subunits and thus probably contribute to a major Pol II binding site. In addition, we show that binding of human Mediator to Pol II depends on the integrity of a conserved “hinge” in the middle module MED21-MED7 heterodimer. Point mutations in the hinge region leave core Mediator intact but lead to increased disorder of the middle module and markedly reduced affinity for Pol II. These findings highlight the importance of Mediator conformation for holoenzyme assembly. PMID:27821593

Designing business rules for mediation : a process towards agent-mediated business coordination

OpenAIRE

Zhao, Z.; Dignum, M.V.; Dignum, F.P.M.

2008-01-01

Business process integration is a very active research area, in which mediation is one of the fundamental architectural choices. Mediators have difficulties to design mediation services that meet the requirements of the different stakeholders. Business rules play an important role in the decision process of mediation. In this paper, we analyze the role of business rules in the decision process, and use some examples to illustrate how business rules should be designed in order to help the deci...

Teacher’s Autonomy Support and Engagement in Math: Multiple Mediating Roles of Self-efficacy, Intrinsic Value, and Boredom

Science.gov (United States)

Wang, Jia; Liu, Ru-De; Ding, Yi; Xu, Le; Liu, Ying; Zhen, Rui

2017-01-01

Previous studies have highlighted the impacts of environmental factors (teacher’s autonomy support) and individual factors (self-efficacy, intrinsic value, and boredom) on academic engagement. This study aimed to investigate these variables and examine the relations among them. Three structural equation models tested the multiple mediational roles of self-efficacy, intrinsic value, and boredom in the relation between teacher’s autonomy support and behavioral, emotional, and cognitive engagement, respectively, in math. A total of 637 Chinese middle school students (313 males, 324 females; mean age = 14.82) voluntarily participated in this study. Results revealed that self-efficacy, intrinsic value, and boredom played important and mediating roles between perceived teacher’s autonomy support and student engagement. Specifically, these three individual variables partly mediated the relations between perceived teacher’s autonomy support and behavioral and cognitive engagement, while fully mediating the relation between perceived teacher’s autonomy support and emotional engagement. These findings complement and extend the understanding of factors affecting students’ engagement in math. PMID:28690560

Fibroblasts in fibrosis: novel roles and mediators

Directory of Open Access Journals (Sweden)

Ryan Thomas Kendall

2014-05-01

Full Text Available Fibroblasts are the most common cell type of the connective tissues found throughout the body and the principal source of the extensive extracellular matrix (ECM characteristic of these tissues. They are also the central mediators of the pathological fibrotic accumulation of ECM and the cellular proliferation and differentiation that occurs in response to prolonged tissue injury and chronic inflammation. The transformation of the fibroblast cell lineage involves classical developmental signaling programs and includes a surprisingly diverse range of precursor cell types—most notably, myofibroblasts that are the apex of the fibrotic phenotype. Myofibroblasts display exaggerated ECM production; constitutively secrete and are hypersensitive to chemical signals such as cytokines, chemokines, and growth factors; and are endowed with a contractile apparatus allowing them to manipulate the ECM fibers physically to close open wounds. In addition to ECM production, fibroblasts have multiple concomitant biological roles, such as in wound healing, inflammation, and angiogenesis, which are each interwoven with the process of fibrosis. We now recognize many common fibroblast-related features across various physiological and pathological protracted processes. Indeed, a new appreciation has emerged for the role of noncancerous fibroblast interactions with tumors in cancer progression. Although the predominant current clinical treatments of fibrosis involve nonspecific immunosuppressive and anti-proliferative drugs, a variety of potential therapies under investigation specifically target fibroblast biology.

Materialism and well-being among Chinese college students: the mediating role of basic psychological need satisfaction.

Science.gov (United States)

Chen, Yongjie; Yao, Meilin; Yan, Wenfan

2014-10-01

Based on self-determination theory, this study explored the potential mediating role of basic psychological need satisfaction in the relationship between materialism and well-being among Chinese college students. The results showed that basic psychological need satisfaction partially mediated the relationship between materialism and life satisfaction and fully mediated the relationships among materialism and emotional well-being, subjective vitality, and self-actualization. The findings indicated the importance of considering both subjective and psychological well-being and the interpretative power of basic psychological need satisfaction and Chinese culture in the flow from materialism to well-being. © The Author(s) 2013.

Mediating Role of Perceived Organizational Support on the Impact of Psychol ogical Capital on Organizational Identification

Directory of Open Access Journals (Sweden)

Haluk Erdem

2015-06-01

Full Text Available Employees’ loyalty toward organizations is decreasing gradually recently. This phenomenon negatively affects the dimensions of organizational behavior directly or indirectly. In this study, the effect of psychological capital on organizational identification, and the mediating role of perceived org anizational support in this association are explored. Thereby, data based on the government employees in Bitlis Province (n=478 are analyzed (exploratory and confirmatory factor analyses, regression analysis and it is supported that psychological capital increases positively and significantly perceived organizational support and organizational identification. Besides, the mediating role of organizational support in the association between psychological capital and organizational identification is supporte d using tree step regression analysis and Sobel Test

Linking Childhood Maltreatment to Substance Use in College Students: The Mediating Role of Self-Worth Contingencies.

Science.gov (United States)

Kim, Jungmeen; Williams, Sarah

2009-01-01

This study investigated the link between childhood maltreatment and substance use focusing on examining contingencies of self-worth (CSW) as mediators among college students (N = 513). Structural equation modeling indicated that childhood sexual abuse among females was related to lower God's love CSW, which in turn was related to higher levels of cigarette, marijuana, and other illicit drug use, supporting the mediational role of God's love CSW. Correlational analyses demonstrated that, for both male and female students, external contingency of appearance was related to higher substance use, whereas internal contingencies of God's love and virtue were related to lower substance use. The findings highlight the protective role of internal CSW in substance use among females with childhood sexual abuse.

The Mediating Role of Family on the Effects of Brand Preferences of Consumer-Based Brand Equity

Directory of Open Access Journals (Sweden)

Erkan YILDIZ

2015-06-01

Full Text Available The primary objective of this study is to investigate the effects of the sub-dimension of consumer-based brand equity which are called brand awareness, perceived quality, brand associations and brand loyalty on brand preference and the second goal is to find out the mediating role of family on these relations. For this purpose, a study was conducted with the participation of 295 people in Ankara. According to the research result, perceived quality and brand loyalty positively effects on brand preferences but there is no significant effect of brand awareness and brand association on these preferences. And also it is observed that family does not have any mediating role on these relations.

The role of aquatic fungi in transformations of organic matter mediated by nutrients

Science.gov (United States)

Cynthia J. Tant; Amy D. Rosemond; Andrew S. Mehring; Kevin A. Kuehn; John M. Davis

2015-01-01

1. We assessed the key role of aquatic fungi in modifying coarse particulate organic matter (CPOM) by affecting its breakdown rate, nutrient concentration and conversion to fine particulate organic matter (FPOM). Overall, we hypothesised that fungal-mediated conditioning and breakdown of CPOM would be accelerated when nutrient concentrations are increased and tested...

Parenting Styles and Bullying at School: The Mediating Role of Locus of Control

Science.gov (United States)

Georgiou, Stelios N.; Ioannou, Myria; Stavrinides, Panayiotis

2017-01-01

The current study examined the mediating role of children's locus of control in the relation between parenting styles and bully-victim experiences at school. Participants were 447 students aged 10 and 11 years old from 13 different elementary, urban, and rural schools in Cyprus. Analyses using structural equation modeling showed that parenting…

The role of heat shock protein 70 in mediating age-dependent mortality in sepsis.

Science.gov (United States)

McConnell, Kevin W; Fox, Amy C; Clark, Andrew T; Chang, Nai-Yuan Nicholas; Dominguez, Jessica A; Farris, Alton B; Buchman, Timothy G; Hunt, Clayton R; Coopersmith, Craig M

2011-03-15

Sepsis is primarily a disease of the aged, with increased incidence and mortality occurring in aged hosts. Heat shock protein (HSP) 70 plays an important role in both healthy aging and the stress response to injury. The purpose of this study was to determine the role of HSP70 in mediating mortality and the host inflammatory response in aged septic hosts. Sepsis was induced in both young (6- to 12-wk-old) and aged (16- to 17-mo-old) HSP70(-/-) and wild-type (WT) mice to determine whether HSP70 modulated outcome in an age-dependent fashion. Young HSP70(-/-) and WT mice subjected to cecal ligation and puncture, Pseudomonas aeruginosa pneumonia, or Streptococcus pneumoniae pneumonia had no differences in mortality, suggesting HSP70 does not mediate survival in young septic hosts. In contrast, mortality was higher in aged HSP70(-/-) mice than aged WT mice subjected to cecal ligation and puncture (p = 0.01), suggesting HSP70 mediates mortality in sepsis in an age-dependent fashion. Compared with WT mice, aged septic HSP70(-/-) mice had increased gut epithelial apoptosis and pulmonary inflammation. In addition, HSP70(-/-) mice had increased systemic levels of TNF-α, IL-6, IL-10, and IL-1β compared with WT mice. These data demonstrate that HSP70 is a key determinant of mortality in aged, but not young hosts in sepsis. HSP70 may play a protective role in an age-dependent response to sepsis by preventing excessive gut apoptosis and both pulmonary and systemic inflammation.

Balancing competing needs mediates the association of caregiving demand with caregiver role strain and depressive symptoms of dementia caregivers: A cross-sectional study.

Science.gov (United States)

Liu, Hsin-Yun; Yang, Ching-Tzu; Wang, Yu-Nu; Hsu, Wen-Chuin; Huang, Tzu-Hsin; Lin, Yueh-E; Liu, Chin-Yi; Shyu, Yea-Ing L

2017-12-01

To examine the role of balancing competing needs in the relationship between caregiving demand and caregiving outcomes (caregivers' role strain and depressive symptoms). Caregivers who do not balance competing needs are more likely to experience negative caregiving outcomes, suggesting that balance mediates between caregiving demand and caregiving outcomes. Identifying a mediator of negative caregiving effects may help in developing tailored interventions for family caregivers of persons with dementia. A cross-sectional, correlational design. Data were collected from family caregivers' self-completed questionnaires between March 2013 - April 2014. A convenience sample of 120 family caregivers and care receivers with dementia was enrolled. We examined whether balance mediated the relationship between caregiving demand and caregiving outcomes (caregivers' role strain and depressive symptoms) by multiple regression analysis. To evaluate the significance of the indirect effect of caregiver balance, we used the Sobel test and Monte Carlo method, an alternative approach to testing mediation. Balancing competing needs completely mediated the association of caregiving demand with depressive symptoms and partially mediated the association of caregiving demand with role strain. Assessing caregivers' self-perceived sense of balance may help to identify caregivers at high risk for role strain and depressive symptoms. Interventions to enhance caregivers' perceived sense of balance between competing needs may provide a strategy for reducing the negative effects of caregiving. © 2017 John Wiley & Sons Ltd.

The mediating role of total quality management between entrepreneurial orientation and SMEs export performance

Directory of Open Access Journals (Sweden)

Muhammad Imran

2018-06-01

Full Text Available The purpose of this study was to investigate the mediating role of total quality management (TQM between entrepreneurial orientation (EO and SME export performance in the manufacturing sector of Pakistan. This study was originated from the fact that only a few studies have examined on how the firm’s intangible resources and capabilities such as EO and TQM drive SMEs’ export performance. Some questionnaires in Likert scale were used to collect the data and 364 usable responses were received from the owner/managers of exporting SMEs. Partial Least Squares Structural Equation Modeling (PLS-SEM was used for the data analysis. The findings reveal significant relationship between EO and TQM with SME export performance. Furthermore, this study found the complementary mediating role of TQM between EO and SME export performance of manufacturing sector of Pakistan. This study has implications for owner/managers of SMEs. The results offer a better understanding regarding EO and TQM implementation to SMEs owner / managers. Thus, owner/managers of SMEs can take better decisions for the implementation of TQM practices. Furthermore, to the best of researcher’s knowledge, this study is the first work, which examines Pakistan`s SMEs export performance in association with the TQM as the mediating factor between EO and SME export performance.

Between Assessments, Digital Technologies and Big Data: The Growing Influence of "Hidden" Data Mediators in Education

Science.gov (United States)

Hartong, Sigrid

2016-01-01

The past few decades have witnessed a global enforcement of "governance by data" in education policy, including a significant increase of assessments and quantified evaluation. Within this context, this article focuses particularly on the intensifying evolvement of new (digital) information technologies and "mediated"…

The Effects of the Mediation and Leadership Role of Tour Guides on the Tour Experience: A Research on Nature Tours

Directory of Open Access Journals (Sweden)

F Özlem GÜZEL

2014-12-01

Full Text Available Other than being a profession that extends beyond only providing information on the historical monuments, tour guiding is a job that has positive effects on the holistic holiday experience. Thus, this profession in its context embodies many different roles that are necessary. With this context, the purpose of this study is primarily to analyze the effects of the leadership and mediation roles on certificated tour guide performance evaluation and then on holistic tour experience. Consequently, in order to determine the relationships between parameters, a field survey at Sarigerme tourism region was conducted on the guided nature tours during the months of May, June and July in 2013. Through the data obtained by the questionnaires, the relationship between the leadership role / mediator role of tour guides on tour guides‟ performance and holistic tour experience basing on two different models was analyzed with Structural Equation Method (SEM. As an outcome of the survey, it was found that the leadership role/mediator role of tour guides on the evaluation of the tour guides‟ performance and that the tour guide performance has positive effects on the evaluation holistic tour experience

Understanding the connection between self-esteem and aggression : The mediating role of emotion dysregulation

NARCIS (Netherlands)

Garofalo, C.; Holden, C.J.; Zeigler-Hill, V.; Velotti, P.

2016-01-01

The purpose of the present study was to extend previous knowledge concerning the link between self-esteem and aggression by examining the mediating role of emotion dysregulation among offenders and community participants. A sample of 153 incarcerated violent offenders and a community sample of 197

Trait Procrastination, Self-Efficacy and Achievement Goals: The Mediation Role of Boredom Coping Strategies

Science.gov (United States)

Zhou, Mingming; Kam, Chester Chun Seng

2017-01-01

Limited research has examined the mediational role of coping strategy in students' motivation and procrastination. In this study, we examined the relationships among self-efficacy, achievement goals, boredom coping strategies and procrastination with 506 Chinese college students. Data were collected via questionnaires. Structural equation…

Technology Trust and E-Banking Adoption: The Mediating Effect of Customer Relationship Management Performance

Directory of Open Access Journals (Sweden)

Samsudin Wahab

2012-01-01

Full Text Available The electronic revolution in the Malaysian banking sector has started in the 1970's. The first visible form of electronic innovation in the Malaysian banking industry was the introduction of Automated Teller Machines in 1981. Finally, on June 1, 2000, the Malaysian Central Bank gave the green light for locally owned commercial banks to offer Internet banking services. Due to the drastic changes in the business environment, it leads financial institutions to revise their marketing strategies to stress long-lasting relationships with customers. Relationships is important criteria in the selection of private bank. In many conditions, customer satisfaction mediates the relationship between antecedent’s factors and marketing performance. Hence, CRM performance is about maintaining good relationship and repurchases behavior, word-of-mouth and customer retention. Trust has been studied in traditional physical commercial environments. In the marketing and management literatures, trust is strongly associated with attitudes toward products, services, and purchasing behaviors. So that, the main objective of this research paper is to investigate the role of CRM performance as the mediator in the relationship between trust and E-Banking adoption. Hence, this empirical paper confirmed the role of customer relationship management performance as the mediators in the relationship between trust and electronic banking adoption.Key words: Trust, Customer Relationship Management Performance, E-Banking Adoption

The Influence of the Paralympic Sponsorship on Consumers' Purchase Intention: The Mediating Role of Corporate Image

Directory of Open Access Journals (Sweden)

Sang Back Nam

2013-01-01

Full Text Available The purpose of the current study was to investigate the influence of Paralympic sponsorship on corporate image and consumer purchase intension, and the mediating role of corporate image between sponsorship and purchase intention was examined. Furthermore, it was to investigate which dimension of corporate image plays as the mediating role in the relationship between Paralympic sponsorship and consumer purchase intention. 400 data were collected from residents of Seoul, Incheon, Busan, and Kwangju, Korea from December 20th, 2010 to January 10th, and 384 data were used. The data were analyzed by using SPSS/PC ver. 15.0 for Windows and AMOS 7.0 program. The mediating effects were tested by using Bootrapping method. The significance level was set at á = .05, and the results are as follows. First, promotion and contribution dimensions of Paralympic sponsorship had positive effects on corporate image. Second, Paralympic sponsorship had positive effects on consumers' purchase intention. Third, among corporate image dimensions, only corporate contribution image had positive effects on consumers' purchase intention. Fourth, corporate contribution dimension was partially mediating in the relationship between promotion dimension of Paralympic sponsorship and consumers' purchase intention and contribution dimension of Paralympic sponsorship and consumers'purchase intention.

Utilization of internet technology by low-income adults: the role of health literacy, health numeracy, and computer assistance.

Science.gov (United States)

Jensen, Jakob D; King, Andy J; Davis, LaShara A; Guntzviller, Lisa M

2010-09-01

To examine whether low-income adults' utilization of Internet technology is predicted or mediated by health literacy, health numeracy, and computer assistance. Low-income adults (N = 131) from the midwestern United States were surveyed about their technology access and use. Individuals with low health literacy skills were less likely to use Internet technology (e.g., email, search engines, and online health information seeking), and those with low health numeracy skills were less likely to have access to Internet technology (e.g., computers and cell phones). Consistent with past research, males, older participants, and those with less education were less likely to search for health information online. The relationship between age and online health information seeking was mediated by participant literacy. The present study suggests that significant advances in technology access and use could be sparked by developing technology interfaces that are accessible to individuals with limited literacy skills.

The roles and functions of a lunar base Nuclear Technology Center

International Nuclear Information System (INIS)

Buden, D.; Angelo, J.A. Jr.

1991-01-01

This paper describes the roles and functions of a special Nuclear Technology Center which is developed as an integral part of a permanent lunar base. Numerous contemporary studies clearly point out that nuclear energy technology will play a major role in any successful lunar/Mars initiative program and in the overall establishment of humanity's solar system civilization. The key role of nuclear energy in the providing power has been recognized. A Nuclear Technology Center developed as part of of a permanent lunar base can also help bring about many other nuclear technology applications, such as producing radioisotopes for self-illumination, food preservation, waste sterilization, and medical treatment; providing thermal energy for mining, materials processing and agricultural; and as a source of emergency habitat power. Designing such a center will involve the deployment, operation, servicing and waste product management and disposal of megawatt class reactor power plants. This challenge must be met with a minimum of direct human support at the facility. Furthermore, to support the timely, efficient integration of this Nuclear Technology Center in the evolving lunar base infrastructure, an analog of such a facility will be needed here on Earth. 12 refs., 4 figs., 1 tab

The influence of gender on entrepreneurial intention: The mediating role of perceptual factors

Directory of Open Access Journals (Sweden)

Carmen Camelo-Ordaz

2016-10-01

Full Text Available The empirical evidence devoted to analyze the impact of perceptual factors in explaining the differences in the entrepreneurial intention of men and women is still limited and not entirely conclusive (Shinnar et al., 2012; Wilson et al., 2009. This non-conclusive research is significantly more noteworthy when the analysis is focused on the entrepreneurial intention of men and women once they become entrepreneurs. Drawing on this gap and taking as starting point the premises of Social Feminist Theory, our paper aims to examine the mediating role of perceptual factors on the relationship between gender and entrepreneurial intention of non-entrepreneurs and entrepreneurs. Drawing on a sample provided by the Global Entrepreneurship Monitor Project of 21,697 Spanish non-entrepreneurs and 2899 Spanish entrepreneurs, our results have shown that, in general terms, perceptual factor fully mediate the relationship between gender and the entrepreneurial intention of non-entrepreneurs, whereas such mediating impact disappears when people become entrepreneurs.

Motivation toward Physical Exercise and Subjective Wellbeing: The Mediating Role of Trait Self-Control

Directory of Open Access Journals (Sweden)

Walid Briki

2016-10-01

Full Text Available Motivation toward physical exercise (MPE and trait self-control (TSC were identified as key predictors of subjective wellbeing (SWB. However, there has not been any research designed to examine the mediating role of TSC in the relationship between MPE and SWB. The present study utilizes self-determination theory, control-process theory of self-regulation, and theory of multiple pathways of TSC in order to examine whether TSC mediates the relationships of autonomous MPE (A-MPE, controlled MPE (C-MPE, and impersonal MPE (NO-MPE with SWB using structural equation modeling (XLSTAT PLS. Three hundred seventeen adult American individuals (Mage = 32.97, SDage = 11.30, who reported to be regular exercisers, voluntarily answered questionnaires assessing MPE, TSC, and SWB. Correlational analyses revealed positive relationships between A-MPE, TSC, and SWB, and negative relationships of C-MPE and NO-MPE with TSC and SWB. Mediation analyses revealed that TSC mediated the relationships of A-MPE (partial mediation and C-MPE (full mediation with SWB, but did not mediate the relationship between NO-MPE and SWB. The estimates of the quality of the hypothesized model were acceptable (outer model GoF = .935; absolute GoF = .330; relative GoF = .942; inner model GoF = 1.008; R2 = 36.947%. Finally, this study supports the view that MPE can influence SWB through TSC, and incites to pursue the examination of the relationships between self-determined motivation, self-regulation mechanisms, and health-related outcomes.

The role of surgeons in identifying emerging technologies for health technology assessment.

Science.gov (United States)

Stafinski, Tania; Topfer, Leigh-Ann; Zakariasen, Ken; Menon, Devidas

2010-04-01

Health technology assessment (HTA) is a tool intended to help policy-makers decide which technologies to fund. However, given the proliferation of new technologies, it is not possible to undertake an HTA of each one before it becomes funded. Consequently, "horizon-scanning" processes have been developed to identify emerging technologies that are likely to have a substantial impact on clinical practice. Although the importance of physicians in the adoption of new technologies is well recognized, their role in horizon scanning in Canada has been limited. The purpose of this project was to pilot an approach to engage physicians, specifically surgeons, in provincial horizon-scanning activities. We invited 18 surgeons from Alberta's 2 medical schools to a horizon-scanning workshop to solicit their views on emerging technologies expected to impact surgical practice within the next 5 years and/or the importance of different attributes or characteristics of new technologies. Surgeons, regardless of specialty, identified developments designed to enhance existing minimally invasive surgical techniques, such as endoscopic, robotic and image-guided surgery. Several nonsurgical areas, including molecular genetics and nano technology, were also identified. Of the 13 technology attributes discussed, safety or risk, effectiveness and feasibility were rated as most important. Lastly, participating surgeons expressed an interest in becoming further involved in local HTA initiatives. Surgeons, as adopters and users of health technologies, represent an important and accessible information source for identifying emerging technologies for HTA. A more formal, ongoing relationship between the government, HTA and surgeons may help to optimize the use of HTA resources.

The mediation of the Relationship between Organizations and Institutions. The Role of Organizational Culture

Directory of Open Access Journals (Sweden)

M.Şimandan

2013-12-01

Full Text Available This article analyzes the relations between organizations and institutions and their mediation by the factors of organizational culture. After discussing the elements that distinguish organizations from institutions, we will discuss W. R. Scott’s conception regarding the constitutive and functioning structures of the institutions. The following section focuses upon D. C. North’s theory regarding the institutional stability and change, as well as the costs involved by these processes. The last section systematizes a few perspectives regarding the mediation of the relations between organizations and institutions and the role of the organizational culture in this context.

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

OpenAIRE

Lin, Juan; Li, Hanjie; Yang, Min; Ren, Junming; Huang, Zhe; Han, Felicia; Huang, Jian; Ma, Jianhui; Zhang, Duanwu; Zhang, Zhirong; Wu, Jianfeng; Huang, Deli; Qiao, Muzhen; Jin, Guanghui; Wu, Qiao

2013-01-01

Necrotic death of macrophages has long been known to be present in atherosclerotic lesions but has not been studied. We examined the role of receptor interacting protein (RIP) 3, a mediator of necrotic cell death, in atherosclerosis and found that RIP3−/−;Ldlr−/− mice were no different from RIP3+/+;Ldlr−/− mice in early atherosclerosis but had significant reduction in advanced atherosclerotic lesions. Similar results were observed in Apoe−/− background mice. Bone marrow transplantation reveal...

A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis.

Directory of Open Access Journals (Sweden)

Qinghuang Chen

Full Text Available CDKN3 (cyclin-dependent kinase inhibitor 3, a dual specificity protein phosphatase, dephosphorylates cyclin-dependent kinases (CDKs and thus functions as a key negative regulator of cell cycle progression. Deregulation or mutations of CDNK3 have been implicated in various cancers. However, the role of CDKN3 in Bcr-Abl-mediated chronic myelogenous leukemia (CML remains unknown. Here we found that CDKN3 acts as a tumor suppressor in Bcr-Abl-mediated leukemogenesis. Overexpression of CDKN3 sensitized the K562 leukemic cells to imanitib-induced apoptosis and dramatically inhibited K562 xenografted tumor growth in nude mouse model. Ectopic expression of CDKN3 significantly reduced the efficiency of Bcr-Abl-mediated transformation of FDCP1 cells to growth factor independence. In contrast, depletion of CDKN3 expression conferred resistance to imatinib-induced apoptosis in the leukemic cells and accelerated the growth of xenograph leukemia in mice. In addition, we found that CDKN3 mutant (CDKN3-C140S devoid of the phosphatase activity failed to affect the K562 leukemic cell survival and xenografted tumor growth, suggesting that the phosphatase of CDKN3 was required for its tumor suppressor function. Furthermore, we observed that overexpression of CDKN3 reduced the leukemic cell survival by dephosphorylating CDK2, thereby inhibiting CDK2-dependent XIAP expression. Moreover, overexpression of CDKN3 delayed G1/S transition in K562 leukemic cells. Our results highlight the importance of CDKN3 in Bcr-Abl-mediated leukemogenesis, and provide new insights into diagnostics and therapeutics of the leukemia.

