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Sample records for technology mast curriculum

  1. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 7: Industrial Maintenance Technology, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    Science.gov (United States)

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  2. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 11: Computer-Aided Manufacturing & Advanced CNC, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    Science.gov (United States)

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  3. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 13: Laser Machining, of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    Science.gov (United States)

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  4. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 14: Automated Equipment Technician (CIM), of a 15-Volume Set of Skill Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    Science.gov (United States)

    Texas State Technical Coll., Waco.

    This document is intended to help education and training institutions deliver the Machine Tool Advanced Skills Technology (MAST) curriculum to a variety of individuals and organizations. MAST consists of industry-specific skill standards and model curricula for 15 occupational specialty areas within the U.S. machine tool and metals-related…

  5. Engineering Technology Curriculum Guidelines

    Science.gov (United States)

    Gershon, J. J.

    1977-01-01

    Summarizes curriculum guidelines for the following engineering technologies: chemical, industrial, mining, petroleum, nuclear, civil, mechanical, electrical, automotive, and manufacturing. In a few years, these Engineering Council for Professional Development committee guidelines are intended to become the criteria by which programs will be judged…

  6. Developing human technology curriculum

    Directory of Open Access Journals (Sweden)

    Teija Vainio

    2012-10-01

    Full Text Available During the past ten years expertise in human-computer interaction has shifted from humans interacting with desktop computers to individual human beings or groups of human beings interacting with embedded or mobile technology. Thus, humans are not only interacting with computers but with technology. Obviously, this shift should be reflected in how we educate human-technology interaction (HTI experts today and in the future. We tackle this educational challenge first by analysing current Master’s-level education in collaboration with two universities and second, discussing postgraduate education in the international context. As a result, we identified core studies that should be included in the HTI curriculum. Furthermore, we discuss some practical challenges and new directions for international HTI education.

  7. Machine Tool Advanced Skills Technology (MAST). Common Ground: Toward a Standards-Based Training System for the U.S. Machine Tool and Metal Related Industries. Volume 1: Executive Summary, of a 15-Volume Set of Skills Standards and Curriculum Training Materials for the Precision Manufacturing Industry.

    Science.gov (United States)

    Texas State Technical Coll., Waco.

    The Machine Tool Advanced Skills Technology (MAST) consortium was formed to address the shortage of skilled workers for the machine tools and metals-related industries. Featuring six of the nation's leading advanced technology centers, the MAST consortium developed, tested, and disseminated industry-specific skill standards and model curricula for…

  8. Precision Machining Technology. Curriculum Guide.

    Science.gov (United States)

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This curriculum guide was developed from a Technical Committee Report prepared with the assistance of industry personnel and containing a Task List which is the basis of the guide. It presents competency-based program standards for courses in precision machining technology and is part of the Idaho Vocational Curriculum Guide Project, a cooperative…

  9. Technology, Media Monopolies and Curriculum.

    Science.gov (United States)

    Beadle, Mary E.

    Neil Postman describes the United States in the late 20th century as the only "technopoly" (a society that has totally surrendered to technology, information, and science) in the world, and he asks educators to resist technopoly by changing curriculum. In his book "Technopoly," Postman proposes that cultures may be classified…

  10. Curriculum Development and Alignment in Radiologic Technology.

    Science.gov (United States)

    Dowd, Steven B.

    Before developing a curriculum for radiologic technology, one must first attempt to define the term "curriculum." The term is not easy to define precisely, although it does imply the necessity of a master plan that outlines institutional philosophy and goals, course descriptions, description of competency-based evaluation, performance objectives,…

  11. Technology and Environmental Education: An Integrated Curriculum

    Science.gov (United States)

    Willis, Jana M.; Weiser, Brenda

    2005-01-01

    Preparing teacher candidates to integrate technology into their future classrooms effectively requires experience in instructional planning that utilizes technology to enhance student learning. Teacher candidates need to work with curriculum that supports a variety of technologies. Using Project Learning Tree and environmental education (EE),…

  12. High Gain, Very Low Areal Density, Scalable RF Apertures Enabled by Membrane Aperture Shell Technology (MAST) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose that the Membrane Aperture Shell Technology (MAST) approach be expanded with a specific focus on space exploration orbiting comm network RF aperture...

  13. Conceptualizing Student Affect for Science and Technology at the Middle School Level: Development and Implementation of a Measure of Affect in Science and Technology (MAST)

    Science.gov (United States)

    Romine, William L.; Sadler, Troy D.; Wulff, Eric P.

    2017-01-01

    We describe the development of the Measure of Affect in Science and Technology (MAST), and study its usefulness for measuring science affect in middle school students via both classical and Rasch measurement perspectives. We then proceed to utilize the measurement structure of the MAST to understand how middle school students at varying levels of…

  14. Integration of technology in the school curriculum

    Science.gov (United States)

    Treagust, David F.

    1990-01-01

    This paper describes, chronologically, the deliberations of a school staff in their decision-making to place technology education in their school. The outcome of these deliberations is a curriculum model whereby objectives of technology awareness, technological literacy, technological capability and transferable skills are integrated with all subjects in the school. The desired outcome is that students at this school will gain a technological education by, for example, attending classes in English, Home Economics, Mathematics, Social Studies, Science and Art. The implementation process is ongoing, is being evaluated and has already experienced senior staff changes and industrial disruption without loss of vigour or intent.

  15. Civil Technology. Surveying. Post Secondary Curriculum Guide.

    Science.gov (United States)

    Fitzpatrick, Beverley J.; And Others

    This curriculum guide was designed for use in postsecondary civil technology--surveying education programs in Georgia. Its purpose is to provide for development of entry level skills in surveying in the areas of knowledge, theoretical structure, tool usage, diagnostic ability, related supportive skills, and occupational survival skills. The first…

  16. Final Report: Radiation Health Technology Curriculum.

    Science.gov (United States)

    Marshall, Dwight A.; Hunt, Hiram M.

    This report describes all aspects of a radiation health technology program at a lower-division college level. Such a program must include certain basic courses, plus supplementary ones to meet the needs of local employers. To implement and sustain a curriculum, the college must (1) determine the need for it, (2) establish its objectives, (3)…

  17. Radiologic Technology Occupations. Curriculum Guide.

    Science.gov (United States)

    Reneau, Fred; And Others

    This guide delineates the tasks and performance standards for radiologic technology occupations. It includes job seeking skills, work attitudes, energy conservation practices, and safety. The guide is centered around the three domains of learning: psychomotor, cognitive, and affective. For each duty, the following are provided: task, standard of…

  18. What Is Technology Education? A Review of the "Official Curriculum"

    Science.gov (United States)

    Brown, Ryan A.; Brown, Joshua W.

    2010-01-01

    Technology education, not to be confused with educational technology, has an "official curriculum." This article explores this "official curriculum" and answers the following questions; what are the goals of technology education, what should technology education look like in classrooms, and why technology education is important. This article…

  19. On Integrating Computer Technology into Our Curriculum

    Institute of Scientific and Technical Information of China (English)

    Jianhua Bai

    2000-01-01

    @@ 1. Introduction When something new and exciting occurs in technology, some of us foreign language teachers tend to become too excited to notice the limitations of the new technology. It is no exception with the current use of multimedia and intemet technology in our curriculum. It is my belief that,without an adequate understanding of its limitations as well as its advantages, we may find ourselves disappointed as we move ahead in integrating the multimedia technology into our instruction in a meaningful way. Therefore, in this paper, I would like to start with the discussion of the limitation of multimedia technology and then discuss how we can make use of this new technology to improve our teaching and learning of Chinese as a foreign language.

  20. Conceptualizing Student Affect for Science and Technology at the Middle School Level: Development and Implementation of a Measure of Affect in Science and Technology (MAST)

    Science.gov (United States)

    Romine, William L.; Sadler, Troy D.; Wulff, Eric P.

    2017-10-01

    We describe the development of the Measure of Affect in Science and Technology (MAST), and study its usefulness for measuring science affect in middle school students via both classical and Rasch measurement perspectives. We then proceed to utilize the measurement structure of the MAST to understand how middle school students at varying levels of affect express their interest and attitudes toward science and technology and gender differences in how students express their affect. We found that affect in science and technology comprises a main dimension, science interest, and four peripheral dimensions: interest in careers in science and technology, attitudes toward science, and interest in attending science class. Of these, careers in science and technology carry the highest affective demand. While males showed higher levels of personal and situational interest in science, a greater interest in careers in science and technology was the biggest contributor to males' higher affect toward science and technology. We argue that whether the MAST is used as a measure of a single construct or multiple subconstructs depends upon specific research or evaluation goals; however, both uses of the MAST yield measures which produce valid inferences for student affect.

  1. The Technology Transfer of the ICT Curriculum in Taiwan

    Science.gov (United States)

    Huang, Teng

    2015-01-01

    Focusing on the process of "technology transfer", this paper aims to critically examine the production and usage of the information and communication technology (ICT) curriculum, and discusses its possibilities. It is found that the goals in both of the two stages of the ICT curriculum in Taiwan were rather "rhetorical". Three…

  2. Technology Education in New Zealand: The Connected Curriculum

    Science.gov (United States)

    O'Sullivan, Gary

    2010-01-01

    This paper aims to identify what actually takes place when policy directives bring together Technology Education, Enterprise Education, and the wider Community Partnerships. Since the introduction of a national technology curriculum to New Zealand schools in 1999 there has been little critique as to the intentions of the curriculum. In late 2005…

  3. Curriculum Consonance and Dissonance in Technology Education Classrooms

    Science.gov (United States)

    Brown, Ryan A.

    2009-01-01

    In a time of increased accountability, a tightened curriculum, and fewer curricular choices for students, technology education in the United States is in the position of defending itself by "carving a niche" in the school curriculum. Justifying the place of technology education is becoming increasingly difficult, as there has been little…

  4. The Technology Transfer of the ICT Curriculum in Taiwan

    Science.gov (United States)

    Huang, Teng

    2015-01-01

    Focusing on the process of "technology transfer", this paper aims to critically examine the production and usage of the information and communication technology (ICT) curriculum, and discusses its possibilities. It is found that the goals in both of the two stages of the ICT curriculum in Taiwan were rather "rhetorical". Three…

  5. Teachers enacting a technology-rich curriculum for emergent literacy

    NARCIS (Netherlands)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2011-01-01

    Cviko, A., McKenney, S., & Voogt, J. (2012). Teachers enacting a technology-rich curriculum for emergent literacy. Educational Technology Research and Development, 60(1), 31-54. doi:10.1007/s11423-011-9208-3

  6. Designing a Learning Curriculum and Technology's Role in It

    Science.gov (United States)

    Gerber, Sue; Scott, Logan

    2007-01-01

    This paper presents a case study of the design and implementation of a master's level research course. Factors that defined the curriculum design problem included the subject matter, a view of learning as a change in identity, and the role of technology in curriculum design. Both the design process and results of research on the implementation of…

  7. Aerospace Technology Curriculum Guide. Invest in Success. Vo. Ed. #260.

    Science.gov (United States)

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This document contains standards for an articulated secondary and postsecondary curriculum in aerospace technology. The curriculum standards can be used to ensure that vocational programs meet the needs of local business and industry. The first part of the document contains a task list and student performance standards for the aerospace technology…

  8. Mentoring BUGS: An Integrated Science and Technology Curriculum

    Science.gov (United States)

    Harrell, Pamela Esprivalo; Walker, Michelle; Hildreth, Bertina; Tyler-Wood, Tandra

    2004-01-01

    The current study describes an authentic learning experience designed to develop technology and science process skills through a carefully scaffolded curriculum using mealworms as a content focus. An individual mentor assigned to each 4th and 5th grade girl participating in the program delivered the curriculum. Results indicate mastery of science…

  9. Architecture for persistent surveillance using mast and UAS-based autonomous sensing with bio-inspired technologies

    Science.gov (United States)

    Burman, Jerry

    2014-06-01

    A sophisticated real time architecture for capturing relevant battlefield information of personnel and terrestrial events from a network of mast based imaging and unmanned aerial systems (UAS) with target detection, tracking, classification and visualization is presented. Persistent surveillance of personnel and vehicles is achieved using a unique spatial and temporally invariant motion detection and tracking algorithm for mast based cameras in combination with aerial remote sensing to autonomously monitor unattended ground based sensor networks. UAS autonomous routing is achieved using bio-inspired algorithms that mimic how bacteria locate nutrients in their environment. Results include field test data, performance and lessons learned. The technology also has application to detecting and tracking low observables (manned and UAS), counter MANPADS, airport bird detection and search and rescue operations.

  10. Technology Curriculum and Planning for Technology in Schools: The Flemish Case

    Science.gov (United States)

    Vanderlinde, Ruben; van Braak, Johan; De Windt, Vicky; Tondeur, Jo; Hermans, Ruben; Sinnaeve, Ilse

    2008-01-01

    As a significant step in the consolidation of the importance of technology in education, the Flemish Government recently (September 2007) introduced a formal technology curriculum for schools. This compulsory curriculum replaces already existing but non-binding technology guidelines and is an important action in the Flemish policy of educational…

  11. The Impact of Technology on High School Mathematics Curriculum

    Directory of Open Access Journals (Sweden)

    Cengiz Alacacı

    2014-02-01

    Full Text Available The infusion of technology into school mathematics has intensified in the last two decades. This article discusses the effects of this infusion on the mathematics curriculum. After a review of the different roles technology plays in mathematics and the diversity of the tools and their functions in teaching and learning mathematics, an epistemological perspective is offered to understand how technology could affect our cognition and perception while doing mathematics. With this background, specific examples are offered for the ways in which our curricular  goals are re-prioritized in algebra and geometry. The paper is concluded with a discussion of teachers' proficiency as a factor to promote effective use of technology  in the high school mathematics curriculum based on Beaudin &Bowers' (1997  PURIA model.Key Words: Technology, mathematics curriculum, algebra, geometry, high school

  12. Technology Integration in Curriculum Progress to Meet Knowledge Explosion

    Science.gov (United States)

    Joan, D. R. Robert; Denisia, S. P.; Sheeja, Y.

    2013-01-01

    The integration of technology throughout the curriculum is important to meet the needs of all learners of the 21st century. Technology can assistant teachers with the delivery of lessons and assessing students. It can also provide students with numerous ways to demonstrate their learning, increase engagement in the learning process, and help to…

  13. Nuclear Medicine Technology: A Suggested Postsecondary Curriculum.

    Science.gov (United States)

    Technical Education Research Center, Cambridge, MA.

    The purpose of this curriculum guide is to assist administrators and instructors in establishing nuclear medicine technician programs that will meet the accreditation standards of the American Medical Association (AMA) Council on Medical Education. The guide has been developed to prepare nuclear medicine technicians (NMT's) in two-year…

  14. Food Technology on the School Curriculum in England: Is It a Curriculum for the Twenty-First Century?

    Science.gov (United States)

    Rutland, Marion; Owen-Jackson, Gwyneth

    2015-01-01

    In England, food technology is part of the curriculum for design and technology but the purpose of food technology education is not clear. Over the years, food on the school curriculum has generally been seen as a practical, learning to cook, activity initially for girls to prepare them for domestic employment or housewifery. As society has…

  15. Filling the Gap with Technology Innovations: Standards, Curriculum, Collaboration, Success!

    Science.gov (United States)

    Williams, Mia Kim; Foulger, Teresa S.

    2007-01-01

    Filling the Gap with Innovations is a study of a higher education professional development model used to infuse a teacher education program with technology innovations in order to address curriculum gaps. Professional educators at the university level are not traditionally collaborative. Yet, when an assessment of program alignment to state…

  16. Central Florida Film Production Technology Training Program. Curriculum.

    Science.gov (United States)

    Valencia Community Coll., Orlando, FL.

    The Central Florida Film Production Technology Training program provided training to prepare 134 persons for employment in the motion picture industry. Students were trained in stagecraft, sound, set construction, camera/editing, and post production. The project also developed a curriculum model that could be used for establishing an Associate in…

  17. Measuring Information and Communication Technology (ICT) Curriculum Integration

    Science.gov (United States)

    Proctor, Romina M. J.; Watson, Glenice; Finger, Glenn

    2004-01-01

    There is currently a trend toward the development of methodologies to measure Information and Communication Technology (ICT) curriculum integration and its resultant impact on student learning outcomes. Simplistic, negative correlations between numbers of classroom computers and standardized literacy and numeracy test results provide headlines for…

  18. A Curriculum Framework Based on Archetypal Phenomena and Technologies.

    Science.gov (United States)

    Zubrowski, Bernie

    2002-01-01

    Presents an alternative paradigm of curriculum development based on the theory of situated cognition. This approach starts with context rather than concept, gives greater weight to students' interpretative frameworks, and provides for a more holistic development. Presents a grade 1-8 framework that uses archetypal phenomena and technologies as the…

  19. Reframing Curriculum and Pedagogical Discourse in Universities of Technology

    Science.gov (United States)

    Ntshoe, I.

    2012-01-01

    This articles aims to demystify curriculum and pedagogical discourses and related practices of sectoral occupational fields and qualifications of universities of technology (UoTs). The article takes issue with the academic tradition which emphasises distinctiveness of UoT as a sector that should focus exclusively on applied knowledge that is fixed…

  20. Teaching Science and Technology Issues: Curriculum Perspectives.

    Science.gov (United States)

    Kumar, David

    1997-01-01

    Discusses problems in teaching science and technology from a societal perspective if not handled with prudence. The misapplication of scientific and technological knowledge in Nazi Germany in World War II is explored in particular. Suggests that an issue-oriented education is needed to help students gain an overall understanding of scientific…

  1. A curriculum framework based on archetypal phenomena and technologies

    Science.gov (United States)

    Zubrowski, Bernie

    2002-07-01

    The current crop of published curriculum materials for elementary and middle school makes various claims about their relevancy to the student and their alignment with national standards. Although it may appear that they show improvement in their pedagogical practices and use of recent research, it is argued that they still are founded on questionable assumptions about student learning. The general approach of these curriculum programs is examined in relationship to issues such as the context of learning, the relationship between domain general and domain specific knowledge, and the essential role that aesthetics and personal frameworks play in conceptual change. An alternative paradigm of curriculum development is presented based on the theory of situated cognition. This approach starts with context rather than concept, gives greater weight to students' interpretative frameworks, and provides for a more holistic development. A grade 1-8 framework is presented having archetypal phenomena and technologies as the focus of investigations.

  2. Models and automation technologies for the curriculum development

    Directory of Open Access Journals (Sweden)

    V. N. Volkova

    2016-01-01

    Full Text Available The aim of the research was to determine the sequence of the curriculum development stages on the basis of the system analysis, as well as to create models and information technologies for the implementation of thesestages.The methods and the models of the systems’ theory and the system analysis, including methods and automated procedures for structuring organizational aims, models and automated procedures for organizing complex expertise.On the basis of the analysis of existing studies in the field of curriculum modeling, using formal mathematical language, including optimization models, that help to make distribution of disciplines by years and semesters in accordance with the relevant restrictions, it is shown, that the complexity and dimension of these tasks require the development of special software; the problem of defining the input data and restrictions requires a large time investment, that seems to be difficult to provide in real conditions of plans’ developing, thus it is almost impossible to verify the objectivity of the input data and the restrictions in such models. For a complete analysis of the process of curriculum development it is proposed to use the system definition, based on the system-targeted approach. On the basis of this definition the reasonable sequence of the integrated stages for the development of the curriculum was justified: 1 definition (specification of the requirements for the educational content; 2 determining the number of subjects, included in the curriculum; 3 definition of the sequence of the subjects; 4 distribution of subjects by semesters. The models and technologies for the implementation of these stages of curriculum development were given in the article: 1 models, based on the information approach of A.Denisov and the modified degree of compliance with objectives based on Denisov’s evaluation index (in the article the idea of evaluating the degree of the impact of disciplines for realization

  3. Science and Technology Teachers' Views of Primary School Science and Technology Curriculum

    Science.gov (United States)

    Yildiz-Duban, Nil

    2013-01-01

    This phenomenographic study attempts to explicit science and technology teachers' views of primary school science and technology curriculum. Participants of the study were selected through opportunistic sampling and consisted of 30 science and technology teachers teaching in primary schools in Afyonkarahisar, Turkey. Data were collected through an…

  4. How Programming Fits with Technology Education Curriculum

    Science.gov (United States)

    Wright, Geoffrey A.; Rich, Peter; Leatham, Keith R.

    2012-01-01

    Programming is a fundamental component of modern society. Programming and its applications influence much of how people work and interact. Because of people's reliance on programming in one or many of its applications, there is a need to teach students to be programming literate. Because the purpose of the International Technology and Engineering…

  5. How Programming Fits with Technology Education Curriculum

    Science.gov (United States)

    Wright, Geoffrey A.; Rich, Peter; Leatham, Keith R.

    2012-01-01

    Programming is a fundamental component of modern society. Programming and its applications influence much of how people work and interact. Because of people's reliance on programming in one or many of its applications, there is a need to teach students to be programming literate. Because the purpose of the International Technology and Engineering…

  6. Improving Information Technology Curriculum Learning Outcomes

    Directory of Open Access Journals (Sweden)

    Derrick L Anderson

    2017-06-01

    The case study research methodology has been selected to conduct the inquiry into this phenomenon. This empirical inquiry facilitates exploration of a contemporary phenomenon in depth within its real-life context using a variety of data sources. The subject of analysis will be two Information Technology classes composed of a combination of second year and third year students; both classes have six students, the same six students. Contribution It is the purpose of this research to show that the use of improved approaches to learning will produce more desirable learning outcomes. Findings The results of this inquiry clearly show that the use of the traditional behaviorist based pedagogic model to achieve college and university IT program learning outcomes is not as effective as a more constructivist based andragogic model. Recommendations Instruction based purely on either of these does a disservice to the typical college and university level learner. The correct approach lies somewhere in between them; the most successful outcome attainment would be the product of incorporating the best of both. Impact on Society Instructional strategies produce learning outcomes; learning outcomes demonstrate what knowledge has been acquired. Acquired knowledge is used by students as they pursue professional careers and other ventures in life. Future Research Learning and teaching approaches are not “one-size-fits-all” propositions; different strategies are appropriate for different circumstances and situations. Additional research should seek to introduce vehicles that will move learners away from one the traditional methodology that has been used throughout much of their educational careers to an approach that is better suited to equip them with the skills necessary to meet the challenges awaiting them in the professional world.

  7. Evolving technologies support mobile and collaborative curriculum: a case study.

    Science.gov (United States)

    Le Ber, Jeanne M; Lombardo, Nancy T

    2012-01-01

    This case study describes the efforts of librarians to integrate mobile devices, collaboration tools, and resources into a School of Medicine third-year pediatric clerkship. Additional class emphasis is on evidence-based searching and journal article evaluation and presentation. The class objectives ensure that students are comfortable with mobile devices and collaboration tools. Over the eight-year history of the course, student acceptance of the mobile devices used diminished as the devices aged, necessitating the evaluation and selection of new technologies. Collaboration tools and mobile applications employed in the course evolved to accommodate curriculum changes.

  8. A Qualitative Study on 6th Grade Science and Technology Curriculum

    Directory of Open Access Journals (Sweden)

    Yeliz Temli

    2009-12-01

    Full Text Available The rapid development in technology, the effect of globalization and economical competition between countries make educational innovations necessary. In order to harmonize new generation with scientific and technological challenges, the science and technology curriculum plays crucial role. The aim of the study is to analyze new 6th grade science and technology curriculum so as to determine its main characteristics and the main differences between formal curriculum and experienced curriculum is based on analysis of formal curriculum, interviews with science and technology teachers and one observation. In this study, the researcher addresses Posner’s (1995 curriculum analysis questions through using the documents provided, and interviews with four science and technology teachers who teach in four different cities. Additionally, one observation is conducted in a class to observe the implementation of the new curriculum in real learning environment and observe the infrastructure of school. Findings show that participant teachers are satisfied with characteristics of constructivist approach in new science and technology curriculum, whereas it is stated that they have difficulty in the implementation phase. The participants mention not only inadequate lab equipment, but also difficulty in schedule of laboratories. It is also believed that participants elicit sufficient theoretical information during their pre-service education; however, they criticize the inadequate practice sessions. It is also believed that crowded classrooms are obstacles to implement a new curriculum.

  9. Chemical Science and Technology I. A Study Guide of the Science and Engineering Technician Curriculum.

    Science.gov (United States)

    Ballinger, Jack T.; Wolf, Lawrence J.

    This study guide is part of an interdisciplinary program of studies entitled the Science and Engineering Technician (SET) Curriculum. This curriculum integrates elements from the disciplines of chemistry, physics, mathematics, mechanical technology, and electronic technology with the objective of training technicians in the use of electronic…

  10. A Curriculum Innovation Framework for Science, Technology and Mathematics Education

    Science.gov (United States)

    Tytler, Russell; Symington, David; Smith, Craig

    2011-01-01

    There is growing concern about falling levels of student engagement with school science, as evidenced by studies of student attitudes, and decreasing participation at the post compulsory level. One major response to this, the Australian School Innovation in Science, Technology and Mathematics (ASISTM) initiative, involves partnerships between schools and community and industry organisations in developing curriculum projects at the local level. This project fulfils many of the conditions advocated to engage students in learning in the sciences. ASISTM is underpinned by the notion of innovation. This paper describes the findings of case study research in which 16 ASISTM projects were selected as innovation exemplars. A definition of innovation and an innovation framework were developed, through which the case studies were analysed to make sense of the significance of the ideas and practices, participating actors, and outcomes of the projects. Through this analysis we argue that innovation is a powerful idea for framing curriculum development in the sciences at the local level that is generative for students and teachers, and that these ASISTM projects provide valuable models for engaging students, and for teacher professional learning.

  11. A Curriculum for Teaching Information Technology Investigative Techniques for Auditors

    Directory of Open Access Journals (Sweden)

    Grover S. Kearns

    2006-12-01

    Full Text Available Recent prosecutions of highly publicized white-collar crimes combined with public outrage have resulted in heightened regulation of financial reporting and greater emphasis on systems of internal control. Because both white-collar and cybercrimes are usually perpetrated through computers, internal and external auditors’ knowledge of information technology (IT is now more vital than ever. However, preserving digital evidence and investigative techniques, which can be essential to fraud examinations, are not skills frequently taught in accounting programs and instruction in the use of computer assisted auditing tools and techniques – applications that might uncover fraudulent activity – is limited. Only a few university-level accounting classes provide instruction in IT investigative techniques. This paper explains why such a course would be beneficial to the program, the college, and the student. Additionally, it presents a proposed curriculum and suggests useful resources for the instructor and student.

  12. Nuclear Medicine Technology: A Suggested Two-Year Curriculum Manual.

    Science.gov (United States)

    Hunter, David

    This curriculum guide prescribes an educational program for training nuclear medicine technologists. Following a brief section on program development, the curriculum is both outlined and presented in detail. For each of the 44 courses, the following information is given: (1) sequential placement of the course in the curriculum; (2) course…

  13. Curriculums in Industrial Technology. Plastics Technology. Industrial Maintenance. Computer Numerical Control. Teacher's Manuals and Student Learning Guides.

    Science.gov (United States)

    El Paso Community Coll., TX.

    Curriculum guides are provided for plastics technology, industrial maintenance, and computer numerical control. Each curriculum is divided into a number of courses. For each course these instructor materials are presented in the official course outline: course description, course objectives, unit titles, texts and materials, instructor resources,…

  14. The Impact of Technology-Enhanced Curriculum on Learning Advanced Algebra in US High School Classrooms

    Science.gov (United States)

    Hegedus, Stephen J.; Dalton, Sara; Tapper, John R.

    2015-01-01

    We report on two large studies conducted in advanced algebra classrooms in the US, which evaluated the effect of replacing traditional algebra 2 curriculum with an integrated suite of dynamic interactive software, wireless networks and technology-enhanced curriculum on student learning. The first study was a cluster randomized trial and the second…

  15. The Impact of Technology-Enhanced Curriculum on Learning Advanced Algebra in US High School Classrooms

    Science.gov (United States)

    Hegedus, Stephen J.; Dalton, Sara; Tapper, John R.

    2015-01-01

    We report on two large studies conducted in advanced algebra classrooms in the US, which evaluated the effect of replacing traditional algebra 2 curriculum with an integrated suite of dynamic interactive software, wireless networks and technology-enhanced curriculum on student learning. The first study was a cluster randomized trial and the second…

  16. Energy and Water Conservation Curriculum Development in Irrigation Technology for the Pacific Northwest. Final Report.

    Science.gov (United States)

    Peterson, James R.

    This project was conducted to develop curriculum materials for classes in energy and water conservation for the Irrigation Technology Program at Walla Walla Community College. To develop the curriculum, the principal investigator read and analyzed materials on the subjects of water and energy conservation, participated in a short course on drip…

  17. The Politics of Curriculum Reform in Canada: The Case of Technology Education in British Columbia.

    Science.gov (United States)

    Petrina, Stephen; Dalley, Stephen

    2003-01-01

    Demonstrates the case of technology education in British Colombia and discusses its invulnerability of teachers to curriculum reform. Draws on historical and survey data related to school practices and Ministry of Education enrollment data disaggregated by sex. Casts these data into a politics of curriculum framework informed by the work of…

  18. CERN Technical Training 2006: Software and System Technologies Curriculum - Scheduled

    CERN Multimedia

    2006-01-01

    Course Sessions (October 2006-March 2007) The Software and System Technologies Curriculum of the CERN Technical Training Programme offers comprehensive training in C++, Java, Perl, Python, XML, OO programming, JCOP/PVSS, database design and Oracle. In the PERL, C++, OO and Java course series there are some places available on the following course sessions, currently scheduled until March 2007: Object-Oriented Analysis and Design using UML: 17-19 October 2006 (3 days) JAVA 2 Enterprise Edition - Part 1: Web Applications: 19-20 October 2006 (2 days) JAVA - Level 1: 30 October -1 November 2006 (3 days) PERL 5 - Advanced Aspects: 2 November 2006 (1 day) C++ Programming Part 1 - Introduction to Object-Oriented Design and Programming: 14-16 November 2006 (3 days) JAVA - Level 2: 4-7 December 2006 (4 days) C++ Programming Part 2 - Advanced C++ and its Traps and Pitfalls: 12-15 December 2006 (4 days) JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans: 18-20 December 2006 (3 days) C++ for Particle Physicists:...

  19. Secret Codes: The Hidden Curriculum of Semantic Web Technologies

    Science.gov (United States)

    Edwards, Richard; Carmichael, Patrick

    2012-01-01

    There is a long tradition in education of examination of the hidden curriculum, those elements which are implicit or tacit to the formal goals of education. This article draws upon that tradition to open up for investigation the hidden curriculum and assumptions about students and knowledge that are embedded in the coding undertaken to facilitate…

  20. Secret Codes: The Hidden Curriculum of Semantic Web Technologies

    Science.gov (United States)

    Edwards, Richard; Carmichael, Patrick

    2012-01-01

    There is a long tradition in education of examination of the hidden curriculum, those elements which are implicit or tacit to the formal goals of education. This article draws upon that tradition to open up for investigation the hidden curriculum and assumptions about students and knowledge that are embedded in the coding undertaken to facilitate…

  1. Curriculum Management, Instructional Leadership and New Information Technology.

    Science.gov (United States)

    Carter, D. S. G.; Burger, M.

    1994-01-01

    Advocates taking advantage of pedagogically driven new-generation information management systems (IMSs) to manage curriculum, instruction, and assessment in change-oriented schools seeking to enhance effectiveness. Delineates a curriculum information management model and describes an exemplar of a new generation of IMS software. Suggests…

  2. Preservice teachers’ preparedness to integrate computer technology into the curriculum

    Directory of Open Access Journals (Sweden)

    Jelena Magliaro

    2008-05-01

    Full Text Available For Canada to compete effectively in the digital world, beginning teachers need to play an important role in integrating computer technology into the curriculum. Equipment and connectivity do not guarantee successful or productive use of computers in the classroom, but the combination of the teaching style and technology use has the potential to change education. In this research, the computer self-efficacy beliefs of 210 preservice teachers after their first practice teaching placements were examined. First, the quantitative component of the study involved the use of Computer User Self-Efficacy (CUSE scale where students’ previous undergraduate degree, licensure area, experience and familiarity with software packages were found to have statistically significant effects on computer self-efficacy. Second, the qualitative data indicated that society and school were the most positive factors that influenced preservice teachers’ attitudes towards computers, while the family had the highest percentage of negative influence. Findings reveal that although preservice teachers had completed only two months of the program, those with higher CUSE scores were more ready to integrate computers into their lessons than those with lower scores. Résumé: Pour que le Canada puisse entrer en compétition dans le monde numérique, les nouveaux enseignants devront jouer un rôle important d’intégration des technologies informatiques dans le curriculum. Les équipements et la connectivité ne garantissent pas une utilisation gagnante ou productive de l’ordinateur en salle de classe, mais la combinaison de styles d’enseignement et d’usages de la technologie a le potentiel de changer l’éducation. Dans cette étude, les croyances d’auto-efficacité à l’ordinateur de 210 futurs enseignants après leur première affectation ont été examinées. Premièrement, la partie quantitative de l’étude impliquait l’utilisation de l’échelle du Computer

  3. A Study to Compare Curriculum of Computer Information Systems and Computer Education and Instructional Technologies

    Science.gov (United States)

    Cavus, Nadire

    2008-01-01

    Today, developments of information and communication technologies have been developing very fast all over the world. These new technologies were taking an important place in education like other sciences. For this reason, education was developing parallel to new developments on the new technologies. Departments which cover curriculum of new…

  4. Mast cell proteoglycans.

    Science.gov (United States)

    Rönnberg, Elin; Melo, Fabio R; Pejler, Gunnar

    2012-12-01

    Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease. A hallmark morphological feature of mast cells is their large content of cytoplasmic secretory granules, filled with numerous secretory compounds, including highly negatively charged heparin or chondroitin sulfate proteoglycans of serglycin type. These anionic proteoglycans provide the basis for the strong metachromatic staining properties of mast cells seen when applying various cationic dyes. Functionally, the mast cell proteoglycans have been shown to have an essential role in promoting the storage of other granule-contained compounds, including bioactive monoamines and different mast cell-specific proteases. Moreover, granule proteoglycans have been shown to regulate the enzymatic activities of mast cell proteases and to promote apoptosis. Here, the current knowledge of mast cell proteoglycans is reviewed.

  5. Hydrogen Technology and Energy Curriculum (HyTEC)

    Energy Technology Data Exchange (ETDEWEB)

    Nagle, Barbara

    2013-02-28

    The Lawrence Hall of Science of the University of California, Berkeley has collaborated with scientists and engineers, a local transit agency, school districts, and a commercial curriculum publisher to develop, field-test nationally, and publish a two-week curriculum module on hydrogen and fuel cells for high school science. Key partners in this project are the Schatz Energy Research Center (SERC) of Humboldt State University, the Alameda-Contra Costa Transit District (AC Transit), FilmSight Productions, Lab-Aids, Inc., and 32 teachers and 2,370 students in field-test classrooms in California, Connecticut, Ohio, New York, South Carolina, and Washington. Field-test teachers received two to three days of professional development before teaching the curriculum and providing feedback used for revision of the curriculum. The curriculum, titled Investigating Alternative Energy: Hydrogen and Fuel Cells and published by Lab-Aids, Inc., includes a teachers guide (with lesson plans, resources, and student handout pages), two interactive computer animations, a video, a website, and a laboratory materials kit. The project has been disseminated to over 950 teachers through awareness workshops at state, regional, and national science teacher conferences.

  6. The Impact of a Geospatial Technology-Supported Energy Curriculum on Middle School Students' Science Achievement

    Science.gov (United States)

    Kulo, Violet; Bodzin, Alec

    2013-01-01

    Geospatial technologies are increasingly being integrated in science classrooms to foster learning. This study examined whether a Web-enhanced science inquiry curriculum supported by geospatial technologies promoted urban middle school students' understanding of energy concepts. The participants included one science teacher and 108 eighth-grade…

  7. Education for Sustainable Development in Technology Education in Irish Schools: A Curriculum Analysis

    Science.gov (United States)

    McGarr, Oliver

    2010-01-01

    This paper explores the integration of Education for Sustainable Development (ESD) in technology education and the extent to which it is currently addressed in curriculum documents and state examinations in technology education at post-primary level in Ireland. This analysis is conducted amidst the backdrop of considerable change in technology…

  8. A Conceptual Framework for Developing the Curriculum and Delivery of Technology Education in Early Childhood

    Science.gov (United States)

    Turja, Leena; Endepohls-Ulpe, Martina; Chatoney, Marjolaine

    2009-01-01

    The purpose of this article is to provide an overview of the analysis of the Early Childhood Education (ECE) curriculum in six countries involved in the UPDATE-project, and on that basis, propose a conceptual foundation for technology education in ECE that aims to enhance gender sensitive technology education in the continuum from early years to…

  9. Overview of MAST results

    Science.gov (United States)

    Counsell, G. F.; Akers, R. J.; Appel, L. C.; Applegate, D.; Axon, K. B.; Baranov, Y.; Brickley, C.; Bunting, C.; Buttery, R. J.; Carolan, P. G.; Challis, C.; Ciric, D.; Conway, N. J.; Cox, M.; Cunningham, G.; Darke, A.; Dnestrovskij, A.; Dowling, J.; Dudson, B.; Dunstan, M. R.; Delchambre, E.; Field, A. R.; Foster, A.; Gee, S.; Gryaznevich, M. P.; Helander, P.; Hender, T. C.; Hole, M.; Howell, D. H.; Joiner, N.; Keeling, D.; Kirk, A.; Lehane, I. P.; Lisgo, S.; Lloyd, B.; Lott, F.; Maddison, G. P.; Manhood, S. J.; Martin, R.; McArdle, G. J.; McClements, K. G.; Meyer, H.; Morris, A. W.; Nelson, M.; O'Brien, M. R.; Patel, A.; Pinfold, T.; Preinhaelter, J.; Price, M. N.; Roach, C. M.; Rozhansky, V.; Saarelma, S.; Saveliev, A.; Scannell, R.; Sharapov, S.; Shevchenko, V.; Shibaev, S.; Stammers, K.; Storrs, J.; Sykes, A.; Tabasso, A.; Tallents, S.; Taylor, D.; Tournianski, M. R.; Turner, A.; Turri, G.; Valovic, M.; Volpe, F.; Voss, G.; Walsh, M. J.; Watkins, J. R.; Wilson, H. R.; Wisse, M.; MAST, the; NBI; ECRH Teams

    2005-10-01

    Significant progress has been made on the Mega Ampere Spherical Tokamak (MAST) towards a fundamental understanding of transport, stability and edge physics and addressing technological issues for future large devices. Collaborative studies of the L-H transition with NSTX and ASDEX Upgrade confirm that operation in a connected double-null configuration significantly reduces the threshold power, Pthr. The MAST data provide support for a theory for the transition based on finite β drift wave turbulence suppression by self-generated zonal flows. Analysis of low and high field side density gradients in the H-mode pedestal provides support for an analytical model of the density pedestal width dependent on the neutral penetration depth. Adding MAST data to international confinement databases has enhanced confidence in scalings for ITER by significantly expanding the range of β and ɛ explored and indicates a slightly stronger ɛ dependence than in current scalings. Studies of core transport have been conducted for well-diagnosed L-mode, H-mode and internal transport barrier (ITB) discharges using TRANSP, and microstability and turbulence studies have been carried out using GS2. Linear micro-stability analysis indicates that ITG modes are typically unstable on all flux surfaces with growth rates that are comparable to the equilibrium E × B flow shearing rate. Mixing length estimates of transport coefficients from ITG (neglecting flow shear) give diffusion coefficients that are broadly comparable with observed thermal diffusivities. Non-linear, collisionless ETG calculations have been performed and suggest radially extended electrostatic streamers up to 100ρe across in radius. Transport from ITG could easily be suppressed in regions where the E × B shear flow rate, ωSE, exceeds the ITG growth rate, possibly contributing to ITBs. Toroidal rotation, driven by neutral beam torque, is the dominant contribution to ωSE via the vphiBθ term in the radial electric field

  10. IMMEX Problem-Solving Software: Integrating Curriculum into Technology.

    Science.gov (United States)

    Underdahl, Jennifer

    2002-01-01

    Explains the history of IMMEX (Interactive Multi-Media Exercises) and its evolution into a Web-delivered, interactive software program, which assesses student understanding of curriculum in K-16 classrooms by tracking its application in real-world, problem-solving scenarios. Discusses performance feedback for teachers and students, and offers…

  11. Printing/Graphic Arts Technology. Curriculum Guide. Invest in Success.

    Science.gov (United States)

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    Under the Idaho state system for curriculum development in vocational education, Technical Committees made up solely of industry personnel are responsible for drawing up task lists for each program. A Technical Committee Report is prepared on completion of the Committee's assignment. This report presents a task list that reflects current trends…

  12. Industrial Arts Curriculum Guide for Automated Machining in Metals Technology.

    Science.gov (United States)

    1985

    This curriculum guide is designed to be used for creating programs in automated machining education in Connecticut. The first sections of the guide are introductory, explaining the importance of computer-numerically controlled machines, describing the industrial arts scope and sequence for kindergarten through adult levels, describing the…

  13. Integrating Mobile Technologies into Very Young Second Language Learners' Curriculum

    Science.gov (United States)

    Sadykova, Gulnara; Gimaletdinova, Gulnara; Khalitova, Liliia; Kayumova, Albina

    2016-01-01

    This report is based on an exploratory case study of a private multilingual preschool language program that integrated a Mobile-Assisted Language Learning (MALL) project into the curriculum of five/six year-old children whose native language(s) is/are Russian and/or Tatar. The purpose of the study was to reveal teachers' and parents' perceptions…

  14. The Impact of a Geospatial Technology-Supported Energy Curriculum on Middle School Students' Science Achievement

    Science.gov (United States)

    Kulo, Violet; Bodzin, Alec

    2013-02-01

    Geospatial technologies are increasingly being integrated in science classrooms to foster learning. This study examined whether a Web-enhanced science inquiry curriculum supported by geospatial technologies promoted urban middle school students' understanding of energy concepts. The participants included one science teacher and 108 eighth-grade students classified in three ability level tracks. Data were gathered through pre/posttest content knowledge assessments, daily classroom observations, and daily reflective meetings with the teacher. Findings indicated a significant increase in the energy content knowledge for all the students. Effect sizes were large for all three ability level tracks, with the middle and low track classes having larger effect sizes than the upper track class. Learners in all three tracks were highly engaged with the curriculum. Curriculum effectiveness and practical issues involved with using geospatial technologies to support science learning are discussed.

  15. Essential Concepts of Engineering Design Curriculum in Secondary Technology Education

    Science.gov (United States)

    Wicklein, Robert; Smith, Phillip Cameron, Jr.; Kim, Soo Jung

    2009-01-01

    Technology education is a field of study that seeks to promote technological literacy for all students. Wright and Lauda defined technology education as a program designed to help students "develop an understanding and competence in designing, producing, and using technological products and systems, and in assessing the appropriateness of…

  16. Mississippi Curriculum Framework for Medical Radiologic Technology (Radiography) (CIP: 51.0907--Medical Radiologic Technology). Postsecondary Programs.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the radiologic technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies for the program,…

  17. First results from MAST

    DEFF Research Database (Denmark)

    Sykes, A.; Akers, R.J.; Appel, L.C.

    2001-01-01

    MAST is one of the new generation of large, purpose-built spherical tokamaks (STs) now becoming operational, designed to investigate the properties of the ST in large, collisionless plasmas. The first six months of MAST operations have been remarkably successful. Operationally, both merging-compr...

  18. Mast cells and inflammation.

    Science.gov (United States)

    Frenzel, Laurent; Hermine, Olivier

    2013-03-01

    The prominent role for mast cells in the inflammatory response has been increasingly well documented in recent years. Mast cells not only contribute to maintain homeostasis via degranulation and to generate IgE-mediated allergic reactions, but also sit at a major crossroads for both innate and adaptive immune responses. The part played by mast cells in chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis identifies mast cells as a valuable treatment target in these diseases. Tyrosine-kinase inhibitors targeting the c-Kit mast cell receptor have been found effective in treating rheumatoid arthritis, asthma, and multiple sclerosis. When used in combination with other available drugs, tyrosine-kinase inhibitors may improve the therapeutic management of these diseases.

  19. Mast cell leukemia.

    Science.gov (United States)

    Georgin-Lavialle, Sophie; Lhermitte, Ludovic; Dubreuil, Patrice; Chandesris, Marie-Olivia; Hermine, Olivier; Damaj, Gandhi

    2013-02-21

    Mast cell leukemia (MCL) is a very rare form of aggressive systemic mastocytosis accounting for mast cell activation-involvement of the liver, spleen, peritoneum, bones, and marrow-are frequent. Diagnosis is based on the presence of ≥ 20% atypical mast cells in the marrow or ≥ 10% in the blood; however, an aleukemic variant is frequently encountered in which the number of circulating mast cells is < 10%. The common phenotypic features of pathologic mast cells encountered in most forms of mastocytosis are unreliable in MCL. Unexpectedly, non-KIT D816V mutations are frequent and therefore, complete gene sequencing is necessary. Therapy usually fails and the median survival time is < 6 months. The role of combination therapies and bone marrow transplantation needs further investigation.

  20. Worlds Apart in the Curriculum: Heidegger, Technology, and the "Poietic" Attunement of Literature

    Science.gov (United States)

    Magrini, J. M.

    2012-01-01

    In this article I elucidate a conception of small worlds, or "ontological" contexts, within the curriculum that stand out and beyond the horizon of technological-scientific reality, which might be linked with forgotten, marginal ways of being and thinking. As I attempt to demonstrate, it is possible that such ontological worlds apart from…

  1. The Impact of Assistive Technology on Curriculum Accommodation for a Braille-Reading Student

    Science.gov (United States)

    Farnsworth, Charles R.; Luckner, John L.

    2008-01-01

    Over 5 months, the authors evaluated the efficacy of electronic assistive technology (the BrailleNote mPower BT-32 notetaker and Tiger Cub Jr. embosser) and associated software components in creating curriculum materials for a middle school Braille-reading student. The authors collected data at the beginning and end of the study from parents,…

  2. Predominant Teaching Strategies in Schools: Implications for Curriculum Implementation in Mathematics, Science and Technology

    Science.gov (United States)

    Achuonye, Keziah Akuoma

    2015-01-01

    This descriptive survey is hinged on predominant teaching strategies in schools, implications for curriculum implementation in Mathematics, Science and Technology. Target population consisted of teachers in primary, secondary and tertiary schools. However, purposive sample of 900 respondents was drawn from the six BRACED states namely Bayelsa,…

  3. What Classroom Technology Has Taught Me about Curriculum, Teaching, and Infinite Possibilities

    Science.gov (United States)

    Rochette, Laura Christine

    2007-01-01

    The availability of new technology and a willingness to experiment led Laura Christine Rochette to re-imagine a successful high school English curriculum. A SMART Board, individual laptop computers, and blogs became essential tools to enhance the learning of all students and to renew her excitement about teaching.

  4. Medical Radiologic Technology: A Suggested Two-Year Post High School Curriculum.

    Science.gov (United States)

    Saint Louis Community Coll. at Forest Park, MO.

    Prepared to aid in the planning and initiation of radiologic technology programs in community colleges and vocational technical schools, this curriculum guide should be useful to school administrators, advisory committees, and faculty, and may be modified to meet local, state, and regional needs. It contains full descriptions of 22 course…

  5. Effects of a Physical Education Supportive Curriculum and Technological Devices on Physical Activity

    Science.gov (United States)

    Clapham, Emily Dean; Sullivan, Eileen C.; Ciccomascolo, Lori E.

    2015-01-01

    The purpose of this study was to examine the effects of a physical education supportive curriculum and technological devices, heart rate monitor (HRM) and pedometer (PED), on physical activity. A single-subject ABAB research design was used to examine amount and level of participation in physical activity among 106 suburban fourth and fifth…

  6. Mississippi Curriculum Framework for Dental Hygiene Technology (Program CIP: 51.0602--Dental Hygienist). Postsecondary Education.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the dental hygiene technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies. Section II…

  7. Teachers conversations during design of technology rich curriculum activities for early literacy

    NARCIS (Netherlands)

    Boschman, Ferry; McKenney, Susan; Voogt, Joke

    2014-01-01

    Boschman, F., McKenney, S. & Voogt (2013). Teachers conversations during design of technology rich curriculum activities for early literacy. Paper presentation at the European Association for Practitioner Research on Improving Learning (EAPRIL) Annual Conference. November 27-29, Biel/Bienne, Switzer

  8. Predominant Teaching Strategies in Schools: Implications for Curriculum Implementation in Mathematics, Science and Technology

    Science.gov (United States)

    Achuonye, Keziah Akuoma

    2015-01-01

    This descriptive survey is hinged on predominant teaching strategies in schools, implications for curriculum implementation in Mathematics, Science and Technology. Target population consisted of teachers in primary, secondary and tertiary schools. However, purposive sample of 900 respondents was drawn from the six BRACED states namely Bayelsa,…

  9. Mission to Mars: A Collaborative Project Infusing Technology and Telecommunications into the Curriculum.

    Science.gov (United States)

    Craig, Dorothy Valcarcel; Stewart, Jaci

    1997-01-01

    Describes a collaborative project involving third and fifth graders that focused on integrating computer technology into the earth science curriculum. Electronic research, telecommunications, science software, and an interdisciplinary approach are discussed; and a list of classroom resources and three worksheets are included. (LRW)

  10. Teachers' Views about Technical Education: Implications for Reforms towards a Broad Based Technology Curriculum in Malawi

    Science.gov (United States)

    Chikasanda, Vanwyk Khobidi; Otrel-Cass, Kathrin; Jones, Alister

    2011-01-01

    Internationally there has been concern about the direction of technical education and how it is positioned in schools. This has also been the case in Malawi where the curriculum has had a strong focus on skills development. However, lately there has been a call for enhancing technological literacy of students, yet little support has been provided…

  11. Animal Science Technology. An Experimental Developmental Program. Volume II, Curriculum Course Outlines.

    Science.gov (United States)

    Brant, Herman G.

    This volume, the second of a two part evaluation report, is devoted exclusively to the presentation of detailed course outlines representing an Animal Science Technology curriculum. Arranged in 6 terms of study (2 academic years), outlines are included on such topics as: (1) Introductory Animal Science, (2) General Microbiology, (3) Zoonoses, (4)…

  12. Claiming Indigeneity through the School Curriculum, with Specific Reference to Technology Education

    Science.gov (United States)

    Gumbo, M. T.

    2012-01-01

    The development of the new curriculum post-1994 was coupled with a strong drive towards recognising and affirming the critical role of indigenous knowledge, especially with regard to science and technology (World Intellectual Property Organization, 2006). In the light of this claim, the author of this paper critically examines, from a literature…

  13. Effects of a Physical Education Supportive Curriculum and Technological Devices on Physical Activity

    Science.gov (United States)

    Clapham, Emily Dean; Sullivan, Eileen C.; Ciccomascolo, Lori E.

