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Sample records for technology gauge atg

  1. ENRAF Series 854 Advanced Technology Gauge (ATG) with SPU ll Card for Leak Detector Use Acceptance Test Procedure

    International Nuclear Information System (INIS)

    SMITH, S.G.

    1999-01-01

    The following Acceptance Test Procedure was written to test the Enraf Series 854 ATG with SPU-II card prior to installation in the Tank Farms. The procedure sets various parameters and verifies the gauge and the alarms functionality

  2. Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation.

    Science.gov (United States)

    Abreu, Susana; Kriegenburg, Franziska; Gómez-Sánchez, Rubén; Mari, Muriel; Sánchez-Wandelmer, Jana; Skytte Rasmussen, Mads; Soares Guimarães, Rodrigo; Zens, Bettina; Schuschnig, Martina; Hardenberg, Ralph; Peter, Matthias; Johansen, Terje; Kraft, Claudine; Martens, Sascha; Reggiori, Fulvio

    2017-05-01

    Deconjugation of the Atg8/LC3 protein family members from phosphatidylethanolamine (PE) by Atg4 proteases is essential for autophagy progression, but how this event is regulated remains to be understood. Here, we show that yeast Atg4 is recruited onto autophagosomal membranes by direct binding to Atg8 via two evolutionarily conserved Atg8 recognition sites, a classical LC3-interacting region (LIR) at the C-terminus of the protein and a novel motif at the N-terminus. Although both sites are important for Atg4-Atg8 interaction in vivo , only the new N-terminal motif, close to the catalytic center, plays a key role in Atg4 recruitment to autophagosomal membranes and specific Atg8 deconjugation. We thus propose a model where Atg4 activity on autophagosomal membranes depends on the cooperative action of at least two sites within Atg4, in which one functions as a constitutive Atg8 binding module, while the other has a preference toward PE-bound Atg8. © 2017 The Authors.

  3. ATG16L1

    DEFF Research Database (Denmark)

    Salem, Mohammad; Ammitzboell, Mette; Nys, Kris

    2015-01-01

    (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have been associated with an increased risk of developing Crohn disease. The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong...... association with risk for developing Crohn disease. The rs2241880 variant plays a crucial role in pathogen clearance, resulting in imbalanced cytokine production, and is linked to other biological processes, such as the endoplasmic reticulum stress/unfolded protein response. In this review, we focus......Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1...

  4. The progress and trends in the nucleonic gauge technology: Experience and contribution of Japan

    International Nuclear Information System (INIS)

    Tominaga, H.

    2000-01-01

    Most of major nucleonic gauges in Japan have already passed the period of saturation in number of use in big industries. On the other hand, however, small gauges with low activity sources are expected to increasingly diffuse into smaller industries. There have been so far more unique gauges and more interesting applications in small gauges using low activity sources, which are free from legal regulation. Still at present new applications with advanced technology are being developed using such small sources. Description is given on the current status of nucleonic gauges with emphasis on development of new techniques and applications. (author)

  5. Acceptance Test Report for the 241-AN-107 Enraf Advanced Technology Gauges

    International Nuclear Information System (INIS)

    Dowell, J.L.; Enderlin, V.R.

    1995-06-01

    This Acceptance Test Report covers the results of the execution of the Acceptance Test Procedure for the 241-AN-107 Enraf Advanced Technology Gauges. The test verified the proper operation of the gauges to measure waste density and level in the 241-AN-107 tank

  6. Twenty-five-gauge vitrectomy versus 23-gauge vitrectomy in the management of macular diseases: a comparative analysis through a Health Technology Assessment model.

    Science.gov (United States)

    Grosso, Andrea; Charrier, Lorena; Lovato, Emanuela; Panico, Claudio; Mariotti, Cesare; Dapavo, Giancarlo; Chiuminatto, Roberto; Siliquini, Roberta; Gianino, Maria Michela

    2014-04-01

    Small-gauge vitreoretinal techniques have been shown to be safe and effective in the management of a wide spectrum of vitreoretinal diseases. However, the costs of the new technologies may represent a critical issue for national health systems. The aim of the study is to plan a Health Technology Assessment (HTA) by performing a comparative analysis between the 23- and 25-gauge techniques in the management of macular diseases (epiretinal membranes, macular holes, vitreo-macular traction syndrome). In this prospective study, 45-80-year-old patients undergoing vitrectomy surgery for macular disease were enrolled at the Torino Eye Hospital. In the HTA model we assessed the safety, clinical effectiveness, and cost and financial evaluation of 23-gauge compared with 25-gauge vitrectomies. Fifty patients entered the study; 14 patients underwent 23-gauge vitrectomy and 36 underwent 25-gauge vitrectomy. There was no statistically significant difference in post-operative visual acuity at 1 year between the two groups. No cases of retinal detachment or endophtalmitis were registered at 1-year follow-up. The 23-gauge technique was slightly more expensive than the 25-gauge: the total surgical costs were EUR1217.70 versus EUR1164.84 (p = 0.351). We provide a financial comparison between new vitreoretinal procedures recently introduced in the market and reimbursed by the Italian National Health System and we also stimulate a critical debate about the expensive technocratic model of medicine.

  7. Crystallization of the Atg12–Atg5 conjugate bound to Atg16 by the free-interface diffusion method

    Energy Technology Data Exchange (ETDEWEB)

    Noda, Nobuo N.; Fujioka, Yuko [Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-21, W-11, Kita-ku, Sapporo 001-0021 (Japan); Ohsumi, Yoshinori [Division of Molecular Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki 444-8585 (Japan); Inagaki, Fuyuhiko, E-mail: finagaki@pharm.hokudai.ac.jp [Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-21, W-11, Kita-ku, Sapporo 001-0021 (Japan)

    2008-05-01

    The Atg12–Atg5 conjugate was prepared by in vivo reconstitution and was crystallized with Atg16 using the free-interface diffusion method. Autophagy mediates the bulk degradation of cytoplasmic components in lysosomes/vacuoles. Five autophagy-related (Atg) proteins are involved in a ubiquitin-like protein conjugation system. Atg12 is conjugated to its sole target, Atg5, by two enzymes, Atg7 and Atg10. The Atg12–Atg5 conjugates form a multimeric complex with Atg16. Formation of the Atg12–Atg5–Atg16 ternary complex is crucial for the functions of these proteins on autophagy. Here, the expression, purification and crystallization of the Atg12–Atg5 conjugate bound to the N-terminal region of Atg16 (Atg16N) are reported. The Atg12–Atg5 conjugates were formed by co-expressing Atg5, Atg7, Atg10 and Atg12 in Eschericia coli. The Atg12–Atg5–Atg16N ternary complex was formed by mixing purified Atg12–Atg5 conjugates and Atg16N, and was further purified by gel-filtration chromatography. Crystallization screening was performed by the free-interface diffusion method. Using obtained microcrystals as seeds, large crystals for diffraction data collection were obtained by the sitting-drop vapour-diffusion method. The crystal contained one ternary complex per asymmetric unit, and diffracted to 2.6 Å resolution.

  8. Rapid and accurate biofuel moisture content gauging using magnetic resonance measurement technology

    Energy Technology Data Exchange (ETDEWEB)

    Jaervinen, T.

    2013-04-15

    Biomass is extensively utilised in energy production and as a raw material, such as for the production of liquid biofuels. All those processes will benefit if the moisture content of bio material is known in advance as accurately as possible under transient circumstances. Biofuel trade is increasingly based on the calorific value of fuels. In the first step, this also increases the need for rapid and accurate moisture content determination. During the last few years, large biofuel standardisation has been implemented, emphasising biofuel quality control at all stages of the utilisation chain. In principle, the moisture instrumental measurement can be utilised by many technologies and procedures. Typical techniques are infrared, radiofrequency, microwave, radiometric, electrical conductivity, capacitance, and impedance. Nuclear magnetic resonance (MR) and thermal neutron absorption are also applied. The MR measurement principle has been known and utilised already since the early 1950s. It has become the basic instrumental analysis tool in chemistry. It is also well-known as a very accurate method for analysing most compounds, especially substances containing hydrogen. The utilisation of MR metering is expanded extensively to medical diagnostics as a form of magnetic resonance imaging (MRI). Because of the precision of the MR principle, there have for a long time been efforts to apply it in new and different areas, and to make more user-friendly, smaller, and even portable devices. Such a device was designed by Vaisala a few years ago. VTT has utilised Vaisala's MR prototype for approximately one year for moisture content measurement of different biofuels. The first step in the use of an MR device for moisture determination was the definition of its measurement accuracy compared to the standard method (EN 14774). Those tests proved that the absolute precision seems to be comparable to the standard moisture content measurement method. It was also found out that

  9. Atg7 Activates an Autophagy-Essential Ubiquitin-like Protein Atg8 through Multi-Step Recognition.

    Science.gov (United States)

    Yamaguchi, Masaya; Satoo, Kenji; Suzuki, Hironori; Fujioka, Yuko; Ohsumi, Yoshinori; Inagaki, Fuyuhiko; Noda, Nobuo N

    2018-02-02

    Atg8 is a unique ubiquitin-like protein that is covalently conjugated with a phosphatidylethanolamine through reactions similar to ubiquitination and plays essential roles in autophagy. Atg7 is the E1 enzyme for Atg8, and it activates the C-terminal Gly116 of Atg8 using ATP. Here, we report the crystal structure of Atg8 bound to the C-terminal domain of Atg7 in an unprecedented mode. Atg8 neither contacts with the central β-sheet nor binds to the catalytic site of Atg7, both of which were observed in previously reported Atg7-Atg8 structures. Instead, Atg8 binds to the C-terminal α-helix and crossover loop, thereby changing the autoinhibited conformation of the crossover loop observed in the free Atg7 structure into a short helix and a disordered loop. Mutational analyses suggested that this interaction mode is important for the activation reaction. We propose that Atg7 recognizes Atg8 through multiple steps, which would be necessary to induce a conformational change in Atg7 that is optimal for the activation reaction. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. The dynamic Atg13-free conformation of the Atg1 EAT domain is required for phagophore expansion.

    Science.gov (United States)

    Lin, Mary G; Schöneberg, Johannes; Davies, Christopher W; Ren, Xuefeng; Hurley, James H

    2018-03-14

    Yeast macroautophagy begins with the de novo formation of a double membrane phagophore at the preautophagosomal structure (PAS), followed by its expansion into the autophagosome responsible for cargo engulfment. The kinase Atg1 is recruited to the PAS by Atg13 through interactions between the EAT domain of the former and the tMIM motif of the latter. Mass spectrometry data has shown that in the absence of Atg13, the EAT domain structure is strikingly dynamic, but the function of this Atg13-free dynamic state has been unclear. We used structure-based mutational analysis and quantitative and superresolution microscopy to show that Atg1 is present on autophagic puncta at on average twice the stoichiometry of Atg13. Moreover, Atg1 co-localizes with the expanding autophagosome in a manner dependent on Atg8 but not Atg13. We used isothermal titration calorimetry and crystal structure information to design an EAT domain mutant allele ATG1 DD that selectively perturbs the function of the Atg13-free state. Atg1 DD shows reduced PAS formation and does not support phagophore expansion, showing that the EAT domain has an essential function that is separate from its Atg13-dependent role in autophagy initiation. © 2018 by The American Society for Cell Biology.

  11. Medium- and high-pressure gauges and transducers produced by laser welding technology

    Science.gov (United States)

    Daurelio, Giuseppe; Nenci, Fabio; Cinquepalmi, Massimo; Chita, Giuseppe

    1998-07-01

    Industrial manufacturers produce many types of pressure gauges and transducers according to the applications, for gas or liquid, for high-medium and low pressure ranges. Nowadays the current production technology generally prefers to weld by micro TIG source the metallic corrugated membranes to the gauge or transducer bodies for the products, operating on the low pressure or medium pressure ranges. For the other ones, operating to high pressure range, generally the two components of the transducers are both threaded only and threaded and then circularly welded by micro TIG for the other higher range, till to 1000 bar. In this work the products, operating on the approximately equals 30 divided by 200 bar, are considered. These, when assembled on industrial plants, as an outcome of a non-correct operating sequence, give a 'shifted' electrical signal. This is due to a shift of the 'zero electrical signal' that unbalances the electrical bridge - thin layer sensor - that is the sensitive part of the product. Moreover, for the same problem, often some mechanical settlings of the transducer happen during the first pressure semi-components, with an increasing of the product manufacturing costs. In light of all this, the above referred, in this work the whole transducer has been re-designed according to the specific laser welding technology requirements. On the new product no threaded parts exist but only a circular laser welding with a full penetration depth about 2.5 divided by 3 mm high. Three different alloys have been tested according to the applications and the mechanical properties requested to the transducer. By using a 1.5 KW CO2 laser system many different working parameters have been evaluated for correlating laser parameters to the penetration depths, crown wides, interaction laser-materia times, mechanical and metallurgical properties. Moreover during the laser welding process the measurements of the maximum temperature, reached by the transducer top, has been

  12. Solution structure of the Atg1 complex: implications for the architecture of the phagophore assembly site.

    Science.gov (United States)

    Köfinger, Jürgen; Ragusa, Michael J; Lee, Il-Hyung; Hummer, Gerhard; Hurley, James H

    2015-05-05

    The biogenesis of autophagosomes commences at the phagophore assembly site (PAS), a protein-vesicle ultrastructure that is organized by the Atg1 complex. The Atg1 complex consists of the Atg1 protein kinase, the intrinsically disordered region-rich Atg13, and the dimeric double crescent-shaped Atg17-Atg31-Atg29 subcomplex. We show that the PAS contains a relatively uniform ∼28 copies of Atg17, and upon autophagy induction, similar numbers of Atg1 and Atg13 molecules. We then apply ensemble refinement of small-angle X-ray scattering to determine the solution structures of the Atg1-Atg13 and Atg17-Atg31-Atg29 subcomplexes and the Atg1 complex, using a trimmed minipentamer tractable to biophysical studies. We observe tetramers of Atg1 pentamers that assemble via Atg17-Atg31-Atg29. This leads to a model for the higher organization of the Atg1 complex in PAS scaffolding. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Nucleonic gauges

    International Nuclear Information System (INIS)

    Sowerby, B.D.

    1982-01-01

    Techniques employed in nuclear gauges for the measurement of level, thickness, density and moisture are described. The gauges include both transmission and backscatter gauges and utilize alpha particles, beta particles, neutrons or gamma radiation

  14. Crystallization and preliminary X-ray analysis of Atg3

    International Nuclear Information System (INIS)

    Yamada, Yuya; Suzuki, Nobuo N.; Fujioka, Yuko; Ichimura, Yoshinobu; Ohsumi, Yoshinori; Inagaki, Fuyuhiko

    2006-01-01

    S. cerevisiae Atg3, an E2-like enzyme that mediates the lipidation of Atg8, was crystallized and diffracted to 2.5 Å resolution. Atg3 is an E2-like enzyme that catalyzes the conjugation reaction between Atg8 and phosphatidylethanolamine (PE). The Atg8–PE conjugate is essential for autophagy, the bulk degradation process of cytoplasmic components by the vacuolar/lysosomal system. Crystals of Saccharomyces cerevisiae Atg3 have been obtained by the sitting-drop vapour-diffusion method using ammonium sulfate and lithium sulfate as precipitants. A native data set was collected from a single crystal to 2.5 Å resolution. The crystals belong to space group P4 1 or P4 3 , with unit-cell parameters a = 59.33, c = 115.22 Å, and are expected to contain one protein molecule per asymmetric unit

  15. ATG8 Expansion: A Driver of Selective Autophagy Diversification?

    Science.gov (United States)

    Kellner, Ronny; De la Concepcion, Juan Carlos; Maqbool, Abbas; Kamoun, Sophien; Dagdas, Yasin F

    2017-03-01

    Selective autophagy is a conserved homeostatic pathway that involves engulfment of specific cargo molecules into specialized organelles called autophagosomes. The ubiquitin-like protein ATG8 is a central player of the autophagy network that decorates autophagosomes and binds to numerous cargo receptors. Although highly conserved across eukaryotes, ATG8 diversified from a single protein in algae to multiple isoforms in higher plants. We present a phylogenetic overview of 376 ATG8 proteins across the green plant lineage that revealed family-specific ATG8 clades. Because these clades differ in fixed amino acid polymorphisms, they provide a mechanistic framework to test whether distinct ATG8 clades are functionally specialized. We propose that ATG8 expansion may have contributed to the diversification of selective autophagy pathways in plants. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Characterization of a novel autophagy-specific gene, ATG29

    International Nuclear Information System (INIS)

    Kawamata, Tomoko; Kamada, Yoshiaki; Suzuki, Kuninori; Kuboshima, Norihiro; Akimatsu, Hiroshi; Ota, Shinichi; Ohsumi, Mariko; Ohsumi, Yoshinori

    2005-01-01

    Autophagy is a process whereby cytoplasmic proteins and organelles are sequestered for bulk degradation in the vacuole/lysosome. At present, 16 ATG genes have been found that are essential for autophagosome formation in the yeast Saccharomyces cerevisiae. Most of these genes are also involved in the cytoplasm to vacuole transport pathway, which shares machinery with autophagy. Most Atg proteins are colocalized at the pre-autophagosomal structure (PAS), from which the autophagosome is thought to originate, but the precise mechanism of autophagy remains poorly understood. During a genetic screen aimed to obtain novel gene(s) required for autophagy, we identified a novel ORF, ATG29/YPL166w. atg29Δ cells were sensitive to starvation and induction of autophagy was severely retarded. However, the Cvt pathway operated normally. Therefore, ATG29 is an ATG gene specifically required for autophagy. Additionally, an Atg29-GFP fusion protein was observed to localize to the PAS. From these results, we propose that Atg29 functions in autophagosome formation at the PAS in collaboration with other Atg proteins

  17. Depletion of autophagy-related genes ATG3 and ATG5 in Tenebrio molitor leads to decreased survivability against an intracellular pathogen, Listeria monocytogenes.

    Science.gov (United States)

    Tindwa, Hamisi; Jo, Yong Hun; Patnaik, Bharat Bhusan; Noh, Mi Young; Kim, Dong Hyun; Kim, Iksoo; Han, Yeon Soo; Lee, Yong Seok; Lee, Bok Luel; Kim, Nam Jung

    2015-01-01

    Macroautophagy (autophagy) is an evolutionarily conserved catabolic process involved in physiological and developmental processes including cell survival, death, and innate immunity. Homologues of most of 36 originally discovered autophagy-related (ATG) genes in yeast have been characterized in higher eukaryotes including insects. In this study, the homologues of ATG3 (TmATG3) and ATG5 (TmATG5) were isolated from the coleopteran beetle, Tenebrio molitor by expressed sequence tag and RNAseq approaches. The cDNA of TmATG3 and TmATG5 comprise open-reading frame sizes of 963 and 792 bp encoding polypeptides of 320 and 263 amino acid residues, respectively. TmATG3 and TmATG5 mRNA are expressed in all developmental stages, and mainly in fat body and hemocytes of larvae. TmATG3 and TmATG5 showed an overall sequence identity of 58-95% to other insect Atg proteins. There exist clear one-to-one orthologs of TmATG3 and TmATG5 in Tribolium and that they clustered together in the gene tree. Depletion of TmATG3 and TmATG5 by RNA interference led to a significant reduction in survival ability of T. molitor larvae against an intracellular pathogen, Listeria monocytogenes. Six days post-Listeria challenge, the survival rate in the dsEGFP-injected (where EGFP is enhanced green fluorescent protein) control larvae was significantly higher (55%) compared to 4 and 3% for TmATG3 and TmATG5 double-stranded RNA injected larvae, respectively. These data suggested that TmATG3 and TmATG5 may play putative role in mediating autophagy-based clearance of Listeria in T. molitor model. © 2014 Wiley Periodicals, Inc.

  18. The yeast autophagy protease Atg4 is regulated by thioredoxin.

    Science.gov (United States)

    Pérez-Pérez, María Esther; Zaffagnini, Mirko; Marchand, Christophe H; Crespo, José L; Lemaire, Stéphane D

    2014-01-01

    Autophagy is a membrane-trafficking process whereby double-membrane vesicles called autophagosomes engulf and deliver intracellular material to the vacuole for degradation. Atg4 is a cysteine protease with an essential function in autophagosome formation. Mounting evidence suggests that reactive oxygen species may play a role in the control of autophagy and could regulate Atg4 activity but the precise mechanisms remain unclear. In this study, we showed that reactive oxygen species activate autophagy in the model yeast Saccharomyces cerevisiae and unraveled the molecular mechanism by which redox balance controls Atg4 activity. A combination of biochemical assays, redox titrations, and site-directed mutagenesis revealed that Atg4 is regulated by oxidoreduction of a single disulfide bond between Cys338 and Cys394. This disulfide has a low redox potential and is very efficiently reduced by thioredoxin, suggesting that this oxidoreductase plays an important role in Atg4 regulation. Accordingly, we found that autophagy activation by rapamycin was more pronounced in a thioredoxin mutant compared with wild-type cells. Moreover, in vivo studies indicated that Cys338 and Cys394 are required for the proper regulation of autophagosome biogenesis, since mutation of these cysteines resulted in increased recruitment of Atg8 to the phagophore assembly site. Thus, we propose that the fine-tuning of Atg4 activity depending on the intracellular redox state may regulate autophagosome formation.

  19. The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos.

    Science.gov (United States)

    Kuhn, Hallie; Sopko, Richelle; Coughlin, Margaret; Perrimon, Norbert; Mitchison, Tim

    2015-11-15

    Yolk provides an important source of nutrients during the early development of oviparous organisms. It is composed mainly of vitellogenin proteins packed into membrane-bound compartments called yolk platelets. Catabolism of yolk is initiated by acidification of the yolk platelet, leading to the activation of Cathepsin-like proteinases, but it is unknown how this process is triggered. Yolk catabolism initiates at cellularization in Drosophila melanogaster embryos. Using maternal shRNA technology we found that yolk catabolism depends on the Tor pathway and on the autophagy-initiating kinase Atg1. Whereas Atg1 was required for a burst of spatially regulated autophagy during late cellularization, autophagy was not required for initiating yolk catabolism. We propose that the conserved Tor metabolic sensing pathway regulates yolk catabolism, similar to Tor-dependent metabolic regulation on the lysosome. © 2015. Published by The Company of Biologists Ltd.

  20. Current status of nucleonic gauge applications in Brazil and the needs for the technology in Latin American countries

    International Nuclear Information System (INIS)

    Castagnet, A.C.

    2000-01-01

    Brazil is actually the only country in Latin America that design and manufacture nucleonic gauges in industrial scale for internal market and export. There are some local companies that manufacture or assemble simple first generation nucleonic gauges for density, level and thickness gauges for pulp and paper industry, metallurgy and mineral ore processing and beverage packaging. There is apparently a market saturation due to economic crisis, public concern and licence procedures. (author)

  1. Atg5-independent sequestration of ubiquitinated mycobacteria.

    Directory of Open Access Journals (Sweden)

    Cathleen A Collins

    2009-05-01

    Full Text Available Like several other intracellular pathogens, Mycobacterium marinum (Mm escapes from phagosomes into the host cytosol where it can polymerize actin, leading to motility that promotes spread to neighboring cells. However, only approximately 25% of internalized Mm form actin tails, and the fate of the remaining bacteria has been unknown. Here we show that cytosolic access results in a new and intricate host pathogen interaction: host macrophages ubiquitinate Mm, while Mm shed their ubiquitinated cell walls. Phagosomal escape and ubiquitination of Mm occurred rapidly, prior to 3.5 hours post infection; at the same time, ubiquitinated Mm cell wall material mixed with host-derived dense membrane networks appeared in close proximity to cytosolic bacteria, suggesting cell wall shedding and association with remnants of the lysed phagosome. At 24 hours post-infection, Mm that polymerized actin were not ubiquitinated, whereas ubiquitinated Mm were found within LAMP-1-positive vacuoles resembling lysosomes. Though double membranes were observed which sequestered Mm away from the cytosol, targeting of Mm to the LAMP-1-positive vacuoles was independent of classical autophagy, as demonstrated by absence of LC3 association and by Atg5-independence of their formation. Further, ubiquitination and LAMP-1 association did not occur with mutant avirulent Mm lacking ESX-1 (type VII secretion, which fail to escape the primary phagosome; apart from its function in phagosome escape, ESX-1 was not directly required for Mm ubiquitination in macrophages or in vitro. These data suggest that virulent Mm follow two distinct paths in the cytosol of infected host cells: bacterial ubiquitination is followed by sequestration into lysosome-like organelles via an autophagy-independent pathway, while cell wall shedding may allow escape from this fate to permit continued residence in the cytosol and formation of actin tails.

  2. Gauge theories

    International Nuclear Information System (INIS)

    Kenyon, I.R.

    1986-01-01

    Modern theories of the interactions between fundamental particles are all gauge theories. In the case of gravitation, application of this principle to space-time leads to Einstein's theory of general relativity. All the other interactions involve the application of the gauge principle to internal spaces. Electromagnetism serves to introduce the idea of a gauge field, in this case the electromagnetic field. The next example, the strong force, shows unique features at long and short range which have their origin in the self-coupling of the gauge fields. Finally the unification of the description of the superficially dissimilar electromagnetic and weak nuclear forces completes the picture of successes of the gauge principle. (author)

  3. Doses from portable gauges

    International Nuclear Information System (INIS)

    Linauskas, S.H.

    1988-08-01

    Field studies to measure actual radiation exposures of operators of commercial moisture-density gauges were undertaken in several regions of Canada. Newly developed bubble detector dosimeter technology and conventional dosimetry such as thermoluminescent dosimeters (TLDs), integrating electronic dosimeters (DRDs), and CR-39 neutron track-etch detectors were used to estimate the doses received by 23 moisture-density gauge operators and maintenance staff. These radiation dose estimates were supported by mapping radiation fields and accounting for the time an operator was near a gauge. Major findings indicate that gauge maintenance and servicing workers were more likely than gauge operators to receive exposures above the level of 5 mSv, and that neutron doses were roughly the same as gamma doses. Gauge operators receive approximately 75% of their dose when transporting and carrying the gauge. Dose to their hands is similar to the dose to their trunks, but the dose to their feet area is 6 to 30 times higher. Gamma radiation is the primary source of radiation contributing to operator dose

  4. Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila.

    Science.gov (United States)

    Wen, Jung-Kun; Wang, Yi-Ting; Chan, Chih-Chiang; Hsieh, Cheng-Wen; Liao, Hsiao-Man; Hung, Chin-Chun; Chen, Guang-Chao

    2017-11-16

    Autophagy is essential for maintaining cellular homeostasis and survival under various stress conditions. Autophagy-related gene 9 (Atg9) encodes a multipass transmembrane protein thought to act as a membrane carrier for forming autophagosomes. However, the molecular regulation and physiological importance of Atg9 in animal development remain largely unclear. Here, we generated Atg9 null mutant flies and found that loss of Atg9 led to shortened lifespan, locomotor defects, and increased susceptibility to stress. Atg9 loss also resulted in aberrant adult midgut morphology with dramatically enlarged enterocytes. Interestingly, inhibiting the TOR signaling pathway rescued the midgut defects of the Atg9 mutants. In addition, Atg9 interacted with PALS1-associated tight junction protein (Patj), which associates with TSC2 to regulate TOR activity. Depletion of Atg9 caused a marked decrease in TSC2 levels. Our findings revealed an antagonistic relationship between Atg9 and TOR signaling in the regulation of cell growth and tissue homeostasis.

  5. Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Kei Kitamura

    Full Text Available Autophagy is a membrane-mediated degradation process, which is governed by sequential functions of Atg proteins. Although Atg proteins are highly conserved in eukaryotes, protozoa possess only a partial set of Atg proteins. Nonetheless, almost all protozoa have the complete factors belonging to the Atg8 conjugation system, namely, Atg3, Atg4, Atg7, and Atg8. Here, we report the biochemical properties and subcellular localization of the Atg8 protein of the human malaria parasite Plasmodium falciparum (PfAtg8. PfAtg8 is expressed during intra-erythrocytic development and associates with membranes likely as a lipid-conjugated form. Fluorescence microscopy and immunoelectron microscopy show that PfAtg8 localizes to the apicoplast, a four membrane-bound non-photosynthetic plastid. Autophagosome-like structures are not observed in the erythrocytic stages. These data suggest that, although Plasmodium parasites have lost most Atg proteins during evolution, they use the Atg8 conjugation system for the unique organelle, the apicoplast.

  6. Gauge fields

    International Nuclear Information System (INIS)

    Mills, R.

    1989-01-01

    This article is a survey of the history and ideas of gauge theory. Described here are the gradual emergence of symmetry as a driving force in the shaping of physical theory; the elevation of Noether's theorem, relating symmetries to conservation laws, to a fundamental principle of nature; and the force of the idea (''the gauge principle'') that the symmetries of nature, like the interactions themselves, should be local in character. The fundamental role of gauge fields in mediating the interactions of physics springs from Noether's theorem and the gauge principle in a remarkably clean and elegant way, leaving, however, some tantalizing loose ends that might prove to be the clue to a future deeper level of understanding. The example of the electromagnetic field as the prototype gauge theory is discussed in some detail and serves as the basis for examining the similarities and differences that emerge in generalizing to non-Abelian gauge theories. The article concludes with a brief examination of the dream of total unification: all the forces of nature in a single unified gauge theory, with the differences among the forces due to the specific way in which the fundamental symmetries are broken in the local environment

  7. Biophysical characterization of Atg11, a scaffold protein essential for selective autophagy in yeast.

    Science.gov (United States)

    Suzuki, Hironori; Noda, Nobuo N

    2018-01-01

    Autophagy is an intracellular degradation system in which the formation of an autophagosome is a key event. In budding yeast, autophagosomes are generated from the preautophagosomal structure (PAS), in which Atg11 and Atg17 function as scaffolds essential for selective and nonselective types of autophagy, respectively. Structural studies have been extensively performed on Atg17, but not on Atg11, preventing us from understanding the selective type of the PAS. Here, we purified and characterized Atg11. Biophysical analyses, including analytical ultracentrifugation and CD, showed that Atg11 behaves as an elongated homodimer abundant in α-helices in solution. Moreover, truncation analyses suggested that Atg11 has a parallel coiled-coil architecture, in contrast to the antiparallel dimeric architecture of Atg17.

  8. Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts.

    Science.gov (United States)

    Fujita, Naonobu; Saitoh, Tatsuya; Kageyama, Shun; Akira, Shizuo; Noda, Takeshi; Yoshimori, Tamotsu

    2009-11-20

    A single nucleotide polymorphism in Atg16L1, an autophagy-related gene (ATG), is a risk factor for Crohn disease, a major form of chronic inflammatory bowel disease. However, it is still unknown how the Atg16L1 variant contributes to disease development. The Atg16L1 protein possesses a C-terminal WD repeat domain whose function is entirely unknown, and the Crohn disease-associated mutation (T300A) is within this domain. To elucidate the function of the WD repeat domain, we established an experimental system in which a WD repeat domain mutant of Atg16L1 is stably expressed in Atg16L1-deficient mouse embryonic fibroblasts. Using the system, we show that the Atg16L1 complex forms a dimeric complex and that the total Atg16L1 protein level is strictly maintained, possibly by the ubiquitin proteasome system. Furthermore, we show that an Atg16L1 WD repeat domain deletion and the T300A mutant have little impact on canonical autophagy and autophagy against Salmonella enterica serovar Typhimurium. Therefore, we propose that Atg16L1 T300A is differentially involved in Crohn disease and canonical autophagy.

  9. FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12-ATG5 conjugate, leading to the delay of cartilage development in achondroplasia.

    Science.gov (United States)

    Wang, Xiaofeng; Qi, Huabing; Wang, Quan; Zhu, Ying; Wang, Xianxing; Jin, Min; Tan, Qiaoyan; Huang, Qizhao; Xu, Wei; Li, Xiaogang; Kuang, Liang; Tang, Yubing; Du, Xiaolan; Chen, Di; Chen, Lin

    2015-11-02

    FGFR3 (fibroblast growth factor receptor 3) is a negative regulator of endochondral ossification. Gain-of-function mutations in FGFR3 are responsible for achondroplasia, the most common genetic form of dwarfism in humans. Autophagy, an evolutionarily conserved catabolic process, maintains chondrocyte viability in the growth plate under stress conditions, such as hypoxia and nutritional deficiencies. However, the role of autophagy and its underlying molecular mechanisms in achondroplasia remain elusive. In this study, we found activated FGFR3 signaling inhibited autophagic activity in chondrocytes, both in vivo and in vitro. By employing an embryonic bone culture system, we demonstrated that treatment with autophagy inhibitor 3-MA or chloroquine led to cartilage growth retardation, which mimics the effect of activated-FGFR3 signaling on chondrogenesis. Furthermore, we found that FGFR3 interacted with ATG12-ATG5 conjugate by binding to ATG5. More intriguingly, FGFR3 signaling was found to decrease the protein level of ATG12-ATG5 conjugate. Consistently, using in vitro chondrogenic differentiation assay system, we showed that the ATG12-ATG5 conjugate was essential for the viability and differentiation of chondrocytes. Transient transfection of ATG5 partially rescued FGFR3-mediated inhibition on chondrocyte viability and differentiation. Our findings reveal that FGFR3 inhibits the autophagic activity by decreasing the ATG12-ATG5 conjugate level, which may play an essential role in the pathogenesis of achondroplasia.

  10. Aging gauge

    Science.gov (United States)

    Betts, Robert E.; Crawford, John F.

    1989-01-01

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  11. Gauge theories

    International Nuclear Information System (INIS)

    Jarlskog, C.

    An introduction to the unified gauge theories of weak and electromagnetic interactions is given. The ingredients of gauge theories and symmetries and conservation laws lead to discussion of local gauge invariance and QED, followed by weak interactions and quantum flavor dynamics. The construction of the standard SU(2)xU(1) model precedes discussion of the unification of weak and electromagnetic interactions and weak neutral current couplings in this model. Presentation of spontaneous symmetry breaking and spontaneous breaking of a local symmetry leads to a spontaneous breaking scheme for the standard SU(2)xU(1) model. Consideration of quarks, leptons, masses and the Cabibbo angles, of the four quark and six quark models and CP violation lead finally to grand unification, followed by discussion of mixing angles in the Georgi-Glashow model, the Higgses of the SU(5) model and proton/ neutron decay in SU(5). (JIW)

  12. Gauged merons

    Science.gov (United States)

    Samoilenka, A.; Shnir, Ya.

    2018-02-01

    We construct a new class of regular soliton solutions of the gauged planar Skyrme model on the target space S2 with fractional topological charges in the scalar sector. These field configurations represent Skyrmed vortices; they have finite energy and carry topologically quantized magnetic flux Φ =2 π n , where n is an integer. Using a special version of the product ansatz as a guide, we obtain by numerical relaxation various multimeron solutions and investigate the pattern of interaction between the fractionally charged solitons. We show that, unlike the vortices in the Abelian Higgs model, the gauged merons may combine short-range repulsion and long-range attraction. Considering the strong gauge coupling limit, we demonstrate that the topological quantization of the magnetic flux is determined by the Poincaré index of the planar components ϕ⊥=ϕ1+i ϕ2 of the Skyrme field.

  13. Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors

    Science.gov (United States)

    Villa, Stefania; Legnani, Laura; Colombo, Diego; Gelain, Arianna; Lammi, Carmen; Bongiorno, Daniele; Ilboudo, Denise P.; McGee, Kellen E.; Bosch, Jürgen; Grazioso, Giovanni

    2018-01-01

    The proteins involved in the autophagy (Atg) pathway have recently been considered promising targets for the development of new antimalarial drugs. In particular, inhibitors of the protein-protein interaction (PPI) between Atg3 and Atg8 of Plasmodium falciparum retarded the blood- and liver-stages of parasite growth. In this paper, we used computational techniques to design a new class of peptidomimetics mimicking the Atg3 interaction motif, which were then synthesized by click-chemistry. Surface plasmon resonance has been employed to measure the ability of these compounds to inhibit the Atg3-Atg8 reciprocal protein-protein interaction. Moreover, P. falciparum growth inhibition in red blood cell cultures was evaluated as well as the cyto-toxicity of the compounds.

  14. Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors

    Science.gov (United States)

    Villa, Stefania; Legnani, Laura; Colombo, Diego; Gelain, Arianna; Lammi, Carmen; Bongiorno, Daniele; Ilboudo, Denise P.; McGee, Kellen E.; Bosch, Jürgen; Grazioso, Giovanni

    2018-03-01

    The proteins involved in the autophagy (Atg) pathway have recently been considered promising targets for the development of new antimalarial drugs. In particular, inhibitors of the protein-protein interaction (PPI) between Atg3 and Atg8 of Plasmodium falciparum retarded the blood- and liver-stages of parasite growth. In this paper, we used computational techniques to design a new class of peptidomimetics mimicking the Atg3 interaction motif, which were then synthesized by click-chemistry. Surface plasmon resonance has been employed to measure the ability of these compounds to inhibit the Atg3-Atg8 reciprocal protein-protein interaction. Moreover, P. falciparum growth inhibition in red blood cell cultures was evaluated as well as the cyto-toxicity of the compounds.

  15. gauge fields

    Indian Academy of Sciences (India)

    Abstract. Painlevé test (Jimbo et al [1]) for integrability for the Yang's self-dual equa- tions for SU(2) gauge fields has been revisited. Jimbo et al analysed the complex form of the equations with a rather restricted form of singularity manifold. They did not discuss exact solutions in that context. Here the analysis has been done ...

  16. Application of indirect stress measurement techniques (non strain gauge based technology) to quantify stress environments in mines

    CSIR Research Space (South Africa)

    Stacey, TR

    2002-03-01

    Full Text Available Reliable values of in situ stress are essential for the valid modelling of mine layouts. Available non-strain gauge methods are reviewed as potential practical techniques for South African mines. From this review it is concluded that the most...

  17. A Propellant Mass Gauge Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Advanced Technologies Group, Inc. proposes the development of a Liquid-Oxygen Mass Gauge, (LMG) for In-Space cryogenic storage capable of continuous monitoring of...

  18. Autophagy-regulating protease Atg4: structure, function, regulation and inhibition

    Science.gov (United States)

    Maruyama, Tatsuro; Noda, Nobuo N

    2018-01-01

    Autophagy is an intracellular degradation system that contributes to cellular homeostasis through degradation of various targets such as proteins, organelles and microbes. Since autophagy is related to various diseases such as infection, neurodegenerative diseases and cancer, it is attracting attention as a new therapeutic target. Autophagy is mediated by dozens of autophagy-related (Atg) proteins, among which Atg4 is the sole protease that regulates autophagy through the processing and deconjugating of Atg8. As the Atg4 activity is essential and highly specific to autophagy, Atg4 is a prospective target for developing autophagy-specific inhibitors. In this review article, we summarize our current knowledge of the structure, function and regulation of Atg4 including efforts to develop Atg4-specific inhibitors. PMID:28901328

  19. Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay.

    Science.gov (United States)

    Kim, Myungjin; Sandford, Erin; Gatica, Damian; Qiu, Yu; Liu, Xu; Zheng, Yumei; Schulman, Brenda A; Xu, Jishu; Semple, Ian; Ro, Seung-Hyun; Kim, Boyoung; Mavioglu, R Nehir; Tolun, Aslıhan; Jipa, Andras; Takats, Szabolcs; Karpati, Manuela; Li, Jun Z; Yapici, Zuhal; Juhasz, Gabor; Lee, Jun Hee; Klionsky, Daniel J; Burmeister, Margit

    2016-01-26

    Autophagy is required for the homeostasis of cellular material and is proposed to be involved in many aspects of health. Defects in the autophagy pathway have been observed in neurodegenerative disorders; however, no genetically-inherited pathogenic mutations in any of the core autophagy-related (ATG) genes have been reported in human patients to date. We identified a homozygous missense mutation, changing a conserved amino acid, in ATG5 in two siblings with congenital ataxia, mental retardation, and developmental delay. The subjects' cells display a decrease in autophagy flux and defects in conjugation of ATG12 to ATG5. The homologous mutation in yeast demonstrates a 30-50% reduction of induced autophagy. Flies in which Atg5 is substituted with the mutant human ATG5 exhibit severe movement disorder, in contrast to flies expressing the wild-type human protein. Our results demonstrate the critical role of autophagy in preventing neurological diseases and maintaining neuronal health.

  20. Characterization of an Autophagy-related Gene MdATG8i from apple

    Directory of Open Access Journals (Sweden)

    Ping eWang

    2016-05-01

    Full Text Available Nutrient deficiencies restrict apple (Malus sp. tree growth and productivity in Northwest China. The process of autophagy, a conserved degradation pathway in eukaryotic cells, has important roles in nutrient-recycling and helps improve plant performance during periods of nutrient-starvation. Little is known about the functioning of autophagy-related genes (ATGs in apple. In this study, one of the ATG8 gene family members MdATG8i was isolated from M. domestica. MdATG8i has conserved putative tubulin binding sites and ATG7 interaction domains. A 1865-bp promoter region cloned from apple genome DNA was predicated to have cis-regulatory elements responsive to light, environmental stresses and hormones. MdATG8i transcriptions were induced in response to leaf senescence, nitrogen depletion, and oxidative stress. At cellular level, MdATG8i protein was expressed in the nucleus and cytoplasm of onion epidermal cells. Yeast two-hybrid tests showed that MdATG8i could interact with MdATG7a and MdATG7b. In Arabidopsis, its heterologous expression was associated with enhanced vegetative growth, leaf senescence, and tolerance to nitrogen- and carbon-starvation. MdATG8i-overexpressing ‘Orin’ apple callus lines also displayed improved tolerance to nutrient-limited conditions. Our results demonstrate that MdATG8i protein could function in autophagy in a conserved way, as a positive regulator in the response to nutrient-starvation.

  1. BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy: BECN2 CCD Structure and Interaction with ATG14

    Energy Technology Data Exchange (ETDEWEB)

    Su, Minfei; Li, Yue; Wyborny, Shane; Neau, David; Chakravarthy, Srinivas; Levine, Beth; Colbert, Christopher L.; Sinha, Sangita C. (NDSU); (IIT); (Cornell); (UTSMC)

    2017-03-12

    ATG14 binding to BECN/Beclin homologs is essential for autophagy, a critical catabolic homeostasis pathway. Here, we show that the α-helical, coiled-coil domain (CCD) of BECN2, a recently identified mammalian BECN1 paralog, forms an antiparallel, curved homodimer with seven pairs of nonideal packing interactions, while the BECN2 CCD and ATG14 CCD form a parallel, curved heterodimer stabilized by multiple, conserved polar interactions. Compared to BECN1, the BECN2 CCD forms a weaker homodimer, but binds more tightly to the ATG14 CCD. Mutation of nonideal BECN2 interface residues to more ideal pairs improves homodimer self-association and thermal stability. Unlike BECN1, all BECN2 CCD mutants bind ATG14, although more weakly than wild type. Thus, polar BECN2 CCD interface residues result in a metastable homodimer, facilitating dissociation, but enable better interactions with polar ATG14 residues stabilizing the BECN2:ATG14 heterodimer. These structure-based mechanistic differences in BECN1 and BECN2 homodimerization and heterodimerization likely dictate competitive ATG14 recruitment.

  2. Introduction to gauge theories

    International Nuclear Information System (INIS)

    Wit, B. de

    1983-01-01

    In these lectures we present the key ingredients of theories with local gauge invariance. We introduce gauge invariance as a starting point for the construction of a certain class of field theories, both for abelian and nonabelian gauge groups. General implications of gauge invariance are discussed, and we outline in detail how gauge fields can acquire masses in a spontaneous fashion. (orig./HSI)

  3. Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Rahul Navale

    Full Text Available Conventional autophagy is a lysosome-dependent degradation process that has crucial homeostatic and regulatory functions in eukaryotic organisms. As malaria parasites must dispose a number of self and host cellular contents, we investigated if autophagy in malaria parasites is similar to the conventional autophagy. Genome wide analysis revealed a partial autophagy repertoire in Plasmodium, as homologs for only 15 of the 33 yeast autophagy proteins could be identified, including the autophagy marker Atg8. To gain insights into autophagy in malaria parasites, we investigated Plasmodium falciparum Atg8 (PfAtg8 employing techniques and conditions that are routinely used to study autophagy. Atg8 was similarly expressed and showed punctate localization throughout the parasite in both asexual and sexual stages; it was exclusively found in the pellet fraction as an integral membrane protein, which is in contrast to the yeast or mammalian Atg8 that is distributed among cytosolic and membrane fractions, and suggests for a constitutive autophagy. Starvation, the best known autophagy inducer, decreased PfAtg8 level by almost 3-fold compared to the normally growing parasites. Neither the Atg8-associated puncta nor the Atg8 expression level was significantly altered by treatment of parasites with routinely used autophagy inhibitors (cysteine (E64 and aspartic (pepstatin protease inhibitors, the kinase inhibitor 3-methyladenine, and the lysosomotropic agent chloroquine, indicating an atypical feature of autophagy. Furthermore, prolonged inhibition of the major food vacuole protease activity by E64 and pepstatin did not cause accumulation of the Atg8-associated puncta in the food vacuole, suggesting that autophagy is primarily not meant for degradative function in malaria parasites. Atg8 showed partial colocalization with the apicoplast; doxycycline treatment, which disrupts apicoplast, did not affect Atg8 localization, suggesting a role, but not exclusive, in

  4. Global gauge fixing in lattice gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Fachin, S.; Parrinello, C. (Physics Department, New York University, 4 Washington Place, New York, New York (USA))

    1991-10-15

    We propose a covariant, nonperturbative gauge-fixing procedure for lattice gauge theories that avoids the problem of Gribov copies. This is closely related to a recent proposal for a gauge fixing in the continuum that we review. The lattice gauge-fixed model allows both analytical and numerical investigations: on the analytical side, explicit nonperturbative calculations of gauge-dependent quantities can be easily performed in the framework of a generalized strong-coupling expansion, while on the numerical side a stochastic gauge-fixing algorithm is very naturally associated with the scheme. In both applications one can study the gauge dependence of the results, since the model actually provides a smooth'' family of gauge-fixing conditions.

  5. Technical data on nucleonic gauges

    International Nuclear Information System (INIS)

    2005-07-01

    This nucleonic gauge manual and directory provides a reference database of nucleonic control systems available to potential users in the fields of exploration, exploitation and processing of natural resources and in the manufacturing industries. It starts with background information an the general principals of nucleonic gauges, followed by portable nuclear analysis systems (PNAS), computer tomography, cost-benefit on NCS (Nucleonic Control Systems) applications and trends and transfer of NCS technology. It continues with radiation protection and safety, discusses nucleonic gauges with low radioactivity sources and ends with typical models of nucleonic gauges. The basic principles of the most popular techniques are reviewed and reference data links to suppliers are provided. Information sheets on many typical commercial devices are also included. It will help end-users to select the most suitable alternative to solve a particular problem or to measure a certain parameter in a specific process

  6. Diffraction gauging

    International Nuclear Information System (INIS)

    Wilkens, P.H.

    1978-01-01

    This system of gauging is now being designed to fit on an Excello NC lathe to measure the form, accuracy, and size of external contoured surfaces as they approach the finish machined size. A template profile of the finished workpiece, but 0.003 in. bigger on radius, will be aligned with the workpiece using a reference diameter and face on the machining fixture to leave a gap between the profile of the template and workpiece. A helium--neon laser beam will be projected through this gap using a rotating retroreflector and a fixed laser. The resulting diffraction pattern produced by the laser beam passing through the template to workpiece gap will be reflected and focused on a fixed diode array via a second retroreflector which moves and remains in optical alignment with the first. These retroreflectors will be rotated about a center that will enable the laser beam, which is shaped in a long slit, to scan the template workpiece gap from the pole to the equator of the workpiece. The characteristic diffraction pattern will be detected by the fixed diode array, and the signal levels from this array will be processed in a mini-computer programmed to produce a best fit through the two minima of the diode signals. The separation of the two minima will yield the size of the workpiece to template gap and this information will be presented to the machine tool operator

  7. Gauging Teachers' Needs with Regard to Technology- Enhanced Formative Assessment (TEFA) of 21st Century Skills in the Classroom

    NARCIS (Netherlands)

    Rusman, Ellen; Martínez-Monés, Alejandra; Boon, Jo; Rodríguez-Triana, María Jesús; Villagrá-Sobrino, Sara

    2014-01-01

    Several trends in society have led to a request towards schools to integrate 21st Century Skills and technology enhanced formative assessment (TEFA) in their curricula. Although there are frameworks defined at an international level, implementation of technology enhanced formative assessment

  8. Outcomes of peripheral blood stem cell transplantation patients from HLA-mismatched unrelated donor with antithymocyte globulin (ATG)-Thymoglobulin versus ATG-Fresenius: a single-center study.

    Science.gov (United States)

    Huang, Wenrong; Zhao, Xiaoli; Tian, Yamin; Cao, Tingting; Li, Yanfen; Liu, Zhanxiang; Jing, Yu; Wang, Shuhong; Gao, Chunji; Yu, Li

    2015-02-01

    Although antithymocyte globulin (ATG) had been widely used in hematopoietic stem cell transplantation from unrelated donor due to its ability to prevent acute and chronic graft-versus-host disease (GVHD), the comparative efficacy and safety of ATG-Thymoglobulin (ATG-T) and ATG-Fresenius (ATG-F) in patients undergoing HLA-mismatched allogeneic peripheral blood stem cell transplantation from unrelated donors (UR-PBSCT) has not been evaluated. Retrospective analysis of patients who underwent HLA-mismatched UR-PBSCT between January 2003 and December 2013 and received pre-transplant ATG-T at a total dose of 10 mg/kg or ATG-F at a total dose of 20 mg/kg was performed. Patients who received ATG-T (n = 23) or ATG-F (n = 28) had similar baseline demographic, disease, and transplant characteristics. There were no significant between-groups differences in the probability of acute GVHD (P = 0.721) and chronic GVHD (P = 0.439). ATG-F was associated with nonsignificant trends toward higher disease-free survival at 3-year follow-up compared with ATG-T (45.7 ± 11.1 vs 61.3 ± 9.7 %, respectively, P = 0.07). A significantly greater proportion of ATG-T patients experienced high fever than ATG-F patients (P F with ATG-T. ATG-T at a total dose of 10 mg/kg and ATG-F at a total dose of 20 mg/kg had a similar clinical outcome in the setting of HLA-mismatched UR-PBSCT.

  9. Three-Axis Model for Atg Recruitment in Autophagy against Salmonella

    Directory of Open Access Journals (Sweden)

    Takeshi Noda

    2012-01-01

    Full Text Available Salmonella enterica serovar Typhimurium enter epithelial cells and take up residence there. Within epithelial cells, a portion of the bacteria are surrounded by an autophagosome-like double-membrane structure, and they are still residing within the Salmonella-containing vacuole (SCV. In this paper, we will discuss how the autophagy machinery is recruited in proximity to Salmonella. The formation of this double membrane requires Atg9L1 and FIP200; these proteins are important for autophagy-specific recruitment of the PI3-kinase complex. In the absence of Atg9L1, FIP200, and PI3-kinase activity, LC3 is still recruited to the vicinity of Salmonella. We propose a novel model in which the mechanism of LC3 recruitment is separate from the generation of the isolation membrane. There exist at least three axes in Atg recruitment: ULK1 complex, Atg9L1, and Atg16L complex.

  10. Current status of nucleonic gauges in Portugal

    International Nuclear Information System (INIS)

    Salgado, J.; Carvalho, F.G.; Manteigas, J.; Oliveira, C.; Goncalves, I.F.; Neves, J.; Cruz, C.

    2000-01-01

    The nucleonic gauges are largely used in Portugal industry, despite the fact that design and manufacturing of prototypes of nucleonic gauges is rather limited. The modernization of some industrial sectors (cement, paper and civil engineering) has enhanced applications of nucleonic gauges and has created local capability but new legislation tends to restrict further spread of them. The Institute of Nuclear Technology is the only applied research institution developing nucleonic gauges for moisture, thickness and density, and elemental analysis, as well as providing assistance in calibration, safe operation and maintenance of them. (author)

  11. ATG7 deficiency suppresses apoptosis and cell death induced by lysosomal photodamage

    Science.gov (United States)

    Kessel, David H.; Price, Michael; Reiners, Jr., John J.