The Role of Instructional Technology in Correctional Education.

Science.gov (United States)

Askov, Eunice N.; Turner, Terilyn C.

1990-01-01

Advantages of instructional technology include privacy, individualization, achievement gains, cost effectiveness, flexibility, open-entry/open-exit, and workplace relevance. Disadvantages are constant change, compatibility, cost, expertise and training needed, inappropriateness, and change in teacher and learner roles. (SK)

The Effect of Ethical Leadership Beh avior on Perceived Organizational Climate: Mediating Role of Work Loneliness

Directory of Open Access Journals (Sweden)

Kemal Eroğluer

2015-03-01

Full Text Available In this paper, the effects of ethical leadership behaviors on employees’ perceived organization climate and whether work loneliness plays mediation role in this relationship are researched. A questionnaire has been developed in accordance with study objectives and implemented to 166 employees of a textile company located in Istanbul. Cronbach's Alpha and McDonald's Omega analysis were used to examine the reliability of obtained data and it was seen that the scales are reliable. Structural Equation Modeling (Partial Least Square Method and Sobel tests were used to test the hypothesis. As a result of analysis, it has been seen that ethical leadership has positive and significant effect on employees’ perceived organizational climate and work loneliness plays a partial mediation role in this relationship

The Effects Of Self-Esteem on Academic Motivation: The Mediating Role of Automatic Thoughts

Directory of Open Access Journals (Sweden)

Cemaliye DIREKTOR

2017-06-01

Full Text Available The purpose of the present study is to investigate the mediational role of automatic thoughts on the association between self-esteem and academic motivation. Differences would be analyzed separated according to gender and faculty studied. Participants of the study are 210 undergraduate students (%42.4, 89 women; %57.6, 121 men selected randomly from counselling and intelligence teaching departments of University in Northern Cyprus. All permissions were taken. In order of the aim of self-esteem were assessed using ‘Rosenberg Self-Esteem Questionarie’’. In addition academic motivation was measured by ‘Academic Motivation Scale’ and ‘Automatic Thoughts Inventory’was used in measuring automatic thought levels of the participants. At this study relational screening analysis used, and mediation effect of automatic thoughts were analyzed using Baron and Kenny’s (1986 mediation analysis method. Partial mediation effect of amotivation subscale was proved among self-esteem and negative automatic thought. Evaluating the total effect and direct effect, it is indicated that, the difference is 28% of indirect effect value. Amotivation is related to self esteem and negative automatic thoughts

Psychological maltreatment, emotional and behavioral problems in adolescents: The mediating role of resilience and self-esteem.

Science.gov (United States)

Arslan, Gökmen

2016-02-01

In this study, structural equation modeling was used to examine the mediating role of resilience and self-esteem in the relationships between psychological maltreatment-emotional problems and psychological maltreatment-behavioral problems in adolescents. Participants were 937 adolescents from different high schools in Turkey. The sample included 502 female (53.6%) and 435 male (46.4%) students, 14-19 years old (mean age=16.51, SD=1.15). Results indicated that psychological maltreatment was negatively correlated with resilience and self-esteem, and positively correlated with behavioral problems and emotional problems. Resilience and self-esteem also predicted behavioral problems and emotional problems. Finally, psychological maltreatment predicted emotional and behavioral problems mediated by resilience and self-esteem. Resilience and self-esteem partially mediated the relationship between psychological maltreatment-behavioral and psychological maltreatment-emotional problems in adolescents. Thus, resilience and self-esteem appear to play a protective role in emotional problems and behavioral problems in psychologically maltreated individuals. Implications are discussed and suggestions for psychological counselors and other mental health professionals are presented. Copyright © 2015 Elsevier Ltd. All rights reserved.

Explaining the Discrepancy in the Mediating Role of Attitude in the TAM

Science.gov (United States)

López-Bonilla, Luis Miguel; López-Bonilla, Jesús Manuel

2017-01-01

The debate about the role of attitude in the technology acceptance model (TAM) seems to have re-emerged in two prestigious journals in the field of educational technology. Among the publications on this debate, there are authors in favour of excluding the attitude of TAM, whereas others are in favour of including it. These opinions are derived…

The Role of Educational Technology Professionals as Perceived by Building Administrators

Science.gov (United States)

Murphy, Cheryl A.; Allred, Jonathan B.; Brescia, William F.

2018-01-01

Educational Technology (ETEC) professionals in the United States (US) fill multiple roles in public school systems. While these roles can be classified into broad categories, what remains unclear are the expectations and priorities for the completion of these roles and the tasks associated within each role category. In order for ETEC professionals…

Math anxiety and math performance in children: The mediating roles of working memory and math self-concept.

Science.gov (United States)

Justicia-Galiano, M José; Martín-Puga, M Eva; Linares, Rocío; Pelegrina, Santiago

2017-12-01

Numerous studies, most of them involving adolescents and adults, have evidenced a moderate negative relationship between math anxiety and math performance. There are, however, a limited number of studies that have addressed the mechanisms underlying this relation. This study aimed to investigate the role of two possible mediational mechanisms between math anxiety and math performance. Specifically, we sought to test the simultaneous mediating role of working memory and math self-concept. A total of 167 children aged 8-12 years participated in this study. Children completed a set of questionnaires used to assess math and trait anxiety, math self-concept as well as measures of math fluency and math problem-solving. Teachers were asked to rate each student's math achievement. As measures of working memory, two backward span tasks were administered to the children. A series of multiple mediation analyses were conducted. Results indicated that both mediators (working memory and math self-concept) contributed to explaining the relationship between math anxiety and math achievement. Results suggest that working memory and self-concept could be worth considering when designing interventions aimed at helping students with math anxiety. Longitudinal designs could also be used to better understand the mediational mechanisms that may explain the relationship between math anxiety and math performance. © 2017 The British Psychological Society.

CALL from an Ecological Perspective: How a Teacher Perceives Affordance and Fosters Learner Agency in a Technology-Mediated Language Classroom

Science.gov (United States)

Liu, Qian; Chao, Chin-Chi

2018-01-01

The possibility of exploiting technology for more robust and meaningful learning and teaching has invoked messianic responses from the language education community. Yet to be explored are teachers' pedagogical choices based on the perceived technological affordances as well as interactions between teacher and student agency mediated by these…

Information Technology as the Paradigm High-Speed Management Support Tool: The Uses of Computer Mediated Communication, Virtual Realism, and Telepresence.

Science.gov (United States)

Newby, Gregory B.

Information technologies such as computer mediated communication (CMC), virtual reality, and telepresence can provide the communication flow required by high-speed management techniques that high-technology industries have adopted in response to changes in the climate of competition. Intra-corporate CMC might be used for a variety of purposes…

A cohort study on self-reported role stressors at work and poor sleep: does sense of coherence moderate or mediate the associations?

Science.gov (United States)

Hansen, Åse Marie; Grynderup, Matias Brødsgaard; Rugulies, Reiner; Conway, Paul Maurice; Garde, Anne Helene; Török, Eszter; Mikkelsen, Eva Gemzøe; Persson, Roger; Hogh, Annie

2018-05-01

The aim of the present study was to examine the bidirectional associations between subjective role ambiguity and role conflicts at work, respectively, and self-reported sleep 2 years later. In addition, we also examine whether sense of coherence (SOC) moderate or mediate the association between role stressors and poor sleep and between poor sleep and role stressors. We used questionnaire data collected in 2006 and 2008 from the Workplace Bullying and Harassment cohort. In 2006, 3363 responded to the questionnaire and in 2008 1671 responded. In total, 1569 participants responded in both 2006 and 2008 to the questions on role stressors (in terms of role ambiguity and role conflicts at work) and sleep problems in both 2006 and 2008. Sleep problems were assessed with the awakening index (AWI) and the disturbed sleep index (DSI). Moderation and mediation analyses of the association were estimated using structural equation modelling. We found a prospective association between role stressors and sleep problems [beta values were 0.07 (95% CI 0.03-0.11) and 0.05 (CI 0.01-0.10) for DSI and AWI, respectively] when adjusting for sleep problems at baseline, age, sex, and life style factors (i.e. alcohol, smoking, and leisure time physical activity). SOC moderated the association showing that participants with lower SOC scores who reported higher role ambiguity reported sleep problems to a higher extent than participants with high SOC scores. SOC also mediated the association between role stressors and sleep problems. We also found support for sleep problems at baseline and role stressors 2 years later [DSI 0.04 (CI 0.00-0.08) and 0.15 (CI 0.09-0.21)] for role ambiguity and role conflicts, respectively. Similar results were observed for AWI. Subjective role stressors were prospectively associated with sleep problems. Yet, sleep problems could also prospectively predict subjective role stressors (i.e. reverse causation). The analyses also showed that SOC may be regarded as both

Video game addiction, engagement and symptoms of stress, depression and anxiety: The mediating role of coping.

OpenAIRE

Loton, D.; Borkoles, Erika; Lubman, D.; Polman, Remco C.J.

2016-01-01

A number of studies have reported a co-occurrence between video game addiction and poorer mental health, but few have contextualised this relationship by identifying mediating variables. Further, there remains uncertainty in how to differentiate high engagement from what may be termed addiction in the context of video gaming. This study examined the mediating role of coping between one measure of video game addiction and engagement, and mental health. An international sample of 552 adult part...

The Role of Artificial Intelligence Technologies in Crisis Response

OpenAIRE

Khalil, Khaled M.; Abdel-Aziz, M.; Nazmy, Taymour T.; Salem, Abdel-Badeeh M.

2008-01-01

Crisis response poses many of the most difficult information technology in crisis management. It requires information and communication-intensive efforts, utilized for reducing uncertainty, calculating and comparing costs and benefits, and managing resources in a fashion beyond those regularly available to handle routine problems. In this paper, we explore the benefits of artificial intelligence technologies in crisis response. This paper discusses the role of artificial intelligence technolo...

Core Self-Evaluations as Causes of Satisfaction: The Mediating Role of Seeking Task Complexity

Science.gov (United States)

Srivastava, Abhishek; Locke, Edwin A.; Judge, Timothy A.; Adams, John W.

2010-01-01

This study examined the mediating role of task complexity in the relationship between core self-evaluations (CSE) and satisfaction. In Study 1, eighty three undergraduate business students worked on a strategic decision-making simulation. The simulated environment enabled us to verify the temporal sequence of variables, use an objective measure of…

Care networking: a study of technical mediations in a home telecare service.

Science.gov (United States)

Correa, Gonzalo; Domènech, Miquel

2013-07-22

This article examines the processes of technical mediation within familial care networks based on a study of home telecare targeted at older people. Supported by contributions from the actor-network theory as part of the social psychology of science and technology, these processes of technical mediation are analyzed using a qualitative approach. The data were gathered through six focus groups and four in-depth interviews; the participants in the study included users, relatives and formal carers. Thematic analysis techniques encompassing the information were used, revealing the effects on the patterns of caring relationships. The results show the interplay between presence-absence made possible by the devices; the two-way direction of care between the older people and the artifacts; and the process of sustaining care using the technology. We conclude that care should be seen as a socio-technical network where technology plays an active role in sustaining family relationships.

Safety aid use and social anxiety symptoms: The mediating role of perceived control.

Science.gov (United States)

Korte, Kristina J; Unruh, Amanda S; Oglesby, Mary E; Schmidt, Norman B

2015-08-30

The use of safety aids, cognitive or behavioral strategies used to reduce or cope with anxiety, has emerged as a key construct of interest in anxiety disorders due to their role in the development and maintenance of anxiety symptoms. It has been suggested that individuals with anxiety engage in safety aid use to reduce their anxiety and feel more in control of a situation; however, no studies to date have examined the association between perceived control, that is, perceived level of control over internal events in anxiety provoking situations, and the use of safety aids. The purpose of the present study was to examine the association of perceived control, the use of safety aids, and symptoms of social anxiety. It was predicted that the association between safety aid use and social anxiety symptoms would be mediated by perceived control. This prediction was examined in a large sample of 281 participants. As predicted, perceived control was a significant mediator of the association between the use of safety aids and social anxiety symptoms. This effect remained significant after running a multiple mediation model with distress tolerance added as a competing mediator. Implications for future research are discussed. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Parental Attachment and Adolescents' Perception of School Alienation: The Mediation Role of Self-Esteem and Adjustment.

Science.gov (United States)

Kocayörük, Ercan; Şimşek, Ömer Faruk

2016-01-01

The present study examined the relationship between adolescents' attachment to parents and their feelings of alienation in the school context by considering the mediating role of adjustment and self-esteem. It was proposed that the degree of attachment to one's parents was associated with adjustment and self-esteem, which in turn predicted possible school alienation. A total of 227 students completed self-report measures on parental attachment, adjustment, self-esteem, and alienation from school. Results were consistent with the attachment theory and related literature that posits that (a) secure attachment to parents was associated with adjustment and self-esteem, (b) secure attachment to parents was negatively associated with feelings of school alienation, and (c) adjustment and self-esteem were a crucial mediators between attachment to parents and school alienation. In addition to enhanced adjustment, the self-esteem of adolescents may be an additional factor in reducing alienation at school. The results also supported the mediator role of self-esteem in the relationship between attachment to parents and adjustment. Finally, the relationship between self-esteem and school alienation were shown to be fully mediated by adjustment. The results were discussed in the context of responsibilities of teachers and school counselors, which may provide both students and parents with the skills to improve social functioning in the school context.

Emotional support and well-being of midlife women: role-specific mastery as a mediational mechanism.

Science.gov (United States)

Martire, L M; Stephens, M A; Townsend, A L

1998-09-01

This study examined the relationships among emotional support, mastery, and well-being for 258 women who simultaneously occupied the roles of wife, mother, parent care provider, and employee. Its primary aim was to determine if a greater sense of mastery in each of these 4 roles could explain the relationship between emotional support from the partner or partners in the same role (the husband, children, impaired parent, or work supervisor) and better psychological well-being (less depressive symptomatology and more life satisfaction). Findings revealed that more emotional support from each of the 4 role partners was related to a greater sense of mastery in that same role. Furthermore, for each of the roles of wife, mother, and employee, role-specific mastery was a mediating mechanism in the relationship between support from the role partner or partners and better well-being.

Heterotypic contact reveals a COX-2-mediated suppression of osteoblast differentiation by endothelial cells: A negative modulatory role for prostanoids in VEGF-mediated cell: cell communication?

International Nuclear Information System (INIS)

Clarkin, Claire E.; Garonna, Elena; Pitsillides, Andrew A.; Wheeler-Jones, Caroline P.D.

2008-01-01

In bone, angiogenesis must be initiated appropriately, but limited once remodelling or repair is complete. Our recent findings have supported a role for prostaglandins (PG), known modulators of osteoblast (OB) and endothelial cell (EC) behaviour, in facilitating VEGF-mediated paracrine communication from OBs to 'remotely located' ECs, but the mechanism(s) regulating OB:EC crosstalk when these cells are closely opposed are undefined. In this study we have examined: (i) the effects of exogenous PGE 2 on VEGF-driven events in ECs, and (ii) the role of endogenous COX-2-derived prostanoids in mediating communication between intimately opposed OBs and ECs in direct contact. Exposure of ECs to PGE 2 increased ERK1/2 phosphorylation, COX-2 induction, 6-keto-PGF 1α release and EC proliferation. In contrast, PGE 2 attenuated VEGF 165 -induced VEGFR2/Flk1 phosphorylation, ERK1/2 activation and proliferation of ECs, suggesting that exogenous PGE 2 restricts the actions of VEGF. However, the COX-2-selective inhibitor, NS398, also attenuated VEGF-induced proliferation, implying a distinct role for endogenous COX-2 activity in regulating EC behaviour. To examine the effect of OB:EC proximity and the role of COX-2 products further, we used a confrontational co-culture model. These studies showed that COX-2 blockade with NS398 enhanced EC-dependent increases in OB differentiation, that this effect was reversed by exogenous PGH 2 (immediate COX-2 product), and that exogenous VEGF did not influence EC-dependent OB differentiation under these conditions. Our findings indicate that locally produced prostanoids may serve distinct roles depending on OB:EC proximity and negatively modulate VEGF-mediated changes in EC behaviour when these cells are closely opposed to control angiogenesis during bone (re)modelling

[The mediating role of the interpersonal schemas between parenting styles and psychological symptoms: a schema focused view].

Science.gov (United States)

Soygüt, Gonca; Cakir, Zehra

2009-01-01

The first aim of this study was to examine the relationships between perceived parenting styles and interpersonal schemas. The second purpose was to investigate the mediator role of interpersonal schemas between perceived parenting styles and psychological symptoms. University students (N=94), ages ranging between 17-26, attending to different faculty and classes, have completed Interpersonal Schema Questionnaire, Young Parenting Inventory and Symptom Check List-90. A series of regression analyses revealed that perceived parenting styles have predictive power on a number of interpersonal schemas. Further analyses pointed out that the mediator role of Hostility situation of interpersonal schemas between psychological symptoms and normative, belittling/criticizing, pessimistic/worried parenting styles on the mother forms (Sobel z= 1.94-2.08, p parenting styles (Sobel z= 2.20-2.86, p parenting styles on interpersonal schemas. Moreover, the mediator role of interpersonal schemas between perceived parenting styles and psychological symptoms was also observed. Excluding pessimistic/anxious parenting styles, perceived parenting styles of mothers and fathers differed in their relation to psychological symptoms. In overall evaluation, we believe that, although schemas and parental styles have some universalities in relation to their impacts on psychological health, further research is necessary to address their implications and possible paternal differences in our collectivistic cultural context.

Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease.

Science.gov (United States)

Kajiya, Mikihito; Giro, Gabriela; Taubman, Martin A; Han, Xiaozhe; Mayer, Marcia P A; Kawai, Toshihisa

2010-11-08

Accumulated lines of evidence suggest that hyperimmune responses to periodontal bacteria result in the destruction of periodontal connective tissue and alveolar bone. The etiological roles of periodontal bacteria in the onset and progression of periodontal disease (PD) are well documented. However, the mechanism underlying the engagement of periodontal bacteria in RANKL-mediated alveolar bone resorption remains unclear. Therefore, this review article addresses three critical subjects. First, we discuss earlier studies of immune intervention, ultimately leading to the identification of bacteria-reactive lymphocytes as the cellular source of osteoclast-induction factor lymphokine (now called RANKL) in the context of periodontal bone resorption. Next, we consider (1) the effects of periodontal bacteria on RANKL production from a variety of adaptive immune effector cells, as well as fibroblasts, in inflamed periodontal tissue and (2) the bifunctional roles (upregulation vs. downregulation) of LPS produced from periodontal bacteria in a RANKL-induced osteoclast-signal pathway. Future studies in these two areas could lead to new therapeutic approaches for the management of PD by down-modulating RANKL production and/or RANKL-mediated osteoclastogenesis in the context of host immune responses against periodontal pathogenic bacteria.

Value congruence and depressive symptoms among critical care clinicians: The mediating role of moral distress.

Science.gov (United States)

Lamiani, Giulia; Dordoni, Paola; Argentero, Piergiorgio

2018-02-01

Clinicians working in intensive care units are often exposed to several job stressors that can negatively affect their mental health. Literature has acknowledged the role of value congruence and job control in determining clinicians' psychological well-being and depressive symptoms. However, potential mediators of this association have been scarcely examined. This study aimed to test the mediating role of moral distress in the relationship between value congruence and job control, on the one hand, and depression, on the other hand. A cross-sectional study involving physicians, nurses, and residents working in 7 intensive care units in the north of Italy was conducted. Clinicians were administered in the Italian Moral Distress Scale-Revised, the value and control subscales of the Areas of Worklife Scale, and the Beck Depression Inventory II. Structural equation modeling was used to test the mediation model. Analysis on 170 questionnaires (response rate 72%) found no relations between job control and moral distress. A total indirect effect of value congruence on depression through moral distress (β = -.12; p = .02) was found. Moral distress contributes to the development of depressive symptoms among critical care clinicians who perceive a value incongruence with their organization and therefore should be addressed. Copyright © 2017 John Wiley & Sons, Ltd.

Depression and medication adherence among older Korean patients with hypertension: Mediating role of self-efficacy.

Science.gov (United States)

Son, Youn-Jung; Won, Mi Hwa

2017-06-01

Many studies have reported the negative effects of depression on adherence to antihypertensive medication. However, little is known about the mechanism underlying this relationship in elderly patients with hypertension. The aim of this cross-sectional study is to examine the mediating role of self-efficacy in the relationship between depression and medication adherence among older patients with hypertension. The data were collected from October to December 2014. A total of 255 older patients with hypertension were assessed using the Geriatric Depression Scale, the Self-efficacy for Appropriate Medication Use Scale, and the Morisky Medication Adherence Scale. Hierarchical linear regression analysis and the Sobel test were used to examine the mediating role of self-efficacy in the relationship between depression and medication adherence. Depression and self-efficacy were statistically significant predictors of medication adherence in older patients with hypertension. Self-efficacy partially mediated the relationship between depression and medication adherence. Interventions targeting self-efficacy could increase the confidence of patients in their ability to actively take their medicines. Moreover, health care providers should be aware of the importance of early detection of depression in older patients with hypertension. Future studies with longitudinal data are warranted to clarify the multidirectional relationships between depression, self-efficacy, and medication adherence. © 2017 John Wiley & Sons Australia, Ltd.

The evolving role of information technology in internal auditing

OpenAIRE

2015-01-01

M.Com. (Computer Auditing) Modern organizations are increasingly dependent on information technology (IT) for various reasons: to enhance their operational efficiency, reduce costs or even attain a competitive advantage. The role of information technology in the organization continues to evolve and this has an impact for the internal audit functions that serve these organizations. The study investigated whether the King III report, ISACA standards and IIA standards assist the internal audi...

How does emotion influence different creative performances? The mediating role of cognitive flexibility.

Science.gov (United States)

Lin, Wei-Lun; Tsai, Ping-Hsun; Lin, Hung-Yu; Chen, Hsueh-Chih

2014-01-01

Cognitive flexibility is proposed to be one of the factors underlying how positive emotions can improve creativity. However, previous works have seldom set up or empirically measured an independent index to demonstrate its mediating effect, nor have they investigated its mediating role on different types of creative performances, which involve distinct processes. In this study, 120 participants were randomly assigned to positive, neutral or negative affect conditions. Their levels of cognitive flexibility were then measured by a switch task. Finally, their creative performances were calibrated by either an open-ended divergent thinking test or a closed-ended insight problem-solving task. The results showed that positive emotional states could reduce switch costs and enhance both types of creative performances. However, cognitive flexibility exhibited a full mediating effect only on the relationship between positive emotion and insight problem solving, but not between positive emotion and divergent thinking. Divergent thinking was instead more associated with arousal level. These results suggest that emotions might influence different creative performances through distinct mechanisms.

School motivation and high school dropout: the mediating role of educational expectation.

Science.gov (United States)

Fan, Weihua; Wolters, Christopher A

2014-03-01

A good deal of evidence indicates that students' motivational beliefs and attitudes play a critical role in their academic success. Research studies on how motivational factors may help determine whether students remain in high school or drop out, however, are relatively few. More specifically, there is a lack of research examining the dynamics of whether students' motivational beliefs from earlier in high school might be used to predict their status as a dropout in their final year. The aim of the present study was to examine the mediating role of students' educational expectations in linking students' school motivation to their dropout status by utilizing a nationally representative dataset. The present study used data from the Educational Longitudinal Study of 2002 (ELS: 2002). The final sample consisted of 16,194 students, with approximately 54% White, 13% Black, 16% Hispanic, and 10% Asian students, and the rest were Native American, Hawaiian, multiracial, or of other races. Structural equation modelling was employed to conduct the mediational analysis. The results of the present study demonstrated that the relationships between student ability beliefs in math and English and student behaviour of dropping out were fully mediated by students' educational expectations. The results also revealed that student intrinsic value in math and English had significant indirect relations with student behaviour of leaving school through students' educational expectations. The results of this study suggest that explanations for student dropout status that rely solely on students' social background and school behaviours without considering their motivation are incomplete. The study expands the extant research by showing possible pathways that motivate students to persist in high school. These pathways are specifically rooted in students' ability beliefs and intrinsic interest in learning through their relationships with students' expectations for their education. © 2012 The

Process is king: Evaluating the performance of technology-mediated learning in vocational software training

OpenAIRE

Söllner, Matthias; Bitzer, Philipp; Janson, Andreas; Leimeister, Jan Marco

2017-01-01

Technology-mediated learning (TML) is a major trend in education, since it allows to integrate the strengths of traditional- and IT-based learning activities. However, TML providers still struggle in identifying areas for improvement in their TML offerings. One reason for their struggles is inconsistencies in the literature regarding drivers of TML performance. Prior research suggests that these inconsistencies in TML literature might stem from neglecting the importance of considering the pro...

Leadership and change commitment in the life insurance service context in Taiwan: the mediating-moderating role of job satisfaction.