    2015-01-01

    The purpose of this study was to examine the effects of a physical education supportive curriculum and technological devices, heart rate monitor (HRM) and pedometer (PED), on physical activity. A single-subject ABAB research design was used to examine amount and level of participation in physical activity among 106 suburban fourth and fifth…

  14. Developing a Pre-Engineering Curriculum for 3D Printing Skills for High School Technology Education

    Science.gov (United States)

    Chien, Yu-Hung

    2017-01-01

    This study developed an integrated-STEM CO[subscript 2] dragster design course using 3D printing technology. After developing a pre-engineering curriculum, we conducted a teaching experiment to assess students' differences in creativity, race forecast accuracy, and learning performance. We compared student performance in both 3D printing and…

  15. Middle school integrated science, mathematics and technology curriculum. Final report, September 30, 1991--December 31, 1993

    Energy Technology Data Exchange (ETDEWEB)

    Brecher, K.

    1994-03-01

    The Project ``Middle School Integrated Science, Mathematics and Technology Curriculum`` had two goals: (1) to survey the literature of energy education; and (2) to develop a theme for a possible integrated middle school energy based curriculum. We aimed to respond to the challenge of developing thematic integrated curricula as advocated by the NSTA, AAAS and other organizations analyzing the future of American science and mathematics education. The survey of middle school energy curriculum materials has been completed. A list of the resources surveyed are included in this report. Though many energy based curriculum materials have been produced, none of them appears to be broadly disseminated throughout the country. Some energy based curriculum materials are far less well developed than others. We found that an integrated set of modular materials concerning the energy based theme of light and optics does not now exist. If they were developed, they could be broadly disseminated throughout middle school courses in the physical and biological sciences, as well as in new integrated science courses proposed as part of the current science education reform movement. These types of modular materials could also provide a powerful means of student exploration of new technologies such as microcomputers.

  16. Examining the Gaps between Teaching and Learning in the Technology Curriculum within Taiwan's 9-Year Articulated Curriculum Reform from the Perspective of Curriculum Implementation

    Science.gov (United States)

    Lin, Kuen-Yi; Chang, Liang-Te; Tsai, Fu-Hsing; Kao, Chia-Pin

    2015-01-01

    Curriculum reform has frequently focused on the curriculum-development stage, overlooking considerations regarding curriculum implementation, which has led to reform failure. In this study, consideration was placed primarily on the curriculum implementation stage. The gaps between teachers' and students' perceptions of content, learning…

  17. Examining the Gaps between Teaching and Learning in the Technology Curriculum within Taiwan's 9-Year Articulated Curriculum Reform from the Perspective of Curriculum Implementation

    Science.gov (United States)

    Lin, Kuen-Yi; Chang, Liang-Te; Tsai, Fu-Hsing; Kao, Chia-Pin

    2015-01-01

    Curriculum reform has frequently focused on the curriculum-development stage, overlooking considerations regarding curriculum implementation, which has led to reform failure. In this study, consideration was placed primarily on the curriculum implementation stage. The gaps between teachers' and students' perceptions of content, learning…

  18. INSTRUCTIONAL TECHNOLOGIES AND SCHOOL CURRICULUM IN NIGERIA: INNOVATIONS AND CHALLENGE

    Directory of Open Access Journals (Sweden)

    NKASIOBI S. OGUZOR

    2011-01-01

    Full Text Available The use of instructional materials in teacher training programs can provide significant input to the overall development of future teachers. Research shows that instructional materials in teacher training help student teachers to establish links between theory and practice by allowing them to make new connections between curriculum topics and the world. The new environment in which colleges develop in Nigeria has made the quality of teaching one of the main concerns and objectives. This paper discusses how to assist teachers in using instructional materials in order to help them to acquire theoretical knowledge, grounded in real practice. The paper attempts to explain the features of instructional materials and how they can assist teachers in planning quality teaching materials.

  19. Including information technology project management in the nursing informatics curriculum.

    Science.gov (United States)

    Sockolow, Paulina; Bowles, Kathryn H

    2008-01-01

    Project management is a critical skill for nurse informaticists who are in prominent roles developing and implementing clinical information systems. It should be included in the nursing informatics curriculum, as evidenced by its inclusion in informatics competencies and surveys of important skills for informaticists. The University of Pennsylvania School of Nursing includes project management in two of the four courses in the master's level informatics minor. Course content includes the phases of the project management process; the iterative unified process methodology; and related systems analysis and project management skills. During the introductory course, students learn about the project plan, requirements development, project feasibility, and executive summary documents. In the capstone course, students apply the system development life cycle and project management skills during precepted informatics projects. During this in situ experience, students learn, the preceptors benefit, and the institution better prepares its students for the real world.

  20. Influence of Science, Technology, and Engineering Curriculum on Rural Midwestern High School Student Career Decisions

    Science.gov (United States)

    Killingsworth, John

    Low degree completion in technical and engineering degrees is a growing concern for policymakers and educators in the United States. This study was an examination of the behaviors of adolescents specific to career decisions related to technology and engineering. The central research question for this study was: do rural, Midwestern high school technical and engineering curricula serve to engage students sufficiently to encourage them to persist through high school while sustaining their interests in technology and engineering careers? Engaging students in technology and engineering fields is the challenge for educators throughout the country and the Midwest. Rural schools have the additional challenge of meeting those issues because of resource limitations. Students in three Midwestern schools were surveyed to determine the level of interest in technology and engineering. The generalized likelihood ratio test was used to overcome concerns for small sample sizes. Accounting for dependent variables, multiple independent variables are examined using descriptive statistics to determine which have greater influence on career decisions, specifically those related to technology and engineering. A typical science curriculum is defined for rural Midwestern high schools. This study concludes that such curriculum achieves the goal of maintaining or increasing student interest and engagement in STEM careers. Furthermore, those schools that incorporate contextual and experiential learning activities into the curriculum demonstrate increased results in influencing student career choices toward technology and engineering careers. Implications for parents, educators, and industry professionals are discussed.

  1. Updating the biomedical engineering curriculum: Inclusion of Health Technology Assessment subjects.

    Science.gov (United States)

    Martinez Licona, Fabiola; Urbina, Edmundo Gerardo; Azpiroz-Leehan, Joaquin

    2010-01-01

    This paper describes the work being carried out at Metropolitan Autonomous University (UAM) in Mexico City with regard to the continuous evaluation and updating of the Biomedical Engineering (BME) curriculum. In particular the courses regarded as part of the BME basic branch are reduced and new sets of elective subjects are proposed in order to bring closer the research work at UAM with the subjects in the BME curriculum. Special emphasis is placed on subjects dealing with Health Technology Assessment (HTA) and Health economics, as this branch of the BME discipline is quite promising in Mexico, but there are very few professionals in the field with adequate qualifications.

  2. Bringing Business Intelligence to Health Information Technology Curriculum

    Science.gov (United States)

    Zheng, Guangzhi; Zhang, Chi; Li, Lei

    2015-01-01

    Business intelligence (BI) and healthcare analytics are the emerging technologies that provide analytical capability to help healthcare industry improve service quality, reduce cost, and manage risks. However, such component on analytical healthcare data processing is largely missed from current healthcare information technology (HIT) or health…

  3. An Integrated Business and Technology Curriculum: Oil and Water?

    Science.gov (United States)

    Hodges, Hillary Jean

    2011-01-01

    Technology in every form has become an important part of everyday life. In business, it is a necessity for success and survival. Many authors (Kotrlik & Redmann, 2009; Ma & Runyon (2004), among others) in the arena of higher education have pointed out the need for truly integrated business and technology programs at the graduate level, but…

  4. Bringing Business Intelligence to Health Information Technology Curriculum

    Science.gov (United States)

    Zheng, Guangzhi; Zhang, Chi; Li, Lei

    2015-01-01

    Business intelligence (BI) and healthcare analytics are the emerging technologies that provide analytical capability to help healthcare industry improve service quality, reduce cost, and manage risks. However, such component on analytical healthcare data processing is largely missed from current healthcare information technology (HIT) or health…

  5. Teachers' Views about Adoption and Application of Primary Science and Technology Curriculum

    Directory of Open Access Journals (Sweden)

    Ali Rıza Akdeniz

    2008-12-01

    Full Text Available The study aims to investigate teachers views about adoption and application of the Primary Science and Technology Curriculum began to be used since 2004-2005 education year. In the study, qualitative research design was used. The data were gathered through semi-structured interviews conducted with 5 classroom teachers who work at various primary schools in Çayeli/Rize. The gathered data were presented by classifying under categories. Finally, it was concluded that teachers found the new primary science curriculum as appropriate, believed it will be successful and tried to apply it effectively, but they faced some problems since they did not know it very well. The study ends with suggestions to better introduce the curriculum to the teachers and increase its effectiveness.

  6. Designing a Deeply Digital Science Curriculum: Supporting Teacher Learning and Implementation with Organizing Technologies

    Science.gov (United States)

    Leary, Heather; Severance, Samuel; Penuel, William R.; Quigley, David; Sumner, Tamara; Devaul, Holly

    2016-02-01

    This paper examines the impacts of technology (e.g., Chromebooks, Google Drive) on teacher learning and student activity in the development and implementation of a deeply digital high school biology unit. Using design-based implementation research, teachers co-designed with researchers and curriculum specialists a student-centered unit aligned to the Next Generation Science Standards (NGSS) that utilizes classroom technology. Qualitative and quantitative data were collected to understand the barriers that inhibit the implementation of a digital curriculum as well as the extent that teachers engage in the design process and begin to make shifts in their practice. We found that through the co-design process teachers began to shift their knowledge of NGSS, technology implementation, and adapted to tensions and barriers inherent in the process.

  7. Hydrogen Education Curriculum Path at Michigan Technological University

    Energy Technology Data Exchange (ETDEWEB)

    Keith, Jason; Crowl, Daniel; Caspary, David; Naber, Jeff; Allen, Jeff; Mukerjee, Abhijit; Meng, Desheng; Lukowski, John; Solomon, Barry; Meldrum, Jay

    2012-01-03

    The objective of this project was four-fold. First, we developed new courses in alternative energy and hydrogen laboratory and update existing courses in fuel cells. Secondly, we developed hydrogen technology degree programs. Thirdly, we developed hydrogen technology related course material for core courses in chemical engineering, mechanical engineering, and electrical engineering. Finally, we developed fuel cell subject material to supplement the Felder & Rousseau and the Geankoplis chemical engineering undergraduate textbooks.

  8. Mast cell activation disease

    African Journals Online (AJOL)

    EL-HAKIM

    only IgE dependent allergic diseases but also play a ... Mast cells are tissue fixed effector cells of allergic ..... alleviated high intensity symptoms of MCAD.29 ... Osteoporosis, osteolysis, bone pain: biphosphonates (vitamin D plus calcium.

  9. Tetraspanins in Mast Cells

    Directory of Open Access Journals (Sweden)

    Martin eKöberle

    2012-05-01

    Full Text Available Mast cells are key mediators of the immune system, most prominently known for their role in eliciting harmful allergic reactions. Mast cell mediator release (e. g. by degranulation is triggered by Fc{epsilon}RI recognition of antigen – IgE complexes. Until today no therapeutic targeting of this and other mast cell activation pathways is established. Among possible new candidates there are tetraspanins that have been described on mast cells already several years ago.Tetraspanins are transmembrane proteins acting as scaffolds, mediating local clustering of their interaction partners and thus amplify their activities. More recently, tetraspanins were also found to exert intrinsic receptor functions. Tetraspanins have been found to be crucial components of fundamental biological processes like cell motility and adhesion. In immune cells, they not only boost the effectiveness of antigen presentation by clustering MHC molecules, they are also key players in all kinds of degranulation events and immune receptor clustering. This review focuses on the contribution of tetraspanins clustered with Fc{epsilon}RI or residing in granule membranes to classical mast cells functions but also undertakes an outlook on the possible contribution of tetraspanins to newly described mast cell functions and discusses possible drugging strategies.

  10. An Evaluation of the "Computer Technology and Programming" Curriculum in the Vocational Higher Education System in Turkey

    Science.gov (United States)

    Adiguzel, Oktay C.; Cardak, Cigdem S.

    2009-01-01

    The purpose of this study was to evaluate the "Computer Technology and Programming" curriculum offered at vocational colleges with a focus on the goals of the curriculum and student thoughts. Document analysis and semi-structured interviews were conducted to gather the data. Results revealed that there were mainly four problematic issues…

  11. Using Task Data in Diagnostic Radiology. Research Report No. 8. Volume 2. Curriculum Objectives for Radiologic Technology.

    Science.gov (United States)

    Gilpatrick, Eleanor; Gullion, Christina

    This volume is the result of the application of the Health Services Mobility Study (HSMS) curriculum design method in radiologic technology and is presented in conjunction with volume 1, which reports the task analysis results. Volume 2 contains job-related behavioral curriculum objectives for the aide, technician, and technologist levels in…

  12. A Curriculum Innovation Framework for Science, Technology and Mathematics Education

    Science.gov (United States)

    Tytler, Russell; Symington, David; Smith, Craig

    2011-01-01

    There is growing concern about falling levels of student engagement with school science, as evidenced by studies of student attitudes, and decreasing participation at the post compulsory level. One major response to this, the Australian School Innovation in Science, Technology and Mathematics (ASISTM) initiative, involves partnerships between…

  13. Technology Needs for Teachers Web Development and Curriculum Adaptations

    Science.gov (United States)

    Carroll, Christy J.

    1999-01-01

    Computer-based mathematics and science curricula focusing on NASA inventions and technologies will enhance current teacher knowledge and skills. Materials and interactive software developed by educators will allow students to integrate their various courses, to work cooperatively, and to collaborate with both NASA scientists and students at other locations by using computer networks, email and the World Wide Web.

  14. CAE技术在井架设计中的应用%CAE Technology in the Design of the Mast

    Institute of Scientific and Technical Information of China (English)

    张明亮

    2014-01-01

    对 CAE 技术在井架设计中的应用进行深入分析,探究 ZJ30/1700CZ 钻机井架在有钩载情况、自然状态下的模态和静态,为井架的合理设计提供参考。%CAE technology in the design of the derrick-depth analysis, explore ZJ30/1700CZ rig derrick hook load in case there is, modal and static natural state, provide a reference for the rational design of the derrick.

  15. The Use of Music Technology across the Curriculum in Music Education Settings: Case Studies of Two Universities

    Science.gov (United States)

    Cremata, Radio

    2010-01-01

    This study is an investigation of the uses of music technology in music education programs in two universities. The purpose of this study was to discover the ways in which music technology was used in two schools of music across the entire music curriculum for music education students. This study detailed the ways in which music technology was…

  16. Mast cells & Company

    Directory of Open Access Journals (Sweden)

    Friederike eJönsson

    2012-02-01

    Full Text Available Classically, allergy depends on IgE antibodies and on high-affinity IgE receptors expressed by mast cells and basophils. This long accepted IgE/FcεRI/mast cell paradigm, on which the definition of immediate hypersensitivity was based in the Gell and Coomb’s classification, appears too reductionist. Recently accumulated evidence indeed requires that not only IgE but also IgG antibodies, that not only FcεRI but also FcγR of the different types, that not only mast cells and basophils but also neutrophils, monocytes, macrophages, eosinophils, and other myeloid cells by considered as important players in allergy. This view markedly changes our understanding of allergic diseases and, possibly, their treatment.

  17. The Effectiveness of a Geospatial Technologies-Integrated Curriculum to Promote Climate Literacy

    Science.gov (United States)

    Anastasio, D. J.; Bodzin, A. M.; Peffer, T.; Sahagian, D. L.; Cirucci, L.

    2011-12-01

    This study examined the effectiveness of a geospatial technologies - integrated climate change curriculum (http://www.ei.lehigh.edu/eli/cc/) to promote climate literacy in an urban school district. Five 8th grade Earth and Space Science classes in an urban middle school (Bethlehem, Pennsylvania) consisting of three different ability level tracks participated in the study. Data gathering methods included pre/posttest assessments, daily classroom observations, daily teacher meetings, and examination of student produced artifacts. Data was gathered using a climate change literacy assessment instrument designed to measure students' climate change content knowledge. The items included distractors that address misunderstandings and knowledge deficits about climate change from the existing literature. Paired-sample t-test analyses were conducted to compare the pre- and post-test assessment results. The results of these analyses were used to compare overall gains as well as ability level track groups. Overall results regarding the use of the climate change curriculum showed significant improvement in urban middle school students' understanding of climate change concepts. Effect sizes were large (ES>0.8) and significant (p<0.001) for the entire assessment and for each ability level subgroup. Findings from classroom observations, assessments embedded in the curriculum, and the examination of all student artifacts revealed that the use of geospatial technologies enable middle school students to improve their knowledge of climate change and improve their spatial thinking and reasoning skills.

  18. Technology and the delivery of the curriculum of the future: opportunities and challenges.

    Science.gov (United States)

    Sandars, John

    2012-01-01

    There is increasing availability of a wide range of technology that has the potential to support and enhance the curriculum of the future. Learners expect to use technology for their learning, but this requires the development of information and digital literacy skills to maximise the potential learning opportunities. Learning resources will be increasingly delivered by a variety of mobile devices and also through different immersive and virtual learning environments. Mobile devices and Web 2.0 technology provide opportunities for learners to create their own deep and personalised learning experiences that are relevant for future professional practice. Tutors have a crucial guidance and support role for the effective use of technology for learning. There is a little evidence base to support the impact on learning for many of the potential scenarios and further research is urgently required.

  19. Integration of computer technology into the medical curriculum: the King's experience

    Directory of Open Access Journals (Sweden)

    Vickie Aitken

    1997-12-01

    Full Text Available Recently, there have been major changes in the requirements of medical education which have set the scene for the revision of medical curricula (Towle, 1991; GMC, 1993. As part of the new curriculum at King's, the opportunity has been taken to integrate computer technology into the course through Computer-Assisted Learning (CAL, and to train graduates in core IT skills. Although the use of computers in the medical curriculum has up to now been limited, recent studies have shown encouraging steps forward (see Boelen, 1995. One area where there has been particular interest is the use of notebook computers to allow students increased access to IT facilities (Maulitz et al, 1996.

  20. Evaluation of a Cooperative Extension Service Curriculum on Empowering Older Adults with Assistive Technology to Grocery Shop, Prepare Food, and Eat

    Science.gov (United States)

    Hermann, Janice R.; Johnston, Jan H.; Brosi, Whitney A.; Jaco, Linda

    2012-01-01

    The Empowering Older Adults with Assistive Technology to Shop, Cook and Eat curriculum was designed to provide education about concepts of empowerment and assistive technology for grocery shopping, preparing food, and eating. The curriculum included examples and hands-on demonstrations of assistive technology devices for grocery shopping, food…

  1. Evaluation of a Cooperative Extension Service Curriculum on Empowering Older Adults with Assistive Technology to Grocery Shop, Prepare Food, and Eat

    Science.gov (United States)

    Hermann, Janice R.; Johnston, Jan H.; Brosi, Whitney A.; Jaco, Linda

    2012-01-01

    The Empowering Older Adults with Assistive Technology to Shop, Cook and Eat curriculum was designed to provide education about concepts of empowerment and assistive technology for grocery shopping, preparing food, and eating. The curriculum included examples and hands-on demonstrations of assistive technology devices for grocery shopping, food…

  2. CTS digital video college curriculum-sharing experiment. [Communications Technology Satellite

    Science.gov (United States)

    Lumb, D. R.; Sites, M. J.

    1974-01-01

    NASA-Ames Research Center, Stanford University, and Carleton University, Ottawa, Canada, are participating in a joint experiment to evaluate the feasibility and effectiveness of college curriculum sharing using compressed digital television and the Communications Technology Satellite (CTS). Each university will offer televised courses to the other during the 1976-1977 academic year via CTS, a joint program by NASA and the Canadian Department of Communications. The video compression techniques to be demonstrated will enable economical interconnection of educational institutions using existing and planned domestic satellites.

  3. Successful Implementation of Assistive Technology to Promote Access to Curriculum and Instruction for Students with Physical Disabilities

    Science.gov (United States)

    Coleman, Mari Beth

    2011-01-01

    Students with physical disabilities often require assistive technology to access curriculum and instruction. This paper discusses some of the issues that impede successful implementation of assistive technology for students with physical disabilities and provides a checklist that teachers and related services personnel may use when considering…

  4. Towards a gender inclusive information and communications technology curriculum: a perspective from graduates in the workforce

    Science.gov (United States)

    Koppi, Tony; Sheard, Judy; Naghdy, Fazel; Edwards, Sylvia L.; Brookes, Wayne

    2010-12-01

    An online survey was conducted of recent information and communications technology (ICT) graduates from 21 Australian universities. A range of abilities including personal/interpersonal, cognitive, business and technical were examined in relation to importance in the workplace and university preparation of those abilities. In addition, a set of six open-ended text-response questions concerned with the curriculum and other workplace preparation were asked. Quantitative and qualitative analyses revealed a range of responses that were significantly different according to gender. Amongst the significant findings are that females are more concerned than males with interpersonal communication, the development of people-skills and the people side of ICT. Implications for the ICT curriculum are that it should have more than a narrow male-centred technological focus and include the involvement of people and the effects of ICT on society in general. This broad inclusive pedagogical approach would satisfy the needs expressed by all respondents and contribute to increasing the enrolments of both female and male students in ICT.

  5. Assay of mast cell mediators

    DEFF Research Database (Denmark)

    Rådinger, Madeleine; Jensen, Bettina M; Swindle, Emily

    2015-01-01

    Mediator release from activated mast cells is a major initiator of the symptomology associated with allergic disorders such as anaphylaxis and asthma. Thus, methods to monitor the generation and release of such mediators have widespread applicability in studies designed to understand the processes...... regulating mast cell activation and for the identification of therapeutic approaches to block mast cell-driven disease. In this chapter, we discuss approaches used for the determination of mast cell degranulation, lipid-derived inflammatory mediator production, and cytokine/chemokine gene expression as well...

  6. Energy Utilization Technology Curriculum Materials FY 91. Illinois Plan for Industrial Technology Education.

    Science.gov (United States)

    Gallo, Dennis; Welty, Kenneth

    This document contains technology-based learning activities for the Illinois energy utilization technology course at the orientation level (grades 9 and 10). This packet includes a course rationale, course mission statement, course description, course outline, suggested learning objectives for each of the energy utilization areas, and suggested…

  7. Energy Utilization Technology Curriculum Materials FY 91. Illinois Plan for Industrial Technology Education.

    Science.gov (United States)

    Gallo, Dennis; Welty, Kenneth

    This document contains technology-based learning activities for the Illinois energy utilization technology course at the orientation level (grades 9 and 10). This packet includes a course rationale, course mission statement, course description, course outline, suggested learning objectives for each of the energy utilization areas, and suggested…

  8. Overview of MAST results

    Science.gov (United States)

    Chapman, I. T.; Adamek, J.; Akers, R. J.; Allan, S.; Appel, L.; Asunta, O.; Barnes, M.; Ben Ayed, N.; Bigelow, T.; Boeglin, W.; Bradley, J.; Brünner, J.; Cahyna, P.; Carr, M.; Caughman, J.; Cecconello, M.; Challis, C.; Chapman, S.; Chorley, J.; Colyer, G.; Conway, N.; Cooper, W. A.; Cox, M.; Crocker, N.; Crowley, B.; Cunningham, G.; Danilov, A.; Darrow, D.; Dendy, R.; Diallo, A.; Dickinson, D.; Diem, S.; Dorland, W.; Dudson, B.; Dunai, D.; Easy, L.; Elmore, S.; Field, A.; Fishpool, G.; Fox, M.; Fredrickson, E.; Freethy, S.; Garzotti, L.; Ghim, Y. C.; Gibson, K.; Graves, J.; Gurl, C.; Guttenfelder, W.; Ham, C.; Harrison, J.; Harting, D.; Havlickova, E.; Hawke, J.; Hawkes, N.; Hender, T.; Henderson, S.; Highcock, E.; Hillesheim, J.; Hnat, B.; Holgate, J.; Horacek, J.; Howard, J.; Huang, B.; Imada, K.; Jones, O.; Kaye, S.; Keeling, D.; Kirk, A.; Klimek, I.; Kocan, M.; Leggate, H.; Lilley, M.; Lipschultz, B.; Lisgo, S.; Liu, Y. Q.; Lloyd, B.; Lomanowski, B.; Lupelli, I.; Maddison, G.; Mailloux, J.; Martin, R.; McArdle, G.; McClements, K.; McMillan, B.; Meakins, A.; Meyer, H.; Michael, C.; Militello, F.; Milnes, J.; Morris, A. W.; Motojima, G.; Muir, D.; Nardon, E.; Naulin, V.; Naylor, G.; Nielsen, A.; O'Brien, M.; O'Gorman, T.; Ono, Y.; Oliver, H.; Pamela, S.; Pangione, L.; Parra, F.; Patel, A.; Peebles, W.; Peng, M.; Perez, R.; Pinches, S.; Piron, L.; Podesta, M.; Price, M.; Reinke, M.; Ren, Y.; Roach, C.; Robinson, J.; Romanelli, M.; Rozhansky, V.; Saarelma, S.; Sangaroon, S.; Saveliev, A.; Scannell, R.; Schekochihin, A.; Sharapov, S.; Sharples, R.; Shevchenko, V.; Silburn, S.; Simpson, J.; Storrs, J.; Takase, Y.; Tanabe, H.; Tanaka, H.; Taylor, D.; Taylor, G.; Thomas, D.; Thomas-Davies, N.; Thornton, A.; Turnyanskiy, M.; Valovic, M.; Vann, R.; Walkden, N.; Wilson, H.; van Wyk, F.; Yamada, T.; Zoletnik, S.; MAST; MAST Upgrade Teams

    2015-10-01

    The Mega Ampère Spherical Tokamak (MAST) programme is strongly focused on addressing key physics issues in preparation for operation of ITER as well as providing solutions for DEMO design choices. In this regard, MAST has provided key results in understanding and optimizing H-mode confinement, operating with smaller edge localized modes (ELMs), predicting and handling plasma exhaust and tailoring auxiliary current drive. In all cases, the high-resolution diagnostic capability on MAST is complemented by sophisticated numerical modelling to facilitate a deeper understanding. Mitigation of ELMs with resonant magnetic perturbations (RMPs) with toroidal mode number nRMP = 2, 3, 4, 6 has been demonstrated: at high and low collisionality; for the first ELM following the transition to high confinement operation; during the current ramp-up; and with rotating nRMP = 3 RMPs. nRMP = 4, 6 fields cause less rotation braking whilst the power to access H-mode is less with nRMP = 4 than nRMP = 3, 6. Refuelling with gas or pellets gives plasmas with mitigated ELMs and reduced peak heat flux at the same time as achieving good confinement. A synergy exists between pellet fuelling and RMPs, since mitigated ELMs remove fewer particles. Inter-ELM instabilities observed with Doppler backscattering are consistent with gyrokinetic simulations of micro-tearing modes in the pedestal. Meanwhile, ELM precursors have been strikingly observed with beam emission spectroscopy (BES) measurements. A scan in beta at the L-H transition shows that pedestal height scales strongly with core pressure. Gyro-Bohm normalized turbulent ion heat flux (as estimated from the BES data) is observed to decrease with increasing tilt of the turbulent eddies. Fast ion redistribution by energetic particle modes depends on density, and access to a quiescent domain with ‘classical’ fast ion transport is found above a critical density. Highly efficient electron Bernstein wave current drive (1 A W-1) has been achieved

  9. Applications in Cross-Curriculum Teaching The Synthesis of the Design Studio and Building Technology Seminar

    Directory of Open Access Journals (Sweden)

    John Enright

    2012-09-01

    Full Text Available “Change or perish. You need to prepare yourself for a profession that you are notgoing to recognize a decade from now.”Thom Mayne, Remarks on building information modeling at the 2005 AIAConvention, Las Vegas, NVToday architects are faced with new challenges involving Integrated Project Delivery and associated digital technologies that are rapidly changing the way architects work. Collaboration is the key to this newway of working as architects discover that the management of buildinginformation requires new skills and methods in design.How do educators respond to this call? How do we prepare a futuregeneration of architects to thrive within a rapidly changing profession?Given these new models for project delivery currently being utilized by theprofession, a new pair of courses was created at the Southern CaliforniaInstitute of Architecture (SCI_Arc for the integration of the designcurricula with a building technology course by emphasizing teamworkand the use of three-dimensional software. The aim was to develop newskill-sets for students while maintaining a deep understanding of designand built form. Educators have long struggled with traditional architectural curricula that inherently separate design and technology courses. This bifurcation, often times convenient and useful for the organization of aschool and curriculum, is of course at odds with the “comprehensive” nature of architectural education that is so strived for in most programs.This paper serves to show examples of an attempt to address this seriousissue within the first professional graduate school curriculum (3 1/2 yearM.ARCH by bridging both the second year design and technology classesover a two semester span. The goals of the two courses were; to bridgethe gap between design and technology pedagogy, develop collaborativetools for students, investigate a comprehensive understanding of theintegration of building systems, and to finally produce a set of documentsthat

  10. Mississippi Curriculum Framework for Marketing Management Technology (Program CIP: 52.1401--Business Mkt. & Mkt. Mgmt.). Postsecondary Programs.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the state's marketing management technology program. Presented in the introduction are a program description and suggested course sequence. Section I lists baseline competencies for the…

  11. The Making of a History Standards Wiki: "Covering", "Uncovering", and "Discovering" Curriculum Frameworks Using a Highly Interactive Technology

    Science.gov (United States)

    Maloy, Robert W.; Poirier, Michelle; Smith, Hilary K.; Edwards, Sharon A.

    2010-01-01

    This article explores using a wiki, one of the newest forms of interactive computer-based technology, as a resource for teaching the Massachusetts K-12 History and Social Science Curriculum Framework, a set of state-mandated learning standards. Wikis are web pages that can be easily edited by multiple authors. They invite active involvement by…

  12. Mississippi Curriculum Framework for Fashion Marketing Technology (Program CIP: 08.0101--Apparel and Accessories Mkt. Op., Gen.). Postsecondary Programs.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the fashion marketing technology programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies,…

  13. Investigation of Environmental Topics in the Science and Technology Curriculum and Textbooks in Terms of Environmental Ethics and Aesthetics

    Science.gov (United States)

    Lacin Simsek, Canan

    2011-01-01

    In order to solve environmental problems, it is thought that education should be connected with values. For this reason, it is emphasized that environmental issues should be integrated with ethical and aesthetic values. In this study, 6th, 7th and 8th grade science and technology curriculum and textbooks were investigated to find out how much…

  14. A Curriculum Development Route Map for a Technology Enhanced Learning Era

    Science.gov (United States)

    Castañeda, Linda; Prendes, Paz

    2013-01-01

    In this paper we are trying to present a model of analysis that includes a comprehensive perspective of the state of the art in the specialized literature about curriculum development. From this theoretical approach, we get a complete curriculum overview. Including insights into: what are the curriculum principal elements, what we already know…

  15. MAST Upgrade - Construction Status

    CERN Document Server

    Milnes, Joe; Dhalla, Fahim; Fishpool, Geoff; Hill, John; Katramados, Ioannis; Martin, Richard; Naylor, Graham; O'Gorman, Tom; Scannell, Rory

    2015-01-01

    The Mega Amp Spherical Tokamak (MAST) is the centre piece of the UK fusion research programme. In 2010, a MAST Upgrade programme was initiated with three primary objectives, to contribute to: 1) Testing reactor concepts (in particular exhaust solutions via a flexible divertor allowing Super-X and other extended leg configurations); 2) Adding to the knowledge base for ITER (by addressing important plasma physics questions and developing predictive models to help optimise ITER performance of ITER) and 3) Exploring the feasibility of using a spherical tokamak as the basis for a fusion Component Test Facility. With the project mid-way through its construction phase, progress will be reported on a number of the critical subsystems. This will include manufacture and assembly of the coils, armour and support structures that make up the new divertors, construction of the new set coils that make up the centre column, installation of the new power supplies for powering the divertor coils and enhanced TF coil set, progr...

  16. Mississippi Curriculum Framework for Emergency Medical Technology--Basic (Program CIP: 51.0904). Emergency Medical Technology--Paramedic (Program CIP: 51.0904). Postsecondary Programs.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the emergency medical technology (EMT) programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline…

  17. Histamine content and secretion in basophils and mast cells.

    Science.gov (United States)

    Dvorak, A M

    1998-01-01

    Biochemical determinations of the histamine content and secretion from basophils and mast cells have been available for some time, and much of the complex anatomy of these cellular populations and their release reactions has been documented using the electron microscope. The ultrastructural analyses led to the description of vesicular transport between secretory granules and the plasma membrane as a mechanism for secretion from basophils and mast cells--a process termed piecemeal degranulation. Proof of concepts incorporated in a general degranulation model put forth in 1975 (DVORAK, H.F. and DVORAK, A.M.) requires high magnification imaging of a granule constituent in trafficking vesicles in the process of a stimulated release reaction in which the constituent release is monitored biochemically. Development and application of a new enzyme-affinity method to detect histamine at high magnifications in well-preserved ultrastructural samples have provided the necessary means to establish proof that appropriate secretagogues can stimulate the vesicular transport of histamine in basophils and mast cells during release reactions monitored biochemically. The background information necessary to the understanding of this result is presented here, as well as the development and verification of the diamine oxidase-gold method to image histamine in human mast cell granules as the test system. Also presented are applications using this technology to examine histamine stores and secretion in vitro, in vivo, and ex vivo in human basophils and mast cells and in mouse mast cells. Specifically examined are histamine stores developing in maturing mast cells induced to develop de novo from cultured human cord blood cells, secretagogue-stimulated release and recovery of histamine stores from isolated, purified human lung mast cells ex vivo, cytokine-stimulated degranulation of human skin mast cells and their histamine stores in vivo, piecemeal degranulation of human gut mast cells and

  18. Mast cells in viral infections

    Directory of Open Access Journals (Sweden)

    Piotr Witczak

    2012-04-01

    Full Text Available  There are some premises suggesting that mast cells are involved in the mechanisms of anti-virus defense and in viral disease pathomechanisms. Mast cells are particularly numerous at the portals of infections and thus may have immediate and easy contact with the external environment and invading pathogens. These cells express receptors responsible for recognition of virus-derived PAMP molecules, mainly Toll-like receptors (TLR3, TLR7/8 and TLR9, but also RIG-I-like and NOD-like molecules. Furthermore, mast cells generate various mediators, cytokines and chemokines which modulate the intensity of inflammation and regulate the course of innate and adaptive anti-viral immunity. Indirect evidence for the role of mast cells in viral infections is also provided by clinical observations and results of animal studies. Currently, more and more data indicate that mast cells can be infected by some viruses (dengue virus, adenoviruses, hantaviruses, cytomegaloviruses, reoviruses, HIV-1 virus. It is also demonstrated that mast cells can release pre formed mediators as well as synthesize de novo eicosanoids in response to stimulation by viruses. Several data indicate that virus-stimulated mast cells secrete cytokines and chemokines, including interferons as well as chemokines with a key role in NK and Tc lymphocyte influx. Moreover, some information indicates that mast cell stimulation via TLR3, TLR7/8 and TLR9 can affect their adhesion to extracellular matrix proteins and chemotaxis, and influence expression of some membrane molecules. Critical analysis of current data leads to the conclusion that it is not yet possible to make definitive statements about the role of mast cells in innate and acquired defense mechanisms developing in the course of viral infection and/or pathomechanisms of viral diseases.

  19. KUSPACE: Embedding Science Technology and Mathematics Ambassador Activities in the Undergradiuate Engineering Curriculum

    Science.gov (United States)

    Welch, C.; Osborne, B.

    The UK national STEM Ambassadors programme provides inspiring role models for school students in science, technology, engineering, mathematics (STEM) subjects. STEMNET, the national body responsible for STEM Ambassa- dors aims to provide more than 27,000 STEM Ambassadors nationwide by the end of 2011. This paper reports on a project at Kingston University to embed STEM Ambassador training and activity in Year 2 of the undergraduate Aerospace Engineering, Astronautics and Space Technology degree. The project, known as KUSPACE (Kingston University Students Providing Amazing Classroom Experiences), was conceived to develop students' communication, planning and presentation skills and build links between different cohort years, while providing a valuable contribution to local primary schools' STEM programmes and simultaneously raising the public engagement profile of the university. This paper describes the pedagogical conception of the KUSPACE, its implementation in the curriculum, the delivery of it in the university and schools and its effect on the undergraduate students, as well as identifying good practice and drawing attention to lessons learned.STEMNET (www.stemnet.org) is the UK's Science, Technol- ogy, Engineering and Mathematics Network. Working with a broad range of UK partners and funded by the UK govern- ment's Department for Business Innovation and Skills, STEMNET plays a significant role in ensuring that five to nineteen year olds and their teachers can experience a wide range of activities and schemes which enhance and enrich the school curriculum [1]. Covering all aspects of Science, Tech- nology, Engineering and Maths (STEM), these activities and schemes are designed both to increase STEM awareness and literacy in the young people and also to encourage more of them to undertake post-16 STEM qualifications and associated careers [2]. STEMNET operates through forty-five local con- tract holders around the UK which help the network deliver its

  20. Mast cell sarcoma: clinical management.

    Science.gov (United States)

    Weiler, Catherine R; Butterfield, Joseph

    2014-05-01

    Mast cell sarcoma is a disorder that results in abnormal mast cells as identified by morphology, special stains, and in some publications, c-kit mutation analysis. It affects animal species such as canines more commonly than humans. In humans it is a very rare condition, with variable clinical presentation. There is no standard therapy for the disorder. It can affect any age group. It is occasionally associated with systemic mastocytosis and/or urticaria pigmentosa. The prognosis of mast cell sarcoma in published literature is very poor in humans.

  1. The AdditionalCurriculum of Career and Technology Learning Strand onCloth Products of Local Invention for Matthayomsueksa 2

    Directory of Open Access Journals (Sweden)

    Saifon Lasudta

    2016-09-01

    Full Text Available The purposes of this study were: 1 to develop additional curriculum in the Career and Technology Learning Strand for Mathayomsueksa 2 ; 2 to comprehend the efficiency and effectiveness of the additional curriculum developed. The samples of the study consisted of 20 parents or guardians of Mathayomsueksa 2, 5 teachers of the Career and Technology Learning Strand, and 40 Mathayomsueksa 2 of Rachaprachanukroh 16 School obtained by using the purposive sampling technique. Research instruments were as follows: 1 interview protocol consisting of 13 issues used to explore problems and needs ; 2 questionnaire with 10 items ; 3 8 lesson plans as implementing the developed additional curriculum ; 4 40-items of achievement test with discriminating power (rxy ranging from 0.49 to 0.75 and the reliability (α of 0.91. The statistics used to analyze data were percentage, mean, standard deviation and t-test (Dependent samples. Findings were as follows: 1. Fundamental data revealed that the involved persons realized that the additionalcurriculum was important and required to develop. Their opinions were at 90 percent of consensus.The components of the additional curriculum developedwere found, as evaluatedby the experts, to be appropriate and consistent with thelocal contexts. The curriculum met this criterion at 4.80 of means. The opropriateness of lesson plans was at 4.67 of means. 2. From conducting try-out activities, it revealed that: 2.1 The efficiency of the additional curriculum developed was 82.69 / 84.69.This was higher than the established criterion. 2.2 The effectiveness index of the lesson plans was 0.7100. 2.3 For learning achievement, the students’ post-test score was significantly higher than pre-test score at the .01 level of significance. 2.4 The students had process skills at the level of 4.63 Ofmeans. 2.5 The students’ satisfaction toward learning based on Thecurriculum developed was at the highest level of 4.67 of means. In summary, the

  2. The issues that class teachers encounter during application of science and technology teaching curriculum

    Directory of Open Access Journals (Sweden)

    Mustafa Ugras

    2014-08-01

    Full Text Available This study aimed at investigating the challenges class teachers face in the curriculum implementation and whether these challenges differ in relation to teachers’ gender, level of education, department they graduated from and teaching experience. For this purpose; a questionnaire was developed by the researcher. Items of the questionnaire were selected from the related literature and validated by a group of expert in the field. A pilot study was conducted to assess the clarity of the questionnaire items. The internal reliability of the final version of questionnaire was calculated by using Cronbach’s Alpha Formula and found be high (α=0.85. The participants of this research included 342 class teachers who were teaching 4th and 5th class in 57 different elementary schools in 2010-2011 academic years in Bingol and Diayrbakir cities. The results of the survey were considered by using SPSS packet program. In the analyzing of data obtained from this study, frequency, arithmetic average, t-test and variance analysis were used. From the obtained data, it was determined that the 4th and 5th class teachers encounter different problems in science and technology teaching program, especially in performance homework, sourcing and lesson time topics.

  3. Utilizing doctors' attitudes toward staff training to inform a chiropractic technology curriculum.

    Science.gov (United States)

    Eberhart, Catherine A; Martel, Stacie S

    2015-03-01

    The purpose of this study is to determine attitudes of doctors of chiropractic regarding the importance of staff training in specific skill areas to inform the curriculum management process of a chiropractic technology program. A survey was distributed to registrants of a chiropractic homecoming event. On a 5-point Likert scale, respondents were asked to rate the degree of importance that staff members be trained in specific skills. Descriptive statistics were derived, and a 1-way analysis of variance (ANOVA) was used to test differences between groups based on years in practice and level of staff training. Doctors place a high level of importance on oral communication skills and low importance on nutrition and physical examinations. Comparing groups based on years in practice revealed differences in the areas of passive physiotherapies (F = 3.61, p = .015), legal issues/regulations (F = 3.01, p = .032), occupational safety and health regulation (F = 4.27, p = .006), and marketing (F = 2.67, p = .049). Comparing groups based on level of staff training revealed differences in the areas of occupational safety and health regulations (F = 4.56, p = .005) and cardiopulmonary resuscitation (F = 4.91, p = .003). With regard to their assistants, doctors of chiropractic tend to place high importance on office skills requiring effective communication and place less importance on clinical skills such as physical examinations and physiotherapy.

  4. CERN Technical Training 2006: Software and System Technologies Curriculum - Scheduled Course Sessions (October 2006-March 2007)

    CERN Multimedia

    2006-01-01

    The Software and System Technologies Curriculum of the CERN Technical Training Programme offers comprehensive training in C++, Java, Perl, Python, XML, OO programming, JCOP/PVSS, database design and Oracle. In the Oracle, C++, OO and Java course series there are some places available on the following course sessions, currently scheduled until March 2007: Object-Oriented Analysis and Design using UML: 17-19 October 2006 (3 days) JAVA - Level 1: 30 October - 1 November 2006 (3 days) C++ Programming Part 1 - Introduction to Object-Oriented Design and Programming: 14-16 November 2006 (3 days) Oracle Database Server Administration: 23-29 November 2007 (5 days) JAVA - Level 2: 4-7 December 2006 (4 days) C++ Programming Part 2 - Advanced C++ and its Traps and Pitfalls: 12-15 December 2006 (4 days) JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans: 18-20 December 2006 (3 days) JAVA 2 Enterprise Edition - Part 1: Web Applications: 15-16 January 2007 (2 days) C++ Programming Part 3 - Templates and the STL (St...

  5. CERN Technical Training 2006: Software and System Technologies Curriculum - Scheduled Course Sessions (August-December 2006)

    CERN Multimedia

    2006-01-01

    The Software and System Technologies Curriculum of the CERN Technical Training Programme offers comprehensive training in C++, Java, Perl, Python, XML, OO programming, JCOP/PVSS, database design and Oracle. In the PERL, C++, OO and Java course series there are some places available on the following course sessions, scheduled until the end of this year: PERL 5 - Introduction: 31.8-1.9.2006 (2 days) C++ for Particle Physicists: 16-20.10.2006 (6 half days, the popular course given by Paul Kunz) Object-Oriented Analysis and Design using UML: 17-19.10.2006 (3 days) JAVA 2 Enterprise Edition - Part 1: Web Applications: 19-20.10.2006 (2 days) JAVA - Level 1: 30.10-1.11.2006 (3 days) PERL 5 - Advanced Aspects: 2.11.2006 (1 day) C++ Programming Part 1 - Introduction to Object-Oriented Design and Programming: 14-16.11.2006 (3 days) JAVA - Level 2: 4-7.12.2006 (4 days) C++ Programming Part 2 - Advanced C++ and its Traps and Pitfalls: 12-15.12.2006 (4 days) JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBea...

  6. CERN Technical Training 2006: Software and System Technologies Curriculum - Scheduled Course Sessions (October-December 2006)

    CERN Multimedia

    2006-01-01

    he Software and System Technologies Curriculum of the CERN Technical Training Programme offers comprehensive training in C++, Java, Perl, Python, XML, OO programming, JCOP/PVSS, database design and Oracle. In the PERL, C++, OO and Java course series there are some places available on the following course sessions, scheduled until the end of this year: Object-Oriented Analysis and Design using UML: 17-19 October 2006 (3 days) JAVA 2 Enterprise Edition - Part 1: Web Applications: 19-20 October 2006 (2 days) JAVA - Level 1: 30 Oct. -1 Nov. 2006 (3 days) PERL 5 - Advanced Aspects: 2 November 2006 (1 day) C++ Programming Part 1 - Introduction to Object-Oriented Design and Programming: 14-16 November 2006 (3 days) JAVA - Level 2: 4-7 December 2006 (4 days) C++ Programming Part 2 - Advanced C++ and its Traps and Pitfalls: 12-15 December 2006 (4 days) JAVA 2 Enterprise Edition - Part 2: Enterprise JavaBeans : 18.20 December 2006 (3 days) All the above sessions will be given in English, at the CERN Training Centre....

  7. Teamwork Development across the Curriculum for Information Technology Students at Liepāja University: Processes, Outcomes and Lessons Learned

    OpenAIRE

    Tomsons, Dzintars; Jansone, Anita

    2015-01-01

    Teamwork skills are key feature for Information Technology (IT) specialists. The university IT curriculum contains both IT specific courses, and comprehensive courses. Due to limited amount of the learning courses and efficient achievement of learning goals, it is necessary to look for opportunities to integrate activities developing social and communication skills courses into IT specific courses. Managing the teamwork that is close to practice, it is necessary to solve the problems of teach...

  8. Effects of the layered curriculum on student’s success, permanence and attitudes in Science and Technology Course

    OpenAIRE

    Mehmet Nuri Gömleksiz; Serav Biçer

    2012-01-01

    This study aims to determine the effects of the layered curriculum on students’ achievement, permanence and attitudes towards Science and Technology course.  The research was conducted with two classes including an experimental and a control class at 6th grade of Elazig İstiklal Primary School in 2009-2010 academic year. Mixed research model that utilize both quantitative and qualitative research methods together was preferred in this research. To that end, achievement test and attitude scale...

  9. Technologically Constructed Childhoods: Moving beyond a Reproductive to a Productive and Critical View of Curriculum Development

    Science.gov (United States)

    Fleer, Marilyn

    2011-01-01

    Many countries around the world have in place national early childhood curriculum documents for supporting educators, including Australia. It is timely for the field of early childhood education to consider the contemporary experiences of children from the twenty-first century in relation to how early childhood curriculum is framed. For instance,…

  10. Teachers Views on the Topic of Disaster Education at the Field on Elementary Science and Technology Curriculum

    Directory of Open Access Journals (Sweden)

    Esma Buluş Kırıkkaya

    2011-06-01

    Full Text Available It is reality that disasters affect all strata of society at different levels. To take an active role in reducing disaster loses of society is essential in raising awareness and the most effective way is education. In this study, first it was focused on the concept of ‘disaster’ and disaster education, then science and technology teachers’ opinions on gains, activities and the importance of explanations of disaster education in elementary school science and technology curriculum and their realization levels and the causes of difficulties that teachers faced and their ideas of how disaster education should be thought were investigated. Randomly selected from all schools in Kocaeli, 80 science and technology teachers participated the study. Likert-type scale developed by the researchers was used in the study which was followed correlative survey model. According to the results of the study, teachers found significant the disaster education curriculum, but they could not realize at the same rate, female teachers were significantly different from male teachers in terms of the given importance to the disaster curriculum and its application. At the end of the article, solutions about dissemination and continuity of the disaster education were presented in terms of the teachers’ difficulties and recommendations while they faced in disaster education.

  11. Use of multimedia technology to provide solutions to existing curriculum problems: Virtual frog dissection

    Science.gov (United States)

    Youngblut, Christine

    The objective of this research was to determine whether currently available multimedia technology can resolve existing problems in the K--12 science curriculum. There are several practical and ethical problems relating to the classroom use of animal dissection and this led to the selection of hands-on frog dissection as the curriculum activity where the use of multimedia was investigated. The major finding was that multimedia-based virtual dissection was more effective than hands-on dissection in helping students learn about frog anatomy. Moreover, this result was achieved when the time available for the virtual dissection was approximately 44% less than that available for hands-on dissection. Examination of possible relationships between student characteristics and achievement revealed that students' attitudes to educational uses of animal dissection and their computer experience were positively correlated with their achievement scores. No relationships were found between either student gender or dissection experience and achievement test outcomes. Students rated virtual dissection as the easier of the two types of dissection, though they gave equivalent ratings for their enjoyment of virtual and hands-on dissection. Despite favorable feedback on the virtual dissection, a significant majority of students stated that they felt they would be "missing-out" on a valuable experience if they were not given the opportunity to perform a hands-on frog dissection. Comparing how students spent their time during each type of dissection showed that students spent a significantly larger proportion of their time On-Task when using the multimedia-based virtual dissection. In particular, the average increase in the proportion of time spent on activities directly related to the subject matter was over 36%. Time spent On-Task had a significant positive relationship with achievement for hands-on dissection. It may play a similar role for achievement with virtual dissection, but the

  12. e Ciências Afins (MAST

    Directory of Open Access Journals (Sweden)

    Marcus Granato

    2005-01-01

    Full Text Available MAST is a science and technology museum located in the grounds and architectural complex belonging to the former Observatório Nacional in Rio de Janeiro. This complex, concluded in 1921, comprises of 16 buildings, and was listed by the Artistic and Historic National (1986 and State (1987 Heritage. This complex features three pavilions sheltering the equatorial telescopes, typical examples of Architecture and Engineering buildings for Astronomic purposes. Two of these pavilions, all of which are under the care of MAST, shelter the 21 cm and 32 cm telescopes, plus a third, part of the National Observatory, which houses the 46 cm equatorial telescope. The present study is the result of the work undertaken by MAST to preserve and restore the historical buildings under its responsibility. Thanks to a partnership set up with the Vitae Foundation, it has been possible to develop restoration work covering all aspects of the pavilions (moving metal dome, building, scientific instrument, as well as the area’s museography, with a view to informing visitors about the restoration work undertaken. The project, based on the historical research on the complex, was carried out by a multidisciplinary team over two years. Each stage of the work was comprehensively photographed, including the intervention project design, which was based on architectural surveys and the diagnosis of the complex’s state of repair, plus the restoration per se. This is a groundbreaking initiative in Latin America and will serve as an example for future actions to be taken on historical buildings, especially those built for scientific and technological purposes.

  13. Mast cells enhance T cell activation: Importance of mast cell-derived TNF

    Science.gov (United States)

    Nakae, Susumu; Suto, Hajime; Kakurai, Maki; Sedgwick, Jonathon D.; Tsai, Mindy; Galli, Stephen J.