    2012-01-01

    Photodynamic therapy (PDT) involves photosensitizing agents that, in the presence of oxygen and light, initiate formation of cytotoxic reactive oxygen species (ROS). PDT commonly induces both apoptosis and autophagy. Previous studies with murine hepatoma 1c1c7 cells indicated that loss of autophagy-related protein 7 (ATG7) inhibited autophagy and enhanced the cytotoxicity of photosensitizers that mediate photodamage to mitochondria or the endoplasmic reticulum. In this study, we examined two photosensitizing agents that target lysosomes: the chlorin NPe6 and the palladium bacteriopheophorbide WST11. Irradiation of wild-type 1c1c7 cultures loaded with either photosensitizer induced apoptosis and autophagy, with a blockage of autophagic flux. An ATG7- or ATG5-deficiency suppressed the induction of autophagy in PDT protocols using either photosensitizer. Whereas ATG5-deficient cells were quantitatively similar to wild-type cultures in their response to NPe6 and WST11 PDT, an ATG7-deficiency suppressed the apoptotic response (as monitored by analyses of chromatin condensation and procaspase-3/7 activation) and increased the LD50 light dose by > 5-fold (as monitored by colony-forming assays). An ATG7-deficiency did not prevent immediate lysosomal photodamage, as indicated by loss of the lysosomal pH gradient. However, unlike wild-type and ATG5-deficient cells, the lysosomes of ATG7-deficient cells recovered this gradient within 4 h of irradiation, and never underwent permeabilization (monitored as release of endocytosed 10-kDa dextran polymers). We propose that the efficacy of lysosomal photosensitizers is in part due to both promotion of autophagic stress and suppression of autophagic prosurvival functions. In addition, an effect of ATG7 unrelated to autophagy appears to modulate lysosomal photodamage. PMID:22889762

  12. MicroRNA-20a inhibits autophagic process by targeting ATG7 and ATG16L1 and favors mycobacterial survival in macrophage cells.

    Directory of Open Access Journals (Sweden)

    Le Guo

    2016-10-01

    Full Text Available Autophagy plays important roles in the host immune response against mycobacterial infection. Mycobacterium tuberculosis (M. tuberculosis can live in macrophages owing to its ability to evade attacks by regulating autophagic response. MicroRNAs (miRNAs are small noncoding, endogenously encoded RNA which plays critical roles in precise regulation of macrophage functions. Whether miRNAs specifically influence the activation of macrophage autophagy during M. tuberculosis infection are largely unknown. In this study, we demonstrate that BCG infection of macrophages resulted in enhanced expression of miRNA-20a, which inhibits autophagic process by targeting ATG7 and ATG16L1 and promotes BCG survival in macrophages. Forced overexpression of miR-20a decreased the expression levels of LC3-II and the number of LC3 puncta in macrophages, and promoted BCG survival in macrophages, while transfection with miR-20a inhibitor had the opposite effect. Moreover, the inhibitory effect of miR-20a on autophagy was further confimed by transmission electron microscopy (TEM analysis. Quantification of autophagosomes per cellular cross-section revealed a significant reduction upon transfection with miR-20a mimic, but transfection with miR-20a inhibitor increased the number of autophagosomes per cellular cross-section. Moreover, silencing of ATG7 significantly inhibited autophagic response, and transfection with ATG7 siRNA plus miR-20a mimic could further decrease autophagic response. Collectively, our data reveal that miR-20a inhibits autophagic response and promotes BCG survival in macrophages by targeting ATG7 and ATG16L1, which may have implications for a better understanding of pathogenesis of M. tuberculosis infection.

  13. microRNA-20a Inhibits Autophagic Process by Targeting ATG7 and ATG16L1 and Favors Mycobacterial Survival in Macrophage Cells.

    Science.gov (United States)

    Guo, Le; Zhao, Jin; Qu, Yuliang; Yin, Runting; Gao, Qian; Ding, Shuqin; Zhang, Ying; Wei, Jun; Xu, Guangxian

    2016-01-01

    Autophagy plays important roles in the host immune response against mycobacterial infection. Mycobacterium tuberculosis ( M. tuberculosis ) can live in macrophages owing to its ability to evade attacks by regulating autophagic response. MicroRNAs (miRNAs) are small noncoding, endogenously encoded RNA which plays critical roles in precise regulation of macrophage functions. Whether miRNAs specifically influence the activation of macrophage autophagy during M. tuberculosis infection are largely unknown. In this study, we demonstrate that BCG infection of macrophages resulted in enhanced expression of miRNA-20a, which inhibits autophagic process by targeting ATG7 and ATG16L1 and promotes BCG survival in macrophages. Forced overexpression of miR-20a decreased the expression levels of LC3-II and the number of LC3 puncta in macrophages, and promoted BCG survival in macrophages, while transfection with miR-20a inhibitor had the opposite effect. Moreover, the inhibitory effect of miR-20a on autophagy was further confirmed by transmission electron microscopy (TEM) analysis. Quantification of autophagosomes per cellular cross-section revealed a significant reduction upon transfection with miR-20a mimic, but transfection with miR-20a inhibitor increased the number of autophagosomes per cellular cross-section. Moreover, silencing of ATG7 significantly inhibited autophagic response, and transfection with ATG7 siRNA plus miR-20a mimic could further decrease autophagic response. Collectively, our data reveal that miR-20a inhibits autophagic response and promotes BCG survival in macrophages by targeting ATG7 and ATG16L1, which may have implications for a better understanding of pathogenesis of M. tuberculosis infection.

  14. Identification of Atg8 from Acanthamoeba castellanii by genetic complementation in Saccharomyces cerevisiae.

    Science.gov (United States)

    Régnacq, Matthieu; Voisin, Pierre; Héchard, Yann; Bergès, Thierry; Braquart-Varnier, Christine; Samba-Louaka, Ascel

    Autophagy is a eukaryotic process responsible for the degradation of intracellular content such as damaged organelles. Several putative autophagy-related genes have been identified within the annotated genome of the free-living amoeba Acanthamoeba castellanii. However, the involvement of the corresponding proteins in the autophagy pathway had not been formerly established. Here, we report that AcAtg8 cDNA can complement ATG8-deficient Saccharomyces cerevisiae. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Thermistor Pressure Gauge Design

    Science.gov (United States)

    Flanick, A. P.; Ainsworth, J. E.

    1961-01-01

    Thermistor pressure gauges are characterized by large pressure range, good accuracy and stability, fast measurement, insensitivity to over-pressure, negligible out-gassing, ease in cleaning, and physical and electrical simplicity and ruggedness. A number of excellent papers have been published describing these gauges. However, a detailed account of design procedure and characteristics for a specific gauge would eliminate much of the trial and error encountered in designing a gauge having prescribed range, sensitivity, and stability.

  16. Atg9 is required for intraluminal vesicles in amphisomes and autolysosomes

    Directory of Open Access Journals (Sweden)

    C. A. Bader

    2015-11-01

    Full Text Available Autophagy is an intracellular recycling and degradation process, which is important for energy metabolism, lipid metabolism, physiological stress response and organism development. During Drosophila development, autophagy is up-regulated in fat body and midgut cells, to control metabolic function and to enable tissue remodelling. Atg9 is the only transmembrane protein involved in the core autophagy machinery and is thought to have a role in autophagosome formation. During Drosophila development, Atg9 co-located with Atg8 autophagosomes, Rab11 endosomes and Lamp1 endosomes-lysosomes. RNAi silencing of Atg9 reduced both the number and the size of autophagosomes during development and caused morphological changes to amphisomes/autolysosomes. In control cells there was compartmentalised acidification corresponding to intraluminal Rab11/Lamp-1 vesicles, but in Atg9 depleted cells there were no intraluminal vesicles and the acidification was not compartmentalised. We concluded that Atg9 is required to form intraluminal vesicles and for localised acidification within amphisomes/autolysosomes, and consequently when depleted, reduced the capacity to degrade and remodel gut tissue during development.

  17. Abelian gauge theories with tensor gauge fields

    International Nuclear Information System (INIS)

    Kapuscik, E.

    1984-01-01

    Gauge fields of arbitrary tensor type are introduced. In curved space-time the gravitational field serves as a bridge joining different gauge fields. The theory of second order tensor gauge field is developed on the basis of close analogy to Maxwell electrodynamics. The notion of tensor current is introduced and an experimental test of its detection is proposed. The main result consists in a coupled set of field equations representing a generalization of Maxwell theory in which the Einstein equivalence principle is not satisfied. (author)

  18. A barley homolog of yeast ATG6 is involved in multiple abiotic stress responses and stress resistance regulation.

    Science.gov (United States)

    Zeng, Xiaowei; Zeng, Zhanghui; Liu, Cuicui; Yuan, Weiyi; Hou, Ning; Bian, Hongwu; Zhu, Muyuan; Han, Ning

    2017-06-01

    Autophagy is a highly conserved degradation pathway among eukaryote cells, which can recycle damaged or unwanted cell materials upon encountering stress conditions. As a key component of the Class III PI3K kinase complex, ATG6/Beclin-1 is essential for autophagosome formation. In this study, we isolated a putative HvATG6 gene in barley genome. The protein encoded by HvATG6 shares high sequence identity to ATG6 orthologs in rice and wheat, and has a typical autophagy-specific domain containing segments of repeated β-sheet-α-helix. The expression of HvATG6 protein restored the appearance of autophagosomes in yeast atg6 mutant, indicating that HvATG6 complements the deficiency of yeast ATG6 protein in autophagy. Punctate florescence signals, considered as the PAS for autophagosome initiation, were observed in the cytoplasm of cells when HvATG6-GFP fusion construct was transformed into barley protoplast. Furthermore, the expression of HvATG6 was upregulated by various abiotic stresses including dark, H 2 O 2 treatment, nitrogen deficiency, high salinity, drought, low temperature and toxic aluminum. Knockdown of HvATG6 in barley leaves through barley strip mosaic virus (BSMV)-induced gene silencing led to accelerated yellowing under dark and H 2 O 2 treatments. Based on the above findings, we propose that barley ATG6 plays the similar role as other plant ATG6 orthologs, and might be involved in stress-induced autophagy process. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  19. A strain gauge

    DEFF Research Database (Denmark)

    2016-01-01

    The invention relates to a strain gauge of a carrier layer and a meandering measurement grid positioned on the carrier layer, wherein the strain gauge comprises two reinforcement members positioned on the carrier layer at opposite ends of the measurement grid in the axial direction....... The reinforcement members are each placed within a certain axial distance to the measurement grid with the axial distance being equal to or smaller than a factor times the grid spacing. The invention further relates to a multi-axial strain gauge such as a bi-axial strain gauge or a strain gauge rosette where each...... of the strain gauges comprises reinforcement members. The invention further relates to a method for manufacturing a strain gauge as mentioned above....

  20. ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomyces cerevisiae.

    Science.gov (United States)

    López-Martínez, Gema; Margalef-Català, Mar; Salinas, Francisco; Liti, Gianni; Cordero-Otero, Ricardo

    2015-01-01

    Recently, different dehydration-based technologies have been evaluated for the purpose of cell and tissue preservation. Although some early results have been promising, they have not satisfied the requirements for large-scale applications. The long experience of using quantitative trait loci (QTLs) with the yeast Saccharomyces cerevisiae has proven to be a good model organism for studying the link between complex phenotypes and DNA variations. Here, we use QTL analysis as a tool for identifying the specific yeast traits involved in dehydration stress tolerance. Three hybrids obtained from stable haploids and sequenced in the Saccharomyces Genome Resequencing Project showed intermediate dehydration tolerance in most cases. The dehydration resistance trait of 96 segregants from each hybrid was quantified. A smooth, continuous distribution of the anhydrobiosis tolerance trait was found, suggesting that this trait is determined by multiple QTLs. Therefore, we carried out a QTL analysis to identify the determinants of this dehydration tolerance trait at the genomic level. Among the genes identified after reciprocal hemizygosity assays, RSM22, ATG18 and DBR1 had not been referenced in previous studies. We report new phenotypes for these genes using a previously validated test. Finally, our data illustrates the power of this approach in the investigation of the complex cell dehydration phenotype.

  1. Quartz gauge response in ion radiation

    International Nuclear Information System (INIS)

    Taylor, P.E.; Gilbert, P.H.; Kernthaler, C.; Anderson, M.U.

    1995-01-01

    This paper describes recent work to make high quality quartz gauge (temporal and spatial) shock wave measurements in a pulsed ion beam environment. Intense ion beam radiation, nominally 1 MeV protons, was deposited into material samples instrumented with shunted quartz gauges adjacent to the ion deposition zone. Fluence levels were chosen to excite three fundamentally different material response modes (1) strong vapor, (2) combined vapor and melt phase and (3) thermoelastic material response. A unique quartz gauge design was utilized that employed printed circuit board (PCB) technology to facilitate electrical shielding, ruggedness, and fabrication at sign e meeting the essential one dimensional requirements of the characterized Sandia shunted quartz gauge. Shock loading and unloading experiments were conducted to evaluate the piezoelectric response of the coupled quartz gauge/PCB transducer. High fidelity shock wave profiles were recorded at the three ion fluence levels providing dynamic material response data for vapor, melt and solid material phases

  2. Atg7 deficiency impairs host defense against Klebsiella pneumoniae by impacting bacterial clearance, survival and inflammatory responses in mice.

    Science.gov (United States)

    Ye, Yan; Li, Xuefeng; Wang, Wenxue; Ouedraogo, Kiswendsida Claude; Li, Yi; Gan, Changpei; Tan, Shirui; Zhou, Xikun; Wu, Min

    2014-09-01

    Klebsiella pneumoniae (Kp) is a Gram-negative bacterium that can cause serious infections in humans. Autophagy-related gene 7 (Atg7) has been implicated in certain bacterial infections; however, the role of Atg7 in macrophage-mediated immunity against Kp infection has not been elucidated. Here we showed that Atg7 expression was significantly increased in murine alveolar macrophages (MH-S) upon Kp infection, indicating that Atg7 participated in host defense. Knocking down Atg7 with small-interfering RNA increased bacterial burdens in MH-S cells. Using cell biology assays and whole animal imaging analysis, we found that compared with wild-type mice atg7 knockout (KO) mice exhibited increased susceptibility to Kp infection, with decreased survival rates, decreased bacterial clearance, and intensified lung injury. Moreover, Kp infection induced excessive proinflammatory cytokines and superoxide in the lung of atg7 KO mice. Similarly, silencing Atg7 in MH-S cells markedly increased expression levels of proinflammatory cytokines. Collectively, these findings reveal that Atg7 offers critical resistance to Kp infection by modulating both systemic and local production of proinflammatory cytokines. Copyright © 2014 the American Physiological Society.

  3. Gauge symmetry from decoupling

    Directory of Open Access Journals (Sweden)

    C. Wetterich

    2017-02-01

    Full Text Available Gauge symmetries emerge from a redundant description of the effective action for light degrees of freedom after the decoupling of heavy modes. This redundant description avoids the use of explicit constraints in configuration space. For non-linear constraints the gauge symmetries are non-linear. In a quantum field theory setting the gauge symmetries are local and can describe Yang–Mills theories or quantum gravity. We formulate gauge invariant fields that correspond to the non-linear light degrees of freedom. In the context of functional renormalization gauge symmetries can emerge if the flow generates or preserves large mass-like terms for the heavy degrees of freedom. They correspond to a particular form of gauge fixing terms in quantum field theories.

  4. Detecting Genetic Associations between ATG5 and Lupus Nephritis by trans-eQTL

    Directory of Open Access Journals (Sweden)

    Yue-miao Zhang

    2015-01-01

    Full Text Available Objectives. Numerous loci were identified to perturb gene expression in trans. As elevated ATG5 expression was observed in systemic lupus erythematosus (SLE, the study was conducted to analyze the genome-wide genetic regulatory mechanisms associated with ATG5 expression in a Chinese population with lupus nephritis (LN. Methods. The online expression quantitative trait loci database was searched for trans-expression single nucleotide polymorphisms (trans-eSNPs of ATG5. Tagging trans-eSNPs were genotyped by a custom-made genotyping chip in 280 patients and 199 controls. For positive findings, clinical information and bioinformation analyses were performed. Results. Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05, including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1. Correlations between the trans-eSNPs and ATG5 expression and different expression levels of ATG5 in SLE patients and controls were validated, and their regulatory effects were annotated. However, no significant associations were observed between different genotypes of trans-eSNPs and severity or outcome of the patients. Conclusion. Using the new systemic genetics approach, we identified 10 loci associated with susceptibility to LN potentially, which may be complementary to future pathway based genetic studies.

  5. Solution structure of Atg8 reveals conformational polymorphism of the N-terminal domain

    Energy Technology Data Exchange (ETDEWEB)

    Schwarten, Melanie, E-mail: m.schwarten@fz-juelich.de [Institut fuer Strukturbiologie und Biophysik, ISB-3, Forschungszentrum Juelich, 52425 Juelich (Germany); Institut fuer Physikalische Biologie und BMFZ, Heinrich-Heine-Universitaet Duesseldorf, 40225 Duesseldorf (Germany); Stoldt, Matthias, E-mail: m.stoldt@fz-juelich.de [Institut fuer Strukturbiologie und Biophysik, ISB-3, Forschungszentrum Juelich, 52425 Juelich (Germany); Institut fuer Physikalische Biologie und BMFZ, Heinrich-Heine-Universitaet Duesseldorf, 40225 Duesseldorf (Germany); Mohrlueder, Jeannine, E-mail: j.mohrlueder@fz-juelich.de [Institut fuer Strukturbiologie und Biophysik, ISB-3, Forschungszentrum Juelich, 52425 Juelich (Germany); Willbold, Dieter, E-mail: dieter.willbold@uni-duesseldorf.de [Institut fuer Strukturbiologie und Biophysik, ISB-3, Forschungszentrum Juelich, 52425 Juelich (Germany); Institut fuer Physikalische Biologie und BMFZ, Heinrich-Heine-Universitaet Duesseldorf, 40225 Duesseldorf (Germany)

    2010-05-07

    During autophagy a crescent shaped like membrane is formed, which engulfs the material that is to be degraded. This membrane grows further until its edges fuse to form the double membrane covered autophagosome. Atg8 is a protein, which is required for this initial step of autophagy. Therefore, a multistage conjugation process of newly synthesized Atg8 to phosphatidylethanolamine is of critical importance. Here we present the high resolution structure of unprocessed Atg8 determined by nuclear magnetic resonance spectroscopy. Its C-terminal subdomain shows a well-defined ubiquitin-like fold with slightly elevated mobility in the pico- to nanosecond timescale as determined by heteronuclear NOE data. In comparison to unprocessed Atg8, cleaved Atg8{sup G116} shows a decreased mobility behaviour. The N-terminal domain adopts different conformations within the micro- to millisecond timescale. The possible biological relevance of the differences in dynamic behaviours between both subdomains as well as between the cleaved and uncleaved forms is discussed.

  6. Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis

    Science.gov (United States)

    Cabrera, Sandra; Maciel, Mariana; Herrera, Iliana; Nava, Teresa; Vergara, Fabián; Gaxiola, Miguel; López-Otín, Carlos; Selman, Moisés; Pardo, Annie

    2015-01-01

    Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and proteins. Impaired autophagic activity is involved in a number of diseases, including idiopathic pulmonary fibrosis suggesting that altered autophagy may contribute to fibrogenesis. However, the specific role of autophagy in lung fibrosis is still undefined. In this study, we show for the first time, how autophagy disruption contributes to bleomycin-induced lung fibrosis in vivo using an Atg4b-deficient mouse as a model. Atg4b-deficient mice displayed a significantly higher inflammatory response at 7 d after bleomycin treatment associated with increased neutrophilic infiltration and significant alterations in proinflammatory cytokines. Likewise, we found that Atg4b disruption resulted in augmented apoptosis affecting predominantly alveolar and bronchiolar epithelial cells. At 28 d post-bleomycin instillation Atg4b-deficient mice exhibited more extensive and severe fibrosis with increased collagen accumulation and deregulated extracellular matrix-related gene expression. Together, our findings indicate that the ATG4B protease and autophagy play a crucial role protecting epithelial cells against bleomycin-induced stress and apoptosis, and in the regulation of the inflammatory and fibrotic responses. PMID:25906080

  7. An octonionic gauge theory

    International Nuclear Information System (INIS)

    Lassig, C.C.; Joshi, G.C.

    1995-01-01

    The nonassociativity of the octonion algebra makes necessitates a bimodule representation, in which each element is represented by a left and a right multiplier. This representation can then be used to generate gauge transformations for the purpose of constructing a field theory symmetric under a gauged octonion algebra, the nonassociativity of which appears as a failure of the representation to close, and hence produces new interactions in the gauge field kinetic term of the symmetric Lagrangian. 5 refs., 1 tab

  8. High temperature pressure gauge

    Science.gov (United States)

    Echtler, J. Paul; Scandrol, Roy O.

    1981-01-01

    A high temperature pressure gauge comprising a pressure gauge positioned in fluid communication with one end of a conduit which has a diaphragm mounted in its other end. The conduit is filled with a low melting metal alloy above the diaphragm for a portion of its length with a high temperature fluid being positioned in the remaining length of the conduit and in the pressure gauge.

  9. Introduction to gauge theories

    International Nuclear Information System (INIS)

    Okun, L.B.

    1984-01-01

    These lecture notes contain the text of five lectures and a Supplement. The lectures were given at the JINR-CERN School of Physics, Tabor, Czechoslovakia, 5-18 June 1983. The subgect of the lecinvariancetures: gauge of electromagnetic and weak interactions, higgs and supersymmetric particles. The Supplement contains reprints (or excerpts) of some classical papers on gauge invariance by V. Fock, F. London, O. Klein and H. Weyl, in which the concept of gauge invariance was introduced and developed

  10. Nonlocal gauge theories

    International Nuclear Information System (INIS)

    Partovi, M.H.

    1982-01-01

    From a generalization of the covariant derivative, nonlocal gauge theories are developed. These theories enjoy local gauge invariance and associated Ward identities, a corresponding locally conserved current, and a locally conserved energy-momentum tensor, with the Ward identities implying the masslessness of the gauge field as in local theories. Their ultraviolet behavior allows the presence as well as the absence of the Adler-Bell-Jackiw anomaly, the latter in analogy with lattice theories

  11. Gauge freedom in path integrals in Abelian gauge theory

    OpenAIRE

    Saito, Teijiro; Endo, Ryusuke; Miura, Hikaru

    2016-01-01

    We extend the gauge symmetry of an Abelian gauge field to incorporate quantum gauge degrees of freedom. We twice apply the Harada–Tsutsui gauge recovery procedure to gauge-fixed theories. First, starting from the Faddeev–Popov path integral in the Landau gauge, we recover the gauge symmetry by introducing an additional field as an extended gauge degree of freedom. Fixing the extended gauge symmetry by the usual Faddeev–Popov procedure, we obtain the theory of Type I gaugeon formalism. Next, a...

  12. Parastatistics and gauge symmetries

    International Nuclear Information System (INIS)

    Govorkov, A.B.

    1982-01-01

    A possible formulation of gauge symmetries in the Green parafield theory is analysed and the SO(3) gauge symmetry is shown to be on a distinct status. The Greenberg paraquark hypothesis turns out to be not equivalent to the hypothesis of quark colour SU(3)sub(c) symmetry. Specific features of the gauge SO(3) symmetry are discussed, and a possible scheme where it is an exact subgroup of the broken SU(3)sub(c) symmetry is proposed. The direct formulation of the gauge principle for the parafield represented by quaternions is also discussed

  13. Implementing general gauge mediation

    International Nuclear Information System (INIS)

    Carpenter, Linda M.; Dine, Michael; Festuccia, Guido; Mason, John D.

    2009-01-01

    Recently there has been much progress in building models of gauge mediation, often with predictions different than those of minimal gauge mediation. Meade, Seiberg, and Shih have characterized the most general spectrum which can arise in gauge-mediated models. We discuss some of the challenges of building models of general gauge mediation, especially the problem of messenger parity and issues connected with R symmetry breaking and CP violation. We build a variety of viable, weakly coupled models which exhibit some or all of the possible low energy parameters.

  14. A new gauge for supersymmetric abelian gauge theories

    International Nuclear Information System (INIS)

    Smith, A.W.; Barcelos Neto, J.

    1984-01-01

    A new gauge for supersymmetric abelian gauge theories is presented. It is shown that this new gauge allows us to obtain terms which usually come as radiative corrections to the supersymmetric abelian gauge theories when one uses the Wess-Zumino gauge. (Author) [pt

  15. The current status of nucleonic gauge activity in China

    International Nuclear Information System (INIS)

    Liye Zhou

    2000-01-01

    The nucleonic gauge technology in China is in full development. The nucleonic gauges are widely used, mainly in metallurgy, coal, cement and rubber industries. The simple first generation of nucleonic gauge is locally designed and manufactured in industrial scale by many institutions and enterprises. The local market is large and far from being saturated. The quality and reliability of nucleonic gauges and their integration into the control system are still concern. Research and development is going on to improve the quality and to design and produce second generation of multibeam and multienergy nucleonic gauges. (author)

  16. Targeted deletion of Atg5 reveals differential roles of autophagy in keratin K5-expressing epithelia

    Energy Technology Data Exchange (ETDEWEB)

    Sukseree, Supawadee [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria); Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok (Thailand); Rossiter, Heidemarie; Mildner, Michael [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria); Pammer, Johannes [Institute of Clinical Pathology, Medical University of Vienna, Vienna (Austria); Buchberger, Maria; Gruber, Florian [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria); Watanapokasin, Ramida [Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok (Thailand); Tschachler, Erwin [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria); Eckhart, Leopold, E-mail: leopold.eckhart@meduniwien.ac.at [Research Division of Biology and Pathobiology of the Skin, Department of Dermatology, Medical University of Vienna, Vienna (Austria)

    2013-01-11

    Highlights: Black-Right-Pointing-Pointer We generated mice lacking Atg5 and autophagy in keratin K5-positive epithelia. Black-Right-Pointing-Pointer Suppression of autophagy in thymic epithelium was not associated with signs of autoimmunity. Black-Right-Pointing-Pointer Autophagy was required for normal terminal differentiation of preputial gland cells. Black-Right-Pointing-Pointer Autophagy-deficient cells of the preputial glands degraded nuclear DNA prematurely. -- Abstract: Autophagy contributes to the homeostasis of many tissues, yet its role in epithelia is incompletely understood. A recent report proposed that Atg5-dependent autophagy in thymic epithelial cells is essential for their function in the negative selection of self-reactive T-cells and, thus, for the suppression of tissue inflammation. Here we crossed mice carrying floxed alleles of the Atg5 gene with mice expressing the Cre recombinase under the control of the keratin K5 promoter to suppress autophagy in all K5-positive epithelia. The efficiency of autophagy abrogation was confirmed by immunoanalyses of LC3, which was converted to the autophagy-associated LC3-II form in normal but not Atg5-deficient cells, and of p62, which accumulated in Atg5-deficient cells. Mice carrying the epithelium-specific deletion of Atg5 showed normal weight gain, absence of tissue inflammation, and a normal morphology of the thymic epithelium. By contrast, autophagy-deficient epithelial cells of the preputial gland showed aberrant eosinophilic staining in histology and premature degradation of nuclear DNA during terminal differentiation. Taken together, the results of this study suggest that autophagy is dispensable for the suppression of autoimmunity by thymic epithelial cells but essential for normal differentiation of the preputial gland in mice.

  17. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3

    Science.gov (United States)

    Murthy, Aditya; Li, Yun; Peng, Ivan; Reichelt, Mike; Katakam, Anand Kumar; Noubade, Rajkumar; Roose-Girma, Merone; Devoss, Jason; Diehl, Lauri; Graham, Robert R.; van Lookeren Campagne, Menno

    2014-02-01

    Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associated with the incidence of Crohn's disease. Numerous studies have demonstrated the effect of ATG16L1 deletion or deficiency; however, the molecular consequences of the Thr300Ala (T300A) variant remains unknown. Here we show that amino acids 296-299 constitute a caspase cleavage motif in ATG16L1 and that the T300A variant (T316A in mice) significantly increases ATG16L1 sensitization to caspase-3-mediated processing. We observed that death-receptor activation or starvation-induced metabolic stress in human and murine macrophages increased degradation of the T300A or T316A variants of ATG16L1, respectively, resulting in diminished autophagy. Knock-in mice harbouring the T316A variant showed defective clearance of the ileal pathogen Yersinia enterocolitica and an elevated inflammatory cytokine response. In turn, deletion of the caspase-3-encoding gene, Casp3, or elimination of the caspase cleavage site by site-directed mutagenesis rescued starvation-induced autophagy and pathogen clearance, respectively. These findings demonstrate that caspase 3 activation in the presence of a common risk allele leads to accelerated degradation of ATG16L1, placing cellular stress, apoptotic stimuli and impaired autophagy in a unified pathway that predisposes to Crohn's disease.

  18. ATG and the impact of heating line optimization. Adaptive temperature boundary values in practice; ATG en de invloed van stooklijn optirnalisatie. Adaptieve temperatuur grenswaarden in de praktijk

    Energy Technology Data Exchange (ETDEWEB)

    Van Dam, P.; Plokker, W. [Vereniging voor Automatisering in de Bouw en Installatietechniek VABI, Delft (Netherlands)

    2006-05-15

    With the introduction of the ISSO-publication no. 74 (Thermal comfort, Requirements for the indoor temperature in buildings) it is possible to simulate and test the design of an installation. In particular in relation to the optimal heating and cooling lines. This also improves the communication between the designer and the ATG-method (adaptive temperature boundary values) [Dutch] Met de introductie van Isso-publicatie 74 'Thermische behaaglijkheid, eisen voor de binnenternperatuur in gebouwen' is er een mogelijkheid ontstaan om het installatieontwerp te kunnen simuleren en toetsen. Vooral in de relatie tot de instelling van de optimale stook- en koellijnen Dit verhoogt de comrnunicatie naar de ontwerper en de ATG-methode (Adaptieve temperatuur grenswaarden)

  19. Chiral gauge theories on the lattice with exact gauge invariance

    OpenAIRE

    Lüscher, Martin

    1999-01-01

    A recently proposed formulation of chiral lattice gauge theories is reviewed, in which the locality and gauge invariance of the theory can be preserved if the fermion representation of the gauge group is anomaly-free.

  20. Non-abelian gauge fields in the Poincare gauge

    International Nuclear Information System (INIS)

    Galvao, C.A.P.; Pimentel, B.M.

    1988-01-01

    The canonical structure of non-Abelian gauge fields is analysed in the (non-covariant) Poincare gauge. General aspects of the gauge conditions and quantization prescriptions are discussed. (author) [pt

  1. 27-Gauge vitrectomy.

    Science.gov (United States)

    Osawa, Shunsuke; Oshima, Yusuke

    2014-01-01

    Ten years or more have passed since the current concept of 25-gauge transconjunctival sutureless vitrectomy with a trocar-cannula system emerged. There is no doubt that current microincision vitrectomy surgery with 25- or 23-gauge instrumentation has simplified the vitrectomy procedure and has provided numerous potential advantages over traditional 20-gauge surgery. The established theory regarding surgical wounds is that 'much smaller is better'. Along with the development of new-generation vitrectomy machines with ergonomic instruments, surgeons have been shifting dramatically from 20-gauge systems to 23- and 25-gauge systems over the last years. Thanks to recent innovations and improvements in high-end multifunctional vitrectomy machines and ultrahigh-speed cutters, the development of powerful light sources, and wide-angle viewing systems, several new techniques have also encouraged us to launch the development of a 27-gauge vitrectomy system over the past several years. Similar to the recent evolution in 23- and 25-gauge systems, further development and refinement of the functionality of instruments with a gauge of 27 or more are under way and will continue over the coming years, which in the future will allow us to establish this system for ultra-minimally invasive surgery for the full spectrum of vitreoretinal pathologies. © 2014 S. Karger AG, Basel.

  2. A strain gauge

    DEFF Research Database (Denmark)

    2017-01-01

    The invention relates to a strain gauge of a carrier layer and a meandering measurement grid (101) positioned on the carrier layer, wherein the measurement grid comprises a number of measurement grid sections placed side by side with gaps in between, and a number of end loops (106) interconnecting...... relates to a method for manufacturing a strain gauge as mentioned above....

  3. Rain Gauges Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Bartholomew, M. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-01-01

    To improve the quantitative description of precipitation processes in climate models, the Atmospheric Radiation Measurement (ARM) Climate Research Facility deployed rain gauges located near disdrometers (DISD and VDIS data streams). This handbook deals specifically with the rain gauges that make the observations for the RAIN data stream. Other precipitation observations are made by the surface meteorology instrument suite (i.e., MET data stream).

  4. The Relationship of the Laplacian Gauge to the Landau Gauge

    OpenAIRE

    Mandula, Jeffrey E.

    2001-01-01

    The Laplacian gauge for gauge group SU(N) is discussed in perturbation theory. It is shown that to the lowest non-trivial order, O(g^1), configurations in the Laplacian gauge automatically satisfy the (finite difference) Landau gauge condition. Laplacian gauge fixed configurations are examined numerically and it is seen that to O(g^2) they do not remain in the Landau gauge.

  5. Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1.

    Directory of Open Access Journals (Sweden)

    Akter Mst Yeasmin

    Full Text Available Target of rapamycin complex 1 (TORC1 phosphorylates autophagy-related Atg13 and represses autophagy under nutrient-rich conditions. However, when TORC1 becomes inactive upon nutrient depletion or treatment with the TORC1 inhibitor rapamycin, Atg13 dephosphorylation occurs rapidly, and autophagy is induced. At present, the phosphatases involved in Atg13 dephosphorylation remain unknown. Here, we show that two protein phosphatase 2A (PP2A phosphatases, PP2A-Cdc55 and PP2A-Rts1, which are activated by inactivation of TORC1, are required for sufficient Atg13 dephosphorylation and autophagy induction after TORC1 inactivation in budding yeast. After rapamycin treatment, dephosphorylation of Atg13, activation of Atg1 kinase, pre-autophagosomal structure (PAS formation and autophagy induction are all impaired in PP2A-deleted cells. Conversely, overexpression of non-phosphorylatable Atg13 suppressed defects in autophagy in PP2A mutant. This study revealed that the orchestrated action of PP2A antagonizes Atg13 phosphorylation and promotes autophagy after the inactivation of TORC1.

  6. Twisted Gauge Theories

    Science.gov (United States)

    Aschieri, Paolo; Dimitrijević, Marija; Meyer, Frank; Schraml, Stefan; Wess, Julius

    2006-10-01

    Gauge theories on a space-time that is deformed by the Moyal-Weyl product are constructed by twisting the coproduct for gauge transformations. This way a deformed Leibniz rule is obtained, which is used to construct gauge invariant quantities. The connection will be enveloping algebra valued in a particular representation of the Lie algebra. This gives rise to additional fields, which couple only weakly via the deformation parameter θ and reduce in the commutative limit to free fields. Consistent field equations that lead to conservation laws are derived and some properties of such theories are discussed.

  7. Precision contact level gauge

    International Nuclear Information System (INIS)

    Krejci, M.; Pilat, M.; Stulik, P.

    1977-01-01

    Equipment was developed measuring the heavy water level in the TR-0 reactor core within an accuracy of several hundredths of a millimeter in a range of around 3.5 m and at a temperature of up to 90 degC. The equipment uses a vibrating needle contact as a high sensitivity level gauge and a servomechanical system with a motion screw carrying the gauge for monitoring and measuring the level in the desired range. The advantage of the unique level gauge consists in that that the transducer converts the measured level position to an electric signal, ie., pulse width, with high sensitivity and without hysteresis. (Kr)

  8. Microcomputerized neutron moisture gauge

    International Nuclear Information System (INIS)

    Liu Shengkang; Mei Yu

    1987-01-01

    A microcomputerized neutron moisture gauge is introduced. This gauge consists of a neutron moisture sensor and instruments. It is developed from the neutron moisture gauge for concrete mixer. A TECH-81 single card microcomputer is used for count, computation and display. It has the function of computing compensated quantity of sand. It can acquire the data from several neutron sensors by the multichanneling sampling, therefore it can measure moisture values of sand in several hoppers simultaneously. The precision of the static state calibration curve is 0.24% wt. The error limits of the dynamic state check is < 0.50% wt

  9. Hot Conformal Gauge Theories

    DEFF Research Database (Denmark)

    Mojaza, Matin; Pica, Claudio; Sannino, Francesco

    2010-01-01

    We compute the nonzero temperature free energy up to the order g^6 \\ln(1/g) in the coupling constant for vector like SU(N) gauge theories featuring matter transforming according to different representations of the underlying gauge group. The number of matter fields, i.e. flavors, is arranged...... of flavors. Surprisingly this number, if computed to the order g^2, agrees with previous predictions for the lower boundary of the conformal window for nonsupersymmetric gauge theories. The higher order results tend to predict a higher number of critical flavors. These are universal properties, i...

  10. Rod examination gauge

    Energy Technology Data Exchange (ETDEWEB)

    Bacvinskas, W.S.; Bayer, J.E.; Davis, W.W.; Fodor, G.; Kikta, T.J.; Matchett, R.L.; Nilsen, R.J.; Wilczynski, R.

    1991-12-31

    The present invention is directed to a semi-automatic rod examination gauge for performing a large number of exacting measurements on radioactive fuel rods. The rod examination gauge performs various measurements underwater with remote controlled machinery of high reliability. The rod examination gauge includes instruments and a closed circuit television camera for measuring fuel rod length, free hanging bow measurement, diameter measurement, oxide thickness measurement, cladding defect examination, rod ovality measurement, wear mark depth and volume measurement, as well as visual examination. A control system is provided including a programmable logic controller and a computer for providing a programmed sequence of operations for the rod examination and collection of data.

  11. General gauge mediation

    International Nuclear Information System (INIS)

    Meade, Patrick; Seiberg, Nathan; Shih, David

    2009-01-01

    We give a general definition of gauge mediated supersymmetry breaking which encompasses all the known gauge mediation models. In particular, it includes both models with messengers as well as direct mediation models. A formalism for computing the soft terms in the generic model is presented. Such a formalism is necessary in strongly-coupled direct mediation models where perturbation theory cannot be used. It allows us to identify features of the entire class of gauge mediation models and to distinguish them from specific signatures of various subclasses. (author)

  12. Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin

    Directory of Open Access Journals (Sweden)

    Elena Marcassa

    2017-05-01

    Full Text Available CAPNS1 is essential for stability and function of the ubiquitous calcium-dependent proteases micro- and milli-calpain. Upon inhibition of the endoplasmic reticulum Ca2+ ATPase by 100 nM thapsigargin, both micro-calpain and autophagy are activated in human U2OS osteosarcoma cells in a CAPNS1-dependent manner. As reported for other autophagy triggers, thapsigargin treatment induces Golgi fragmentation and fusion of Atg9/Bif-1-containing vesicles with LC3 bodies in control cells. By contrast, CAPNS1 depletion is coupled with an accumulation of LC3 bodies and Rab5 early endosomes. Moreover, Atg9 and Bif-1 remain in the GM130-positive Golgi stacks and Atg9 fails to interact with the endocytic route marker transferrin receptor and with the core autophagic protein Vps34 in CAPNS1-depleted cells. Ectopic expression of a Bif-1 point mutant resistant to calpain processing is coupled to endogenous p62 and LC3-II accumulation. Altogether, these data indicate that calpain allows dynamic flux of Atg9/Bif-1 vesicles from the Golgi toward the budding autophagosome.

  13. Gauge field copies

    International Nuclear Information System (INIS)

    Bollini, C.G.; Giambiagi, J.J.; Tiomno, J.

    1979-01-01

    The construction of field strength copies without any gauge constraint is discussed. Several examples are given, one of which is not only a field strength copy but also (at the same time) a 'current copy'. (author) [pt

  14. Gauge theories and monopoles

    International Nuclear Information System (INIS)

    Cabibbo, N.

    1983-01-01

    This chapter attempts to present some of the fundamental geometrical ideas at the basis of gauge theories. Describes Dirac Monopoles and discusses those ideas that are not usually found in more ''utilitarian'' presentations which concentrate on QCD or on the Glashow-Salam-Weinberg model. This topic was chosen because of the announcement of the possible detection of a Dirac monopole. The existence of monopoles depends on topological features of gauge theories (i.e., on global properties of field configurations which are unique to gauge theories). Discusses global symmetry-local symmetry; the connection; path dependence and the gauge fields; topology and monopoles; the case of SU(3) x U(1); and the 't Hooft-Polyakov monopole

  15. Amorphous gauge glass theory

    International Nuclear Information System (INIS)

    Nielsen, H.B.; Bennett, D.L.

    1987-08-01

    Assuming that a lattice gauge theory describes a fundamental attribute of Nature, it should be pointed out that such a theory in the form of a gauge glass is a weaker assumption than a regular lattice model in as much as it is not constrained by the imposition of translational invariance; translational invariance is, however, recovered approximately in the long wavelength or continuum limit. (orig./WL)

  16. Viscous conformal gauge theories

    DEFF Research Database (Denmark)

    Toniato, Arianna; Sannino, Francesco; Rischke, Dirk H.

    2017-01-01

    We present the conformal behavior of the shear viscosity-to-entropy density ratio and the fermion-number diffusion coefficient within the perturbative regime of the conformal window for gauge-fermion theories.......We present the conformal behavior of the shear viscosity-to-entropy density ratio and the fermion-number diffusion coefficient within the perturbative regime of the conformal window for gauge-fermion theories....

  17. Gauge engineering and propagators

    Directory of Open Access Journals (Sweden)

    Maas Axel

    2017-01-01

    The dependence of the propagators on the choice of these complete gauge-fixings will then be investigated using lattice gauge theory for Yang-Mills theory. It is found that the implications for the infrared, and to some extent mid-momentum behavior, can be substantial. In going beyond the Yang-Mills case it turns out that the influence of matter can generally not be neglected. This will be briefly discussed for various types of matter.

  18. Quantum and classical gauge symmetries

    International Nuclear Information System (INIS)

    Fujikawa, Kazuo; Terashima, Hiroaki

    2001-01-01

    The use of the mass term of the gauge field as a gauge fixing term, which was discussed by Zwanziger, Parrinello and Jona-Lasinio in a large mass limit, is related to the non-linear gauge by Dirac and Nambu. We have recently shown that this use of the mass term as a gauge fixing term is in fact identical to the conventional local Faddeev-Popov formula without taking a large mass limit, if one takes into account the variation of the gauge field along the entire gauge orbit. This suggests that the classical massive vector theory, for example, could be re-interpreted as a gauge invariant theory with a gauge fixing term added in suitably quantized theory. As for massive gauge particles, the Higgs mechanics, where the mass term is gauge invariant, has a more intrinsic meaning. We comment on several implications of this observation. (author)

  19. Upregulation of autophagy-related gene-5 (ATG-5 is associated with chemoresistance in human gastric cancer.

    Directory of Open Access Journals (Sweden)

    Jie Ge

    Full Text Available Autophagy-related gene-5 (ATG-5 is one of the key regulators of autophagic cell death. It has been widely regarded as a protective molecular mechanism for tumor cells during the course of chemotherapy. In the present study, we investigated the expression pattern of ATG-5 and multidrug resistance-associated protein-1 (MRP-1 in 135 gastric cancers (GC patients who were treated with epirubicin, cisplatin and 5-FU adjuvant chemotherapy (ECF following surgical resection and explored their potential clinical significance. We found that both ATG-5 (77.78% and MRP-1 (79.26% were highly expressed in GC patients. ATG-5 expression was significantly associated with depth of wall invasion, TNM stages and distant metastasis of GC (P<0.05, whereas MRP-1 expression was significantly linked with tumor size, depth of wall invasion, lymph node metastasis, TNM stages and differentiation status (P<0.05. ATG-5 expression was positively correlated with MRP-1 (rp = 0.616, P<0.01. Increased expression of ATG-5 and MPR-1 was significantly correlated with poor overall survival (OS; P<0.01 and disease free survival (DFS; P<0.01 of our GC cohort. Furthermore, we demonstrated that ATG-5 was involved in drug resistant of GC cells, which was mainly through regulating autophagy. Our data suggest that upregulated expression of ATG-5, an important molecular feature of protective autophagy, is associated with chemoresistance in GC. Expression of ATG-5 and MRP-1 may be independent prognostic markers for GC treatment.

  20. Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation.

    Science.gov (United States)

    Admiraal, Rick; Lindemans, Caroline A; van Kesteren, Charlotte; Bierings, Marc B; Versluijs, A Birgitta; Nierkens, Stefan; Boelens, Jaap Jan

    2016-12-08

    Successful immune reconstitution (IR) is associated with improved outcomes following pediatric cord blood transplantation (CBT). Usage and timing of anti-thymocyte globulin (ATG), introduced to the conditioning to prevent graft-versus-host disease and graft failure, negatively influences T-cell IR. We studied the relationships among ATG exposure, IR, and clinical outcomes. All pediatric patients receiving a first CBT between 2004 and 2015 at the University Medical Center Utrecht were included. ATG-exposure measures were determined with a validated pharmacokinetics model. Main outcome of interest was early CD4 + IR, defined as CD4 + T-cell counts >50 × 10 6 /L twice within 100 days after CBT. Other outcomes of interest included event-free survival (EFS). Cox proportional-hazard and Fine-Gray competing-risk models were used. A total of 137 patients, with a median age of 7.4 years (range, 0.2-22.7), were included, of whom 82% received ATG. Area under the curve (AUC) of ATG after infusion of the cord blood transplant predicted successful CD4 + IR. Adjusted probability on CD4 + IR was reduced by 26% for every 10-point increase in AUC after CBT (hazard ratio [HR], 0.974; P < .0001). The chance of EFS was higher in patients with successful CD4 + IR (HR, 0.26; P < .0001) and lower ATG exposure after CBT (HR, 1.005; P = .0071). This study stresses the importance of early CD4 + IR after CBT, which can be achieved by reducing the exposure to ATG after CBT. Individualized dosing of ATG to reach optimal exposure or, in selected patients, omission of ATG may contribute to improved outcomes in pediatric CBT. © 2016 by The American Society of Hematology.

  1. Non-Abelian gauge fields

    Science.gov (United States)

    Gerbier, Fabrice; Goldman, Nathan; Lewenstein, Maciej; Sengstock, Klaus

    2013-07-01

    Building a universal quantum computer is a central goal of emerging quantum technologies, which has the potential to revolutionize science and technology. Unfortunately, this future does not seem to be very close at hand. However, quantum computers built for a special purpose, i.e. quantum simulators , are currently developed in many leading laboratories. Many schemes for quantum simulation have been proposed and realized using, e.g., ultracold atoms in optical lattices, ultracold trapped ions, atoms in arrays of cavities, atoms/ions in arrays of traps, quantum dots, photonic networks, or superconducting circuits. The progress in experimental implementations is more than spectacular. Particularly interesting are those systems that simulate quantum matter evolving in the presence of gauge fields. In the quantum simulation framework, the generated (synthetic) gauge fields may be Abelian, in which case they are the direct analogues of the vector potentials commonly associated with magnetic fields. In condensed matter physics, strong magnetic fields lead to a plethora of fascinating phenomena, among which the most paradigmatic is perhaps the quantum Hall effect. The standard Hall effect consists in the appearance of a transverse current, when a longitudinal voltage difference is applied to a conducting sample. For quasi-two-dimensional semiconductors at low temperatures placed in very strong magnetic fields, the transverse conductivity, the ratio between the transverse current and the applied voltage, exhibits perfect and robust quantization, independent for instance of the material or of its geometry. Such an integer quantum Hall effect, is now understood as a deep consequence of underlying topological order. Although such a system is an insulator in the bulk, it supports topologically robust edge excitations which carry the Hall current. The robustness of these chiral excitations against backscattering explains the universality of the quantum Hall effect. Another

  2. Atg12 Maintains Skeletal Integrity by Modulating Pro-Osteoclastogenic Signals and Chondrocyte Differentiation

    Science.gov (United States)

    Tahimic, Candice; Bahl, Disha; Shirazi-Fard, Yasaman; Marsh, Timothy; Schreurs, Anne-Sofie; Rael, Victoria E.; Glikbarg, Chloe; Debnath, Jayantha; Globus, Ruth K.

    2016-01-01

    Weightlessness and radiation, two unique elements of space, profoundly decreases bone mass. This bone loss is attributed to increased activity of bone-resorbing osteoclasts and functional changes in bone-forming osteoblasts, cells that give rise to mature osteocytes. Our long-term goal is to identify signaling pathways that may be targeted to mitigate bone loss in scenarios of space exploration, radiotherapy and accidental radiation exposure. We have previously shown that exposure of MLO-Y4 osteocyte-like cells to simulated space radiation (56Fe) increased the expression of the pro-osteoclastogenic gene rankl and decreased protein levels of LC3B-II, a key player in autophagy. In this current study, we aimed to further elucidate the role of autophagy in maintaining structural integrity of the skeleton. We hypothesize that loss of autophagy in bone leads to an imbalance in pro-osteoclastogenic and pro-osteogenic signals, resulting in net bone loss. To test our hypothesis we performed global postnatal deletion of Atg12 using tamoxifeninducible Cre recombinase under the control of the CAG promoter. Six-week-old CAGCreERT2/ FloxAtg12 animals were treated daily with Tamoxifen or Vehicle (Control, oil only) for five days and euthanasia performed two weeks after the onset of treatment. Percent change in body weights (prior to treatment and at euthanasia) was not significantly different between treatment groups within the same gender. Compared to Vehicle (Control) groups, Tamoxifen (Atg12 iKO) groups showed decreased LC3B-I to II conversion and increased p62 protein levels, consistent with loss of autophagy. Quantitative PCR revealed increased expression of proosteoclastogenic cytokines mcp1 and rankl in bone and marrow respectively in male iKOs compared to male controls. Expression levels of these genes were not significantly altered in the Atg12 iKO females compared to females controls. Microcomputed tomography of tibiae revealed decreased cortical bone volume, cortical

  3. Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy.

    Science.gov (United States)

    Hamer, Isabelle; Goffin, Emeline; De Bolle, Xavier; Letesson, Jean-Jacques; Jadot, Michel

    2014-09-02

    Several intracellular bacterial pathogens have evolved subtle strategies to subvert vesicular trafficking pathways of their host cells to avoid killing and to replicate inside the cells. Brucellae are Gram-negative facultative intracellular bacteria that are responsible for brucellosis, a worldwide extended chronic zoonosis. Following invasion, Brucella abortus is found in a vacuole that interacts first with various endosomal compartments and then with endoplasmic reticulum sub-compartments. Brucella establishes its replication niche in ER-derived vesicles. In the past, it has been proposed that B. abortus passed through the macroautophagy pathway before reaching its niche of replication. However, recent experiments provided evidence that the classical macroautophagy pathway was not involved in the intracellular trafficking and the replication of B. abortus in bone marrow-derived macrophages and in HeLa cells. In contrast, another study showed that macroautophagy favoured the survival and the replication of Brucella melitensis in infected RAW264.7 macrophages. This raises the possibility that B. abortus and B. melitensis followed different intracellular pathways before replicating. In the present work, we have addressed this issue by comparing the replication rate of B. abortus and B. melitensis in embryonic fibroblasts derived from wild-type and Atg5-/- mice, Atg5 being a core component of the canonical macroautophagic pathway. Our results indicate that both B. abortus S2308 and B. melitensis 16M strains are able to invade and replicate in Atg5-deficient fibroblasts, suggesting that the canonical Atg5-dependent macroautophagic pathway is dispensable for Brucella replication. The number of viable bacteria was even slightly higher in Atg5-/- fibroblasts than in wild-type fibroblasts. This increase could be due to a more efficient uptake or to a better survival rate of bacteria before the beginning of the replication in Atg5-deficient cells as compared to wild

  4. Renormalizable Non-Covariant Gauges and Coulomb Gauge Limit

    CERN Document Server

    Baulieu, L

    1999-01-01

    To study ``physical'' gauges such as the Coulomb, light-cone, axial or temporal gauge, we consider ``interpolating'' gauges which interpolate linearly between a covariant gauge, such as the Feynman or Landau gauge, and a physical gauge. Lorentz breaking by the gauge-fixing term of interpolating gauges is controlled by extending the BRST method to include not only the local gauge group, but also the global Lorentz group. We enumerate the possible divergences of interpolating gauges, and show that they are renormalizable, and we show that the expectation value of physical observables is the same as in a covariant gauge. In the second part of the article we study the Coulomb-gauge as the singular limit of the Landau-Coulomb interpolating gauge. We find that unrenormalized and renormalized correlation functions are finite in this limit. We also find that there are finite two-loop diagrams of ``unphysical'' particles that are not present in formal canonical quantization in the Coulomb gauge. We verify that in the ...

  5. Identification, molecular cloning and expression analysis of a HORMA domain containing Autophagy-related gene 13 (ATG13 from the coleopteran beetle, Tenebrio molitor

    Directory of Open Access Journals (Sweden)

    Jung Hee eLee

    2015-06-01

    Full Text Available Autophagy is a process that is necessary during starvation as it replenishes metabolic precursors by eliminating damaged organelles. Autophagy is mediated by more than 35 autophagy-related (Atg proteins that manifest in the nucleation, elongation, and curving of autophagosome membrane. We isolated a homolog of an ATG13 gene from the transcriptome database of the larva of the mealworm beetle, Tenebrio molitor (designated as TmATG13. The sequence analysis showed that TmATG13 cDNA comprises of 1,176 bp open reading frame that encodes a protein of 391 amino acids. Analyses of the structure-specific features of TmAtg13 showed an intrinsically disordered middle and C-terminal region, rich in regulatory phosphorylation sites. The N-terminal Atg13 domain show a HORMA (Hop1, Rev7, and Mad2 fold containing conserved amino acid residues across the Atg13 orthologs in insects. qRT-PCR revealed that TmATG13 was expressed ubiquitously in all the developmental stages of insect. TmATG13 mRNA expression was high in fat body and gut of the larval and adult stages of the insect. During ovary development and maturation, the TmATG13 transcripts showed high expression until six days of development, followed by a significant decline. The prospective functions mediated by TmAtg13 during autophagy will be clarified by further studies in the near future.