Science.gov (United States)

Yang, Yi-Feng

2011-06-01

The effects of transformational leadership and satisfaction were studied along with their interconnected effects (mediation and moderation) on commitment to change in the life insurance industry in two samples, sales managers and salespersons. A multiple mediated-moderated regression approach showed mediation and moderation to have statistically significant main effects on change commitment. Transformational leadership and satisfaction made a more important contribution to change commitment while job satisfaction had a mediating and moderating role that could enhance the relationships between leadership and change commitment. This information is of importance in building successful change commitment associations with customers.

Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease

OpenAIRE

Mikihito Kajiya; Gabriela Giro; Martin A. Taubman; Xiaozhe Han; Marcia P.A. Mayer; Toshihisa Kawai

2010-01-01

Accumulated lines of evidence suggest that hyperimmune responses to periodontal bacteria result in the destruction of periodontal connective tissue and alveolar bone. The etiological roles of periodontal bacteria in the onset and progression of periodontal disease (PD) are well documented. However, the mechanism underlying the engagement of periodontal bacteria in RANKL-mediated alveolar bone resorption remains unclear. Therefore, this review article addresses three critical subjects. First, ...

The national laboratory business role in energy technology research and development. Panel Discussion

International Nuclear Information System (INIS)

Sackett, John; Sullivan, Charles J.; Aumeier, Steve; Sanders, Tom; Johnson, Shane; Bennett, Ralph

2001-01-01

Full text of publication follows: Energy issues will play a pivotal role in the economic and political future of the United States. For reasons of both available supply and environmental concerns, development and deployment of new energy technologies is critical. Nuclear technology is important, but economic, political, and technical challenges must be overcome if it is to play a significant role. This session will address business opportunities for national laboratories to contribute to the development and implementation of a national energy strategy, concentrating on the role of nuclear technology. Panelists have been selected from the national laboratories, the U.S. Department of Energy, and state regulators. (authors)

Social cues-customer behavior relationship : the mediating role of emotions and cognition

OpenAIRE

Nusairat, NM; Akhorshaideh, AHO; Rashid, T; Sahadev, S; Rembielak, G

2017-01-01

This paper investigates the effect of social cues in a mall’s shopping environment on customer behavior. Two competing mediation scenarios are assessed: emotion-cognition and cognition-emotion in a stimulus-organism-response (SOR)-based framework. Although the role of social cues in driving customer behavior in shopping contexts is largely addressed in the extant literature, the mechanism of the effect is still under-researched area and this study is an attempt to fill this gap.\\ud The concep...

Situated technology in reproductive health care: Do we need a new theory of the subject to promote person-centred care?

Science.gov (United States)

Stankovic, Biljana

2017-01-01

Going through reproductive experiences (especially pregnancy and childbirth) in contemporary Western societies almost inevitably involves interaction with medical practitioners and various medical technologies in institutional context. This has important consequences for women as embodied subjects. A critical appraisal of these consequences-coming dominantly from feminist scholarship-relied on a problematic theory of both technology and the subject, which are in contemporary approaches no longer considered as given, coherent and well individualized wholes, but as complex constellations that are locally situated and that can only be described empirically. In this study, we will be relying on the developments in phenomenological theory to reconceptualize women as technologically mediated embodied subjects and on the new paradigms in philosophy of technology and STS to reconstruct medical technology as situated-with the aim of reconceptualizing their relationship and exploring different possibilities for the mediating role of medical technology. It will be argued that technologization of female reproductive processes and alienating consequences for women are not necessary or directly interrelated. The role of technology varies from case to case and depends mainly on the nontechnological and relational aspects of institutional context, in which medical practitioners play a decisive role. © 2016 John Wiley & Sons Ltd.

Relationships between the Advertising Appeal and Behavioral Intention: The Mediating role of the Attitude towards Advertising Appeal

OpenAIRE

Raza Syed Hassan; Abu Bakar Hassan; Mohamad Bahtiar

2017-01-01

The link between the advertising appeal, attitude and behavioral intention is dynamic in nature, however, little research has been pursued towards explaining the mediating role of attitude towards the advertising in link of the advertising appeal with the behavioral intention. Researchers have identified the importance of the attitude in the connection of the advertising appeal within the framework of the (TPB) which remains unaddressed in the explicating the mediation of the attitude in rela...

Trauma exposure and the mediating role of posttraumatic stress on somatic symptoms in civilian war victims.

Science.gov (United States)

Morina, Naser; Schnyder, Ulrich; Klaghofer, Richard; Müller, Julia; Martin-Soelch, Chantal

2018-04-10

It has been well documented that the exposure to war has a negative effect on the psychological health of civilian. However, little is known on the impact of war exposure on the physical health of the civilian population. In addition, the link between trauma exposure and somatic symptoms remain poorly understood. This cross-sectional study examined levels of somatic symptoms in the aftermath of war, and the mediating role of posttraumatic stress symptoms in the relationship between trauma exposure and somatic symptoms. Civilian war survivors (N = 142) from Kosovo were assessed for potentially traumatic events, posttraumatic stress symptoms, and somatic symptoms. Data were analyzed using mediation analyses. Posttraumatic stress disorder (PTSD) symptoms were categorized based on King's four factor model (Psychol Assessment. 10: 90-96, 1998). Participants reported on average more than 5 types of traumatic exposure. The cut-off indicative for PTSD was exceeded by 26.1% of participants. Symptom levels of PTSD were associated with somatic symptoms. The relationship between trauma exposure and somatic symptoms was partly mediated by the active avoidance and hyperarousal symptom clusters of PTSD. Active avoidance and hyperarousal symptoms seem to play a key role in traumatized people suffering from somatic symptoms.

Justifying gender discrimination in the workplace: The mediating role of motherhood myths.

Science.gov (United States)

Verniers, Catherine; Vala, Jorge

2018-01-01

The issue of gender equality in employment has given rise to numerous policies in advanced industrial countries, all aimed at tackling gender discrimination regarding recruitment, salary and promotion. Yet gender inequalities in the workplace persist. The purpose of this research is to document the psychosocial process involved in the persistence of gender discrimination against working women. Drawing on the literature on the justification of discrimination, we hypothesized that the myths according to which women's work threatens children and family life mediates the relationship between sexism and opposition to a mother's career. We tested this hypothesis using the Family and Changing Gender Roles module of the International Social Survey Programme. The dataset contained data collected in 1994 and 2012 from 51632 respondents from 18 countries. Structural equation modellings confirmed the hypothesised mediation. Overall, the findings shed light on how motherhood myths justify the gender structure in countries promoting gender equality.

Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis.

Science.gov (United States)

Wang, Weiye; Xu, Suowen; Yin, Meimei; Jin, Zheng Gen

2015-02-15

Growth factors and their downstream receptor tyrosine kinases (RTKs) mediate a number of biological processes controlling cell function. Adaptor (docking) proteins, which consist exclusively of domains and motifs that mediate molecular interactions, link receptor activation to downstream effectors. Recent studies have revealed that Grb2-associated-binders (Gab) family members (including Gab1, Gab2, and Gab3), when phosphorylated on tyrosine residues, provide binding sites for multiple effector proteins, such as Src homology-2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) and phosphatidylinositol 3-kinase (PI3K) regulatory subunit p85, thereby playing important roles in transducing RTKs-mediated signals into pathways with diversified biological functions. Here, we provide an up-to-date overview on the domain structure and biological functions of Gab1, the most intensively studied Gab family protein, in growth factor signaling and biological functions, with a special focus on angiogenesis. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Academic Stress and Self-Regulation among University Students in Malaysia: Mediator Role of Mindfulness.

Science.gov (United States)

Hj Ramli, Nur Hamizah; Alavi, Masoumeh; Mehrinezhad, Seyed Abolghasem; Ahmadi, Atefeh

2018-01-15

Academic stress is the most common emotional or mental state that students experience during their studies. Stress is a result of a wide range of issues, including test and exam burden, a demanding course, a different educational system, and thinking about future plans upon graduation. A sizeable body of literature in stress management research has found that self-regulation and being mindful will help students to cope up with the stress and dodge long-term negative consequences, such as substance abuse. The present study aims to investigate the influence of academic stress, self-regulation, and mindfulness among undergraduate students in Klang Valley, Malaysia, and to identify mindfulness as the mediator between academic stress and self-regulation. For this study, a total of 384 undergraduate students in Klang Valley, Malaysia were recruited. Using Correlational analysis, results revealed that there was a significant relationship between academic stress, self-regulation, and mindfulness. However, using SPSS mediational analysis, mindfulness did not prove the mediator role in the study.

IRBIT plays an important role in NHE3-mediated pHi regulation in HSG cells.

Science.gov (United States)

Tran, Tien Manh; Park, Moon-Yong; Lee, Jiyeon; Bae, Jun-Seok; Hwang, Sung-Min; Choi, Se-Young; Mikoshiba, Katsuhiko; Park, Kyungpyo

2013-07-19

Expression of inositol-1,4,5-trisphosphate (IP3) receptor-binding protein (IRBIT) has been reported in epithelial cells. However, its role in pHi regulation is not well understood. In this study, we investigated the role of IRBIT in pHi regulation, mediated by Na(+)/H(+) exchangers (NHEs), in salivary glands. We measured pHi recovery from cell acidification in BCECF-loaded salivary HSG cells. Western blot and co-immunoprecipitation (CO-IP) assays were also performed, showing that NHE1, 2 and 3 are expressed, and IRBIT binds to NHE3. HOE642, a specific NHE1 blocker, inhibited pHi recovery, but 40% pH(i) recovery was still observed even at the highest concentration of HOE642. Furthermore, pretreatment of the cells with siIRBIT significantly inhibited pHi recovery, indicating that NHE3 potentially plays a role in pHi recovery as well. The amount of membrane-localized NHE3 and its interaction with IRBIT are also significantly increased by cell acidification. In addition, we found that Ste20p-related proline alanine-rich kinase (SPAK) reverses the effect of IRBIT on membrane NHE3 translocation. Taken together, we conclude that IRBIT plays an important role in pHi regulation, mediated by NHE3, and further regulated by SPAK. Copyright © 2013 Elsevier Inc. All rights reserved.

Development of the Information Technology Sector in India: the Role of Government

Directory of Open Access Journals (Sweden)

Inna S. Ashmyanskaya

2014-01-01

Full Text Available In the article the author analyses the role of government in developing the information technology sector in India, specifically its influence on the three factors that determine the development of the information technology sector: human resources, launch capital and infrastructure. By developing these factors, the Indian government has succeeded in prompt formation and promotion of the information technology sector. The development of human capital is mainly realized by developing public education programs. The establishment of close ties with the Indian diaspora played a crucial role. The diaspora acted as a link for transmission to India of expertise, investment and knowledge. The availability of start-up capital, especially venture capital, is another essential component for the success of the national information technology sector. The conditions created by a government for the development of the institution of venture investment in the country will be of fundamental importance. Thanks to the measures taken by the government of India, venture capital investment has become the main form of financing for start-ups in the information technology sector in India. Developed infrastructure is also an important factor in the development of the information technology sector. In India, a developing country with a vast territory, there was a problem of infrastructure development, and software technology parks became a solution to this problem for companies in the information technology sector. Over the past 20 years, software technology parks in India has evolved so that industrial parks created almost 50% of the total exports of the IT sector in India. The demonstrated state policy can be characterized as the model of state technological entrepreneurship according to which the Indian government played the roles of regulator, producer and promoter in the information technology sector and continues to do so until the present day.

The Effect of Automatic Thoughts on Hopelessness: Role of Self-Esteem as a Mediator

Science.gov (United States)

Cakar, Firdevs Savi

2014-01-01

The purpose of this study is to test a theoretical model concerning the role of self-esteem as a mediator between university students' automatic thoughts and their levels of hopelessness. The participants consisted of 338 students (197 females (58.3%) and 141 males (41.7%) from various departments at the Celal Bayar University. The research data…

Parental Interpersonal Sensitivity and Youth Social Problems: A Mediational Role for Child Emotion Dysregulation

Science.gov (United States)

Suveg, Cynthia; Jacob, Marni L.; Payne, Mary

2010-01-01

We examined the relations between parental interpersonal sensitivity and youth social problems and explored the mediational role of child emotion dysregulation. Mothers (N = 42; M age = 39.38) and fathers (N = 41; M age = 39.38) of youth aged 7-12 (N = 42; M age = 9.12) completed measures of their own interpersonal sensitivity and reported on…

Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation

Directory of Open Access Journals (Sweden)

Yosuke eIsobe

2012-08-01

Full Text Available Acute inflammation and its resolution are essential processes for tissue protection and homeostasis. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programs that enable inflamed tissues to return to homeostasis. The mechanisms by which acute inflammation is resolved are of interest, and research in recent years has uncovered new endogenous anti-inflammatory and pro-resolving lipid mediators (i.e. lipoxins, resolvins, protectin, and maresin generated from polyunsaturated fatty acids (PUFAs. This review presents new insights into the cellular and molecular mechanisms of inflammatory resolution, especially the roles of eosinophils, and a series of omega-3 PUFA derived anti-inflammatory lipid mediators that they generate.

Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

Directory of Open Access Journals (Sweden)

Yanyan Yang

2014-01-01

Full Text Available Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs are proline-directed serine and threonine protein kinases that regulate many physiological and pathophysiological cell responses. p38 MAPKs are key MAPKs involved in the production of inflammatory mediators, including tumor necrosis factor-α (TNF-α and cyclooxygenase-2 (COX-2. p38 MAPK signaling plays an essential role in regulating cellular processes, especially inflammation. In this paper, we summarize the characteristics of p38 signaling in macrophage-mediated inflammation. In addition, we discuss the potential of using inhibitors targeting p38 expression in macrophages to treat inflammatory diseases.

The Role of Cgrp-Receptor Component Protein (Rcp in Cgrp-Mediated Signal Transduction

Directory of Open Access Journals (Sweden)

M. A. Prado

2001-01-01

Full Text Available The calcitonin gene-related peptide (CGRP-receptor component protein (RCP is a 17-kDa intracellular peripheral membrane protein required for signal transduction at CGRP receptors. To determine the role of RCP in CGRP-mediated signal transduction, RCP was depleted from NIH3T3 cells using antisense strategy. Loss of RCP protein correlated with loss of cAMP production by CGRP in the antisense cells. In contrast, loss of RCP had no effect on CGRP-mediated binding; therefore RCP is not acting as a chaperone for the CGRP receptor. Instead, RCP is a novel signal transduction molecule that couples the CGRP receptor to the cellular signal transduction machinery. RCP thus represents a prototype for a new class of signal transduction proteins that are required for regulation of G protein-coupled receptors.

The role of mediation in resolving contract disputes

OpenAIRE

Christian, Michael C

1997-01-01

Approved for public release; distribution is unlimited Mediation has emerged as a preferred ADR method among commercial organizations involved in contract disputes. However, its use by the Navy has been rare. Mediation has shown to provide benefits to its commercial users such as: improved business relations, time and cost savings, flexibility and adaptability and superior control over outcomes. This thesis provides information on mediation and examines the differences and similarities bet...

Care Networking: A Study of Technical Mediations in a Home Telecare Service

Science.gov (United States)

Correa, Gonzalo; Domènech, Miquel

2013-01-01

This article examines the processes of technical mediation within familial care networks based on a study of home telecare targeted at older people. Supported by contributions from the actor—network theory as part of the social psychology of science and technology, these processes of technical mediation are analyzed using a qualitative approach. The data were gathered through six focus groups and four in-depth interviews; the participants in the study included users, relatives and formal carers. Thematic analysis techniques encompassing the information were used, revealing the effects on the patterns of caring relationships. The results show the interplay between presence-absence made possible by the devices; the two-way direction of care between the older people and the artifacts; and the process of sustaining care using the technology. We conclude that care should be seen as a socio-technical network where technology plays an active role in sustaining family relationships. PMID:23880730

Workaholism, work engagement and work-home outcomes: exploring the mediating role of positive and negative emotions.

Science.gov (United States)

Clark, Malissa A; Michel, Jesse S; Stevens, Gregory W; Howell, Julia W; Scruggs, Ross S

2014-10-01

This study examines the mechanisms through which workaholism and work engagement impact work-home conflict and enrichment, respectively. Specifically, we examine the mediating role of positive and negative emotions (e.g. joviality and guilt) in the relationship between workaholism, work engagement and work-home outcomes. Results, based on a sample of 340 working adults participating in a two-wave study, indicate that negative emotions-particularly anxiety, anger and disappointment-mediate the relationship between workaholism and work-home conflict and positive emotions-particularly joviality and self-assurance-mediate the relationship between work engagement and work-home enrichment. These results provide further evidence that workaholism and work engagement are related to distinct sets of emotional variables and disparate work and home outcomes. Copyright © 2013 John Wiley & Sons, Ltd.

Planning Abilities in Bilingual and Monolingual Children: Role of Verbal Mediation

Science.gov (United States)

Gangopadhyay, Ishanti; McDonald, Margarethe; Ellis Weismer, Susan; Kaushanskaya, Margarita

2018-01-01

We examined the role of verbal mediation in planning performance of English–Spanish-speaking bilingual children and monolingual English-speaking children, between the ages of 9 and 12 years. To measure planning, children were administered the Tower of London (ToL) task. In a dual-task paradigm, children completed ToL problems under three conditions: with no secondary task (baseline), with articulatory suppression, and with non-verbal motor suppression. Analyses revealed generally shorter planning times for bilinguals than monolinguals but both groups performed similarly on number of moves and execution times. Additionally, bilingual children were more efficient at planning throughout the duration of the task while monolingual children showed significant gains with more practice. Children’s planning times under articulatory suppression were significantly shorter than under motor suppression as well as the baseline condition, and there was no difference in planning times between monolingual and bilingual children during articulatory suppression. These results demonstrate that bilingualism influences performance on a complex EF measure like planning, and that these effects are not related to verbal mediation. PMID:29593620

Planning Abilities in Bilingual and Monolingual Children: Role of Verbal Mediation.

Science.gov (United States)

Gangopadhyay, Ishanti; McDonald, Margarethe; Ellis Weismer, Susan; Kaushanskaya, Margarita

2018-01-01

We examined the role of verbal mediation in planning performance of English-Spanish-speaking bilingual children and monolingual English-speaking children, between the ages of 9 and 12 years. To measure planning, children were administered the Tower of London (ToL) task. In a dual-task paradigm, children completed ToL problems under three conditions: with no secondary task (baseline), with articulatory suppression, and with non-verbal motor suppression. Analyses revealed generally shorter planning times for bilinguals than monolinguals but both groups performed similarly on number of moves and execution times. Additionally, bilingual children were more efficient at planning throughout the duration of the task while monolingual children showed significant gains with more practice. Children's planning times under articulatory suppression were significantly shorter than under motor suppression as well as the baseline condition, and there was no difference in planning times between monolingual and bilingual children during articulatory suppression. These results demonstrate that bilingualism influences performance on a complex EF measure like planning, and that these effects are not related to verbal mediation.

Trauma and psychosis: The mediating role of self-concept clarity and dissociation.

Science.gov (United States)

Evans, Gavin John; Reid, Graeme; Preston, Phil; Palmier-Claus, Jasper; Sellwood, William

2015-08-30

Childhood trauma (CT) and psychosis may be associated. Drawing on the dissociation and social psychological literature, the current study examined the mediating role of structural aspects of self in explaining the relationship between childhood trauma and psychosis. Twenty-nine individuals with psychosis were compared with 31 healthy volunteers regarding childhood trauma, dissociation and self-concept clarity (SCC). High rates of maltreatment were found in the psychosis sample. Additionally, clinical participants reported more dissociation and less self-concept clarity. Mediational analyses were carried out on pooled data from across both clinical and non-clinical samples. These suggested that the influence of physical neglect in increasing the likelihood of experiencing psychosis was explicable through the effects of increased dissociation. Self-concept clarity mediated the relationship between psychosis and total childhood trauma, emotional abuse, physical abuse, emotional and physical neglect. Furthermore, dissociation and self-concept clarity were strongly correlated providing evidence that they may form a unitary underlying concept of 'self-concept integration'. The study provides further evidence of the link between childhood trauma and psychosis. Self-concept integration may be adversely affected by negative childhood experiences, which increases psychosis risk. Methodological limitations, clinical implications and suggestions for future research are considered. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The Mediating Role of Conscientiousness Personality Characteristic in Relationship between Attitude toward Addiction and Academic Achievement

Directory of Open Access Journals (Sweden)

S Rezaei

2014-12-01

Full Text Available Objective: This study is aimed at examining the mediating role of personality trait of conscientiousness in the relationship between attitudes towards addiction (which is considered to be a barrier to educational achievement and students’ academic performance. Method: As a cross sectional study lying within the range of descriptive studies, 106 students of Guilan University of medical sciences in 2010-2011 were randomly selected as the study sample and responded to the items of subscale conscientiousnessof NEO Personality Inventory and attitude measurement questionnaire toward addiction. Recent acquired total averages of students were considered as academic performance. Findings: In the first step, the academic performance regression was significant aboard tendency towards addiction. In the second step, however, with entry of conscientiousness as a mediator variable , there was observed a significant decrease in the β coefficient of attitude toward addiction and lost its significance. In other words, the mediator variable, consciousness, plays a mediating part in the relationship between tendency to addiction and educational performance. In general, these two variables could moderately explain 12% of the variance in academic performance to make the adjustment. Conclusion: Conscientious people enjoy higher achievement and lower degree often tendency toward addiction due to such factors as self-regulation, perseverance, and resistance against harmful impulses. Therefore,the personality trait of conscientiousness can counteract the detrimental effect of attitude toward addiction on academic performance through performing a protective role.

Psychological Capital, Career Identity and Graduate Employability in Uganda: The Mediating Role of Social Capital

Science.gov (United States)

Ngoma, Muhammad; Dithan Ntale, Peter

2016-01-01

This paper seeks to evaluate the relationship between psychological capital, career identity, social capital and graduate employability. We also seek to evaluate the mediating role of social capital on the relationships between psychological capital, career identity and graduate employability in Uganda. A population of 480 unemployed young people…

Effects of Teachers' Organizational Justice Perceptions on Intention to Quit: Mediation Role of Organizational Identification

Science.gov (United States)

Basar, Ufuk; Sigri, Ünsal

2015-01-01

This research aims to discover the effects of teachers' organizational justice perceptions on intention to quit as well as the mediation role of teachers' organizational identification in this process. Interactions between research variables were measured using structural equation models. The sample used comprised teachers working at primary and…

Parental Acceptance/Involvement, Self-Esteem and Academic Achievement: The Role of Hope as a Mediator

Science.gov (United States)

Aydin, Betül; Sari, Serkan Volkan; Sahin, Mustafa

2014-01-01

In this study, examining the relationship of parental acceptance/involvement to self-esteem, hope and academic achievement besides, mediating role of hope on the relationship between perception of parental acceptance/involvement, self esteem and academic achievement were aimed. The study was carried out with 297 students from different…

The mediating role of stigmatization in the mental health of adolescent victims of sexual violence in Eastern Congo.

Science.gov (United States)

Verelst, A; De Schryver, M; De Haene, L; Broekaert, E; Derluyn, I

2014-07-01

This study aims to explore the factors that explain the mental sequelae of war-related sexual violence and focuses in particular on the role of stigmatization. Drawing on a large-scale quantitative survey undertaken in the war-affected region of eastern Democratic Republic of the Congo, we analyze how stigmatization mediates the mental health impact of sexual violence on adolescent girls who were victims of rape. Twenty-two secondary schools were randomly selected out of a stratified sample in Bunia, Eastern Congo. In a cross-sectional, population-based survey, 1,305 school-going adolescent girls aged 11-23 completed self-report measures assessing war-related traumatic events, experiences of sexual violence, stigmatization, and mental health symptoms. Of the 1,305 participants, 38.2% (n=499) reported experiences of sexual violence. Victims of sexual violence reported more war-related traumatic events and more stigmatization experiences. Several hierarchical regression analyses examined the mediating impact of stigmatization on the relationship between sexual violence and mental health outcomes, thereby controlling for sociodemographics (age, parental availability, and socioeconomic status) and war-related traumatic exposure. Our findings show that this stigmatization largely explains the mental health impact of sexual violence, in particular, on adolescent girls' reported symptoms of depression (full mediation) and posttraumatic stress (avoidance and total PTSD: full mediation; hyperarousal: partial (40%) mediation). No evidence of mediation by stigmatization was found for symptoms of anxiety and intrusion. Stigmatization plays thus an important role in shaping the mental sequelae of sexual violence, a finding with major consequences for clinical practice. Copyright © 2014 Elsevier Ltd. All rights reserved.

Designing business rules for mediation : a process towards agent-mediated business coordination

NARCIS (Netherlands)

Zhao, Z.; Dignum, M.V.; Dignum, F.P.M.

2008-01-01

Business process integration is a very active research area, in which mediation is one of the fundamental architectural choices. Mediators have difficulties to design mediation services that meet the requirements of the different stakeholders. Business rules play an important role in the

The mediating role of psychological capital on the association between occupational stress and job burnout among bank employees in China.