    2005-05-01

    Mast cells are not only important effector cells in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute to T cell-mediated disorders. However, the mechanisms by which mast cells might influence T cells in such settings are not fully understood. We find that mast cells can enhance proliferation and cytokine production in multiple T cell subsets. Mast cell-dependent enhancement of T cell activation can be promoted by FcRI-dependent mast cell activation, TNF production by both mast cells and T cells, and mast cell-T cell contact. However, at high concentrations of cells, mast cells can promote T cell activation independent of IgE or TNF. Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production. allergy | asthma | autoimmunity | cytokines | immune response

  14. Technological Educational Institution of Athens, Physiotherapy Department, Papathanasiou G (Editor). Curriculum Design - Course Description

    OpenAIRE

    Papathanasiou George; Katsoulakis Kostas; Lees Philip

    2014-01-01

    The courses of the Physiotherapy Department’s curriculum cover the physiotherapeutic evaluation and rehabilitation of injuries, dysfunctions and lesions, both congenital and acquired, that cause disturbances to the skeletal, muscular, nervous, respiratory and cardiovascular systems. The basic aim and objective of the course curriculum is the development of critical thinking in the proper selection and application of the evidence based appropriate methods, techniques and means for the pr...

  15. Curriculum Evaluation and Employers Opinions: the case study of Educational Technology Program in Bachelor Degree (Continuing Program

    Directory of Open Access Journals (Sweden)

    Nakhon Lalognam

    2016-09-01

    Full Text Available The purposes of this research were: 1 to evaluate the Educational Technology Program (Continuing Program in Bachelor Degree curriculum which is revised in 2007 by applying CIPP model for evaluation. 2 to study the opinions of the employers about the ideal characteristics and actual characteristics of graduates. 3 to study the opinions for the requirements of the Educational Technology Program in Bachelor Degree (Continuing Program and knowledge implementation in work of graduates. 4 to make the suggestions and guidelines to improve the Educational Technology Program in Bachelor Degree (Continuing Program to achieve potentiality and responsive for the requirements of learners and employers. The sample of this research were 310 persons ; consisted of graduates in the Educational Technology Program in Bachelor Degree (Continuing Program in academic year 2006 - 2010, the committee of the Educational Technology Program in Bachelor Degree (Continuing Program , instructors and employers by using Multi-stage Random Sampling and Simple Random Sampling. The instruments of this research were the 5 levels rating scale questionnaire and the structured interview type. They consisted of 3 sets: 1 for graduates, 2 for the committee of the Educational Technology Program in Bachelor Degree (Continuing Program and 3 for instructors and employers. The research found that: 1. The results of evaluation on the Educational Technology Program in Bachelor Degree (Continuing Program which is revised in 2007 were: 1.1 The opinions of graduates to curriculum in all of aspects were average at the uncertain level which the context aspect was at the high level, input aspect was at the uncertain level, process aspect was at the uncertain level and product aspect was at the high level. 1.2 The opinions of the curriculum committee and instructors to curriculum in all of aspects were average at the high level which the context aspect was at the high level, input aspect was at the

  16. Mississippi Curriculum Framework for Business and Office and Related Technology Cluster. Office Systems Technology (CIP: 52.0401--Administrative Assistant/Secretarial). Accounting Technology (CIP: 52.0302). Medical Office Technology (CIP: 52.0404--Medical Admin. Asst./Secretarial). Microcomputer Technology (CIP: 52.0490). Court Reporting Technology (CIP: 52.0405). Paralegal Technology (CIP: Paralegal/Legal Assistant).

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for four programs in the postsecondary-level business and office cluster (office systems, accounting, medical office, and microcomputer technologies) and two programs in the legal cluster (court reporting and paralegal…

  17. An ability approach to within-class curriculum differentiation using student response systems and Web 2.0 technologies: Analysing teachers’ responsiveness

    Directory of Open Access Journals (Sweden)

    Matt Bower

    2012-01-01

    Full Text Available This paper examines teacher responsiveness to an ability approach of within-class curriculum differentiation using technology. Teachers were guided through a series of four workshops designed to enhance their capacity to differentiate the curriculum using Web 2.0 technologies and Student Response Systems. Anderson & Krathwohl’s (2001 Taxonomy of Learning, Teaching and Assessing was used as a framework for the within-class ability differentiation. As a result of the project there was a discernable focusing of teachers’ conceptualisations of differentiation and its value. There were also improvements in teachers’ self-reported ability to differentiate the curriculum, ability to integrate technology into the classroom, and enjoyment of using technology. Considerable variance in teachers’ capacity to differentiate according to student ability using technology was observed, indicating that a differentiated approach to supporting teachers’ development in this area may be required.

  18. Mast cells in viral infections

    OpenAIRE

    Piotr Witczak; Ewa Brzezińska-Błaszczyk

    2012-01-01

     There are some premises suggesting that mast cells are involved in the mechanisms of anti-virus defense and in viral disease pathomechanisms. Mast cells are particularly numerous at the portals of infections and thus may have immediate and easy contact with the external environment and invading pathogens. These cells express receptors responsible for recognition of virus-derived PAMP molecules, mainly Toll-like receptors (TLR3, TLR7/8 and TLR9), but also RIG-I-like and NOD-like molecules. Fu...

  19. Mast cell activation syndromes presenting as anaphylaxis.

    Science.gov (United States)

    Akin, Cem

    2015-05-01

    Anaphylaxis results from severe systemic mast cell activation. In addition to IgE-mediated and physical triggers, it may occur with a clonal mast cell disease and in an idiopathic fashion without clear provoking factors. Disorders of mast cell activation are classified into primary (clonal), secondary, and idiopathic. Mast cell activation syndrome (MCAS) is a multisystem disorder characterized by objective documentation of elevated mast cell mediators during attacks and a favorable response to antimediator therapy. It should be considered in the differential diagnosis of patients presenting with recurrent anaphylaxis without a clear cause. This article discusses the diagnosis of MCAS.

  20. MAST Upgrade – Construction Status

    Energy Technology Data Exchange (ETDEWEB)

    Milnes, Joe, E-mail: Joe.Milnes@ccfe.ac.uk; Ayed, Nizar Ben; Dhalla, Fahim; Fishpool, Geoff; Hill, John; Katramados, Ioannis; Martin, Richard; Naylor, Graham; O’Gorman, Tom; Scannell, Rory

    2015-10-15

    Highlights: • Outlines unique capability of MAST-U, including divertor and diagnostic capability. • Describes progress made in the manufacture and assembly of key MAST-U components. • Highlights the design challenges that have been overcome. • Lists the key lessons learned thus far in the project. - Abstract: The Mega Amp Spherical Tokamak (MAST) is the centre piece of the UK fusion research programme. In 2010, a MAST Upgrade programme was initiated with three primary objectives, to contribute to: (1) testing reactor concepts (in particular exhaust solutions via a flexible divertor allowing Super-X and other extended leg configurations); (2) adding to the knowledge base for ITER (by addressing important plasma physics questions and developing predictive models to help optimise ITER performance of ITER) and (3) exploring the feasibility of using a spherical tokamak as the basis for a fusion Component Test Facility. With the project mid-way through its construction phase, progress will be reported on a number of the critical subsystems. This will include manufacture and assembly of the coils, armour and support structures that make up the new divertors, construction of the new set coils that make up the centre column, installation of the new power supplies for powering the divertor coils and enhanced TF coil set, progress in delivering the upgraded diagnostic capability, the modification and upgrading of the NBI heating systems and the complete overhaul of the machine control infrastructure, including a new control room with full remote participation facilities.

  1. Mast cell Toll-like receptors (TLR

    Directory of Open Access Journals (Sweden)

    Ewa Brzezińska-Błaszczyk

    2010-02-01

    Full Text Available Taking into account the role of mast cells in different physiological and pathological processes, as well as in host defense it seems very important to recognize mast cell receptors and their role in activation of these cells. In the last few years it has been indicated that mast cells can express Toll-like receptors (TLRs, molecules that play an essential role in the activation of innate immune response to microbial pathogens and take part in the development of adaptive immunity, as well. It has been defined that mast cells express TLR2, TLR4, TLR1 and TLR6. There is also some data proving that mast cells possess TLR5, TLR3 and TLR9 molecules. The presence of TLR7, TLR9, and TLR10 on mast cells is still unclear. Some data indicate that TLR expression by mast cells can be modulated by various cytokines, such as granulocyte-macrophage colony stimulating factor (GM-CSF and interferon (IFN-γ, cathelicidin LL-37 as well as by some bacterial components. It is now established that TLRs are involved in mast cell response to bacterial stimulation; some data also indicate that TLRs take part in virus-induced mast cell activation. What is more, it is now suggested that TLRs might regulate IgE-FcεRI-dependent mast cell stimulation. Further research is needed to fully understand and describe the role of TLRs in mast cell biology.

  2. Lipid Rafts in Mast Cell Biology

    Directory of Open Access Journals (Sweden)

    Adriana Maria Mariano Silveira e Souza

    2011-01-01

    Full Text Available Mast cells have long been recognized to have a direct and critical role in allergic and inflammatory reactions. In allergic diseases, these cells exert both local and systemic responses, including allergic rhinitis and anaphylaxis. Mast cell mediators are also related to many chronic inflammatory conditions. Besides the roles in pathological conditions, the biological functions of mast cells include roles in innate immunity, involvement in host defense mechanisms against parasites, immunomodulation of the immune system, tissue repair, and angiogenesis. Despite their growing significance in physiological and pathological conditions, much still remains to be learned about mast cell biology. This paper presents evidence that lipid rafts or raft components modulate many of the biological processes in mast cells, such as degranulation and endocytosis, play a role in mast cell development and recruitment, and contribute to the overall preservation of mast cell structure and organization.

  3. REFLECTIONS ON SCIENCE AND TECHNOLOGY CURRICULUM IN THE FOURTH GRADE ‘THE EXAMPLE OF ADANA CITY’

    Directory of Open Access Journals (Sweden)

    Mehmet KARAKUŞ

    2013-06-01

    Full Text Available The national policy in 2004 aimed to develop the curriculum in Science andTechnology classes and to keep up with the change sand progress happening. Given the developed curriculum of Science andTechnology, it can be seen that the constructivist learning theory was adopted (Gömleksiz & Bulut, 2005. Students in the fourth grade the first encounter with the curriculum of Science and Technology. In this regard, students learn the concepts of the fourth grade program correct and complete construction is extremely important the correct the construction of science concepts in their minds. In this context, the new curriculum is based on science and technology skills and knowledge required by the constructivist approach is of great importance for fourth grade teachers. Therefore, based on the constructivist approach teachers teaching methods and techniques are required to have sufficient knowledge and skills to practice (Gömleksiz & Bulut, 2005. The constructivist philosophy recommends the radical changes related to the arrangement of the class and realization of the education. However, the studies showed that the constructivist approach present in the curriculum was not administered in the clasroom environment, and that the teaching was maintained through teacher-centric applications. (Bozyılmaz& Bağcı-Kılıç, 2005; Saylan & Yurdakul, 2005; Yaşar, Gültekin, Türkkan, Yıldız, & Girmen, 2005. Correspondingly, Anagün, Yalçınoğluand Ersoy (2012 found that only one-third of the fiften ones adopted the constructivist approach but only two of them put the approach in to practice. This study aimed to describe the present situation and the problems encountered in terms of the objectives, activities and assessment based on the constructivist approach in science and technology classes in the fourth grades. The findings obtained are thought to shedlight on curriculum development. The methodology of this study is descriptive. The classes related were

  4. Developing a Consensus-Driven, Core Competency Model to Shape Future Audio Engineering Technology Curriculum: A Web-Based Modified Delphi Study

    Science.gov (United States)

    Tough, David T.

    2009-01-01

    The purpose of this online study was to create a ranking of essential core competencies and technologies required by AET (audio engineering technology) programs 10 years in the future. The study was designed to facilitate curriculum development and improvement in the rapidly expanding number of small to medium sized audio engineering technology…

  5. Science and Technology Education for the Middle Years: Frameworks for Curriculum and Instruction.

    Science.gov (United States)

    Bybee, Rodger W.; And Others

    In the rising tide of reports proclaiming the need to reform various aspects of education, middle level education has been frequently overlooked. The Study Panel on Curriculum and Instruction of the National Center for Improving Science Education recognizes the critical development that occurs during early adolescence and the current reform toward…

  6. Science and Technology Education for the Elementary Years: Frameworks for Curriculum and Instruction.

    Science.gov (United States)

    Bybee, Rodger W.; And Others

    This report is a policy statement for science curriculum and instruction in elementary schools. It describes a set of organizing principles that incorporate what science ought to be taught, and a learning sequence that illustrates how more "hand-on, minds-on" science can become more prevalent in our schools. Chapters included are: (1)…

  7. Chemical Science and Technology II. A Study Guide of the Science and Engineering Technician Curriculum.

    Science.gov (United States)

    Ballinger, Jack T.; Wolf, Lawrence J.

    This study guide is part of a program of studies entitled the Science and Engineering Technician (SET) Curriculum developed to provide a framework for training technicians in the use of electronic instruments and their applications. This interdisciplinary course of study integrates elements from the disciplines of chemistry, physics, mathematics,…

  8. The Doubles: A Case Study on Developing a Technology-Based Substance Abuse Education Curriculum

    Science.gov (United States)

    Epstein, Joel; Collins, Karen Kadela; Pancella, Thom

    2004-01-01

    The Doubles, funded by the National Institute on Drug Abuse, is a seven-episode series of media tools designed to teach third and fourth grade students about the science of drug addiction. The program's curriculum is delivered via a set of videos, interactive CD-ROMs, workbooks, or an Internet site. This article examines the process used to…

  9. THE COHERENCE BETWEEN CLASSROOM TEACHERS’ IMPLEMENTATION OF SCIENCE AND TECHNOLOGY CURRICULUM AND THEIR BELIEFS ABOUT SCIENCE EDUCATION

    Directory of Open Access Journals (Sweden)

    Gökhan SERİN

    2014-06-01

    Full Text Available The purpose of this study was to investigate coherence between classroom teachers’ practices of elementary science and technology curriculum and their beliefs about science education. The study was designed as a qualitative study in which case study method was used. The participants of the study were five classroom teachers whose professional experience was over 15 years. The classes of these teachers were observed throughout one academic year such that three class hours per month. Moreover, the teachers were interviewed and voice-recorder was used. In order to support qualitative data related with beliefs about science education, a science education belief scale was also administered. Therefore, the data was collected through classroom observations, teacher interviews, and the science education belief scale. Descriptive analysis method was used in data analysis. The findings revealed that there was no exact coherence between teachers’ classroom practices of science and technology curriculum and their beliefs about science education. The reasons of inconsistency between teaching practices and beliefs were discussed in light of the findings.

  10. Family and Consumer Sciences Technology-Life-Careers Core Curriculum. A Curriculum Guide. A Family and Consumer Sciences Education Course of Study for Grades 6-7.

    Science.gov (United States)

    Utah State Office of Education, Salt Lake City.

    This curriculum, part of a coordinated exploratory vocational core program, is an activity-oriented instructional course that enables students in grades 6-7 to explore careers and skills related to consumer and occupational roles. The curriculum consists of five units: (1) independent living skills; (2) families; (3) child care; (4) textiles…

  11. How Will Access and Reliability of Information Communications Technology Resources Affect the Potential Implementation of the Australian Curriculum?

    Science.gov (United States)

    Murray, Gemma

    2014-01-01

    The Australian Government has recently introduced a national based curriculum, known as The Australian Curriculum. This new curriculum is intended to provide quality education for all students (Australian Curriculum, Reporting and Assessment Authority, [ACARA], 2013). This article considers some of the possible implications of the Australian…

  12. Paths through interpretive territory: Two teachers' enactment of a technology-rich, inquiry-fostering science curriculum

    Science.gov (United States)

    McDonald, Scott Powell

    New understandings about how people learn and constructivist pedagogy pose challenges for teachers. Science teachers face an additional challenge of developing inquiry-based pedagogy to foster complex reasoning skills. Theory provides only fuzzy guidance as to how constructivist or inquiry pedagogy can be accomplished in a wide variety of contexts and local constraints. This study contributes to the understanding of the development of constructivist, inquiry-based pedagogy by addressing the question: How do teachers interpret and enact a technology-rich, inquiry fostering science curricula for fifth grade students' biodiversity learning? This research is a case study of two teachers chosen as critical contrasting cases and represent differences across multiple criteria including: urban I suburban, teaching philosophy, and content preparation. The two fifth grade teachers each enacted BioKIDS: Kids' Inquiry in Diverse Species, an eight week curriculum focused on biodiversity. BioKIDS incorporates multiple learning technologies to support student learning including handheld computer software designed to help students collect field data, and a web-based resource for data on local animal species. The results of this study indicate there are tensions teachers must struggle with when setting goals during enactment of inquiry science curricula. They must find a balance between an emphasis on authentic learning and authentic science, and between natural history and natural science. Authentic learning focuses on students' interests and lives; Authentic science focuses on students working with the tools and processes of science. Natural history focuses on the foundational skills in science of observation and classification. Natural science focuses on analytical science drawing on data to develop claims about the world. These two key tensions in teachers' goal setting were critical in defining and understanding differences in how teachers interpreted a curriculum to meet

  13. Generation, isolation, and maintenance of rodent mast cells and mast cell lines

    DEFF Research Database (Denmark)

    Jensen, Bettina M; Swindle, Emily J; Iwaki, Shoko;

    2006-01-01

    Antigen-mediated mast cell activation, with subsequent mediator release, is a major initiator of the inflammatory allergic response associated with such conditions as asthma. A comprehensive understanding of the principles involved in this process therefore is key to the development of novel...... therapies for the treatment of these disease states. In vitro models of mast cell function have allowed significant progress to be made in the recognition of the fundamental principles of mast cell activation via the high-affinity IgE receptor (FcvarepsilonRI) and, more recently, other receptors expressed...... on mast cells. In addition to human mast cells, the major cell culture systems employed to investigate these responses are rat and mouse peritoneal mast cells, mouse bone-marrow-derived mast cells, the rat basophilic leukemia cell line RBL-2H3, and the mouse MC/9 mast cell line. In this unit, we describe...

  14. The mast on the house

    DEFF Research Database (Denmark)

    Landberg, L.

    1997-01-01

    An often encountered problem when preparing the basic input data for a wind atlas is the correction for the influence of the house or hut on which the mast - whose data forms the basis of this wind atlas - is placed. The paper will describe an experiment, where this problem has been addressed....... The knowledge gained will be used to give guide-lines as to the use of the WASP program to correct the observations. Should the house/hut simply be treated as an extension of the mast, should the house/hut be treated as a hill with speed-up effects, or should the house/hill be ignored completely? The paper...... will show that the house/hut should indeed be treated as a hill with speed-up effects. Placing meteorological masts on houses or huts is common practice in quite a few countries in the world. The problem is therefore one which most people involved in detailed wind resource assessment will face sooner...

  15. Correlation of mast cells in periodontal diseases

    OpenAIRE

    Sushma S Lagdive; Lagdive, Sanjay B; Mani, Ameet; Anarthe, Raju; Pendyala, Gowri; Pawar, Babita; Marawar, Pramod P.

    2013-01-01

    Background: Among the cells involved in immune and inflammatory responses in periodontal disease, mast cells have been shown to be capable of generating a large number of biologically active substances. Mast cells are mobile, bone-marrow-derived, granule-containing immune cells that are found in all connective tissue and mucosal environments and in the peripheral and central nervous systems. Mast cells are able to phagocytose, process and present antigens as effectively as macrophages. The pr...

  16. Solar Array Mast Imagery Discussion for ISIW

    Science.gov (United States)

    Kilgo, Gary

    2017-01-01

    SAW Mast inspection background: In 2012, NASA's Flight Safety Office requested the Micro Meteoroid and Orbital Debris (MMOD) office determine the probability of damage to the Solar Array Wing (SAW) mast based on the exposure over the life time of the ISS program. As part of the risk mitigation of the potential MMOD strikes. ISS Program office along with the Image Science and Analysis Group (ISAG) began developing methods for imaging the structural components of the Mast.

  17. Mast cells in pathological and surgical scars

    OpenAIRE

    Beer, T; Baldwin, H; West, L; Gallagher, P.; Wright, D.

    1998-01-01

    AIM—To investigate the role of mast cells in surgical and pathological scar reactions by their identification and quantification using immunohistochemistry.
METHODS—Surgical scars and pathological scar reactions were stained immunohistochemically for tryptase to identify mast cells. These were quantified in the scar tissue and surrounding dermis. Statistical analyses were performed to test the hypothesis that mast cell numbers were different in the varying types of scar reaction.
RESULTS—A si...

  18. Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias.

    Science.gov (United States)

    Regauer, Sigrid; Eberz, Barbara; Beham-Schmid, Christine

    2015-05-01

    Mast cell infiltrates in tissues of vulvodynia are common, but they have not been characterized for criteria of neoplastic mast cell disease or correlated with patient's concomitant diseases associated with increased mast cells. Formalin-fixed specimens of 35 patients with vulvodynia were evaluated immunohistochemically with antibodies to CD 3,4,8,20,117c and human mast cell tryptase, and for WHO-criteria of neoplastic mastocytosis (>25% spindled mast cell, CD25 expression, point mutations of the c-kit gene (D816V), and chronically elevated serum tryptase levels). Only 20/35 specimens showed a T-lymphocyte dominant inflammatory infiltrate on HE-stained sections, but all showed mast cells. 4/35 biopsies showed 60 mast cells/mm(2) (average 80/mm(2) ). Control tissue contained typically mast cell rich biopsies with >40 mast cells/mm(2) were classified as a secondary mast cell disorder reflecting an activated immune system in 75% of vulvodynia patients. Patients with increased mast cells may benefit from medical therapy targeting mast cells.

  19. Effects of the layered curriculum on student’s success, permanence and attitudes in Science and Technology Course

    Directory of Open Access Journals (Sweden)

    Mehmet Nuri Gömleksiz

    2012-11-01

    Full Text Available This study aims to determine the effects of the layered curriculum on students’ achievement, permanence and attitudes towards Science and Technology course. The research was conducted with two classes including an experimental and a control class at 6th grade of Elazig İstiklal Primary School in 2009-2010 academic year. Mixed research model that utilize both quantitative and qualitative research methods together was preferred in this research. To that end, achievement test and attitude scale were used as the data collection tool and observations and interviews were performed. While the course was lectured using the layered curriculum for the experimental group, the traditional teaching method was used for the control group. While average difficulty of the test was found to be 0.55, KR-20 value was 0.86. While KMO value of the scale was measured as .837, Bartlett test result was calculated to be 1544.231. The Cronbach Alpha reliability coefficient of the scale was found to be α= 0.898. Spearman-Brown reliability coefficient was calculated to be .860, Gutmann Split-Half reliability coefficient was found to be .855 olarak bulunmuştur. For the analysis of the quantitative data, Levene’s test, independent groups t-test, paired groups t test and MWU test were used. The analysis of the qualitative data was interpreted using NVIVO. As a result of the research, it was concluded that the layered curriculum affected favorably students’ achievements and their attitudes towards the course. When the findings obtained from the results of the interviews and observations were evaluated, it was found that those findings were parallel with the findings obtained from the achievement test and attitude scale. To this end, some recommendations have been developed and presented.

  20. Effects of the layered curriculum on student’s success, permanence and attitudes in Science and Technology Course

    Directory of Open Access Journals (Sweden)

    Mehmet Nuri Gömleksiz

    2012-11-01

    Full Text Available This study aims to determine the effects of the layered curriculum on students’ achievement, permanence and attitudes towards Science and Technology course.  The research was conducted with two classes including an experimental and a control class at 6th grade of Elazig İstiklal Primary School in 2009-2010 academic year. Mixed research model that utilize both quantitative and qualitative research methods together was preferred in this research. To that end, achievement test and attitude scale were used as the data collection tool and observations and interviews were performed. While the course was lectured using the layered curriculum for the experimental group, the traditional teaching method was used for the control group. While average difficulty of the test was found to be 0.55, KR-20 value was 0.86. While KMO value of the scale was measured as .837, Bartlett test result was calculated to be 1544.231. The Cronbach Alpha reliability coefficient of the scale was found to be α= 0.898. Spearman-Brown reliability coefficient was calculated to be .860, Gutmann Split-Half reliability coefficient was found to be .855 olarak bulunmuştur. For the analysis of the quantitative data, Levene’s test, independent groups t-test, paired groups t test and MWU test were used. The analysis of the qualitative data was interpreted using NVIVO. As a result of the research, it was concluded that the layered curriculum affected favorably students’ achievements and their attitudes towards the course. When the findings obtained from the results of the interviews and observations were evaluated, it was found that those findings were parallel with the findings obtained from the achievement test and attitude scale. To this end, some recommendations have been developed and presented.

  1. DETERMINING THE TEACHERS’ VIEWS ON THE APPLICABILITY OF THE TECHNOLOGY DESIGN OBJECTIVES IN 9th GRADE PHYSICS CURRICULUM

    Directory of Open Access Journals (Sweden)

    Hakan Şevki AYVACI

    2012-03-01

    Full Text Available Recently, as technological developments have been increasing, people need to have more knowledge and learn the ways of acquisition of knowledge. To follow the technological developments requires being a scientifically literate person (Kortland, 2010. Because of this reason, new reforms are put into practice in all areas as well as in science education. And scientific literacy has become a major aim of science education. Scientific literacy is defined as the capacity to use scientific knowledge, to identify questions and to draw evidence-based conclusions in order to understand and help make decisions about the natural world and the changes made to it through human activity. Scientific literacy is a major aim in science education but which approach could be effective at developing scientific literacy? Science educators developed context-based approach to integrate scientific knowledge and real life events, and the designed their After the curriculum changes in many countries, Turkey has also changed the physics curriculum. In schools, physics books which are based on context-based approach are being used as reference books. The reasons of changing teaching curriculums may be ‘the failure to make students scientifically literate’, ‘a weak link between science/physics and daily life’, ‘a negative image of the subject such as difficulty and requirement of mathematics’, and ‘a decrease in students’ motivation around high content overload’. Context-based approach aims to develop and sustain a sense of wonder and curiosity in young people about the natural world. At the same time, a context can make students connect scientific knowledge to real life (Colburn, 2000; Saka, 2006. The students are required to induce meanings by using contexts, thus justifying a ‘need-to-know’ approach to content. Thus, students’ interest and positive attitudes towards physics have been increased (Campbell vd., 2000; Bennett ve Lubben, 2006; Bultev

  2. Multi-Axial Simulation Table (MAST)

    Data.gov (United States)

    Federal Laboratory Consortium — The MAST delivers an extensive array of testing applications providing rapid, flexible and reliable analysis for ground vehicle components and subassemblies. Using...

  3. Multi-Axial Simulation Table (MAST)

    Data.gov (United States)

    Federal Laboratory Consortium — The MAST delivers an extensive array of testing applications providing rapid, flexible and reliable analysis for ground vehicle components and subassemblies. Using...

  4. Mast cells and cancer: enemies or allies?

    Science.gov (United States)

    Dyduch, Grzegorz; Kaczmarczyk, Karolina; Okoń, Krzysztof

    2012-03-01

    Mast cells are a component of cancer microenvironment the role of which is complex and poorly understood. Mast cells promote cancer growth by stimulation of neoangiogenesis, tissue remodeling and by modulation of the host immune response. The mediators of cancer promotion include protease-activated receptors, mitogen activated protein kinases, prostaglandins and histamine. Histamine may induce tumor proliferation and immunosuppression through H1 and H2 receptors, respectively. The mast cell-derived modulators of immune response include also interleukin 10 (IL-10), tumor necrosis factor α (TNF-α) and CD30L. Possibly stimulation of angiogenesis is the most important. Mast cells release potent proangiogenic factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor β (TGF-β), TNF- α and IL-8, and mast cells' enzymes, like metaloproteinases (MMPs), tryptase and chymase participate in vessels' formation. The anti-cancer actions of mast cells include direct growth inhibition, immunologic stimulation, inhibition of apoptosis and decreased cell mobility; the mediators of these processes include chymase, tryptase, TNF-α, IL-1 and IL-6. The very same mediators may exert both pro- or anti-cancer effects depending on concentration, presence of cofactors or location of secreting cells. In fact, peri- and intra-tumoral mast cells may have dissimilar effects. Understanding of the role of mast cells in cancer could lead to improved prognostication and development of therapeutic methods targeting the mast cells.

  5. Paul Ehrlich's mastzellen: a historical perspective of relevant developments in mast cell biology.

    Science.gov (United States)

    Ghably, Jack; Saleh, Hana; Vyas, Harsha; Peiris, Emma; Misra, Niva; Krishnaswamy, Guha

    2015-01-01

    Following the discovery of mast cells (or mastzellen) by the prolific physician researcher, Paul Ehrlich, many advances have improved our understanding of these cells and their fascinating biology. The discovery of immunoglobulin E and receptors for IgE and IgG on mast cells heralded further in vivo and in vitro studies, using molecular technologies and gene knockout models. Mast cells express an array of inflammatory mediators including tryptase, histamine, cytokines, chemokines, and growth factors. They play a role in many varying disease states, from atopic diseases, parasitic infections, hematological malignancies, and arthritis to osteoporosis. This review will attempt to summarize salient evolving areas in mast cell research over the last few centuries that have led to our current understanding of this pivotal multifunctional cell.

  6. Marginalization of Socioscientific Material in Science-Technology-Society Science Curricula: Some Implications for Gender Inclusivity and Curriculum Reform

    Science.gov (United States)

    Hughes, Gwyneth

    2000-05-01

    Science education reformers have argued that presenting science in the abstract is neither motivating nor inclusive of the majority of students. Science-technology-society (STS) curricula that give science an accessible social context have developed in response, but controversy surrounds the extent to which students should be introduced to socioscientific debate. Using material from a case study of Salters' Advanced Chemistry in the United Kingdom, this article demonstrates how socioscientific material is marginalized through the structures and language of syllabus texts and through classroom practices. This means students are unlikely to engage with socioscientific aspects in their course. Socioscientific content is gendered through association with social concerns and epistemological uncertainty, and because gender is asymmetric, socioscience is devalued with respect to the masculinity of abstract science. Teachers fear that extensive coverage of socioscience devalues the curriculum, alienates traditional science students and jeopardizes their own status as gatekeepers of scientific knowledge. Thus, although STS curricula such as Salters' offer potential for making science more accessible, the article concludes that greater awareness of, and challenges to, gender binaries could result in more effective STS curriculum reform.

  7. Where's my robot? Integrating human technology relations in the design curriculum

    NARCIS (Netherlands)

    Eggink, Wouter; Bohemia, E.; Eger, A.; Eggink, W.; Kovacevic, A.; Parkinson, B; Wits, W.W.

    2014-01-01

    In today’s society, and in almost every forecast for the future, technology development plays a major role. From theories in Science & Technology Studies we learn that the development of new technology cannot be meaningful unless there are users that successfully adapt the products and services to t

  8. Incorporating nanoscale science and technology into secondary school curriculum: Views of nano-trained science teachers

    Directory of Open Access Journals (Sweden)

    Antti Laherto

    2011-09-01

    Full Text Available The growing societal significance of nanoscience and nanotechnology (NST entails needs for addressing these topics in school curricula. This study lays groundwork for responding to those needs in Finland. The purpose was to analyse the appropriateness of NST for secondary school curriculum contents. First, a week-long in-service teacher training course was arranged on content knowledge of NST. After attending the course, 23 experienced science teachers were surveyed regarding their views on the educational significance of these issues, and on prospects for including them into the curriculum. A questionnaire with open-ended questions was used. Qualitative content analysis of the responses revealed that the respondents considered NST as desirable contents for secondary school, but arranging instruction is problematic. The teachers emphasised the educational significance of many applications, scientific principles and ethical issues related to NST. The outcomes are discussed with reference to recent studies on teachers’ barriers and educational concerns regarding NST.

  9. The Importance of Introducing a Course on Information and Communication Technologies for Development into the Information Technology Curriculum

    Science.gov (United States)

    Al-Ahmad, Walid

    2010-01-01

    This paper studies the role and the importance of Information and Communication Technologies for Development (ICT4D) education in Information Technology (IT) programs. The research included the students who attended an ICT4D course at NYiT Amman Campus in the academic years of 2006 to 2009. Data were collected through two questionnaires developed…

  10. The Impact of High School Principal's Technology Leadership on the Sustainability of Corporate Sponsored Information Communication Technology Curriculum

    Science.gov (United States)

    Gottwig, Bruce Ryan

    2013-01-01

    The proliferation of information communication technology (ICT) has placed educational institutions in the forefront in educating and training students as skilled consumers, engineers, and technicians of this widely used technology. Corporations that develop and use ICT are continually building a skilled workforce; however, because of the growth…

  11. Farm Crop Production Technology: Field and Forage Crop and Fruit and Vine Production Options. A Suggested 2-Year Post High School Curriculum.

    Science.gov (United States)

    Division of Vocational and Technical Education, BAVT.

    Prepared by a junior college under contract with the Office of Education, the curriculum materials are designed to assist school administrators, advisory committees, supervisors, and teachers in developing or evaluating postsecondary programs in farm crop production technology. Information was gathered by visits to the important farm regions and…

  12. Students' Conceptions of Sound Waves Resulting from the Enactment of a New Technology-Enhanced Inquiry-Based Curriculum on Urban Bird Communication

    Science.gov (United States)

    Houle, Meredith E.; Barnett, G. Michael

    2008-01-01

    The emerging field of urban ecology has the potential to engage urban youth in the practices of scientists by studying a locally relevant environmental problem. To this end, we are developing curriculum modules designed to engage students in learning science through the use of emerging information technology. In this paper, we describe the impact…

  13. Gender Effects on Curriculum Elements Based on Mathematics and Science and Technology Teachers' Opinions: A Meta-Analysis for Turkish Studies

    Science.gov (United States)

    Küçüktepe, Seval Eminoglu; Yildiz, Nilgün

    2016-01-01

    The purpose of this study is to investigate the gender effect on elementary mathematics and science and technology teachers' opinions regarding curriculum elements which are objectives, content, learning situation and evaluation. Meta-analysis was used in order to analyze data. Two articles, 11 master and one doctorate thesis which were conducted…

  14. Mississippi Curriculum Framework for Horticulture Technology Cluster (Program CIP: 01.0601--Horticulture Serv. Op. & Mgmt., Gen.) (Program CIP: 01.0605--Landscaping Op. & Mgmt.). Postsecondary Programs.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the horticulture technology programs cluster. Presented in the introductory section are a framework of programs and courses, description of the programs, and suggested course sequences for…

  15. The Delphi Technique in Identifying Learning Objectives for the Development of Science, Technology and Society Modules for Palestinian Ninth Grade Science Curriculum

    Science.gov (United States)

    Abualrob, Marwan M. A.; Daniel, Esther Gnanamalar Sarojini

    2013-01-01

    This article outlines how learning objectives based upon science, technology and society (STS) elements for Palestinian ninth grade science textbooks were identified, which was part of a bigger study to establish an STS foundation in the ninth grade science curriculum in Palestine. First, an initial list of STS elements was determined. Second,…

  16. The Implementation of a Geospatial Information Technology (GIT)-Supported Land Use Change Curriculum with Urban Middle School Learners to Promote Spatial Thinking

    Science.gov (United States)

    Bodzin, Alec M.

    2011-01-01

    This study investigated whether a geospatial information technology (GIT)-supported science curriculum helped students in an urban middle school understand land use change (LUC) concepts and enhanced their spatial thinking. Five 8th grade earth and space science classes in an urban middle school consisting of three different ability level tracks…

  17. NATIVE-It's Your Game: Adapting a Technology-Based Sexual Health Curriculum for American Indian and Alaska Native youth.

    Science.gov (United States)

    Shegog, Ross; Craig Rushing, Stephanie; Gorman, Gwenda; Jessen, Cornelia; Torres, Jennifer; Lane, Travis L; Gaston, Amanda; Revels, Taija Koogei; Williamson, Jennifer; Peskin, Melissa F; D'Cruz, Jina; Tortolero, Susan; Markham, Christine M

    2017-04-01

    Sexually transmitted infection (STI) and birth rates among American Indian/Alaska Native (AI/AN) youth indicate a need for effective middle school HIV/STI and pregnancy prevention curricula to delay, or mitigate, the consequences of early sexual activity. While effective curricula exist, there is a dearth of curricula with content salient to AI/AN youth. Further, there is a lack of sexual health curricula that take advantage of the motivational appeal, reach, and fidelity of communication technology for this population, who are sophisticated technology users. We describe the adaptation process used to develop Native It's Your Game, a stand-alone 13-lesson Internet-based sexual health life-skills curriculum adapted from an existing promising sexual health curriculum, It's Your Game-Tech (IYG-Tech). The adaptation included three phases: (1) pre-adaptation needs assessment and IYG-Tech usability testing; (2) adaptation, including design document development, prototype programming, and alpha testing; and (3) post-adaption usability testing. Laboratory- and school-based tests with AI/AN middle school youth demonstrated high ratings on usability parameters. Youth rated the Native IYG lessons favorably in meeting the needs of AI/AN youth (54-86 % agreement across lessons) and in comparison to other learning channels (57-100 %) and rated the lessons as helpful in making better health choices (73-100 %). Tribal stakeholders rated Native IYG favorably, and suggested it was culturally appropriate for AI/AN youth and suitable for implementation in tribal settings. Further efficacy testing is indicated for Native IYG, as a potential strategy to deliver HIV/STI and pregnancy prevention to traditionally underserved AI/AN middle school youth.

  18. Vibration Measurements on the Frejlev Mast

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Hansen, Lars Pilegaard

    The present report presents full-scale measurements on the Frejlev-mast which is a 200 meter hight guyed steel mast located 10 km. from Aalborg. The goal of the research was to investigate various techniques which could be used to estimate cable forces from vibration measurements. The cables...

  19. How to enhance nursing students' intention to use information technology: the first step before integrating it in nursing curriculum.

    Science.gov (United States)

    Gonen, Ayala; Sharon, Dganit; Offir, Ana; Lev-Ari, Lilac

    2014-06-01

    Today, in the 21st century, information technology has an important and critical role in the healthcare delivery system. Nursing educators already know and understand that they should integrate nursing informatics into the nursing curriculum to prepare future nurses for the new world of information technology. However, as of now, the core program of nursing studies in Israel does not put an emphasis on the skills required to properly use nursing informatics. The present research is the first step toward achieving this target by recognizing the importance of the human factor. The main goal is to examine the correlation between nursing students' attitudes and a number of variables: self-efficacy, threat, challenge, and innovativeness. This quantitative study used a convenience sample of nursing students in a bachelor's degree program at a large academic center in central Israel. Results show significant positive correlations between nursing students' attitudes to computer use and self-efficacy, a sense of challenge in using a computer, a sense of threat in using a computer, and previous experience with computers. The insights of these results will benefit nursing educators by helping them find creative ways to expose the students to the world of information technology and to improve the quality of future nurses.

  20. Guided Discovery, Visualization, and Technology Applied to the New Curriculum for Secondary Mathematics.

    Science.gov (United States)

    Smith, Karan B.

    1996-01-01

    Presents activities which highlight major concepts of linear programming. Demonstrates how technology allows students to solve linear programming problems using exploration prior to learning algorithmic methods. (DDR)

  1. Guided Discovery, Visualization, and Technology Applied to the New Curriculum for Secondary Mathematics.

    Science.gov (United States)

    Smith, Karan B.

    1996-01-01

    Presents activities which highlight major concepts of linear programming. Demonstrates how technology allows students to solve linear programming problems using exploration prior to learning algorithmic methods. (DDR)

  2. Ion channels regulating mast cell biology.

    Science.gov (United States)

    Ashmole, I; Bradding, P

    2013-05-01

    Mast cells play a central role in the pathophysiology of asthma and related allergic conditions. Mast cell activation leads to the degranulation of preformed mediators such as histamine and the secretion of newly synthesised proinflammatory mediators such as leukotrienes and cytokines. Excess release of these mediators contributes to allergic disease states. An influx of extracellular Ca2+ is essential for mast cell mediator release. From the Ca2+ channels that mediate this influx, to the K+ , Cl- and transient receptor potential channels that set the cell membrane potential and regulate Ca2+ influx, ion channels play a critical role in mast cell biology. In this review we provide an overview of our current knowledge of ion channel expression and function in mast cells with an emphasis on how channels interact to regulate Ca2+ signalling.

  3. Competency Standards for Bachelor of Industrial Technology Graduates for the Construction Industry in Region IV-A: Inputs For Curriculum Enhancement

    Directory of Open Access Journals (Sweden)

    George P. Compasivo

    2015-12-01

    Full Text Available The main objective of this study was to develop competency standards for Industrial Technology graduates for employment in the construction industry in Region IV-A, Philippines. It specifically identified the basic and core competency standards for industrial technology and determined the degree of importance of competencies needed in the construction industry sector. The study identified 28 common competencies for three areas of specializations in industrial technology namely: electrical, civil and drafting technology. There were 39 core competencies for electrical, 31 for drafting and 38 items for civil technology. A total of 50 panel of experts were carefully selected using the purposive sampling as respondents in the study. Experts are selected based on their technical know-how or proficiency and currently practicing their line of profession in the construction industry. The study used the descriptive-developmental method of research. The Delphi technique was applied to determine if the competency under investigation reached the general agreement of opinions by the panel of experts involved. The findings implied that the newly developed competency standards were good input for curriculum enhancement in the area of civil, drafting and electrical technology. The study recommended the newly developed competencies may be followed by the faculty in the course they teach and the new competency items suggested by the panel of experts for inclusion in the curriculum for the three areas of specializations may be considered during the curriculum revision.

  4. A research feasibility study proposal for conducting experimental research in curriculum sharing via Communications Technology Satellite among institutions having large minority enrollments

    Science.gov (United States)

    Williams, L., Jr.

    1978-01-01

    The applicability of the tele-conference method of curriculum sharing as well as the sharing of scientific research results between universities and industrial organizations was evaluated in relation to other techniques and methods. Ten universities cooperated with NC A&T State University in an effort to increase the number of minority scientists and engineers in the USA via the utilization of the communication features of satellites. Research activities, experiments and studies in curriculum sharing are described as well as the techniques, interconnections and equipment utilized. Suggested methods and recommendations for a continuation of innovative applications of satellite technology in higher education at NC A&T State University are included.

  5. Building a Four Year Post-Secondary Curriculum in Educational Science and Technology.

    Science.gov (United States)

    Plomp, Tjeerd; Verhagen, Plon

    This report begins by providing background information on educational technology in the Netherlands, differences between a four-year program in the Netherlands and undergraduate programs in the United States, and the structure of Dutch university programs. The need for a Department of Educational Science and Technology at the Twente University of…

  6. A Study of the Awareness Level of Electric Vehicle Technology in California Community College Automotive Curriculums.

    Science.gov (United States)

    Keyzer, James

    California automotive technician programs were surveyed regarding their awareness of the impact that mandates of the Clean Air Act would have on their automotive technology programs. A questionnaire was sent to 100 California community colleges with an automotive technology program; 49 usable questionnaires were returned. A possible byproduct of…

  7. The Teacher as Re-Designer of Technology Integrated Activities for an Early Literacy Curriculum

    Science.gov (United States)

    Cviko, Amina; McKenney, Susan; Voogt, Joke

    2013-01-01

    Though popular among children outside of school, Dutch teachers often struggle to offer technology integrated activities in the kindergarten classroom. Because involving teachers in development of technology integrated activities can support their implementation, this study examines teachers in the role of re-designing such activities. Two case…

  8. Technological Pedagogical Content Knowledge in Teacher Education: In Search of a New Curriculum

    Science.gov (United States)

    Tondeur, Jo; Roblin, Natalie Pareja; van Braak, Johan; Fisser, Petra; Voogt, Joke

    2013-01-01

    The aim of this study was to explore the ways in which teacher education institutions (TEI) prepare pre-service teachers for integrating information and communication technology (ICT) in their classroom practise. Specifically, a multiple case study was conducted to examine the ways in which the development of technological pedagogical content…

  9. A Case for the Nationwide Inclusion of Engineering in the K-12 Curriculum via Technology Education

    Science.gov (United States)

    Pinelli, Thomas E.; Haynie, W. James, III

    2010-01-01

    This paper resulted from discussions between a technology teacher educator and a colleague who has served in various education outreach roles with NASA. The basis of the paper was developed by the NASA director and two engineers, one serving with NASA and the other with the National Institute of Aerospace. The technology teacher educator read the…

  10. Technological Pedagogical Content Knowledge in Teacher Education: In Search of a New Curriculum

    Science.gov (United States)

    Tondeur, Jo; Roblin, Natalie Pareja; van Braak, Johan; Fisser, Petra; Voogt, Joke

    2013-01-01

    The aim of this study was to explore the ways in which teacher education institutions (TEI) prepare pre-service teachers for integrating information and communication technology (ICT) in their classroom practise. Specifically, a multiple case study was conducted to examine the ways in which the development of technological pedagogical content…

  11. Electrical Power Engineering Technology: Designing a New Two-Plus-Two Curriculum

    Science.gov (United States)

    Burson, Jack

    1978-01-01

    An upper-division two-year program in electrical power engineering technology developed at Oklahoma State University is described. The typical two-plus-two program in mechanical, electronics, electromechanical, or other related technologies consists of two years of study at the associate level followed by two years at the bachelor's level. (MF)

  12. The mast on the house

    DEFF Research Database (Denmark)

    Landberg, L.

    2000-01-01

    An often encountered problem when preparing the basic input data for a wind atlas study is the correction for the influence of the house or hut on which the mast—whose data form the basis of this wind atlas—is placed. The article will describe an experiment where this problem has been addressed....... The knowledge gained will be used to give guidelines as to the use of the WAsP program to correct the observations. Should the house/hut simply be treated as an extension of the mast, should the house/hut be treated as a hill with speed-up effects, or should the house/hill be ignored completely? The paper...... will show that the house/hut should indeed be treated as a hill with speed-up effects. Placing meteorological masts on houses or huts is common practice in quite a few countries in the world. The problem is therefore one which most people involved in detailed wind resource assessment will face sooner...

  13. 2008 Mississippi Curriculum Framework: Postsecondary Radiologic Technology. (Program CIP: 51.0911 - Radiologic Technology/Science - Radiographer)

    Science.gov (United States)

    Armstrong, David; Cochran, Timothy; Compton, Steve; Davis, Jennifer; Edgerton, Seena Shazowee; Kisner, Christie; Lewis, Judy; Sartin, Billie Faye; Shell, Deborah

    2008-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  14. 2009 Mississippi Curriculum Framework: Postsecondary Nuclear Medicine Technology. (Program CIP: 51.0905 - Nuclear Medical Technology/Technologist)

    Science.gov (United States)

    Boney, Linda; Lee, Joanne; Pyles, Alice; Whitfield, Stacy

    2009-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  15. Educational Scholarship and Technology: Resources for a Changing Undergraduate Medical Education Curriculum.

    Science.gov (United States)

    Kyle, Brandon N; Corral, Irma; John, Nadyah Janine; Shelton, P G

    2017-06-01

    Returning to the original emphasis of higher education, universities have increasingly recognized the value and scholarship of teaching, and medical schools have been part of this educational scholarship movement. At the same time, the preferred learning styles of a new generation of medical students and advancements in technology have driven a need to incorporate technology into psychiatry undergraduate medical education (UGME). Educators need to understand how to find, access, and utilize such educational technology. This article provides a brief historical context for the return to education as scholarship, along with a discussion of some of the advantages to this approach, as well as several recent examples. Next, the educational needs of the current generation of medical students, particularly their preference to have technology incorporated into their education, will be discussed. Following this, we briefly review the educational scholarship of two newer approaches to psychiatry UGME that incorporate technology. We also offer the reader some resources for accessing up-to-date educational scholarship for psychiatry UGME, many of which take advantage of technology themselves. We conclude by discussing the need for promotion of educational scholarship.

  16. Into the Curriculum. Art: Making Snowmen; Health: It's Flu Season!; Language Arts/Technology: Choices; Reading/Language Arts: Getting To Know Young Adult Authors; Science: It's All in the Weather; Social Studies: Middle Ages Daily Life.

    Science.gov (United States)

    D'Amato, Laura; Small, Esther

    2003-01-01

    Provides six fully developed library media activities that are designed for use with special curriculum units in art, health, language arts, technology, reading, science, and social studies. Library media skills, curriculum objectives, grade levels, resources, instructional roles, procedures, evaluation, and follow-up are described for each…

  17. 2008 Mississippi Curriculum Framework: Postsecondary Pharmacy Technology. (Program CIP: 51.0805 - Pharmacy Technician/Assistant)

    Science.gov (United States)

    Juergens, John; Sanders, Marsha

    2008-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  18. Towards a Gender Inclusive Information and Communications Technology Curriculum: A Perspective from Graduates in the Workforce

    Science.gov (United States)

    Koppi, Tony; Sheard, Judy; Naghdy, Fazel; Edwards, Sylvia L.; Brookes, Wayne

    2010-01-01

    An online survey was conducted of recent information and communications technology (ICT) graduates from 21 Australian universities. A range of abilities including personal/interpersonal, cognitive, business and technical were examined in relation to importance in the workplace and university preparation of those abilities. In addition, a set of…

  19. Integration of Technology Education in Basic and General Education Curriculum in Asia-Pacific Countries.

    Science.gov (United States)

    Basu, C. K.

    Despite the expansion of technical-vocational education and training (TVET) in nearly all Asia-Pacific countries during the past 10-15 years, many of the region's policymakers have called for greater and more effective integration of technical-vocational components in basic and general education curricula. The idea that technology education should…

  20. Perspectives on Pupil Creativity in Design and Technology in the Lower Secondary Curriculum in England

    Science.gov (United States)

    Rutland, Marion; Barlex, David

    2008-01-01

    This paper is based on work carried out as part of a research study into the professional practices of secondary design and technology teachers in England. It focused on fostering creativity or teaching for creativity as defined by the Robinson Report (1999, All our futures: creativity, culture and education. London: Department for Education and…

  1. 2011 Mississippi Curriculum Framework: Postsecondary Dental Hygiene Technology. (Program CIP: 51.0602 - Dental Hygienist)

    Science.gov (United States)

    Alexander, Nick; Dunn, Catherine; Hill, Stanley; Lindsay, William

    2011-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  2. Positioning Education in the Information Society: The Transnational Diffusion of the Information and Communication Technology Curriculum

    Science.gov (United States)

    Ham, Seung-Hwan; Cha, Yun-Kyung

    2009-01-01

    One of the most distinctive qualities that characterize present-day society is the social fact that people are shifting to the information age. In recent years, they have witnessed remarkable developments in information and communication technology (ICT), in which microelectronics, computers, and telecommunications have converged. Transnational…

  3. Investigation on the Inclusion of Socio-Scientific Acquisitions in Curriculum of Science and Technology Lesson

    Science.gov (United States)

    Guler, Mutlu Pinar Demirci

    2013-01-01

    According to its definition, socio-scientific subjects emerge during scientific and technologic developments. Besides information, attitude and value constraints are effective in decision-making processes and thus there is no consensus on socio-scientific subjects yet and it leads to social discussions. These subjects comprise decision making…

  4. 2010 Mississippi Curriculum Framework: Postsecondary Paralegal Technology. (Program CIP: 22.0302 - Legal Assistant/Paralegal)

    Science.gov (United States)

    Cox, Janet; Dinkins, Shivochie L.; Dozier, Darleen; Ford, Kathryn; Hinton, Amy; McDavid, Stephan; Phifer-Starks, Kim D.; Winston, Felicia

    2010-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  5. 2006 Mississippi Curriculum Framework: Postsecondary Paralegal Technology. (Program CIP: 22.0302 - Legal Assistant/Paralegal)

    Science.gov (United States)

    Hinton, Amy; Phifer-Starks, Kim D.; Nelson, LaTricia

    2006-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  6. Selection of Server-Side Technologies for an E-Business Curriculum

    Science.gov (United States)

    Sandvig, J. Christopher

    2007-01-01

    The rapid growth of e-business and e-commerce has made server-side programming an increasingly important topic in information systems (IS) and computer science (CS) curricula. This article presents an overview of the major features of several popular server-side programming technologies and discusses the factors that influence the selection of…

  7. Technology in the School Curriculum: The Moral Dimension of Making Things.

    Science.gov (United States)

    Olson, John

    1997-01-01

    Criticizes the compartmentalization of educational practices into a hierarchy of general, vocational, and social. Argues for a more holistic integration of technology, vocation, and education reflecting a vision of lifelong learning and meaningful work. Discusses examples of this including the Scandinavian tradition of "Sloyd"…

  8. From the Laboratory to the Classroom: A Technology-Intensive Curriculum for Functions and Graphs.

    Science.gov (United States)

    Magidson, Susan

    1992-01-01

    Addresses the challenges, risks, and rewards of teaching about linear functions in a technology-rich environment from a constructivist perspective. Describes an algebra class designed for junior high school students that focuses of the representations and real-world applications of linear functions. (MDH)

  9. Using Anchored Instruction to Teach Preservice Teachers to Integrate Technology in the Curriculum

    Science.gov (United States)

    Kariuki, Mumbi; Duran, Mesut

    2004-01-01

    This case study addresses the use of the "anchored instruction approach" to restructure educational computing courses to enhance future teachers' learning of technology applications in the classroom. A cohort group of 22 preservice teachers from a typical teacher education institution in Southeastern Ohio was involved in the study. The…

  10. 2009 Mississippi Curriculum Framework: Postsecondary Occupational Safety and Health Technology. Program CIP: 15.0701

    Science.gov (United States)

    Flowers, Walter M.