  6. Canonical transformations and the gauge dependence in general gauge theories

    International Nuclear Information System (INIS)

    Voronov, B.L.; Tyutin, I.V.

    1982-01-01

    Gauge-invariant renormalizability is proven for a general gauge theory with an arbitrary gauge condition. It is shown that a canonical change of the variables in the initial effective action generates just a canonical change of the variables in the renormalized action and in the vertex generating functional. It is noted that the gauge condition enters the effective action as a canonical transformation. As a consequence, a change of the gauge condition is equivalent to the canonical transformation of the renormalized action and the vertex generating functional and this fact, in turn, leads to the gauge invariance of the renormalized S matrix

  7. Higher spin gauge theories

    CERN Document Server

    Henneaux, Marc; Vasiliev, Mikhail A

    2017-01-01

    Symmetries play a fundamental role in physics. Non-Abelian gauge symmetries are the symmetries behind theories for massless spin-1 particles, while the reparametrization symmetry is behind Einstein's gravity theory for massless spin-2 particles. In supersymmetric theories these particles can be connected also to massless fermionic particles. Does Nature stop at spin-2 or can there also be massless higher spin theories. In the past strong indications have been given that such theories do not exist. However, in recent times ways to evade those constraints have been found and higher spin gauge theories have been constructed. With the advent of the AdS/CFT duality correspondence even stronger indications have been given that higher spin gauge theories play an important role in fundamental physics. All these issues were discussed at an international workshop in Singapore in November 2015 where the leading scientists in the field participated. This volume presents an up-to-date, detailed overview of the theories i...

  8. Continuum gauge theories

    International Nuclear Information System (INIS)

    Stora, R.

    1976-09-01

    The mathematics of gauge fields and some related concepts are discussed: some corrections on the principal fiber bundles emphasize the idea that the present formulation of continuum theories is incomplete. The main ingredients used through the construction of the renormalized perturbation series are then described: the Faddeev Popov argument, and the Faddeev Popov Lagrangian; the Slavnov symmetry and the nature of the Faddeev Popov ghost fields; the Slavnov identity, with an obstruction: the Adler Bardeen anomaly, and its generalization to the local cohomology of the gauge Lie algebra. Some smooth classical configurations of gauge fields which ought to play a prominent role in the evaluation of the functional integral describing the theory are also reviewed

  9. Deformed Gauge Theories

    Science.gov (United States)

    Wess, Julius

    Gauge theories are studied on a space of functions with the Moyal product. The development of these ideas follows the differential geometry of the usual gauge theories, but several changes are forced upon us. The Leibniz rule has to be changed such that the theory is now based on a twisted Hopf algebra. Nevertheless, this twisted symmetry structure leads to conservation laws. The symmetry has to be extended from Lie algebra valued to enveloping algebra valued and new vector potentials have to be introduced. As usual, field equations are subjected to consistency conditions that restrict the possible models. Some examples are studied.

  10. Accelerating abelian gauge dynamics

    CERN Document Server

    Adler, Stephen Louis

    1991-01-01

    In this paper, we suggest a new acceleration method for Abelian gauge theories based on linear transformations to variables which weight all length scales equally. We measure the autocorrelation time for the Polyakov loop and the plaquette at β=1.0 in the U(1) gauge theory in four dimensions, for the new method and for standard Metropolis updates. We find a dramatic improvement for the new method over the Metropolis method. Computing the critical exponent z for the new method remains an important open issue.

  11. Effective gauge theory

    International Nuclear Information System (INIS)

    Ebata, Takeshi

    1982-01-01

    The global iso-spin invariance of the hadronic interaction, which is a reflection of the SU(2) x U(1) QFD and QCD, as well as the U(1) invariance related to the charge of the hadrons, is formulated as an effective gauge theory. The pseudo-gauge fields in this theory are the vector mesons, and these composite fields become massive when the Higgs field at the quark-lepton level and the anti qq pair states acquire the vacuum expectation value. The formulation gives a theoretical basis for the vector dominance model and gives some insights to the possible composite structure of quarks and leptons. (author)

  12. Instantons in gauge theories

    CERN Document Server

    1994-01-01

    This volume is a compilation of works which, taken together, give a complete and consistent presentation of instanton calculus in non-Abelian gauge theories, as it exists now. Some of the papers reproduced are instanton classics. Among other things, they show from a historical perspective how the instanton solution has been found, the motivation behind it and how the physical meaning of instantons has been revealed. Other papers are devoted to different aspects of instanton formalism including instantons in supersymmetric gauge theories. A few unsolved problems associated with instantons are d

  13. Holographic Gauge Mediation

    Energy Technology Data Exchange (ETDEWEB)

    Benini, Francesco; /Princeton U.; Dymarsky, Anatoly; /Stanford U., ITP; Franco, Sebastian; /Santa Barbara, KITP; Kachru, Shamit; Simic, Dusan; /Stanford U., ITP /SLAC; Verlinde, Herman; /Princeton, Inst. Advanced Study

    2009-06-19

    We discuss gravitational backgrounds where supersymmetry is broken at the end of a warped throat, and the SUSY-breaking is transmitted to the Standard Model via gauginos which live in (part of) the bulk of the throat geometry. We find that the leading effect arises from splittings of certain 'messenger mesons,' which are adjoint KK-modes of the D-branes supporting the Standard Model gauge group. This picture is a gravity dual of a strongly coupled field theory where SUSY is broken in a hidden sector and transmitted to the Standard Model via a relative of semi-direct gauge mediation.

  14. ATG16L1: A multifunctional susceptibility factor in Crohn disease.

    Science.gov (United States)

    Salem, Mohammad; Ammitzboell, Mette; Nys, Kris; Seidelin, Jakob Benedict; Nielsen, Ole Haagen

    2015-04-03

    Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1 (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have been associated with an increased risk of developing Crohn disease. The most common and well-studied genetic variant of ATG16L1 (rs2241880; leading to a T300A conversion) exhibits a strong association with risk for developing Crohn disease. The rs2241880 variant plays a crucial role in pathogen clearance, resulting in imbalanced cytokine production, and is linked to other biological processes, such as the endoplasmic reticulum stress/unfolded protein response. In this review, we focus on the importance of ATG16L1 and its genetic variant (T300A) within the elementary biological processes linked to Crohn disease.

  15. Some observations on interpolating gauges and non-covariant gauges

    Indian Academy of Sciences (India)

    covariant gauges starting from the covariant ones. We draw attention to the need for a very careful treatment of boundary condition defining term. We show that the boundary condition needed to maintain gauge- invariance as the interpolating ...

  16. Freudenthal Gauge Theory

    CERN Document Server

    Marrani, Alessio; Shih, Sheng-Yu Darren; Tagliaferro, Anthony; Zumino, Bruno

    2013-01-01

    We present a novel gauge field theory, based on the Freudenthal Triple System (FTS), a ternary algebra with mixed symmetry (not completely symmetric) structure constants. The theory, named Freudenthal Gauge Theory (FGT), is invariant under two (off-shell) symmetries: the gauge Lie algebra constructed from the FTS triple product and a novel global non-polynomial symmetry, the so-called Freudenthal duality. Interestingly, a broad class of FGT gauge algebras is provided by the Lie algebras "of type e7" which occur as conformal symmetries of Euclidean Jordan algebras of rank 3, and as U-duality algebras of the corresponding (super)gravity theories in D = 4. We prove a No-Go Theorem, stating the incompatibility of the invariance under Freudenthal duality and the coupling to space-time vector and/or spinor fields, thus forbidding non-trivial supersymmetric extensions of FGT. We also briefly discuss the relation between FTS and the triple systems occurring in BLG-type theories, in particular focusing on superconform...

  17. lattice gauge theory

    Indian Academy of Sciences (India)

    activities in non-perturbative QCD. Keywords. Deflation; overlap operator; GPU; CUDA. PACS Nos 11.15.Ha; 12.38.-t. 1. Introduction. The lattice gauge theory subgroup of the working group in non-perturbative QCD consisted of Mridupavan Deka, Sourendu Gupta, N D Hari Dass, Rajarshi Roy, Sayantan Sharma and.

  18. Industrial nuclear gauges

    International Nuclear Information System (INIS)

    Bennerstedt, T.

    1986-01-01

    A great number of industrial nuclear gauges are used in Sweden. The administrative routines for testing, approval and licensing are briefly described. Safety standards, including basic ICRP criteria, are summarized and a theoretical background to the various measuring techniques is given. Numerous practical examples are given. (author)

  19. Dielectric lattice gauge theory

    International Nuclear Information System (INIS)

    Mack, G.

    1983-06-01

    Dielectric lattice gauge theory models are introduced. They involve variables PHI(b)epsilong that are attached to the links b = (x+esub(μ),x) of the lattice and take their values in the linear space g which consists of real linear combinations of matrices in the gauge group G. The polar decomposition PHI(b)=U(b)osub(μ)(x) specifies an ordinary lattice gauge field U(b) and a kind of dielectric field epsilonsub(ij)proportionalosub(i)osub(j)sup(*)deltasub(ij). A gauge invariant positive semidefinite kinetic term for the PHI-field is found, and it is shown how to incorporate Wilson fermions in a way which preserves Osterwalder Schrader positivity. Theories with G = SU(2) and without matter fields are studied in some detail. It is proved that confinement holds, in the sense that Wilson loop expectation values show an area law decay, if the Euclidean action has certain qualitative features which imply that PHI = 0 (i.e. dielectric field identical 0) is the unique maximum of the action. (orig.)

  20. Solution of the gauge identities in the axial gauge

    International Nuclear Information System (INIS)

    Delbourgo, R.

    1981-01-01

    Starting from the spectral representation of the two-point functions in the axial gauge, the gauge identities are solved so as to express the higher-point Green functions linearly in terms of the two-point spectral function. The four-point functions are an important input for investigations of scalar electrodynamics and vector chromodynamics based on the gauge technique. (author)

  1. Gauge symmetry breaking in gauge theories -- in search of clarification

    NARCIS (Netherlands)

    Friederich, Simon

    2013-01-01

    The paper investigates the spontaneous breaking of gauge symmetries in gauge theories from a philosophical angle, taking into account the fact that the notion of a spontaneously broken local gauge symmetry, though widely employed in textbook expositions of the Higgs mechanism, is not supported by

  2. Some observations on interpolating gauges and non-covariant gauges

    Indian Academy of Sciences (India)

    We discuss the viability of using interpolating gauges to define the non-covariant gauges starting from the covariant ones. We draw attention to the need for a very careful treatment of boundary condition defining term. We show that the boundary condition needed to maintain gauge-invariance as the interpolating parameter ...

  3. Molecular cloning and characterization of autophagy-related gene TmATG8 in Listeria-invaded hemocytes of Tenebrio molitor.

    Science.gov (United States)

    Tindwa, Hamisi; Jo, Yong Hun; Patnaik, Bharat Bhusan; Lee, Yong Seok; Kang, Sang Sun; Han, Yeon Soo

    2015-07-01

    Macroautophagy (hereinafter called autophagy) is a highly regulated process used by eukaryotic cells to digest portions of the cytoplasm that remodels and recycles nutrients and disposes of unwanted cytoplasmic constituents. Currently 36 autophagy-related genes (ATG) and their homologs have been characterized in yeast and higher eukaryotes, including insects. In the present study, we identified and functionally characterized the immune function of an ATG8 homolog in a coleopteran insect, Tenebrio molitor (TmATG8). The cDNA of TmATG8 comprises of an ORF of 363 bp that encodes a protein of 120 amino acid residues. TmATG8 transcripts are detected in all the developmental stages analyzed. TmAtg8 protein contains a highly conserved C-terminal glycine residue (Gly116) and shows high amino acid sequence identity (98%) to its Tribolium castaneum homolog, TcAtg8. Loss of function of TmATG8 by RNAi led to a significant increase in the mortality rates of T. molitor larvae against Listeria monocytogenes. Unlike dsEGFP-treated control larvae, TmATG8-silenced larvae failed to turn-on autophagy in hemocytes after injection with L. monocytogenes. These data suggest that TmATG8 play a role in mediating autophagy-based clearance of Listeria in T. molitor. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Weighing Rain Gauge Recording Charts

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Weighing rain gauge charts record the amount of precipitation that falls at a given location. The vast majority of the Weighing Rain Gauge Recording Charts...

  5. Hypotony after 25-gauge vitrectomy

    NARCIS (Netherlands)

    Bamonte, Giulio; Mura, Marco; Stevie Tan, H.

    2011-01-01

    To describe the incidence of hypotony after 25-gauge vitrectomy and to identify preoperative and intraoperative factors that influence the occurrence of hypotony. Retrospective, nonrandomized, interventional case series. We reviewed 122 consecutive cases of 25-gauge vitrectomy for all surgical

  6. More on generalized gauge hierarchies

    International Nuclear Information System (INIS)

    Ozer, M.

    1982-05-01

    We point out that the generalized gauge hierarchy evolution equation of Dawson and Georgi for the gauge coupling constants of the subgroups of a unifying group should be modified in order to make it applicable to all the unifying groups. We modify their formula, and in the process derive a formula relating the gauge couplings of the subgroups and the gauge coupling of the unifying group at the unification mass scale. (author)

  7. Lattices for laymen: a non-specialist's introduction to lattice gauge theory

    International Nuclear Information System (INIS)

    Callaway, D.J.E.

    1985-01-01

    The review on lattice gauge theory is based upon a series of lectures given to the Materials Science and Technology Division at Argonne National Laboratory. Firstly the structure of gauge theories in the continuum is discussed. Then the lattice formulation of these theories is presented, including quantum electrodynamics and non-abelian lattice gauge theories. (U.K.)

  8. Renormalisation group flows for gauge theories in axial gauges

    CERN Document Server

    Litim, Daniel F; Litim, Daniel F.; Pawlowski, Jan M.

    2002-01-01

    Gauge theories in axial gauges are studied using Exact Renormalisation Group flows. We introduce a background field in the infrared regulator, but not in the gauge fixing, in contrast to the usual background field gauge. It is shown how heat-kernel methods can be used to obtain approximate solutions to the flow and the corresponding Ward identities. Expansion schemes are discussed, which are not applicable in covariant gauges. As an application, we derive the one-loop effective action for covariantly constant field strength, and the one-loop beta-function for arbitrary regulator.

  9. Gauge fixing and operator ordering

    International Nuclear Information System (INIS)

    Tudron, T.N.

    1980-01-01

    In a large class of gauges, including the Coulomb gauge, in non-Abelian gauge theories, an operator-ordering ambiguity exists in the canonically quantized Hamiltonian. In this paper, a method is described for resolving this ambiguity. It gives rise to an extra potential-like term of order h 2

  10. Safety of hydrogen pressure gauges.

    Science.gov (United States)

    Voth, R. O.

    1972-01-01

    Study of the relative safety afforded an operator by various hydrogen-pressure gauge case designs. It is shown that assurance of personnel safety, should a failure occur, requires careful selection of available gauge designs, together with proper mounting. Specific gauge case features and mounting requirements are recommended.

  11. The renaissance of gauge theory

    International Nuclear Information System (INIS)

    Moriyasu, K.

    1982-01-01

    Gauge theory is a classic example of a good idea proposed before its time. A brief historical review of gauge theory is presented to see why it required over 50 years for gauge invariance to be rediscovered as the basic principle governing the fundamental forces of Nature. (author)

  12. Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34(+) Hematopoietic Stem-Progenitor Cells.

    Science.gov (United States)

    Gomez-Puerto, Maria Catalina; Folkerts, Hendrik; Wierenga, Albertus T J; Schepers, Koen; Schuringa, Jan Jacob; Coffer, Paul J; Vellenga, Edo

    2016-06-01

    Autophagy is a highly regulated catabolic process that involves sequestration and lysosomal degradation of cytosolic components such as damaged organelles and misfolded proteins. While autophagy can be considered to be a general cellular housekeeping process, it has become clear that it may also play cell type-dependent functional roles. In this study, we analyzed the functional importance of autophagy in human hematopoietic stem/progenitor cells (HSPCs), and how this is regulated during differentiation. Western blot-based analysis of LC3-II and p62 levels, as well as flow cytometry-based autophagic vesicle quantification, demonstrated that umbilical cord blood-derived CD34(+) /CD38(-) immature hematopoietic progenitors show a higher autophagic flux than CD34(+) /CD38(+) progenitors and more differentiated myeloid and erythroid cells. This high autophagic flux was critical for maintaining stem and progenitor function since knockdown of autophagy genes ATG5 or ATG7 resulted in reduced HSPC frequencies in vitro as well as in vivo. The reduction in HSPCs was not due to impaired differentiation, but at least in part due to reduced cell cycle progression and increased apoptosis. This is accompanied by increased expression of p53, proapoptotic genes BAX and PUMA, and the cell cycle inhibitor p21, as well as increased levels of cleaved caspase-3 and reactive oxygen species. Taken together, our data demonstrate that autophagy is an important regulatory mechanism for human HSCs and their progeny, reducing cellular stress and promoting survival. Stem Cells 2016;34:1651-1663. © 2016 AlphaMed Press.

  13. The string unification of gauge couplings and gauge kinetic mixings

    International Nuclear Information System (INIS)

    Hattori, Chuichiro; Matsuda, Masahisa; Matsuoka, Takeo; Mochinaga, Daizo.

    1993-01-01

    In the superstring models we have not only the complete 27 multiplets of E 6 but also extra incomplete (27+27-bar) chiral supermultiplets being alive at low energies. Associated with these additional multiplets, when the gauge symmetry contains more than one U(1) gauge group, there may exist gauge kinetic mixings among these U(1) gauge groups. In such cases the effect of gauge kinetic mixings should be incorporated into the study of unification of gauge couplings. We study these interesting effects systematically in these models. The string threshold effect is also taken into account. It is found that in the four-generation models we do not have an advisable solution of string unification of gauge couplings consistent with experimental values at the electroweak scale. We also discuss the possible scenarios to solve this problem. (author)

  14. Quantization of 2D Abelian Gauge Theory without the Kinetic Term of Gauge Field as Anomalous Gauge Theory

    OpenAIRE

    Koseki, M.; Kuriki, R.

    1995-01-01

    The massless Schwinger model without the kinetic term of gauge field has gauge anomaly. We quantize the model as an anomalous gauge theory in the most general class of gauge conditions. We show that the gauge field becomes a dynamical variable because of gauge anomaly.

  15. Dark discrete gauge symmetries

    International Nuclear Information System (INIS)

    Batell, Brian

    2011-01-01

    We investigate scenarios in which dark matter is stabilized by an Abelian Z N discrete gauge symmetry. Models are surveyed according to symmetries and matter content. Multicomponent dark matter arises when N is not prime and Z N contains one or more subgroups. The dark sector interacts with the visible sector through the renormalizable kinetic mixing and Higgs portal operators, and we highlight the basic phenomenology in these scenarios. In particular, multiple species of dark matter can lead to an unconventional nuclear recoil spectrum in direct detection experiments, while the presence of new light states in the dark sector can dramatically affect the decays of the Higgs at the Tevatron and LHC, thus providing a window into the gauge origin of the stability of dark matter.

  16. Radioactive thickness gauge (1962)

    International Nuclear Information System (INIS)

    Guizerix, J.

    1962-01-01

    The author describes a thickness gauge in which the scintillating crystal detector alternately 'sees' a radioactive source through the material which is to be measured and then a control source of the same material; the radiations are separated in time by an absorbing valve whose sections are alternately full and hollow. The currents corresponding to the two sources are separated beyond the photomultiplier tube by a detector synchronized with the rotation of the valve. The quotient of these two currents is then obtained with a standard recording potentiometer. It is found that the average value of the response which is in the form G = f(I 1 /I 2 ) is not affected by decay of the radioactive sources, and that it is little influenced by variations of high tension, temperature, or properties of the air in the source detector interval. The performance of the gauge is given. (author) [fr

  17. The quantum gauge principle

    CERN Document Server

    Graudenz, Dirk

    1996-01-01

    We consider the evolution of quantum fields on a classical background space-time, formulated in the language of differential geometry. Time evolution along the worldlines of observers is described by parallel transport operators in an infinite-dimensional vector bundle over the space-time manifold. The time evolution equation and the dynamical equations for the matter fields are invariant under an arbitrary local change of frames along the restriction of the bundle to the worldline of an observer, thus implementing a ``quantum gauge principle''. We derive dynamical equations for the connection and a complex scalar quantum field based on a gauge field action. In the limit of vanishing curvature of the vector bundle, we recover the standard equation of motion of a scalar field in a curved background space-time.

  18. Semistrict higher gauge theory

    Energy Technology Data Exchange (ETDEWEB)

    Jurčo, Branislav [Mathematical Institute, Faculty of Mathematics and Physics, Charles University in Prague,Prague 186 75 (Czech Republic); Sämann, Christian [Maxwell Institute for Mathematical Sciences, Department of Mathematics,Heriot-Watt University,Edinburgh EH14 4AS (United Kingdom); Wolf, Martin [Department of Mathematics, University of Surrey,Guildford GU2 7XH (United Kingdom)

    2015-04-20

    We develop semistrict higher gauge theory from first principles. In particular, we describe the differential Deligne cohomology underlying semistrict principal 2-bundles with connective structures. Principal 2-bundles are obtained in terms of weak 2-functors from the Čech groupoid to weak Lie 2-groups. As is demonstrated, some of these Lie 2-groups can be differentiated to semistrict Lie 2-algebras by a method due to Ševera. We further derive the full description of connective structures on semistrict principal 2-bundles including the non-linear gauge transformations. As an application, we use a twistor construction to derive superconformal constraint equations in six dimensions for a non-Abelian N=(2,0) tensor multiplet taking values in a semistrict Lie 2-algebra.

  19. Quantized gauge field

    International Nuclear Information System (INIS)

    Arodz, H.

    1987-01-01

    The two formulations of quantum theory of the free electromagnetic field are presented. In the Coulomb gauge approach the independent dynamical variables have been identified and then, in order to quantize the theory, it has been sufficient to apply the straightforward canonical quantization. In the Gupta-Bleuler approach the auxilliary theory is first considered. The straightforward canonical quantization of it leads to the quantum theory defined in the space G with indefinite norm. 15 refs. (author)

  20. Triple gauge boson couplings

    CERN Document Server

    Gounaris, George J; Zeppenfeld, Dieter; Ajaltouni, Ziad J; Arhrib, A; Bella, G; Berends, F A; Bilenky, S M; Blondel, A; Busenitz, J K; Choudhury, D; Clarke, P; Conboy, J E; Diehl, M; Fassouliotis, D; Frère, J M; Georgiopoulos, C H; Gibbs, M; Grünewald, M W; Hansen, J B; Hartmann, C; Jin, B N; Jousset, J; Kalinowski, Jan; Kocian, M L; Lahanas, Athanasios B; Layssac, J; Lieb, E H; Markou, C; Matteuzzi, C; Mättig, P; Moreno, J M; Moultaka, G; Nippe, A; Orloff, J; Papadopoulos, C G; Paschalis, J; Petridou, C; Phillips, H; Podlyski, F; Pohl, M; Renard, F M; Rossignol, J M; Rylko, R; Sekulin, R L; Van Sighem, A; Simopoulou, Errietta; Skillman, A; Spanos, V C; Tonazzo, A; Tytgat, M H G; Tzamarias, S; Verzegnassi, Claudio; Vlachos, N D; Zevgolatakos, E

    1996-01-01

    We present the results obtained by the "Triple Gauge Couplings" working group during the LEP2 Workshop (1994-1995). The report concentrates on the measurement of WW\\gamma and WWZ couplings in e^-e^+\\to W^-W^+ or, more generally, four-fermion production at LEP2. In addition the detection of new interactions in the bosonic sector via other production channels is discussed.

  1. Gauging the octonion algebra

    International Nuclear Information System (INIS)

    Waldron, A.K.; Joshi, G.C.

    1992-01-01

    By considering representation theory for non-associative algebras the fundamental adjoint representations of the octonion algebra is constructed. It is then shown how these representations by associative matrices allow a consistent octonionic gauge theory to be realized. It was found that non-associativity implies the existence of new terms in the transformation laws of fields and the kinetic term of an octonionic Lagrangian. 13 refs

  2. Gauge color codes

    DEFF Research Database (Denmark)

    Bombin Palomo, Hector

    2015-01-01

    Color codes are topological stabilizer codes with unusual transversality properties. Here I show that their group of transversal gates is optimal and only depends on the spatial dimension, not the local geometry. I also introduce a generalized, subsystem version of color codes. In 3D they allow t...... the transversal implementation of a universal set of gates by gauge fixing, while error-dectecting measurements involve only four or six qubits....

  3. The autophagy-related gene BcATG1 is involved in fungal development and pathogenesis in Botrytis cinerea.

    Science.gov (United States)

    Ren, Weichao; Zhang, Zhihui; Shao, Wenyong; Yang, Yalan; Zhou, Mingguo; Chen, Changjun

    2017-02-01

    Autophagy, a ubiquitous intracellular degradation process, is conserved from yeasts to humans. It serves as a major survival function during nutrient depletion stress and is crucial for correct growth and differentiation. In this study, we characterized an atg1 orthologue Bcatg1 in the necrotrophic plant pathogen Botrytis cinerea. Quantitative real-time polymerase chain reaction (qRT-PCR) assays showed that the expression of BcATG1 was up-regulated under carbon or nitrogen starvation conditions. BcATG1 could functionally restore the survival defects of the yeast ATG1 mutant during nitrogen starvation. Deletion of BcATG1 (ΔBcatg1) inhibited autophagosome accumulation in the vacuoles of nitrogen-starved cells. ΔBcatg1 was dramatically impaired in vegetative growth, conidiation and sclerotial formation. In addition, most conidia of ΔBcatg1 lost the capacity to form the appressorium infection structure and failed to penetrate onion epidermis. Pathogenicity assays showed that the virulence of ΔBcatg1 on different host plant tissues was drastically impaired, which was consistent with its inability to form an appressorium. Moreover, lipid droplet accumulation was significantly reduced in the conidia of ΔBcatg1, but the glycerol content was increased. All of the defects of ΔBcatg1 were complemented by re-introduction of an intact copy of the wild-type BcATG1 into the mutant. These results indicate that BcATG1 plays a critical role in numerous developmental processes and is essential to the pathogenesis of B. cinerea. © 2016 BSPP AND JOHN WILEY & SONS LTD.

  4. Gauging Variational Inference

    Energy Technology Data Exchange (ETDEWEB)

    Chertkov, Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ahn, Sungsoo [Korea Advanced Inst. Science and Technology (KAIST), Daejeon (Korea, Republic of); Shin, Jinwoo [Korea Advanced Inst. Science and Technology (KAIST), Daejeon (Korea, Republic of)

    2017-05-25

    Computing partition function is the most important statistical inference task arising in applications of Graphical Models (GM). Since it is computationally intractable, approximate methods have been used to resolve the issue in practice, where meanfield (MF) and belief propagation (BP) are arguably the most popular and successful approaches of a variational type. In this paper, we propose two new variational schemes, coined Gauged-MF (G-MF) and Gauged-BP (G-BP), improving MF and BP, respectively. Both provide lower bounds for the partition function by utilizing the so-called gauge transformation which modifies factors of GM while keeping the partition function invariant. Moreover, we prove that both G-MF and G-BP are exact for GMs with a single loop of a special structure, even though the bare MF and BP perform badly in this case. Our extensive experiments, on complete GMs of relatively small size and on large GM (up-to 300 variables) confirm that the newly proposed algorithms outperform and generalize MF and BP.

  5. Lopsided Gauge Mediation

    CERN Document Server

    De Simone, Andrea; Giudice, Gian Francesco; Pappadopulo, Duccio; Rattazzi, Riccardo

    2011-01-01

    It has been recently pointed out that the unavoidable tuning among supersymmetric parameters required to raise the Higgs boson mass beyond its experimental limit opens up new avenues for dealing with the so called $\\mu$-$B_\\mu$ problem of gauge mediation. In fact, it allows for accommodating, with no further parameter tuning, large values of $B_\\mu$ and of the other Higgs-sector soft masses, as predicted in models where both $\\mu$ and $B_\\mu$ are generated at one-loop order. This class of models, called Lopsided Gauge Mediation, offers an interesting alternative to conventional gauge mediation and is characterized by a strikingly different phenomenology, with light higgsinos, very large Higgs pseudoscalar mass, and moderately light sleptons. We discuss general parametric relations involving the fine-tuning of the model and various observables such as the chargino mass and the value of $\\tan\\beta$. We build an explicit model and we study the constraints coming from LEP and Tevatron. We show that in spite of ne...

  6. Gauge field theory

    International Nuclear Information System (INIS)

    Aref'eva, I.Ya.; Slavnov, A.A.

    1981-01-01

    This lecture is devoted to the discussion of gauge field theory permitting from the single point of view to describe all the interactions of elementary particles. The authors used electrodynamics and the Einstein theory of gravity to search for a renormgroup fixing a form of Lagrangian. It is shown that the gauge invariance added with the requirement of the minimum number of arbitraries in Lagrangian fixes unambigously the form of the electromagnetic interaction. The generalization of this construction for more complicate charge spaces results in the Yang-Mills theory. The interaction form in this theory is fixed with the relativity principle in the charge space. A quantum scheme of the Yang-Mills fields through the explicit separation of true dynamic variables is suggested. A comfortable relativistically invariant diagram technique for the calculation of a producing potential for the Green functions is described. The Ward generalized identities have been obtained and a procedure of the elimination of ultraviolet and infrared divergencies has been accomplished. Within the framework of QCD (quantum-chromodynamic) the phenomenon of the asymptotic freedom being the most successful prediction of the gauge theory of strong interactions was described. Working methods with QCD outside the framework of the perturbation theory have been described from a coupling constant. QCD is represented as a single theory possessing both the asymptotical freedom and the freedom retaining quarks [ru

  7. Association of ATG16L1 gene haplotype with inflammatory bowel disease in Indians.

    Directory of Open Access Journals (Sweden)

    Srinivasan Pugazhendhi

    Full Text Available Inflammatory bowel disease (IBD is characterized by multigenic inheritance. Defects in autophagy related genes are considered to show genetic heterogeneity between populations. We evaluated the association of several single nucleotide polymorphisms (SNPs in the autophagy related 16 like 1 (ATG16L1 gene with IBD in Indians. The ATG16L1 gene was genotyped for ten different SNPs using DNA extracted from peripheral blood of 234 patients with Crohn's disease (CD, 249 patients with ulcerative colitis (UC and 393 healthy controls The SNPs rs2241880, rs4663396, rs3792106, rs10210302, rs3792109, rs2241877, rs6737398, rs11682898, rs4663402 and rs4663421 were genotyped using the Sequenom MassArray platform. PLINK was used for the association analysis and pairwise linkage disequilibrium (LD values. Haplotype analysis was done using Haploview. All SNPs were in Hardy Weinberg equilibrium in cases and controls. The G allele at rs6737398 exhibited a protective association with both CD and UC. The T allele at rs4663402 and C allele at rs4663421 were positively associated with CD and UC. The T allele at rs2241877 exhibited protective association with UC only. The AA genotype at rs4663402 and the GG genotype at rs4663421 were protectively associated with both CD and UC. Haplotype analysis revealed that all the SNPs in tight LD (D' = 0.76-1.0 and organized in a single haplotype block. Haplotype D was positively associated with IBD (P = 5.8 x 10-6 for CD and 0.002 for UC. SNPs in ATG16L1 were associated with IBD in Indian patients. The relevance to management of individual patients requires further study.

  8. Autophagy-Associated Protein SmATG12 Is Required for Fruiting-Body Formation in the Filamentous Ascomycete Sordaria macrospora.

    Directory of Open Access Journals (Sweden)

    Antonia Werner

    Full Text Available In filamentous fungi, autophagy functions as a catabolic mechanism to overcome starvation and to control diverse developmental processes under normal nutritional conditions. Autophagy involves the formation of double-membrane vesicles, termed autophagosomes that engulf cellular components and bring about their degradation via fusion with vacuoles. Two ubiquitin-like (UBL conjugation systems are essential for the expansion of the autophagosomal membrane: the UBL protein ATG8 is conjugated to the lipid phosphatidylethanolamine and the UBL protein ATG12 is coupled to ATG5. We recently showed that in the homothallic ascomycete Sordaria macrospora autophagy-related genes encoding components of the conjugation systems are required for fruiting-body development and/or are essential for viability. In the present work, we cloned and characterized the S. macrospora (Smatg12 gene. Two-hybrid analysis revealed that SmATG12 can interact with SmATG7 and SmATG3. To examine its role in S. macrospora, we replaced the open reading frame of Smatg12 with a hygromycin resistance cassette and generated a homokaryotic ΔSmatg12 knockout strain, which displayed slower vegetative growth under nutrient starvation conditions and was unable to form fruiting bodies. In the hyphae of S. macrospora EGFP-labeled SmATG12 was detected in the cytoplasm and as punctate structures presumed to be phagophores or phagophore assembly sites. Delivery of EGFP-labelled SmATG8 to the vacuole was entirely dependent on SmATG12.

  9. Fourier acceleration in lattice gauge theories. I. Landau gauge fixing

    International Nuclear Information System (INIS)

    Davies, C.T.H.; Batrouni, G.G.; Katz, G.R.; Kronfeld, A.S.; Lepage, G.P.; Wilson, K.G.; Rossi, P.; Svetitsky, B.

    1988-01-01

    Fourier acceleration is a useful technique which can be applied to many different numerical algorithms in order to alleviate the problem of critical slowing down. Here we describe its application to an optimization problem in the simulation of lattice gauge theories, that of gauge fixing a configuration of link fields to the Landau gauge (partial/sub μ/A/sup μ/ = 0). We find that a steepest-descents method of gauge fixing link fields at β = 5.8 on an 8 4 lattice can be made 5 times faster using Fourier acceleration. This factor will grow as the volume of the lattice is increased. We also discuss other gauges that are useful to lattice-gauge-theory simulations, among them one that is a combination of the axial and Landau gauges. This seems to be the optimal gauge to impose for the Fourier acceleration of two other important algorithms, the inversion of the fermion matrix and the updating of gauge field configurations

  10. Conformal anomaly from gauge fields without gauge fixing

    Science.gov (United States)

    Falls, Kevin; Morris, Tim R.

    2018-03-01

    We show how the Weyl anomaly generated by gauge fields, can be computed from manifestly gauge invariant and diffeomorphism invariant exact renormalization group equations, without having to fix the gauge at any stage. Regularization is provided by covariant higher derivatives and by embedding the Maxwell field into a spontaneously broken U (1 |1 ) supergauge theory. We first provide a realization that leaves behind two versions of the original U (1 ) gauge field, and then construct a manifestly U (1 |1 ) supergauge invariant flow equation which leaves behind only the original Maxwell field in the spontaneously broken regime.

  11. Wireless digital pressure gauge based on nanomaterials

    Science.gov (United States)

    Abay, Dilyara; Otarbay, Zhuldyz; Token, Madengul; Guseinov, Nazim; Muratov, Mukhit; Gabdullin, Maratbek; Ismailov, Daniyar

    2018-03-01

    In the article studies the efficiency of using nanostructured nickel copper films as thin films for bending sensors. Thin films of nickel-copper alloy were deposited using magnetron sputtering technology followed by the appropriate masks. Scanning electron microscopy (SEM) and energy- dispersive X-ray spectroscopy (EDS) techniques were used to examine structure and surface of the Ni Cu coatings. The results of the bending sensors result indicated that the Ni Cu thin film strain gauge showed an excellent sensitive.

  12. Gauge concepts in theoretical applied physics

    Science.gov (United States)

    Tan, Seng Ghee; Jalil, Mansoor B. A.

    2016-01-01

    Gauge concept evolves in the course of nearly one century from Faraday’s rather obscure electrotonic state of matter to the physically significant Yang-Mills that underpin today’s standard model. As gauge theories improve, links are established with modern observations, e.g. in the Aharonov-Bohm effect, the Pancharatnam-Berry’s phase, superconductivity, and quantum Hall effects. In this century, emergent gauge theory is formulated in numerous fields of applied physics like topological insulators, spintronics, and graphene. We will show in this paper the application of gauge theory in two particularly useful spin-based phenomena, namely the spin orbit spin torque and the spin Hall effect. These are important fields of study in the engineering community due to great commercial interest in the technology of magnetic memory (MRAM), and magnetic field sensors. Both spin orbit torque and spin Hall perform magnetic switching at low power and high speed. Furthermore, spin Hall is also a promising source of pure spin current, as well as a reliable form of detection mechanism for the magnetic state of a material.

  13. Crohn disease ATG16L1 polymorphism increases susceptibility to infection with Helicobacter pylori in humans.

    Science.gov (United States)

    Raju, Deepa; Hussey, Séamus; Jones, Nicola L

    2012-09-01

    Autophagy plays key roles both in host defense against bacterial infection and in tumor biology. Helicobacter pylori (H. pylori) infection causes chronic gastritis and is the single most important risk factor for the development of gastric cancer in humans. Its vacuolating cytotoxin (VacA) promotes gastric colonization and is associated with more severe disease. Acute exposure to VacA initially triggers host autophagy to mitigate the effects of the toxin in epithelial cells. Recently, we demonstrated that chronic exposure to VacA leads to the formation of defective autophagosomes that lack CTSD/cathepsin D and have reduced catalytic activity. Disrupted autophagy results in accumulation of reactive oxygen species and SQSTM1/p62 both in vitro and in vivo in biopsy samples from patients infected with VacA(+) but not VacA(-) strains. We also determined that the Crohn disease susceptibility polymorphism in the essential autophagy gene ATG16L1 increases susceptibility to H. pylori infection. Furthermore, peripheral blood monocytes from individuals with the ATG16L1 risk variant show impaired autophagic responses to VacA exposure. This is the first study to identify both a host autophagy susceptibility gene for H. pylori infection and to define the mechanism by which the autophagy pathway is affected following H. pylori infection. Collectively, these findings highlight the synergistic effects of host and bacterial autophagy factors on H. pylori pathogenesis and the potential for subsequent cancer susceptibility.

  14. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5.

    Science.gov (United States)

    Nezich, Catherine L; Wang, Chunxin; Fogel, Adam I; Youle, Richard J

    2015-08-03

    The kinase PINK1 and ubiquitin ligase Parkin can regulate the selective elimination of damaged mitochondria through autophagy (mitophagy). Because of the demand on lysosomal function by mitophagy, we investigated a role for the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in this process. We show that during mitophagy TFEB translocates to the nucleus and displays transcriptional activity in a PINK1- and Parkin-dependent manner. MITF and TFE3, homologues of TFEB belonging to the same microphthalmia/transcription factor E (MiT/TFE) family, are similarly regulated during mitophagy. Unlike TFEB translocation after starvation-induced mammalian target of rapamycin complex 1 inhibition, Parkin-mediated TFEB relocalization required Atg9A and Atg5 activity. However, constitutively active Rag guanosine triphosphatases prevented TFEB translocation during mitophagy, suggesting cross talk between these two MiT/TFE activation pathways. Analysis of clustered regularly interspaced short palindromic repeats-generated TFEB/MITF/TFE3/TFEC single, double, and triple knockout cell lines revealed that these proteins partly facilitate Parkin-mediated mitochondrial clearance. These results illuminate a pathway leading to MiT/TFE transcription factor activation, distinct from starvation-induced autophagy, which occurs during mitophagy.

  15. Using microbes as a key tool to unravel the mechanism of autophagy and the functions of the ATG proteins

    Directory of Open Access Journals (Sweden)

    Mario Mauthe

    2016-12-01

    Full Text Available The study of microbe infections has always been a very effective approach to unveil and dissect cellular pathways. Autophagy is not an exception. Although some of the breakthrough discoveries in the field were obtained using yeast, pathogens have been and still are a great tool to discover and characterize new molecular and functional aspects of autophagy. Research on pathogens has helped to acquire knowledge about selective types of autophagy and the assembly of the autophagy machinery, i.e the autophagy-related (ATG proteins, but also about alternative cellular roles of this pathway, such as secretion. Finally, microbes have also served to discover and characterize unconventional functions of the ATG proteins, which are uncoupled from their role in autophagy. In our recent study, we have taken advantage of viruses as a screening tool to determine the extent of the unconventional functions of the ATG proteome and characterize one of them.

  16. Comments on general gauge mediation

    International Nuclear Information System (INIS)

    Intriligator, Kenneth; Sudano, Matthew

    2008-01-01

    There has been interest in generalizing models of gauge mediation of supersymmetry breaking. As shown by Meade, Seiberg, and Shih (MSS), the soft masses of general gauge mediation can be expressed in terms of the current two-point functions of the susy-breaking sector. We here give a simple extension of their result which provides, for general gauge mediation, the full effective potential for squark pseudo-D-flat directions. The effective potential reduces to the sfermion soft masses near the origin, and the full potential, away from the origin, can be useful for cosmological applications. We also generalize the soft masses and effective potential to allow for general gauge mediation by Higgsed gauge groups. Finally, we discuss general gauge mediation in the limit of small F-terms, and how the results of MSS connect with the analytic continuation in superspace results, based on a spurion analysis.

  17. The Xenopus laevis Atg4B Protease: Insights into Substrate Recognition and Application for Tag Removal from Proteins Expressed in Pro- and Eukaryotic Hosts.

    Directory of Open Access Journals (Sweden)

    Steffen Frey

    Full Text Available During autophagy, members of the ubiquitin-like Atg8 protein family get conjugated to phosphatidylethanolamine and act as protein-recruiting scaffolds on the autophagosomal membrane. The Atg4 protease produces mature Atg8 from C-terminally extended precursors and deconjugates lipid-bound Atg8. We now found that Xenopus laevis Atg4B (xAtg4B is ideally suited for proteolytic removal of N-terminal tags from recombinant proteins. To implement this strategy, an Atg8 cleavage module is inserted in between tag and target protein. An optimized xAtg4B protease fragment includes the so far uncharacterized C-terminus, which crucially contributes to recognition of the Xenopus Atg8 homologs xLC3B and xGATE16. xAtg4B-mediated tag cleavage is very robust in solution or on-column, efficient at 4°C and orthogonal to TEV protease and the recently introduced proteases bdSENP1, bdNEDP1 and xUsp2. Importantly, xLC3B fusions are stable in wheat germ extract or when expressed in Saccharomyces cerevisiae, but cleavable by xAtg4B during or following purification. We also found that fusions to the bdNEDP1 substrate bdNEDD8 are stable in S. cerevisiae. In combination, or findings now provide a system, where proteins and complexes fused to xLC3B or bdNEDD8 can be expressed in a eukaryotic host and purified by successive affinity capture and proteolytic release steps.

  18. A natural Poincare gauge model

    International Nuclear Information System (INIS)

    Aldrovandi, R.; Pereira, J.G.

    1985-01-01

    A natural candidate model for a gauge theory for the Poincare group is discussed. It satisfies the usual electric-magnetic symmetry of gauge models and is a contraction of a gauge model for the De Sitter group. Its field equations are just the Yang-Mills equations for the Poincare group. It is shown that these equations do not follow from a Lagrangean. (Author) [pt

  19. Stochastic quantization and gauge theories

    International Nuclear Information System (INIS)

    Kolck, U. van.

    1987-01-01

    Stochastic quantization is presented taking the Flutuation-Dissipation Theorem as a guide. It is shown that the original approach of Parisi and Wu to gauge theories fails to give the right results to gauge invariant quantities when dimensional regularization is used. Although there is a simple solution in an abelian theory, in the non-abelian case it is probably necessary to start from a BRST invariant action instead of a gauge invariant one. Stochastic regularizations are also discussed. (author) [pt

  20. Comments on General Gauge Mediation

    OpenAIRE

    Intriligator, Kenneth; Sudano, Matthew

    2008-01-01

    There has been interest in generalizing models of gauge mediation of supersymmetry breaking. As shown by Meade, Seiberg, and Shih (MSS), the soft masses of general gauge mediation can be expressed in terms of the current two-point functions of the susy-breaking sector. We here give a simple extension of their result which provides, for general gauge mediation, the full effective potential for squark pseudo-D-flat directions. The effective potential reduces to the sfermion soft masses near the...

  1. Gravitation and Gauge Symmetries

    CERN Document Server

    Stewart, J

    2002-01-01

    The purpose of this book (I quote verbatim from the back cover) is to 'shed light upon the intrinsic structure of gravity and the principle of gauge invariance, which may lead to a consistent unified field theory', a very laudable aim. The content divides fairly clearly into four sections (and origins). After a brief introduction, chapters 2-6 review the 'Structure of gravity as a theory based on spacetime gauge symmetries'. This is fairly straightforward material, apparently based on a one-semester graduate course taught at the University of Belgrade for about two decades, and, by implication, this is a reasonably accurate description of its level and assumed knowledge. There follow two chapters of new material entitled 'Gravity in flat spacetime' and 'Nonlinear effects in gravity'. The final three chapters, entitled 'Supersymmetry and supergravity', 'Kaluza-Klein theory' and 'String theory' have been used for the basis of a one-semester graduate course on the unification of fundamental interactions. The boo...

  2. Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis.

    Science.gov (United States)

    Li, Huiyan; Peng, Xuan; Wang, Yating; Cao, Shirong; Xiong, Liping; Fan, Jinjin; Wang, Yihan; Zhuang, Shougang; Yu, Xueqing; Mao, Haiping

    2016-09-01

    Macroautophagy/autophagy protects against cellular stress. Renal sublethal injury-triggered tubular epithelial cell cycle arrest at G2/M is associated with interstitial fibrosis. However, the role of autophagy in renal fibrosis is elusive. Here, we hypothesized that autophagy activity in tubular epithelial cells is pivotal for inhibition of cell cycle G2/M arrest and subsequent fibrogenic response. In both renal epithelial cells stimulated by angiotensin II (AGT II) and the murine kidney after unilateral ureteral obstruction (UUO), we observed that occurrence of autophagy preceded increased production of COL1 (collagen, type I). Pharmacological enhancement of autophagy by rapamycin suppressed COL1 accumulation and renal fibrosis. In contrast, genetic ablation of autophagy by proximal tubular epithelial cell-specific deletion of Atg5, with reduction of the LC3-II protein level and degradation of SQSTM1/p62, showed marked cell cycle arrest at the G2/M phase, robust COL1 deposition, and severe interstitial fibrosis in a UUO model, as compared with wild-type mice. In vitro, AGT II exposure triggered autophagy preferentially in the G1/S phase, and increased COL1 expression in the G2/M phase in renal epithelial cells. Stimulation of Atg5-deficient primary proximal tubular cells with AGT II also resulted in elevated G2/M arrest and COL1 production. Pharmacological or genetic inhibition of autophagy increased AGT II-mediated G2/M arrest. Enhanced expression of ATG5, but not the autophagy-deficient ATG5 mutant K130R, rescued the G2/M arrest, suggesting the regulation of cell cycle progression by ATG5 is autophagy dependent. In conclusion, Atg5-mediated autophagy in proximal epithelial cells is a critical host-defense mechanism that prevents renal fibrosis by blocking G2/M arrest.

  3. Gauges for fine and high vacuum

    CERN Document Server

    Jousten, K

    2007-01-01

    Vacuum gauges for use in accelerators have to cover about 17 decades of pressure, from 10–12 Pa to 105 Pa. In this article we describe the history, measurement mode, design, accuracy and calibration of the gauges used down to 10–5 Pa. We focus on commercially available types of gauges, i.e., mechanical gauges, piezoresistive and capacitance diaphragm gauges, thermal conductivity gauges, and spinning rotor gauges.

  4. ANALYSIS OF THE ACCURACY OF FIBRE-OPTIC STRAIN GAUGES

    Directory of Open Access Journals (Sweden)

    Dita Jiroutová

    2013-12-01

    Full Text Available In recent years, the field of structure monitoring has been making increasing use of systems based on fiber-optic technologies. Fiber-optic technology offers many advantages, including higher quality measurements, greater reliability, easier installation and maintenance, insensitivity to the environment (mainly to the electromagnetic field, corrosion resistance, safety in explosive and flammable environments, the possibility of long-term monitoring and lower cost per lifetime. We have used SOFO fibre-optic strain gauges to perform measurements to check the overall relative deformation of a real reinforced concrete structure. Long-term monitoring of the structure revealed that the measurement readings obtained from these fibre-optic strain gauges differed from each other. Greater attention was therefore paid to the calibration of the fibre-optic strain gauges, and to determining their measurement accuracy. The experimental results show that it is necessary to calibrate SOFO strain gauges before they are used, and to determine their calibration constant.

  5. Gauged U(1) clockwork theory

    Science.gov (United States)

    Lee, Hyun Min

    2018-03-01

    We consider the gauged U (1) clockwork theory with a product of multiple gauge groups and discuss the continuum limit of the theory to a massless gauged U (1) with linear dilaton background in five dimensions. The localization of the lightest state of gauge fields on a site in the theory space naturally leads to exponentially small effective couplings of external matter fields localized away from the site. We discuss the implications of our general discussion with some examples, such as mediators of dark matter interactions, flavor-changing B-meson decays as well as D-term SUSY breaking.

  6. Residual gauge invariance of Hamiltonian lattice gauge theories

    International Nuclear Information System (INIS)

    Ryang, S.; Saito, T.; Shigemoto, K.

    1984-01-01

    The time-independent residual gauge invariance of Hamiltonian lattice gauge theories is considered. Eigenvalues and eigenfunctions of the unperturbed Hamiltonian are found in terms of Gegengauer's polynomials. Physical states which satisfy the subsidiary condition corresponding to Gauss' law are constructed systematically. (orig.)

  7. An Intelligent Strain Gauge with Debond Detection and Temperature Compensation

    Science.gov (United States)

    Jensen, Scott L.

    2012-01-01

    The harsh rocket propulsion test environment will expose any inadequacies associated with preexisting instrumentation technologies, and the criticality for collecting reliable test data justifies investigating any encountered data anomalies. Novel concepts for improved systems are often conceived during the high scrutiny investigations by individuals with an in-depth knowledge from maintaining critical test operations. The Intelligent Strain Gauge concept was conceived while performing these kinds of activities. However, the novel concepts are often unexplored even if it has the potential for advancing the current state of the art. Maturing these kinds of concepts is often considered to be a tangential development or a research project which are both normally abandoned within the propulsion-oriented environment. It is also difficult to justify these kinds of projects as a facility enhancement because facility developments are only accepted for mature and proven technologies. Fortunately, the CIF program has provided an avenue for bringing the Intelligent Strain Gauge to fruition. Two types of fully functional smart strain gauges capable of performing reliable and sensitive debond detection have been successfully produced. Ordinary gauges are designed to provide test article data and they lack the ability to supply information concerning the gauge itself. A gauge is considered to be a smart gauge when it provides supplementary data relating other relevant attributes for performing diagnostic function or producing enhanced data. The developed strain gauges provide supplementary signals by measuring strain and temperature through embedded Karma and nickel chromium (NiCr) alloy elements. Intelligently interpreting the supplementary data into valuable information can be performed manually, however, integrating this functionality into an automatic system is considered to be an intelligent gauge. This was achieved while maintaining a very low mass. The low mass enables

  8. Science Technology Engineering and Math (STEM) Education MUST Begin in Early Childhood Education: A Systematic Analysis of Washington State Guidelines Used to Gauge the Development and Learning of Young Learners

    Science.gov (United States)

    Briseno, Luis Miguel

    This paper reflects future direction for early Science Technology Engineering and Mathematics (STEM) education, science in particular. Washington State stakeholders use guidelines including: standards, curriculums and assessments to gauge young children's development and learning, in early childhood education (ECE). Next Generation Science Standards (NGSS), and the Framework for K-12 programs (National Research Council, 2011) emphasizes the need for reconfiguration of standards: "Too often standards are a long list of detailed and disconnected facts... this approach alienates young people, it also leaves them with fragments of knowledge and little sense of the inherent logic and consistency of science and of its universality." NGSS' position elevates the concern and need for learners to experience teaching and learning from intentionally designed cohesive curriculum units, rather than as a series of unrelated and isolated lessons. To introduce the argument the present study seeks to examine Washington State early learning standards. To evaluate this need, I examined balance and coverage/depth. Analysis measures the level of continuum in high-quality guidelines from which Washington State operates to serve its youngest citizens and their families.

  9. ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes

    NARCIS (Netherlands)

    Meijer, Wiebe H.; Klei, Ida J. van der; Veenhuis, Marten; Kiel, Jan A.K.W.