Science.gov (United States)

Li, Xirui; Kan, Dan; Liu, Li; Shi, Meng; Wang, Yang; Yang, Xiaoshi; Wang, Jiana; Wang, Lie; Wu, Hui

2015-03-10

Although job burnout is common among bank employees, few studies have explored positive resources for combating burnout in this population. This study aims to explore the relationship between occupational stress and job burnout among Chinese bank employees, and particularly the mediating role of psychological capital. A cross-sectional study was conducted in Liaoning, China, during June to August of 2013. A questionnaire that included the effort-reward imbalance scale, the Psychological Capital Questionnaire and the Maslach Burnout Inventory-General Survey, as well as demographic and working factors, was distributed to 1739 employees of state-owned banks. This yielded 1239 effective respondents (467 men, 772 women). Asymptotic and resampling strategies explored the mediating role of psychological capital in the relationship between occupational stress and job burnout. Both extrinsic effort and overcommitment were positively associated with emotional exhaustion and depersonalisation. Meanwhile, reward was negatively associated with emotional exhaustion and depersonalisation, but positively associated with personal accomplishment. There was a gender difference in the mediating role of Psychological capital on the occupational stress-job burnout. In male bank employees, Psychological capital mediated the relationships of extrinsic effort and reward with emotional exhaustion and depersonalization; in female bank employees, it partially mediated the relationships of extrinsic effort, reward and overcommitment with emotional exhaustion and depersonalisation, as well as the relationship between reward and personal accomplishment. Psychological capital was generally a mediator between occupational stress and job burnout among Chinese bank employees. Psychological capital may be a potential positive resource in reducing the negative effects of occupational stress on job burnout and relieving job burnout among bank employees, especially female bank employees.

The Mediating Role of Psychological Capital on the Association between Occupational Stress and Job Burnout among Bank Employees in China

Directory of Open Access Journals (Sweden)

Xirui Li

2015-03-01

Full Text Available Although job burnout is common among bank employees, few studies have explored positive resources for combating burnout in this population. This study aims to explore the relationship between occupational stress and job burnout among Chinese bank employees, and particularly the mediating role of psychological capital. A cross-sectional study was conducted in Liaoning, China, during June to August of 2013. A questionnaire that included the effort-reward imbalance scale, the Psychological Capital Questionnaire and the Maslach Burnout Inventory-General Survey, as well as demographic and working factors, was distributed to 1739 employees of state-owned banks. This yielded 1239 effective respondents (467 men, 772 women. Asymptotic and resampling strategies explored the mediating role of psychological capital in the relationship between occupational stress and job burnout. Both extrinsic effort and overcommitment were positively associated with emotional exhaustion and depersonalisation. Meanwhile, reward was negatively associated with emotional exhaustion and depersonalisation, but positively associated with personal accomplishment. There was a gender difference in the mediating role of Psychological capital on the occupational stress-job burnout. In male bank employees, Psychological capital mediated the relationships of extrinsic effort and reward with emotional exhaustion and depersonalization; in female bank employees, it partially mediated the relationships of extrinsic effort, reward and overcommitment with emotional exhaustion and depersonalisation, as well as the relationship between reward and personal accomplishment. Psychological capital was generally a mediator between occupational stress and job burnout among Chinese bank employees. Psychological capital may be a potential positive resource in reducing the negative effects of occupational stress on job burnout and relieving job burnout among bank employees, especially female bank

Mediation Analysis Using the Hierarchical Multiple Regression Technique: A Study of the Mediating Roles of World-Class Performance in Operations

Directory of Open Access Journals (Sweden)

Wakhid S. Ciptono

2010-05-01

mediating roles of the contextual factors of world-class performance in operations (i.e., world-class company practices or WCC, operational excellence practices or OE, company nonfinancial performance or CNFP, and the company financial performance would enable the company to facilitate the sustainability of TQM implementation model. This empirical study aims to assess how TQM—a holistic management philosophy initially developed by W. Edward Deming, which integrates improvement strategy, management practices, and organizational performance—is specifically implemented in the oil and gas companies operating in Indonesia. Relevant literature on the TQM, the world-class performance in operations (world-class company and operational performance, the company performance (financial and non-financial performances, and the amendments of the Law of the Republic of Indonesia concerning the oil and gas industry, and related research on how the oil and gas industry in Indonesia develops sustainable competitive advantage and sustainable development programs are reviewed in details in our study. The findings from data analysis provide evidence that there is a strong positive relationship between the critical factors of quality management practices and the company financial performance mediated by the three mediating variables, i.e., world-class company practices, operational excellence practices, and company non-financial performance.

Prayer and pain: the mediating role of positive re-appraisal.

Science.gov (United States)

Dezutter, Jessie; Wachholtz, Amy; Corveleyn, Jozef

2011-12-01

The present study explored in a sample of Flemish pain patients the role of prayer as a possible individual factor in pain management. The focus on prayer as a personal religious factor fits with the current religious landscape in Western-Europe where personal religious factors are more important than organizational dimensions of religion. Our study is framed in the transactional theory of stress and coping by testing first, whether prayer was related with pain severity and pain tolerance and second, whether cognitive positive re-appraisal was a mediating mechanism in the association between prayer and pain. We expected that prayer would be related to pain tolerance in reducing the impact of the pain on patient's daily life, but not necessarily to pain severity. A cross-sectional questionnaire design was adopted in order to measure demographics, prayer, pain outcomes (i.e., pain severity and pain tolerance), and cognitive positive re-appraisal. Two hundred and two chronic pain (CP) patients, all members of a Flemish national patients association, completed the questionnaires. Correlational analyses showed that prayer was significantly related with pain tolerance, but not with pain severity. However, ancillary analyses revealed a moderational effect of religious affiliation in the relationship between prayer and pain severity as well as pain tolerance. Furthermore, mediation analysis revealed that cognitive positive re-appraisal was indeed an underlying mechanism in the relationship between prayer and pain tolerance. This study affirms the importance to distinguish between pain severity and pain tolerance, and indicates that prayer can play a role in pain management, especially for religious pain patients. Further, the findings can be framed within the transactional theory of stress and coping as the results indicate that positive re-appraisal might be an important underlying mechanism in the association between prayer and pain.

Sources of sport confidence, imagery type and performance among competitive athletes: the mediating role of sports confidence.

Science.gov (United States)

Levy, A R; Perry, J; Nicholls, A R; Larkin, D; Davies, J

2015-01-01

This study explored the mediating role of sport confidence upon (1) sources of sport confidence-performance relationship and (2) imagery-performance relationship. Participants were 157 competitive athletes who completed state measures of confidence level/sources, imagery type and performance within one hour after competition. Among the current sample, confirmatory factor analysis revealed appropriate support for the nine-factor SSCQ and the five-factor SIQ. Mediational analysis revealed that sport confidence had a mediating influence upon the achievement source of confidence-performance relationship. In addition, both cognitive and motivational imagery types were found to be important sources of confidence, as sport confidence mediated imagery type- performance relationship. Findings indicated that athletes who construed confidence from their own achievements and report multiple images on a more frequent basis are likely to benefit from enhanced levels of state sport confidence and subsequent performance.

Justifying gender discrimination in the workplace: The mediating role of motherhood myths

Science.gov (United States)

2018-01-01

The issue of gender equality in employment has given rise to numerous policies in advanced industrial countries, all aimed at tackling gender discrimination regarding recruitment, salary and promotion. Yet gender inequalities in the workplace persist. The purpose of this research is to document the psychosocial process involved in the persistence of gender discrimination against working women. Drawing on the literature on the justification of discrimination, we hypothesized that the myths according to which women’s work threatens children and family life mediates the relationship between sexism and opposition to a mother’s career. We tested this hypothesis using the Family and Changing Gender Roles module of the International Social Survey Programme. The dataset contained data collected in 1994 and 2012 from 51632 respondents from 18 countries. Structural equation modellings confirmed the hypothesised mediation. Overall, the findings shed light on how motherhood myths justify the gender structure in countries promoting gender equality. PMID:29315326

Role development of nurses for technology-dependent children attending mainstream schools in Japan.

Science.gov (United States)

Shimizu, Fumie; Suzuki, Machiko

2015-04-01

To describe the role development of nurses caring for medical technology-dependent children attending Japanese mainstream schools. Semi-structured interviews with 21 nurses caring for technology-dependent children were conducted and analyzed using the modified grounded theory approach. Nurses developed roles centered on maintaining technology-dependent children's physical health to support children's learning with each other, through building relationships, learning how to interact with children, understanding the children and the school community, and realizing the meaning of supporting technology-dependent children. These findings support nurses to build relationships of mutual trust with teachers and children, and learn on the job in mainstream schools. © 2015, Wiley Periodicals, Inc.

Effect of intrinsic rewards on task performance of employees: Mediating role of motivation

Directory of Open Access Journals (Sweden)

Rizwan Qaiser Danish

2015-02-01

Full Text Available The basic purpose of this study was to examine the effect of reward management system, especially intrinsic rewards on task performance with the mediating role of extrinsic and intrinsic motivation of employees working in the banks in the capital of Punjab, Lahore, Pakistan. The secondary purpose of this study was to explore what level of performance these employees demonstrate towards their organizations when they are rewarded intrinsically and when they are motivated due to these reward management system accordingly. In this study, we collected data through self-administered questionnaires applying correlational explanatory research design. We distributed 300 questionnaires among which 290 were returned resulting in a response rate of 96%. The analysis of the data revealed that intrinsic rewards have positive impact on task performance of employees working in banks and motivation and its dimensions, i.e., intrinsic motivation, extrinsic motivation, and job satisfaction mediated this relationship. Considering the importance of appreciations received by bankers in the form of rewards and their effect on extra role performance and sophisticated management, policy makers should take necessary steps for improving the reward management system which will increase the task performance of employees because they will be motivated by these performance appraisal techniques.

Mediating role of self-determination constructs in explaining the relationship between school factors and postschool outcomes

NARCIS (Netherlands)

Shogren, Karrie A.; Villarreal, Mauricio Garnier; Lang, K.M.; Seo, Hyojeong

2017-01-01

Secondary data analysis using the National Longitudinal Transition Study-2 data set was conducted to examine the degree to which autonomy, psychological empowerment, and self-realization (3 of 4 essential characteristics of self-determination) play a mediating role in the relationship between

Micro dynamics in mediation

OpenAIRE

Boserup, Hans

2014-01-01

The author has identified a number of styles in mediation, which lead to different processes and different outcomes. Through discourse and conversation analysis he examines the micro dynamics in three of these, the postmodern styles: systemic, transformative and narrative mediation. The differences between the three mediation ideologies and practice is illustrated through role play scripts enacted in each style. Mediator and providers of mediation and trainers in mediation are encouraged to a...

Predicting Couples’ Happiness Based on Spiritual Intelligence and Lovemaking Styles: The Mediating Role of Marital adjustment

Directory of Open Access Journals (Sweden)

ZAHRA KERMANI MAMAZANDI

2017-02-01

Full Text Available The purpose of this study was to predict couples’ happiness based on spiritual intelligence and lovemaking styles with the mediating role of marital adjustment. Therefore 360 male and female, married students living in Tehran University dormitory were randomly selected and were asked to answer the items of Sternberg’s Love Questionnaire, King’s Spiritual Intelligence Scale, Oxford’s Happiness Questionnaire and Spanier’s Marital Adjustment Questionnaire. Structural equation modeling (path analysis was used for data analysis. The results  of path analysis showed  that spiritual intelligence and lovemaking styles have direct effects on couples’ happiness, and the spiritual intelligence did not have an indirect effect on couples’ happiness whereas lovemaking styles had indirect effects on couples’ happiness through martial satisfaction. Altogether the results of this research show that marital adjustment has a mediating role in predicting couples’ happiness based on spiritual intelligence and lovemaking styles.

Re-entry Adjustment and Job Embeddedness: The Mediating Role of Professional Identity in Indonesian Returnees.

Science.gov (United States)

Andrianto, Sonny; Jianhong, Ma; Hommey, Confidence; Damayanti, Devi; Wahyuni, Honey

2018-01-01

The present study examined the relationship between difficulty in re-entry adjustment and job embeddedness, considering the mediating role of sense of professional identity. The online data on demographic characteristics, difficulty on re-entry adjustment, sense of professional identity, and job embeddedness were collected from 178 Indonesian returnees from multiple organizations. The results showed that difficulty in re-entry adjustment was a significant predictor of a sense of professional identity; a sense of professional identity was a significant predictor of job embeddedness. Furthermore, sense of professional identity is an effective mediating variable, bridging the relationship between post-return conditions to the home country and work atmosphere. Finally, the key finding of this study was that sense of professional identity mediated the effect of difficulty in re-entry adjustment on job embeddedness. The theoretical and practical implications, study limitations, and future research needs of our findings are noted.

Role of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicity

International Nuclear Information System (INIS)

Kang, Su Jin; Ryoo, In-geun; Lee, Young Joon; Kwak, Mi-Kyoung

2012-01-01

Silver nanoparticles (nano-Ag) have been widely used in various commercial products including textiles, electronic appliances and biomedical products. However, there remains insufficient information on the potential risk of nano-Ag to human health and environment. In the current study, we have investigated the role of NF-E2-related factor 2 (Nrf2) transcription factor in nano-Ag-induced cytotoxicity. When Nrf2 expression was blocked using interring RNA expression in ovarian carcinoma cell line, nano-Ag treatment showed a substantial decrease in cell viability with concomitant increases in apoptosis and DNA damage compared to the control cells. Target gene analysis revealed that the expression of heme oxygenase-1 (HO-1) was highly elevated by nano-Ag in nonspecific shRNA expressing cells, while Nrf2 knockdown cells (NRF2i) did not increase HO-1 expression. The role of HO-1 in cytoprotection against nano-Ag was reinforced by results using pharmacological inducer of HO-1: cobalt protoporphyrin-mediated HO-1 activation in the NRF2i cells prevented nano-Ag-mediated cell death. Similarly, pharmacological or genetic inhibition of HO-1 in nonspecific control cells exacerbated nano-Ag toxicity. As the upstream signaling mechanism, nano-Ag required the phosphoinositide 3-kinase (PI3K) and p38MAPK signaling cascades for HO-1 induction. The treatment with either PI3K inhibitor or p38MAPK inhibitor suppressed HO-1 induction and intensified nano-Ag-induced cell death. Taken together, these results suggest that Nrf2-dependent HO-1 up-regulation plays a protective role in nano-Ag-induced DNA damage and consequent cell death. In addition, nano-Ag-mediated HO-1 induction is associated with the PI3K and p38MAPK signaling pathways. -- Highlights: ► Role of Nrf2 signaling in silver nanoparticle toxicity. ► Silver nanoparticle toxicity is increased by Nrf2 blockade. ► Nrf2-dependent HO-1 induction protects cells from silver nanoparticle toxicity. ► PI3K and p38MAPK cascades are

The mediating role of social workers in the implementation of regional policies targeting energy poverty

International Nuclear Information System (INIS)

Scarpellini, Sabina; Sanz Hernández, M. Alexia; Llera-Sastresa, Eva; Aranda, Juan A.; López Rodríguez, María Esther

2017-01-01

This paper aims to provide a socio-political reflection of the role played by social workers in regional policies and of the real needs of households affected by energy poverty. The paper also examines the impact of technical-specialised training on the ability of social workers to prevent and mitigate conditions of household energy poverty in Europe. The adoption of a research-action-participation methodological framework and a training research approach has permitted the opinions of social workers to be collected through surveys, and their central role in implementing regional policies to be highlighted. The conclusions obtained have made possible the construction of a self-diagnosis and data-collection tool which increases the ability of social workers to mediate and implement urgent mitigation measures for energy poverty. Finally, regional policies which aim to mitigate household energy poverty are examined from the professional perspective of social workers. - Highlights: • Social workers play a mediating role in the certification of household energy poverty. • Specific training for social workers contributes to the prevention of energy poverty. • National wide regulation would enable the implementation of equitable measures for energy poverty. • It is recommendable to define progressive subsidies depending on the level of energy vulnerability of the households.

Impaired cognitive control mediates the relationship between cortical thickness of the superior frontal gyrus and role functioning in schizophrenia.

Science.gov (United States)

Tully, Laura M; Lincoln, Sarah Hope; Liyanage-Don, Nadia; Hooker, Christine I

2014-02-01

Structural abnormalities in the lateral prefrontal cortex (LPFC) are well-documented in schizophrenia and recent evidence suggests that these abnormalities relate to functional outcome. Cognitive control mechanisms, reliant on the LPFC, are impaired in schizophrenia and predict functional outcome, thus impaired cognitive control could mediate the relationship between neuroanatomical abnormalities in the LPFC and functional outcome. We used surface-based morphometry to investigate relationships between cortical surface characteristics, cognitive control, and measures of social and role functioning in 26 individuals with schizophrenia and 29 healthy controls. Results demonstrate that schizophrenia participants had thinner cortex in a region of the superior frontal gyrus (BA10). Across all participants, decreased cortical thickness in this region related to decreased cognitive control and decreased role functioning. Moreover, cognitive control fully mediated the relationship between cortical thickness in the superior frontal gyrus and role functioning, indicating that neuroanatomical abnormalities in the LPFC adversely impact role functioning via impaired cognitive control processes. Copyright © 2013 Elsevier B.V. All rights reserved.

Core Self-Evaluation and Burnout among Nurses: The Mediating Role of Coping Styles

OpenAIRE

Li, Xiaofei; Guan, Lili; Chang, Hui; Zhang, Bo

2014-01-01

OBJECTIVES: This study aimed to determine the potential association between core self-evaluation and the burnout syndrome among Chinese nurses, and the mediating role of coping styles in this relationship. METHODS: A cross-sectional survey was conducted in Shenyang, China, from May to July, 2013. A questionnaire which consisted of the Maslach Burnout Inventory-General Survey (MBI-GS), the Core Self-Evaluation Scale (CSE), and the Simplified Coping Style Questionnaire (CSQ), was completed by a...

Peer Attachment, Coping, and Self-Esteem in Institutionalized Adolescents: The Mediating Role of Social Skills

Science.gov (United States)

Mota, Catarina Pinheiro; Matos, Paula Mena

2013-01-01

This study analyzes the contribution of peer attachment in predicting active coping and self-esteem in a sample of 109 institutionalized adolescents. It also explores the mediating role of social skills in the association between peer attachment, coping, and self-esteem. Structural equation modeling identified a model able to predict a positive…

Passion for an activity and quality of interpersonal relationships: the mediating role of emotions.

Science.gov (United States)

Philippe, Frederick L; Vallerand, Robert J; Houlfort, Nathalie; Lavigne, Geneviève L; Donahue, Eric G

2010-06-01

Our purpose in this research was to investigate the role of passion (Vallerand et al., 2003) for a given activity in the quality of interpersonal relationships experienced within the context of that activity in 4 studies. Study 1 demonstrated that a harmonious passion was positively associated with the quality of interpersonal relationships within the context of the passionate activity, whereas an obsessive passion was unrelated to it. Furthermore, in line with the broaden-and-build theory (Fredrickson, 2001), results also showed that positive emotions experienced at work fully mediated the relation between harmonious passion and quality of interpersonal relationships. Obsessive passion was not associated with positive emotions. Study 2 replicated the results from Study 1 while controlling for trait extraversion. Also, in Study 2, we examined the negative mediating role of negative emotions between obsessive passion and quality of interpersonal relationships. Finally, Studies 3 and 4 replicated the results of Study 2 with prospective designs and with objective ratings of interpersonal relationships quality. Implications for the dualistic model of passion and the broaden-and-build theory are discussed. (c) 2010 APA, all rights reserved).

Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery.

Science.gov (United States)

Wang, Changli; Ruan, Renquan; Zhang, Li; Zhang, Yunjiao; Zhou, Wei; Lin, Jun; Ding, Weiping; Wen, Longping

2015-04-06

In this work, we discovered that the Na(+)/K(+)-ATPase beta-subunit (ATP1B1) on epidermal cells plays a key role in the peptide-mediated transdermal delivery of macromolecular drugs. First, using a yeast two-hybrid assay, we screened candidate proteins that have specific affinity for the short peptide TD1 (ACSSSPSKHCG) identified in our previous work. Then, we verified the specific binding of TD1 to ATP1B1 in yeast and mammalian cells by a pull-down ELISA and an immunoprecipitation assay. Finally, we confirmed that TD1 mainly interacted with the C-terminus of ATP1B1. Our results showed that the interaction between TD1 and ATP1B1 affected not only the expression and localization of ATP1B1, but also the epidermal structure. In addition, this interaction could be antagonized by the exogenous competitor ATP1B1 or be inhibited by ouabain, which results in the decreased delivery of macromolecular drugs across the skin. The discovery of a critical role of ATP1B1 in the peptide-mediated transdermal drug delivery is of great significance for the future development of new transdermal peptide enhancers.

Role of receptor-mediated endocytosis in the antiangiogenic effects of human T lymphoblastic cell-derived microparticles.

Science.gov (United States)

Yang, Chun; Xiong, Wei; Qiu, Qian; Shao, Zhuo; Shao, Zuo; Hamel, David; Tahiri, Houda; Leclair, Grégoire; Lachapelle, Pierre; Chemtob, Sylvain; Hardy, Pierre

2012-04-15

Microparticles possess therapeutic potential regarding angiogenesis. We have demonstrated the contribution of apoptotic human CEM T lymphocyte-derived microparticles (LMPs) as inhibitors of angiogenic responses in animal models of inflammation and tumor growth. In the present study, we characterized the antivascular endothelial growth factor (VEGF) effects of LMPs on pathological angiogenesis in an animal model of oxygen-induced retinopathy and explored the role of receptor-mediated endocytosis in the effects of LMPs on human retinal endothelial cells (HRECs). LMPs dramatically inhibited cell growth of HRECs, suppressed VEGF-induced cell migration in vitro experiments, and attenuated VEGF-induced retinal vascular leakage in vivo. Intravitreal injections of fluorescently labeled LMPs revealed accumulation of LMPs in retinal tissue, with more than 60% reductions of the vascular density in retinas of rats with oxygen-induced neovascularization. LMP uptake experiments demonstrated that the interaction between LMPs and HRECs is dependent on temperature. In addition, endocytosis is partially dependent on extracellular calcium. RNAi-mediated knockdown of low-density lipoprotein receptor (LDLR) reduced the uptake of LMPs and attenuated the inhibitory effects of LMPs on VEGF-A protein expression and HRECs cell growth. Intravitreal injection of lentivirus-mediated RNA interference reduced LDLR protein expression in retina by 53% and significantly blocked the antiangiogenic effects of LMPs on pathological vascularization. In summary, the potent antiangiogenic LMPs lead to a significant reduction of pathological retinal angiogenesis through modulation of VEGF signaling, whereas LDLR-mediated endocytosis plays a partial, but pivotal, role in the uptake of LMPs in HRECs.

The Role of Universities in Technology Entrepreneurship

Directory of Open Access Journals (Sweden)

Jonathan Wells

2012-04-01

Full Text Available This article discusses the role that universities play in the process of technology entrepreneurship, where entrepreneurship is restricted to the process of launching and supporting small and medium-sized technology-based businesses. The article briefly discusses a few of the issues that influence a university’s participation in the process of entrepreneurship. Although there is no “one-size-fits-all” model, the article discusses various ways that Canadian universities may help entrepreneurs, including contract research, the provision of business parks, and sensible handling of intellectual property issues. Finally, the article suggests that the return on “investment”, for both the university and the province, is a difficult thing to measure – nevertheless, participation in the entrepreneurship process may result in some tangible and intangible benefits for both parties.

The Role of Sociocultural Influences on Symptoms of Muscle Dysmorphia and Eating Disorders in Men, and the Mediating Effects of Perfectionism.

Science.gov (United States)

Dryer, Rachel; Farr, Melissa; Hiramatsu, Izumi; Quinton, Stephanie

2016-01-01

This study examined the mediating role of self-oriented and socially prescribed perfectionism in the relationship between sociocultural influences (i.e., media, peer, and teasing) and symptoms of muscle dysmorphia (MD) and eating disorders (ED). A nonclinical sample of males (N = 158, Mage = 26.94, SD = 5.50) completed measures of perfectionism, MD, body dissatisfaction, drive for thinness, and bulimia. Susceptibility to appearance-based messages from the media, their peers, and family was also measured. Analyses confirmed the partial mediating role of self-oriented perfectionism only for drive for thinness. In contrast, socially prescribed perfectionism was found to be a partial mediator between all three sociocultural variables and measures of both MD and ED; except for those between peer influence and body dissatisfaction, and teasing and bulimia symptomatology. These two relationships were fully mediated by socially prescribed perfectionism. Results suggest that vulnerability to MD and ED depend on pre-existing perfectionistic attitudes, particularly that of socially prescribed perfectionism.

Mentalizing and interpersonal problems in borderline personality disorder: The mediating role of identity diffusion.

Science.gov (United States)

De Meulemeester, Celine; Lowyck, Benedicte; Vermote, Rudi; Verhaest, Yannic; Luyten, Patrick

2017-12-01

Individuals with borderline personality disorder (BPD) are characterized by problems in interpersonal functioning and their long-term social integration often remains problematic. Extant theories have linked identity diffusion to many of the interpersonal problems characteristic of BPD patients. Recent theoretical accounts have suggested that identity diffusion results from problems with mentalizing or reflective functioning, that is, the capacity to understand oneself and others in terms of intentional mental states. In this study we tested these assumptions, i.e., whether identity diffusion plays a mediating role in the relationship between mentalizing difficulties and interpersonal problems, in a sample of 167 BPD patients. Highly significant correlations were found between mentalizing impairments, identity diffusion and interpersonal problems. Mediation analyses showed that identity diffusion fully mediated the relationship between mentalizing difficulties and interpersonal problems. This study provides preliminary evidence that impairments in mentalizing are related to identity diffusion, which in turn is related to interpersonal problems in BPD. Further longitudinal research is needed to further substantiate these conclusions. Copyright © 2017 Elsevier B.V. All rights reserved.