    2009-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  11. FOOD PROCESSING TECHNOLOGY, A SUGGESTED 2-YEAR POST HIGH SCHOOL CURRICULUM.

    Science.gov (United States)

    KNOEBEL, ROBERT M.; AND OTHERS

    ADMINISTRATORS, ADVISORY COMMITTEES, SUPERVISORS, AND TEACHERS MAY USE THIS GUIDE IN PLANNING AND DEVELOPING NEW PROGRAMS OR EVALUATING EXISTING PROGRAMS IN POST-HIGH SCHOOL FOOD PROCESSING TECHNOLOGY. BASIC MATERIALS WERE PREPARED BY THE STATE UNIVERSITY OF NEW YORK AGRICULTURAL AND TECHNICAL COLLEGE AT MORRISVILLE AND FINAL PREPARATION WAS…

  12. Selection of Server-Side Technologies for an E-Business Curriculum

    Science.gov (United States)

    Sandvig, J. Christopher

    2007-01-01

    The rapid growth of e-business and e-commerce has made server-side programming an increasingly important topic in information systems (IS) and computer science (CS) curricula. This article presents an overview of the major features of several popular server-side programming technologies and discusses the factors that influence the selection of…

  13. 2011 Mississippi Curriculum Framework: Postsecondary Paramedic. (Program CIP: 51.0904 - Emergency Medical Technology/Technician)

    Science.gov (United States)

    Briscoe, Lisa; Bryant, Katrina; Deschamp, Clyde; Galtelli, Mark; Glasson, Kristi; Hall, David; Hood, Brenda; Mahaffey, Libby; McBryde, John; Read, John; Shirley, Gary

    2011-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  14. Aesthetics in Young Children's Lives: From Music Technology Curriculum Perspective

    Science.gov (United States)

    Ko, Chia-Hui; Chou, Mei-Ju

    2013-01-01

    Music technology is a term commonly used to refer to electronic form of the musical arts, particularly devices and computer software that enable the facilitation, playback, recording, composition, storage, and performance of various musical compositions. There has been a growing awareness of the importance of aesthetics in early childhood…

  15. 2009 Mississippi Curriculum Framework: Postsecondary Respiratory Care Technology. (Program CIP: 51.0908 - Respiratory Care Practitioner)

    Science.gov (United States)

    Anderson, Lori; Brooks, Anthony; Miller, Shirley; Newell, Jim; Prince, Beverly; Smith, Jacqueline; Smith, Lynn; Ware, Chris

    2009-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  16. Struggling for a New Identity: A Critique of the Curriculum Research Effort in Technology Education.

    Science.gov (United States)

    Zuga, Karen F.

    Historically, technology education evolved from several strands: Bacon's realism, Pestalozzi's belief in the practical application of knowledge, Rousseau's naturalism, Herbart's sense realism, Dewey's progressive and social reconstructionist thinking, and the influence of vocationalism. The mainstream practice of industrial arts was more a study…

  17. Towards a Gender Inclusive Information and Communications Technology Curriculum: A Perspective from Graduates in the Workforce

    Science.gov (United States)

    Koppi, Tony; Sheard, Judy; Naghdy, Fazel; Edwards, Sylvia L.; Brookes, Wayne

    2010-01-01

    An online survey was conducted of recent information and communications technology (ICT) graduates from 21 Australian universities. A range of abilities including personal/interpersonal, cognitive, business and technical were examined in relation to importance in the workplace and university preparation of those abilities. In addition, a set of…

  18. Science, Technology, Engineering, and Mathematics (STEM) Curriculum and Seventh Grade Mathematics and Science Achievement

    Science.gov (United States)

    James, Jamie Smith

    2014-01-01

    The purpose of this quantitative research study was to evaluate to what degree Science, Technology, Engineering and Mathematics (STEM) education influenced mathematics and science achievement of seventh grade students in one Middle Tennessee school district. This research used an independent samples t test at the a = 0.05 level to evaluate…

  19. Developing Health Information Technology (HIT) Programs and HIT Curriculum: The Southern Polytechnic State University Experience

    Science.gov (United States)

    Zhang, Chi; Reichgelt, Han; Rutherfoord, Rebecca H.; Wang, Andy Ju An

    2014-01-01

    Health Information Technology (HIT) professionals are in increasing demand as healthcare providers need help in the adoption and meaningful use of Electronic Health Record (EHR) systems while the HIT industry needs workforce skilled in HIT and EHR development. To respond to this increasing demand, the School of Computing and Software Engineering…

  20. Positioning Education in the Information Society: The Transnational Diffusion of the Information and Communication Technology Curriculum

    Science.gov (United States)

    Ham, Seung-Hwan; Cha, Yun-Kyung

    2009-01-01

    One of the most distinctive qualities that characterize present-day society is the social fact that people are shifting to the information age. In recent years, they have witnessed remarkable developments in information and communication technology (ICT), in which microelectronics, computers, and telecommunications have converged. Transnational…

  1. Computers in the Mathematics Curriculum.

    Science.gov (United States)

    Ediger, Marlow

    This paper examines ways that mathematics teachers and supervisors can use computers in a quality mathematics curriculum in a school setting. Teachers and supervisors continually need to appraise the present mathematics curriculum and make necessary changes. A modern mathematics curriculum makes much use of technology. Society emphasizes heavy use…

  2. Science and Mathematics as part of practical projects in technology and design: An analysis of challenges in realising the curriculum in Norwegian schools.

    Directory of Open Access Journals (Sweden)

    Berit Bungum

    2014-04-01

    Full Text Available Technology and design is seen by many as having a potential for students to work with science and mathematics in practical contexts. The view is particularly evident in the Norwegian curriculum, where technology and design is defined as an interdisciplinary topic involving Science, Mathematics and Art & Crafts. This paper reports from a video study of the use of mathematics and science in student projects in technology and design. It was found that the projects contained little conceptual knowledge from mathematics and science even when their purpose was to do so. Through an inductive analysis informed by perspectives on technology and technological knowledge, we identify four issues that explain why this is the case: (i Problem solving by other means, (ii Focus on product quality, (iii Not the right type of knowledge, and (iv Concepts and procedures not necessary for the purpose. These issues are related to the nature of technology rather than to pedagogy, and the results suggest that technology and design as a domain of knowledge should be represented in the curriculum in its own right and not as an arena for learning science and mathematics. 

  3. DELIVERING HOLISTIC EDUCATION USING ENGINEERING CURRICULUM THROUGH PERSONALIZED LEARNING, PEDAGOGY, TECHNOLOGY AND SPACE

    OpenAIRE

    C. P. YUNG; D. T. K. TIEN; ABDULKAREEM SH. MAHDI AL-OBAIDI

    2016-01-01

    The term “holistic education” can be defined in many different ways. In this study, holistic education is defined as learning that encompasses the cognitive, affective and psychomotor learning domains. Personalized learning is envisioned as an approach to help the students’ learn more effectively through tailoring the delivery to students’ preferred learning style. In addition, technology and learning space also play a very crucial role in student learning. “Can holistic education be deliv...

  4. Applications in Cross-Curriculum Teaching The Synthesis of the Design Studio and Building Technology Seminar

    OpenAIRE

    John Enright

    2012-01-01

    “Change or perish. You need to prepare yourself for a profession that you are notgoing to recognize a decade from now.”Thom Mayne, Remarks on building information modeling at the 2005 AIAConvention, Las Vegas, NVToday architects are faced with new challenges involving Integrated Project Delivery and associated digital technologies that are rapidly changing the way architects work. Collaboration is the key to this newway of working as architects discover that the management of buildinginformat...

  5. Mast cell proteases as pharmacological targets.

    Science.gov (United States)

    Caughey, George H

    2016-05-05

    Mast cells are rich in proteases, which are the major proteins of intracellular granules and are released with histamine and heparin by activated cells. Most of these proteases are active in the granule as well as outside of the mast cell when secreted, and can cleave targets near degranulating mast cells and in adjoining tissue compartments. Some proteases released from mast cells reach the bloodstream and may have far-reaching actions. In terms of relative amounts, the major mast cell proteases include the tryptases, chymases, cathepsin G, carboxypeptidase A3, dipeptidylpeptidase I/cathepsin C, and cathepsins L and S. Some mast cells also produce granzyme B, plasminogen activators, and matrix metalloproteinases. Tryptases and chymases are almost entirely mast cell-specific, whereas other proteases, such as cathepsins G, C, and L are expressed by a variety of inflammatory cells. Carboxypeptidase A3 expression is a property shared by basophils and mast cells. Other proteases, such as mastins, are largely basophil-specific, although human basophils are protease-deficient compared with their murine counterparts. The major classes of mast cell proteases have been targeted for development of therapeutic inhibitors. Also, a human β-tryptase has been proposed as a potential drug itself, to inactivate of snake venins. Diseases linked to mast cell proteases include allergic diseases, such as asthma, eczema, and anaphylaxis, but also include non-allergic diseases such as inflammatory bowel disease, autoimmune arthritis, atherosclerosis, aortic aneurysms, hypertension, myocardial infarction, heart failure, pulmonary hypertension and scarring diseases of lungs and other organs. In some cases, studies performed in mouse models suggest protective or homeostatic roles for specific proteases (or groups of proteases) in infections by bacteria, worms and other parasites, and even in allergic inflammation. At the same time, a clearer picture has emerged of differences in the

  6. Mast cell leukemia: an extremely rare disease.

    Science.gov (United States)

    Lu, Dai-Yin; Gau, Jyh-Pyng; Hong, Ying-Chung; Liu, Chun-Yu; Yu, Yuan-Bin; Hsiao, Liang-Tsai; Liu, Jin-Hwang; Chen, Po-Min; Chiou, Tzeon-Jye; Tzeng, Cheng-Hwai

    2014-08-01

    Systemic mastocytosis is characterized by pathologic proliferation and accumulation of mast cells in at least one extracutaneous organ such as liver, spleen, bone marrow, or lymph nodes. The clinical features are highly variable depending on impairment of the involved organ systems. It often raises diagnostic challenges. Here we report a case of a 78-year-old patient with mast cell leukemia. The literature is reviewed regarding the diagnosis and updated management of this rare disease.

  7. Mast Cell-Mediated Mechanisms of Nociception

    OpenAIRE

    Anupam Aich; Afrin, Lawrence B.; Kalpna Gupta

    2015-01-01

    Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic responses has been of increasing interest, and mast cells have been proposed as key players in orchestrating inflammation-associated pain pathobiology due to their proximity to both vasculature and nerve...

  8. Incorporating Health Information Technology and Pharmacy Informatics in a Pharmacy Professional Didactic Curriculum -with a Team-based Learning Approach.

    Science.gov (United States)

    Hincapie, Ana L; Cutler, Timothy W; Fingado, Amanda R

    2016-08-25

    Objective. To incorporate a pharmacy informatics program in the didactic curriculum of a team-based learning institution and to assess students' knowledge of and confidence with health informatics during the course. Design. A previously developed online pharmacy informatics course was adapted and implemented into a team-based learning (TBL) 3-credit-hour drug information course for doctor of pharmacy (PharmD) students in their second didactic year. During a period of five weeks (15 contact hours), students used the online pharmacy informatics modules as part of their readiness assurance process. Additional material was developed to comply with the TBL principles. Online pre/postsurveys were administered to evaluate knowledge gained and students' perceptions of the informatics program. Assessment. Eighty-three second-year students (84% response rate) completed the surveys. Participants' knowledge of electronic health records, computerized physician order entry, pharmacy information systems, and clinical decision support was significantly improved. Additionally, their confidence significantly improved in terms of describing health informatics terminology, describing the benefits and barriers of using health information technology, and understanding reasons for systematically processing health information. Conclusion. Students responded favorably to the incorporation of pharmacy informatics content into a drug information course using a TBL approach. Students met the learning objectives of seven thematic areas and had positive attitudes toward the course after its completion.

  9. Development of Curriculum for ""Information"" Teacher Training Based upon Information Science and Technology Education : Comparative Study on Existent Teacher Training Curricula

    OpenAIRE

    山本, 透; 上田, 邦夫

    2003-01-01

    The rapid progress of advanced information technology is going to change the situation and environment which surround information education. A new government-guidelines-for-teaching for high schools was notified on March 29, 1999, and a subject of information was newly established. Furthermore, the contents of the curriculum in connection with the subject of information license were clarified in July, 2000. While it has been indefinite what subject course is needed from a viewpoint of ""infor...

  10. Architectural and Building Construction Technology; A Suggested 2-Year Post High School Curriculum. Technical Education Program Series No. 9.

    Science.gov (United States)

    Office of Education (DHEW), Washington, DC.

    This curriculum guide is for administrators and their advisors to use in meeting local, state, and regional needs in training architectual and building construction technicians at the post-high school level. It was developed by a technical education specialist at the national level. The guide provides: (1) a suggested curriculum plan, (2) course…

  11. Developing Technology-Mediated Entries into Hidden Mathematics Curriculum as a Vehicle for "Good Learning" by Elementary Pre-Teachers

    Science.gov (United States)

    Abramovich, Sergei; Brouwer, Peter

    2004-01-01

    This paper suggests that knowledge of the school mathematics curriculum, as one of the key components of teachers' education, can be extended to include concepts and structures that generally belong to hidden domains of the curriculum. Motivated by work done with elementary pre-service teachers in a mathematics course employing a hidden…

  12. Curriculum Reform Research of Computer Network Technology Based on School-Enterprise Cooperation

    Science.gov (United States)

    Liu, Peng

    There is growing concern about falling levels of student engagement with school science, as evidenced by studies of student attitudes, and decreasing participation at the post compulsory level. College-enterprise cooperation model is a new model of cultivating application-typed talents in college by cooperating with enterprises. In the paper, we analyze the teaching problems in the course of "Computer Network Technology", propose guidelines with teaching practice. Then we explored the reform ways to enhance students' self-learning ability. Finally, the conclusion is given.

  13. Overview of physics results from MAST towards ITER/DEMO and the MAST Upgrade

    DEFF Research Database (Denmark)

    Meyer, H.; Abel, I.G.; Akers, R.J.

    2013-01-01

    New diagnostic, modelling and plant capability on the Mega Ampère Spherical Tokamak (MAST) have delivered important results in key areas for ITER/DEMO and the upcoming MAST Upgrade, a step towards future ST devices on the path to fusion currently under procurement. Micro-stability analysis of the...

  14. Overview of physics results from MAST towards ITER/DEMO and the MAST Upgrade

    NARCIS (Netherlands)

    Meyer, H.; Abel, I. G.; Akers, R. J.; Allan, A.; Allan, S. Y.; Appel, L. C.; Asunta, O.; Barnes, M.; Barratt, N. C.; N. Ben Ayed,; Bradley, J. W.; Canik, J.; Cahyna, P.; Cecconello, M.; Challis, C. D.; Chapman, I.T.; Ciric, D.; Colyer, G.; Conway, N. J.; Cox, M.; Crowley, B. J.; Cowley, S. C.; Cunningham, G.; Danilov, A.; Darke, A.; de Bock, M. F. M.; De Temmerman, G.; Dendy, R. O.; Denner, P.; Dickinson, D.; Dnestrovskij, A. Y.; Dnestrovsky, Y.; Driscoll, M. D.; Dudson, B.; Dunai, D.; Dunstan, M.; Dura, P.; Elmore, S.; Field, A. R.; Fishpool, G.; Freethy, S.; Fundamenski, W.; Garzotti, L.; Ghim, Y. C.; Gibson, K. J.; Gryaznevich, M. P.; Harrison, J.; E. Havlíčková,; Hawkes, N. C.; Heidbrink, W. W.; Hender, T. C.; Highcock, E.; Higgins, D.; Hill, P.; Hnat, B.; Hole, M. J.; J. Horáček,; Howell, D. F.; Imada, K.; Jones, O.; Kaveeva, E.; Keeling, D.; Kirk, A.; M. Kočan,; Lake, R. J.; Lehnen, M.; Leggate, H. J.; Liang, Y.; Lilley, M. K.; Lisgo, S. W.; Liu, Y. Q.; Lloyd, B.; Maddison, G. P.; Mailloux, J.; Martin, R.; McArdle, G. J.; McClements, K. G.; McMillan, B.; Michael, C.; Militello, F.; Molchanov, P.; Mordijck, S.; Morgan, T.; Morris, A. W.; Muir, D. G.; Nardon, E.; Naulin, V.; Naylor, G.; Nielsen, A. H.; O' Brien, M. R.; O' Gorman, T.; Pamela, S.; Parra, F. I.; Patel, A.; Pinches, S. D.; Price, M. N.; Roach, C. M.; Robinson, J. R.; Romanelli, M.; Rozhansky, V.; Saarelma, S.; Sangaroon, S.; Saveliev, A.; Scannell, R.; Seidl, J.; Sharapov, S. E.; Schekochihin, A. A.; Shevchenko, V.; Shibaev, S.; Stork, D.; Storrs, J.; Sykes, A.; Tallents, G. J.; Tamain, P.; Taylor, D.; Temple, D.; Thomas-Davies, N.; Thornton, A.; Turnyanskiy, M. R.; M. Valovič,; Vann, R. G. L.; Verwichte, E.; Voskoboynikov, P.; Voss, G.; Warder, S. E. V.; Wilson, H. R.; Wodniak, I.; Zoletnik, S.; Zagorski, R.; MAST Team,; NBI Team,

    2013-01-01

    New diagnostic, modelling and plant capability on the Mega Ampère Spherical Tokamak (MAST) have delivered important results in key areas for ITER/DEMO and the upcoming MAST Upgrade, a step towards future ST devices on the path to fusion currently under procurement. Micro-stability analysis of the pe

  15. THE INTEGRATION OF INFORMATION AND COMMUNICATION TECHNOLOGY (ICT INTO PRIMARY SCHOOLS CURRICULUM

    Directory of Open Access Journals (Sweden)

    Olaniyi Alaba Sofowora

    2012-06-01

    Full Text Available This study is a critical overview of the efforts of the Nigerian government at integrating Information and Communication Technology (ICT into education. It also assessed the availability of these facilities and infrastructure as stated in the strategic ICT objectives. The study in addition investigated whether the sample used have the skills needed for ICT utilization and factors/challenges that affects the diffusion of ICT in education. This is with the ultimate view of providing empirical information on the extent of achieving the vision and objectives of the National policy for ICT in Nigeria. The study employed exploratory research design. Three hundred participants constituted the sample for this study. The sample was selected from ten schools using simple random sampling technique. While the schools were selected using stratified sampling technique, based on the Local Education Authority Area, school type and location. The research instrument is made up of a self-designed questionnaire on five point Likert Scale. They were derived from relevant literature and the research objectives and were validated by exerts from the Departments of Educational Technology, Educational Foundations and Counseling and ICT teachers in public schools in Ife for content validity. The reliability of the instrument was also determined using Pearson Moment Correlation. A correlation of 0.87 was found. The data was analyzed using One way analysis of Variance (ANOVA .The findings showed that ICT facilities are not universally available. It was also found that 10 years after the enactment of the Nigerian National ICT Policy, internet services are yet to be fully made available in all the government Institutions in Nigeria

  16. 计算机多媒体技术专业课程体系的构建%The Construction of Curriculum System of Digital Media Technology

    Institute of Scientific and Technical Information of China (English)

    马绍惠; 谌湘倩; 魏勇; 孙新领; 李扬波; 徐立新

    2015-01-01

    According to the digital media technology industry needs and the training objectives of digital media technology major ,the three lines crossing and spiral ascending curriculum system w as con‐structed .This curriculum system has three aspects contents about webpage design ,3D animation and the film and televisionpostproduction ,and the three aspects contents have the characters of technology convergence ,intercross and complementing .This curriculum system achieved the ascending from profes‐sional content objective to ability objective and form job objective to occupation objective .In sum ,the curriculum system has clear training objectives that combine both general character and individual char‐acter of students .%依据计算机多媒体技术行业的需求及计算机多媒体技术专业的培养目标,设置了“三线交叉螺旋递升”的计算机多媒体技术专业课程体系。在该课程体系中,网页设计、三维动画和影视后期制作三条培养主线的课程技术交融,相互交叉,相辅相成,实现了从专业内容目标向能力目标、工作目标到职业目标的递升。该课程体系专业方向明确,兼顾人才培养的共性和个性。

  17. Methods and Tools to Align Curriculum to the Skills and Competencies Needed by the Workforce - an Example from Geospatial Science and Technology

    Science.gov (United States)

    Johnson, A. B.

    2012-12-01

    Geospatial science and technology (GST) including geographic information systems, remote sensing, global positioning systems and mobile applications, are valuable tools for geoscientists and students learning to become geoscientists. GST allows the user to analyze data spatially and temporarily and then visualize the data and outcomes in multiple formats (digital, web and paper). GST has evolved rapidly and it has been difficult to create effective curriculum as few guidelines existed to help educators. In 2010, the US Department of Labor (DoL), in collaboration with the National Geospatial Center of Excellence (GeoTech Center), a National Science Foundation supported grant, approved the Geospatial Technology Competency Mode (GTCM). The GTCM was developed and vetted with industry experts and provided the structure and example competencies needed across the industry. While the GTCM was helpful, a more detailed list of skills and competencies needed to be identified in order to build appropriate curriculum. The GeoTech Center carried out multiple DACUM events to identify the skills and competencies needed by entry-level workers. DACUM (Developing a Curriculum) is a job analysis process whereby expert workers are convened to describe what they do for a specific occupation. The outcomes from multiple DACUMs were combined into a MetaDACUM and reviewed by hundreds of GST professionals. This provided a list of more than 320 skills and competencies needed by the workforce. The GeoTech Center then held multiple workshops across the U.S. where more than 100 educators knowledgeable in teaching GST parsed the list into Model Courses and a Model Certificate Program. During this process, tools were developed that helped educators define which competency should be included in a specific course and the depth of instruction for that competency. This presentation will provide details about the process, methodology and tools used to create the Models and suggest how they can be used

  18. 3D CAD Technology Curriculum Design and Reform%3D CAD技术的课程设计教改探讨

    Institute of Scientific and Technical Information of China (English)

    杨艳

    2011-01-01

    As engineering design and product development tools of 3D CAD technology is bound to spread.The development of 3D CAD technology, university teaching also poses a severe challenge,3D CAD technology, curriculum design is an important part of teaching,should be fully integrated with the traditional two-dimensional engineering drawings and CAD,three-dimensional CAD teaching,to carry out 3D CAD technology, curriculum design the use of computer technology to enhance teaching three-dimensional product modeling capabilities.%作为工程设计和产品开发工具的3D CAD技术必将普及。3DCAD技术的发展对高校教学也提出了严峻的挑战,3DCAD技术的课程设计教学是一个重要环节,应充分结合传统工程制图与二维CAD、三维CAD的教学,开展3D CAD技术的课程设计教学以提高运用计算机技术建立三维产品模型的能力。

  19. 《模具逆向工程技术》课程建设%The Curriculum Construction of Mold Reverse Engineering Technology

    Institute of Scientific and Technical Information of China (English)

    潘洋宇

    2011-01-01

    In this paper,the meanings and goals of mold reverse engineering technology are introduced.Combined the require-ments of the higher vocational education curriculum reform,the thinking of curriculum design of mold Reverse engineering tech-nology is analyzed in detail.The curriculum content design takes account of knowledge and practical operation,by means of pro-ject education to enhance teaching efficiency.%本文介绍了《模具逆向工程技术》课程的意义和目标。结合现代高等职业教育教学改革要求,详细叙述了《模具逆向工程技术》课程设计理念。课程内容设计兼顾理论知识和实践操作,通过项目化教学提高教学效果。

  20. Do mast cells link obesity and asthma?

    Science.gov (United States)

    Sismanopoulos, N; Delivanis, D-A; Mavrommati, D; Hatziagelaki, E; Conti, P; Theoharides, T C

    2013-01-01

    Asthma is a chronic inflammatory disease of the lungs. Both the number of cases and severity of asthma have been increasing without a clear explanation. Recent evidence suggests that obesity, which has also been increasing alarmingly, may worsen or precipitate asthma, but there is little evidence of how obesity may contribute to lung inflammation. We propose that mast cells are involved in both asthma and obesity by being the target and source of adipocytokines, 'alarmins' such as interleukin-9 (IL-9) and interleukin-33 (IL-33), and stress molecules including corticotropin-releasing hormone (CRH) and neurotensin (NT), secreted in response to the metabolic burden. In particular, CRH and NT have synergistic effects on mast cell secretion of vascular endothelial growth factor (VEGF). IL-33 augments VEGF release induced by substance P (SP) and tumor necrosis factor (TNF) release induced by NT. Both IL-9 and IL-33 also promote lung mast cell infiltration and augment allergic inflammation. These molecules are also expressed in human mast cells leading to autocrine effects. Obese patients are also less sensitive to glucocorticoids and bronchodilators. Development of effective mast cell inhibitors may be a novel approach for the management of both asthma and obesity. Certain flavonoid combinations may be a promising new treatment approach.

  1. Nerve growth factor interactions with mast cells.

    Science.gov (United States)

    Kritas, S K; Caraffa, A; Antinolfi, P; Saggini, A; Pantalone, A; Rosati, M; Tei, M; Speziali, A; Saggini, R; Pandolfi, F; Cerulli, G; Conti, P

    2014-01-01

    Neuropeptides are involved in neurogenic inflammation where there is vasodilation and plasma protein extravasion in response to this stimulus. Nerve growth factor (NGF), identified by Rita Levi Montalcini, is a neurotrophin family compound which is important for survival of nociceptive neurons during their development. Therefore, NGF is an important neuropeptide which mediates the development and functions of the central and peripheral nervous system. It also exerts its proinflammatory action, not only on mast cells but also in B and T cells, neutrophils and eosinophils. Human mast cells can be activated by neuropeptides to release potent mediators of inflammation, and they are found throughout the body, especially near blood vessels, epithelial tissue and nerves. Mast cells generate and release NGF after degranulation and they are involved in iperalgesia, neuroimmune interactions and tissue inflammation. NGF is also a potent degranulation factor for mast cells in vitro and in vivo, promoting differentiation and maturation of these cells and their precursor, acting as a co-factor with interleukin-3. In conclusion, these studies are focused on cross-talk between neuropeptide NGF and inflammatory mast cells.

  2. The Challenge of an Integrated Curriculum: Avoid the Isolated Road.

    Science.gov (United States)

    Boyer, Mark R.

    1993-01-01

    Curriculum integration is a systemic phenomenon that traverses both traditional and nontraditional territories. Scottsdale (Arizona) Public Schools' strategic plan includes curriculum integration elements in seven categories--community relations, curriculum and instruction, funding, human resources, management, communication, and technology. The…

  3. Mast cell density in cardio-esophageal mucosa.

    Science.gov (United States)

    Mahjoub, Fatemeh E; Asefi, Hoda; Farahmand, Fatemeh; Pourpak, Zahra; Amini, Zahra

    2014-12-01

    Mast cells are related to certain gastrointestinal complaints. Mast cell density has not been studied in cardio-esophageal region to the best of our knowledge. In this study we wanted to obtain an estimate of mast cell density in this region and compare it with mast cell density in antrum. From April 2007 till March 2010, we chose children (mast cell density in the cardiac mucosa was 33.41 ± 32.75 in 0.25 mm2 (range: 0-155), which was two times of that in antral mucosa. We found a significant but weak positive correlation at the 0.05 level between mast cell density of cardiac mucosa and the antrum. Higher mast cell counts were seen in cardiac mucosa in this study. Significant positive correlation between mast cell density of cardiac mucosa and the antrum could hint to a single underlying etiology for the inflammatory process in gastro- esophageal junction and gastric mucosa.

  4. The emerging role of mast cells in liver disease.

    Science.gov (United States)

    Jarido, Veronica; Kennedy, Lindsey; Hargrove, Laura; Demieville, Jennifer; Thomson, Joanne; Stephenson, Kristen; Francis, Heather

    2017-08-01

    The depth of our knowledge regarding mast cells has widened exponentially in the last 20 years. Once thought to be only important for allergy-mediated events, mast cells are now recognized to be important regulators of a number of pathological processes. The revelation that mast cells can influence organs, tissues, and cells has increased interest in mast cell research during liver disease. The purpose of this review is to refresh the reader's knowledge of the development, type, and location of mast cells and to review recent work that demonstrates the role of hepatic mast cells during diseased states. This review focuses primarily on liver diseases and mast cells during autoimmune disease, hepatitis, fatty liver disease, liver cancer, and aging in the liver. Overall, these studies demonstrate the potential role of mast cells in disease progression.

  5. Quantification and Localization of Mast Cells in Periapical Lesions

    African Journals Online (AJOL)

    of the potential range of mast cell function and interactions in ... possible role played by mast cells in the periapical granuloma and radicular cyst. Hence, this study is to ... and processed by Statistical Package for Social Sciences,. Windows 7 ...

  6. Curriculum Animation

    Science.gov (United States)

    Gose, Michael D.

    2004-01-01

    Twenty-five teachers with reputations for artistry in curriculum planning were interviewed about their "curriculum animation" plans or how they ensured their curriculum was brought to life. Their statements indicated that much of their planning is informal and intuitive, and that the criteria they use for their curriculum includes: (1) it is…

  7. Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    Inmaculada; Lopez-Font; Sabrina; Gea-Sorlí; Enrique; de-Madaria; Luis; M; Gutiérrez; Miguel; Pérez-Mateo; Daniel; Closa

    2010-01-01

    AIM:To study the activation of pancreatic and pulmonary mast cells and the effect of mast cell inhibition on the activation of peritoneal and alveolar macrophages during acute pancreatitis.METHODS:Pancreatitis was induced by intraductal infusion of 5% sodium taurodeoxycholate in rats.The mast cell inhibitor cromolyn was administered intraperitoneally(i.p.) 30 min before pancreatitis induction.The pancreatic and pulmonary tissue damage was evaluated histologically and mast cells and their state of activation...

  8. Mast Cell-Mediated Mechanisms of Nociception.

    Science.gov (United States)

    Aich, Anupam; Afrin, Lawrence B; Gupta, Kalpna

    2015-12-04

    Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic responses has been of increasing interest, and mast cells have been proposed as key players in orchestrating inflammation-associated pain pathobiology due to their proximity to both vasculature and nerve fibers. Molecular underpinnings of mast cell-mediated pain can be disease-specific. Understanding such mechanisms is critical for developing disease-specific targeted therapeutics to improve analgesic outcomes. We review molecular mechanisms that may contribute to nociception in a disease-specific manner.

  9. Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression

    NARCIS (Netherlands)

    Wezel, Anouk; Lagraauw, H Maxime; van der Velden, Daniël; de Jager, Saskia C A; Quax, Paul H A; Kuiper, Johan; Bot, Ilze

    2015-01-01

    AIMS: Activated mast cells have been identified in the intima and perivascular tissue of human atherosclerotic plaques. As mast cells have been described to release a number of chemokines that mediate leukocyte fluxes, we propose that activated mast cells may play a pivotal role in leukocyte recruit

  10. Pavlovian Conditioning of Rat Mucosal Mast Cells to Secrete Rat Mast Cell Protease II

    Science.gov (United States)

    MacQueen, Glenda; Marshall, Jean; Perdue, Mary; Siegel, Shepard; Bienenstock, John

    1989-01-01

    Antigen (egg albumin) injections, which stimulate mucosal mast cells to secrete mediators, were paired with an audiovisual cue. After reexposure to the audiovisual cue, a mediator (rat mast cell protease II) was measured with a sensitive and specific assay. Animals reexposed to only the audiovisual cue released a quantity of protease not significantly different from animals reexposed to both the cue and the antigen; these groups released significantly more protease than animals that had received the cue and antigen in a noncontingent manner. The results support a role for the central nervous system as a functional effector of mast cell function in the allergic state.

  11. Extendable retractable telescopic mast for deployable structures

    Science.gov (United States)

    Schmid, M.; Aguirre, M.

    1986-01-01

    The Extendable and Retractable Mast (ERM) which is presently developed by Dornier in the frame of an ESA-contract, will be used to deploy and retract large foldable structures. The design is based on a telescopic carbon-fiber structure with high stiffness, strength and pointing accuracy. To verify the chosen design, a breadboard model of an ERM was built and tested under thermal vacuum (TV)-conditions. It is planned as a follow-on development to manufacture and test an Engineering Model Mast. The Engineering Model will be used to establish the basis for an ERM-family covering a wide range of requirements.

  12. Dear Minister, This Is Why Design and Technology Is a Very Important Subject in the School Curriculum: John Eggleston Memorial Lecture, Delivered at the Design & Technology Association Education and International Research Conference, Designing a Better Future, Friday 8th July 2011 at Keele University

    Science.gov (United States)

    Barlex, David

    2011-01-01

    The paper is in four parts. Part 1 considers the justification for including design and technology in the school curriculum. Part 2 suggests the content for the subject at Key Stage 3. Part 3 describes some of the ways the subject might be taught. Part 4 considers ways in which the curriculum can be devised so that it is irresistible and…

  13. Developing your own curriculum

    OpenAIRE

    Baldwin, N.; Barlex, D

    2007-01-01

    This chapter will explore the processes by which a newly qualified teacher can make a contribution to the design & technology curriculum. It is in six parts. First the chapter will consider the classroom conditions a teacher must create if his or her teaching is to be successful. Second we will explore four key features that determine the success of a subject in the curriculum. Third we will investigate how a newly qualified teacher might develop and articulate their vision for the subject. F...

  14. Mast Cell: A Multi-Functional Master Cell.

    Science.gov (United States)

    Krystel-Whittemore, Melissa; Dileepan, Kottarappat N; Wood, John G

    2015-01-01

    Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings. With respect to normal physiological functions, mast cells are known to regulate vasodilation, vascular homeostasis, innate and adaptive immune responses, angiogenesis, and venom detoxification. On the other hand, mast cells have also been implicated in the pathophysiology of many diseases, including allergy, asthma, anaphylaxis, gastrointestinal disorders, many types of malignancies, and cardiovascular diseases. This review summarizes the current understanding of the role of mast cells in many pathophysiological conditions.

  15. Snow snakes and science agency: Empowering American Indian students through a culturally-based science, technology, engineering, and mathematics (STEM) curriculum

    Science.gov (United States)

    Miller, Brant Gregory

    Mainstream curricula have struggled to provide American Indian students with meaningful learning experiences. This research project studied a novel approach to engaging students with science, technology, engineering, and mathematics (STEM) content through a culturally-based context. The traditional American Indian game of Snow Snakes (shushumeg in Ojibwe) presented a highly engaging context for delivering STEM content. Through the engaging context of snow snakes, the designed STEM curriculum explicitly applied mathematics (scaling and data), and science (force and motion) to an engineering prototype iteration that used available materials and tools (technology) for success. It was hypothesized that by engaging students through the carefully integrated STEM curriculum, driven by the culturally based context of snow snakes, students would exhibit an increase in science agency and achievement. The overarching research question explored for this study was: How does a culturally-based and integrated STEM curriculum impact student's science agency? Associated sub-questions were: (1) What does science agency look like for 6th grade students? (2) What key experiences are involved in the development of science agency through a culturally-based STEM curriculum context? And (3) What are the impacts on the community associated with the implementation of a culturally-based STEM curriculum? A case study research design was implemented for this research. Yin (2003) defines a case study as investigating a phenomenon (e.g. science agency) which occurs within authentic contexts (e.g. snow snakes, Adventure Learning, and Eagle Soaring School) especially when the boundaries between phenomenon and context are unclear. For this case study Eagle Soaring School acted as the bounded case with students from the 6th grade class representing the embedded units. Science agency was the theoretical framework for data analysis. Major findings were categorized as science and STEM learning, agency

  16. 30 CFR 57.7004 - Drill mast.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Drill mast. 57.7004 Section 57.7004 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Drilling and Rotary Jet...

  17. 30 CFR 56.7004 - Drill mast.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Drill mast. 56.7004 Section 56.7004 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Drilling and Rotary Jet...

  18. Vibrational Based Inspection Of A Steel Mast

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Rytter, A.

    1994-01-01

    The aim of this paper is to present the results from a research project concerning vibrational based inspection of a 20 meter high steel mast containing well defined damages. Introductory analyses dealing with among other things evaluation of potential damage indicators and determination...

  19. iMAST FY2007 Annual Report

    Science.gov (United States)

    2007-01-01

    Laser fabrication , in the form of laser cutting and laser beam welding, offers tremendous opportunity for reducing cost of highly-engineered...laser stir welding process during fabrication and the finished panel is shown here. Laser Fabrication of Advanced Structures 22 iMAST FY2006 Annual

  20. Overview of physics results from MAST

    NARCIS (Netherlands)

    Lloyd, B.; Akers, R. J.; Alladio, F.; Allan, S.; Appel, L. C.; Barnes, M.; Barratt, N. C.; N. Ben Ayed,; Breizman, B. N.; Cecconello, M.; Challis, C. D.; Chapman, I.T.; Ciric, D.; Colyer, G.; Connor, J. W.; Conway, N. J.; Cox, M.; Cowley, S. C.; Cunningham, G.; Darke, A.; De Bock, M.; Delchambre, E.; De Temmerman, G.; Dendy, R. O.; Denner, P.; Driscoll, M. D.; Dudson, B.; Dunai, D.; Dunstan, M.; Elmore, S.; Field, A. R.; Fishpool, G.; Freethy, S.; Garzotti, L.; Gibson, K. J.; Gryaznevich, M. P.; Guttenfelder, W.; Harrison, J.; Hastie, R. J.; Hawkes, N. C.; Hender, T. C.; Hnat, B.; Howell, D. F.; Hua, M. D.; Hubbard, A.; Huysmans, G.; Keeling, D.; Kim, Y. C.; Kirk, A.; Liang, Y.; Lilley, M. K.; Lisak, M.; Lisgo, S.; Liu, Y. Q.; Maddison, G. P.; Maingi, R.; Manhood, S. J.; Martin, R.; McArdle, G. J.; McCone, J.; Meyer, H.; Michael, C.; Mordijck, S.; Morgan, T.; Morris, A. W.; Muir, D. G.; Nardon, E.; Naylor, G.; O' Brien, M. R.; O' Gorman, T.; Palenik, J.; Patel, A.; Pinches, S. D.; Price, M. N.; Roach, C. M.; Rozhansky, V.; Saarelma, S.; Sabbagh, S. A.; Saveliev, A.; Scannell, R.; Sharapov, S. E.; Shevchenko, V.; Shibaev, S.; Stork, D.; Storrs, J.; Suttrop, W.; Sykes, A.; Tamain, P.; Taylor, D.; Temple, D.; Thomas-Davies, N.; Thornton, A.; Turnyanskiy, M. R.; Valovic, M.; Vann, R. G. L.; Voss, G.; Walsh, M. J.; Warder, S. E. V.; Wilson, H. R.; Windridge, M.; Wisse, M.; Zoletnik, S.

    2011-01-01

    Major developments on the Mega Amp Spherical Tokamak (MAST) have enabled important advances in support of ITER and the physics basis of a spherical tokamak (ST) based component test facility (CTF), as well as providing new insight into underlying tokamak physics. For example, L-H transition studies

  1. Overview of recent physics results from MAST

    DEFF Research Database (Denmark)

    Kirk, A.; Adamek, J.; Akers, R.J.

    2017-01-01

    New results from MAST are presented that focus on validating models in order to extrapolate to future devices. Measurements during start-up experiments have shown how the bulk ion temperature rise scales with the square of the reconnecting field. During the current ramp-up, models are not able to...

  2. Mast cell progenitors: origin, development and migration to tissues.

    Science.gov (United States)

    Dahlin, Joakim S; Hallgren, Jenny

    2015-01-01

    Mast cells in tissues are developed from mast cell progenitors emerging from the bone marrow in a process highly regulated by transcription factors. Through the advancement of the multicolor flow cytometry technique, the mast cell progenitor population in the mouse has been characterized in terms of surface markers. However, only cell populations with enriched mast cell capability have been described in human. In naïve mice, the peripheral tissues have a constitutive pool of mast cell progenitors. Upon infections in the gut and in allergic inflammation in the lung, the local mast cell progenitor numbers increase tremendously. This review focuses on the origin and development of mast cell progenitors. Furthermore, the evidences for cells and molecules that govern the migration of these cells in mice in vivo are described.

  3. Mechanisms of glyceryl trinitrate provoked mast cell degranulation

    DEFF Research Database (Denmark)

    Pedersen, Sara Hougaard; Ramachandran, Roshni; Amrutkar, Dipak Vasantrao;

    2015-01-01

    inflammation and dural mast cell degranulation is supported by the effectiveness of prednisolone on glyceryl trinitrate-induced delayed headache. METHODS: Using a newly developed rat model mimicking the human glyceryl trinitrate headache model, we have investigated the occurrence of dural mast cell...... glyceryl trinitrate-induced mast cell degranulation whereas the calcitonin gene-related peptide-receptor antagonist olcegepant and the substance P receptor antagonist L-733,060 did not affect mast cell degranulation. However, topical application of two different nitric oxide donors did not cause mast cell...... degranulation ex vivo. CONCLUSIONS: Direct application of an exogenous nitric oxide donor on dural mast cells does not cause mast cell degranulation ex vivo. In vivo application of the nitric oxide donor glyceryl trinitrate leads to a prominent level of degranulation via a yet unknown mechanism. This effect can...

  4. P2 receptor-mediated signaling in mast cell biology.

    Science.gov (United States)

    Bulanova, Elena; Bulfone-Paus, Silvia

    2010-03-01

    Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and anti-tumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of mast cells to the extracellular ATP release and to the maintenance of extracellular nucleotides pool. Recent publications highlight the importance of purinergic signaling for the pathogenesis of chronic airway inflammation. Therefore, the role of ATP and P2 receptors in allergic inflammation with focus on mast cells was analyzed. Finally, ATP functions as mast cell autocrine/paracrine factor and as messenger in intercellular communication between mast cells, nerves, and glia in the central nervous system.

  5. Mast cell numbers in normal and glaucomatous canine eyes.

    Science.gov (United States)

    Louden, C; Render, J A; Carlton, W W

    1990-05-01

    Numbers of mast cells in the cornea, sclera, choroid, ciliary body, iris, and retina of sections of globes from 35 clinically normal dogs and 34 dogs with secondary glaucoma was determined. Fixed globes were trimmed along a vertical midsagittal plane and embedded in paraffin. Tissue sections, approximately 6 microns thick, were stained with toluidine blue for identification of mast cells. In normal globes, most of the mast cells were observed in the anterior portion of the uvea, and fewer mast cells were seen in the choroid and sclera. Mast cells were not observed in the retina and were seldom observed in the cornea of dogs with or without glaucoma. In sections of glaucomatous globes, mast cells were distributed evenly in the uvea and sclera, and fewer mast cells were present than in normal globes, regardless of the cause of glaucoma.

  6. Mast cell synapses and exosomes: membrane contacts for information exchange

    Directory of Open Access Journals (Sweden)

    Amanda eCarroll-Portillo

    2012-03-01

    Full Text Available In addition to their central role in allergy, mast cells are involved in a wide variety of cellular interactions during homeostasis and disease. In this review, we discuss the ability of mast cells to extend their mechanisms for intercellular communication beyond the release of soluble mediators. These include formation of mast cell synapses on antigen presenting surfaces, as well as cell-cell contacts with dendritic cells and T cells. Release of membrane-bound exosomes also provide for the transfer of antigen, mast cell proteins and RNA to other leukocytes. With the recognition of the extended role mast cells have during immune modulation, further investigation of the processes in which mast cells are involved is necessary. This reopens mast cell research to exciting possibilities, demonstrating it to be an immunological frontier.

  7. Collaborative Learning in the Scottish Curriculum for Excellence: The Challenges of Assessment and Potential of Multi-Touch Technology

    Science.gov (United States)

    McKechan, Sandra; Ellis, Jennifer

    2014-01-01

    Scottish educational policy advocates the benefits of collaborative learning as a way of developing critical life skills, across the primary curriculum. In this paper, the rationale for collaborative learning, and specifically the Critical Skills (CS) approach, is considered along with an account of the perspectives of primary teachers…

  8. Negotiating the Inclusion of Nanoscience Content and Technology in Science Curriculum: An Examination of Secondary Teachers' Thinking in a Professional Development Project

    Science.gov (United States)

    Wells, Jennifer Gayle

    The Next Generation Science Standards represent a significant challenge for K--12 school reform in the United States in the science, technology, engineering and mathematics (STEM) disciplines (NSTA, 2012). One important difference between the National Science Education Standards (NRC, 1996) and the Next Generation Science Standards (Achieve, 2013) is the more extensive inclusion of nanoscale science and technology. Teacher PD is a key vehicle for implementing this STEM education reform effort (NRC, 2012; Smith, 2001). The context of this dissertation study is Project Nanoscience and Nanotechnology Outreach (NANO), a secondary level professional development program for teachers that provides a summer workshop, academic year coaching and the opportunity for teacher participants to borrow a table-top Phenom scanning electron microscope and a research grade optical microscope for use in their classrooms. This designed-based descriptive case study examined the thinking of secondary teachers in the 2012 Project NANO cohort as they negotiated the inclusion of novel science concepts and technology into secondary science curriculum. Teachers in the Project NANO 2012 summer workshop developed a two-week, inquiry-based unit of instruction drawing upon one or more of nine big ideas in nanoscale science and technology as defined by Stevens, Sutherland, and Krajcik (2011). This research examined teacher participants' metastrategic thinking (Zohar, 2006) which they used to inform their pedagogical content knowledge (Shulman, 1987) by focusing on the content knowledge teachers chose to frame their lessons, their rationales for such choices as well as the teaching strategies that they chose to employ in their Project NANO unit of instruction. The study documents teachers various entry points on a learning progression as teachers negotiated the inclusion of nanoscale science and technology into the curriculum for the first time. Implications and recommendations for teacher

  9. Are mast cells instrumental for fibrotic diseases?

    Directory of Open Access Journals (Sweden)

    Catherine eOvered-Sayer

    2014-01-01

    Full Text Available Idiopathic pulmonary fibrosis (IPF is a fatal lung disorder of unknown etiology characterised by accumulation of lung fibroblasts and extracellular matrix deposition, ultimately leading to compromised tissue architecture and lung function capacity. IPF has a heterogeneous clinical course; however the median survival after diagnosis is only 3-5 years. The pharmaceutical and biotechnology industry has made many attempts to find effective treatments for IPF, but the disease has so far defied all attempts at therapeutic intervention. Clinical trial failures may arise for many reasons, including disease heterogeneity, lack of readily measurable clinical end points other than overall survival, and, perhaps most of all, a lack of understanding of the underlying molecular mechanisms of the progression of IPF.The precise link between inflammation and fibrosis remains unclear, but it appears that immune cells can promote fibrosis by releasing fibrogenic factors. So far, however, therapeutic approaches targeting macrophages, neutrophils, or lymphocytes have failed to alter disease pathogenesis. A new cell to garner research interest in fibrosis is the mast cell. Increased numbers of mast cells have long been known to be present in pulmonary fibrosis and clinically correlations between mast cells and fibrosis have been reported. More recent data suggests that mast cells may contribute to the fibrotic process by stimulating fibroblasts resident in the lung, thus driving the pathogenesis of the disease. In this review, we will discuss the mast cell and its physiological role in tissue repair and remodelling, as well as its pathological role in fibrotic diseases such as IPF, where the process of tissue repair and remodelling is thought to be dysregulated.

  10. Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood

    DEFF Research Database (Denmark)

    Rådinger, Madeleine; Jensen, Bettina M; Kuehn, Hye Sun;

    2010-01-01

    Antigen-mediated mast cell activation is a pivotal step in the initiation of allergic disorders including anaphylaxis and atopy. To date, studies aimed at investigating the mechanisms regulating these responses, and studies designed to identify potential ways to prevent them, have primarily been...... conducted in rodent mast cells. However, to understand how these responses pertain to human disease, and to investigate and develop novel therapies for the treatment of human mast cell-driven disease, human mast cell models may have greater relevance. Recently, a number of systems have been developed...... to allow investigators to readily obtain sufficient quantities of human mast cells to conduct these studies. These mast cells release the appropriate suite of inflammatory mediators in response to known mast cell activators including antigen. These systems have also been employed to examine the signaling...