    2007-01-01

    ATG genes encode proteins that are required for macroautophagy, the Cvt pathway and/or pexophagy. Using the published Atg protein sequences, we have screened protein and DNA databases to identify putative functional homologs (orthologs) in 21 fungal species (yeast and filamentous fungi) of which the

  10. WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.

    Science.gov (United States)

    Dooley, Hannah C; Razi, Minoo; Polson, Hannah E J; Girardin, Stephen E; Wilson, Michael I; Tooze, Sharon A

    2014-07-17

    Mammalian cell homeostasis during starvation depends on initiation of autophagy by endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns(3)P) synthesis. Formation of double-membrane autophagosomes that engulf cytosolic components requires the LC3-conjugating Atg12-5-16L1 complex. The molecular mechanisms of Atg12-5-16L1 recruitment and significance of PtdIns(3)P synthesis at autophagosome formation sites are unknown. By identifying interacting partners of WIPIs, WD-repeat PtdIns(3)P effector proteins, we found that Atg16L1 directly binds WIPI2b. Mutation experiments and ectopic localization of WIPI2b to plasma membrane show that WIPI2b is a PtdIns(3)P effector upstream of Atg16L1 and is required for LC3 conjugation and starvation-induced autophagy through recruitment of the Atg12-5-16L1 complex. Atg16L1 mutants, which do not bind WIPI2b but bind FIP200, cannot rescue starvation-induced autophagy in Atg16L1-deficient MEFs. WIPI2b is also required for autophagic clearance of pathogenic bacteria. WIPI2b binds the membrane surrounding Salmonella and recruits the Atg12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  11. On the dynamics of gauge potential

    International Nuclear Information System (INIS)

    Tao Jiafu; Li Yuanjie; Zhang Jinru

    1992-01-01

    The gauge potential is resolved into gauge potential of strength and gauge potential of phase. The phase gauge potential can be described with an equivalent potential of inertial force. A Lagrangian density with phase gauge potential is given and some examples are discussed. The method proposed has been extended to the case of the non-Abelian group

  12. Gauged Lepton Flavour

    CERN Document Server

    Alonso, R.; Gavela, M.B.; Grinstein, B.; Merlo, L.; Quilez, P.

    2016-12-22

    The gauging of the lepton flavour group is considered in the Standard Model context and in its extension with three right-handed neutrinos. The anomaly cancellation conditions lead to a Seesaw mechanism as underlying dynamics for all leptons; requiring in addition a phenomenologically viable setup leads to Majorana masses for the neutral sector: the type I Seesaw Lagrangian in the Standard Model case and the inverse Seesaw in the extended model. Within the minimal extension of the scalar sector, the Yukawa couplings are promoted to scalar fields in the bifundamental of the flavour group. The resulting low-energy Yukawa couplings are proportional to inverse powers of the vacuum expectation values of those scalars; the protection against flavour changing neutral currents differs from that of Minimal Flavor Violation. In all cases, the $\\mu-\\tau$ flavour sector exhibits rich and promising phenomenological signals.

  13. Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration.

    Science.gov (United States)

    Yi, Cong; Tong, Jingjing; Lu, Puzhong; Wang, Yizheng; Zhang, Jinxie; Sun, Chen; Yuan, Kangning; Xue, Renyu; Zou, Bing; Li, Nianzhong; Xiao, Shuhua; Dai, Chong; Huang, Yuwei; Xu, Liling; Li, Lin; Chen, She; Miao, Di; Deng, Haiteng; Li, Hongliang; Yu, Li

    2017-04-10

    Autophagy is essential for maintaining glucose homeostasis, but the mechanism by which energy deprivation activates autophagy is not fully understood. We show that Mec1/ATR, a member of the DNA damage response pathway, is essential for glucose starvation-induced autophagy. Mec1, Atg13, Atg1, and the energy-sensing kinase Snf1 are recruited to mitochondria shortly after glucose starvation. Mec1 is recruited through the adaptor protein Ggc1. Snf1 phosphorylates Mec1 on the mitochondrial surface, leading to recruitment of Atg1 to mitochondria. Furthermore, the Snf1-mediated Mec1 phosphorylation and mitochondrial recruitment of Atg1 are essential for maintaining mitochondrial respiration during glucose starvation, and active mitochondrial respiration is required for energy deprivation-activated autophagy. Thus, formation of a Snf1-Mec1-Atg1 module on mitochondria governs energy deprivation-induced autophagy by regulating mitochondrial respiration. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Physics from multidimensional gauge theories

    International Nuclear Information System (INIS)

    Forgacs, P.; Lust, D.; Zoupanos, G.

    1986-01-01

    The authors motivate high dimensional theories by recalling the original Kaluza-Klein proposal. They review the dimensional reduction of symmetric gauge theories and they present the results of the attempts to obtain realistic description of elementary particles interactions starting from symmetric gauge theories in high dimensions

  15. Gauging away a big bang

    Science.gov (United States)

    Krishnan, Chethan; Raju, Avinash

    2017-08-01

    We argue that in the tensionless phase of string theory where the stringy gauge symmetries are unbroken, (at least some) cosmological singularities can be understood as gauge artefacts. We present two conceptually related, but distinct, pieces of evidence: one relying on spacetime and the other on worldsheet.

  16. Introduction to gauge field theory

    International Nuclear Information System (INIS)

    Bailin, David; Love, Alexander

    1986-01-01

    The book is intended as an introduction to gauge field theory for the postgraduate student of theoretical particle physics. The topics discussed in the book include: path integrals, classical and quantum field theory, scattering amplitudes, feynman rules, renormalisation, gauge field theories, spontaneous symmetry breaking, grand unified theory, and field theories at finite temperature. (UK)

  17. Gauge and supergauge field theories

    International Nuclear Information System (INIS)

    Slavnov, A.

    1977-01-01

    The most actual problems concerning gauge fields are reviwed. Theoretical investigations conducted since as early as 1954 are enclosed. Present status of gauge theories is summarized, including intermediate vector mesons, heavy leptons, weak interactions of hadrons, V-A structure, universal interaction, infrared divergences in perturbation theory, particle-like solutions in gauge theories, spontaneous symmetry breaking. Special emphasis is placed on strong interactions, or more precisely, on the alleged unobservability of ''color'' objects (quark confinement). Problems dealing with the supersymmetric theories invariant under gauge transformations and spontaneous breaking of supersymmetry are also discussed. Gauge theories are concluded to provide self-consistent apparatus for weak and electromagnetic interactions. As to strong interactions such models are still to be discovered

  18. Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study.

    Directory of Open Access Journals (Sweden)

    Monica Grafals

    Full Text Available Rabbit antithymocyte globulin (ATG is commonly used as an induction therapy in renal transplant recipients, but the ideal dosage in tacrolimus-based early steroid withdrawal protocols has not been established. The purpose of this pilot study was to determine the immunophenotyping and efficacy of lower dose ATG in low immunological-risk kidney transplant recipients. In this prospective study, 45 patients were randomized (1∶1 to our standard dose ATG (total dose 3.75 mg/kg(sATG vs. lower dose 2.25 mg/kg (lowATG. All patients underwent early steroid withdrawal within 7 days. The primary end point was biopsy-proven acute rejection at 12 months. Prospective immunophenotyping of freshly isolated PBMCs was performed at baseline, 3, 6, 12 months post-transplant. The rate of acute rejection was 17% and 10% in the sATG and lowATG, respectively. Effector memory T cells, Tregs and recent thymic emigrants T cells had similar kinetics post-transplant in both groups. No statistically significant differences were found in graft survival, patient survival or infections between the two groups, though there was a non-significant increase in leukopenia (43%v s. 30%, CMV (8% vs. 0 and BK (4% vs. 0 infections in sATG group vs. lowATG. In sum, in low immunological risk kidney recipients undergoing steroid withdrawal, low dose ATG seems to be efficacious in preventing acute rejection and depleting T cells with potentially lower infectious complications. A larger study is warranted to confirm these findings.ClinicalTrials.gov NCT00548405.

  19. Atomic Energy Act (AtG) and subordinate legislation. Collections. 35. ed.

    International Nuclear Information System (INIS)

    Ziegler, Eberhard

    2018-01-01

    The Atomic Energy Act (AtG) and subordinate legislation covers the following issues: The German constitution, the atomic energy act, subordinate process regulations, radiation protection regulation, X-ray regulation, financial security regulation, cost regulations, safety delegate and reporting regulations, law on the installation of a Federal Office for nuclear disposal security, site selection law, final repository advance financing, radioactive waste transport regulation, disposal fund law, regulation on the payment receipt according to the disposal fund law, transitional disposal law, transparency law, run-off liability law, law on the installation of the Federal office for radiation protection, radiation protection law, food irradiation law, regulation on drug treatment with radioactivity or ionizing radiation, Paris agreement on nuclear liabilities and additional agreement, joint protocol on the application of the Vienna and Paris agreements, environmental compatibility assessment law, criminal code (partial), state competence regulations on the execution of regulations according the atomic energy act.

  20. The Atg8 Family of Proteins—Modulating Shape and Functionality of Autophagic Membranes

    Directory of Open Access Journals (Sweden)

    Iman Abdollahzadeh

    2017-08-01

    Full Text Available Aging is a multifactorial process involving an accumulation of alterations on various organizational levels, which finally compromises viability and limits the lifespan of organisms. It is now well-established that many aspects of aging can be positively affected by (macroautophagy, a mechanism of self-digestion found in virtually all eukaryotic cells. A comprehensive understanding of autophagy is thus expected to not only deepen our insight into the mechanisms of aging but to also open up new avenues toward increasing the healthy lifespan in humans. In this review, we focus on the Atg8 family of ubiquitin-like proteins, which play a crucial role in the autophagy process by virtue of their unique mode of reversible membrane association.

  1. The Atg8 Family of Proteins—Modulating Shape and Functionality of Autophagic Membranes

    Science.gov (United States)

    Abdollahzadeh, Iman; Schwarten, Melanie; Gensch, Thomas; Willbold, Dieter; Weiergräber, Oliver H.

    2017-01-01

    Aging is a multifactorial process involving an accumulation of alterations on various organizational levels, which finally compromises viability and limits the lifespan of organisms. It is now well-established that many aspects of aging can be positively affected by (macro)autophagy, a mechanism of self-digestion found in virtually all eukaryotic cells. A comprehensive understanding of autophagy is thus expected to not only deepen our insight into the mechanisms of aging but to also open up new avenues toward increasing the healthy lifespan in humans. In this review, we focus on the Atg8 family of ubiquitin-like proteins, which play a crucial role in the autophagy process by virtue of their unique mode of reversible membrane association. PMID:28894458

  2. The Atg8 Family of Proteins-Modulating Shape and Functionality of Autophagic Membranes.

    Science.gov (United States)

    Abdollahzadeh, Iman; Schwarten, Melanie; Gensch, Thomas; Willbold, Dieter; Weiergräber, Oliver H

    2017-01-01

    Aging is a multifactorial process involving an accumulation of alterations on various organizational levels, which finally compromises viability and limits the lifespan of organisms. It is now well-established that many aspects of aging can be positively affected by (macro)autophagy, a mechanism of self-digestion found in virtually all eukaryotic cells. A comprehensive understanding of autophagy is thus expected to not only deepen our insight into the mechanisms of aging but to also open up new avenues toward increasing the healthy lifespan in humans. In this review, we focus on the Atg8 family of ubiquitin-like proteins, which play a crucial role in the autophagy process by virtue of their unique mode of reversible membrane association.

  3. Atomic Energy Act (AtG) and subordinate legislation. Collections. 35. ed.; Atomgesetz mit Verordnungen. Textsammlung

    Energy Technology Data Exchange (ETDEWEB)

    Ziegler, Eberhard (ed.)

    2018-03-01

    The Atomic Energy Act (AtG) and subordinate legislation covers the following issues: The German constitution, the atomic energy act, subordinate process regulations, radiation protection regulation, X-ray regulation, financial security regulation, cost regulations, safety delegate and reporting regulations, law on the installation of a Federal Office for nuclear disposal security, site selection law, final repository advance financing, radioactive waste transport regulation, disposal fund law, regulation on the payment receipt according to the disposal fund law, transitional disposal law, transparency law, run-off liability law, law on the installation of the Federal office for radiation protection, radiation protection law, food irradiation law, regulation on drug treatment with radioactivity or ionizing radiation, Paris agreement on nuclear liabilities and additional agreement, joint protocol on the application of the Vienna and Paris agreements, environmental compatibility assessment law, criminal code (partial), state competence regulations on the execution of regulations according the atomic energy act.

  4. Toxoplasma gondii autophagy-related protein ATG9 is crucial for the survival of parasites in their host.

    Science.gov (United States)

    Nguyen, Hoa Mai; El Hajj, Hiba; El Hajj, Rana; Tawil, Nadim; Berry, Laurence; Lebrun, Maryse; Bordat, Yann; Besteiro, Sébastien

    2017-06-01

    Autophagy is a conserved, life-promoting, catabolic process involved in the recycling of nonessential cellular components in response to stress. The parasite Toxoplasma gondii is an early-diverging eukaryote in which part of the autophagy machinery is not exclusively involved in a catabolic process but instead has been repurposed for an original function in organelle inheritance during cell division. This function, depending essentially on protein TgATG8 and its membrane conjugation system, is crucial for parasite survival and prevented an in depth study of autophagy in the mutants generated so far in Toxoplasma. Thus, in order to decipher the primary function of canonical autophagy in the parasites, we generated a cell line deficient for TgATG9, a protein thought to be involved in the early steps of the autophagy process. Although the protein proved to be dispensable for the development of these obligate intracellular parasites in vitro, the absence of TgATG9 led to a reduced ability to sustain prolonged extracellular stress. Importantly, depletion of the protein significantly reduced parasites survival in macrophages and markedly attenuated their virulence in mice. Altogether, this shows TgATG9 is important for the fate of Toxoplasma in immune cells and contributes to the overall virulence of the parasite, possibly through an involvement in a canonical autophagy pathway. © 2016 John Wiley & Sons Ltd.

  5. 46 CFR 154.1370 - Pressure gauge and vacuum gauge marking.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Pressure gauge and vacuum gauge marking. 154.1370... Equipment Instrumentation § 154.1370 Pressure gauge and vacuum gauge marking. Each pressure gauge and vacuum gauge under § 154.1335(a) must be marked with the maximum and minimum pressures that are specified on...

  6. What's wrong with anomalous chiral gauge theory?

    International Nuclear Information System (INIS)

    Kieu, T.D.

    1994-05-01

    It is argued on general ground and demonstrated in the particular example of the Chiral Schwinger Model that there is nothing wrong with apparently anomalous chiral gauge theory. If quantised correctly, there should be no gauge anomaly and chiral gauge theory should be renormalisable and unitary, even in higher dimensions and with non-Abelian gauge groups. Furthermore, it is claimed that mass terms for gauge bosons and chiral fermions can be generated without spoiling the gauge invariance. 19 refs

  7. Gauge and non-gauge curvature tensor copies

    International Nuclear Information System (INIS)

    Srivastava, P.P.

    1982-10-01

    A procedure for constructing curvature tensor copies is discussed using the anholonomic geometrical framework. The corresponding geometries are compared and the notion of gauge copy is elucidated. An explicit calculation is also made. (author)

  8. En-gauging naturalness

    Energy Technology Data Exchange (ETDEWEB)

    Bharucha, Aoife [Hamburg Univ. (Germany). II. Inst. fuer Theoretische Physik; Technische Univ. Muenchen, Garching (Germany). Physik-Dept. T31; Goudelis, Andreas [Savoie Univ., CNRS, Annecy-le-Vieux (France). LAPTh; McGarrie, Moritz [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2013-10-15

    The discovery of a 125.5 GeV Higgs with standard model-like couplings and naturalness considerations motivate gauge extensions of the MSSM. We analyse two variants of such an extension and carry out a phenomenological study of regions of the parameter space statisfying current direct and indirect constraints, employing state-of-the-art two-loop RGE evolution and GMSB boundary conditions. We find that due to the appearance of non-decoupled D-terms it is possible to obtain a 125.5 GeV Higgs with stops below 2 TeV, while the uncolored sparticles could still lie within reach of the LHC. We compare the contributions of the stop sector and the non-decoupled D-terms to the Higgs mass, and study their effect on the Higgs couplings. We further investigate the nature of the next-to lightest supersymmetric particle, in light of the GMSB motivated searches currently being pursued by ATLAS and CMS.

  9. Lattice calculations in gauge theory

    International Nuclear Information System (INIS)

    Rebbi, C.

    1985-01-01

    The lattice formulation of quantum gauge theories is discussed as a viable technique for quantitative studies of nonperturbative effects in QCD. Evidence is presented to ascertain that whole classes of lattice actions produce a universal continuum limit. Discrepancies between numerical results from Monto Carlo simulations for the pure gauge system and for the system with gauge and quark fields are discussed. Numerical calculations for QCD require very substantial computational resources. The use of powerful vector processors of special purpose machines, in extending the scope and magnitude or the calculations is considered, and one may reasonably expect that in the near future good quantitative predictions will be obtained for QCD

  10. Gauge theories in particle physics

    International Nuclear Information System (INIS)

    Taylor, J.

    1993-01-01

    Forces and the background theory, special relativity, space-time and quantum theory are first reviewed and linked in particles physics (relativity plus quantum theory); spin in quantum mechanics is then detailed and electromagnetism is explained with the view of the generalization of the gauge aspect of electromagnetism; gauge fields interacting with leptons and quarks, short-range forces from gauge theories, the high-energy limit, strong interactions, electric and magnetic properties of matter, vacuum polarization and asymptotic freedom, confinement, are also discussed. 29 figs

  11. BRST gauge fixing and regularization

    International Nuclear Information System (INIS)

    Damgaard, P.H.; Jonghe, F. de; Sollacher, R.

    1995-05-01

    In the presence of consistent regulators, the standard procedure of BRST gauge fixing (or moving from one gauge to another) can require non-trivial modifications. These modifications occur at the quantum level, and gauges exist which are only well-defined when quantum mechanical modifications are correctly taken into account. We illustrate how this phenomenon manifests itself in the solvable case of two-dimensional bosonization in the path-integral formalism. As a by-product, we show how to derive smooth bosonization in Batalin-Vilkovisky Lagrangian BRST quantization. (orig.)

  12. Genome-wide analysis of autophagy-related genes in banana highlights MaATG8s in cell death and autophagy in immune response to Fusarium wilt.

    Science.gov (United States)

    Wei, Yunxie; Liu, Wen; Hu, Wei; Liu, Guoyin; Wu, Chunjie; Liu, Wei; Zeng, Hongqiu; He, Chaozu; Shi, Haitao

    2017-08-01

    MaATG8s play important roles in hypersensitive-like cell death and immune response, and autophagy is essential for disease resistance against Foc in banana. Autophagy is responsible for the degradation of damaged cytoplasmic constituents in the lysosomes or vacuoles. Although the effects of autophagy have been extensively revealed in model plants, the possible roles of autophagy-related gene in banana remain unknown. In this study, 32 MaATGs were identified in the draft genome, and the profiles of several MaATGs in response to fungal pathogen Fusarium oxysporum f. sp. cubense (Foc) were also revealled. We found that seven MaATG8s were commonly regulated by Foc. Through transient expression in Nicotiana benthamiana leaves, we highlight the novel roles of MaATG8s in conferring hypersensitive-like cell death, and MaATG8s-mediated hypersensitive response-like cell death is dependent on autophagy. Notablly, autophagy inhibitor 3-methyladenine (3-MA) treatment resulted in decreased disease resistance in response to Foc4, and the effect of 3-MA treatment could be rescued by exogenous salicylic acid, jasmonic acid and ethylene, indicating the involvement of autophagy-mediated plant hormones in banana resistance to Fusarium wilt. Taken together, this study may extend our understanding the putative role of MaATG8s in hypersensitive-like cell death and the essential role of autophagy in immune response against Foc in banana.

  13. CogGauge, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Cog-Gauge is a portable hand-held game that can be used by astronauts and crew members during space exploration missions to assess their cognitive workload...

  14. Spectroscopy of family gauge bosons

    Directory of Open Access Journals (Sweden)

    Yoshio Koide

    2014-09-01

    Full Text Available Spectroscopy of family gauge bosons is investigated based on a U(3 family gauge boson model proposed by Sumino. In his model, the family gauge bosons are in mass eigenstates in a diagonal basis of the charged lepton mass matrix. Therefore, the family numbers are defined by (e1,e2,e3=(e,μ,τ, while the assignment for quark sector are free. For possible family-number assignments (q1,q2,q3, under a constraint from K0–K¯0 mixing, we investigate possibilities of new physics, e.g. production of the lightest family gauge boson at the LHC, μ−N→e−N, rare K and B decays, and so on.

  15. Symmetry gauge theory for paraparticles

    International Nuclear Information System (INIS)

    Kursawe, U.

    1986-01-01

    In the present thesis it was shown that for identical particles the wave function of which has a more complicated symmetry than it is the case at the known kinds of particles, the bosons and fermions, a gauge theory can be formulated, the so-called 'symmetry gauge theory'. This theory has its origin alone in the symmetry of the particle wave functions and becomes first relevant when more than two particles are considered. It was shown that for particles with mixed-symmetrical wave functions, so-called 'paraparticles', the quantum mechanical state is no more described by one Hilbert-space element but by a many-dimensional subspace of this Hilbert space. The gauge freedom consists then just in the freedom of the choice of the basis in this subspace, the corresponding gauge group is the group of the unitary basis transformation in this subspace. (orig./HSI) [de

  16. Radiative processes in gauge theories

    International Nuclear Information System (INIS)

    Berends, F.A.; Kleiss, R.; Danckaert, D.; Causmaecker, P. De; Gastmans, R.; Troost, W.; Tai Tsun Wu

    1982-01-01

    It is shown how the introduction of explicit polarization vectors of the radiated gauge particles leads to great simplifications in the calculation of bremsstrahlung processes at high energies. (author)

  17. Gauge theories in particle physics

    International Nuclear Information System (INIS)

    Aitchison, I.J.R.; Hey, A.J.G.

    1982-01-01

    The first theory, quantum electrodynamics (QED) is known to give a successful account of electromagnetic interactions. Weak and strong interactions are described by gauge theories which are generalisations of QED. The electro-weak gauge theory of Glashow Salam and Weinberg unites electromagnetic and weak interactions. Quantum chromodynamics (QCD) is the gauge theory of strong interactions. This approach to these theories, designed for the non-specialist, is based on a straightforward generalisation of non-relativistic quantum-mechanical perturbation theory to the relativistic case, leading to an intuitive introduction to Feynman graphs. Spontaneously broken-or 'hidden'-symmetries are given particular attention, with the physics of hidden gauge invariance and the role of the vacuum (essential to the unified theories) being illustrated by an extended but elementary discussion of the non-relativistic example of superconductivity. Throughout, emphasis is placed both on realistic calculations and on physical understanding. (author)

  18. Optical Rain Gauge Instrument Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Bartholomew, Mary Jane [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-04-01

    To improve the quantitative description of precipitation processes in climate models, the U.S. Department of Energy (DOE)’s Atmospheric Radiation Measurement (ARM) Climate Research Facility deploys several types of rain gauges (MET, RAIN, and optical rain gauge [ORG] datastreams) as well as disdrometers (DISD and VDIS datastreams) at the Southern Great Plains (SGP) Site. This handbook deals specifically with the independent analog ORG (i.e., the ORG datastream).

  19. Model of unified gauge fields

    International Nuclear Information System (INIS)

    Leite Lopes, J.

    1998-04-01

    In this work, we discuss the physical ideas which represents the basis for the unified gauge field model. Despite of the difficulties that we presently have for embodying in a natural manner muons and hadrons in that model, we have the feeling that we are on the way which seems to lead to the construction of a theory in which the Maxwell electromagnetic field and the Fermi weak interaction field are manifestations of a unique subjacent physical entity - the unified gauge fields. (author)

  20. 49 CFR 230.43 - Gauge siphon.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Gauge siphon. 230.43 Section 230.43 Transportation... TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Boilers and Appurtenances Steam Gauges § 230.43 Gauge siphon. The steam gauge supply pipe shall have a siphon on it of ample capacity to prevent...

  1. 49 CFR 229.107 - Pressure gauge.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Pressure gauge. 229.107 Section 229.107....107 Pressure gauge. (a) Each steam generator shall have an illuminated steam gauge that correctly indicates the pressure. The steam pressure gauge shall be graduated to not less than one and one-half times...

  2. Current algebra for chiral gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Manias, M.V.; von Reichenbach, M.C.; Schaposnik, F.A.; Trobo, M.

    1987-07-01

    Chiral gauge theories are studied with a special emphasis on the treatment of gauge degrees of freedom so as to obtain a gauge-invariant effective action from which current commutators can be evaluated. It is explicitly shown in a simple example that these commutators are those to be expected in a gauge-invariant theory.

  3. Performance of modern tide gauges: towards mm-level accuracy

    Directory of Open Access Journals (Sweden)

    Belén Martín Míguez

    2012-09-01

    Full Text Available Considerable efforts are being made worldwide to upgrade tide gauge networks using new technologies. Because of the unique location of the Kerguelen Islands, the measurement of sea level there has received particular attention, with up to four systems equipped with modern sensors functioning simultaneously (two pressure tide gauges, a radar tide gauge, and a GPS-equipped buoy. We analysed and compared the sea level data obtained with these systems from 2003 to 2010, together with a time series of tide pole observations. This is the first time that a multi-comparison study with tide gauges has been undertaken over such a long time span and that the stability of modern radar tide gauges has been examined. The multi-comparison enabled us to evaluate the performance of the tide gauges in several frequency ranges, identify errors and estimate their magnitude. The drift of the pressure sensors (up to 8.0 mm/yr was found to be one of the most relevant sources of systematic error. Other sources of difference such as clock drift, scale error and different locations of the instruments were also detected. After correcting the time series of sea level for these errors we estimated an upper bound for the radar instrumental error in field condition at ~0.3 cm.

  4. Correction of Gauge Factor for Strain Gauges Used in Polymer Composite Testing

    DEFF Research Database (Denmark)

    Zike, Sanita; Mikkelsen, Lars Pilgaard

    2014-01-01

    Strain gauges are used together with the corresponding gauge factor to relate the relative electrical resistance change of the strain gauge with the strain of the underlying material. The gauge factor is found from a calibration on a stiff material - steel. Nevertheless, the gauge factor depends ...... ranging from 1 GPa to 200 GPa....

  5. The photon propagator in the Poincare gauge

    Energy Technology Data Exchange (ETDEWEB)

    Barcelos-Neto, J. (Univ. Federal do Rio de Janeiro, Inst. de Fisica (Brazil)); Galvao, C.A.P.; Gaete, P. (Centro Brasileiro de Pesquisas Fisicas, CBPF/CNPq, Rio de Janeiro (Brazil))

    1991-07-22

    After a brief analysis of the covariant gauge condition known as the Fock-Schwinger gauge, we establish its corresponding non-covariant version which we call the Poincare gauge. Using the path integral formalism, within the Senjanovic framework, we calculate the photon propagator in this gauge. Some formal similarities between our results and the expressions for the photon propagator in the Coulomb gauge are pointed out. (orig.).

  6. String field theory in the Siegel gauge

    International Nuclear Information System (INIS)

    Bochicchio, M.

    1987-01-01

    We specialize the gauge-fixing procedure for the Witten action of the open bosonic string, given in a preceding paper, choosing the Siegel gauge. We find that the BRST-invariant gauge-fixed action is the gauge invariant one with ghost number unrestricted plus a gauge-fixing term. The BRST invariance of the measure in the functional integral is briefly discussed. As a technical tool the Hodge dual of a string functional is defined. (orig.)

  7. Invariance, symmetry and periodicity in gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Jackiw, R

    1980-02-01

    The interplay between gauge transformations and coordinate transformations is discussed; the theory will aid in understanding the mixing of space-time and internal degrees of freedom. The subject is presented under the following headings: coordinate transformation laws for arbitrary fields, coordinate transformation laws for gauge fields, properties of symmetric gauge fields, construction of symmetric gauge fields, physical significance of gauge transformations, and magnetic monopole topology without Higgs fields. The paper ends with conclusions and suggestions for further research. (RWR)

  8. AP-4 mediates export of ATG9A from thetrans-Golgi network to promote autophagosome formation.

    Science.gov (United States)

    Mattera, Rafael; Park, Sang Yoon; De Pace, Raffaella; Guardia, Carlos M; Bonifacino, Juan S

    2017-12-12

    AP-4 is a member of the heterotetrameric adaptor protein (AP) complex family involved in protein sorting in the endomembrane system of eukaryotic cells. Interest in AP-4 has recently risen with the discovery that mutations in any of its four subunits cause a form of hereditary spastic paraplegia (HSP) with intellectual disability. The critical sorting events mediated by AP-4 and the pathogenesis of AP-4 deficiency, however, remain poorly understood. Here we report the identification of ATG9A, the only multispanning membrane component of the core autophagy machinery, as a specific AP-4 cargo. AP-4 promotes signal-mediated export of ATG9A from the trans -Golgi network to the peripheral cytoplasm, contributing to lipidation of the autophagy protein LC3B and maturation of preautophagosomal structures. These findings implicate AP-4 as a regulator of autophagy and altered autophagy as a possible defect in AP-4-deficient HSP.

  9. Atomic Energy Act (AtG) and subordinate legislation. 19. ed.

    International Nuclear Information System (INIS)

    Ziegler, E.

    1995-01-01

    This 19th edition covers the amendments added since the 17th edition ( March 1994 ) referring to the following: (1) AtG sections 7 and 9a (Artikelgesetz, as of 19.7. 1994, published in BGBl I, p. 1618 ff); (2) incorporation of the legal requirements governing the environmental impact statement (EIS) in compliance with the EIS Act (UVPG) into the Nuclear Installations Ordinance (BGBl I, p. 181 ff); (3) amendment of the Radiation Protection Ordinance (StrlSchV) in sections 6, 22, 31, 42, 87, sub-sec. 2, due to the new act on medical products, in section 41 due to the amended act on health care facilities and services, and in section 87, sub-sec. 1 due to section 7 of the 31st penal reform law - 2nd law to combat environmental crime; (4) amendment of the Preventive Radiation Protection Act in section 11, extension of competence of the BfS (Federal Rad. Prot. Office); (5) amendment of the Penal Code, environmental crime committed by release of ionizing radiation, or faulty construction of a nuclear installation; (6) update of provisions concerning competences of the federal states in implementation of nuclear laws. In the 19th edition of the commentary, the numbering of the various acts and ordinances, and the relevant page numbering have been completely revised. (HP) [de

  10. The observation of mitochondrial movement and ATG5 position in Arabidopsis during the process of infection with virulent and avirulent P. syringae strains

    Science.gov (United States)

    Yang, Liu; Ma, Chao; Chen, Wen li

    2012-03-01

    Infection of plants with pathogens leads to programmed cell death (PCD) associated with the pathogen-triggered hypersensitive response (HR) during plant innate immunity. In this study, the effects of infection by virulent Pseudomonas syringae pv. tomato (Pst) DC3000 and strains harboring avirulence factors AvrRps4 on the induction of HR-PCD were compared. We used Arabidopsis thaliana plants as materials, which expressed green fluorescent protein labeled mitochondria (mito-GFP) and green fluorescent protein tagged ATG5 (ATG5-GFP), these GFP are instantaneous expression. We found both Pst DC3000 and Pst-avrRps4 could induce mitochondria to assemble, the effect of Pst DC3000 was more obvious. ATG5 was located in chloroplasts after infection with Pst DC3000 or Pst-avrRps4. Under the condition of Pst-avrRps4, the expression of ATG5 was stronger than Pst DC3000 treatment.

  11. Tracking frequency laser distance gauge

    International Nuclear Information System (INIS)

    Phillips, J.D.; Reasenberg, R.D.

    2005-01-01

    Advanced astronomical missions with greatly enhanced resolution and physics missions of unprecedented accuracy will require laser distance gauges of substantially improved performance. We describe a laser gauge, based on Pound-Drever-Hall locking, in which the optical frequency is adjusted to maintain an interferometer's null condition. This technique has been demonstrated with pm performance. Automatic fringe hopping allows it to track arbitrary distance changes. The instrument is intrinsically free of the nm-scale cyclic bias present in traditional (heterodyne) high-precision laser gauges. The output is a radio frequency, readily measured to sufficient accuracy. The laser gauge has operated in a resonant cavity, which improves precision, can suppress the effects of misalignments, and makes possible precise automatic alignment. The measurement of absolute distance requires little or no additional hardware, and has also been demonstrated. The proof-of-concept version, based on a stabilized HeNe laser and operating on a 0.5 m path, has achieved 10 pm precision with 0.1 s integration time, and 0.1 mm absolute distance accuracy. This version has also followed substantial distance changes as fast as 16 mm/s. We show that, if the precision in optical frequency is a fixed fraction of the linewidth, both incremental and absolute distance precision are independent of the distance measured. We discuss systematic error sources, and present plans for a new version of the gauge based on semiconductor lasers and fiber-coupled components

  12. Small gauge vitrectomy: Recent update

    Science.gov (United States)

    Khanduja, Sumeet; Kakkar, Ashish; Majumdar, Saptrishi; Vohra, Rajpal; Garg, Satpal

    2013-01-01

    Small gauge vitrectomy, also known as minimally invasive vitreous surgery (MIVS), is a classic example of progress in biomedical engineering. Disparity in conjunctival and scleral wound location and reduction in wound diameter are its core principles. Fluidic changes include increased pressure head loss with consequent reduction in infusional flow rate and use of higher aspiration vacuum at the cutter port. Increase An increase in port open/port closed time maintains an adequate rate of vitreous removal. High Intensity Discharge (HID) lamps maintain adequate illumination in spite of a decrease in the number of fiberoptic fibers. The advantages of MIVS are, a shorter surgical time, minimal conjunctival damage, and early postoperative recovery. Most complications are centered on wound stability and risk of postoperative hypotony, endophthalmitis, and port site retinal break formation. MIVS is suited in most cases, however, it can cause dehiscence of recent cataract wounds. Retraction of the infusion cannula in the suprachoroidal space may occur in eyes with scleral thinning. As a lot has been published and discussed about sutureless vitrectomy a review of this subject is necessary. A PubMed search was performed in December 2011 with terms small gauge vitrectomy, 23-gauge vitrectomy, 25-gauge vitrectomy, and 27 gauge vitrectomy, which were revised in August 2012. There were no restrictions on the date of publication but it was restricted to articles in English or other languages, if there abstracts were available in English. PMID:23772118

  13. Small gauge vitrectomy: Recent update

    Directory of Open Access Journals (Sweden)

    Sumeet Khanduja

    2013-01-01

    Full Text Available Small gauge vitrectomy, also known as minimally invasive vitreous surgery (MIVS, is a classic example of progress in biomedical engineering. Disparity in conjunctival and scleral wound location and reduction in wound diameter are its core principles. Fluidic changes include increased pressure head loss with consequent reduction in infusional flow rate and use of higher aspiration vacuum at the cutter port. Increase An increase in port open/port closed time maintains an adequate rate of vitreous removal. High Intensity Discharge (HID lamps maintain adequate illumination in spite of a decrease in the number of fiberoptic fibers. The advantages of MIVS are, a shorter surgical time, minimal conjunctival damage, and early postoperative recovery. Most complications are centered on wound stability and risk of postoperative hypotony, endophthalmitis, and port site retinal break formation. MIVS is suited in most cases, however, it can cause dehiscence of recent cataract wounds. Retraction of the infusion cannula in the suprachoroidal space may occur in eyes with scleral thinning. As a lot has been published and discussed about sutureless vitrectomy a review of this subject is necessary. A PubMed search was performed in December 2011 with terms small gauge vitrectomy, 23-gauge vitrectomy, 25-gauge vitrectomy, and 27 gauge vitrectomy, which were revised in August 2012. There were no restrictions on the date of publication but it was restricted to articles in English or other languages, if there abstracts were available in English.

  14. Ultrasound-guided diagnostic breast biopsy methodology: retrospective comparison of the 8-gauge vacuum-assisted biopsy approach versus the spring-loaded 14-gauge core biopsy approach

    Science.gov (United States)

    2011-01-01

    Background Ultrasound-guided diagnostic breast biopsy technology represents the current standard of care for the evaluation of indeterminate and suspicious lesions seen on diagnostic breast ultrasound. Yet, there remains much debate as to which particular method of ultrasound-guided diagnostic breast biopsy provides the most accurate and optimal diagnostic information. The aim of the current study was to compare and contrast the 8-gauge vacuum-assisted biopsy approach and the spring-loaded 14-gauge core biopsy approach. Methods A retrospective analysis was done of all ultrasound-guided diagnostic breast biopsy procedures performed by either the 8-gauge vacuum-assisted biopsy approach or the spring-loaded 14-gauge core biopsy approach by a single surgeon from July 2001 through June 2009. Results Among 1443 ultrasound-guided diagnostic breast biopsy procedures performed, 724 (50.2%) were by the 8-gauge vacuum-assisted biopsy technique and 719 (49.8%) were by the spring-loaded 14-gauge core biopsy technique. The total number of false negative cases (i.e., benign findings instead of invasive breast carcinoma) was significantly greater (P = 0.008) in the spring-loaded 14-gauge core biopsy group (8/681, 1.2%) as compared to in the 8-gauge vacuum-assisted biopsy group (0/652, 0%), with an overall false negative rate of 2.1% (8/386) for the spring-loaded 14-gauge core biopsy group as compared to 0% (0/148) for the 8-gauge vacuum-assisted biopsy group. Significantly more (P guided diagnostic breast biopsy procedure. Significantly more (P guided diagnostic breast biopsy procedure. Conclusions In appropriately selected cases, the 8-gauge vacuum-assisted biopsy approach appears to be advantageous to the spring-loaded 14-gauge core biopsy approach for providing the most accurate and optimal diagnostic information. PMID:21835024

  15. miR-34a Modulates Angiotensin II-Induced Myocardial Hypertrophy by Direct Inhibition of ATG9A Expression and Autophagic Activity

    Science.gov (United States)

    Huang, He; Ye, Jing; Pan, Wei; Zhong, Yun; Cheng, Chuanfang; You, Xiangyu; Liu, Benrong; Xiong, Longgen; Liu, Shiming

    2014-01-01

    Cardiac hypertrophy is characterized by thickening myocardium and decreasing in heart chamber volume in response to mechanical or pathological stress, but the underlying molecular mechanisms remain to be defined. This study investigated altered miRNA expression and autophagic activity in pathogenesis of cardiac hypertrophy. A rat model of myocardial hypertrophy was used and confirmed by heart morphology, induction of cardiomyocyte autophagy, altered expression of autophagy-related ATG9A, LC3 II/I and p62 proteins, and decrease in miR-34a expression. The in vitro data showed that in hypertrophic cardiomyocytes induced by Ang II, miR-34a expression was downregulated, whereas ATG9A expression was up-regulated. Moreover, miR-34a was able to bind to ATG9A 3′-UTR, but not to the mutated 3′-UTR and inhibited ATG9A protein expression and autophagic activity. The latter was evaluated by autophagy-related LC3 II/I and p62 levels, TEM, and flow cytometry in rat cardiomyocytes. In addition, ATG9A expression induced either by treatment of rat cardiomyocytes with Ang II or ATG9A cDNA transfection upregulated autophagic activity and cardiomyocyte hypertrophy in both morphology and expression of hypertrophy-related genes (i.e., ANP and β-MHC), whereas knockdown of ATG9A expression downregulated autophagic activity and cardiomyocyte hypertrophy. However, miR-34a antagonized Ang II-stimulated myocardial hypertrophy, whereas inhibition of miR-34a expression aggravated Ang II-stimulated myocardial hypertrophy (such as cardiomyocyte hypertrophy-related ANP and β-MHC expression and cardiomyocyte morphology). This study indicates that miR-34a plays a role in regulation of Ang II-induced cardiomyocyte hypertrophy by inhibition of ATG9A expression and autophagic activity. PMID:24728149

  16. MdATG18a overexpression improves tolerance to nitrogen deficiency and regulates anthocyanin accumulation through increased autophagy in transgenic apple.

    Science.gov (United States)

    Sun, Xun; Jia, Xin; Huo, Liuqing; Che, Runmin; Gong, Xiaoqing; Wang, Ping; Ma, Fengwang

    2018-02-01

    Nitrogen (N) availability is an essential factor for plant growth. Recycling and remobilization of N have strong impacts on crop yield and quality under N deficiency. Autophagy is a critical nutrient-recycling process that facilitates remobilization under starvation. We previously showed that an important AuTophaGy (ATG) protein from apple, MdATG18a, has a positive role in drought tolerance. In this study, we explored its biological role in response to low-N. Overexpression of MdATG18a in both Arabidopsis and apple improved tolerance to N-depletion and caused a greater accumulation of anthocyanin. The increased anthocyanin concentration in transgenic apple was possibly due to up-regulating flavonoid biosynthetic and regulatory genes (MdCHI, MdCHS, MdANS, MdPAL, MdUFGT, and MdMYB1) and higher soluble sugars concentration. MdATG18a overexpression enhanced starch degradation with up-regulating amylase gene (MdAM1) and up-regulated sugar metabolism related genes (MdSS1, MdHXKs, MdFK1, and MdNINVs). Furthermore, MdATG18a functioned in nitrate uptake and assimilation by up-regulating nitrate reductase MdNIA2 and 3 high-affinity nitrate transporters MdNRT2.1/2.4/2.5. MdATG18a overexpression also elevated other important MdATG genes expression and autophagosomes formation under N-depletion, which play key contributions to above changes. Together, these results demonstrate that overexpression of MdATG18a enhances tolerance to N-deficiencies and plays positive roles in anthocyanin biosynthesis through greater autophagic activity. © 2017 John Wiley & Sons Ltd.

  17. Gauge Theories of Vector Particles

    Science.gov (United States)

    Glashow, S. L.; Gell-Mann, M.

    1961-04-24

    The possibility of generalizing the Yang-Mills trick is examined. Thus we seek theories of vector bosons invariant under continuous groups of coordinate-dependent linear transformations. All such theories may be expressed as superpositions of certain "simple" theories; we show that each "simple theory is associated with a simple Lie algebra. We may introduce mass terms for the vector bosons at the price of destroying the gauge-invariance for coordinate-dependent gauge functions. The theories corresponding to three particular simple Lie algebras - those which admit precisely two commuting quantum numbers - are examined in some detail as examples. One of them might play a role in the physics of the strong interactions if there is an underlying super-symmetry, transcending charge independence, that is badly broken. The intermediate vector boson theory of weak interactions is discussed also. The so-called "schizon" model cannot be made to conform to the requirements of partial gauge-invariance.

  18. Introduzione alle teorie di gauge

    CERN Document Server

    Cabibbo, Nicola; Benhar, Omar

    2016-01-01

    "Introduzione alle Teorie di Gauge" completa la serie di tre volumi basati sulle lezioni dei corsi di Meccanica Quantistica Relativistica, Interazioni Elettrodeboli e Teorie di Gauge, impartite dagli autori agli studenti delle Lauree Magistrali in Fisica e Astronomia & Astrofisica dell'Universita "La Sapienza" di Roma, nell'arco di qualche decennio. L'obiettivo principale del volume è di introdurre i concetti di base della rinormalizzazione nella teoria quantistica dei campi e i fondamenti delle moderne teorie di Gauge. Anche se collegato ai volumi precedenti, il libro si presta ad una lettura indipendente, che presume solo conoscenze generali di relativita speciale, della seconda quantizzazione e della fenomenologia delle interazioni elettrodeboli. Lo strumento di base è l'integrale sui cammini di Feynman, introdotto nei capitoli iniziali e sistematicamente impiegato nel seguito. L'esposizione segue un percorso pedagogico, che parte dal caso semplice dell'ampiezza di transizione in meccanica quantistic...

  19. Self-modulating pressure gauge

    Science.gov (United States)

    Edwards, D. Jr.; Lanni, C.P.

    1979-08-07

    An ion gauge is disclosed having a reduced x-ray limit and means for measuring that limit. The gauge comprises an ion gauge of the Bayard-Alpert type having a short collector and having means for varying the grid-collector voltage. The x-ray limit (i.e. the collector current resulting from x-rays striking the collector) may then be determined by the formula: I/sub x/ = ..cap alpha..I/sub l/ - I/sub h//..cap alpha.. - l where: I/sub x/ = x-ray limit, I/sub l/ and I/sub h/ = the collector current at the lower and higher grid voltage respectively; and, ..cap alpha.. = the ratio of the collector current due to positive ions at the higher voltage to that at the lower voltage.

  20. Carbon nanotubes based vacuum gauge

    Science.gov (United States)

    Rudyk, N. N.; Il’in, O. I.; Il’ina, M. V.; Fedotov, A. A.; Klimin, V. S.; Ageev, O. A.

    2017-11-01

    We have created an ionization type Vacuum gauge with sensor element based on an array of vertically aligned carbon nanotubes. Obtained asymmetrical current-voltage characteristics at different voltage polarity on the electrode with the CNTs. It was found that when applying a negative potential on an electrode with the CNTs, the current in the gap is higher than at a positive potential. In the pressure range of 1 ÷ 103 Torr vacuum gauge sensitivity was 6 mV/Torr (at a current of 4.5·10-5 A) and in the range of 10-5 ÷ 1 Torr was 10 mV/Torr (at a current of 1.3·10-5 A). It is shown that the energy efficiency of vacuum gauge can be increased in the case where electrode with CNT operates as an emitter of electrons.

  1. Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54.

    Science.gov (United States)

    Maqbool, Abbas; Hughes, Richard K; Dagdas, Yasin F; Tregidgo, Nicholas; Zess, Erin; Belhaj, Khaoula; Round, Adam; Bozkurt, Tolga O; Kamoun, Sophien; Banfield, Mark J

    2016-09-16

    Filamentous plant pathogens deliver effector proteins to host cells to promote infection. The Phytophthora infestans RXLR-type effector PexRD54 binds potato ATG8 via its ATG8 family-interacting motif (AIM) and perturbs host-selective autophagy. However, the structural basis of this interaction remains unknown. Here, we define the crystal structure of PexRD54, which includes a modular architecture, including five tandem repeat domains, with the AIM sequence presented at the disordered C terminus. To determine the interface between PexRD54 and ATG8, we solved the crystal structure of potato ATG8CL in complex with a peptide comprising the effector's AIM sequence, and we established a model of the full-length PexRD54-ATG8CL complex using small angle x-ray scattering. Structure-informed deletion of the PexRD54 tandem domains reveals retention of ATG8CL binding in vitro and in planta This study offers new insights into structure/function relationships of oomycete RXLR effectors and how these proteins engage with host cell targets to promote disease. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  2. Translational initiation in Leishmania tarentolae and Phytomonas serpens (Kinetoplastida) is strongly influenced by pre-ATG triplet and its 5' sequence context.

    Science.gov (United States)

    Lukes, Julius; Paris, Zdenek; Regmi, Sandesh; Breitling, Reinhard; Mureev, Sergey; Kushnir, Susanna; Pyatkov, Konstantin; Jirků, Milan; Alexandrov, Kirill A

    2006-08-01

    To investigate the influence of sequence context of translation initiation codon on translation efficiency in Kinetoplastida, we constructed a library of expression plasmids randomized in the three nucleotides prefacing ATG of a reporter gene encoding enhanced green fluorescent protein (EGFP). All 64 possible combinations of pre-ATG triplets were individually stably integrated into the rDNA locus of Leishmania tarentolae and the resulting cell lines were assessed for EGFP expression. The expression levels were quantified directly by measuring the fluorescence of EGFP protein in living cells and confirmed by Western blotting. We observed a strong influence of the pre-ATG triplet on the level of protein expression over a 20-fold range. To understand the degree of evolutionary conservation of the observed effect, we transformed Phytomonas serpens, a trypanosomatid parasite of plants, with a subset of the constructs. The pattern of translational efficiency mediated by individual pre-ATG triplets in this species was similar to that observed in L. tarentolae. However, the pattern of translational efficiency of two other proteins (red fluorescent protein and tetracycline repressor) containing selected pre-ATG triplets did not correlate with either EGFP or each other. Thus, we conclude that a conserved mechanism of translation initiation site selection exists in kinetoplastids that is strongly influenced not only by the pre-ATG sequences but also by the coding region of the gene.

  3. Translational groups as generators of gauge transformations

    International Nuclear Information System (INIS)

    Scaria, Tomy

    2003-01-01

    We examine the gauge generating nature of the translational subgroup of Wigner's little group for the case of massless tensor gauge theories and show that the gauge transformations generated by the translational group are only a subset of the complete set of gauge transformations. We also show that, just as in the case of topologically massive gauge theories, translational groups act as generators of gauge transformations in gauge theories obtained by extending massive gauge noninvariant theories by a Stueckelberg mechanism. The representations of the translational groups that generate gauge transformations in such Stueckelberg extended theories can be obtained by the method of dimensional descent. We illustrate these results with the examples of Stueckelberg extended first class versions of Proca, Einstein-Pauli-Fierz, and massive Kalb-Ramond theories in 3+1 dimensions. A detailed analysis of the partial gauge generation in massive and massless second rank symmetric gauge theories is provided. The gauge transformations generated by the translational group in two-form gauge theories are shown to explicitly manifest the reducibility of gauge transformations in these theories

  4. The Problem Of Gauge Theory

    CERN Document Server

    Witten, Edward

    2008-01-01

    I sketch what it is supposed to mean to quantize gauge theory, and how this can be made more concrete in perturbation theory and also by starting with a finite-dimensional lattice approximation. Based on real experiments and computer simulations, quantum gauge theory in four dimensions is believed to have a mass gap. This is one of the most fundamental facts that makes the Universe the way it is. This article is the written form of a lecture presented at the conference "Geometric Analysis: Past and Future" (Harvard University, August 27-September 1, 2008), in honor of the 60th birthday of S.-T. Yau.

  5. Renormalization of gauge fields models

    International Nuclear Information System (INIS)

    Becchi, C.; Rouet, A.; Stora, R.

    1974-01-01

    A new approach to gauge field models is described. It is based on the Bogoliubov-Parasiuk-Hepp-Zimmermann (BPHZ) renormalization scheme making extensive use of the quantum action principle, and the Slavnov invariance. The quantum action principle being first summarized in the framework of the BPHZ is then applied to a global symmetry problem. The symmetry property of the gauge field Lagrangians in the tree approximation is exhibited, and the preservation of this property at the quantum level is discussed. The main results relative to the Abelian and SU(2) Higgs-Kibble models are briefly reviewed [fr

  6. Dark coupling and gauge invariance

    International Nuclear Information System (INIS)

    Gavela, M.B.; Honorez, L. Lopez; Mena, O.; Rigolin, S.

    2010-01-01

    We study a coupled dark energy-dark matter model in which the energy-momentum exchange is proportional to the Hubble expansion rate. The inclusion of its perturbation is required by gauge invariance. We derive the linear perturbation equations for the gauge invariant energy density contrast and velocity of the coupled fluids, and we determine the initial conditions. The latter turn out to be adiabatic for dark energy, when assuming adiabatic initial conditions for all the standard fluids. We perform a full Monte Carlo Markov Chain likelihood analysis of the model, using WMAP 7-year data

  7. An introduction to gauge theories

    CERN Document Server

    Cabibbo, Nicola; Benhar, Omar

    2017-01-01

    Written by three of the world's leading experts on particle physics and the standard model, including an award-winning former director general of CERN, this book provides a completely up-to-date account of gauge theories. Starting from Feynman’s path integrals, Feynman rules are derived, gauge fixing and Faddeev-Popov ghosts are discussed, and renormalization group equations are derived. Several important applications to quantum electrodynamics and quantum chromodynamics (QCD) are discussed, including the one-loop derivation of asymptotic freedom for QCD.

  8. Gauge theories, tessellations & Riemann surfaces

    International Nuclear Information System (INIS)

    He, Yang-Hui; Loon, Mark van

    2014-01-01

    We study and classify regular and semi-regular tessellations of Riemann surfaces of various genera and investigate their corresponding supersymmetric gauge theories. These tessellations are generalizations of brane tilings, or bipartite graphs on the torus as well as the Platonic and Archimedean solids on the sphere. On higher genus they give rise to intricate patterns. Special attention will be paid to the master space and the moduli space of vacua of the gauge theory and to how their geometry is determined by the tessellations.

  9. Low Scale Flavor Gauge Symmetries

    CERN Document Server

    Grinstein, Benjamín; Villadoro, Giovanni

    2010-01-01

    We study the possibility of gauging the Standard Model flavor group. Anomaly cancellation leads to the addition of fermions whose mass is inversely proportional to the known fermion masses. In this case all flavor violating effects turn out to be controlled roughly by the Standard Model Yukawa, suppressing transitions for the light generations. Due to the inverted hierarchy the scale of new gauge flavor bosons could be as low as the electroweak scale without violating any existing bound but accessible at the Tevatron and the LHC. The mechanism of flavor protection potentially provides an alternative to Minimal Flavor Violation, with flavor violating effects suppressed by hierarchy of scales rather than couplings.

  10. Gauged baryon and lepton numbers

    International Nuclear Information System (INIS)

    Foot, R.; Joshi, G.C.; Lew, H.

    1989-01-01

    A possible extension of the Standard Model can be defined by gauging the global baryon and lepton number U(1) symmetries. Gauging baryon and lepton numbers provide a natural framework for the see-saw mechanism in the lepton sector, and the Peccei-Quinn mechanism in the quark sector. Another consequence of this extension is that the usual three generations of fermions are not anomaly free. However the authors consider a wider framework involving the existence of generations with exotic SU(2) L tensor product U(1) Y quantum numbers. This allows them to derive a minimal spectrum of fermions which contain the known quarks and leptons. 12 refs

  11. Stream Gauges and Satellite Measurements

    Science.gov (United States)

    Alsdorf, D. E.