Stereotype threat as a determinant of burnout or work engagement. Mediating role of positive and negative emotions.

Science.gov (United States)

Bedyńska, Sylwia; Żołnierczyk-Zreda, Dorota

2015-01-01

Stereotype threat as an example of serious interpersonal strain at workplace can lead either to impaired work engagement or it can motivate workers to strengthen their efforts to disconfirm a stereotype and can result in excessive work engagement. Thus, the basic aim of the study was to examine whether stereotype threat is related to burnout or to work engagement. The mediating role of the negative and positive emotions were also tested in the classical approach. Mediational analysis revealed a linear relation of stereotype threat and burnout, mediated by negative emotions and a quadratic relationship between stereotype threat and work engagement. In the latter analysis none of the mediators were significant. Therefore, the results showed that both burnout and work engagement are associated with stereotype threat at the workplace, probably depending on the stage of response to the stereotype threat. Further research should confirm these associations in a longitudinal study.

The role of the IAEA in advanced technologies for water-cooled reactors

International Nuclear Information System (INIS)

Cleveland, J.

1996-01-01

The role of the IAEA in advanced technologies for water-cooled reactors is described, including the following issues: international collaboration ways through international working group activities; IAEA coordinated research programmes; cooperative research in advanced water-cooled reactor technology

The mediational role of panic self-efficacy in cognitive behavioral therapy for panic disorder: A systematic review and meta-analysis

DEFF Research Database (Denmark)

Fentz, Hanne Nørr; Arendt, Mikkel; OToole, Mia Skytte

2014-01-01

Cognitive models of panic disorder (PD) with and without agoraphobia have stressed the role of catastrophic beliefs of bodily symptoms as a central mediating variable of the efficacy of cognitive behavioral therapy (CBT). Perceived ability to cope with or control panic attacks, panic self......-efficacy, has also been proposed to play a key role in therapeutic change; however, this cognitive factor has received much less attention in research. The aim of the present review is to evaluate panic self-efficacy as a mediator of outcome in CBT for PD using descriptive and meta-analytic procedures. We...... an association between change in panic self-efficacy and change in outcome during therapy (criterion 2); three tested, and one established formal statistical mediation of panic self-efficacy (criterion 3); while four tested and three found change in panic self-efficacy occurring before the reduction of panic...

Articular chondrocyte network mediated by gap junctions: role in metabolic cartilage homeostasis

Science.gov (United States)

Mayan, Maria D; Gago-Fuentes, Raquel; Carpintero-Fernandez, Paula; Fernandez-Puente, Patricia; Filgueira-Fernandez, Purificacion; Goyanes, Noa; Valiunas, Virginijus; Brink, Peter R; Goldberg, Gary S; Blanco, Francisco J

2017-01-01

Objective This study investigated whether chondrocytes within the cartilage matrix have the capacity to communicate through intercellular connections mediated by voltage-gated gap junction (GJ) channels. Methods Frozen cartilage samples were used for immunofluorescence and immunohistochemistry assays. Samples were embedded in cacodylate buffer before dehydration for scanning electron microscopy. Co-immunoprecipitation experiments and mass spectrometry (MS) were performed to identify proteins that interact with the C-terminal end of Cx43. GJ communication was studied through in situ electroporation, electrophysiology and dye injection experiments. A transwell layered culture system and MS were used to identify and quantify transferred amino acids. Results Microscopic images revealed the presence of multiple cellular projections connecting chondrocytes within the matrix. These projections were between 5 and 150 μm in length. MS data analysis indicated that the C-terminus of Cx43 interacts with several cytoskeletal proteins implicated in Cx trafficking and GJ assembly, including α-tubulin and β-tubulin, actin, and vinculin. Electrophysiology experiments demonstrated that 12-mer oligonucleotides could be transferred between chondrocytes within 12 min after injection. Glucose was homogeneously distributed within 22 and 35 min. No transfer was detected when glucose was electroporated into A549 cells, which have no GJs. Transwell layered culture systems coupled with MS analysis revealed connexins can mediate the transfer of L-lysine and L-arginine between chondrocytes. Conclusions This study reveals that intercellular connections between chondrocytes contain GJs that play a key role in cell-cell communication and a metabolic function by exchange of nutrients including glucose and essential amino acids. A three-dimensional cellular network mediated through GJs might mediate metabolic and physiological homeostasis to maintain cartilage tissue. PMID:24225059

THE MEDIATING ROLE OF SCIENCE MUSEUM IN STRUCTURING AND SYNTHESIS OF LEARNING

Directory of Open Access Journals (Sweden)

Fanny Angulo Delgado

2016-10-01

Full Text Available Understanding the mediating role of science museum in learning scientific content in school, it involves reflecting on the contributions of research to the question of what and how people learn in non-conventional educational settings. It has been shown that most people spend less than 3% of their lives learning in school, which emphasizes the importance of conceptualizing what they are and how much of their learning take place. While that question is resolved, it speaks at this bioassay on the complementary relationship between the museum and the school, as both institutions share the same educational purpose, but differ in the ways of achieving it. The science museum joins the class as a mediator that facilitates student learning as part of an education that promotes understanding of the phenomena of the world through models, which means that school learning goes in stages, one of which is that students have opportunity to structure new knowledge and synthesize on its own model. For this it is necessary that students speak, read, listen and write in science class, while the thought is expressed in language to attest to the facts. These communication skills arise in science class as indicators of mediation exercised by the museum and allow us to understand that it takes place in at least two dimensions: museographic and didactics.

A Closer Look at Intergroup Threat Within the Dual Process Model Framework: The Mediating Role of Moral Foundations

Directory of Open Access Journals (Sweden)

Márton Hadarics

2017-04-01

Full Text Available In our study we investigated how right-wing authoritarianism (RWA and social dominance orientation (SDO are related to perceived intergroup threat, and also tested the potential mediating role of individualizing and binding moral foundations within this relationship pattern. According to our results, both RWA and SDO enhanced the perceived threat related to immigration. Furthermore, the effect of SDO was partly mediated by individualizing moral foundations, while the effect of RWA was partly mediated by both kinds of moral foundations. It seems that perceived intergroup threat, at least to some extent, is influenced by personal moral preferences that can be derived from individual dispositions and motivations.

Workplace Bullying as a Risk Factor for Musculoskeletal Disorders: The Mediating Role of Job-Related Psychological Strain

Directory of Open Access Journals (Sweden)

Michela Vignoli

2015-01-01

Full Text Available Workplace bullying is considered by the European Agency for Safety and Health at Work one of the emerging psychosocial risk factors that could negatively affect workers’ health. Thus, the aim of this study was to analyze the process that leads from bullying to negative health (such as musculoskeletal disorders (MSDs, testing the mediating role of job-related strain. Data were collected on 512 workers (62.9% female; mean age = 43.6 years of a retail chain who filled in a self-report questionnaire after a one-hour training session on work-related stress. Data analyses were performed controlling for potentially confounding variables (i.e., gender, age, organizational role, type of contract, and perceived physical job demands. Preacher and Hayes analytical approach was used to test the indirect relationship between bullying and MSDs. Results showed that work-related strain mediates the relationship between bullying and MSDs considered (low back, upper back, and neck except for MSDs of the shoulders. Our study confirms the role played by bullying and job-related strain in determining workers’ MSDs.

Workplace Bullying as a Risk Factor for Musculoskeletal Disorders: The Mediating Role of Job-Related Psychological Strain.

Science.gov (United States)

Vignoli, Michela; Guglielmi, Dina; Balducci, Cristian; Bonfiglioli, Roberta

2015-01-01

Workplace bullying is considered by the European Agency for Safety and Health at Work one of the emerging psychosocial risk factors that could negatively affect workers' health. Thus, the aim of this study was to analyze the process that leads from bullying to negative health (such as musculoskeletal disorders (MSDs)), testing the mediating role of job-related strain. Data were collected on 512 workers (62.9% female; mean age = 43.6 years) of a retail chain who filled in a self-report questionnaire after a one-hour training session on work-related stress. Data analyses were performed controlling for potentially confounding variables (i.e., gender, age, organizational role, type of contract, and perceived physical job demands). Preacher and Hayes analytical approach was used to test the indirect relationship between bullying and MSDs. Results showed that work-related strain mediates the relationship between bullying and MSDs considered (low back, upper back, and neck) except for MSDs of the shoulders. Our study confirms the role played by bullying and job-related strain in determining workers' MSDs.

Prospective Teachers' Future Time Perspective and Professional Plans about Teaching: The Mediating Role of Academic Optimism

Science.gov (United States)

Eren, Altay

2012-01-01

This study aimed to examine the mediating role of prospective teachers' academic optimism in the relationship between their future time perspective and professional plans about teaching. A total of 396 prospective teachers voluntarily participated in the study. Correlation, regression, and structural equation modeling analyses were conducted in…

Protective role of complement C3 against cytokine-mediated beta cell apoptosis

DEFF Research Database (Denmark)

Dos Santos, R. S.; Marroqui, L.; Grieco, F. A.

2017-01-01

Background and aims: Type 1 diabetes is a chronic autoimmune disease characterized by pancreatic islet inflammation and β-cell destruction by pro-inflammatory cytokines and other mediators. The complement system, a major component of the immune system, has been recently shown to also act in metab...... in metabolic organs, such as liver, adipose tissue, and pancreas. In the present study we identified complement C3 as an important hub of a cytokine-modified complement network in human islets and characterized the role of C3 in β-cell survival....

Family Environments and Children's Executive Function: The Mediating Role of Children's Affective State and Stress.

Science.gov (United States)

He, Zhong-Hua; Yin, Wen-Gang

2016-09-01

There is increasing evidence that inadequate family environments (family material environment and family psychosocial environment) are not only social problems but also factors contributing to adverse neurocognitive outcomes. In the present study, the authors investigated the relationship among family environments, children's naturalistic affective state, self-reported stress, and executive functions in a sample of 157 Chinese families. These findings revealed that in inadequate family material environments, reduced children's cognitive flexibility is associated with increased naturalistic negative affectivity and self-reported stress. In addition, naturalistic negative affectivity mediated the association between family expressiveness and children's cognitive flexibility. The authors used a structural equation model to examine the mediation model hypothesis, and the results confirmed the mediating roles of naturalistic negative affectivity and self-reported stress between family environments and the cognitive flexibility of Chinese children. These findings indicate the importance of reducing stress and negative emotional state for improving cognitive functions in children of low socioeconomic status.

Teammate Prosocial and Antisocial Behaviors Predict Task Cohesion and Burnout: The Mediating Role of Affect.

Science.gov (United States)

Al-Yaaribi, Ali; Kavussanu, Maria

2017-06-01

The manner in which teammates behave toward each other when playing sport could have important achievement-related consequences. However, this issue has received very little research attention. In this study, we investigated whether (a) prosocial and antisocial teammate behaviors predict task cohesion and burnout, and (b) positive and negative affect mediates these relationships. In total, 272 (M age  = 21.86, SD = 4.36) team-sport players completed a multisection questionnaire assessing the aforementioned variables. Structural equation modeling indicated that prosocial teammate behavior positively predicted task cohesion and negatively predicted burnout, and these relationships were mediated by positive affect. The reverse pattern of relationships was observed for antisocial teammate behavior which negatively predicted task cohesion and positively predicted burnout, and these relationships were mediated by negative affect. Our findings underscore the importance of promoting prosocial and reducing antisocial behaviors in sport and highlight the role of affect in explaining the identified relationships.

Emotional contagion of dental fear to children: the fathers' mediating role in parental transfer of fear.

Science.gov (United States)

Lara, America; Crego, Antonio; Romero-Maroto, Martin

2012-09-01

Dental fear is considered to be one of the most frequent problems in paediatric dentistry. According to literature, parents' levels of dental fear play a key role in the development of child's dental anxiety. HYPOTHESIS OR AIM: We have tried to identify the presence of emotional transmission of dental fear among family members and to analyse the different roles that mothers and fathers might play concerning the contagion of dental fear to children. We have hypothesized a key role of the father in the transfer of dental fear from mother to child. A questionnaire-based survey (Children's Fear Survey Schedule-Dental Subscale) has been distributed among 183 schoolchildren and their parents in Madrid (Spain). Inferential statistical analyses, i.e. correlation and hierarchical multiple regression, were carried out and possible mediating effects between variables have been tested. Our results support the hypothesis that family members' levels of dental fear are significantly correlated, and they also allow us to affirm that fathers' dental fear is a mediating variable in the relationship between mothers and children's fear scores. Together with the presence of emotional transmission of dental fear among family members, we identified the relevant role that fathers play as regards the transfer of dental fear from parents to children. © 2011 The Authors. International Journal of Paediatric Dentistry © 2011 BSPD, IAPD and Blackwell Publishing Ltd.

The Effect of Self-Esteem on Corrupt Intention: The Mediating Role of Materialism

OpenAIRE

Liang, Yuan; Liu, Li; Tan, Xuyun; Huang, Zhenwei; Dang, Jianning; Zheng, Wenwen

2016-01-01

The present set of studies aimed to explore the effect of self-esteem on corrupt intention and the mediating role of materialism in generating this effect. In Study 1, we used questionnaires to investigate the correlation among self-esteem, materialism, and corrupt intention. In Study 2, we manipulated self-esteem to explore the causal effect of self-esteem on materialism and corrupt intention. In Study 3, we manipulated materialism to examine whether inducing materialism can reduce the relat...

THE ROLE OF CUSTOMER SATISFACTION IN MEDIATING MARKETING COMMUNICATION EFFECT ON CUSTOMER LOYALTY

OpenAIRE

Mohamad Dimyati,

2015-01-01

This study aims to test the effect of a) marketing communication on customer satisfaction; b) marketing communication on customer loyalty; c) customer satisfaction on customer loyalty; and d) to identify the role of customer satisfaction in mediating marketing communication effect on customer loyalty of the IM3 user community in Jember regency, East Java province. The study was designed in a form confirmatory research, with the whole IM3 community members in the regency as the ...

Ethnic and racial socialization and self-esteem of Asian adoptees: the mediating role of multiple identities.

Science.gov (United States)

Mohanty, Jayashree

2013-02-01

Positive identity development during adolescence in general is a complex process and may pose additional challenges for adolescents adopted from a different culture. Using a web-based survey design with a sample of 100 internationally adopted Asian adolescent and young adults, the present study examined the mediating role of multiple identities (i.e., ethnic, adoptive and interpersonal ego identities) in explaining the relationship between ethnic and racial socializations, ethnic neighborhood, and self-esteem. The results showed that (a) adoptive identity mediated the influence of racial socialization on psychological well-being, and (b) ethnic affirmation mediated the influence of ethnic socialization on adoptees' well-being. This study illustrates the importance of providing supportive counseling services for adoptees who are exploring their adoptive identity. Copyright © 2012 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

The Mediator Effect of Career Development between Personality Traits and Organizational Commitment: The Example of Sport Communication Technology Talents

Science.gov (United States)

Lo, Hung-Jen; Lin, Chun-Hung; Tung-Hsing, Lin; Tu, Peng-Fei

2014-01-01

This paper explored the relationships among career development, personality trait, and organizational commitment and examines whether career development mediates the relationship between personality trait and organizational commitment. The sample was 275 sport communication technology talents in Taiwan. The instrument included the Personality…

The Strategic Mediator

DEFF Research Database (Denmark)

Rossignoli, Cecilia; Carugati, Andrea; Mola, Lapo

2009-01-01

process. Through the study of services evolving over time we show that, as marketplaces support increasingly complex business processes, the market participants begin to privilege the well connected small number to the convenience of the openness to the entire market. The participants see the marketplace......The last 10 years have witnessed the emergence of electronic marketplaces as players that leverage new technologies to facilitate B2B internet-mediated collaborative business. Nowadays these players are augmenting their services from simple intermediation to include new inter......-organizational relationships. The interest of this paper is to investigate the shift in the role and evolution of services proposed by e-marketplaces in response to the demands of the market participants. We carried out a longitudinal qualitative field study of an e-marketplace providing the outsourcing of the procurement...

Mediator: A key regulator of plant development.

Science.gov (United States)

Buendía-Monreal, Manuel; Gillmor, C Stewart

2016-11-01

Mediator is a multiprotein complex that regulates transcription at the level of RNA pol II assembly, as well as through regulation of chromatin architecture, RNA processing and recruitment of epigenetic marks. Though its modular structure is conserved in eukaryotes, its subunit composition has diverged during evolution and varies in response to environmental and tissue-specific inputs, suggesting different functions for each subunit and/or Mediator conformation. In animals, Mediator has been implicated in the control of differentiation and morphogenesis through modulation of numerous signaling pathways. In plants, studies have revealed roles for Mediator in regulation of cell division, cell fate and organogenesis, as well as developmental timing and hormone responses. We begin this review with an overview of biochemical mechanisms of yeast and animal Mediator that are likely to be conserved in all eukaryotes, as well as a brief discussion of the role of Mediator in animal development. We then present a comprehensive review of studies of the role of Mediator in plant development. Finally, we point to important questions for future research on the role of Mediator as a master coordinator of development. Copyright © 2016 Elsevier Inc. All rights reserved.

Technology as a factor of identity transformation: development of HOMO TECHNOLOGIES

Directory of Open Access Journals (Sweden)

Vadim A. Emelin

2016-03-01

Full Text Available Based on the understanding of identity as an individual’s identity with the self within the cultural historical chronotope, and experienced as the feeling of belonging/ non-belonging to some communities, controllability/uncontrollability of situations and predictability/non-predictability of events, the paper describes the processes of identity transformation in the course of a technological development. Taken as the initial point, the idea of organ-extension (K. Marx, E. Kapp and technological extension of man (S. Freud, M. McLuhan means that technologies are the extension of a human body and its organs. The processes of technological extension assume a particular scale under condition of information society development, within which computer-, telecommunication-, transport-, bio-, nano- and other high technologies have become an actual cultural historical force that has a power to transform a human. Special attention is paid to the fact that unlike the precedent technologies that have just facilitated some or other human performance, modern technologies of information society do not only change the human topology, widen and expand human natural abilities but also really transform higher mental functions and mediate mental processes and relations between human individuals. Man becomes not only a biological and social creature but also a technological one, i.e. so called HOMO TECHNOLOGICUS. The scale and speed of cultural historical changes make the study of the technological extensions role in the transformation of identity a key point for developing ways of comprehending their role in the life of a modern person, and also for forecasting the evolution of relationship between man and machines in the future.

Need for Social Approval and Happiness in College Students: The Mediation Role of Social Anxiety

Science.gov (United States)

Karasar, Burcu; Baytemir, Kemal

2018-01-01

The reflection of the presence or absence of social relationships as a basic human need on the individual has been investigated in different ways. The purpose of the current study is to investigate the mediation role of social anxiety in the relationship between the need for social approval and happiness. A total of 285 students, of whom 212…

Role of very late antigen-1 in T-cell-mediated immunity to systemic viral infection

DEFF Research Database (Denmark)

Ørding Kauffmann, Susanne; Thomsen, Allan Randrup; Christensen, Jan Pravsgaard

2006-01-01

or their distribution between lymphoid and nonlymphoid organs. Regarding a functional role of VLA-1, we found that intracerebral infection of both VLA-1(-/-) and wild-type (wt) mice resulted in lethal T-cell-mediated meningitis, and quantitative and qualitative analyses of the cellular exudate did not reveal any...... significant differences between the two strains. Expression of VLA-1 was also found to be redundant regarding the ability of effector T cells to eliminate virus from internal organs of i.v. infected mice. Using delayed-type hypersensitivity (DTH) assays to evaluate subdermal CD8(+) T......, the current findings indicate that the expression of VLA-1 is not pivotal for T-cell-mediated antiviral immunity to a systemic infection....

On the Convergence of Affective and Persuasive Technologies in Computer- Mediated Health-Care Systems

Directory of Open Access Journals (Sweden)

Rebeca I. García-Betances

2015-01-01

Full Text Available This paper offers a portrayal of how affective computing and persuasive technologies can converge into an effective tool for interfacing biomedical engineering with behavioral sciences and medicine. We describe the characteristics, features, applications, present state of the art, perspectives, and trends of both streams of research. In particular, these streams are analyzed in light of the potential contribution of their convergence for improving computer-mediated health-care systems, by facilitating the modification of patients’ attitudes and behaviors, such as engagement and compliance. We propose a framework for future research in this emerging area, highlighting how key constructs and intervening variables should be considered. Some specific implications and challenges posed by the convergence of these two technologies in health care, such as paradigm change, multimodality, patients’ attitude improvement, and cost reduction, are also briefly addressed and discussed.

LMS Use and Instructor Performance: The Role of Task-Technology Fit

Science.gov (United States)

McGill, Tanya; Klobas, Jane; Renzi, Stefano

2011-01-01

The introduction of learning management systems (LMS) has changed the way in which instructors work. This paper uses Goodhue and Thompson's (1995) technology-to-performance chain (TPC) to explore the roles of task-technology fit (TTF) and level of LMS use in the performance impacts of LMS for instructors. A mixed method approach was used: an…

The role of technological innovation in creating radically new product meanings

DEFF Research Database (Denmark)

Krabbe, Anders Dahl

2015-01-01

This paper explores the concept of technological epiphanies from the literature on design driven innovation. A technological epiphany is defined as a product innovation that can be considered radical, both in terms of technology as well as the meaning and experiences it creates through its design....... Three cases of technological epiphanies from the hearing aid industry are analyzed and discussed in terms of how they represent a radical innovation in technology as well as in product meaning and which role the technological aspect has played in the radical innovation of the meaning of the product....... Three different ways in which technology can function as an enabler for the innovation of product meanings are explored and a fourth is found is found during the analysis. The paper concludes by suggesting directions for future research....

[Relationship of childhood physical abuse and internet addiction disorder in adolescence: the mediating role of self-esteem].

Science.gov (United States)

Zhang, Zhi-hua; Yang, Lin-sheng; Hao, Jia-hu; Huang, Fen; Zhang, Xiu-jun; Sun, Ye-huan

2012-01-01

To find out whether the effects of childhood physical abuse on internet addiction disorder in adolescence could be mediated by self-esteem. 3798 high school students selected from 76 classes in Grade One and Grade Two, were asked to fill in the anonymous questionnaire, which including the demographic characteristics of students, Young's Internet Addiction Scale, Parent-Child Conflict Tactics Scales and Rosenberg's Self-Esteem Scale. Childhood physical abuse could directly predict less self-esteem and internet addiction disorder (r = -0.108, P self-esteem (a = -0.703, standardized b = -0.104, z = 5.052, P Self-esteem had mediated 22.5% of the childhood physical abuse cases on their internet addiction disorders during the period of adolescence. Self-esteem could partially mediate the relationship between childhood physical abuse and internet addiction disorder. The mediating roles of self-esteem suggested that salient leverage points could make a change through empowerment training, self-esteem group training on self-esteem enhancement in the stage of adolescence.

The material of the social: the mutual shaping of institutions by irrigation technology and society in Seguia Khrichfa, Morocco

NARCIS (Netherlands)

Kooij, van der S.; Zwarteveen, M.Z.; Kuper, M.

2015-01-01

In this paper we draw attention to the important role technology plays in co-mediating institutions, opening up some courses of action and closing off others. Irrigation studies generally recognize the importance of institutions in making technologies work, but tend to take the precise functioning

The material of the social: the mutual shaping of institutions by irrigation technology and society in Sequia Krichfa, Morocco

NARCIS (Netherlands)

van der Kooij, S.; Zwarteveen, M.; Kuper, M.

2015-01-01

In this paper we draw attention to the important role technology plays in co-mediating institutions, opening up some courses of action and closing off others. Irrigation studies generally recognize the importance of institutions in making technologies work, but tend to take the precise functioning

Maternal Emotion Regulation and Adolescent Behaviors: The Mediating Role of Family Functioning and Parenting.

Science.gov (United States)

Crandall, AliceAnn; Ghazarian, Sharon R; Day, Randal D; Riley, Anne W

2016-11-01

Prior research links poor maternal emotion regulation to maladaptive parenting and child behaviors, but little research is available on these relationships during the adolescent period. We use structural equation modeling to assess the influence of poor maternal emotion regulation, measured as emotional reactivity and distancing, on adolescent behaviors (measured as aggression and prosocial behaviors) among 478 adolescents (53 % female; baseline age 10-13 years) and their mothers over a 5 year period. We also tested the possible mediating roles of family functioning and parenting behaviors between maternal emotion regulation and adolescent behaviors. Results indicated that higher baseline maternal emotional distancing and reactivity were not directly predictive of adolescents' behaviors, but they were indirectly related through family functioning and parenting. Specifically, indulgent parenting mediated the relationship between maternal emotional reactivity and adolescent aggression. Maternal-reported family functioning significantly mediated the relationship between maternal emotional distancing and adolescent aggression. Family functioning also mediated the relationship between emotional distancing and regulation parenting. The results imply that poor maternal emotion regulation during their child's early adolescence leads to more maladaptive parenting and problematic behaviors during the later adolescent period. However, healthy family processes may ameliorate the negative impact of low maternal emotion regulation on parenting and adolescent behavioral outcomes. The implications for future research and interventions to improve parenting and adolescent outcomes are discussed.

Health technology assessment in Australia: The role of AHTAC

International Nuclear Information System (INIS)

Kearney, B.; Willis, E.