  11. e Ciências Afins (MAST

    Directory of Open Access Journals (Sweden)

    Marcus Granato

    2007-01-01

    Full Text Available MAST is a science and technology museum located on the premises of and within the architectural complex belonging to the former National Observatory of Rio de Janeiro. Soon after the museum was created, the historical heritage existing there – which pertains to a significant period of the history of science in Brazil – was listed by the Brazilian National Heritage Institute (Iphan and the Rio de Janeiro State Cultural Heritage Institute (Inepac in 1986 and 1987, respectively. The listed heritage comprises 16 buildings as well as a collection of scientific instruments and other significant artifacts, including a collection of furniture. Following on from previous interventions on the instruments in the collection and the astronomy domes within the campus, the restoration and rehabilitation of significant parts of the listed heritage under MAST’s responsibility were made possible through a partnership with VITAE Foundation. The project was carried out by a multidisciplinary team and based on historical research into the meridian circle and its shelter over a period of three years. It was accompanied by an exhaustive photographic recording of each stage of the project, including a diagnosis of the instrument is upkeep and its restoration, the rehabilitation of the pavilion, and the replacement of the instrument to its original position, as well as a description of the museum to provide the visitors with information about the restoration work carried out. It should be noted that the restored instrument was at great risk of being lost, as it had been left disassembled since the 1960s, and the top part of the dome that sheltered it had been demolished in the 1980s, leaving just a vestibule and the base of the dome, part of which was in danger of collapsing. The rationale behind this intervention was not to put the instrument back in working order, but to allow it to be viewed and understood by the public within the museum space that was created

  12. Mast Cells Produce a Unique Chondroitin Sulfate Epitope.

    Science.gov (United States)

    Farrugia, Brooke L; Whitelock, John M; O'Grady, Robert; Caterson, Bruce; Lord, Megan S

    2016-02-01

    The granules of mast cells contain a myriad of mediators that are stored and protected by the sulfated glycosaminoglycan (GAG) chains that decorate proteoglycans. Whereas heparin is the GAG predominantly associated with mast cells, mast cell proteoglycans are also decorated with heparan sulfate and chondroitin sulfate (CS). This study investigated a unique CS structure produced by mast cells that was detected with the antibody clone 2B6 in the absence of chondroitinase ABC digestion. Mast cells in rodent tissue sections were characterized using toluidine blue, Leder stain and the presence of mast cell tryptase. The novel CS epitope was identified in rodent tissue sections and localized to cells that were morphologically similar to cells chemically identified as mast cells. The rodent mast cell-like line RBL-2H3 was also shown to express the novel CS epitope. This epitope co-localized with multiple CS proteoglycans in both rodent tissue and RBL-2H3 cultured cells. These findings suggest that the novel CS epitope that decorates mast cell proteoglycans may play a role in the way these chains are structured in mast cells.

  13. Practice and Innovation on Construction of Computer Network Technology Curriculum System in Higher Vocational Colleges%高职计算机网络技术专业课程体系建设的实践与创新

    Institute of Scientific and Technical Information of China (English)

    李亚方; 张学军

    2012-01-01

    本文探讨了高职院校专业课程体系构建的原则、方法和步骤,具体对计算机网络技术专业课程体系的构建进行了阐述,从专业定位、专业建设思路、课程群、岗位群、行业标准与认证、课程资源的开发等方面进行了案例分析。%This paper discusses principles,methods and procedures of curriculum system construction in higher vocational colleges.It also elaborates on the construction of computer network technology curriculum system in analysis of specialty orientation,specialty construction ideas,curriculum group,post group,industry standards and certification,curriculum resources development.

  14. 英语教师如何理解信息技术与课程整合%How to Understand the Integration of Information Technology and Curriculum for English Teachers

    Institute of Scientific and Technical Information of China (English)

    贾志强

    2011-01-01

    The integration of information technology and curriculum is gradually accepted, utilized and innovated by fronthne teachers. This paper expounds how to accomplish the integration of information technology and curriculum in English teaching.%信息技术与课程整合正在慢慢被我们一线教师所接受、所利用,并不断创新。本文论述了英语教学中如何做好信息技术与课程的整合。

  15. Migraine pain, meningeal inflammation, and mast cells.

    Science.gov (United States)

    Levy, Dan

    2009-06-01

    Migraine pain has been attributed to an episode of local sterile meningeal inflammation and the subsequent activation of trigeminal primary afferent nociceptive neurons that supply the intracranial meninges and their related large blood vessels. However, the origin of this inflammatory insult and the endogenous factors that contribute to the activation of meningeal nociceptors remain largely speculative. A particular class of inflammatory cells residing within the intracranial milieu, known as meningeal mast cells, was suggested to play a role in migraine pathophysiology more than five decades ago, but until recently the exact nature of their involvement remained largely unexplored. This review examines the evidence linking meningeal mast cells to migraine and highlights current experimental data implicating these immune cells as potent modulators of meningeal nociceptors' activity and the genesis of migraine pain.

  16. MAST Propellant and Delivery System Design Methods

    Science.gov (United States)

    Nadeem, Uzair; Mc Cleskey, Carey M.

    2015-01-01

    A Mars Aerospace Taxi (MAST) concept and propellant storage and delivery case study is undergoing investigation by NASA's Element Design and Architectural Impact (EDAI) design and analysis forum. The MAST lander concept envisions landing with its ascent propellant storage tanks empty and supplying these reusable Mars landers with propellant that is generated and transferred while on the Mars surface. The report provides an overview of the data derived from modeling between different methods of propellant line routing (or "lining") and differentiate the resulting design and operations complexity of fluid and gaseous paths based on a given set of fluid sources and destinations. The EDAI team desires a rough-order-magnitude algorithm for estimating the lining characteristics (i.e., the plumbing mass and complexity) associated different numbers of vehicle propellant sources and destinations. This paper explored the feasibility of preparing a mathematically sound algorithm for this purpose, and offers a method for the EDAI team to implement.

  17. The SNARE machinery in mast cell secretion

    Directory of Open Access Journals (Sweden)

    Axel eLorentz

    2012-06-01

    Full Text Available Mast cells are known as inflammatory cells which exert their functions in allergic and anaphylactic reactions by secretion of numerous inflammatory mediators. During an allergic response, the high-affinity IgE receptor, FcεRI, becomes cross-linked by receptor-bound IgE and antigen resulting in immediate release of pre-synthesized mediators – stored in granules – as well as in de novo synthesis of various mediators like cytokines and chemokines. Soluble N-ethylmaleimide-Sensitive Factor (NSF Attachment Protein (SNAP Receptors (SNARE proteins were found to play a central role in regulating membrane fusion events during exocytosis. In addition, several accessory regulators like Munc13, Munc18, Rab GTPases, SCAMPs, complexins or synaptotagmins were found to be involved in membrane fusion. In this review we summarize our current knowledge about the SNARE machinery and its mechanism of action in mast cell secretion.

  18. Generation of mast cells from mouse fetus: analysis of differentiation and functionality, and transcriptome profiling using next generation sequencer.

    Directory of Open Access Journals (Sweden)

    Nobuyuki Fukuishi

    Full Text Available While gene knockout technology can reveal the roles of proteins in cellular functions, including in mast cells, fetal death due to gene manipulation frequently interrupts experimental analysis. We generated mast cells from mouse fetal liver (FLMC, and compared the fundamental functions of FLMC with those of bone marrow-derived mouse mast cells (BMMC. Under electron microscopy, numerous small and electron-dense granules were observed in FLMC. In FLMC, the expression levels of a subunit of the FcεRI receptor and degranulation by IgE cross-linking were comparable with BMMC. By flow cytometry we observed surface expression of c-Kit prior to that of FcεRI on FLMC, although on BMMC the expression of c-Kit came after FcεRI. The surface expression levels of Sca-1 and c-Kit, a marker of putative mast cell precursors, were slightly different between bone marrow cells and fetal liver cells, suggesting that differentiation stage or cell type are not necessarily equivalent between both lineages. Moreover, this indicates that phenotypically similar mast cells may not have undergone an identical process of differentiation. By comprehensive analysis using the next generation sequencer, the same frequency of gene expression was observed for 98.6% of all transcripts in both cell types. These results indicate that FLMC could represent a new and useful tool for exploring mast cell differentiation, and may help to elucidate the roles of individual proteins in the function of mast cells where gene manipulation can induce embryonic lethality in the mid to late stages of pregnancy.

  19. The Exploration of Vocational Computer Multimedia Technology Curriculum Design Practice%高职计算机多媒体技术专业课程体系设计实践探索

    Institute of Scientific and Technical Information of China (English)

    黄岩

    2015-01-01

    Higher vocational education is directly related to the quality of professional training of computer multimedia technology curriculum system design. Strengthening curriculum design is to enhance the vocational computer multimedia technology professional talent training quality, adapt to the social demand is the inevitable requirement of. Is discussed in this paper vocational computer multimedia technology curriculum system design principles and objectives, analysis of the curriculum design process, and on the design of curriculum structure and safeguard measures are proposed.%课程体系设计直接关系到高职计算机多媒体技术专业人才培养质量。强化课程体系设计是提升高职计算机多媒体技术专业人才培养质量、适应社会用人需求的必然要求。文章探讨了高职计算机多媒体技术专业课程体系设计的原则和目标,分析了课程体系设计流程,并就课程结构设计和保障措施提出了建议。

  20. Mast Cells in Abdominal Aortic Aneurysms

    DEFF Research Database (Denmark)

    Shi, Guo-Ping; Lindholt, Jes Sanddal

    2013-01-01

    Mast cells (MCs) are proinflammatory cells that play important roles in allergic responses, tumor growth, obesity, diabetes, atherosclerosis, and abdominal aortic aneurysm (AAA). Although the presence and function of MCs in atherosclerotic lesions have been thoroughly studied in human specimens...... neighboring cells, degrade extracellular matrix proteins, process latent bioactive molecules, promote angiogenesis, recruit additional inflammatory cells, and stimulate vascular cell apoptosis. These activities associate closely with medial elastica breakdown, medial smooth-muscle cell loss and thinning...

  1. Overview of recent physics results from MAST

    OpenAIRE

    KIRK, A.; Adamek, J.; Akers, RJ; Allan, S; Appel, L; Lucini, F Arese; Barnes, M; T. Barrett; Ayed, N Ben; Boeglin, W.; Bradley, J; Browning, P.K.; Brunner, J.; Cahyna, P.; Carr, M.

    2016-01-01

    New results from MAST are presented that focus on validating models in order to extrapolate to future devices. Measurements during start-up experiments have shown how the bulk ion temperature rise scales with the square of the reconnecting field. During the current ramp up models are not able to correctly predict the current diffusion. Experiments have been performed looking at edge and core turbulence. At the edge detailed studies have revealed how filament characteristic are responsible for...

  2. Modelling and Measurements of MAST Neutron Emission

    OpenAIRE

    Klimek, Iwona

    2016-01-01

    Measurements of neutron emission from a fusion plasma can provide a wealth of information on the underlying temporal, spatial and energy distributions of reacting ions and how they are affected by a wide range of magneto-hydro-dynamic (MHD) instabilities. This thesis focuses on the interpretation of the experimental measurements recorded by neutron flux monitors with and without spectroscopic capabilities installed on the Mega Ampere Spherical Tokamak (MAST). In particular, the temporally and...

  3. Mississippi Curriculum Framework for Computer Information Systems Technology. Computer Information Systems Technology (Program CIP: 52.1201--Management Information Systems & Business Data). Computer Programming (Program CIP: 52.1201). Network Support (Program CIP: 52.1290--Computer Network Support Technology). Postsecondary Programs.

    Science.gov (United States)

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for two programs in the state's postsecondary-level computer information systems technology cluster: computer programming and network support. Presented in the introduction are program descriptions and suggested course…

  4. Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis

    DEFF Research Database (Denmark)

    Larsen, M.S.; Mortensen, S.; Nordling, J.;

    2008-01-01

    OBJECTIVES To evaluate a simple method for counting mast cells, thought to have a role in the pathophysiology of bladder pain syndrome (BPS, formerly interstitial cystitis, a syndrome of pelvic pain perceived to be related to the urinary bladder and accompanied by other urinary symptoms, e. g....... frequency and nocturia), as > 28 mast cells/mm(2) is defined as mastocytosis and correlated with clinical outcome. PATIENTS AND METHODS The current enzymatic staining method (naphtolesterase) on 10 mu m sections for quantifying mast cells is complicated. In the present study, 61 patients had detrusor...... sections between, respectively. Mast cells were counted according to a well-defined procedure. RESULTS The old and the new methods, on 10 and 3 mu m sections, showed a good correlation between mast cell counts. When using tryptase staining and 3 mu m sections, the mast cell number correlated well...

  5. Characterization of mast cell secretory granules and their cell biology.

    Science.gov (United States)

    Azouz, Nurit Pereg; Hammel, Ilan; Sagi-Eisenberg, Ronit

    2014-10-01

    Exocytosis and secretion of secretory granule (SG) contained inflammatory mediators is the primary mechanism by which mast cells exert their protective immune responses in host defense, as well as their pathological functions in allergic reactions and anaphylaxis. Despite their central role in mast cell function, the molecular mechanisms underlying the biogenesis and secretion of mast cell SGs remain largely unresolved. Early studies have established the lysosomal nature of the mast cell SGs and implicated SG homotypic fusion as an important step occurring during both their biogenesis and compound secretion. However, the molecular mechanisms that account for key features of this process largely remain to be defined. A novel high-resolution imaging based methodology allowed us to screen Rab GTPases for their phenotypic and functional impact and identify Rab networks that regulate mast cell secretion. This screen has identified Rab5 as a novel regulator of homotypic fusion of the mast cell SGs that thereby regulates their size and cargo composition.

  6. IgE and mast cells in allergic disease.

    Science.gov (United States)

    Galli, Stephen J; Tsai, Mindy

    2012-05-04

    Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to think of them in other contexts. However, a large body of evidence now suggests that both IgE and mast cells are also key drivers of the long-term pathophysiological changes and tissue remodeling associated with chronic allergic inflammation in asthma and other settings. Such potential roles include IgE-dependent regulation of mast-cell functions, actions of IgE that are largely independent of mast cells and roles of mast cells that do not directly involve IgE. In this review, we discuss findings supporting the conclusion that IgE and mast cells can have both interdependent and independent roles in the complex immune responses that manifest clinically as asthma and other allergic disorders.

  7. Non-IgE mediated mast cell activation.

    Science.gov (United States)

    Yu, Yingxin; Blokhuis, Bart R; Garssen, Johan; Redegeld, Frank A

    2016-05-05

    Mast cells are crucial effector cells in allergic reactions, where IgE is the best known mechanism to trigger their degranulation and release of a vast array of allergic mediators. However, IgE is not the only component to stimulate these cells to degranulate, while mast cell activation can also result in differential release of mediators. There is a plethora of stimuli, such as IgG, complement components, TLR ligands, neuropeptides, cytokines, chemokines and other inflammatory products, that can directly trigger mast cell degranulation, cause selective release of mediators, and stimulate proliferation, differentiation and/or migration. Moreover, some of these stimuli have a synergic effect on the IgE-mediated mast cell activation. Because of the ability to respond to a large repertoire of stimuli, mast cells may act as a versatile cell in various physiological and pathological conditions. In this review, we discuss current knowledge on non-IgE stimuli for (human) mast cells.

  8. Sclerosing mediastinitis and mast cell activation syndrome.

    Science.gov (United States)

    Afrin, Lawrence B

    2012-03-15

    Sclerosing mediastinitis (ScM) is a rare, potentially life-threatening disorder, idiopathic in roughly half the cases. Systemic symptoms not attributable to sclerosis often appear in idiopathic ScM. Mast cell activation disease (MCAD) is a potential cause of these symptoms and also can cause sclerosis. ScM has not previously been associated with MCAD. Presented here are the first two cases of ScM associated with MCAD, specifically mast cell activation syndrome (MCAS). CASE 1: A 58-year-old chronically polymorbid woman developed ScM following matched sibling allogeneic stem cell transplantation. Eight years later MCAS, likely underlying most of her chronic issues, was identified. CASE 2: A 30-year-old chronically polymorbid woman presented with superior vena cava syndrome and was diagnosed with ScM. On further evaluation, MCAS was identified. Treatment promptly effected symptomatic improvement; sclerosis has been stable. Non-compliance yielded symptomatic relapse; restored compliance re-achieved symptomatic remission. Different MCAS presentations reflect elaboration of different mediators, some of which can induce inflammation and fibrosis. Thus, MCAS may have directly and/or indirectly driven ScM in these patients. MCAS should be considered in ScM presenting with comorbidities better explained by mast cell mediator release. Copyright © 2012 Elsevier GmbH. All rights reserved.

  9. P2 receptor-mediated signaling in mast cell biology

    OpenAIRE

    Bulanova, Elena; Bulfone-Paus, Silvia

    2009-01-01

    Mast cells are widely recognized as effector cells of allergic inflammatory reactions. They contribute to the pathogenesis of different chronic inflammatory diseases, wound healing, fibrosis, thrombosis/fibrinolysis, and anti-tumor immune responses. In this paper, we summarized the role of P2X and P2Y receptors in mast cell activation and effector functions. Mast cells are an abundant source of ATP which is stored in their granules and secreted upon activation. We discuss the contribution of ...

  10. Central nervous system mast cells in peripheral inflammatory nociception

    Directory of Open Access Journals (Sweden)

    Ellmeier Wilfried

    2011-06-01

    Full Text Available Abstract Background Functional aspects of mast cell-neuronal interactions remain poorly understood. Mast cell activation and degranulation can result in the release of powerful pro-inflammatory mediators such as histamine and cytokines. Cerebral dural mast cells have been proposed to modulate meningeal nociceptor activity and be involved in migraine pathophysiology. Little is known about the functional role of spinal cord dural mast cells. In this study, we examine their potential involvement in nociception and synaptic plasticity in superficial spinal dorsal horn. Changes of lower spinal cord dura mast cells and their contribution to hyperalgesia are examined in animal models of peripheral neurogenic and non-neurogenic inflammation. Results Spinal application of supernatant from activated cultured mast cells induces significant mechanical hyperalgesia and long-term potentiation (LTP at spinal synapses of C-fibers. Lumbar, thoracic and thalamic preparations are then examined for mast cell number and degranulation status after intraplantar capsaicin and carrageenan. Intradermal capsaicin induces a significant percent increase of lumbar dural mast cells at 3 hours post-administration. Peripheral carrageenan in female rats significantly increases mast cell density in the lumbar dura, but not in thoracic dura or thalamus. Intrathecal administration of the mast cell stabilizer sodium cromoglycate or the spleen tyrosine kinase (Syk inhibitor BAY-613606 reduce the increased percent degranulation and degranulated cell density of lumbar dural mast cells after capsaicin and carrageenan respectively, without affecting hyperalgesia. Conclusion The results suggest that lumbar dural mast cells may be sufficient but are not necessary for capsaicin or carrageenan-induced hyperalgesia.

  11. Serotonin of mast cell origin contributes to hippocampal function

    OpenAIRE

    Nautiyal, Katherine M.; Dailey, Christopher A.; Jahn, Jaquelyn L.; Rodriquez, Elizabeth; Son, Nguyen Hong; Jonathan V. Sweedler; Silver, Rae

    2012-01-01

    In the CNS, serotonin, an important neurotransmitter and trophic factor, is synthesized by both mast cells and neurons. Mast cells, like other immune cells, are born in the bone marrow and migrate to many tissues. We show that they are resident in the mouse brain throughout development and adulthood. Measurements based on capillary electrophoresis with native fluorescence detection indicate that a significant contribution of serotonin to the hippocampal milieu is associated with mast cell act...

  12. Wind-energy Science, Technology and Research (WindSTAR) Consortium: Curriculum, Workforce Development, and Education Plan Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Manwell, James [Univ. of Massachusetts, Amherst, MA (United States)

    2013-03-19

    The purpose of the project is to modify and expand the current wind energy curriculum at the University of Massachusetts Amherst and to develop plans to expand the graduate program to a national scale. The expansion plans include the foundational steps to establish the American Academy of Wind Energy (AAWE). The AAWE is intended to be a cooperative organization of wind energy research, development, and deployment institutes and universities across North America, whose mission will be to develop and execute joint RD&D projects and to organize high-level science and education in wind energy

  13. Serotonin of mast cell origin contributes to hippocampal function.

    Science.gov (United States)

    Nautiyal, Katherine M; Dailey, Christopher A; Jahn, Jaquelyn L; Rodriquez, Elizabeth; Son, Nguyen Hong; Sweedler, Jonathan V; Silver, Rae

    2012-08-01

    In the central nervous system, serotonin, an important neurotransmitter and trophic factor, is synthesized by both mast cells and neurons. Mast cells, like other immune cells, are born in the bone marrow and migrate to many tissues. We show that they are resident in the mouse brain throughout development and adulthood. Measurements based on capillary electrophoresis with native fluorescence detection indicate that a significant contribution of serotonin to the hippocampal milieu is associated with mast cell activation. Compared with their littermates, mast cell-deficient C57BL/6 Kit(W-sh/W-sh) mice have profound deficits in hippocampus-dependent spatial learning and memory and in hippocampal neurogenesis. These deficits are associated with a reduction in cell proliferation and in immature neurons in the dentate gyrus, but not in the subventricular zone - a neurogenic niche lacking mast cells. Chronic treatment with fluoxetine, a selective serotonin reuptake inhibitor, reverses the deficit in hippocampal neurogenesis in mast cell-deficient mice. In summary, the present study demonstrates that mast cells are a source of serotonin, that mast cell-deficient C57BL/6 Kit(W-sh/W-sh) mice have disrupted hippocampus-dependent behavior and neurogenesis, and that elevating serotonin in these mice, by treatment with fluoxetine, reverses these deficits. We conclude that mast cells contribute to behavioral and physiological functions of the hippocampus and note that they play a physiological role in neuroimmune interactions, even in the absence of inflammatory responses.

  14. Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms

    Science.gov (United States)

    Metz, Martin; Piliponsky, Adrian M.; Chen, Ching-Cheng; Lammel, Verena; Åbrink, Magnus; Pejler, Gunnar; Tsai, Mindy; Galli, Stephen J.

    2006-07-01

    Snake or honeybee envenomation can cause substantial morbidity and mortality, and it has been proposed that the activation of mast cells by snake or insect venoms can contribute to these effects. We show, in contrast, that mast cells can significantly reduce snake-venom-induced pathology in mice, at least in part by releasing carboxypeptidase A and possibly other proteases, which can degrade venom components. Mast cells also significantly reduced the morbidity and mortality induced by honeybee venom. These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms.

  15. Commensal bacteria promote migration of mast cells into the intestine.

    Science.gov (United States)

    Kunii, Junichi; Takahashi, Kyoko; Kasakura, Kazumi; Tsuda, Masato; Nakano, Kou; Hosono, Akira; Kaminogawa, Shuichi

    2011-06-01

    Mast cells differentiate from hematopoietic stem cells in the bone marrow and migrate via the circulation to peripheral tissues, where they play a pivotal role in induction of both innate and adaptive immune responses. In this study, the effect of intestinal commensal bacteria on the migration of mast cells into the intestine was investigated. Histochemical analyses showed that germ-free (GF) mice had lower mast cell densities in the small intestine than normal mice. It was also shown that GF mice had lower mast cell proportion out of lamina propria leukocytes in the small intestine and higher mast cell percentages in the blood than normal mice by flow cytometry. These results indicate that migration of mast cells from the blood to the intestine is promoted by intestinal commensal bacteria. In addition, MyD88⁻/⁻ mice had lower densities of intestinal mast cells than CV mice, suggesting that the promotive effect of commensals is, at least in part, TLR-dependent. The ligands of CXC chemokine receptor 2 (CXCR2), which is critical for homing of mast cells to the intestine, were expressed higher in intestinal tissues and in intestinal epithelial cells (IECs) of normal mice than in those of GF or MyD88⁻/⁻ mice. Collectively, it is suggested that commensals promote migration of mast cells into the intestine through the induction of CXCR2 ligands from IECs in a TLR-dependent manner.

  16. Developing a Curriculum for Information and Communications Technology Use in Global Health Research and Training: A Qualitative Study Among Chinese Health Sciences Graduate Students.

    Science.gov (United States)

    Ma, Zhenyu; Yang, Li; Yang, Lan; Huang, Kaiyong; Yu, Hongping; He, Huimin; Wang, Jiaji; Cai, Le; Wang, Jie; Fu, Hua; Quintiliani, Lisa; Friedman, Robert H; Xiao, Jian; Abdullah, Abu S

    2017-06-12

    Rapid development of information and communications technology (ICT) during the last decade has transformed biomedical and population-based research and has become an essential part of many types of research and educational programs. However, access to these ICT resources and the capacity to use them in global health research are often lacking in low- and middle-income country (LMIC) institutions. The aim of our study was to assess the practical issues (ie, perceptions and learning needs) of ICT use among health sciences graduate students at 6 major medical universities of southern China. Ten focus group discussions (FGDs) were conducted from December 2015 to March 2016, involving 74 health sciences graduate students studying at 6 major medical universities in southern China. The sampling method was opportunistic, accounting for the graduate program enrolled and the academic year. All FGDs were audio recorded and thematic content analysis was performed. Researchers had different views and arguments about the use of ICT which are summarized under six themes: (1) ICT use in routine research, (2) ICT-related training experiences, (3) understanding about the pros and cons of Web-based training, (4) attitudes toward the design of ICT training curriculum, (5) potential challenges to promoting ICT courses, and (6) related marketing strategies for ICT training curriculum. Many graduate students used ICT on a daily basis in their research to stay up-to-date on current development in their area of research or study or practice. The participants were very willing to participate in ICT courses that were relevant to their academic majors and would count credits. Suggestion for an ICT curriculum included (1) both organized training course or short lecture series, depending on the background and specialty of the students, (2) a mixture of lecture and Web-based activities, and (3) inclusion of topics that are career focused. The findings of this study suggest that a need exists

  17. SENDS criteria from the diversification of MAST procedures. Implementation of preoperative simulation; SENDS-Kriterien als Entwicklungstheorem der MAST-Prozeduren. Einfuehrung praeoperativer Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Rieger, B. [Universitaetsklinikum Carl Gustav Carus, Klinik und Poliklinik fuer Neurochirurgie, Dresden (Germany)

    2015-10-15

    Minimal access spinal technologies (MAST) lead to a diversification of surgical procedures, which requires careful selection of the procedure and outcome monitoring. For a rational selection of the procedure simulation, endoscopy, navigation, decompression and stabilization (SENDS) criteria can be derived from the development of the MAST procedures. Preoperative simulation has diagnostic and therapeutic values. The SENDS criteria can be verified indirectly via outcome control. Biomechanically meaningful diagnostic x-rays of the spinal segment to be surgically treated are currently carried out with the patient in inclination and reclination. Software-related preoperative simulation based on these x-ray images facilitates the selection and implementation of the MAST procedure. For preoperative simulation motion shots are needed in inclination, neutral position and reclination and the dimensions can be obtained using an x-ray ball or a computed tomography (CT) scan. The SENDS criteria are useful because established procedures based on these criteria reach a comparable outcome. Preoperative simulation appears to be a useful selection criterion. Preoperatively it is necessary to collate patient and segment information in order to provide each patient with individualized treatment. So far there is no evidence for a better outcome after preoperative simulation but a reduction of surgery time and intraoperative radiation exposure could already be demonstrated. Minimally invasive methods should be preferred if there is a comparable outcome. The establishment of new procedures has to be accompanied by the maintenance of a spine register. Minimally invasive surgical procedures should be individualized for each patient and segment. Mobility X-ray images should be prepared for use with the preoperative simulation as the information content significantly increases with respect to the MAST procedure. (orig.) [German] Die Minimal Access Spine Technology (MAST) fuehrt zur

  18. A Research of Objectives and Contents of Information and Technology Curriculum Based on Psychology of Learning%基于学习心理学的信息技术课程目标和内容的研究

    Institute of Scientific and Technical Information of China (English)

    赵春声

    2012-01-01

    以学习心理学理论为指导来探索学校教育中不同学科学习与教学的规律成为当代心理学与教育相结合的一大趋势。学习心理学拓展了学习心理学在中小学课程中运用的学科领域,促进教师将信息技术课程的学习与教学相结合,为创建心理学取向的信息技术教学论奠定基础。%It is a trend to investigate the learning and teaching rules in different disciplines under the guidance of psychology of learning in the integration of psychology and education. This article first analyzes the psychological base of "three-dimensional goals" of information technology curriculum, and then analyzes the content of information technology curriculum with the theory of learning classification. Finally, it proposes that the application of psychology of learning to information technology curriculum promotes the integration of psychology of learning and specific disciplines and lays the foundation for the construction of psychology-based information technology curriculum.

  19. The Changing Curriculum: Mathematics.

    Science.gov (United States)

    Davis, Robert B.

    In this 1967 booklet, influences of technology, the non-achiever and the culturally disadvantaged, and the revolt against formalism are discussed in relation to the modern mathematics curriculum. Some projects and school programs described include PLATO, the Nuffield Project, the Nova School Program, Advanced Placement Program, and teacher…

  20. K-6 Science Curriculum.

    Science.gov (United States)

    Blueford, J. R.; And Others

    A unified science approach is incorporated in this K-6 curriculum mode. The program is organized into six major cycles. These include: (1) science, math, and technology cycle; (2) universe cycle; (3) life cycle; (4) water cycle; (5) plate tectonics cycle; and (6) rock cycle. An overview is provided of each cycle's major concepts. The topic…

  1. Discussion of the Integration of Curriculum of Frequency Conversion Technology Teaching%变频技术一体化课程教学的探讨

    Institute of Scientific and Technical Information of China (English)

    范宝华

    2015-01-01

    Inverter technology is a basic course for automation specialty, is an emerging discipline, teaching has certain difficulty and learning. This article first analyzed the common problems in integrated curriculum "inverter technology", the significance and importance of the teaching of. Then expounds the specific reform measures on teaching materials, teachers, teaching content, teaching methods, teaching means and methods of assessment in the process of teaching. Practice has proved: using the new teaching method, integrated curriculum teaching new teaching methods is not only beneficial to the students' mastery of the theory of knowledge, but also for the students to improve industrial automation equipment, to adapt to the social development of industrial modernization, Shi Yingxin's assessment methods with non constant important role.%变频技术是自动化专业的基础课程,是一门不断发展的新兴学科,教与学都具有一定的难度。首先分析了变频技术一体化课程的重要性、意义和教学中存在的普遍问题。然后阐述了教学过程中对教材、教师、教学内容、教学方法、教学手段和考核方式的具体改革措施。实践证明,进行一体化课程教学采用新教学方法、新教学手段不仅有利于学生对理论知识的掌握,而且对于学生提高工业自动化设备认识,适应社会工业现代化发展、适应新的考核方式等有着非常重要的作用。

  2. RELIGION AND TECHNICAL AND SCIENTIFIC FORMATION: THE (NOT-PLACE OF RELIGION IN THE CURRICULUM OF A TECHNICAL COURSE AT THE FEDERAL INSTITUTE OF EDUCATION, SCIENCE AND TECHNOLOGY OF GOIÁS

    Directory of Open Access Journals (Sweden)

    Maria Aparecida de Castro

    2014-12-01

    Full Text Available This work presents an introductory analysis of (not-place of religion in the curriculum of professional technical and scientific institution. The question we ask is: religion should, or should not take place in the curriculum, on instruction process offered by a scientific and technological institution of education. Assess critically through literature the situation of religion in the curriculum of the Technical Course in Computer Science from the Federal Institute of Education, Science and Technology of Goiás (IFG - Campus Inhumas. The complexity of the object and the not exhaustive characteristic the research led us much more to raise questions and hypotheses on the subject, than giving answers. We made a brief assessment of the discussions on the changes because it passes education / schooling and the curriculum area in recent years, highlighting the presence of religion in this scenario. We emphasize that we do not discuss in this paper the thorny Religious Education theme in school curricula. What interests us is debating whether religion should be considered in preparing the curriculum of a technical and scientific education institution or, in the case of public education and secular toward the professionalization and acquisition of expertise, religion has not (and should not have place in the formation process.

  3. A Ten Year Retrospective Analysis of the Distribution, Use and Phenotypic Characteristics of the LAD2 Human Mast Cell Line

    Science.gov (United States)

    Kirshenbaum, Arnold S.; Petrik, Amy; Walsh, Rosemary; Kirby, Tara L.; Vepa, Sury; Wangsa, Danny; Ried, Thomas; Metcalfe, Dean D.

    2014-01-01

    Background In 2003, this laboratory published an account of the human mast cell line LAD (Laboratory of Allergic Diseases)2 that expressed FcεRI, responded to recombinant human stem cell factor (rhSCF) and resembled CD34+-derived human mast cells. LAD2 cells have now been distributed worldwide. To study the impact of this transfer, we analyzed the number of investigators receiving LAD2 cells and resulting publications. Methods Records maintained in our lab, the Technology Transfer and Intellectual Property Office and Office of Technology Transfer were reviewed for material transfer agreements (MTAs) and licensing agreements (LAs). Journals and impact factors were obtained from PubMed.gov by cross-referencing LAD2 and human mast cells from 2003 through November 2013. Results Over 300 MTAs and 40 LAs were approved. LAD2 cells were shipped to over 30 countries. Over 80 papers have been published in journals with impact factors from 1.31 to 13.21. Intended uses include the study of receptors, degranulation, and cell signaling. LAD2 cells continue to express described markers and have consistent FceR1 mediated degranulation. Conclusions Success of the LAD2 line reflects the demand for a human mast cell line in research, the uniqueness of this cell line, and that it continues to exhibit minimal variation from its original description. We hope that the awareness of the impact of this cell line on mast cell research will encourage others to develop and distribute other similar cell lines with additional characteristics so as to address the limitations of depending on the study of cultured human mast cells from tissues. PMID:25195635

  4. Executing and teaching science---The breast cancer genetics and technology-rich curriculum professional development studies of a science educator

    Science.gov (United States)

    Wragg, Regina E.

    This dissertation presents my explorations in both molecular biology and science education research. In study one, we determined the ADIPOQ and ADIPORI genotypes of 364 White and 148 Black BrCa patients and used dominant model univariate logistic regression analyses to determine individual SNP and haplotype associations with tumor or patient characteristics in a case-case comparison. We found twelve associations between individual SNPs and patient or tumor characteristics that impact BrCa prognosis. For example, the ADIPOQ rs1501299 C allele was associated with ER+ tumors (OR=4.73, p=0.001) among White women >50 years of age at their time of diagnosis. Also, the A allele was more frequent in the Black patient population among whom more aggressive subtypes are common. Similarly, the ADIPORI rs12733285 T allele was associated with both PR+ and ER+ tumors. (OR=2.18 p=0.001; OR=1.88 p=0.019, respectively). Our data suggest that several polymorphisms individually or as specific ADIPOQ and ADIPOR1 haplotypes are associated with tumor characteristics that impact prognosis in BrCa patients. Thus, genotyping additional groups of patients for these SNPs could offer insight into the involvement of adiponectin signaling allele variance in BrCa outcomes. In our second study, we examined 1) how teachers' beliefs about themselves and their students influence the fidelity of implementation of their enactment of a technology-rich curriculum, and 2) how professional development support during the enactment leads to changes in teacher beliefs. From the analysis of two teachers' experiences through interviews, surveys, journal entries, and video recordings of their enactments, several different themes were identified. For example, teachers' beliefs regarding students' ability to learn using the curriculum influenced the fidelity of implementation and student learning. These observations led to the development of a model of professional development that would promote faithful

  5. Mast cells and angiogenesis in primary and recurrent pterygia

    Directory of Open Access Journals (Sweden)

    Fatma Hüsniye DİLEK

    2007-09-01

    Full Text Available Pterygium is a common benign lesion of limbus but the pathogenesis are not completely understood. Pterygia have a chronic inflammatory cellular infiltrate and a rich vasculature. Mast cells are a heterogeneous group of multifunctional tissue-resident cells. It has been suggested that mast cells and their products may be responsible for the formation of new blood vessels. We investigated the number and phenotype of mast cells and neovascularization in pterygia specimens and compared with those in normal conjunctival specimensPterygia tissues were obtained during excisional surgery from 32 eyes of 32 consecutive patients. Seventeen of all cases were recurrent pterygia. Superior bulbar conjunctival tissue from the same eye was also sampled as control tissues. The tissue sections were stained with routine hematoxyline-eosin and toluidine blue stain for mast cells. For immunohistochemical studies anti-factor VIII-related antigen, monoclonal anti human mast cell tryptase and chymase were used as an endothelial and mast cell marker.The mean number of mast cells in pterygia was significantly higher than that in the normal conjunctival tissue and microvessel counts was significantly higher than the counts of the controls in both primary and recurrent pterygia. There was no correlation between microvessel numbers and mast cell numbers. There was no phenotypic difference between the mast cells in the ptergyia and those in the normal conjunctival tissues.This study confirms that mast cells are prominent in pterygia and our results suggest that mast cells and angiogenesis are independent factors in the genesis and progress of ptergyium.

  6. Concerns of Teachers about the Implementation of Information and Communication Technology Curriculum in Basic Education in Ghana

    Science.gov (United States)

    Sarfo, Frederick Kwaku; Amankwah, Francis; Baafi-Frimpong, Stephen; Asomani, Joseph

    2017-01-01

    Research findings in the literature show that teachers' concern about change process is extremely personal and it influences the implementation of innovation. This study aimed at assessing information and communication technology teachers' stages of concern regarding the implementation of information and communication technology (ICT) curriculum…

  7. Reform of School Science Curriculum for the 21st Century: Science-Technology-Society Theme in Japanese Context.

    Science.gov (United States)

    Nakayama, Genzo

    Today, on the eve of the 21st century, Japan is becoming an internationalized, information centered civilization. The sophistication of modern science and technology will create a demand for people who are highly productive in handling knowledge and sensitive in their manipulation of it. This advance of science and technology will also require an…

  8. Measuring histamine and cytokine release from basophils and mast cells

    DEFF Research Database (Denmark)

    Jensen, Bettina M; Falkencrone, Sidsel; Skov, Per S

    2014-01-01

    Basophils and mast cells are known for their capability to release both preformed and newly synthesized inflammatory mediators. In this chapter we describe how to stimulate and detect histamine released from basophils in whole blood, purified basophils, in vitro cultured mast cells, and in situ...

  9. Non-IgE mediated mast cell activation

    NARCIS (Netherlands)

    Yu, Yingxin; Blokhuis, Bart R; Garssen, Johan; Redegeld, Frank A

    2016-01-01

    Mast cells are crucial effector cells in allergic reactions, where IgE is the best known mechanism to trigger their degranulation and release of a vast array of allergic mediators. However, IgE is not the only component to stimulate these cells to degranulate, while mast cell activation can also res

  10. Mast cell synapses and exosomes: membrane contacts for information exchange.

    NARCIS (Netherlands)

    Carroll-Portillo, A.; Surviladze, Z.; Cambi, A.; Lidke, D.S.; Wilson, B.S.

    2012-01-01

    In addition to their central role in allergy, mast cells are involved in a wide variety of cellular interactions during homeostasis and disease. In this review, we discuss the ability of mast cells to extend their mechanisms for intercellular communication beyond the release of soluble mediators. Th

  11. Damage Assessment of a Steel Lattice Mast under Natural Excitation

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Rytter, A.

    1994-01-01

    In this paper the possibility of detecting and locating damages in a 20 m high steel lattice mast subjected to natural excitation has been investigated. For the damaged mast seven different damage states were considered. In these damage states a damage was assumed in one of the lower diagonals...

  12. Mechanism of mast cell adhesion to human tenocytes in vitro.

    Science.gov (United States)

    Behzad, Hayedeh; Tsai, Shu-Huei; Nassab, Paulina; Mousavizadeh, Rouhollah; McCormack, Robert G; Scott, Alex

    2015-01-01

    Mast cells and fibroblasts are two key players involved in many fibrotic and degenerative disorders. In the present study we examined the nature of binding interactions between human mast cells and tendon fibroblasts (tenocytes). In the mast cell-fibroblast co-culture model, mast cells were shown to spontaneously bind to tenocytes, in a process that was partially mediated by α5β1 integrin receptors. The same receptors on mast cells significantly mediated binding of these cells to tissue culture plates in the presence of tenocyte-conditioned media; the tenocyte-derived fibronectin in the media was shown to also play a major role in these binding activities. Upon binding to tenocytes or tissue culture plates, mast cells acquired an elongated phenotype, which was dependent on α5β1 integrin and tenocyte fibronectin. Additionally, tenocyte-derived fibronectin significantly enhanced mRNA expression of the adhesion molecule, THY1, by mast cells. Our data suggests that α5β1 integrin mediates binding of mast cells to human tenocyte and to tenocyte-derived ECM proteins, in particular fibronectin.

  13. Mast cell function: a new vision of an old cell.

    Science.gov (United States)

    da Silva, Elaine Zayas Marcelino; Jamur, Maria Célia; Oliver, Constance

    2014-10-01

    Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as effectors of allergy. It has been only in the past two decades that mast cells have gained recognition for their involvement in other physiological and pathological processes. Mast cells have a widespread distribution and are found predominantly at the interface between the host and the external environment. Mast cell maturation, phenotype and function are a direct consequence of the local microenvironment and have a marked influence on their ability to specifically recognize and respond to various stimuli through the release of an array of biologically active mediators. These features enable mast cells to act as both first responders in harmful situations as well as to respond to changes in their environment by communicating with a variety of other cells implicated in physiological and immunological responses. Therefore, the critical role of mast cells in both innate and adaptive immunity, including immune tolerance, has gained increased prominence. Conversely, mast cell dysfunction has pointed to these cells as the main offenders in several chronic allergic/inflammatory disorders, cancer and autoimmune diseases. This review summarizes the current knowledge of mast cell function in both normal and pathological conditions with regards to their regulation, phenotype and role.

  14. Norsewind - array of wind lidars and meteorological masts offshore

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Detlef Stein, F. P.; Hagemann, Saskia;

    The FP7 project Norsewind (2008-2012) focused on the offshore study of winds through observations with ground-based wind lidars, meteorological masts and satellite remote sensors, and mesoscale modeling. Some results of the observational array of wind lidars and meteorological masts are presented....

  15. The validity of the Michigan Alcoholism Screening Test (MAST)

    DEFF Research Database (Denmark)

    Storgaard, H; Nielsen, S D; Gluud, C

    1994-01-01

    This review examines the validity of the Michigan Alcoholism Screening Test (MAST) as a screening instrument for alcohol problems. Studies that compare the MAST-questionnaire with other defined diagnostic criteria of alcohol problems were retrieved through MEDLINE and a cross-bibliographic check...

  16. Involvement of mast cells in adipose tissue fibrosis.

    Science.gov (United States)

    Hirai, Shizuka; Ohyane, Chie; Kim, Young-Il; Lin, Shan; Goto, Tsuyoshi; Takahashi, Nobuyuki; Kim, Chu-Sook; Kang, Jihey; Yu, Rina; Kawada, Teruo

    2014-02-01

    Recently, fibrosis is observed in obese adipose tissue; however, the pathogenesis remains to be clarified. Obese adipose tissue is characterized by chronic inflammation with massive accumulation of immune cells including mast cells. The objective of the present study was to clarify the relationship between fibrosis and mast cells in obese adipose tissue, as well as to determine the origin of infiltrating mast cells. We observed the enhancement of mast cell accumulation and fibrosis in adipose tissue of severely obese diabetic db/db mice. Furthermore, adipose tissue-conditioned medium (ATCM) from severely obese diabetic db/db mice significantly enhanced collagen 5 mRNA expression in NIH-3T3 fibroblasts, and this enhancement was suppressed by the addition of an anti-mast cell protease 6 (MCP-6) antibody. An in vitro study showed that only collagen V among various types of collagen inhibited preadipocyte differentiation. Moreover, we found that ATCM from the nonobese but not obese stages of db/db mice significantly enhanced the migration of bone marrow-derived mast cells (BMMCs). These findings suggest that immature mast cells that infiltrate into adipose tissue at the nonobese stage gradually mature with the progression of obesity and diabetes and that MCP-6 secreted from mature mast cells induces collagen V expression in obese adipose tissue, which may contribute to the process of adipose tissue fibrosis. Induction of collagen V by MCP-6 might accelerate insulin resistance via the suppression of preadipocyte differentiation.

  17. The presence of ANP in rat peritoneal mast cells

    Institute of Scientific and Technical Information of China (English)

    Marina G MARTYNOVA; Olga A BYSTROVA; Olga M MOISEEVA; Anton L EVDONIN; Kirill A KONDRATOV; Natalja D MEDVEDEVA

    2005-01-01

    Atrial natriuretic peptide (ANP) is an important component of the natriuretic peptide system. A great role in many regulatory systems is played by mast cells. Meanwhile involvement of these cells in ANP activity is poorly studied. In this work, we have shown the presence of ANP in rat peritoneal mast cells. Pure fraction of mast cells was obtained by separation of rat peritoneal cells on a Percoll density gradient. By Western blotting, two ANP-immunoreactive proteins of molecular masses of 2.5 kDa and 16.9 kDa were detected in lysates from these mast cells. Electron microscope immunogold labeling has revealed the presence of ANP-immunoreactive material in storage, secreting and released granules of mast cells. Our findings indicate the rat peritoneal mast cells to contain both ANP prohormone and ANP. These both peptides are located in mast cell secretory granules and released by mechanism of degranulation. It is discussed that many mast cell functions might be due to production of natriuretic peptides by these cells.

  18. Non-IgE mediated mast cell activation

    NARCIS (Netherlands)

    Yu, Yingxin; Blokhuis, Bart R; Garssen, Johan; Redegeld, Frank A

    2015-01-01

    Mast cells are crucial effector cells in allergic reactions, where IgE is the best known mechanism to trigger their degranulation and release of a vast array of allergic mediators. However, IgE is not the only component to stimulate these cells to degranulate, while mast cell activation can also res

  19. International Curriculums.

    Science.gov (United States)

    Neal, Larry L.

    This workshop presentation on international curriculums in the field of parks, recreation, leisure, cultural services, and travel/tourism comments that the literature is replete with articles addressing what the field is about, but not about curriculum issues, models, and structure. It reports an international survey of 12 college educators…

  20. The mast cell: a neuroimmunoendocrine master player.

    Science.gov (United States)

    Theoharides, T C

    1996-01-01

    This review of the literature on mast cells (MC) suggests that when activated they may play a central role in disease syndromes with a neural, immune and endocrine component exacerbated under stress. After a discussion of their biology, differential secretions and interaction with neurons, the effect of stress in causing MC degranulation is emphasized. The importance of MC in syndromes such as migraine, multiple sclerosis, interstitial cystitis and irritable bowel syndrome is assessed, along with possible therapeutic possibilities with compounds that inhibit MC activation.

  1. Modelling and Analysis Capabilities for Lightweight Masts

    Science.gov (United States)

    2001-02-01

    needed in DREA’s VAST finite element code in order to be able to analyse composite mast structures. Future Plans The second phase of this...résultats Les travaux effectués pour ce projet fournissent la base du développement futur de l’outil de modélisation MASTAS des exercices financiers...pouvoir analyser les structures des mâts composites. Projets futurs La deuxième phase de ce projet d’application de technologie est actuellement en

  2. Stereological quantification of mast cells in human synovium

    DEFF Research Database (Denmark)

    Damsgaard, T E; Sørensen, Flemming Brandt; Herlin, T;

    1999-01-01

    Mast cells participate in both the acute allergic reaction as well as in chronic inflammatory diseases. Earlier studies have revealed divergent results regarding the quantification of mast cells in the human synovium. The aim of the present study was therefore to quantify these cells in the human...... synovium, using stereological techniques. Different methods of staining and quantification have previously been used for mast cell quantification in human synovium. Stereological techniques provide precise and unbiased information on the number of cell profiles in two-dimensional tissue sections of......, in this case, human synovium. In 10 patients suffering from osteoarthritis a median of 3.6 mast cells/mm2 synovial membrane was found. The total number of cells (synoviocytes, fibroblasts, lymphocytes, leukocytes) present was 395.9 cells/mm2 (median). The mast cells constituted 0.8% of all the cell profiles...

  3. Human mast cell tryptase in biology and medicine.

    Science.gov (United States)

    Vitte, Joana

    2015-01-01

    The most abundant prestored enzyme of human mast cell secretory granules is the serine-protease tryptase. In humans, there are four tryptase isoforms, but only two of them, namely the alpha and beta tryptases, are known as medically important. Low levels of continuous tryptase production as an immature monomer makes up the major part of the baseline serum tryptase levels, while transient release of mature tetrameric tryptase upon mast cell degranulation accounts for the anaphylactic rise of serum tryptase levels. Serum tryptase determination contributes to the diagnosis or monitoring of mast cell disorders including mast cell activation - induced anaphylaxis, mastocytosis and a number of myeloproliferative conditions with mast cell lineage involvement. Baseline serum tryptase levels are predictive of the severity risk in some allergic conditions.

  4. Mast cell function modulating IgE-mediated allergy

    Directory of Open Access Journals (Sweden)

    Ruby Pawankar

    1999-01-01

    Full Text Available Allergic diseases, such as atopic rhinitis, bronchial asthma and urticaria, are prevalent and increasing in frequency. Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators, such as histamine, leukotrienes and prostaglandins. In contrast, T lymphocytes, basophils and eosinophils are thought to be responsible for inducing the late phase response. However, whether the mast cell can be simplistically assigned a role in the immediate phase allergic response and whether mast cells are necessary for the ongoing allergic response, including the development of hyperresponsiveness, remains to be completely studied. In the present article, the author will discuss the integrated roles of mast cells in IgE-mediated allergic inflammation, with specific emphasis on the roles of mast cell-derived cytokines in the late phase allergic response and chronic allergic inflammation.

  5. Thymus involution in alloxan diabetes: analysis of mast cells

    Directory of Open Access Journals (Sweden)

    EO Barreto

    2005-03-01

    Full Text Available We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.

  6. The impact of mast cells on cardiovascular diseases.

    Science.gov (United States)

    Kritikou, Eva; Kuiper, Johan; Kovanen, Petri T; Bot, Ilze

    2016-05-05

    Mast cells comprise an innate immune cell population, which accumulates in tissues proximal to the outside environment and, upon activation, augments the progression of immunological reactions through the release and diffusion of either pre-formed or newly generated mediators. The released products of mast cells include histamine, proteases, as well as a variety of cytokines, chemokines and growth factors, which act on the surrounding microenvironment thereby shaping the immune responses triggered in various diseased states. Mast cells have also been detected in the arterial wall and are implicated in the onset and progression of numerous cardiovascular diseases. Notably, modulation of distinct mast cell actions using genetic and pharmacological approaches highlights the crucial role of this cell type in cardiovascular syndromes. The acquired evidence renders mast cells and their mediators as potential prognostic markers and therapeutic targets in a broad spectrum of pathophysiological conditions related to cardiovascular diseases.

  7. Lung mast cells and hypoxic pulmonary vasoconstriction in cats

    Energy Technology Data Exchange (ETDEWEB)

    Martin, L.F.; Tucker, A.; Munroe, M.L.; Reeves, J.T.

    1978-01-01

    An attempt was made to reduce or eliminate lung mast cells in order to determine the involvement of mast cells in hypoxic pulmonary vasoconstriction. Anesthetized cats were exposed to acute hypoxia (10% O/sub 2/) 20 to 24 h after no pretreatment, after total lung irradiation (3,000 r), after intravenous nitrogen mustard, or after combined lung irradiation and nitrogen mustard. None of the treatments reduced total or perivascular lung mast cell density, or reduced the pulmonary vasoconstrictor response to hypoxia. However, an inverse relationship between lung mast cell density and the pulmonary pressor response to hypoxia was observed. These results suggest that the presence of more lung mast cells may oppose hypoxic pulmonary vasoconstriction.