    2010-12-01

    Satellite measurements should not be viewed as a replacement for stream gauges. However, occasionally it is suggested that because satellite-based measurements can provide river discharge, a motivation for satellite approaches is an increasing lack of stream gauges. This is an argument for more stream gauges, but not necessarily for satellite measurements. Rather, in-situ and spaceborne methods of estimating discharge are complementary. Stream gauges provide frequent measurements at one point in the river reach whereas satellites have the potential to measure throughout all reaches but at orbital repeat intervals of days to weeks. The Surface Water and Ocean Topography satellite mission (SWOT) is an opportunity to further develop these complements. The motivation for SWOT, and indeed for any satellite based method of estimating discharge, should not be as a replacement for stream gauges. Scientific and application uses should motivate the measurements. For example, understanding floods with their dynamic water surfaces are best sampled from remote platforms that provide water surface elevations throughout the floodwave. As another example, today’s water and energy balance models are giving outputs at increasing spatial resolution and are making use of water surface elevations throughout the modeled basin. These models require a similar resolution in the calibrating and validating observations. We should also be aware of practical limitations. In addition to providing spatially distributed hydrodynamic measurements on rivers, SWOT will be able to measure storage changes in the estimated 30 million lakes in the world that are larger than a hectare. Knowing the storage changes in these lakes is especially important in certain regions such as the Arctic but gauging even a small fraction of these is impractical. Another motivator for satellite methods is that even in the presence of stream gauges, discharge data is not always well shared throughout all countries

  12. Machines for lattice gauge theory

    International Nuclear Information System (INIS)

    Mackenzie, P.B.

    1989-05-01

    The most promising approach to the solution of the theory of strong interactions is large scale numerical simulation using the techniques of lattice gauge theory. At the present time, computing requirements for convincing calculations of the properties of hadrons exceed the capabilities of even the most powerful commercial supercomputers. This has led to the development of massively parallel computers dedicated to lattice gauge theory. This talk will discuss the computing requirements behind these machines, and general features of the components and architectures of the half dozen major projects now in existence. 20 refs., 1 fig

  13. Gauge theory and variational principles

    CERN Document Server

    Bleecker, David

    2005-01-01

    This text provides a framework for describing and organizing the basic forces of nature and the interactions of subatomic particles. A detailed and self-contained mathematical account of gauge theory, it is geared toward beginning graduate students and advanced undergraduates in mathematics and physics. This well-organized treatment supplements its rigor with intuitive ideas.Starting with an examination of principal fiber bundles and connections, the text explores curvature; particle fields, Lagrangians, and gauge invariance; Lagrange's equation for particle fields; and the inhomogeneous field

  14. Gyrocenter-gauge kinetic theory

    International Nuclear Information System (INIS)

    Qin, H.; Tang, W.M.; Lee, W.W.

    2000-01-01

    Gyrocenter-gauge kinetic theory is developed as an extension of the existing gyrokinetic theories. In essence, the formalism introduced here is a kinetic description of magnetized plasmas in the gyrocenter coordinates which is fully equivalent to the Vlasov-Maxwell system in the particle coordinates. In particular, provided the gyroradius is smaller than the scale-length of the magnetic field, it can treat high frequency range as well as the usual low frequency range normally associated with gyrokinetic approaches. A significant advantage of this formalism is that it enables the direct particle-in-cell simulations of compressional Alfven waves for MHD applications and of RF waves relevant to plasma heating in space and laboratory plasmas. The gyrocenter-gauge kinetic susceptibility for arbitrary wavelength and arbitrary frequency electromagnetic perturbations in a homogeneous magnetized plasma is shown to recover exactly the classical result obtained by integrating the Vlasov-Maxwell system in the particle coordinates. This demonstrates that all the waves supported by the Vlasov-Maxwell system can be studied using the gyrocenter-gauge kinetic model in the gyrocenter coordinates. This theoretical approach is so named to distinguish it from the existing gyrokinetic theory, which has been successfully developed and applied to many important low-frequency and long parallel wavelength problems, where the conventional meaning of gyrokinetic has been standardized. Besides the usual gyrokinetic distribution function, the gyrocenter-gauge kinetic theory emphasizes as well the gyrocenter-gauge distribution function, which sometimes contains all the physics of the problems being studied, and whose importance has not been realized previously. The gyrocenter-gauge distribution function enters Maxwell's equations through the pull-back transformation of the gyrocenter transformation, which depends on the perturbed fields. The efficacy of the gyrocenter-gauge kinetic approach is

  15. The Origins of Lattice Gauge Theory

    International Nuclear Information System (INIS)

    Wilson, Kenneth

    2004-01-01

    The main focus of this talk is an anecdotal account of the history underlying my 1974 article entitled 'Confinement of Quarks.' In preparing this talk, I will draw on a historical interview conducted by the project for History of Recent Science and Technology at the Dibner Institute for the History of Science and Technology at MIT, and on a theory of invention proposed by Peter Drucker in his book 'Innovation and Entrepreneurship.' I will explain this theory; no background is needed. The account will start with related work in the 1960's. I will end the talk with a plea for lattice gauge researchers to be alert for unexpected scalar or vector colored particles that are invisible to experimentalists yet could start to spoil the agreement of computations with experiment. Note: In association with the Symposium ' 'Lattice 2004,' June 21 to June 26, 2004.

  16. Some observations on interpolating gauges and non-covariant gauges

    Indian Academy of Sciences (India)

    tion that are not normally taken into account in the BRST formalism that ignores the ε-term, and that they are characteristic of the way the singularities in propagators are handled. We argue that a prescription, in general, will require renormalization; if at all it is to be viable. Keywords. Non-covariant gauges; interpolating ...

  17. Quantum gauge freedom in very special relativity

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyay, Sudhaker, E-mail: sudhakerupadhyay@gmail.com [Centre for Theoretical Studies, Indian Institute of Technology Kharagpur, Kharagpur-721302, West Bengal (India); Panigrahi, Prasanta K., E-mail: pprasanta@iiserkol.ac.in [Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, West Bengal (India)

    2017-02-15

    We demonstrate Yokoyama gaugeon formalism for the Abelian one-form gauge (Maxwell) as well as for Abelian two-form gauge theory in the very special relativity (VSR) framework. In VSR scenario, the extended action due to introduction of gaugeon fields also possesses form invariance under quantum gauge transformations. It is observed that the gaugeon field together with gauge field naturally acquire mass, which is different from the conventional Higgs mechanism. The quantum gauge transformation implements a shift in gauge parameter. Further, we analyze the BRST symmetric gaugeon formalism in VSR which embeds only one subsidiary condition rather than two.

  18. False vacuum decay in gauge theory

    Science.gov (United States)

    Endo, Motoi; Moroi, Takeo; Nojiri, Mihoko M.; Shoji, Yutaro

    2017-11-01

    The decay rate of a false vacuum is studied in gauge theory, paying particular attention to its gauge invariance. Although the decay rate should not depend on the gauge parameter ξ according to the Nielsen identity, the gauge invariance of the result of a perturbative calculation has not been clearly shown. We give a prescription to perform a one-loop calculation of the decay rate, with which a manifestly gauge-invariant expression of the decay rate is obtained. We also discuss the renormalization necessary to make the result finite, and show that the decay rate is independent of the gauge parameter even after the renormalization.

  19. Basal Autophagy Is Altered in Lagotto Romagnolo Dogs with an ATG4D Mutation.

    Science.gov (United States)

    Syrjä, Pernilla; Anwar, Tahira; Jokinen, Tarja; Kyöstilä, Kaisa; Jäderlund, Karin Hultin; Cozzi, Francesca; Rohdin, Cecilia; Hahn, Kerstin; Wohlsein, Peter; Baumgärtner, Wolfgang; Henke, Diana; Oevermann, Anna; Sukura, Antti; Leeb, Tosso; Lohi, Hannes; Eskelinen, Eeva-Liisa

    2017-11-01

    A missense variant in the autophagy-related ATG4D-gene has been associated with a progressive degenerative neurological disease in Lagotto Romagnolo (LR) dogs. In addition to neural lesions, affected dogs show an extraneural histopathological phenotype characterized by severe cytoplasmic vacuolization, a finding not previously linked with disturbed autophagy in animals. Here we aimed at testing the hypothesis that autophagy is altered in the affected dogs, at reporting the histopathology of extraneural tissues and at excluding lysosomal storage diseases. Basal and starvation-induced autophagy were monitored by Western blotting and immunofluorescence of microtubule associated protein 1A/B light chain3 (LC3) in fibroblasts from 2 affected dogs. The extraneural findings of 9 euthanized LRs and skin biopsies from 4 living affected LRs were examined by light microscopy, electron microscopy, and immunohistochemistry (IHC), using antibodies against autophagosomal membranes (LC3), autophagic cargo (p62), and lysosomal membranes (LAMP2). Biochemical screening of urine and fibroblasts of 2 affected dogs was performed. Under basal conditions, the affected fibroblasts contained significantly more LC3-II and LC3-positive vesicles than did the controls. Morphologically, several cells, including serous secretory epithelium, endothelial cells, pericytes, plasma cells, and macrophages, contained cytoplasmic vacuoles with an ultrastructure resembling enlarged amphisomes, endosomes, or multivesicular bodies. IHC showed strong membranous LAMP2 positivity only in sweat glands. The results show that basal but not induced autophagy is altered in affected fibroblasts. The ultrastructure of affected cells is compatible with altered autophagic and endo-lysosomal vesicular traffic. The findings in this spontaneous disease provide insight into possible tissue-specific roles of basal autophagy.

  20. Gauge unification of fundamental forces

    International Nuclear Information System (INIS)

    Salam, A.

    1980-02-01

    After having reviewed briefly the last twenty years' progress in the theory of unification, with the twin aspects of development of a gauge theory of basic interactions linked with internal symmetry and the spontaneous breaking of these symmetries, the Nobel prize winners have summarized the present situation and the immediate problems. At the end, an extrapolation of the future is also given

  1. Supersymmetric gauge invariant interaction revisited

    International Nuclear Information System (INIS)

    Smith, A.W.; Pontificia Univ. Catolica do Rio de Janeiro; Barcelos Neto, J.

    1983-01-01

    A supersymmetric Lagrangian invariant under local U(1) gauge transformations is written in terms of a non-chiral superfield which substitute the usual vector supermultiplet together with chiral and anti-chiral superfields. The Euler equations allow us to obtain the off-shell version of the usual Lagrangian for supersymmetric quantum-electrodynamics (SQED). (Author) [pt

  2. Singlets of fermionic gauge symmetries

    NARCIS (Netherlands)

    Bergshoeff, E.A.; Kallosh, R.E.; Rahmanov, M.A.

    1989-01-01

    We investigate under which conditions singlets of fermionic gauge symmetries which are "square roots of gravity" can exist. Their existence is non-trivial because there are no fields neutral in gravity. We tabulate several examples of singlets of global and local supersymmetry and κ-symmetry and

  3. Gauge symmetries, topology, and quantisation

    International Nuclear Information System (INIS)

    Balachandran, A.P.

    1994-01-01

    The following two loosely connected sets of topics are reviewed in these lecture notes: (1) Gauge invariance, its treatment in field theories and its implications for internal symmetries and edge states such as those in the quantum Hall effect. (2) Quantisation on multiply connected spaces and a topological proof the spin-statistics theorem which avoids quantum field theory and relativity. Under (1), after explaining the meaning of gauge invariance and the theory of constraints, we discuss boundary conditions on gauge transformations and the definition of internal symmetries in gauge field theories. We then show how the edge states in the quantum Hall effect can be derived from the Chern-Simons action using the preceding ideas. Under (2), after explaining the significance of fibre bundles for quantum physics, we review quantisation on multiply connected spaces in detail, explaining also mathematical ideas such as those of the universal covering space and the fundamental group. These ideas are then used to prove the aforementioned topological spin-statistics theorem

  4. A New Gauge Mediation Theory

    CERN Document Server

    Antoniadis, Ignatios; Delgado, A; Quirós, Mariano

    2006-01-01

    We propose a class of models with gauge mediation of supersymmetry breaking, inspired by simple brane constructions, where R-symmetry is very weakly broken. The gauge sector has an extended N=2 supersymmetry and the two electroweak Higgses form an N=2 hypermultiplet, while quarks and leptons remain in N=1 chiral multiplets. Supersymmetry is broken via the D-term expectation value of a secluded U(1) and it is transmitted to the Standard Model via gauge interactions of messengers in N=2 hypermultiplets: gauginos thus receive Dirac masses. The model has several distinct experimental signatures with respect to ordinary models of gauge or gravity mediation realizations of the Minimal Supersymmetric Standard Model (MSSM). First, it predicts extra states as a third chargino that can be observed at collider experiments. Second, the absence of a D-flat direction in the Higgs sector implies a lightest Higgs behaving exactly as the Standard Model one and thus a reduction of the `little' fine-tuning in the low tan(beta) ...

  5. Spacetime Metrics from Gauge Potentials

    Directory of Open Access Journals (Sweden)

    Ettore Minguzzi

    2014-03-01

    Full Text Available I present an approach to gravity in which the spacetime metric is constructed from a non-Abelian gauge potential with values in the Lie algebra of the group U(2 (or the Lie algebra of quaternions. If the curvature of this potential vanishes, the metric reduces to a canonical curved background form reminiscent of the Friedmann S3 cosmological metric.

  6. Lattice gauge theory: Present status

    International Nuclear Information System (INIS)

    Creutz, M.

    1993-09-01

    Lattice gauge theory is our primary tool for the study of non- perturbative phenomena in hadronic physics. In addition to giving quantitative information on confinement, the approach is yielding first principles calculations of hadronic spectra and matrix elements. After years of confusion, there has been significant recent progress in understanding issues of chiral symmetry on the lattice

  7. On magnetohydrodynamic gauge field theory

    Science.gov (United States)

    Webb, G. M.; Anco, S. C.

    2017-06-01

    Clebsch potential gauge field theory for magnetohydrodynamics is developed based in part on the theory of Calkin (1963 Can. J. Phys. 41 2241-51). It is shown how the polarization vector {P} in Calkin’s approach naturally arises from the Lagrange multiplier constraint equation for Faraday’s equation for the magnetic induction {B} , or alternatively from the magnetic vector potential form of Faraday’s equation. Gauss’s equation, (divergence of {B} is zero) is incorporated in the variational principle by means of a Lagrange multiplier constraint. Noether’s theorem coupled with the gauge symmetries is used to derive the conservation laws for (a) magnetic helicity, (b) cross helicity, (c) fluid helicity for non-magnetized fluids, and (d) a class of conservation laws associated with curl and divergence equations which applies to Faraday’s equation and Gauss’s equation. The magnetic helicity conservation law is due to a gauge symmetry in MHD and not due to a fluid relabelling symmetry. The analysis is carried out for the general case of a non-barotropic gas in which the gas pressure and internal energy density depend on both the entropy S and the gas density ρ. The cross helicity and fluid helicity conservation laws in the non-barotropic case are nonlocal conservation laws that reduce to local conservation laws for the case of a barotropic gas. The connections between gauge symmetries, Clebsch potentials and Casimirs are developed. It is shown that the gauge symmetry functionals in the work of Henyey (1982 Phys. Rev. A 26 480-3) satisfy the Casimir determining equations.

  8. Notes on gauge theory and gravitation

    International Nuclear Information System (INIS)

    Wallner, R.P.

    1981-01-01

    In order to investigate whether Einstein's general relativity theory (GRT) fits into the general scheme of a gauge theory, first the concept of a (classical) gauge theory is outlined in an introductionary spacetime approach. Having thus fixed the notation and the main properties of gauge fields, GRT is examined to find out what the gauge potentials and the corresponding gauge group might be. In this way the possibility of interpreting GRT as a gauge theory of the 4-dimensional translation group T(4) = (R 4 , +), and where the gauge potentials are incorporated in a T(4)-invariant way via orthonormal anholonomic basis 1-forms is considered. To include also the spin aspect a natural extension of GRT is given by gauging also the Lorentz group, whereby a Riemann-Cartan spacetime (U 4 -spacetime) comes into play. (Auth.)

  9. NAMMA SENEGAL RAIN GAUGE NETWORK V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The NAMMA Senegal Rain Gauge Network consisted of 40 rain gauge sites (AMMA 1-40) located in various places throughout Senegal, West Africa. These data files were...

  10. Remarks on gauge variables and singular Lagrangians

    International Nuclear Information System (INIS)

    Chela-Flores, J.; Janica-de-la-Torre, R.; Kalnay, A.J.; Rodriguez-Gomez, J.; Rodriguez-Nunez, J.; Tascon, R.

    1977-01-01

    The relevance is discussed of gauge theory, based on a singular Lagrangian density, to the foundations of field theory. The idea that gauge transformations could change the physics of systems where the Lagrangian is singular is examined. (author)

  11. Calibration of pressure gauge for Cherenkov detector

    CERN Document Server

    Saponjic, Nevena

    2013-01-01

    Solartron/Hamilton pressure gauges are used to monitor the gas pressure in the particle beam detectors installed in the experimental areas. Here is description of the test bench for the calibration of these gauges in Labview.

  12. Multi-step contrast sensitivity gauge

    Science.gov (United States)

    Quintana, Enrico C; Thompson, Kyle R; Moore, David G; Heister, Jack D; Poland, Richard W; Ellegood, John P; Hodges, George K; Prindville, James E

    2014-10-14

    An X-ray contrast sensitivity gauge is described herein. The contrast sensitivity gauge comprises a plurality of steps of varying thicknesses. Each step in the gauge includes a plurality of recesses of differing depths, wherein the depths are a function of the thickness of their respective step. An X-ray image of the gauge is analyzed to determine a contrast-to-noise ratio of a detector employed to generate the image.

  13. Dimensional Reduction of Nonlinear Gauge Theories

    Science.gov (United States)

    Ikeda, Noriaki; Izawa, K.-I.

    2004-09-01

    We extend 2D nonlinear gauge theory from the Poisson sigma model based on Lie algebroid to a model with additional two-form gauge fields. Dimensional reduction of 3D nonlinear gauge theory yields an example of such a model, which provides a realization of Courant algebroid by 2D nonlinear gauge theory. We see that the reduction of the base structure generically results in a modification of the target (algebroid) structure.

  14. Parameter space of general gauge mediation

    International Nuclear Information System (INIS)

    Rajaraman, Arvind; Shirman, Yuri; Smidt, Joseph; Yu, Felix

    2009-01-01

    We study a subspace of General Gauge Mediation (GGM) models which generalize models of gauge mediation. We find superpartner spectra that are markedly different from those of typical gauge and gaugino mediation scenarios. While typical gauge mediation predictions of either a neutralino or stau next-to-lightest supersymmetric particle (NLSP) are easily reproducible with the GGM parameters, chargino and sneutrino NLSPs are generic for many reasonable choices of GGM parameters.

  15. Gaugings at angles from orientifold reductions

    International Nuclear Information System (INIS)

    Roest, Diederik

    2009-01-01

    We consider orientifold reductions to N= 4 gauged supergravity in four dimensions. A special feature of this theory is that different factors of the gauge group can have relative angles with respect to the electro-magnetic SL(2) symmetry. These are crucial for moduli stabilization and de Sitter vacua. We show how such gaugings at angles generically arise in orientifold reductions.

  16. A gauge principle yielding consistent chiral theories

    International Nuclear Information System (INIS)

    Thompson, G.; Zhang, R.

    1987-02-01

    We propose a new principle in gauge theories: namely that in a given action, fields should be replaced by gauge invariant equivalents. Using this principle we study anomalous gauge theories and find that the resulting models are anomaly free, unitary and power counting renormalizable. (author). 8 refs

  17. 27 CFR 19.768 - Gauge record.

    Science.gov (United States)

    2010-04-01

    ... calendar or fiscal year; (b) Reason for making the gauge: (1) Production gauge and entry for deposit in the storage or processing account at the plant where produced; (2) Packaging of spirits or wine filled from a... gauge details, proof, and wine gallons; (2) Cooperage identification (“C” for charred, “REC” for...

  18. 27 CFR 19.483 - Recording gauge.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Recording gauge. 19.483... gauge. (a) When packages of spirits are received from customs custody in the storage account, the proprietor shall use the last official gauge to compute and record on the deposit records prescribed in § 19...

  19. 77 FR 31894 - Portable Gauge Licenses

    Science.gov (United States)

    2012-05-30

    ... COMMISSION Portable Gauge Licenses AGENCY: Nuclear Regulatory Commission. ACTION: Draft NUREG; request for... guidance for portable gauge licensees. The NRC is requesting public comment on NUREG-1556, Volume 1... Gauge Licenses.'' The document has been updated to include safety culture, security of radioactive...

  20. The gauge technique in supersymmetric QED2

    NARCIS (Netherlands)

    Roo, M. de; Steringa, J.J.

    1988-01-01

    We construct an extension of the gauge technique to two-dimensional supersymmetric gauge theories. This involves a derivation of the spectral representation of a scalar superpropagator in two dimensions. We apply the method to the massive supersymmetric Schwinger model. In the case that the gauge

  1. Wireless Ways: Business and Personal Applications of Wireless Technology.

    Science.gov (United States)

    Chung, Joe

    2001-01-01

    Describes the Art Technology Group (ATG), an electronic business and customer management company, and the work they have done with wireless technology. Highlights include designing virtual offices and supporting the resulting virtual community; the mobility it allows; problems with bandwidth; and display issues. (LRW)

  2. Gauge theory of glass transition

    International Nuclear Information System (INIS)

    Vasin, Mikhail

    2011-01-01

    A new analytical approach for the description of the glass transition in a frustrated system is suggested. The theory is based on the non-equilibrium dynamics technique, and takes into account the interaction of the local order field with the massive gauge field, which describes frustration-induced plastic deformation. The glass transition is regarded as a phase transition interrupted because of the premature critical slowing-down of one of the degrees of freedom caused by the frustrations. It is shown that freezing of the system appears when the correlation length and relaxation time of the gauge field diverge. The Vogel–Fulcher–Tammann relation for the transition kinetics and the critical exponent for the nonlinear susceptibility, 2.5∼ t correlation function dependence on time, and explains the boson peak appearance on this curve. In addition, the function of the glass transition temperature value with cooling rate is derived; this dependence fully conforms with known experimental data

  3. Towards a Neuronal Gauge Theory

    Science.gov (United States)

    Sengupta, Biswa; Tozzi, Arturo; Cooray, Gerald K.; Douglas, Pamela K.; Friston, Karl J.

    2016-01-01

    Given the amount of knowledge and data accruing in the neurosciences, is it time to formulate a general principle for neuronal dynamics that holds at evolutionary, developmental, and perceptual timescales? In this paper, we propose that the brain (and other self-organised biological systems) can be characterised via the mathematical apparatus of a gauge theory. The picture that emerges from this approach suggests that any biological system (from a neuron to an organism) can be cast as resolving uncertainty about its external milieu, either by changing its internal states or its relationship to the environment. Using formal arguments, we show that a gauge theory for neuronal dynamics—based on approximate Bayesian inference—has the potential to shed new light on phenomena that have thus far eluded a formal description, such as attention and the link between action and perception. PMID:26953636

  4. Weak interactions and gauge theories

    International Nuclear Information System (INIS)

    Gaillard, M.K.

    1979-12-01

    The status of the electroweak gauge theory, also known as quantum asthenodynamics (QAD), is examined. The major result is that the standard WS-GIM model describes the data well, although one should still look for signs of further complexity and better tests of its gauge theory aspect. A second important result is that the measured values of the three basic coupling constants of present-energy physics, g/sub s/, g, and √(5/3)g' of SU(3)/sub c/ x SU(2) 2 x U(1), are compatible with the idea that these interactions are unified at high energies. Much of the paper deals with open questions, and it takes up the following topics: the status of QAD, the scalar meson spectrum, the fermion spectrum, CP violation, and decay dynamics. 118 references, 20 figures

  5. Gauge invariant fractional electromagnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Lazo, Matheus Jatkoske, E-mail: matheuslazo@furg.br [Instituto de Matematica, Estatistica e Fisica - FURG, Rio Grande, RS (Brazil)

    2011-09-26

    Fractional derivatives and integrations of non-integers orders was introduced more than three centuries ago but only recently gained more attention due to its application on nonlocal phenomenas. In this context, several formulations of fractional electromagnetic fields was proposed, but all these theories suffer from the absence of an effective fractional vector calculus, and in general are non-causal or spatially asymmetric. In order to deal with these difficulties, we propose a spatially symmetric and causal gauge invariant fractional electromagnetic field from a Lagrangian formulation. From our fractional Maxwell's fields arose a definition for the fractional gradient, divergent and curl operators. -- Highlights: → We propose a fractional Lagrangian formulation for fractional Maxwell's fields. → We obtain gauge invariant fractional electromagnetic fields. → Our generalized fractional Maxwell's field is spatially symmetrical. → We discuss the non-causality of the theory.

  6. Gauge mediated mini-split

    Science.gov (United States)

    Cohen, Timothy; Craig, Nathaniel; Knapen, Simon

    2016-03-01

    We propose a simple model of split supersymmetry from gauge mediation. This model features gauginos that are parametrically a loop factor lighter than scalars, accommodates a Higgs boson mass of 125 GeV, and incorporates a simple solution to the μ- b μ problem. The gaugino mass suppression can be understood as resulting from collective symmetry breaking. Imposing collider bounds on μ and requiring viable electroweak symmetry breaking implies small a-terms and small tan β — the stop mass ranges from 105 to 108 GeV. In contrast with models with anomaly + gravity mediation (which also predict a one-loop loop suppression for gaugino masses), our gauge mediated scenario predicts aligned squark masses and a gravitino LSP. Gluinos, electroweakinos and Higgsinos can be accessible at the LHC and/or future colliders for a wide region of the allowed parameter space.

  7. Scattering amplitudes in gauge theories

    CERN Document Server

    Henn, Johannes M

    2014-01-01

    At the fundamental level, the interactions of elementary particles are described by quantum gauge field theory. The quantitative implications of these interactions are captured by scattering amplitudes, traditionally computed using Feynman diagrams. In the past decade tremendous progress has been made in our understanding of and computational abilities with regard to scattering amplitudes in gauge theories, going beyond the traditional textbook approach. These advances build upon on-shell methods that focus on the analytic structure of the amplitudes, as well as on their recently discovered hidden symmetries. In fact, when expressed in suitable variables the amplitudes are much simpler than anticipated and hidden patterns emerge.   These modern methods are of increasing importance in phenomenological applications arising from the need for high-precision predictions for the experiments carried out at the Large Hadron Collider, as well as in foundational mathematical physics studies on the S-matrix in quantum ...

  8. Gauge mediated mini-split

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Timothy [Institute of Theoretical Science, University of Oregon,Eugene, OR 97403 (United States); Craig, Nathaniel [Department of Physics, University of California,Santa Barbara, CA 93106 (United States); Knapen, Simon [Berkeley Center for Theoretical Physics,University of California, Berkeley, CA 94720 (United States); Theoretical Physics Group,Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)

    2016-03-15

    We propose a simple model of split supersymmetry from gauge mediation. This model features gauginos that are parametrically a loop factor lighter than scalars, accommodates a Higgs boson mass of 125 GeV, and incorporates a simple solution to the μ−b{sub μ} problem. The gaugino mass suppression can be understood as resulting from collective symmetry breaking. Imposing collider bounds on μ and requiring viable electroweak symmetry breaking implies small a-terms and small tan β — the stop mass ranges from 10{sup 5} to 10{sup 8} GeV. In contrast with models with anomaly + gravity mediation (which also predict a one-loop loop suppression for gaugino masses), our gauge mediated scenario predicts aligned squark masses and a gravitino LSP. Gluinos, electroweakinos and Higgsinos can be accessible at the LHC and/or future colliders for a wide region of the allowed parameter space.

  9. Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity

    Science.gov (United States)

    Ishibashi, Koutaro; Uemura, Takefumi; Waguri, Satoshi; Fukuda, Mitsunori

    2012-01-01

    Autophagy is a bulk degradation system in all eukaryotic cells and regulates a variety of biological activities in higher eukaryotes. Recently involvement of autophagy in the regulation of the secretory pathway has also been reported, but the molecular mechanism linking autophagy with the secretory pathway remains largely unknown. Here we show that Atg16L1, an essential protein for canonical autophagy, is localized on hormone-containing dense-core vesicles in neuroendocrine PC12 cells and that knockdown of Atg16L1 causes a dramatic reduction in the level of hormone secretion independently of autophagic activity. We also find that Atg16L1 interacts with the small GTPase Rab33A and that this interaction is required for the dense-core vesicle localization of Atg16L1 in PC12 cells. Our findings indicate that Atg16L1 regulates not only autophagy in all cell types, but also secretion from dense-core vesicles, presumably by acting as a Rab33A effector, in particular cell types. PMID:22740627

  10. Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulate unfolded protein response (UPR) that is independent on autophagy in Candida albicans.

    Science.gov (United States)

    Li, Jianrong; Yu, Qilin; Zhang, Bing; Xiao, Chenpeng; Ma, Tianyu; Yi, Xiao; Liang, Chao; Li, Mingchun

    2018-03-06

    Cellular stresses could activate several response processes, such as the unfolded protein response (UPR), autophagy and oxidative stress response to restore cellular homeostasis or render cell death. Herein, we identified the Candida albicans stress-associated endoplasmic reticulum protein 1 (SERP1), also known as Ysy6, which was involved in endoplasmic reticulum (ER) stress response. We found that deletion of both SERP1/YSY6 and ATG8 led to hypersensitivity to tunicamycin (TN), and resulted in severe mitochondrial dysfunction under this stress. UPR reporting systems illustrated that the double mutation attenuated splicing of HAC1 mRNA, followed by decreased level of UPR activation. In addition, the atg8Δ/Δ ysy6Δ/Δ double mutant had normal autophagic degradation of the ER component Sec63 under ER stress, suggesting that SERP1/Ysy6 and Atg8 synergistically regulated UPR that is independent on autophagy. We also found that deletion of both SERP1/YSY6 and ATG8 caused the loss of virulence. This study reveals the important role of SERP1/Ysy6 and Atg8 in ER stress response and virulence in C. albicans. Copyright © 2018. Published by Elsevier GmbH.

  11. Gauge invariance and Nielsen identities

    International Nuclear Information System (INIS)

    Lima, A.F. de; Bazaia, D.

    1989-01-01

    The one-loop contribution to the effective potential and mass are computed within the context of scalar electrodynamics for the class of general R gauges in the MS scheme. These calculations are performed in order to construct a non-trivial verification of the corresponding Nielsen identities within the context of the Higgs model. Some brief comments on the Coleman-Weinberg model are also included. (author) [pt

  12. Stochastic quantization and gauge invariance

    International Nuclear Information System (INIS)

    Viana, R.L.

    1987-01-01

    A survey of the fundamental ideas about Parisi-Wu's Stochastic Quantization Method, with applications to Scalar, Gauge and Fermionic theories, is done. In particular, the Analytic Stochastic Regularization Scheme is used to calculate the polarization tensor for Quantum Electrodynamics with Dirac bosons or Fermions. The regularization influence is studied for both theories and an extension of this method for some supersymmetrical models is suggested. (author)

  13. Differential renormalization of gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Aguila, F. del; Perez-Victoria, M. [Dept. de Fisica Teorica y del Cosmos, Universidad de Granada, Granada (Spain)

    1998-10-01

    The scope of constrained differential renormalization is to provide renormalized expressions for Feynman graphs, preserving at the same time the Ward identities of the theory. It has been shown recently that this can be done consistently at least to one loop for Abelian and non-Abelian gauge theories. We briefly review these results, evaluate as an example the gluon self energy in both coordinate and momentum space, and comment on anomalies. (author) 9 refs, 1 fig., 1 tab

  14. Lattice gauge theory using parallel processors

    International Nuclear Information System (INIS)

    Lee, T.D.; Chou, K.C.; Zichichi, A.

    1987-01-01

    The book's contents include: Lattice Gauge Theory Lectures: Introduction and Current Fermion Simulations; Monte Carlo Algorithms for Lattice Gauge Theory; Specialized Computers for Lattice Gauge Theory; Lattice Gauge Theory at Finite Temperature: A Monte Carlo Study; Computational Method - An Elementary Introduction to the Langevin Equation, Present Status of Numerical Quantum Chromodynamics; Random Lattice Field Theory; The GF11 Processor and Compiler; and The APE Computer and First Physics Results; Columbia Supercomputer Project: Parallel Supercomputer for Lattice QCD; Statistical and Systematic Errors in Numerical Simulations; Monte Carlo Simulation for LGT and Programming Techniques on the Columbia Supercomputer; Food for Thought: Five Lectures on Lattice Gauge Theory

  15. 4D topological mass by gauging spin

    Science.gov (United States)

    Choudhury, I. D.; Diamantini, M. Cristina; Guarnaccia, Giuseppe; Lahiri, A.; Trugenberger, Carlo A.

    2015-06-01

    We propose a spin gauge field theory in which the curl of a Dirac fermion current density plays the role of the pseudovector charge density. In this field-theoretic model, spin interactions are mediated by a single scalar gauge boson in its antisymmetric tensor formulation. We show that these long range spin interactions induce a gauge invariant photon mass in the one-loop effective action. The fermion loop generates a coupling between photons and the spin gauge boson, which acquires thus charge. This coupling represents also an induced, gauge invariant, topological mass for the photons, leading to the Meissner effect. The one-loop effective equations of motion for the charged spin gauge boson are the London equations. We propose thus spin gauge interactions as an alternative, topological mechanism for superconductivity in which no spontaneous symmetry breaking is involved.

  16. 4D topological mass by gauging spin

    Energy Technology Data Exchange (ETDEWEB)

    Choudhury, I.D. [S.N. Bose National Centre for Basic Sciences,Block JD, Sector III, Salt Lake, Kolkata, 700098 (India); Diamantini, M. Cristina [NiPS Laboratory, INFN and Dipartimento di Fisica, University of Perugia,via A. Pascoli, Perugia, I-06100 (Italy); Guarnaccia, Giuseppe [Dipartimento di Fisica “E.R. Caianiello”, Università di Salerno,via Giovanni Paolo II, Fisciano, Salerno, I-84084 (Italy); Lahiri, A. [S.N. Bose National Centre for Basic Sciences,Block JD, Sector III, Salt Lake, Kolkata, 700098 (India); Trugenberger, Carlo A. [SwissScientific,chemin Diodati 10, Cologny, CH-1223 (Switzerland)

    2015-06-12

    We propose a spin gauge field theory in which the curl of a Dirac fermion current density plays the role of the pseudovector charge density. In this field-theoretic model, spin interactions are mediated by a single scalar gauge boson in its antisymmetric tensor formulation. We show that these long range spin interactions induce a gauge invariant photon mass in the one-loop effective action. The fermion loop generates a coupling between photons and the spin gauge boson, which acquires thus charge. This coupling represents also an induced, gauge invariant, topological mass for the photons, leading to the Meissner effect. The one-loop effective equations of motion for the charged spin gauge boson are the London equations. We propose thus spin gauge interactions as an alternative, topological mechanism for superconductivity in which no spontaneous symmetry breaking is involved.

  17. 4D topological mass by gauging spin

    International Nuclear Information System (INIS)

    Choudhury, I.D.; Diamantini, M. Cristina; Guarnaccia, Giuseppe; Lahiri, A.; Trugenberger, Carlo A.

    2015-01-01

    We propose a spin gauge field theory in which the curl of a Dirac fermion current density plays the role of the pseudovector charge density. In this field-theoretic model, spin interactions are mediated by a single scalar gauge boson in its antisymmetric tensor formulation. We show that these long range spin interactions induce a gauge invariant photon mass in the one-loop effective action. The fermion loop generates a coupling between photons and the spin gauge boson, which acquires thus charge. This coupling represents also an induced, gauge invariant, topological mass for the photons, leading to the Meissner effect. The one-loop effective equations of motion for the charged spin gauge boson are the London equations. We propose thus spin gauge interactions as an alternative, topological mechanism for superconductivity in which no spontaneous symmetry breaking is involved.

  18. A gauge-invariant reorganization of thermal gauge theory

    Energy Technology Data Exchange (ETDEWEB)

    Su, Nan

    2010-07-01

    This dissertation is devoted to the study of thermodynamics for quantum gauge theories. The poor convergence of quantum field theory at finite temperature has been the main obstacle in the practical applications of thermal QCD for decades. In this dissertation I apply hard-thermal-loop perturbation theory, which is a gauge-invariant reorganization of the conventional perturbative expansion for quantum gauge theories to the thermodynamics of QED and Yang-Mills theory to three-loop order. For the Abelian case, I present a calculation of the free energy of a hot gas of electrons and photons by expanding in a power series in m{sub D}/T, m{sub f}/T and e{sup 2}, where m{sub D} and m{sub f} are the photon and electron thermal masses, respectively, and e is the coupling constant. I demonstrate that the hard-thermal-loop perturbation reorganization improves the convergence of the successive approximations to the QED free energy at large coupling, e {proportional_to} 2. For the non-Abelian case, I present a calculation of the free energy of a hot gas of gluons by expanding in a power series in m{sub D}/T and g{sup 2}, where m{sub D} is the gluon thermal mass and g is the coupling constant. I show that at three-loop order hard-thermal-loop perturbation theory is compatible with lattice results for the pressure, energy density, and entropy down to temperatures T {proportional_to} 2 - 3 T{sub c}. The results suggest that HTLpt provides a systematic framework that can be used to calculate static and dynamic quantities for temperatures relevant at LHC. (orig.)

  19. Ole1, fatty acid desaturase, is required for Atg9 delivery and isolation membrane expansion during autophagy in Saccharomyces cerevisiae

    Directory of Open Access Journals (Sweden)

    Yuta Ogasawara

    2017-01-01

    Full Text Available Macroautophagy, a major degradation pathway of cytoplasmic components, is carried out through formation of a double-membrane structure, the autophagosome. Although the involvement of specific lipid species in the formation process remains largely obscure, we recently showed that mono-unsaturated fatty acids (MUFA generated by stearoyl-CoA desaturase 1 (SCD1 are required for autophagosome formation in mammalian cells. To obtain further insight into the role of MUFA in autophagy, in this study we analyzed the autophagic phenotypes of the yeast mutant of OLE1, an orthologue of SCD1. Δole1 cells were defective in nitrogen starvation-induced autophagy, and the Cvt pathway, when oleic acid was not supplied. Defects in elongation of the isolation membrane led to a defect in autophagosome formation. In the absence of Ole1, the transmembrane protein Atg9 was not able to reach the pre-autophagosomal structure (PAS, the site of autophagosome formation. Thus, autophagosome formation requires Ole1 during the delivery of Atg9 to the PAS/autophagosome from its cellular reservoir.

  20. The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients

    DEFF Research Database (Denmark)

    Metzger, Silke; Walter, Carolin; Riess, Olaf

    2013-01-01

    The cause of Huntington disease (HD) is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify the course and the age at onset of HD. Recently......, we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second...... a modifying effect of ATG7 in these REGISTRY patients and in patients of our previous HD cohort according to their ethnic origin, we identified a significant effect of the ATG7 V471A polymorphism on the HD age at onset only in the Italian population (327 patients). In these Italian patients, the polymorphism...

  1. The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients.

    Science.gov (United States)

    Metzger, Silke; Walter, Carolin; Riess, Olaf; Roos, Raymund A C; Nielsen, Jørgen E; Craufurd, David; Nguyen, Huu Phuc

    2013-01-01

    The cause of Huntington disease (HD) is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify the course and the age at onset of HD. Recently, we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second independent patient cohort, we analysed the ATG7 V471A polymorphism in additional 1,464 European HD patients of the "REGISTRY" cohort from the European Huntington Disease Network (EHDN). In the entire REGISTRY cohort we could not confirm a modifying effect of the ATG7 V471A polymorphism. However, analysing a modifying effect of ATG7 in these REGISTRY patients and in patients of our previous HD cohort according to their ethnic origin, we identified a significant effect of the ATG7 V471A polymorphism on the HD age at onset only in the Italian population (327 patients). In these Italian patients, the polymorphism is associated with a 6-years earlier disease onset and thus seems to have an aggravating effect. We could specify the role of ATG7 as a genetic modifier for HD particularly in the Italian population. This result affirms the modifying influence of the autophagic pathway on the course of HD, but also suggests population-specific modifying mechanisms in HD pathogenesis.

  2. 46 CFR 52.01-110 - Water-level indicators, water columns, gauge-glass connections, gauge cocks, and pressure gauges...

    Science.gov (United States)

    2010-10-01

    ... § 52.01-110 Water-level indicators, water columns, gauge-glass connections, gauge cocks, and pressure... 46 Shipping 2 2010-10-01 2010-10-01 false Water-level indicators, water columns, gauge-glass connections, gauge cocks, and pressure gauges (modifies PG-60). 52.01-110 Section 52.01-110 Shipping COAST...

  3. Introduction to lattice gauge theory

    International Nuclear Information System (INIS)

    Gupta, R.

    1987-01-01

    The lattice formulation of Quantum Field Theory (QFT) can be exploited in many ways. We can derive the lattice Feynman rules and carry out weak coupling perturbation expansions. The lattice then serves as a manifestly gauge invariant regularization scheme, albeit one that is more complicated than standard continuum schemes. Strong coupling expansions: these give us useful qualitative information, but unfortunately no hard numbers. The lattice theory is amenable to numerical simulations by which one calculates the long distance properties of a strongly interacting theory from first principles. The observables are measured as a function of the bare coupling g and a gauge invariant cut-off ≅ 1/α, where α is the lattice spacing. The continuum (physical) behavior is recovered in the limit α → 0, at which point the lattice artifacts go to zero. This is the more powerful use of lattice formulation, so in these lectures the author focuses on setting up the theory for the purpose of numerical simulations to get hard numbers. The numerical techniques used in Lattice Gauge Theories have their roots in statistical mechanics, so it is important to develop an intuition for the interconnection between quantum mechanics and statistical mechanics. This will be the emphasis of the first lecture. In the second lecture, the author reviews the essential ingredients of formulating QCD on the lattice and discusses scaling and the continuum limit. In the last lecture the author summarizes the status of some of the main results. He also mentions the bottlenecks and possible directions for research. 88 refs

  4. From gauge theories to charm

    International Nuclear Information System (INIS)

    Jacob, Maurice

    1976-01-01

    The charm is a new elementary constituent introduced in the SU(4) framework to explain the properties of the psi particles; its introduction definites the essential properties of the four quarks, u, d, s, c in the SU(4) framework. The discovery of charmed particles (two mesons four quarks u,d,s,c in the SU(4) framework. The discovery of charmed particles (two mesons and one baryons) confirms a series of previsions that derive from the introduction of gauge theories: weak neutral currents, W meson, unification of weak interactions and electrodynamics. Beyonds charm the introduction of colored quarks and gluon exchanges gives to strong interactions the simplicity of electrodynamics [fr

  5. Gauge coupling unification in six dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Lee, H.M. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)]|[Carnegie-Mellon Univ., Pittsburgh, PA (United States). Dept. of Physics

    2006-11-15

    We compute the one-loop gauge couplings in six-dimensional non-Abelian gauge theories on the T{sup 2}/Z{sub 2} orbifold with general GUT breaking boundary conditions. For concreteness, we apply the obtained general formulae to the gauge coupling running in a 6D SO(10) orbifold GUT where the GUT group is broken down to the standard model gauge group up to an extra U(1). We find that the one-loop corrections depend on the parity matrices encoding the orbifold boundary conditions as well as the volume and shape moduli of extra dimensions. When the U(1) is broken by the VEV of bulk singlets, the accompanying extra color triplets also affect the unification of the gauge couplings. In this case, the B-L breaking scale is closely linked to the compactification scales for maintaining a success of the gauge coupling unification. (orig.)

  6. Factorization in QCD in Feynman gauge

    International Nuclear Information System (INIS)

    Tucci, R.R.

    1985-01-01

    We present a mass divergence power counting technique for QCD in the Feynman gauge. For the process γ/sup */ → qq, we find the leading regions of integration and show that single diagrams are at worst logarithmically divergent. Using the Weyl representation facilities the γ matrix manipulations necessary for power counting and adds much physical insight. We prove Ward type identities which are needed in the proof of factorization of the Drill Yan process. Previous treatments prove them only for an axial gauge, and the proofs are diagrammatic in nature. We, on the other hand, establish the identities for the Feynman gauge and through symmetry considerations at the Lagrangian level. The strategy is to first derive exact results in a background field gauge and then to show that to leading order in the mass divergences the background field gauge results can be used in the Feynman gauge

  7. Hidden QCD in Chiral Gauge Theories

    DEFF Research Database (Denmark)

    Ryttov, Thomas; Sannino, Francesco

    2005-01-01

    The 't Hooft and Corrigan-Ramond limits of massless one-flavor QCD consider the two Weyl fermions to be respectively in the fundamental representation or the two index antisymmetric representation of the gauge group. We introduce a limit in which one of the two Weyl fermions is in the fundamental...... representation and the other in the two index antisymmetric representation of a generic SU(N) gauge group. This theory is chiral and to avoid gauge anomalies a more complicated chiral theory is needed. This is the generalized Georgi-Glashow model with one vector like fermion. We show that there is an interesting...... phase in which the considered chiral gauge theory, for any N, Higgses via a bilinear condensate: The gauge interactions break spontaneously to ordinary massless one-flavor SU(3) QCD. The additional elementary fermionic matter is uncharged under this SU(3) gauge theory. It is also seen that when...

  8. Gauge field condensation in geometric quantum chromodynamics

    International Nuclear Information System (INIS)

    Guendelman, E.I.

    1991-09-01

    In odd number of dimensions, it is possible to construct general covariant gauge theories, where the metric is not an independent variable, but local function of the gauge fields. Starting from standardly defined gauge theory, upon functional integration of some variables, we could end up with such moodels. For models with SU(2) and SU(3) symmetry in three dimensions, gauge field condensation take place in the vacuum, which is nevertheless homogeneous and isotropic up to a gauge transformation, provided the space is flat. Introducing Higgs fields that spontaneously break the gauge symmetry, we get a breakdown of the homogenity and isotropy of the vacuum. Finally, we discuss how some of this ideas can be generalized to four and other even dimensions. (author)

  9. Recursive relations for a quiver gauge theory

    International Nuclear Information System (INIS)

    Park, Jaemo; Sim, Woojoo

    2006-01-01

    We study the recursive relations for a quiver gauge theory with the gauge group SU(N 1 ) x SU(N 2 ) with bifundamental fermions transforming as (N 1 , N-bar 2 ). We work out the recursive relation for the amplitudes involving a pair of quark and antiquark and gluons of each gauge group. We realize directly in the recursive relations the invariance under the order preserving permutations of the gluons of the first and the second gauge group. We check the proposed relations for MHV, 6-point and 7-point amplitudes and find the agreements with the known results and the known relations with the single gauge group amplitudes. The proposed recursive relation is much more efficient in calculating the amplitudes than using the known relations with the amplitudes of the single gauge group

  10. Noncommutative induced gauge theories on Moyal spaces

    International Nuclear Information System (INIS)

    Wallet, J-C

    2008-01-01

    Noncommutative field theories on Moyal spaces can be conveniently handled within a framework of noncommutative geometry. Several renormalisable matter field theories that are now identified are briefly reviewed. The construction of renormalisable gauge theories on these noncommutative Moyal spaces, which remains so far a challenging problem, is then closely examined. The computation in 4-D of the one-loop effective gauge theory generated from the integration over a scalar field appearing in a renormalisable theory minimally coupled to an external gauge potential is presented. The gauge invariant effective action is found to involve, beyond the expected noncommutative version of the pure Yang-Mills action, additional terms that may be interpreted as the gauge theory counterpart of the harmonic term, which for the noncommutative ψ 4 -theory on Moyal space ensures renormalisability. A class of possible candidates for renormalisable gauge theory actions defined on Moyal space is presented and discussed

  11. Gauge independence of the Ao-condensate

    International Nuclear Information System (INIS)

    Skalozub, V.V.

    1992-01-01

    The problem of gauge dependence of the zero gauge field component condensate. A o =const, in the framework of finite temperature SU(2) gluodynamics is investigated. In straight-forward calculations it is shown that the two-loop effective action W(A o ,ζ) satisfies the generalized Nielsen identity. Thus, the gauge invariance of the A o -condensation is proved. 12 refs. (author)

  12. Gauge and parametrization ambiguity in quantum gravity

    Science.gov (United States)

    Gonçalves, Jeferson D.; Netto, Tibério de Paula; Shapiro, Ilya L.

    2018-01-01

    The gauge and parametrization dependence is discussed in quantum gravity in an arbitrary dimension D . Explicit one-loop calculations are performed within the most general parametrization of quantum metric with seven arbitrary parameters. On the other hand, some of the gauge fixing parameters are fixed to make the calculations relatively simple. We confirm the general theorem stating that the on shell local terms in the one-loop effective action are independent of the gauge and parametrization ambiguity.

  13. Alpha-particle Gas Pressure Gauge

    Science.gov (United States)

    Buehler, M. G.; Bell, L. D.; Hecht, M. H.

    1995-01-01

    Described are preliminary results obtained on a novel gas pressure gauge that operates between 0.1 and 1000 mb. This gauge uses a 1- micron Ci alpha particle source to ionize the gas in a small chamber with an electric field imposed between anode and cathode electrodes that drives positive ions to the cathode where they are collected electronically. This gauge could make Martian pressure measurements.

  14. Electroweak Measurements with Multiple Gauge Boson Interactions

    CERN Document Server

    Sood, A; The ATLAS collaboration

    2014-01-01

    This talk presents measurements from ATLAS and CMS that are sensitive interactions between EW gauge bosons. Included analyses sensitive to triple gauge couplings are EW $Z$ production, and $VV^{\\prime}$ cross sections where $V=W/Z$ and $V^{\\prime}=W/Z/\\gamma$, while $\\gamma\\gamma\\rightarrow WW$, $WV\\gamma$ where $V=W/Z$, and $W^{\\pm}W^{\\pm}jj$ production are present as probes of quartic gauge couplings.

  15. Scattering amplitudes in gauge theories

    International Nuclear Information System (INIS)

    Henn, Johannes M.; Plefka, Jan C.

    2014-01-01

    First monographical text on this fundamental topic. Course-tested, pedagogical and self-contained exposition. Includes exercises and solutions. At the fundamental level, the interactions of elementary particles are described by quantum gauge field theory. The quantitative implications of these interactions are captured by scattering amplitudes, traditionally computed using Feynman diagrams. In the past decade tremendous progress has been made in our understanding of and computational abilities with regard to scattering amplitudes in gauge theories, going beyond the traditional textbook approach. These advances build upon on-shell methods that focus on the analytic structure of the amplitudes, as well as on their recently discovered hidden symmetries. In fact, when expressed in suitable variables the amplitudes are much simpler than anticipated and hidden patterns emerge. These modern methods are of increasing importance in phenomenological applications arising from the need for high-precision predictions for the experiments carried out at the Large Hadron Collider, as well as in foundational mathematical physics studies on the S-matrix in quantum field theory. Bridging the gap between introductory courses on quantum field theory and state-of-the-art research, these concise yet self-contained and course-tested lecture notes are well-suited for a one-semester graduate level course or as a self-study guide for anyone interested in fundamental aspects of quantum field theory and its applications. The numerous exercises and solutions included will help readers to embrace and apply the material presented in the main text.

  16. Form measurements in an industrial CT scanner investigated using a polymer step gauge

    DEFF Research Database (Denmark)

    Angel, J.; Stolfi, Alessandro; De Chiffre, Leonardo

    2015-01-01

    Computed Tomography (CT) is a promising technology for both geometrical measurements and form measurements. However, a number of influence factors such as magnification, threshold determination strategies, and position of feature in the CT volume, have effect on the CT measurement performance...... error and good surface finish. A total of 132 flatness measurements were performed on the left step gauge grooves. The linear distribution of the grooves pointed out a non-uniform CT performance over the step gauge length with max deviation up to 25 μm. However, an appropriate choice of parameters...... yielded a reduction of the max deviation along the step gauge length by approximately 13 μm....

  17. Focus point supersymmetry in extended gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Ran [School of Physics, Nankai University,Tianjin 300071 (China); Li, Tianjun [State Key Laboratory of Theoretical Physics and Kavli Institute for Theoretical Physics (KITPC),Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190 (China); School of Physical Electronics, University of Electronic Science and Technology of China,Chengdu 610054 (China); Staub, Florian [Bethe Center for Theoretical Physics & Physikalisches Institut der Universität Bonn,Nußallee 12, 53115 Bonn (Germany); Zhu, Bin [School of Physics, Nankai University,Tianjin 300071 (China)

    2014-03-27

    We propose a small extension of the minimal gauge mediation through the combination of extended gauge mediation and conformal sequestering. We show that the focus point supersymmetry can be realized naturally, and the fine tuning is significantly reduced compared to the minimal gauge mediation and extended gauge mediation without focus point. The Higgs boson mass is around 125 GeV, the gauginos remain light, and the gluino is likely to be detected at the next run of the LHC. However, the multi-TeV squarks is out of the reach of the LHC. The numerical calculation for fine-tuning shows that this model remains natural.