1997-01-01

This paper outlines and discusses the field of medical technology assessment and the role of the Australian Health Technology Advisory Committee (AHTAC) in that process. Developments in medical technologies have altered the way in which health care is practised and delivered. As part of its work program, AHTAC has re-evaluating some existing medical technologies to assess how and under what circumstances new developments can contribute to the alleviation of the illness and suffering of the patients. Three case studies are described. These are: magnetic resonance imaging, diagnostic ultrasound and beam and isotope radiotherapy. It is stressed that the policy task is a complex one attempting to balance the need for cost containment whilst at the same time ensuring that the processes of innovation into Australia and diffusion occur in a manner which maximizes the benefit and minimizes any harm to the Australian community

The Relationship Between Perceived Parental Bonding and Bullying: The Mediating Role of Empathy

Directory of Open Access Journals (Sweden)

Effrosyni Mitsopoulou

2013-03-01

Full Text Available Despite the importance of parenting in the development of empathy in children as well as their involvement in bullying behaviours, no study has ever examined the mediating role of empathy in the relationship between parental bonding and bullying and victimization. The present study aims in examining these relationships. Participants included 504 children (255 boys, 246 girls from different primary schools of Crete. The standard version of the Peer Experiences Questionnaire was used to assess experiences in bullying behaviours, the Parental Bonding Instrument was used to assess self-reported sense of care and overprotection from the mother and father separately, whereas empathy was assessed using the Greek version of Bryant’s Empathy Index. A series of multiple regression analyses were conducted. Results showed that boys scored significantly higher on average with respect to Victimisation of Others, and girls scored higher to specific sub-factors of empathy. It was also found that in the case of Care Mother, Sadness and Understanding of Feelings were significant mediators of Victimization of Others. Further, in the subsample of boys it was revealed that Sadness and Understanding of Feelings were significant mediators of the relationship between Care Mother and Victimization of Others. Implications for counselling interventions are also discussed.

EXPLORING MEDIATING ROLE OF INSTITUTIONAL IMAGE THROUGH A COMPLETE STRUCTURAL EQUATION MODELING (SEM: A PERSPECTVE OF HIGHER EDUCATION

Directory of Open Access Journals (Sweden)

Abu Osman

2018-06-01

Full Text Available The prime objective of this study is to investigate the mediating role of institutional image between student satisfaction, program quality, and service quality in the context of higher education. To attain this aim, the Nordic model was used as theoretical foundation of the study. The Structural Equation Modeling (SEM was used to analyze the influence of mediating variable and hypotheses testing. The population of this study was fourth-year business students of nine 'grade one' private universities in Bangladesh. Data (n=310 were gathered from students pursuing studies at different private universities in Bangladesh. The findings of this study revealed that image occupied full mediation role between student satisfaction and service quality. Furthermore, it also disclosed that the direct path of student satisfaction and service quality was not statistically significant. These exceptional findings indicate that academic experts should promote the institutional image, student satisfaction and program quality rigorously in order to enhance service quality of education. The outcomes of this study would provide substantial benefits to both practitioners and academics, especially in the context of private higher education. There is a deficiency of indirect link between student satisfaction, program quality and service quality. This study has integrated institutional image as a mediating variable to fulfill the deficiency between student satisfaction, program quality, and service quality.

Associated technologies ensures complete loop mediated ...

African Journals Online (AJOL)

Loop Mediated Isothermal Amplification (LAMP) assay could be a useful adjunct diagnostic assay along with the conventional methods that would preclude the requirement of continuous maintenance of pure cultures. Moreover, LAMP assay is simple, rapid, specific and sensitive for the detection of pathogens. Having ...

A snapshot of research in learning technology

Directory of Open Access Journals (Sweden)

Rhona Sharpe

2010-12-01

Full Text Available The papers in this issue present a convenient snapshot of current research in learning technology, both in their coverage of the issues that concern us and the methods that are being used to investigate them. This issue shows that e-learning researchers are interested in: what technologies are available and explorations of their potential (Nie et al. explore the role of podcasting, how to design technology-mediated learning activities in ways which support specific learning outcomes (Simpson evaluates the role of ‘book raps' in supporting critical thinking, the identification of critical success factors in implementations (Cochrane's observation of three mobile learning projects and how such e-learning initiatives can be sustained within an institutional context (Gunn's examination of the challenges of embedding ‘grass roots' initiatives. Finally e-learning research is concerned with investigating the impact of emerging technologies on education – in this case Traxler's discussion of mobile, largely student-owned, devices. Together these five papers demonstrate the scope of research in learning technology and it is with this in mind that we will soon be referring to this journal by its subtitle: Research in Learning Technology.

Leader-member exchange and work-family interactions: the mediating role of self-reported challenge- and hindrance-related stress.

Science.gov (United States)

Culbertson, Satoris S; Huffman, Ann H; Alden-Anderson, Rachel

2010-01-01

The authors examined the relations among 4 components of the leader-member exchange (LMX) relationship (i.e., contribution, affect, loyalty, and professional respect) and the level of work-family conflict and work-family facilitation that an employee experiences. Further, the authors examined the mediating role of challenge- and hindrance-related self-reported stress on relations. In doing this, the authors linked positive and negative aspects of LMX, stressors, work-family conflict, and work-family facilitation. Data from a sample of full-time employed individuals support some hypothesized relations between components of LMX and work-family interactions. Also, results support the mediating role of hindrance-related stress in the relation between (a) the affect and loyalty components of LMX and (b) work-family conflict. The authors discuss the implications and limitations of their findings.

Teaching Mediated Public Relations.

Science.gov (United States)

Kent, Michael L.

2001-01-01

Discusses approaches to teaching a mediated public relations course, emphasizing the World Wide Web. Outlines five course objectives, assignments and activities, evaluation, texts, and lecture topics. Argues that students mastering these course objectives will understand ethical issues relating to media use, using mediated technology in public…

Polyethylene Glycol Mediated Colorectal Cancer Chemoprevention: Roles of Epidermal Growth Factor Receptor and Snail

Science.gov (United States)

Wali, Ramesh K.; Kunte, Dhananjay P.; Koetsier, Jennifer L.; Bissonnette, Marc; Roy, Hemant K.

2008-01-01

Polyethylene glycol (PEG) is a clinically widely used agent with profound chemopreventive properties in experimental colon carcinogenesis. We previously reported that Snail/β-catenin signaling may mediate the suppression of epithelial proliferation by PEG, although the upstream events remain unclear. We report herein the role of epidermal growth factor receptor (EGFR), a known mediator of Snail and overepressed in ~80% of human colorectal cancers (CRC), on PEG-mediated anti-proliferative and hence anti-neoplastic effects in azoxymethane (AOM)-rats and HT-29 colon cancer cells. AOM-rats were randomized to either standard diet or one with 10% PEG 3350 and euthanized 8 weeks later. The colonic samples were subjected to immunohistochemical or Western blot analyses. PEG decreased mucosal EGFR by 60% (pPEG effects were obtained in HT-29 cells. PEG suppressed EGFR protein via lysosmal degradation with no change in mRNA levels. To show that EGFR antagonism per se was responsible for the antiproliferative effect, we inhibited EGFR by either pre-treating cells with gefitinib or stably transfecting with EGFR-shRNA and measured the effect of PEG on proliferation. In either case PEG effect was blunted suggesting a vital role of EGFR. Flow cytometric analysis revealed that EGFR-shRNA cells, besides having reduced membrane EGFR also expressed low Snail levels (40%), corroborating a strong association. Furthermore, in EGFR silenced cells PEG effect on EGFR or Snail was muted, similar to that on proliferation. In conclusion, we show that EGFR is the proximate membrane signaling molecule through which PEG initiates antiproliferative activity with Snail/β-catenin pathway playing the central intermediary function. PMID:18790788

Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail.

Science.gov (United States)

Wali, Ramesh K; Kunte, Dhananjay P; Koetsier, Jennifer L; Bissonnette, Marc; Roy, Hemant K

2008-09-01

Polyethylene glycol (PEG) is a clinically widely used agent with profound chemopreventive properties in experimental colon carcinogenesis. We reported previously that Snail/beta-catenin signaling may mediate the suppression of epithelial proliferation by PEG, although the upstream events remain unclear. We report herein the role of epidermal growth factor receptor (EGFR), a known mediator of Snail and overexpressed in approximately 80% of human colorectal cancers, on PEG-mediated antiproliferative and hence antineoplastic effects in azoxymethane (AOM) rats and HT-29 colon cancer cells. AOM rats were randomized to either standard diet or one with 10% PEG-3350 and euthanized 8 weeks later. The colonic samples were subjected to immunohistochemical or Western blot analyses. PEG decreased mucosal EGFR by 60% (P PEG effects were obtained in HT-29 cells. PEG suppressed EGFR protein via lysosmal degradation with no change in mRNA levels. To show that EGFR antagonism per se was responsible for the antiproliferative effect, we inhibited EGFR by either pretreating cells with gefitinib or stably transfecting with EGFR-short hairpin RNA and measured the effect of PEG on proliferation. In either case, PEG effect was blunted, suggesting a vital role of EGFR. Flow cytometric analysis revealed that EGFR-short hairpin RNA cells, besides having reduced membrane EGFR, also expressed low Snail levels (40%), corroborating a strong association. Furthermore, in EGFR silenced cells, PEG effect on EGFR or Snail was muted, similar to that on proliferation. In conclusion, we show that EGFR is the proximate membrane signaling molecule through which PEG initiates antiproliferative activity with Snail/beta-catenin pathway playing the central intermediary function.

The mediating role of emotional exhaustion in the relationship of mindfulness with turnover intentions and job performance

OpenAIRE

Reb, J; Narayanan, J; Chaturvedi, S; Ekkirala, S

2016-01-01

The role of mindfulness in the workplace has emerged as a legitimate and growing area of organizational scholarship. T he present research examined the role of employee emotional exhaustion in mediating the relationship of mindfulness with turnover intentions and task performance . Drawing on theory and empirical research on both organizational behavior and mindfulness, w e predicted that more mindful employees would show lower turnover intentions and higher task performance and that th e s e...

Impact of poly-victimization on mental health: the mediator and/or moderator role of self-esteem.

Science.gov (United States)

Soler, Laia; Kirchner, Teresa; Paretilla, Clàudia; Forns, Maria

2013-09-01

The current study examines the relationship between the total kinds of victimization (TKV) experienced, self-esteem, and internalizing symptoms (IS) and externalizing symptoms (ES). It also explores the mediator and/or moderator role of two self-esteem facets: self-liking (SL) and self-competence (SC). The sample comprised 736 adolescents recruited from eight secondary schools in Catalonia, Spain. The Rosenberg Self-Esteem Scale, the Youth Self Report, and the Juvenile Victimization Questionnaire were used to assess self-esteem facets (SL and SC), psychological distress (IS and ES), and the TKV suffered. This article has several innovative features. On one hand, it considers that self-esteem is comprised of two different but related factors: SL and SC. On the other hand, it is the first study to provide evidence for the mediator/moderator role of SL and SC between victimization and psychological symptoms, taking account of the TKV experienced. Results suggest that SL is more relevant to mental health than SC. A low sense of being a worthy social being (SL) is more closely related to both victimization and poor mental health than a low sense of personal efficacy (SC). Moreover, SL seems to partially mediate the relationship between TKV and both IS and ES, whereas SC only acts as a partial mediator for the TKV-IS relationship in girls. At the same time, SL acts as a partial moderator of the TKV-IS relationship in boys. These findings support the importance of self-esteem in buffering the impact of victimization on mental health and may indicate that proper prevention and treatment policies should focus on adolescents' sense of being a good person, according to their own criteria of worth.

The role of transportation technologies in reducing greenhouse gas emissions

International Nuclear Information System (INIS)

Anon.

1995-11-01

The potential role of passenger transportation technologies in reducing greenhouse gas emissions was discussed. The technologies considered in the report were those that affect ground transportation of passengers and were in at least the early stages of development in 1995. They were: (1) technologies to improve the fuel efficiency of cars and light trucks, (2) alternative fuels for internal combustion engines, (3) electric hybrid vehicles, (4) advanced technology transit buses, (5) intelligent transportation systems, (6) high speed rail, and (7) bicycles. For each option, the advantages and disadvantages were described. The feasibility of establishing a high-speed rail system serving Canada's most densely populated region, the Windsor to Quebec City corridor, was discussed. Economic and environmental studies of such a proposal are underway. tabs

Complex Mediation

DEFF Research Database (Denmark)

Bødker, Susanne; Andersen, Peter Bøgh

2005-01-01

This article has its starting point in a large number of empirical findings regarding computer-mediated work. These empirical findings have challenged our understanding of the role of mediation in such work; on the one hand as an aspect of communication and cooperation at work and on the other hand...... as an aspect of human engagement with instruments of work. On the basis of previous work in activity-theoretical and semiotic human—computer interaction, we propose a model to encompass both of these aspects. In a dialogue with our empirical findings we move on to propose a number of types of mediation...... that have helped to enrich our understanding of mediated work and the design of computer mediation for such work....

Ethnic and Racial Socialization and Self-Esteem of Asian Adoptees: The Mediating Role of Multiple Identities

Science.gov (United States)

Mohanty, Jayashree

2013-01-01

Positive identity development during adolescence in general is a complex process and may pose additional challenges for adolescents adopted from a different culture. Using a web-based survey design with a sample of 100 internationally adopted Asian adolescent and young adults, the present study examined the mediating role of multiple identities…

Parental mediation, online activities, and cyberbullying.

Science.gov (United States)

Mesch, Gustavo S

2009-08-01

Cyberbullying, the use of information and communication technologies to intentionally harm others, has become an important area of research. Studies have begun to investigate the extent of cyberbullying and its victims' personality characteristics. Less is known about the effect of specific online activities and the role of parental mediation on the likelihood of being bullied. This study attempts to fill this gap in the literature conducting a secondary analysis of a representative sample of the U.S. youth population, the Teens and Parents survey conducted by the Pew and American Life Project (n = 935). The results indicate that the risk of youth being bullied is higher for adolescents who have an active profile on social networking sites and participate in chat rooms but not in playing games online. Gender differences emerge in risk factors. A few parental mediation techniques are protective, but most are not. The results indicate the need for more parental participation to reduce risks to youth arising from Internet use for interpersonal communication.

Employment Status and Mental Health: Mediating Roles of Social Support and Coping Strategies.

Science.gov (United States)

Perreault, Michel; Touré, El Hadj; Perreault, Nicole; Caron, Jean

2017-09-01

Although it has been established that unemployment and underemployment increase distress and depression, the psychological mechanisms involved are not very clear. This study examines the roles of social support and coping strategies as mediators of the association between employment status and mental health, as well as gender and age differences as moderators. Residents from the epidemiological catchment area of south-west Montreal responded to a randomized household survey for adults in 2009. A follow-up was conducted based on participants' employment status 2 and 4 years later. ANOVAs tests were computed with SPSS to evaluate group differences, and structural equation modeling was performed with AMOS to test mediation effects. At baseline, among participants between 18 and 64 years old (n = 2325), 14.3 % were unemployed/not studying, 14.4 % worked part-time, and 56.5 % worked full-time. Employment status was found to significantly affect depression among those under 45 years old (chi-square = 23.4, p employment with depression, which was fully mediated by social support, less coping with drugs/medication, and less distress. A negative association with full-time employment was also noted with distress, which was partially mediated by increased social support, coping with alcohol, and less coping with drugs/medication. The total indirect effect suggests that full-time employees generally have more resources and do not tend to use avoidance strategies like coping with drugs/medication, resulting in less distress (β = -0.05; p employment, namely full-time employment, in communities.

The fostering role of information technology on SMEs' strategic ...

African Journals Online (AJOL)

Scholarly concerns about the fostering role of information technology (IT) in supply chain management have increased dramatically over the past decades. Nevertheless, there are significant issues yet to be addressed and resolved, one of which relates to the influences of IT on strategic purchasing, logistics integration and ...

How Might Civilian Technology Firms Play A Role In The Defense Industrial Base Going Forward

Science.gov (United States)

2017-12-01

CIVILIAN TECHNOLOGY FIRMS PLAY A ROLE IN THE DEFENSE INDUSTRIAL BASE GOING FORWARD? by Daniel J. Shipman December 2017 Thesis Advisor: Mie...2017 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE HOW MIGHT CIVILIAN TECHNOLOGY FIRMS PLAY A ROLE IN THE DEFENSE INDUSTRIAL...the competitive business environment of Department of Defense (DOD) vendors and whether the market is favorable for non-traditional, technology

Transformational leadership and group potency in small military units: The mediating role of group identification and cohesion

Directory of Open Access Journals (Sweden)

Carlos García-Guiu

2016-12-01

Full Text Available In the present study, we examined an exploratory model to assess the relationship between transformational leadership and group potency and analyze the mediating role of group identification and cohesion. The research was conducted with squads of the Spanish Army. The sample was composed of 243 members of 51 squads of operational units. Our findings highlighted the importance of the transformational leadership style of command of non-commissioned officers (NCOs due to its positive relationship with the group potency of the squad. We also analyzed the indirect relationships between transformational leadership and group identification and group cohesion and found that the latter variables played a mediating role between transformational leadership and group potency. The conclusions of this study are relevant due to the growing importance of transformational leadership and actions implemented at lower levels of the command chain for the success of missions of security organizations and defense.

The Role of Science and Technology in the Advancement of Women Worldwide

Energy Technology Data Exchange (ETDEWEB)

Hays, I.; Farhar, B.

2000-10-12

Participants at the 1995 Fourth World Conference on Women, held in Beijing, China, created a Platform for Action focusing on 12 critical areas of concern (poverty, education and training, health, violence, armed conflict, economy, decision-making, institutional mechanisms, human rights, the media, environment, and the girl child) and the serious barriers to women's health and well-being in each area. Subsequently, the Department of Energy funded a study, described here, that shows, in a literature review and in interviews with 15 women experts, how science and technology can be integral to women's advancement in each of the 12 critical areas. Among the study's conclusions are that differing perspectives exist (pro-science, relativist, and skeptical) on the role of science and technology in women's lives and that these differing perspectives may explain why communication is difficult among policy makers and with scientists about the role science and technology may play in the advancem ent of women worldwide. Recommendations call for women's involvement in the ethics of science; removal of institutional barriers to advancing women; greater accountability in use of resources; changes in science education; and increased dialogue among those with differing perspectives on the role of science and technology in the advancement of women.

Reality check: the role of realism in stress reduction using media technology.

Science.gov (United States)

de Kort, Y A W; Ijsselsteijn, W A

2006-04-01

There is a growing interest in the use of virtual and other mediated environments for therapeutic purposes. However, in the domain of restorative environments, virtual reality (VR) technology has hardly been used. Here the tendency has been to use mediated real environments, striving for maximum visual realism. This use of photographic material is mainly based on research in aesthetics judgments that has demonstrated the validity of this type of simulations as representations of real environments. Thus, restoration therapy is developing under the untested assumption that photorealistic images have the optimal level of realism, while in therapeutic applications 'experiential realism' seems to be the key rather than visual realism. The present paper discusses this contrast and briefly describes data of three studies aimed at exploring the importance and meaning of realism in the context of restorative environments.

The role of incoherent microRNA-mediated feedforward loops in noise buffering.

Directory of Open Access Journals (Sweden)

Matteo Osella

2011-03-01

Full Text Available MicroRNAs are endogenous non-coding RNAs which negatively regulate the expression of protein-coding genes in plants and animals. They are known to play an important role in several biological processes and, together with transcription factors, form a complex and highly interconnected regulatory network. Looking at the structure of this network, it is possible to recognize a few overrepresented motifs which are expected to perform important elementary regulatory functions. Among them, a special role is played by the microRNA-mediated feedforward loop in which a master transcription factor regulates a microRNA and, together with it, a set of target genes. In this paper we show analytically and through simulations that the incoherent version of this motif can couple the fine-tuning of a target protein level with an efficient noise control, thus conferring precision and stability to the overall gene expression program, especially in the presence of fluctuations in upstream regulators. Among the other results, a nontrivial prediction of our model is that the optimal attenuation of fluctuations coincides with a modest repression of the target expression. This feature is coherent with the expected fine-tuning function and in agreement with experimental observations of the actual impact of a wide class of microRNAs on the protein output of their targets. Finally, we describe the impact on noise-buffering efficiency of the cross-talk between microRNA targets that can naturally arise if the microRNA-mediated circuit is not considered as isolated, but embedded in a larger network of regulations.

Effects of role stress on nurses' turnover intentions: The mediating effects of organizational commitment and burnout.

Science.gov (United States)

Han, Sang-Sook; Han, Jeong-Won; An, Young-Suk; Lim, So-Hee

2015-10-01

This paper was designed to extend the extant research regarding factors related to nurses' turnover intentions. This survey-based study was based on a path analysis designed to verify a hypothesized causal model involving nurses' role stress, organizational commitment, turnover intentions, and burnout. This study distributed 500 questionnaires to nurses in general hospitals with more than 500 beds located in Seoul, Korea, during 16-30 April 2012. Role conflict, an underlying factor in role stress, had no significant effect on role stress, but the results showed that role ambiguity reduced organizational commitment. On the other hand, role conflict and role ambiguity increased the level of burnout. Organizational commitment reduced turnover intentions, and burnout increased turnover intentions. Role conflict and role ambiguity had no direct effect on turnover intentions, but they had indirect effects on organizational commitment and burnout. To reduce nurses' turnover rate, this study recommends developing plans to improve their organizational commitment because it mediates role stress and turnover intention. © 2014 The Authors. Japan Journal of Nursing Science © 2014 Japan Academy of Nursing Science.

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression

Directory of Open Access Journals (Sweden)

Roopa Thapar

2015-05-01

Full Text Available The peptidyl-prolyl cis-trans isomerases (PPIases that include immunophilins (cyclophilins and FKBPs and parvulins (Pin1, Par14, Par17 participate in cell signaling, transcription, pre-mRNA processing and mRNA decay. The human genome encodes 19 cyclophilins, 18 FKBPs and three parvulins. Immunophilins are receptors for the immunosuppressive drugs cyclosporin A, FK506, and rapamycin that are used in organ transplantation. Pin1 has also been targeted in the treatment of Alzheimer’s disease, asthma, and a number of cancers. While these PPIases are characterized as molecular chaperones, they also act in a nonchaperone manner to promote protein-protein interactions using surfaces outside their active sites. The immunosuppressive drugs act by a gain-of-function mechanism by promoting protein-protein interactions in vivo. Several immunophilins have been identified as components of the spliceosome and are essential for alternative splicing. Pin1 plays roles in transcription and RNA processing by catalyzing conformational changes in the RNA Pol II C-terminal domain. Pin1 also binds several RNA binding proteins such as AUF1, KSRP, HuR, and SLBP that regulate mRNA decay by remodeling mRNP complexes. The functions of ribonucleoprotein associated PPIases are largely unknown. This review highlights PPIases that play roles in RNA-mediated gene expression, providing insight into their structures, functions and mechanisms of action in mRNP remodeling in vivo.

Pathological narcissism and depressive symptoms in psychiatric outpatients: mediating role of dysfunctional attitudes.

Science.gov (United States)

Marčinko, Darko; Jakšić, Nenad; Ivezić, Ena; Skočić, Milena; Surányi, Zsuzsanna; Lončar, Mladen; Franić, Tomislav; Jakovljević, Miro

2014-04-01

The aim of this study was to examine the relationships between pathological narcissism (narcissistic grandiosity and narcissistic vulnerability), dysfunctional attitudes (perfectionism and dependency on other people), and depressive symptoms in psychiatric outpatients. A sample of 234 adult psychiatric outpatients (57.3% male; mean age 44.39 years) completed the Pathological Narcissism Inventory, the Dysfunctional Attitudes Scale-Form A, and the Depression, Anxiety, Stress Scales-21. Narcissistic vulnerability exhibited unique positive correlations with depressive symptoms, whereas narcissistic grandiosity showed substantially weaker correlations with depressive symptoms. Perfectionism partially mediated the relationship between narcissistic vulnerability and depressive symptoms. The mediating role of dependency was not confirmed. Among adult psychiatric outpatients, narcissistic vulnerability is more strongly related to depressive symptoms than narcissistic grandiosity, and dysfunctional perfectionism represents one of the underlying mechanisms of this relationship. The implications of these findings are discussed in relation to the Diagnostic and Statistical Manual of Mental Disorders diagnostic criteria and the treatment of pathological narcissism. © 2013 Wiley Periodicals, Inc.

Negative Interpersonal Interactions and Dating Abuse Perpetration: The Mediating Role of Dispositional Forgivingness.

Science.gov (United States)

Garthe, Rachel C; Griffin, Brandon J; Worthington, Everett L; Goncy, Elizabeth A; Sullivan, Terri N; Coleman, Jennifer A; Davis, Don E; Kwakye-Nuako, Charlotte O; Mokushane, Thapelo; Makola, Solomon; Anakwah, Nkansah

2017-06-01

Theory and research suggest that an individual's negative interactions with his or her parents or romantic partner are associated with the perpetration of dating abuse. Research is beginning to explore the role of forgivingness within abusive romantic relationships, and these preliminary findings suggest that dispositional forgivingness might mediate the relations between negative interpersonal interactions and dating abuse. The current study assessed negative interactions with one's parents and one's romantic partner, the frequency of dating abuse perpetration, and dispositional forgivingness of others and oneself among a sample of emerging adults in college ( n = 421). Dispositional forgivingness of others was negatively associated with the perpetration of emotional/verbal dating abuse and threatening behaviors, and it mediated relations between negative interpersonal interactions and dating abuse perpetration. Our findings suggest that the tendency to forgive others may explain why some individuals who experience negative interpersonal interactions with parents or romantic partners do not escalate to perpetration of abuse within their romantic relationships. Implications for future research and application are discussed.