  8. Study of mast cell count in skin tags

    Directory of Open Access Journals (Sweden)

    Zaher Hesham

    2007-01-01

    Full Text Available Background: Skin tags or acrochordons are common tumors of middle-aged and elderly subjects. They consist of loose fibrous tissue and occur mainly on the neck and major flexures as small, soft, pedunculated protrusions. Objectives: The aim was to compare the mast cells count in skin tags to adjacent normal skin in diabetic and nondiabetic participants in an attempt to elucidate the possible role of mast cells in the pathogenesis of skin tags. Participants and Methods: Thirty participants with skin tags were divided into group I (15 nondiabetic participants and group II (15 diabetic participants. Three biopsies were obtained from each participant: a large skin tag, a small skin tag and adjacent normal skin. Mast cell count from all the obtained sections was carried out, and the mast cell density was expressed as the average mast cell count/high power field (HPF. Results: A statistically significant increase in mast cells count in skin tags in comparison to normal skin was detected in group I and group II. There was no statistically significant difference between mast cell counts in skin tags of both the groups. Conclusion: Both the mast cell mediators and hyperinsulinemia are capable of inducing fibroblast proliferation and epidermal hyperplasia that are the main pathologic abnormalities seen in all types of skin tags. However, the presence of mast cells in all examined skin tags regardless of diabetes and obesity may point to the possible crucial role of mast cells in the etiogenesis of skin tags through its interaction with fibroblasts and keratinocytes.

  9. Herramientas Informativas para la Vigilancia Tecnológica en Diseños Curriculares de Universidades Públicas (Information Tools for Technological Monitoring on State University Curriculum Design

    Directory of Open Access Journals (Sweden)

    Karela Paola González Hidalgo

    2013-11-01

    Full Text Available Resumen Con esta investigación se planteó establecer las herramientas informativas para la vigilancia tecnológica en diseños curriculares de universidades públicas, para lo cual se analizaron las bases de datos, la cienciometría y SERBILUZ en el Núcleo Técnico de la Universidad del Zulia, mediante un estudio no experimental transeccional descriptivo y de campo. De acuerdo con las herramientas informativas estudiadas, se observa que los informantes claves desconocen si dentro de la universidad se cuenta con este tipo de estadística y registro que le permitan a la comisión curricular de la institución tener información sobre las estrategias utilizadas en los procesos de transformación curricular anteriores que permitan ver cómo han evolucionado las competencias necesarias o requeridas por el sector productivo nacional. Así mismo, se desconoce si SERBILUZ maneja sistema de gestión documental de la información con respecto a los procesos curriculares que faciliten la toma de decisiones. A pesar de esta data recopilada, se percibe que actualmente se está llevando a cabo un registro de la información recolectada en este proceso de transformación y todos los análisis de la misma, que servirá de referencia para los próximos procesos curriculares. Abstract This research aims to determine the tools for technological monitoring in public university curricula, for which we analyzed database, scientometrics and SERBILUZ at the Technical University of Zulia using a non- experimental descriptive field study. According to the information tools under study, key informants are not aware of the existence of statistics and records to obtain information about the strategies used in the transformation processes prior to the curriculum. These are key to understand how the skills required by the national productive sector have been developed. Also, there is no clear information about whether SERBILUZ manages the information management system

  10. Rethinking the mathematics curriculum

    CERN Document Server

    Hoyles, Celia; Woodhouse, Geoffrey

    1998-01-01

    At a time when political interest in mathematics education is at its highest, this book demonstrates that the issues are far from straightforward. A wide range of international contributors address such questions as: What is mathematics, and what is it for? What skills does mathematics education need to provide as technology advances? What are the implications for teacher education? What can we learn from past attempts to change the mathematics curriculum? Rethinking the Mathematics Curriculum offers stimulating discussions, showing much is to be learnt from the differences in culture, national expectations, and political restraints revealed in the book. This accessible book will be of particular interest to policy makers, curriculum developers, educators, researchers and employers as well as the general reader.

  11. The Impact of High School Principal's Technology Leadership on the Sustainability of Corporate Sponsored Information Communication Technology Curriculum

    Science.gov (United States)

    Gottwig, Bruce Ryan

    2013-01-01

    The proliferation of information communication technology (ICT) has placed educational institutions in the forefront in educating and training students as skilled consumers, engineers, and technicians of this widely used technology. Corporations that develop and use ICT are continually building a skilled workforce; however, because of the growth…

  12. Introduction of CAA into a mathematics course for technology students to address a change in curriculum requirements

    OpenAIRE

    Pollock, M.J.

    2002-01-01

    The mathematical requirements for engineering, science and technology students has been debated for many years and concern has been expressed about the mathematical preparedness of students entering higher education. This paper considers a mathematics course that has been specifically designed to address some of these issues for technology education students. It briefly chronicles the changes that have taken place over its lifetime and evaluates the introduction of Computer Assisted Assessmen...

  13. Overview of recent physics results from MAST

    CERN Document Server

    Kirk, A; Akers, RJ; Allan, S; Appel, L; Lucini, F Arese; Barnes, M; Barrett, T; Ayed, N Ben; Boeglin, W; Bradley, J; Browning, P K; Brunner, J; Cahyna, P; Carr, M; Casson, F; Cecconello, M; Challis, C; Chapman, IT; Chapman, S; Conroy, S; Conway, N; Cooper, WA; Cox, M; Crocker, N; Crowley, B; Cardnell, S; Chorley, J; Cunningham, G; Danilov, A; Darrow, D; Dendy, R; Dickinson, D; Dorland, W; Dudson, B; Easy, L; Elmore, S; Evans, M; Farley, T; Fedorczak, N; Field, A; Fitzgerald, I; Fox, M; Freethy, S; Garzotti, L; Ghim, YC; Gi, K; Gorelenkova, M; Gracias, W; Gurl, C; Guttenfelder, W; Ham, C; Harting, D; Havlickova, E; Hawkes, N; Hender, T; Henderson, S; Hillesheim, J; Hnat, B; Horacek, J; Howard, J; Howell, D; Dunai, D; Fishpool, G; Gibson, K; Harrison, J; Highcock, E; Huang, B; Inomoto, M; Imazawa, R; Jones, O; Kadowaki, K; Kaye, S; Keeling, D; Kocan, M; Kogan, L; Komm, M; Lai, W; Leddy, J; Leggate, H; Imada, K; Klimek, I; Hollocombe, J; Lipschultz, B; Lisgo, S; Liu, YQ; Lloyd, B; Lomanowski, B; Lukin, V; Maddison, G; Madsen, J; Mailloux, J; Martin, R; McArdle, G; Lupelli, I; McClements, K; McMillan, B; Meakins, A; Meyer, H; Michael, C; Militello, F; Milnes, J; Motojima, G; Muir, D; Naylor, G; Nielsen, A; O'Brien, M; O'Mullane, M; Olsen, J; Omotani, J; Ono, Y; Pamela, S; Morris, AW; O'Gorman, T; Pangione, L; Parra, F; Patel, A; Peebles, W; Perez, R; Pinches, S; Piron, L; Price, M; Reinke, M; Ricci, P; Riva, F; Roach, C; Romanelli, M; Ryan, D; Saarelma, S; Saveliev, A; Scannell, R; Schekochihin, A; Sharapov, S; Sharples, R; Shevchenko, V; Shinohara, K; Silburn, S; Simpson, J; Stanier, A; Storrs, J; Summers, H; Takase, Y; Tamain, P; Tanabe, H; Tanaka, H; Tani, K; Taylor, D; Thomas, D; Thomas-Davies, N; Thornton, A; Turnyanskiy, M; Valovic, M; Vann, R; Van Wyk, F; Walkden, N; Watanabe, T; Wilson, H; Wischmeier, M; Yamada, T; Young, J; Zoletnik, S

    2016-01-01

    New results from MAST are presented that focus on validating models in order to extrapolate to future devices. Measurements during start-up experiments have shown how the bulk ion temperature rise scales with the square of the reconnecting field. During the current ramp up models are not able to correctly predict the current diffusion. Experiments have been performed looking at edge and core turbulence. At the edge detailed studies have revealed how filament characteristic are responsible for determining the near and far SOL density profiles. In the core the intrinsic rotation and electron scale turbulence have been measured. The role that the fast ion gradient has on redistributing fast ions through fishbone modes has led to a redesign of the neutral beam injector on MAST Upgrade. In H-mode the turbulence at the pedestal top has been shown to be consistent with being due to electron temperature gradient modes. A reconnection process appears to occur during ELMs and the number of filaments released determines...

  14. SOL Width Scaling in the MAST Tokamak

    Science.gov (United States)

    Ahn, Joon-Wook; Counsell, Glenn; Connor, Jack; Kirk, Andrew

    2002-11-01

    Target heat loads are determined in large part by the upstream SOL heat flux width, Δ_h. Considerable effort has been made in the past to develop analytical and empirical scalings for Δh to allow reliable estimates to be made for the next-step device. The development of scalings for a large spherical tokamak (ST) such as MAST is particularly important both for development of the ST concept and for improving the robustness of scalings derived for conventional tokamaks. A first such scaling has been developed in MAST DND plasmas. The scaling was developed by flux-mapping data from the target Langmuir probe arrays to the mid-plane and fitting to key upstream parameters such as P_SOL, bar ne and q_95. In order to minimise the effects of co-linearity, dedicated campaigns were undertaken to explore the widest possible range of each parameter while keeping the remainder as fixed as possible. Initial results indicate a weak inverse dependence on P_SOL and approximately linear dependence on bar n_e. Scalings derived from consideration of theoretical edge transport models and integration with data from conventional devices is under way. The established scaling laws could be used for the extrapolations to the future machine such as Spherical Tokamak Power Plant (STPP). This work is jointly funded by Euratom and UK Department of Trade and Industry. J-W. Ahn would like to recognise the support of a grant from the British Foreign & Commonwealth Office.

  15. Mast cell distribution in normal adult skin.

    Science.gov (United States)

    Janssens, A S; Heide, R; den Hollander, J C; Mulder, P G M; Tank, B; Oranje, A P

    2005-03-01

    To investigate mast cell distribution in normal adult skin to provide a reference range for comparison with mastocytosis. Mast cells (MCs) were counted in uninvolved skin adjacent to basal cell carcinomas and other dermatological disorders in adults. There was an uneven distribution of MCs in different body sites using the anti-tryptase monoclonal antibody technique. Numbers of MCs on the trunk, upper arm, and upper leg were similar, but were significantly different from those found on the lower leg and forearm. Two distinct groups were formed--proximal and distal. There were 77.0 MCs/mm2 at proximal body sites and 108.2 MCs/mm2 at distal sites. Adjusted for the adjacent diagnosis and age, this difference was consistent. The numbers of MCs in uninvolved skin adjacent to basal cell carcinomas and other dermatological disorders were not different from those in the control group. Differences in the numbers of MCs between the distal and the proximal body sites must be considered when MCs are counted for a reliable diagnosis of mastocytosis. A pilot study in patients with mastocytosis underlined the variation in the numbers of MCs in mastocytosis and normal skin, but showed a considerable overlap. The observed numbers of MCs in adults cannot be extrapolated to children. MC numbers varied significantly between proximal and distal body sites and these differences must be considered when MCs are counted for a reliable diagnosis of mastocytosis. There was a considerable overlap between the numbers of MCs in mastocytosis and normal skin.

  16. Overview of recent physics results from MAST

    Science.gov (United States)

    Kirk, A.; Adamek, J.; Akers, R. J.; Allan, S.; Appel, L.; Arese Lucini, F.; Barnes, M.; Barrett, T.; Ben Ayed, N.; Boeglin, W.; Bradley, J.; Browning, P. K.; Brunner, J.; Cahyna, P.; Cardnell, S.; Carr, M.; Casson, F.; Cecconello, M.; Challis, C.; Chapman, I. T.; Chapman, S.; Chorley, J.; Conroy, S.; Conway, N.; Cooper, W. A.; Cox, M.; Crocker, N.; Crowley, B.; Cunningham, G.; Danilov, A.; Darrow, D.; Dendy, R.; Dickinson, D.; Dorland, W.; Dudson, B.; Dunai, D.; Easy, L.; Elmore, S.; Evans, M.; Farley, T.; Fedorczak, N.; Field, A.; Fishpool, G.; Fitzgerald, I.; Fox, M.; Freethy, S.; Garzotti, L.; Ghim, Y. C.; Gi, K.; Gibson, K.; Gorelenkova, M.; Gracias, W.; Gurl, C.; Guttenfelder, W.; Ham, C.; Harrison, J.; Harting, D.; Havlickova, E.; Hawkes, N.; Hender, T.; Henderson, S.; Highcock, E.; Hillesheim, J.; Hnat, B.; Horacek, J.; Howard, J.; Howell, D.; Huang, B.; Imada, K.; Inomoto, M.; Imazawa, R.; Jones, O.; Kadowaki, K.; Kaye, S.; Keeling, D.; Klimek, I.; Kocan, M.; Kogan, L.; Komm, M.; Lai, W.; Leddy, J.; Leggate, H.; Hollocombe, J.; Lipschultz, B.; Lisgo, S.; Liu, Y. Q.; Lloyd, B.; Lomanowski, B.; Lukin, V.; Lupelli, I.; Maddison, G.; Madsen, J.; Mailloux, J.; Martin, R.; McArdle, G.; McClements, K.; McMillan, B.; Meakins, A.; Meyer, H.; Michael, C.; Militello, F.; Milnes, J.; Morris, A. W.; Motojima, G.; Muir, D.; Naylor, G.; Nielsen, A.; O'Brien, M.; O'Gorman, T.; O'Mullane, M.; Olsen, J.; Omotani, J.; Ono, Y.; Pamela, S.; Pangione, L.; Parra, F.; Patel, A.; Peebles, W.; Perez, R.; Pinches, S.; Piron, L.; Price, M.; Reinke, M.; Ricci, P.; Riva, F.; Roach, C.; Romanelli, M.; Ryan, D.; Saarelma, S.; Saveliev, A.; Scannell, R.; Schekochihin, A.; Sharapov, S.; Sharples, R.; Shevchenko, V.; Shinohara, K.; Silburn, S.; Simpson, J.; Stanier, A.; Storrs, J.; Summers, H.; Takase, Y.; Tamain, P.; Tanabe, H.; Tanaka, H.; Tani, K.; Taylor, D.; Thomas, D.; Thomas-Davies, N.; Thornton, A.; Turnyanskiy, M.; Valovic, M.; Vann, R.; Van Wyk, F.; Walkden, N.; Watanabe, T.; Wilson, H.; Wischmeier, M.; Yamada, T.; Young, J.; Zoletnik, S.; the MAST Team; the EUROfusion MST1 Team

    2017-10-01

    New results from MAST are presented that focus on validating models in order to extrapolate to future devices. Measurements during start-up experiments have shown how the bulk ion temperature rise scales with the square of the reconnecting field. During the current ramp-up, models are not able to correctly predict the current diffusion. Experiments have been performed looking at edge and core turbulence. At the edge, detailed studies have revealed how filament characteristics are responsible for determining the near and far scrape off layer density profiles. In the core the intrinsic rotation and electron scale turbulence have been measured. The role that the fast ion gradient has on redistributing fast ions through fishbone modes has led to a redesign of the neutral beam injector on MAST Upgrade. In H-mode the turbulence at the pedestal top has been shown to be consistent with being due to electron temperature gradient modes. A reconnection process appears to occur during edge localized modes (ELMs) and the number of filaments released determines the power profile at the divertor. Resonant magnetic perturbations can mitigate ELMs provided the edge peeling response is maximised and the core kink response minimised. The mitigation of intrinsic error fields with toroidal mode number n  >  1 has been shown to be important for plasma performance.

  17. Addressing the challenges of a new digital technologies curriculum: MOOCs as a scalable solution for teacher professional development

    Directory of Open Access Journals (Sweden)

    Rebecca Vivian

    2014-08-01

    Full Text Available England and Australia have introduced new learning areas, teaching computer science to children from the first year of school. This is a significant milestone that also raises a number of big challenges: the preparation of teachers and the development of resources at a national scale. Curriculum change is not easy for teachers, in any context, and to ensure teachers are supported, scaled solutions are required. One educational approach that has gained traction for delivering content to large-scale audiences are massively open online courses (MOOCs; however, little is known about what constitutes effective MOOC design, particularly within professional development contexts. To prepare teachers in Australia, we decided to ride the wave of MOOCs, developing a MOOC to deliver free computing content and pedagogy to teachers with the integration of social media to support knowledge exchange and resource building. The MOOC was designed to meet teacher needs, allowing for flexibility, ad-hoc interactions, support and the open sharing of resources. In this paper, we describe the process of developing our initiative, participant engagement and experiences, so that others encountering similar changes and reforms may learn from our experience.

  18. 信息技术与大学生就业指导课程整合研究%Research on the Integration of Information Technology and College Students’Vocational Counsel Curriculum

    Institute of Scientific and Technical Information of China (English)

    李思思

    2016-01-01

    当前大学生就业指导课程存在诸多问题,需要进行改革从而使其有所改变。随着信息技术的发展,信息技术与课程整合成为大学生就业指导课程改革的一条较为有效的途径。通过对教师进行访谈,对学生进行问卷调查,本文分析信息技术与大学生就业指导课程整合的必要性和可行性,并提出课程整合的相关建议,以期促进大学生就业指导课程的发展。%At present, there are many problems about college students ’ vocational counsel curriculum and it needs to be reformed to make some changes.With the development of information technology,the integration of information technology and curriculum becomes a more effective way to reform college students’vocational counsel curriculum.This study conducts the necessity and feasibility of the integration of information technology and college students’vocational counsel curriculum through interviews with teachers and students’surveys by questionnaire,then proposes some relevant recom-mendations in order to promote the development of college students’vocational counsel curriculum.

  19. Histamine and TNF-α release by rat peritoneal mast cells stimulated with Trichomonas vaginalis

    Directory of Open Access Journals (Sweden)

    Im S.J.

    2011-02-01

    Full Text Available Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-α and histamine. Rat peritoneal mast cells (RPMC, a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-α. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.

  20. Mast Cells and IgE: From History to Today

    Directory of Open Access Journals (Sweden)

    Hirohisa Saito

    2013-01-01

    Full Text Available Role of mast cells in allergy had remained undetermined until the discovery of IgE in 1966. Then, IgE purified from many Liters of plasma, which had been donated from a patient with fatal myeloma, was distributed to researchers all over the world, and thus accelerated exploring the mechanisms involved in allergic reactions, particularly about the role of mast cells and basophils in the IgE-mediated reactions. Identification of mast cells as a progeny of a bone marrow hematopoietic stem cell in 1977 led us to successful in vitro culture of human mast cells. Along with the development of molecular biological techniques, the structure of the high affinity IgE receptor (FceRI was determined in 1989. These findings and subsequent investigations brought deeper understanding of IgE-mediated allergic diseases in the past half century, especially where mast cells are involved. We have now even obtained the information about whole genome expression of FceRI-dependently activated mast cells. In sharp contrast to our comprehension of allergic diseases where IgE and mast cells are involved, the mechanisms involved in non-IgE-mediated allergic diseases or non-IgE-mediated phase of IgE-mediated diseases are almost left unsolved and are waiting for devoted investigators to reveal it.

  1. 2010 Mississippi Curriculum Framework: Postsecondary Banking and Finance Technology. (Program CIP: 52.0803 - Banking and Financial Support Services)

    Science.gov (United States)

    Gullett, Janet; Dinkins, Shivochie

    2010-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  2. Comparative Analysis of Teacher Trainee Students' eLearning Technology (ELT) Readiness towards Promoting Global Curriculum Best Practice

    Science.gov (United States)

    Ogwu, Edna N.

    2016-01-01

    This study compares teacher trainee students (TTSs), electronic learning technology (ELT) readiness, competence as well as their constraints to ELT readiness using 373 University education students' from Botswana and Nigeria that are randomly selected. Data was descriptively analysed based on the research objectives and hypotheses using mean…

  3. Using Information Communication Technologies to Develop Dynamic Curriculum Frameworks for Diverse Cohorts: A Case Study from Event Management

    Science.gov (United States)

    Hadley, Bree Jamila

    2012-01-01

    This article investigates the role of information communication technologies (ICTs) in establishing a well-aligned, authentic learning environment for a diverse cohort of non-cognate and cognate students studying event management in a higher education context. Based on a case study which examined the way ICTs assisted in accommodating diverse…

  4. Social Studies: Application Units. Course II, Teachers. Computer-Oriented Curriculum. REACT (Relevant Educational Applications of Computer Technology).

    Science.gov (United States)

    Tecnica Education Corp., San Carlos, CA.

    This book is one of a series in Course II of the Relevant Educational Applications of Computer Technology (REACT) Project. It is designed to point out to teachers two of the major applications of computers in the social sciences: simulation and data analysis. The first section contains a variety of simulation units organized under the following…

  5. 2011 Mississippi Curriculum Framework: Postsecondary Dental Assisting Technology. (Program CIP: 51.0601 - Dental Assisting/Assistant)

    Science.gov (United States)

    Addison, Emily; Bokros, Christy; Gavant, H. Richard; Johnson, Robin

    2011-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  6. Curriculum Development for Technology-Based Entrepreneurship Education: A Cross-Disciplinary and Cross-Cultural Approach

    Science.gov (United States)

    Kazakeviciute, Agne; Urbone, Renata; Petraite, Monika

    2016-01-01

    University-based entrepreneurship education is facing a paradigm shift between the classical "business school" and the contemporary cross-disciplinary "technology venturing" approach, mainly advocated by engineering schools and other communities outside business schools. The conflict is between structured "business…

  7. 2010 Mississippi Curriculum Framework: Postsecondary Meat Merchandising Technology. (Program CIP: 12.0506 - Meat Cutting/Meat Cutter)

    Science.gov (United States)

    Jones, Roger; Currie, Lamar; Clayton, Sheila

    2010-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  8. 2008 Mississippi Curriculum Framework: Postsecondary Food Production and Management Technology. (Program CIP: 12.0508 - Institutional Food Workers)

    Science.gov (United States)

    Carver, Matthew; Hoff, Jody; Little, Lisa; Samuel, Carolyn

    2008-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  9. 2008 Mississippi Curriculum Framework: Postsecondary Irrigation Management Technology. (Program CIP:01.0699 - Applied Horticulture/Horticultural Business Services, Other)

    Science.gov (United States)

    Oliver, Michael L.

    2008-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  10. 2009 Mississippi Curriculum Framework: Postsecondary Funeral Service Technology. (Program CIP-12.0301 - Funeral Service and Mortuary Science)

    Science.gov (United States)

    Anderson, Larry; Dickerson, Octavia; Harvey, Bill; Moore, Tony

    2009-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  11. 2005 Mississippi Curriculum Framework: Postsecondary Banking and Finance Technology. (Program CIP: 52.0803 - Banking and Financial Support Services)

    Science.gov (United States)

    Gullett, Janet; Thigpen, Herbert

    2005-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  12. Using Information Communication Technologies to Develop Dynamic Curriculum Frameworks for Diverse Cohorts: A Case Study from Event Management

    Science.gov (United States)

    Hadley, Bree Jamila

    2012-01-01

    This article investigates the role of information communication technologies (ICTs) in establishing a well-aligned, authentic learning environment for a diverse cohort of non-cognate and cognate students studying event management in a higher education context. Based on a case study which examined the way ICTs assisted in accommodating diverse…

  13. Curriculum Development for Technology-Based Entrepreneurship Education: A Cross-Disciplinary and Cross-Cultural Approach

    Science.gov (United States)

    Kazakeviciute, Agne; Urbone, Renata; Petraite, Monika

    2016-01-01

    University-based entrepreneurship education is facing a paradigm shift between the classical "business school" and the contemporary cross-disciplinary "technology venturing" approach, mainly advocated by engineering schools and other communities outside business schools. The conflict is between structured "business…

  14. Science and Technology Educators' Enacted Curriculum: Areas of Possible Collaboration for an Integrative STEM Approach in Public Schools

    Science.gov (United States)

    Brown, Josh; Brown, Ryan; Merrill, Chris

    2012-01-01

    Science, Technology, Engineering, and Mathematics (STEM) teachers teach multiple concepts that lend themselves to possible collaboration on a daily basis. Much like Metz's (2009) insightful discussion about the importance of science educators creating partnerships in the community "outside the school walls," integrative STEM teaching also requires…

  15. Infusion of Emerging Technologies and New Teaching Methods into the Mechanical Engineering Curriculum at the City College of New York

    Science.gov (United States)

    Delale, Feridun; Liaw, Benjamin M.; Jiji, Latif M.; Voiculescu, Ioana; Yu, Honghui

    2011-01-01

    From October 2003 to April 2008 a systemic reform of the Mechanical Engineering program at The City College of New York was undertaken with the goal of incorporating emerging technologies (such as nanotechnology, biotechnology, Micro-Electro-Mechanical Systems (MEMS), intelligent systems) and new teaching methodologies (such as project based…

  16. 2007 Mississippi Curriculum Framework: Postsecondary Meat Merchandising Technology (Program CIP: 12.0506 - Meat Cutting/Meat Cutter)

    Science.gov (United States)

    Jones, Roger; Currie, Lamar; Clayton, Sheila

    2007-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  17. 2010 Mississippi Curriculum Framework: Postsecondary Emergency Medical Technician. (Program CIP: 51.0904 - Emergency Medical Technology/Technician)

    Science.gov (United States)

    Briscoe, Lisa; Bryant, Katrina; Galtelli, Mark; Glasson, Kristi; Hall, David; Hood, Brenda; Mahaffey, Libby; McBryde, John; Read, John; Shirley, Gary; Wright, Al

    2010-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  18. Technology and Curriculum Standards: How Well Do Internet-Based Learning Games Support Common Core Standards for Mathematics?

    Science.gov (United States)

    Bingham, Teri; Ray, Jan

    2013-01-01

    In an effort to keep up with the new generation of digital learners, educators are integrating multiple forms of technology into their teaching, including online learning game applications. The purpose of this study was to determine the degree to which internet-based learning game applications selected by preservice teachers were aligned with the…

  19. Mast cell density in cardio-esophageal mucosa.

    Directory of Open Access Journals (Sweden)

    Fatemeh E Mahjoub

    2014-12-01

    Full Text Available Mast cells are related to certain gastrointestinal complaints. Mast cell density has not been studied in cardio-esophageal region to the best of our knowledge. In this study we wanted to obtain an estimate of mast cell density in this region and compare it with mast cell density in antrum. From April 2007 till March 2010, we chose children (<14 years old who underwent upper endoscopy and from whom the taken biopsy was stated to be from lower third of esophagus, but in microscopic examination either cardio- esophageal mucosa or only cardiac mucosa was seen. Mast cells were counted by Giemsa stain at × 1000 magnification in 10 fields. 71 children (<14 years old were included in this study of which, 63.4% (n=45 were female and 36.6% (n=26 were male. The mean age of patients was 7.20 ± 4.21 years (range: 0.2 -14 years. The most common clinical manifestations were recurrent abdominal pain (64.8% and vomiting (23.9% followed by symptoms of gastro-esophageal reflux disorder, poor weight gain, hematemesis and dysphagia. The mean mast cell density in the cardiac mucosa was 33.41 ± 32.75 in 0.25 mm2 (range: 0-155, which was two times of that in antral mucosa. We found a significant but weak positive correlation at the 0.05 level between mast cell density of cardiac mucosa and the antrum. Higher mast cell counts were seen in cardiac mucosa in this study. Significant positive correlation between mast cell density of cardiac mucosa and the antrum could hint to a single underlying etiology for the inflammatory process in gastro- esophageal junction and gastric mucosa.

  20. Martian environmental simulation for a deployable lattice mast

    Science.gov (United States)

    Warden, Robert M.

    1994-01-01

    The Mars Pathfinder mission (formerly Mars Environmental Survey or MESUR) is scheduled for launch in December 1996 and is designed to place a small lander on the surface of Mars. After impact, the lander unfolds to expose its solar panels and release a miniature rover. Also on board is the Imager for Mars Pathfinder (IMP) binocular camera which is elevated by a deployable mast to obtain a panoramic view of the landing area. The design of this deployable mast is based on similar designs which have a long and successful flight history. In the past when this type of self-deployable mast has been used, a rate limiter has been incorporated to control the speed of deployment. In this application, to reduce weight and complexity, it was proposed to eliminate the rate limiter so that the mast would deploy without restraint. Preliminary tests showed that this type of deployment was possible especially if the deployed length was relatively short, as in this application. Compounding the problem, however, was the requirement to deploy the mast at an angle of up to 30 degrees from vertical. The deployment process was difficult to completely analyze due to the effects of gravitational and inertial loads on the mast and camera during rapid extension. Testing in a realistic manner was imperative to verify the system performance. A deployment test was therefore performed to determine the maximum tilt angle at which the mast could reliably extend and support the camera on Mars. The testing of the deployable mast requires partial gravity compensation to simulate the smaller force of Martian gravity. During the test, mass properties were maintained while weight properties were reduced. This paper describes the testing of a deployable mast in a simulated Martian environment as well as the results of the tests.

  1. Quantification and Localization of Mast Cells in Periapical Lesions

    Science.gov (United States)

    Mahita, VN; Manjunatha, BS; Shah, R; Astekar, M; Purohit, S; Kovvuru, S

    2015-01-01

    Background: Periapical lesions occur in response to chronic irritation in periapical tissue, generally resulting from an infected root canal. Specific etiological agents of induction, participating cell population and growth factors associated with maintenance and resolution of periapical lesions are incompletely understood. Among the cells found in periapical lesions, mast cells have been implicated in the inflammatory mechanism. Aim: Quantifications and the possible role played by mast cells in the periapical granuloma and radicular cyst. Hence, this study is to emphasize the presence (localization) and quantification of mast cells in periapical granuloma and radicular cyst. Materials and Methods: A total of 30 cases and out of which 15 of periapical granuloma and 15 radicular cyst, each along with the case details from the previously diagnosed cases in the department of oral pathology were selected for the study. The gender distribution showed male 8 (53.3%) and females 7 (46.7%) in periapical granuloma cases and male 10 (66.7%) and females 5 (33.3%) in radicular cyst cases. The statistical analysis used was unpaired t-test. Results: Mean mast cell count in periapical granuloma subepithelial and deeper connective tissue, was 12.40 (0.99%) and 7.13 (0.83%), respectively. The mean mast cell counts in subepithelial and deeper connective tissue of radicular cyst were 17.64 (1.59%) and 12.06 (1.33%) respectively, which was statistically significant. No statistical significant difference was noted among males and females. Conclusion: Mast cells were more in number in radicular cyst. Based on the concept that mast cells play a critical role in the induction of inflammation, it is logical to use therapeutic agents to alter mast cell function and secretion, to thwart inflammation at its earliest phases. These findings may suggest the possible role of mast cells in the pathogenesis of periapical lesions. PMID:25861530

  2. Mast cells and gastrointestinal dysmotility in the cystic fibrosis mouse.

    Directory of Open Access Journals (Sweden)

    Robert C De Lisle

    Full Text Available BACKGROUND: Cystic fibrosis (CF has many effects on the gastrointestinal tract and a common problem in this disease is poor nutrition. In the CF mouse there is an innate immune response with a large influx of mast cells into the muscularis externa of the small intestine and gastrointestinal dysmotility. The aim of this study was to evaluate the potential role of mast cells in gastrointestinal dysmotility using the CF mouse (Cftr(tm1UNC, Cftr knockout. METHODOLOGY: Wild type (WT and CF mice were treated for 3 weeks with mast cell stabilizing drugs (ketotifen, cromolyn, doxantrazole or were treated acutely with a mast cell activator (compound 48/80. Gastrointestinal transit was measured using gavage of a fluorescent tracer. RESULTS: In CF mice gastric emptying at 20 min post-gavage did not differ from WT, but was significantly less than in WT at 90 min post-gavage. Gastric emptying was significantly increased in WT mice by doxantrazole, but none of the mast cell stabilizers had any significant effect on gastric emptying in CF mice. Mast cell activation significantly enhanced gastric emptying in WT mice but not in CF mice. Small intestinal transit was significantly less in CF mice as compared to WT. Of the mast cell stabilizers, only doxantrazole significantly affected small intestinal transit in WT mice and none had any effect in CF mice. Mast cell activation resulted in a small but significant increase in small intestinal transit in CF mice but not WT mice. CONCLUSIONS: The results indicate that mast cells are not involved in gastrointestinal dysmotility but their activation can stimulate small intestinal transit in cystic fibrosis.

  3. Mast Cell Activation Syndrome: Proposed Diagnostic Criteria: Towards a global classification for mast cell disorders

    OpenAIRE

    2010-01-01

    The term “mast cell activation syndrome (MCAS)” is finding increasing use as a diagnosis for individuals who present with signs and symptoms involving the dermis, gastrointestinal track and cardiovascular system; frequently accompanied by neurologic complaints. Such patients often have undergone multiple extensive medical evaluations by different physicians in varied disciplines without a definitive medical diagnosis until the diagnosis of “MCAS” is applied. However, “MCAS” as a distinct clin...

  4. Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States

    OpenAIRE

    Sachiko Chikahisa; Tohru Kodama; Atsushi Soya; Yohei Sagawa; Yuji Ishimaru; Hiroyoshi Séi; Seiji Nishino

    2013-01-01

    Mast cell activation and degranulation can result in the release of various chemical mediators, such as histamine and cytokines, which significantly affect sleep. Mast cells also exist in the central nervous system (CNS). Since up to 50% of histamine contents in the brain are from brain mast cells, mediators from brain mast cells may significantly influence sleep and other behaviors. In this study, we examined potential involvement of brain mast cells in sleep/wake regulations, focusing espec...

  5. Learning science, talking science: The impact of a technology-enhanced curriculum on students' science learning in linguistically diverse mainstream classrooms

    Science.gov (United States)

    Ryoo, Kihyun

    This study explored effective instructional approaches that can help ELLs master both the content and the language of science and possibly close the achievement gaps between ELLs and EPSs. The study specifically examined the impact of a technology-enhanced curriculum that consisted of two teaching approaches to ELLs' science learning: teaching science in everyday English (the Everyday Language approach) and using computer simulation to solve scientific problems (the Simulation approach). For this study, the technology-enhanced curriculum was carefully constructed based on the actual curriculum design, five design-based research studies, and consultation with fifth-grade teachers. The randomized experimental study was conducted with 220 fifth-grade ELLs and EPSs from four public elementary schools. Before the study began, all students took pretests and three students randomly selected from each class took pre-interviews. All students participated in six one-hour long consecutive science sessions about the concepts of photosynthesis and respiration. For the first three sessions, students received individual science instruction about the scientific concepts using a computer program. Students in the Everyday-Language condition (the Everyday-Simulation and the Everyday-Website groups) were taught in everyday language prior to the introduction of scientific language. By contrast, students in the Hybrid-Language condition (the Hybrid-Simulation and the Hybrid-Website groups) were taught simultaneously in both everyday language and scientific language (hybrid language). For the last three sessions, students were randomly assigned to triads stratified by gender and English proficiency, and each triad participated in a series of problem-solving activities. Students in the Simulation condition (the Everyday-Simulation and the Hybrid-Simulation groups) used a computer simulation program, whereas students in the Website condition (the Everyday-Website and the Hybrid

  6. Dual view FIDA measurements on MAST

    CERN Document Server

    Michael, C A; Crowley, B; Jones, O; Heidbrink, W W; Pinches, S; Braeken, E; Akers, R; Challis, C; Turnyanskiy, M; Patel, A; Muir, D; Gaffka, R; Bailey, S

    2013-01-01

    A Fast Ion Deuterium Alpha (FIDA) spectrometer was installed on MAST to measure radially resolved information about the fast ion density and its distribution in energy and pitch angle. Toroidally and vertically-directed collection lenses are employed, to detect both passing and trapped particle dynamics, and reference views are installed to subtract the background. This background is found to contain a substantial amount of passive FIDA emission driven by edge neutrals, and to depend delicately on viewing geometry. Results are compared with theoretical expectations based on the codes NUBEAM (for fast ion distributions) and FIDASIM. Calibrating via the measured beam emission peaks, the toroidal FIDA signal profile agrees with classical simulations in MHD quiescent discharges where the neutron rate is also classical. Long-lived modes (LLM) and chirping modes decrease the core FIDA signal significantly, and the profile can be matched closely to simulations using anomalous diffusive transport; a spatially uniform...

  7. Immunohistochemical characterization of feline mast cell tumors.

    Science.gov (United States)

    Mallett, C L; Northrup, N C; Saba, C F; Rodriguez, C O; Rassnick, K M; Gieger, T L; Childress, M O; Howerth, E W

    2013-01-01

    Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.

  8. Mini-mast CSI testbed user's guide

    Science.gov (United States)

    Tanner, Sharon E.; Pappa, Richard S.; Sulla, Jeffrey L.; Elliott, Kenny B.; Miserentino, Robert; Bailey, James P.; Cooper, Paul A.; Williams, Boyd L., Jr.; Bruner, Anne M.

    1992-01-01

    The Mini-Mast testbed is a 20 m generic truss highly representative of future deployable trusses for space applications. It is fully instrumented for system identification and active vibrations control experiments and is used as a ground testbed at NASA-Langley. The facility has actuators and feedback sensors linked via fiber optic cables to the Advanced Real Time Simulation (ARTS) system, where user defined control laws are incorporated into generic controls software. The object of the facility is to conduct comprehensive active vibration control experiments on a dynamically realistic large space structure. A primary goal is to understand the practical effects of simplifying theoretical assumptions. This User's Guide describes the hardware and its primary components, the dynamic characteristics of the test article, the control law implementation process, and the necessary safeguards employed to protect the test article. Suggestions for a strawman controls experiment are also included.

  9. Mast Cell and Immune Inhibitory Receptors

    Institute of Scientific and Technical Information of China (English)

    LixinLi; ZhengbinYao

    2004-01-01

    Modulation by balancing activating and inhibitory receptors constitutes an important mechanism for regulating immune responses. Cells that are activated following ligation of receptors bearing immunoreceptor tyrosine-based activation motifs (ITAMs) can be negatively regulated by other receptors bearing immunoreceptor tyrosine-based inhibition motifs (ITIMs). Human mast cells (MCs) are the major effector cells of type I hypersensitivity and important participants in a number of disease processes. Antigen-mediated aggregation of IgE bound to its high-affinity receptor on MCs initiates a complex series of biochemical events leading to MC activation. With great detailed description and analysis of several inhibitory receptors on human MCs, a central paradigm of negative regulation of human MC activation by these receptors has emerged. Cellular & Molecular Immunology. 2004;1(6):408-415.

  10. Effect of fexofenadine,a mast cell blocker,in infertile men with significantly increased testicular mast cells

    Institute of Scientific and Technical Information of China (English)

    CayaS; ApaDD

    2002-01-01

    Aim:To investigate the role of fexofenadine,a mast cell blocker,on semen quality in the treatment of infertile men.Methods:The study included 16 Turkish idiopathic infertile men with azoospermia or oligozoospermia who underwent testicular biopsy to examine maxt cells containing tryptase.In all patients,a complete metical history,clinical examination,semen analysis and serum hormone assay were carried out.The biopsy specimens were immunohistochemically stained with antihuman tryptase for mast cells.The number of total mast cells per seminiferous tubule was calculated and recorded as mast cell index.The patients were divided into two groups according to their mast cell index:the higher (≥1,n=9) and the lower (<1,n=7) index groups.Fexofenadine was administered orally at a dose of 180mg/day for 4 to 9 months.Pre-and post-treatment semen parameters,including total motile sperm counts(TMC) were recorded and compared.spontaneous pregnancies after the treatment were registered.Results:There was no statistically significant difference in TMC between the pre-treatment and post-treatment values in patients with higher and lower mast cell index(P≥0.05).In both groups,nobody had a significant response to the treatment and there was no spontaneous pregnancy after the treatment.Conclusion:Althought testicular dysfunction is closely associated with increased number of testicular mast cells,fexofenadine,a mast cell blocker,appears not having any benefit in the treatment of Turkish infertile men with a significant increase in testicular mast cells.

  11. 2010 Mississippi Curriculum Framework: Postsecondary Veterinary Technology. (Program CIP: 51.0808 - Veterinary/Animal Health Technology/Technician and Veterinary Assistant)

    Science.gov (United States)

    Glenn, Bobby; Sills, Kirby

    2010-01-01

    As the world economy continues to evolve, businesses and industries must adopt new practices and processes in order to survive. Quality and cost control, work teams and participatory management, and an infusion of technology are transforming the way people work and do business. Employees are now expected to read, write, and communicate…

  12. THE EVALUATION OF OBJECTIVES AND ACTIVITIES IN THE PRIMARY EDUCATION 5TH GRADE SCIENCE AND TECHNOLOGY CURRICULUM IN TERMS OF MULTIPLE INTELLIGENCE THEORY

    Directory of Open Access Journals (Sweden)

    Oğuz GÜRBÜZTÜRK

    2013-06-01

    Full Text Available The purpose of this study is to know the teachers’ opinions in terms of multiple intelligence theory about the objectives and activities in the units of “Earth, Sun and Moon” and the “Electricity in Our Life” in the primary education 5th grade science and technology curriculum. The survey model was used in this study. The population of this study consists of 262 5th grade teachers working in the center of Malatya. The sample consists of 190 5th grade teachers who were selected randomly. Questionnaire was used to collect data that are consisted of 70 items. Teachers are asked to select one dominant intelligence type for 65 objectives and activities. To analyze the data, the background information of teachers like seniority, graduated faculty, whether or not they had in-service education were compared to teachers opinions about which intelligence area is suitable with these objectives and activities and these comparison information was given and commented with frequencies, percentages and cross tabs. Given the results of this study, about evaluating the objectives and activities in these units, taking all activities in the teaching-learning process into consideration, it is discovered that, teachers generally focus on visual, spatial, logical and mathematical intelligence areas and they think in the same way regardless of their seniority, graduated faculty, and whether or not they had in-service education about teaching-learning theories and models. Some advices are given based on the results of this study.

  13. Mast cells in allergy and autoimmunity: implications for adaptive immunity.

    Science.gov (United States)

    Gregory, Gregory D; Brown, Melissa A

    2006-01-01

    As in the fashion industry, trends in a particular area of scientific investigation often are fleeting but then return with renewed and enthusiastic interest. Studies of mast cell biology are good examples of this. Although dogma once relegated mast cells almost exclusively to roles in pathological inflammation associated with allergic disease, these cells are emerging as important players in a number of other physiological processes. Consequently, they are quickly becoming the newest "trendy" cell, both within and outside the field of immunology. As sources of a large array of pro- and anti-inflammatory mediators, mast cells also express cell surface molecules with defined functions in lymphocyte activation and trafficking. Here, we provide an overview of the traditional and newly appreciated contributions of mast cells to both innate and adaptive immune responses.

  14. Gene expression profiles in adenosine-treated human mast cells

    African Journals Online (AJOL)

    ajl yemi

    2011-10-26

    Oct 26, 2011 ... 11Department of Biotechnology and School of Biotechnology, Yeungnam ... The role of mast cells in allergic diseases and innate immunity has been widely .... the sequence quality and cloning vector sequences were.

  15. 基于P/T数字转台的计算机控制课程设计%Curriculum design of computer control technology based on P/T digital indexing table

    Institute of Scientific and Technical Information of China (English)

    许谨; 席剑辉; 齐胜男

    2012-01-01

    为了配合计算机控制技术课程的教学,加强学生对计算机控制技术的认识,开设了相关的课程设计.利用固高公司的产品—P/T数字转台实验系统为平台,开设相关的课程设计,要求学生以C++或其他高级语言为开发工具,根据学生的个体差异,提出不同的课程设计要求.通过课程设计,使学生进一步了解计算机控制技术的理论知识,并提高独立分析、解决问题和程序设计的能力.%To coordinate with the computer control technology curriculum, the related curriculum design is set up. Googol Technology Limited production of P/T digital indexing table is chosen for development platform, C + + or other senior language is chosen for development tools. According to the student' s individual differences, different course design requirements are put forward. This curriculum design can help students to further understand the theoretic knowledge of the computer control technology and improve their abilities of programming and problem-solving.

  16. Reform and Practice of Automotive Technology Curriculum%高职汽车运用技术专业建设的改革与实践

    Institute of Scientific and Technical Information of China (English)

    曹登华

    2015-01-01

    湖北交通职业技术学院汽车运用技术专业以提高人才培养质量为核心,坚持校企合作、工学结合的职业教育理念,不断进行专业建设改革与实践,大力实施订单培养,为校企合作提供平台,开拓专业建设思路;构建“公共平台+岗位平台+企业特色平台”的柔性课程体系;改革专业教学组织结构,使之与工学结合课程体系的实施相适应;适应汽车后市场主体变化,进行汽车品牌实训室建设,进行三阶段实训教学;围绕岗位知识能力素质要求,构建专业竞赛体系;引进企业文化和管理理念,推行5S管理,提升学生职业素质等,有力促进了专业的发展。%The paper first introduces the practice of Hubei Communications Technical College. Their automotive technology curriculum aims at improving students’quality. First, they cooperate with enterprises, offering apprentice-ship program and training students according to the “order”from enterprises; second, they keep innovating curricula, creating a flexible management platform,“public platform +position platform + enterprises”, for the cooperative curricu-la; third, the courses construction are also reformed to fit in the cooperative curriculum system; fourth, to adjust to the change of subjects in Auto after-service market, the college has built a branded Auto Training Laboratory especially for the so called “Three Stage Training”; fifth, it has established a skills competition system testing the knowledge and skills required by some specific position;finally, company culture and management principle of some famous enterprises are introduced in class and 5s management system is implemented to enhance students’professional quality.

  17. Pathogenic role of mast cells in experimental eosinophilic esophagitis

    OpenAIRE

    Niranjan, Rituraj; Mavi, Parm; Rayapudi, Madhavi; Dynda, Scott; Mishra, Anil

    2013-01-01

    Eosinophilic esophagitis (EoE) is a chronic allergic disease characterized by esophageal intraepithelial eosinophils, extracellular eosinophil granule deposition, induced mast cell accumulation, and epithelial cell hyperplasia. However, the processes involved in the development of a number of these characteristics are largely unknown. Herein, we tested the hypothesis whether induced mast cell accumulation in the esophagus has a role in promoting EoE pathogenesis. Accordingly, we induced exper...

  18. Irritable bowel syndrome - An inflammatory disease involving mast cells

    OpenAIRE

    Philpott, Hamish; Gibson, Peter; Thien, Frank

    2011-01-01

    Irritable bowel syndrome (IBS) is traditionally defined as a functional disorder - that is the presence of symptoms in the absence of demonstrable pathological abnormalities. In recent times, low grade inflammatory infiltrates in both the small and large bowel of some patients with IBS - often rich in mast cells, along with serological markers of low grade inflammation have focussed attention on IBS as an inflammatory disease. The observation that mast cells often lie in close association to ...

  19. 基于项目管理技术的职业生涯规划课程设计教学探索%Teaching Exploration of Curriculum Design for Career Planning Based on Project Management Technology

    Institute of Scientific and Technical Information of China (English)

    杨泽琳; 周庆强; 郭经宝

    2015-01-01

    The popularization of career planning curriculum has strategic significance for college students scientific and effective employment. From the perspective of career planning curriculum design, it is analyzed the problems in the curriculum design of career planning, and the overall conception of the curriculum design of the career planning was proposed based on the project management technology. Meanwhile, the program of the course design was described in detail in order to lay the foundation for improving the college students' career planning and employment guidance mechanism.%职业生涯规划课程的普及对大学生科学、有效地就业具有战略意义.本文从职业生涯规划课程设计的角度入手,分析了职业生涯规划课程设计中存在的问题,提出了基于项目管理技术的职业生涯规划课程设计的总体构想,并详细描述了课程设计的方案,以期为完善大学生职业生涯规划与就业指导机制奠定基础.

  20. Mast cells, peptides and cardioprotection - an unlikely marriage?

    LENUS (Irish Health Repository)

    Walsh, S K

    2012-01-31

    1 Mast cells have classically been regarded as the \\'bad guys\\' in the setting of acute myocardial ischaemia, where their released contents are believed to contribute both to tissue injury and electrical disturbances resulting from ischaemia. Recent evidence suggests, however, that if mast cell degranulation occurs in advance of ischaemia onset, this may be cardioprotective by virtue of the depletion of mast cell contents that can no longer act as instruments of injury when the tissue becomes ischaemic. 2 Many peptides, such as ET-1, adrenomedullin, relaxin and atrial natriuretic peptide, have been demonstrated to be cardioprotective when given prior to the onset of myocardial ischaemia, although their physiological functions are varied and the mechanisms of their cardioprotective actions appear to be diverse and often ill defined. However, one common denominator that is emerging is the ability of these peptides to modulate mast cell degranulation, raising the possibility that peptide-induced mast cell degranulation or stabilization may hold the key to a common mechanism of their cardioprotection. 3 The aim of this review was to consolidate the evidence implying that mast cell degranulation could play both a detrimental and protective role in myocardial ischaemia, depending upon when it occurs, and that this may underlie the cardioprotective effects of a range of diverse peptides that exerts physiological effects within the cardiovascular system.

  1. The Mast Cell, Contact, and Coagulation System Connection in Anaphylaxis

    Directory of Open Access Journals (Sweden)

    Mar Guilarte

    2017-07-01

    Full Text Available Anaphylaxis is the most severe form of allergic reaction, resulting from the effect of mediators and chemotactic substances released by activated cells. Mast cells and basophils are considered key players in IgE-mediated human anaphylaxis. Beyond IgE-mediated activation of mast cells/basophils, further mechanisms are involved in the occurrence of anaphylaxis. New insights into the potential relevance of pathways other than mast cell and basophil degranulation have been unraveled, such as the activation of the contact and the coagulation systems. Mast cell heparin released upon activation provides negatively charged surfaces for factor XII (FXII binding and auto-activation. Activated FXII, the initiating serine protease in both the contact and the intrinsic coagulation system, activates factor XI and prekallikrein, respectively. FXII-mediated bradykinin (BK formation has been proven in the human plasma of anaphylactic patients as well as in experimental models of anaphylaxis. Moreover, the severity of anaphylaxis is correlated with the increase in plasma heparin, BK formation and the intensity of contact system activation. FXII also activates plasminogen in the fibrinolysis system. Mast cell tryptase has been shown to participate in fibrinolysis through plasmin activation and by facilitating the degradation of fibrinogen. Some usual clinical manifestations in anaphylaxis, such as angioedema or hypotension, or other less common, such as metrorrhagia, may be explained by the direct effect of the activation of the coagulation and contact system driven by mast cell mediators.

  2. The role of mast cells in vascularized recurrent pterygium

    Directory of Open Access Journals (Sweden)

    Ali Riza Cenk Celebi

    2014-10-01

    Full Text Available Objective: To determine and compare the mast cell count in primary and recurrent vascularized pterygium, and in normal bulbar conjunctiva. Methods: The study included 22 patients with primary pterygium (PP group and 28 patients with vascularized recurrent pterygium (VRP group that underwent excision via the limbal conjunctival autograft technique. Normal conjunctiva samples were collected from the superotemporal bulbar conjunctival region, just temporal to the site from which the autograft conjunctival tissue was harvested. The total number of mast cells in the pterygium (primary and recurrent and control tissue samples was calculated microscopically using 1% toluidine blue stain under 400× magnification. Results: The mean mast cell count in primary and vascularized recurrent pterygium tissue was 7.45 ± 2.06 mm–2 and 16.11 ± 4.33 mm–2, respectively, and the difference was significant (independent samples t-test, P<0.001. The mean mast cell count in pterygium tissue was significantly higher than that in normal conjunctiva tissue in both groups (Student's t-test, P<0.001. Conclusion: An increase in the number of mast cells might play a role in the pathogenesis of recurrent pterygium. Determination of a mast cell count cut-off value could be of diagnostic significance for recurrent pterygium.