  18. Focus point supersymmetry in extended gauge mediation

    International Nuclear Information System (INIS)

    Ding, Ran; Li, Tianjun; Staub, Florian; Zhu, Bin

    2014-01-01

    We propose a small extension of the minimal gauge mediation through the combination of extended gauge mediation and conformal sequestering. We show that the focus point supersymmetry can be realized naturally, and the fine tuning is significantly reduced compared to the minimal gauge mediation and extended gauge mediation without focus point. The Higgs boson mass is around 125 GeV, the gauginos remain light, and the gluino is likely to be detected at the next run of the LHC. However, the multi-TeV squarks is out of the reach of the LHC. The numerical calculation for fine-tuning shows that this model remains natural

  19. Anomalous gauge theories as constrained Hamiltonian systems

    International Nuclear Information System (INIS)

    Fujiwara, T.

    1989-01-01

    Anomalous gauge theories considered as constrained systems are investigated. The effects of chiral anomaly on the canonical structure are examined first for nonlinear σ-model and later for fermionic theory. The breakdown of the Gauss law constraints and the anomalous commutators among them are studied in a systematic way. An intrinsic mass term for gauge fields makes it possible to solve the Gauss law relations as second class constraints. Dirac brackets between the time components of gauge fields are shown to involve anomalous terms. Based upon the Ward-Takahashi identities for gauge symmetry, we investigate anomalous fermionic theory within the framework of path integral approach. (orig.)

  20. Regularization of the light-cone gauge gluon propagator singularities using sub-gauge conditions

    Science.gov (United States)

    Chirilli, Giovanni A.; Kovchegov, Yuri V.; Wertepny, Douglas E.

    2015-12-01

    Perturbative QCD calculations in the light-cone gauge have long suffered from the ambiguity associated with the regularization of the poles in the gluon propagator. In this work we study sub-gauge conditions within the light-cone gauge corresponding to several known ways of regulating the gluon propagator. Using the functional integral calculation of the gluon propagator, we rederive the known sub-gauge conditions for the θ-function gauges and identify the sub-gauge condition for the principal value (PV) regularization of the gluon propagator's light-cone poles. The obtained sub-gauge condition for the PV case is further verified by a sample calculation of the classical Yang-Mills field of two collinear ultrarelativistic point color charges. Our method does not allow one to construct a sub-gauge condition corresponding to the well-known Mandelstam-Leibbrandt prescription for regulating the gluon propagator poles.

  1. Electromagnetic velocity gauge: use of multiple gauges, time response, and flow perturbations

    International Nuclear Information System (INIS)

    Erickson, L.M.; Johnson, C.B.; Parker, N.L.; Vantine, H.C.; Weingart, R.C.; Lee, R.S.

    1981-01-01

    We have developed an in-situ electromagnetic velocity (EMV) gauge system for use in multiple-gauge studies of initiating and detonating explosives. We have also investigated the risetime of the gauge and the manner in which it perturbs a reactive flow. We report on the special precautions that are necessary in multiple gauge experiments to reduce lead spreading, simplify target fabrication problems and minimize cross talk through the conducting explosive. Agreement between measured stress records and calculations from multiple velocity gauge data give us confidence that our velocity gauges are recording properly. We have used laser velocity interferometry to measure the gauge risetime in polymethyl methacrylate (PMMA). To resolve the difference in the two methods, we have examined hydrodynamic and material rate effects. In addition, we considered the effects of shock tilt, electronic response and magntic diffusion on the gauge's response time

  2. Review of non-nuclear density gauges as possible replacements for ITD's nuclear density gauges.

    Science.gov (United States)

    2015-01-01

    This report examines the possibility of replacing nuclear density gauges (NDGs) with non-nuclear density gauges (NNDGs) to : measure density of hot mix asphalt (HMA) and unbound pavement layers in the field. The research team evaluated the : effectiv...

  3. Extended gauge sectors at future colliders: Report of the New Gauge Boson Subgroup

    International Nuclear Information System (INIS)

    Rizzo, T.G.

    1996-12-01

    The author summarizes the results of the New Gauge Boson Subgroup on the physics of extended gauge sectors at future colliders as presented at the 1996 Snowmass workshop. He discusses the direct and indirect search reaches for new gauge bosons at both hadron and lepton colliders as well as the ability of such machines to extract detailed information on the couplings of these particles to the fermions and gauge bosons of the Standard Model. 41 refs., 18 figs., 5 tabs

  4. Flat epithelial atypia: comparison between 9-gauge and 11-gauge devices.

    Science.gov (United States)

    Villa, Alessandro; Chiesa, Fabio; Massa, Tiberio; Friedman, Daniele; Canavese, Giuseppe; Baccini, Paola; Calabrese, Massimo; Tagliafico, Alberto

    2013-12-01

    This study aimed to establish if women with a diagnosis of flat epithelial atypia (FEA) without residual microcalcifications at stereotactic vacuum-assisted breast biopsy (VABB) could be managed with mammographic follow-up (FU) instead of surgery and to compare 9-gauge and 11-gauge devices. From October 2003 to January 2011, 2382 VABB procedures were performed (1373 with 11-gauge and 1009 with 9-gauge). We found 121 cases of pure FEA that were surgically treated: 57 with a 9-gauge device (group 1) and 64 with an 11-gauge device (group 2). The underestimation rate (UR) of malignancy for patients without and those with residual microcalcifications for each VABB device was calculated. Differences between groups were analyzed with the Fischer exact test. The overall UR of FEA was 4% (2 of 57) with the 9-gauge device and 8% (5 of 64) with the 11-gauge device. With a 9-gauge device, the UR for patients without residual microcalcifications was 0% (0 of 46), and the UR for patients with residual microcalcifications was 18% (2 of 11). With an 11-gauge device, the UR for patients without residual microcalcifications was 0% (0 of 39), the UR for patients with residual microcalcifications at post-biopsy mammograms was 16% (5 of 25). With a 9-gauge device, 80% (46 of 57) of patients did not have residual microcalcifications after VABB. With an 11-gauge device, 60% (39 of 64) of patients had no residual microcalcifications after VABB. Differences between the 9-gauge and 11-gauge devices were statistically significant (P gauge VABB is associated with a lower percentage of residual microcalcifications compared with an 11-gauge device, but it is safe to follow patients with FEA if all calcifications are removed with the core biopsy. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. 46 CFR 154.1320 - Sighting ports, tubular gauge glasses, and flat plate type gauge glasses.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Sighting ports, tubular gauge glasses, and flat plate type gauge glasses. 154.1320 Section 154.1320 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... LIQUEFIED GASES Design, Construction and Equipment Instrumentation § 154.1320 Sighting ports, tubular gauge...

  6. A Prospective Comparison of EUS-Guided FNA Using 25-Gauge and 22-Gauge Needles

    Science.gov (United States)

    Imazu, Hiroo; Uchiyama, Yujiro; Kakutani, Hiroshi; Ikeda, kei-ichi; Sumiyama, Kazuki; Kaise, Mitsuru; Omar, Salem; Ang, Tiing Leong; Tajiri, Hisao

    2009-01-01

    Background and Aims. There are limited data on the differences in diagnostic yield between 25-gauge and 22-gauge EUS-FNA needles. This prospective study compared the difference in diagnostic yield between a 22-gauge and a 25-gauge needle when performing EUS-FNA. Methods. Forty-three patients with intraluminal or extraluminal mass lesions and/or lymphadenopathy were enrolled prospectively. EUS-FNA was performed for each mass lesion using both 25- and 22-gauge needles. The differences in accuracy rate, scoring of needle visibility, ease of puncture and quantity of obtained specimen were evaluated. Results. The overall accuracy of 22- and 25-gauge needle was similar at 81% and 76% respectively (N.S). Likewise the visibility scores of both needles were also similar. Overall the quantity of specimen obtained higher with the 22-gauge needle (score: 1.64 vs. P < .001). However the 25-gauge needle was significantly superior to the 22-gauge needle in terms of ease of puncture (score: 1.9 vs. 1.29, P < .001) and in the quantity of specimen in the context of pancreatic mass EUS-FNA (score: 1.8 vs. 1.58, P < .05). Conclusion. The 22-gauge and 25-gauge needles have similar overall diagnostic yield. The 25-gauge needle appeared superior in the subset of patients with hard lesions and pancreatic masses. PMID:19997511

  7. A Prospective Comparison of EUS-Guided FNA Using 25-Gauge and 22-Gauge Needles

    Directory of Open Access Journals (Sweden)

    Hiroo Imazu

    2009-01-01

    Full Text Available Background and Aims. There are limited data on the differences in diagnostic yield between 25-gauge and 22-gauge EUS-FNA needles. This prospective study compared the difference in diagnostic yield between a 22-gauge and a 25-gauge needle when performing EUS-FNA. Methods. Forty-three patients with intraluminal or extraluminal mass lesions and/or lymphadenopathy were enrolled prospectively. EUS-FNA was performed for each mass lesion using both 25- and 22-gauge needles. The differences in accuracy rate, scoring of needle visibility, ease of puncture and quantity of obtained specimen were evaluated. Results. The overall accuracy of 22- and 25-gauge needle was similar at 81% and 76% respectively (N.S. Likewise the visibility scores of both needles were also similar. Overall the quantity of specimen obtained higher with the 22-gauge needle (score: 1.64 vs. P<.001. However the 25-gauge needle was significantly superior to the 22-gauge needle in terms of ease of puncture (score: 1.9 vs. 1.29, P<.001 and in the quantity of specimen in the context of pancreatic mass EUS-FNA (score: 1.8 vs. 1.58, P<.05. Conclusion. The 22-gauge and 25-gauge needles have similar overall diagnostic yield. The 25-gauge needle appeared superior in the subset of patients with hard lesions and pancreatic masses.

  8. Gauge-fixing parameter dependence of two-point gauge-variant correlation functions

    International Nuclear Information System (INIS)

    Zhai, C.

    1996-01-01

    The gauge-fixing parameter ξ dependence of two-point gauge-variant correlation functions is studied for QED and QCD. We show that, in three Euclidean dimensions, or for four-dimensional thermal gauge theories, the usual procedure of getting a general covariant gauge-fixing term by averaging over a class of covariant gauge-fixing conditions leads to a nontrivial gauge-fixing parameter dependence in gauge-variant two-point correlation functions (e.g., fermion propagators). This nontrivial gauge-fixing parameter dependence modifies the large-distance behavior of the two-point correlation functions by introducing additional exponentially decaying factors. These factors are the origin of the gauge dependence encountered in some perturbative evaluations of the damping rates and the static chromoelectric screening length in a general covariant gauge. To avoid this modification of the long-distance behavior introduced by performing the average over a class of covariant gauge-fixing conditions, one can either choose a vanishing gauge-fixing parameter or apply an unphysical infrared cutoff. copyright 1996 The American Physical Society

  9. The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines.

    Science.gov (United States)

    Wildenberg, M E; Koelink, P J; Diederen, K; Te Velde, A A; Wolfkamp, S C S; Nuij, V J; Peppelenbosch, M P; Nobis, M; Sansom, O J; Anderson, K I; van der Woude, C J; D'Haens, G R A M; van den Brink, G R

    2017-03-01

    Thiopurines are commonly used drugs in the therapy of Crohn's disease, but unfortunately only show a 30% response rate. The biological basis for the thiopurine response is unclear, thus hampering patient selection prior to treatment. A genetic risk factor associated specifically with Crohn's disease is a variant in ATG16L1 that reduces autophagy. We have previously shown that autophagy is involved in dendritic cell (DC)-T-cell interactions and cytoskeletal regulation. Here we further investigated the role of autophagy in DC cytoskeletal modulation and cellular trafficking. Autophagy-deficient DC displayed loss of filopodia, altered podosome distribution, and increased membrane ruffling, all consistent with increased cellular adhesion. Consequently, autophagy-deficient DC showed reduced migration. The cytoskeletal aberrations were mediated through hyperactivation of Rac1, a known thiopurine target. Indeed thiopurines restored the migratory defects in autophagy-deficient DC. Clinically, the ATG16L1 risk variant associated with increased response to thiopurine treatment in patients with Crohn's disease but not ulcerative colitis. These results suggest that the association between ATG16L1 and Crohn's disease is mediated at least in part through Rac1 hyperactivation and subsequent defective DC migration. As this phenotype can be corrected using thiopurines, ATG16L1 genotyping may be useful in the identification of patients that will benefit most from thiopurine treatment.

  10. HucMSC exosomes-delivered 14-3-3ζ enhanced autophagy via modulation of ATG16L in preventing cisplatin-induced acute kidney injury.

    Science.gov (United States)

    Jia, Haoyuan; Liu, Wanzhu; Zhang, Bin; Wang, Juanjuan; Wu, Peipei; Tandra, Nitin; Liang, Zhaofeng; Ji, Cheng; Yin, Lei; Hu, Xinyuan; Yan, Yongmin; Mao, Fei; Zhang, Xu; Yu, Jing; Xu, Wenrong; Qian, Hui

    2018-01-01

    The clinical application of cisplatin is restricted by its side effects of nephrotoxicity. Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-ex) have an important effect in tissue injury repair. Our previous work discovered that pretreatment with human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-ex) alleviated cisplatin-induced acute kidney injury (AKI) by activating autophagy both in vitro and in vivo . In this study, we further explored the mechanisms of hucMSC-ex in autophagy for preventing cisplatin-induced nephrotoxicity. We discovered that 14-3-3ζ was contained in hucMSC-ex, and knockdown and overexpression 14-3-3ζ reduced and enhanced the autophagic activity respectively. Furthermore, Knockdown of 14-3-3ζ alleviated the preventive effect of hucMSC-ex. In contrast, overexpression of 14-3-3ζ enhanced the effect. Further results confirmed that hucMSC-ex increased ATG16L expression and that 14-3-3ζ interacted with ATG16L, promoting the localization of ATG16L at autophagosome precursors. In this study, we revealed that hucMSC-ex-delivered 14-3-3ζ interacted with ATG16L to activate autophagy. Our findings suggest that 14-3-3ζ is a novel mechanism for MSC-exosomes-activated autophagy and provides a new strategy for the prevention of cisplatin-induced nephrotoxicity.

  11. Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!

    Science.gov (United States)

    Pearson, Christopher E

    2011-03-01

    Diseases associated with unstable repetitive elements in the DNA, RNA, and amino acids have consistently revealed scientific surprises. Most diseases are caused by expansions of trinucleotide repeats, which ultimately lead to diseases like Huntington's disease, myotonic dystrophy, fragile X syndrome, and a series of spinocerebellar ataxias. These repeat mutations are dynamic, changing through generations and within an individual, and the repeats can be bi-directionally transcribed. Unsuspected modes of pathogenesis involve aberrant loss of protein expression; aberrant over-expression of non-mutant proteins; toxic-gain-of-protein function through expanded polyglutamine tracts that are encoded by expanded CAG tracts; and RNA-toxic-gain-of-function caused by transcripts harboring expanded CUG, CAG, or CGG tracts. A recent advance reveals that RNA transcripts with expanded CAG repeats can be translated in the complete absence of a starting ATG, and this Repeat Associated Non-ATG translation (RAN-translation) occurs across expanded CAG repeats in all reading frames (CAG, AGC, and GCA) to produce homopolymeric proteins of long polyglutamine, polyserine, and polyalanine tracts. Expanded CTG tracts expressing CUG transcripts also show RAN-translation occurring in all three frames (CUG, UGC, and GCU), to produce polyleucine, polycysteine, and polyalanine. These RAN-translation products can be toxic. Thus, one unstable (CAG)•(CTG) DNA can produce two expanded repeat transcripts and homopolymeric proteins with reading frames (the AUG-directed polyGln and six RAN-translation proteins), yielding a total of potentially nine toxic entities. The occurrence of RAN-translation in patient tissues expands our horizons of modes of disease pathogenesis. Moreover, since RAN-translation counters the canonical requirements of translation initiation, many new questions are now posed that must be addressed. This review covers RAN-translation and some of the pertinent questions.

  12. Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!

    Directory of Open Access Journals (Sweden)

    Christopher E Pearson

    2011-03-01

    Full Text Available Diseases associated with unstable repetitive elements in the DNA, RNA, and amino acids have consistently revealed scientific surprises. Most diseases are caused by expansions of trinucleotide repeats, which ultimately lead to diseases like Huntington's disease, myotonic dystrophy, fragile X syndrome, and a series of spinocerebellar ataxias. These repeat mutations are dynamic, changing through generations and within an individual, and the repeats can be bi-directionally transcribed. Unsuspected modes of pathogenesis involve aberrant loss of protein expression; aberrant over-expression of non-mutant proteins; toxic-gain-of-protein function through expanded polyglutamine tracts that are encoded by expanded CAG tracts; and RNA-toxic-gain-of-function caused by transcripts harboring expanded CUG, CAG, or CGG tracts. A recent advance reveals that RNA transcripts with expanded CAG repeats can be translated in the complete absence of a starting ATG, and this Repeat Associated Non-ATG translation (RAN-translation occurs across expanded CAG repeats in all reading frames (CAG, AGC, and GCA to produce homopolymeric proteins of long polyglutamine, polyserine, and polyalanine tracts. Expanded CTG tracts expressing CUG transcripts also show RAN-translation occurring in all three frames (CUG, UGC, and GCU, to produce polyleucine, polycysteine, and polyalanine. These RAN-translation products can be toxic. Thus, one unstable (CAG•(CTG DNA can produce two expanded repeat transcripts and homopolymeric proteins with reading frames (the AUG-directed polyGln and six RAN-translation proteins, yielding a total of potentially nine toxic entities. The occurrence of RAN-translation in patient tissues expands our horizons of modes of disease pathogenesis. Moreover, since RAN-translation counters the canonical requirements of translation initiation, many new questions are now posed that must be addressed. This review covers RAN-translation and some of the pertinent

  13. 27 CFR 30.45 - Withdrawal gauge for packages.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Withdrawal gauge for... BUREAU, DEPARTMENT OF THE TREASURY LIQUORS GAUGING MANUAL Gauging Procedures Determination of Quantity by Weight § 30.45 Withdrawal gauge for packages. When wooden packages are to be individually gauged for...

  14. Gauge Trimming of Neutrino Masses

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Mu-Chun; /Fermilab /UC, Irvine; de Gouvea, Andre; /Northwestern U. /Fermilab; Dobrescu, Bogdan A.; /Fermilab

    2006-12-01

    We show that under a new U(1) gauge symmetry, which is non-anomalous in the presence of one ''right-handed neutrino'' per generation and consistent with the standard model Yukawa couplings, the most general fermion charges are determined in terms of four rational parameters. This generalization of the B-L symmetry with generation-dependent lepton charges leads to neutrino masses induced by operators of high dimensionality. Neutrino masses are thus naturally small without invoking physics at energies above the TeV scale, whether neutrinos are Majorana or Dirac fermions. This ''Leptocratic'' Model predicts the existence of light quasi-sterile neutrinos with consequences for cosmology, and implies that collider experiments may reveal the origin of neutrino masses.

  15. Gauge-symmetry hierarchies revisited

    International Nuclear Information System (INIS)

    Gildener, E.

    1979-01-01

    It was shown by the author in a previous paper that in each order of perturbation theory there is an upper bound on the range of validity of a gauge hierarchy. Thus constructing a large hierarchy requires a fine-tuning of the scalar-field parameters. It was stated that the possibility of an inherent bound on the hierarchy exists, but the question of the actual existence of such a bound was left completely open. Since then several authors have addressed this problem. Some of what the author asserted was misunderstood, and incorrect conclusions have been drawn from recent computations. It has been claimed that the existence of large hierarchies has been demonstrated. It is the purpose of this paper to refute this claim, to help clarify the situation, and to explain why the status of this problem has in fact not really changed in recent years (author)

  16. An introduction to gauge theories

    International Nuclear Information System (INIS)

    Iliopoulos, J.

    1977-01-01

    The CERN-JINR School of Physics is meant to give young experimental physicists an introduction to the theoretical aspects of recent advances in elementary particle physics. This paper presents an introduction to gauge theories: the systematics of Yang-Mills theories, spontaneous symmetry breaking, and Higgs mechanism. The treatment is simple, stressing the general principles rather than detailed calculations. The author presents the Weinberg-Salam model as an example of a renormalizable theory of weak and electromagnetic interactions of leptons, and it is shown that the extension of these ideas into the hadronic world requires the introduction of charm and colour. Finally, an attempt is made to include strong interactions into the scheme, guided by the experimental results of deep-inelastic lepton-nucleon scattering. The Callan-Symanzik equation, and the concepts of asymptotic freedom and quark confinement are introduced. (Auth.)

  17. An introduction to gauge theories

    International Nuclear Information System (INIS)

    Iliopoulos, J.

    1976-01-01

    These lecture notes present an introduction to gauge theories: the systematics of Yang-Mills theories, spontaneous symmetry breaking, and Higgs mechanism. The treatment is simple, stressing the general principles rather than detailed calculations. We present the Weinberg-Salam model as an example of a renormalizable theory of weak and electromagnetic interactions of leptons, and we show that the extension of these ideas into the hadronic world requires the introduction of charm and colour. Finally, we try to include strong interactions into the scheme, guided by the experimental results of deep-inelastic lepton-nucleon scattering. We derive and solve the Callan-Symanzik equation, and we introduce the concepts of asymptotic freedom and quark confinement. (Author)

  18. Contemporary status of gauge fields

    International Nuclear Information System (INIS)

    Slavnov, A.A.

    1979-01-01

    A successive and a self-consistent scheme of calculation is developed for the Yang-Mills theory. Boundary conditions related to the problem on the physical vacuum are predetermined for solving the field theory equations. It is noted that the principal problem for the Yang-Mills theory consists in finding the actual ground state. The role of instantons in constructing the gauge field ground state and of the dynamic mechanism of quark confinement are also discussed. An assumption has been made that the Yang-Mills theory can be solved exactly. This assumption is based on analogy between the Yang-Mills theory and the two-dimensional nonlinear σ-model. An exceptionality of the Yang-Mills theory is stressed which consists in the fact that it is a unique massless vector field theory in which no patologies are observed connected with nonpositive determination of energy

  19. Simple scheme for gauge mediation

    International Nuclear Information System (INIS)

    Murayama, Hitoshi; Nomura, Yasunori

    2007-01-01

    We present a simple scheme for constructing models that achieve successful gauge mediation of supersymmetry breaking. In addition to our previous work [H. Murayama and Y. Nomura, Phys. Rev. Lett. 98, 151803 (2007)] that proposed drastically simplified models using metastable vacua of supersymmetry breaking in vectorlike theories, we show there are many other successful models using various types of supersymmetry-breaking mechanisms that rely on enhanced low-energy U(1) R symmetries. In models where supersymmetry is broken by elementary singlets, one needs to assume U(1) R violating effects are accidentally small, while in models where composite fields break supersymmetry, emergence of approximate low-energy U(1) R symmetries can be understood simply on dimensional grounds. Even though the scheme still requires somewhat small parameters to sufficiently suppress gravity mediation, we discuss their possible origins due to dimensional transmutation. The scheme accommodates a wide range of the gravitino mass to avoid cosmological problems

  20. Towards the natural gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Ran [Center for High-Energy Physics, Peking University,Beijing, 100871 (China); Li, Tianjun [State Key Laboratory of Theoretical Physics andKavli Institute for Theoretical Physics, China (KITPC), Institute of Theoretical Physics,Chinese Academy of Sciences, Beijing 100190 (China); School of Physical Electronics, University of Electronic Science and Technology of China,Chengdu 610054 (China); Wang, Liucheng [Bartol Research Institute, Department of Physics and Astronomy,University of Delaware, Newark, DE 19716 (United States); Zhu, Bin [State Key Laboratory of Theoretical Physics andKavli Institute for Theoretical Physics, China (KITPC), Institute of Theoretical Physics,Chinese Academy of Sciences, Beijing 100190 (China); Institute of Physics Chinese Academy of sciences,Beijing 100190 (China)

    2015-10-23

    The sweet spot supersymmetry (SUSY) solves the μ/B{sub μ} problem in the Minimal Supersymmetric Standard Model (MSSM) with gauge mediated SUSY breaking (GMSB) via the generalized Giudice-Masiero (GM) mechanism where only the μ-term and soft Higgs masses are generated at the unification scale of the Grand Unified Theory (GUT) due to the approximate PQ symmetry. Because all the other SUSY breaking soft terms are generated via the GMSB below the GUT scale, there exists SUSY electroweak (EW) fine-tuning problem to explain the 125 GeV Higgs boson mass due to small trilinear soft term. Thus, to explain the Higgs boson mass, we propose the GMSB with both the generalized GM mechanism and Higgs-messenger interactions. The renormalization group equations are runnings from the GUT scale down to EW scale. So the EW symmetry breaking can be realized easier. We can keep the gauge coupling unification and solution to the flavor problem in the GMSB, as well as solve the μ/B{sub μ}-problem. Moreover, there are only five free parameters in our model. So we can determine the characteristic low energy spectra and explore its distinct phenomenology. The fine-tuning measure can be as low as 100. For some benchmark points, the stop mass can be as low as 1.7 TeV while the glunio mass is around 2.5 TeV. The gravitino dark matter can come from a thermal production with the correct relic density and be consistent with the thermal leptogenesis. Because gluino and stop can be relatively light in our model, how to search for such GMSB at the upcoming run II of the LHC experiment could be very interesting.

  1. Gaugings at angles from orientifold reductions

    NARCIS (Netherlands)

    Roest, D.

    2009-01-01

    We consider orientifold reductions to N = 4 gauged supergravity in four dimensions. A special feature of this theory is that different factors of the gauge group can have relative angles with respect to the electro-magnetic SL(2) symmetry. These are crucial for moduli stabilization and de Sitter

  2. Dualiy for Z(N) gauge theories

    International Nuclear Information System (INIS)

    Korthals Altes, C.P.

    1978-04-01

    The duality properties of simple Z(N) gauge theories are discussed. For N 4 these systems are not self dual. Also the order parameter is discussed. The general Z(N) gauge theory is found to be self dual for all N

  3. Effective Lagrangian density in gauge supersymmetry

    International Nuclear Information System (INIS)

    Chang, S.S.

    1976-01-01

    In the framework of gauge supersymmetry proposed by Arnowitt and Nath, an effective Lagrangian density is formally rewritten in terms of a spontaneously broken vacuum metric and the remaining perturbative part in the gauge metric tensor. Tensor notations in the superspace are revised so that all sign factors of Grassmann parities appear more systematically

  4. Milne boost from Galilean gauge theory

    Science.gov (United States)

    Banerjee, Rabin; Mukherjee, Pradip

    2018-03-01

    Physical origin of Milne boost invariance of the Newton Cartan spacetime is traced to the effect of local Galilean boosts in its metric structure, using Galilean gauge theory. Specifically, we do not require any gauge field to understand Milne boost invariance.

  5. Flux compactifications, gauge algebras and De Sitter

    NARCIS (Netherlands)

    Dibitetto, Giuseppe; Linares, Roman; Roest, Diederik

    2010-01-01

    The introduction of (non-)geometric fluxes allows for N = 1 moduli stabilisation in a De Sitter vacuum. The aim of this Letter is to assess to what extent this is true in N = 4 compactifications. First we identify the correct gauge algebra in terms of gauge and (non-)geometric fluxes. We then show

  6. 49 CFR 230.73 - Air gauges.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Air gauges. 230.73 Section 230.73 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Steam Locomotives and Tenders Brake and Signal Equipment § 230.73 Air gauges....

  7. Н(1) Gauge theory as quantum hydrodynamics

    Indian Academy of Sciences (India)

    The path inte- gral approach is used to compute the partition function. When gauge fields are included, the constraint brought about by gauge invariance simply means .... (7). A¼ = A + ∇A. (8). In order to find an action invariant under these transformations, we replace deriva- tives by covariant derivatives (minimal coupling).

  8. Transforming to Lorentz gauge on de Sitter

    NARCIS (Netherlands)

    Miao, S. P.; Tsamis, N.C.; Woodard, R.P.

    2009-01-01

    We demonstrate that certain gauge fixing functionals cannot be added to the action on backgrounds such as de Sitter, in which a linearization instability is present. We also construct the field-dependent gauge transformation that carries the electromagnetic vector potential from a convenient, non-de

  9. Lectures on quantization of gauge systems

    NARCIS (Netherlands)

    Reshetikhin, N.; Booß-Bavnbek, B.; Esposito, G.; Lesch, M.

    2010-01-01

    A gauge system is a classical field theory where among the fields there are connections in a principal G-bundle over the space - time manifold and the classical action is either invariant or transforms appropriately with respect to the action of the gauge group. The lectures are focused on the path

  10. Infrared behaviors of SU(2 gauge theory

    Directory of Open Access Journals (Sweden)

    Tuominen Kimmo

    2017-01-01

    Full Text Available We will discuss some recent results in the determination of the location of the conformal window in SU(2 gauge theory with Nf fermions in the fundamental representation of the gauge group. In particular, we will demonstrate that the long distance behavior of the continuum theory with Nf = 6 is governed by an infrared stable fixed point.

  11. Abelian gauge potentials on cubic lattices

    DEFF Research Database (Denmark)

    Burrello, M.; Lepori, L.; Paganelli, S.

    2017-01-01

    fields in a system of ultracold atoms in optical lattices. After reviewing two of the main experimental schemes for the physical realization of synthetic gauge potentials in ultracold setups, we study cubic lattice tight-bindingmodels with commensurate flux.We finally discuss applications of gauge...

  12. Class of integrable metrics and gauge fields

    Science.gov (United States)

    Almeida, Gabriel Luz; Batista, Carlos

    2017-10-01

    Starting with the most general four-dimensional spacetime possessing two commuting Killing vectors and a nontrivial Killing tensor, we analytically integrate Einstein-Yang-Mills equations for a completely arbitrary gauge group. It is assumed that the gauge field inherits the symmetries of the background and is aligned with the principal null directions of the spacetime.

  13. Soft covariant gauges on the lattice

    Energy Technology Data Exchange (ETDEWEB)

    Henty, D.S.; Oliveira, O.; Parrinello, C.; Ryan, S. [Department of Physics and Astronomy, University of Edinburgh, Edinburgh EH9 3JZ, Scotland (UKQCD Collaboration)

    1996-12-01

    We present an exploratory study of a one-parameter family of covariant, nonperturbative lattice gauge-fixing conditions that can be implemented through a simple Monte Carlo algorithm. We demonstrate that at the numerical level the procedure is feasible, and as a first application we examine the gauge dependence of the gluon propagator. {copyright} {ital 1996 The American Physical Society.}

  14. Generalized Coulomb gauge without Gribov ambiguity

    Energy Technology Data Exchange (ETDEWEB)

    Fachin, S.; Parrinello, C. (New York Univ., NY (United States). Physics Dept.)

    1992-05-01

    We discuss a global gauge-fixing prescription that is free of the Gribov problem, preserves reflection positivity and contains as a limiting case the (maximal) Coulomb gauge. In such a formalism it is very easy to check that only color singlet states propagate in Euclidean time, for any value of [beta]. (orig.).

  15. Are ghosts necessary in planar gauges?

    International Nuclear Information System (INIS)

    Kummer, W.

    1988-01-01

    The introduction of Faddeev-Popov ghosts in axial gauges and especially in the ones of the planar type is not a technical necessity for the general proof of renormalization and gauge independence. It is shown that all necessary identities for Green's functions and for one-particle-irreducible vertices arise in a completely ghost-free formulation as well

  16. Nonlocal hidden variables and nonlocal gauge theories

    International Nuclear Information System (INIS)

    Boiteux, M.

    1984-01-01

    A possible unification of classical fundamental interactions together with quantum interactions is proposed, based on an extension of the concept of local gauge invariance to a nonlocal gauge invariance. As an example this new concept is developed for the particular case of the electromagnetic field. (Auth.)

  17. Family gauge symmetry from a composite model

    International Nuclear Information System (INIS)

    Zhou, B.R.; Chang, C.H.; Princeton Univ., NJ

    1983-01-01

    A family gauge symmetry SUsup(F)(2) could emerge from a composite model of quarks and leptons under some assumptions of chiral hyperflavor symmetry-breaking pattern. Possible dynamical mechanisms which break the family and electroweak gauge group and produce quark-lepton masses are indicated and their phenomenologies are discussed qualitatively. (orig.)

  18. Unified gauge theories with spontaneous symmetry breaking

    International Nuclear Information System (INIS)

    MacDowell, S.W.

    1975-01-01

    Unified gauge theories with spontaneous symmetry breaking are studied with a view to renormalize quantum field theory. Georgi-Glashow and Weinberg-Salam models to unify weak and electromagnetic interactions are discussed in detail. Gauge theories of strong interactions are also considered [pt

  19. On the gauge dependence of spontaneous symmetry breaking in gauge theories

    International Nuclear Information System (INIS)

    Nielsen, N.K.

    1975-01-01

    The Ward-Takahashi identities for scalar electrodynamics in Fermi gauges are shown to imply a homogeneous first-order partial differential equation for the effective potential involving only the gauge parameter and the external scalar field. Spontaneous symmetry breaking is consequently a gauge-invariant phenomenon. Also observable quantities, including masses, physical coupling constants, and S-matrix elements, of a theory with spontaneous symmetry breaking are found to be invariant, if a change in the gauge parameter is accompanied by a suitable change in the ground-state expectation value of the scalar field. The generalization to a non-Abelian gauge theory is briefly indicated. (Auth.)

  20. Weyl gravity as a gauge theory

    Science.gov (United States)

    Trujillo, Juan Teancum

    In 1920, Rudolf Bach proposed an action based on the square of the Weyl tensor or CabcdCabcd where the Weyl tensor is an invariant under a scaling of the metric. A variation of the metric leads to the field equation known as the Bach equation. In this dissertation, the same action is analyzed, but as a conformal gauge theory. It is shown that this action is a result of a particular gauging of this group. By treating it as a gauge theory, it is natural to vary all of the gauge fields independently, rather than performing the usual fourth-order metric variation only. We show that solutions of the resulting vacuum field equations are all solutions to the vacuum Einstein equation, up to a conformal factor---a result consistent with local scale freedom. We also show how solutions for the gauge fields imply there is no gravitational self energy.

  1. Convexity, gauge-dependence and tunneling rates

    Energy Technology Data Exchange (ETDEWEB)

    Plascencia, Alexis D.; Tamarit, Carlos [Institute for Particle Physics Phenomenology, Durham University,South Road, DH1 3LE (United Kingdom)

    2016-10-19

    We clarify issues of convexity, gauge-dependence and radiative corrections in relation to tunneling rates. Despite the gauge dependence of the effective action at zero and finite temperature, it is shown that tunneling and nucleation rates remain independent of the choice of gauge-fixing. Taking as a starting point the functional that defines the transition amplitude from a false vacuum onto itself, it is shown that decay rates are exactly determined by a non-convex, false vacuum effective action evaluated at an extremum. The latter can be viewed as a generalized bounce configuration, and gauge-independence follows from the appropriate Nielsen identities. This holds for any election of gauge-fixing that leads to an invertible Faddeev-Popov matrix.

  2. Problem of changing gauge in Polyakov's theory: Relation between light-cone and conformal gauges

    International Nuclear Information System (INIS)

    Tzani, R.

    1989-01-01

    The problem of the change of gauge in string theory is discussed in the context of the functional-integral formulation of the theory. The equivalence between the light-cone and conformal gauges is shown. By performing a proper change of variables in commuting and ghost fields in the functional integral of Polykov's theory, the string theory in the conformal gauge is obtained from the light-cone gauge-fixed theory. Finally, the problem of changing gauge has been generalized to the higher-genus surfaces. It has been shown that string theory in the conformal gauge is equivalent to the light-cone gauge-fixed theory of strings, for surfaces with an arbitrary number of handles

  3. Topological Quantum Phase Transition in Synthetic Non-Abelian Gauge Potential: Gauge Invariance and Experimental Detections

    Science.gov (United States)

    Sun, Fadi; Yu, Xiao-Lu; Ye, Jinwu; Fan, Heng; Liu, Wu-Ming

    2013-01-01

    The method of synthetic gauge potentials opens up a new avenue for our understanding and discovering novel quantum states of matter. We investigate the topological quantum phase transition of Fermi gases trapped in a honeycomb lattice in the presence of a synthetic non-Abelian gauge potential. We develop a systematic fermionic effective field theory to describe a topological quantum phase transition tuned by the non-Abelian gauge potential and explore its various important experimental consequences. Numerical calculations on lattice scales are performed to compare with the results achieved by the fermionic effective field theory. Several possible experimental detection methods of topological quantum phase transition are proposed. In contrast to condensed matter experiments where only gauge invariant quantities can be measured, both gauge invariant and non-gauge invariant quantities can be measured by experimentally generating various non-Abelian gauges corresponding to the same set of Wilson loops. PMID:23846153

  4. GPM GROUND VALIDATION RAIN GAUGES NASA ACHIEVE IPHEX V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The GPM Ground Validation Rain Gauges NASA ACHIEVE IPHEx dataset includes data from the OSi Optical Rain Gauge (ORG815), and a standard tipping bucket rain gauge....

  5. GPRS based real-time reporting and internet accessible sea level gauge for monitoring storm surge and tsunami

    Digital Repository Service at National Institute of Oceanography (India)

    Desai, R.G.P.; Joseph, A; Agarvadekar, Y.; Dabholkar, N.; Mehra, P.; Gouveia, A; Tengali, S.; VijayKumar, K.; Parab, A

    Development and implementation of a real-time reporting and Internet-accessible sea level gauge is described. The paper addresses the application of mobile communication technology and particularly the use of General Packet Radio Service (GPRS...

  6. Gauge field entanglement in Kitaev's honeycomb model

    Science.gov (United States)

    Dóra, Balázs; Moessner, Roderich

    2018-01-01

    A spin fractionalizes into matter and gauge fermions in Kitaev's spin liquid on the honeycomb lattice. This follows from a Jordan-Wigner mapping to fermions, allowing for the construction of a minimal entropy ground-state wave function on the cylinder. We use this to calculate the entanglement entropy by choosing several distinct partitionings. First, by partitioning an infinite cylinder into two, the -ln2 topological entanglement entropy is reconfirmed. Second, the reduced density matrix of the gauge sector on the full cylinder is obtained after tracing out the matter degrees of freedom. This allows for evaluating the gauge entanglement Hamiltonian, which contains infinitely long-range correlations along the symmetry axis of the cylinder. The matter-gauge entanglement entropy is (Ny-1 )ln2 , with Ny the circumference of the cylinder. Third, the rules for calculating the gauge sector entanglement of any partition are determined. Rather small correctly chosen gauge partitions can still account for the topological entanglement entropy in spite of long-range correlations in the gauge entanglement Hamiltonian.

  7. Electronic design of air dust concentration gauge

    International Nuclear Information System (INIS)

    Machaj, B.; Strzalkowski, J.; Krawczynska, B.

    1993-01-01

    A new version of isotope dust concentration gauge for monitoring airborne dust pollution of air employs a ready made personal computer as the control and processing unit in the gauge instead of specialized electronics. That solution of the gauge reduces the needed specialized electronics to a simple computer interface coupling the computer to the measuring head. This also reduced electronics of the measuring head itself, i.e. GM detector circuit, power supplies and electronic circuits to switch on/off driving motors. The functioning and operation of the gauge is controlled by the computer program that can be easily modified if needed. The computer program for the gauge enables automatic measurements of dust concentration. Up to fifty measuring cycles can be easily programmed for a day. The results of measurements are presented in the form of data collection, diagram of dust concentration distribution during one day, diagram of dust distribution during 30 successive days or diagram of average dust concentration distribution during a day which may be computed by combining data of the selected number of measurements. Recalibration of the gauge and checking up of the gauge are also carried out under the program control. (author). 6 refs, 9 figs

  8. Holographic gauge mediation via strongly coupled messengers

    International Nuclear Information System (INIS)

    McGuirk, Paul; Shiu, Gary; Sumitomo, Yoske

    2010-01-01

    We consider a relative of semidirect gauge mediation where the hidden sector exists at large 't Hooft coupling. Such scenarios can be difficult to describe using perturbative field theory methods but may fall into the class of holographic gauge mediation scenarios, meaning that they are amenable to the techniques of gauge/gravity duality. We use a recently found gravity solution to examine one such case, where the hidden sector is a cascading gauge theory resulting in a confinement scale not much smaller than the messenger mass. In the original construction of holographic gauge mediation, as in other examples of semidirect gauge mediation at strong coupling, the primary contributions to visible sector soft terms come from weakly coupled messenger mesons. In contrast to these examples, we describe the dual of a gauge theory where there are significant contributions from scales in which the strongly coupled messenger quarks are the effective degrees of freedom. In this regime, the visible sector gaugino mass can be calculated entirely from holography.

  9. Gauge theory of phase and scale

    OpenAIRE

    PAW\\LOWSKI, Marek

    1999-01-01

    Old Weyl's the idea of scale recalibration freedom and Infeld's and van der Waerden's (IW) ideas concerning geometrical interpretation of natural spinor phase gauge symmetry are discussed in the context of modern models of fundamental particle interactions. It is argued that (IW) gauge symmetry can be naturaly identified with the U(1) symmetry of the Weinberg-Salam model. It is also argued that there are no serious reasons to reject Weyl's gauge the...

  10. Origin of gauge invariance in string theory

    Science.gov (United States)

    Horowitz, G. T.; Strominger, A.

    1986-01-01

    A first quantization of the space-time embedding Chi exp mu and the world-sheet metric rho of the open bosonic string. The world-sheet metric rho decouples from S-matrix elements in 26 dimensions. This formulation of the theory naturally includes 26-dimensional gauge transformations. The gauge invariance of S-matrix elements is a direct consequence of the decoupling of rho. Second quantization leads to a string field Phi(Chi exp mu, rho) with a gauge-covariant equation of motion.

  11. Models and mechanisms in gauge theories

    International Nuclear Information System (INIS)

    Polyakov, A.M.

    1979-01-01

    Several pieces of information concerning the dynamics of gauge theories are presented. Gauge fields are used for the construction of QCD and QFD. In both cases the most important question is what phases are realized if the gauge group is given. Different possibilities are known: confinement, total spontaneous breakdown, partial spontaneous breakdown and their combinations. Some unknown options also are not excluded. At the moment we have some superficial understanding of the qualitative features of different phases, but we do not know under what circumstances this or that phase is realized

  12. Supersymmetric quiver gauge theories on the lattice

    International Nuclear Information System (INIS)

    Joseph, Anosh

    2013-12-01

    In this paper we detail the lattice constructions of several classes of supersymmetric quiver gauge theories in two and three Euclidean spacetime dimensions possessing exact supersymmetry at finite lattice spacing. Such constructions are obtained through the methods of topological twisting and geometric discretization of Euclidean Yang-Mills theories with eight and sixteen supercharges in two and three dimensions. We detail the lattice constructions of two-dimensional quiver gauge theories possessing four and eight supercharges and three-dimensional quiver gauge theories possessing eight supercharges.

  13. Design of control system for profile gauge

    International Nuclear Information System (INIS)

    Huang Yibin; Zhang Yu'ai

    2013-01-01

    The profile gauge can on-line get the cross section in the steel strip, so it has been widely used in hot continuous rolling production-line. The structure of profile gauge and its distributed hardware structure based on PLC and software design of its control subsystem were introduced. The method of temperature and humidity measurement was analyzed. The time response of X-ray machine control based on RS232 communication was researched. It is proved that the control system meets the requirements of the profile gauge system. (authors)

  14. Expanding the Bethe/Gauge dictionary

    Science.gov (United States)

    Bullimore, Mathew; Kim, Hee-Cheol; Lukowski, Tomasz

    2017-11-01

    We expand the Bethe/Gauge dictionary between the XXX Heisenberg spin chain and 2d N = (2, 2) supersymmetric gauge theories to include aspects of the algebraic Bethe ansatz. We construct the wave functions of off-shell Bethe states as orbifold defects in the A-twisted supersymmetric gauge theory and study their correlation functions. We also present an alternative description of off-shell Bethe states as boundary conditions in an effective N = 4 supersymmetric quantum mechanics. Finally, we interpret spin chain R-matrices as correlation functions of Janus interfaces for mass parameters in the supersymmetric quantum mechanics.

  15. Quantum Geometry and Quiver Gauge Theories

    Science.gov (United States)

    Nekrasov, Nikita; Pestun, Vasily; Shatashvili, Samson

    2018-01-01

    We study macroscopically two dimensional N}=(2,2)} supersymmetric gauge theories constructed by compactifying the quiver gauge theories with eight supercharges on a product T}d × R2_{ɛ of a d-dimensional torus and a two dimensional cigar with {Ω} -deformation. We compute the universal part of the effective twisted superpotential. In doing so we establish the correspondence between the gauge theories and the Yangian Y_{ɛ}(g_{Γ}), quantum affine algebra U^{aff_q(g_{Γ}), or the quantum elliptic algebra U^{ell}_{q,p}(g_{Γ}) associated to Kac-Moody algebra g_{Γ} for quiver Γ.

  16. Constraints on Gauge Field Production during Inflation

    DEFF Research Database (Denmark)

    Nurmi, Sami; Sloth, Martin Snoager

    2014-01-01

    In order to gain new insights into the gauge field couplings in the early universe, we consider the constraints on gauge field production during inflation imposed by requiring that their effect on the CMB anisotropies are subdominant. In particular, we calculate systematically the bispectrum...... of the primordial curvature perturbation induced by the presence of vector gauge fields during inflation. Using a model independent parametrization in terms of magnetic non-linearity parameters, we calculate for the first time the contribution to the bispectrum from the cross correlation between the inflaton...

  17. Gauge Fields as Composite Boundary Excitations

    CERN Document Server

    Ferrara, Sergio; Ferrara, Sergio; Fronsdal, Christian

    1998-01-01

    We investigate representations of the conformal group that describe "massless" particles in the interior and at the boundary of anti-de Sitter space. It turns out that massless gauge excitations in anti-de Sitter are gauge "current" operators at the boundary. Conversely, massless excitations at the boundary are topological singletons in the interior. These representations lie at the threshold of two "unitary bounds" that apply to any conformally invariant field theory. Gravity and Yang-Mills gauge symmetry in anti-De Sitter is translated to global translational symmetry and continuous R-symmetry of the boundary superconformal field theory.

  18. Electroweak Measurements with Multiple Gauge Boson Interactions

    CERN Document Server

    Sood, Alexander; The ATLAS collaboration

    2014-01-01

    These proceedings present measurements from ATLAS and CMS using proton-proton collisions with center-of-mass energies of 7 TeV and 8 TeV at the LHC that are sensitive to interactions between EW gauge bosons. Included analyses sensitive to triple gauge couplings are EW Z production, and $VV^{\\prime}$ cross sections where $V=W,Z$ and $V^{\\prime}=W,Z,γ$, while $\\gamma\\gamma \\rightarrow WW$, $WV\\gamma$ where $V=W,Z$, and $W^{\\pm}W^{\\pm}jj$ production are presented as probes of quartic gauge couplings.

  19. Group theory and lattice gauge fields

    International Nuclear Information System (INIS)

    Creutz, M.

    1988-09-01

    Lattice gauge theory, formulated in terms of invariant integrals over group elements on lattice bonds, benefits from many group theoretical notions. Gauge invariance provides an enormous symmetry and powerful constraints on expectation values. Strong coupling expansions require invariant integrals over polynomials in group elements, all of which can be evaluated by symmetry considerations. Numerical simulations involve random walks over the group. These walks automatically generate the invariant group measure, avoiding explicit parameterization. A recently proposed overrelaxation algorithm is particularly efficient at exploring the group manifold. These and other applications of group theory to lattice gauge fields are reviewed in this talk. 17 refs

  20. Gauge copies in the Landau-DeWitt gauge: A background invariant restriction

    Science.gov (United States)

    Dudal, David; Vercauteren, David

    2018-04-01

    The Landau background gauge, also known as the Landau-DeWitt gauge, has found renewed interest during the past decade given its usefulness in accessing the confinement-deconfinement transition via the vacuum expectation value of the Polyakov loop, describable via an appropriate background. In this Letter, we revisit this gauge from the viewpoint of it displaying gauge (Gribov) copies. We generalize the Gribov-Zwanziger effective action in a BRST and background invariant way; this action leads to a restriction on the allowed gauge fluctuations, thereby eliminating the infinitesimal background gauge copies. The explicit background invariance of our action is in contrast with earlier attempts to write down and use an effective Gribov-Zwanziger action. It allows to address certain subtleties arising in these earlier works, such as a spontaneous and thus spurious Lorentz symmetry breaking, something which is now averted.

  1. Intraoperative iatrogenic peripheral retinal break in 23-gauge transconjunctival sutureless vitrectomy versus 20-gauge conventional vitrectomy.

    Science.gov (United States)

    Cha, Dong Min; Woo, Se Joon; Park, Kyu Hyung; Chung, Hum

    2013-06-01

    To compare the incidence of intraoperative iatrogenic peripheral retinal breaks (IPRBs) during 23-gauge transconjunctival sutureless vitrectomy (TSV) and conventional 20-gauge vitrectomy for various indications. This was a single-center, comparative, retrospective, interventional case series of 973 23-gauge TSVs and 402 conventional 20-gauge vitrectomies done by two surgeons between January 2004 and December 2009. The incidence rate of intraoperative IPRBs and risk factors were analyzed in association with various clinical and surgical factors. IPRBs occurred significantly less often during 23-gauge TSV (16 of 973 cases, 1.6 %) than during conventional vitrectomy (25 of 402 cases, 6.2 %, Pgauge TSV procedure with the trocar system has a lower incidence of intraoperative IPRBs than conventional 20-gauge vitrectomy. Longer operation time and induction of PVD are also independent risk factors of the complication.

  2. Gauge/string duality in confining theories

    International Nuclear Information System (INIS)

    Edelstein, J.D.; Portugues, R.

    2006-01-01

    This is the content of a set of lectures given at the ''XIII Jorge Andre Swieca Summer School on Particles and Fields'', Campos do Jordao, Brazil in January 2005. They intend to be a basic introduction to the topic of gauge/gravity duality in confining theories. We start by reviewing some key aspects of the low energy physics of non-Abelian gauge theories. Then, we present the basics of the AdS/CFT correspondence and its extension both to gauge theories in different spacetime dimensions with sixteen supercharges and to more realistic situations with less supersymmetry. We discuss the different options of interest: placing D-branes at singularities and wrapping D-branes in calibrated cycles of special holonomy manifolds. We finally present an outline of a number of non-perturbative phenomena in non-Abelian gauge theories as seen from supergravity. (Abstract Copyright [2006], Wiley Periodicals, Inc.)

  3. Constraints on gauge field production during inflation

    International Nuclear Information System (INIS)

    Nurmi, Sami; 3-Origins, Centre for Cosmology and Particle Physics Phenomenology, University of Southern Denmark, Campusvej 55, 5230 Odense M (Denmark))" data-affiliation=" (CP3-Origins, Centre for Cosmology and Particle Physics Phenomenology, University of Southern Denmark, Campusvej 55, 5230 Odense M (Denmark))" >Sloth, Martin S.

    2014-01-01

    In order to gain new insights into the gauge field couplings in the early universe, we consider the constraints on gauge field production during inflation imposed by requiring that their effect on the CMB anisotropies are subdominant. In particular, we calculate systematically the bispectrum of the primordial curvature perturbation induced by the presence of vector gauge fields during inflation. Using a model independent parametrization in terms of magnetic non-linearity parameters, we calculate for the first time the contribution to the bispectrum from the cross correlation between the inflaton and the magnetic field defined by the gauge field. We then demonstrate that in a very general class of models, the bispectrum induced by the cross correlation between the inflaton and the magnetic field can be dominating compared with the non-Gaussianity induced by magnetic fields when the cross correlation between the magnetic field and the inflaton is ignored

  4. Toward a gauge field theory of gravity.

    Science.gov (United States)

    Yilmaz, H.

    Joint use of two differential identities (Bianchi and Freud) permits a gauge field theory of gravity in which the gravitational energy is localizable. The theory is compatible with quantum mechanics and is experimentally viable.

  5. Muon number nonconservation in gauge theories

    International Nuclear Information System (INIS)

    Cheng, T.P.; Li, L.F.

    1977-01-01

    The question of separate conservation of muon and electron number is considered in the context of unified gauge theories of weak and electromagnetic interactions. Theories with heavy neutral leptons, Higgs scalars, and doubly charged heavy leptons are discussed. 28 references

  6. The gauge principle vs. the equivalence principle

    International Nuclear Information System (INIS)

    Gates, S.J. Jr.

    1984-01-01

    Within the context of field theory, it is argued that the role of the equivalence principle may be replaced by the principle of gauge invariance to provide a logical framework for theories of gravitation

  7. Gauge/string duality and hadronic physics

    OpenAIRE

    Boschi-Filho, Henrique; Braga, Nelson R. F.

    2006-01-01

    We review some recent results on phenomenological approaches to strong interactions inspired in gauge/string duality. In particular, we discuss how such models lead to very good estimates for hadronic masses.

  8. Pyrolytic graphite gauge for measuring heat flux

    Science.gov (United States)

    Bunker, Robert C. (Inventor); Ewing, Mark E. (Inventor); Shipley, John L. (Inventor)

    2002-01-01

    A gauge for measuring heat flux, especially heat flux encountered in a high temperature environment, is provided. The gauge includes at least one thermocouple and an anisotropic pyrolytic graphite body that covers at least part of, and optionally encases the thermocouple. Heat flux is incident on the anisotropic pyrolytic graphite body by arranging the gauge so that the gauge surface on which convective and radiative fluxes are incident is perpendicular to the basal planes of the pyrolytic graphite. The conductivity of the pyrolytic graphite permits energy, transferred into the pyrolytic graphite body in the form of heat flux on the incident (or facing) surface, to be quickly distributed through the entire pyrolytic graphite body, resulting in small substantially instantaneous temperature gradients. Temperature changes to the body can thereby be measured by the thermocouple, and reduced to quantify the heat flux incident to the body.