Determinants of compulsive buying behavior among young adults: The mediating role of materialism.

Science.gov (United States)

Islam, Tahir; Wei, Jiuchang; Sheikh, Zaryab; Hameed, Zahid; Azam, Rauf I

2017-12-01

This research seeks to determine what makes young adults materialistic. The study examines the mediating role of materialism between the contextual factors and compulsive buying. Data was gathered from 219 Pakistani undergraduate university students. Partial Least Square (PLS) technique was used to analyze the data. The study confirms the intuition that more materialistic young adults are more likely to be involved in compulsive buying than are less materialistic young adults. The results were similar with the previous literature conducted in the western culture, indicating that also applies in a modern Islamic society. The findings of the study reveal that materialism mediated the relationship between certain sociological factors (i.e., group, media Celebrity endorsement, and TV advertisement) and compulsive buying. The study highlights the importance of understanding young adults' materialistic attitudes and consumption decisions and provides key knowledge for researchers, policymakers, and managers of leading brands. Copyright © 2017. Published by Elsevier Ltd.

Physician's emerging roles relating to trends in health information technology.

Science.gov (United States)

David Johnson, J

2014-08-12

Objective: To determine the new roles that physicians will adopt in the near future to adjust to accelerating trends from managed care to outcome-based practice to health care reform to health information technology to the evolving role of health consumers. Methods: Trends and related developments concerning the changing roles of physicians based on prior literature reviews. Results: Six possible roles, traditional, gatekeeper, coach, navigator, informatician and one voice among many, are discussed in terms of physician's centrality, patient autonomy, decision-making and uncertainty, information seeking, satisfaction and outcomes, particularly those related to compliance. Conclusion: A greater understanding of these emerging roles could lead to more efficacious outcomes in our ever changing, increasingly complex medical system. Patients often have little understanding of emerging trends that lead to the development of specialized roles such as hospitalist and navigators and, relatedly, the evolving roles of physicians.

Social networking sites and mental health problems in adolescents: The mediating role of cyberbullying victimization.

Science.gov (United States)

Sampasa-Kanyinga, H; Hamilton, H A

2015-11-01

Previous research has suggested an association between the use of social networking sites (SNSs) and mental health problems such as psychological distress, suicidal ideation and attempts in adolescents. However, little is known about the factors that might mediate these relationships. The present study examined the link between the use of social networking sites and psychological distress, suicidal ideation and suicide attempts, and tested the mediating role of cyberbullying victimization on these associations in adolescents. The sample consisted of a group of 11-to-20-year-old individuals (n=5126, 48% females; mean±SD age: 15.2±1.9 years) who completed the mental health portion of the Ontario Student Drug Use and Health Survey (OSDUHS) in 2013. Multiple logistic regression analyses were used to test the mediation models. After adjustment for age, sex, ethnicity, subjective socioeconomic status (SES), and parental education, use of SNSs was associated with psychological distress (adjusted odds ratio, 95% confidence interval=2.03, 1.22-3.37), suicidal ideation (3.44, 1.54-7.66) and attempts (5.10, 1.45-17.88). Cyberbullying victimization was found to fully mediate the relationships between the use of SNSs with psychological distress and attempts; whereas, it partially mediated the link between the use of SNSs and suicidal ideation. Findings provide supporting evidence that addressing cyberbullying victimization and the use of SNSs among adolescents may help reduce the risk of mental health problems. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Diffusion of medical technology: the role of financing.

Science.gov (United States)

Cappellaro, Giulia; Ghislandi, Simone; Anessi-Pessina, Eugenio

2011-04-01

In the last decade the pace of innovation in medical technology has accelerated: hence the need to better identify and understand the real forces behind the adoption and diffusion of medical technology innovations in clinical practice. Among these forces, financial incentives may be expected to play a major role. The purpose of this paper was to assess the influence of financing mechanisms for new medical devices and correlated procedures on their diffusion. The analysis was carried out in the Italian inpatient cardiovascular area and applied to drug eluting stents over the period 2003-07. The paper's main hypothesis, that higher levels of reimbursement encourage technology diffusion, was rejected. So was the hypothesis that private hospitals may be more sensitive to tariff levels than public hospitals. A statistically significant difference was found only between hospitals that are funded on a Diagnosis-Related Groups (DRGs) basis and those that are not, with the former showing higher levels of technology diffusion. These results warn policy makers against excessive reliance on specific reimbursement fee changes as a way of steering provider behaviour. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

E-Commerce Audit Judgment Expertise: Does Expertise in System Change Management and Information Technology Auditing Mediate E-Commerce Audit Judgment Expertise?

Directory of Open Access Journals (Sweden)

Jagdish PATHAK

2010-01-01

Full Text Available A global survey of 203 E-commerce auditors was conducted to investigate the perceptions about the potential determinants of expertise in E-commerce audits. We hypothesize and find evidence indicating that information technology and communication expertise are positively related to expertise in E-commerce audit judgment. We also find that system change management expertise and information technology audit expertise mediate this relationship.

The Role of Social Factors in Shaping Students' Test Emotions: A Mediation Analysis of Cognitive Appraisals

Science.gov (United States)

Buric, Irena

2015-01-01

The aim of this study was to examine the relationships between test emotions and their proximal and distal antecedents in the math domain as proposed by the control-value theory of achievement emotions, using structural equation modeling. More specifically, it investigates the mediating role of cognitive appraisals of control and value in the…

Hostility and hearing protection behavior: the mediating role of personal beliefs and low frustration tolerance.

Science.gov (United States)

Rabinowitz, S; Melamed, S; Feiner, M; Weisberg, E; Ribak, J

1996-10-01

The authors examined whether hostility would negatively be associated with occupational health behavior, namely, the use of hearing protection devices (HPDs). Also examined as possible mediators were the protection motivation theory (PMT) components and low frustration tolerance (LFT). Participants were 226 male industrial workers, all exposed to potentially hearing-damaging noise. Hostility was negatively related to HPD use. It moderately correlated with the PMT components: negatively with perceived susceptibility, severity, effectiveness, and self-efficacy and positively with perceived barriers. Hostility correlated highly with LFT. Regression analyses confirmed the mediating role of perceived barriers, low self-efficacy, and LFT in the negative relationship between hostility and the use of HPDs. Thus, intrapsychic characteristics of hostile people may be significant for hearing protection behavior.

Nurse turnover: the mediating role of burnout.

Science.gov (United States)

Leiter, Michael P; Maslach, Christina

2009-04-01

This study tested whether the mediation model of burnout could predict nurses' turnover intentions. A better understanding of what factors support a commitment to a nursing career could inform both policies and workplace practices. The mediation model of burnout provides a way of linking the quality of a nurse's worklife to various outcomes, such as turnover. Data on areas of worklife, burnout, and turnover intentions were collected by surveying 667 Canadian nurses in the Atlantic Provinces. The findings supported the mediation model of burnout, in which areas of worklife predicted burnout, which in turn predicted turnover intentions. Cynicism was the key burnout dimension for turnover, and the most critical areas of worklife were value conflicts and inadequate rewards. The results of this study provide some new insights into how the intention of nurses to leave their job is related to particular aspects of their worklife and to burnout. These results suggest what may be the most appropriate areas to target for interventions to reduce the risk of nurses exiting early from their chosen career.

The role of computer simulation in nuclear technologies development

International Nuclear Information System (INIS)

Tikhonchev, M.Yu.; Shimansky, G.A.; Lebedeva, E.E.; Lichadeev, V. V.; Ryazanov, D.K.; Tellin, A.I.

2001-01-01

In the report the role and purposes of computer simulation in nuclear technologies development is discussed. The authors consider such applications of computer simulation as nuclear safety researches, optimization of technical and economic parameters of acting nuclear plant, planning and support of reactor experiments, research and design new devices and technologies, design and development of 'simulators' for operating personnel training. Among marked applications the following aspects of computer simulation are discussed in the report: neutron-physical, thermal and hydrodynamics models, simulation of isotope structure change and damage dose accumulation for materials under irradiation, simulation of reactor control structures. (authors)

Technological progress, safety, and the guardian role of inspection

Energy Technology Data Exchange (ETDEWEB)

Critchley, O H

1981-08-01

Technological innovation is accompanied by unforeseen human consequences as well as benefits, and progress has produced a public awareness of the potential for hazards that has led to efficient safety-inspection procedures. Because no safety procedure is foolproof, the public learns to tolerate certain levels of risk from technology if it concludes that the benefits are worthwhile. The perception of values often transcends simple cost/benefit analysis. Safety technology and regulation developed during the past 50 years has benefited from earlier disastrous accidents enough to give the nuclear power industry an unprecedented safety record. Efforts to understand and anticipate human error have refined the role of inspection without achieving absolute reliability. Well-directed inspections that accept human fallibility will achieve more than design and organizational improvements. 42 references. (DCK)

The Role of Mobile Technologies in Pre-Service Foreign Language Teacher Education

Science.gov (United States)

Tolosa, Constanza

2017-01-01

Pre-service teacher education plays a pivotal role in ensuring that future teachers are prepared to integrate technology effectively to their teaching. One way of improving readiness in future teachers is integrating mobile technologies to discipline-specific teacher education courses. This article presents three case studies drawn from…

POSTPARTUM BONDING DIFFICULTIES AND ADULT ATTACHMENT STYLES: THE MEDIATING ROLE OF POSTPARTUM DEPRESSION AND CHILDBIRTH-RELATED PTSD.

Science.gov (United States)

S Hairston, Ilana; E Handelzalts, Jonathan; Assis, Chen; Kovo, Michal

2018-03-01

Despite decades of research demonstrating the role of adult attachment styles and early mother-infant bonding in parenting behaviors and maternal mental health, these constructs have seldom been studied together. The present study aimed to investigate the relationship between attachment styles and specific bonding difficulties of mothers. In addition, as postpartum depression and childbirth-related posttraumatic stress symptoms have been associated with both constructs, we explored their possible mediation effect. One hundred fourteen mothers, 4 to 12 weeks' postpartum, completed a demographic questionnaire, the Adult Attachment Style Questionnaire (M. Mikulincer, V. Florian, & A. Tolmacz, 1990), the Postpartum Bonding Questionnaire (L.F. Brockington, C. Fraser, & D. Wilson, 2006), the Modified Perinatal Posttraumatic Stress Disorder Questionnaire (J.L. Callahan, S.E. Borja, & M.T. Hynan, 2006), and the Edinburgh Postnatal Depression Scale (J.L. Cox, G. Chapman, D. Murray, & P. Jones, 1996), using an online survey system. As predicted, insecure attachment styles were associated with bonding difficulties wherein anxious/ambivalent attachment was associated with greater infant-focused anxiety, mediated by postpartum depression but not childbirth-related PTSD symptoms. In contrast, greater avoidant attachment style was associated with greater rejection and anger, mediated by childbirth-related posttraumatic stress disorder (PTSD), but not depression symptoms. The current study confirmed the association of different attachment styles with bonding as well as the mediating roles of childbirth-related PTSD and postpartum depression symptoms. Future psychological interventions may utilize such evidence to target interventions for bonding disorders in accordance with individual differences. © 2018 Michigan Association for Infant Mental Health.

Insecure attachment is associated with paranoia but not hallucinations in psychotic patients: the mediating role of negative self-esteem.

Science.gov (United States)

Wickham, S; Sitko, K; Bentall, R P

2015-05-01

A growing body of research has investigated associations between insecure attachment styles and psychosis. However, despite good theoretical and epidemiological reasons for hypothesising that insecure attachment may be specifically implicated in paranoid delusions, few studies have considered the role it plays in specific symptoms. We examined the relationship between attachment style, paranoid beliefs and hallucinatory experiences in a sample of 176 people with a diagnosis of schizophrenia spectrum disorders and 113 healthy controls. We also investigated the possible role of negative self-esteem in mediating this association. Insecure attachment predicted paranoia but not hallucinations after co-morbidity between the symptoms was controlled for. Negative self-esteem partially mediated the association between attachment anxiety and clinical paranoia, and fully mediated the relationship between attachment avoidance and clinical paranoia. It may be fruitful to explore attachment representations in psychological treatments for paranoid patients. If future research confirms the importance of disrupted attachment as a risk factor for persecutory delusions, consideration might be given to how to protect vulnerable young people, for example those raised in children's homes.

A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1.

Directory of Open Access Journals (Sweden)

Karen M Chisholm

Full Text Available Alu-mediated rearrangement of tumor suppressor genes occurs frequently during carcinogenesis. In breast cancer, this mechanism contributes to loss of the wild-type BRCA1 allele in inherited disease and to loss of heterozygosity in sporadic cancer. To identify genes required for suppression of Alu-mediated recombination we performed a genomewide screen of a collection of 4672 yeast gene deletion mutants using a direct repeat recombination assay. The primary screen and subsequent analysis identified 12 candidate genes including TSA, ELG1, and RRM3, which are known to play a significant role in maintaining genomic stability. Genetic analysis of the corresponding human homologs was performed in sporadic breast tumors and in inherited BRCA1-associated carcinomas. Sequencing of these genes in high risk breast cancer families revealed a potential role for the helicase PIF1 in cancer predisposition. PIF1 variant L319P was identified in three breast cancer families; importantly, this variant, which is predicted to be functionally damaging, was not identified in a large series of controls nor has it been reported in either dbSNP or the 1000 Genomes Project. In Schizosaccharomyces pombe, Pfh1 is required to maintain both mitochondrial and nuclear genomic integrity. Functional studies in yeast of human PIF1 L319P revealed that this variant cannot complement the essential functions of Pfh1 in either the nucleus or mitochondria. Our results provide a global view of nonessential genes involved in suppressing Alu-mediated recombination and implicate variation in PIF1 in breast cancer predisposition.

Agentic and communal narcissism and satisfaction with life: The mediating role of psychological entitlement and self-esteem.

Science.gov (United States)

Żemojtel-Piotrowska, Magdalena A; Piotrowski, Jarosław P; Maltby, John

2017-10-01

This study examined the mediational role of self-esteem (as an enhancement) and psychological entitlement (as a cost) in the relationship between an agentic-communal model of grandiose narcissism and satisfaction with life. Two hundred and forty-eight university undergraduate students completed measures of agentic and communal narcissism, self-esteem, psychological entitlement and satisfaction with life. The findings suggest that there is support for the usefulness of the agentic-communal model of narcissism, and, consistent with predictions in the wider literature, self-esteem and psychological entitlement mediated the relationship between agentic-communal narcissism and life satisfaction. © 2015 International Union of Psychological Science.

Delineating the Maladaptive Pathways of Child Maltreatment: A Mediated Moderation Analysis of the Roles of Self Perception and Social Support

Science.gov (United States)

Appleyard, Karen; Yang, Chongming; Runyan, Desmond K.

2014-01-01

The current study investigated concurrent and longitudinal mediated and mediated moderation pathways among maltreatment, self perception (i.e., loneliness and self esteem), social support, and internalizing and externalizing behavior problems. For both genders, early childhood maltreatment (i.e., ages 0–6) was related directly to internalizing and externalizing behavior problems at age 6, and later maltreatment (i.e., ages 6–8) was directly related to internalizing and externalizing behavior problems at age 8. Results of concurrent mediation and mediated moderation indicated that early maltreatment was significantly related to internalizing and externalizing behavior problems at age 6 indirectly both through age 6 loneliness and self esteem for boys and through age 6 loneliness for girls. Significant moderation of the pathway from early maltreatment to self esteem, and, for boys, significant mediated moderation to emotional and behavioral problems were found, such that the mediated effect through self esteem varied across levels of social support, though in an unexpected direction. No significant longitudinal mediation or mediated moderation was found, however, between the age 6 mediators and moderator and internalizing or externalizing problems at age 8. The roles of the hypothesized mediating and moderating mechanisms are discussed, with implications for designing intervention and prevention programs. PMID:20423545

Delineating the maladaptive pathways of child maltreatment: a mediated moderation analysis of the roles of self-perception and social support.

Science.gov (United States)

Appleyard, Karen; Yang, Chongming; Runyan, Desmond K

2010-05-01

The current study investigated concurrent and longitudinal mediated and mediated moderation pathways among maltreatment, self-perception (i.e., loneliness and self-esteem), social support, and internalizing and externalizing behavior problems. For both genders, early childhood maltreatment (i.e., ages 0-6) was related directly to internalizing and externalizing behavior problems at age 6, and later maltreatment (i.e., ages 6-8) was directly related to internalizing and externalizing behavior problems at age 8. Results of concurrent mediation and mediated moderation indicated that early maltreatment was significantly related to internalizing and externalizing behavior problems at age 6 indirectly both through age 6 loneliness and self-esteem for boys and through age 6 loneliness for girls. Significant moderation of the pathway from early maltreatment to self-esteem, and for boys, significant mediated moderation to emotional and behavioral problems were found, such that the mediated effect through self-esteem varied across levels of social support, though in an unexpected direction. No significant longitudinal mediation or mediated moderation was found, however, between the age 6 mediators and moderator and internalizing or externalizing problems at age 8. The roles of the hypothesized mediating and moderating mechanisms are discussed, with implications for designing intervention and prevention programs.

Long-term care services and support systems for older adults: The role of technology.

Science.gov (United States)

Czaja, Sara J

2016-01-01

The aging of the population, especially the increase in the "oldest old," is a remarkable achievement that presents both opportunities and challenges for policymakers, researchers, and society. Although many older adults enjoy relatively good health into their later years, many have one or more chronic conditions or diseases and need help with disease management activities or activities important to independent living. Technology is playing an increasingly important role in the health care arena and is becoming ubiquitous in health management activities. There are a variety of technology applications that can be used to enhance the mobility and quality of life of people who have limitations and help to foster the ability of those with chronic conditions to remain at home. Technology applications can also provide a central role in providing support to family caregivers in terms of enhancing access to information and community resources and connections to formal and informal support services. Monitoring technologies may also allow caregivers to check on the status or activities of their loved one while they are at work or at a distant location. Furthermore, telemedicine applications can aid the ability of care providers to monitor patients and deliver health services. The objective of this article is to highlight the potential role that technology can play in the provision of long-term support for older adults and their families. Challenges and barriers that currently limit the full potential of technology to be realized for these populations will also be discussed. Finally the role of psychological science toward maximizing the potential of technology applications in enhancing long term care and support services will be highlighted. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Gratitude and Adolescents' Subjective Well-Being in School: The Multiple Mediating Roles of Basic Psychological Needs Satisfaction at School.

Science.gov (United States)

Tian, Lili; Pi, Luyang; Huebner, E S; Du, Minmin

2016-01-01

Based on the relation between gratitude and general subjective well-being (SWB), and Basic Psychological Needs Theory (Ryan and Deci, 2000), the present study's aim was to use structural equation modeling to test the multiple mediational roles of the satisfaction of three basic psychological needs at school in accounting for the association between gratitude and SWB in school (school satisfaction, school affect) in adolescents. A total of 881 Chinese adolescents (427 males; Mean age = 12.97) completed a multi-measure questionnaire that tapped the targeted variables. Findings revealed that gratitude related significantly, positively to adolescents' SWB in school. Moreover, a multiple-mediators analysis suggested that relatedness and competence needs satisfaction at school mediated the relation between gratitude and SWB in school. Lastly, a multiple-mediators analysis also indicated that autonomy needs satisfaction mediated the relation between relatedness and competence needs and SWB in school. Limitations and practical applications of the study were discussed.

Gratitude and Adolescents’ Subjective Well-Being in School: The Multiple Mediating Roles of Basic Psychological Needs Satisfaction at School

Science.gov (United States)

Tian, Lili; Pi, Luyang; Huebner, E. S.; Du, Minmin

2016-01-01

Based on the relation between gratitude and general subjective well-being (SWB), and Basic Psychological Needs Theory (Ryan and Deci, 2000), the present study’s aim was to use structural equation modeling to test the multiple mediational roles of the satisfaction of three basic psychological needs at school in accounting for the association between gratitude and SWB in school (school satisfaction, school affect) in adolescents. A total of 881 Chinese adolescents (427 males; Mean age = 12.97) completed a multi-measure questionnaire that tapped the targeted variables. Findings revealed that gratitude related significantly, positively to adolescents’ SWB in school. Moreover, a multiple-mediators analysis suggested that relatedness and competence needs satisfaction at school mediated the relation between gratitude and SWB in school. Lastly, a multiple-mediators analysis also indicated that autonomy needs satisfaction mediated the relation between relatedness and competence needs and SWB in school. Limitations and practical applications of the study were discussed. PMID:27708601

Roles Prioritization of Hydrogen Production Technologies for Promoting Hydrogen Economy in the Current State of China

DEFF Research Database (Denmark)

Ren, Jingzheng; Gao, Suzhao; Tan, Shiyu

2015-01-01

Hydrogen production technologies play an important role in the hydrogen economy of China. However, the roles of different technologies played in promoting the development of hydrogen economy are different. The role prioritization of various hydrogen production technologies is of vital importance...... information. The prioritization results by using the proposed method demonstrated that the technologies of coal gasification with CO2 capture and storage and hydropower-based water electrolysis were regarded as the two most important hydrogen production pathways for promoting the development of hydrogen...... for the stakeholders/decision-makers to plan the development of hydrogen economy in China and to allocate the finite R&D budget reasonably. In this study, DPSIR framework was firstly used to identify the key factors concerning the priorities of various hydrogen production technologies; then, a fuzzy group decision...

[The mediating role of organizational citizenship behavior between organizational justice and organizational effectiveness in nursing organizations].

Science.gov (United States)

Park, Wall Yun; Yoon, Sook Hee

2009-04-01

This study was a secondary analysis to verify the mediating role of organizational citizenship behavior (OCB) between organizational justice (OJ) and organizational effectiveness (OE) in nursing organizations. The RN-BSNs and their colleagues in Seoul and Busan were subjects. The data was collected for 20 days between September 13 and October 2, 2004. Two hundred eighty three data sets were used for the final analysis. The fitness of models were tested using AMOS 5. The fitness of hypothetical model was moderate. Procedural Justice (PJ), Interaction Justice (IJ) and Distributive Justice (DJ) had direct effects on Job Satisfaction (JS), Organizational Commitment (OC) and Turnover Intention (TI) in OE, and indirect effects on JS, OC and TI mediated by OCB. The modified model improved with ideal fitness showed the causal relations among OE. In modified model, PJ, IJ and DJ had direct positive effects on OCB and JS and OC in OE, and indirect effects on JS and OC mediated by OCB. JS and OC in OE had a direct negative effect on TI. OCB mediated the relationship between OJ and OE, so the nursing managers should enhance OCB of the nurses in order to improve OE.

The Role of the Technology Supplier in the Politics of Production

DEFF Research Database (Denmark)

Koch, Christian

1996-01-01

from a multitude of positions outside the factory. This includes the impacts through formation of subjectivity, labour market, social security, the origin of rawmateriel, ie.the production chains, and the technology used in the factory. On the basis of a Danish study the role of the technology supplier......This paper examines the relations between the technology supplier and the customer factory as an element of the politics of production. It is initially argued that labour process theory cannot limit itself to the analysis of individual enterprises. The politics in production is actually impacted...

The role of pragmatics in mediating the relationship between social disadvantage and adolescent behavior.

Science.gov (United States)

Law, James; Rush, Robert; Clegg, Judy; Peters, Tim; Roulstone, Susan

2015-06-01

The relationship between social disadvantage, behavior, and communication in childhood is well established. Less is known about how these 3 interact across childhood and specifically whether pragmatic language skills act as a mediator between early social disadvantage and adolescent behavior. The sample was the Avon Longitudinal Study of Parents and Children, a representative birth cohort initially recruited in England in 1991/1992 and followed through to adolescence and beyond. Of the original 13,992 live births, data were available for 2926 children at 13 years. Univariable analysis was first used to identify sociodemographic and other predictors of the Strengths and Difficulties Questionnaire (SDQ) at 13 years. The mediational role of the pragmatics scale of the Children's Communication Checklist (CCC) at 9 years was then tested, controlling for age, gender, and IQ. There was evidence of both a direct effect from social disadvantage (path C') to SDQ Total Behavior Score at 13 years (-.205; p pragmatics scale as a mediator. The latter represents a reduction in the magnitude of the unadjusted effect or "total effect" (-.430), demonstrating that the pragmatics scale partially mediates the relationship of early social disadvantage and adolescent behavior (even after controlling for other covariates). The same relationship held for all but the pro-social subscale of the SDQ. The results provide evidence to suggest that there maybe a causal relationship between these variables, suggesting that interventions targeting pragmatic skills have the potential to reduce adolescent behavioral symptoms.

Impact of role models in business creation, mediators and gender effects; Incidencia de los modelos de referencia en la creacion de empresas. Efectos mediadores y de genero

Energy Technology Data Exchange (ETDEWEB)

Justo, R.; Diaz, C.

2012-11-01

Knowing other entrepreneurs contributes to the success of start-ups, serving among others as role models. We argue that this relationship may be mediated by perceptual variables such as entrepreneurial self-efficacy and alert, especially in the case of female entrepreneurs. Previous studies suggest that the benefits of a same sex role model are larger for women. Using survey data from GEM Spain, our study confirms that the effect of knowing other business-owner is mediated by perception variables, although self-efficacy's mediation is only established in the case of women. Sex of the role model is not crucial in any case. (Author) 67 refs.