  3. Mast cells and basophils in cutaneous immune responses.

    Science.gov (United States)

    Otsuka, A; Kabashima, K

    2015-02-01

    Mast cells and basophils share some functions in common and are generally associated with T helper 2 (Th2) immune responses, but taking basophils as surrogate cells for mast cell research or vice versa for several decades is problematic. Thus far, their in vitro functions have been well studied, but their in vivo functions remained poorly understood. New research tools for their functional analysis in vivo have revealed previously unrecognized roles for mast cells and basophils in several skin disorders. Newly developed mast cell-deficient mice provided evidence that mast cells initiate contact hypersensitivity via activating dendritic cells. In addition, studies using basophil-deficient mice have revealed that basophils were responsible for cutaneous Th2 skewing to haptens and peptide antigens but not to protein antigens. Moreover, human basophils infiltrate different skin lesions and have been implicated in the pathogenesis of skin diseases ranging from atopic dermatitis to autoimmune diseases. In this review, we will discuss the recent advances related to mast cells and basophils in human and murine cutaneous immune responses.

  4. Irritable bowel syndrome - An inflammatory disease involving mast cells.

    Science.gov (United States)

    Philpott, Hamish; Gibson, Peter; Thien, Frank

    2011-04-01

    Irritable bowel syndrome (IBS) is traditionally defined as a functional disorder - that is the presence of symptoms in the absence of demonstrable pathological abnormalities. In recent times, low grade inflammatory infiltrates in both the small and large bowel of some patients with IBS - often rich in mast cells, along with serological markers of low grade inflammation have focussed attention on IBS as an inflammatory disease. The observation that mast cells often lie in close association to enteric neurons, and in-vitro and in-vivo animal studies demonstrating that mast cell mediators may influence enteric motility provides a biologically plausible causal mechanism in IBS. Pilot studies on patients with IBS using the mast cell stabiliser sodium cromoglycate ('proof of concept') have been encouraging. The essential question remains why mast cells infiltrate the bowel of IBS patients. A disturbance of the 'brain-gut axis' is the current favoured hypothesis, whereby childhood stress or psychiatric comorbidity act via neuro-immune mechanisms to modulate low grade inflammation. An alternative hypothesis is that food allergy may be responsible. Serum specific IgE, and skin prick tests are not elevated in IBS patients, suggesting type 1 IgE mediated food allergy is not the cause. However questionnaire based studies indicate IBS patients have higher rates of atopic disease, and increased bronchial reactivity to methacholine has been demonstrated. In this review, we highlight the potential role of mast cells in IBS, and current and future research directions into this intriguing condition.

  5. Structural analysis of guyed mast exposed to wind action

    Directory of Open Access Journals (Sweden)

    Pezo Milada L.

    2016-01-01

    Full Text Available The behavior of the mast is non-linear due to its slenderness and compliant guy-support system, having a tendency to lose stability and even crush suddenly. Wind load is one of the main factors affecting the stability of the structure of the mast. Structural assessment of the different mast configurations has been investigated in the past. Furthermore, European standards EN 1993-3-1:2006 and EN 1993-1-6:2007 already provides some guidelines about the basis of structural analysis of masts and towers. This paper presents the results of numerical simulations of a guyed mast exposed to wind action using finite element method. Structural analyses were performed for three different constant wind loads, modal analysis provides the values of natural frequency and mode shapes, while the stability analysis was performed for the first three buckling load factor values. The motivation for this study is to investigate the contribution of finite element method to structural analysis of a lattice structure such as guyed mast as an alternative and/or improvement to the literature and codes. [Projekat Ministarstva nauke Republike Srbije, br. TR33036

  6. Mast cell-derived histamine mediates cystitis pain.

    Directory of Open Access Journals (Sweden)

    Charles N Rudick

    Full Text Available BACKGROUND: Mast cells trigger inflammation that is associated with local pain, but the mechanisms mediating pain are unclear. Interstitial cystitis (IC is a bladder disease that causes debilitating pelvic pain of unknown origin and without consistent inflammation, but IC symptoms correlate with elevated bladder lamina propria mast cell counts. We hypothesized that mast cells mediate pelvic pain directly and examined pain behavior using a murine model that recapitulates key aspects of IC. METHODS AND FINDINGS: Infection of mice with pseudorabies virus (PRV induces a neurogenic cystitis associated with lamina propria mast cell accumulation dependent upon tumor necrosis factor alpha (TNF, TNF-mediated bladder barrier dysfunction, and pelvic pain behavior, but the molecular basis for pelvic pain is unknown. In this study, both PRV-induced pelvic pain and bladder pathophysiology were abrogated in mast cell-deficient mice but were restored by reconstitution with wild type bone marrow. Pelvic pain developed normally in TNF- and TNF receptor-deficient mice, while bladder pathophysiology was abrogated. Conversely, genetic or pharmacologic disruption of histamine receptor H1R or H2R attenuated pelvic pain without altering pathophysiology. CONCLUSIONS: These data demonstrate that mast cells promote cystitis pain and bladder pathophysiology through the separable actions of histamine and TNF, respectively. Therefore, pain is independent of pathology and inflammation, and histamine receptors represent direct therapeutic targets for pain in IC and other chronic pain conditions.

  7. Practical Research on the Teaching Reform of Technology Economics Curriculum%技术经济学课程教学改革实践研究

    Institute of Scientific and Technical Information of China (English)

    樊瑜; 赵世强; 张宏; 张丽

    2014-01-01

    技术经济学是一门技术和经济相交叉的边缘学科,具有很强的实践性。该课程的学习对学生加强经济管理知识,完善知识结构,提高综合素质,树立市场观念,都具有重要意义。长期以来,技术经济学课程传统的教学方式与单一的考试模式,易导致学生缺乏学习积极性,不利于学生自主学习能力和创新能力的培养。根据创新人才培养要求,通过北京建筑大学技术经济学课程教学改革实践,对技术经济学从教学内容、教学方式及考核方式等方面进行改革,总结出“讲授+案例+实践”三位一体的教学模式,新的教学模式以培养学生创新意识和实践能力为目标,大大提高学生理论联系实际的能力,锻炼学生解决实际问题的能力,开发学生学习的主动性和创新思维,并改变原有的单一考核方式为全过程、多角度评价,对于提高技术经济学课程教学效果具有积极的作用。%Technical economics is an interdisciplinary science between technology and economy with a very practical ability for the society. There is a great significance for students studying this course , such as strengthening the knowledge of economic man-agement, perfecting sciential structure, improving the comprehensive quality, progressing in the applicability and establishing the concept of markets. The traditional teaching methods and the single assessing methods of Technology Economics Curriculum are easy to cause students lacking learning enthusiasm, and are not conducive to cultivate students' autonomous learning ability and innovational ability for a long time. According to the requirement of cultivating innovative talents , the teaching reform practice about Technology Economics Curriculum happened in Beijing University of Civil Engineering and Architecture. The reformation is related to the teaching contents, teaching methods and assessing methods, summed up

  8. Welding Curriculum.

    Science.gov (United States)

    Alaska State Dept. of Education, Juneau. Div. of Adult and Vocational Education.

    This competency-based curriculum guide is a handbook for the development of welding trade programs. Based on a survey of Alaskan welding employers, it includes all competencies a student should acquire in such a welding program. The handbook stresses the importance of understanding the principles associated with the various elements of welding.…

  9. Curriculum Analysis

    Institute of Scientific and Technical Information of China (English)

    Xu Xiaoying

    2011-01-01

    The English as a Second Language (ESL) Curriculum for grades K - 12 is a scope that builds and develops linguistic proficiency for students between the ages of six and 21 years. The ESL professionals defines ESL students as those students who are non - native English speakers and who may or may not have English proficiency.

  10. Research on Job-Oriented Curriculum System Construction for Computer Network Technology Majors%以工作岗位为导向的计算机网络技术专业课程体系建设研究

    Institute of Scientific and Technical Information of China (English)

    阎琦

    2012-01-01

    The computer network technology professional curriculum should be designed according to the work group after graduation,that is to say,the work group decides the jobs,and the jobs decide the profession skills,therefore according to professional skills,we design the appropriate curriculum system.From the following angles,such as computer network technology professional training objectives,curriculum system Settings,teaching methods and evaluation,the author makes a positive exploration and research.%计算机网络技术专业课程设置应以毕业生的工作岗位群为依据,形成工作岗位群对应工作岗位,工作岗位对应职业技能,职业技能对应专业课程的"四对应"课程设置形式。从计算机网络技术专业培养目标、课程体系设置、教学方法、考核等方面对计算机网络技术专业课程体系建设进行了积极的探索与研究。

  11. Re-Imagining the Medical Informatics Curriculum.

    Science.gov (United States)

    Frisse, Mark E.

    1997-01-01

    An imaginary curriculum on use of information technology for medical purposes is described. The six core courses address these topics: introduction to complexity; decisions and outcomes; scarcity and conflict; teamwork and organizations; representing knowledge and action; and groupware and collaboration. The curriculum is based on the conception…

  12. Academic Knowledge Construction and Multimodal Curriculum Development

    Science.gov (United States)

    Loveless, Douglas J., Ed.; Griffith, Bryant, Ed.; Bérci, Margaret E., Ed.; Ortlieb, Evan, Ed.; Sullivan, Pamela, Ed.

    2014-01-01

    While incorporating digital technologies into the classroom has offered new ways of teaching and learning into educational processes, it is essential to take a look at how the digital shift impacts teachers, school administration, and curriculum development. "Academic Knowledge Construction and Multimodal Curriculum Development" presents…

  13. Academic Knowledge Construction and Multimodal Curriculum Development

    Science.gov (United States)

    Loveless, Douglas J., Ed.; Griffith, Bryant, Ed.; Bérci, Margaret E., Ed.; Ortlieb, Evan, Ed.; Sullivan, Pamela, Ed.

    2014-01-01

    While incorporating digital technologies into the classroom has offered new ways of teaching and learning into educational processes, it is essential to take a look at how the digital shift impacts teachers, school administration, and curriculum development. "Academic Knowledge Construction and Multimodal Curriculum Development" presents…

  14. SUSTAINABLE CURRICULUM IN TVET

    Directory of Open Access Journals (Sweden)

    Johanna Lasonen

    2010-05-01

    Full Text Available In some European countries, students receive vocationally oriented education as early as at the age of 12. The students transfer to lower secondary school at the age of 10-13, with the youngest entrants found in Germany and Austria and the oldest ones, being at the age of 16, in the Nordic countries. The most thoroughly school-based vocational upper secondary education is provided in Finland, Sweden, Spain, Greece and Portugal. The highest proportion of vocational training delivered at the workplace is to be found in Austria (a little less than half and the Netherlands (a third, that of training combining the workplace and school in Denmark, Germany, France and the Netherlands. Curriculum denotes the formal specification of what is taught and learnt in educational or training establishments. Curricula are formally specified in such learning and teaching entities as units, courses, clusters, sequences and other specifications. Levels of curricula vary from national to student ones, and types of curricula differ from intended to learned syllabi. The traditions of curriculum vary according to national contexts and to historical periods. Curriculum development in TVET is approached from a broad technological knowledge, activity-oriented theories of learning and from the concept of vocation (Beruf. Ethics of sustainable development gives a global and future perspective to education and training. The first two chapters illustrate the global, regional and national policy context of curriculum in TVET followed by a historical discussion about a curriculum theory and didactics. Then the learning theories focus on work-based learning issues and an activity approach. Next the ethics and implementation of education for sustainable development is analysed. Finally a window to the future is opened by a national practice of workforce anticipation.

  15. Mast cells mediate malignant pleural effusion formation

    Science.gov (United States)

    Giannou, Anastasios D.; Marazioti, Antonia; Spella, Magda; Kanellakis, Nikolaos I.; Apostolopoulou, Hara; Psallidas, Ioannis; Prijovich, Zeljko M.; Vreka, Malamati; Zazara, Dimitra E.; Lilis, Ioannis; Papaleonidopoulos, Vassilios; Kairi, Chrysoula A.; Patmanidi, Alexandra L.; Giopanou, Ioanna; Spiropoulou, Nikolitsa; Harokopos, Vaggelis; Aidinis, Vassilis; Spyratos, Dionisios; Teliousi, Stamatia; Papadaki, Helen; Taraviras, Stavros; Snyder, Linda A.; Eickelberg, Oliver; Kardamakis, Dimitrios; Iwakura, Yoichiro; Feyerabend, Thorsten B.; Rodewald, Hans-Reimer; Kalomenidis, Ioannis; Blackwell, Timothy S.; Agalioti, Theodora; Stathopoulos, Georgios T.

    2015-01-01

    Mast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in human and murine malignant pleural effusions (MPEs) and evaluated the fate and function of these cells in MPE development. Evaluation of murine MPE-competent lung and colon adenocarcinomas revealed that these tumors actively attract and subsequently degranulate MCs in the pleural space by elaborating CCL2 and osteopontin. MCs were required for effusion development, as MPEs did not form in mice lacking MCs, and pleural infusion of MCs with MPE-incompetent cells promoted MPE formation. Once homed to the pleural space, MCs released tryptase AB1 and IL-1β, which in turn induced pleural vasculature leakiness and triggered NF-κB activation in pleural tumor cells, thereby fostering pleural fluid accumulation and tumor growth. Evaluation of human effusions revealed that MCs are elevated in MPEs compared with benign effusions. Moreover, MC abundance correlated with MPE formation in a human cancer cell–induced effusion model. Treatment of mice with the c-KIT inhibitor imatinib mesylate limited effusion precipitation by mouse and human adenocarcinoma cells. Together, the results of this study indicate that MCs are required for MPE formation and suggest that MC-dependent effusion formation is therapeutically addressable. PMID:25915587

  16. Mast cells and human hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Fabio Grizzi; Barbara Franceschini; Maurizio Chiriva-Internati; Young Liu; Paul L. Hermonat; Nicola Dioguardi

    2003-01-01

    AIM: To investigate the density of mast cells (MCs) in human hepatocellular carcinoma (HCC), and to determine whether the MCs density has any correlations with histopathological grading, staging or some baseline patient characteristics.METHODS: Tissue sections of 22 primary HCCs were histochemically stained with toluidine blue, in order to be able to quantify the MCs in and around the neoplasm using a computer-assisted image analysis system. HCC was staged and graded by two independent pathologists. To identify the sinusoidal capillarisation of each specimen 3μm thick sections were histochemically stained with sirius red, and semi-quantitatively evaluated by two independent observers. The data were statistically analysed using Spearman′s correlation and Student′s t-test when appropriate.RESULTS: MCs density did not correlate with the age or sex of the patients, the serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels, or the stage or grade of the HCC. No significant differences were found between the MCs density of the patients with and without hepatitis C virus infection, but they were significantly higher in the specimens showing marked sinusoidal capillarisation.CONCLUSION: The lack of any significant correlation between MCs density and the stage or grade of the neoplastic lesions suggests that there is no causal relationship between MCs recruitment and HCC. However, as capillarisation proceeds concurrently with arterial blood supply during hepatocarcinogenesis, MCs may be considered of primary importance in the transition from sinusoidal to capillary-type endothelial cells and the HCC growth.

  17. Blockade of mast cell activation reduces cutaneous scar formation.

    Science.gov (United States)

    Chen, Lin; Schrementi, Megan E; Ranzer, Matthew J; Wilgus, Traci A; DiPietro, Luisa A

    2014-01-01

    Damage to the skin initiates a cascade of well-orchestrated events that ultimately leads to repair of the wound. The inflammatory response is key to wound healing both through preventing infection and stimulating proliferation and remodeling of the skin. Mast cells within the tissue are one of the first immune cells to respond to trauma, and upon activation they release pro-inflammatory molecules to initiate recruitment of leukocytes and promote a vascular response in the tissue. Additionally, mast cells stimulate collagen synthesis by dermal fibroblasts, suggesting they may also influence scar formation. To examine the contribution of mast cells in tissue repair, we determined the effects the mast cell inhibitor, disodium cromoglycate (DSCG), on several parameters of dermal repair including, inflammation, re-epithelialization, collagen fiber organization, collagen ultrastructure, scar width and wound breaking strength. Mice treated with DSCG had significantly reduced levels of the inflammatory cytokines IL-1α, IL-1β, and CXCL1. Although DSCG treatment reduced the production of inflammatory mediators, the rate of re-epithelialization was not affected. Compared to control, inhibition of mast cell activity caused a significant decrease in scar width along with accelerated collagen re-organization. Despite the reduced scar width, DSCG treatment did not affect the breaking strength of the healed tissue. Tryptase β1 exclusively produced by mast cells was found to increase significantly in the course of wound healing. However, DSCG treatment did not change its level in the wounds. These results indicate that blockade of mast cell activation reduces scar formation and inflammation without further weakening the healed wound.

  18. Blockade of mast cell activation reduces cutaneous scar formation.

    Directory of Open Access Journals (Sweden)

    Lin Chen

    Full Text Available Damage to the skin initiates a cascade of well-orchestrated events that ultimately leads to repair of the wound. The inflammatory response is key to wound healing both through preventing infection and stimulating proliferation and remodeling of the skin. Mast cells within the tissue are one of the first immune cells to respond to trauma, and upon activation they release pro-inflammatory molecules to initiate recruitment of leukocytes and promote a vascular response in the tissue. Additionally, mast cells stimulate collagen synthesis by dermal fibroblasts, suggesting they may also influence scar formation. To examine the contribution of mast cells in tissue repair, we determined the effects the mast cell inhibitor, disodium cromoglycate (DSCG, on several parameters of dermal repair including, inflammation, re-epithelialization, collagen fiber organization, collagen ultrastructure, scar width and wound breaking strength. Mice treated with DSCG had significantly reduced levels of the inflammatory cytokines IL-1α, IL-1β, and CXCL1. Although DSCG treatment reduced the production of inflammatory mediators, the rate of re-epithelialization was not affected. Compared to control, inhibition of mast cell activity caused a significant decrease in scar width along with accelerated collagen re-organization. Despite the reduced scar width, DSCG treatment did not affect the breaking strength of the healed tissue. Tryptase β1 exclusively produced by mast cells was found to increase significantly in the course of wound healing. However, DSCG treatment did not change its level in the wounds. These results indicate that blockade of mast cell activation reduces scar formation and inflammation without further weakening the healed wound.

  19. IgE, mast cells, and eosinophils in atopic dermatitis.

    Science.gov (United States)

    Liu, Fu-Tong; Goodarzi, Heidi; Chen, Huan-Yuan

    2011-12-01

    Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific immune and inflammatory mechanisms. Atopy is among the major features of the diagnosis criteria for AD but is not an essential feature. Thus, patients diagnosed with AD can be atopic or non-atopic. This review focuses on the role of IgE, mast cells, and eosinophils in the pathogenesis of AD. The known functions of IgE in allergic inflammation suggest that IgE and IgE-mediated mast cell and eosinophil activation contribute to AD, but direct evidence supporting this is scarce. The level of IgE (thus the degree of allergic sensitization) is associated with severity of AD and contributed by abnormality of skin barrier, a key feature of AD. The function of IgE in development of AD is supported by the beneficial effect of anti-IgE therapy in a number of clinical studies. The role of mast cells in AD is suggested by the increase in the mast cell number and mast cell activation in AD lesions and the association between mast cell activation and AD. It is further suggested by their role in mouse models of AD as well as by the effect of therapeutic agents for AD that can affect mast cells. The role of eosinophils in AD is suggested by the presence of eosinophilia in AD patients and eosinophil infiltrates in AD lesions. It is further supported by information that links AD to cytokines and chemokines associated with production, recruitment, and activation of eosinophils.

  20. Mast cell chemotaxis – Chemoattractants and signaling pathways

    Directory of Open Access Journals (Sweden)

    Ivana eHalova

    2012-05-01

    Full Text Available Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and react to them by a chemotactic response. Another level of intercellular communication is attained by production of chemoattractants by activated mast cells, which results in accumulation of mast cells and other hematopoietic cells at the sites of inflammation. Mast cells express numerous surface receptors for various ligands with properties of potent chemoattractants. They include the stem cell factor recognized by c-Kit, antigen, which binds to immunoglobulin E (IgE anchored to the high affinity IgE receptor (FcRI, highly cytokinergic IgE recognized by FcRI, lipid mediator sphingosine-1-phosphate (S1P, which binds to G-protein-coupled receptors (GPCRs. Other large groups of chemoattractants are eicosanoids [prostaglandin E2 and D2, leukotriene (LT B4, LTD4 and LTC4, and others] and chemokines (CC, CXC, C and CX3X, which also bind to various GPCRs. Further noteworthy chemoattractants are isoforms of transforming growth factor (TGF , which are sensitively recognized by TGF- serine/threonine type I and II  receptors, adenosine, C1q, C3a, and C5a components of the complement, 5-hydroxytryptamine, neuroendocrine peptide catestatin, interleukin-6, tumor necrosis factor- and others. Here we discuss the major types of chemoattractants recognized by mast cells, their target receptors, as well as signaling pathways they utilize. We also briefly deal with methods used for studies of mast cell chemotaxis and with ways of how these studies profited from the results obtained in other cellular systems.

  1. 基于开源技术的软件工程课程体系改革探索%Reform Exploration of the Open-source-technology-based Software Engineering Curriculum

    Institute of Scientific and Technical Information of China (English)

    杜兴; 龚伟

    2014-01-01

    The present situation of the curriculum of Software En-gineering, the advantage of the open source software and the de-mand of qualified personnel of open source software are analyzed. Based on the analysis, a thought of constructing open-source-technology-based Software Engineering curriculum is proposed. And the course reform is explored in practice.%分析了软件工程专业课程体系设置的现状、开源软件的优势以及社会对开源软件人才的需求,提出了建设基于开源技术的软件工程课程体系的思路,并在教学实践中进行了课程改革探索。

  2. 中小学教师信息技术与课程整合能力评估研究%Assessment Study about Teachers’Ability to Integrate Information Technology into Curriculum in Secondary and Elementary Schools

    Institute of Scientific and Technical Information of China (English)

    张均兵

    2015-01-01

    如何评估中小学教师信息技术与课程整合能力是一个重要的研究课题。为了配合全国中小学教师信息技术应用能力提升工程的开展,本文在梳理信息技术与课程整合的一系列基本问题的基础上,着重介绍了全国中小学教师教育技术水平考试整合评估的特点及其整合标准。希望该研究能为提升工程的测评提供某些借鉴。%How to assess teachers’ability to integrate information technology into curriculum in secondary and elementary schools is an important research topic. In order to meet the project to enhance national teacher ’s skill of applied information technology in secondary and elementary schools to carry out, on the basis of carding a series of basic questions of integrating information technology into curriculum, this paper highlights characteristics in integrating assessment and integrating standards about National Teacher’s Skill of Applied Information Technology in Secondary and Elementary School. I hope this research can provide some reference for the assessment of upgrade project.

  3. 基于创新理念的电子技术教学改革研究%Teaching Reform of Electronic Technology Curriculum Based on Innovative Instruction Theory

    Institute of Scientific and Technical Information of China (English)

    李聪聪; 高立艾; 侯晨伟

    2014-01-01

    创新理念依据每个学生的个性发展,实施因材施教,培养学生的创新精神和创新能力。在电子技术课程教学中,传统的教学理念已不适应学科发展和新世纪对创新人才培养的要求,必须进行教学改革。本文以创新教学理念为指导,构建了适合创新人才培养、满足电子技术发展需求的电子技术课程理论与实践教学体系。本研究成果对高校电子技术课程教学改革和创新人才的培养具有一定理论指导意义。%Based on personality development of students, innovation instruction theory is to teach students in accordance with their aptitude, so as to cultivate their innovation spirit and innovation ability. In the teaching of electronic technology curriculum, traditional teaching method cannot keep pace with the discipline’s development and meet the urgent need of innovative talents in new age, it need reform urgently. With the guidance of innovative instruction theory, the theory and practice teaching system of electronic technology curriculum was constructed in this paper, which met the demand of electronic technology development and was suitable for innovative talent training. The research results had a certain theoretical guiding significance for the teaching reform of electronic technology curriculum and the cultivation of innovative talents.

  4. Mercury induces inflammatory mediator release from human mast cells

    Directory of Open Access Journals (Sweden)

    Peterson Erika

    2010-03-01

    Full Text Available Abstract Background Mercury is known to be neurotoxic, but its effects on the immune system are less well known. Mast cells are involved in allergic reactions, but also in innate and acquired immunity, as well as in inflammation. Many patients with Autism Spectrum Disorders (ASD have "allergic" symptoms; moreover, the prevalence of ASD in patients with mastocytosis, characterized by numerous hyperactive mast cells in most tissues, is 10-fold higher than the general population suggesting mast cell involvement. We, therefore, investigated the effect of mercuric chloride (HgCl2 on human mast cell activation. Methods Human leukemic cultured LAD2 mast cells and normal human umbilical cord blood-derived cultured mast cells (hCBMCs were stimulated by HgCl2 (0.1-10 μM for either 10 min for beta-hexosaminidase release or 24 hr for measuring vascular endothelial growth factor (VEGF and IL-6 release by ELISA. Results HgCl2 induced a 2-fold increase in β-hexosaminidase release, and also significant VEGF release at 0.1 and 1 μM (311 ± 32 pg/106 cells and 443 ± 143 pg/106 cells, respectively from LAD2 mast cells compared to control cells (227 ± 17 pg/106 cells, n = 5, p 2 (0.1 μM to the proinflammatory neuropeptide substance P (SP, 0.1 μM had synergestic action in inducing VEGF from LAD2 mast cells. HgCl2 also stimulated significant VEGF release (360 ± 100 pg/106 cells at 1 μM, n = 5, p 6 cells, and IL-6 release (466 ± 57 pg/106 cells at 0.1 μM compared to untreated cells (13 ± 25 pg/106 cells, n = 5, p 2 (0.1 μM to SP (5 μM further increased IL-6 release. Conclusions HgCl2 stimulates VEGF and IL-6 release from human mast cells. This phenomenon could disrupt the blood-brain-barrier and permit brain inflammation. As a result, the findings of the present study provide a biological mechanism for how low levels of mercury may contribute to ASD pathogenesis.

  5. Microvessel and mast cell densities in malignant laryngeal neoplasm

    Directory of Open Access Journals (Sweden)

    Balica Nicolae Constantin

    2014-01-01

    Full Text Available Laryngeal neoplasm contributes to 30-40% of carcinomas of the head and neck. Mast cells are normal connective tissue residents, well represented in the respiratory tract. Experimental evidence suggests that the growth of a tumor beyond a certain size requires angiogenesis, which may also permit metastasis. The aim of this study was to evaluate the correlation between mast cell density, microvascular density, histopathological type and histological grade. Our study included 38 laryngeal carcinomas as follows: adenoid cystic carcinoma (2 cases, malignant papilloma (2 cases and squamous cell carcinoma (34 cases. The combined technique of CD 34-alcian blue safranin (ABS was used to identify microvessel and mast cell density, which was quantified by the hot spot method. A significant correlation was found between both mast cell and microvascular density, and G1/G2 histological grade (p=0.002 and p=0.004, respectively. Squamous cell carcinoma was significantly correlated with mast cell density (p=0.003, but not with microvascular density (p=0.454.

  6. Borrelia burgdorferi Spirochetes Induce Mast Cell Activation and Cytokine Release

    Science.gov (United States)

    Talkington, Jeffrey; Nickell, Steven P.

    1999-01-01

    The Lyme disease spirochete, Borrelia burgdorferi, is introduced into human hosts via tick bites. Among the cell types present in the skin which may initially contact spirochetes are mast cells. Since spirochetes are known to activate a variety of cell types in vitro, we tested whether B. burgdorferi spirochetes could activate mast cells. We report here that freshly isolated rat peritoneal mast cells or mouse MC/9 mast cells cultured in vitro with live or freeze-thawed B. burgdorferi spirochetes undergo low but detectable degranulation, as measured by [5-3H] hydroxytryptamine release, and they synthesize and secrete the proinflammatory cytokine tumor necrosis factor alpha (TNF-α). In contrast to findings in previous studies, where B. burgdorferi-associated activity was shown to be dependent upon protein lipidation, mast cell TNF-α release was not induced by either lipidated or unlipidated recombinant OspA. This activity was additionally shown to be protease sensitive and surface expressed. Finally, comparisons of TNF-α-inducing activity in known low-, intermediate-, and high-passage B. burgdorferi B31 isolates demonstrated passage-dependent loss of activity, indicating that the activity is probably plasmid encoded. These findings document the presence in low-passage B. burgdorferi spirochetes of a novel lipidation-independent activity capable of inducing cytokine release from host cells. PMID:10024550

  7. Effect of methylmercury on the rat mast cell degranulation

    Science.gov (United States)

    Graevskaya, E. E.; Yasutake, A.; Aramai, R.; Rubin, A. B.

    2003-05-01

    Methylmercury is the well-known neurotoxicant as weil as a modulator of the immune system. We investigated the effects of MeHg on the rat mast cell degranulation induced by nonimmunological stimuli (the selective liberator of histamine, compound 48/80, and calcium ionophore A23187) both in vivo and in vitro. In 8, 12 and 15 days afterthe final administration of MeHg we observed the suppression of calcium ionophore A23187-and 48/80-induced histamine release, which enhanced with time. In experiments in vitro incubation of peritoneal mast cells with MeHg alone in the dose range 10^{-8} to 10^{-6} did not induce mast cell degranulation, however modified the activation of mast cells by compound 48/80, and calcium ionophore A23187. We observed activation of stimulated secretion by preliminary incubation with low dose of MeHg 10^{-8} M and inhibition by dose of MeHg 10^{-6} M. These results show that MeHg treatment can modify mast cell function in vivo and in vitro and provide insight into the understanding what role this cell has in the pathogenesis of Minamata disease-comlected disorders.

  8. The Role of Mast Cells in Irritable Bowel Syndrome

    Directory of Open Access Journals (Sweden)

    Kang Nyeong Lee

    2016-01-01

    Full Text Available Irritable bowel syndrome (IBS is one of the most common functional gastrointestinal disorders, but its treatment is unsatisfactory as its pathophysiology is multifactorial. The putative factors of IBS pathophysiology are visceral hypersensitivity and intestinal dysmotility, also including psychological factors, dysregulated gut-brain axis, intestinal microbiota alterations, impaired intestinal permeability, and mucosal immune alterations. Recently, mucosal immune alterations have received much attention with the role of mast cells in IBS. Mast cells are abundant in the intestines and function as intestinal gatekeepers at the interface between the luminal environment in the intestine and the internal milieu under the intestinal epithelium. As a gatekeeper at the interface, mast cells communicate with the adjacent cells such as epithelial, neuronal, and other immune cells throughout the mediators released when they themselves are activated. Many studies have suggested that mast cells play a role in the pathophysiology of IBS. This review will focus on studies of the role of mast cell in IBS and the limitations of studies and will also consider future directions.

  9. The role of mast cells in treatment of scabies.

    Science.gov (United States)

    Amer, M; Mostafa, F F; Nasr, A N; el-Harras, M

    1995-03-01

    The purpose of this study was to recognize the role of mast cells in the pathogenesis of scabies. One hundred and fifty patients and 10 controls were included in the study. Group 1 included 20 patients without previous treatment. In group 2, 80 patients were treated with antiscabietic drugs. Group 3 had 50 patients who received an antiscabietic drug followed by 3 days of crotamiton. Diurnal and nocturnal skin biopsies were taken from group 1. In groups 2 and 3, the biopsies were taken after 2 weeks of treatment. Sections were cut and stained by hematoxylin and eosin and Giemsa stains. Mast cells were increased in diurnal and nocturnal biopsies. Evident degranulation of mast cells was detected in nocturnal biopsies. The mast cell number decreased to half its pretreatment number in patients treated with antiscabietic drugs and to its normal number in patients treated with antiscabietic drugs followed by 3 days with crotamiton. The number of mast cells are increased in scabietic lesions. This plays a role in the pathogenesis of the clinical and histologic picture of scabies. We recommend that an antiscabietic drug should be followed by 3 days of crotamiton in the treatment of scabies.

  10. Mast cell subsets and neuropeptides in leprosy reactions

    Directory of Open Access Journals (Sweden)

    Antunes Sérgio Luiz Gomes

    2003-01-01

    Full Text Available The immunohistochemical identification of neuropeptides (calcitonin gene-related peptide, vasoactive intestinal polypeptide, substance P, alpha-melanocyte stimulating hormone and gamma-melanocyte stimulating hormone quantification of mast cells and their subsets (tryptase/chymase-immunoreactive mast cells = TCMC and tryptase-immunoreactive mast cells = TMC were determined in biopsies of six patients with leprosy reactions (three patients with type I reaction and three with type II. Biopsies were compared with those taken from the same body site in the remission stage of the same patient. We found a relative increase of TMC in the inflammatory infiltrate of the reactional biopsies compared to the post-reactional biopsy. Also, the total number of mast cells and the TMC/TCMC ratio in the inflammatory infiltrate was significantly higher than in the intervening dermis of the biopsies of both periods. No significant difference was found regarding neuroptide expression in the reactional and post-reactional biopsies. The relative increase of TMC in the reactional infiltrates could implicate this mast cell subset in the reported increase of the immune response in leprosy reactions.

  11. Mast cell activation contributes to sickle cell pathobiology and pain in mice

    OpenAIRE

    2013-01-01

    Inhibition of mast cells with cromolyn or imatinib results in reduced systemic inflammation and neurogenic inflammation in sickle mice.Pharmacological inhibition or genetic depletion of mast cells in sickle mice ameliorates chronic and hypoxia/reoxygenation-induced pain.

  12. Expression profiling of constitutive mast cells reveals a unique identity within the immune system

    Science.gov (United States)

    Dwyer, Daniel F.; Barrett, Nora A.; Austen, K. Frank

    2016-01-01

    Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity IgE receptor and are implicated in host defense and diverse immune-mediated diseases. To better characterize the function of these cells, we assessed the transcriptional profiles of mast cells isolated from peripheral connective tissues and basophils isolated from spleen and blood. We found that mast cells were transcriptionally distinct, clustering independently from all other profiled cells, and that mast cells demonstrated considerably greater heterogeneity across tissues than previously appreciated. We observed minimal homology between mast cells and basophils, which share more overlap with other circulating granulocytes than with mast cells. Derivation of mast cell and basophil transcriptional signatures underscores their differential capacity to detect environmental signals and influence the inflammatory milieu. PMID:27135604

  13. Immunosurveillance function of human mast cell?

    Institute of Scientific and Technical Information of China (English)

    (O)ner (O)zdemir

    2005-01-01

    Mast cell (MC) is so widely recognized as a critical effector in allergic disorders that it can be difficult to think of MC in any other context. Indeed, MCs are multifunctional and recently shown that MCs can also act as antigen presenters as well as effector elements of human immune system. First observations of their possible role as anti-tumor cells in peri- or intra-tumoral tissue were mentioned five decades ago and a high content of MCs is considered as a favorable prognosis,consistent with this study. Believers of this hypothesis assumed them to be inhibitors of tumor development through their pro-apoptotic and -necrolytic granules e.g.,granzymes and TNF-α. However, some still postulate them to be enhancers of tumor development through their effects on angiogenesis due to mostly tryptase.There are also some data suggesting increased MC density causes tumor development and indicates bad prognosis. Furthermore, since MC-associated mediators have shown to influence various aspects of tumor biology, the net effect of MCs on the development/progression of tumors has been difficult to evaluate. For instance, chymase induces apoptosis in targets; yet,tryptase, another MC protease, is a well-known mitogen.MCs with these various enzyme expression patterns may mediate different functions and the predominant MC type in tissues may be determined by the environmental needs. The coexistence of tryptase-expressing MCs(MCT) and chymase and tryptase-expressing MCs (MCTC)in physiological conditions reflects a naturally occurring balance that contributes to tissue homeostasis. We have recently discussed the role and relevance of MC serine proteases in different bone marrow diseases.

  14. Functions and Imaging of Mast Cell and Neural Axis of the Gut

    OpenAIRE

    2013-01-01

    Close association between nerves and mast cells in the gut wall provides the microanatomic basis for functional interactions between these elements, supporting the hypothesis that a mast cell–nerve axis influences gut functions in health and disease. Advanced morphology and imaging techniques are now available to assess structural and functional relationships of the mast cell–nerve axis in human gut tissues. Morphologic techniques including co-labeling of mast cells and nerv...

  15. Mast cells and atopic dermatitis. Stereological quantification of mast cells in atopic dermatitis and normal human skin

    DEFF Research Database (Denmark)

    Damsgaard, T E; Olesen, A B; Sørensen, Flemming Brandt

    1997-01-01

    Stereological quantification of mast cell numbers was applied to sections of punch biopsies from lesional and nonlesional skin of atopic dermatitis patients and skin of healthy volunteers. We also investigated whether the method of staining and/or the fixative influenced the results of the determ...... the clinical score and the number of mast cell profiles per millimetre squared. Using stereological techniques, this study indicated that mast cells might participate in the inflammatory process in skin leading to atopic dermatitis.......Stereological quantification of mast cell numbers was applied to sections of punch biopsies from lesional and nonlesional skin of atopic dermatitis patients and skin of healthy volunteers. We also investigated whether the method of staining and/or the fixative influenced the results...... of the determination of the mast cell profile numbers. The punch biopsies were taken from the same four locations in both atopic dermatitis patients and normal individuals. The locations were the scalp, neck and flexure of the elbow (lesional skin), and nates (nonlesional skin). Clinical scoring was carried out...

  16. Measurement and control of the fast ion redistribution on MAST

    CERN Document Server

    Turnyanskiy, M; Akers, R J; Cecconello, M; Keeling, D L; Kirk, A; Lake, R; Pinches, S D; Sangaroon, S; Wodniak, I

    2013-01-01

    Previous experiments on MAST and other tokamaks have indicated that the level of fast ion redistribution can exceed that expected from classical diffusion and that this level increases with beam power. In this paper we present a quantification of this effect in MAST plasmas using a recently commissioned scanning neutron camera. The observed fast ion diffusivity correlates with the amplitude of n=1 energetic particle modes, indicating that they are the probable cause of the non-classical fast ion diffusion in MAST. Finally, it will be shown that broadening the fast ion pressure profile by the application of neutral beam injection at an off-axis location can mitigate the growth of these modes and result in the classical fast ion behaviour

  17. Connecticut Business Education Curriculum Guide.

    Science.gov (United States)

    Simsbury Public Schools, CT.

    This comprehensive curriculum guide was developed to enable business education teachers and administrators in Connecticut to update and upgrade their curricula, with emphasis on and information about cross credits, technology preparation (Tech Prep 2 + 2), interdisciplinary teaching, and global economics interdependence study. Preliminary…

  18. How Global Is the Curriculum?

    Science.gov (United States)

    Smith, Andrew F.

    2002-01-01

    Describes efforts to improve the global-education curriculum during mid-1970s involving the teaching of foreign language, geography, and world history and the creation of public schools with an international focus; describes the use of extracurricular activities and technology to enhance global education; discusses challenges still facing the…

  19. Curriculum revision and ICT integration

    OpenAIRE

    Atanasova-Pacemska, Tatjana

    2006-01-01

    In this paper we will present the possibilities for revision and development of the curriculum of "Math Teaching Methods" related to Child-centered methodology and ICT integration. This paper is a result of the projects: "Teacher, Technology and young learners" and "Child-centered methodology" supported by USAID and World Learning.

  20. Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2

    Institute of Scientific and Technical Information of China (English)

    Shao-heng HE; Hua XIE; Yi-ling FU

    2005-01-01

    Aim: To investigate the effects of the agonists of proteinase activated receptor (PAR)-2,and histamine on degranulation of human mast cells. Methods: Human mast cells were enzymatically dispersed from tonsil and skin tissues. The dis persed cells were then cultured with various stimuli, and tryptase and histamine levels in cell supernatants collected from challenge tubes were measured. Results:PAR-2 agonist peptide SLIGKV provoked a dose-dependent release of histamine from skin mast cells. It also induced tryptase release from tonsil mast cells, tcLIGRLO appeared less potent than SLIGKV in induction of release of histamine and tryptase. Trypsin was able to induce a "bell" shape increase in tryptase release from tonsil mast cells. It was also able to induce a dose-dependent release of histamine from both tonsil and skin mast cells. The actions of trypsin on mast cells were inhibited by soy bean trypsin inhibitor (SBTI) or α1-antitrypsin (α1-AT).Time course study revealed that both stimulated tryptase or histamine release initiated within 10 s and reached their peak release between 4 and 6 min. Pretreatment of cells with metabolic inhibitors or pertussis toxin reduced the ability of mast cells to release tryptase or histamine. Conclusion: It was demonstrated that the in vitro tryptase release properties of human tonsil and skin mast cells suggested a novel type of mast cell heterogeneity. The activation of mast cells by PAR-2 agonists indicated a self-amplification mechanism of mast cell degranulation.

  1. Immunoglobulin free light chains: new insights in mast cell activation and immunology

    NARCIS (Netherlands)

    Thio, M.

    2011-01-01

    In this thesis, several studies are described that elaborate on the biological properties of immunoglobulin free light chains (Ig-fLC) related to the activation of mast cells and effects on other cells. Mast cell degranulation through Ig-fLC requires two events. At first, mast cell-bound Ig-fLCs sho

  2. File list: ALL.Bld.50.AllAg.Mast_Cells [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Bld.50.AllAg.Mast_Cells mm9 All antigens Blood Mast Cells SRX310205,SRX310198,S...,SRX310204,SRX310199 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/ALL.Bld.50.AllAg.Mast_Cells.bed ...

  3. Changes in ocular mast cell numbers and histamine distribution during experimental autoimmune uveitis.

    Science.gov (United States)

    Lee, C H; Lang, L S; Orr, E L

    1993-01-01

    Choroidal mast cells have been implicated in experimental autoimmune uveitis (EAU), an ocular inflammatory disease induced by S-antigen. Our data confirm that choroidal mast cell numbers decrease with clinical onset of S-antigen-induced EAU in Lewis rats, and establish that the decrease is statistically significant. In addition, we find that the numbers of limbal mast cells also decrease during S-antigen-induced EAU, and that this decrease occurs earlier in the course of the disease than that observed for choroidal mast cells. Activation and degranulation of mast cells, as evidenced by decreases in mast cell number, result in the synthesis and/or release of large quantities of mast cell mediators, such as histamine. Histamine levels in EAU were found to change significantly, decreasing in the anterior portion of the eye and increasing in the choroid and retina, in concert with changes in mast cell number over the course of EAU. Mast cell mediators may actively contribute to the pathogenesis of EAU through direct enhancement of the inflammation, by stimulation of other elements of the immune system, and/or through facilitation of the blood-retinal barrier breakdown that occurs in EAU. Overall, these results add to the evidence for a mast cell role in EAU, and, in addition, show that the mast cell involvement in EAU includes the mast cells of the limbus.

  4. Familial occurrence of systemic mast cell activation disease.

    Directory of Open Access Journals (Sweden)

    Gerhard J Molderings

    Full Text Available Systemic mast cell activation disease (MCAD comprises disorders characterized by an enhanced release of mast cell mediators accompanied by accumulation of dysfunctional mast cells. Demonstration of familial clustering would be an important step towards defining the genetic contribution to the risk of systemic MCAD. The present study aimed to quantify familial aggregation for MCAD and to investigate the variability of clinical and molecular findings (e.g. somatic mutations in KIT among affected family members in three selected pedigrees. Our data suggest that systemic MCAD pedigrees include more systemic MCAD cases than would be expected by chance, i.e., compared with the prevalence of MCAD in the general population. The prevalence of MCAD suspected by symptom self-report in first-degree relatives of patients with MCAD amounted to approximately 46%, compared to prevalence in the general German population of about 17% (p<0.0001. In three families with a high familial loading of MCAD, the subtype of MCAD and the severity of mediator-related symptoms varied between family members. In addition, genetic alterations detected in KIT were variable, and included mutations at position 816 of the amino acid sequence. In conclusion, our data provide evidence for common familial occurrence of MCAD. Our findings observed in the three pedigrees together with recent reports in the literature suggest that, in familial cases (i.e., in the majority of MCAD, mutated disease-related operator and/or regulator genes could be responsible for the development of somatic mutations in KIT and other proteins important for the regulation of mast cell activity. Accordingly, the immunohistochemically different subtypes of MCAD (i.e. mast cell activation syndrome and systemic mastocytosis should be more accurately regarded as varying presentations of a common generic root process of mast cell dysfunction, than as distinct diseases.

  5. Mast cells, glia and neuroinflammation: partners in crime?

    Science.gov (United States)

    Skaper, Stephen D; Facci, Laura; Giusti, Pietro

    2014-03-01

    Glia and microglia in particular elaborate pro-inflammatory molecules that play key roles in central nervous system (CNS) disorders from neuropathic pain and epilepsy to neurodegenerative diseases. Microglia respond also to pro-inflammatory signals released from other non-neuronal cells, mainly those of immune origin such as mast cells. The latter are found in most tissues, are CNS resident, and traverse the blood-spinal cord and blood-brain barriers when barrier compromise results from CNS pathology. Growing evidence of mast cell-glia communication opens new perspectives for the development of therapies targeting neuroinflammation by differentially modulating activation of non-neuronal cells that normally control neuronal sensitization - both peripherally and centrally. Mast cells and glia possess endogenous homeostatic mechanisms/molecules that can be up-regulated as a result of tissue damage or stimulation of inflammatory responses. Such molecules include the N-acylethanolamine family. One such member, N-palmitoylethanolamine is proposed to have a key role in maintenance of cellular homeostasis in the face of external stressors provoking, for example, inflammation. N-Palmitoylethanolamine has proven efficacious in mast-cell-mediated experimental models of acute and neurogenic inflammation. This review will provide an overview of recent progress relating to the pathobiology of neuroinflammation, the role of microglia, neuroimmune interactions involving mast cells and the possibility that mast cell-microglia cross-talk contributes to the exacerbation of acute symptoms of chronic neurodegenerative disease and accelerates disease progression, as well as promoting pain transmission pathways. We will conclude by considering the therapeutic potential of treating systemic inflammation or blockade of signalling pathways from the periphery to the brain in such settings.

  6. 关于传质分离技术课程项目化教学改革探索%Project Teaching Reform on Mass Transfer Separation Technology Curriculum

    Institute of Scientific and Technical Information of China (English)

    李洪林

    2013-01-01

      课程改革是当前高职教学改革的核心任务。依据工学结合理念开发的项目化导向的《传质分离技术》课程,突出了高职教学特色。该课程对课程体系、教学内容、教学方法、教学手段、考核评价方式等方面进行了全方位改革,并按项目化教学要求改进了实训条件,采用“任务驱动、项目导向”的方法,实现了“教、学、做”一体化,收到了良好的教学效果。%The curriculum reform is the core task of teaching reform in vocational colleges. Based on the combination of learning with working, we developed the project-oriented Mass Transfer Separation Technology curriculum which highlighted the characteristics of higher vocational education. It reformed the curriculum system, teaching content, teaching method, teaching mean, and examination method etc., and improved training conditions; it used the teaching methodology of "task-driven" and "project-oriented", realized the integration of teaching, learning and doing, and received a good teaching effect.

  7. Envisioning Curriculum as Six Simultaneities

    Science.gov (United States)

    Hussain, Hanin; Conner, Lindsey; Mayo, Elaine

    2014-01-01

    This paper uses the discourse of complexity thinking to envision curriculum as six partial and coupled facets that exist simultaneously: curriculum as structure, curriculum as process, curriculum as content, curriculum as teaching, curriculum as learning and curriculum as activity. Such a curriculum is emergent and self-organising. It is emergent…

  8. Effects of staphylococcal enterotoxin B on rodent mast cells.

    OpenAIRE

    Komisar, J; Rivera, J.; Vega, A.; Tseng, J

    1992-01-01

    Staphylococcal enterotoxin B (SEB) was tested in rodent mast cell cultures for the release of serotonin. Both rat RBL-2H3 mast cells and murine peritoneal cells released serotonin after SEB stimulation in culture. Release of serotonin in RBL-2H3 cells depended on the concentration of SEB; an appreciable release was seen at 50 micrograms/ml. The release of serotonin was not due to cell death. Serotonin release could be enhanced by bradykinin but not by vasoactive intestinal peptide, substance ...

  9. Capacity Development and Strengthening for Energy Policy formulation and implementation of Sustainable Energy Projects in Indonesia CASINDO. Deliverable No. 13. Integration of Renewable Energy Technologies in the national curriculum SPECTRUM

    Energy Technology Data Exchange (ETDEWEB)

    Kamphuis, E. [ETC Nederland, Leusden (Netherlands); Permana, I. [Technical Education Development Centre TEDC, Bandung (Indonesia)

    2011-11-15

    The overall objective of the CASINDO programme is to establish a self-sustaining and self-developing structure at both the national and regional level to build and strengthen human capacity to enable the provinces of North Sumatra, Yogyakarta, Central Java, West Nusa Tenggara and Papua to formulate sound policies for renewable energy and energy efficiency and to develop and implement sustainable energy projects. This report focuses on the achievements for settling a national curriculum for Renewable Energy Technologies (RET) within the framework of national programme SPECTRUM, which includes all curricula of the medium technical schools in Indonesia.

  10. Competentiegericht curriculum en cursusontwerp

    NARCIS (Netherlands)

    Firssova, Olga; Giesbertz, Wil

    2012-01-01

    Firssova, O., & Giesbertz, W. (2011, 30 mei). Competentiegericht curriculum en cursusontwerp. Presentatie gegeven tijdens de workshop van de BKO cursus Competentiegericht curriculum en cursusontwerp, Eindhoven, Nederland: Open Universiteit.

  11. Bridging the educational research-teaching practice gap. Curriculum development, Part 1: Components of the curriculum and influences on the process of curriculum design.

    Science.gov (United States)

    Anderson, Trevor R; Rogan, John M

    2011-01-01

    This article summarizes the major components of curriculum design: vision, operationalization of the vision, design, and evaluation. It stresses that the relationship between these components is dynamic, and that the process of curriculum design does not proceed via a linear application of these components. The article then summarizes some of the major influences on curriculum design: policy, local context, societal expectations, research trends, and technology. Then, it provides examples of how these influences affect the design of a curriculum and ends with a comprehensive set of questions that instructors could use to guide their curriculum development process.

  12. Role of Mast Cells in Regulation of T Cell Responses in Experimental and Clinical Settings.

    Science.gov (United States)

    Elieh Ali Komi, Daniel; Grauwet, Korneel

    2017-09-19

    Mast cells secrete a wide spectrum of stored or newly synthesized pro-inflammatory, anti-inflammatory, and/or immunosuppressive mediators and express several costimulatory and inhibitory surface molecules. Mast cells finely tune activities of T cells, B cells, and regulatory cells and effectively contribute to the development of different T cell-associated responses by influencing their recruitment, activation, proliferation, and differentiation. The interaction between mast cells and T cells, with regard to cellular functionality and immune responses, can be assessed in both activating and inhibitory regulations. While Th2 cytokines, including IL-5 and IL-9, stimulate stem cell factor (SCF)-dependent proliferation of mast cells, Th1 cytokine IFN-γ suppresses SCF-mediated differentiation of mast cell progenitors. Mast cell mediators such as CCL5 have a role in the recruitment of CD8+ T cells to viral infection sites where their ability in clearance of viral reservoirs is needed. The capacity of mast cells in presenting antigens by classes I and II MHC molecules to CD4+ and CD8+ T cells respectively is considered one of the main antigen-dependent interactions of mast cells with T cells. Interestingly, Tregs recruit mast cells to different sites through secretion of IL-9, while the OX40L (expressed on mast cell)-OX40(expressed on T cell) interaction inhibits the extent of the mast cell degranulation. Recently, the capability of exosomes to carry regulatory receptors of the mast cell surface and their role in T cell activation has been investigated. Functional interplay between mast cells and T cell subsets has been suggested primarily by investigating their co-localization in inflamed tissues and involvement of mast cells in autoimmune diseases. In this review, the interactions of mast cells with T cells are reviewed in cell-to-cell, cytokine, and exosome categories.