  9. Strong gauge boson scattering at the LHC

    CERN Document Server

    Rindani, S.D.

    2009-01-01

    In the standard model with electroweak symmetry breaking through the Higgs mechanism, electroweak gauge-boson scattering amplitudes are large if the Higgs boson is heavy, and electroweak gauge interactions become strong. In theories with electroweak symmetry breaking through alternative mechanisms, there could be a strongly interacting gauge sector, possibly with resonances in an accessible energy region. In general, the scattering of longitudinally polarized massive gauge bosons can give information on the mechanism of spontaneous symmetry breaking. At energies below the symmetry breaking scale, the equivalence theorem relates the scattering amplitudes to those of the "would-be" Goldstone modes. In the absence of Higgs bosons, unitarity would be restored by some new physics which can be studied through WW scattering. Some representatives models are discussed. Isolating WW scattering at a hadron collider from other contributions involving W emission from parton lines needs a good understanding of the backgrou...

  10. Analytic stochastic regularization in fermionic gauge theories

    International Nuclear Information System (INIS)

    Abdalla, E.; Viana, R.L.

    1987-11-01

    We analyse the influence of the Analytic Stochastic Regularization method in gauge symmetry, evaluating the 1-loop photon propagator correction for spinor QED. Consequences in the non-abelian case are discussed. (author) [pt

  11. Gauge/string duality in confining theories

    Energy Technology Data Exchange (ETDEWEB)

    Edelstein, J.D. [Departamento de Fi sica de Particulas, Universidade de Santiago de Compostela and Instituto Galego de Fisica de Altas Enerxias (IGFAE), 15782 Santiago de Compostela (Spain); Instituto de Fisica de La Plata (IFLP), Universidad Nacional de La Plata, La Plata (Argentina); Centro de Estudios Cientificos (CECS), Casilla 1469, Valdivia (Chile); Portugues, R. [Centro de Estudios Cientificos (CECS), Casilla 1469, Valdivia (Chile)

    2006-07-03

    This is the content of a set of lectures given at the ''XIII Jorge Andre Swieca Summer School on Particles and Fields'', Campos do Jordao, Brazil in January 2005. They intend to be a basic introduction to the topic of gauge/gravity duality in confining theories. We start by reviewing some key aspects of the low energy physics of non-Abelian gauge theories. Then, we present the basics of the AdS/CFT correspondence and its extension both to gauge theories in different spacetime dimensions with sixteen supercharges and to more realistic situations with less supersymmetry. We discuss the different options of interest: placing D-branes at singularities and wrapping D-branes in calibrated cycles of special holonomy manifolds. We finally present an outline of a number of non-perturbative phenomena in non-Abelian gauge theories as seen from supergravity. (Abstract Copyright [2006], Wiley Periodicals, Inc.)

  12. Gravitation as Gauge theory of Poincare Group

    International Nuclear Information System (INIS)

    Stedile, E.

    1982-08-01

    The geometrical approach to gauge theories, based on fiber-bundles, is shown in detail. Several gauge formalisms for gravitation are examined. In particular, it is shown how to build gauge theories for non-semisimple groups. A gravitational theory for the Poincare group, with all the essential characteristics of a Yang-Mills theory is proposed. Inonu-Wigner contractions of gauge theories are introduced, which provide a Lagrangian formalism, equivalent to a Lagrangian de Sitter theory supplemented by weak constraints. Yang and Einstein theories for gravitation become particular cases of a Yang-Mills theory. The classical limit of the proposed formalism leads to the Poisson equation, for the static case. (Author) [pt

  13. Quantum Critical Behaviour of Semisimple Gauge Theories

    DEFF Research Database (Denmark)

    Kamuk Esbensen, Jacob; Ryttov, Thomas A.; Sannino, Francesco

    2016-01-01

    We study the perturbative phase diagram of semi-simple fermionic gauge theories resembling the Standard Model. We investigate an $SU(N)$ gauge theory with $M$ Dirac flavors where we gauge first an $SU(M)_L$ and then an $SU(2)_L \\subset SU(M)_L$ of the original global symmetry $SU(M)_L\\times SU......(M)_R \\times U(1) $ of the theory. To avoid gauge anomalies we add lepton-like particles. At the two-loops level an intriguing phase diagram appears. We uncover phases in which one, two or three fixed points exist and discuss the associated flows of the coupling constants. We discover a phase featuring...

  14. Gauge invariance and Weyl-polymer quantization

    CERN Document Server

    Strocchi, Franco

    2016-01-01

    The book gives an introduction to Weyl non-regular quantization suitable for the description of physically interesting quantum systems, where the traditional Dirac-Heisenberg quantization is not applicable.  The latter implicitly assumes that the canonical variables describe observables, entailing necessarily the regularity of their exponentials (Weyl operators). However, in physically interesting cases -- typically in the presence of a gauge symmetry -- non-observable canonical variables are introduced for the description of the states, namely of the relevant representations of the observable algebra. In general, a gauge invariant ground state defines a non-regular representation of the gauge dependent Weyl operators, providing a mathematically consistent treatment of familiar quantum systems -- such as the electron in a periodic potential (Bloch electron), the Quantum Hall electron, or the quantum particle on a circle -- where the gauge transformations are, respectively, the lattice translations, the magne...

  15. Development of unified gauge theories: retrospect

    International Nuclear Information System (INIS)

    Lee, B.W.

    1977-01-01

    The construction and development of unified gauge theory of weak, electromagnetic, and strong interactions is reviewed. The Weinberg and Lee contributions to this study are mainly considered as personal recollections

  16. Algebraic formulation of higher gauge theory

    Science.gov (United States)

    Zucchini, Roberto

    2017-06-01

    In this paper, we present a purely algebraic formulation of higher gauge theory and gauged sigma models based on the abstract theory of graded commutative algebras and their morphisms. The formulation incorporates naturally Becchi - Rouet -Stora - Tyutin (BRST) symmetry and is also suitable for Alexandrov - Kontsevich - Schwartz-Zaboronsky (AKSZ) type constructions. It is also shown that for a full-fledged Batalin-Vilkovisky formulation including ghost degrees of freedom, higher gauge and gauged sigma model fields must be viewed as internal smooth functions on the shifted tangent bundle of a space-time manifold valued in a shifted L∞-algebroid encoding symmetry. The relationship to other formulations where the L∞-algebroid arises from a higher Lie groupoid by Lie differentiation is highlighted.

  17. Radiation protection programme for nuclear gauges

    International Nuclear Information System (INIS)

    Muzongomerwa, A.

    2014-04-01

    Ionizing radiation including the use of nuclear gauges can be very hazardous to humans and steps must be taken to minimize the risks so as to prevent deterministic effects and limiting chances for stochastic effects. The availability of a Radiation Protection Programme and its effective implementation ensures appropriate safety and security provisions for sealed radiation sources and promotes a safety culture within a facility that utilizes these sources. This study aims at establishing a guide on the radiation protection programme in nuclear gauges that comply with national requirements derived from current international recommendations. Elements that form part of a radiation protection programme are covered in detail as well as recommendations. The overall objective is to protect people (operators and the public) and the environment from the harmful effects of these sources if they are not properly controlled. Nuclear gauges for well logging and X-ray based gauges are outside the scope of this study. (au)

  18. Gauge covariances and nonlinear optical responses

    Science.gov (United States)

    Ventura, G. B.; Passos, D. J.; Lopes dos Santos, J. M. B.; Viana Parente Lopes, J. M.; Peres, N. M. R.

    2017-07-01

    The formalism of the reduced density matrix is pursued in both length and velocity gauges of the perturbation to the crystal Hamiltonian. The covariant derivative is introduced as a convenient representation of the position operator. This allow us to write compact expressions for the reduced density matrix in any order of the perturbation which simplifies the calculations of nonlinear optical responses; as an example, we compute the first- and third-order contributions of the monolayer graphene. Expressions obtained in both gauges share the same formal structure, allowing a comparison of the effects of truncation to a finite set of bands. This truncation breaks the equivalence between the two approaches: its proper implementation can be done directly in the expressions derived in the length gauge, but requires a revision of the equations of motion of the reduced density matrix in the velocity gauge.

  19. The gauge invariance of macroscopic electrodynamics

    International Nuclear Information System (INIS)

    Kapuscik, E.

    1984-01-01

    It is shown that the group of gauge transformations in electrodynamics is larger than that described in textbooks and literature. The proof rests on new representation of electromagnetic fields in terms of potentials. (author)

  20. Monopoles, Abelian projection, and gauge invariance

    International Nuclear Information System (INIS)

    Bonati, Claudio; Di Giacomo, Adriano; Lepori, Luca; Pucci, Fabrizio

    2010-01-01

    A direct connection is proved between the non-Abelian Bianchi Identities (NABI's) and the Abelian Bianchi identities for the 't Hooft tensor. As a consequence, the existence of a nonzero magnetic current is related to the violation of the NABI's and is a gauge-invariant property. The construction allows us to show that not all Abelian projections can be used to expose monopoles in lattice configurations: each field configuration with nonzero magnetic charge identifies its natural projection, up to gauge transformations which tend to unity at large distances. It is shown that the so-called maximal-Abelian gauge is a legitimate choice. It is also proven, starting from the NABI, that monopole condensation is a physical gauge-invariant phenomenon, independent of the choice of the Abelian projection.

  1. Gauge Theories on the Light-Front

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, Stanley J.

    2003-02-11

    The light-front quantization of gauge theories in light-cone gauge provides a frame-independent wave function representation of relativistic bound states, simple forms for current matrix elements, explicit unitary, and a trivial vacuum. The light-front Hamiltonian form of QCD provides an alternative to lattice gauge theory for the computation of nonperturbative quantities such as the hadronic spectrum and the corresponding eigenfunctions. In the case of the electroweak theory, spontaneous symmetry breaking is represented by the appearance of zero modes of the Higgs field. Light-front quantization then leads to an elegant ghost-free theory of massive gauge particles, automatically incorporating the Lorentz and 't Hooft conditions, as well as the Goldstone boson equivalence theorem.

  2. Higher spin gauge theories in any dimension

    International Nuclear Information System (INIS)

    Vasiliev, M.A.

    2004-01-01

    Some general properties of higher spin (HS) gauge theories are summarized, with the emphasize on the nonlinear theories in any dimension. The main conclusion is that nonlinear HS theories exist in any dimension. Note that HS gauge symmetries in the nonlinear HS theory differ from the Yang-Mills gauging of the global HS symmetry of a free theory one starts with by HS field strength dependent nonlinear corrections resulting from the partial gauge fixing of spontaneously broken HS symmetries in the extended non-commutative space. The HS geometry is that of the fuzzy hyperboloid in the auxiliary (fiber) non-commutative space. Its radius depends on the Weyl 0-forms which take values in the infinitive-dimensional module dual to the space of single-particle states in the system

  3. Phil Anderson and Gauge Symmetry Breaking

    Science.gov (United States)

    Witten, Edward

    In this article, I describe the celebrated paper that Phil Anderson wrote in 1962 with early contributions to the idea of gauge symmetry breaking in particle physics. To set the stage, I describe the work of Julian Schwinger to which Anderson was responding, and also some of Anderson's own work on superconductivity that provided part of the context. After describing Anderson's work I describe the later work of others, leading to the modern understanding of gauge symmetry breaking in weak interactions...

  4. Gauge choice in Witten's energy expression

    International Nuclear Information System (INIS)

    Parker, T.H.

    1985-01-01

    Witten's equation Dpsi=0 can be interpreted as a gauge fixing condition for classical supergravity. We rigorously prove the existence of asymptotically constant solutions of the more general gauge condition Dpsi=Apsi for almost all endomorphisms A of the spin bundle. Each gives an expression for the gravitational energy similar to Witten's. These include the choice A=√R, which yields the particularly elegant energy expression first noticed by Deser. (orig.)

  5. Semiconductor Laser Tracking Frequency Distance Gauge

    Science.gov (United States)

    Phillips, James D.; Reasenberg, Robert D.

    2009-01-01

    Advanced astronomical missions with greatly enhanced resolution and physics missions of unprecedented accuracy will require a spaceworthy laser distance gauge of substantially improved performance. The Tracking Frequency Gauge (TFG) uses a single beam, locking a laser to the measurement interferometer. We have demonstrated this technique with pm (10(exp -12) m) performance. We report on the version we are now developing based on space-qualifiable, fiber-coupled distributed-feedback semiconductor lasers.

  6. Gauge Theory on a Quantum Phase Space

    CERN Document Server

    Alvarez-Gaumé, Luís; Alvarez-Gaume, Luis; Wadia, Spenta R.

    2001-01-01

    In this note we present a operator formulation of gauge theories in a quantum phase space which is specified by a operator algebra. For simplicity we work with the Heisenberg algebra. We introduce the notion of the derivative (transport) and Wilson line (parallel transport) which enables us to construct a gauge theory in a simple way. We illustrate the formulation by a discussion of the Higgs mechanism and comment on the large N masterfield.

  7. Gauge structures induced on curved manifolds

    International Nuclear Information System (INIS)

    Fujii, K.; Chepilko, N.M.

    1997-01-01

    The purpose of the present talk are i) to summarize the features of the induced gauge structure appearing in CPA to one-particle motion on M n embedded in R p with p ≥n+2, ii) to show concretely the relation of the induced gauge field in CPA with that generated on S p-1 [is implied by R p ], and iii) ti give some remarks on some extension as well as possible applications

  8. Parity Violation by a Dark Gauge Boson

    CERN Document Server

    Lee, Hye-Sung

    2014-01-01

    We overview the dark parity violation, which means the parity violation induced by a dark gauge boson of very small mass and coupling. When a dark gauge boson has an axial coupling, as in dark Z model, it can change the effective Weinberg angle in the low-energy experiments such as the atomic parity violation and the low-Q^2 polarized electron scatterings. Such low-energy parity tests are an excellent probe of the dark force.

  9. Quantum communication, reference frames, and gauge theory

    International Nuclear Information System (INIS)

    Enk, S. J. van

    2006-01-01

    We consider quantum communication in the case that the communicating parties not only do not share a reference frame but use imperfect quantum communication channels, in that each channel applies some fixed but unknown unitary rotation to each qubit. We discuss similarities and differences between reference frames within that quantum communication model and gauge fields in gauge theory. We generalize the concept of refbits and analyze various quantum communication protocols within the communication model

  10. Gauge field theories: various mathematical approaches

    OpenAIRE

    Jordan, François; Serge, Lazzarini; Thierry, Masson

    2014-01-01

    This paper presents relevant modern mathematical formulations for (classical) gauge field theories, namely, ordinary differential geometry, noncommutative geometry, and transitive Lie algebroids. They provide rigorous frameworks to describe Yang-Mills-Higgs theories or gravitation theories, and each of them improves the paradigm of gauge field theories. A brief comparison between them is carried out, essentially due to the various notions of connection. However they reveal a compelling common...

  11. Gauged supergravities in various spacetime dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Weidner, M.

    2006-12-15

    In this thesis we study the gaugings of extended supergravity theories in various space-time dimensions. These theories describe the low-energy limit of non-trivial string compactifications. For each theory under consideration we work out all possible gaugings that are compatible with supersymmetry. They are parameterized by the so-called embedding tensor which is a group theoretical object that has to satisfy certain representation constraints. This embedding tensor determines all couplings in the gauged theory that are necessary to preserve gauge invariance and supersymmetry. The concept of the embedding tensor and the general structure of the gauged supergravities are explained in detail. The methods are then applied to the half-maximal (N=4) supergravities in d=4 and d=5 and to the maximal supergravities in d=2 and d=7. Examples of particular gaugings are given. Whenever possible, the higher-dimensional origin of these theories is identified and it is shown how the compactification parameters like fluxes and torsion are contained in the embedding tensor. (orig.)

  12. New gaugings and non-geometry

    International Nuclear Information System (INIS)

    Lee, Kanghoon; Strickland-Constable, Charles; Waldram, Daniel

    2017-01-01

    We discuss the possible realisation in string/M theory of the recently discovered family of four-dimensional maximal SO(8) gauged supergravities, and of an analogous family of seven-dimensional half-maximal SO(4) gauged supergravities. We first prove a no-go theorem that neither class of gaugings can be realised via a compactification that is locally described by ten- or eleven-dimensional supergravity. In the language of Double Field Theory and its M theory analogue, this implies that the section condition must be violated. Introducing the minimal number of additional coordinates possible, we then show that the standard S 3 and S 7 compactifications of ten- and eleven-dimensional supergravity admit a new class of section-violating generalised frames with a generalised Lie derivative algebra that reproduces the embedding tensor of the SO(4) and SO(8) gaugings respectively. The physical meaning, if any, of these constructions is unclear. They highlight a number of the issues that arise when attempting to apply the formalism of Double Field Theory to non-toroidal backgrounds. Using a naive brane charge quantisation to determine the periodicities of the additional coordinates restricts the SO(4) gaugings to an infinite discrete set and excludes all the SO(8) gaugings other than the standard one. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  13. New gaugings and non-geometry

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kanghoon [Quantum Universe Center, Korea Institute for Advanced Study, Seoul (Korea, Republic of); Strickland-Constable, Charles [Institut de Physique Theorique, Universite Paris Saclay, CEA, CNRS, Gif-sur-Yvette (France); Waldram, Daniel [Department of Physics, Imperial College London (United Kingdom); Berkeley Center for Theoretical Physics, University of California, Berkeley, CA (United States)

    2017-10-15

    We discuss the possible realisation in string/M theory of the recently discovered family of four-dimensional maximal SO(8) gauged supergravities, and of an analogous family of seven-dimensional half-maximal SO(4) gauged supergravities. We first prove a no-go theorem that neither class of gaugings can be realised via a compactification that is locally described by ten- or eleven-dimensional supergravity. In the language of Double Field Theory and its M theory analogue, this implies that the section condition must be violated. Introducing the minimal number of additional coordinates possible, we then show that the standard S{sup 3} and S{sup 7} compactifications of ten- and eleven-dimensional supergravity admit a new class of section-violating generalised frames with a generalised Lie derivative algebra that reproduces the embedding tensor of the SO(4) and SO(8) gaugings respectively. The physical meaning, if any, of these constructions is unclear. They highlight a number of the issues that arise when attempting to apply the formalism of Double Field Theory to non-toroidal backgrounds. Using a naive brane charge quantisation to determine the periodicities of the additional coordinates restricts the SO(4) gaugings to an infinite discrete set and excludes all the SO(8) gaugings other than the standard one. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  14. Gauge theory loop operators and Liouville theory

    Energy Technology Data Exchange (ETDEWEB)

    Drukker, Nadav [Humboldt Univ. Berlin (Germany). Inst. fuer Physik; Gomis, Jaume; Okuda, Takuda [Perimeter Inst. for Theoretical Physics, Waterloo, ON (Canada); Teschner, Joerg [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2009-10-15

    We propose a correspondence between loop operators in a family of four dimensional N=2 gauge theories on S{sup 4} - including Wilson, 't Hooft and dyonic operators - and Liouville theory loop operators on a Riemann surface. This extends the beautiful relation between the partition function of these N=2 gauge theories and Liouville correlators found by Alday, Gaiotto and Tachikawa. We show that the computation of these Liouville correlators with the insertion of a Liouville loop operator reproduces Pestun's formula capturing the expectation value of a Wilson loop operator in the corresponding gauge theory. We prove that our definition of Liouville loop operators is invariant under modular transformations, which given our correspondence, implies the conjectured action of S-duality on the gauge theory loop operators. Our computations in Liouville theory make an explicit prediction for the exact expectation value of 't Hooft and dyonic loop operators in these N=2 gauge theories. The Liouville loop operators are also found to admit a simple geometric interpretation within quantum Teichmueller theory as the quantum operators representing the length of geodesics. We study the algebra of Liouville loop operators and show that it gives evidence for our proposal as well as providing definite predictions for the operator product expansion of loop operators in gauge theory. (orig.)

  15. Compactification of gauge theories and the gauge invariance of massive modes

    Energy Technology Data Exchange (ETDEWEB)

    Amorim, R.; Barcelos-Neto, J. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Inst. de Fisica

    2002-03-01

    We study the gauge invariance of the massive modes in the compactification of gauge theories from D = 5 to D = 4. We deal with Abelian gauge theories of rank one and two, and with non-Abelian ones of rank one. We show that Stueckelberg fields naturally appear in the compactification mechanism, contrarily to what usually occurs in literature where they are introduced by hand, as a trick, to render gauge invariance for massive theories. We also show that in the non-Abelian case they appear in a very different way when compared with their usual implementation in the non-Abelian Proca model. (author)

  16. Comparing the Rξ gauge and the unitary gauge for the standard model: An example

    Directory of Open Access Journals (Sweden)

    Tai Tsun Wu

    2017-01-01

    Full Text Available For gauge theory, the matrix element for any physical process is independent of the gauge used. However, since this is a formal statement, it does not guarantee this gauge independence in every case. An example is given here where, for a physical process in the standard model, the matrix elements calculated with two different gauge – the Rξ gauge and the unitary gauge – are explicitly verified to be different. This is accomplished by subtracting one matrix element from the other. This non-zero difference turns out to have a subtle origin. Two simple operators are found not to commute with each other: in one gauge these two operations are carried out in one order, while in the other gauge these same two operations are carried out in the opposite order. Because of this result, a series of question are raised such that the answers to these question may lead to a deeper understanding of the Yang–Mills non-Abelian gauge theory in general and the standard model in particular.

  17. Transgenic rabbits that overexpress the neonatal Fc receptor (FcRn generate higher quantities and improved qualities of anti-thymocyte globulin (ATG.

    Directory of Open Access Journals (Sweden)

    Mária Baranyi

    Full Text Available Immune suppression with rabbit anti-thymocyte globulin (rATG is a well-established therapeutic concept for preventing host rejection of transplanted organs and graft versus host disease. Increasing the efficiency of rATG production by reducing the number of animals would be highly beneficial to lower cost and to improve quality standards. We have developed transgenic (Tg mice and rabbits that overexpress the neonatal Fc receptor (FcRn and have shown an augmented humoral immune response in these animals. To test whether our FcRn Tg rabbits produced rATG more efficiently, we immunized them and their New Zealand White controls with live Jurkat cells. By day 21 after immunization, Tg animals produced significantly, 1.5 times higher amount of total IgG compared to their wt littermates. Also, the binding efficiency of Tg sera to Jurkat cells and their complement-mediated cytotoxicity was significantly higher. The purified Tg IgG preparation contained 2.6 the amount of Jurkat specific IgG as the wt preparation analyzed by complement-mediated lysis, suggesting greater antigen-specific B cell activation in the Tg rabbits. To test this hypothesis, immunization with ovalbumin and human α1-antitrypsin was performed, resulting in significantly greater numbers of antigen-specific B-cells in the FcRn Tg rabbits as compared with wt controls. The shift towards significantly larger populations of antigen-specific B cells relative to the non-specific B cell pool is further corroborated by our previous findings in FcRn Tg mice. Consequently, our FcRn Tg rabbits have the potential to offer substantial qualitative and quantitative improvements for the production of rATG and other polyclonal or monoclonal antibodies.

  18. 27 CFR 19.454 - Gauge for denaturation.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Gauge for denaturation. 19... Denaturation § 19.454 Gauge for denaturation. The proprietor shall gauge spirits before denaturation and after denaturation and record each gauge on the record of denaturation as prescribed in § 19.752(b). However, spirits...

  19. 27 CFR 19.517 - Gauge for tax determination.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Gauge for tax... on Determination and Payment of Tax § 19.517 Gauge for tax determination. (a) Packages. When spirits... individual package gauge, each package shall be gauged unless the tax is to be determined on the production...

  20. 46 CFR 154.1315 - Restricted gauge excess flow valve.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Restricted gauge excess flow valve. 154.1315 Section 154... Equipment Instrumentation § 154.1315 Restricted gauge excess flow valve. Each restricted gauge that penetrates a cargo tank must have an excess flow valve unless the gauge meets § 154.536. ...

  1. 27 CFR 19.769 - Package gauge record.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Package gauge record. 19... Package gauge record. When required by this part and Part 28, a record shall be prepared to document the gauge of packages of spirits and to convey information on package gauges. The following information...

  2. 27 CFR 26.302 - Gauge and certification.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Gauge and certification... Custody to Internal Revenue Bond § 26.302 Gauge and certification. (a) Gauge. If Virgin Islands spirits to... gauged by an insular gauger at the time of their withdrawal from an insular bonded warehouse, as provided...

  3. 27 CFR 19.92 - When gauges are required.

    Science.gov (United States)

    2010-04-01

    ... Gauging of Spirits, Wines Or Alcoholic Flavoring Materials § 19.92 When gauges are required. (a) Initial proof. Except for a gauge required by § 19.383 or § 19.517 or in any case where the proof changes as a..., wine, or eligible flavors may be used whenever a subsequent gauge is required by this part to be made...

  4. 49 CFR 230.42 - Location of gauges.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION STEAM LOCOMOTIVE INSPECTION AND MAINTENANCE STANDARDS Boilers and Appurtenances Steam Gauges § 230.42 Location of gauges. Every boiler shall have at least one steam gauge which will correctly indicate the working pressure. The gauge shall be positioned so that it will be kept reasonably...

  5. A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity.

    Science.gov (United States)

    Qiao, Shuxi; Dennis, Michael; Song, Xiufeng; Vadysirisack, Douangsone D; Salunke, Devika; Nash, Zachary; Yang, Zhifen; Liesa, Marc; Yoshioka, Jun; Matsuzawa, Shu-Ichi; Shirihai, Orian S; Lee, Richard T; Reed, John C; Ellisen, Leif W

    2015-04-28

    Macroautophagy (autophagy) is a critical cellular stress response; however, the signal transduction pathways controlling autophagy induction in response to stress are poorly understood. Here we reveal a new mechanism of autophagy control whose deregulation disrupts mitochondrial integrity and energy homeostasis in vivo. Stress conditions including hypoxia and exercise induce reactive oxygen species (ROS) through upregulation of a protein complex involving REDD1, an mTORC1 inhibitor and the pro-oxidant protein TXNIP. Decreased ROS in cells and tissues lacking either REDD1 or TXNIP increases catalytic activity of the redox-sensitive ATG4B cysteine endopeptidase, leading to enhanced LC3B delipidation and failed autophagy. Conversely, REDD1/TXNIP complex expression is sufficient to induce ROS, suppress ATG4B activity and activate autophagy. In Redd1(-/-) mice, deregulated ATG4B activity and disabled autophagic flux cause accumulation of defective mitochondria, leading to impaired oxidative phosphorylation, muscle ATP depletion and poor exercise capacity. Thus, ROS regulation through REDD1/TXNIP is physiological rheostat controlling stress-induced autophagy.

  6. Absence of the Gribov ambiguity in a special algebraic gauge

    Directory of Open Access Journals (Sweden)

    Raval Haresh

    2016-01-01

    Full Text Available The Gribov ambiguity exists in various gauges except algebraic gauges. However in general, algebraic gauges are not Lorentz invariant, which is their fundamental flaw. Here we discuss a quadratic gauge fixing, which is Lorentz invariant. We show that nontrivial copies can not occur in this gauge. We then provide an example of spherically symmetric gauge field configuration and prove that with a proper boundary condition on the configuration, this gauge removes the ambiguity on a compact manifold S3${{\\mathbb S}^3}$.

  7. Absence of the Gribov ambiguity in a quadratic gauge

    Energy Technology Data Exchange (ETDEWEB)

    Raval, Haresh [Indian Institute of Technology, Bombay, Department of Physics, Mumbai (India)

    2016-05-15

    The Gribov ambiguity exists in various gauges. Algebraic gauges are likely to be ambiguity free. However, algebraic gauges are not Lorentz invariant, which is their fundamental flaw. In addition, they are not generally compatible with the boundary conditions on the gauge fields, which are needed to compactify the space i.e., the ambiguity continues to exist on a compact manifold. Here we discuss a quadratic gauge fixing, which is Lorentz invariant. We consider an example of a spherically symmetric gauge field configuration in which we prove that this Lorentz invariant gauge removes the ambiguity on a compact manifold S{sup 3}, when a proper boundary condition on the gauge configuration is taken into account. Thus, we provide one example where the ambiguity is absent on a compact manifold in the algebraic gauge. We also show that the BRST invariance is preserved in this gauge. (orig.)

  8. Gauss decomposition, Wakimoto realisation and gauged WZNW models

    International Nuclear Information System (INIS)

    Arfaei, H.; Mohammedi, N.

    1993-10-01

    The implications of gauging the Wess-Zumino-Novikov-Witten (WZNW) model using the Gauss decomposition of the group elements are explored. We show that, contrary to standard gauging of WZNW models, this gauging is carried out by minimally coupling the gauge fields. We find that this gauging, in the case of gauging an abelian vector subgroup, differs from the standard one by terms proportional to the field strength of the gauge fields. We prove that gauging an abelian vector subgroup does not have a nonlinear sigma model interpretation. This is because the target-space metric resulting from the integration over the gauge fields is degenerate. We demonstrate, however, that this kind of gauging has a natural interpretation in terms of Wakimoto variables. (orig.)

  9. Gauge-invariant fields and flow equations for Yang-Mills theories

    OpenAIRE

    Wetterich, C.

    2017-01-01

    We discuss the concept of gauge-invariant fields for non-abelian gauge theories. Infinitesimal fluctuations around a given gauge field can be split into physical and gauge fluctuations. Starting from some reference field the gauge-invariant fields are constructed by consecutively adding physical fluctuations. An effective action that depends on gauge-invariant fields becomes a gauge-invariant functional of arbitrary gauge fields by associating to every gauge field the corresponding gauge-inva...

  10. Schwinger mechanism in linear covariant gauges

    Science.gov (United States)

    Aguilar, A. C.; Binosi, D.; Papavassiliou, J.

    2017-02-01

    In this work we explore the applicability of a special gluon mass generating mechanism in the context of the linear covariant gauges. In particular, the implementation of the Schwinger mechanism in pure Yang-Mills theories hinges crucially on the inclusion of massless bound-state excitations in the fundamental nonperturbative vertices of the theory. The dynamical formation of such excitations is controlled by a homogeneous linear Bethe-Salpeter equation, whose nontrivial solutions have been studied only in the Landau gauge. Here, the form of this integral equation is derived for general values of the gauge-fixing parameter, under a number of simplifying assumptions that reduce the degree of technical complexity. The kernel of this equation consists of fully dressed gluon propagators, for which recent lattice data are used as input, and of three-gluon vertices dressed by a single form factor, which is modeled by means of certain physically motivated Ansätze. The gauge-dependent terms contributing to this kernel impose considerable restrictions on the infrared behavior of the vertex form factor; specifically, only infrared finite Ansätze are compatible with the existence of nontrivial solutions. When such Ansätze are employed, the numerical study of the integral equation reveals a continuity in the type of solutions as one varies the gauge-fixing parameter, indicating a smooth departure from the Landau gauge. Instead, the logarithmically divergent form factor displaying the characteristic "zero crossing," while perfectly consistent in the Landau gauge, has to undergo a dramatic qualitative transformation away from it, in order to yield acceptable solutions. The possible implications of these results are briefly discussed.

  11. General treatment of a non-linear gauge condition

    International Nuclear Information System (INIS)

    Malleville, C.

    1982-06-01

    A non linear gauge condition is presented in the frame of a non abelian gauge theory broken with the Higgs mechanism. It is shown that this condition already introduced for the standard SU(2) x U(1) model can be generalized for any gauge model with the same type of simplification, namely the suppression of any coupling of the form: massless gauge boson, massive gauge boson, unphysical Higgs [fr

  12. The use of a 20-gauge valved cannula during pars plana phacofragmentation with a 23-gauge ultrasonic fragmatome.

    Science.gov (United States)

    Kim, Jee Taek; Eom, Youngsub; Ahn, Jaemoon; Kim, Seong-Woo; Huh, Kuhl

    2014-01-01

    To evaluate the usefulness of a 20-gauge cannula to maintain a self-sealing sclerotomy wound after 23-gauge phacofragmentation. This retrospective study compared the suture rates after 23-gauge phacofragmentation when the 23-gauge cannula was temporarily replaced with a 20-gauge valved metal cannula versus when the 23-gauge fragmatome was inserted at the sclerotomy site without a cannula. Whereas a sclerotomy was sutured in all 31 eyes in the without-cannula group, only one eye of 14 in the cannula group required a sclerotomy suture (P gauge metal cannula, but fragmatome tip fracture can occur during fragmentation. Copyright 2014, SLACK Incorporated.

  13. Evaluation of 25-gauge Quincke and 24 — gauge Gertie Marx ...

    African Journals Online (AJOL)

    Objective: To compare the insertion characteristics and rate of complications between 25-gauge Quincke and 24-gauge Gertie Marx needles. Design: Prospective, randomized. Setting: University of Benin Teaching Hospital; a university-affiliated tertiary centre. Subjects: Parturients (ASA 1 and 2) scheduled for elective ...

  14. Physical meaning of gauge and super-gauge in general-relativistic field theories

    Energy Technology Data Exchange (ETDEWEB)

    Treder, H.

    1985-05-01

    The physical meaning of gauge groups in bimetrical, Riemannian, and Hermitian theories of gravitation is discussed. In Hermitian relativity, Einstein's A-invariance means a super-gauge group which characterizes the Einstein-Schroedinger equations as the only nondegenerate general-relativistic field theory.

  15. S-duality in N = 4 supersymmetric gauge theories with arbitrary gauge group

    International Nuclear Information System (INIS)

    Dorey, Nicholas; Fraser, Christophe; Hollowood, Timothy J.; Kneipp, Marco A.C.

    1996-12-01

    The Goddard, Nuyts and Olive conjecture for electric-magnetic duality in the Yang-Mills theory with an arbitrary gauge group G is extended by including a non-vanishing vacuum angle θ. This extended S-duality conjecture includes the case when the unbroken gauge group in non-Abelian and a definite prediction for the spectrum of dyons results. (author)

  16. Topologically massive gauge theories and their dual factorized gauge-invariant formulation

    International Nuclear Information System (INIS)

    Bertrand, Bruno; Govaerts, Jan

    2007-01-01

    There exists a well-known duality between the Maxwell-Chern-Simons theory and the 'self-dual' massive model in (2 + 1) dimensions. This dual description may be extended to topologically massive gauge theories (TMGT) for forms of arbitrary rank and in any dimension. This communication introduces the construction of this type of duality through a reparametrization of the 'master' theory action. The dual action thereby obtained preserves the full gauge symmetry structure of the original theory. Furthermore, the dual action is factorized into a propagating sector of massive gauge-invariant variables and a decoupled sector of gauge-variant variables defining a pure topological field theory. Combining the results obtained within the Lagrangian and Hamiltonian formulations, a completed structure for a gauge-invariant dual factorization of TMGT is thus achieved. (fast track communication)

  17. A gauge-theoretic approach to gravity.

    Science.gov (United States)

    Krasnov, Kirill

    2012-08-08

    Einstein's general relativity (GR) is a dynamical theory of the space-time metric. We describe an approach in which GR becomes an SU(2) gauge theory. We start at the linearized level and show how a gauge-theoretic Lagrangian for non-interacting massless spin two particles (gravitons) takes a much more simple and compact form than in the standard metric description. Moreover, in contrast to the GR situation, the gauge theory Lagrangian is convex. We then proceed with a formulation of the full nonlinear theory. The equivalence to the metric-based GR holds only at the level of solutions of the field equations, that is, on-shell. The gauge-theoretic approach also makes it clear that GR is not the only interacting theory of massless spin two particles, in spite of the GR uniqueness theorems available in the metric description. Thus, there is an infinite-parameter class of gravity theories all describing just two propagating polarizations of the graviton. We describe how matter can be coupled to gravity in this formulation and, in particular, how both the gravity and Yang-Mills arise as sectors of a general diffeomorphism-invariant gauge theory. We finish by outlining a possible scenario of the ultraviolet completion of quantum gravity within this approach.

  18. Entanglement entropy and nonabelian gauge symmetry

    International Nuclear Information System (INIS)

    Donnelly, William

    2014-01-01

    Entanglement entropy has proven to be an extremely useful concept in quantum field theory. Gauge theories are of particular interest, but for these systems the entanglement entropy is not clearly defined because the physical Hilbert space does not factor as a tensor product according to regions of space. Here we review a definition of entanglement entropy that applies to abelian and nonabelian lattice gauge theories. This entanglement entropy is obtained by embedding the physical Hilbert space into a product of Hilbert spaces associated to regions with boundary. The latter Hilbert spaces include degrees of freedom on the entangling surface that transform like surface charges under the gauge symmetry. These degrees of freedom are shown to contribute to the entanglement entropy, and the form of this contribution is determined by the gauge symmetry. We test our definition using the example of two-dimensional Yang–Mills theory, and find that it agrees with the thermal entropy in de Sitter space, and with the results of the Euclidean replica trick. We discuss the possible implications of this result for more complicated gauge theories, including quantum gravity. (paper)

  19. Noncommutative gauge fields coupled to noncommutative gravity

    Science.gov (United States)

    Aschieri, Paolo; Castellani, Leonardo

    2013-03-01

    We present a noncommutative (NC) version of the action for vielbein gravity coupled to gauge fields. Noncommutativity is encoded in a twisted star -product between forms, with a set of commuting background vector fields defining the (abelian) twist. A first order action for the gauge fields avoids the use of the Hodge dual. The NC action is invariant under diffeomorphisms and star -gauge transformations. The Seiberg-Witten map, adapted to our geometric setting and generalized for an arbitrary abelian twist, allows to re-express the NC action in terms of classical fields: the result is a deformed action, invariant under diffeomorphisms and usual gauge transformations. This deformed action is a particular higher derivative extension of the Einstein-Hilbert action coupled to Yang-Mills fields, and to the background vector fields defining the twist. Here noncommutativity of the original NC action dictates the precise form of this extension. We explicitly compute the first order correction in the NC parameter of the deformed action, and find that it is proportional to cubic products of the gauge field strength and to the symmetric anomaly tensor D_{IJK}.

  20. Entanglement entropy and nonabelian gauge symmetry

    Science.gov (United States)

    Donnelly, William

    2014-11-01

    Entanglement entropy has proven to be an extremely useful concept in quantum field theory. Gauge theories are of particular interest, but for these systems the entanglement entropy is not clearly defined because the physical Hilbert space does not factor as a tensor product according to regions of space. Here we review a definition of entanglement entropy that applies to abelian and nonabelian lattice gauge theories. This entanglement entropy is obtained by embedding the physical Hilbert space into a product of Hilbert spaces associated to regions with boundary. The latter Hilbert spaces include degrees of freedom on the entangling surface that transform like surface charges under the gauge symmetry. These degrees of freedom are shown to contribute to the entanglement entropy, and the form of this contribution is determined by the gauge symmetry. We test our definition using the example of two-dimensional Yang-Mills theory, and find that it agrees with the thermal entropy in de Sitter space, and with the results of the Euclidean replica trick. We discuss the possible implications of this result for more complicated gauge theories, including quantum gravity.

  1. Gauge threshold corrections for local orientifolds

    International Nuclear Information System (INIS)

    Conlon, Joseph P.; Palti, Eran

    2009-01-01

    We study gauge threshold corrections for systems of fractional branes at local orientifold singularities and compare with the general Kaplunovsky-Louis expression for locally supersymmetric N = 1 gauge theories. We focus on branes at orientifolds of the C 3 /Z 4 , C 3 /Z 6 and C 3 /Z 6 ' singularities. We provide a CFT construction of these theories and compute the threshold corrections. Gauge coupling running undergoes two phases: one phase running from the bulk winding scale to the string scale, and a second phase running from the string scale to the infrared. The first phase is associated to the contribution of N = 2 sectors to the IR β functions and the second phase to the contribution of both N = 1 and N = 2 sectors. In contrast, naive application of the Kaplunovsky-Louis formula gives single running from the bulk winding mode scale. The discrepancy is resolved through 1-loop non-universality of the holomorphic gauge couplings at the singularity, induced by a 1-loop redefinition of the twisted blow-up moduli which couple differently to different gauge nodes. We also study the physics of anomalous and non-anomalous U(1)s and give a CFT description of how masses for non-anomalous U(1)s depend on the global properties of cycles.

  2. A gauge-theoretic approach to gravity

    Science.gov (United States)

    Krasnov, Kirill

    2012-01-01

    Einstein's general relativity (GR) is a dynamical theory of the space–time metric. We describe an approach in which GR becomes an SU(2) gauge theory. We start at the linearized level and show how a gauge-theoretic Lagrangian for non-interacting massless spin two particles (gravitons) takes a much more simple and compact form than in the standard metric description. Moreover, in contrast to the GR situation, the gauge theory Lagrangian is convex. We then proceed with a formulation of the full nonlinear theory. The equivalence to the metric-based GR holds only at the level of solutions of the field equations, that is, on-shell. The gauge-theoretic approach also makes it clear that GR is not the only interacting theory of massless spin two particles, in spite of the GR uniqueness theorems available in the metric description. Thus, there is an infinite-parameter class of gravity theories all describing just two propagating polarizations of the graviton. We describe how matter can be coupled to gravity in this formulation and, in particular, how both the gravity and Yang–Mills arise as sectors of a general diffeomorphism-invariant gauge theory. We finish by outlining a possible scenario of the ultraviolet completion of quantum gravity within this approach. PMID:22792040

  3. Abelian 2-form gauge theory: special features

    International Nuclear Information System (INIS)

    Malik, R P

    2003-01-01

    It is shown that the four (3 + 1)-dimensional (4D) free Abelian 2-form gauge theory provides an example of (i) a class of field theoretical models for the Hodge theory, and (ii) a possible candidate for the quasi-topological field theory (q-TFT). Despite many striking similarities with some of the key topological features of the two (1 + 1)-dimensional (2D) free Abelian (and self-interacting non-Abelian) gauge theories, it turns out that the 4D free Abelian 2-form gauge theory is not an exact TFT. To corroborate this conclusion, some of the key issues are discussed. In particular, it is shown that the (anti-)BRST and (anti-)co-BRST invariant quantities of the 4D 2-form Abelian gauge theory obey recursion relations that are reminiscent of the exact TFTs but the Lagrangian density of this theory is not found to be able to be expressed as the sum of (anti-)BRST and (anti-)co-BRST exact quantities as is the case with the topological 2D free Abelian (and self-interacting non-Abelian) gauge theories

  4. Dynamical gauge coupling unification from moduli stabilization

    International Nuclear Information System (INIS)

    Choi, Kiwoon

    2006-01-01

    In D-brane models, different part of the 4-dimensional gauge group might originate from D-branes wrapping different cycles in the internal space, and then the standard model gauge couplings at the compactification scale are determined by different cycle-volume moduli. We point out that those cycle-volume moduli can naturally have universal vacuum expectation values up to small deviations suppressed by 1/8π 2 if they are stabilized by KKLT-type non-perturbative superpotential with properly chosen discrete parameters. This dynamical unification of gauge couplings is independent of the detailed form of the moduli Kahler potential, but relies crucially on the existence of low energy supersymmetry. If supersymmetry is broken by an uplifting brane as in KKLT compactification, again independently of the detailed form of the moduli Kahler potential, the moduli-mediated gaugino masses at the compactification scale are universal also, and are comparable to the anomaly-mediated gaugino masses. As a result, both the gauge coupling unification at high energy scale and the mirage mediation pattern of soft supersymmetry breaking masses are achieved naturally even when the different sets of the standard model gauge bosons originate from D-branes wrapping different cycles in the internal space

  5. Gauge fields and infinite chains of dualities

    Energy Technology Data Exchange (ETDEWEB)

    Boulanger, Nicolas [Service de Mécanique et Gravitation, Université de Mons - UMONS,20 place du Parc, B-7000 Mons (Belgium); Sundell, Per [Departamento de Ciencias Físicas, Universidad Andres Bello - UNAB,Av. República 252, Santiago (Chile); West, Peter [Department of Mathematics, King’s College,London WC2R 2LS (United Kingdom)

    2015-09-28

    We show that the particle states of Maxwell’s theory, in D dimensions, can be represented in an infinite number of ways by using different gauge fields. Using this result we formulate the dynamics in terms of an infinite set of duality relations which are first order in space-time derivatives. We derive a similar result for the three form in eleven dimensions where such a possibility was first observed in the context of E{sub 11}. We also give an action formulation for some of the gauge fields. In this paper we give a pedagogical account of the Lorentz and gauge covariant formulation of the irreducible representations of the Poincaré group, used previously in higher spin theories, as this plays a key role in our constructions. It is clear that our results can be generalised to any particle.

  6. Renormalization of gauge theories without cohomology

    International Nuclear Information System (INIS)

    Anselmi, Damiano

    2013-01-01

    We investigate the renormalization of gauge theories without assuming cohomological properties. We define a renormalization algorithm that preserves the Batalin-Vilkovisky master equation at each step and automatically extends the classical action till it contains sufficiently many independent parameters to reabsorb all divergences into parameter-redefinitions and canonical transformations. The construction is then generalized to the master functional and the field-covariant proper formalism for gauge theories. Our results hold in all manifestly anomaly-free gauge theories, power-counting renormalizable or not. The extension algorithm allows us to solve a quadratic problem, such as finding a sufficiently general solution of the master equation, even when it is not possible to reduce it to a linear (cohomological) problem. (orig.)

  7. Constrained gauge fields from spontaneous Lorentz violation

    DEFF Research Database (Denmark)

    Chkareuli, J. L.; Froggatt, C. D.; Jejelava, J. G.

    2008-01-01

    Spontaneous Lorentz violation realized through a nonlinear vector field constraint of the type AµAµ=M2 (M is the proposed scale for Lorentz violation) is shown to generate massless vector Goldstone bosons, gauging the starting global internal symmetries in arbitrary relativistically invariant...... theories. The gauge invariance appears in essence as a necessary condition for these bosons not to be superfluously restricted in degrees of freedom, apart from the constraint due to which the true vacuum in a theory is chosen by the Lorentz violation. In the Abelian symmetry case the only possible theory...... couplings when expressed in terms of the pure Goldstone vector modes. However, they do not lead to physical Lorentz violation due to the simultaneously generated gauge invariance. Udgivelsesdato: June 11...

  8. Light higgsino for gauge coupling unification

    Directory of Open Access Journals (Sweden)

    Kwang Sik Jeong

    2017-06-01

    Full Text Available We explore gauge coupling unification and dark matter in high scale supersymmetry where the scale of supersymmetry breaking is much above the weak scale. The gauge couplings unify as precisely as in low energy supersymmetry if the higgsinos, whose mass does not break supersymmetry, are much lighter than those obtaining masses from supersymmetry breaking. The dark matter of the universe can then be explained by the neutral higgsino or the gravitino. High scale supersymmetry with light higgsinos requires a large Higgs mixing parameter for electroweak symmetry breaking to take place. It is thus naturally realized in models where superparticle masses are generated at loop level while the Higgs mixing parameter is induced at tree level, like in anomaly and gauge mediation of supersymmetry breaking.

  9. Gauge field vacuum structure in geometrical aspect

    International Nuclear Information System (INIS)

    Konopleva, N.P.

    2003-01-01

    Vacuum conception is one of the main conceptions of quantum field theory. Its meaning in classical field theory is also very profound. In this case the vacuum conception is closely connected with ideas of the space-time geometry. The global and local geometrical space-time conceptions lead to different vacuum definitions and therefore to different ways of physical theory construction. Some aspects of the gauge field vacuum structure are analyzed. It is shown that in the gauge field theory the vacuum Einstein equation solutions describe the relativistic vacuum as common vacuum of all gauge fields and its sources. Instantons (both usual and hyperbolical) are regarded as nongravitating matter, because they have zero energy-momentum tensors and correspond to vacuum Einstein equations

  10. Gauge-invariant variables and entanglement entropy

    Science.gov (United States)

    Agarwal, Abhishek; Karabali, Dimitra; Nair, V. P.

    2017-12-01

    The entanglement entropy (EE) of gauge theories in three spacetime dimensions is analyzed using manifestly gauge-invariant variables defined directly in the continuum. Specifically, we focus on the Maxwell, Maxwell-Chern-Simons (MCS), and non-Abelian Yang-Mills theories. Special attention is paid to the analysis of edge modes and their contribution to EE. The contact term is derived without invoking the replica method and its physical origin is traced to the phase space volume measure for the edge modes. The topological contribution to the EE for the MCS case is calculated. For all the Abelian cases, the EE presented in this paper agrees with known results in the literature. The EE for the non-Abelian theory is computed in a gauge-invariant Gaussian approximation, which incorporates the dynamically generated mass gap. A formulation of the contact term for the non-Abelian case is also presented.

  11. Topological charge of (lattice) gauge fields

    International Nuclear Information System (INIS)

    Goeckeler, M.; Schierholz, G.; Wiese, U.J.

    1985-12-01

    Using recently derived explicit formulae for the 2- and 3-cochains in SU(2) gauge theory, we are able to integrate the Chern-Simons density analytically. We arrive - in SU(2) - at a local algebraic expression for the topological charge, which is the sum of local winding numbers associated with the corners (lattice points) of the cells covering the manifold plus contributions from possible isolated gauge singularities which manifest themselves as 'vortices' in the 1-, 2- or 3-cochains. Among others we consider hypercubic geometry - i.e. covering the manifold by hypercubes - which is of particular interest to lattice Monte Carlo applications. Finally, we extend our results to SU(3) gauge theory. (orig.)

  12. Light higgsino for gauge coupling unification

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kwang Sik, E-mail: ksjeong@pusan.ac.kr

    2017-06-10

    We explore gauge coupling unification and dark matter in high scale supersymmetry where the scale of supersymmetry breaking is much above the weak scale. The gauge couplings unify as precisely as in low energy supersymmetry if the higgsinos, whose mass does not break supersymmetry, are much lighter than those obtaining masses from supersymmetry breaking. The dark matter of the universe can then be explained by the neutral higgsino or the gravitino. High scale supersymmetry with light higgsinos requires a large Higgs mixing parameter for electroweak symmetry breaking to take place. It is thus naturally realized in models where superparticle masses are generated at loop level while the Higgs mixing parameter is induced at tree level, like in anomaly and gauge mediation of supersymmetry breaking.

  13. Revisiting R-invariant direct gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Chiang, Cheng-Wei [Center for Mathematics and Theoretical Physics andDepartment of Physics, National Central University,Taoyuan, Taiwan 32001, R.O.C. (China); Institute of Physics, Academia Sinica,Taipei, Taiwan 11529, R.O.C. (China); Physics Division, National Center for Theoretical Sciences,Hsinchu, Taiwan 30013, R.O.C. (China); Kavli IPMU (WPI), UTIAS, University of Tokyo,Kashiwa, Chiba 277-8583 (Japan); Harigaya, Keisuke [Department of Physics, University of California,Berkeley, California 94720 (United States); Theoretical Physics Group, Lawrence Berkeley National Laboratory,Berkeley, California 94720 (United States); ICRR, University of Tokyo,Kashiwa, Chiba 277-8582 (Japan); Ibe, Masahiro [Kavli IPMU (WPI), UTIAS, University of Tokyo,Kashiwa, Chiba 277-8583 (Japan); ICRR, University of Tokyo,Kashiwa, Chiba 277-8582 (Japan); Yanagida, Tsutomu T. [Kavli IPMU (WPI), UTIAS, University of Tokyo,Kashiwa, Chiba 277-8583 (Japan)

    2016-03-21

    We revisit a special model of gauge mediated supersymmetry breaking, the “R-invariant direct gauge mediation.” We pay particular attention to whether the model is consistent with the minimal model of the μ-term, i.e., a simple mass term of the Higgs doublets in the superpotential. Although the incompatibility is highlighted in view of the current experimental constraints on the superparticle masses and the observed Higgs boson mass, the minimal μ-term can be consistent with the R-invariant gauge mediation model via a careful choice of model parameters. We derive an upper limit on the gluino mass from the observed Higgs boson mass. We also discuss whether the model can explain the 3σ excess of the Z+jets+E{sub T}{sup miss} events reported by the ATLAS collaboration.

  14. Maximal Abelian gauge and a generalized BRST transformation

    Directory of Open Access Journals (Sweden)

    Shinichi Deguchi

    2016-05-01

    Full Text Available We apply a generalized Becchi–Rouet–Stora–Tyutin (BRST formulation to establish a connection between the gauge-fixed SU(2 Yang–Mills (YM theories formulated in the Lorenz gauge and in the Maximal Abelian (MA gauge. It is shown that the generating functional corresponding to the Faddeev–Popov (FP effective action in the MA gauge can be obtained from that in the Lorenz gauge by carrying out an appropriate finite and field-dependent BRST (FFBRST transformation. In this procedure, the FP effective action in the MA gauge is found from that in the Lorenz gauge by incorporating the contribution of non-trivial Jacobian due to the FFBRST transformation of the path integral measure. The present FFBRST formulation might be useful to see how Abelian dominance in the MA gauge is realized in the Lorenz gauge.