Negative life events and school adjustment among Chinese nursing students: The mediating role of psychological capital.

Science.gov (United States)

Liu, Chunqin; Zhao, Yuanyuan; Tian, Xiaohong; Zou, Guiyuan; Li, Ping

2015-06-01

Adjustment difficulties of college students are common and their school adjustment has gained wide concern in recent years. Negative life events and psychological capital (PsyCap) have been associated with school adjustment. However, the potential impact of negative life events on PsyCap, and whether PsyCap mediates the relationship between negative life events and school adjustment among nursing students have not been studied. To investigate the relationship among negative life events, PsyCap, and school adjustment among five-year vocational high school nursing students in China and the mediating role of PsyCap between negative life events and school adjustment. A cross-sectional survey design was conducted. 643 five-year vocational high school nursing students were recruited from three public high vocational colleges in Shandong of China. Adolescent Self-Rating Life Event Checklist (ASLEC), the Psychological Capital Questionnaire for Adolescent Students scale (PCQAS), and the Chinese College Student Adjustment Scale (CCSAS) were used in this study. Hierarchical linear regression analyses were performed to explore the mediating role of PsyCap. Negative life events were negatively associated with the dimensions of school adjustment (interpersonal relationship adaptation, learning adaptation, campus life adaptation, career adaptation, emotional adaptation, self-adaptation, and degree of satisfaction). PsyCap was positively associated with the dimensions of school adjustment and negatively associated with negative life events. PsyCap partially mediated the relationship between negative life events and school adjustment. Negative life events may increase the risk of school maladjustment in individuals with low PsyCap. Interventions designed to increase nursing students' PsyCap might buffer the stress of adverse life events, and thereby, enhance students' positive adjustment to school. Copyright © 2015 Elsevier Ltd. All rights reserved.

Authoritative Parenting and Cigarette Smoking Among Multiethnic Preadolescents: The Mediating Role of Anti-Tobacco Parenting Strategies

Science.gov (United States)

Highland, Krista B.; Tercyak, Kenneth P.; Luta, Gheorghe; Niaura, Raymond S.

2014-01-01

Introduction Parenting has been shown to affect smoking among children in U.S. majority groups, but less is known about this association among multiethnic urban populations. Our study examines the role of parenting on smoking among a highly diverse sample. Methods Health surveys were collected from eighth graders (N =459) in 2 low-income urban schools. Structural equation models examined the direct and indirect effects of authoritative parenting on lifetime smoking. A moderated mediation analysis examined whether indirect effects of authoritative parenting vary among racial/ethnic groups. Results Authoritative controlling parenting, characterized by limit setting, was positively associated with anti-tobacco parenting. Anti-tobacco parenting was inversely associated with smoking, mediating the relationship between controlling parenting and smoking. There was no evidence that mediation was moderated by race/ethnicity. Conclusions Parent training, which focuses on setting rules and expectations, can be an important and universal element of smoking prevention programs targeted to youth in diverse communities. PMID:24306966

Authoritative parenting and cigarette smoking among multiethnic preadolescents: the mediating role of anti-tobacco parenting strategies.

Science.gov (United States)

Stanton, Cassandra A; Highland, Krista B; Tercyak, Kenneth P; Luta, Gheorghe; Niaura, Raymond S

2014-01-01

Parenting has been shown to affect smoking among children in U.S. majority groups, but less is known about this association among multiethnic urban populations. Our study examines the role of parenting on smoking among a highly diverse sample. Health surveys were collected from eighth graders (N = 459) in 2 low-income urban schools. Structural equation models examined the direct and indirect effects of authoritative parenting on lifetime smoking. A moderated mediation analysis examined whether indirect effects of authoritative parenting vary among racial/ethnic groups. Authoritative controlling parenting, characterized by limit setting, was positively associated with anti-tobacco parenting. Anti-tobacco parenting was inversely associated with smoking, mediating the relationship between controlling parenting and smoking. There was no evidence that mediation was moderated by race/ethnicity. Parent training, which focuses on setting rules and expectations, can be an important and universal element of smoking prevention programs targeted to youth in diverse communities.

The Potential Role of Artificial Intelligence Technology in Education.

Science.gov (United States)

Salem, Abdel-Badeeh M.

The field of Artificial Intelligence (AI) and Education has traditionally a technology-based focus, looking at the ways in which AI can be used in building intelligent educational software. In addition AI can also provide an excellent methodology for learning and reasoning from the human experiences. This paper presents the potential role of AI in…

MEDIATOR18 and MEDIATOR20 confer susceptibility to Fusarium oxysporum in Arabidopsis thaliana

OpenAIRE

Fallath, Thorya; Kidd, Brendan N.; Stiller, Jiri; Davoine, Celine; Bj?rklund, Stefan; Manners, John M.; Kazan, Kemal; Schenk, Peer M.

2017-01-01

The conserved protein complex known as Mediator conveys transcriptional signals by acting as an intermediary between transcription factors and RNA polymerase II. As a result, Mediator subunits play multiple roles in regulating developmental as well as abiotic and biotic stress pathways. In this report we identify the head domain subunits MEDIATOR18 and MEDIATOR20 as important susceptibility factors for Fusarium oxysporum infection in Arabidopsis thaliana. Mutants of MED18 and MED20 display do...

Role of HIV-2 envelope in Lv2-mediated restriction

International Nuclear Information System (INIS)

Reuter, Sandra; Kaumanns, Patrick; Buschhorn, Sabine B.; Dittmar, Matthias T.

2005-01-01

We have characterized envelope protein pseudotyped HIV-2 particles derived from two HIV-2 isolates termed prCBL23 and CBL23 in order to define the role of the envelope protein for the Lv2-mediated restriction to infection. Previously, it has been described that the primary isolate prCBL23 is restricted to infection of several human cell types, whereas the T cell line adapted isolate CBL23 is not restricted in these cell types. Molecular cloning of the two isolates revealed that the env and the gag gene are responsible for the observed phenotype and that this restriction is mediated by Lv2, which is distinct from Ref1/Lv1 (Schmitz, C., Marchant, D., Neil, S.J., Aubin, K., Reuter, S., Dittmar, M.T., McKnight, A., Kizhatil, K., Albritton, L.M., 2004. Lv2, a novel postentry restriction, is mediated by both capsid and envelope. J. Virol. 78 (4), 2006-2016). We generated pseudotyped viruses consisting of HIV-2 (ROD-AΔenv-GFP, ROD-AΔenv-RFP, or ROD-AΔenv-REN) and the prCBL23 or CBL23 envelope proteins as well as chimeric proteins between these envelopes. We demonstrate that a single amino acid exchange at position 74 in the surface unit of CBL23-Env confers restriction to infection. This single point mutation causes tighter CD4 binding, resulting in a less efficient fusion into the cytosol of the restricted cell line. Prevention of endosome formation and prevention of endosome acidification enhance infectivity of the restricted particles for GHOST/X4 cells indicating a degradative lysosomal pathway as a cause for the reduced cytosolic entry. The described restriction to infection of the primary isolate prCBL23 is therefore largely caused by an entry defect. A remaining restriction to infection (19-fold) is preserved when endosomal acidification is prevented. This restriction to infection is also dependent on the presence of the point mutation at position 74 (G74E)

Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect.

Science.gov (United States)

Xu, Shuai; Wang, Jufang; Ding, Nan; Hu, Wentao; Zhang, Xurui; Wang, Bing; Hua, Junrui; Wei, Wenjun; Zhu, Qiyun

2015-01-01

Bystander effects can be induced through cellular communication between irradiated cells and non-irradiated cells. The signals that mediate this cellular communication, such as cytokines, reactive oxygen species, nitric oxide and even microRNAs, can be transferred between cells via gap junctions or extracellular medium. We have previously reported that miR-21, a well described DDR (DNA damage response) microRNA, is involved in radiation-induced bystander effects through a medium-mediated way. However, the mechanisms of the microRNA transfer have not been elucidated in details. In the present study, it was found that exosomes isolated from irradiated conditioned medium could induce bystander effects. Furthermore, we demonstrated plenty of evidences that miR-21, which is up-regulated as a result of mimic transfection or irradiation, can be transferred from donor or irradiated cells into extracellular medium and subsequently get access to the recipient or bystander cells through exosomes to induce bystander effects. Inhibiting the miR-21 expression in advance can offset the bystander effects to some extent. From all of these results, it can be concluded that the exosome-mediated microRNA transfer plays an important role in the radiation-induced bystander effects. These findings provide new insights into the functions of microRNAs and the cellular communication between the directly irradiated cells and the non-irradiated cells.

[Socioeconomical level and behavior in school-age children: the mediating role of parents].

Science.gov (United States)

Ulloa Vidal, Natalia; Cova Solar, Félix; Bustos N, Claudio

2017-06-01

A determinant of particular relevance in human development is the socioeconomic status (SES) and, specifically, low SES and poverty. Likewise, family environment is essential in the development of children and a potential mediator or moderator of the effect of broader social conditions. To analyze the role of parenting stress as a mediating variable of the relationship between SES and both externalized and internalized behaviors in preschool children. Descriptive secondary base study based on the Longitudinal Survey of Chilean First Infancy that selected a stratified sample, representative by clusters, of 9.996 children from 3 to 5 years old and their caregivers, that completed a battery of instruments for measuring SES variables, parenting stress and externalized and internalized behaviors. The analysis used a linear model with least square estimate. As hypothesis testing, the Dm (an adaptation of the F-test for multiple imputation method) was used. The mediation model of parenting stress in the relationship between SES and both externalized and internalized behaviors was confirmed for the latter; regarding externalized behaviors a model of moderation was observed, being the stress influence lower on the low SES. Parental stress showed a clear relationship with the presence of externalized and internalized behaviors, stronger than the SES. The relationship between SES and parenting stress is very important to understand the processes that affect children’s development.

Enhancing Role-Play Activities with Pocket Camcorder Technology: Strategies for Counselor-Educators

Science.gov (United States)

Walter, Sara Meghan; Thanasiu, Page L.

2011-01-01

Counselor-educators can benefit from specific guidelines and creative suggestions when implementing role-play and technology-related teaching strategies in counseling training programs. Therefore, the purpose of this article is to: (a) discuss the use of role-play and video recording in counselor education; (b) introduce counselor-educators to…

The mediating role of dichotomous thinking and emotional eating in the relationship between depression and BMI.

Science.gov (United States)

Antoniou, Evangelia E; Bongers, Peggy; Jansen, Anita

2017-08-01

Obesity and depression have important health implications. Although there is knowledge about the moderators of the depression-obesity association, our understanding of the potential behavioral and cognitive mediators that may explain the relationship between depression and obesity, is scarcely researched. The aim of this study is to investigate the mediating role of emotional eating and dichotomous thinking in the depression-obesity relationship. Data on 205 individuals from a community-based study conducted at Maastricht University, Netherlands were used. Self-reported data on depression, emotional eating and dichotomous thinking were collected and BMI scores were calculated in a cross-sectional research design. Correlations between variables were calculated. The primary analysis tested the hypothesis that depression has an effect on BMI through dichotomous thinking and emotional eating. A two-mediator model was used to predict the direct and indirect effects of emotional eating and dichotomous thinking on the depression-BMI relationship. Depression was positively correlated with BMI (r=0.21, p=0.005), emotional eating (r=0.38, pemotional eating were positively correlated with BMI (r=0.35, pemotional eating (Z=3.92 pemotional eating and dichotomous thinking might be useful in guiding assessment and treatment protocols for weight management. The present study adds to the existing literature on the role of dysfunctional cognitions and emotions on eating behavior, and particularly to the factors that may impede people's ability to control their eating. Copyright © 2017 Elsevier Ltd. All rights reserved.

Convergence and Spanish technological specialization: the role of multinational companies

International Nuclear Information System (INIS)

Urraca Ruiz, A.

2007-01-01

Using patent data from EPO from 1978 to 2003, this paper aims to identify the role of MNE in the determination of technological specialization trends and convergence in Spain and the extend to which the technological activity of these companies helps to define the technical distribution of competence in the country.The main findings are: (i) Spain reduces its technological distances to world along the whole period; (ii) Spanish convergence process does not seem to be accompanied by greater specialization, but greater diversification of its technological competence; (iii) Spain is specialized in a few technical fields characterized by being less dynamic and pervasive; (iv) MNE do not seem to hold strong competence in those technical fields where Spain holds technological strengths but do help to convergence process thought diversification of competence process, which is a consequence of the performance of MNE in host catching up countries, more focused on duplication of their home countries.(Author)

Expanding Technological Frames Towards Mediated Collaboration

DEFF Research Database (Denmark)

Bjørn, Pernille; Scupola, Ada; Fitzgerald, Brian

2006-01-01

This paper provides an in-depth analysis of technological and social factors leading to the successful adoption of groupware in a virtual team in educational setting. Drawing on a theoretical framework based on the concept of technological frames, we conducted an action research study to analyze...... the chronological sequence of events leading to groupware adoption. We argue that groupware adoption can be conceptualized as a three-step process of expanding and aligning individual technological frames towards groupware: The first step comprises activities facilitating participants in articulation and evaluation...... collaborative practice and use of technology, and that this activity cannot take place at the outset....

THE MEDIATING ROLE OF SOCIAL SAFENESS ON THE RELATIONSHIP BETWEEN Facebook(®) USE AND LIFE SATISFACTION.

Science.gov (United States)

Akin, Ahmet; Akin, Umran

2015-10-01

The present study examined the mediating role of social safeness on the relationship between Facebook(®) use and life satisfaction. The participants were 370 university students (M age = 20.2 yr., SD = 1.0) who completed a questionnaire package that included the Bergen Facebook(®) Addiction Scale, the Social Safeness and Pleasure Scale, and the Life Satisfaction Scale. According to the results, social safeness and life satisfaction were predicted negatively by Facebook(®) use. On the other hand, life satisfaction was predicted positively by social safeness. In addition, social safeness mediated on the relationship between Facebook(®) use and life satisfaction. The results were discussed in the light of the related literature.

Enhancing technological innovation in small firms: Role of collaboration

International Nuclear Information System (INIS)

Singh, D; Khamba, J S; Nanda, T

2014-01-01

Contribution of Micro-Small and Medium Enterprises (MSMEs) is highly remarkable in the overall industrial economy of the country. In recent years, the MSME sector has consistently registered higher growth rate compared to the overall industrial sector. With its agility and dynamism, the sector has shown admirable innovativeness and adaptability to survive the recent economic downturn and recession. However, MSMEs growth rate is still at low level. Therefore, it becomes essential for organizations to adopt new technologies or upgrade existing setup to meet continuously changing global market and fulfill customer needs. This paper explores the relationships between different collaboration networks and technological innovation of small firms through an extensive review of literature. The study finds that collaboration with larger enterprises, R and D institutions, universities and government agencies play a significant role in enhancing technological innovation in small firms

A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activation

Directory of Open Access Journals (Sweden)

Chang Chao-Chien

2011-12-01

Full Text Available Abstract Background Platelet activation is relevant to a variety of coronary heart diseases. Our previous studies revealed that sesamol possesses potent antiplatelet activity through increasing cyclic AMP formation. Although platelets are anucleated cells, they also express the transcription factor, NF-κB, that may exert non-genomic functions in platelet activation. Therefore, we further investigated the inhibitory roles of sesamol in NF-κB-mediated platelet function. Methods Platelet aggregation, Fura 2-AM fluorescence, and immunoblotting analysis were used in this study. Results NF-κB signaling events, including IKKβ phosphorylation, IκBα degradation, and p65 phosphorylation, were markedly activated by collagen (1 μg/ml in washed human platelets, and these signaling events were attenuated by sesamol (2.5~25 μM. Furthermore, SQ22536 and ODQ, inhibitors of adenylate cyclase and guanylate cyclase, respectively, strongly reversed the sesamol (25 μM-mediated inhibitory effects of IKKβ phosphorylation, IκBα degradation, and p65 phosphorylation stimulated by collagen. The protein kinase A (PKA inhibitor, H89, also reversed sesamol-mediated inhibition of IκBα degradation. Moreover, BAY11-7082, an NF-κB inhibitor, abolished IκBα degradation, phospholipase C (PLCγ2 phosphorylation, protein kinase C (PKC activation, [Ca2+]i mobilization, and platelet aggregation stimulated by collagen. Preincubation of platelets with the inhibitors, SQ22536 and H89, both strongly reversed sesamol-mediated inhibition of platelet aggregation and [Ca2+]i mobilization. Conclusions Sesamol activates cAMP-PKA signaling, followed by inhibition of the NF-κB-PLC-PKC cascade, thereby leading to inhibition of [Ca2+]i mobilization and platelet aggregation. Because platelet activation is not only linked to hemostasis, but also has a relevant role in inflammation and metastasis, our data demonstrating that inhibition of NF-κB interferes with platelet function may

Association between Work-Family Conflict and Depressive Symptoms among Chinese Female Nurses: The Mediating and Moderating Role of Psychological Capital

Directory of Open Access Journals (Sweden)

Junhui Hao

2015-06-01

Full Text Available Depressive symptoms have been in the limelight for many kinds of people, but few studies have explored positive resources for combating depressive symptoms among Chinese nurses. The purpose of this study is to explore the association between work-family conflict (WFC and depressive symptoms among Chinese female nurses, along with the mediating and moderating role of psychological capital (PsyCap in this relationship. This cross-sectional study was completed during the period of September and October 2013. A questionnaire that consisted of the Center for Epidemiologic Studies Depression Scale, the Work-Family Conflict scale and the Psychological Capital Questionnair scale was distributed to nurses in Shenyang, China. A total of 824 individuals (effective response rate: 74.9% participated. Asymptotic and resampling strategies explored the mediating role of PsyCap in the relationship between WFC and depressive symptoms. Hierarchical linear regression analyses were performed to explore the moderating role of PsyCap. Both WFC and family-work conflict (FWC were positively related with depressive symptoms. PsyCap positively moderated the relationship of WFC with depressive symptoms. Self-efficacy and hope positively moderated the relationship of WFC with depressive symptoms. PsyCap partially mediated the relationship of FWC with depressive symptoms. Hope and optimism partially mediated the relationship of FWC with depressive symptoms. Work-family conflict, as the risk factor of depressive symptoms, can increase nurses’ depressive symptoms, and PsyCap is a positive resource to combat nurses’ depressive symptoms. PsyCap can aggravate the effects of WFC on depressive symptoms and FWC can impact PsyCap to increase nurses’ depressive symptoms.

Association between Work-Family Conflict and Depressive Symptoms among Chinese Female Nurses: The Mediating and Moderating Role of Psychological Capital

Science.gov (United States)

Hao, Junhui; Wu, Di; Liu, Li; Li, Xirui; Wu, Hui

2015-01-01

Depressive symptoms have been in the limelight for many kinds of people, but few studies have explored positive resources for combating depressive symptoms among Chinese nurses. The purpose of this study is to explore the association between work-family conflict (WFC) and depressive symptoms among Chinese female nurses, along with the mediating and moderating role of psychological capital (PsyCap) in this relationship. This cross-sectional study was completed during the period of September and October 2013. A questionnaire that consisted of the Center for Epidemiologic Studies Depression Scale, the Work-Family Conflict scale and the Psychological Capital Questionnair scale was distributed to nurses in Shenyang, China. A total of 824 individuals (effective response rate: 74.9%) participated. Asymptotic and resampling strategies explored the mediating role of PsyCap in the relationship between WFC and depressive symptoms. Hierarchical linear regression analyses were performed to explore the moderating role of PsyCap. Both WFC and family-work conflict (FWC) were positively related with depressive symptoms. PsyCap positively moderated the relationship of WFC with depressive symptoms. Self-efficacy and hope positively moderated the relationship of WFC with depressive symptoms. PsyCap partially mediated the relationship of FWC with depressive symptoms. Hope and optimism partially mediated the relationship of FWC with depressive symptoms. Work-family conflict, as the risk factor of depressive symptoms, can increase nurses’ depressive symptoms, and PsyCap is a positive resource to combat nurses’ depressive symptoms. PsyCap can aggravate the effects of WFC on depressive symptoms and FWC can impact PsyCap to increase nurses’ depressive symptoms. PMID:26075725

Association between Work-Family Conflict and Depressive Symptoms among Chinese Female Nurses: The Mediating and Moderating Role of Psychological Capital.

Science.gov (United States)

Hao, Junhui; Wu, Di; Liu, Li; Li, Xirui; Wu, Hui

2015-06-12

Depressive symptoms have been in the limelight for many kinds of people, but few studies have explored positive resources for combating depressive symptoms among Chinese nurses. The purpose of this study is to explore the association between work-family conflict (WFC) and depressive symptoms among Chinese female nurses, along with the mediating and moderating role of psychological capital (PsyCap) in this relationship. This cross-sectional study was completed during the period of September and October 2013. A questionnaire that consisted of the Center for Epidemiologic Studies Depression Scale, the Work-Family Conflict scale and the Psychological Capital Questionnair scale was distributed to nurses in Shenyang, China. A total of 824 individuals (effective response rate: 74.9%) participated. Asymptotic and resampling strategies explored the mediating role of PsyCap in the relationship between WFC and depressive symptoms. Hierarchical linear regression analyses were performed to explore the moderating role of PsyCap. Both WFC and family-work conflict (FWC) were positively related with depressive symptoms. PsyCap positively moderated the relationship of WFC with depressive symptoms. Self-efficacy and hope positively moderated the relationship of WFC with depressive symptoms. PsyCap partially mediated the relationship of FWC with depressive symptoms. Hope and optimism partially mediated the relationship of FWC with depressive symptoms. Work-family conflict, as the risk factor of depressive symptoms, can increase nurses' depressive symptoms, and PsyCap is a positive resource to combat nurses' depressive symptoms. PsyCap can aggravate the effects of WFC on depressive symptoms and FWC can impact PsyCap to increase nurses' depressive symptoms.

The role of a technology demonstration program for future reactors

International Nuclear Information System (INIS)

Viktorov, A.

2011-01-01

A comprehensive technology demonstration program is seen as an important component of the overall safety case, especially for a novel technology. The objective of such a program is defined as providing objective and auditable evidence that the technology will meet or exceed the relevant requirements. Various aspects of such a program are identified and then discussed in some details in this presentation. We will show how the need for such a program is anchored in fundamental safety principles. Attributes of the program, means of achieving its objective, roles of participants, as well as key steps are all elaborated. It will be argued that to prove a novel technology, the designer will have to combine several activities such as the use of operational experience, prototyping of the technology elements, conduct of experiments and tests under representative conditions, as well as modeling and analysis. Importance of availability of experimental facilities and qualified scientific and technical staff is emphasized. A solid technology demonstration program will facilitate and speed up regulatory evaluations of licensing applications. (author)

The role of a technology demonstration program for future reactors

Energy Technology Data Exchange (ETDEWEB)

Viktorov, A. [Canadian Nuclear Safety Commission, Ottawa, Ontario (Canada)

2011-07-01

A comprehensive technology demonstration program is seen as an important component of the overall safety case, especially for a novel technology. The objective of such a program is defined as providing objective and auditable evidence that the technology will meet or exceed the relevant requirements. Various aspects of such a program are identified and then discussed in some details in this presentation. We will show how the need for such a program is anchored in fundamental safety principles. Attributes of the program, means of achieving its objective, roles of participants, as well as key steps are all elaborated. It will be argued that to prove a novel technology, the designer will have to combine several activities such as the use of operational experience, prototyping of the technology elements, conduct of experiments and tests under representative conditions, as well as modeling and analysis. Importance of availability of experimental facilities and qualified scientific and technical staff is emphasized. A solid technology demonstration program will facilitate and speed up regulatory evaluations of licensing applications. (author)

The role of action and coping planning in the relationship between intention and physical activity: a moderated mediation analysis.

Science.gov (United States)

Caudroit, Johan; Boiché, Julie; Stephan, Yannick

2014-01-01

Using a moderated mediation model, the present study investigated whether the mediation of intention into physical activity (PA) behaviour via action planning depends on the level of coping planning. A four-month prospective study was conducted among 157 French adults, who were recruited through a web-based survey. They were administrated measures of behavioural intention and sociodemographic variables at baseline and action and coping planning and PA four months later. Action planning partially mediated the contribution of intention on PA level. However, this indirect effect was conditional on the level of coping planning, insofar as action planning acted as a mediator of the intention-PA relationship only for individuals with high level of coping planning. The results highlight the complexity of the relationship between intention and behaviour and provide evidence for the distinct role of both forms of planning.

Mediating role of critical thinking disposition in the relationship between perceived barriers to research use and evidence-based practice.

Science.gov (United States)

Kim, Sun-Ae; Song, Youngshin; Sim, Hee-Sook; Ahn, Eun-Kyong; Kim, Jung-Hee

2015-01-01

Despite the importance of critical thinking in clinical and educational settings, little is known about its role in evidence-based practice (EBP). This study examined whether critical thinking disposition (CTD) mediates the relationship between perceived barriers to research use and EBP in clinical nurses (N=409). A path diagram using structural equation modeling was used to estimate the direct and indirect effects of perceived barriers to research use on EBP, controlling for CTD as a mediator. CTD partially mediated the relationship between perceived barriers to research use and EBP. Furthermore, the hypothesized mediation model demonstrated an appropriate fit to the data. Individual and organizational efforts are needed to help nurses further improve their critical thinking skills. CTD is important as research barriers to engage effectively in EBP. Without the skills to evaluate evidence carefully, research utilization may be compromised.