  13. Poultry Products Management. 2+2+2 Articulated Curriculum in Agricultural Technology: First Year Final Report. July 1, 1989-June 30, 1990.

    Science.gov (United States)

    Northeast Texas Community Coll., Mount Pleasant.

    This guide is for an articulated two-year high school, two-year college curriculum for poultry products management developed by two postsecondary and five secondary institutions and representatives of the private sector in Texas. The guide includes the following: (1) a brief description of the occupation of poultry products manager; (2) the basic…

  14. Dairy Products Management. 2+2+2 Articulated Curriculum in Agricultural Technology: First Year Final Report. July 1, 1989-June 30, 1990.

    Science.gov (United States)

    Northeast Texas Community Coll., Mount Pleasant.

    This guide is for an articulated two-year high school, two-year college curriculum for dairy products management developed by two postsecondary and five secondary institutions and representatives of the private sector in Texas. The guide includes the following: (1) a brief description of the occupation of dairy products manager; (2) the basic…

  15. THEORETICAL AND EXPERIMENTALRESEARCH ON DYNAMIC BEHAVIOR OF GUYED MASTS UNDER WIND LOAD

    Institute of Scientific and Technical Information of China (English)

    MaXing; WangZhonggang; DengHongzhou; WangZhaomin

    2004-01-01

    A frequency-domain algorithm is presented for the dynamic analysis of guyed masts. By introducing a four-degrees-of-freedom model of a suspended cable, guyed masts are simplified as an equivalent cable-beam model. Then, based on the discrete random vibration theory, recurrence formulas for the statistical moments of the wind-induced behavior of guyed masts are developed with the wind load treated as filtered white noise excitation. The dynamic analysis of a two-level guyed mast has been illustrated. Finally. results from a wind-tunnel experiment of guyed mast are used to testify the theory developed in this paper.

  16. Correlation of nodal mast cells with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis.

    Science.gov (United States)

    Weishaar, K M; Thamm, D H; Worley, D R; Kamstock, D A

    2014-11-01

    Lymph node metastasis in dogs with mast cell tumour has been reported as a negative prognostic indicator; however, no standardized histological criteria exist to define metastatic disease. The primary aim of this study was to determine whether different histological patterns of node-associated mast cells correlate with clinical outcome in dogs with mast cell tumour. A secondary goal was to propose a criteria-defined classification system for histological evaluation of lymph node metastasis. The Colorado State University Diagnostic Medicine Center database was searched for cases of canine mast cell tumours with reported lymph node metastasis or evidence of node-associated mast cells. Additional cases were obtained from a clinical trial involving sentinel lymph node mapping and node extirpation in dogs with mast cell neoplasia. Forty-one cases were identified for inclusion in the study. Demographic data, treatment and clinical outcome were collected for each case. Lymph nodes were classified according to a novel classification system (HN0-HN3) based on the number of, distribution of, and architectural disruption by, nodal mast cells. The findings of this study indicate that characterization of nodal mast cells as proposed by this novel classification system correlates with, and is prognostic for, clinical outcome in dogs with mast cell tumours.

  17. Mast cells as key players in periodontal disease

    Directory of Open Access Journals (Sweden)

    Popovici Ramona Amina

    2014-01-01

    Full Text Available Mast cell (MC active mediators promote inflammation through changes induced in the connective tissue components of human gingiva. The aim of this study was to evaluate the distribution, mast cell density and their relationship with the degree of inflammatory infiltrate in gingiva from patients with periodontal disease. Thirty-nine cases with periodontal disease and 12 cases without significant changes to the gingival mucosa were investigated. MCs were identified on paraffin-embedded specimens by immunohistochemistry using anti-mast cell tryptase. The inflammatory infiltrate was scored from 0 to 3, and the MCs were counted using the hotspot method. Intraepithelial MCs were scored from 0 to 2. We found a significant increase of mast cell density in cases with mild and moderate inflammatory changes, and a slight decrease in patients with severe periodontal disease. We noticed a higher degranulation rate in patients with periodontal disease compared to those with healthy mucosa. Intraepithelial MCs were found in cases with periodontal disease only and were correlated with the severity of the inflammatory lesion. MCs are important cellular components of the early stages of periodontal disease. Contrary to other studies, we found that MC density and activation increases with moderate inflammation but decreases in severe inflammatory lesions. Our data suggest that MCs are key players in the progression of inflammatory lesions of the gingiva. In advanced-stage periodontal disease, intraepithelial MCs apparently play an important role, although their biological significance remains to be fully understood.

  18. Increased mast cell numbers in a calcaneal tendon overuse model

    DEFF Research Database (Denmark)

    Pingel, Jessica; Wienecke, Jacob; Kongsgaard Madsen, Mads

    2013-01-01

    Tendinopathy is often discovered late because the initial development of tendon pathology is asymptomatic. The aim of this study was to examine the potential role of mast cell involvement in early tendinopathy using a high-intensity uphill running (HIUR) exercise model. Twenty-four male Wistar ra...

  19. Mast Cell Inhibition Improves Pulmonary Vascular Remodeling in Pulmonary Hypertension

    NARCIS (Netherlands)

    Bartelds, Beatrijs; van Loon, Rosa Laura E.; Mohaupt, Saffloer; Wijnberg, Hans; Dickinson, Michael G.; Takens, Janny; van Albada, Mirjam; Berger, Rolf M. F.; Boersma, B.

    2012-01-01

    Background: Pulmonary arterial hypertension (PAH) is a progressive angioproliferative disease with high morbidity and mortality. Although the histopathology is well described, its pathogenesis is largely unknown. We previously identified the increased presence of mast cells and their markers in a ra

  20. Diagnosis and treatment of mast cell disorders: practical recommendations.

    Science.gov (United States)

    Sandes, Alex Freire; Medeiros, Raphael Salles Scortegagna; Rizzatti, Edgar Gil

    2013-01-01

    CONTEXT AND OBJECTIVE The term mastocytosis covers a group of rare disorders characterized by neoplastic proliferation and accumulation of clonal mast cells in one or more organs. The aim of this study was to assess the principal elements for diagnosing and treating these disorders. DESIGN AND SETTING Narrative review of the literature conducted at Grupo Fleury, São Paulo, Brazil. METHODS This study reviewed the scientific papers published in the PubMed, Embase (Excerpta Medica Database), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) and Cochrane Library databases that were identified using the search term "mastocytosis." RESULTS The clinical presentation of mastocytosis is remarkably heterogeneous and ranges from skin lesions that may regress spontaneously to aggressive forms associated with organ failure and short survival. Currently, seven subtypes of mastocytosis are recognized through the World Health Organization classification system for hematopoietic tumors. These disorders are diagnosed based on clinical manifestations and on identification of neoplastic mast cells using morphological, immunophenotypic, genetic and molecular methods. Abnormal mast cells display atypical and frequently spindle-shaped morphology, and aberrant expression of the CD25 and CD2 antigens. Elevation of serum tryptase is a common finding in some subtypes, and more than 90% of the patients present the D816V KIT mutation in mast cells. CONCLUSION Here, we described the most common signs and symptoms among patients with mastocytosis and suggested a practical approach for the diagnosis, classification and initial clinical treatment of mastocytosis.

  1. Defense in Depth Added to Malicious Activities Simulation Tools (MAST)

    Science.gov (United States)

    2015-09-01

    15 Figure 6. ECB Encryption...Algorithm ECB Electronic Cookbook ECDSA Elliptic Curve Digital Signature Algorithm EN End Node MAC Message Authentication Code MAST Malicious...discussion will be based on the use of AES. 16 Electronic Codebook ( ECB ) This is the simplest and the weakest mode for block ciphering. For this mode

  2. Atherosclerosis: a chronic inflammatory disease mediated by mast cells.

    Science.gov (United States)

    Conti, Pio; Shaik-Dasthagirisaeb, Yazdami

    2015-01-01

    Inflammation is a process that plays an important role in the initiation and progression of atherosclerosis and immune disease, involving multiple cell types, including macrophages, T-lymphocytes, endothelial cells, smooth muscle cells and mast cells. The fundamental damage of atherosclerosis is the atheromatous or fibro-fatty plaque which is a lesion that causes several diseases. In atherosclerosis the innate immune response, which involves macrophages, is initiated by the arterial endothelial cells which respond to modified lipoproteins and lead to Th1 cell subset activation and generation of inflammatory cytokines and chemoattractant chemokines. Other immune cells, such as CD4+ T inflammatory cells, which play a critical role in the development and progression of atherosclerosis, and regulatory T cells [Treg], which have a protective effect on the development of atherosclerosis are involved. Considerable evidence indicates that mast cells and their products play a key role in inflammation and atherosclerosis. Activated mast cells can have detrimental effects, provoking matrix degradation, apoptosis, and enhancement as well as recruitment of inflammatory cells, which actively contributes to atherosclerosis and plaque formation. Here we discuss the relationship between atherosclerosis, inflammation and mast cells.

  3. In Vitro Desensitization of Human Skin Mast Cells

    Science.gov (United States)

    Zhao, Wei; Gomez, Gregorio; Macey, Matthew; Kepley, Christopher L.

    2013-01-01

    Desensitization is a clinical procedure whereby incremental doses of a drug are administered over several hours to a sensitive patient until a therapeutic dose and clinical tolerance are achieved. Clinical tolerance may occur in part by attenuating the mast cell response. In the present study, primary human skin mast cells were used to establish and characterize an in vitro model of desensitization. Mast cells in culture were armed with allergen-specific (4-hydroxy-3-nitro-phenylacety and Der p2) and non-specific IgE antibodies, and then desensitized by incremental exposures to 4-hydroxy-3-nitrophenylacety-BSA. This desensitization procedure abrogated the subsequent degranulation response to the desensitizing allergen, to an unrelated allergen, and to IgG anti-FcεRI, but not to C5a, substance P, compound 48/80, and calcium ionophore. Desensitized cells regained their FcεRI-dependent degranulation capability by 24–48 h after free allergen had been removed. Therefore, sensitized human skin mast cells are reversibly desensitized in vitro by exposure to incremental doses of that allergen, which also cross-desensitizes them to an unrelated allergen. PMID:22009002

  4. Murine mast cells secrete and respond to interleukin-33.

    Science.gov (United States)

    Tung, Hui-Ying; Plunkett, Beverly; Huang, Shau-Ku; Zhou, Yufeng

    2014-03-01

    Interleukin-33 (IL-33) appears to play a crucial role in the expression of allergic diseases, but its cellular source and regulatory mechanisms remain to be fully elucidated. Mast cells, one of the major effecter cell populations in mediating allergy, express high levels of IL-33 receptor, ST2, and have been shown to express IL-33 transcripts. In this study, we aimed to examine the secretion of IL-33 in mast cells and their response to IL-33. We have successfully detected secreted IL-33 from cell supernatants through a modified enzyme-linked immunosorbent assay (ELISA) technique-cell-based ELISA. Activation of bone marrow-derived cultured mast cells (BMMCs) by crosslinkage of an antigen [ovalbumin (OVA)] and OVA-specific IgE mAbs significantly induced the expression of IL-33 transcripts, cytosolic and secreted proteins. In addition, the Toll-like receptor (TLR) 2 and TLR-9 ligands could trigger IL-33 mRNA expression. Exposure of BMMCs to IL-33 significantly increased the levels of IL-13 and IL-6 expression, concomitant with enhanced activation of mitogen-activated protein kinase (MAPKs) (ERK, p38, and JNK) and nuclear factor-kappa B. These results suggest that mouse BMMCs are capable of producing and serving as endogenous sources of IL-33, and that IL-33 plays an important role in regulating mast cell functions.

  5. Influence of the Meteorology Mast on a Cup Anemometer

    DEFF Research Database (Denmark)

    Hansen, Martin O. L.; Pedersen, B.M.

    1999-01-01

    The actuator disc model is applied on lattice-type meteorological masts to estimate the influence of the tower on the accuracy of the measured wind speed. Combining the results with corrections for the boom, on which the anemometer is mounted, good agreement is found for measurements made...

  6. Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.

    Science.gov (United States)

    Ohneda, Kinuko; Moriguchi, Takashi; Ohmori, Shin'ya; Ishijima, Yasushi; Satoh, Hironori; Philipsen, Sjaak; Yamamoto, Masayuki

    2014-05-01

    Although previous studies have shown that GATA1 is required for mast cell differentiation, the effects of the complete ablation of GATA1 in mast cells have not been examined. Using conditional Gata1 knockout mice (Gata1(-/y)), we demonstrate here that the complete ablation of GATA1 has a minimal effect on the number and distribution of peripheral tissue mast cells in adult mice. The Gata1(-/y) bone marrow cells were capable of differentiating into mast cells ex vivo. Microarray analyses showed that the repression of GATA1 in bone marrow mast cells (BMMCs) has a small impact on the mast cell-specific gene expression in most cases. Interestingly, however, the expression levels of mast cell tryptases in the mouse chromosome 17A3.3 were uniformly reduced in the GATA1 knockdown cells, and GATA1 was found to bind to a 500-bp region at the 5' end of this locus. Revealing a sharp contrast to that observed in the Gata1-null BMMCs, GATA2 deficiency resulted in a significant loss of the c-Kit(+) FcεRIα(+) mast cell fraction and a reduced expression of several mast cell-specific genes. Collectively, GATA2 plays a more important role than GATA1 in the regulation of most mast cell-specific genes, while GATA1 might play specific roles in mast cell functions.

  7. The production and secretion of complement component C1q by human mast cells.

    Science.gov (United States)

    van Schaarenburg, Rosanne A; Suurmond, Jolien; Habets, Kim L L; Brouwer, Mieke C; Wouters, Diana; Kurreeman, Fina A S; Huizinga, Tom W J; Toes, René E M; Trouw, Leendert A

    2016-10-01

    C1q is the initiation molecule of the classical pathway of the complement system and is produced by macrophages and immature dendritic cells. As mast cells share the same myeloid progenitor cells, we have studied whether also mast cells can produce and secrete C1q. Mast cells were generated in vitro from CD34+ progenitor cells from buffy coats or cord blood. Fully differentiated mast cells were shown by both RNA sequencing and qPCR to express C1QA, C1QB and C1QC. C1q produced by mast cells has a similar molecular make-up as serum C1q. Reconstituting C1q depleted serum with mast cell supernatant in haemolytic assays, indicated that C1q secreted by mast cells is functionally active. The level of C1q in supernatants produced under basal conditions was considerably enhanced upon stimulation with LPS, dexamethasone in combination with IFN- γ or via FcεRI triggering. Mast cells in human tissues stained positive for C1q in both healthy and in inflamed tissue. Moreover, mast cells in healthy and diseased skin appear to be the predominant C1q positive cells. Together, our data reveal that mast cells are able to produce and secrete functional active C1q and indicate mast cells as a local source of C1q in human tissue. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  8. Mast cells are important modifiers of autoimmune disease: With so much evidence, why is there controversy?

    Directory of Open Access Journals (Sweden)

    Melissa Ann Brown

    2012-06-01

    Full Text Available There is abundant evidence that mast cells are active participants in events that mediate tissue damage in autoimmune disease. Disease-associated increases in mast cell numbers accompanied by mast cell degranulation and elaboration of numerous mast cell mediators at sites of inflammation are commonly observed in many human autoimmune diseases including multiple sclerosis, rheumatoid arthritis and bullous pemphigoid. In animal models, treatment with mast cell stabilizing drugs or mast cell ablation can result in diminished disease. A variety of receptors including those engaged by antibody, complement, pathogens and intrinsic danger signals are implicated in mast cell activation in disease. Similar to their role as first responders in infection settings, mast cells likely orchestrate early recruitment of immune cells, including neutrophils, to the sites of autoimmune destruction. This co-localization promotes cellular crosstalk and activation and results in the amplification of the local inflammatory response thereby promoting and sustaining tissue damage. Despite the evidence, there is still a debate regarding the relative role of mast cells in these processes. However, by definition, mast cells can only act as accessory cells to the self-reactive T and/or antibody driven autoimmune responses. Thus, when evaluating mast cell involvement using existing and somewhat imperfect animal models of disease, their importance is sometimes obscured. However, these potent immune cells are undoubtedly major contributors to autoimmunity and should be considered as important targets for therapeutic disease intervention.

  9. Masting promotes individual- and population-level reproduction by increasing pollination efficiency.

    Science.gov (United States)

    Moreira, Xoaquín; Abdala-Roberts, Luis; Linhart, Yan B; Mooney, Kailen A

    2014-04-01

    Masting is a reproductive strategy defined as the intermittent and synchronized production of large seed crops by a plant population. The pollination efficiency hypothesis proposes that masting increases pollination success in plants. Despite its general appeal, no previous studies have used long-term data together with population- and individual-level analyses to assess pollination efficiency between mast and non-mast events. Here we rigorously tested the pollination efficiency hypothesis in ponderosa pine (Pinus ponderosa), a long-lived monoecious, wind-pollinated species, using a data set on 217 trees monitored annually for 20 years. Relative investment in male and female function by individual trees did not vary between mast and non-mast years. At both the population and individual level, the rate of production of mature female cones relative to male strobili production was higher in mast than non-mast years, consistent with the predicted benefit of reproductive synchrony on reproductive success. In addition, at the individual level we found a higher conversion of unfertilized female conelets into mature female cones during a mast year compared to a non-mast year. Collectively, parallel results at the population and individual tree level provide robust evidence for the ecological, and potentially also evolutionary, benefits of masting through increased pollination efficiency.

  10. Estimation of the total number of mast cells in the human umbilical cord. A methodological study

    DEFF Research Database (Denmark)

    Engberg Damsgaard, T M; Windelborg Nielsen, B; Sørensen, Flemming Brandt

    1992-01-01

    The aim of the present study was to estimate the total number of mast cells in the human umbilical cord. Using 50 microns-thick paraffin sections, made from a systematic random sample of umbilical cord, the total number of mast cells per cord was estimated using a combination of the optical...... disector and fractionated sampling. The mast cell of the human umbilical cord was found in Wharton's jelly, most frequently in close proximity to the three blood vessels. No consistent pattern of variation in mast cell numbers from the fetal end of the umbilical cord towards the placenta was seen....... The total number of mast cells found in the umbilical cord was 5,200,000 (median), range 2,800,000-16,800,000 (n = 7), that is 156,000 mast cells per gram umbilical cord (median), range 48,000-267,000. Thus, the umbilical cord constitutes an adequate source of mast cells for further investigation...

  11. New Kepler Data Products At MAST For Stellar Astrophysics

    Science.gov (United States)

    Fleming, Scott W.; Shiao, B.; Tseng, S.; Million, C.; Thompson, R.; Seibert, M.; Abney, F.; Donaldson, T.; Dower, T.; Fraquelli, D. A.; Handy, S.; Koekemoer, A. M.; Levay, K.; Matuskey, J.; McLean, B.; Quick, L.; Rogers, A.; Wallace, G.; White, R. L.

    2014-01-01

    The Kepler Mission has collected high-precision, time-series photometry of over 200,000 stars. The reduced lightcurves, target pixel files, and a variety of catalog metadata are already available at MAST. We present new data products and services at MAST that will further aid researchers as Kepler begins its transition to a legacy mission, particularly in the realm of stellar astrophysics. New photometric catalogs to accompany the Kepler targets have arrived at MAST within the past year, and several more will be coming in the relative future. These include the second half of the Kepler INT survey (U,g,r,i,H_alpha; available now), an improved GALEX source catalog (NUV and FUV; available now), PanSTARRS (g,r,i,z; available soon), and WISE (3.4, 4.6, 12, and 22 microns; planned). We expect searches for variability will become one of the most active areas of archive use, so MAST is including a wide range of variability statistics as part of the archive database. In addition to being searchable through database queries and web forms, each Preview page will now include a summary of these variability indices for each of the target's lightcurves within a Quarter. Along with updated NUV and FUV fluxes, a new tool at MAST called gPhoton will allow users to create time-series lightcurves, including animated movies and intensity images, from any set of GALEX photons with arbitrary aperture and bin sizes. We show some examples of the ways GALEX UV lightcurves generated with gPhoton can be used in conjunction with the Kepler data. Finally, MAST has released an initial version of its Data Discovery Portal. This one-stop, interactive web application gives users the ability to search and access data from any of MAST's missions (HST, GALEX, Kepler, FUSE, IUE, JWST, etc.), as well as any data available through the Virtual Observatory. It includes filtering options, access to interactive displays, an accompanying AstroViewer with data footprints on-sky, the ability to upload your own

  12. A restauração na trajetória de um teodolito do acervo do MAST

    Directory of Open Access Journals (Sweden)

    Marcus Granato

    2011-01-01

    Full Text Available MAST is a science and technology museum located in the grounds and architectural complex belonging to the former National Observatory in Rio de Janeiro. Soon after the museum was created, the historical heritage existing there, relating to a significant period in the history of science in Brazil, was listed by the Brazilian National Heritage Institute (Iphan and the Rio de Janeiro State Cultural Heritage Institute (Inepac in 1986 and 1987, respectively. The studies that preceded the restoration of a theodolite from the MAST collection started with an appraisal of the state of conservation of the institution's scientific instruments collection. Next, a set of pre-established criteria were used to select this object, which was in a critical state of conservation. After this, historical research was undertaken of the instrument, the composition of its main parts was determined, a study was made into its working, and finally the intervention per se was undertaken on the object. The restoration procedure involved three stages: the conservation of parts, the restoration of parts, and the replacement of missing parts. The whole process was photographed exhaustively. The procedure adopted in this study has been replicated in further restoration projects. Studies were undertaken into the conservation of scientific instruments and research was done into the construction of trajectories of objects and collections by the Archive Preservation Group, based at MAST, resulting in the identification of restoration as a singular moment in these trajectories.

  13. Construction of Entrepreneurship Education Curriculum System in High Technological Academies%高职高专院校创业教育课程体系的构建

    Institute of Scientific and Technical Information of China (English)

    苏连升

    2011-01-01

    High technological academies entrepreneurship education has some problems,so it is necessary to strengthen the construction of entrepreneurship education curriculum system.High technological academies entrepreneurship education should take the undergraduates' creative ability and comprehensive quality as purpose,take entrepreneurship sense,entrepreneurship mental quality,entrepreneurship knowledge and entrepreneurship ability as the content,construct curriculum performing system and guarantee system.%高职高专院校创业教育存在一些问题,有必要加强创业教育课程体系建设,体现高职高专院校的办学特色。高职高专创业教育课程应以培养创业素养为宗旨,以创业意愿、创业心理品质、创业能力和创业知识为内容,构建课程的实施体系和保障体系。

  14. Construction of the "integration of job, course and certificate" curriculum for the communication technology specialty%通信技术专业“岗课证融通”课程体系的构建

    Institute of Scientific and Technical Information of China (English)

    廖亮

    2011-01-01

    Employment-oriented construction of the "integration of job, course and certificate" is the key to training highly skilled communication technology personnel. This paper describes the ideas of designing the "integration of job, course and certificate" curriculum. Aimed at communication technology specialty, the paper analyzes the ability and knowledge demands for the jobs and designs a new curriculum and specific theoretical and practical course.%以就业为导向,构建岗位、课程、职业资格证书相融通的课程体系是培养通信技术高技能人才的关键所在。在介绍了岗课证融通的课程体系设计思路的基础上,针对通信技术专业,分析了岗位知识能力要求,设计了新的课程体系架构和具体的理论和实践课程。

  15. Effect of methylmercury on histamine release from rat mast cells

    Energy Technology Data Exchange (ETDEWEB)

    Graevskaya, Elizabeth E.; Rubin, Andrew B. [Moscow State University, Biological Faculty, Department of Biophysics, 119899, Vorobjovy Gory, Moscow (Russian Federation); Yasutake, Akira; Aramaki, Ryoji [National Institute for Minamata Disease, 4058-18 Hama, Minamata, Kumamoto 867-0008 (Japan)

    2003-01-01

    Methylmercury chloride (MeHgCl) is well known as a significant environmental hazard, particularly as a modulator of the immune system. As it is acknowledged that the critical effector cells in the host response participating in various biological responses are mast cells, we tried to define the possible contribution of mast cells in the development of methylmercury-evoked effects. We investigated the effects of methylmercury on the rat mast cell degranulation induced by non-immunological stimuli (the selective liberator of histamine, compound 48/80, and calcium ionophore A23187) both in vivo and in vitro. Using the cells prepared from methylmercury-intoxicated rats through a 5-day treatment of MeHgCl (10 mg/kg/day), we observed the suppression of calcium ionophore A23187- and 48/80-induced histamine release, which was enhanced with time after treatment. Similar suppression was observed in the ionophore-stimulated release, when cells were prepared from rat with a single treatment of MeHgCl (20 mg/kg). It should be noted that when cells from the control rat were pre-incubated with methylmercury in vitro at a 10{sup -8} M concentration for 10 min, A23187 and compound 48/80-stimulated histamine release was significantly enhanced. However, when the pre-incubation period was prolonged to 30 min, the release was suppressed. An increase in the methylmercury concentration to 10{sup -6} M also suppressed the histamine release. These results show that methylmercury treatment can modify mast cell function depending on concentration and time, and might provide an insight into the role of mast cells in the development of methylmercury-stimulated effects. (orig.)

  16. Linearized models for a new magnetic control in MAST

    Energy Technology Data Exchange (ETDEWEB)

    Artaserse, G., E-mail: giovanni.artaserse@enea.it [Associazione Euratom-ENEA sulla Fusione, Via Enrico Fermi 45, I-00044 Frascati (RM) (Italy); Maviglia, F.; Albanese, R. [Associazione Euratom-ENEA-CREATE sulla Fusione, Via Claudio 21, I-80125 Napoli (Italy); McArdle, G.J.; Pangione, L. [EURATOM/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxon, OX14 3DB (United Kingdom)

    2013-10-15

    Highlights: ► We applied linearized models for a new magnetic control on MAST tokamak. ► A suite of procedures, conceived to be machine independent, have been used. ► We carried out model-based simulations, taking into account eddy currents effects. ► Comparison with the EFIT flux maps and the experimental magnetic signals are shown. ► A current driven model for the dynamic simulations of the experimental data have been performed. -- Abstract: The aim of this work is to provide reliable linearized models for the design and assessment of a new magnetic control system for MAST (Mega Ampère Spherical Tokamak) using rtEFIT, which can easily be exported to MAST Upgrade. Linearized models for magnetic control have been obtained using the 2D axisymmetric finite element code CREATE L. MAST linearized models include equivalent 2D axisymmetric schematization of poloidal field (PF) coils, vacuum vessel, and other conducting structures. A plasmaless and a double null configuration have been chosen as benchmark cases for the comparison with experimental data and EFIT reconstructions. Good agreement has been found with the EFIT flux map and the experimental signals coming from magnetic probes with only few mismatches probably due to broken sensors. A suite of procedures (equipped with a user friendly interface to be run even remotely) to provide linearized models for magnetic control is now available on the MAST linux machines. A new current driven model has been used to obtain a state space model having the PF coil currents as inputs. Dynamic simulations of experimental data have been carried out using linearized models, including modelling of the effects of the passive structures, showing a fair agreement. The modelling activity has been useful also to reproduce accurately the interaction between plasma current and radial position control loops.

  17. Induction of Microglial Activation by Mediators Released from Mast Cells

    Directory of Open Access Journals (Sweden)

    Xiang Zhang

    2016-04-01

    Full Text Available Background/Aims: Microglia are the resident immune cells in the brain and play a pivotal role in immune surveillance in the central nervous system (CNS. Brain mast cells are activated in CNS disorders and induce the release of several mediators. Thus, brain mast cells, rather than microglia, are the “first responders” due to injury. However, the functional aspects of mast cell-microglia interactions remain uninvestigated. Methods: Conditioned medium from activated HMC-1 cells induces microglial activation similar to co-culture of microglia with HMC-1 cells. Primary cultured microglia were examined by flow cytometry analysis and confocal microscopy. TNF- alpha and IL-6 were measured with commercial ELISA kits. Cell signalling was analysed by Western blotting. Results: In the present study, we found that the conditioned medium from activated HMC-1 cells stimulated microglial activation and the subsequent production of the pro-inflammatory factors TNF-α and IL-6. Co-culture of microglia and HMC-1 cells with corticotropin-releasing hormone (CRH for 24, 48 and 72 hours increased TNF-α and IL-6 production. Antagonists of histamine receptor 1 (H1R, H4R, proteinase-activated receptor 2 (PAR2 or Toll-like receptor 4 (TLR4 reduced HMC-1-induced pro-inflammatory factor production and MAPK and PI3K/AKT pathway activation. Conclusions: These results imply that activated mast cells trigger microglial activation. Interactions between mast cells and microglia could constitute a new and unique therapeutic target for CNS inflammation-related diseases.

  18. Curriculum Mapping. Focus On

    Science.gov (United States)

    Molineaux, Rebecca

    2008-01-01

    This "Focus On" discusses curriculum mapping, a process that allows educators to align the curriculum both within and across grades and to ensure that the curriculum is in line with school, local, and state standards. It outlines the steps of the curriculum mapping process from planning the mapping initiative to creating and editing curriculum…

  19. PREFACE: 5th International Conference on Materials and Applications for Sensors and Transducers (IC-MAST2015)

    Science.gov (United States)

    Hristoforou, E.; Vlachos, D. S.; Giouroudi, I.; Kar-Narayan, S.; Potirakis, S.

    2016-03-01

    The 5th International Conference on Materials and Applications for Sensors and Transducers, Mykonos island, Greece, hosted about 110 oral and poster papers and more than 90 participants. IC-MAS, as an international annual conference which tries to meet the needs for various types of sensors, particularly those which may be manufactured by low cost methods (i.e. hybrid sensors, smart specialization devices, particular applications not necessarily requiring integrated micro-nano technologies), covering all types of materials and physical effects, appears to be a necessity. IC-MAST has been established as a high quality international conference by: I. Gathering together multinational researchers from all over the world, working in different materials for sensors and transducers and technical applications of sensors, but also in some cases in the management of the data coming from sensors and transducers. The careful selection of the conference place (like Aegean Sea, Budapest, Prague, Bilbao, Mykonos etc) allows for enjoying the local hospitality and sightseeing. II. Emphasizing in hybrid sensors and smart specialization devices produced by inexpensive methods, without excluding of course micro-nano technology, from all kinds of solid state, liquid and gaseous materials, as well as in particular transducer applications (design and development, as well as use of sensing data) III. Innovatively implementing the Virtual Paper Concept, allowing for large impact of research works presented in the conference by authors who either have no time or no funding support for visiting a conference; this year more than 12 virtual papers are presented in the 5th IC MAST, following a standardized procedure via the our robust and reliable Conference Site (www.icmast.net!) > IV. Allowing for lengthy technical and managerial discussions in terms of sensor, material and instrumentation development; furthermore, the different research groups gathered together are offered the particular

  20. The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy.

    Science.gov (United States)

    Wang, L D; Rao, T N; Rowe, R G; Nguyen, P T; Sullivan, J L; Pearson, D S; Doulatov, S; Wu, L; Lindsley, R C; Zhu, H; DeAngelo, D J; Daley, G Q; Wagers, A J

    2015-06-01

    Mast cells (MCs) are critical components of the innate immune system and important for host defense, allergy, autoimmunity, tissue regeneration and tumor progression. Dysregulated MC development leads to systemic mastocytosis (SM), a clinically variable but often devastating family of hematologic disorders. Here we report that induced expression of Lin28, a heterochronic gene and pluripotency factor implicated in driving a fetal hematopoietic program, caused MC accumulation in adult mice in target organs such as the skin and peritoneal cavity. In vitro assays revealed a skewing of myeloid commitment in LIN28B-expressing hematopoietic progenitors, with increased levels of LIN28B in common myeloid and basophil-MC progenitors altering gene expression patterns to favor cell fate choices that enhanced MC specification. In addition, LIN28B-induced MCs appeared phenotypically and functionally immature, and in vitro assays suggested a slowing of MC terminal differentiation in the context of LIN28B upregulation. Finally, interrogation of human MC leukemia samples revealed upregulation of LIN28B in abnormal MCs from patients with SM. This work identifies Lin28 as a novel regulator of innate immune function and a new protein of interest in MC disease.

  1. Wnt-β-Catenin Signaling Promotes the Maturation of Mast Cells

    Directory of Open Access Journals (Sweden)

    Tomoko Yamaguchi

    2016-01-01

    Full Text Available Mast cells play an important role in the pathogenesis of allergic diseases. Immature mast cells migrate into peripheral tissues from the bone marrow and undergo complete maturation. Interestingly, mast cells have characteristics similar to hematopoietic stem cells (HSCs, such as self-renewal and c-kit expression. In HSCs, Wnt signaling is involved in their maintenance and differentiation. On the other hand, the relation between Wnt signaling and mast cell differentiation is poorly understood. To study whether Wnt signals play a role in the maturation of mast cells, we studied the effect of Wnt proteins on mast cell maturation of bone marrow-derived mast cells (BMMCs. The expression levels of CD81 protein and histidine decarboxylase mRNA and activity of mast cell-specific protease were all elevated in BMMCs treated with Wnt5a. In addition, Wnt5a induced the expression of Axin2 and TCF mRNA in BMMCs. These results showed that Wnt5a could promote the maturation of mast cells via the canonical Wnt signaling pathway and provide important insights into the molecular mechanisms underlying the differentiation of mast cells.

  2. Comparative electron microscopy of basophils and mast cells, in vivo and in vitro.

    Science.gov (United States)

    Eguchi, M

    1991-01-01

    We compared the fine structure and electron microscopic cytochemical findings of basophils and mast cells from humans, guinea pigs, rabbits, mice and rats. The particulate structure was the most frequently observed and most typical structure of human and rabbit basophil granules and of guinea pig mast cell granules. The most prominent feature of guinea pig basophils and murine mast cells was that the fine structure of the granules was homogeneous. The fine structure of the granules in guinea pig basophils resembled that in murine mast cells, while the fine structure of the granules of guinea pig mast cells resembled those in human and rabbit mast cells. In mouse mast cells in culture, the majority of the granules contained small vesicles, which were also observed in human basophils in culture and in mouse basophils in vivo. The degrees of cytochemical reactivity of acid mucopolysaccharides among the species were different. Peroxidase activity was positive in most basophils and in human mast cells. Among mammals, the granules of basophils and mast cells present heterogeneous fine structure. It is of interest that the basophil granules of some species resemble the mast cell granules rather than the basophil granules of other species.

  3. Studies on the Specific Degranulation of Mast Cell Sensitized by Several Allergens in vitro

    Institute of Scientific and Technical Information of China (English)

    Yongchao Guo; Zhenxing Li; Hong Lin; Haider Samee; Jamil Khalid

    2009-01-01

    Food allergy is a major health issue worldwide. Mast cells play a very important role in the immediate hypersensitivity for which mast cell degranulation needs to be studied extensively. In this study, an approach was taken to study the characteristics of sensitized mast cell degranulation in vitro, which associated with the study of mast cells and animal models. BALB/c mice were immunized respectively by several food allergens, then blood and peritoneal mast cells were collected at different time points. A dynamic determination was carried out between mast cells and serumal IgE. Comparative analysis on sequential time points showed that there was a close coincidence between mast cell degranulation and IgE antibody titers in sensitized BALB/c mice. Furthermore, it is interesting that sensitized mast cells could implement specific degranulation against the challenges in vitro, but the closely tropomyosins induced mast cell degranulation displayed cross reactions. This is very similar to IgE resisting the allergens in vivo. The study disclosed some characteristics on mast cells, coming from sensitized BALB/c mice, degranulation in vitro. Cellular & Molecular Immunology.

  4. 弹药储供信息技术课程内容体系构建与实践%The Establishment and Practice of Ammunition Storage and Supply Information Technologies Curriculum Content System

    Institute of Scientific and Technical Information of China (English)

    蔡军锋; 宣兆龙; 武洪文

    2014-01-01

    文中针对弹药储供信息技术课程教学现状及存在问题,以培养学员信息技术运用能力和岗位任职能力为主旨,构建了弹药保障信息采集、传递、储存、处理、应用为一体的教学内容体系。探索形成了实装实训、模拟虚拟、自主创新的实践教学内容,强化了学员弹药保障信息技术运用能力提高,为培养适应建设信息化军队、打赢信息化条件下联合战争需要的弹药保障人才奠定坚实的基础。%This paper aiming at the current situation and existing problems of ammunition storage and supply information technologies curriculum,the content system of the ammunition support information collection,transmission,storage,processing, application are constructed in order to cultivate the students'ability of information technology applying ability and capacidade professional ability.The practice teaching content of the real practice,virtual simulation and independent innovation are explored and ammunition support information technology applying ability is intensified and improved for students.The curriculum reform establish the solid foundation of ammunition support talents to build informationization army and win joint war under the condition of informationization.

  5. iMAST FY2000 Annual Report

    Science.gov (United States)

    2000-01-01

    Ductile Iron •Effect of Lubricant on Durability •High-Hot-Hardness Gear Steels •Induction Hardening of Gears •Utilization of Boron Toughened Steels...individual companies. Since its inception in 1982, the Gear Research Institute has conducted technology programs in the following areas: • Austempered

  6. iMAST FY2005 Annual Report

    Science.gov (United States)

    2005-01-01

    Since its inception in 1982, the Gear Research Institute has conducted technology programs in the following areas: ◆ Austempered Ductile Iron ◆ Effect...is currently producing high-strength alloys with yield strengths of 100 ksi and ductility between 9 and 13%. Advanced Manufacturing Processes for

  7. iMAST FY2004 Annual Report

    Science.gov (United States)

    2004-01-01

    Since its inception in 1982, the Gear Research Institute has conducted technology programs in the following areas: ◆ Austempered Ductile Iron ◆ Effect...alloys. ARL is currently producing high-strength alloys with yield strengths of 100 ksi and ductility between 9 and 13%. Advanced Manufacturing

  8. Plastics Technology.

    Science.gov (United States)

    Barker, Tommy G.

    This curriculum guide is designed to assist junior high schools industrial arts teachers in planning new courses and revising existing courses in plastics technology. Addressed in the individual units of the guide are the following topics: introduction to production technology; history and development of plastics; safety; youth leadership,…

  9. 高职园艺技术专业课程体系改革的探索与实践%Exploration and Practice of the Core Curriculum Reform of Gardening Technology Program in Higher Vocational College

    Institute of Scientific and Technical Information of China (English)

    席敦芹; 杜守良; 王效华

    2014-01-01

    高职园艺技术专业课程体系的构建应以学生岗位能力培养为目标,根据区域经济发展的需求将教学内容进行重新整合;实施一体化教学模式,调动学生自主学习的积极性;探索通过改革考核方式,建设生产性、开放性的实训基地等措施为课程体系改革提供政策性保障。%The construction of curriculum system of gardening technology program in higher vocational colleges should be vocational-competence-based and the content should be reintegrated according to the needs of regional economic development. The integrated teaching should be implemented to arouse the enthusiasm of students' autonomous learning. The paper manages to explore to reform the examination methods, the construction of productive and open training bases and other measures to provide the policy guarantee for the curriculum system reform.

  10. 《安全环保技术》精品课网站建设的经济学分析%Economics Analysis of the Fine Curriculum Website Construction in "Security Environmental Protection Technology"

    Institute of Scientific and Technical Information of China (English)

    赵欣然; 许岩

    2011-01-01

    "Security Environmental Protection Technology" is a fine Curriculum which is constructed by Daqing Voeational College ,Heilongjiang province .As one of the designers of the fine Curriculum website, from the economics point, The writer discussed about the design of the train of thought,the main meaning and the features of the website, the website used economically, efficiently and conveniently is based on the above reasons.%是大庆职业学院承担建设的黑龙江省高职高专精品课程.本文作者作为该精品课程网站的设计者之一,从自己所从事的经济学专业的视角出发,多方面研究和探讨了课程网站建设过程中关于思路设计、主要内容设计及网站特色的创立等诸多问题,为该网站建设及使用过程的经济、高效、便捷打下了基础.

  11. Role And Relevance Of Mast Cells In Fungal Infections

    Directory of Open Access Journals (Sweden)

    Rohit eSaluja

    2012-06-01

    Full Text Available In addition to their detrimental role in allergic diseases, mast cells (MCs are well known to be important cells of the innate immune system. In the last decade, they have been shown to contribute significantly to optimal host defense against numerous pathogens including parasites, bacteria, and viruses. The contribution of MCs to the immune responses in fungal infections, however, is largely unknown. In this review, we first discuss key features of mast cell responses to pathogens in general and then summarize the current knowledge on the function of MCs in the defense against fungal pathogens. We especially focus on the potential and proven mechanisms by which MC can detect fungal infections and on possible MC effector mechanisms in protecting from fungal infections.

  12. FAST Mast Structural Response to Axial Loading: Modeling and Verification

    Science.gov (United States)

    Knight, Norman F., Jr.; Elliott, Kenny B.; Templeton, Justin D.; Song, Kyongchan; Rayburn, Jeffery T.

    2012-01-01

    The International Space Station s solar array wing mast shadowing problem is the focus of this paper. A building-block approach to modeling and analysis is pursued for the primary structural components of the solar array wing mast structure. Starting with an ANSYS (Registered Trademark) finite element model, a verified MSC.Nastran (Trademark) model is established for a single longeron. This finite element model translation requires the conversion of several modeling and analysis features for the two structural analysis tools to produce comparable results for the single-longeron configuration. The model is then reconciled using test data. The resulting MSC.Nastran (Trademark) model is then extended to a single-bay configuration and verified using single-bay test data. Conversion of the MSC. Nastran (Trademark) single-bay model to Abaqus (Trademark) is also performed to simulate the elastic-plastic longeron buckling response of the single bay prior to folding.

  13. Role of human mast cells and basophils in bronchial asthma.

    Science.gov (United States)

    Marone, Gianni; Triggiani, Massimo; Genovese, Arturo; De Paulis, Amato

    2005-01-01

    Mast cells and basophils are the only cells expressing the tetrameric (alphabetagamma2) structure of the high affinity receptor for IgE (FcepsilonRI) and synthesizing histamine in humans. Human FcepsilonRI+ cells are conventionally considered primary effector cells of bronchial asthma. There is now compelling evidence that these cells differ immunologically, biochemically, and pharmacologically, which suggests that they might play distinct roles in the appearance and fluctuation of the asthma phenotype. Recent data have revealed the complexity of the involvement of human mast cells and basophils in asthma and have shed light on the control of recruitment and activation of these cells in different lung compartments. Preliminary evidence suggests that these cells might not always be detrimental in asthma but, under some circumstances, they might exert a protective effect by modulating certain aspects of innate and acquired immunity and allergic inflammation.

  14. Glia, mast cells and related: new therapeutic perspectives?

    Directory of Open Access Journals (Sweden)

    Guido Orlandini

    2011-09-01

    Full Text Available Glia exerts a pathogenic role in the development and maintenance of pain. In the past, glia was considered only support material; the glia is 70 to 90 percent of the CNS cells. Normally in a resting state, it is activated by substances released from central terminals of C fibers and releases cytokines that enhance excitatory synaptic transmission in the dorsal horn of the spinal cord (that is the basis of central sensitization, with allodynia-hyperalgesia. By analogy with the role of glia, it has been suggested the importance of the mast cell, a connective ubiquitous cell filled with granules that contain histamine, heparin, serotonin, and NGF as well as lipid droplets that contain hyaluronic acid and a cell membrane on which cannabinoid receptors 1 and 2 and vanilloid are located. Nociceptive stimuli cause mast cell degranulation and the release of substances contained in the granules. ___________________________________________________

  15. Microstability analysis of pellet fuelled discharges in MAST

    CERN Document Server

    Garzotti, L; Roach, C M; Valovic, M; Dickinson, D; Naylor, G; Romanelli, M; Scannell, R; Szepesi, G

    2014-01-01

    Reactor grade plasmas are likely to be fuelled by pellet injection. This technique transiently perturbs the profiles, driving the density profile hollow and flattening the edge temperature profile. After the pellet perturbation, the density and temperature profiles relax towards their quasi-steady-state shape. Microinstabilities influence plasma confinement and will play a role in determining the evolution of the profiles in pellet fuelled plasmas. In this paper we present the microstability analysis of pellet fuelled H-mode MAST plasmas. Taking advantage of the unique capabilities of the MAST Thomson scattering system and the possibility of synchronizing the eight lasers with the pellet injection, we were able to measure the evolution of the post-pellet electron density and temperature profiles with high temporal and spatial resolution. These profiles, together with ion temperature profiles measured using a charge exchange diagnostic, were used to produce equilibria suitable for microstability analysis of th...

  16. Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism.

    Science.gov (United States)

    Liu, Xin; Wang, Junling; Zhang, Huiyun; Zhan, Mengmeng; Chen, Hanqiu; Fang, Zeman; Xu, Chiyan; Chen, Huifang; He, Shaoheng

    2016-01-01

    Mast cells are primary effector cells of allergy, and recruitment of mast cells in involved tissue is one of the key events in allergic inflammation. Tryptase is the most abundant secretory product of mast cells, but little is known of its influence on mast cell accumulation. Using mouse peritoneal model, cell migration assay, and flow cytometry analysis, we investigated role of tryptase in recruiting mast cells. The results showed that tryptase induced up to 6.7-fold increase in mast cell numbers in mouse peritoneum following injection. Inhibitors of tryptase, an antagonist of PAR-2 FSLLRY-NH2, and pretreatment of mice with anti-ICAM-1, anti-CD11a, and anti-CD18 antibodies dramatically diminished tryptase induced mast cell accumulation. On the other hand, PAR-2 agonist peptides SLIGRL-NH2 and tc-LIGRLO-NH2 provoked mast cell accumulation following injection. These implicate that tryptase induced mast cell accumulation is dependent on its enzymatic activity, activation of PAR-2, and interaction between ICAM-1 and LFA-1. Moreover, induction of trans-endothelium migration of mast cells in vitro indicates that tryptase acts as a chemoattractant. In conclusion, provocation of mast cell accumulation by mast cell tryptase suggests a novel self-amplification mechanism of mast cell accumulation. Mast cell stabilizers as well as PAR-2 antagonist agents may be useful for treatment of allergic reactions.

  17. Increased mast cell numbers in a calcaneal tendon overuse model.

    Science.gov (United States)

    Pingel, J; Wienecke, J; Kongsgaard, M; Behzad, H; Abraham, T; Langberg, H; Scott, A

    2013-12-01

    Tendinopathy is often discovered late because the initial development of tendon pathology is asymptomatic. The aim of this study was to examine the potential role of mast cell involvement in early tendinopathy using a high-intensity uphill running (HIUR) exercise model. Twenty-four male Wistar rats were divided in two groups: running group (n = 12); sedentary control group (n = 12). The running-group was exposed to the HIUR exercise protocol for 7 weeks. The calcaneal tendons of both hind limbs were dissected. The right tendon was used for histologic analysis using Bonar score, immunohistochemistry, and second harmonic generation microscopy (SHGM). The left tendon was used for quantitative polymerase chain reaction (qPCR) analysis. An increased tendon cell density in the runners were observed compared to the controls (P = 0.05). Further, the intensity of immunostaining of protein kinase B, P = 0.03; 2.75 ± 0.54 vs 1.17 ± 0.53, was increased in the runners. The Bonar score (P = 0.05), and the number of mast cells (P = 0.02) were significantly higher in the runners compared to the controls. Furthermore, SHGM showed focal collagen disorganization in the runners, and reduced collagen density (P = 0.03). IL-3 mRNA levels were correlated with mast cell number in sedentary animals. The qPCR analysis showed no significant differences between the groups in the other analyzed targets. The current study demonstrates that 7-week HIUR causes structural changes in the calcaneal tendon, and further that these changes are associated with an increased mast cell density.

  18. Mast cells express novel functional IL-15 receptor alpha isoforms.

    Science.gov (United States)

    Bulanova, Elena; Budagian, Vadim; Orinska, Zane; Krause, Hans; Paus, Ralf; Bulfone-Paus, Silvia

    2003-05-15

    Mast cells previously have been reported to be regulated by IL-15 and to express a distinct IL-15R, termed IL-15RX. To further examine IL-15 binding and signaling in mast cells, we have studied the nature of the IL-15R and some of its biological activities in these cells. In this study, we report the existence of three novel isoforms of the IL-15R alpha chain in murine bone marrow-derived mast cells as a result of an alternative exon-splicing mechanism within the IL-15R alpha gene. These correspond to new mRNA transcripts lacking exon 4; exons 3 and 4; or exons 3, 4, and 5 (IL-15R alpha Delta 4, IL-15R alpha Delta 3,4, IL-15R alpha Delta 3,4,5). After transient transfection in COS-7 cells, all IL-15R alpha isoforms associate with the Golgi apparatus, the endoplasmic reticulum, the perinuclear space, and the cell membrane. Analysis of glycosylation pattern demonstrates the usage of a single N-glycosylation site, while no O-glycosylation is observed. Importantly, IL-15 binds with high affinity to, and promotes the survival of, murine BA/F3 cells stably transfected with the IL-15R alpha isoforms. Furthermore, we report that signaling mediated by IL-15 binding to the newly identified IL-15R alpha isoforms involves the phosphorylation of STAT3, STAT5, STAT6, Janus kinase 2, and Syk kinase. Taken together, our data indicate that murine mast cells express novel, fully functional IL-15R alpha isoforms, which can explain the selective regulatory effects of IL-15 on these cells.

  19. Clonal mast cell activation syndrome with anaphylaxis to sulfites.

    Science.gov (United States)

    Cifuentes, Liliana; Ring, Johannes; Brockow, Knut

    2013-01-01

    Sulfites are rarely suspected as causative agents of immediate-type hypersensitivity. We report on a 49-year-old male patient who developed recurrent severe hypotension after food ingestion. A diagnosis of monoclonal mast cell activation syndrome was established. In the double-blind, placebo-controlled food challenge, the patient reacted to potassium metabisulfite with anaphylaxis. Copyright © 2013 S. Karger AG, Basel.

  20. TRANSP modelling of total and local neutron emission on MAST

    Science.gov (United States)

    Klimek, I.; Cecconello, M.; Gorelenkova, M.; Keeling, D.; Meakins, A.; Jones, O.; Akers, R.; Lupelli, I.; Turnyanskiy, M.; Ericsson, G.; the MAST Team

    2015-02-01

    The results of TRANSP simulations of neutron count rate profiles measured by a collimated neutron flux monitor-neutron camera (NC)—for different plasma scenarios on MAST are reported. In addition, the effect of various plasma parameters on neutron emission is studied by means of TRANSP simulation. The fast ion redistribution and losses due to fishbone modes, which belong to a wider category of energetic particle modes, are observed by the NC and modelled in TRANSP.