  15. QCD plasma parameters in axial gauge

    Energy Technology Data Exchange (ETDEWEB)

    Nachbagauer, H. (Technische Univ., Vienna (Austria). Inst. fuer Theoretische Physik)

    1992-11-01

    Within the framework of imaginary time formalism we investigate the structure of the gluon polarization tensor and relate its structure functions to the dispersion relation of plasma eigenmodes. To one loop order, we calculate the transversal structure function to leading order in the high temperature expansion as well as the first subleading order contribution in the long wavelength limit. The result is used to express the dynamical mass and the damping constant for transversal plasma eigenmodes. The aim of our present paper is a systematic discussion of the gauge fixing vector dependence of the damping constant. In the limit of temporal axial gauge we encounter a negative damping constant contradicting previous results. (orig.).

  16. QCD plasma parameters in axial gauge

    Science.gov (United States)

    Nachbagauer, Herbert

    1992-09-01

    Within the framework of imaginary time formalism we investigate the structure of the gluon polarization tensor and relate its structure functions to the dispersion relation of plasma eigenmodes. To one loop order, we calculate the transversal structure function to leading order in the high temperature expansion as well as the first subleading order contribution in the long wavelength limit. The result is used to express the dynamical mass and the damping constant for transversal plasma eigenmodes. The aim of our present paper is a systematic discussion of the gauge fixing vector dependence of the damping constant. In the limit of temporal axial gauge we encounter a negative damping constant contradicting previous results.

  17. A new 2 D bracket positioning gauge

    Directory of Open Access Journals (Sweden)

    Bhuwan Saklecha

    2017-01-01

    Full Text Available Bracket positioning is the basic premise of pre-adjusted system, which allows the teeth to be placed with a straight wire into an occlusal contact with an excellent mesiodistal inclination (tip and excellent faciolingual inclination (torque. Improper bracket placement may lead to poorly placed teeth and necessitate bracket repositioning and archwire adjustments. This can lead to an increased treatment time or poor occlusion. Therefore, a bracket positioning gauge has been designed using both the planes and evaluated for its accuracy in bonding of brackets. It was found that the gauge not only helped in the placement of brackets accurately, but also reduced chairside time.

  18. Localizing gauge theories on S d

    Science.gov (United States)

    Minahan, Joseph A.

    2016-04-01

    We conjecture the form of the one-loop determinants for localized gauge theories with eight supersymmetries on d-dimensional spheres. Combining this with results for the localized action, we investigate the strong coupling behavior in the large N limit for a continuous range of d. In particular, we find the N dependence of the free energy for supersymmetric Yang-Mills with only a vector multiplet in 3 effective way to regularize divergences after localization in d = 4 for {N}=2 gauge theories and d = 6 for the maximally supersymmetric case.

  19. Dirac gauginos, gauge mediation and unification

    Energy Technology Data Exchange (ETDEWEB)

    Benakli, K. [UPMC Univ. Paris 06 (France). Laboratoire de Physique Theorique et Hautes Energies, CNRS; Goodsell, M.D. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2010-03-15

    We investigate the building of models with Dirac gauginos and perturbative gauge coupling unification. Here, in contrast to the MSSM, additional fields are required for unification, and these can naturally play the role of the messengers of supersymmetry breaking. We present a framework within which such models can be constructed, including the constraints that the messenger sector must satisfy; and the renormalisation group equations for the soft parameters, which differ from those of the MSSM. For illustration, we provide the spectrum at the electroweak scale for explicit models whose gauge couplings unify at the scale predicted by heterotic strings. (orig.)

  20. Dirac gauginos, gauge mediation and unification

    International Nuclear Information System (INIS)

    Benakli, K.

    2010-03-01

    We investigate the building of models with Dirac gauginos and perturbative gauge coupling unification. Here, in contrast to the MSSM, additional fields are required for unification, and these can naturally play the role of the messengers of supersymmetry breaking. We present a framework within which such models can be constructed, including the constraints that the messenger sector must satisfy; and the renormalisation group equations for the soft parameters, which differ from those of the MSSM. For illustration, we provide the spectrum at the electroweak scale for explicit models whose gauge couplings unify at the scale predicted by heterotic strings. (orig.)

  1. On the stochastic quantization of gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Jona-Lasinio, G.; Parrinello, C.

    1988-11-03

    The non-gradient stochastic quantization scheme for gauge theories proposed by Zwanziger is analyzed in the semiclassical limit. Using ideas from the theory of small random perturbations of dynamical systems we derive a lower bound for the equilibrium distribution in a neighbourhood of a stable critical point of the drift. In this approach the calculation of the equilibrium distribution is reduced to the problem of finding a minimum for the large fluctuation functional associated to the Langevin equation. Our estimate follows from a simple upper bound for this minimum; in addition to the Yang-Mills action a gauge-fixing term which tends to suppress Gribov copies appears.

  2. Gauge invariant actions for string models

    International Nuclear Information System (INIS)

    Banks, T.

    1986-06-01

    String models of unified interactions are elegant sets of Feynman rules for the scattering of gravitons, gauge bosons, and a host of massive excitations. The purpose of these lectures is to describe the progress towards a nonperturbative formulation of the theory. Such a formulation should make the geometrical meaning of string theory manifest and explain the many ''miracles'' exhibited by the string Feynman rules. There are some new results on gauge invariant observables, on the cosmological constant, and on the symmetries of interacting string field theory. 49 refs

  3. Extended tree-level gauge mediation

    DEFF Research Database (Denmark)

    Monaco, M.; Nardecchia, M.; Romanino, A.

    2011-01-01

    Tree-level gauge mediation (TGM) is a scenario of SUSY breaking in which the tree-level exchange of heavy (possibly GUT) vector fields generates flavor-universal sfermion masses. In this work we extend this framework to the case of E(6) that is the natural extension of the minimal case studied so...... if the gauge group does not contain SU(5). If SUSY breaking is mediated purely by the U(1) generator that commutes with SO(10) we obtain universal sfermion masses and thus can derive the CMSSM boundary conditions in a novel scenario....

  4. Recursion equations in gauge field theories

    International Nuclear Information System (INIS)

    Migdal, A.A.

    1975-01-01

    An approximate recursive equation describing scale transformation of the effective action of a gauging field has been formulated. The equation becomes exact in the two-dimensional space-time. In the four-dimensional theory it reproduces the asymptotic freedom with an accuracy of 30% in β-function coefficients. In the region of strong coupling β-function remains negative, that leads to an asymptotic ''prison'' in the infrared range. Some possible generalizations and appendices to the colour quark-gluon gauging theory are being discussed

  5. HLA-C KIR-Ligands Determine the Impact of Anti-Thymocyte Globulin (ATG) on Graft versus Host and Graft versus Leukemia Effects Following Hematopoietic Stem Cell Transplantation.

    Science.gov (United States)

    Clausen, Johannes; Böhm, Alexandra; Straßl, Irene; Stiefel, Olga; Buxhofer-Ausch, Veronika; Machherndl-Spandl, Sigrid; König, Josef; Schmidt, Stefan; Steitzer, Hansjörg; Danzer, Martin; Kasparu, Hedwig; Weltermann, Ansgar; Nachbaur, David

    2017-03-28

    Rabbit anti-thymocyte globulins (ATGs) are widely used for the prevention of acute and chronic graft versus host disease (aGVHD, cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT). However, most prospective and retrospective studies did not reveal an overall survival (OS) benefit associated with ATG. Homozygosity for human leukocyte antigen (HLA)-C group 1 killer-cell immunoglobulin-like receptor ligands (KIR-L), i.e. C1/1 KIR-L status, was recently shown to be a risk factor for severe aGVHD. Congruously, we have previously reported favorable outcomes in C1/1 recipients after ATG-based transplants in a monocentric analysis. Here, within an extended cohort, we test the hypothesis that incorporation of ATG for GVHD prophylaxis may improve survival particularly in HSCT recipients with at least one C1 KIR-ligand. Retrospectively, 775 consecutive allogeneic (excluding haploidentical) HSCTs were analyzed, including peripheral blood and bone marrow grafts for adults with hematological diseases at two Austrian HSCT centers. ATG-Fresenius/Grafalon, Thymoglobuline, and alemtuzumab were applied in 256, 87, and 7 transplants, respectively (subsequently summarized as "ATG"), while 425 HSCT were performed without ATG. Median follow-up of surviving patients is 48 months. Adjusted for age, disease-risk, HLA-match, donor and graft type, sex match, cytomegalovirus serostatus, conditioning intensity, and type of post-grafting GVHD prophylaxis, Cox regression analysis of the entire cohort ( n = 775) revealed a significant association of ATG with decreased non-relapse mortality (NRM) (risk ratio (RR), 0.57; p = 0.001), and overall mortality (RR, 0.71; p = 0.014). Upon stratification for HLA-C KIR-L, the greatest benefit for ATG emerged in C1/1 recipients ( n = 291), by reduction of non-relapse (RR, 0.34; p = 0.0002) and overall mortality (RR, 0.50; p = 0.003). Less pronounced, ATG decreased NRM (RR, 0.60; p = 0.036) in HLA-C group 1/2 recipients ( n = 364

  6. Assessment of patient pain experience during intravitreal 27-gauge bevacizumab and 30-gauge ranibizumab injection.

    Science.gov (United States)

    Güler, Mete; Bilgin, Burak; Çapkın, Musa; Şimşek, Ali; Bilak, Şemsettin

    2015-06-01

    To compare pain scores of patients during intravitreal 27-gauge bevacizumab and 30-gauge ranibizumab injection procedures. Seventy eyes of 70 patients who had not previously undergone intravitreal anti-vascular endothelial growth factor therapy were included in this study. Thirty-five patients received ranibizumab and 35 patients received bevacizumab. The diagnoses of the patients were: 27 age related macular degeneration, 15 diabetic macular edema, 9 diabetic vitreous hemorrhage, 6 central retinal vein occlusion, 11 branch retinal vein occlusion and 2 central serous chorioretinopathy. Bevacizumab (1.25 mg/0.05 mL) was injected into the vitreous cavity using a 27-gauge needle, and ranibizumab (0.5 mg/0.05 mL) was injected with 30-gauge needle. Patients were asked just after the injection to rate their perceived pain during the injection using the visual analogue scale (VAS) of 0 (no pain) to 10 (unbearable/worst pain). The average of these scores was used as the primary outcome. The VAS pain scores in the ranibizumab and bevacizumab groups were 1.06 ± 0.91 (range, 0 to 3) and 1.94 ± 1.55 (range, 0 to 7), respectively, a significant difference (p = 0.005). Patients gauge intravitreal injection is more comfortable than 27-gauge injection. Injection of bevacizumab with 30-gauge needle syringes may be more tolerable for patients.

  7. Bloch Waves in Minimal Landau Gauge and the Infinite-Volume Limit of Lattice Gauge Theory.

    Science.gov (United States)

    Cucchieri, Attilio; Mendes, Tereza

    2017-05-12

    By exploiting the similarity between Bloch's theorem for electrons in crystalline solids and the problem of Landau gauge fixing in Yang-Mills theory on a "replicated" lattice, we show that large-volume results can be reproduced by simulations performed on much smaller lattices. This approach, proposed by Zwanziger [Nucl. Phys. B412, 657 (1994)NUPBBO0550-321310.1016/0550-3213(94)90396-4], corresponds to taking the infinite-volume limit for Landau-gauge field configurations in two steps: first for the gauge transformation alone, while keeping the lattice volume finite, and second for the gauge-field configuration itself. The solutions to the gauge-fixing condition are then given in terms of Bloch waves. Applying the method to data from Monte Carlo simulations of pure SU(2) gauge theory in two and three space-time dimensions, we are able to evaluate the Landau-gauge gluon propagator for lattices of linear extent up to 16 times larger than that of the simulated lattice. This approach is reminiscent of the Fisher-Ruelle construction of the thermodynamic limit in classical statistical mechanics.

  8. Some new applications of nucleonic gauges in Russia

    International Nuclear Information System (INIS)

    Fedorkov, V.G.

    2000-01-01

    Russia has been a big producer of nucleonic gauges for many years. There are still some institutions that design and manufacture nucleonic gauges for industry, like level gauges, density gauges and thickness gauges. Industrial demands for NCS (especially after the Chernobyl accident) have been decreasing. Examples of recent development are given in this paper. Substantial improvements in the hardware, source and detectors system, are being undertaken. The potential for new applications is large, also, there is a good capability of local researchers for increasing the quality and quantity of nucleonic gauges in industry to meet local needs and to compete better in the international scale and market. (author)

  9. The light-cone gauge in Polyakov's theory of strings and its relation to the conformal gauge

    International Nuclear Information System (INIS)

    Tzani, R.

    1989-01-01

    The author studies the string theory as a gauge theory. The analysis includes the formulation of the interacting bosonic string by fixing the Gervais-Sakita light-cone gauge in Polyakov's path-integral formulation of the theory and the study of the problem of changing gauge in string theory in the context of the functional formulation of the theory. The main results are the following: Mandelstam's picture is obtained from the light-cone gauge fixed Polyakov's theory. Due to the off-diagonal nature of the gauge, the calculation of the determinants differs from the usual (conformal gauge) case. The regularization of the functional integrals associated with these determinants is done by using the conformal-invariance principle. He then shows that the conformal anomaly associated with this new gauge fixing is canceled at dimensions of space-time d = 26. Studying the problem of changing gauge in string theory, he shows the equivalence between the light-cone and conformal gauge in the path-integral formulation of the theory. In particular, by performing a proper change of variables in the commuting and ghost fields in the Polyakov path-integral, the string theory in the conformal gauge is obtained from the light-cone gauge fixed expression. Finally, the problem of changing gauge is generalized to the higher genus surfaces. It is shown that the string theory in the conformal gauge is equivalent to the light-cone gauge fixed theory for surface with arbitrary number of handles

  10. Comparison of postoperative intraocular pressure changes between 23-gauge transconjunctival sutureless vitrectomy and conventional 20-gauge vitrectomy

    Science.gov (United States)

    Ahn, S J; Woo, S J; Ahn, J; Park, K H

    2012-01-01

    Purpose To compare the intraocular pressure (IOP) after 23-gauge transconjunctival sutureless vitrectomy (TSV) and conventional 20-gauge vitrectomy for various vitreoretinal diseases. Methods This was a retrospective interventional case series including 338 cases of 23-gauge TSV and 476 cases of 20-gauge vitrectomy with minimum follow-up period of 1 month. Postoperative 1 day, 1 week and 1 month IOPs were compared. Multiple regression analysis to assess the actual effect of gauge of vitrectomy on postoperative IOP was performed including intraoperative and postoperative factors influencing postoperative IOP as covariates. Results The mean IOP of 20-gauge vitrectomy was significantly higher than that of 23-gauge TSV (20.6±8.02 mm Hg vs12.8±4.48 mm Hg, Pgauge TSV demonstrated more stable course than that of 20-gauge vitrectomy. At 1 day post vitrectomy, the incidence of hypertony was higher in 20-gauge, whereas that of hypotony was higher in 23-gauge. Among risk factors, the 20-gauge vitrectomy showed the strongest association with postoperative 1 day IOP rise. Conclusion Twenty-three-gauge TSV has stable and lower IOP in the early postoperative period than the 20-gauge vitrectomy. In patients whose retina and optic nerves are vulnerable to higher or fluctuating IOP, 23-gauge TSV may be more beneficial. PMID:22388595

  11. Comparison of postoperative intraocular pressure changes between 23-gauge transconjunctival sutureless vitrectomy and conventional 20-gauge vitrectomy.

    Science.gov (United States)

    Ahn, S J; Woo, S J; Ahn, J; Park, K H

    2012-06-01

    To compare the intraocular pressure (IOP) after 23-gauge transconjunctival sutureless vitrectomy (TSV) and conventional 20-gauge vitrectomy for various vitreoretinal diseases. This was a retrospective interventional case series including 338 cases of 23-gauge TSV and 476 cases of 20-gauge vitrectomy with minimum follow-up period of 1 month. Postoperative 1 day, 1 week and 1 month IOPs were compared. Multiple regression analysis to assess the actual effect of gauge of vitrectomy on postoperative IOP was performed including intraoperative and postoperative factors influencing postoperative IOP as covariates. The mean IOP of 20-gauge vitrectomy was significantly higher than that of 23-gauge TSV (20.6 ± 8.02 mm Hg vs 12.8 ± 4.48 mm Hg, Pgauge TSV demonstrated more stable course than that of 20-gauge vitrectomy. At 1 day post vitrectomy, the incidence of hypertony was higher in 20-gauge, whereas that of hypotony was higher in 23-gauge. Among risk factors, the 20-gauge vitrectomy showed the strongest association with postoperative 1 day IOP rise. Twenty-three-gauge TSV has stable and lower IOP in the early postoperative period than the 20-gauge vitrectomy. In patients whose retina and optic nerves are vulnerable to higher or fluctuating IOP, 23-gauge TSV may be more beneficial.

  12. Headache after lumbar puncture: randomised crossover trial of 22-gauge versus 25-gauge needles.

    Science.gov (United States)

    Crock, Catherine; Orsini, Francesca; Lee, Katherine J; Phillips, Roderic J

    2014-03-01

    To compare the frequency of headache and the procedure time following lumbar puncture (LP) using a 25-gauge needle compared to a 22-gauge needle. 4-period crossover blinded randomised controlled trial. Oncology unit, Royal Children's Hospital, Melbourne. Children aged 4-15 years at enrolment having LPs as part of their treatment for leukaemia. Each child was allocated a random sequence of four LPs, two with a 22-gauge and two with a 25-gauge needle. The presence of post-LP headache. Secondary outcomes included the presence of any headache, procedure time and impact of headache on the family. Data on 341 procedures in 93 randomised children were analysed. There was little difference in the incidence of post-LP headache between the two needle sizes (22-gauge 7.2%, 95% CI 3.8 to 12.2; 25-gauge 4.6%, 95% CI 2.0 to 8.9, p=0.3) or in the incidence of any headache (22-gauge 18% 95% CI 12.5 to 24.6; 25-gauge 15%, 95% CI 10.0 to 21.1, p=0.4). Use of the 25-gauge needle was associated with longer procedure times. The incidence of post-LP headache showed little evidence of an age effect (OR =1.1, 95% CI 0.98 to 1.3) and was higher in girls than in boys (11% vs 3%, respectively, OR=3.3, 95% CI 1.3 to 8.4, p=0.014). Fifty-five per cent of families with a child with a post-LP headache assessed the overall functional impact as moderate or severe. There was little difference in the occurrence of post-LP headache or any headache between procedures carried out using the 22-gauge or 25-gauge needles. Depending on the circumstances of the procedure and the experience of the operator, either gauge may be appropriate for an LP in a child.

  13. Compatibility of the Radio Frequency Mass Gauge with Composite Tanks

    Science.gov (United States)

    Zimmerli, Greg; Mueller, Carl

    2015-01-01

    The radio frequency mass gauge (RFMG) is a low-gravity propellant quantity gauge being developed at NASA for possible use in long-duration space missions utilizing cryogenic propellants. As part of the RFMG technology development process, we evaluated the compatibility of the RFMG with a graphite-epoxy composite material used to construct propellant tanks. The key material property that can affect compatibility with the RFMG is the electrical conductivity. Using samples of 8552IM7 graphite-epoxy composite, we characterized the resistivity and reflectivity over a range of frequencies. An RF impedance analyzer was used to characterize the out-of-plane electrical properties (along the sample thickness) in the frequency range 10 to 1800 MHZ. The resistivity value at 500 MHz was 4.8 ohm-cm. Microwave waveguide measurements of samples in the range 1.7 2.6 GHz, performed by inserting the samples into a WR-430 waveguide, showed reflectivity values above 98. Together, these results suggested that a tank constructed from graphite-epoxy composite would produce good quality electromagnetic tank modes, which is needed for the RFMG. This was verified by room-temperature measurements of the electromagnetic modes of a 2.4 m diameter tank constructed by Boeing from similar graphite-epoxy composite material. The quality factor Q of the tank electromagnetic modes, measured via RF reflection measurements from an antenna mounted in the tank, was typically in the range 400 Q 3000. The good quality modes observed in the tank indicate that the RFMG is compatible with graphite-epoxy tanks, and thus the RFMG could be used as a low-gravity propellant quantity gauge in such tanks filled with cryogenic propellants.

  14. Technology.

    Science.gov (United States)

    Online-Offline, 1998

    1998-01-01

    Focuses on technology, on advances in such areas as aeronautics, electronics, physics, the space sciences, as well as computers and the attendant progress in medicine, robotics, and artificial intelligence. Describes educational resources for elementary and middle school students, including Web sites, CD-ROMs and software, videotapes, books,…

  15. Constructional requirements and classification of nucleonic gauges

    International Nuclear Information System (INIS)

    Gomes, J.D.R.L.; Costa, M.L.L.; Gomes, R.S.; Costa, E.L.C.; Caldas, G.H.F.; Thomé, Z.D.

    2017-01-01

    There are several hundred of nucleonic gauges installed in at least 500 industrial facilities in Brazil. In recent years, several standards have been issued by different international committees in order to specify requirements for the design of nucleonic gauges taking into account issues related to radiological protection. The aspects of design and manufacturing of these devices using radioactive sources should be treated as an important feature to an adequate safety approach during the whole operational life, mainly taking into account the extreme conditions of the places where the devices are installed. Thus, the agreement with these standards should be included as part of the equipment specification to the licensing process, however, most nucleonic gauges were installed in the period prior to the issuance of these international standards. In this work was studied the performance of shielding design taking into account international standards concerning the constructional requirements and classification of gauges. In view of the specific operational conditions found at reference facilities, the measurements obtained will be used for validation of a Monte Carlo code based on GEANT4 to allow extrapolations for other operational conditions. The results obtained in this study can enable the establishment of a safety indicator tool to industrial facilities, taking into account different designs, so that this additional parameter can be used to determine and to optimize the frequency of regulatory inspections. (author)

  16. Spontaneous symmetry breakdown in gauge theories

    International Nuclear Information System (INIS)

    Scadron, M.D.

    1982-01-01

    The dynamical theory of spontaneous breakdown correctly predicts the bound states and relates the order parameters of electron-photon superconductivity and quark-gluon chiral symmetry. A similar statement cannot be made for the standard electro-weak gauge symmetry. (author)

  17. Conformal transformation, gauge fields and trace anomaly

    Energy Technology Data Exchange (ETDEWEB)

    Alves, M.S.; Barcelos-Neto, J.

    1988-02-01

    In a recent work, Padmanabhan (1985 Class. Quant. Grav. 2 4105) showed an interesting way of constructing a general conformally invariant scalar theory by introducing a conformal gauge field. We comment on the extrapolation of this idea to the fermionic field and study the trace anomaly for the scalar case by using the path integral formalism.

  18. Geometric quantization of topological gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Barcelos-Neto, J. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Inst. de Fisica; De Souza, S.M. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Inst. de Fisica

    1995-03-01

    We show that Abelian gauge theories in 2 + 1 space-time dimensions with the introduction of a topological Chern-Simons term can be quantized with the use of the symplectic formalism. The consistency of our results are verified by the agreement with the ones from the Dirac case. (orig.)

  19. Spontaneously broken abelian gauge invariant supersymmetric model

    International Nuclear Information System (INIS)

    Mainland, G.B.; Tanaka, K.

    A model is presented that is invariant under an Abelian gauge transformation and a modified supersymmetry transformation. This model is broken spontaneously, and the interplay between symmetry breaking, Goldstone particles, and mass breaking is studied. In the present model, spontaneously breaking the Abelian symmetry of the vacuum restores the invariance of the vacuum under a modified supersymmetry transformation. (U.S.)

  20. Supersymmetry search via gauge boson fusion

    Indian Academy of Sciences (India)

    We propose a novel method for the search of supersymmetry, especially for the electroweak gauginos at the large hadron collider (LHC). Gauge boson fusion technique was shown to be useful for heavy and intermediate mass Higgs bosons. In this article, we have shown that this method can also be applied to find the ...

  1. Gauge invariance and fractional quantized Hall effect

    International Nuclear Information System (INIS)

    Tao, R.; Wu, Y.S.

    1984-01-01

    It is shown that gauge invariance arguments imply the possibility of fractional quantized Hall effect; the Hall conductance is accurately quantized to a rational value. The ground state of a system showing the fractional quantized Hall effect must be degenerate; the non-degenerate ground state can only produce the integral quantized Hall effect. 12 references

  2. National Computational Infrastructure for Lattice Gauge Theory

    Energy Technology Data Exchange (ETDEWEB)

    Brower, Richard C.

    2014-04-15

    SciDAC-2 Project The Secret Life of Quarks: National Computational Infrastructure for Lattice Gauge Theory, from March 15, 2011 through March 14, 2012. The objective of this project is to construct the software needed to study quantum chromodynamics (QCD), the theory of the strong interactions of sub-atomic physics, and other strongly coupled gauge field theories anticipated to be of importance in the energy regime made accessible by the Large Hadron Collider (LHC). It builds upon the successful efforts of the SciDAC-1 project National Computational Infrastructure for Lattice Gauge Theory, in which a QCD Applications Programming Interface (QCD API) was developed that enables lattice gauge theorists to make effective use of a wide variety of massively parallel computers. This project serves the entire USQCD Collaboration, which consists of nearly all the high energy and nuclear physicists in the United States engaged in the numerical study of QCD and related strongly interacting quantum field theories. All software developed in it is publicly available, and can be downloaded from a link on the USQCD Collaboration web site, or directly from the github repositories with entrance linke http://usqcd-software.github.io

  3. Extended monopoles in gauge field theories

    International Nuclear Information System (INIS)

    Horvath, Z.; Palla, L.

    1977-04-01

    The paper gives a review of the 't Hooft monopole and briefly discusses the general topological considerations connected with monopoles. A method is presented for constructing explicit monopole solutions in any gauge theory. Some stability questions and time-dependent problems are also considered

  4. 27 CFR 19.319 - Production gauge.

    Science.gov (United States)

    2010-04-01

    ... volumetrically, in a calibrated tank, converting the wine gallons determined into proof gallons, and determining... deposit in bond on the same plant premises. The gauge record shall indicate “Deposit in storage” or “Deposit in processing.” If spirits are to be transferred in bond, or withdrawn from bond, as authorized by...

  5. Gauge coupling renormalization in Ads5

    Indian Academy of Sciences (India)

    2 action. We consider contributions from fields with arbitrary spins and arbitrary orbifold parities. For supersymmetric case, the calculation can be carried over in the framework of 4D low energy effective supergravity. The 1-loop gauge couplings can be determined by the loop-induced axion couplings and the tree level ...

  6. Local gauge invariant QED with fundamental length

    International Nuclear Information System (INIS)

    Kadyshevsky, V.G.; Mateev, M.D.

    1981-01-01

    A local gauge theory of electromagnetic interactions with the fundamental length l as a new universal scale is worked out. The Lagrangian contains new extra terms in which the coupling constant is proportional to the fundamental length. The theory has an elegant geometrical basis: in momentum representation one faces de Sitter momentum space with curvature radius 1/l [ru

  7. Monte Carlo simulations of lattice gauge theories

    International Nuclear Information System (INIS)

    Forcrand, P. de; Minnesota Univ., Minneapolis, MN

    1989-01-01

    Lattice gauge simulations are presented in layman's terms. The need for large computer resources is justified. The main aspects of implementations on vector and parallel machines are explained. An overview of state of the art simulations and dedicated hardware projects is presented. 8 refs.; 1 figure; 1 table

  8. Н(1) Gauge theory as quantum hydrodynamics

    Indian Academy of Sciences (India)

    has used the eigenfunctional theory to derive an expression for the same quantity that agrees with the expression derived in this article. We apply this method to compute the velocity-velocity correlation function and demonstrate the power of this method in accounting for vortices in a gauge invariant manner. 2. Density ...

  9. Recent advances in lattice gauge theories

    Indian Academy of Sciences (India)

    Abstract. Recent progress in the field of lattice gauge theories is briefly reviewed for a nonspecialist audience. While the emphasis is on the latest and more definitive results that have emerged prior to this symposium, an effort has been made to provide them with minimal technicalities.

  10. Space-time and Local Gauge Symmetries

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 6; Issue 2. Symmetries of Particle Physics: Space-time and Local Gauge Symmetries. Sourendu Gupta. General Article Volume 6 Issue 2 February 2001 pp 29-38. Fulltext. Click here to view fulltext PDF. Permanent link:

  11. Supersymmetry search via gauge boson fusion

    Indian Academy of Sciences (India)

    Abstract. We propose a novel method for the search of supersymmetry, especially for the elec- troweak gauginos at the large hadron collider (LHC). Gauge boson fusion technique was shown to be useful for heavy and intermediate mass Higgs bosons. In this article, we have shown that this method can also be applied to ...

  12. A HIGH VACUUM GAUGE CALIBRATION SYSTEM

    Science.gov (United States)

    An ultra- high vacuum type metal and glass system was constructed for the purpose of calibrating vacuum gauges in the pressure region from 760 to 10...to the -7th power torr. The high vacuum portion of the system is bakeable at temperatures up to 450 C. A mercury manometer serves as a pressure

  13. An effective theory of massive gauge bosons

    International Nuclear Information System (INIS)

    Doria, R.M.; Helayel Neto, J.A.

    1986-01-01

    The coupling of a group-valued massive scalar field to a gauge field through a symmetric rank-2 field strenght is studied. By considering energies very small compared with the mass of the scalar and invoking the decoupling theorem, one is left with a low-energy effective theory describing a dynamics of massive vector fields. (Author) [pt

  14. Supersymmetry search via gauge boson fusion

    Indian Academy of Sciences (India)

    canonical search strategies for these particles fail. Keywords. Gauge boson fusion; supersymmetry. PACS Nos 11.30.Pb; 12.60.Jv; 14.80.Ly; 13.85.Rm. 1. Introduction. Vector boson fusion (VBF) at hadronic colliders has been suggested as a useful channel for studying the signal of the Higgs boson. Characteristic features of ...

  15. Mathematical and physical aspects of gauge theories

    International Nuclear Information System (INIS)

    Chatelet, G.; Paris-13 Univ., 93 - Saint-Denis

    1981-01-01

    We present here a survey of gauge theories, trying to relate the main mathematical and physical concepts. Part I is devoted to exhibiting parallel transport and connection as the adequate concepts for the constitution of the parametrized internal space of a particle. A covariant derivative provides the differential calculus, which is needed when one leaves the point-like description in microphysics. Part II deals with the so-called pure gauge theory and sketches the construction of the self-dual solutions of Yang-Mills equations. We briefly explain Guersey's method to get SU 2 self-dual potentials as quarternionic analytic maps from S 4 (first quarternionic projective space) into HPsub(n) (n-dimensional quarternionic projective space). Part III is devoted to the Goldstone's theorem and Higgs' mechanism used to provide a mass to gauge mesons. We describe a Salam-Weinberg model to illustrate these techniques. Part IV deals with the perturbative aspect. The Faddeev-Popov method, formerly conceived as a technique to get correct Feynmann rules, actually leads to a systematic study of the affine space of connections factored out by gauge transformations. (orig.)

  16. Gauge Physics of Finance: simple introduction

    OpenAIRE

    Ilinski, Kirill N

    1998-01-01

    In this paper we state the fundamental principles of the gauge approach to financial economics and demonstrate the ways of its application. In particular, modelling of realistic price processes is considered for an example of S&P500 market index. Derivative pricing and portfolio theory are also briefly discussed.

  17. Flavor gauge models below the Fermi scale

    Science.gov (United States)

    Babu, K. S.; Friedland, A.; Machado, P. A. N.; Mocioiu, I.

    2017-12-01

    The mass and weak interaction eigenstates for the quarks of the third generation are very well aligned, an empirical fact for which the Standard Model offers no explanation. We explore the possibility that this alignment is due to an additional gauge symmetry in the third generation. Specifically, we construct and analyze an explicit, renormalizable model with a gauge boson, X, corresponding to the B - L symmetry of the third family. Having a relatively light (in the MeV to multi-GeV range), flavor-nonuniversal gauge boson results in a variety of constraints from different sources. By systematically analyzing 20 different constraints, we identify the most sensitive probes: kaon, B +, D + and Upsilon decays, D-{\\overline{D}}^0 mixing, atomic parity violation, and neutrino scattering and oscillations. For the new gauge coupling g X in the range (10-2-10-4) the model is shown to be consistent with the data. Possible ways of testing the model in b physics, top and Z decays, direct collider production and neutrino oscillation experiments, where one can observe nonstandard matter effects, are outlined. The choice of leptons to carry the new force is ambiguous, resulting in additional phenomenological implications, such as non-universality in semileptonic bottom decays. The proposed framework provides interesting connections between neutrino oscillations, flavor and collider physics.

  18. Gauge theories of the weak interactions

    International Nuclear Information System (INIS)

    Quinn, H.

    1978-08-01

    Two lectures are presented on the Weinberg--Salam--Glashow--Iliopoulos--Maiani gauge theory for weak interactions. An attempt is made to give some impressions of the generality of this model, how it was developed, variations found in the literature, and the status of the standard model. 21 references

  19. Gauge coupling renormalization in Ads5

    Indian Academy of Sciences (India)

    By simple dimensional analysis, we note that 1 g25a diverges depending linearly on cut-off A and 1 g20a and 1 g2πa diverges logarithmically. One-loop correction to the low energy gauge coupling also contains conventional logarithmic running in 4D effective theory and calculable threshold corrections from matching 5D ...

  20. Exact renormalization group for gauge theories

    International Nuclear Information System (INIS)

    Balaban, T.; Imbrie, J.; Jaffe, A.

    1984-01-01

    Renormalization group ideas have been extremely important to progress in our understanding of gauge field theory. Particularly the idea of asymptotic freedom leads us to hope that nonabelian gauge theories exist in four dimensions and yet are capable of producing the physics we observe-quarks confined in meson and baryon states. For a thorough understanding of the ultraviolet behavior of gauge theories, we need to go beyond the approximation of the theory at some momentum scale by theories with one or a small number of coupling constants. In other words, we need a method of performing exact renormalization group transformations, keeping control of higher order effects, nonlocal effects, and large field effects that are usually ignored. Rigorous renormalization group methods have been described or proposed in the lectures of Gawedzki, Kupiainen, Mack, and Mitter. Earlier work of Glimm and Jaffe and Gallavotti et al. on the /phi/ model in three dimensions were quite important to later developments in this area. We present here a block spin procedure which works for gauge theories, at least in the superrenormalizable case. It should be enlightening for the reader to compare the various methods described in these proceedings-especially from the point of view of how each method is suited to the physics of the problem it is used to study

  1. New technique for the fabrication of miniature thin film heat flux gauges

    Science.gov (United States)

    Collins, Matthew; Chana, Kam; Povey, Thomas

    2015-02-01

    This paper details the improvements made to the design and fabrication of thin-film heat flux gauges at Oxford. These improvements have been driven by the desire to improve measurement accuracy and resolution in short duration wind-tunnel experiments. A thin-film heat flux gauge (TFHFG) measures heat flux by recording the temperature history of thin film resistive temperature sensors sputtered onto an insulating substrate. The heat flux can then be calculated using Fourier’s law of heat conduction. A new fabrication process utilising technology from the manufacture of flexible printed circuit boards is outlined, which enables the production of significantly smaller and more robust gauges than those previously used.

  2. Discharge gauging without a hydrologist (Invited)

    Science.gov (United States)

    Weiler, M.; Grether, M.; Blattmann, E.

    2009-12-01

    Discharge data are still the core variable for any hydrological research. Sensors to continuously observe water level in streams have become cheap and their set-up without any hydraulic gauging structure is fast and relative easy. Thus it should be possible in the future to gauge and observe a large variety of watersheds, to learn from the collected datasets, and consequently to overcome the problem of ungauged watersheds. However, the major challenge remaining is to develop a reliable stage-discharge relationship that does not require manual discharge measurements over many years at high costs to the hydrological services. This challenges in particular concerns remote areas and turbulent and flashy streams, where hydraulic gauging structures cannot be constructed due to ecological or financial constrains. The stage-discharge relationship in these streams is often poorly defined since the cross-section or hydraulic properties are changing continuously. Especially at high flows a large error has to be assumed since discharge could not be continuously observed. We developed and tested a new instrument for continuous discharge monitoring in turbulent streams. This tool is designed to reliably observe discharge in these streams and to obtain hundreds of discharge measurements to construct a stage-discharge relationship within a couple of weeks. The Automatic Dilution Gauging System (ADiGS) is a self-controlled instrument for dilution gauging using florescent dyes as a tracer. Because of its technical setup with low power consumption, automatic tracer injection, effective data storage and the possibility to transfer or receive data by wireless communication, ADiGS can be used as a stand-alone tool. It can therefore be easily deployed to establish time- and cost-effectively stage-discharge relations in low accessible regions or under financial constraints.

  3. Chirality conservation in the lattice gauge theory

    International Nuclear Information System (INIS)

    Peskin, M.E.

    1978-01-01

    The derivation of conservation laws corresponding to chiral invariance in quantum field theories of interacting quarks and gluons are studied. In particular there is interest in observing how these conservation laws are constrained by the requirement that the field theory be locally gauge invariant. To examine this question, a manifestly gauge-invariant definition of local operators in a quantum field theory is introduced, a definition which relies in an essential way on the use of the formulation of gauge fields on a lattice due to Wilson and Polyakov to regulate ultraviolet divergences. The conceptual basis of the formalism is set out and applied to a long-standing puzzle in the phenomenology of quark-gluon theories: the fact that elementary particle interactions reflect the conservation of isospin-carrying chiral currents but not of the isospin-singlet chiral current. It is well known that the equation for the isospin-singlet current contains an extra term, the operator F/sub mu neu/F/sup mu neu/, not present in the other chirality conservation laws; however, this term conventionally has the form of a total divergence and so still allows the definition of a conserved chiral current. It is found that, when the effects of maintaining gauge invariance are properly taken into account, the structure of this operator is altered by renormalization effects, so that it provides an explicit breaking of the unwanted chiral invariance. The relation between this argument, based on renormaliztion, is traced to a set of more heuristic arguments based on gauge field topology given by 't Hooft; it is shown that the discussion provides a validation, through short-distance analysis, of the picture 'Hooft has proposed. The formal derivation of conservation laws for chiral currents are set out in detail

  4. The gauge-independent QCD effective charge

    International Nuclear Information System (INIS)

    Watson, N.J.

    1999-01-01

    It is shown how the QCD concept of a gauge-, scale-and scheme-independent one-loop effective charge can be extended directly at the diagrammatic level to QCD, thus justifying explicitly the 'naive non-abelialization' prescription used in renormalon calculus. It is first argued that, for one-shell external fields and at the strictly one-loop level, the required gluon self-energy-like function is precisely that obtained from S-matrix elements via the pinch technique. The generalization of the pinch technique to explicitly off-shell processes is then introduced. It is shown how, as a result of a fundamental cancellation among conventional perturbation theory diagrams encoded in the QCD Ward identities, the pinch technique one-loop gluon self-energy iΠ μν ab (q) remains gauge-independent and universal regardless of the fact that the 'external' fields in the given process are off-shell. This demonstration involves a simple technique enabling the isolation in a arbitrary gauge, of iΠ μν ab (q) from subclasses of up to several hundreds diagrams at once. Furthermore, it is shown how this one-loop cancellation mechanism iterates for the subclasses of n-loop diagrams containing implicitly the Dyson chains of n-loop self energies iΠ μν ab (q). The gauge cancellation required for the Dyson summation of iΠ μν ab (q) is thus demonstrated explicitly in the class of ghost-free gauges for all orders n. (authors)

  5. The gauge-independent QCD effective charge

    International Nuclear Information System (INIS)

    Watson, N.J.

    1997-01-01

    It is shown how the QED concept of a gauge-, scale- and scheme-independent one-loop effective charge can be extended directly at the diagrammatic level to QCD, thus justifying explicitly the ''naive non-abelianization'' prescription used in renormalon calculus. It is first argued that, for on-shell external fields and at the strictly one-loop level, the required gluon self-energy-like function is precisely that obtained from S-matrix elements via the pinch technique. The generalization of the pinch technique to explicitly off-shell processes is then introduced. It is shown how, as a result of a fundamental cancellation among conventional perturbation theory diagrams, encoded in the QCD Ward identities, the pinch technique one-loop gluon self-energy iΠ μν ab (q) remains gauge-independent and universal regardless of the fact that the ''external'' fields in the given process are off-shell. This demonstration involves a simple technique enabling the isolation, in an arbitrary gauge, of iΠ μν ab (q) from subclasses of up to several hundred diagrams at once. Furthermore, it is shown how this one-loop cancellation mechanism iterates for the subclasses of n-loop diagrams containing implicitly the Dyson chains of n one-loop self-energies iΠ μν ab (q). The gauge cancellation required for the Dyson summation of iΠ μν ab (q) is thus demonstrated explicitly in a general class of ghost-free gauges for all orders n. (orig.)

  6. Relativity and equivalence principles in the gauge theory of gravitation

    International Nuclear Information System (INIS)

    Ivanenko, D.; Sardanashvili, G.

    1981-01-01

    Roles of relativity (RP) and equivalence principles (EP) in the gauge theory of gravity are shown. RP in the gravitational theory in formalism of laminations can be formulated as requirement of covariance of equations relative to the GL + (4, R)(X) gauge group. In such case RP turns out to be identical to the gauge principle in the gauge theory of a group of outer symmetries, and the gravitational theory can be directly constructed as the gauge theory. In general relativity theory the equivalence theory adds RP and is intended for description of transition to a special relativity theory in some system of reference. The approach described takes into account that in the gauge theory, besides gauge fields under conditions of spontaneous symmetry breaking, the Goldstone and Higgs fields can also arise, to which the gravitational metric field is related, what is the sequence of taking account of RP in the gauge theory of gravitation [ru

  7. Gauge theories under incorporation of a generalized uncertainty principle

    International Nuclear Information System (INIS)

    Kober, Martin

    2010-01-01

    There is considered an extension of gauge theories according to the assumption of a generalized uncertainty principle which implies a minimal length scale. A modification of the usual uncertainty principle implies an extended shape of matter field equations like the Dirac equation. If there is postulated invariance of such a generalized field equation under local gauge transformations, the usual covariant derivative containing the gauge potential has to be replaced by a generalized covariant derivative. This leads to a generalized interaction between the matter field and the gauge field as well as to an additional self-interaction of the gauge field. Since the existence of a minimal length scale seems to be a necessary assumption of any consistent quantum theory of gravity, the gauge principle is a constitutive ingredient of the standard model, and even gravity can be described as gauge theory of local translations or Lorentz transformations, the presented extension of gauge theories appears as a very important consideration.

  8. CogGauge (A Cognitive Assessment Tool), Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The Cognitive Gauge (CogGauge) tool aims to develop a portable gaming application that assesses cognitive state of astronaut crew members with the goal of...

  9. A high temperature interparticle potential for an alternative gauge model

    International Nuclear Information System (INIS)

    Doria, R.M.

    1984-01-01

    A thermal Wilson loop for a model with two gauge fields associated with the same gauge group is discussed. Deconfinement appears at high temperature. It is not possible however specify the colour of the deconfined matter. (Author) [pt

  10. Gaugings of N = 4 three dimensional gauged supergravity with exceptional coset manifolds

    Science.gov (United States)

    Karndumri, Parinya

    2012-08-01

    Some admissible gauge groups of N = 4 Chern-Simons gauged supergravity in three dimensions with exceptional scalar manifolds G 2(2) /SO(4), F 4(4) /USp(6) × SU(2), E 6(2) /SU(6) × SU(2), E 7(-5) /SO(12) × SU(2) and E 8(-24) /E 7 × SU(2) are identified. In particular, a complete list of all possible gauge groups is given for the theory with G 2(2) /SO(4) coset space. We also study scalar potentials for all of these gauge groups and find some critical points. In the case of F 4(4) /USp(6) × SU(2) target space, we give some semisimple gauge groups which are maximal subgroups of F 4(4). Most importantly, we construct the SO(4) ⋉ T 6 gauged supergravity which is equivalent to N = 4 SO(4) Yang-Mills gauged supergravity. The latter is proposed to be obtained from an S 3 reduction of (1 , 0) six dimensional supergravity coupled to two vector and two tensor multiplets. The scalar potential of this theory on the scalar fields which are invariant under SO(4) is explicitly computed. Depending on the value of the coupling constants, the theory admits both dS and AdS vacua when all of the 28 scalars vanish. The maximal N = 4 supersymmetric AdS 3 should correspond to the AdS 3 × S 3 solution of the (1 , 0) six dimensional theory. Finally, some gauge groups of the theories with E 6(2) /SU(6) × SU(2), E 7(-5) /SO(12) × SU(2) and E 8(-24) /E 7 × SU(2) scalar manifolds are identified.

  11. The holomorphicity of the gauge coupling constant in supersymmetric gauge theories

    International Nuclear Information System (INIS)

    Li, H.

    1993-01-01

    Holomorphicity is the analytical dependence of the gauge coupling function, f = 1/g 2 + Θ/8π 2 , on the chiral fields in supergravity and supersymmetric gauge theories. The holomorphic property of 1/g 2 in supersymmetric gauge theories is studied by calculating its dependence on the mass matrix. The general representations of the mass matrix allowed by the constraints of gauge invariance is considered, and calculate the one- and two-loop corrections to 1/g 2 for both super QED and super Yang-Mills theories. For the massive mass matrix it is shown that one- and two-loop corrections to the gauge coupling constant are holomorphic. The reason for two-loop holomorphicity is that the second order logarithmic terms cancel out. For the mass matrix with at least one zero mode, it is recognized that there are two distinct cases which we call pseudo massive and intrinsically massless. For the case of pseudo mass matrix, the reducible representation of the gauge group is (i) complex with equal numbers of irreducible representations and their conjugates, (ii) real, or (iii) pseudo-real. Even though there are massless modes, it is found that the dependence of the gauge coupling constant on the mass matrix is holomorphic. This holomorphicity follows because the mass matrix can be perturbed to regularize the infrared divergence. For the case of intrinsically massless mass matrix, a reducible complex representation with unequal numbers of irreducible representations and their conjugates. The author shows that loop corrections to the gauge coupling constant are non-holomorphic. The reason is an infrared momentum cutoff is used which spins holomorphicity. The results show that, for the pseudo massive case, even though there is an infrared divergence, the one- and two-loop corrections are still holomorphic. Hence, it is concluded that non-holomorphicity is caused by the unbalanced numbers of families and antifamilies in the complex representation

  12. Study of intraocular pressure after 23-gauge and 25-gauge pars plana vitrectomy randomized to fluid versus air fill.

    Science.gov (United States)

    Ho, Lawrence Y; Garretson, Bruce R; Ranchod, Tushar M; Balasubramaniam, Mamtha; Ruby, Alan J; Capone, Antonio; Drenser, Kimberly A; Williams, George A; Hassan, Tarek S

    2011-06-01

    To determine if a difference in intraocular pressure (IOP) exists after small-gauge pars plana vitrectomy randomized to fluid versus 80% sterile air fill. Ninety-two eyes undergoing 23-gauge and 25-gauge transconjunctival pars plana vitrectomy were randomized to fluid versus air fill, and IOP was measured at 5 different time points. There is no difference in the mean IOP for eyes undergoing small-gauge pars plana vitrectomy randomized to fluid versus air fill after vitrectomy. Using 23-gauge instrumentation, the mean immediate and 2-hour postoperative IOPs were statistically lower than the mean preoperative IOP. The mean Postoperative Day 1 and Week 1 IOPs were statistically higher than the mean immediate postoperative IOP. Using 25-gauge instrumentation, the mean IOP was not statistically different at any time points in the 2 groups. When comparing 23-gauge with 25-gauge instrumentation, the immediate postoperative IOP was statistically lower and the rate of suture closure for sclerotomies was higher for 23-gauge vitrectomy. When performing 23-gauge or 25-gauge pars plana vitrectomy, there was no difference in mean IOP for fluid- versus air-filled eyes. However, the mean IOP in the immediate postoperative period was statistically lower, and there was a higher rate of suture closure for 23-gauge compared with 25-gauge instrumentation.

  13. Gauge dependences of the covariant effective action in QED

    Science.gov (United States)

    Nachbagauer, Herbert; Kraemmer, Ulrike; Rebhan, Anton

    1989-07-01

    A recent computation of the (nonlocal) covariant effective action of QED in weak constant external electromagnetic fields is generalized to general Lorentz gauges and its gauge dependence is displayed, and it is then removed by the prescription for a gauge and parametrization independent effective action according to Vilkovisky. The geometry, which in this framework is ascribed to the field configuration space of QED, is made explicit, and it is shown that Vilkovisky's effective action coincides with the conventional Landau gauge case.

  14. A gauge field theory of fermionic continuous-spin particles

    Energy Technology Data Exchange (ETDEWEB)

    Bekaert, X., E-mail: xavier.bekaert@lmpt.univ-tours.fr [Laboratoire de Mathématiques et Physique Théorique, Unité Mixte de Recherche 7350 du CNRS, Fédération de Recherche 2964 Denis Poisson, Université François Rabelais, Parc de Grandmont, 37200 Tours (France); B.W. Lee Center for Fields, Gravity and Strings, Institute for Basic Science, Daejeon (Korea, Republic of); Najafizadeh, M., E-mail: mnajafizadeh@gmail.com [Laboratoire de Mathématiques et Physique Théorique, Unité Mixte de Recherche 7350 du CNRS, Fédération de Recherche 2964 Denis Poisson, Université François Rabelais, Parc de Grandmont, 37200 Tours (France); Department of Physics, Faculty of Sciences, University of Kurdistan, 66177-15177 Sanandaj (Iran, Islamic Republic of); Setare, M.R., E-mail: rezakord@ipm.ir [Department of Physics, Faculty of Sciences, University of Kurdistan, 66177-15177 Sanandaj (Iran, Islamic Republic of)

    2016-09-10

    In this letter, we suggest a local covariant action for a gauge field theory of fermionic Continuous-Spin Particles (CSPs). The action is invariant under gauge transformations without any constraint on both the gauge field and the gauge transformation parameter. The Fang–Fronsdal equations for a tower of massless fields with all half-integer spins arise as a particular limit of the equation of motion of fermionic CSPs.

  15. A gauge field theory of fermionic continuous-spin particles

    International Nuclear Information System (INIS)

    Bekaert, X.; Najafizadeh, M.; Setare, M.R.

    2016-01-01

    In this letter, we suggest a local covariant action for a gauge field theory of fermionic Continuous-Spin Particles (CSPs). The action is invariant under gauge transformations without any constraint on both the gauge field and the gauge transformation parameter. The Fang–Fronsdal equations for a tower of massless fields with all half-integer spins arise as a particular limit of the equation of motion of fermionic CSPs.

  16. New Methods in Supersymmetric Theories and Emergent Gauge Symmetry

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    It is remarkable that light or even massless spin 1 particles can be composite. Consequently, gauge invariance is not fundamental but emergent. This idea can be realized in detail in supersymmetric gauge theories. We will describe the recent development of non-perturbative methods that allow to test this idea. One finds that the emergence of gauge symmetry is linked to some results in contemporary mathematics. We speculate on the possible applications of the idea of emergent gauge symmetry to realistic models.

  17. Low-temperature strain gauges based on silicon whiskers

    Directory of Open Access Journals (Sweden)

    Druzhinin A. A.

    2008-08-01

    Full Text Available To create low-temperature strain gauges based on p-type silicon whiskers tensoresistive characteristics of these crystals in 4,2—300 K temperature range were studied. On the basis of p-type Si whiskers with different resistivity the strain gauges for different materials operating at cryogenic temperatures with extremely high gauge factor at 4,2 K were developed, as well as strain gauges operating at liquid helium temperatures in high magnetic fields.

  18. Gauges for the Ginzburg-Landau equations of superconductivity

    International Nuclear Information System (INIS)

    Fleckinger-Pelle, J.; Kaper, H.G.

    1995-01-01

    This note is concerned with gauge choices for the time-dependent Ginzburg-Landau equations of superconductivity. The requiations model the state of a superconducting sample in a magnetic field near the critical tempeature. Any two solutions related through a ''gauge transformation'' describe the same state and are physically indistinquishable. This ''gauge invariance'' can be exploited for analtyical and numerical purposes. A new gauge is proposed, which reduces the equations to a particularly attractive form

  19. Octonionic gauge theory from spontaneously broken SO(8)

    International Nuclear Information System (INIS)

    Lassig, C.C.; Joshi, G.C.

    1995-01-01

    An attempt is made to construct a gauge theory based on a bimodular representation of the octonion algebra, the non associativity of which is manifested as a non-closure of the bimodule algebra. It is found that this fact leads to gauge-noninvariance of the theory. However, the bimodule algebra can be embedded in SO(8), the gauge theory of which can be broken down to give a massless SO(7) theory together with a massive octonionic gauge theory. 7 refs

  20. 46 CFR 153.979 - Gauging with a sounding tube.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Gauging with a sounding tube. 153.979 Section 153.979... Procedures § 153.979 Gauging with a sounding tube. (a) No person may remove the cover of a sounding tube... cargo transfer may not authorize removal of the cover from a sounding tube gauge unless all tank...